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+NextprotID	ProteinName	SeqLength	MW	IsoPoint	TMDomains	SubcellLocations	Diseases	Function	PostTranslationalModifications	ProteinFamily	Pathway	ProteinExistence	Chr
+NX_A0A024RBG1	Diphosphoinositol polyphosphate phosphohydrolase NUDT4B	181	20434	5.99	0	Cytoplasm	NA	Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.	NA	Belongs to the Nudix hydrolase family. DIPP subfamily.	NA	PE1	1
+NX_A0A075B6H9	Immunoglobulin lambda variable 4-69	119	12773	6.01	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6I0	Immunoglobulin lambda variable 8-61	122	12814	4.33	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6I1	Immunoglobulin lambda variable 4-60	120	12987	5.8	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6I4	Immunoglobulin lambda variable 10-54	117	12395	7.85	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6I9	Immunoglobulin lambda variable 7-46	117	12468	6.69	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6J1	Immunoglobulin lambda variable 5-37	123	13277	4.75	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6J6	Immunoglobulin lambda variable 3-22	115	12549	3.95	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6J9	Immunoglobulin lambda variable 2-18	118	12412	4.66	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6K0	Immunoglobulin lambda variable 3-16	115	12466	4.58	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6K2	Immunoglobulin lambda variable 3-12	115	12387	5.34	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6K4	Immunoglobulin lambda variable 3-10	115	12441	4.72	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6K5	Immunoglobulin lambda variable 3-9	115	12332	6.81	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6K6	Immunoglobulin lambda variable 4-3	122	13330	5.39	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A075B6N1	T cell receptor beta variable 19	114	12769	6.53	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	7
+NX_A0A075B6N2	T cell receptor beta variable 20-1	111	12175	8.52	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	7
+NX_A0A075B6N3	T cell receptor beta variable 24-1	115	12929	7.68	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A075B6N4	T cell receptor beta variable 25-1	114	12983	5.91	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A075B6P5	Immunoglobulin kappa variable 2-28	120	12957	5.61	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_A0A075B6Q5	Immunoglobulin heavy variable 3-64	118	12891	7.69	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A075B6R0	T cell receptor gamma variable 2	118	13310	7.75	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	7
+NX_A0A075B6R2	Immunoglobulin heavy variable 4-4	117	12848	9.64	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A075B6S0	T cell receptor gamma joining 1	16	1791	9.53	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	7
+NX_A0A075B6S2	Immunoglobulin kappa variable 2D-29	120	13143	6.53	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A075B6S4	Immunoglobulin kappa variable 1D-17	117	12835	9.22	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A075B6S5	Immunoglobulin kappa variable 1-27	117	12712	8.5	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A075B6S6	Immunoglobulin kappa variable 2D-30	120	13215	7.79	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_A0A075B6T6	T cell receptor alpha variable 12-2	113	12838	6.17	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A075B6T7	T cell receptor alpha variable 6	132	15362	9.2	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A075B6T8	T cell receptor alpha variable 9-1	112	12354	4.83	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A075B6U4	T cell receptor alpha variable 7	112	12598	8.39	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A075B6V5	T cell receptor alpha variable 36/delta variable 7	113	12697	6.57	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A075B6W5	T cell receptor alpha variable 23/delta variable 6	121	13545	8.45	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A075B6X5	T cell receptor alpha variable 18	111	12414	5.26	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A075B6Y3	T cell receptor alpha joining 3	20	2097	11	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	14
+NX_A0A075B6Y9	T cell receptor alpha joining 42	20	2051	10	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	14
+NX_A0A075B706	T cell receptor delta joining 1	16	1761	8.26	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	14
+NX_A0A075B759	Peptidyl-prolyl cis-trans isomerase A-like 4E	164	18197	9.43	0	Cytoplasm	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).	NA	Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.	NA	PE2	1
+NX_A0A075B767	Peptidyl-prolyl cis-trans isomerase A-like 4H	164	18208	9.19	0	Cytoplasm	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.	NA	Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.	NA	PE1	1
+NX_A0A087WSX0	Immunoglobulin lambda variable 5-45	123	13162	6.69	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A087WSY4	Immunoglobulin heavy variable 4-30-2	118	13025	9.7	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	3
+NX_A0A087WSY6	Immunoglobulin kappa variable 3D-15	115	12534	5.14	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A087WSZ0	Immunoglobulin kappa variable 1D-8	117	12837	7.62	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A087WSZ9	T cell receptor alpha variable 30	112	12582	8.58	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A087WT01	T cell receptor alpha variable 27	109	12043	5.7	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A087WT02	T cell receptor alpha variable 9-2	112	12289	5.26	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A087WT03	T cell receptor alpha variable 26-1	109	12306	7.76	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A087WTH1	Transmembrane protein 265	108	11832	7.61	2	Membrane	NA	NA	NA	Belongs to the CD225/Dispanin family.	NA	PE2	16
+NX_A0A087WTH5	Potassium voltage-gated channel subfamily E member 1B	132	15028	8.73	1	Membrane	NA	NA	NA	Belongs to the potassium channel KCNE family.	NA	PE2	21
+NX_A0A087WUL8	Neuroblastoma breakpoint family member 19	3843	440408	4.53	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE5	1
+NX_A0A087WV53	SPEG neighbor protein	238	26075	5.45	0	NA	NA	NA	NA	NA	NA	PE4	2
+NX_A0A087WV62	T cell receptor beta variable 16	115	12845	6.7	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A087WVF3	TBC1 domain family member 3D	549	62187	9.2	0	Cell membrane	NA	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).	Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.;Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.	NA	NA	PE2	17
+NX_A0A087WW87	Immunoglobulin kappa variable 2-40	121	13310	4.43	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A087WWA1	PIK3R3 upstream open reading frame protein	95	10952	12.38	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_A0A087WX78	Putative elongin-A3 member C	387	41674	8.87	0	Nucleus	NA	SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).	NA	NA	NA	PE5	18
+NX_A0A087WXM9	Meiosis-specific kinetochore protein	373	40829	8.65	0	Centromere;Kinetochore	NA	Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.	NA	NA	NA	PE1	5
+NX_A0A087WXS9	TBC1 domain family member 3I	549	62205	9.2	0	Cell membrane	NA	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).	Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.;Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.	NA	NA	PE2	17
+NX_A0A087X0M5	T cell receptor beta variable 18	115	13028	9.14	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A087X179	TBC1 domain family member 3E	549	62131	9.18	0	Cell membrane	NA	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).	Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.;Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.	NA	NA	PE2	17
+NX_A0A087X1C5	Putative cytochrome P450 2D7	515	57489	8.7	2	Membrane;Cytoplasm;Mitochondrion	NA	May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine (PubMed:15051713). However, another study could not confirm it (PubMed:18838503).	NA	Belongs to the cytochrome P450 family.	NA	PE5	22
+NX_A0A087X1G2	TBC1 domain family member 3K	549	62171	9.23	0	Cell membrane	NA	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).	Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.;Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.	NA	NA	PE2	17
+NX_A0A096LNP1	Beta-defensin 131B	70	8156	8.26	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	NA	PE2	11
+NX_A0A096LP01	Small integral membrane protein 26	95	10908	6.24	1	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	20
+NX_A0A096LP49	Coiled-coil domain-containing protein 187	1063	114856	9.76	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_A0A096LP55	Cytochrome b-c1 complex subunit 6-like, mitochondrial	91	10752	4.39	0	Mitochondrion inner membrane	NA	May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.	NA	Belongs to the UQCRH/QCR6 family.	NA	PE2	1
+NX_A0A096LPI5	Protein GVQW2	108	11989	8.8	0	NA	NA	NA	NA	NA	NA	PE2	6
+NX_A0A0A0MRZ7	Immunoglobulin kappa variable 2D-26	120	13297	4.9	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A0A0MRZ8	Immunoglobulin kappa variable 3D-11	115	12625	5.15	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE3	2
+NX_A0A0A0MRZ9	Immunoglobulin lambda variable 5-52	124	13446	7.76	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A0A0MS14	Immunoglobulin heavy variable 1-45	117	13508	9.2	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0A0MS15	Immunoglobulin heavy variable 3-49	119	13056	8.84	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0A0MT36	Immunoglobulin kappa variable 6D-21	114	12340	6.7	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE3	2
+NX_A0A0A0MT70	T cell receptor beta joining 2-6	17	1663	9.47	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0A0MT76	Immunoglobulin lambda joining 1	42	4776	9.53	0	Secreted;Cell membrane	NA	J region of the variable domain of immunoglobulin lambda light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE4	22
+NX_A0A0A0MT78	T cell receptor beta joining 2-7	15	1719	5.72	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0A0MT87	T cell receptor beta joining 2-4	16	1738	9.99	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0A0MT89	Immunoglobulin kappa joining 1	12	1394	8.59	0	Secreted;Cell membrane	NA	J region of the variable domain of immunoglobulin kappa light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE4	2
+NX_A0A0A0MT94	T cell receptor beta joining 2-2	16	1740	4.53	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0A0MTA4	T cell receptor beta joining 2-5	15	1722	6	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0A0MTA7	T cell receptor beta joining 2-1	16	1829	5.72	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0A6YYC5	T cell receptor alpha variable 14/delta variable 4	116	12931	5.34	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A0A6YYD4	T cell receptor beta variable 13	124	13967	5.84	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0A6YYG2	T cell receptor beta variable 6-6	114	12632	7.63	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0A6YYG3	T cell receptor beta variable 6-8	113	12321	7.66	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0A6YYJ7	T cell receptor alpha variable 8-3	113	12676	6.81	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0A6YYK1	T cell receptor alpha variable 8-1	113	12788	7.81	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0A6YYK6	T cell receptor alpha variable 16	109	12578	9.51	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0A6YYK7	T cell receptor alpha variable 19	116	13195	4.75	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	14
+NX_A0A0A6YYL3	POTE ankyrin domain family member B	544	61708	5.75	0	NA	NA	NA	NA	Belongs to the POTE family.	NA	PE1	15
+NX_A0A0B4J1U3	Immunoglobulin lambda variable 1-36	117	12478	4.56	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A0B4J1U4	T cell receptor gamma variable 5	118	13601	8.95	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	7
+NX_A0A0B4J1U6	T cell receptor beta variable 9	114	12608	5.82	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0B4J1U7	Immunoglobulin heavy variable 6-1	121	13481	9.3	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0B4J1V0	Immunoglobulin heavy variable 3-15	119	12926	8.84	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0B4J1V1	Immunoglobulin heavy variable 3-21	117	12840	8.49	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0B4J1V2	Immunoglobulin heavy variable 2-26	119	13182	8.49	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0B4J1V6	Immunoglobulin heavy variable 3-73	119	12858	9.3	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0B4J1X5	Immunoglobulin heavy variable 3-74	117	12840	8.91	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0B4J1X8	Immunoglobulin heavy variable 3-43	118	13077	5.28	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0B4J1Y8	Immunoglobulin lambda variable 9-49	123	13024	6.7	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A0B4J1Y9	Immunoglobulin heavy variable 3-72	119	13203	7.69	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0B4J1Z2	Immunoglobulin kappa variable 1D-43	117	12989	9.1	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A0B4J200	T cell receptor beta joining 2-3	16	1756	5.55	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0B4J234	T cell receptor alpha variable 2	112	12502	6.71	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J235	T cell receptor alpha variable 13-2	113	12716	6.71	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J237	T cell receptor alpha variable 8-2	113	12429	6.89	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J238	T cell receptor alpha variable 1-2	106	11863	5.19	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J240	T cell receptor alpha variable 10	114	12852	9.07	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J241	T cell receptor alpha variable 13-1	112	12580	5.5	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A0B4J244	T cell receptor alpha variable 3	114	12614	7.74	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J245	T cell receptor alpha variable 12-1	112	12865	7.68	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J248	T cell receptor alpha variable 1-1	108	11926	4.49	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J249	T cell receptor alpha variable 5	113	12968	4.78	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J262	T cell receptor alpha variable 8-6	113	12690	5.17	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J263	T cell receptor alpha variable 39	110	12540	7.76	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A0B4J264	T cell receptor alpha variable 38-1	116	13297	6.2	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J265	T cell receptor alpha variable 26-2	109	12172	6.17	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J266	T cell receptor alpha variable 41	112	12352	9.22	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J268	T cell receptor alpha variable 4	109	12215	7.76	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A0B4J271	T cell receptor alpha variable 12-3	114	13173	7.71	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A0B4J272	T cell receptor alpha variable 24	114	12919	5.51	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A0B4J273	T cell receptor alpha variable 34	112	12465	6.28	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J274	T cell receptor alpha variable 20	112	12682	5.02	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A0B4J275	T cell receptor alpha variable 17	112	12500	7.81	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J276	T cell receptor alpha variable 25	109	12388	9	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J277	T cell receptor alpha variable 22	110	12145	6.54	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A0B4J279	T cell receptor alpha variable 21	112	12289	5.21	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	14
+NX_A0A0B4J280	T cell receptor alpha variable 40	105	11556	6.1	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0A0B4J2A2	Peptidyl-prolyl cis-trans isomerase A-like 4C	164	18156	9.32	0	Cytoplasm	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).	NA	Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.	NA	PE2	1
+NX_A0A0B4J2D5	Glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial	268	28142	8.5	0	Mitochondrion	NA	NA	NA	Belongs to the GATD3 family.	NA	PE1	21
+NX_A0A0B4J2D9	Immunoglobulin kappa variable 1D-13	117	12569	7.68	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A0B4J2E0	T cell receptor beta variable 12-4	115	12982	5.84	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	7
+NX_A0A0B4J2F0	Protein PIGBOS1	54	6313	8.04	0	Secreted	NA	NA	NA	NA	NA	PE1	15
+NX_A0A0B4J2F2	Probable serine/threonine-protein kinase SIK1B	783	84930	6.81	0	NA	NA	Probable serine/threonine-protein kinase.	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.	NA	PE2	21
+NX_A0A0B4J2H0	Immunoglobulin heavy variable 1-69D	117	12660	8.64	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0C4DH24	Immunoglobulin kappa variable 6-21	114	12430	6.7	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE3	2
+NX_A0A0C4DH25	Immunoglobulin kappa variable 3D-20	116	12515	4.46	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_A0A0C4DH27	T cell receptor gamma variable 8	118	13335	8.55	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	7
+NX_A0A0C4DH28	T cell receptor gamma variable 4	118	13152	6.71	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	7
+NX_A0A0C4DH29	Immunoglobulin heavy variable 1-3	117	13008	9.59	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0C4DH31	Immunoglobulin heavy variable 1-18	117	12820	8.98	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0C4DH32	Immunoglobulin heavy variable 3-20	117	12673	7.71	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0C4DH33	Immunoglobulin heavy variable 1-24	117	12824	5.04	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0C4DH34	Immunoglobulin heavy variable 4-28	117	13124	9.36	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0C4DH38	Immunoglobulin heavy variable 5-51	117	12675	8.45	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0C4DH39	Immunoglobulin heavy variable 1-58	117	13005	9.34	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0C4DH41	Immunoglobulin heavy variable 4-61	118	13066	9.36	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE3	14
+NX_A0A0C4DH42	Immunoglobulin heavy variable 3-66	116	12698	8.38	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0C4DH43	Immunoglobulin heavy variable 2-70D	119	13312	8.5	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0C4DH55	Immunoglobulin kappa variable 3D-7	119	13148	5.64	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A0C4DH59	T cell receptor beta variable 5-4	114	12518	5.52	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0C4DH62	Immunoglobulin heavy joining 1	17	1910	5.24	0	Secreted;Cell membrane	NA	J region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE4	14
+NX_A0A0C4DH67	Immunoglobulin kappa variable 1-8	115	12537	9.21	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A0C4DH68	Immunoglobulin kappa variable 2-24	120	13079	8.74	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A0C4DH69	Immunoglobulin kappa variable 1-9	117	12715	8.52	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A0C4DH72	Immunoglobulin kappa variable 1-6	117	12697	8.52	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_A0A0C4DH73	Immunoglobulin kappa variable 1-12	117	12645	8.55	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE3	2
+NX_A0A0C5B5G6	Mitochondrial-derived peptide MOTS-c	16	2175	10.27	0	Secreted	NA	Regulates insulin sensitivity and metabolic homeostasis. Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide (AICAR) and the activation of the metabolic regulator 5'-AMP-activated protein kinase (AMPK). Protects against age-dependent and diet-induced insulin resistance as well as diet-induced obesity.	NA	NA	NA	PE1	MT
+NX_A0A0D9SF12	Transmembrane protein CCDC163	145	16203	8.31	1	Membrane	NA	NA	NA	NA	NA	PE2	1
+NX_A0A0G2JMD5	PRAME family member 33	474	55092	8.62	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE3	1
+NX_A0A0G2JMI3	Immunoglobulin heavy variable 1-69-2	117	12871	4.72	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0G2JS06	Immunoglobulin lambda variable 5-39	123	13394	8.84	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	NA	PE1	22
+NX_A0A0J9YVY3	Immunoglobulin heavy variable 7-4-1	117	12849	8.86	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0J9YWL9	Putative testis-expressed protein 13C	993	109806	8.94	0	NA	NA	NA	NA	Belongs to the TEX13 family.	NA	PE5	X
+NX_A0A0J9YWP8	T cell receptor beta joining 1-3	16	1730	4	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0J9YWX3	T cell receptor beta joining 1-6	17	1864	8.49	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0J9YX06	T cell receptor beta joining 1-2	15	1635	8.59	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0J9YX35	Immunoglobulin heavy variable 3-64D	117	12823	7.68	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0J9YX75	T cell receptor beta variable 6-9	114	12484	6.8	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0J9YX94	Paraneoplastic antigen Ma6F	578	60071	4.47	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_A0A0J9YXA8	T cell receptor beta joining 1-1	15	1640	6	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0J9YXG5	T cell receptor beta joining 1-4	16	1741	5.66	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0J9YXM7	T cell receptor beta joining 1-5	16	1770	6.46	0	Cell membrane	NA	J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_A0A0J9YXQ4	Paraneoplastic antigen Ma6E	647	65155	4.62	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_A0A0J9YXX1	Immunoglobulin heavy variable 5-10-1	117	12773	8.46	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_A0A0J9YXY3	T cell receptor beta variable 6-2	114	12525	8.38	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	7
+NX_A0A0J9YY54	Testis-expressed protein 13D	714	78886	7.31	0	NA	NA	NA	NA	Belongs to the TEX13 family.	NA	PE1	X
+NX_A0A0K0K1A3	T cell receptor beta variable 10-1	114	12970	6.36	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0K0K1A5	T cell receptor beta variable 6-5	114	12402	6.01	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	7
+NX_A0A0K0K1B3	T cell receptor beta variable 30	111	12225	8.57	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0K0K1C0	T cell receptor beta variable 11-1	115	12817	4.72	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0K0K1C4	T cell receptor beta variable 27	114	12838	8.45	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0K0K1D8	T cell receptor beta variable 6-1	114	12632	7.64	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0K0K1E9	T cell receptor beta variable 7-7	115	12787	6.71	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0K0K1G6	T cell receptor beta variable 10-3	114	13035	6.58	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0K0K1G8	T cell receptor beta variable 10-2	114	13045	7.75	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A0K2S4Q6	Protein CD300H	201	21806	5.37	1	Membrane;Secreted	NA	May play an important role in innate immunity by mediating a signal for the production of a neutrophil chemoattractant.	NA	Belongs to the CD300 family.	NA	PE1	17
+NX_A0A0U1RQE8	Putative glycine N-acyltransferase-like protein 1B	302	34553	8.56	0	NA	NA	Putative acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.	NA	Belongs to the glycine N-acyltransferase family.	NA	PE1	11
+NX_A0A0U1RQF7	DPEP2 neighbor protein	123	13402	9.67	0	NA	NA	NA	NA	NA	NA	PE1	16
+NX_A0A0U1RQI7	Kruppel-like factor 18	1052	112602	4.73	0	Nucleus	NA	NA	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE2	1
+NX_A0A0U1RQS6	Transmembrane protein 275	177	17236	8.13	2	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_A0A0U1RR11	Centromere protein V-like protein 1	272	29887	10.16	0	NA	NA	NA	NA	Belongs to the Gfa family.	NA	PE2	X
+NX_A0A0U1RR37	Uncharacterized protein C1orf232	186	20280	4.63	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_A0A0U1RRE5	Negative regulator of P-body association	68	7025	9.51	0	P-body	NA	Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process.	NA	NA	NA	PE1	X
+NX_A0A0U1RRI6	Centromere protein V-like protein 3	287	31262	9.8	0	NA	NA	NA	NA	Belongs to the Gfa family.	NA	PE1	X
+NX_A0A0U1RRK4	LBH domain-containing protein 2	108	10701	4.78	0	NA	NA	NA	NA	NA	NA	PE1	14
+NX_A0A0U1RRL7	Protein MMP24OS	71	7680	4.64	0	NA	NA	NA	NA	NA	NA	PE1	20
+NX_A0A0U1RRN3	Putative transmembrane protein SPTY2D1OS	59	6977	6.54	1	Membrane	NA	NA	NA	NA	NA	PE2	11
+NX_A0A140G945	Alpha-crystallin A2 chain	173	19909	5.77	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Acetylation at Lys-70 seems to increase chaperone activity.;Phosphorylation on Ser-122 seems to be developmentally regulated. Absent in the first months of life, it appears during the first 12 years of human lifetime. The relative amount of phosphorylated form versus unphosphorylated form does not change over the lifetime of the individual.;Undergoes age-dependent proteolytical cleavage at the C-terminus. Alpha-crystallin A(1-172) is the most predominant form produced most rapidly during the first 12 years of age and after this age is present in approximately 50% of the lens molecules.;Deamidation of Asn-101 in lens occurs mostly during the first 30 years of age, followed by a small additional amount of deamidation (approximately 5%) during the next approximately 38 years, resulting in a maximum of approximately 50% deamidation during the lifetime of the individual.;O-glycosylated; contains N-acetylglucosamine side chains.	Belongs to the small heat shock protein (HSP20) family.	NA	PE1	21
+NX_A0A183	Late cornified envelope protein 6A	80	9022	9.13	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE2	1
+NX_A0A1B0GTC6	Uncharacterized protein C3orf85	90	10386	5.44	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_A0A1B0GTD5	Testis-expressed protein 49	131	15631	9.56	0	NA	NA	NA	NA	NA	NA	PE1	12
+NX_A0A1B0GTH6	Casein kinase II subunit alpha'-interacting protein	734	81798	10.01	0	Nucleus	NA	May play a role in chromatin regulation of male germ cells.	Phosphorylated by CK2 (casein kinase II), specifically by complexes containing catalytic subunit CSNK2A2.	NA	NA	PE1	3
+NX_A0A1B0GTI1	Coiled-coil domain-containing protein 201	187	20621	9.04	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_A0A1B0GTI8	Transmembrane protein 272	187	21340	5.46	4	Membrane	NA	NA	NA	NA	NA	PE2	13
+NX_A0A1B0GTK4	Protein FAM237A	181	20560	8.96	1	Membrane	NA	NA	NA	NA	NA	PE2	2
+NX_A0A1B0GTK5	Protein FAM236D	79	8682	8.8	0	NA	NA	NA	NA	Belongs to the FAM236 family.	NA	PE2	X
+NX_A0A1B0GTL2	Uncharacterized protein C20orf204	189	20914	11.95	0	NA	NA	NA	NA	NA	NA	PE1	20
+NX_A0A1B0GTQ4	Protein myomixer	84	9607	11.45	1	Cytoplasmic vesicle;Cytosol;Mitochondrion;Cell membrane	NA	Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK. Acts by generating membrane stresses via its extracellular C-terminus, leading to drive fusion pore formation. Acts independently of MYMK. Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers.	NA	Belongs to the MYMX family.	NA	PE2	6
+NX_A0A1B0GTR0	Epididymal protein 13	161	18455	8.6	0	Secreted	NA	NA	NA	NA	NA	PE3	19
+NX_A0A1B0GTR3	Uncharacterized protein CXorf51A	108	12028	10.8	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_A0A1B0GTR4	Putative small proline-rich protein 5	108	11945	8.55	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_A0A1B0GTS1	Heat shock transcription factor, X-linked member 4	333	37155	6.48	0	Nucleus	NA	NA	NA	Belongs to the HSF family.	NA	PE2	X
+NX_A0A1B0GTU1	Zinc finger CCCH domain-containing protein 11B	805	88937	6.4	0	NA	NA	May play a role in mRNA transport.	NA	NA	NA	PE1	1
+NX_A0A1B0GTU2	Cortexin domain-containing 1	59	6734	4.19	1	Membrane	NA	NA	NA	NA	NA	PE2	15
+NX_A0A1B0GTW7	Leishmanolysin-like peptidase 2	788	85397	8.04	1	Membrane	NA	Metalloprotease.	NA	Belongs to the peptidase M8 family.	NA	PE2	14
+NX_A0A1B0GTY4	Testis-expressed protein 50	177	20847	9.36	1	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_A0A1B0GTZ2	Putative coiled-coil domain-containing protein 196	297	34479	8.83	0	NA	NA	NA	NA	NA	NA	PE5	14
+NX_A0A1B0GU29	Small integral membrane protein 28	152	16551	4.52	1	Membrane	NA	NA	NA	NA	NA	PE2	6
+NX_A0A1B0GU33	Testis-expressed protein 53	70	8127	10.53	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_A0A1B0GU71	Uncharacterized protein CFAP97D2	98	11681	10.74	0	NA	NA	NA	NA	Belongs to the CFAP97 family.	NA	PE2	13
+NX_A0A1B0GUA5	Small integral membrane protein 32	103	10859	9.03	1	Membrane	NA	NA	NA	NA	NA	PE2	5
+NX_A0A1B0GUA6	Putative coiled-coil domain-containing protein 195	201	21921	8.34	0	NA	NA	NA	NA	NA	NA	PE5	2
+NX_A0A1B0GUA7	Testis-expressed protein 51	166	18842	7.59	1	Membrane	NA	NA	NA	NA	NA	PE2	2
+NX_A0A1B0GUA9	Uncharacterized protein C13orf46	212	23433	4.84	0	NA	NA	NA	NA	NA	NA	PE1	13
+NX_A0A1B0GUC4	Myocilin opposite strand protein	108	12046	9	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_A0A1B0GUI7	Putative uncharacterized protein BRD3OS	84	9747	9.66	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_A0A1B0GUJ8	Paraneoplastic antigen-like protein 8C	204	22873	9.07	0	NA	NA	NA	NA	Belongs to the PNMA family.	NA	PE2	19
+NX_A0A1B0GUQ0	Protein FAM236A	79	8715	7.8	0	NA	NA	NA	NA	Belongs to the FAM236 family.	NA	PE2	X
+NX_A0A1B0GUS0	Uncharacterized protein C19orf85	222	23875	6.04	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_A0A1B0GUS4	Ubiquitin-conjugating enzyme E2 L5	154	17875	7.67	0	NA	NA	Catalyzes the covalent attachment of ubiquitin to other proteins.	NA	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.	PE1	13
+NX_A0A1B0GUT2	Uncharacterized protein C10orf143	108	11738	9.21	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_A0A1B0GUU1	Transmembrane protein C17orf113	675	72432	5.84	1	Membrane	NA	NA	NA	NA	NA	PE2	17
+NX_A0A1B0GUV7	Testis-expressed protein 48	120	13937	8.99	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_A0A1B0GUW6	Uncharacterized protein SPEM3	1196	128649	8.57	1	Membrane	NA	NA	NA	NA	NA	PE1	17
+NX_A0A1B0GUW7	Small integral membrane protein 27	55	6429	10.13	1	Membrane	NA	NA	NA	NA	NA	PE3	9
+NX_A0A1B0GUX0	Protein ATP6V1FNB	176	20389	9.87	0	NA	NA	NA	NA	NA	NA	PE1	7
+NX_A0A1B0GUY1	MARCO-like protein	285	29775	10.29	0	NA	NA	NA	NA	NA	NA	PE1	5
+NX_A0A1B0GV03	Golgin subfamily A member 6-like protein 7	622	75583	5.31	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE1	15
+NX_A0A1B0GV22	Protein FAM236B	79	8715	7.8	0	NA	NA	NA	NA	Belongs to the FAM236 family.	NA	PE2	X
+NX_A0A1B0GV85	Reelin domain-containing protein 1	526	56837	6.53	1	Membrane	NA	NA	NA	NA	NA	PE2	4
+NX_A0A1B0GV90	Cortexin domain containing 2	55	5988	6	1	Membrane	NA	NA	NA	NA	NA	PE2	1
+NX_A0A1B0GVD1	Protein FAM237B	139	16331	8.63	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_A0A1B0GVG4	Coiled-coil domain-containing protein 194	234	24954	10.03	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_A0A1B0GVG6	Testis-expressed protein 54	124	14093	4.82	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_A0A1B0GVH4	Serine protease-like protein 51	220	25576	8.73	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE2	8
+NX_A0A1B0GVH6	Uncharacterized protein C13orf42	325	37385	9.25	0	NA	NA	NA	NA	NA	NA	PE2	13
+NX_A0A1B0GVH7	IQ domain-containing protein M	501	59586	9.96	0	NA	NA	NA	NA	NA	NA	PE2	4
+NX_A0A1B0GVK7	Protein FAM240A	77	9685	9.92	0	NA	NA	NA	NA	Belongs to the FAM240 family.	NA	PE2	3
+NX_A0A1B0GVM5	Embryonic testis differentiation protein homolog C	59	6800	10.18	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_A0A1B0GVM6	Uncharacterized protein C11orf97	126	13914	9.43	0	Cilium basal body	NA	NA	NA	NA	NA	PE2	11
+NX_A0A1B0GVN3	Uncharacterized protein C2orf92	265	30198	9.03	1	Membrane	NA	NA	NA	NA	NA	PE2	2
+NX_A0A1B0GVQ0	Small regulatory polypeptide of amino acid response	90	9632	8.51	1	Lysosome membrane;Late endosome membrane	NA	Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity).	NA	NA	NA	PE1	9
+NX_A0A1B0GVQ3	Coiled-coil domain-containing protein 200	168	19413	9.33	0	NA	NA	NA	NA	NA	NA	PE1	17
+NX_A0A1B0GVR7	Protein FAM240C	95	10834	10.14	0	Nucleoplasm	NA	NA	NA	Belongs to the FAM240 family.	NA	PE2	2
+NX_A0A1B0GVS7	MyoD family inhibitor domain-containing protein 2	189	21509	4.64	0	NA	NA	NA	NA	Belongs to the MDFI family.	NA	PE2	3
+NX_A0A1B0GVT2	Small integral membrane protein 36	93	10135	5.51	1	Membrane	NA	NA	NA	NA	NA	PE1	17
+NX_A0A1B0GVV1	Small integral membrane protein 35	85	9379	5.56	1	Membrane	NA	NA	NA	NA	NA	PE2	11
+NX_A0A1B0GVX0	LITAF domain-containing protein	72	8245	8.49	0	Membrane	NA	NA	NA	Belongs to the CDIP1/LITAF family.	NA	PE5	16
+NX_A0A1B0GVY4	Small integral membrane protein 31	71	8394	5.19	1	Membrane	NA	NA	NA	NA	NA	PE2	4
+NX_A0A1B0GVZ2	Protein FAM240B	78	9744	8.52	0	NA	NA	NA	NA	Belongs to the FAM240 family.	NA	PE2	9
+NX_A0A1B0GVZ6	Methyl-CpG-binding domain protein 3-like 2B	204	22665	11.53	0	NA	NA	NA	NA	Belongs to the MBD3L family.	NA	PE2	19
+NX_A0A1B0GVZ9	Transmembrane protein 269	245	26874	6.68	5	Membrane	NA	NA	NA	NA	NA	PE2	1
+NX_A0A1B0GW35	Exocyst complex component 1-like	172	20250	6.31	0	NA	NA	NA	NA	NA	NA	PE2	4
+NX_A0A1B0GW54	Small integral membrane protein 39	56	5955	12.4	1	Membrane	NA	NA	NA	NA	NA	PE2	2
+NX_A0A1B0GW64	Small integral membrane protein 33	132	14123	5.14	1	Membrane	NA	NA	NA	NA	NA	PE2	5
+NX_A0A1B0GWB2	Proline rich transmembrane protein 1B	263	26769	4.77	2	Membrane	NA	NA	NA	Belongs to the CD225/Dispanin family.	NA	PE1	9
+NX_A0A1B0GWG4	Serine-rich and transmembrane domain-containing 2	90	10219	6.01	1	Membrane	NA	NA	NA	NA	NA	PE2	X
+NX_A0A1B0GWH4	Heat shock transcription factor, X-linked member 3	333	37128	6.48	0	Nucleus	NA	NA	NA	Belongs to the HSF family.	NA	PE2	X
+NX_A0A1B0GWK0	Parvalbumin-like EF-hand-containing protein	134	15275	5.66	0	NA	NA	NA	NA	Belongs to the parvalbumin family.	NA	PE2	17
+NX_A0A1B0GX31	T cell receptor beta variable 7-6	115	12827	7.72	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A1B0GX49	T cell receptor beta variable 6-4	114	12298	7.68	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	7
+NX_A0A1B0GX51	T cell receptor beta variable 7-8	115	12715	6.71	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A1B0GX56	T cell receptor delta variable 1	115	12955	9.2	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	14
+NX_A0A1B0GX68	T cell receptor beta variable 2	115	13403	4.83	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A1B0GX78	T cell receptor beta variable 12-5	115	12997	6.07	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A1B0GX95	T cell receptor beta variable 7-4	115	12658	9.6	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A1B0GXF2	T cell receptor beta variable 7-2	115	12480	6.05	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	7
+NX_A0A1W2PP97	Thrombospondin type-1 domain-containing protein 8	115	13152	5.79	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_A0A1W2PPF3	Double homeobox protein B	345	40370	6.43	0	Nucleus	NA	NA	NA	NA	NA	PE2	16
+NX_A0A1W2PPG7	Putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14	69	7528	5.14	0	Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the G protein gamma family.	NA	PE5	19
+NX_A0A1W2PPM1	Cytoplasmic polyadenylated homeobox-like	405	45714	6.55	0	Nucleus	NA	NA	NA	NA	NA	PE2	16
+NX_A0A1W2PQ73	ETS domain-containing transcription factor ERF-like	354	37790	6.24	0	Nucleus	NA	NA	NA	Belongs to the ETS family.	NA	PE2	19
+NX_A0A1W2PR19	Glutathione S-transferase theta-4	241	27942	6.51	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.	NA	Belongs to the GST superfamily. Theta family.	NA	PE2	22
+NX_A0A1W2PR48	Transducin-like enhancer protein 7	441	48656	5.58	0	NA	NA	NA	NA	Belongs to the WD repeat Groucho/TLE family.	NA	PE1	16
+NX_A0A1W2PR82	Protein PERCC1	267	29212	4.49	0	NA	NA	Plays a critical role in intestinal function (PubMed:31217582). Acts by promoting the development of enteroendocrine cells (EECs) of the gastrointestinal tract and pancreas (By similarity). It is thereby required for normal enteroendocrine peptide hormone secretion (By similarity).	NA	NA	NA	PE2	16
+NX_A0A1W2PS18	Transmembrane protein PMIS2	150	15819	4.16	2	Membrane	NA	May play a role in spermatozoa mobility.	NA	Belongs to the CD225/Dispanin family.	NA	PE2	19
+NX_A0A286YEV6	Small cysteine and glycine repeat-containing protein 4	105	9792	8.41	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 28 family.	NA	PE1	2
+NX_A0A286YEX9	Small cysteine and glycine repeat-containing protein 10	47	3825	7.96	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 28 family.	NA	PE1	2
+NX_A0A286YEY9	Small cysteine and glycine repeat-containing protein 1	88	8607	8.46	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 28 family.	NA	PE1	2
+NX_A0A286YF01	Small cysteine and glycine repeat-containing protein 7	96	8951	8.36	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 28 family.	NA	PE1	2
+NX_A0A286YF46	Small cysteine and glycine repeat-containing protein 5	85	8201	8.39	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 28 family.	NA	PE1	2
+NX_A0A286YF58	Transmembrane protein 271	385	39128	9.55	4	Membrane	NA	NA	NA	NA	NA	PE2	4
+NX_A0A286YF60	Small cysteine and glycine repeat-containing protein 3	100	9511	8.47	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 28 family.	NA	PE1	2
+NX_A0A286YF77	Small cysteine and glycine repeat-containing protein 6	105	9896	8.45	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 28 family.	NA	PE1	2
+NX_A0A286YFB4	Small cysteine and glycine repeat-containing protein 2	120	10822	8.34	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 28 family.	NA	PE1	2
+NX_A0A286YFG1	Small cysteine and glycine repeat-containing protein 8	108	10123	8.39	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 28 family.	NA	PE1	2
+NX_A0A286YFK9	Small integral membrane protein 38	51	5769	9.62	1	Membrane	NA	NA	NA	NA	NA	PE2	11
+NX_A0A2R8Y4Y8	Oocyte-secreted protein 4B	160	18448	9.41	0	Secreted	NA	NA	NA	Belongs to the PLAC1 family.	NA	PE3	11
+NX_A0A2R8YCJ5	Small integral membrane protein 41	93	9345	4.32	1	Membrane	NA	NA	NA	NA	NA	PE2	12
+NX_A0A2R8YFL7	Oocyte-secreted protein 4A	184	21040	8.19	0	Secreted	NA	NA	NA	Belongs to the PLAC1 family.	NA	PE2	11
+NX_A0A2R8YFM6	Oocyte-secreted protein 3	193	21194	5.48	0	Secreted	NA	NA	NA	Belongs to the PLAC1 family.	NA	PE2	11
+NX_A0A2Z4LIS9	Forkhead box protein O3B	290	29900	4.82	0	Cytosol	NA	NA	NA	NA	NA	PE1	17
+NX_A0A539	T cell receptor beta variable 4-2	114	12890	8.19	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A576	T cell receptor beta variable 3-1	114	12928	8.21	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A577	T cell receptor beta variable 4-1	114	12859	8.48	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A578	T cell receptor beta variable 5-1	114	12600	9.55	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	7
+NX_A0A584	T cell receptor beta variable 11-2	115	12743	8.39	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A589	T cell receptor beta variable 4-3	114	12856	7.63	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A597	T cell receptor beta variable 5-5	114	12550	8.42	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A599	T cell receptor beta variable 5-6	114	12565	5.81	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A5A2	T cell receptor beta variable 5-8	114	12721	6.06	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A5A6	T cell receptor beta variable 11-3	115	12990	4.93	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A5B0	T cell receptor beta variable 14	115	12880	7.75	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A5B6	T cell receptor beta variable 28	114	13166	8.35	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	7
+NX_A0A5B7	T cell receptor beta variable 29-1	111	12190	4.88	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	7
+NX_A0A5B9	T cell receptor beta constant 2	178	19968	6.48	1	Cell membrane	NA	Constant region of T cell receptor (TR) beta chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	7
+NX_A0AUZ9	KAT8 regulatory NSL complex subunit 1-like protein	987	112253	8.69	0	Cytosol	NA	NA	Acetylated on lysine residues by KAT8 upon ionizing radiation-induced DNA damage; deacetylated by HDAC3.	NA	NA	PE1	2
+NX_A0AV02	Solute carrier family 12 member 8	714	78239	5.51	13	Membrane;Nucleoplasm	NA	Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.	NA	Belongs to the SLC12A transporter family.	NA	PE1	3
+NX_A0AV96	RNA-binding protein 47	593	64099	7.56	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	Belongs to the RRM RBM47 family.	NA	PE1	4
+NX_A0AVF1	Intraflagellar transport protein 56	554	64178	6.5	0	Cytoplasm;Nucleus speckle;Cilium;Cytosol;Nucleus;Cytoskeleton	NA	Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.	NA	Belongs to the IFT56 family.	Intraflagellar transport	PE1	7
+NX_A0AVI2	Fer-1-like protein 5	2057	237935	8.3	1	Membrane;Cell membrane	NA	Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.	NA	Belongs to the ferlin family.	NA	PE2	2
+NX_A0AVI4	E3 ubiquitin-protein ligase TM129	362	40464	7.84	3	Endoplasmic reticulum membrane	NA	E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.	NA	Belongs to the TMEM129 family.	Protein modification; protein ubiquitination.;E3 ubiquitin ligases ubiquitinate target proteins	PE1	4
+NX_A0AVK6	Transcription factor E2F8	867	94166	9.11	0	Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.	NA	Belongs to the E2F/DP family.	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	PE1	11
+NX_A0AVT1	Ubiquitin-like modifier-activating enzyme 6	1052	117970	5.76	0	Nucleoplasm;Cytoplasm;Cytosol	NA	May play a key role in ubiquitin system and may influence spermatogenesis and male fertility.;Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation.	NA	Belongs to the ubiquitin-activating E1 family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination & Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	4
+NX_A0FGR8	Extended synaptotagmin-2	921	102357	9.33	2	Cytosol;Endoplasmic reticulum membrane;Cell membrane	NA	Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex.	NA	Belongs to the extended synaptotagmin family.	Glycosphingolipid metabolism	PE1	7
+NX_A0FGR9	Extended synaptotagmin-3	886	100035	8.68	2	Endoplasmic reticulum membrane;Cell membrane	NA	Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.	NA	Belongs to the extended synaptotagmin family.	Glycosphingolipid metabolism	PE1	3
+NX_A0JD32	T cell receptor alpha variable 38-2/delta variable 8	116	13278	4.99	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_A0JD36	T cell receptor delta variable 2	115	12944	6.06	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	14
+NX_A0JD37	T cell receptor delta variable 3	113	12981	5.5	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	14
+NX_A0JLT2	Mediator of RNA polymerase II transcription subunit 19	244	26273	9.83	0	Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 19 family.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	11
+NX_A0JNW5	UHRF1-binding protein 1-like	1464	164199	5.89	0	Cytoplasmic vesicle;Nucleoplasm;Early endosome;Cytosol	NA	NA	NA	NA	NA	PE1	12
+NX_A0JP26	POTE ankyrin domain family member B3	581	65710	6.24	0	NA	NA	NA	NA	Belongs to the POTE family.	NA	PE2	15
+NX_A0M8Q6	Immunoglobulin lambda constant 7	106	11254	8.5	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_A0MZ66	Shootin-1	631	71640	5.27	0	Cell membrane;Growth cone;Perikaryon;Nucleoplasm;Lamellipodium;Filopodium;Cytosol;Axon;Cytoskeleton	NA	Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.	Phosphorylated on Ser-101 and Ser-249 by PAK1 through a CDC42- and RAC1-dependent signaling pathway, which enhances its association with F-actin retrograde flow in filopodia and lamellipodia of axonal growth cones. Phosphorylation on Ser-101 and Ser-249 is increased by netrin-1.	Belongs to the shootin family.	Recycling pathway of L1	PE1	10
+NX_A0PG75	Phospholipid scramblase family member 5	271	30027	5.12	0	NA	NA	NA	NA	Belongs to the phospholipid scramblase family.	NA	PE2	3
+NX_A0PJE2	Dehydrogenase/reductase SDR family member 12	317	35146	6.84	0	Golgi apparatus;Cytoplasmic vesicle;Nucleoplasm	NA	Putative oxidoreductase.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	NA	PE2	13
+NX_A0PJK1	Sodium/glucose cotransporter 5	596	64342	7.55	14	Endoplasmic reticulum;Cell membrane	NA	High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.	NA	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Cellular hexose transport	PE1	17
+NX_A0PJW6	Transmembrane protein 223	202	22049	11.03	2	Membrane;Nucleoplasm;Mitochondrion;Nucleus membrane	NA	NA	NA	Belongs to the TMEM223 family.	NA	PE1	11
+NX_A0PJW8	Death-associated protein-like 1	107	11880	10	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	May play a role in the early stages of epithelial differentiation or in apoptosis.	NA	NA	NA	PE1	2
+NX_A0PJX0	Calcium and integrin-binding family member 4	185	21745	4.64	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_A0PJX2	TLD domain-containing protein 2	215	23912	4.67	0	NA	NA	NA	NA	Belongs to the OXR1 family.	NA	PE1	20
+NX_A0PJX4	Protein shisa-3 homolog	238	25832	6.5	1	Cytosol;Endoplasmic reticulum membrane;Lipid droplet	NA	Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.	NA	Belongs to the shisa family.	NA	PE1	4
+NX_A0PJX8	Transmembrane protein 82	343	37222	8.57	8	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the TMEM82 family.	NA	PE1	1
+NX_A0PJY2	Fez family zinc finger protein 1	475	52038	9.62	0	Nucleoplasm;Cytosol;Nucleus	Hypogonadotropic hypogonadism 22 with or without anosmia	Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	7
+NX_A0PJZ0	Putative ankyrin repeat domain-containing protein 20A5	165	18446	8.26	0	NA	NA	NA	NA	NA	NA	PE5	18
+NX_A0PJZ3	Glucoside xylosyltransferase 2	443	51056	9.79	1	Membrane;Nucleoplasm;Cytoskeleton;Midbody ring	NA	Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.	NA	Belongs to the glycosyltransferase 8 family.	Other types of O-glycan biosynthesis	PE1	3
+NX_A0PK00	Transmembrane protein 120B	339	40246	9.08	6	Nucleus inner membrane;Cytosol;Nucleolus	NA	Necessary for efficient adipogenesis.	NA	Belongs to the TMEM120 family.	NA	PE1	12
+NX_A0PK05	Transmembrane protein 72	275	29891	6.07	4	Membrane	NA	NA	NA	NA	NA	PE1	10
+NX_A0PK11	Clarin-2	232	25446	6.51	4	Membrane	NA	NA	NA	Belongs to the clarin family.	NA	PE2	4
+NX_A0ZSE6	Cell cycle control protein 50C	113	13039	8.2	1	Membrane	NA	NA	NA	Belongs to the CDC50/LEM3 family.	NA	PE2	3
+NX_A1A4F0	Putative uncharacterized protein SLC66A1L	135	15626	9.28	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE2	3
+NX_A1A4G5	Leukemia NUP98 fusion partner 1	178	21321	8.59	0	Cytoplasmic vesicle;Cytosol;Nucleus speckle	NA	NA	NA	NA	NA	PE1	3
+NX_A1A4S6	Rho GTPase-activating protein 10	786	89375	6.75	0	Cytoplasm;Cell membrane;Nucleus membrane;Nucleoplasm;Cytosol;Perinuclear region	NA	GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).	Phosphorylated. Phosphorylated in vitro by constitutive active PKN3.;ARHGAP10 is phosphorylated by PKN3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);ARHGAP10 is phosphorylated by PTK2B (Phosphotyrosine:PTM-0255)	NA	Bacterial invasion of epithelial cells;Rho GTPase cycle;Regulation of PAK-2p34 activity by PS-GAP/RHG10	PE1	4
+NX_A1A4V9	Coiled-coil domain-containing protein 189	331	37921	6.29	0	Cytosol	NA	NA	NA	NA	NA	PE1	16
+NX_A1A4Y4	Immunity-related GTPase family M protein	181	20142	5.23	0	Autophagosome membrane;Cell membrane;Phagosome membrane;Phagocytic cup;Golgi apparatus membrane	Inflammatory bowel disease 19	Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.	Toxoplasmosis	PE1	5
+NX_A1A519	Protein FAM170A	330	37158	5	0	Nucleus	NA	Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).	NA	Belongs to the FAM170 family.	NA	PE1	5
+NX_A1A580	Keratin-associated protein 23-1	65	6892	5.26	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	NA	Keratinization	PE1	21
+NX_A1A5B4	Anoctamin-9	782	90333	8.45	8	Golgi apparatus;Cell membrane	NA	Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22178883). Can inhibit the activity of ANO1 (PubMed:20056604, PubMed:22946059).	NA	Belongs to the anoctamin family.	Stimuli-sensing channels	PE1	11
+NX_A1A5C7	Solute carrier family 22 member 23	686	73748	7.98	10	Membrane;Cytoplasmic vesicle;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	NA	PE1	6
+NX_A1A5D9	BICD family-like cargo adapter 2	508	56834	4.99	0	Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the BICDR family.	NA	PE1	16
+NX_A1E959	Odontogenic ameloblast-associated protein	279	30777	4.49	0	Cytoplasm;Secreted;Nucleoplasm;Cytosol;Nucleus	NA	Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.	O-glycosylated.	Belongs to the ODAM family.	Amyloid fiber formation	PE1	4
+NX_A1IGU5	Rho guanine nucleotide exchange factor 37	675	76278	6.47	0	Cytosol	NA	May act as a guanine nucleotide exchange factor (GEF).	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	5
+NX_A1KXE4	Myelin-associated neurite-outgrowth inhibitor	195	20324	9.26	2	Cytoplasm;Cell membrane;Axon;Perinuclear region;Nucleus	NA	Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.	N-glycosylated.	Belongs to the FAM168 family.	NA	PE1	2
+NX_A1KZ92	Peroxidasin-like protein	1463	163686	7.25	0	Nucleoplasm;Cytoplasm;Cytosol;Secreted	NA	Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.	Phosphorylation by SRC on tyrosine residues is required for targeting to polysomes.	Belongs to the peroxidase family. XPO subfamily.	NA	PE1	8
+NX_A1L020	RNA-binding protein MEX3A	520	54173	7.02	0	Cytoplasm;Cytosol;P-body;Nucleus	NA	RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.	Phosphorylated.	NA	NA	PE1	1
+NX_A1L0T0	Acetolactate synthase-like protein	632	67868	8.42	1	Membrane;Cytoplasmic vesicle;Golgi apparatus	NA	NA	NA	Belongs to the TPP enzyme family.	NA	PE1	19
+NX_A1L157	Tetraspanin-11	253	28245	7.53	4	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE2	12
+NX_A1L162	Glutamate-rich protein 2	156	17672	3.86	0	Cytoplasmic vesicle;Nucleolus	NA	NA	NA	NA	NA	PE1	2
+NX_A1L167	Ubiquitin-conjugating enzyme E2Q-like protein 1	161	18338	7.74	0	Nucleoplasm;Nucleus;Cell membrane	NA	Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.	NA	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis	PE1	5
+NX_A1L168	Uncharacterized protein C20orf202	122	13591	9.13	0	NA	NA	NA	NA	NA	NA	PE2	20
+NX_A1L170	Uncharacterized protein C1orf226	272	29057	5.19	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_A1L188	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8	74	7756	9.56	0	Mitochondrion	NA	Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) (PubMed:27499296). Required to stabilize NDUFAF5 (PubMed:27499296).	NA	NA	NA	PE1	17
+NX_A1L190	Synaptonemal complex central element protein 3	88	10601	4.53	0	Golgi apparatus;Nucleolus;Chromosome;Nucleoplasm;Nucleus	NA	Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.	NA	NA	Meiotic synapsis	PE1	22
+NX_A1L1A6	Immunoglobulin superfamily member 23	192	20591	6.28	1	Membrane;Nucleoplasm;Cell junction	NA	NA	NA	NA	NA	PE2	19
+NX_A1L390	Pleckstrin homology domain-containing family G member 3	1219	134412	6.13	0	Cell membrane;Nucleoplasm;Centrosome;Cytosol;Cytoskeleton	NA	NA	NA	NA	NA	PE1	14
+NX_A1L3X0	Elongation of very long chain fatty acids protein 7	281	33356	9.34	7	Endoplasmic reticulum membrane	NA	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.	NA	Belongs to the ELO family. ELOVL7 subfamily.	Lipid metabolism; fatty acid biosynthesis.;Fatty acid elongation;Synthesis of very long-chain fatty acyl-CoAs	PE1	5
+NX_A1L3X4	Putative metallothionein MT1DP	49	4983	8.38	0	NA	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals.	NA	Belongs to the metallothionein superfamily. Type 1 family.	NA	PE5	16
+NX_A1L429	G antigen 12B/C/D/E	117	12925	4.23	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_A1L443	NUT family member 2F	756	80770	8.51	0	NA	NA	NA	NA	Belongs to the NUT family.	NA	PE2	9
+NX_A1L453	Serine protease 38	326	35356	6.04	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE1	1
+NX_A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	1573	165743	5.71	0	Nucleoplasm;Cytoplasm;Cytosol;Secreted	NA	Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity).	NA	NA	Scavenging by Class B Receptors	PE1	19
+NX_A1L4K1	Fibronectin type III and SPRY domain-containing protein 2	749	85385	4.81	0	Sarcoplasmic reticulum;Cytosol;Perinuclear region;Nucleus	NA	NA	NA	NA	NA	PE1	15
+NX_A1L4L8	PLAC8-like protein 1	177	19885	7.94	0	Nucleoplasm	NA	NA	NA	Belongs to the cornifelin family.	NA	PE2	5
+NX_A1L4Q6	Putative uncharacterized protein FLJ41423	167	18020	6.08	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_A1X283	SH3 and PX domain-containing protein 2B	911	101579	8.82	0	Nucleoplasm;Cytoplasm;Podosome;Nucleolus	Frank-Ter Haar syndrome	Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity).	Phosphorylated in SRC-transformed cells.	Belongs to the SH3PXD2 family.	NA	PE1	5
+NX_A1XBS5	Protein FAM92A	289	33431	5.89	0	Cytoplasm;Mitochondrion;Centriole;Cilium;Cilium basal body;Nucleus	Polydactyly, postaxial, A9	Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis. In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis.	NA	Belongs to the FAM92 family.	NA	PE1	8
+NX_A1YPR0	Zinc finger and BTB domain-containing protein 7C	619	69017	5.09	0	NA	NA	May be a tumor suppressor gene.	NA	NA	NA	PE1	18
+NX_A1Z1Q3	ADP-ribose glycohydrolase MACROD2	425	47421	4.59	0	Nucleoplasm;Nucleolus;Nucleus	NA	Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746).	NA	NA	NA	PE1	20
+NX_A2A288	Probable ribonuclease ZC3H12D	527	58078	8.92	0	Cytoplasm;Nucleoplasm;P-body;Cytosol;Nucleus	NA	May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561).	NA	Belongs to the ZC3H12 family.	NA	PE1	6
+NX_A2A2V5	Serine-rich and transmembrane domain-containing protein 1	107	11458	4.33	1	Membrane;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE2	13
+NX_A2A2Y4	FERM domain-containing protein 3	597	68772	5.97	1	Membrane;Golgi apparatus;Nucleoplasm;Cell membrane	NA	Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.	NA	NA	NA	PE1	9
+NX_A2A2Z9	Ankyrin repeat domain-containing protein 18B	1011	118231	8.35	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_A2A368	Melanoma-associated antigen B16	324	36178	5.25	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_A2A3K4	Protein tyrosine phosphatase domain-containing protein 1	754	84457	7.35	0	Nucleoplasm	NA	May play roles in cilia formation and/or maintenance.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class PTPDC1 subfamily.	NA	PE1	9
+NX_A2A3L6	Tetratricopeptide repeat protein 24	582	63396	9.37	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_A2A3N6	Putative PIP5K1A and PSMD4-like protein	862	95048	5.46	0	Cytoplasm	NA	Has negligible PIP5 kinase activity. Binds to ubiquitinated proteins.	NA	NA	NA	PE5	10
+NX_A2AJT9	BCLAF1 and THRAP3 family member 3	711	83871	9.71	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the BCLAF1/THRAP3 family.	NA	PE1	X
+NX_A2CJ06	Dystrotelin	578	65320	9.18	0	Cell membrane	NA	NA	NA	NA	NA	PE2	2
+NX_A2IDD5	Coiled-coil domain-containing protein 78	438	48521	8.27	0	Sarcoplasmic reticulum;Sarcolemma;Centriole;Perinuclear region	Myopathy, centronuclear, 4	Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome.	NA	Belongs to the CCDC78 family.	NA	PE1	16
+NX_A2NJV5	Immunoglobulin kappa variable 2-29	120	13085	6.7	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_A2PYH4	Probable ATP-dependent DNA helicase HFM1	1435	162610	6.66	0	Golgi apparatus;Cytoplasmic vesicle	Premature ovarian failure 9	Required for crossover formation and complete synapsis of homologous chromosomes during meiosis.	NA	Belongs to the helicase family. SKI2 subfamily.	NA	PE1	1
+NX_A2RRD8	Zinc finger protein 320	509	59326	9.16	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_A2RRH5	WD repeat-containing protein 27	827	90038	8.25	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	6
+NX_A2RRL7	Transmembrane protein 213	107	11520	5.41	1	Membrane	NA	NA	NA	NA	NA	PE2	7
+NX_A2RRP1	Neuroblastoma-amplified sequence	2371	268571	5.65	0	Cytoplasm;Golgi apparatus;Endoplasmic reticulum membrane;Nucleus membrane;Nucleolus;Endoplasmic reticulum	Short stature, optic nerve atrophy, and Pelger-Huet anomaly;Infantile liver failure syndrome 2	Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418).	NA	NA	COPI-dependent Golgi-to-ER retrograde traffic	PE1	2
+NX_A2RTX5	Threonine--tRNA ligase 2, cytoplasmic	802	92646	5.74	0	Cytoplasm;Cytosol;Nucleus	NA	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.	NA	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis	PE1	15
+NX_A2RTY3	Protein HEATR9	570	65681	9.32	0	NA	NA	NA	NA	NA	NA	PE1	17
+NX_A2RU14	Transmembrane protein 218	115	12459	6.7	3	Membrane;Cytosol;Cilium;Cell membrane	NA	May be involved in ciliary biogenesis or function.	NA	Belongs to the TMEM218 family.	NA	PE1	11
+NX_A2RU30	Protein TESPA1	521	59213	5.48	0	Cytoplasm;Endoplasmic reticulum membrane	NA	Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.	May be phosphorylated in response to store-operated Ca(+2) entry.	NA	NA	PE1	12
+NX_A2RU37	Uncharacterized protein C9orf170	121	13369	10.58	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_A2RU48	Single-pass membrane and coiled-coil domain-containing protein 3	225	24877	8.32	1	Membrane	NA	NA	NA	NA	NA	PE1	12
+NX_A2RU49	Hydroxylysine kinase	373	41933	6.36	0	Cytoplasm;Cytosol;Cytoplasmic vesicle	NA	Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.	NA	Belongs to the aminoglycoside phosphotransferase family.	Lysine catabolism	PE1	15
+NX_A2RU54	Homeobox protein HMX2	273	29598	9.16	0	Nucleus	NA	Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development.	NA	Belongs to the HMX homeobox family.	NA	PE1	10
+NX_A2RU67	Protein FAM234B	622	67039	4.88	1	Membrane;Endoplasmic reticulum	NA	NA	NA	Belongs to the FAM234 family.	NA	PE1	12
+NX_A2RUB1	Meiosis-specific coiled-coil domain-containing protein MEIOC	952	107559	6.68	0	Cytoplasm;Cell junction;Nucleus	NA	Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.	NA	NA	NA	PE1	17
+NX_A2RUB6	Coiled-coil domain-containing protein 66	948	109411	8.47	0	Photoreceptor inner segment;Photoreceptor outer segment;Cell junction;Centriolar satellite;Cilium;Cilium basal body;Centrosome;Cytosol;Midbody ring	NA	Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840). Plays a role in retina morphogenesis and/or homeostasis (By similarity).	NA	NA	NA	PE1	3
+NX_A2RUC4	tRNA wybutosine-synthesizing protein 5	315	36548	7.1	0	Nucleus	NA	TRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.	NA	Belongs to the TYW5 family.	tRNA modification; wybutosine-tRNA(Phe) biosynthesis.;Synthesis of wybutosine at G37 of tRNA(Phe)	PE1	2
+NX_A2RUG3	Testis-specific XK-related protein, Y-linked 2	117	12988	8.91	3	Membrane	NA	NA	NA	Belongs to the XK family.	NA	PE2	Y
+NX_A2RUH7	Myosin-binding protein H-like	354	38733	8.65	0	NA	NA	NA	NA	Belongs to the immunoglobulin superfamily. MyBP family.	NA	PE1	1
+NX_A2RUQ5	Uncharacterized protein C17orf102	167	17761	10.63	0	NA	NA	NA	NA	NA	NA	PE2	17
+NX_A2RUR9	Coiled-coil domain-containing protein 144A	1427	165125	5.26	0	NA	NA	NA	NA	Belongs to the CCDC144 family.	NA	PE2	17
+NX_A2RUS2	DENN domain-containing protein 3	1198	135890	6.63	0	Cytoplasm;Cytosol;Cytoplasmic vesicle	NA	Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity).	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	8
+NX_A2RUT3	Transmembrane protein 89	159	17572	10.06	1	Membrane	NA	NA	NA	NA	NA	PE1	3
+NX_A2RUU4	Colipase-like protein 1	121	14057	8.92	0	Secreted	NA	NA	NA	Belongs to the colipase family.	NA	PE2	6
+NX_A2VCK2	Doublecortin domain-containing protein 2B	349	37665	9	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_A2VDF0	Fucose mutarotase	154	16765	5.49	0	NA	NA	Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.	NA	Belongs to the RbsD / FucU family.	GDP-fucose biosynthesis	PE1	10
+NX_A2VDJ0	Transmembrane protein 131-like	1609	179339	6.43	1	Cytoplasm;Cell membrane;Nucleolus;Endoplasmic reticulum;Cytoplasmic vesicle	NA	Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.	NA	Belongs to the TMEM131 family.	NA	PE1	4
+NX_A2VEC9	SCO-spondin	5150	547841	5.66	0	Extracellular space	NA	Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).	NA	Belongs to the thrombospondin family.	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	7
+NX_A3KFT3	Olfactory receptor 2M5	312	35112	8.56	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	1
+NX_A3KMH1	von Willebrand factor A domain-containing protein 8	1905	214824	7.01	0	Cytoplasmic vesicle;Peroxisome;Mitochondrion;Lipid droplet	NA	Exhibits ATPase activity in vitro.	NA	NA	NA	PE1	13
+NX_A3KN83	Protein strawberry notch homolog 1	1393	154312	7.96	0	Nucleoplasm	NA	NA	NA	Belongs to the SBNO family.	NA	PE1	12
+NX_A3QJZ6	PRAME family member 22	481	55489	8.4	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE3	1
+NX_A3QJZ7	PRAME family member 27	478	55206	8.58	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE3	1
+NX_A4D0S4	Laminin subunit beta-4	1761	193540	5.93	0	Basement membrane	NA	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	NA	NA	Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer	PE1	7
+NX_A4D0T2	Uncharacterized protein C7orf66	115	13234	9.3	1	Membrane	NA	NA	NA	NA	NA	PE4	7
+NX_A4D0T7	Small integral membrane protein 30	59	6102	5.93	1	Membrane	NA	NA	NA	NA	NA	PE2	7
+NX_A4D0V7	Cadherin-like and PC-esterase domain-containing protein 1	1026	117491	8.41	0	Endoplasmic reticulum;Nucleoplasm	NA	NA	NA	Belongs to the PC-esterase family.	NA	PE1	7
+NX_A4D0Y5	Uncharacterized protein C7orf77	90	10046	6.55	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_A4D126	D-ribitol-5-phosphate cytidylyltransferase	451	49873	5.86	0	Nucleoplasm;Cytosol;Nucleolus	Muscular dystrophy-dystroglycanopathy limb-girdle C7;Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A7	Cytidylyltransferase required for protein O-linked mannosylation (PubMed:22522420, PubMed:27130732, PubMed:27601598, PubMed:26687144, PubMed:22522421, PubMed:26923585). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:27130732, PubMed:26687144, PubMed:26923585). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:27130732, PubMed:26687144, PubMed:26923585). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (PubMed:26687144). Not Involved in dolichol production (PubMed:26687144).	NA	Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.	Protein modification; protein glycosylation.	PE1	7
+NX_A4D161	Protein FAM221A	298	33083	6.33	0	Cytosol	NA	NA	NA	Belongs to the FAM221 family.	NA	PE1	7
+NX_A4D1B5	Gamma-secretase-activating protein	854	97802	6.38	0	trans-Golgi network;Cytoplasmic vesicle	NA	Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.	The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form.	Belongs to the GSAP family.	NA	PE1	7
+NX_A4D1E1	Zinc finger protein 804B	1349	152573	8.84	0	NA	NA	NA	NA	NA	Generic Transcription Pathway	PE2	7
+NX_A4D1E9	GTP-binding protein 10	387	42933	9.12	0	Nucleolus;Chromosome	NA	May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed.	NA	Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.	NA	PE1	7
+NX_A4D1F6	Leucine-rich repeat and death domain-containing protein 1	860	98035	7.24	0	NA	NA	NA	NA	NA	NA	PE1	7
+NX_A4D1N5	Putative uncharacterized protein FLJ40288	150	16741	7.87	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_A4D1P6	WD repeat-containing protein 91	747	83344	6.15	0	Early endosome membrane;Late endosome membrane	NA	Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).	NA	Belongs to the WD repeat WDR91 family.	NA	PE1	7
+NX_A4D1S0	Killer cell lectin-like receptor subfamily G member 2	409	42851	5.63	1	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	7
+NX_A4D1S5	Ras-related protein Rab-19	217	24400	6.06	0	Cell membrane	NA	NA	NA	Belongs to the small GTPase superfamily. Rab family.	RAB geranylgeranylation	PE1	7
+NX_A4D1T9	Probable inactive serine protease 37	235	26445	9.05	0	Secreted;Acrosome	NA	Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system (PubMed:27649891).	NA	Belongs to the peptidase S1 family.	NA	PE1	7
+NX_A4D1U4	DENN domain-containing protein 11	455	51446	5.18	0	Golgi apparatus	NA	Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity).	NA	Belongs to the DENND11 family.	NA	PE1	7
+NX_A4D1Z8	Grifin	144	15999	6.28	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_A4D250	B-cell acute lymphoblastic leukemia-expressed protein	179	19503	4.86	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_A4D256	Dual specificity protein phosphatase CDC14C	447	51614	8.33	1	Endoplasmic reticulum membrane	NA	Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.	NA	PE1	7
+NX_A4D263	Spermatogenesis-associated protein 48	438	49672	8.67	0	NA	NA	NA	NA	NA	NA	PE1	7
+NX_A4D2B0	Metallo-beta-lactamase domain-containing protein 1	266	27202	4.73	0	NA	NA	NA	NA	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.	NA	PE1	7
+NX_A4D2B8	Putative postmeiotic segregation increased 2-like protein 1	440	47508	8.75	0	NA	NA	NA	NA	Belongs to the DNA mismatch repair MutL/HexB family.	NA	PE5	7
+NX_A4D2G3	Olfactory receptor 2A25	310	34606	8.65	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_A4D2H0	cTAGE family member 15	777	87868	5.15	1	Membrane	NA	NA	NA	Belongs to the cTAGE family.	NA	PE2	7
+NX_A4D2P6	Delphilin	1211	132276	7.11	0	Postsynaptic cell membrane;Cell membrane	NA	Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.	NA	NA	NA	PE1	7
+NX_A4FU01	Myotubularin-related protein 11	709	79545	6.59	0	Centrosome	NA	NA	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	NA	PE1	1
+NX_A4FU28	cTAGE family member 9	777	87953	5.22	1	Membrane	NA	NA	NA	Belongs to the cTAGE family.	NA	PE1	6
+NX_A4FU49	SH3 domain-containing protein 21	640	70519	5.6	0	Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	1
+NX_A4FU69	EF-hand calcium-binding domain-containing protein 5	1503	173404	5.58	0	NA	NA	NA	NA	NA	NA	PE1	17
+NX_A4GXA9	Probable crossover junction endonuclease EME2	379	41178	5.97	0	Nucleus	NA	Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures.	NA	Belongs to the EME1/MMS4 family.	Fanconi anemia pathway;Resolution of D-loop Structures through Holliday Junction Intermediates;Fanconi Anemia Pathway	PE1	16
+NX_A4IF30	Solute carrier family 35 member F4	521	57809	9	10	Membrane;Nucleolus	NA	Putative solute transporter.	NA	Belongs to the SLC35F solute transporter family.	NA	PE2	14
+NX_A4QMS7	Uncharacterized protein C5orf49	147	16991	7.02	0	NA	NA	NA	NA	NA	NA	PE1	5
+NX_A4QN01	Putative uncharacterized protein encoded by LINC01553	128	15288	9.18	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_A4QPB2	Low-density lipoprotein receptor-related protein 5-like protein	252	28483	5.92	0	Nucleoplasm	NA	NA	NA	NA	NA	PE2	22
+NX_A4QPH2	Putative phosphatidylinositol 4-kinase alpha-like protein P2	592	66944	6.68	0	NA	NA	NA	NA	Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.	NA	PE5	22
+NX_A4UGR9	Xin actin-binding repeat-containing protein 2	3374	382300	5.99	0	Nucleoplasm;Cell junction;Cell membrane	NA	Protects actin filaments from depolymerization.	NA	Belongs to the Xin family.	NA	PE1	2
+NX_A5A3E0	POTE ankyrin domain family member F	1075	121445	5.82	0	Cell cortex	NA	NA	NA	In the N-terminal section; belongs to the POTE family.;In the C-terminal section; belongs to the actin family.	NA	PE1	2
+NX_A5D6W6	Fat storage-inducing transmembrane protein 1	292	32207	9.86	6	Endoplasmic reticulum membrane	NA	Plays an important role in lipid droplet accumulation.	NA	Belongs to the FIT family.	Lipid particle organization	PE1	14
+NX_A5D8T8	C-type lectin domain family 18 member A	446	49602	8.47	0	Endoplasmic reticulum;Golgi apparatus;Endosome;Secreted	NA	Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455).	N-glycosylated.	NA	NA	PE1	16
+NX_A5D8V6	Vacuolar protein sorting-associated protein 37C	355	38659	5.19	0	Nucleoplasm;Late endosome membrane;Cytoplasmic vesicle	NA	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.	Phosphorylated by TBK1.	Belongs to the VPS37 family.	Endocytosis;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	11
+NX_A5D8V7	Coiled-coil domain-containing protein 151	595	69140	9.11	0	Centriole;Cilium;Cilium basal body;Nucleoplasm;Cilium axoneme	Ciliary dyskinesia, primary, 30	Ciliary protein involved in outer dynein arm assembly and required for motile cilia function.	NA	NA	NA	PE1	19
+NX_A5D8W1	Cilia- and flagella-associated protein 69	941	105883	6.81	0	Cilium;Flagellum	Spermatogenic failure 24	Cilium- and flagellum-associated protein (PubMed:29606301). In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability (PubMed:29606301).	NA	NA	NA	PE1	7
+NX_A5LHX3	Proteasome subunit beta type-11	300	32530	5.99	0	Cytoplasm;Nucleus	NA	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity).	NA	Belongs to the peptidase T1B family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination & Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	14
+NX_A5PKW4	PH and SEC7 domain-containing protein 1	1024	109543	6.43	0	Cleavage furrow;Cell membrane;Nucleoplasm;Ruffle membrane;Cytosol	NA	Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity).	NA	Belongs to the PSD family.	Endocytosis	PE1	10
+NX_A5PL33	Protein KRBA1	1030	107498	8.09	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	Generic Transcription Pathway	PE1	7
+NX_A5PLK6	Regulator of G-protein signaling protein-like	1076	125688	9.15	1	Membrane	NA	NA	NA	NA	G alpha (i) signalling events;G alpha (q) signalling events;G alpha (z) signalling events	PE1	1
+NX_A5PLL1	Ankyrin repeat domain-containing protein 34B	514	56414	7.61	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	NA	NA	Phosphorylated.	Belongs to the ANKRD34 family.	NA	PE1	5
+NX_A5PLL7	Transmembrane protein 189	270	31135	6.33	3	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	NA	NA	NA	NA	PE1	20
+NX_A5PLN7	Protein FAM149A	773	82698	9.53	0	Golgi apparatus	NA	NA	NA	Belongs to the FAM149 family.	NA	PE1	4
+NX_A5PLN9	Trafficking protein particle complex subunit 13	417	46524	5.4	0	Nucleoplasm;Cell membrane	NA	NA	NA	Belongs to the TRAPPC13 family.	RAB GEFs exchange GTP for GDP on RABs	PE1	5
+NX_A5X5Y0	5-hydroxytryptamine receptor 3E	456	51438	6.46	4	Cell membrane	NA	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily.	Neurotransmitter receptors and postsynaptic signal transmission	PE1	3
+NX_A5YKK6	CCR4-NOT transcription complex subunit 1	2376	266939	6.65	0	Cytosol;P-body;Nucleus	NA	Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity.	NA	Belongs to the CNOT1 family.	RNA degradation;Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	16
+NX_A5YM69	Rho guanine nucleotide exchange factor 35	484	53287	4.27	0	NA	NA	NA	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	7
+NX_A5YM72	Carnosine synthase 1	827	88484	5.83	0	NA	NA	Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.	NA	NA	Arginine and proline metabolism;Histidine metabolism;beta-Alanine metabolism;Histidine catabolism	PE1	11
+NX_A6BM72	Multiple epidermal growth factor-like domains protein 11	1044	110844	5.78	1	Basolateral cell membrane;Cell membrane	NA	May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).	NA	Belongs to the MEGF family.	NA	PE1	15
+NX_A6H8M9	Cadherin-related family member 4	788	85827	5.24	1	Membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).	NA	NA	NA	PE1	3
+NX_A6H8Y1	Transcription factor TFIIIB component B'' homolog	2624	293885	5.06	0	Nucleoplasm;Nucleus	Deafness, autosomal recessive, 112	General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site.	Phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.	NA	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	5
+NX_A6H8Z2	Protein FAM221B	402	45394	5.37	0	NA	NA	NA	NA	Belongs to the FAM221 family.	NA	PE1	9
+NX_A6NC05	Glutaredoxin-like protein C5orf63	138	15764	9.26	0	Mitochondrion	NA	NA	NA	Belongs to the glutaredoxin family. YDR286C subfamily.	NA	PE1	5
+NX_A6NC42	Developmental pluripotency-associated 5 protein	116	13498	9.26	0	Cytoplasm	NA	Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity).	NA	Belongs to the KHDC1 family.	NA	PE1	6
+NX_A6NC51	Modulator of macroautophagy TMEM150B	233	25701	9.05	6	Autophagosome membrane;Cell membrane;Endosome membrane	NA	Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859).	NA	Belongs to the DRAM/TMEM150 family.	NA	PE2	19
+NX_A6NC57	Ankyrin repeat domain-containing protein 62	917	106446	6.25	0	NA	NA	NA	NA	NA	NA	PE2	18
+NX_A6NC62	Putative RBAK downstream neighbor protein	111	12297	9.05	0	NA	NA	NA	NA	NA	NA	PE5	7
+NX_A6NC78	Putative golgin subfamily A member 8I	632	71330	7.14	0	Golgi stack membrane	NA	May be involved in maintaining Golgi structure.	NA	Belongs to the GOLGA8 family.	NA	PE5	15
+NX_A6NC86	phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein	204	21926	8.37	0	Cytoplasmic vesicle;Secreted	NA	NA	NA	Belongs to the CNF-like-inhibitor family.	NA	PE1	19
+NX_A6NC97	Putative protein FAM172B	362	41969	8.59	1	Membrane	NA	NA	NA	Belongs to the FAM172 family.	NA	PE5	3
+NX_A6NC98	Coiled-coil domain-containing protein 88B	1476	164809	5.09	0	Cytoplasm;Golgi apparatus;Microtubule organizing center;Membrane;Endoplasmic reticulum;Nucleoplasm;Centrosome;Cytosol	NA	Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099).	NA	Belongs to the CCDC88 family.	NA	PE1	11
+NX_A6NCC3	Golgin subfamily A member 8O	632	71536	5.98	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE1	15
+NX_A6NCE7	Microtubule-associated proteins 1A/1B light chain 3 beta 2	125	14628	8.73	0	Autophagosome membrane;Endomembrane system;Cytoskeleton	NA	Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).	The precursor molecule is cleaved by APG4B/ATG4B to form LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form LC3-II.	Belongs to the ATG8 family.	NA	PE2	12
+NX_A6NCF5	Kelch-like protein 33	533	57810	6.98	0	NA	NA	NA	NA	NA	NA	PE2	14
+NX_A6NCF6	Putative MAGE domain-containing protein MAGEA13P	341	37899	5.98	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_A6NCI4	von Willebrand factor A domain-containing protein 3A	1184	134020	8.74	0	Secreted	NA	NA	NA	NA	NA	PE1	16
+NX_A6NCI5	Putative transmembrane protein encoded by LINC00862	91	10419	6.94	1	Membrane	NA	NA	NA	NA	NA	PE5	1
+NX_A6NCI8	Uncharacterized protein C2orf78	922	100170	9.12	0	NA	NA	NA	NA	NA	NA	PE2	2
+NX_A6NCJ1	Uncharacterized protein C19orf71	209	24176	9.14	0	Endoplasmic reticulum;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	19
+NX_A6NCK2	Tripartite motif-containing protein 43B	446	52310	8.07	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE2	2
+NX_A6NCL1	Geminin coiled-coil domain-containing protein 1	334	37887	5.79	0	Nucleus	NA	Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity).	Highly phosphorylated by CDK2; stimulates initiation of DNA replication.	Belongs to the GEMC1 family.	NA	PE1	3
+NX_A6NCL2	Leucine-rich colipase-like protein 1	159	17834	8.55	0	NA	NA	NA	NA	NA	NA	PE1	12
+NX_A6NCL7	Ankyrin repeat domain-containing protein 33B	494	53975	8.27	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	5
+NX_A6NCM1	IQ and AAA domain-containing protein 1-like	818	95061	9.22	0	NA	NA	NA	NA	Belongs to the AAA ATPase family.	NA	PE1	7
+NX_A6NCN2	Putative keratin-87 protein	255	29117	5.64	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	NA	PE5	12
+NX_A6NCN8	Testis-expressed protein 52	305	35334	10.17	0	NA	NA	NA	NA	NA	NA	PE1	12
+NX_A6NCQ9	RING finger protein 222	220	23767	9.08	1	Membrane	NA	NA	NA	NA	NA	PE1	17
+NX_A6NCS4	Homeobox protein Nkx-2.6	301	32121	9.91	0	Nucleus	Conotruncal heart malformations	Acts as a transcriptional activator (PubMed:15649947). In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development.	NA	Belongs to the NK-2 homeobox family.	NA	PE1	8
+NX_A6NCS6	Uncharacterized protein C2orf72	295	30481	8.73	0	Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	2
+NX_A6NCV1	Olfactory receptor 6C74	312	35253	8.95	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_A6NCW0	Ubiquitin carboxyl-terminal hydrolase 17-like protein 3	530	59536	7.83	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	8
+NX_A6NCW7	Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4	530	59636	7.1	0	Endoplasmic reticulum;Nucleus	NA	NA	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	8
+NX_A6ND01	Sperm-egg fusion protein Juno	250	28672	5.88	0	Cell membrane	NA	Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.	The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm.	Belongs to the folate receptor family.	Endocytosis;Post-translational modification: synthesis of GPI-anchored proteins	PE1	11
+NX_A6ND36	Protein FAM83G	823	90835	5.97	0	Cytosol;Nucleus	NA	May regulate the bone morphogenetic proteins (BMP) pathway.	BMP signaling induces the phosphorylation of PAWS1 by BMPR1A at Ser-610, Ser-614 and Ser-616. In response to BMP phosphorylation at Ser-610 is necessary for the activation of SMAD4-independent BMP target genes such as NEDD9 and ASNS.	Belongs to the FAM83 family.	NA	PE1	17
+NX_A6ND48	Olfactory receptor 14I1	311	35175	8.89	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_A6ND91	Putative L-aspartate dehydrogenase	283	29946	6.79	0	Nucleoplasm;Spindle;Cytoskeleton	NA	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.	NA	Belongs to the L-aspartate dehydrogenase family.	Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.	PE1	19
+NX_A6NDA9	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2	550	60168	5.65	1	Membrane	NA	NA	NA	NA	NA	PE1	10
+NX_A6NDB9	Paralemmin-3	673	71695	4.53	0	Cytoplasm;Nucleoplasm;Nucleus;Cell membrane	NA	ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling.	Palmitoylated on Cys-667 and Cys-669 and prenylated on Cys-670; which is required for membrane association.	Belongs to the paralemmin family.	NA	PE1	19
+NX_A6NDD5	Synapse differentiation-inducing gene protein 1-like	238	25796	4.55	2	cis-Golgi network;Membrane	NA	NA	NA	Belongs to the CD225/Dispanin family.	NA	PE2	14
+NX_A6NDE4	RNA-binding motif protein, Y chromosome, family 1 member B	496	55835	9.96	0	Nucleus	NA	RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.	NA	NA	NA	PE2	Y
+NX_A6NDE8	G antigen 12H	117	12924	4.33	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE2	X
+NX_A6NDG6	Glycerol-3-phosphate phosphatase	321	34006	5.85	0	Nucleus	NA	Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity).	NA	Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.	Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Glycolysis	PE1	16
+NX_A6NDH6	Olfactory receptor 5H15	313	35352	8.77	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	3
+NX_A6NDI0	Putative tripartite motif-containing protein 49B	452	52747	7.06	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE2	11
+NX_A6NDK9	Golgin subfamily A member 6C	693	79884	5.31	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE1	15
+NX_A6NDL7	Putative methyltransferase-like protein 21E pseudogene	271	31188	5.73	0	NA	NA	Protein-lysine methyltransferase.	NA	Belongs to the methyltransferase superfamily. METTL21 family.	NA	PE5	13
+NX_A6NDL8	Olfactory receptor 6C68	312	35296	9.01	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_A6NDN3	Golgin subfamily A member 6B	693	79913	5.4	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE1	15
+NX_A6NDN8	Putative ubiquitin-like protein FUBI-like protein ENSP00000310146	102	10909	8.84	0	NA	NA	NA	NA	NA	NA	PE4	11
+NX_A6NDP7	Myeloid-associated differentiation marker-like protein 2	307	32967	8.82	7	Membrane	NA	NA	NA	Belongs to the MAL family.	NA	PE2	17
+NX_A6NDR6	Putative homeobox protein Meis3-like 1	274	30204	4.84	0	Nucleus	NA	NA	NA	Belongs to the TALE/MEIS homeobox family.	NA	PE5	17
+NX_A6NDS4	TBC1 domain family member 3B	549	62320	9.25	0	Cell membrane	NA	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).	Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.;Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.	NA	NA	PE2	17
+NX_A6NDU8	UPF0600 protein C5orf51	294	33620	5.15	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the UPF0600 family.	NA	PE1	5
+NX_A6NDV4	Transmembrane protein 8B	472	51941	8.35	7	Cytoplasm;Mitochondrion;Cell membrane;Endoplasmic reticulum;Cytoplasmic vesicle;Nucleus	NA	May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.	Is N-glycosylated.	Belongs to the TMEM8 family.	NA	PE1	9
+NX_A6NDX4	Putative transmembrane protein ENSP00000320207	124	13671	8.96	1	Membrane	NA	NA	NA	NA	NA	PE5	15
+NX_A6NDX5	Putative zinc finger protein 840	716	83235	9.69	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE5	20
+NX_A6NDY0	Embryonic polyadenylate-binding protein 2	278	30386	4.84	0	Cytoplasm	NA	Binds the poly(A) tail of mRNA.	NA	NA	mRNA surveillance pathway;Influenza A	PE2	16
+NX_A6NDY2	Putative protein FAM90A10P	464	49635	9.76	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_A6NDZ8	Putative methyl-CpG-binding domain protein 3-like 4	208	23121	11.45	0	NA	NA	NA	NA	Belongs to the MBD3L family.	NA	PE5	19
+NX_A6NE01	Protein FAM186A	2351	262758	8.66	0	NA	NA	NA	NA	Belongs to the FAM186 family.	NA	PE1	12
+NX_A6NE02	BTB/POZ domain-containing protein 17	478	52471	8.91	0	Secreted	NA	NA	NA	NA	NA	PE1	17
+NX_A6NE21	Putative protein FAM90A18P/FAM90A19P	464	49680	9.93	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_A6NE52	WD repeat-containing protein 97	1622	180307	7.56	0	NA	NA	NA	NA	NA	NA	PE1	8
+NX_A6NE82	Putative methyl-CpG-binding domain protein 3-like 3	208	23095	11.45	0	NA	NA	NA	NA	Belongs to the MBD3L family.	NA	PE5	19
+NX_A6NEC2	Puromycin-sensitive aminopeptidase-like protein	478	53747	5.17	0	NA	NA	Aminopeptidase with broad substrate specificity to several peptides.	NA	Belongs to the peptidase M1 family.	NA	PE1	17
+NX_A6NED2	RCC1 domain-containing protein 1	376	40079	5.18	0	Cytosol;Cell membrane;Chromosome	NA	Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 (PubMed:24981860). Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8 (PubMed:28455245).	Specifically hydroxylated (with R stereochemistry) at C-3 of ARG-141 by KDM8.	NA	NA	PE1	15
+NX_A6NEE1	Pleckstrin homology domain-containing family D member 1	506	59203	6.1	0	NA	NA	NA	NA	Belongs to the PLEKHD1 family.	NA	PE1	14
+NX_A6NEF3	Golgin subfamily A member 6-like protein 4	574	67563	4.81	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE2	15
+NX_A6NEH6	Transmembrane protein 247	219	25168	5.51	2	Membrane	NA	NA	NA	NA	NA	PE1	2
+NX_A6NEH8	Putative uncharacterized protein encoded by ZNF503-AS2	195	20902	11.72	0	NA	NA	NA	NA	NA	NA	PE5	10
+NX_A6NEK1	Arrestin domain-containing protein 5	342	38383	6.22	0	NA	NA	NA	NA	Belongs to the arrestin family.	NA	PE1	19
+NX_A6NEL2	Ankyrin repeat domain-containing protein SOWAHB	793	85742	9.64	0	Nucleolus	NA	NA	NA	Belongs to the SOWAH family.	NA	PE1	4
+NX_A6NEL3	Putative protein FAM86C2P	165	18478	8.19	0	NA	NA	NA	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.	NA	PE5	11
+NX_A6NEM1	Golgin subfamily A member 6-like protein 9	432	49193	5.08	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE1	15
+NX_A6NEN9	Uncharacterized protein CXorf65	183	21305	10.33	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_A6NEQ0	RNA-binding motif protein, Y chromosome, family 1 member E	496	55759	9.95	0	Nucleus	NA	RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.	NA	NA	NA	PE2	Y
+NX_A6NEQ2	Protein FAM181B	426	42657	5.39	0	Mitochondrion;Nucleus membrane	NA	NA	NA	Belongs to the FAM181 family.	NA	PE2	11
+NX_A6NER0	TBC1 domain family member 3F	549	62185	9.24	0	Cell membrane	NA	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).	Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.;Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.	NA	NA	PE2	17
+NX_A6NER3	G antigen 12J	117	12896	4.22	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_A6NES4	Maestro heat-like repeat-containing protein family member 2A	1674	189561	6.23	0	Cytosol	NA	NA	NA	NA	NA	PE1	2
+NX_A6NET4	Olfactory receptor 5K3	321	36711	8.32	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	3
+NX_A6NEV1	Proline-rich protein 23A	266	28155	4.57	0	NA	NA	NA	NA	Belongs to the PRR23 family.	NA	PE2	3
+NX_A6NEW6	Putative protein FAM90A16P/FAM90A17P	464	49759	9.95	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_A6NEY3	Putative golgin subfamily A member 6-like protein 3	463	55643	4.81	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE5	15
+NX_A6NEY8	Putative prolyl-tRNA synthetase associated domain-containing protein 1	169	18658	5.82	0	NA	NA	NA	NA	Belongs to the PRORSD1 family.	NA	PE5	2
+NX_A6NF01	Putative nuclear envelope pore membrane protein POM 121B	834	83015	9.95	0	Nuclear pore complex	NA	Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity).	NA	Belongs to the POM121 family.	NA	PE5	7
+NX_A6NF34	Anthrax toxin receptor-like	631	70629	8.78	1	Membrane	NA	NA	NA	Belongs to the ATR family.	NA	PE1	10
+NX_A6NF36	Coiled-coil domain-containing protein 182	153	17536	6.19	0	NA	NA	NA	NA	NA	NA	PE1	17
+NX_A6NF83	Nuclear protein 2	97	11356	10.5	0	Nucleus	NA	Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells (PubMed:25899918). Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation (PubMed:25899918). Plays a role as a negative regulator of the protumoral factor NUPR1 (PubMed:25899918).	NA	Belongs to the NUPR family.	NA	PE1	7
+NX_A6NF89	Olfactory receptor 6C6	314	35963	8.98	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_A6NFA0	Protein FAM205C	338	37613	8.24	1	Membrane	NA	NA	NA	NA	NA	PE1	9
+NX_A6NFA1	Metalloprotease TIKI2	517	57421	6.19	1	Cell membrane	NA	Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.	NA	Belongs to the TIKI family.	NA	PE1	1
+NX_A6NFC5	Transmembrane protein 235	223	23360	5.56	3	Membrane;Endoplasmic reticulum	NA	NA	N-glycosylated.	Belongs to the PMP-22/EMP/MP20 family.	NA	PE2	17
+NX_A6NFC9	Putative olfactory receptor 2W5	320	35528	6.35	4	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	1
+NX_A6NFD8	Hairy and enhancer of split-related protein HELT	242	26913	9.39	0	Nucleus	NA	Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'.	NA	Belongs to the HEY family.	NA	PE2	4
+NX_A6NFE2	Single-pass membrane and coiled-coil domain-containing protein 2	343	39487	4.74	1	Membrane	NA	NA	NA	NA	NA	PE2	12
+NX_A6NFE3	EF-hand calcium-binding domain-containing protein 10	127	14721	5.28	0	NA	NA	NA	NA	NA	NA	PE1	7
+NX_A6NFF2	Putative nucleosome assembly protein 1-like 6	107	12045	6.13	0	NA	NA	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE5	X
+NX_A6NFH5	Fatty acid-binding protein 12	140	15565	7.71	0	NA	NA	May play a role in lipid transport.	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Triglyceride catabolism	PE1	8
+NX_A6NFI3	Zinc finger protein 316	1004	108437	5.18	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	7
+NX_A6NFK2	Glutaredoxin domain-containing cysteine-rich protein 2	248	28284	6.26	0	Stereocilium	Deafness, autosomal recessive, 101	Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection.	NA	Belongs to the GRXCR1 family.	NA	PE2	5
+NX_A6NFN3	RNA binding protein fox-1 homolog 3	312	33873	6.71	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).	NA	NA	NA	PE1	17
+NX_A6NFN9	Protein ANKUB1	502	56600	9.29	0	NA	NA	NA	NA	NA	NA	PE2	3
+NX_A6NFQ2	TRPM8 channel-associated factor 2	919	100906	6.75	0	Cell junction;Cell membrane	NA	Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.	NA	Belongs to the TCAF family.	NA	PE1	7
+NX_A6NFQ7	Divergent paired-related homeobox	191	21648	9.55	0	Nucleus	NA	Putative transcription factor.	NA	Belongs to the paired homeobox family.	NA	PE2	19
+NX_A6NFR6	Uncharacterized protein C5orf60	353	39250	9.54	1	Membrane	NA	NA	NA	NA	NA	PE1	5
+NX_A6NFT4	Cilia- and flagella-associated protein 73	308	35914	7.01	0	Nucleoplasm;Cilium axoneme;Nucleolus;Cytoplasmic vesicle	NA	May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.	NA	Belongs to the CFAP73 family.	NA	PE1	12
+NX_A6NFU0	Ig-like V-type domain-containing protein FAM187A	413	47349	8.23	1	Membrane	NA	NA	NA	Belongs to the FAM187 family.	NA	PE1	17
+NX_A6NFU8	Pyroglutamyl-peptidase 1-like protein	196	21631	8.26	0	NA	NA	NA	NA	Belongs to the peptidase C15 family.	NA	PE2	15
+NX_A6NFX1	Major facilitator superfamily domain-containing protein 2B	504	53743	9.1	10	Cell membrane	NA	Cation-dependent lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Does not transport lysophosphatidylcholine (LPC) (By similarity).	NA	Belongs to the major facilitator superfamily.	NA	PE1	2
+NX_A6NFY4	Nuclear envelope integral membrane protein 2	417	48664	8.63	5	Nucleoplasm;Nucleus inner membrane	NA	NA	NA	Belongs to the NEMP family.	NA	PE1	2
+NX_A6NFY7	Succinate dehydrogenase assembly factor 1, mitochondrial	115	12806	11.39	0	Mitochondrion matrix;Mitochondrion	Mitochondrial complex II deficiency	Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954417, PubMed:19465911). Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants (PubMed:24954417). May act together with SDHAF3 (PubMed:24954417). Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (PubMed:26749241).	NA	Belongs to the complex I LYR family. SDHAF1 subfamily.	NA	PE1	19
+NX_A6NFZ4	Protein FAM24A	105	11258	8.08	0	Secreted	NA	NA	NA	Belongs to the FAM24 family.	NA	PE1	10
+NX_A6NG13	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D	374	43743	9.62	1	Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis.	NA	Belongs to the glycosyltransferase 54 family.	NA	PE2	4
+NX_A6NGA9	Transmembrane protein 202	273	31353	8.84	4	Membrane	NA	NA	NA	NA	NA	PE2	15
+NX_A6NGB0	Transmembrane protein 191C	347	39292	8.72	1	Membrane	NA	NA	NA	Belongs to the TMEM191 family.	NA	PE2	22
+NX_A6NGB7	Transmembrane protein 221	291	30293	8.62	4	Membrane;Nucleus membrane	NA	NA	NA	NA	NA	PE1	19
+NX_A6NGB9	WAS/WASL-interacting protein family member 3	483	49458	10.16	0	Cytoplasm;Mitochondrion	NA	May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).	NA	Belongs to the verprolin family.	Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs	PE1	7
+NX_A6NGC4	TLC domain-containing protein 2	264	28733	10.14	6	Cytoplasmic vesicle;Nucleolus;Cell membrane	NA	Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349).	NA	Belongs to the TLCD family.	NA	PE1	17
+NX_A6NGD5	Zinc finger and SCAN domain-containing protein 5C	496	55729	8.32	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE2	19
+NX_A6NGE4	DDB1- and CUL4-associated factor 8-like protein 1	600	67373	4.75	0	NA	NA	NA	NA	Belongs to the WD repeat DCAF8 family.	NA	PE1	X
+NX_A6NGE7	Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	173	19130	5.78	0	Peroxisome	NA	Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.	NA	Belongs to the OHCU decarboxylase family.	Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.;Purine metabolism;Metabolic pathways	PE5	13
+NX_A6NGG3	Putative uncharacterized protein C9orf92	77	8520	9.6	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_A6NGG8	Photoreceptor cilium actin regulator	1288	139655	8.4	0	Photoreceptor inner segment;Photoreceptor outer segment	Retinitis pigmentosa 54	Plays an essential role for normal photoreceptor cell maintenance and vision.	NA	NA	NA	PE1	2
+NX_A6NGH7	Coiled-coil domain-containing protein 160	325	38277	5.35	0	NA	NA	NA	NA	Belongs to the CCDC160 family.	NA	PE1	X
+NX_A6NGH8	Ankyrin repeat domain-containing protein 61	418	46141	9.1	0	Nucleoplasm	NA	NA	NA	NA	NA	PE2	7
+NX_A6NGJ6	Tripartite motif-containing protein 64	449	51566	5.01	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE2	11
+NX_A6NGK3	G antigen 10	116	12651	4.3	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_A6NGN4	PRAME family member 25	478	55354	8.95	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE3	1
+NX_A6NGN9	IgLON family member 5	336	36795	6.96	0	Secreted	NA	NA	NA	Belongs to the immunoglobulin superfamily. IgLON family.	NA	PE1	19
+NX_A6NGQ2	Oocyte-expressed protein homolog	149	17170	6.59	0	Cytoplasm	NA	As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.	NA	Belongs to the KHDC1 family.	NA	PE1	6
+NX_A6NGR9	Maestro heat-like repeat-containing protein family member 6	719	77186	9.88	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	8
+NX_A6NGS2	Glutamate-rich protein 4	130	14477	4.26	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	19
+NX_A6NGU5	Putative glutathione hydrolase 3 proenzyme	568	61502	6.68	1	Membrane	NA	Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.	Cleaved by autocatalysis into a large and a small subunit.	Belongs to the gamma-glutamyltransferase family.	Sulfur metabolism; glutathione metabolism.;Aflatoxin activation and detoxification;Glutathione synthesis and recycling	PE5	22
+NX_A6NGU7	Putative uncharacterized protein encoded by LINC01546	62	7222	10.44	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_A6NGW2	Putative stereocilin-like protein	1772	192437	5.26	0	Secreted	NA	NA	NA	Belongs to the stereocilin family.	NA	PE5	15
+NX_A6NGY1	Protein FRG2-like-2	282	30798	7.09	0	Nucleus	NA	NA	NA	Belongs to the FRG2 family.	NA	PE2	3
+NX_A6NGY3	Uncharacterized protein C5orf52	159	17908	10.21	0	NA	NA	NA	NA	NA	NA	PE1	5
+NX_A6NGY5	Olfactory receptor 51F1	319	35849	8.3	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_A6NGZ8	Small integral membrane protein 9	99	10777	8.46	1	Cell membrane	NA	NA	NA	NA	NA	PE2	X
+NX_A6NH00	Olfactory receptor 2T8	312	34659	8.66	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_A6NH11	Glycolipid transfer protein domain-containing protein 2	291	31642	10.19	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the GLTP family.	NA	PE1	17
+NX_A6NH13	Putative uncharacterized protein DNAJC9-AS1	148	15587	9.94	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_A6NH21	Serine incorporator 4	518	56870	8.75	10	Membrane	NA	Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.	NA	Belongs to the TDE1 family.	Serine biosynthesis	PE2	15
+NX_A6NH52	Golgi apparatus membrane protein TVP23 homolog A	213	24111	6.51	4	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the TVP23 family.	NA	PE2	16
+NX_A6NH57	Putative ADP-ribosylation factor-like protein 5C	179	20591	5.44	0	NA	NA	Binds and exchanges GTP and GDP.	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE2	17
+NX_A6NHA9	Olfactory receptor 4C46	309	34533	8.19	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_A6NHC0	Calpain-8	703	79144	5.1	0	Golgi apparatus;Cytoplasm;Nucleus membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).	Undergoes autolytic cleavage between Ala-5 and Ala-6 which gives rise to fragments extending from Ala-6 to the C-terminus, Ala-6 to the EF-hand 2 domain and from Ala-6 to the beginning of domain III.	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	1
+NX_A6NHG4	D-dopachrome decarboxylase-like protein	134	14195	5.89	0	Cytoplasm	NA	May have lyase activity.	NA	Belongs to the MIF family.	NA	PE2	22
+NX_A6NHG9	Olfactory receptor 5H14	310	35099	8.72	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	3
+NX_A6NHJ4	Zinc finger protein 860	632	73757	9.46	0	Nucleoplasm;Nucleus;Nucleolus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	3
+NX_A6NHL2	Tubulin alpha chain-like 3	446	49909	5.68	0	Cytoskeleton	NA	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).	Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear.;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold.	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;MHC class II antigen presentation;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	10
+NX_A6NHM9	Putative DBH-like monooxygenase protein 2	499	56320	4.65	0	NA	NA	NA	NA	Belongs to the copper type II ascorbate-dependent monooxygenase family.	NA	PE5	7
+NX_A6NHN0	Otolin-1	477	49422	8.6	0	Extracellular matrix	NA	Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics.	NA	Belongs to the OTOL1 family.	NA	PE2	3
+NX_A6NHN6	Nuclear pore complex-interacting protein family member B15	443	51267	10.5	0	Secreted	NA	NA	NA	Belongs to the NPIP family.	NA	PE1	16
+NX_A6NHP3	Speedy protein E2B	402	48290	9.78	0	NA	NA	NA	NA	Belongs to the Speedy/Ringo family.	NA	PE2	7
+NX_A6NHQ2	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1	334	34803	10.35	0	Nucleolus	NA	S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity).	By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).	Belongs to the methyltransferase superfamily. Fibrillarin family.	NA	PE1	5
+NX_A6NHQ4	Elongin BC and Polycomb repressive complex 2-associated protein	379	39322	9.77	0	Nucleoplasm;Cytosol;Nucleus;Chromosome	NA	Scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation.	NA	NA	NA	PE1	17
+NX_A6NHR8	Putative protein FAM47D	397	46757	9.11	0	NA	NA	NA	NA	Belongs to the FAM47 family.	NA	PE5	X
+NX_A6NHR9	Structural maintenance of chromosomes flexible hinge domain-containing protein 1	2005	226374	6.95	0	Nucleoplasm;Nucleus;Chromosome	Facioscapulohumeral muscular dystrophy 2;Bosma arhinia microphthalmia syndrome	Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:25294876, PubMed:24790221). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876).	Sumoylated with SUMO1.	Belongs to the SMC family. Highly divergent.	NA	PE1	18
+NX_A6NHS1	Putative uncharacterized protein ENSP00000347057	94	10211	4.1	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_A6NHS7	MANSC domain-containing protein 4	340	37879	8.33	1	Membrane	NA	NA	NA	NA	NA	PE2	12
+NX_A6NHT5	Homeobox protein HMX3	357	37825	7.85	0	Nucleoplasm;Centriolar satellite;Nucleus	NA	Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity).	NA	Belongs to the HMX homeobox family.	NA	PE1	10
+NX_A6NHX0	Cytosolic arginine sensor for mTORC1 subunit 2	329	36056	5.02	0	Cytosol	NA	Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.	NA	Belongs to the GATS family.	NA	PE1	7
+NX_A6NHY2	Ankyrin repeat and death domain-containing protein 1B	528	59088	8.33	0	NA	NA	NA	NA	NA	NA	PE2	5
+NX_A6NHY6	Putative uncharacterized protein C9orf118	69	7904	8.42	0	NA	NA	NA	NA	NA	NA	PE4	9
+NX_A6NHZ5	Leucine-rich repeat-containing protein 14B	514	56758	6.74	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the PRAME family. LRRC14 subfamily.	NA	PE1	5
+NX_A6NI03	Putative tripartite motif-containing protein 64B	449	51557	5.1	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE5	11
+NX_A6NI15	Mesogenin-1	193	20778	9.03	0	Nucleus	NA	Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity).	NA	NA	NA	PE2	2
+NX_A6NI28	Rho GTPase-activating protein 42	874	98569	8.18	0	Cytosol;Nucleus speckle	NA	May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.	NA	NA	Rho GTPase cycle	PE1	11
+NX_A6NI47	Putative POTE ankyrin domain family member M	508	57067	6.64	0	NA	NA	NA	NA	Belongs to the POTE family.	NA	PE2	14
+NX_A6NI56	Coiled-coil domain-containing protein 154	667	75408	8.47	0	Golgi apparatus;Early endosome;Cell membrane	NA	NA	NA	NA	NA	PE1	16
+NX_A6NI61	Protein myomaker	221	24699	8.98	7	Cell membrane;Golgi apparatus membrane	Carey-Fineman-Ziter syndrome	Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:28681861). Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX. Acts independently of MYMX (By similarity). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (By similarity). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers (By similarity).	Palmitoylated at the C-terminus; palmitoylation promotes localization to the Golgi apparatus.	Belongs to the TMEM8 family.	NA	PE1	9
+NX_A6NI72	Putative neutrophil cytosol factor 1B	391	44817	9.2	0	Cytoplasm	NA	May be required for activation of the latent NADPH oxidase (necessary for superoxide production).	NA	NA	NA	PE5	7
+NX_A6NI73	Leukocyte immunoglobulin-like receptor subfamily A member 5	299	32755	6.5	1	Secreted;Cell membrane	NA	May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_A6NI79	Coiled-coil domain-containing protein 69	296	34796	5.57	0	Golgi apparatus;Cell membrane;Spindle;Midbody;Cytoskeleton	NA	May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.	NA	Belongs to the CCDC69 family.	NA	PE1	5
+NX_A6NI86	Golgin subfamily A member 6-like protein 10	522	60902	4.83	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE2	15
+NX_A6NI87	Protein chibby homolog 3	242	27343	10.65	0	NA	NA	NA	NA	Belongs to the chibby family.	NA	PE1	5
+NX_A6NIE6	Putative RRN3-like protein RRN3P2	340	38035	5.02	0	NA	NA	NA	NA	Belongs to the RRN3 family.	NA	PE5	16
+NX_A6NIE9	Putative serine protease 29	313	34063	6.58	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE5	16
+NX_A6NIH7	Protein unc-119 homolog B	251	28137	5.45	0	Mitochondrion;Cilium;Cytosol;Spindle;Cytoskeleton	NA	Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.	NA	Belongs to the PDE6D/unc-119 family.	Trafficking of myristoylated proteins to the cilium	PE1	12
+NX_A6NIJ5	Putative protein FAM90A20P	464	50026	9.93	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_A6NIJ9	Olfactory receptor 6C70	312	35468	9.17	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_A6NIK2	Leucine-rich repeat-containing protein 10B	292	32714	6.88	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	11
+NX_A6NIL9	Putative uncharacterized protein CRYM-AS1	109	12312	8.89	1	Membrane	NA	NA	NA	NA	NA	PE5	16
+NX_A6NIM6	Solute carrier family 15 member 5	579	65263	7.77	11	Membrane	NA	Proton oligopeptide cotransporter.	NA	Belongs to the PTR2/POT transporter (TC 2.A.17) family.	NA	PE1	12
+NX_A6NIN4	RING finger protein 227	190	21006	9.23	0	NA	NA	NA	NA	NA	NA	PE2	17
+NX_A6NIR3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5	686	75492	6.28	0	NA	NA	Putative GTPase-activating protein.	NA	Belongs to the centaurin gamma-like family.	NA	PE2	10
+NX_A6NIU2	Putative uncharacterized protein encoded by LINC01549	74	8470	4.97	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_A6NIV6	Leucine-rich repeat and IQ domain-containing protein 4	560	63977	8.43	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_A6NIX2	Wilms tumor protein 1-interacting protein	430	45124	8.53	0	P-body;Nucleus;Adherens junction	NA	Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).	NA	Belongs to the zyxin/ajuba family.	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	PE1	19
+NX_A6NIY4	Speedy protein E5	402	47997	9.98	0	NA	NA	NA	NA	Belongs to the Speedy/Ringo family.	NA	PE2	7
+NX_A6NIZ1	Ras-related protein Rap-1b-like protein	184	20925	5.37	0	Cytosol;Cell membrane	NA	NA	NA	Belongs to the small GTPase superfamily. Ras family.	NA	PE2	5
+NX_A6NJ08	Putative methyl-CpG-binding domain protein 3-like 5	208	22976	11.47	0	NA	NA	NA	NA	Belongs to the MBD3L family.	NA	PE5	19
+NX_A6NJ46	Homeobox protein Nkx-6.3	265	28948	9.3	0	Nucleus	NA	Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.	NA	NA	NA	PE2	8
+NX_A6NJ64	Putative nuclear pore complex-interacting protein family member B2	397	45575	9.95	0	Nucleus	NA	NA	NA	Belongs to the NPIP family.	NA	PE5	16
+NX_A6NJ69	IgA-inducing protein homolog	53	5937	9.13	0	Cytoplasmic vesicle;Secreted	NA	Enhances IgA secretion from B-cells stimulated via CD40.	NA	NA	NA	PE2	5
+NX_A6NJ78	Probable methyltransferase-like protein 15	407	46121	8.8	0	Golgi apparatus;Cytoskeleton;Cell membrane	NA	Probable S-adenosyl-L-methionine-dependent methyltransferase.	NA	Belongs to the methyltransferase superfamily. RsmH family.	NA	PE1	11
+NX_A6NJ88	Putative SAGE1-like protein	616	69022	5.68	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_A6NJB7	Proline-rich protein 19	356	38716	10.48	0	Nucleoplasm;Nucleolus;Mitochondrion;Nucleus	NA	NA	NA	NA	NA	PE1	19
+NX_A6NJG2	Ankyrin repeat domain-containing protein SOWAHD	315	33803	9.62	0	NA	NA	NA	NA	Belongs to the SOWAH family.	NA	PE1	X
+NX_A6NJG6	Arginine-fifty homeobox	315	35617	6.84	0	Nucleus	NA	Putative transcription factor.	NA	Belongs to the paired homeobox family.	NA	PE2	3
+NX_A6NJI1	Uncharacterized protein C11orf86	115	13172	11.47	0	NA	NA	NA	NA	NA	NA	PE2	11
+NX_A6NJI9	Leucine-rich repeat-containing protein 72	287	33656	8.92	0	NA	NA	NA	NA	NA	NA	PE1	7
+NX_A6NJJ6	UPF0575 protein C19orf67	358	39779	4.78	0	NA	NA	NA	NA	Belongs to the UPF0575 family.	NA	PE2	19
+NX_A6NJL1	Zinc finger and SCAN domain-containing protein 5B	495	55826	8.88	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE2	19
+NX_A6NJQ4	Putative protein FAM90A8P	464	49661	9.91	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_A6NJR5	Putative speedy protein-like protein 3	290	34699	5.99	0	NA	NA	NA	NA	Belongs to the Speedy/Ringo family.	NA	PE5	7
+NX_A6NJT0	Homeobox protein unc-4 homolog	531	53690	6.74	0	Nucleoplasm;Nucleus	NA	Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity).	NA	Belongs to the paired homeobox family. Unc-4 subfamily.	NA	PE1	7
+NX_A6NJU9	Nuclear pore complex-interacting protein family member B13	1138	125964	9.9	1	Membrane	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_A6NJV1	Protein FAM166C	201	23421	10	0	Cytoplasmic vesicle;Nucleus membrane	NA	NA	NA	Belongs to the FAM166C family.	NA	PE1	2
+NX_A6NJW4	Leucine-rich repeat-containing protein 3C	275	29314	6.15	1	Membrane	NA	NA	NA	Belongs to the LRRC3 family.	NA	PE2	17
+NX_A6NJW9	T-cell surface glycoprotein CD8 beta-2 chain	210	23703	9.88	1	Cell membrane	NA	Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing (By similarity).	NA	NA	NA	PE2	2
+NX_A6NJY1	Putative SLC9B1-like protein SLC9B1P1	282	30828	7.66	7	Membrane	NA	NA	NA	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	NA	PE5	Y
+NX_A6NJY4	Putative transmembrane protein LOC100289255	79	8713	4.43	2	Membrane	NA	NA	NA	NA	NA	PE5	17
+NX_A6NJZ3	Olfactory receptor 6C65	312	35198	8.87	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_A6NJZ7	RIMS-binding protein 3C	1639	180950	6.34	0	Cytoskeleton	NA	Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development.	NA	Belongs to the RIMBP family.	NA	PE1	22
+NX_A6NK02	Putative tripartite motif-containing protein 75	468	53678	7.79	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE5	4
+NX_A6NK06	Cis-aconitate decarboxylase	481	52628	7.01	0	Mitochondrion	NA	Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.	NA	Belongs to the PrpD family.	NA	PE1	13
+NX_A6NK44	Glyoxalase domain-containing protein 5	160	18322	7.7	0	Mitochondrion	NA	NA	NA	Belongs to the glyoxalase I family.	NA	PE1	X
+NX_A6NK53	Zinc finger protein 233	670	76861	8.61	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_A6NK58	Putative lipoyltransferase 2, mitochondrial	231	25195	8.63	0	Cytoplasmic vesicle;Mitochondrion;Centrosome	Encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes, which catalyze essential redox reactions (PubMed:28757203). Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity).	NA	Belongs to the LipB family.	Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.;Lipoic acid metabolism;Metabolic pathways;Glyoxylate metabolism and glycine degradation	PE1	11
+NX_A6NK59	Ankyrin repeat and SOCS box protein 14	587	65331	6.24	0	NA	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination & Proteasome degradation;Neddylation	PE2	3
+NX_A6NK75	Zinc finger protein 98	572	65799	9.33	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE2	19
+NX_A6NK89	Ras association domain-containing protein 10	507	56900	5.29	0	Spindle pole;Cytoplasmic vesicle;Cytosol;Centrosome	NA	Plays an important role in regulating embryonic neurogenesis.	NA	NA	NA	PE1	11
+NX_A6NK97	Solute carrier family 22 member 20	555	60459	8.63	11	Membrane	NA	Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter (By similarity).	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	NA	PE2	11
+NX_A6NKB5	Pecanex-like protein 2	2137	237277	6.29	15	Membrane;Endoplasmic reticulum	NA	May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H).	NA	Belongs to the pecanex family.	NA	PE1	1
+NX_A6NKC0	Putative protein FAM90A7P	464	49804	9.88	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_A6NKC9	SH2 domain-containing protein 7	451	49807	5.99	0	NA	NA	NA	NA	NA	NA	PE2	15
+NX_A6NKD2	Testis-specific Y-encoded protein 2	308	35100	5.3	0	NA	NA	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE2	Y
+NX_A6NKD9	Coiled-coil domain-containing protein 85C	419	45210	6.48	0	Tight junction;Adherens junction;Nucleus speckle;Cell junction	NA	May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity).	NA	Belongs to the CCDC85 family.	NA	PE1	14
+NX_A6NKF1	SAC3 domain-containing protein 1	404	43553	9.04	0	Cytosol;Spindle;Centrosome	NA	Involved in centrosome duplication and mitotic progression.	NA	Belongs to the SAC3 family.	NA	PE1	11
+NX_A6NKF2	AT-rich interactive domain-containing protein 3C	412	44073	5.34	0	Nucleus	NA	NA	NA	NA	NA	PE1	9
+NX_A6NKF7	Transmembrane protein 88B	163	17097	8.53	2	Membrane	NA	NA	NA	Belongs to the TMEM88 family.	NA	PE1	1
+NX_A6NKG5	Retrotransposon-like protein 1	1358	155048	5.09	2	Membrane;Cytosol	NA	Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta.	NA	NA	NA	PE1	14
+NX_A6NKH3	Putative 60S ribosomal protein L37a-like protein	93	10583	10.22	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL43 family.	NA	PE5	11
+NX_A6NKK0	Olfactory receptor 5H1	313	35387	8.8	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	3
+NX_A6NKL6	Transmembrane protein 200C	621	63928	10.1	2	Membrane;Cytoskeleton	NA	NA	NA	Belongs to the TMEM200 family.	NA	PE1	18
+NX_A6NKN8	Purkinje cell protein 4-like protein 1	68	7476	6.28	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the PCP4 family.	NA	PE1	1
+NX_A6NKP2	Putative short-chain dehydrogenase/reductase family 42E member 2	422	46869	9.66	0	NA	NA	NA	NA	Belongs to the 3-beta-HSD family.	NA	PE2	16
+NX_A6NKQ9	Choriogonadotropin subunit beta variant 1	187	20468	9.02	0	Secreted	NA	NA	NA	Belongs to the glycoprotein hormones subunit beta family.	NA	PE2	19
+NX_A6NKT7	RanBP2-like and GRIP domain-containing protein 3	1758	197487	5.95	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_A6NKU9	Speedy protein E3	549	63895	6.06	0	NA	NA	NA	NA	Belongs to the Speedy/Ringo family.	NA	PE2	7
+NX_A6NKW6	Protein shisa-like-2B	160	17663	5.88	1	Membrane	NA	NA	NA	Belongs to the shisa family.	NA	PE2	5
+NX_A6NKX1	Protein FAM223B	122	13778	10.05	0	NA	NA	NA	NA	Belongs to the FAM223 family.	NA	PE3	X
+NX_A6NKX4	Putative solute carrier family 22 member 31	556	58815	9.89	12	Membrane	NA	Organic anion transporter that mediates the uptake of ions.	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	NA	PE1	16
+NX_A6NL05	Protein FAM74A7	159	18299	9.63	1	Membrane	NA	NA	NA	Belongs to the FAM74 family.	NA	PE3	9
+NX_A6NL08	Olfactory receptor 6C75	312	35372	9.29	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	12
+NX_A6NL26	Olfactory receptor 5B21	309	34174	6.73	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_A6NL46	Putative UPF0607 protein ENSP00000332738	340	37797	10.95	0	NA	NA	NA	NA	Belongs to the UPF0607 family.	NA	PE3	6
+NX_A6NL82	Protein FAM183A	134	15996	8.67	0	NA	NA	NA	NA	Belongs to the FAM183 family.	NA	PE1	1
+NX_A6NL88	Protein shisa-7	538	56214	10.06	1	Cytosol;Postsynaptic density membrane	NA	Regulator of long-term synaptic potentiation specifically involved in the formation and retrieval of hippocampus-dependent contextual fear memory. Probably regulates induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses by affecting the recruitment of AMPA-type glutamate receptor (AMPAR) at postsynaptic density.	NA	Belongs to the shisa family.	NA	PE1	19
+NX_A6NL99	Putative aquaporin-7-like protein 3	342	37357	7.83	8	Membrane	NA	NA	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family.	NA	PE5	9
+NX_A6NLC5	UPF0524 protein C3orf70	250	27769	4.85	0	Cytosol	NA	NA	NA	Belongs to the UPF0524 family.	NA	PE1	3
+NX_A6NLC8	Putative TAF11-like protein ENSP00000332601	198	21962	5.72	0	NA	NA	NA	NA	Belongs to the TAF11 family.	NA	PE1	5
+NX_A6NLE4	Small integral membrane protein 23	172	20025	4.76	1	Cell membrane	NA	NA	NA	NA	NA	PE2	5
+NX_A6NLF2	Elongin-A3 member D	546	59772	9.86	0	Nucleus	NA	SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).	NA	NA	Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes	PE3	18
+NX_A6NLI5	Tripartite motif-containing protein 64C	450	51540	5.3	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE2	11
+NX_A6NLJ0	C2 calcium-dependent domain-containing protein 4B	364	38769	11.07	0	Nucleus	NA	May be involved in inflammatory process. May regulate cell architecture and adhesion.	NA	Belongs to the C2CD4 family.	NA	PE1	15
+NX_A6NLP5	Tetratricopeptide repeat protein 36	189	20896	5.02	0	Nucleoplasm	NA	NA	NA	Belongs to the TTC36 family.	NA	PE1	11
+NX_A6NLU0	Ret finger protein-like 4A	287	32238	7.89	0	Cytoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	19
+NX_A6NLU5	V-set and transmembrane domain-containing protein 2B	285	30297	7.88	1	Membrane	NA	NA	NA	NA	NA	PE1	19
+NX_A6NLW8	Double homeobox protein A	204	23817	9.51	0	Nucleus	NA	Putative transcription factor.	NA	Belongs to the paired homeobox family.	NA	PE2	19
+NX_A6NLX3	Speedy protein E4	237	27806	4.93	0	NA	NA	NA	NA	Belongs to the Speedy/Ringo family.	NA	PE2	17
+NX_A6NLX4	Transmembrane protein 210	147	15516	4.19	1	Membrane	NA	NA	NA	NA	NA	PE1	9
+NX_A6NM03	Olfactory receptor 2AG2	316	35270	8.79	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_A6NM10	Aquaporin-12B	295	31475	8.18	6	Membrane	NA	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.	NA	PE1	2
+NX_A6NM11	Leucine-rich repeat-containing protein 37A2	1700	188393	5.33	1	Membrane	NA	NA	NA	Belongs to the LRRC37A family.	NA	PE1	17
+NX_A6NM28	Zinc finger protein 92 homolog	416	45791	10.23	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	X
+NX_A6NM36	Leucine-rich repeat-containing protein 30	301	34034	9.48	0	NA	NA	NA	NA	NA	NA	PE2	18
+NX_A6NM43	Putative T-complex protein 1 subunit theta-like 1	557	59514	5.91	0	Cytoplasm	NA	Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.	NA	Belongs to the TCP-1 chaperonin family.	NA	PE5	7
+NX_A6NM45	Putative claudin-24	220	24421	4.87	4	Tight junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	NA	PE5	4
+NX_A6NM62	Leucine-rich repeat-containing protein 53	1247	140742	8.11	1	Membrane	NA	NA	NA	NA	NA	PE2	1
+NX_A6NM66	Uncharacterized protein encoded by LINC01548	108	11668	8.23	0	NA	NA	NA	NA	NA	NA	PE4	21
+NX_A6NM76	Olfactory receptor 6C76	312	35119	9.04	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_A6NMA1	Putative uncharacterized protein TRPC5OS	111	12326	3.47	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_A6NMB1	Sialic acid-binding Ig-like lectin 16	481	52992	9.28	1	Membrane	NA	Putative adhesion molecule that mediates sialic-acid dependent binding to cells.	NA	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	DAP12 interactions	PE2	19
+NX_A6NMB9	Putative fidgetin-like protein 2	653	66603	6.3	0	NA	NA	NA	NA	Belongs to the AAA ATPase family.	NA	PE5	12
+NX_A6NMD0	Interferon-induced transmembrane protein 10	228	24599	6.59	2	Cell membrane	NA	NA	NA	Belongs to the CD225/Dispanin family.	NA	PE1	11
+NX_A6NMD2	Golgin subfamily A member 8J	632	71775	8.5	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE2	15
+NX_A6NMK7	Putative cleavage and polyadenylation specificity factor subunit 4-like protein	179	20727	8.93	0	NA	NA	NA	NA	Belongs to the CPSF4/YTH1 family.	NA	PE2	17
+NX_A6NMK8	Protein INSYN2B	535	59204	8.39	0	NA	NA	NA	NA	Belongs to the INSYN2 family.	NA	PE1	5
+NX_A6NML5	Transmembrane protein 212	194	21425	8.15	5	Membrane;Endoplasmic reticulum;Nucleolus	NA	NA	NA	NA	NA	PE2	3
+NX_A6NMN3	Protein FAM170B	283	32092	4.67	0	Acrosome outer membrane;Acrosome	NA	Plays a role in fertilization through the acrosome reaction.	NA	Belongs to the FAM170 family.	NA	PE1	10
+NX_A6NMS3	Olfactory receptor 5K4	321	36711	8.44	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	3
+NX_A6NMS7	Leucine-rich repeat-containing protein 37A	1700	188258	5.32	1	Membrane	NA	NA	NA	Belongs to the LRRC37A family.	NA	PE1	17
+NX_A6NMT0	Homeobox protein DBX1	343	37283	9.54	0	Nucleus	NA	Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).	NA	Belongs to the H2.0 homeobox family.	NA	PE1	11
+NX_A6NMU1	Olfactory receptor 52A4	304	34901	8.28	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	11
+NX_A6NMX2	Eukaryotic translation initiation factor 4E type 1B	242	27596	6.68	0	NA	NA	Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure.	NA	Belongs to the eukaryotic initiation factor 4E family.	RNA transport;mTOR signaling pathway;Insulin signaling pathway	PE1	5
+NX_A6NMY6	Putative annexin A2-like protein	339	38659	6.49	0	Basement membrane;Melanosome	NA	Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.	NA	Belongs to the annexin family.	NA	PE5	9
+NX_A6NMZ2	Sentan	147	16468	8.43	0	Cilium	NA	May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.	NA	Belongs to the S-100 family.	NA	PE1	3
+NX_A6NMZ5	Olfactory receptor 4C45	311	35341	7.99	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_A6NMZ7	Collagen alpha-6(VI) chain	2263	247173	6.44	0	Extracellular matrix	NA	Collagen VI acts as a cell-binding protein.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the type VI collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	3
+NX_A6NN06	Putative UPF0633 protein MGC21881	94	10596	11.9	0	NA	NA	NA	NA	Belongs to the UPF0633 family.	NA	PE5	9
+NX_A6NN14	Zinc finger protein 729	1252	145022	9.58	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_A6NN73	Golgin subfamily A member 8C	597	67128	8.72	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE3	15
+NX_A6NN90	Uncharacterized protein C2orf81	582	63239	5.44	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	2
+NX_A6NN92	Putative gap junction epsilon-1 protein	205	23755	8.68	4	Cell membrane	NA	Mediates calcium-independent ATP release, suggesting activity as a hemichannel. Does not form functional gap junctions.	NA	Belongs to the connexin family. Beta-type (group I) subfamily.	NA	PE5	6
+NX_A6NNA2	Serine/arginine repetitive matrix protein 3	597	65249	11.68	0	Cytoskeleton;Cell membrane	NA	May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911).	NA	Belongs to the CWC21 family.	NA	PE1	7
+NX_A6NNA5	Dorsal root ganglia homeobox protein	263	28672	8.74	0	Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.	NA	Belongs to the paired homeobox family.	NA	PE2	10
+NX_A6NNB3	Interferon-induced transmembrane protein 5	132	14378	8.48	2	Cell membrane	Osteogenesis imperfecta 5	Required for normal bone mineralization.	Palmitoylated.	Belongs to the CD225/Dispanin family.	NA	PE1	11
+NX_A6NNC1	Putative POM121-like protein 1-like	897	94058	10.28	1	Membrane	NA	NA	NA	Belongs to the POM121 family.	NA	PE5	5
+NX_A6NND4	Olfactory receptor 2AT4	320	35503	6.21	7	Cell membrane	NA	Olfactory receptor (PubMed:24999593, PubMed:30228264). Activated by the synthetic sandalwood odorant sandalore (PubMed:24999593, PubMed:30228264). Endogenous ligand is unknown (Probable). The activity of this receptor is propably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs (PubMed:24999593, PubMed:30228264). Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes (PubMed:24999593). Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases (PubMed:30228264).	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE1	11
+NX_A6NNE9	E3 ubiquitin-protein ligase MARCH11	402	43878	6.47	2	Cytoplasmic vesicle membrane	NA	E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.	NA	NA	Protein modification; protein ubiquitination.	PE1	5
+NX_A6NNF4	Zinc finger protein 726	738	85539	9.27	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_A6NNH2	Protein FAM90A27P	459	49646	9.97	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE1	19
+NX_A6NNJ1	Putative protein FAM90A9P	464	49738	9.91	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_A6NNL0	NUT family member 2B	878	93984	8.12	0	NA	NA	NA	NA	Belongs to the NUT family.	NA	PE2	10
+NX_A6NNL5	Uncharacterized protein C15orf61	157	18091	9.9	0	Cytoplasmic vesicle;Cytosol;Secreted;Nucleolus	NA	NA	NA	NA	NA	PE1	15
+NX_A6NNM3	RIMS-binding protein 3B	1639	180952	6.34	0	Cytoskeleton	NA	Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development.	NA	Belongs to the RIMBP family.	NA	PE1	22
+NX_A6NNM8	Tubulin polyglutamylase TTLL13P	815	93645	9.12	0	NA	NA	Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity).	NA	Belongs to the tubulin--tyrosine ligase family.	Carboxyterminal post-translational modifications of tubulin	PE1	15
+NX_A6NNN8	Putative sodium-coupled neutral amino acid transporter 8	435	46731	7.42	11	Membrane	Foveal hypoplasia 2	Putative sodium-dependent amino acid/proton antiporter.	NA	Belongs to the amino acid/polyamine transporter 2 family.	NA	PE1	16
+NX_A6NNP5	Coiled-coil domain-containing protein 169	214	25253	9.33	0	NA	NA	NA	NA	Belongs to the CCDC169 family.	NA	PE2	13
+NX_A6NNS2	Dehydrogenase/reductase SDR family member 7C	312	34878	8.72	0	Secreted	NA	Putative oxidoreductase.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	NA	PE1	17
+NX_A6NNT2	Uncharacterized protein C16orf96	1141	125041	6.58	0	NA	NA	NA	NA	NA	NA	PE1	16
+NX_A6NNV3	Putative speedy protein E16	312	37499	8.38	0	NA	NA	NA	NA	Belongs to the Speedy/Ringo family.	NA	PE5	7
+NX_A6NNW6	Enolase 4	625	68465	5.64	0	Nucleoplasm;Mitochondrion	NA	May be required for sperm motility and function.	NA	Belongs to the enolase family.	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.	PE1	10
+NX_A6NNX1	RIIa domain-containing protein 1	92	10810	9.57	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_A6NNY8	Ubiquitin carboxyl-terminal hydrolase 27	438	49630	6.75	0	Nucleoplasm;Cytosol;Nucleus;Cytoplasmic vesicle	Mental retardation, X-linked 105	Deubiquitinase that can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal. By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity.	NA	Belongs to the peptidase C19 family.	NA	PE1	X
+NX_A6NNZ2	Tubulin beta 8B	444	49573	4.75	0	Cytoskeleton	NA	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).	Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).	Belongs to the tubulin family.	Separation of Sister Chromatids;MHC class II antigen presentation;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	18
+NX_A6NP11	Zinc finger protein 716	495	57006	9.34	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	7
+NX_A6NP61	ZAR1-like protein	321	36010	9.27	0	NA	NA	NA	NA	Belongs to the ZAR1 family.	NA	PE1	13
+NX_A6PVC2	Protein monoglycylase TTLL8	850	94676	8.55	0	Cilium;Cilium axoneme;Cytoskeleton	NA	Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity).	NA	NA	Carboxyterminal post-translational modifications of tubulin	PE2	22
+NX_A6PVI3	Nuclear cap-binding protein subunit 2-like	153	17685	6.89	0	NA	NA	NA	NA	Belongs to the RRM NCBP2 family.	NA	PE2	X
+NX_A6PVL3	Kinocilin	124	12832	9.51	2	Membrane	NA	May play a role in stabilizing dense microtubular networks or in vesicular trafficking.	NA	NA	NA	PE2	1
+NX_A6PVS8	Leucine-rich repeat and IQ domain-containing protein 3	624	73675	9.73	0	Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	1
+NX_A6PVY3	Protein FAM177B	158	18145	4.84	0	NA	NA	NA	NA	Belongs to the FAM177 family.	NA	PE2	1
+NX_A6QL63	Ankyrin repeat and BTB/POZ domain-containing protein BTBD11	1104	120884	6.36	1	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	12
+NX_A6QL64	Ankyrin repeat domain-containing protein 36A	1941	217465	8.84	0	NA	NA	NA	NA	Belongs to the ANKRD36 family.	NA	PE1	2
+NX_A6XGL0	YjeF N-terminal domain-containing protein 3	299	32585	5.75	0	Mitochondrion	NA	May play a role in spermiogenesis and oogenesis.	NA	NA	NA	PE1	19
+NX_A6ZKI3	Retrotransposon Gag-like protein 8C	113	13171	4.94	0	NA	NA	NA	NA	Belongs to the FAM127 family.	NA	PE1	X
+NX_A7E2F4	Golgin subfamily A member 8A	631	70117	5.89	0	Golgi stack membrane	NA	May be involved in maintaining Golgi structure.	NA	Belongs to the GOLGA8 family.	NA	PE2	15
+NX_A7E2S9	Putative ankyrin repeat domain-containing protein 30B-like	258	28549	7.05	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_A7E2U8	UPF0602 protein C4orf47	309	34376	9.64	0	Cytoplasmic vesicle;Centrosome	NA	NA	NA	Belongs to the UPF0602 family.	NA	PE1	4
+NX_A7E2V4	Zinc finger SWIM domain-containing protein 8	1837	197297	6.35	0	Cytosol;Cell membrane	NA	NA	NA	NA	Regulation of expression of SLITs and ROBOs	PE1	10
+NX_A7E2Y1	Myosin-7B	1983	225845	5.81	0	Membrane	NA	Involved in muscle contraction.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tight junction;Viral myocarditis	PE1	20
+NX_A7KAX9	Rho GTPase-activating protein 32	2087	230529	6.27	0	Golgi apparatus;Dendritic spine;Cell cortex;Endoplasmic reticulum membrane;Endosome membrane;Nucleolus;Membrane;Nucleoplasm;Postsynaptic density;Golgi apparatus membrane	NA	Has higher GAP activity (By similarity).;GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation.	Is phosphorylated on multiple tyrosine residues by FYN. Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors (By similarity). Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity (By similarity).;ARHGAP32 is phosphorylated by NTRK1;ARHGAP32 is phosphorylated by FYN	Belongs to the PX domain-containing GAP family.	Rho GTPase cycle	PE1	11
+NX_A7MBM2	Protein dispatched homolog 2	1401	152003	8.18	12	Membrane;Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	Belongs to the dispatched family.	Release of Hh-Np from the secreting cell	PE1	15
+NX_A7MCY6	TANK-binding kinase 1-binding protein 1	615	67702	5.62	0	Nucleoplasm	NA	Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.	NA	NA	RIG-I-like receptor signaling pathway	PE1	17
+NX_A7MD48	Serine/arginine repetitive matrix protein 4	611	68559	11.75	0	Nucleus	NA	Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:30684677). Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity).	Phosphorylated.	Belongs to the nSR100 family.	NA	PE1	12
+NX_A7XYQ1	Sine oculis-binding protein homolog	873	92658	7.77	0	Nucleoplasm;Cytoplasmic vesicle	Mental retardation, anterior maxillary protrusion, and strabismus	Implicated in development of the cochlea.	NA	Belongs to the SOBP family.	NA	PE1	6
+NX_A8CG34	Nuclear envelope pore membrane protein POM 121C	1229	125092	10.38	1	Endoplasmic reticulum membrane;Nucleus membrane;Nuclear pore complex	NA	Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).	NA	Belongs to the POM121 family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	7
+NX_A8K010	Putative transcriptional regulator encoded by LINC00473	186	21118	10.18	0	NA	NA	May play a role in cAMP-mediated gene transcription.	NA	NA	NA	PE5	6
+NX_A8K0R7	Zinc finger protein 839	811	87484	6.11	0	Cytoplasm;Nucleoplasm;Cell membrane	NA	NA	NA	NA	Generic Transcription Pathway	PE1	14
+NX_A8K0S8	Putative homeobox protein Meis3-like 2	358	39220	4.89	0	Nucleus	NA	NA	NA	Belongs to the TALE/MEIS homeobox family.	NA	PE2	17
+NX_A8K0Z3	WASH complex subunit 1	465	50328	5.49	0	Centriole;Autophagosome;Recycling endosome membrane;Late endosome;Early endosome membrane	NA	Acts as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting (PubMed:20498093). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity).	Ubiquitinated at Lys-220 via 'Lys-63'-linked ubiquitin chains by the TRIM27:MAGEL2 E3 ubiquitin ligase complex, leading to promote endosomal F-actin assembly.	Belongs to the WASH1 family.	NA	PE1	9
+NX_A8K2U0	Alpha-2-macroglobulin-like protein 1	1454	161107	5.5	0	Secreted	Otitis media	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.	NA	Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.	NA	PE1	12
+NX_A8K4G0	CMRF35-like molecule 7	201	22689	6.83	1	Cell membrane	NA	Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.	Phosphorylation on Tyr-188 by FYN is required for interaction with GRB2.	Belongs to the CD300 family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 interactions	PE1	17
+NX_A8K554	Putative protein ZNF815	130	15437	6.04	0	NA	NA	NA	NA	NA	NA	PE5	7
+NX_A8K5M9	Uncharacterized protein C15orf62, mitochondrial	175	19679	8.66	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	15
+NX_A8K7I4	Calcium-activated chloride channel regulator 1	914	100226	5.97	0	Extracellular space;Cell membrane	NA	May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.	Glycosylated.;The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.	Belongs to the CLCR family.	Olfactory transduction;Pancreatic secretion;Stimuli-sensing channels	PE1	1
+NX_A8K830	Colorectal cancer-associated protein 2	154	16850	4.27	0	Cytoplasm	NA	NA	NA	NA	NA	PE2	11
+NX_A8K855	EF-hand calcium-binding domain-containing protein 7	629	71981	6.01	0	Cell membrane;Nucleolus;Nucleoplasm;Cilium membrane;Cytosol	NA	Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia.	NA	NA	Activation of SMO	PE1	1
+NX_A8K8P3	Protein SFI1 homolog	1242	147664	10.82	0	Centriole	NA	Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.	NA	Belongs to the SFI1 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	22
+NX_A8K8V0	Zinc finger protein 785	405	46168	9.28	0	Nucleoplasm;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_A8K979	ERI1 exoribonuclease 2	691	77401	9.12	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	Belongs to the ERI2 family.	NA	PE1	16
+NX_A8MPP1	Putative ATP-dependent RNA helicase DDX11-like protein 8	907	101811	7.28	0	Nucleolus	NA	Putative DNA helicase.	NA	Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.	NA	PE1	12
+NX_A8MPS7	Carbohydrate deacetylase	323	34466	5.96	0	Nucleoplasm	NA	Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.	NA	Belongs to the YdjC deacetylase family.	NA	PE1	22
+NX_A8MPX8	Protein phosphatase 2C-like domain-containing protein 1	630	71643	8.93	0	Nucleoplasm;Cytoskeleton	NA	NA	NA	Belongs to the PP2C family.	NA	PE1	3
+NX_A8MPY1	Gamma-aminobutyric acid receptor subunit rho-3	467	54272	8.33	4	Postsynaptic cell membrane;Cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR3 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;GABA receptor activation	PE2	3
+NX_A8MQ03	Cysteine-rich tail protein 1	144	15313	6.67	0	Endoplasmic reticulum;Cytoplasmic vesicle;Nucleus speckle;Midbody	NA	NA	NA	Belongs to the CYSRT1 family.	NA	PE1	9
+NX_A8MQ11	Postmeiotic segregation increased 2-like protein 5	134	15170	10.61	0	NA	NA	NA	NA	Belongs to the DNA mismatch repair MutL/HexB family.	NA	PE5	7
+NX_A8MQ14	Zinc finger protein 850	1090	125431	9.02	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_A8MQ27	E3 ubiquitin-protein ligase NEURL1B	555	59270	8.76	0	Cytoplasm;Cytoplasmic vesicle	NA	E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.	NA	NA	Protein modification; protein ubiquitination.;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus	PE1	5
+NX_A8MQB3	Putative uncharacterized protein LINC02693	221	24325	9.82	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE5	17
+NX_A8MQT2	Golgin subfamily A member 8B	603	67278	6.46	0	Golgi stack membrane	NA	May be involved in maintaining Golgi structure.	NA	Belongs to the GOLGA8 family.	NA	PE2	15
+NX_A8MRT5	Nuclear pore complex-interacting protein family member B5	1133	126459	10.12	1	Membrane	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_A8MSI8	LYR motif-containing protein 9	78	9374	9.69	0	NA	NA	NA	NA	Belongs to the complex I LYR family. LYRM9 subfamily.	NA	PE1	17
+NX_A8MT19	Putative rhophilin-2-like protein RHPN2P1	583	65945	6.51	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_A8MT33	Synaptonemal complex central element protein 1-like	242	27397	4.99	0	Cytoskeleton	NA	May be involved in meiosis.	NA	Belongs to the SYCE family.	NA	PE1	16
+NX_A8MT65	Zinc finger protein 891	544	63592	9.01	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	12
+NX_A8MT66	Putative uncharacterized protein ENSP00000383407	165	19292	6.16	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_A8MT69	Centromere protein X	81	8959	5.59	0	Kinetochore;Centromere;Nucleus	NA	DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:20347429). DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347429).	NA	Belongs to the CENP-X/MHF2 family.	Fanconi anemia pathway;Deposition of new CENPA-containing nucleosomes at the centromere;Fanconi Anemia Pathway	PE1	17
+NX_A8MT70	Zinc finger B-box domain-containing protein 1	800	91426	5.43	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_A8MTA8	Protein FAM166B	275	30575	8.38	0	NA	NA	NA	NA	Belongs to the UPF0605 family.	NA	PE1	9
+NX_A8MTB9	Carcinoembryonic antigen-related cell adhesion molecule 18	384	43320	5.94	0	Midbody	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	NA	PE2	19
+NX_A8MTI9	Putative serine protease 47	375	41188	9	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE5	9
+NX_A8MTJ3	Guanine nucleotide-binding protein G(t) subunit alpha-3	354	40357	5.69	0	Cytoplasm	NA	Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.	Potential N-myristoylation may anchor alpha-subunit to the inner surface of plasma membrane.	Belongs to the G-alpha family. G(i/o/t/z) subfamily.	Taste transduction;Phototransduction;Carbohydrate digestion and absorption;G alpha (i) signalling events;G alpha (s) signalling events;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);G-protein activation;ADP signalling through P2Y purinoceptor 12;G alpha (z) signalling events;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling	PE1	7
+NX_A8MTJ6	Forkhead box protein I3	420	43326	8.51	0	Nucleus	NA	Possible transcriptional factor.	NA	NA	NA	PE1	2
+NX_A8MTL0	IQ domain-containing protein F5	148	18048	10.05	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_A8MTL3	RING finger protein 212B	300	33570	9.78	0	NA	NA	NA	NA	NA	NA	PE1	14
+NX_A8MTL9	Serpin-like protein HMSD	139	15355	5.27	0	Secreted	NA	Putative serine protease inhibitor.	NA	Belongs to the serpin family.	NA	PE2	18
+NX_A8MTQ0	Homeobox protein notochord	251	27003	9.43	0	Nucleus	NA	Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (By similarity).	NA	NA	NA	PE2	2
+NX_A8MTT3	Protein CEBPZOS	80	9336	9.7	1	Mitochondrion membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	2
+NX_A8MTW9	Putative uncharacterized protein ENSP00000380674	85	8750	10.5	0	Secreted	NA	NA	NA	NA	NA	PE5	2
+NX_A8MTY0	Zinc finger protein 724	619	71172	9.29	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_A8MTY7	Keratin-associated protein 9-7	169	17793	8.01	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the KRTAP type 9 family.	Keratinization	PE1	17
+NX_A8MTZ0	BBSome-interacting protein 1	92	10506	9.42	0	Cytoplasm;Cilium	Bardet-Biedl syndrome 18	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for primary cilia assembly and BBSome stability. Regulates cytoplasmic microtubule stability and acetylation.	NA	Belongs to the BBIP10 family.	BBSome-mediated cargo-targeting to cilium	PE1	10
+NX_A8MTZ7	Uncharacterized protein C12orf71	269	30355	5.21	0	NA	NA	NA	NA	NA	NA	PE1	12
+NX_A8MU10	Putative uncharacterized protein ENSP00000381562	97	10262	9.79	0	NA	NA	NA	NA	NA	NA	PE4	17
+NX_A8MU46	Smoothelin-like protein 1	494	52987	4.67	0	I band;Nucleus;M line;Myofibril	NA	Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity).	Maximal phosphorylation of Ser-336 correlates with maximal relaxation of aorta in response to acetylcholine.	Belongs to the smoothelin family.	NA	PE1	11
+NX_A8MU76	Putative UPF0607 protein ENSP00000381418	341	37608	10.73	0	NA	NA	NA	NA	Belongs to the UPF0607 family.	NA	PE2	16
+NX_A8MU93	Uncharacterized protein C17orf100	118	13000	11.57	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	NA	NA	NA	NA	PE1	17
+NX_A8MUA0	Putative UPF0607 protein ENSP00000381514	341	37841	10.75	0	NA	NA	NA	NA	Belongs to the UPF0607 family.	NA	PE3	2
+NX_A8MUH7	Putative PDZ domain-containing protein PDZK1P1	402	44056	5.4	0	NA	NA	NA	NA	Belongs to the NHER family.	NA	PE5	1
+NX_A8MUI8	Putative UPF0607 protein ENSP00000383783	341	37626	9.9	0	NA	NA	NA	NA	Belongs to the UPF0607 family.	NA	PE3	1
+NX_A8MUK1	Ubiquitin carboxyl-terminal hydrolase 17-like protein 5	530	59683	8.35	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	4
+NX_A8MUL3	Putative uncharacterized protein ADARB2-AS1	147	15836	7.71	0	NA	NA	NA	NA	NA	NA	PE5	10
+NX_A8MUM7	Galectin-16	142	16576	5.53	0	NA	NA	Binds lactose with high affinity. Strong inducer of T-cell apoptosis.	NA	NA	NA	PE2	19
+NX_A8MUN3	Putative uncharacterized protein ENSP00000381830	132	14205	9.1	0	Secreted	NA	NA	NA	NA	NA	PE5	17
+NX_A8MUP2	Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial	240	25910	5.51	0	Mitochondrion	NA	Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria (PubMed:28391595, PubMed:28887308). Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methly group per binding event (PubMed:28887308).	NA	Belongs to the methyltransferase superfamily.	NA	PE1	11
+NX_A8MUP6	Germ cell-specific gene 1-like protein 2	293	32443	6.3	4	Membrane	NA	NA	NA	Belongs to the GSG1 family.	NA	PE2	17
+NX_A8MUU1	Putative fatty acid-binding protein 5-like protein 3	101	11299	7.66	0	NA	NA	High specificity for fatty acids.	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	NA	PE5	7
+NX_A8MUU9	Putative uncharacterized protein ENSP00000383309	505	55306	13.3	0	NA	NA	NA	NA	NA	NA	PE5	22
+NX_A8MUV8	Putative zinc finger protein 727	499	57972	9.3	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE5	7
+NX_A8MUX0	Keratin-associated protein 16-1	517	53912	5.37	0	NA	NA	NA	NA	Belongs to the KRTAP type 16 family.	Keratinization	PE1	17
+NX_A8MUZ8	Putative zinc finger protein 705G	300	34765	9.37	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	8
+NX_A8MV23	Serpin E3	424	46963	6.7	0	Secreted	NA	Probable serine protease inhibitor.	NA	Belongs to the serpin family.	NA	PE1	13
+NX_A8MV24	Uncharacterized protein C17orf98	154	17565	9.8	0	Nucleolus;Cytoskeleton	NA	NA	NA	NA	NA	PE1	17
+NX_A8MV57	Putative mucosal pentraxin homolog	137	15138	5.89	0	NA	NA	NA	NA	Belongs to the pentraxin family.	NA	PE5	1
+NX_A8MV65	Transcription cofactor vestigial-like protein 3	326	36009	5.9	0	Nucleus;Cytosol;Nucleolus	NA	May act as a specific coactivator for the mammalian TEFs.	NA	Belongs to the vestigial family.	NA	PE1	3
+NX_A8MV72	Putative UPF0607 protein ENSP00000382826	311	34164	10.58	0	NA	NA	NA	NA	Belongs to the UPF0607 family.	NA	PE5	8
+NX_A8MV81	HIG1 domain family member 1C	97	11079	9.72	2	Membrane	NA	NA	NA	NA	NA	PE2	12
+NX_A8MVA2	Keratin-associated protein 9-6	160	16800	7.95	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the KRTAP type 9 family.	Keratinization	PE1	17
+NX_A8MVJ9	Putative histone PARylation factor 1-like	347	39722	8.28	0	NA	NA	NA	NA	Belongs to the HPF1 family.	NA	PE5	9
+NX_A8MVM7	Putative uncharacterized protein ENSP00000382790	634	73452	9.81	0	NA	NA	NA	NA	NA	NA	PE5	4
+NX_A8MVS1	Zinc finger protein 705F	300	34857	9.31	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE3	8
+NX_A8MVS5	Protein HIDE1	230	24753	6.82	1	Membrane;Golgi apparatus;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	19
+NX_A8MVU1	Putative neutrophil cytosol factor 1C	366	41851	8.95	0	Cytoplasm	NA	May be required for activation of the latent NADPH oxidase (necessary for superoxide production).	NA	NA	NA	PE5	7
+NX_A8MVW0	Protein FAM171A2	826	87435	8.14	1	Membrane	NA	NA	NA	Belongs to the FAM171 family.	NA	PE1	17
+NX_A8MVW5	HEPACAM family member 2	462	51407	6.09	1	Nucleoplasm;Centrosome;Golgi apparatus membrane;Cytoplasmic vesicle;Spindle;Midbody	NA	Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation.	Poly-ADP-ribosylated (PARsylated) by tankyrase TNKS during late G2 and prophase, leading to translocation to mitotic centrosomes.;N-glycosylated.	NA	NA	PE1	7
+NX_A8MVX0	Rho guanine nucleotide exchange factor 33	844	94633	6.37	0	Cytoplasmic vesicle	NA	May act as a guanine-nucleotide releasing factor.	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	2
+NX_A8MVZ5	Butyrophilin-like protein 10	291	32612	8.7	1	Membrane	NA	NA	NA	Belongs to the immunoglobulin superfamily. BTN/MOG family.	NA	PE5	1
+NX_A8MW92	PHD finger protein 20-like protein 1	1017	115010	6.39	0	Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	8
+NX_A8MW95	Beclin-2	431	48153	4.78	0	Cytoplasm	NA	Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.	NA	Belongs to the beclin family.	NA	PE1	1
+NX_A8MW99	Meiosis-specific protein MEI4	385	44024	5.82	0	Chromosome	NA	Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.	NA	Belongs to the MEI4L family.	NA	PE2	6
+NX_A8MWA4	Putative zinc finger protein 705E	300	34697	9.01	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	11
+NX_A8MWA6	Putative protein FAM90A22P	464	49874	9.86	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_A8MWD9	Putative small nuclear ribonucleoprotein G-like protein 15	76	8544	8.93	0	Nucleus	NA	Associated with snRNP U1, U2, U4/U6 and U5.	NA	Belongs to the snRNP Sm proteins family.	NA	PE5	19
+NX_A8MWE9	EF-hand calcium-binding domain-containing protein 8	144	16428	5.04	0	NA	NA	NA	NA	NA	NA	PE2	20
+NX_A8MWK0	Putative fatty acid desaturase 2-like protein FADS2P1	482	56358	8.02	4	Endoplasmic reticulum membrane	NA	NA	NA	Belongs to the fatty acid desaturase type 1 family.	Lipid metabolism; polyunsaturated fatty acid biosynthesis.	PE5	11
+NX_A8MWL6	Putative synaptogyrin-2 like protein	223	24647	4.38	4	Membrane	NA	NA	NA	Belongs to the synaptogyrin family.	NA	PE5	15
+NX_A8MWL7	Transmembrane protein 14DP	114	12177	9.57	4	Membrane	NA	NA	NA	Belongs to the TMEM14 family.	NA	PE5	10
+NX_A8MWP4	Putative uncharacterized protein ENSP00000401716	228	24535	9.77	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_A8MWP6	Uncharacterized protein ENSP00000382042	167	18109	5.64	0	NA	NA	NA	NA	NA	NA	PE2	17
+NX_A8MWV9	Small integral membrane protein 34A	139	15007	8.6	1	Membrane	NA	NA	NA	NA	NA	PE2	21
+NX_A8MWX3	Putative WAS protein family homolog 4	477	51595	6.24	0	Early endosome membrane;Recycling endosome membrane	NA	May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.	NA	Belongs to the WASH1 family.	NA	PE5	16
+NX_A8MWY0	UPF0577 protein KIAA1324-like	1029	113842	5.75	1	Membrane;Endoplasmic reticulum	NA	NA	NA	Belongs to the UPF0577 family.	NA	PE1	7
+NX_A8MX19	Putative protein FAM90A12P	464	49786	9.98	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_A8MX34	Keratin-associated protein 29-1	341	35211	5.89	0	NA	NA	NA	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE2	17
+NX_A8MX76	Calpain-14	684	79568	8.86	0	NA	NA	Calcium-regulated non-lysosomal thiol-protease.	NA	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	2
+NX_A8MX80	Putative UPF0607 protein ENSP00000383144	341	37634	10.46	0	NA	NA	NA	NA	Belongs to the UPF0607 family.	NA	PE3	13
+NX_A8MXD5	Glutaredoxin domain-containing cysteine-rich protein 1	290	32294	7.48	0	Stereocilium;Microvillus;Kinocilium	Deafness, autosomal recessive, 25	May play a role in actin filament architecture in developing stereocilia of sensory cells.	NA	Belongs to the GRXCR1 family.	NA	PE1	4
+NX_A8MXE2	Putative UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase LOC100288842	369	42761	7.08	1	Golgi apparatus membrane	NA	Putative glycosyltransferase.	NA	Belongs to the glycosyltransferase 2 family.	NA	PE5	9
+NX_A8MXJ8	Putative protein FAM90A5P	464	49840	9.86	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_A8MXK1	V-set and transmembrane domain-containing protein 5	200	22377	8.15	1	Endoplasmic reticulum;Axon;Dendrite;Cell membrane	NA	Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain.	N-glycosylated.	NA	NA	PE2	11
+NX_A8MXK9	Uncharacterized protein ENSP00000382033	166	18008	6.09	0	NA	NA	NA	NA	NA	NA	PE2	17
+NX_A8MXQ7	Putative IQ motif and ankyrin repeat domain-containing protein LOC642574	604	68295	6.18	0	NA	NA	NA	NA	NA	NA	PE5	8
+NX_A8MXT2	Melanoma-associated antigen B17	336	37578	9.25	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	X
+NX_A8MXU0	Putative beta-defensin 108A	73	8390	8.9	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins	PE5	8
+NX_A8MXV4	Nucleoside diphosphate-linked moiety X motif 19	375	42233	7.28	0	Nucleoplasm;Peroxisome;Cytosol;Nucleolus	NA	Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).	NA	Belongs to the Nudix hydrolase family.	Peroxisome;Peroxisomal lipid metabolism;Peroxisomal protein import	PE1	19
+NX_A8MXV6	CMT1A duplicated region transcript 15 protein-like protein	281	30100	9.53	1	Membrane	NA	NA	NA	NA	NA	PE2	17
+NX_A8MXY4	Zinc finger protein 99	864	100791	9.54	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_A8MXZ1	Putative protein FAM90A23P	464	49910	9.98	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_A8MXZ3	Keratin-associated protein 9-1	250	26333	8.05	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the KRTAP type 9 family.	Keratinization	PE1	17
+NX_A8MY62	Putative beta-lactamase-like 1	500	54653	8.75	0	NA	NA	NA	NA	Belongs to the beta-lactamase family.	NA	PE1	1
+NX_A8MYA2	Uncharacterized protein CXorf49	514	54417	9.18	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_A8MYB1	Transmembrane and coiled-coil domain-containing protein 5B	307	35763	4.98	1	Membrane	NA	NA	NA	Belongs to the TMCO5 family.	NA	PE3	15
+NX_A8MYJ7	Tetratricopeptide repeat protein 34	566	60903	6.98	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_A8MYP8	Outer dense fiber protein 3B	253	27280	10.42	0	NA	NA	NA	NA	Belongs to the ODF3 family.	NA	PE1	22
+NX_A8MYU2	Potassium channel subfamily U member 1	1149	129543	8.08	7	Cell membrane	NA	Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.	NA	Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily.	Vascular smooth muscle contraction;Sperm Motility And Taxes	PE1	8
+NX_A8MYV0	Doublecortin domain-containing protein 2C	355	40425	9.46	0	Cytoplasm;Flagellum	NA	NA	NA	NA	NA	PE1	2
+NX_A8MYX2	Protein FAM25E	175	18345	6.23	0	NA	NA	NA	NA	Belongs to the FAM25 family.	NA	PE2	10
+NX_A8MYZ0	Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B	460	51976	6.25	0	NA	NA	NA	NA	Belongs to the MINDY deubiquitinase family. FAM188 subfamily.	NA	PE2	3
+NX_A8MYZ5	IQ domain-containing protein F6	107	13059	11.71	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_A8MYZ6	Forkhead box protein O6	492	50595	5.25	0	Cytoplasm;Nucleus	NA	Transcriptional activator.	Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.	NA	AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Regulation of localization of FOXO transcription factors	PE1	1
+NX_A8MZ25	Putative uncharacterized protein FLJ38767	164	18125	11.55	0	NA	NA	NA	NA	NA	NA	PE5	17
+NX_A8MZ26	EF-hand calcium-binding domain-containing protein 9	197	23937	8.95	0	Cytoplasm;Flagellum	NA	PH-dependent Ca(2+) sensor required to activate the CatSper channel, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.	NA	NA	NA	PE1	5
+NX_A8MZ36	Envoplakin-like protein	301	33953	5.8	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the plakin or cytolinker family.	NA	PE1	17
+NX_A8MZ59	Leucine-twenty homeobox	168	18626	5.68	0	Nucleoplasm;Nucleolus;Nucleus	NA	NA	NA	Belongs to the paired homeobox family.	NA	PE2	19
+NX_A8MZ97	Uncharacterized protein C2orf74	194	21915	6.01	1	Membrane;Centrosome	NA	NA	NA	NA	NA	PE1	2
+NX_A8MZA4	Golgin subfamily A member 6-like protein 6	724	90952	5.06	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE2	15
+NX_A8MZF0	Proline-rich protein 33	331	35187	8.54	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_A8MZG2	Uncharacterized protein C16orf90	182	19564	8.54	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_A8MZH6	Putative oocyte-secreted protein 1 homolog	123	14433	8.23	0	Secreted	NA	May be involved in cell differentiation.	NA	Belongs to the PLAC1 family.	NA	PE5	11
+NX_A8TX70	Collagen alpha-5(VI) chain	2615	289926	6.5	0	Extracellular matrix	NA	Collagen VI acts as a cell-binding protein.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the type VI collagen family.	Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	3
+NX_A9QM74	Importin subunit alpha-8	516	56938	5.73	0	Nucleus	NA	Functions in nuclear protein import.	NA	Belongs to the importin alpha family.	ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways	PE1	7
+NX_A9UHW6	MIF4G domain-containing protein	222	25423	5.23	0	Golgi apparatus;Cytoplasm;Nucleolus;Cytosol;Nucleus	NA	Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.	NA	Belongs to the MIF4GD family.	NA	PE1	17
+NX_A9YTQ3	Aryl hydrocarbon receptor repressor	701	76265	9.14	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.	NA	NA	Xenobiotics;PPARA activates gene expression;Endogenous sterols;Phase I - Functionalization of compounds;Aryl hydrocarbon receptor signalling	PE1	5
+NX_A9Z1Z3	Fer-1-like protein 4	1794	200980	5.88	1	Membrane	NA	NA	NA	Belongs to the ferlin family.	NA	PE2	20
+NX_B0FP48	Uroplakin-3b-like protein 1	263	28385	8.4	1	Membrane	NA	NA	NA	Belongs to the uroplakin-3 family.	NA	PE1	7
+NX_B0I1T2	Unconventional myosin-Ig	1018	116442	8.96	0	Phagocytic cup;Cell membrane	NA	Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.;Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	7
+NX_B0YJ81	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1	288	32388	9.1	6	Endoplasmic reticulum membrane	Myopathy, congenital, with fiber-type disproportion	In tooth development, may play a role in the recruitment and the differentiation of cells that contribute to cementum formation. May also bind hydroxyapatite and regulate its crystal nucleation to form cementum.;Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.	N-glycosylated.	Belongs to the very long-chain fatty acids dehydratase HACD family.	Lipid metabolism; fatty acid biosynthesis.;Fatty acid elongation;Biosynthesis of unsaturated fatty acids;Synthesis of very long-chain fatty acyl-CoAs	PE1	10
+NX_B1AH88	Putative peripheral benzodiazepine receptor-related protein	102	10537	8.81	0	NA	NA	NA	NA	NA	Neuroactive ligand-receptor interaction;HTLV-I infection	PE5	22
+NX_B1AJZ1	Putative uncharacterized protein C1orf196	125	14253	7.82	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_B1AJZ9	Forkhead-associated domain-containing protein 1	1412	161904	6.52	0	Nucleus	NA	NA	NA	NA	NA	PE1	1
+NX_B1AK53	Espin	854	91733	6.47	0	Stereocilium;Cytoplasmic vesicle;Microvillus;Cytoskeleton	Deafness, autosomal recessive, 36, with or without vestibular involvement	Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation.	NA	NA	NA	PE1	1
+NX_B1AK76	Putative SNURF-like protein	121	14245	8.82	0	NA	NA	NA	NA	Belongs to the SNURF family.	NA	PE5	X
+NX_B1AKI9	Isthmin-1	464	52107	5.22	0	Secreted	NA	Acts as an angiogenesis inhibitor.	NA	Belongs to the isthmin family.	NA	PE1	20
+NX_B1AL46	NUT family member 2E	878	93979	7.97	0	NA	NA	NA	NA	Belongs to the NUT family.	NA	PE2	10
+NX_B1AL88	Transmembrane protein FAM155A	458	51493	6.2	2	Membrane;Cytoplasmic vesicle;Nucleoplasm;Centrosome	NA	NA	NA	Belongs to the FAM155 family.	NA	PE1	13
+NX_B1AMM8	Putative uncharacterized protein encoded by LINC00587	73	8554	6.39	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_B1ANH7	Putative uncharacterized protein IBA57-DT	110	12198	9.26	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_B1ANS9	WD repeat-containing protein 64	1081	123631	8.47	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_B1ANY3	Putative protein FAM220BP	271	29405	8.89	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_B1APH4	Putative zinc finger protein 487	448	51624	8.07	0	Nucleoplasm;Cytosol;Nucleus membrane;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE5	10
+NX_B1ATL7	Proline-rich protein 32	298	31890	7.26	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_B2CW77	Killin	178	19958	11.27	0	Nucleoplasm;Nucleus;Nucleolus	Cowden syndrome 4	DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA.	NA	NA	NA	PE1	10
+NX_B2RBV5	Putative MORF4 family-associated protein 1-like protein UPP	119	13369	8.49	0	NA	NA	May play a role in cell proliferation.	NA	Belongs to the MORF4 family-associated protein family.	NA	PE1	4
+NX_B2RC85	Radial spoke head 10 homolog B2	870	100547	7.16	0	NA	NA	NA	NA	NA	NA	PE1	7
+NX_B2RD01	CENPB DNA-binding domain-containing protein 1	187	21052	6.54	0	Cytoplasmic vesicle;Nucleolus;Nucleus	NA	NA	NA	NA	NA	PE2	16
+NX_B2RN74	Olfactory receptor 11H12	326	36530	8.14	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	14
+NX_B2RNN3	Complement C1q and tumor necrosis factor-related protein 9B	333	34713	8.23	0	Secreted	NA	Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.	NA	NA	NA	PE1	13
+NX_B2RPK0	Putative high mobility group protein B1-like 1	211	24238	5.92	0	Nucleus;Chromosome	NA	Binds preferentially single-stranded DNA and unwinds double-stranded DNA.	NA	Belongs to the HMGB family.	NA	PE5	20
+NX_B2RTY4	Unconventional myosin-IXa	2548	292706	9.03	1	Cytoplasm;Cell membrane;Growth cone;Membrane;Synapse	Myasthenic syndrome, congenital, 24, presynaptic	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity).	Phosphorylated by ALPK1 following monosodium urate monohydrate (MSU)-induced inflammation.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Rho GTPase cycle	PE1	15
+NX_B2RU33	POTE ankyrin domain family member C	542	61188	6.31	0	NA	NA	NA	NA	Belongs to the POTE family.	NA	PE1	18
+NX_B2RUY7	von Willebrand factor C domain-containing protein 2-like	222	24570	5.06	0	Secreted;Synapse	NA	May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.	NA	NA	NA	PE1	2
+NX_B2RUZ4	Small integral membrane protein 1	78	8749	9.22	1	Cell membrane	NA	Regulator of red blood cell formation.	NA	Belongs to the SMIM1 family.	NA	PE1	1
+NX_B2RV13	Uncharacterized protein CFAP97D1	164	19546	10.07	0	NA	NA	NA	NA	Belongs to the CFAP97 family.	NA	PE1	17
+NX_B2RXF0	Transmembrane protein 229A	380	42370	9.95	6	Membrane;Cell membrane	NA	NA	NA	Belongs to the TMEM229 family.	NA	PE1	7
+NX_B2RXF5	Zinc finger and BTB domain-containing protein 42	422	46491	8.85	0	Nucleoplasm;Cytoplasm;Nucleus	Lethal congenital contracture syndrome 6	Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.	NA	PE1	14
+NX_B2RXH2	Lysine-specific demethylase 4E	506	56804	7.95	0	Nucleus	NA	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.	NA	Belongs to the JHDM3 histone demethylase family.	NA	PE1	11
+NX_B2RXH4	BTB/POZ domain-containing protein 18	712	77931	4.94	0	Nucleus	NA	Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene.	NA	NA	NA	PE2	11
+NX_B2RXH8	Heterogeneous nuclear ribonucleoprotein C-like 2	293	32072	5.29	0	Nucleus	NA	May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.	NA	Belongs to the RRM HNRPC family. RALY subfamily.	NA	PE1	1
+NX_B3EWF7	Laforin, isoform 9	344	35169	11.93	0	Nucleus	NA	NA	NA	NA	NA	PE1	6
+NX_B3EWG3	Protein FAM25A	89	9320	5.78	0	NA	NA	NA	NA	Belongs to the FAM25 family.	NA	PE1	10
+NX_B3EWG5	Protein FAM25C	89	9320	5.78	0	NA	NA	NA	NA	Belongs to the FAM25 family.	NA	PE1	10
+NX_B3EWG6	Protein FAM25G	89	9320	5.78	0	NA	NA	NA	NA	Belongs to the FAM25 family.	NA	PE1	10
+NX_B3GLJ2	Prostate and testis expressed protein 3	98	11747	9.3	0	Secreted	NA	NA	NA	Belongs to the PATE family.	NA	PE1	11
+NX_B3KS81	Serine/arginine repetitive matrix protein 5	715	80355	12.05	0	NA	NA	NA	NA	NA	NA	PE1	19
+NX_B3KU38	IQCJ-SCHIP1 readthrough transcript protein	563	62248	5.08	0	Cytoplasm;Axon	NA	May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943). May also play a role in axon outgrowth and guidance (By similarity).	NA	NA	NA	PE1	3
+NX_B3SHH9	Transmembrane protein 114	223	24166	5.9	4	Cell membrane	NA	NA	NA	Belongs to the PMP-22/EMP/MP20 family.	NA	PE2	16
+NX_B4DH59	Neuroblastoma breakpoint family member 26	902	103816	4.35	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE5	1
+NX_B4DJY2	Transmembrane protein 233	109	12074	4.93	2	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the CD225/Dispanin family.	NA	PE1	12
+NX_B4DS77	Protein shisa-9	424	46925	8.95	1	Dendritic spine membrane;Synapse	NA	Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).	NA	Belongs to the shisa family. SHISA9 subfamily.	NA	PE1	16
+NX_B4DU55	Zinc finger protein 879	563	64577	9.63	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	5
+NX_B4DX44	Zinc finger protein 736	427	49868	9.1	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_B4DXR9	Zinc finger protein 732	585	67839	9.19	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	4
+NX_B4DYI2	Putative spermatogenesis-associated protein 31C2	1134	124429	9.42	1	Membrane	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA31 family.	NA	PE5	9
+NX_B4DZS4	T-complex protein 11 X-linked protein 1	312	34563	4.6	0	NA	NA	NA	NA	Belongs to the TCP11 family.	NA	PE2	X
+NX_B4E2M5	Ankyrin repeat domain-containing protein 66	251	27916	9.3	0	NA	NA	NA	NA	NA	NA	PE1	6
+NX_B5MCN3	Putative SEC14-like protein 6	397	45364	6.63	0	Nucleoplasm	NA	NA	NA	NA	NA	PE5	22
+NX_B5MCY1	Tudor domain-containing protein 15	1934	221722	6.67	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_B5MD39	Putative glutathione hydrolase light chain 3	225	24102	5.75	0	NA	NA	NA	NA	Belongs to the gamma-glutamyltransferase family.	NA	PE5	22
+NX_B5ME19	Eukaryotic translation initiation factor 3 subunit C-like protein	914	105473	5.45	0	Cytoplasm	NA	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.	Phosphorylated. Phosphorylation is enhanced upon serum stimulation (By similarity).	Belongs to the eIF-3 subunit C family.	NA	PE1	16
+NX_B6A8C7	T-cell-interacting, activating receptor on myeloid cells protein 1	271	29474	8.87	1	Cell membrane	NA	May act as receptor (By similarity). Negatively regulates TCR-mediated CD4(+) T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface (PubMed:26311901). Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils (By similarity).	N-glycosylated.	NA	Neutrophil degranulation	PE1	19
+NX_B6SEH8	Endogenous retrovirus group V member 1 Env polyprotein	477	52557	8.76	1	Membrane	NA	NA	NA	Belongs to the gamma type-C retroviral envelope protein family.	NA	PE2	19
+NX_B6SEH9	Endogenous retrovirus group V member 2 Env polyprotein	535	59317	8.87	2	Membrane	NA	NA	NA	Belongs to the gamma type-C retroviral envelope protein family.	NA	PE1	19
+NX_B7U540	Inward rectifier potassium channel 18	433	48880	5.76	2	Cell membrane	Thyrotoxic periodic paralysis 2	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.	Probably phosphorylated by PKC; decreases single-channel open probability.	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.	NA	PE1	17
+NX_B7Z1M9	C2 calcium-dependent domain-containing protein 4D	353	37583	11.24	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_B7Z368	Uncharacterized protein C10orf142	130	13757	9.83	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_B7Z6K7	Zinc finger protein 814	855	97337	9.14	0	NA	NA	NA	NA	NA	NA	PE1	19
+NX_B7Z8K6	T cell receptor delta constant	153	17085	9.42	1	Cell membrane	NA	Constant region of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	14
+NX_B7ZAP0	Rab GTPase-activating protein 1-like, isoform 10	253	29038	5.28	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_B7ZAQ6	Golgi pH regulator A	455	52917	9.34	9	Endoplasmic reticulum;Golgi apparatus membrane	NA	Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.	NA	Belongs to the Golgi pH regulator (TC 1.A.38) family.	NA	PE1	1
+NX_B7ZBB8	Protein phosphatase 1 regulatory subunit 3G	358	38019	4.88	0	NA	NA	Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity).	NA	NA	NA	PE1	6
+NX_B7ZC32	Kinesin-like protein KIF28P	967	108254	8.68	0	Mitochondrion membrane	NA	Microtubule-dependent motor protein required for mitochondrion morhology and transport of mitochondria in neuronal cells.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE3	1
+NX_B7ZW38	Heterogeneous nuclear ribonucleoprotein C-like 3	293	32029	5.48	0	Nucleus	NA	NA	NA	Belongs to the RRM HNRPC family. RALY subfamily.	NA	PE1	1
+NX_B8ZZ34	Protein shisa-8	397	41995	10.56	1	Membrane	NA	May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses.	NA	Belongs to the shisa family.	NA	PE1	22
+NX_B9A014	Protein FAM243A	251	29214	8.7	0	NA	NA	NA	NA	Belongs to the FAM243 family.	NA	PE2	21
+NX_B9A064	Immunoglobulin lambda-like polypeptide 5	214	23063	9.08	0	Secreted	NA	NA	NA	NA	NA	PE1	22
+NX_B9A6J9	TBC1 domain family member 3L	549	62187	9.2	0	Cell membrane	NA	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).	Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.;Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.	NA	NA	PE2	17
+NX_B9EJG8	Transmembrane protein 150C	249	27887	6.08	6	Lysosome membrane;Cell membrane	NA	Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception.	NA	Belongs to the DRAM/TMEM150 family.	NA	PE1	4
+NX_B9ZVM9	T-complex protein 10A homolog 2	353	38357	7.18	0	NA	NA	NA	NA	Belongs to the TCP10 family.	NA	PE2	6
+NX_C4AMC7	Putative WAS protein family homolog 3	463	49995	5.36	0	Centriole;Early endosome;Lamellipodium;Autophagosome;Filopodium;Recycling endosome membrane;Early endosome membrane	NA	Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity).	NA	Belongs to the WASH1 family.	NA	PE1	15
+NX_C9J069	Apical junction component 1 homolog	976	106650	9.26	0	Adherens junction;Focal adhesion;Cilium;Cytosol;Apical cell membrane	NA	May be involved in the control of adherens junction integrity.	NA	NA	NA	PE1	9
+NX_C9J1S8	Tripartite motif-containing protein 49D	452	52496	8.74	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE1	11
+NX_C9J202	Putative glycosyltransferase ALG1L2	215	24154	5.47	0	NA	NA	Putative glycosyltransferase.	NA	Belongs to the glycosyltransferase group 1 family.	NA	PE2	3
+NX_C9J2P7	Ubiquitin carboxyl-terminal hydrolase 17-like protein 15	530	59676	8.22	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE2	4
+NX_C9J302	Uncharacterized protein C4orf51	202	23001	8.57	0	NA	NA	NA	NA	NA	NA	PE2	4
+NX_C9J3I9	Putative uncharacterized protein C5orf58	102	11666	6.84	0	NA	NA	NA	NA	NA	NA	PE1	5
+NX_C9J3V5	Testis-expressed protein 22	150	16880	10.33	0	Cytoplasm;Acrosome	NA	NA	NA	NA	NA	PE1	14
+NX_C9J442	Uncharacterized protein C22orf46	243	27532	8.94	0	Nucleoplasm;Secreted;Nucleolus	NA	NA	NA	NA	NA	PE5	22
+NX_C9J6K1	Putative uncharacterized protein C19orf81	198	22444	6.97	0	Cytoplasmic vesicle;Cytosol	NA	NA	NA	NA	NA	PE1	19
+NX_C9J798	Ras GTPase-activating protein 4B	803	90406	7.81	0	Cytosol;Cell membrane	NA	Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway.	NA	NA	NA	PE1	7
+NX_C9J7I0	UBAP1-MVB12-associated (UMA)-domain containing protein 1	137	15200	4.35	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	7
+NX_C9JBD0	KRAB domain-containing protein 1	128	14906	9.42	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	NA	NA	PE2	3
+NX_C9JC47	Putative protein FAM157A	383	42896	11.26	0	NA	NA	NA	NA	Belongs to the FAM157 family.	NA	PE3	3
+NX_C9JCN9	Heat shock factor-binding protein 1-like protein 1	74	8384	4.86	0	Nucleoplasm	NA	NA	NA	Belongs to the HSBP1 family.	NA	PE2	18
+NX_C9JDP6	Putative claudin-25	229	25394	5.37	4	Tight junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	NA	PE5	11
+NX_C9JDV5	Putative uncharacterized protein C12orf77	145	16178	9.67	0	NA	NA	NA	NA	NA	NA	PE2	12
+NX_C9JE40	Protein PAT1 homolog 2	543	61464	5	0	Cytoplasm;Nucleus	Oocyte maturation defect 4	RNA-binding protein that acts as a translational repressor.	NA	Belongs to the PAT1 family.	NA	PE1	15
+NX_C9JFL3	Proline, histidine and glycine-rich protein 1	82	7706	7.25	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	15
+NX_C9JG80	Nuclear pore complex-interacting protein family member B4	1138	126699	10.08	1	Membrane	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_C9JH25	Proline-rich transmembrane protein 4	899	92712	6.27	5	Membrane;Peroxisome;Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	7
+NX_C9JI98	Transmembrane protein 238	176	18040	11.54	2	Membrane	NA	NA	NA	NA	NA	PE1	19
+NX_C9JJ37	BTB/POZ domain-containing protein 19	291	32365	6.21	0	Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_C9JJH3	Ubiquitin carboxyl-terminal hydrolase 17-like protein 10	530	59886	8.46	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	4
+NX_C9JL84	HERV-H LTR-associating protein 1	531	58297	9.11	0	Secreted	NA	NA	NA	NA	NA	PE2	8
+NX_C9JLJ4	Ubiquitin carboxyl-terminal hydrolase 17-like protein 13	530	59694	8.22	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	4
+NX_C9JLR9	Uncharacterized protein C11orf95	678	73197	5.82	0	Cytoskeleton	NA	NA	NA	NA	NA	PE1	11
+NX_C9JLW8	Mapk-regulated corepressor-interacting protein 1	97	10920	9.39	0	Cytosol;Stress granule;Nucleus	NA	The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).	Phosphorylation by MAPK3/1 (ERK1/2) regulates MCRIP1 binding to CTBP(s) (PubMed:25728771).	Belongs to the MCRIP family.	NA	PE1	17
+NX_C9JN71	Zinc finger protein 878	531	61540	9.55	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_C9JPN9	Ubiquitin carboxyl-terminal hydrolase 17-like protein 12	530	59687	8.35	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	4
+NX_C9JQI7	Transmembrane protein 232	657	76453	8.29	2	Membrane	NA	NA	NA	NA	NA	PE2	5
+NX_C9JQL5	Putative dispanin subfamily A member 2d	133	14796	9.61	2	Membrane	NA	NA	NA	Belongs to the CD225/Dispanin family.	NA	PE5	12
+NX_C9JR72	Kelch repeat and BTB domain-containing protein 13	458	49485	5.47	0	Cytoplasm	Nemaline myopathy 6	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex.	Autoubiquitinated.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination & Proteasome degradation;Neddylation	PE1	15
+NX_C9JRZ8	Aldo-keto reductase family 1 member B15	316	36537	6.23	0	Cytosol;Mitochondrion	NA	Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439).;No oxidoreductase activity observed with the tested substrates.	NA	Belongs to the aldo/keto reductase family.	Estrogen biosynthesis	PE1	7
+NX_C9JSJ3	Basic helix-loop-helix and HMG box domain-containing protein 1	638	70198	9.1	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE2	19
+NX_C9JTQ0	Ankyrin repeat domain-containing protein 63	380	39620	11.04	0	NA	NA	NA	NA	NA	NA	PE1	15
+NX_C9JUS6	Putative adrenomedullin-5-like protein	153	16532	9.48	0	Secreted	NA	Probable non-functional remnant of adrenomedullin-5.	NA	Belongs to the adrenomedullin family.	NA	PE2	19
+NX_C9JVI0	Ubiquitin carboxyl-terminal hydrolase 17-like protein 11	530	59630	8.22	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE2	4
+NX_C9JVW0	Putative transmembrane protein INAFM1	142	14668	10.69	1	Membrane	NA	NA	NA	NA	NA	PE1	19
+NX_C9JXX5	Uncharacterized protein C11orf94	98	10902	9.97	0	Secreted	NA	NA	NA	NA	NA	PE2	11
+NX_D3DTV9	Putative protein PRAC2	90	10428	12	0	Nucleus	NA	NA	NA	NA	NA	PE5	17
+NX_D3W0D1	Killer cell lectin-like receptor subfamily F member 2	207	24008	5.83	1	Cell membrane	NA	C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.	N-glycosylated.	NA	NA	PE1	12
+NX_D6R901	Ubiquitin carboxyl-terminal hydrolase 17-like protein 21	530	59659	8.22	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	4
+NX_D6R9N7	Ubiquitin carboxyl-terminal hydrolase 17-like protein 18	530	59657	8.35	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	4
+NX_D6RA61	Ubiquitin carboxyl-terminal hydrolase 17-like protein 22	530	59671	8.35	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	4
+NX_D6RBM5	Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23	183	20302	7.13	0	Endoplasmic reticulum;Nucleus	NA	NA	NA	Belongs to the peptidase C19 family. USP17 subfamily.	NA	PE5	4
+NX_D6RBQ6	Ubiquitin carboxyl-terminal hydrolase 17-like protein 17	530	59627	8.22	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE2	4
+NX_D6RCP7	Ubiquitin carboxyl-terminal hydrolase 17-like protein 19	530	59658	8.35	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	4
+NX_D6REC4	Cilia- and flagella-associated protein 99	459	52293	10.55	0	Flagellum	NA	NA	NA	Belongs to the CFAP99 family.	NA	PE1	4
+NX_D6RF30	Golgin subfamily A member 8K	607	68878	8.64	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE2	15
+NX_D6RGH6	Multicilin	385	41720	5.62	0	Nucleus	NA	Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211).	NA	Belongs to the geminin family.	NA	PE1	5
+NX_D6RGX4	Putative protein FAM90A26	464	49883	9.82	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	4
+NX_D6RIA3	Uncharacterized protein C4orf54	1793	190074	9.11	0	NA	NA	NA	NA	NA	NA	PE1	4
+NX_D6RJB6	Ubiquitin carboxyl-terminal hydrolase 17-like protein 20	530	59626	8.22	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	4
+NX_E0CX11	Short transmembrane mitochondrial protein 1	47	5265	9.1	1	Mitochondrion membrane;Mitochondrion	NA	NA	NA	Belongs to the STMP1 family.	NA	PE1	7
+NX_E2RYF6	Mucin-22	1773	173478	3.9	1	Membrane	NA	NA	NA	NA	NA	PE1	6
+NX_E2RYF7	Protein PBMUCL2	251	26282	4.36	0	Secreted	NA	NA	NA	NA	NA	PE2	6
+NX_E5RG02	Putative serine protease 46	174	19341	9.32	0	NA	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE3	3
+NX_E5RHQ5	Nuclear pore complex-interacting protein family member B11	1161	129208	10.06	1	Membrane	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_E5RIL1	Uroplakin-3b-like protein 2	263	28385	8.4	1	Membrane	NA	NA	NA	Belongs to the uroplakin-3 family.	NA	PE1	7
+NX_E5RJ46	Uncharacterized protein C8orf87	101	11413	11.36	0	NA	NA	NA	NA	NA	NA	PE4	8
+NX_E5RJM6	Ankyrin repeat domain-containing protein 65	399	41497	6.09	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_E5RQL4	Formiminotransferase N-terminal subdomain-containing protein	147	16268	9.21	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the formiminotransferase family.	NA	PE2	2
+NX_E7ERA6	RING finger protein 223	249	26629	9.43	1	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_E7ETH6	Zinc finger protein 587B	402	45541	8.73	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_E7EU14	Protein PPP5D1	171	19623	9.4	0	Cytosol	NA	NA	NA	Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.	NA	PE1	19
+NX_E7EW31	Proline-rich basic protein 1	1015	106917	9.68	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	5
+NX_E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	2078	205422	9.6	0	Cytoplasm;Nucleus	NA	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity).	NA	NA	NA	PE1	12
+NX_E9PB15	Putative protein PTGES3L	166	19074	4.81	0	NA	NA	NA	NA	Belongs to the p23/wos2 family.	NA	PE5	17
+NX_E9PGG2	Anomalous homeobox protein	379	41695	5.25	0	Nucleus	NA	NA	NA	NA	NA	PE1	12
+NX_E9PI22	Proline-rich protein 23D1	279	31050	6.08	0	NA	NA	NA	NA	Belongs to the PRR23 family.	NA	PE2	8
+NX_E9PIF3	Nuclear pore complex-interacting protein family member A2	369	42223	9.62	0	NA	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_E9PJ23	Nuclear pore complex-interacting protein family member B6	425	49162	10.38	0	NA	NA	NA	NA	Belongs to the NPIP family.	NA	PE1	16
+NX_E9PJI5	Nuclear pore complex-interacting protein family member A7	369	42230	9.22	0	NA	NA	NA	NA	Belongs to the NPIP family.	NA	PE1	16
+NX_E9PKD4	Nuclear pore complex-interacting protein family member A5	350	40105	9.48	0	NA	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_E9PQ53	NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2	114	13408	8.47	1	Mitochondrion inner membrane	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).	NA	Belongs to the complex I NDUFC2 subunit family.	NA	PE1	11
+NX_E9PQR5	Nuclear pore complex-interacting protein family member B8	432	49617	10.15	0	NA	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_E9PQX1	Transmembrane protein 262	116	13758	6.11	3	Membrane	NA	NA	NA	NA	NA	PE2	11
+NX_E9PRG8	Uncharacterized protein C11orf98	123	14234	11.53	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_F2Z333	Fibronectin type III domain-containing protein 10	226	24218	9.11	1	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_F2Z398	LMO7 downstream neighbor protein	122	13273	5	0	NA	NA	NA	NA	NA	NA	PE2	13
+NX_F2Z3F1	Uncharacterized protein C5orf67	127	14123	9.23	0	NA	NA	NA	NA	NA	NA	PE2	5
+NX_F2Z3M2	Uncharacterized protein C17orf112	114	12668	5.7	0	NA	NA	NA	NA	NA	NA	PE4	17
+NX_F5GYI3	Ubiquitin-associated protein 1-like	381	40592	5.37	0	Nucleus	NA	NA	NA	NA	NA	PE2	15
+NX_F5H284	Peptidyl-prolyl cis-trans isomerase A-like 4D	164	18167	9.43	0	Cytoplasm	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).	NA	Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.	NA	PE2	1
+NX_F5H4A9	Uncharacterized membrane protein C3orf80	247	25682	5.51	1	Membrane	NA	NA	NA	NA	NA	PE1	3
+NX_F5H4B4	Protein FAM227A	570	66188	9.39	0	Nucleoplasm	NA	NA	NA	Belongs to the FAM227 family.	NA	PE1	22
+NX_F7VJQ1	Alternative prion protein	73	8691	9.24	1	Mitochondrion outer membrane	NA	NA	NA	NA	NA	PE1	20
+NX_F8VTS6	Ret finger protein-like 4A-like protein 1	287	32249	7.47	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_F8W1W9	Nuclear pore complex-interacting protein family member B9	429	49181	10.44	0	NA	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_F8WBI6	Golgin subfamily A member 8N	632	71524	5.93	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE2	15
+NX_F8WCM5	Insulin, isoform 2	200	21537	5.93	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_F8WFD2	Nuclear pore complex-interacting protein family member A3	350	40061	9.48	0	NA	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_G2XKQ0	Small ubiquitin-related modifier 5	101	11526	5.33	0	Nucleus	NA	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Regulates the life cycle of promyelocytic leukemia nuclear bodies (PML-NBs). PolySUMO1P1/SUMO5 conjugation on 'Lys-160' of PML facilitates recruitment of PML-NB components, which enlarges PML-NB. SUMO1P1/SUMO5 also increases polySUMO2/3 conjugation of PML, resulting in RNF4-mediated disruption of PML-NBs.	Autosumoylated at Lys-18.;Cleavage of precursor form is necessary for function.	Belongs to the ubiquitin family. SUMO subfamily.	NA	PE1	20
+NX_G3V0H7	Putative solute carrier organic anion transporter family member 1B7	640	71247	8.8	11	Cell membrane	NA	NA	NA	Belongs to the organo anion transporter (TC 2.A.60) family.	NA	PE5	12
+NX_G3V211	Uncharacterized protein encoded by LINC01619	115	13510	9.43	0	NA	NA	NA	NA	NA	NA	PE5	12
+NX_G9CGD6	CNK3/IPCEF1 fusion protein	899	100365	8.55	0	NA	NA	Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration.	NA	Belongs to the CNKSR family.	NA	PE1	6
+NX_H0UI37	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3	97	11268	5.43	0	NA	NA	NA	NA	NA	NA	PE2	6
+NX_H0Y354	Protein FAM72C	149	16730	6.27	0	NA	NA	NA	NA	Belongs to the FAM72 family.	NA	PE2	1
+NX_H0Y7S4	Putative PRAME family member 26	382	44302	8.65	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE5	1
+NX_H0YKK7	Putative golgin subfamily A member 6-like protein 19	550	64493	4.78	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE5	15
+NX_H0YL09	Putative ubiquitin-conjugating enzyme E2Q2-like protein	131	14853	5.27	0	NA	NA	NA	NA	Belongs to the ubiquitin-conjugating enzyme family.	NA	PE5	15
+NX_H0YL14	Transmembrane protein 250	139	16083	10.48	2	Membrane;Cytoplasm;Nucleoplasm;Nucleus	NA	(Microbial infection) Promotes human herpes simplex virus 1/HHV-1 proliferation.;May play a role in cell proliferation by promoting progression into S phase.	NA	NA	NA	PE1	9
+NX_H0YM25	Golgin subfamily A member 6-like protein 22	810	102665	4.95	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE1	15
+NX_H3BMG3	Small lysine-rich protein 1	65	7091	10.3	0	Nucleolus	NA	NA	NA	NA	NA	PE2	7
+NX_H3BN30	Uncharacterized protein C16orf97	126	14216	9.41	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_H3BNL1	Uncharacterized protein C3orf84	204	23376	9.32	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_H3BNL8	Armadillo-like helical domain-containing protein 2	230	26547	9.09	0	NA	NA	NA	NA	NA	NA	PE1	6
+NX_H3BPF8	Golgin subfamily A member 8S	625	70417	7.67	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE2	15
+NX_H3BPM6	MKRN2 opposite strand protein	223	25451	5.83	0	Golgi apparatus	NA	NA	NA	NA	NA	PE2	3
+NX_H3BQB6	Stathmin domain-containing protein 1	276	30984	8.61	0	Cytoskeleton	NA	NA	NA	NA	NA	PE1	6
+NX_H3BQJ8	Lymphocyte antigen 6L	138	15317	9.07	0	Cell membrane	NA	NA	NA	NA	NA	PE2	8
+NX_H3BQL2	Golgin subfamily A member 8T	631	71644	7.69	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE2	15
+NX_H3BQW9	Protein FAM229A	127	12972	7.75	0	NA	NA	NA	NA	Belongs to the FAM229 family.	NA	PE2	1
+NX_H3BR10	Small leucine-rich protein 1	107	12312	10.43	2	Membrane	NA	NA	NA	NA	NA	PE1	6
+NX_H3BRN8	Uncharacterized protein C15orf65	121	13763	8.49	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	15
+NX_H3BS89	Transmembrane protein 178B	294	33409	9.45	3	Membrane;Cytoplasmic vesicle;Nucleolus	NA	NA	NA	Belongs to the TMEM178 family.	NA	PE1	7
+NX_H3BSY2	Golgin subfamily A member 8M	632	71498	6.65	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE2	15
+NX_H3BTG2	Testis-expressed protein 46	121	14053	9.86	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_H3BU77	Coiled-coil domain-containing protein 179	68	8104	9.78	0	NA	NA	NA	NA	NA	NA	PE2	11
+NX_H3BUK9	POTE ankyrin domain family member B2	544	61708	5.75	0	NA	NA	NA	NA	Belongs to the POTE family.	NA	PE1	15
+NX_H3BV12	Golgin subfamily A member 8Q	632	71646	5.98	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE2	15
+NX_H3BV60	Transforming growth factor-beta receptor type 3-like protein	316	32819	11.72	1	Membrane;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	19
+NX_H7BZ55	Putative ciliary rootlet coiled-coil protein 2	1655	185872	5.42	0	NA	NA	NA	NA	Belongs to the rootletin family.	NA	PE5	2
+NX_H7C241	Claudin-34	214	24226	8.21	4	Tight junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	NA	PE2	X
+NX_H7C350	Coiled-coil domain-containing protein 188	402	43548	8.61	1	Membrane;Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	22
+NX_I0J062	Proapoptotic nucleolar protein 1	215	22842	12.21	0	Nucleolus	NA	Apoptosis-inducing protein that modulates the tumor suppressor function of CDKN2A/p14ARF. Enhances the stability of CDKN2A/p14ARF protein by protecting it from degradation. May act as a tumor suppressor (PubMed:22094112).	NA	NA	NA	PE2	11
+NX_I1YAP6	Tripartite motif-containing protein 77	450	52450	8.59	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE2	11
+NX_I3L0S3	Putative uncharacterized protein PYCARD-AS1	204	21949	11.32	0	NA	NA	NA	NA	NA	NA	PE5	16
+NX_I3L1E1	Uncharacterized protein C19orf84	186	19614	6.96	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	19
+NX_I3L273	Golgi-associated olfactory signaling regulator	518	56104	5.64	1	Golgi apparatus membrane	NA	Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling (By similarity).	NA	NA	NA	PE1	19
+NX_I3L3R5	Coiled-coil domain-containing glutamate-rich protein 2	266	30352	5.22	0	Secreted	NA	NA	NA	NA	NA	PE1	19
+NX_I6L899	Golgin subfamily A member 8R	631	71490	5.98	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE1	15
+NX_J3KSC0	Putative uncharacterized protein encoded by LINC01387	135	14903	7.65	0	NA	NA	NA	NA	NA	NA	PE5	18
+NX_K7EIQ3	Uncharacterized protein ZNF561-AS1	104	11601	8.99	0	NA	NA	NA	NA	NA	NA	PE4	19
+NX_K7EJ46	Small integral membrane protein 22	83	9249	6.05	1	Membrane;Nucleoplasm;Cytosol;Late endosome	NA	May modulate lipid droplet formation throught interaction with SQLE.	NA	NA	NA	PE1	16
+NX_K9M1U5	Interferon lambda-4	179	19675	11.29	0	Cytoplasm;Secreted	NA	Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes.	NA	Belongs to the lambda interferon family.	NA	PE1	19
+NX_L0R6Q1	SLC35A4 upstream open reading frame protein	103	11133	7.81	1	Membrane	NA	NA	NA	NA	NA	PE1	5
+NX_L0R819	ASNSD1 upstream open reading frame protein	96	11250	8.83	0	Cytoplasm	NA	NA	NA	NA	NA	PE1	2
+NX_L0R8F8	MIEF1 upstream open reading frame protein	70	8445	10.59	0	Mitochondrion matrix	NA	Involved in the regulation of mitochondrial fission mediated by DNM1L (PubMed:29083303). Positively regulates mitochondrial translation (PubMed:30215512). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable).	NA	Belongs to the complex I LYR family.	NA	PE1	22
+NX_M0QZC1	RING finger protein 225	329	34789	9.43	1	Membrane	NA	NA	NA	NA	NA	PE2	19
+NX_M0R2J8	Doublecortin domain-containing protein 1	1783	200591	9.04	0	Spindle;Midbody;Midbody ring	NA	Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412).	NA	NA	NA	PE1	11
+NX_M5A8F1	Suppressyn	160	18128	9.24	0	Secreted	NA	May play a role in trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development. May negatively regulate cell-cell fusion by interacting with SLC1A5, the probable receptor on the cell surface of the fusogenic syncytin-1/ERVW-1.	NA	NA	NA	PE1	21
+NX_O00110	Putative transcription factor ovo-like protein 3	214	23826	10.2	0	Nucleus	NA	May act as a transcription regulator.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE2	19
+NX_O00115	Deoxyribonuclease-2-alpha	360	39581	8.3	0	Lysosome	NA	Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.	Glycosylated. Mutations that eliminate N-glycosylation sites reduce activity, but enzymatic deglycosylation has no effect.	Belongs to the DNase II family.	Lysosome;Lysosome Vesicle Biogenesis	PE1	19
+NX_O00116	Alkyldihydroxyacetonephosphate synthase, peroxisomal	658	72912	6.99	0	Peroxisome;Peroxisome membrane	Rhizomelic chondrodysplasia punctata 3	Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. Alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis.	NA	Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Glycerolipid metabolism; ether lipid biosynthesis.;Ether lipid metabolism;Metabolic pathways;Peroxisome;Plasmalogen biosynthesis;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins	PE1	2
+NX_O00124	UBX domain-containing protein 8	270	30541	7.63	2	Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum membrane;Nucleolus	NA	Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction.	NA	NA	NA	PE1	8
+NX_O00139	Kinesin-like protein KIF2A	706	79955	6.28	0	Cytoplasm;Nucleolus;Nucleoplasm;Spindle pole;Centrosome;Spindle	Cortical dysplasia, complex, with other brain malformations 3	Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.	KIF2A is phosphorylated by AURKA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);KIF2A is phosphorylated by PLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.	Separation of Sister Chromatids;MHC class II antigen presentation;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-dependent Golgi-to-ER retrograde traffic	PE1	5
+NX_O00141	Serine/threonine-protein kinase Sgk1	431	48942	8.7	0	Cytoplasm;Endoplasmic reticulum membrane;Mitochondrion;Nucleus speckle;Cell membrane;Nucleus	NA	Exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1.;Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy.	Shows enhanced stability.;Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells.;Regulated by phosphorylation. Activated by phosphorylation on Ser-422 by mTORC2, transforming it into a substrate for PDPK1 which phosphorylates it on Thr-256. Phosphorylation on Ser-397 and Ser-401 are also essential for its activity. Phosphorylation on Ser-78 by MAPK7 is required for growth factor-induced cell cycle progression.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Aldosterone-regulated sodium reabsorption;Stimuli-sensing channels;Regulation of TP53 Degradation;Transcriptional Regulation by MECP2	PE1	6
+NX_O00142	Thymidine kinase 2, mitochondrial	265	31005	8.71	0	Mitochondrion	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3;Mitochondrial DNA depletion syndrome 2	Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents.	NA	Belongs to the DCK/DGK family.	Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine salvage	PE1	16
+NX_O00144	Frizzled-9	591	64466	8.63	7	Cell membrane	NA	Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity).	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.	Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Class B/2 (Secretin family receptors)	PE1	7
+NX_O00148	ATP-dependent RNA helicase DDX39A	427	49130	5.46	0	Cytoplasm;Nucleus	NA	Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus.	NA	Belongs to the DEAD box helicase family. DECD subfamily.	Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	19
+NX_O00151	PDZ and LIM domain protein 1	329	36072	6.56	0	Cytoplasm;Cell membrane;Cell junction;Z line;Cytoskeleton	NA	Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity).	NA	NA	NA	PE1	10
+NX_O00154	Cytosolic acyl coenzyme A thioester hydrolase	380	41796	8.85	0	Nucleoplasm;Cytoplasm;Cytosol;Mitochondrion	NA	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:10578051). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051).	NA	NA	Lipid metabolism; fatty acid metabolism.;Fatty acid elongation;Biosynthesis of unsaturated fatty acids;Mitochondrial Fatty Acid Beta-Oxidation	PE1	1
+NX_O00155	Probable G-protein coupled receptor 25	361	38779	9.56	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (s) signalling events	PE1	1
+NX_O00159	Unconventional myosin-Ic	1063	121682	9.46	0	Cytoplasm;Nuclear pore complex;Cell membrane;Stereocilium membrane;Nucleolus;Nucleoplasm;Ruffle;Cytoplasmic vesicle;Nucleus	NA	Is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity).;Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.	Contains a N-acetylmethionine at position 1.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Regulation of actin dynamics for phagocytic cup formation;Translocation of SLC2A4 (GLUT4) to the plasma membrane;B-WICH complex positively regulates rRNA expression	PE1	17
+NX_O00160	Unconventional myosin-If	1098	124844	9.21	0	NA	NA	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	19
+NX_O00161	Synaptosomal-associated protein 23	211	23354	4.89	0	Synaptosome;Cell membrane	NA	Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.	NA	Belongs to the SNAP-25 family.	SNARE interactions in vesicular transport;ER-Phagosome pathway;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Neutrophil degranulation;trans-Golgi Network Vesicle Budding	PE1	15
+NX_O00165	HCLS1-associated protein X-1	279	31621	4.76	0	Cytoplasm;Cell cortex;Mitochondrion;Cell membrane;Nucleus membrane;Sarcoplasmic reticulum;Endoplasmic reticulum;P-body;Cytoplasmic vesicle;Nucleus	Neutropenia, severe congenital 3, autosomal recessive	Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.	Proteolytically cleaved by caspase-3 during apoptosis.	Belongs to the HAX1 family.	NA	PE1	1
+NX_O00167	Eyes absent homolog 2	538	59232	6.02	0	Cytoplasm;Cytosol;Nucleus	NA	Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905).	NA	Belongs to the HAD-like hydrolase superfamily. EYA family.	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	PE1	20
+NX_O00168	Phospholemman	92	10441	9.35	1	T-tubule;Apical cell membrane;Nucleolus;Nucleoplasm;Caveola;Cytosol;Sarcolemma	NA	Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.	Palmitoylation increases half-life and stability and is enhanced upon phosphorylation at Ser-88 by PKA.;Major plasma membrane substrate for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) in several different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation (By similarity). Phosphorylation at Ser-88 stimulates sodium/potassium-transporting ATPase activity while the unphosphorylated form inhibits sodium/potassium-transporting ATPase activity (By similarity). Phosphorylation increases tetramerization, decreases binding to ATP1A1 and reduces inhibition of ATP1A1 activity (By similarity). Phosphorylation at Ser-83 leads to greatly reduced interaction with ATP1A1, ATP1A2 and ATP1A3 (By similarity). May be phosphorylated by DMPK (PubMed:10811636).;FXYD1 is phosphorylated by DMPK	Belongs to the FXYD family.	Ion transport by P-type ATPases;Ion homeostasis	PE1	19
+NX_O00170	AH receptor-interacting protein	330	37636	5.88	0	Cytoplasm;Cytosol	Prolactin-secreting pituitary adenoma;Pituitary adenoma 1, multiple types	Cellular negative regulator of the hepatitis B virus (HBV) X protein.;May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.	NA	NA	Aryl hydrocarbon receptor signalling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	11
+NX_O00175	C-C motif chemokine 24	119	13134	10	0	Secreted	NA	Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.	N-glycosylated.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway	PE1	7
+NX_O00178	GTP-binding protein 1	669	72454	8.6	0	Golgi apparatus;Cytoplasm;Cytosol;Nucleus	NA	Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.	NA	PE1	22
+NX_O00180	Potassium channel subfamily K member 1	336	38143	5.94	4	Cell membrane;Recycling endosome;Perikaryon;Cell projection;Synapse;Cytoplasmic vesicle;Apical cell membrane;Dendrite	NA	Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478).	Sumoylation is controversial. Sumoylated by UBE2I (PubMed:15820677). Not sumoylated when expressed in xenopus oocytes or mammalian cells (PubMed:17693262). Sumoylation inactivates the channel, but does not interfere with expression at the cell membrane (PubMed:15820677). Sumoylation of a single subunit is sufficient to silence the dimeric channel (PubMed:20498050, PubMed:23169818). Sumoylation of KCNK1 is sufficient to silence heterodimeric channels formed by KCNK1 and KCNK3 or KCNK9 (PubMed:23169818). Desumoylated by SENP1; this activates the channel (PubMed:15820677, PubMed:20498050, PubMed:23169818). Desumoylated by SENP1; this strongly increases halothane-mediated activation of heterodimeric channels formed with KCNK9 (PubMed:23169818). SENP1 treatment has no effect (PubMed:17693262).	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK);Phase 4 - resting membrane potential	PE1	1
+NX_O00182	Galectin-9	355	39518	9.34	0	Cytoplasm;Secreted;Nucleus	NA	Acts as an eosinophil chemoattractant (PubMed:9642261). It also inhibits angiogenesis (PubMed:24333696). Suppresses IFNG production by natural killer cells (By similarity).;Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity).	NA	NA	Interleukin-2 family signaling	PE1	17
+NX_O00186	Syntaxin-binding protein 3	592	67764	7.98	0	Nucleoplasm;Cytosol;Cell membrane	NA	Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.	Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.	Belongs to the STXBP/unc-18/SEC1 family.	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Disinhibition of SNARE formation	PE1	1
+NX_O00187	Mannan-binding lectin serine protease 2	686	75702	5.39	0	Golgi apparatus;Secreted	MASP2 deficiency	Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.;Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage.	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Staphylococcus aureus infection;Initial triggering of complement;Lectin pathway of complement activation;Ficolins bind to repetitive carbohydrate structures on the target cell surface	PE1	1
+NX_O00189	AP-4 complex subunit mu-1	453	49977	6.71	0	Early endosome;trans-Golgi network membrane	Spastic paraplegia 50, autosomal recessive	Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity).	NA	Belongs to the adaptor complexes medium subunit family.	Lysosome;Lysosome Vesicle Biogenesis	PE1	7
+NX_O00192	Armadillo repeat protein deleted in velo-cardio-facial syndrome	962	104642	6.38	0	Cell junction;Cell membrane	NA	Involved in protein-protein interactions at adherens junctions.	NA	Belongs to the beta-catenin family.	NA	PE1	22
+NX_O00193	Small acidic protein	183	20333	4.57	0	Endoplasmic reticulum;Nucleoplasm	NA	NA	NA	Belongs to the SMAP family.	NA	PE1	11
+NX_O00194	Ras-related protein Rab-27B	218	24608	5.35	0	Golgi apparatus;Cell membrane;Membrane;Late endosome;Cytosol	NA	Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the associaton of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).	NA	Belongs to the small GTPase superfamily. Rab family.	Pancreatic secretion;Platelet degranulation;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	18
+NX_O00198	Activator of apoptosis harakiri	91	9884	11.75	1	Membrane;Mitochondrion	NA	Promotes apoptosis.	NA	NA	NA	PE1	12
+NX_O00203	AP-3 complex subunit beta-1	1094	121320	5.75	0	Golgi apparatus;Nucleoplasm;Clathrin-coated vesicle membrane	Hermansky-Pudlak syndrome 2	Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.	Phosphorylated on serine residues.	Belongs to the adaptor complexes large subunit family.	Lysosome;Golgi Associated Vesicle Biogenesis;Signaling by BRAF and RAF fusions	PE1	5
+NX_O00204	Sulfotransferase 2B1	365	41308	5.24	0	Cytoplasmic vesicle;Cytosol;Nucleus;Microsome	Ichthyosis, congenital, autosomal recessive 14	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:19589875, PubMed:12145317). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:9799594, PubMed:12145317, PubMed:21855633, PubMed:16855051). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).;Sulfonates pregnenolone but not cholesterol.	Phosphorylated.	Belongs to the sulfotransferase 1 family.	Steroid hormone biosynthesis;Sulfur metabolism;Cytosolic sulfonation of small molecules	PE1	19
+NX_O00206	Toll-like receptor 4	839	95680	5.88	1	Ruffle;Golgi apparatus;Early endosome;Cell membrane	NA	Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634, PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor (PubMed:16622205).	Phosphorylated on tyrosine residues by LYN after binding lipopolysaccharide.;N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell surface and the LPS-response. Likewise, mutants lacking two or more of the other N-glycosylation sites were deficient in interaction with LPS.	Belongs to the Toll-like receptor family.	Phagosome;Toll-like receptor signaling pathway;Pathogenic Escherichia coli infection;Salmonella infection;Pertussis;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);Malaria;Toxoplasmosis;Amoebiasis;Tuberculosis;Measles;Influenza A;Rheumatoid arthritis;ER-Phagosome pathway;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);Toll Like Receptor 4 (TLR4) Cascade;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;Caspase activation via Death Receptors in the presence of ligand;MyD88-independent TLR4 cascade;TRIF-mediated programmed cell death;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Regulation of TLR by endogenous ligand	PE1	9
+NX_O00212	Rho-related GTP-binding protein RhoD	210	23413	8.15	0	Early endosome;Cell membrane	NA	Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.	NA	Belongs to the small GTPase superfamily. Rho family.	Axon guidance;RHO GTPases Activate Formins;Rho GTPase cycle	PE1	11
+NX_O00213	Amyloid-beta A4 precursor protein-binding family B member 1	710	77244	4.98	0	Cytoplasm;Nucleus speckle;Cell membrane;Growth cone;Nucleus	NA	Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).	Polyubiquitination by RNF157 leads to degradation by the proteasome (PubMed:25342469).;Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). Phosphorylated following nuclear translocation. Phosphorylation at Tyr-547 by ABL1 enhances transcriptional activation activity and reduces the affinity for RASD1/DEXRAS1.	NA	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	PE1	11
+NX_O00214	Galectin-8	317	35808	8.33	0	Cytoplasmic vesicle;Cytosol	NA	Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).	NA	NA	NA	PE1	1
+NX_O00217	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	210	23705	6	0	Mitochondrion	Mitochondrial complex I deficiency, nuclear type 2	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.	NA	Belongs to the complex I 23 kDa subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	11
+NX_O00219	Hyaluronan synthase 3	553	62998	8.77	7	Membrane;Cytoskeleton	NA	Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).	NA	Belongs to the NodC/HAS family.	Glycan biosynthesis; hyaluronan biosynthesis.;Hyaluronan biosynthesis and export	PE1	16
+NX_O00220	Tumor necrosis factor receptor superfamily member 10A	468	50089	6.64	1	Membrane;Nucleoplasm	NA	Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.	NA	NA	Cytokine-cytokine receptor interaction;Apoptosis;Natural killer cell mediated cytotoxicity;Measles;Influenza A;Cell surface interactions at the vascular wall;Caspase activation via Death Receptors in the presence of ligand;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TRAIL signaling;TP53 Regulates Transcription of Death Receptors and Ligands	PE1	8
+NX_O00221	NF-kappa-B inhibitor epsilon	500	52864	6.22	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleolus	NA	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.	Serine phosphorylated; followed by proteasome-dependent degradation.	Belongs to the NF-kappa-B inhibitor family.	T cell receptor signaling pathway;B cell receptor signaling pathway;Neurotrophin signaling pathway;Adipocytokine signaling pathway;Activation of NF-kappaB in B cells	PE1	6
+NX_O00222	Metabotropic glutamate receptor 8	908	101741	8.49	7	Cell membrane	NA	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.	NA	Belongs to the G-protein coupled receptor 3 family.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	7
+NX_O00230	Cortistatin	105	11532	8.84	0	Secreted	NA	Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.	NA	Belongs to the somatostatin family.	G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	1
+NX_O00231	26S proteasome non-ATPase regulatory subunit 11	422	47464	6.08	0	Golgi apparatus;Nucleoplasm;Cytosol;Nucleus	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.	Phosphorylated by AMPK.	Belongs to the proteasome subunit S9 family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination & Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	17
+NX_O00232	26S proteasome non-ATPase regulatory subunit 12	456	52904	7.53	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Stankiewicz-Isidor syndrome	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.	NA	Belongs to the proteasome subunit p55 family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination & Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	17
+NX_O00233	26S proteasome non-ATPase regulatory subunit 9	223	24682	6.46	0	Cytosol;Cell membrane	NA	Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.	NA	Belongs to the proteasome subunit p27 family.	Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination & Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	12
+NX_O00237	E3 ubiquitin-protein ligase RNF103	685	79405	5.45	4	Endoplasmic reticulum membrane	NA	Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.	NA	NA	Protein modification; protein ubiquitination.;ER Quality Control Compartment (ERQC)	PE1	2
+NX_O00238	Bone morphogenetic protein receptor type-1B	502	56930	7.78	1	Membrane;Cell membrane	Brachydactyly A1, D;Brachydactyly A2;Acromesomelic dysplasia, Demirhan type	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.	NA	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Signaling by BMP	PE1	4
+NX_O00241	Signal-regulatory protein beta-1	398	43211	6.06	1	Cytoplasmic vesicle;Cell membrane	NA	Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985).	N-glycosylated.	NA	Osteoclast differentiation;Signal regulatory protein family interactions;DAP12 interactions;Neutrophil degranulation	PE1	20
+NX_O00244	Copper transport protein ATOX1	68	7402	6.71	0	Cytoplasm;Nucleoplasm;Nucleus;Cell membrane	NA	Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.	NA	Belongs to the ATX1 family.	Mineral absorption;Detoxification of Reactive Oxygen Species;Ion influx/efflux at host-pathogen interface	PE1	5
+NX_O00253	Agouti-related protein	132	14440	7.44	0	Golgi apparatus lumen;Secreted	Obesity	Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.	NA	NA	Adipocytokine signaling pathway;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	16
+NX_O00254	Proteinase-activated receptor 3	374	42508	8.56	7	Endoplasmic reticulum;Cell membrane	NA	Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.	A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events;Thrombin signalling through proteinase activated receptors (PARs)	PE1	5
+NX_O00255	Menin	615	68023	6.14	0	Nucleoplasm;Cytosol;Nucleus	Familial multiple endocrine neoplasia type I	Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.	NA	NA	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);RHO GTPases activate IQGAPs;Post-translational protein phosphorylation	PE1	11
+NX_O00257	E3 SUMO-protein ligase CBX4	560	61368	9.41	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity).;E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850).	Phosphorylated on Thr-497 by HIPK2 upon DNA damage. This phosphorylation stimulates E3 SUMO-protein ligase activity and promotes sumoylation on Lys-494, as well as sumoylation of other target proteins, such as HNRNPK.	NA	Protein modification; protein sumoylation.;SUMOylation of DNA damage response and repair proteins;Oxidative Stress Induced Senescence;SUMOylation of RNA binding proteins;SUMOylation of chromatin organization proteins;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins	PE1	17
+NX_O00258	Tail-anchored protein insertion receptor WRB	174	19780	9.71	3	Endoplasmic reticulum membrane	NA	Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.	NA	Belongs to the WRB/GET1 family.	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	21
+NX_O00264	Membrane-associated progesterone receptor component 1	195	21671	4.56	1	Microsome membrane;Endoplasmic reticulum;Smooth endoplasmic reticulum membrane;Nucleolus	NA	Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs).	NA	Belongs to the cytochrome b5 family. MAPR subfamily.	Neutrophil degranulation	PE1	X
+NX_O00267	Transcription elongation factor SPT5	1087	121000	4.95	0	Nucleoplasm;Nucleus	NA	Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.	Phosphorylated by CDK7 and CDK9. Phosphorylation by P-TEFb alleviates transcriptional pausing and can stimulate transcriptional elongation from the HIV-1 LTR. P-TEFb dependent phosphorylation is stimulated by the HIV-1 Tat protein. Phosphorylation may also stimulate interaction with PIN1. Bulk phosphorylation occurs predominantly in mitosis.;Methylated by PRMT1/HRMT1L2 and PRMT5/SKB1. Methylation negatively regulates interaction with P-TEFb and RNA polymerase II.;SUPT5H is phosphorylated by CDK7	Belongs to the SPT5 family.	Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;RNA polymerase II transcribes snRNA genes;TP53 Regulates Transcription of DNA Repair Genes	PE1	19
+NX_O00268	Transcription initiation factor TFIID subunit 4	1085	110114	9.95	0	Nucleoplasm;Nucleus	NA	Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.	NA	Belongs to the TAF4 family.	Basal transcription factors;Huntington's disease;Herpes simplex infection;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation	PE1	20
+NX_O00270	12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor	319	35075	9.37	7	Cell membrane	NA	High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Free fatty acid receptors	PE2	6
+NX_O00273	DNA fragmentation factor subunit alpha	331	36522	4.68	0	Cytoplasm;Cytosol;Cell membrane	NA	Inhibitor of the caspase-activated DNase (DFF40).	Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.	NA	Apoptosis;Apoptosis induced DNA fragmentation	PE1	1
+NX_O00287	Regulatory factor X-associated protein	272	28232	5.41	0	Nucleus speckle;Nucleus	Bare lymphocyte syndrome 2	Part of the RFX complex that binds to the X-box of MHC II promoters.	Phosphorylated.	NA	Antigen processing and presentation;Tuberculosis;Primary immunodeficiency	PE1	13
+NX_O00291	Huntingtin-interacting protein 1	1037	116221	5.2	0	Cytoplasm;Endomembrane system;Clathrin-coated vesicle membrane;Cytoplasmic vesicle;Nucleus	NA	Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454).	HIP1 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the SLA2 family.	Huntington's disease;Clathrin-mediated endocytosis	PE1	7
+NX_O00292	Left-right determination factor 2	366	40920	8.91	0	Secreted	Left-right axis malformations	Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.	The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.	Belongs to the TGF-beta family.	TGF-beta signaling pathway;Platelet degranulation;Signaling by NODAL;Regulation of signaling by NODAL	PE1	1
+NX_O00294	Tubby-related protein 1	542	60609	9.49	0	Cytoplasm;Secreted;Synapse;Cell membrane	Retinitis pigmentosa 14;Leber congenital amaurosis 15	Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.	NA	Belongs to the TUB family.	NA	PE1	6
+NX_O00295	Tubby-related protein 2	520	58664	8.31	0	Cytoplasm;Secreted	NA	NA	NA	Belongs to the TUB family.	NA	PE1	19
+NX_O00299	Chloride intracellular channel protein 1	241	26923	5.09	1	Cytoplasm;Cell membrane;Nucleus membrane;Cytosol;Nucleus	NA	Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.	Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.	Belongs to the chloride channel CLIC family.	NA	PE1	6
+NX_O00300	Tumor necrosis factor receptor superfamily member 11B	401	46026	8.66	0	Secreted	Paget disease of bone 5, juvenile-onset	Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.	The N-terminus is blocked.;N-glycosylated. Contains sialic acid residues.	NA	Cytokine-cytokine receptor interaction;Osteoclast differentiation;TNFs bind their physiological receptors	PE1	8
+NX_O00303	Eukaryotic translation initiation factor 3 subunit F	357	37564	5.24	0	Cytoplasm	Intellectual developmental disorder, autosomal recessive 67	Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.;Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).	Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11.	Belongs to the eIF-3 subunit F family.	RNA transport;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	11
+NX_O00305	Voltage-dependent L-type calcium channel subunit beta-4	520	58169	9.37	0	NA	Juvenile myoclonic epilepsy 6;Epilepsy, idiopathic generalized 9;Episodic ataxia 5	The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.	CACNB4 is phosphorylated by CAMK2D (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the calcium channel beta subunit family.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;NCAM1 interactions;Presynaptic depolarization and calcium channel opening;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	2
+NX_O00308	NEDD4-like E3 ubiquitin-protein ligase WWP2	870	98912	6.67	0	Nucleus	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.	Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome.	NA	Protein modification; protein ubiquitination.;Regulation of PTEN stability and activity;NOTCH3 Activation and Transmission of Signal to the Nucleus	PE1	16
+NX_O00311	Cell division cycle 7-related protein kinase	574	63888	8.96	0	Nucleoplasm;Spindle;Nucleus;Cytoskeleton	NA	Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.	Cell cycle;Activation of ATR in response to replication stress;Activation of the pre-replicative complex;Transcriptional Regulation by E2F6	PE1	1
+NX_O00321	ETS translocation variant 2	342	36633	5.88	0	Nucleus	NA	Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.	NA	Belongs to the ETS family.	NA	PE2	19
+NX_O00322	Uroplakin-1a	258	28879	5.16	4	Membrane	NA	Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	19
+NX_O00327	Aryl hydrocarbon receptor nuclear translocator-like protein 1	626	68762	6.4	0	Cytoplasm;Nucleoplasm;PML body;Cytoplasmic vesicle;Nucleus	NA	Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity).	Acetylated on Lys-538 upon dimerization with CLOCK. Acetylation facilitates CRY1-mediated repression. Deacetylated by SIRT1, which may result in decreased protein stability.;Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.;O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-ARNTL/BMAL1 heterodimer thereby increasing CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2/3 and CRY1/2.;Ubiquitinated, leading to its proteasomal degradation (PubMed:24728990). Deubiquitinated by USP9X (PubMed:29626158).;Sumoylated on Lys-259 upon dimerization with CLOCK. Predominantly conjugated to poly-SUMO2/3 rather than SUMO1 and the level of these conjugates undergo rhythmic variation, peaking at CT9-CT12. Sumoylation localizes it exclusively to the PML body and promotes its ubiquitination in the PML body, ubiquitin-dependent proteasomal degradation and the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer.;Phosphorylated upon dimerization with CLOCK. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the CLOCK-ARNTL/BMAL1 heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver with a peak between CT10 to CT14. Phosphorylation at Ser-90 by CK2 is essential for its nuclear localization, its interaction with CLOCK and controls CLOCK nuclear entry (By similarity). Dephosphorylation at Ser-78 is important for dimerization with CLOCK and transcriptional activity (PubMed:23229515).	NA	Circadian rhythm - mammal;Dopaminergic synapse;Herpes simplex infection;PPARA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock	PE1	11
+NX_O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	1044	119479	6.79	0	Cytoplasm;Cytoskeleton;Cytoplasmic vesicle	Activated PI3K-delta syndrome	May be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.;Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function.	Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.	Belongs to the PI3/PI4-kinase family.	Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.;Inositol phosphate metabolism;ErbB signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;mTOR signaling pathway;Apoptosis;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Cholinergic synapse;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Carbohydrate digestion and absorption;Bacterial invasion of epithelial cells;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Acute myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Synthesis of PIPs at the plasma membrane;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Interleukin receptor SHC signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Interleukin-3, Interleukin-5 and GM-CSF signaling;Regulation of signaling by CBL;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	PE1	1
+NX_O00330	Pyruvate dehydrogenase protein X component, mitochondrial	501	54122	8.8	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion;Cell membrane	Pyruvate dehydrogenase E3-binding protein deficiency	Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.	Delipoylated at Lys-97 by SIRT4, delipoylation decreases the PHD complex activity.	Belongs to the 2-oxoacid dehydrogenase family.	Metabolic pathways;Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex;Pyruvate metabolism;Glyoxylate metabolism and glycine degradation	PE1	11
+NX_O00337	Sodium/nucleoside cotransporter 1	649	71584	7.77	13	Cell membrane	NA	Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.	NA	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	PE1	15
+NX_O00338	Sulfotransferase 1C2	296	34880	7.12	0	Cytoplasm	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).	NA	Belongs to the sulfotransferase 1 family.	Cytosolic sulfonation of small molecules	PE1	2
+NX_O00339	Matrilin-2	956	106837	5.86	0	Secreted	NA	Involved in matrix assembly.	NA	NA	NA	PE1	8
+NX_O00341	Excitatory amino acid transporter 5	560	60658	6.33	10	Membrane	NA	Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.	NA	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A7 subfamily.	Glutamatergic synapse;Glutamate Neurotransmitter Release Cycle;Transport of inorganic cations/anions and amino acids/oligopeptides	PE2	1
+NX_O00358	Forkhead box protein E1	373	38076	9.62	0	Nucleus	Thyroid cancer, non-medullary, 4;Bamforth-Lazarus syndrome	Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.	Phosphorylated.	NA	NA	PE1	9
+NX_O00370	LINE-1 retrotransposable element ORF2 protein	1275	149012	9.68	0	NA	NA	Has a reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome.	NA	NA	NA	PE1	unknown
+NX_O00391	Sulfhydryl oxidase 1	747	82578	9.13	1	Golgi apparatus;Cytoplasmic vesicle;Secreted;Golgi apparatus membrane	NA	Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277).	N-glycosylated (PubMed:17331072, PubMed:29757379). O-glycosylated on Thr and Ser residues (PubMed:29757379).	Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.	Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation	PE1	1
+NX_O00398	Putative P2Y purinoceptor 10	339	38774	9.26	7	Cell membrane	NA	Putative receptor for purines coupled to G-proteins.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;P2Y receptors	PE1	X
+NX_O00399	Dynactin subunit 6	190	20747	5.94	0	Cell membrane;Nucleolus;Cytosol;Kinetochore;Cytoskeleton	NA	NA	Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.	Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.	Vasopressin-regulated water reabsorption;MHC class II antigen presentation;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	8
+NX_O00400	Acetyl-coenzyme A transporter 1	549	60909	6.98	11	Nucleoplasm;Endoplasmic reticulum membrane	Congenital cataracts, hearing loss, and neurodegeneration;Spastic paraplegia 42, autosomal dominant	Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:9096318). Negatively regulates BMP signaling (PubMed:25402622).	NA	Belongs to the SLC33A transporter family.	Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Transport of vitamins, nucleosides, and related molecules;Defective SLC33A1 causes spastic paraplegia 42 (SPG42)	PE1	3
+NX_O00401	Neural Wiskott-Aldrich syndrome protein	505	54827	8.05	0	Cytoplasm;Nucleolus;Cytosol;Nucleus;Cytoskeleton	NA	Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:9422512, PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:9422512, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742).	Phosphorylation at Ser-242, Tyr-256, Ser-484 and Ser-485 enhances actin polymerization activity.;WASL is phosphorylated by MAPK3	NA	Chemokine signaling pathway;Adherens junction;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;EPHB-mediated forward signaling;Nephrin family interactions;NOSTRIN mediated eNOS trafficking;DCC mediated attractive signaling;Clathrin-mediated endocytosis	PE1	7
+NX_O00408	cGMP-dependent 3',5'-cyclic phosphodiesterase	941	105717	5.22	0	Mitochondrion outer membrane;Cytoplasm;Mitochondrion;Cell membrane;Mitochondrion matrix;Cytosol;Mitochondrion inner membrane	NA	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. Pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027).;Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107).	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.	Purine metabolism;G alpha (s) signalling events;cGMP effects	PE1	11
+NX_O00409	Forkhead box protein N3	490	53835	6.19	0	Nucleoplasm;Nucleus;Cell membrane	NA	Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).	NA	NA	NA	PE1	14
+NX_O00410	Importin-5	1097	123630	4.83	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.	NA	Belongs to the importin beta family. Importin beta-3 subfamily.	vRNP Assembly	PE1	13
+NX_O00411	DNA-directed RNA polymerase, mitochondrial	1230	138620	9.19	0	Mitochondrion	NA	DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates.	NA	Belongs to the phage and mitochondrial RNA polymerase family.	Transcriptional activation of mitochondrial biogenesis;Mitochondrial transcription initiation	PE1	19
+NX_O00418	Eukaryotic elongation factor 2 kinase	725	82144	5.16	0	Nucleoplasm	NA	Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.	Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis.	Belongs to the protein kinase superfamily. Alpha-type protein kinase family.	mTORC1-mediated signalling	PE1	16
+NX_O00421	C-C chemokine receptor-like 2	344	39513	7.92	7	Cell membrane	NA	Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.	NA	Belongs to the G-protein coupled receptor 1 family.	Chemokine receptors bind chemokines	PE1	3
+NX_O00422	Histone deacetylase complex subunit SAP18	153	17561	9.38	0	Cytoplasm;Nucleus speckle;Nucleoplasm;Cytosol;Nucleus	NA	Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.	NA	Belongs to the SAP18 family.	RNA transport;mRNA surveillance pathway;NoRC negatively regulates rRNA expression;HDACs deacetylate histones	PE1	13
+NX_O00423	Echinoderm microtubule-associated protein-like 1	815	89861	6.61	0	Cytoplasm;Perinuclear region;Cytoskeleton	Band heterotopia	Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.	NA	Belongs to the WD repeat EMAP family.	NA	PE1	14
+NX_O00425	Insulin-like growth factor 2 mRNA-binding protein 3	579	63705	8.99	0	Cytoplasm;Cytosol;Nucleus	NA	RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.	NA	Belongs to the RRM IMP/VICKZ family.	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	PE1	7
+NX_O00429	Dynamin-1-like protein	736	81877	6.37	0	Mitochondrion outer membrane;Golgi apparatus;Endomembrane system;Clathrin-coated pit;Peroxisome;Synaptic vesicle membrane;Cytoplasmic vesicle;Cytosol	Optic atrophy 5;Encephalopathy due to defective mitochondrial and peroxisomal fission 1	Inhibits peroxisomal division when overexpressed.;Inhibits peroxisomal division when overexpressed.;Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Plays an important role in mitochondrial fission during mitosis (PubMed:26992161, PubMed:27301544, PubMed:27328748). Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:23792689). Required for programmed necrosis execution. Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834).	S-nitrosylation increases DNM1L dimerization, mitochondrial fission and causes neuronal damage.;Sumoylated on various lysine residues within the B domain, probably by MUL1. Sumoylation positively regulates mitochondrial fission. Desumoylated by SENP5 during G2/M transition of mitosis. Appears to be linked to its catalytic activity.;O-GlcNAcylation augments the level of the GTP-bound active form of DRP1 and induces translocation from the cytoplasm to mitochondria in cardiomyocytes. It also decreases phosphorylation at Ser-637 (By similarity).;Ubiquitination by MARCH5 affects mitochondrial morphology.;Phosphorylation/dephosphorylation events on two sites near the GED domain regulate mitochondrial fission. Phosphorylation on Ser-637 inhibits the GTPase activity, leading to a defect in mitochondrial fission promoting mitochondrial elongation. Dephosphorylated on this site by PPP3CA which promotes mitochondrial fission. Phosphorylation on Ser-616 activates the GTPase activity and promotes mitochondrial fission. Phosphorylated in a circadian manner at Ser-637 (PubMed:29478834).	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Endocytosis;Fc gamma R-mediated phagocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Bacterial invasion of epithelial cells;Apoptotic execution phase	PE1	12
+NX_O00442	RNA 3'-terminal phosphate cyclase	366	39337	8.01	0	Nucleoplasm	NA	Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.	NA	Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.	NA	PE1	1
+NX_O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	1686	190680	8.25	0	Golgi apparatus;Clathrin-coated vesicle;Cytoplasm;Cell membrane;Nucleoplasm;Nucleus	NA	Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.	Phosphorylated upon insulin stimulation; which may lead to enzyme activation (By similarity). Phosphorylated on Ser-259 during mitosis and upon UV irradiation; which does not change enzymatic activity but leads to proteasomal degradation. Ser-259 phosphorylation may be mediated by CDK1 or JNK, depending on the physiological state of the cell.	Belongs to the PI3/PI4-kinase family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis	PE1	11
+NX_O00444	Serine/threonine-protein kinase PLK4	970	108972	8.79	0	Cleavage furrow;Centriole;Nucleolus;Centrosome;Cytosol	Microcephaly and chorioretinopathy, autosomal recessive, 2	Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).	Acetylation by KAT2A and KAT2B impairs kinase activity by shifting the kinase to an inactive conformation.;Ubiquitinated; leading to its degradation by the proteasome.;Tyrosine-phosphorylated by TEC.;PLK4 is phosphorylated by TEC (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	4
+NX_O00445	Synaptotagmin-5	386	42900	9.27	1	Synaptic vesicle membrane;Recycling endosome membrane	NA	May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).	NA	Belongs to the synaptotagmin family.	Regulation of insulin secretion	PE1	19
+NX_O00451	GDNF family receptor alpha-2	464	51544	8	0	Cytoplasmic vesicle;Cell membrane	NA	Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.;Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.	NA	Belongs to the GDNFR family.	RAF/MAP kinase cascade;NCAM1 interactions;RET signaling	PE1	8
+NX_O00453	Leukocyte-specific transcript 1 protein	97	10792	8.43	1	Membrane;Endomembrane system;Golgi apparatus membrane	NA	Have an inhibitory effect on lymphocyte proliferation.;Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation.	NA	Belongs to the LST1 family.	NA	PE1	6
+NX_O00458	Interferon-related developmental regulator 1	451	50269	6.8	0	Cytosol;Cell membrane	NA	Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity).	NA	Belongs to the IFRD family.	NA	PE1	7
+NX_O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	728	81545	6.03	0	Golgi apparatus	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).	Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.;Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317).	Belongs to the PI3K p85 subunit family.	ErbB signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;mTOR signaling pathway;Apoptosis;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Cholinergic synapse;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Carbohydrate digestion and absorption;Bacterial invasion of epithelial cells;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;G alpha (q) signalling events;Synthesis of PIPs at the plasma membrane;Downstream TCR signaling;PI3K Cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Role of LAT2/NTAL/LAB on calcium mobilization;GPVI-mediated activation cascade;Interleukin-7 signaling;Interleukin receptor SHC signaling;Rho GTPase cycle;DAP12 signaling;VEGFA-VEGFR2 Pathway;CD28 dependent PI3K/Akt signaling;Signaling by SCF-KIT;Role of phospholipids in phagocytosis;Interleukin-3, Interleukin-5 and GM-CSF signaling;Nephrin family interactions;Regulation of signaling by CBL;Tie2 Signaling;Costimulation by the CD28 family;PI3K/AKT activation;Downstream signal transduction;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;IRS-mediated signalling;Extra-nuclear estrogen signaling	PE1	19
+NX_O00461	Golgi integral membrane protein 4	696	81880	4.73	1	Golgi stack membrane;Golgi apparatus;Membrane;Endosome membrane	NA	Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.	O-glycosylated; modified by sialic acid residues.;N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.;Phosphorylated probably by c-AMP-dependent kinases in its lumenal part.	Belongs to the GOLIM4 family.	Intra-Golgi traffic	PE1	3
+NX_O00462	Beta-mannosidase	879	100895	5.33	0	Cytoplasmic vesicle;Lysosome	Mannosidosis, beta A, lysosomal	Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.	NA	Belongs to the glycosyl hydrolase 2 family.	Glycan metabolism; N-glycan degradation.;Other glycan degradation;Lysosome;Lysosomal oligosaccharide catabolism;Neutrophil degranulation	PE1	4
+NX_O00463	TNF receptor-associated factor 5	557	64406	7.26	0	Cytoplasm;Cytosol	NA	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.	NA	Belongs to the TNF receptor-associated factor family. A subfamily.	Herpes simplex infection;Pathways in cancer;Small cell lung cancer	PE1	1
+NX_O00468	Agrin	2068	217320	6.01	0	Cytosol;Extracellular matrix;Synapse;Cell membrane	Myasthenic syndrome, congenital, 8	Lack any 'z' insert, are muscle-specific and may be involved in endothelial cell differentiation.;Agrin N-terminal 110 kDa subunit: is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity).;Neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering.;Transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.;Agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the 'z' isoforms.;Agrin C-terminal 22 kDa fragment: this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia.;Heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.	At synaptic junctions, cleaved at two conserved sites, alpha and beta, by neurotrypsin. Cleavage at the alpha-site produces the agrin N-terminal 110-kDa subunit and the agrin C-terminal 110-kDa subunit. Further cleavage of agrin C-terminal 110-kDa subunit at the beta site produces the C-terminal fragments, agrin C-terminal 90 kDa fragment and agrin C-terminal 22 kDa fragment. Excessive cleavage at the beta-site releases large amounts of the agrin C-terminal 22 kDa fragment leading to destabilization at the neuromuscular junction (NMJ).;Contains heparan and chondroitin sulfate chains and alpha-dystroglycan as well as N-linked and O-linked oligosaccharides. Glycosaminoglycans (GAGs), present in the N-terminal 110 kDa fragment, are required for induction of filopodia in hippocampal neurons. The first cluster (Gly/Ser-rich) for GAG attachment contains heparan sulfate (HS) chains and the second cluster (Ser/Thr-rich), contains chondroitin sulfate (CS) chains. Heparin and heparin sulfate binding in the G3 domain is independent of calcium ions. Binds heparin with a stoichiometry of 2:1. Binds sialic acid with a stoichiometry of 1:1 and binding requires calcium ions (By similarity).	NA	ECM-receptor interaction;Retinoid metabolism and transport;NCAM1 interactions;HS-GAG biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Integrin cell surface interactions;ECM proteoglycans;Non-integrin membrane-ECM interactions;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	1
+NX_O00469	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	737	84686	6.24	0	Cytosol;Rough endoplasmic reticulum membrane;Nucleolus	Bruck syndrome 2	Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.	NA	NA	Lysine degradation;Collagen biosynthesis and modifying enzymes	PE1	3
+NX_O00470	Homeobox protein Meis1	390	43016	5.86	0	Nucleoplasm;Nucleus	Restless legs syndrome 7	Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.	NA	Belongs to the TALE/MEIS homeobox family.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	2
+NX_O00471	Exocyst complex component 5	708	81853	6.27	0	Cytoplasm;Midbody	NA	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	NA	Belongs to the SEC10 family.	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium	PE1	14
+NX_O00472	RNA polymerase II elongation factor ELL2	640	72324	9.09	0	Nucleoplasm;Nucleus	NA	Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.	Ubiquitinated by SIAH1, leading to its degradation by the proteaseome. Interaction with AFF4 stabilizeS ELL2 and prevent ELL2 ubiquitination.	Belongs to the ELL/occludin family.	RNA polymerase II transcribes snRNA genes	PE1	5
+NX_O00476	Sodium-dependent phosphate transport protein 4	420	46106	8.69	8	Endoplasmic reticulum membrane;Cell membrane	NA	Voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A.;Functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.	NA	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.	Stimuli-sensing channels	PE1	6
+NX_O00478	Butyrophilin subfamily 3 member A3	584	65002	5.37	1	Cell membrane	NA	Plays a role in T-cell responses in the adaptive immune response.	N-glycosylated.	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Butyrophilin (BTN) family interactions	PE1	6
+NX_O00479	High mobility group nucleosome-binding domain-containing protein 4	90	9539	10.48	0	Nucleus	NA	NA	NA	Belongs to the HMGN family.	NA	PE1	6
+NX_O00481	Butyrophilin subfamily 3 member A1	513	57677	8.23	1	Cytoplasmic vesicle;Cell membrane	NA	Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.	N-glycosylated.	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Butyrophilin (BTN) family interactions	PE1	6
+NX_O00482	Nuclear receptor subfamily 5 group A member 2	541	61331	8.08	0	Nucleus speckle;Nucleus	NA	Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity).	Sumoylated by SUMO1 at Lys-270 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.	Belongs to the nuclear hormone receptor family. NR5 subfamily.	Maturity onset diabetes of the young;Regulation of gene expression in early pancreatic precursor cells;Nuclear Receptor transcription pathway;Estrogen-dependent gene expression;SUMOylation of intracellular receptors	PE1	1
+NX_O00483	Cytochrome c oxidase subunit NDUFA4	81	9370	9.42	0	Mitochondrion inner membrane	Leigh syndrome	Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance.	NA	Belongs to the complex IV NDUFA4 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	7
+NX_O00487	26S proteasome non-ATPase regulatory subunit 14	310	34577	6.06	0	Nucleoplasm	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.	NA	Belongs to the peptidase M67A family. PSMD14 subfamily.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination & Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	2
+NX_O00488	Zinc finger protein 593	134	15199	9.85	0	Nucleoplasm;Nucleolus	NA	Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.	NA	Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_O00499	Myc box-dependent-interacting protein 1	593	64699	4.97	0	Cytoplasm;T-tubule;Endosome;Cytosol;Nucleus	Myopathy, centronuclear, 2	Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).	Phosphorylated by protein kinase C.	NA	Clathrin-mediated endocytosis	PE1	2
+NX_O00501	Claudin-5	218	23147	8.25	4	Tight junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions;RUNX1 regulates expression of components of tight junctions	PE1	22
+NX_O00505	Importin subunit alpha-4	521	57811	4.8	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.	NA	Belongs to the importin alpha family.	ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways	PE1	13
+NX_O00506	Serine/threonine-protein kinase 25	426	48112	6.27	0	Golgi apparatus;Cytoplasm	NA	Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	NA	PE1	2
+NX_O00507	Probable ubiquitin carboxyl-terminal hydrolase FAF-Y	2555	291077	5.56	0	Cytoplasmic vesicle;Cytoplasm	Spermatogenic failure Y-linked 2	May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).	NA	Belongs to the peptidase C19 family.	NA	PE1	Y
+NX_O00512	B-cell CLL/lymphoma 9 protein	1426	149290	8.99	0	Nucleoplasm;Nucleus	NA	Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).	NA	Belongs to the BCL9 family.	Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex	PE1	1
+NX_O00515	Ladinin-1	517	57131	9.67	0	Basement membrane;Cytoskeleton	NA	Anchoring filament protein which is a component of the basement membrane zone.	NA	NA	NA	PE1	1
+NX_O00519	Fatty-acid amide hydrolase 1	579	63066	7.82	1	Cytosol;Endomembrane system;Cytoskeleton	NA	Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.	NA	Belongs to the amidase family.	Arachidonic acid metabolism	PE1	1
+NX_O00522	Krev interaction trapped protein 1	736	84348	8.63	0	Cytoplasmic vesicle;Cell junction;Cytoskeleton;Cell membrane	Cerebral cavernous malformations 1	Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.	NA	NA	NA	PE1	7
+NX_O00526	Uroplakin-2	184	19438	10.41	1	Endoplasmic reticulum;Cell membrane	NA	Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).	NA	Belongs to the uroplakin-2 family.	NA	PE1	11
+NX_O00533	Neural cell adhesion molecule L1-like protein	1208	135071	5.51	1	Extracellular matrix;Cell membrane	NA	Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity).	N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc) (By similarity).;O-glycosylated.;Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors (By similarity). Cleaved by BACE1 (By similarity).	Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.	CHL1 interactions	PE1	3
+NX_O00534	von Willebrand factor A domain-containing protein 5A	786	86489	6.13	0	Nucleoplasm;Nucleolus	NA	May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.	NA	NA	NA	PE1	11
+NX_O00541	Pescadillo homolog	588	68003	6.93	0	Nucleoplasm;Nucleolus;Chromosome	NA	Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Sumoylated.	Belongs to the pescadillo family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	22
+NX_O00548	Delta-like protein 1	723	78056	5.85	1	Nucleoplasm;Apical cell membrane;Adherens junction;Membrane raft	NA	Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B-cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (PubMed:11581320). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity).	Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity). Ubiquitinated; promotes recycling back to the plasma membrane and confers a strong affinity for NOTCH1. Multi-ubiquitination of LYS-613 by MIB1 promotes both cis and trans-interaction with NOTCH1, as well as activation of Notch signaling. Ubiquitinated by NEURL1B (By similarity).;Phosphorylated in a membrane association-dependent manner. Phosphorylation at Ser-697 requires the presence of Ser-694, whereas phosphorylation at Ser-694 occurs independently of the other site. Phosphorylation is required for full ligand activity in vitro and affects surface presentation, ectodomain shedding, and endocytosis.;O-fucosylated. Can be elongated to a disaccharide by MFNG.	NA	Notch signaling pathway;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;MECP2 regulates transcription of neuronal ligands	PE1	6
+NX_O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	2506	282564	9	24	Endoplasmic reticulum;Cell membrane	Episodic ataxia 2;Migraine, familial hemiplegic, 1;Epileptic encephalopathy, early infantile, 42;Spinocerebellar ataxia 6	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP).	NA	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily.	MAPK signaling pathway;Calcium signaling pathway;Synaptic vesicle cycle;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Long-term depression;Taste transduction;Type II diabetes mellitus;Presynaptic depolarization and calcium channel opening;Regulation of insulin secretion	PE1	19
+NX_O00559	Receptor-binding cancer antigen expressed on SiSo cells	213	24377	6.04	1	Golgi apparatus;Golgi apparatus membrane	NA	May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.	NA	NA	Estrogen-dependent gene expression	PE1	8
+NX_O00560	Syntenin-1	298	32444	7.06	0	Extracellular exosome;Endoplasmic reticulum membrane;Cell membrane;Adherens junction;Focal adhesion;Nucleus membrane;Nucleoplasm;Melanosome;Cytosol;Membrane raft;Nucleus;Cytoskeleton	NA	Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).	Phosphorylated on tyrosine residues.	NA	Ephrin signaling;Neurofascin interactions;Neutrophil degranulation	PE1	8
+NX_O00562	Membrane-associated phosphatidylinositol transfer protein 1	1244	134848	5.64	0	Cytoplasm;Endoplasmic reticulum membrane;Cleavage furrow;Lipid droplet;Golgi stack membrane;Cytosol;Midbody	NA	Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.	Phosphorylated on threonine residues upon treatment with oleic acid.;Phosphorylated on tyrosine residues by PTK2B.;Phosphorylated on multiple sites by CDK1 at the onset of mitosis. Phosphorylation facilitates dissociation from the Golgi complex and is required for interaction with PLK1.	Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.	Synthesis of PI	PE1	11
+NX_O00566	U3 small nucleolar ribonucleoprotein protein MPP10	681	78864	4.77	0	Nucleolus;Chromosome	NA	Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.	Phosphorylated in M (mitotic) phase.	Belongs to the MPP10 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	2
+NX_O00567	Nucleolar protein 56	594	66050	9.24	0	Nucleoplasm;Cytoplasm;Nucleolus	Spinocerebellar ataxia 36	Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs.	NA	Belongs to the NOP5/NOP56 family.	Ribosome biogenesis in eukaryotes;Association of TriC/CCT with target proteins during biosynthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	20
+NX_O00570	Transcription factor SOX-1	391	39023	9.7	0	Nucleus	NA	Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).	NA	NA	NA	PE1	13
+NX_O00571	ATP-dependent RNA helicase DDX3X	662	73243	6.73	0	Mitochondrion outer membrane;Cytoplasm;Nucleus speckle	Mental retardation, X-linked 102	Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5'proximal stem-loop structure in their 5'UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the 40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5'UTRs and is independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location. Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta); proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, plays a role of scaffolding adapter that links IKBKE and IRF3 and coordinates their activation. Also found associated with IFNB promoters; the function is independent of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling in early stages of infection. Involved in regulation of apoptosis. May be required for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an antiapoptotic protein through association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex; activation of death receptors promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition. May be involved in mitotic chromosome segregation. Is an allosteric activator of CSNK1E, it stimulates CSNK1E-mediated phosphorylation of DVL2 and is involved in the positive regulation of canonical Wnt signaling (PubMed:23413191).;(Microbial infection) Appears to be a prime target for viral manipulations. Hepatitis B virus (HBV) polymerase and possibly vaccinia virus (VACV) protein K7 inhibit IFNB induction probably by dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C virus (HCV) replication; the function may involve the association with HCV core protein. HCV core protein inhibits the IPS1-dependent function in viral RNA sensing and may switch the function from a INFB inducing to a HCV replication mode. Involved in HIV-1 replication. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs.	Phosphorylated by TBK1; the phosphorylation is required to synergize with TBK1 in IFNB induction. Phosphorylated by IKBKE at Ser-102 after ssRNA viral infection; enhances the induction of INFB promoter by IRF3. The cytoplasmic form is highly phosphorylated in the G1/S phase and much lower phosphorylated in G2/M.;DDX3X is phosphorylated by TBK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	RIG-I-like receptor signaling pathway;Neutrophil degranulation	PE1	X
+NX_O00574	C-X-C chemokine receptor type 6	342	39280	8.28	7	Cell membrane	NA	Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.	NA	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE2	3
+NX_O00584	Ribonuclease T2	256	29481	6.66	0	Secreted;Endoplasmic reticulum lumen;Lysosome lumen	Leukoencephalopathy, cystic, without megalencephaly	Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.	NA	Belongs to the RNase T2 family.	Neutrophil degranulation	PE1	6
+NX_O00585	C-C motif chemokine 21	134	14646	10.13	0	Secreted	NA	Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	9
+NX_O00587	Beta-1,3-N-acetylglucosaminyltransferase manic fringe	321	36202	9.01	1	Cytoplasmic vesicle;Golgi apparatus membrane	NA	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity).	NA	Belongs to the glycosyltransferase 31 family.	Other types of O-glycan biosynthesis;Notch signaling pathway;Pre-NOTCH Processing in Golgi	PE1	22
+NX_O00590	Atypical chemokine receptor 2	384	43443	7.61	7	Cell membrane;Recycling endosome;Early endosome;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.	Phosphorylated on serine residues in the C-terminal cytoplasmic tail.	Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.	NA	PE1	3
+NX_O00591	Gamma-aminobutyric acid receptor subunit pi	440	50640	6.55	4	Postsynaptic cell membrane;Cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRP sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse	PE1	5
+NX_O00592	Podocalyxin	558	58635	5.28	1	Cell membrane;Centriolar satellite;Membrane;Lamellipodium;Filopodium;Ruffle;Cytoplasmic vesicle;Apical cell membrane;Microvillus;Membrane raft	NA	Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.	N- and O-linked glycosylated. Sialoglycoprotein (By similarity).	Belongs to the podocalyxin family.	NA	PE1	7
+NX_O00602	Ficolin-1	326	35078	6.39	0	Secreted;Cell membrane	NA	Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.	NA	Belongs to the ficolin lectin family.	Initial triggering of complement;Lectin pathway of complement activation;Ficolins bind to repetitive carbohydrate structures on the target cell surface;Neutrophil degranulation	PE1	9
+NX_O00622	CCN family member 1	381	42027	8.64	0	Secreted	NA	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.	NA	Belongs to the CCN family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	1
+NX_O00623	Peroxisome assembly protein 12	359	40797	9.21	2	Peroxisome membrane	Peroxisome biogenesis disorder complementation group 3;Peroxisome biogenesis disorder 3A;Peroxisome biogenesis disorder 3B	Required for protein import into peroxisomes.	NA	Belongs to the pex2/pex10/pex12 family.	Peroxisome;E3 ubiquitin ligases ubiquitinate target proteins;Peroxisomal protein import;Class I peroxisomal membrane protein import	PE1	17
+NX_O00624	Sodium-dependent phosphate transport protein 3	439	47277	8.85	9	Membrane	NA	May be involved in actively transporting phosphate into cells via Na(+) cotransport.	NA	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.	NA	PE1	6
+NX_O00625	Pirin	290	32113	6.42	0	Cytoplasm;Cytosol;Nucleus	NA	Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).	NA	Belongs to the pirin family.	Flavonoid metabolism; quercetin degradation.;Digestion	PE1	X
+NX_O00626	C-C motif chemokine 22	93	10625	8.8	0	Secreted	NA	May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.	The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling	PE1	16
+NX_O00628	Peroxisomal targeting signal 2 receptor	323	35892	5.41	0	Peroxisome;Nucleoplasm;Cytoplasm;Cytoplasmic vesicle	Rhizomelic chondrodysplasia punctata 1;Peroxisome biogenesis disorder complementation group 11;Peroxisome biogenesis disorder 9B	Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.	NA	Belongs to the WD repeat peroxin-7 family.	Peroxisome;Peroxisomal protein import	PE1	6
+NX_O00629	Importin subunit alpha-3	521	57887	4.8	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.	NA	Belongs to the importin alpha family.	ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways	PE1	3
+NX_O00631	Sarcolipin	31	3762	8.34	1	Endoplasmic reticulum membrane;Sarcoplasmic reticulum membrane;Cytoskeleton	NA	Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity).	NA	Belongs to the sarcolipin family.	Ion transport by P-type ATPases;Ion homeostasis	PE1	11
+NX_O00634	Netrin-3	580	61466	9.2	0	Extracellular matrix	NA	Netrins control guidance of CNS commissural axons and peripheral motor axons.	NA	NA	Axon guidance;Myogenesis	PE1	16
+NX_O00635	E3 ubiquitin-protein ligase TRIM38	465	53416	6.61	0	Cell junction;Centrosome;Cell membrane	NA	E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.	NA	NA	Protein modification; protein ubiquitination.;Interferon gamma signaling	PE1	6
+NX_O00712	Nuclear factor 1 B-type	420	47442	9.01	0	Nucleoplasm;Nucleolus;Nucleus	Macrocephaly, acquired, with impaired intellectual development	Transcriptional activator of GFAP, essential for proper brain development (PubMed:30388402). Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	NA	Belongs to the CTF/NF-I family.	RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation	PE1	9
+NX_O00716	Transcription factor E2F3	465	49162	5.29	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).	NA	Belongs to the E2F/DP family.	Cell cycle;HTLV-I infection;Pathways in cancer;Pancreatic cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Oxidative Stress Induced Senescence;CDC6 association with the ORC:origin complex;Pre-NOTCH Transcription and Translation;Oncogene Induced Senescence;Cyclin D associated events in G1;G2 Phase	PE1	6
+NX_O00743	Serine/threonine-protein phosphatase 6 catalytic subunit	305	35144	5.43	0	Cytoplasm;Mitochondrion	NA	Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation (PubMed:29053956).	NA	Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.	COPII-mediated vesicle transport	PE1	9
+NX_O00744	Protein Wnt-10b	389	43000	9.37	0	Golgi apparatus;Extracellular matrix;Secreted	Split-hand/foot malformation 6;Tooth agenesis, selective, 8	Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors);Transcriptional regulation of white adipocyte differentiation	PE1	12
+NX_O00746	Nucleoside diphosphate kinase, mitochondrial	187	20659	10.3	0	Mitochondrion matrix;Mitochondrion intermembrane space;Mitochondrion	NA	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663).	NA	Belongs to the NDK family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	16
+NX_O00748	Cocaine esterase	559	61807	5.71	0	Golgi apparatus;Endoplasmic reticulum;Cytosol;Endoplasmic reticulum lumen	NA	Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).	Glycosylated.	Belongs to the type-B carboxylesterase/lipase family.	Drug metabolism - other enzymes;Phase I - Functionalization of compounds	PE1	16
+NX_O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	1634	184768	6.95	0	Microsome;Cell membrane;Nucleoplasm;Endoplasmic reticulum;Cytosol;Nucleus	NA	Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.	NA	Belongs to the PI3/PI4-kinase family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the plasma membrane	PE1	1
+NX_O00754	Lysosomal alpha-mannosidase	1011	113744	6.84	0	Cytoplasmic vesicle;Nucleoplasm;Lysosome	Mannosidosis, alpha B, lysosomal	Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages.	First processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). The 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked.;Heavily glycosylated.	Belongs to the glycosyl hydrolase 38 family.	Other glycan degradation;Lysosome;Lysosomal oligosaccharide catabolism;Neutrophil degranulation	PE1	19
+NX_O00755	Protein Wnt-7a	349	39005	9.05	0	Extracellular matrix;Secreted	Limb pelvis hypoplasia aplasia syndrome;Fuhrmann syndrome	Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity).	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors)	PE1	3
+NX_O00757	Fructose-1,6-bisphosphatase isozyme 2	339	36743	6.84	0	Cytoplasm;Cell membrane;Cell junction;Nucleoplasm;Z line;Nucleus	NA	Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.	NA	Belongs to the FBPase class 1 family.	Carbohydrate biosynthesis; gluconeogenesis.;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Fructose and mannose metabolism;Metabolic pathways;Insulin signaling pathway;Gluconeogenesis	PE1	9
+NX_O00762	Ubiquitin-conjugating enzyme E2 C	179	19652	6.83	0	Cytosol;Cell membrane	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.	Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination & Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	20
+NX_O00763	Acetyl-CoA carboxylase 2	2458	276541	6.05	0	Endomembrane system;Mitochondrion;Nucleus	NA	Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA (PubMed:20457939, PubMed:19236960, PubMed:20952656). Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (PubMed:20457939, PubMed:19236960, PubMed:20952656). Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).	Phosphorylated by AMPK, leading to inactivation of the enzyme. Required for the maintenance of skeletal muscle lipid and glucose homeostasis (By similarity).	NA	Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.;Fatty acid biosynthesis;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Insulin signaling pathway;Adipocytokine signaling pathway;ChREBP activates metabolic gene expression;Activation of gene expression by SREBF (SREBP);Import of palmitoyl-CoA into the mitochondrial matrix;Biotin transport and metabolism	PE1	12
+NX_O00764	Pyridoxal kinase	312	35102	5.75	0	Nucleoplasm;Cytoplasm	NA	Required for synthesis of pyridoxal-5-phosphate from vitamin B6.	NA	Belongs to the pyridoxine kinase family.	Vitamin B6 metabolism;Metabolic pathways;Vitamins B6 activation to pyridoxal phosphate;Neutrophil degranulation	PE1	21
+NX_O00767	Acyl-CoA desaturase	359	41523	9.07	4	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).	NA	Belongs to the fatty acid desaturase type 1 family.	Biosynthesis of unsaturated fatty acids;PPAR signaling pathway;Activation of gene expression by SREBF (SREBP);Fatty acyl-CoA biosynthesis	PE1	10
+NX_O14490	Disks large-associated protein 1	977	108873	6.66	0	Postsynaptic density;Synapse;Cell membrane	NA	Part of the postsynaptic scaffold in neuronal cells.	NA	Belongs to the SAPAP family.	Glutamatergic synapse;Neurexins and neuroligins	PE1	18
+NX_O14492	SH2B adapter protein 2	632	67738	5.85	0	Cytoplasm;Cytosol;Cell membrane	NA	Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.	Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex.;SH2B2 is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	Belongs to the SH2B adapter family.	Neurotrophin signaling pathway;Insulin signaling pathway;Factors involved in megakaryocyte development and platelet production;Regulation of KIT signaling	PE1	7
+NX_O14493	Claudin-4	209	22077	8.38	4	Tight junction;Cell membrane	NA	Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	7
+NX_O14494	Phospholipid phosphatase 1	284	32156	8.1	6	Cell membrane	NA	Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.	N-glycosylated. Contains high-mannose oligosaccharides.	Belongs to the PA-phosphatase related phosphoesterase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Ether lipid metabolism;Sphingolipid metabolism;Metabolic pathways;Fc gamma R-mediated phagocytosis;Fat digestion and absorption;Sphingolipid de novo biosynthesis	PE1	5
+NX_O14495	Phospholipid phosphatase 3	311	35116	9.31	6	Golgi apparatus;trans-Golgi network membrane;Cell membrane	NA	Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.	N-glycosylated. Contains high-mannose oligosaccharides.	Belongs to the PA-phosphatase related phosphoesterase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Ether lipid metabolism;Sphingolipid metabolism;Metabolic pathways;Fc gamma R-mediated phagocytosis;Fat digestion and absorption;Sphingolipid de novo biosynthesis	PE1	1
+NX_O14497	AT-rich interactive domain-containing protein 1A	2285	242045	6.24	0	Nucleoplasm;Nucleus	Coffin-Siris syndrome 2	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).	NA	NA	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	1
+NX_O14498	Immunoglobulin superfamily containing leucine-rich repeat protein	428	45997	5	0	Golgi apparatus;Secreted;Cell membrane	NA	NA	NA	NA	Platelet degranulation	PE1	15
+NX_O14503	Class E basic helix-loop-helix protein 40	412	45510	8.3	0	Cytoplasm;Nucleus	NA	Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:12397359, PubMed:18411297). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (PubMed:15193144). Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:15560782). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706). Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558). May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (PubMed:19786558). Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-ARNTL/BMAL1 complex (PubMed:28797635). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868).	Sumoylation inhibits its ubiquitination and promotes its negative regulation of the CLOCK-ARNTL/BMAL1 heterodimer transcriptional activator activity.;Ubiquitinated; which may lead to proteasomal degradation.	NA	Circadian rhythm - mammal;BMAL1:CLOCK,NPAS2 activates circadian gene expression	PE1	3
+NX_O14508	Suppressor of cytokine signaling 2	198	22172	8.9	0	Endoplasmic reticulum	NA	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	NA	Protein modification; protein ubiquitination.;Jak-STAT signaling pathway;Insulin signaling pathway;Type II diabetes mellitus;Interleukin-7 signaling;Growth hormone receptor signaling;Neddylation	PE1	12
+NX_O14511	Pro-neuregulin-2, membrane-bound isoform	850	91679	9.51	1	Nucleoplasm;Secreted;Nucleolus;Cell membrane	NA	Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.	Extensive glycosylation precedes the proteolytic cleavage.;Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.	Belongs to the neuregulin family.	ErbB signaling pathway;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;PI3K events in ERBB4 signaling;SHC1 events in ERBB4 signaling;Nuclear signaling by ERBB4;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;GRB7 events in ERBB2 signaling;Downregulation of ERBB2:ERBB3 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling	PE1	5
+NX_O14512	Suppressor of cytokine signaling 7	581	62969	8.35	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).	NA	NA	Protein modification; protein ubiquitination.;Jak-STAT signaling pathway	PE1	17
+NX_O14513	Nck-associated protein 5	1909	208537	8.34	0	Golgi apparatus;Cytosol;Nucleolus;Cell membrane	NA	NA	NA	NA	NA	PE1	2
+NX_O14514	Adhesion G protein-coupled receptor B1	1584	173501	8.27	7	Dendritic spine;Cell membrane;Focal adhesion;Secreted;Phagocytic cup;Postsynaptic density	NA	Vasculostatin-120: Inhibits angiogenesis in a CD36-dependent manner.;Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720).;Vasculostatin-40: Inhibits angiogenesis.	Ubiquitinated.;Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120 (PubMed:15782143, PubMed:22333914, PubMed:22330140). Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327 (PubMed:22330140).	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.	p53 signaling pathway	PE1	8
+NX_O14519	Cyclin-dependent kinase 2-associated protein 1	115	12365	9.41	0	Nucleoplasm	NA	Specific inhibitor of the cell-cycle kinase CDK2.	Phosphorylated in vitro by IKBKE at Ser-46.	Belongs to the CDK2AP family.	NA	PE1	12
+NX_O14520	Aquaporin-7	342	37232	9.04	5	Cytoplasmic vesicle membrane;Cell cortex;Lipid droplet;Cell membrane	NA	Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family.	PPAR signaling pathway;Transport of glycerol from adipocytes to the liver by Aquaporins;Passive transport by Aquaporins	PE1	9
+NX_O14521	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	159	17043	8.92	3	Mitochondrion inner membrane	Pheochromocytoma;Paragangliomas 1;Mitochondrial complex II deficiency;Paraganglioma and gastric stromal sarcoma	Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	NA	Belongs to the CybS family.	Carbohydrate metabolism; tricarboxylic acid cycle.;Citrate cycle (TCA cycle);Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Citric acid cycle (TCA cycle)	PE1	11
+NX_O14522	Receptor-type tyrosine-protein phosphatase T	1441	162134	6.44	1	Membrane	NA	May be involved in both signal transduction and cellular adhesion in the CNS.	NA	Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.	NA	PE1	20
+NX_O14523	Phospholipid transfer protein C2CD2L	706	76181	7.61	1	Endoplasmic reticulum membrane;Cell membrane;Nucleolus;Nucleus membrane;Nucleoplasm;Cytosol	NA	Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843).	Phosphorylation at the C-terminus acidifies the protein and leads to disassociation from the acidic cell membrane. Reassociates with the cell membrane upon dephosphorylation.	NA	NA	PE1	11
+NX_O14524	Nuclear envelope integral membrane protein 1	444	50640	6.56	5	Nucleus inner membrane;Nucleoplasm;Nucleus envelope	NA	NA	Phosphorylation may regulate its interaction with RAN-GTP.	Belongs to the NEMP family.	NA	PE1	12
+NX_O14525	Astrotactin-1	1302	144913	5.09	2	Clathrin-coated vesicle;Golgi apparatus;Cell membrane;Perikaryon;Endosome;Cytoplasmic vesicle	NA	Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.	NA	Belongs to the astrotactin family.	NA	PE1	1
+NX_O14526	F-BAR domain only protein 1	889	96861	6.51	0	Nucleoplasm;Cytosol;Clathrin-coated pit	NA	Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.	NA	Belongs to the FCHO family.	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	19
+NX_O14529	Homeobox protein cut-like 2	1486	161677	5.38	0	Nucleus	Epileptic encephalopathy, early infantile, 67	Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner.	NA	Belongs to the CUT homeobox family.	NA	PE1	12
+NX_O14530	Thioredoxin domain-containing protein 9	226	26534	5.61	0	Cytoplasm;Nucleus;Centrosome;Cytosol;Midbody	NA	Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.	NA	NA	NA	PE1	2
+NX_O14531	Dihydropyrimidinase-related protein 4	572	61878	6.64	0	Cytoplasmic vesicle;Cytoplasm;Mitochondrion	NA	Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).	NA	Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.	CRMPs in Sema3A signaling	PE1	10
+NX_O14543	Suppressor of cytokine signaling 3	225	24770	8.97	0	Cytosol;Cell membrane	NA	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).	Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1.;SOCS3 is phosphorylated by IGF1R (Phosphotyrosine:PTM-0255);SOCS3 is phosphorylated by PIM1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Osteoclast differentiation;Jak-STAT signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Type II diabetes mellitus;Hepatitis C;Influenza A;Herpes simplex infection;Antigen processing: Ubiquitination & Proteasome degradation;Interferon gamma signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling;Growth hormone receptor signaling;Regulation of IFNG signaling;Interleukin-6 signaling;Signaling by Leptin;PTK6 Activates STAT3;Interleukin-4 and Interleukin-13 signaling;Neddylation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	PE1	17
+NX_O14544	Suppressor of cytokine signaling 6	535	59528	6.79	0	Cytosol;Nucleus speckle	NA	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.	SOCS6 is phosphorylated by PIM3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Protein modification; protein ubiquitination.;Regulation of KIT signaling;Neddylation	PE1	18
+NX_O14545	TRAF-type zinc finger domain-containing protein 1	582	64841	5.19	0	Nucleoplasm;Cytosol	NA	Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).	NA	NA	NA	PE1	12
+NX_O14548	Cytochrome c oxidase subunit 7A-related protein, mitochondrial	114	12615	9.43	0	Mitochondrion inner membrane;Mitochondrion;Nucleolus	NA	Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).	NA	Belongs to the cytochrome c oxidase VIIa family.	Oxidative phosphorylation;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	2
+NX_O14556	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	408	44501	8.39	0	Cytoplasm;Nucleoplasm;Centrosome	NA	May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).	NA	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.;Glycolysis / Gluconeogenesis;Metabolic pathways;Glycolysis;Association of TriC/CCT with target proteins during biosynthesis;Gluconeogenesis	PE1	19
+NX_O14558	Heat shock protein beta-6	160	17136	5.95	0	Golgi apparatus;Cytoplasm;Secreted;Nucleolus;Cytosol;Nucleus	NA	Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.	Phosphorylated at Ser-16 by PKA and probably PKD1K; required to protect cardiomyocytes from apoptosis.;The N-terminus is blocked.	Belongs to the small heat shock protein (HSP20) family.	NA	PE1	19
+NX_O14559	Rho GTPase-activating protein 33	1287	137213	9.05	0	Cytosol;Cytoskeleton;Cell membrane	NA	May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity).	ARHGAP33 is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the PX domain-containing GAP family.	Rho GTPase cycle	PE1	19
+NX_O14561	Acyl carrier protein, mitochondrial	156	17417	4.82	0	Nucleoplasm;Mitochondrion	NA	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371).	NA	Belongs to the acyl carrier protein (ACP) family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Glyoxylate metabolism and glycine degradation;Mitochondrial Fatty Acid Beta-Oxidation;Complex I biogenesis	PE1	16
+NX_O14562	Ubiquitin domain-containing protein UBFD1	309	33382	5.55	0	Nucleoplasm;Nucleolus	NA	May play a role as NF-kappa-B regulator.	NA	NA	NA	PE1	16
+NX_O14569	Cytochrome b561 domain-containing protein 2	222	23974	9.93	6	Cytoplasmic vesicle membrane;Endoplasmic reticulum membrane	NA	Two-heme-containing cytochrome that catalyzes ascorbate-dependent trans-membrane ferric-chelate reduction.	NA	NA	NA	PE1	3
+NX_O14576	Cytoplasmic dynein 1 intermediate chain 1	645	72955	5	0	Cytoplasm;Spindle pole;Kinetochore	NA	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.	NA	Belongs to the dynein intermediate chain family.	Phagosome;Vasopressin-regulated water reabsorption;Salmonella infection;Separation of Sister Chromatids;MHC class II antigen presentation;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	7
+NX_O14578	Citron Rho-interacting kinase	2027	231431	6.16	0	Cytoplasm;Cytosol	Microcephaly 17, primary, autosomal recessive	Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	RHO GTPases activate CIT	PE1	12
+NX_O14579	Coatomer subunit epsilon	308	34482	4.98	0	Golgi apparatus;Cytoplasm;COPI-coated vesicle membrane;Golgi apparatus membrane	NA	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).	Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation.;Phosphorylated by PKA.	Belongs to the COPE family.	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	19
+NX_O14581	Olfactory receptor 7A17	309	34013	6.48	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_O14593	DNA-binding protein RFXANK	260	28102	4.45	0	Cytoplasm;Nucleoplasm;Nucleus	Bare lymphocyte syndrome 2	Is not involved in the positive regulation of MHC class II genes.;Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724). May also potentiate the activation of RAF1 (By similarity).	Phosphorylated by RAF1.	NA	Antigen processing and presentation;Tuberculosis;Primary immunodeficiency	PE1	19
+NX_O14594	Neurocan core protein	1321	143093	5.22	0	Secreted	NA	May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.	O-glycosylated.	Belongs to the aggrecan/versican proteoglycan family.	Chondroitin sulfate biosynthesis;NCAM1 interactions;A tetrasaccharide linker sequence is required for GAG synthesis;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;ECM proteoglycans;Dermatan sulfate biosynthesis;L1CAM interactions;CS/DS degradation;Defective CHST3 causes SEDCJD;Defective CHST14 causes EDS, musculocontractural type;Defective CHSY1 causes TPBS;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	19
+NX_O14595	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2	271	30664	5.34	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.	NA	NA	XBP1(S) activates chaperone genes	PE1	12
+NX_O14598	Testis-specific basic protein Y 1	125	12917	9.43	0	NA	NA	May mediate a process in spermatogenesis or may play a role in sex ratio distortion.	NA	Belongs to the VCX/VCY family.	NA	PE1	Y
+NX_O14599	Testis-specific basic protein Y 2	106	12063	10.19	0	NA	NA	NA	NA	Belongs to the VCX/VCY family.	NA	PE1	Y
+NX_O14602	Eukaryotic translation initiation factor 1A, Y-chromosomal	144	16442	5.07	0	NA	NA	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).	NA	Belongs to the eIF-1A family.	RNA transport	PE1	Y
+NX_O14603	PTPN13-like protein, Y-linked	147	16512	8.27	0	NA	NA	NA	NA	NA	NA	PE1	Y
+NX_O14604	Thymosin beta-4, Y-chromosomal	44	5013	5.34	0	Cytoskeleton	NA	Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).	NA	Belongs to the thymosin beta family.	Regulation of actin cytoskeleton	PE1	Y
+NX_O14607	Histone demethylase UTY	1347	149548	7.91	0	Nucleus	NA	Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.	NA	Belongs to the UTX family.	HDMs demethylate histones	PE1	Y
+NX_O14609	Testis-specific XK-related protein, Y-linked	159	18083	6.56	3	Membrane	NA	NA	NA	Belongs to the XK family.	NA	PE2	Y
+NX_O14610	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	69	7747	6.27	0	Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the G protein gamma family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	17
+NX_O14613	Cdc42 effector protein 2	210	22484	4.94	0	Cytosol;Endomembrane system;Cytoskeleton	NA	Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.	NA	Belongs to the BORG/CEP family.	MAPK6/MAPK4 signaling	PE1	11
+NX_O14617	AP-3 complex subunit delta-1	1153	130158	8.69	0	Cytoplasm;Cytosol;Golgi apparatus membrane	Hermansky-Pudlak syndrome 10	Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).	NA	Belongs to the adaptor complexes large subunit family.	Lysosome	PE1	19
+NX_O14618	Copper chaperone for superoxide dismutase	274	29041	5.32	0	Cytoplasm	NA	Delivers copper to copper zinc superoxide dismutase (SOD1).	Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241.	In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.	Amyotrophic lateral sclerosis (ALS);Detoxification of Reactive Oxygen Species	PE1	11
+NX_O14625	C-X-C motif chemokine 11	94	10365	9.94	0	Secreted	NA	Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.	NA	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Toll-like receptor signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	4
+NX_O14626	Probable G-protein coupled receptor 171	319	36754	9.1	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	3
+NX_O14627	Homeobox protein CDX-4	284	30480	9.03	0	Nucleus	NA	NA	NA	Belongs to the Caudal homeobox family.	NA	PE1	X
+NX_O14628	Zinc finger protein 195	629	72332	8.45	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	11
+NX_O14633	Late cornified envelope protein 2B	110	11219	8.54	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_O14638	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	875	100124	6.12	1	Apical cell membrane;Secreted;Cell membrane	NA	Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity (PubMed:11342463).	N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal.	Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.	Purine metabolism;Starch and sucrose metabolism;Riboflavin metabolism;Nicotinate and nicotinamide metabolism;Pantothenate and CoA biosynthesis;Metabolic pathways;Vitamin B5 (pantothenate) metabolism	PE1	6
+NX_O14639	Actin-binding LIM protein 1	778	87688	8.91	0	Cytoplasm;Cytosol;Cytoskeleton	NA	May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.	ABLIM1 is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Axon guidance;DCC mediated attractive signaling	PE1	10
+NX_O14640	Segment polarity protein dishevelled homolog DVL-1	695	75187	7.69	0	Cytoplasmic vesicle;Cytosol;Cell membrane	Robinow syndrome, autosomal dominant 2	Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).	Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity).	Belongs to the DSH family.	Wnt signaling pathway;Notch signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Degradation of DVL;RHO GTPases Activate Formins;TCF dependent signaling in response to WNT;PCP/CE pathway;Disassembly of the destruction complex and recruitment of AXIN to the membrane;WNT mediated activation of DVL;Negative regulation of TCF-dependent signaling by DVL-interacting proteins	PE1	1
+NX_O14641	Segment polarity protein dishevelled homolog DVL-2	736	78948	5.67	0	Cell membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.	Phosphorylated by CSNK1D (PubMed:21422228, PubMed:9192851). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (PubMed:25805136).	Belongs to the DSH family.	Wnt signaling pathway;Notch signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Asymmetric localization of PCP proteins;Degradation of DVL;Signaling by Hippo;RHO GTPases Activate Formins;TCF dependent signaling in response to WNT;PCP/CE pathway;WNT5A-dependent internalization of FZD4;Disassembly of the destruction complex and recruitment of AXIN to the membrane;WNT mediated activation of DVL;Negative regulation of TCF-dependent signaling by DVL-interacting proteins;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	17
+NX_O14645	Axonemal dynein light intermediate polypeptide 1	258	29662	8.73	0	Cilium	NA	May play a dynamic role in flagellar motility.	NA	Belongs to the inner dynein arm light chain family.	Huntington's disease	PE1	1
+NX_O14646	Chromodomain-helicase-DNA-binding protein 1	1710	196688	6.68	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	Pilarowski-Bjornsson syndrome	ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity).	NA	Belongs to the SNF2/RAD54 helicase family.	Estrogen-dependent gene expression	PE1	5
+NX_O14647	Chromodomain-helicase-DNA-binding protein 2	1828	211344	8.22	0	Nucleoplasm;Nucleus	Epileptic encephalopathy, childhood-onset	DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).	NA	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	15
+NX_O14649	Potassium channel subfamily K member 3	394	43518	9.26	4	Cell membrane	Pulmonary hypertension, primary, 4	PH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.	NA	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	TWIK-releated acid-sensitive K+ channel (TASK);Phase 4 - resting membrane potential	PE1	2
+NX_O14653	Golgi SNAP receptor complex member 2	212	24775	7.86	1	Golgi apparatus;Endoplasmic reticulum membrane;cis-Golgi network membrane;Nucleoplasm;Golgi apparatus membrane	Epilepsy, progressive myoclonic 6	Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.	NA	Belongs to the GOSR2 family.	SNARE interactions in vesicular transport;XBP1(S) activates chaperone genes;COPII-mediated vesicle transport;Cargo concentration in the ER;Intra-Golgi traffic;COPI-mediated anterograde transport	PE1	17
+NX_O14654	Insulin receptor substrate 4	1257	133768	8.72	0	Cell membrane	NA	Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.	Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-921 in response to FGF2 signaling. Phosphorylation of Tyr-921 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction.	NA	Neurotrophin signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;IRS-related events triggered by IGF1R	PE1	X
+NX_O14656	Torsin-1A	332	37809	6.51	0	Growth cone;Nucleus membrane;Cytoplasmic vesicle membrane;Cytoplasmic vesicle;Endoplasmic reticulum lumen;Synaptic vesicle;Secretory vesicle;Cytoskeleton	Dystonia 1, torsion, autosomal dominant	Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.	N-glycosylated.	Belongs to the ClpA/ClpB family. Torsin subfamily.	Cargo recognition for clathrin-mediated endocytosis	PE1	9
+NX_O14657	Torsin-1B	336	37979	8.76	0	Cytosol;Endoplasmic reticulum lumen;Nucleus speckle;Nucleus membrane	NA	May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues.	N-glycosylated.	Belongs to the ClpA/ClpB family. Torsin subfamily.	Cargo recognition for clathrin-mediated endocytosis	PE1	9
+NX_O14662	Syntaxin-16	325	37031	5.75	1	Cytoplasmic vesicle;Cytoplasm;Golgi apparatus membrane	Pseudohypoparathyroidism 1B	SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.	NA	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network	PE1	20
+NX_O14668	Transmembrane gamma-carboxyglutamic acid protein 1	218	24947	5.13	1	Cytoplasmic vesicle;Nucleoplasm;Membrane;Cell membrane	NA	NA	Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.	NA	NA	PE1	X
+NX_O14669	Transmembrane gamma-carboxyglutamic acid protein 2	202	22393	5.22	1	Membrane;Nucleoplasm;Cytosol;Nucleolus	NA	NA	Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.	NA	NA	PE1	19
+NX_O14672	Disintegrin and metalloproteinase domain-containing protein 10	748	84142	8.04	1	Cytoplasm;Clathrin-coated vesicle;Cell membrane;Adherens junction;Nucleoplasm;Golgi apparatus membrane;Cytoplasmic vesicle;Axon;Dendrite	Alzheimer disease 18;Reticulate acropigmentation of Kitamura	Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905, PubMed:29224781). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:24990881). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146).;(Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores.	The precursor is cleaved by furin and PCSK7.	NA	Alzheimer's disease;Epithelial cell signaling in Helicobacter pylori infection;Degradation of the extracellular matrix;EPH-ephrin mediated repulsion of cells;Amyloid fiber formation;Collagen degradation;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Activated NOTCH1 Transmits Signal to the Nucleus;Signaling by EGFR;Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Neutrophil degranulation;Post-translational protein phosphorylation;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus	PE1	15
+NX_O14678	ATP-binding cassette sub-family D member 4	606	68597	6.12	5	Peroxisome membrane	Methylmalonic aciduria and homocystinuria type cblJ	May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.	NA	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.	ABC transporters;Peroxisome;Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective ABCD4 causes methylmalonic aciduria and homocystinuria, cblj type (MAHCJ)	PE1	14
+NX_O14681	Etoposide-induced protein 2.4 homolog	340	38965	9.75	5	Golgi apparatus;Cytoplasm;Endoplasmic reticulum membrane;Nucleus membrane;Endoplasmic reticulum;Cytosol	NA	Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity).	NA	Belongs to the EI24 family.	p53 signaling pathway	PE1	11
+NX_O14682	Ectoderm-neural cortex protein 1	589	66130	6.4	0	Cytoplasm;Nucleus matrix;Cell membrane;Cytoskeleton	NA	Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.	Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination.	NA	NA	PE1	5
+NX_O14683	Tumor protein p53-inducible protein 11	189	21054	9.57	4	Membrane;Golgi apparatus;Endoplasmic reticulum	NA	NA	NA	NA	NA	PE1	11
+NX_O14684	Prostaglandin E synthase	152	17102	9.59	4	Membrane;Endoplasmic reticulum	NA	Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).	NA	Belongs to the MAPEG family.	Arachidonic acid metabolism;Metabolic pathways;Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	PE1	9
+NX_O14686	Histone-lysine N-methyltransferase 2D	5537	593389	5.4	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	Kabuki syndrome 1	Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	Lysine degradation;PKMTs methylate histone lysines;Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	12
+NX_O14709	Zinc finger protein 197	1029	118847	8.91	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	3
+NX_O14713	Integrin beta-1-binding protein 1	200	21782	5.95	0	Cytoplasm;Cell membrane;Centriolar satellite;Nucleoplasm;Lamellipodium;Ruffle;Cytosol;Nucleus;Cytoskeleton	NA	Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.	Phosphorylation at Thr-38 seems to enhance integrin alpha5beta1-mediated cell adhesion. The degree of phosphorylation is regulated by integrin-dependent cell-matrix interaction.	NA	NA	PE1	2
+NX_O14715	RANBP2-like and GRIP domain-containing protein 8	1765	198993	6.09	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_O14717	tRNA (cytosine(38)-C(5))-methyltransferase	391	44597	5.78	0	Nucleoplasm;Cytoplasm;Centrosome;Nucleolus	NA	Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	tRNA modification in the nucleus and cytosol	PE1	10
+NX_O14718	Visual pigment-like receptor peropsin	337	37423	8.78	7	Membrane	NA	May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.	NA	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	G alpha (i) signalling events;Opsins	PE1	4
+NX_O14727	Apoptotic protease-activating factor 1	1248	141840	5.96	0	Nucleoplasm;Cytoplasm;Cytosol;Golgi apparatus	NA	Is less effective in inducing apoptosis.;Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	NA	NA	p53 signaling pathway;Apoptosis;Alzheimer's disease;Parkinson's disease;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Legionellosis;Tuberculosis;Small cell lung cancer;Formation of apoptosome;Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes;TP53 Regulates Transcription of Caspase Activators and Caspases;Neutrophil degranulation;Transcriptional Regulation by E2F6;Regulation of the apoptosome activity	PE1	12
+NX_O14730	Serine/threonine-protein kinase RIO3	519	59093	5.52	0	Golgi apparatus;Cytoplasm;Cell membrane;Centriolar satellite;Cytosol	NA	Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).	Autophosphorylated (in vitro).	Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	18
+NX_O14732	Inositol monophosphatase 2	288	31321	6.15	0	Nucleoplasm;Mitochondrion	NA	Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.	NA	Belongs to the inositol monophosphatase superfamily.	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.;Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of IP2, IP, and Ins in the cytosol	PE1	18
+NX_O14733	Dual specificity mitogen-activated protein kinase kinase 7	419	47485	9.26	0	Golgi apparatus;Cytoplasm;Cell membrane;Cytosol;Nucleus	NA	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074).	Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks).;MAP2K7 is phosphorylated by MAP3K20 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K7 is phosphorylated by MAP3K3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K7 is phosphorylated by MAP3K12 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K7 is phosphorylated by MAP3K5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K7 is phosphorylated by MAP3K11 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	MAPK signaling pathway;ErbB signaling pathway;Protein processing in endoplasmic reticulum;Osteoclast differentiation;Toll-like receptor signaling pathway;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Neurotrophin signaling pathway;GnRH signaling pathway;Influenza A;Oxidative Stress Induced Senescence;Uptake and function of anthrax toxins;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	PE1	19
+NX_O14734	Acyl-coenzyme A thioesterase 8	319	35914	7.22	0	Cytoplasmic vesicle;Mitochondrion;Peroxisome matrix	NA	(Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233).;Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431). Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:9299485, PubMed:9153233). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). ACOT8 is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431).	NA	Belongs to the C/M/P thioester hydrolase family.	Lipid metabolism; fatty acid metabolism.;Peroxisome;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Beta-oxidation of pristanoyl-CoA;alpha-linolenic acid (ALA) metabolism;Beta-oxidation of very long chain fatty acids;Peroxisomal protein import	PE1	20
+NX_O14735	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	213	23539	8.23	5	Endoplasmic reticulum membrane;Cell membrane;Nucleus membrane;Membrane;Nucleoplasm;Golgi apparatus membrane	NA	Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.	NA	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Inositol phosphate metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PI	PE1	16
+NX_O14737	Programmed cell death protein 5	125	14285	5.77	0	Nucleoplasm;Cytosol	NA	May function in the process of apoptosis.	NA	Belongs to the PDCD5 family.	NA	PE1	19
+NX_O14744	Protein arginine N-methyltransferase 5	637	72684	5.88	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol;Nucleus	NA	Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951, PubMed:21081503). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates TP53; methylation might possibly affect TP53 target gene specificity (PubMed:19011621).	PRMT5 is phosphorylated by JAK2	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	RNA transport;RMTs methylate histone arginines;snRNP Assembly;Regulation of TP53 Activity through Methylation	PE1	14
+NX_O14745	Na(+)/H(+) exchange regulatory cofactor NHE-RF1	358	38868	5.55	0	Cytoplasm;Cell membrane;Endomembrane system;Centriolar satellite;Filopodium;Ruffle;Cytoplasmic vesicle;Apical cell membrane;Microvillus	Nephrolithiasis/osteoporosis, hypophosphatemic, 2	Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.	Phosphorylated on serine residues.	NA	NA	PE1	17
+NX_O14746	Telomerase reverse transcriptase	1132	126997	10.54	0	Cytoplasm;Nucleus speckle;Nucleolus;Nucleoplasm;Telomere;PML body;Cytosol;Nucleus	Dyskeratosis congenita, autosomal dominant, 2;Melanoma, cutaneous malignant 9;Aplastic anemia;Pulmonary fibrosis, idiopathic;Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 1;Dyskeratosis congenita, autosomal recessive, 4	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.	Ubiquitinated by the EDVP complex, a E3 ligase complex following phosphorylation at Ser-457 by DYRK2. Ubiquitinated leads to proteasomal degradation.;Phosphorylation at Tyr-707 under oxidative stress leads to translocation of TERT to the cytoplasm and reduces its antiapoptotic activity. Dephosphorylated by SHP2/PTPN11 leading to nuclear retention. Phosphorylation at Ser-227 by the AKT pathway promotes nuclear location. Phosphorylation at the G2/M phase at Ser-457 by DYRK2 promotes ubiquitination by the EDVP complex and degradation.;(Microbial infection) In case of infection by HIV-1, the EDVP complex is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP, leading to ubiquitination and degradation.;TERT is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	Belongs to the reverse transcriptase family. Telomerase subfamily.	HTLV-I infection;Formation of the beta-catenin:TCF transactivating complex;Telomere Extension By Telomerase	PE1	5
+NX_O14753	Putative transcription factor Ovo-like 1	267	30259	9.02	0	Nucleoplasm;Nucleus	NA	Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).	NA	NA	NA	PE1	11
+NX_O14756	17-beta-hydroxysteroid dehydrogenase type 6	317	35966	8.94	0	Early endosome membrane;Nucleoplasm;Microsome membrane;Cytoplasmic vesicle	NA	NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Steroid hormone biosynthesis;Metabolic pathways;The canonical retinoid cycle in rods (twilight vision)	PE1	12
+NX_O14757	Serine/threonine-protein kinase Chk1	476	54434	8.5	0	Cytoplasm;Nucleoplasm;Centrosome;Cytoplasmic vesicle;Nucleus	NA	Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition.;Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA. May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes. May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest.	Ubiquitinated. Mono or diubiquitination promotes nuclear exclusion (By similarity). The activated form (phosphorylated on Ser-345) is polyubiquitinated at Lys-436 by some SCF-type E3 ubiquitin ligase complex containing FBXO6 promoting its degradation. Ubiquitination and degradation are required to terminate the checkpoint and ensure that activated CHEK1 does not accumulate as cells progress through S phase, when replication forks encounter transient impediments during normal DNA replication.;Phosphorylated by ATR in a RAD17-dependent manner in response to ultraviolet irradiation and inhibition of DNA replication. Phosphorylated by ATM in response to ionizing irradiation. ATM and ATR can both phosphorylate Ser-317 and Ser-345 and this results in enhanced kinase activity. Phosphorylation at Ser-345 induces a change in the conformation of the protein, activates the kinase activity and is a prerequisite for interaction with FBXO6 and subsequent ubiquitination at Lys-436. Phosphorylation at Ser-345 also increases binding to 14-3-3 proteins and promotes nuclear retention. Conversely, dephosphorylation at Ser-345 by PPM1D may contribute to exit from checkpoint mediated cell cycle arrest. Phosphorylation at Ser-280 by AKT1/PKB, may promote mono and/or diubiquitination. Also phosphorylated at undefined residues during mitotic arrest, resulting in decreased activity.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.	Cell cycle;p53 signaling pathway;HTLV-I infection;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;Signaling by SCF-KIT;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;Transcriptional Regulation by E2F6	PE1	11
+NX_O14763	Tumor necrosis factor receptor superfamily member 10B	440	47878	5.39	1	Membrane	Squamous cell carcinoma of the head and neck	Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.	NA	NA	Cytokine-cytokine receptor interaction;p53 signaling pathway;Apoptosis;Natural killer cell mediated cytotoxicity;Measles;Influenza A;Cell surface interactions at the vascular wall;Caspase activation via Death Receptors in the presence of ligand;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TRAIL signaling;TP53 Regulates Transcription of Death Receptors and Ligands	PE1	8
+NX_O14764	Gamma-aminobutyric acid receptor subunit delta	452	50708	8.7	4	Cytoplasmic vesicle;Golgi apparatus;Cell membrane;Postsynaptic cell membrane	Generalized epilepsy with febrile seizures plus 5;Epilepsy, idiopathic generalized 10;Juvenile myoclonic epilepsy 7	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse	PE1	1
+NX_O14770	Homeobox protein Meis2	477	51790	5.92	0	Nucleoplasm;Cytosol;Perinuclear region;Nucleus	Cleft palate, cardiac defects, and mental retardation	Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex.;Is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4.;Can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.	NA	Belongs to the TALE/MEIS homeobox family.	NA	PE1	15
+NX_O14771	Zinc finger protein 213	459	51263	6.48	0	Nucleus membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_O14772	Fucose-1-phosphate guanylyltransferase	607	68010	6.45	0	Cytoplasm	NA	Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.	NA	NA	Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;GDP-fucose biosynthesis	PE1	1
+NX_O14773	Tripeptidyl-peptidase 1	563	61248	6.01	0	Cytoplasm;Melanosome;Lysosome	Spinocerebellar ataxia, autosomal recessive, 7;Ceroid lipofuscinosis, neuronal, 2	Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:11054422, PubMed:19038966, PubMed:19038967). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (PubMed:11054422, PubMed:19038966, PubMed:19038967). Requires substrates with an unsubstituted N-terminus (PubMed:19038966).	Activated by autocatalytic proteolytical processing upon acidification (PubMed:11054422, PubMed:19038966, PubMed:19038967). N-glycosylation is required for processing and activity (PubMed:19038966, PubMed:19038967).	NA	Lysosome;XBP1(S) activates chaperone genes	PE1	11
+NX_O14775	Guanine nucleotide-binding protein subunit beta-5	395	43566	6.02	0	Cytoplasm;Nucleus speckle;Membrane;Centrosome;Nucleus	Intellectual developmental disorder with cardiac arrhythmia;Language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia	Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).	NA	Belongs to the WD repeat G protein beta family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Inactivation, recovery and regulation of the phototransduction cascade;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	15
+NX_O14776	Transcription elongation regulator 1	1098	123901	8.71	0	Nucleoplasm;Nucleus	NA	Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.	NA	NA	NA	PE1	5
+NX_O14777	Kinetochore protein NDC80 homolog	642	73913	5.48	0	Nucleoplasm;Nucleus;Centrosome;Kinetochore	NA	Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108).	Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.	Belongs to the NDC80/HEC1 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	18
+NX_O14782	Kinesin-like protein KIF3C	793	89426	8.28	0	Nucleus;Nucleus membrane;Cytoskeleton	NA	Microtubule-based anterograde translocator for membranous organelles.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.	MHC class II antigen presentation;Intraflagellar transport;Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	2
+NX_O14786	Neuropilin-1	923	103134	5.58	1	Endoplasmic reticulum;Secreted;Cell membrane	NA	The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.;The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).	NA	Belongs to the neuropilin family.	Axon guidance;HTLV-I infection;Signal transduction by L1;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Sema3A PAK dependent Axon repulsion;CRMPs in Sema3A signaling;CHL1 interactions;Signaling by ROBO receptors;Neurophilin interactions with VEGF and VEGFR	PE1	10
+NX_O14787	Transportin-2	897	101388	4.87	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).	NA	Belongs to the importin beta family. Importin beta-2 subfamily.	NA	PE1	19
+NX_O14788	Tumor necrosis factor ligand superfamily member 11	317	35478	7.25	1	Cytoplasm;Secreted;Cell membrane	Osteopetrosis, autosomal recessive 2	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).	The soluble form of isoform 1 derives from the membrane form by proteolytic processing (By similarity). The cleavage may be catalyzed by ADAM17.	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;Osteoclast differentiation;Rheumatoid arthritis;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;TNFs bind their physiological receptors	PE1	13
+NX_O14791	Apolipoprotein L1	398	43974	5.6	0	Secreted	Focal segmental glomerulosclerosis 4	May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.	Phosphorylated by FAM20C in the extracellular medium.	Belongs to the apolipoprotein L family.	African trypanosomiasis;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Scavenging of heme from plasma;Post-translational protein phosphorylation	PE1	22
+NX_O14792	Heparan sulfate glucosamine 3-O-sulfotransferase 1	307	35773	8.91	0	Cytoplasmic vesicle;Golgi apparatus lumen	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.	NA	Belongs to the sulfotransferase 1 family.	Glycosaminoglycan biosynthesis - heparan sulfate;HS-GAG biosynthesis	PE1	4
+NX_O14793	Growth/differentiation factor 8	375	42750	6.35	0	Secreted	Muscle hypertrophy	Acts specifically as a negative regulator of skeletal muscle growth.	Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.	Belongs to the TGF-beta family.	FOXO-mediated transcription of cell cycle genes	PE1	2
+NX_O14795	Protein unc-13 homolog B	1591	180679	5.67	0	Golgi apparatus;Cytoplasm;Cell membrane;Membrane;Nucleoplasm;Synapse;Cytoplasmic vesicle;Cytoskeleton	NA	Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).	NA	Belongs to the unc-13 family.	Synaptic vesicle cycle;Acetylcholine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle	PE1	9
+NX_O14796	SH2 domain-containing protein 1B	132	15297	8.97	0	NA	NA	Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).	NA	NA	Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	1
+NX_O14798	Tumor necrosis factor receptor superfamily member 10C	259	27407	4.79	0	Cell membrane	NA	Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.	N-glycosylated and O-glycosylated.	NA	Cytokine-cytokine receptor interaction;Apoptosis;Natural killer cell mediated cytotoxicity;Measles;Influenza A;TP53 Regulates Transcription of Death Receptors and Ligands	PE1	8
+NX_O14802	DNA-directed RNA polymerase III subunit RPC1	1390	155641	8.76	0	Nucleoplasm;Nucleus	Wiedemann-Rautenstrauch syndrome;Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.	NA	Belongs to the RNA polymerase beta' chain family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	10
+NX_O14804	Trace amine-associated receptor 5	337	38242	8.49	7	Cell membrane	NA	Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Amine ligand-binding receptors	PE2	6
+NX_O14807	Ras-related protein M-Ras	208	23846	8.82	0	Cytosol;Cell membrane	NA	May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.	NA	Belongs to the small GTPase superfamily. Ras family.	MAPK signaling pathway;Tight junction;Regulation of actin cytoskeleton;HTLV-I infection	PE1	3
+NX_O14810	Complexin-1	134	15030	4.93	0	Presynapse;Perikaryon;Cytosol	Epileptic encephalopathy, early infantile, 63	Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.	NA	Belongs to the complexin/synaphin family.	Synaptic vesicle cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle	PE1	4
+NX_O14813	Paired mesoderm homeobox protein 2A	284	29653	8.98	0	Nucleus membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	Fibrosis of extraocular muscles, congenital, 2	May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.	NA	Belongs to the paired homeobox family.	NA	PE1	11
+NX_O14815	Calpain-9	690	79097	5.37	0	NA	NA	Calcium-regulated non-lysosomal thiol-protease.	NA	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	1
+NX_O14817	Tetraspanin-4	238	26118	6.07	4	Membrane	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	11
+NX_O14818	Proteasome subunit alpha type-7	248	27887	8.6	0	Cytoplasm;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.	Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks.	Belongs to the peptidase T1A family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination & Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	20
+NX_O14827	Ras-specific guanine nucleotide-releasing factor 2	1237	140764	7.37	0	Endoplasmic reticulum;Cytoplasm;Endoplasmic reticulum membrane;Cell membrane	NA	Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.	Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome (By similarity).;Phosphorylated by CDK5; down-regulates RASGRF2-mediated RAC1 activation.	NA	MAPK signaling pathway;RAF/MAP kinase cascade;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;Ras activation upon Ca2+ influx through NMDA receptor	PE1	5
+NX_O14828	Secretory carrier-associated membrane protein 3	347	38287	7.55	4	Membrane;Cytoplasmic vesicle	NA	Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.	Monoubiquitinated.;SCAMP3 is phosphorylated by EGFR (Phosphotyrosine:PTM-0255)	Belongs to the SCAMP family.	NA	PE1	1
+NX_O14829	Serine/threonine-protein phosphatase with EF-hands 1	653	75792	6.37	0	Cell membrane;Cytoskeleton	NA	May have a role in the recovery or adaptation response of photoreceptors. May have a role in development.	NA	Belongs to the PPP phosphatase family.	Inactivation, recovery and regulation of the phototransduction cascade	PE1	X
+NX_O14830	Serine/threonine-protein phosphatase with EF-hands 2	753	86518	6.7	0	Photoreceptor inner segment;Cytoplasm;Photoreceptor outer segment	NA	May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.	NA	Belongs to the PPP phosphatase family.	NA	PE1	4
+NX_O14832	Phytanoyl-CoA dioxygenase, peroxisomal	338	38538	8.71	0	Peroxisome	Refsum disease	Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.	NA	Belongs to the PhyH family.	Lipid metabolism; fatty acid metabolism.;Peroxisome;Alpha-oxidation of phytanate;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins	PE1	10
+NX_O14836	Tumor necrosis factor receptor superfamily member 13B	293	31816	8.35	1	Membrane	Immunoglobulin A deficiency 2;Immunodeficiency, common variable, 2	Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.	NA	NA	Cytokine-cytokine receptor interaction;Intestinal immune network for IgA production;Primary immunodeficiency;TNFs bind their physiological receptors	PE1	17
+NX_O14841	5-oxoprolinase	1288	137457	6.12	0	Nucleolus	5-oxoprolinase deficiency	Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.	NA	Belongs to the oxoprolinase family.	Glutathione metabolism;Glutathione synthesis and recycling;Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)	PE1	8
+NX_O14842	Free fatty acid receptor 1	300	31457	9.63	7	Cell membrane	NA	G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (q) signalling events;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);Free fatty acid receptors;Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	PE1	19
+NX_O14843	Free fatty acid receptor 3	346	38649	8	7	Cell membrane	NA	G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604).	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (q) signalling events;Free fatty acid receptors	PE1	19
+NX_O14862	Interferon-inducible protein AIM2	343	38954	9.79	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	NA	Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.	NA	Belongs to the HIN-200 family.	Cytosolic DNA-sensing pathway;The AIM2 inflammasome	PE1	1
+NX_O14863	Zinc transporter 4	429	47483	6.11	6	Lysosome membrane;Late endosome membrane;Endosome membrane	NA	Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.	NA	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.	NA	PE1	15
+NX_O14867	Transcription regulator protein BACH1	736	81958	4.95	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).	Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome.	Belongs to the bZIP family. CNC subfamily.	NA	PE1	21
+NX_O14874	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	412	46360	8.97	0	Mitochondrion matrix;Mitochondrion	Branched-chain ketoacid dehydrogenase kinase deficiency	Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.	Autophosphorylated.	Belongs to the PDK/BCKDK protein kinase family.	Branched-chain amino acid catabolism	PE1	16
+NX_O14879	Interferon-induced protein with tetratricopeptide repeats 3	490	55985	5.12	0	Cytoplasm;Cytosol;Mitochondrion	NA	IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.	NA	Belongs to the IFIT family.	Interferon alpha/beta signaling	PE1	10
+NX_O14880	Microsomal glutathione S-transferase 3	152	16516	9.46	3	Membrane;Microsome membrane;Endoplasmic reticulum membrane	NA	Catalyzes oxydation of hydroxy-fatty acids (PubMed:9278457). Also catalyzes the conjugation of a reduced glutathione to leukotriene A4 in vitro (PubMed:9278457). May participate to the lipid metabolism (PubMed:9278457).	NA	Belongs to the MAPEG family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation;Aflatoxin activation and detoxification	PE1	1
+NX_O14893	Gem-associated protein 2	280	31585	5.43	0	Cytoplasm;Gem;Nucleolus;Nucleoplasm;Nucleus	NA	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.	NA	Belongs to the gemin-2 family.	RNA transport;snRNP Assembly	PE1	14
+NX_O14894	Transmembrane 4 L6 family member 5	197	20823	8.56	4	Nucleoplasm;Lysosome membrane;Cell junction;Cell membrane	NA	Acts as a lysosomal membrane arginine sensor (PubMed:30956113). Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations (PubMed:30956113). Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus (PubMed:20399237). CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression (PubMed:20399237).	NA	Belongs to the L6 tetraspanin family.	NA	PE1	17
+NX_O14896	Interferon regulatory factor 6	467	53130	5.18	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Popliteal pterygium syndrome;Van der Woude syndrome 1;Non-syndromic orofacial cleft 6	Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity).	Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.	Belongs to the IRF family.	Interferon gamma signaling;Interferon alpha/beta signaling	PE1	1
+NX_O14901	Krueppel-like factor 11	512	55139	8.45	0	Nucleoplasm;Cytosol;Focal adhesion;Nucleus	Maturity-onset diabetes of the young 7	Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	2
+NX_O14904	Protein Wnt-9a	365	40320	9.08	0	Extracellular matrix;Secreted	NA	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity.	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors);TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists	PE1	1
+NX_O14905	Protein Wnt-9b	357	39001	9.2	0	Extracellular matrix;Secreted	NA	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity).	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors)	PE1	17
+NX_O14907	Tax1-binding protein 3	124	13735	8.05	0	Cytoplasm;Cell membrane;Nucleolus;Cytoplasmic vesicle;Nucleus;Cytoskeleton	NA	May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.	NA	NA	RHO GTPases Activate Rhotekin and Rhophilins	PE1	17
+NX_O14908	PDZ domain-containing protein GIPC1	333	36049	5.9	0	Cytoplasm;Cell membrane;Cell junction;Membrane;Nucleoplasm	NA	May be involved in G protein-linked signaling.	NA	Belongs to the GIPC family.	NA	PE1	19
+NX_O14910	Protein lin-7 homolog A	233	25997	8.83	0	Cell membrane;Basolateral cell membrane;Cell junction;Tight junction;Postsynaptic density membrane	NA	Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.	NA	Belongs to the lin-7 family.	Dopamine Neurotransmitter Release Cycle;Neurexins and neuroligins;Assembly and cell surface presentation of NMDA receptors	PE1	12
+NX_O14917	Protocadherin-17	1159	126229	5.03	1	Cytoplasmic vesicle;Cytosol;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein.	NA	NA	NA	PE1	13
+NX_O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	756	86564	5.58	0	Cytoplasm;Cytosol;Membrane raft;Nucleus	Immunodeficiency 15A;Immunodeficiency 15B	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.	(Microbial infection) Monoubiquitination by TRIM21 is disrupted by Yersinia yopJ.;Hydroxylated by PHD1/EGLN2, loss of hydroxylation under hypoxic conditions results in activation of NF-kappa-B.;(Microbial infection) Acetylation of Thr-180 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B pathway.;Ubiquitinated. Monoubiquitination involves TRIM21 that leads to inhibition of Tax-induced NF-kappa-B signaling. According to PubMed:19675099, 'Ser-163' does not serve as a monoubiquitination site. According to PubMed:16267042, ubiquitination on 'Ser-163' modulates phosphorylation on C-terminal serine residues.;Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-181 by MEKK1 and/or MAP3K14/NIK as well as TBK1 and PRKCZ; which enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which decreases activity and prevents prolonged activation of the inflammatory response. Phosphorylated by the IKK-related kinases TBK1 and IKBKE, which is associated with reduced CHUK/IKKA and IKBKB activity and NF-kappa-B-dependent gene transcription. Dephosphorylated at Ser-177 and Ser-181 by PPM1A and PPM1B.;IKBKB is phosphorylated by MAP3K1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);IKBKB is phosphorylated by PRKCI	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	MAPK signaling pathway;Chemokine signaling pathway;Apoptosis;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Neurotrophin signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Type II diabetes mellitus;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Hepatitis C;Influenza A;HTLV-I infection;Pathways in cancer;Pancreatic cancer;Prostate cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Activation of NF-kappaB in B cells;ER-Phagosome pathway;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Downstream TCR signaling;NOD1/2 Signaling Pathway;RIP-mediated NFkB activation via ZBP1;p75NTR recruits signalling complexes;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;IKK complex recruitment mediated by RIP1;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;NF-kB is activated and signals survival;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;TICAM1, RIP1-mediated IKK complex recruitment;Interleukin-1 signaling	PE1	8
+NX_O14921	Regulator of G-protein signaling 13	159	19135	9.07	0	NA	NA	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).	NA	NA	G alpha (i) signalling events;G alpha (q) signalling events	PE2	1
+NX_O14924	Regulator of G-protein signaling 12	1447	156357	7.2	0	Cytoplasm;Nucleus matrix;Nucleolus;Nucleoplasm;Synapse;Cytosol;Dendrite;Nucleus	NA	Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.;Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.	NA	NA	G alpha (i) signalling events	PE1	4
+NX_O14925	Mitochondrial import inner membrane translocase subunit Tim23	209	21943	8.81	3	Mitochondrion inner membrane;Mitochondrion	NA	Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	NA	Belongs to the Tim17/Tim22/Tim23 family.	Mitochondrial protein import	PE1	10
+NX_O14926	Fascin-2	492	55057	7.95	0	Stereocilium;Cytoskeleton	Retinitis pigmentosa 30	Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.	NA	Belongs to the fascin family.	NA	PE1	17
+NX_O14929	Histone acetyltransferase type B catalytic subunit	419	49513	5.52	0	Nucleoplasm;Cytoplasm;Nucleus matrix;Nucleus	NA	Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.	NA	Belongs to the HAT1 family.	HATs acetylate histones	PE1	2
+NX_O14931	Natural cytotoxicity triggering receptor 3	201	21593	9.17	1	Cell membrane	NA	Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.	NA	Belongs to the natural cytotoxicity receptor (NCR) family.	Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	6
+NX_O14933	Ubiquitin/ISG15-conjugating enzyme E2 L6	153	17769	7.72	0	Cytosol	NA	Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.	ISGylated.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Parkinson's disease;Antigen processing: Ubiquitination & Proteasome degradation;ISG15 antiviral mechanism;Amyloid fiber formation;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;Termination of translesion DNA synthesis	PE1	11
+NX_O14936	Peripheral plasma membrane protein CASK	926	105123	5.99	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	FG syndrome 4;Mental retardation and microcephaly with pontine and cerebellar hypoplasia	Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.	Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.;Belongs to the MAGUK family.	Tight junction;Syndecan interactions;Nephrin family interactions;Dopamine Neurotransmitter Release Cycle;Neurexins and neuroligins;Assembly and cell surface presentation of NMDA receptors	PE1	X
+NX_O14939	Phospholipase D2	933	105987	7.41	0	Membrane	NA	May have a role in signal-induced cytoskeletal regulation and/or endocytosis.	Phosphorylated by FGR.;PLD2 is phosphorylated by FGR (Phosphotyrosine:PTM-0255)	Belongs to the phospholipase D family.	Glycerophospholipid metabolism;Ether lipid metabolism;Metabolic pathways;Endocytosis;Fc gamma R-mediated phagocytosis;Glutamatergic synapse;GnRH signaling pathway;Synthesis of PA;Role of phospholipids in phagocytosis;Synthesis of PG	PE1	17
+NX_O14944	Proepiregulin	169	19044	7.49	1	Cytoplasmic vesicle;Cell membrane;Extracellular space	NA	Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).	NA	NA	ErbB signaling pathway;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;EGFR downregulation;Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;PI3K events in ERBB4 signaling;SHC1 events in ERBB4 signaling;Nuclear signaling by ERBB4;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Signaling by EGFR;GAB1 signalosome;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;EGFR interacts with phospholipase C-gamma;Inhibition of Signaling by Overexpressed EGFR;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Extra-nuclear estrogen signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	4
+NX_O14948	Transcription factor EC	347	38788	5.3	0	Nucleoplasm;Nucleus	NA	Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.	NA	Belongs to the MiT/TFE family.	NA	PE1	7
+NX_O14949	Cytochrome b-c1 complex subunit 8	82	9906	10.07	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex III deficiency, nuclear 4	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone.	NA	Belongs to the UQCRQ/QCR8 family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport	PE1	5
+NX_O14950	Myosin regulatory light chain 12B	172	19779	4.71	0	Cytoplasm	NA	Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.	Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment.;MYL12B is phosphorylated by DAPK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Focal adhesion;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;EPHA-mediated growth cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate CIT;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs	PE1	18
+NX_O14957	Cytochrome b-c1 complex subunit 10	56	6570	9.87	1	Mitochondrion inner membrane	NA	This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.;This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.	NA	Belongs to the UQCR11/QCR10 family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport	PE1	19
+NX_O14958	Calsequestrin-2	399	46436	4.22	0	Sarcoplasmic reticulum lumen	Ventricular tachycardia, catecholaminergic polymorphic, 2	Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.	N-glycosylated.;Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity.	Belongs to the calsequestrin family.	Stimuli-sensing channels;Ion homeostasis	PE1	1
+NX_O14960	Leukocyte cell-derived chemotaxin-2	151	16390	9.49	0	Cytoplasm;Secreted	NA	Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).	NA	Belongs to the LECT2/MIM-1 family.	NA	PE1	5
+NX_O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	777	86192	5.84	0	Cytoplasm;Endosome;Lysosome;Early endosome membrane;Cytosol;Multivesicular body membrane	NA	Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.	Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.;Ubiquitinated (PubMed:25588945). Ubiquitinated by ITCH (PubMed:14602072, PubMed:24790097).	NA	Endosomal Sorting Complex Required For Transport (ESCRT);EGFR downregulation;Lysosome Vesicle Biogenesis;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Negative regulation of MET activity;InlB-mediated entry of Listeria monocytogenes into host cell	PE1	17
+NX_O14965	Aurora kinase A	403	45809	9.45	0	Centriole;Cilium basal body;Nucleoplasm;Spindle pole;Centrosome;Cytosol;Neuron projection	NA	Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.	Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome (By similarity). Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome (PubMed:10851084, PubMed:11039908). Ubiquitinated by the CUL3-KLHL18 ligase leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). Ubiquitination mediated by CUL3-KLHL18 ligase does not lead to its degradation by the proteasome (PubMed:23213400).;Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis. Phosphorylation at Ser-342 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);AURKA is phosphorylated by LIMK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);AURKA is phosphorylated by SRC (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.	Oocyte meiosis;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Regulation of PLK1 Activity at G2/M Transition;SUMOylation of DNA replication proteins;AURKA Activation by TPX2;Regulation of TP53 Activity through Phosphorylation;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Interaction between PHLDA1 and AURKA;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	PE1	20
+NX_O14966	Ras-related protein Rab-7L1	203	23155	6.73	0	trans-Golgi network;Golgi apparatus;Cytoplasm;Vacuole;Cell membrane;Perinuclear region;Cytoskeleton	NA	The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection (PubMed:22042847).	In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells (PubMed:22042847).	Belongs to the small GTPase superfamily. Rab family.	RAB geranylgeranylation	PE1	1
+NX_O14967	Calmegin	610	70039	4.58	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).	NA	Belongs to the calreticulin family.	NA	PE1	4
+NX_O14972	Vacuolar protein sorting-associated protein 26C	297	33010	7.6	0	Endosome;Mitochondrion	NA	Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079).;(Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface.	NA	Belongs to the VPS26 family.	NA	PE1	21
+NX_O14974	Protein phosphatase 1 regulatory subunit 12A	1030	115281	5.31	0	Cytoplasm;Stress fiber;Cytosol;Cytoskeleton	NA	Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.	Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR. In vitro, phosphorylation of Ser-695 by PKA and PKG appears to prevent phosphorylation of the inhibitory site Thr-696, probably mediated by PRKG1. Phosphorylation at Ser-445, Ser-472 and Ser-910 by NUAK1 promotes interaction with 14-3-3, leading to inhibit interaction with myosin light chain MLC2, preventing dephosphorylation of MLC2. May be phosphorylated at Thr-696 by DMPK; may inhibit the myosin phosphatase activity. Phosphorylated at Ser-473 by CDK1 during mitosis, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates PPP1R12A.;PPP1R12A is phosphorylated by ROCK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PPP1R12A is phosphorylated by DAPK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PPP1R12A is phosphorylated by NUAK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PPP1R12A is phosphorylated by CDC42BPA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Vascular smooth muscle contraction;Focal adhesion;Long-term potentiation;Regulation of actin cytoskeleton;Regulation of PLK1 Activity at G2/M Transition;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs	PE1	12
+NX_O14975	Very long-chain acyl-CoA synthetase	620	70312	8.75	3	Peroxisome membrane;Endoplasmic reticulum membrane;Microsome;Cell membrane	NA	Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.;Acyl CoA synthetase that activates long-chain and very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed:10198260, PubMed:10749848, PubMed:11980911). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake (PubMed:20530735).;Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids (PubMed:21768100). Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol (PubMed:21768100).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	PPAR signaling pathway;Peroxisome;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Alpha-oxidation of phytanate;Neutrophil degranulation;Peroxisomal protein import	PE1	15
+NX_O14976	Cyclin-G-associated kinase	1311	143191	5.49	0	trans-Golgi network;Golgi apparatus;Focal adhesion;Cytoplasmic vesicle;Perinuclear region	NA	Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis	PE1	4
+NX_O14977	Antizyme inhibitor 1	448	49535	4.66	0	Cytoplasmic vesicle;Nucleus	NA	Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240).	Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.	Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.	Regulation of ornithine decarboxylase (ODC)	PE1	8
+NX_O14978	Zinc finger protein 263	683	77299	6.54	0	Nucleoplasm;Cytosol;Spindle;Nucleus	NA	Might play an important role in basic cellular processes as a transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_O14979	Heterogeneous nuclear ribonucleoprotein D-like	420	46438	9.59	0	Cytoplasm;Nucleoplasm;Nucleus	Muscular dystrophy, limb-girdle, autosomal dominant 3	Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.	Dimethylation of Arg-408 is probably of the asymmetric type.	NA	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	4
+NX_O14980	Exportin-1	1071	123386	5.71	0	Cajal body;Cytoplasm;Nucleus membrane;Nucleolus;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.;(Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.	NA	Belongs to the exportin family.	Ribosome biogenesis in eukaryotes;RNA transport;Influenza A;HTLV-I infection;Separation of Sister Chromatids;MAPK6/MAPK4 signaling;Rev-mediated nuclear export of HIV RNA;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Cyclin A/B1/B2 associated events during G2/M transition;Downregulation of TGF-beta receptor signaling;Deactivation of the beta-catenin transactivating complex;HuR (ELAVL1) binds and stabilizes mRNA;NEP/NS2 Interacts with the Cellular Export Machinery;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	2
+NX_O14981	TATA-binding protein-associated factor 172	1849	206887	6.08	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.	NA	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	10
+NX_O14983	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	1001	110252	5.07	10	Endoplasmic reticulum;Endoplasmic reticulum membrane;Sarcoplasmic reticulum membrane	Brody myopathy	Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677).	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.	Calcium signaling pathway;Pancreatic secretion;Alzheimer's disease;Ion transport by P-type ATPases;Pre-NOTCH Processing in Golgi;Reduction of cytosolic Ca++ levels;Ion homeostasis	PE1	16
+NX_O14986	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	540	61036	6.39	0	Nucleoplasm;Endomembrane system;Cytoplasmic vesicle	NA	Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Endocytosis;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Synthesis of PIPs at the plasma membrane;WNT mediated activation of DVL;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	9
+NX_O14990	Protein phosphatase inhibitor 2 family member C	202	22660	5.04	0	NA	NA	Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates.	NA	Belongs to the protein phosphatase inhibitor 2 family.	NA	PE1	X
+NX_O14994	Synapsin-3	580	63303	9.42	0	Synaptic vesicle membrane	NA	May be involved in the regulation of neurotransmitter release and synaptogenesis.	Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.	Belongs to the synapsin family.	Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle	PE1	22
+NX_O15013	Rho guanine nucleotide exchange factor 10	1369	151612	5.46	0	Nucleoplasm	Slowed nerve conduction velocity	May play a role in developmental myelination of peripheral nerves.	Methylated at Gln-1338 by N6AMT1.	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	8
+NX_O15014	Zinc finger protein 609	1411	151191	8.24	0	Nucleoplasm;Cytosol;Nucleus	NA	Involved in the regulation of myoblast proliferation during myogenesis.;Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.	NA	NA	NA	PE1	15
+NX_O15015	Zinc finger protein 646	1832	200825	6.8	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	16
+NX_O15016	Tripartite motif-containing protein 66	1216	134663	6.53	0	Nucleoplasm;Nucleus	NA	May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).	NA	NA	NA	PE1	11
+NX_O15018	PDZ domain-containing protein 2	2839	301641	7.14	0	Cytoplasm;Cell membrane;Secreted;Endoplasmic reticulum;Cytosol;Nucleus	NA	NA	A secreted form is produced by caspase-mediated proteolytic cleavage.	NA	NA	PE1	5
+NX_O15020	Spectrin beta chain, non-erythrocytic 2	2390	271325	5.79	0	Cytosol;Cell junction;Cytoskeleton;Cell cortex	Spinocerebellar ataxia, autosomal recessive, 14;Spinocerebellar ataxia 5	Probably plays an important role in neuronal membrane skeleton.	NA	Belongs to the spectrin family.	RAF/MAP kinase cascade;MHC class II antigen presentation;Interaction between L1 and Ankyrins;NCAM signaling for neurite out-growth;COPI-mediated anterograde transport	PE1	11
+NX_O15021	Microtubule-associated serine/threonine-protein kinase 4	2623	284097	8.85	0	Nucleoplasm;Cytoplasm;Cytosol	NA	NA	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	NA	PE1	5
+NX_O15027	Protein transport protein Sec16A	2357	251894	5.51	0	Microsome membrane;Golgi apparatus;Endoplasmic reticulum membrane;Endoplasmic reticulum;Golgi apparatus membrane;Cytosol;Perinuclear region	NA	Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:17005010, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity).	NA	Belongs to the SEC16 family.	COPII-mediated vesicle transport	PE1	9
+NX_O15031	Plexin-B2	1838	205127	5.85	1	Cell membrane	NA	Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458). Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888). May modulate the activity of RAC1 and CDC42 (By similarity).	NA	Belongs to the plexin family.	Axon guidance	PE1	22
+NX_O15033	Apoptosis-resistant E3 ubiquitin protein ligase 1	823	94223	6.85	0	Cytosol	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.	Autoubiquitinated in vitro in the presence of E2 enzyme UBE2D1/UBCH5A.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination & Proteasome degradation	PE1	14
+NX_O15034	RIMS-binding protein 2	1052	116026	5.16	0	Golgi apparatus;Cell membrane;Nucleoplasm;Synapse;Cytosol	NA	Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.	NA	Belongs to the RIMBP family.	NA	PE1	12
+NX_O15037	Protein KHNYN	678	74534	6.57	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the N4BP1 family.	NA	PE1	14
+NX_O15040	Tectonin beta-propeller repeat-containing protein 2	1411	153848	5.34	0	Nucleoplasm	Spastic paraplegia 49, autosomal recessive	Probably plays a role as positive regulator of autophagy.	NA	Belongs to the WD repeat KIAA0329 family.	NA	PE1	14
+NX_O15041	Semaphorin-3E	775	89228	7.2	0	Cytoplasmic vesicle;Nucleoplasm;Secreted	NA	Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).	NA	Belongs to the semaphorin family.	Axon guidance;Other semaphorin interactions	PE1	7
+NX_O15042	U2 snRNP-associated SURP motif-containing protein	1029	118292	8.59	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the splicing factor SR family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	3
+NX_O15047	Histone-lysine N-methyltransferase SETD1A	1707	186034	5.07	0	Nucleus speckle;Chromosome	NA	Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	Lysine degradation;PKMTs methylate histone lysines;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	16
+NX_O15049	NEDD4-binding protein 3	544	60470	8.33	0	Nucleoplasm;Centrosome;Cytoplasmic vesicle;Axon;Dendrite	NA	Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage.	NA	Belongs to the N4BP3 family.	NA	PE1	5
+NX_O15050	TPR and ankyrin repeat-containing protein 1	2925	336221	6.34	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	3
+NX_O15054	Lysine-specific demethylase 6B	1643	176632	8.83	0	Nucleus speckle;Nucleus	NA	Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).	NA	Belongs to the UTX family.	Oxidative Stress Induced Senescence;HDMs demethylate histones	PE1	17
+NX_O15055	Period circadian protein homolog 2	1255	136579	6.04	0	Cytoplasm;Nucleus;Perinuclear region;Nucleolus	Advanced sleep phase syndrome, familial, 1	Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-ARTNL/BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-ARTNL/BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like ARNTL or G6PC. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1.	Acetylated. Deacetylated by SIRT1, resulting in decreased protein stability.;Phosphorylated by CSNK1E and CSNK1D. Phosphorylation results in PER2 protein degradation. May be dephosphorylated by PP1.;Ubiquitinated, leading to its proteasomal degradation. Ubiquitination may be inhibited by CRY1.	NA	Circadian rhythm - mammal;Herpes simplex infection;Circadian Clock	PE1	2
+NX_O15056	Synaptojanin-2	1496	165538	6.96	0	Cytoplasm;Cell membrane;Presynapse;Cytosol;Membrane raft;Cytoskeleton	NA	Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.	NA	In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.;Belongs to the synaptojanin family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the plasma membrane;Clathrin-mediated endocytosis	PE1	6
+NX_O15060	Zinc finger and BTB domain-containing protein 39	712	79001	6.06	0	Cytoplasmic vesicle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	12
+NX_O15061	Synemin	1565	172768	5.09	0	Adherens junction;Cytoskeleton	NA	Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.	NA	Belongs to the intermediate filament family.	NA	PE1	15
+NX_O15062	Zinc finger and BTB domain-containing protein 5	677	74278	5.79	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	9
+NX_O15063	Uncharacterized protein KIAA0355	1070	116020	6.72	0	Cytoplasm;Nucleoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_O15066	Kinesin-like protein KIF3B	747	85125	7.3	0	Golgi apparatus;Cilium;Nucleolus;Nucleoplasm;Cytoskeleton	NA	Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.	MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	20
+NX_O15067	Phosphoribosylformylglycinamidine synthase	1338	144734	5.5	0	Cytoplasmic vesicle;Cytoplasm	NA	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity).	NA	In the N-terminal section; belongs to the FGAMS family.	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.;Purine metabolism;Metabolic pathways;Purine ribonucleoside monophosphate biosynthesis	PE1	17
+NX_O15068	Guanine nucleotide exchange factor DBS	1137	128109	6.02	0	Cytoplasm;Endomembrane system;Cell membrane	NA	Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity).;Activates CDC42 (PubMed:15157669).;Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669).	NA	Belongs to the MCF2 family.	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	13
+NX_O15069	NAC-alpha domain-containing protein 1	1562	161101	4.12	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).	NA	Belongs to the NAC-alpha family.	NA	PE1	7
+NX_O15072	A disintegrin and metalloproteinase with thrombospondin motifs 3	1205	135603	6.76	0	Extracellular matrix;Secreted;Cytoskeleton	Hennekam lymphangiectasia-lymphedema syndrome 3	Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.	The precursor is cleaved by a furin endopeptidase.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	O-glycosylation of TSR domain-containing proteins;Collagen biosynthesis and modifying enzymes;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	4
+NX_O15075	Serine/threonine-protein kinase DCLK1	740	82224	8.84	0	Nucleoplasm;Cytosol	NA	Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.	Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	NA	PE1	13
+NX_O15078	Centrosomal protein of 290 kDa	2479	290386	5.75	0	Centriole;Centriolar satellite;Cilium;Cilium basal body;Centrosome;Cytoplasmic vesicle;Nucleus	Senior-Loken syndrome 6;Leber congenital amaurosis 10;Meckel syndrome 4;Bardet-Biedl syndrome 14;Joubert syndrome 5	Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973).	Ubiquitinated. May undergo monoubiquitination; monoubiquitination is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, but does not cause it displacement from centriolar satellites.	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2;Neutrophil degranulation	PE1	12
+NX_O15079	Syntaphilin	494	53537	5.41	1	Membrane;Mitochondrion;Cytoskeleton;Synaptosome	NA	Inhibits SNARE complex formation by absorbing free syntaxin-1.	NA	NA	NA	PE1	20
+NX_O15083	ERC protein 2	957	110558	6.51	0	Cytoplasm;Cytoskeleton;Synapse;Synaptosome	NA	Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.	NA	NA	NA	PE1	3
+NX_O15084	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A	1053	112966	5.8	0	Nucleoplasm	NA	Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.	NA	NA	COPII-mediated vesicle transport	PE1	3
+NX_O15085	Rho guanine nucleotide exchange factor 11	1522	167704	5.33	0	Membrane;Nucleoplasm;Cytoplasm;Cell membrane	NA	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.	Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex when previously phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14), leading to its degradation, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth.;Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14).	NA	Vascular smooth muscle contraction;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;Sema4D induced cell migration and growth-cone collapse	PE1	1
+NX_O15090	Zinc finger protein 536	1300	141417	6.86	0	Nucleoplasm;Cell junction;Nucleus	NA	May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_O15091	Mitochondrial ribonuclease P catalytic subunit	583	67315	8.97	0	Nucleoplasm;Mitochondrion	NA	Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853).	Degraded by LONP1 following mitochondrial unfolded protein response, probably leading to inhibit translation in mitochondrion.	Belongs to the PPR family. P subfamily.	tRNA processing in the mitochondrion;tRNA modification in the mitochondrion;rRNA processing in the mitochondrion	PE1	14
+NX_O15105	Mothers against decapentaplegic homolog 7	426	46426	8.63	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Colorectal cancer 3	Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.	Ubiquitinated by WWP1 (By similarity). Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation (PubMed:14657019, PubMed:16601693). In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation (PubMed:11278251).;Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (By similarity). Phosphorylated by PDPK1.;Acetylation prevents ubiquitination and degradation mediated by SMURF1.	Belongs to the dwarfin/SMAD family.	Endocytosis;TGF-beta signaling pathway;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Signaling by BMP;Downregulation of TGF-beta receptor signaling;UCH proteinases;Ub-specific processing proteases	PE1	18
+NX_O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	745	84640	6.27	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	Cocoon syndrome	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260).	(Microbial infection) Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.;Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.;CHUK is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);CHUK is phosphorylated by MAP3K1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	MAPK signaling pathway;Chemokine signaling pathway;Apoptosis;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Adipocytokine signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Hepatitis C;Measles;HTLV-I infection;Pathways in cancer;Pancreatic cancer;Prostate cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Activation of NF-kappaB in B cells;ER-Phagosome pathway;FCERI mediated NF-kB activation;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;NIK-->noncanonical NF-kB signaling;Downstream TCR signaling;NOD1/2 Signaling Pathway;RIP-mediated NFkB activation via ZBP1;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;Constitutive Signaling by AKT1 E17K in Cancer;IKK complex recruitment mediated by RIP1;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;AKT phosphorylates targets in the cytosol;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;TICAM1, RIP1-mediated IKK complex recruitment;Interleukin-1 signaling	PE1	10
+NX_O15116	U6 snRNA-associated Sm-like protein LSm1	133	15179	5.11	0	Cytoplasm;Cytosol;P-body;Cytoplasmic vesicle	NA	Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity).	NA	Belongs to the snRNP Sm proteins family.	RNA degradation;mRNA decay by 5' to 3' exoribonuclease	PE1	8
+NX_O15117	FYN-binding protein 1	783	85387	6.11	0	Cytoplasm;Cell membrane;Cell junction;Nucleoplasm;Nucleus	Thrombocytopenia 3	Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.	T-cell receptor ligation leads to increased tyrosine phosphorylation.	NA	Generation of second messenger molecules;Signal regulatory protein family interactions	PE1	5
+NX_O15118	NPC intracellular cholesterol transporter 1	1278	142167	5.17	13	Nucleoplasm;Lysosome membrane;Late endosome membrane;Cytoplasmic vesicle	Niemann-Pick disease C1	(Microbial infection) Acts as an endosomal entry receptor for ebolavirus.;Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:9211849, PubMed:9927649, PubMed:10821832, PubMed:18772377, PubMed:27238017, PubMed:12554680). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:9211849, PubMed:9927649, PubMed:18772377, PubMed:19563754, PubMed:27238017, PubMed:28784760). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed:19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).	N-glycosylated.	Belongs to the patched family.	Lysosome;LDL clearance	PE1	18
+NX_O15119	T-box transcription factor TBX3	743	79389	8.3	0	Nucleoplasm;Cytosol;Nucleus	Ulnar-mammary syndrome	Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.	NA	NA	NA	PE1	12
+NX_O15120	1-acyl-sn-glycerol-3-phosphate acyltransferase beta	278	30914	9.21	2	Endoplasmic reticulum membrane;Centrosome	Congenital generalized lipodystrophy 1	Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.;Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Fat digestion and absorption;Synthesis of PA;Neutrophil degranulation	PE1	9
+NX_O15121	Sphingolipid delta(4)-desaturase DES1	323	37866	6.97	6	Membrane;Endoplasmic reticulum membrane;Mitochondrion	NA	Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).	Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels.	Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.	Sphingolipid metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis;Neutrophil degranulation	PE1	1
+NX_O15123	Angiopoietin-2	496	56919	5.41	0	Secreted	NA	Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.	NA	NA	Tie2 Signaling	PE1	8
+NX_O15126	Secretory carrier-associated membrane protein 1	338	37920	7.03	4	trans-Golgi network membrane;Cell junction;Nucleoplasm;Recycling endosome membrane;Cytoplasmic vesicle	NA	Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.	NA	Belongs to the SCAMP family.	Neutrophil degranulation	PE1	5
+NX_O15127	Secretory carrier-associated membrane protein 2	329	36649	5.72	4	Golgi apparatus;Cell membrane;trans-Golgi network membrane;Recycling endosome membrane;Cytoplasmic vesicle	NA	Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.	NA	Belongs to the SCAMP family.	NA	PE1	15
+NX_O15130	Pro-FMRFamide-related neuropeptide FF	113	12440	5.04	0	Secreted	NA	Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.	NA	Belongs to the FARP (FMRFamide related peptide) family.	G alpha (q) signalling events;Orexin and neuropeptides FF and QRFP bind to their respective receptors	PE2	12
+NX_O15131	Importin subunit alpha-6	536	60349	5.07	0	Cytoplasm;Cytosol	NA	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.	NA	Belongs to the importin alpha family.	ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways	PE1	6
+NX_O15143	Actin-related protein 2/3 complex subunit 1B	372	40950	8.68	0	Cytoplasmic vesicle;Cytosol;Nucleus;Cytoskeleton	Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease	Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).	NA	Belongs to the WD repeat ARPC1 family.	Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;EPHB-mediated forward signaling	PE1	7
+NX_O15144	Actin-related protein 2/3 complex subunit 2	300	34333	6.84	0	Cytoplasm;Golgi apparatus;Synaptosome;Cell projection;Cytosol;Nucleus;Cytoskeleton	NA	Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).	NA	Belongs to the ARPC2 family.	Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;EPHB-mediated forward signaling;Clathrin-mediated endocytosis	PE1	2
+NX_O15145	Actin-related protein 2/3 complex subunit 3	178	20547	8.78	0	Cytoplasm;Cell projection;Nucleoplasm;Nucleus;Cytoskeleton	NA	Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).	NA	Belongs to the ARPC3 family.	Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;EPHB-mediated forward signaling;Clathrin-mediated endocytosis	PE1	12
+NX_O15146	Muscle, skeletal receptor tyrosine-protein kinase	869	97056	6.96	1	Postsynaptic cell membrane	Fetal akinesia deformation sequence 1;Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency	Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).	Phosphorylated (By similarity). Phosphorylation is induced by AGRIN in a LRP4-dependent manner (By similarity). Autophosphorylated (PubMed:25029443). Autophosphorylation at Tyr-554 is required for interaction with DOK7 which in turn stimulates the phosphorylation and the activation of MUSK (By similarity).;Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation (By similarity).;Neddylated.	Belongs to the protein kinase superfamily. Tyr protein kinase family.	ECM proteoglycans	PE1	9
+NX_O15151	Protein Mdm4	490	54864	4.85	0	Nucleoplasm;Nucleus	NA	Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.	Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein.;Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent.;MDM4 is phosphorylated by CHEK2	Belongs to the MDM2/MDM4 family.	p53 signaling pathway;Oxidative Stress Induced Senescence;Oncogene Induced Senescence;Stabilization of p53;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Ub-specific processing proteases	PE1	1
+NX_O15155	BET1 homolog	118	13289	9.14	1	cis-Golgi network membrane;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity).	NA	Belongs to the BET1 family.	SNARE interactions in vesicular transport;COPII-mediated vesicle transport;COPI-mediated anterograde transport	PE1	7
+NX_O15156	Zinc finger and BTB domain-containing protein 7B	539	58027	5.53	0	Nucleoplasm;Nucleus	NA	Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. Induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity).	Acetylated directly and specifically by EP300 (PubMed:20810990). EP300-mediated acetylation of Lys-206, Lys-212 and Lys-335 stabilizes the protein by antagonizing ubiquitin conjugation (By similarity).;Ubiquitinated, leading to proteasomal degradation (PubMed:20810990). Competes with acetylation on Lys-206, Lys-212 and Lys-335 (By similarity).	NA	NA	PE1	1
+NX_O15160	DNA-directed RNA polymerases I and III subunit RPAC1	346	39250	5.31	0	Nucleoplasm;Nucleus	Leukodystrophy, hypomyelinating, 11;Treacher Collins syndrome 3	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).	NA	Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;B-WICH complex positively regulates rRNA expression	PE1	6
+NX_O15162	Phospholipid scramblase 1	318	35049	4.83	1	Golgi apparatus;Cytoplasm;Cell membrane;Membrane;Nucleoplasm;Perinuclear region;Nucleus	NA	May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.;May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.	Phosphorylated by OXSR1 in the presence of RELT.	Belongs to the phospholipid scramblase family.	NA	PE1	3
+NX_O15164	Transcription intermediary factor 1-alpha	1050	116831	6.73	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).	Sumoylated.	NA	Protein modification; protein ubiquitination.;Signaling by FGFR1 in disease;Signaling by cytosolic FGFR1 fusion mutants;Signaling by BRAF and RAF fusions	PE1	7
+NX_O15165	Low-density lipoprotein receptor class A domain-containing protein 4	306	33900	5.86	1	Early endosome membrane;Cytoplasmic vesicle	NA	Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.	NA	Belongs to the PMEPA1 family.	NA	PE1	18
+NX_O15169	Axin-1	862	95635	6.5	0	Cytoplasm;Cell membrane;Nucleolus;Membrane;Cytoplasmic vesicle;Nucleus	Hepatocellular carcinoma;Caudal duplication anomaly	Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684).	Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Sumoylation at Lys-857 and Lys-860 prevents ubiquitination and degradation. Sumoylation is required for AXIN1-mediated JNK activation. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important for nuclear accumulation during Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.;Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1.;ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination at 'Lys-48' and subsequent activation of the Wnt signaling pathway.	NA	Wnt signaling pathway;Pathways in cancer;Colorectal cancer;Endometrial cancer;Basal cell carcinoma;Degradation of beta-catenin by the destruction complex;Degradation of AXIN;TCF dependent signaling in response to WNT;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Ub-specific processing proteases;RUNX1 regulates estrogen receptor mediated transcription;RUNX1 regulates transcription of genes involved in WNT signaling;Estrogen-dependent gene expression	PE1	16
+NX_O15172	Putative phosphoserine phosphatase-like protein	72	7804	6.02	0	NA	NA	NA	NA	Belongs to the HAD-like hydrolase superfamily. SerB family.	NA	PE5	7
+NX_O15173	Membrane-associated progesterone receptor component 2	223	23818	4.76	1	Membrane;Cytosol;Nucleus;Cell membrane	NA	Receptor for steroids.	NA	Belongs to the cytochrome b5 family. MAPR subfamily.	NA	PE1	4
+NX_O15178	T-box transcription factor T	435	47443	6.62	0	Nucleoplasm;Nucleus	Neural tube defects;Chordoma;Sacral agenesis with vertebral anomalies	Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.	NA	NA	NA	PE1	6
+NX_O15182	Centrin-3	167	19550	4.62	0	Centriole;Nuclear pore complex;Nucleolus;Centrosome;Nucleus envelope	NA	Plays a fundamental role in microtubule-organizing center structure and function.;As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.	NA	Belongs to the centrin family.	NA	PE1	5
+NX_O15194	CTD small phosphatase-like protein	276	31129	5.32	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.	NA	NA	NA	PE1	3
+NX_O15195	Villin-like protein	856	95907	6.55	0	NA	NA	Possible tumor suppressor.	NA	Belongs to the villin/gelsolin family.	NA	PE1	3
+NX_O15197	Ephrin type-B receptor 6	1021	110700	6.19	1	Membrane;Nucleus speckle;Secreted	NA	Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.	Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells	PE1	7
+NX_O15198	Mothers against decapentaplegic homolog 9	467	52493	7.87	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Pulmonary hypertension, primary, 2	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).	Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.	Belongs to the dwarfin/SMAD family.	TGF-beta signaling pathway;Signaling by BMP	PE1	13
+NX_O15204	ADAM DEC1	470	52775	7.01	0	Secreted	NA	May play an important role in the control of the immune response and during pregnancy.	NA	NA	NA	PE1	8
+NX_O15205	Ubiquitin D	165	18473	9.08	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	NA	Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).	Can be acetylated.	NA	Neddylation	PE1	6
+NX_O15209	Zinc finger and BTB domain-containing protein 22	634	65602	5.93	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_O15211	Ral guanine nucleotide dissociation stimulator-like 2	777	83549	5.82	0	Nucleoplasm	NA	Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).	NA	NA	NA	PE1	6
+NX_O15212	Prefoldin subunit 6	129	14583	8.83	0	Golgi apparatus;Nucleoplasm	NA	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.	NA	Belongs to the prefoldin subunit beta family.	Prefoldin mediated transfer of substrate to CCT/TriC	PE1	6
+NX_O15213	WD repeat-containing protein 46	610	68071	9.69	0	Nucleolus	NA	Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.	NA	NA	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	6
+NX_O15217	Glutathione S-transferase A4	222	25704	7.89	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).	NA	Belongs to the GST superfamily. Alpha family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation	PE1	6
+NX_O15218	G-protein coupled receptor 182	404	45323	7.28	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	12
+NX_O15225	Putative inactivation escape 1 protein	51	5365	7	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_O15226	NF-kappa-B-repressing factor	690	77673	8.94	0	Nucleoplasm;Nucleolus	NA	Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.	NA	NA	NA	PE1	X
+NX_O15228	Dihydroxyacetone phosphate acyltransferase	680	77188	6.16	0	Peroxisome membrane	Rhizomelic chondrodysplasia punctata 2	NA	NA	Belongs to the GPAT/DAPAT family.	Membrane lipid metabolism; glycerophospholipid metabolism.;Glycerophospholipid metabolism;Peroxisome;Synthesis of PA;Plasmalogen biosynthesis;Peroxisomal protein import	PE1	1
+NX_O15229	Kynurenine 3-monooxygenase	486	55810	9.18	2	Mitochondrion outer membrane	NA	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).	NA	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.;Tryptophan metabolism;Metabolic pathways;Tryptophan catabolism	PE1	1
+NX_O15230	Laminin subunit alpha-5	3695	399737	6.66	0	Nucleoplasm;Cytoplasmic vesicle;Basement membrane	NA	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	NA	NA	Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer;Degradation of the extracellular matrix;ECM proteoglycans;Non-integrin membrane-ECM interactions;Laminin interactions;MET activates PTK2 signaling;Interleukin-4 and Interleukin-13 signaling	PE1	20
+NX_O15231	Zinc finger protein 185	689	73525	6.68	0	Focal adhesion;Cytoskeleton	NA	May be involved in the regulation of cellular proliferation and/or differentiation.	NA	NA	NA	PE1	X
+NX_O15232	Matrilin-3	486	52817	6.25	0	Golgi apparatus;Endoplasmic reticulum;Secreted	Osteoarthritis 2;Multiple epiphyseal dysplasia 5;Spondyloepimetaphyseal dysplasia MATN3-related	Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.	NA	NA	ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	2
+NX_O15234	Protein CASC3	703	76278	6.05	0	Cytoplasm;Stress granule;Nucleus speckle;Perinuclear region;Nucleus membrane;Cytoplasmic ribonucleoprotein granule;Dendrite;Nucleus	NA	Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer.	Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation.;ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.	Belongs to the CASC3 family.	RNA transport;mRNA surveillance pathway;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Regulation of expression of SLITs and ROBOs;RNA Polymerase II Transcription Termination	PE1	17
+NX_O15235	28S ribosomal protein S12, mitochondrial	138	15173	10.31	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uS12 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	19
+NX_O15239	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	70	8072	8.93	1	Cytosol;Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 12	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFA1 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	X
+NX_O15240	Neurosecretory protein VGF	615	67258	4.76	0	Golgi apparatus;Cytoplasmic vesicle;Secreted;Secretory vesicle	NA	VGF-derived peptide TLQP-62: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity).;Neuroendocrine regulatory peptide-1: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons.;Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. Luteus, and antifungal activity against P. Pastoris.;Neurosecretory protein VGF: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity).;Neuroendocrine regulatory peptide-2: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity).;VGF-derived peptide TLQP-21: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity).	Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.	NA	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	7
+NX_O15243	Leptin receptor gene-related protein	131	14254	6.01	4	Golgi apparatus membrane;Centrosome;Endosome membrane	NA	Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.	NA	Belongs to the OB-RGRP/VPS55 family.	NA	PE1	1
+NX_O15244	Solute carrier family 22 member 2	555	62581	8.68	12	Membrane	NA	Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Na+/Cl- dependent neurotransmitter transporters;Abacavir transmembrane transport;Organic cation transport;Neurotransmitter clearance;Norepinephrine Neurotransmitter Release Cycle	PE1	6
+NX_O15245	Solute carrier family 22 member 1	554	61154	6.4	12	Basolateral cell membrane	NA	Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.	Phosphorylated.	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Bile secretion;Na+/Cl- dependent neurotransmitter transporters;Abacavir transmembrane transport;Organic cation transport;Neurotransmitter clearance;Norepinephrine Neurotransmitter Release Cycle	PE1	6
+NX_O15247	Chloride intracellular channel protein 2	247	28356	5.44	1	Cytoplasm;Cell membrane;Membrane;Nucleoplasm;Nucleus	Mental retardation, X-linked, syndromic, 32	Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.	NA	Belongs to the chloride channel CLIC family.	Stimuli-sensing channels;Ion homeostasis	PE1	X
+NX_O15254	Peroxisomal acyl-coenzyme A oxidase 3	700	77629	6.84	0	Peroxisome	NA	Oxidizes the CoA-esters of 2-methyl-branched fatty acids.	NA	Belongs to the acyl-CoA oxidase family.	Lipid metabolism; peroxisomal fatty acid beta-oxidation.;Fatty acid metabolism;alpha-Linolenic acid metabolism;Biosynthesis of unsaturated fatty acids;Metabolic pathways;PPAR signaling pathway;Peroxisome;Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import	PE1	4
+NX_O15255	CAAX box protein 1	209	22278	8.56	0	Cell membrane	NA	NA	NA	NA	NA	PE2	X
+NX_O15258	Protein RER1	196	22958	9.56	3	Golgi apparatus;Golgi apparatus membrane	NA	Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.	NA	Belongs to the RER1 family.	NA	PE1	1
+NX_O15259	Nephrocystin-1	732	83299	5.11	0	Adherens junction;Cell junction;Cilium;Tight junction;Cilium axoneme;Cytoplasmic vesicle	Nephronophthisis 1;Senior-Loken syndrome 1;Joubert syndrome 4	Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development (By similarity). In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity).	Phosphorylation by CK2 is required for the interaction with PACS1 and the targeting to the base region of cilia.	Belongs to the nephrocystin-1 family.	Anchoring of the basal body to the plasma membrane	PE1	2
+NX_O15260	Surfeit locus protein 4	269	30394	7.64	5	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.	NA	Belongs to the SURF4 family.	COPI-dependent Golgi-to-ER retrograde traffic;Neutrophil degranulation	PE1	9
+NX_O15263	Beta-defensin 4A	64	7038	9.46	0	Secreted	NA	Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).	NA	Belongs to the beta-defensin family. LAP/TAP subfamily.	Beta defensins;Defensins	PE1	8
+NX_O15264	Mitogen-activated protein kinase 13	365	42090	8.48	0	Nucleoplasm;Cytosol;Nucleolus	NA	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.	Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1.;MAPK13 is phosphorylated by MAP2K7	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK signaling pathway;VEGF signaling pathway;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Dopaminergic synapse;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Amyotrophic lateral sclerosis (ALS);Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Salmonella infection;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Hepatitis C;Influenza A;DSCAM interactions;NOD1/2 Signaling Pathway;VEGFA-VEGFR2 Pathway;p38MAPK events	PE1	6
+NX_O15265	Ataxin-7	892	95451	9.89	0	Cytoplasm;Nucleus matrix;Nucleolus;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Spinocerebellar ataxia 7	Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization.	Sumoylation decreases the aggregation propensity and cellular toxicity of forms with an expanded poly-Gln region but has no effect on subcellular location or interaction with components of the STAGA complex.;Proteolytically cleaved. The cleavage may be involved in SCA7 degeneration: the isoform fragments may exert distinct toxic influences that could contribute to selective neurodegeneration.	Belongs to the ataxin-7 family.	HATs acetylate histones;Ub-specific processing proteases	PE1	3
+NX_O15266	Short stature homeobox protein	292	32236	7.23	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	Langer mesomelic dysplasia;Short stature, idiopathic, X-linked;Leri-Weill dyschondrosteosis	Controls fundamental aspects of growth and development.	NA	Belongs to the paired homeobox family. Bicoid subfamily.	NA	PE1	X
+NX_O15269	Serine palmitoyltransferase 1	473	52744	5.72	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	Neuropathy, hereditary sensory and autonomic, 1A	Serine palmitoyltransferase (SPT) (PubMed:19416851). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core (PubMed:19416851). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851). Required for adipocyte cell viability and metabolic homeostasis (By similarity).	Phosphorylation at Tyr-164 inhibits activity and promotes cell survival.	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis	PE1	9
+NX_O15270	Serine palmitoyltransferase 2	562	62924	7.89	1	Endoplasmic reticulum membrane;Mitochondrion	Neuropathy, hereditary sensory and autonomic, 1C	Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity).	NA	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis	PE1	14
+NX_O15273	Telethonin	167	19052	5.2	0	Sarcomere	Muscular dystrophy, limb-girdle, autosomal recessive 7;Cardiomyopathy, familial hypertrophic 25	Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.	NA	NA	Striated Muscle Contraction	PE1	17
+NX_O15287	Fanconi anemia group G protein	622	68554	5.32	0	Cytoplasm;Cell membrane;Nucleolus;Cytosol;Nucleus	Fanconi anemia complementation group G	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.	NA	NA	Fanconi anemia pathway;Fanconi Anemia Pathway	PE1	9
+NX_O15294	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	1046	116925	6.22	0	Cytoplasm;Mitochondrion;Cell membrane;Cell projection;Membrane;Nucleoplasm;Mitochondrion membrane;Nucleus	Mental retardation, X-linked 106	The mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line.;Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539, PubMed:23103939, PubMed:21240259, PubMed:21285374, PubMed:15361863). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (PubMed:26678539). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins ARNTL/BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2 (PubMed:12150998, PubMed:19451179, PubMed:20018868, PubMed:20200153, PubMed:21285374, PubMed:15361863). O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (PubMed:21285374, PubMed:28584052, PubMed:28302723). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Glycosylates HOXA1 (By similarity).	Phosphorylation on Ser-3 or Ser-4 by GSK3-beta positively regulates its activity.;Ubiquitinated, leading to its proteasomal degradation.	Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;HATs acetylate histones;UCH proteinases	PE1	X
+NX_O15296	Arachidonate 15-lipoxygenase B	676	75857	5.73	0	Cell membrane;Membrane;Cytosol;Nucleus;Cytoskeleton	NA	Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.	NA	Belongs to the lipoxygenase family.	Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.;Arachidonic acid metabolism;Metabolic pathways;Synthesis of 15-eicosatetraenoic acid derivatives	PE1	17
+NX_O15297	Protein phosphatase 1D	605	66675	9.14	0	Endoplasmic reticulum;Cytosol;Nucleus	Breast cancer;Ovarian cancer;Intellectual developmental disorder with gastrointestinal difficulties and high pain threshold	Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).	NA	Belongs to the PP2C family.	p53 signaling pathway;Transcriptional regulation by RUNX2	PE1	17
+NX_O15303	Metabotropic glutamate receptor 6	877	95468	8.34	7	Endoplasmic reticulum membrane;Golgi apparatus membrane;Dendrite;Cell membrane	Night blindness, congenital stationary, 1B	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.	NA	Belongs to the G-protein coupled receptor 3 family.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	5
+NX_O15304	Apoptosis regulatory protein Siva	175	18695	7.86	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.	Phosphorylated by ABL2/ARG in response to oxidative stress.	NA	NA	PE1	14
+NX_O15305	Phosphomannomutase 2	246	28082	6.35	0	Nucleoplasm;Cytosol;Cytoplasm	Congenital disorder of glycosylation 1A	Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.	NA	Belongs to the eukaryotic PMM family.	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.;Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Synthesis of GDP-mannose;Defective PMM2 causes PMM2-CDG (CDG-1a)	PE1	16
+NX_O15315	DNA repair protein RAD51 homolog 2	384	42196	5.49	0	Nucleoplasm;Nucleus	NA	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.	Phosphorylated on tyrosine residues by BCR-ABL.	Belongs to the RecA family. RAD51 subfamily.	Homologous recombination;Factors involved in megakaryocyte development and platelet production;HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Presynaptic phase of homologous DNA pairing and strand exchange	PE1	14
+NX_O15318	DNA-directed RNA polymerase III subunit RPC7	223	25914	4.53	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:20154270). May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370).	NA	Belongs to the eukaryotic RPC7 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	5
+NX_O15321	Transmembrane 9 superfamily member 1	606	68861	6.7	9	Autophagosome membrane;Golgi apparatus;Lysosome membrane	NA	Plays an essential role in autophagy.	NA	Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	NA	PE1	14
+NX_O15327	Inositol polyphosphate 4-phosphatase type II	924	104738	5.87	0	Cytoplasm;Centrosome	NA	Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612).	NA	Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.	Signal transduction; phosphatidylinositol signaling pathway.;Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of IP2, IP, and Ins in the cytosol	PE1	4
+NX_O15335	Chondroadherin	359	40476	9.49	0	Extracellular matrix	NA	Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).	NA	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.	Focal adhesion;ECM-receptor interaction	PE1	17
+NX_O15342	V-type proton ATPase subunit e 1	81	9374	8.96	2	Membrane	NA	Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	NA	Belongs to the V-ATPase e1/e2 subunit family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE2	5
+NX_O15344	E3 ubiquitin-protein ligase Midline-1	667	75251	6.35	0	Cytoplasm;Spindle;Centriolar satellite;Cytoskeleton	Opitz GBBB syndrome 1	Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.	Phosphorylated on serine and threonine residues.	Belongs to the TRIM/RBCC family.	Ubiquitin mediated proteolysis;Interferon gamma signaling	PE1	X
+NX_O15347	High mobility group protein B3	200	22980	8.48	0	Cytoplasm;Nucleolus;Chromosome;Nucleoplasm;Nucleus	Microphthalmia, syndromic, 13	Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity).	Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-104 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB3 (HMGB3C23hC45hC104h), 2- disulfide HMGB3 (HMGB3C23-C45C104h) and 3- sulfonyl HMGB3 (HMGB3C23soC45soC104so).	Belongs to the HMGB family.	NA	PE1	X
+NX_O15350	Tumor protein p73	636	69623	6.47	0	Golgi apparatus;Nucleoplasm;Cytoplasm;Nucleus	NA	Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	(but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function.;Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome.;Higher levels of phosphorylation seen in the brain from patients with Huntington disease.;TP73 is phosphorylated by PLK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the p53 family.	p53 signaling pathway;Neurotrophin signaling pathway;Measles;Activation of PUMA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of Death Receptors and Ligands;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;TP53 Regulates Transcription of Caspase Activators and Caspases;Regulation of TP53 Activity through Association with Co-factors;RUNX1 regulates transcription of genes involved in differentiation of HSCs	PE1	1
+NX_O15353	Forkhead box protein N1	648	68925	5.93	0	Nucleus	T-cell immunodeficiency, congenital alopecia, and nail dystrophy	Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891).	NA	NA	NA	PE1	17
+NX_O15354	Prosaposin receptor GPR37	613	67114	8.68	7	Cytosol;Endoplasmic reticulum membrane;Nucleus membrane;Cell membrane	NA	Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.	Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.	Belongs to the G-protein coupled receptor 1 family.	Parkinson's disease;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	7
+NX_O15355	Protein phosphatase 1G	546	59272	4.28	0	Membrane;Nucleoplasm;Cytoplasm	NA	NA	NA	Belongs to the PP2C family.	NA	PE1	2
+NX_O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	1258	138599	6.1	0	Golgi apparatus;Nucleus speckle;Membrane;Lamellipodium;Filopodium;Cytosol;Nucleus;Cytoskeleton	Diabetes mellitus, non-insulin-dependent;Opsismodysplasia	Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification.	Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as insulin, growth factors such as EGF or PDGF, chemokines, integrin ligands and hypertonic and oxidative stress. May be phosphorylated upon IgG receptor FCGR2B-binding. Phosphorylated at Tyr-986 following cell attachment and spreading. Phosphorylated at Tyr-1162 following EGF signaling pathway stimulation. Phosphorylated at Thr-958 in response to PDGF.;INPPL1 is phosphorylated by SRC (Phosphotyrosine:PTM-0255)	Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the plasma membrane;Interleukin receptor SHC signaling;Synthesis of IP3 and IP4 in the cytosol	PE1	11
+NX_O15360	Fanconi anemia group A protein	1455	162775	6.13	0	Nucleoplasm;Cytoplasm;Nucleus	Fanconi anemia, complementation group A	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.	Phosphorylation is required for the formation of the nuclear complex. Not phosphorylated in cells derived from groups A, B, C, E, F, G, and H.	NA	Fanconi anemia pathway;Fanconi Anemia Pathway	PE1	16
+NX_O15370	Transcription factor SOX-12	315	34122	5.08	0	Nucleoplasm;Nucleus	NA	Binds to the sequence 5'-AACAAT-3'.	NA	NA	NA	PE1	20
+NX_O15371	Eukaryotic translation initiation factor 3 subunit D	548	63973	5.79	0	Cytoplasm;Cytosol	NA	(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).;MRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).	NA	Belongs to the eIF-3 subunit D family.	RNA transport;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	22
+NX_O15372	Eukaryotic translation initiation factor 3 subunit H	352	39930	6.09	0	Cytoplasm;Cytosol	NA	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).	NA	Belongs to the eIF-3 subunit H family.	RNA transport;Measles;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	8
+NX_O15374	Monocarboxylate transporter 5	487	54022	8.25	12	Cytosol;Cell membrane;Cytoskeleton	NA	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	NA	PE1	1
+NX_O15375	Monocarboxylate transporter 6	505	54994	8.59	12	Cell membrane	NA	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	NA	PE1	17
+NX_O15379	Histone deacetylase 3	428	48848	4.98	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol;Nucleus	NA	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity). During the activation phase, promotes the accumulation of ubiquitinated ARNTL/BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and ARNTL/BMAL1 (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758).	Sumoylated in vitro.	Belongs to the histone deacetylase family. HD type 1 subfamily.	PPARA activates gene expression;HDACs deacetylate histones;Association of TriC/CCT with target proteins during biosynthesis;Notch-HLH transcription pathway;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Transcriptional regulation of white adipocyte differentiation;p75NTR negatively regulates cell cycle via SC1;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);NR1D1 (REV-ERBA) represses gene expression;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Regulation of PTEN gene transcription;RUNX2 regulates osteoblast differentiation;Regulation of MECP2 expression and activity;Loss of MECP2 binding ability to the NCoR/SMRT complex	PE1	5
+NX_O15381	Nuclear valosin-containing protein-like	856	95051	6.11	0	Nucleoplasm;Nucleolus	NA	Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111).	NA	Belongs to the AAA ATPase family.	Ribosome biogenesis in eukaryotes	PE1	1
+NX_O15382	Branched-chain-amino-acid aminotransferase, mitochondrial	392	44288	8.88	0	Cytoplasm;Mitochondrion	NA	Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.	NA	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Valine, leucine and isoleucine degradation;Valine, leucine and isoleucine biosynthesis;Pantothenate and CoA biosynthesis;Metabolic pathways;Branched-chain amino acid catabolism	PE1	19
+NX_O15389	Sialic acid-binding Ig-like lectin 5	551	60715	7.01	1	Membrane	NA	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.	NA	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Neutrophil degranulation	PE1	19
+NX_O15391	Transcription factor YY2	372	41347	5.76	0	Nucleus	NA	Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.	NA	Belongs to the YY transcription factor family.	NA	PE1	X
+NX_O15392	Baculoviral IAP repeat-containing protein 5	142	16389	5.66	0	Kinetochore;Cytoplasm;Chromosome;Midbody;Centromere;Spindle;Nucleus;Cytoskeleton	NA	Do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752).;Shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).;Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684).	In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes (PubMed:14610074). Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities (PubMed:21252625). Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity (PubMed:24866247). Phosphorylation at Ser-20 by AURKC is critical for regulation of proper chromosome alignment and segregation, and possibly cytokinesis.;Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.;Acetylation at Lys-129 by CBP results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.	Belongs to the IAP family.	Pathways in cancer;Colorectal cancer;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;SUMOylation of DNA replication proteins;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Interleukin-4 and Interleukin-13 signaling;Neddylation	PE1	17
+NX_O15393	Transmembrane protease serine 2	492	53859	8.12	1	Nucleoplasm;Cell junction;Secreted;Cell membrane	NA	Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.	Proteolytically processed; by an autocatalytic mechanism.	Belongs to the peptidase S1 family.	Influenza A	PE1	21
+NX_O15394	Neural cell adhesion molecule 2	837	93046	5.44	1	Nucleus;Cell membrane	NA	May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.	NA	NA	Cell adhesion molecules (CAMs);Prion diseases	PE1	21
+NX_O15397	Importin-8	1037	119938	5.04	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.	NA	Belongs to the importin beta family.	Transcriptional regulation by small RNAs	PE1	12
+NX_O15399	Glutamate receptor ionotropic, NMDA 2D	1336	143752	8.68	3	Cell membrane;Postsynaptic cell membrane	Epileptic encephalopathy, early infantile, 46	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750).	NA	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Long-term potentiation;Glutamatergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);RAF/MAP kinase cascade;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;Synaptic adhesion-like molecules;Neurexins and neuroligins;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	19
+NX_O15400	Syntaxin-7	261	29816	5.41	1	Early endosome membrane;Lysosome	NA	May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.	NA	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;Phagosome	PE1	6
+NX_O15403	Monocarboxylate transporter 7	523	57393	7.95	12	Cytoplasmic vesicle;Cell membrane	NA	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	NA	PE1	17
+NX_O15405	TOX high mobility group box family member 3	576	63342	7.36	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.	NA	NA	NA	PE1	16
+NX_O15409	Forkhead box protein P2	715	79919	6.06	0	Nucleoplasm;Nucleus	Speech-language disorder 1	Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.	NA	NA	NA	PE1	7
+NX_O15417	Trinucleotide repeat-containing gene 18 protein	2968	314519	8.88	0	Nucleoplasm;Cytosol;Mitochondrion;Nucleus membrane	NA	NA	NA	NA	NA	PE1	7
+NX_O15427	Monocarboxylate transporter 4	465	49469	8.23	12	Nucleus membrane;Cell membrane	NA	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	Pyruvate metabolism;Basigin interactions;Proton-coupled monocarboxylate transport	PE1	17
+NX_O15428	Putative PIN1-like protein	100	11021	9.59	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_O15431	High affinity copper uptake protein 1	190	21091	6.89	3	Cell membrane	NA	High-affinity, saturable copper transporter involved in dietary copper uptake.	O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain.	Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.	Mineral absorption;Metal ion SLC transporters	PE1	9
+NX_O15432	Probable low affinity copper uptake protein 2	143	15681	6.25	3	Membrane;Nucleus speckle;Cell membrane;Cytoskeleton	NA	Involved in low-affinity copper uptake.	NA	Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.	NA	PE1	9
+NX_O15438	Canalicular multispecific organic anion transporter 2	1527	169343	6.79	17	Membrane;Cell membrane	NA	May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).	NA	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.	ABC transporters;Bile secretion;ABC-family proteins mediated transport;Recycling of bile acids and salts	PE1	17
+NX_O15439	Multidrug resistance-associated protein 4	1325	149527	8.41	14	Membrane;Golgi apparatus;Nucleolus;Cell membrane	NA	May be an organic anion pump relevant to cellular detoxification.	NA	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.	ABC transporters;Bile secretion;Platelet degranulation;ABC-family proteins mediated transport	PE1	13
+NX_O15440	Multidrug resistance-associated protein 5	1437	160660	8.87	13	Membrane;Nucleoplasm;Cell junction;Cell membrane	NA	Acts as a multispecific organic anion pump which can transport nucleotide analogs.	NA	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.	ABC transporters;ABC-family proteins mediated transport;Hyaluronan biosynthesis and export	PE1	3
+NX_O15442	Metallophosphoesterase domain-containing protein 1	326	37207	6.17	0	NA	NA	May have metallophosphoesterase activity (in vitro).	NA	Belongs to the UPF0046 family.	NA	PE2	22
+NX_O15444	C-C motif chemokine 25	150	16609	10.2	0	Secreted	NA	Is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.;Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9.	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Intestinal immune network for IgA production;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	19
+NX_O15446	DNA-directed RNA polymerase I subunit RPA34	510	54986	8.66	0	Nucleoplasm;Mitochondrion;Nucleolus;Chromosome	NA	Has been described as a component of preformed T-cell receptor (TCR) complex.;Is involved in UBTF-activated transcription, presumably at a step following PIC formation.;DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.	Undergoes tyrosine phosphorylation upon T-cell receptor (TCR) stimulation. This phosphorylation has not been confirmed by other groups.;Is phosphorylated on tyrosine residues in initiation-competent Pol I-beta complexes but not in Pol I-alpha complexes.	Belongs to the eukaryotic RPA34 RNA polymerase subunit family.	NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;B-WICH complex positively regulates rRNA expression	PE1	19
+NX_O15455	Toll-like receptor 3	904	103829	6.73	1	Early endosome;Endoplasmic reticulum membrane;Endosome membrane	Encephalopathy, acute, infection-induced, Herpes-specific, 2	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.	Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding.;TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes.	Belongs to the Toll-like receptor family.	Toll-like receptor signaling pathway;Hepatitis C;Influenza A;Herpes simplex infection;RIP-mediated NFkB activation via ZBP1;Trafficking and processing of endosomal TLR;TICAM1 deficiency - HSE;TRAF3 deficiency - HSE;Toll Like Receptor 3 (TLR3) Cascade;TLR3 deficiency - HSE;UNC93B1 deficiency - HSE;TICAM1, RIP1-mediated IKK complex recruitment;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;TLR3-mediated TICAM1-dependent programmed cell death	PE1	4
+NX_O15457	MutS protein homolog 4	936	104756	7.16	0	NA	NA	Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.	NA	Belongs to the DNA mismatch repair MutS family.	Meiotic recombination	PE1	1
+NX_O15460	Prolyl 4-hydroxylase subunit alpha-2	535	60902	5.49	0	Endoplasmic reticulum;Cytoplasmic vesicle;Endoplasmic reticulum lumen	Myopia 25, autosomal dominant	Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.	NA	Belongs to the P4HA family.	Arginine and proline metabolism;Metabolic pathways;Collagen biosynthesis and modifying enzymes	PE1	5
+NX_O15466	Alpha-2,8-sialyltransferase 8E	376	43895	9.19	1	Cell membrane;Midbody;Golgi apparatus membrane	NA	May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively.	NA	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Sialic acid metabolism	PE1	18
+NX_O15467	C-C motif chemokine 16	120	13600	9.61	0	Secreted	NA	Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	17
+NX_O15479	Melanoma-associated antigen B2	319	35277	8.87	0	Cytosol	NA	May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.	NA	NA	NA	PE1	X
+NX_O15480	Melanoma-associated antigen B3	346	39211	10.07	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_O15481	Melanoma-associated antigen B4	346	38923	9.28	0	Cytoplasm	NA	NA	NA	NA	NA	PE1	X
+NX_O15482	Testis-specific protein TEX28	410	46131	5.86	1	Membrane	NA	NA	NA	Belongs to the TEX28 family.	NA	PE1	X
+NX_O15484	Calpain-5	640	73169	7.57	0	Nucleoplasm;Cytosol	Vitreoretinopathy, neovascular inflammatory	Calcium-regulated non-lysosomal thiol-protease.	NA	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	11
+NX_O15488	Glycogenin-2	501	55184	4.97	0	Nucleoplasm;Cytosol;Nucleolus	NA	Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.	Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-228.	Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.	Glycan biosynthesis; glycogen biosynthesis.;Glycogen synthesis;Glycogen breakdown (glycogenolysis);Glycogen storage disease type 0 (liver GYS2);Glycogen storage disease type IV (GBE1)	PE1	X
+NX_O15492	Regulator of G-protein signaling 16	202	22749	6.18	0	Membrane;Cytosol	NA	Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity).	Phosphorylated. Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1.;Palmitoylated on Cys-2 and/or Cys-12.	NA	G alpha (i) signalling events;G alpha (q) signalling events;G alpha (z) signalling events	PE1	1
+NX_O15496	Group 10 secretory phospholipase A2	165	18153	6.07	0	Secreted	NA	PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.	NA	Belongs to the phospholipase A2 family.	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI	PE1	16
+NX_O15498	Synaptobrevin homolog YKT6	198	22418	6.44	0	Cytoplasmic vesicle membrane;Cytosol;Mitochondrion;Golgi apparatus membrane	NA	Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.	Farnesylation is required for Golgi targeting.;Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.	Belongs to the synaptobrevin family.	SNARE interactions in vesicular transport;COPII-mediated vesicle transport;Intra-Golgi traffic;COPI-mediated anterograde transport	PE1	7
+NX_O15499	Homeobox protein goosecoid-2	205	21545	10.58	0	Nucleus	NA	May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC.	NA	Belongs to the paired homeobox family. Bicoid subfamily.	NA	PE2	22
+NX_O15503	Insulin-induced gene 1 protein	277	29987	9.08	6	Cytoplasmic vesicle;Endoplasmic reticulum membrane	NA	Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.	Ubiquitinated. Subsequent to sterol deprivation, the SCAP-SREBF2 complex becomes dissociated from INSIG1, is then ubiquitinated and degraded in proteasomes. Although ubiquitination is required for rapid INSIG1 degradation, it is not required for release of the SCAP-SREBP complex. Ubiquitinated by RNF139.	Belongs to the INSIG family.	Regulation of cholesterol biosynthesis by SREBP (SREBF)	PE1	7
+NX_O15504	Nucleoporin NUP42	423	44872	9.25	0	Nucleoplasm;Nucleus membrane;Nuclear pore complex	NA	Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.;(Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope.	O-glycosylated.	NA	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	7
+NX_O15511	Actin-related protein 2/3 complex subunit 5	151	16320	5.47	0	Cell membrane;Cell junction;Cell projection;Cytoplasmic vesicle;Cytosol;Nucleus;Cytoskeleton	NA	Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).	Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.	Belongs to the ARPC5 family.	Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;EPHB-mediated forward signaling;Clathrin-mediated endocytosis;Neutrophil degranulation	PE1	1
+NX_O15514	DNA-directed RNA polymerase II subunit RPB4	142	16311	4.75	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).	NA	Belongs to the eukaryotic RPB4 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Huntington's disease;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;MicroRNA (miRNA) biogenesis;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	2
+NX_O15516	Circadian locomoter output cycles protein kaput	846	95304	6.51	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner ARNTL/BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity).	Phosphorylation is dependent on the CLOCK-ARNTL/BMAL1 heterodimer formation. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver. May be phosphorylated by CSNK1D and CKSN1E.;Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.;Ubiquitinated, leading to its proteasomal degradation.;Sumoylation enhances its transcriptional activity and interaction with ESR1, resulting in up-regulation of ESR1 activity. Estrogen stimulates sumoylation. Desumoylation by SENP1 negatively regulates its transcriptional activity. Sumoylation stimulates cell proliferation and increases the proportion of S phase cells in breast cancer cell lines.;O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-ARNTL/BMAL1 heterodimer thereby increasing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2/3 and CRY1/2.	NA	Circadian rhythm - mammal;Dopaminergic synapse;Herpes simplex infection;HATs acetylate histones;PPARA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock	PE1	4
+NX_O15519	CASP8 and FADD-like apoptosis regulator	480	55344	8.19	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.	Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.;CFLAR is phosphorylated by PRKCE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the peptidase C14A family.	Apoptosis;Chagas disease (American trypanosomiasis);Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TRAIL signaling	PE1	2
+NX_O15520	Fibroblast growth factor 10	208	23436	9.61	0	Secreted	Aplasia of lacrimal and salivary glands;Lacrimo-auriculo-dento-digital syndrome	Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;FGFR2b ligand binding and activation;PI3K Cascade;PIP3 activates AKT signaling;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Signaling by FGFR2 in disease;Regulation of gene expression in early pancreatic precursor cells;FGFR1b ligand binding and activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;FGFRL1 modulation of FGFR1 signaling	PE1	5
+NX_O15522	Homeobox protein Nkx-2.8	239	25866	9.47	0	Nucleoplasm;Nucleus;Cell membrane	NA	NA	NA	Belongs to the NK-2 homeobox family.	NA	PE1	14
+NX_O15523	ATP-dependent RNA helicase DDX3Y	660	73154	7.24	0	Cytoplasm;Nucleus	NA	Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.	NA	Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	RIG-I-like receptor signaling pathway	PE1	Y
+NX_O15524	Suppressor of cytokine signaling 1	211	23551	10.98	0	Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.	SOCS1 is phosphorylated by PIM1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SOCS1 is phosphorylated by PIM3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SOCS1 is phosphorylated by PIM2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the SOCS1 family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Osteoclast differentiation;Jak-STAT signaling pathway;Insulin signaling pathway;Type II diabetes mellitus;Toxoplasmosis;Antigen processing: Ubiquitination & Proteasome degradation;Interferon gamma signaling;Interferon alpha/beta signaling;Interleukin-7 signaling;Regulation of IFNA signaling;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Growth hormone receptor signaling;Regulation of KIT signaling;Regulation of IFNG signaling;Interleukin-4 and Interleukin-13 signaling	PE1	16
+NX_O15525	Transcription factor MafG	162	17850	10.04	0	Nucleus	NA	Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity).	Sumoylation at Lys-14 is required for active transcriptional repression.;Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.	Belongs to the bZIP family. Maf subfamily.	Factors involved in megakaryocyte development and platelet production	PE1	17
+NX_O15527	N-glycosylase/DNA lyase	345	38782	8.89	0	Nucleus speckle;Mitochondrion;Nucleus matrix;Nucleoplasm;Nucleus	Renal cell carcinoma	DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.	NA	Belongs to the type-1 OGG1 family.	Base excision repair;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Displacement of DNA glycosylase by APEX1;APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine	PE1	3
+NX_O15528	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	508	56504	9.34	0	Mitochondrion membrane	Rickets vitamin D-dependent 1A	Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)(2)D3), and of 24,25-dihydroxyvitamin D3 (24,25(OH)(2)D3) to 1-alpha,24,25-trihydroxyvitamin D3 (1alpha,24,25(OH)(3)D3). Is also active with 25-hydroxy-24-oxo-vitamin D3. Plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.	NA	Belongs to the cytochrome P450 family.	Hormone biosynthesis; cholecalciferol biosynthesis.;Steroid biosynthesis;Metabolic pathways;Tuberculosis;Vitamin D (calciferol) metabolism;Vitamins;Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)	PE1	12
+NX_O15529	G-protein coupled receptor 42	346	38695	7.55	7	Cell membrane	NA	Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	19
+NX_O15530	3-phosphoinositide-dependent protein kinase 1	556	63152	6.95	0	Cytoplasm;Cell membrane;Focal adhesion;Cytoplasmic vesicle;Nucleus	NA	Is catalytically inactive.;Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages.	Monoubiquitinated in the kinase domain, deubiquitinated by USP4.;Autophosphorylated; autophosphorylation is inhibited by the apoptotic C-terminus cleavage product of PKN2.;Phosphorylation on Ser-241 in the activation loop is required for full activity. PDPK1 itself can autophosphorylate Ser-241, leading to its own activation. Autophosphorylation is inhibited by the apoptotic C-terminus cleavage product of PKN2 (By similarity). Tyr-9 phosphorylation is critical for stabilization of both PDPK1 and the PDPK1/SRC complex via HSP90-mediated protection of PDPK1 degradation. Angiotensin II stimulates the tyrosine phosphorylation of PDPK1 in vascular smooth muscle in a calcium- and SRC-dependent manner. Phosphorylated on Tyr-9, Tyr-373 and Tyr-376 by INSR in response to insulin. Palmitate negatively regulates autophosphorylation at Ser-241 and palmitate-induced phosphorylation at Ser-529 and Ser-501 by PKC/PRKCQ negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylation at Thr-354 by MELK partially inhibits kinase activity, the inhibition is cooperatively enhanced by phosphorylation at Ser-394 and Ser-398 by MAP3K5.;PDPK1 is phosphorylated by INSR (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.	PPAR signaling pathway;mTOR signaling pathway;Focal adhesion;Insulin signaling pathway;Aldosterone-regulated sodium reabsorption;Endometrial cancer;Prostate cancer;Non-small cell lung cancer;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Downstream TCR signaling;PIP3 activates AKT signaling;Role of LAT2/NTAL/LAB on calcium mobilization;GPVI-mediated activation cascade;G beta:gamma signalling through PI3Kgamma;VEGFR2 mediated vascular permeability;CD28 dependent PI3K/Akt signaling;Constitutive Signaling by AKT1 E17K in Cancer;RSK activation;Activation of AKT2;Integrin alphaIIb beta3 signaling;VEGFR2 mediated cell proliferation;RHO GTPases activate PKNs;Regulation of TP53 Degradation;Estrogen-stimulated signaling through PRKCZ	PE1	16
+NX_O15533	Tapasin	448	47626	6.68	1	Endoplasmic reticulum membrane	Bare lymphocyte syndrome 1	Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).	NA	NA	Antigen processing and presentation;ER-Phagosome pathway;Antigen Presentation: Folding, assembly and peptide loading of class I MHC	PE1	6
+NX_O15534	Period circadian protein homolog 1	1290	136212	5.73	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1.	Ubiquitinated; requires phosphorylation by CSNK1E and interaction with BTRC and FBXW11. Deubiquitinated by USP2 (By similarity).;Phosphorylated on serine residues by CSNK1D, CSNK1E and probably also by CSNK1G2. Phosphorylation by CSNK1D or CSNK1E promotes nuclear location of PER proteins as well as ubiquitination and subsequent degradation. May be dephosphorylated by PP1.	NA	Circadian rhythm - mammal;Herpes simplex infection;Circadian Clock	PE1	17
+NX_O15535	Zinc finger and SCAN domain-containing protein 9	394	45954	6.94	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_O15537	Retinoschisin	224	25592	5.51	0	Secreted;Cell membrane	Retinoschisis juvenile X-linked 1	Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009).	NA	NA	NA	PE1	X
+NX_O15539	Regulator of G-protein signaling 5	181	20946	6.85	0	Membrane;Cytoplasm;Nucleus	NA	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).	NA	NA	G alpha (i) signalling events;G alpha (q) signalling events	PE1	1
+NX_O15540	Fatty acid-binding protein, brain	132	14889	5.4	0	Nucleoplasm;Golgi apparatus;Cytosol;Cytoplasm	NA	B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	PPAR signaling pathway;Triglyceride catabolism;NOTCH3 Intracellular Domain Regulates Transcription	PE1	6
+NX_O15541	E3 ubiquitin-protein ligase RNF113A	343	38787	5.51	0	Nucleoplasm;Nucleus speckle;Nucleus	Trichothiodystrophy 5, non-photosensitive	Required for pre-mRNA splicing as component of the spliceosome (PubMed:29361316, PubMed:29360106). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524).	NA	NA	Protein modification; protein ubiquitination.	PE1	X
+NX_O15544	Protein GR6	149	16056	6.27	0	NA	NA	NA	NA	NA	NA	PE2	3
+NX_O15547	P2X purinoceptor 6	441	48829	7.52	2	Membrane;Cytosol;Nucleolus	NA	Receptor for ATP that acts as a ligand-gated ion channel.	N-glycosylated.	Belongs to the P2X receptor family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Elevation of cytosolic Ca2+ levels;Platelet homeostasis	PE1	22
+NX_O15550	Lysine-specific demethylase 6A	1401	154177	7.17	0	Nucleus	Kabuki syndrome 2	Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity).	NA	Belongs to the UTX family.	HDMs demethylate histones;Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	X
+NX_O15551	Claudin-3	220	23319	8.37	4	Tight junction;Cell junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	7
+NX_O15552	Free fatty acid receptor 2	330	37144	9.5	7	Cell membrane	NA	G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604). Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016).	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (q) signalling events;Free fatty acid receptors	PE1	19
+NX_O15553	Pyrin	781	86444	8.3	0	Cytoplasm;Nucleoplasm;Lamellipodium;Autophagosome;Ruffle;Cytosol;Nucleus;Cytoskeleton	Familial Mediterranean fever, autosomal recessive;Familial Mediterranean fever, autosomal dominant	Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production (PubMed:16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923).	Cleaved by CASP1 (Probable). The N-terminal cleavage product localizes to the nucleus as a filamentous network and to the cytoplasm, interacts more strongly with RELA and NFKBIA than the full-length protein, enhances the nuclear localization of RELA and induces NFKBIA proteolysis. The C-terminal cleavage product localizes to the cytoplasm.	NA	NOD-like receptor signaling pathway;The NLRP3 inflammasome	PE1	16
+NX_O15554	Intermediate conductance calcium-activated potassium channel protein 4	427	47696	9.87	6	Cell membrane	Dehydrated hereditary stomatocytosis 2	Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580).	Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel.	Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.	Salivary secretion;Protein digestion and absorption;Ca2+ activated K+ channels	PE1	19
+NX_O42043	Endogenous retrovirus group K member 18 Env polyprotein	560	63671	7.83	1	Virion;Cell membrane	NA	TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).;SU mediates receptor recognition.;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This envelope protein has superantigenic properties.	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.	NA	PE1	1
+NX_O43143	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15	795	90933	7.12	0	Nucleolus;Nucleus speckle;Nucleus	NA	Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.	NA	Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.	Spliceosome;mRNA Splicing - Major Pathway	PE1	4
+NX_O43147	Small G protein signaling modulator 2	1006	113285	6.2	0	Cytoplasm;Nucleoplasm;Melanosome;Cytosol	NA	Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560).	NA	Belongs to the RUTBC family.	NA	PE1	17
+NX_O43148	mRNA cap guanine-N7 methyltransferase	476	54844	6.29	0	Nucleoplasm;Nucleus;Nucleolus	NA	Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.	mRNA surveillance pathway;mRNA Capping;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;RNA Pol II CTD phosphorylation and interaction with CE	PE1	18
+NX_O43149	Zinc finger ZZ-type and EF-hand domain-containing protein 1	2961	331075	5.62	0	Nucleoplasm;Mitochondrion	NA	NA	NA	NA	NA	PE1	17
+NX_O43150	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2	1006	111651	6.24	0	Golgi stack membrane;Cytoplasm;Cytosol;Cell membrane	NA	Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.	Phosphorylated on tyrosine residues by SRC and PTK2B.;ASAP2 is phosphorylated by PTK2B (Phosphotyrosine:PTM-0255)	NA	Endocytosis;Fc gamma R-mediated phagocytosis	PE1	2
+NX_O43151	Methylcytosine dioxygenase TET3	1660	179350	7.01	0	Cytoplasm;Chromosome;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes (PubMed:23217707). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT (PubMed:23353889).	NA	Belongs to the TET family.	TET1,2,3 and TDG demethylate DNA	PE1	2
+NX_O43155	Leucine-rich repeat transmembrane protein FLRT2	660	74049	7.88	1	Microsome membrane;Endoplasmic reticulum membrane;Extracellular matrix;Synaptosome;Cell membrane;Focal adhesion;Secreted	NA	Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.	Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.;N-glycosylated.	NA	Downstream signaling of activated FGFR1	PE1	14
+NX_O43156	TELO2-interacting protein 1 homolog	1089	122069	5.63	0	Nucleoplasm;Cytoplasm;Cytoplasmic vesicle	NA	Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.	Phosphorylated at Ser-828 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2; leading to selective ubiquitination of mTORC1-associated protein.;Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.	Belongs to the tti1 family.	NA	PE1	20
+NX_O43157	Plexin-B1	2135	232298	5.29	1	Secreted;Cell membrane	NA	Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496).	Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.;Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.	Belongs to the plexin family.	Axon guidance;G alpha (12/13) signalling events;Sema4D mediated inhibition of cell attachment and migration;Sema4D induced cell migration and growth-cone collapse	PE1	3
+NX_O43159	Ribosomal RNA-processing protein 8	456	50715	9.51	0	Nucleoplasm;Cytosol;Nucleolus	NA	Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.	NA	Belongs to the methyltransferase superfamily. RRP8 family.	SIRT1 negatively regulates rRNA expression	PE1	11
+NX_O43164	E3 ubiquitin-protein ligase Praja-2	708	78214	4.28	0	Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Postsynaptic density;Synapse;Golgi apparatus membrane;Cytoskeleton	NA	Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450).	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination & Proteasome degradation	PE1	5
+NX_O43166	Signal-induced proliferation-associated 1-like protein 1	1804	200029	8.4	0	Cell membrane;Synaptosome;Postsynaptic density;Cytoskeleton	NA	Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).	Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2.;Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity).	NA	Neurexins and neuroligins	PE1	14
+NX_O43167	Zinc finger and BTB domain-containing protein 24	697	78282	7.42	0	Nucleoplasm;Centrosome;Nucleus;Cytoskeleton	Immunodeficiency-centromeric instability-facial anomalies syndrome 2	May be involved in BMP2-induced transcription.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_O43169	Cytochrome b5 type B	150	16695	4.88	1	Mitochondrion outer membrane;Endoplasmic reticulum;Cytosol;Centriolar satellite	NA	Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.	NA	Belongs to the cytochrome b5 family.	Phase I - Functionalization of compounds	PE1	16
+NX_O43172	U4/U6 small nuclear ribonucleoprotein Prp4	522	58449	7.05	0	Nucleus speckle;Nucleus	Retinitis pigmentosa 70	Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).	NA	NA	Spliceosome;mRNA Splicing - Major Pathway	PE1	9
+NX_O43173	Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase	380	43970	9.56	1	Golgi apparatus;Golgi apparatus membrane	NA	Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.	NA	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Sialic acid metabolism;N-Glycan antennae elongation	PE1	18
+NX_O43174	Cytochrome P450 26A1	497	56199	8.96	0	Microsome membrane;Endoplasmic reticulum membrane	NA	Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.;Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.	NA	Belongs to the cytochrome P450 family.	Retinol metabolism;RA biosynthesis pathway;Vitamins	PE1	10
+NX_O43175	D-3-phosphoglycerate dehydrogenase	533	56650	6.29	0	Nucleoplasm;Cytosol;Cell membrane	Phosphoglycerate dehydrogenase deficiency;Neu-Laxova syndrome 1	Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.	NA	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.;Glycine, serine and threonine metabolism;Metabolic pathways;Serine biosynthesis	PE1	1
+NX_O43181	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	175	20108	10.3	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 1	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFS4 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	5
+NX_O43182	Rho GTPase-activating protein 6	974	105947	7	0	Cytoplasm;Cytosol	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.	NA	NA	Rho GTPase cycle	PE1	X
+NX_O43184	Disintegrin and metalloproteinase domain-containing protein 12	909	99542	8.79	1	Secreted;Cell membrane	NA	Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).	The precursor is cleaved by a furin endopeptidase.	NA	Signaling by EGFR;Invadopodia formation	PE1	10
+NX_O43186	Cone-rod homeobox protein	299	32261	9.23	0	Nucleus	Leber congenital amaurosis 7;Cone-rod dystrophy 2;Retinitis pigmentosa	Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.	NA	Belongs to the paired homeobox family.	NA	PE1	19
+NX_O43187	Interleukin-1 receptor-associated kinase-like 2	625	69433	5.51	0	Cytoplasmic vesicle	NA	Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.	IRAK2 is phosphorylated by IRAK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.	Apoptosis;Neurotrophin signaling pathway;Tuberculosis;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 dependent cascade initiated on endosome;MyD88 cascade initiated on plasma membrane;TRAF6-mediated induction of TAK1 complex within TLR4 complex;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;IRAK2 mediated activation of TAK1 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Interleukin-1 signaling	PE1	3
+NX_O43189	PHD finger protein 1	567	62106	9.27	0	Nucleoplasm;Centrosome;Nucleus	NA	Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.	NA	Belongs to the Polycomblike family.	PRC2 methylates histones and DNA	PE1	6
+NX_O43193	Motilin receptor	412	45344	9.97	7	Cell membrane	NA	Receptor for motilin.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events	PE2	13
+NX_O43194	G-protein coupled receptor 39	453	51329	9.43	7	Cell membrane	NA	Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (q) signalling events;Class A/1 (Rhodopsin-like receptors);G alpha (s) signalling events	PE1	2
+NX_O43196	MutS protein homolog 5	834	92875	5.95	0	Endoplasmic reticulum;Cytoplasmic vesicle	Premature ovarian failure 13	Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity).	NA	Belongs to the DNA mismatch repair MutS family.	Meiotic recombination	PE1	6
+NX_O43236	Septin-4	478	55098	5.77	0	Cytoplasm;Mitochondrion;Nucleoplasm;Flagellum;Nucleus;Cytoskeleton	NA	Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in platelet secretion.;But not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.	SEPT4 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	Release of apoptotic factors from the mitochondria;SMAC, XIAP-regulated apoptotic response	PE1	17
+NX_O43237	Cytoplasmic dynein 1 light intermediate chain 2	492	54099	5.97	0	Cytosol;Centrosome;Cytoskeleton	NA	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	NA	Belongs to the dynein light intermediate chain family.	Phagosome;Vasopressin-regulated water reabsorption;Salmonella infection;Separation of Sister Chromatids;MHC class II antigen presentation;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	16
+NX_O43240	Kallikrein-10	276	30170	8.95	0	Secreted	NA	Has a tumor-suppressor role for NES1 in breast and prostate cancer.	NA	Belongs to the peptidase S1 family. Kallikrein subfamily.	NA	PE1	19
+NX_O43242	26S proteasome non-ATPase regulatory subunit 3	534	60978	8.47	0	Nucleoplasm;Cytosol	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.	NA	Belongs to the proteasome subunit S3 family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination & Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	17
+NX_O43246	Cationic amino acid transporter 4	635	68268	6.59	13	Membrane	NA	Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.	NA	PE1	22
+NX_O43247	Testis-expressed protein 33	280	30725	7.77	0	NA	NA	NA	NA	NA	NA	PE1	22
+NX_O43248	Homeobox protein Hox-C11	304	33748	8.81	0	Nucleoplasm;Cytosol;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	12
+NX_O43251	RNA binding protein fox-1 homolog 2	390	41374	6.71	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.	RBFOX2 is phosphorylated by MAPK3	NA	FGFR2 alternative splicing	PE1	22
+NX_O43252	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1	624	70833	6.4	0	Nucleoplasm;Nucleolus	NA	Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487).	NA	In the N-terminal section; belongs to the APS kinase family.;In the C-terminal section; belongs to the sulfate adenylyltransferase family.	Sulfur metabolism; sulfate assimilation.;Purine metabolism;Selenocompound metabolism;Sulfur metabolism;Metabolic pathways;Transport and synthesis of PAPS;Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;Signaling by BRAF and RAF fusions	PE1	4
+NX_O43255	E3 ubiquitin-protein ligase SIAH2	324	34615	6.71	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA. Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation. Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558).	Phosphorylated at Ser-28 by MAPK14, which mediates the degradation by the proteasome of EGLN3 (By similarity). Phosphorylated at Ser-28 by DYRK2; this increases the ubiquitin ligase activity and promotes degradation of EGLN3.	Belongs to the SINA (Seven in absentia) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination & Proteasome degradation;Amyloid fiber formation;Netrin-1 signaling;Ub-specific processing proteases	PE1	3
+NX_O43257	Zinc finger HIT domain-containing protein 1	154	17536	9.55	0	Nucleoplasm;Nucleus	NA	Seems to play a role in p53-mediated apoptosis induction (PubMed:17380123). Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity (PubMed:17892483).	Stres-induced ZNHIT1 is mainly regulated at the level of protein.;Phosphorylated on Thr by MAPK11 or MAPK14.;ZNHIT1 is phosphorylated by MAPK11 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the ZNHIT1 family.	NA	PE1	7
+NX_O43261	Leukemia-associated protein 1	78	8962	5.14	0	NA	NA	May act as a tumor suppressor.	NA	NA	NA	PE1	13
+NX_O43264	Centromere/kinetochore protein zw10 homolog	779	88829	5.89	0	Cytoplasm;Endoplasmic reticulum membrane;Endoplasmic reticulum;Cytosol;Spindle;Kinetochore	NA	Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241).	NA	Belongs to the ZW10 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-dependent Golgi-to-ER retrograde traffic	PE1	11
+NX_O43272	Proline dehydrogenase 1, mitochondrial	600	68002	7.96	0	Mitochondrion matrix	Hyperprolinemia 1;Schizophrenia 4	Converts proline to delta-1-pyrroline-5-carboxylate.	NA	Belongs to the proline oxidase family.	Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.;Arginine and proline metabolism;Metabolic pathways;Proline catabolism	PE1	22
+NX_O43278	Kunitz-type protease inhibitor 1	529	58398	5.89	0	Nucleoplasm;Cytosol;Secreted;Cell membrane	NA	Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).	NA	NA	Signaling by MST1;MET Receptor Activation	PE1	15
+NX_O43280	Trehalase	583	66568	5.46	0	Cell membrane	Trehalase deficiency	Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.	NA	Belongs to the glycosyl hydrolase 37 family.	Starch and sucrose metabolism;Digestion of dietary carbohydrate	PE1	11
+NX_O43281	Embryonal Fyn-associated substrate	561	58815	4.98	0	Nucleoplasm;Cytosol	NA	Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity).	Phosphorylated on multiple tyrosine residues. Phosphorylated on tyrosines by FYN and SRC (By similarity).	Belongs to the CAS family.	NA	PE1	14
+NX_O43283	Mitogen-activated protein kinase kinase kinase 13	966	108296	6.05	0	Cytoplasm;Centriolar satellite;Membrane;Nucleoplasm;Cytosol	NA	Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.	Autophosphorylated on serine and threonine residues.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway	PE1	3
+NX_O43286	Beta-1,4-galactosyltransferase 5	388	45119	8.21	1	Golgi stack membrane;Golgi apparatus	NA	Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity).	NA	Belongs to the glycosyltransferase 7 family.	Sphingolipid metabolism.;Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;O-linked glycosylation of mucins;Keratan sulfate biosynthesis;N-Glycan antennae elongation	PE1	20
+NX_O43290	U4/U6.U5 tri-snRNP-associated protein 1	800	90255	5.89	0	Golgi apparatus;Nucleus speckle;Nucleus	NA	Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.	Sumoylated with SUMO2.	Belongs to the SNU66/SART1 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	11
+NX_O43291	Kunitz-type protease inhibitor 2	252	28228	8.68	1	Membrane;Cytosol;Cell membrane;Cytoskeleton	Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies	Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.	NA	NA	Signaling by MST1;MET Receptor Activation	PE1	19
+NX_O43292	Glycosylphosphatidylinositol anchor attachment 1 protein	621	67623	8.15	7	Endoplasmic reticulum membrane	Glycosylphosphatidylinositol biosynthesis defect 15	Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.	NA	NA	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Attachment of GPI anchor to uPAR	PE1	8
+NX_O43293	Death-associated protein kinase 3	454	52536	6.44	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor.;Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton.	The phosphorylation status is critical for kinase activity, oligomerization and intracellular localization. Phosphorylation at Thr-180, Thr-225 and Thr-265 is essential for activity. The phosphorylated form is localized in the cytoplasm promoted by phosphorylation at Thr-299; nuclear translocation or retention is maximal when it is not phosphorylated. Phosphorylation increases the trimeric form, and its dephosphorylation favors a kinase-inactive monomeric form. Both isoform 1 and isoform 2 can undergo autophosphorylation.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.	Pathways in cancer;Bladder cancer;Caspase activation via Dependence Receptors in the absence of ligand	PE1	19
+NX_O43294	Transforming growth factor beta-1-induced transcript 1 protein	461	49814	6.62	0	Cytosol;Nucleus matrix;Focal adhesion;Cytoskeleton	NA	Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.	Phosphorylated by gonadotropin-releasing hormone-activated SRC.;TGFB1I1 is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	Belongs to the paxillin family.	NA	PE1	16
+NX_O43295	SLIT-ROBO Rho GTPase-activating protein 3	1099	124504	6.23	0	NA	NA	GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.	NA	NA	Axon guidance;Rho GTPase cycle;Inactivation of CDC42 and RAC1	PE1	3
+NX_O43296	Zinc finger protein 264	627	70587	7.36	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_O43298	Zinc finger and BTB domain-containing protein 43	467	52630	5.46	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	9
+NX_O43299	AP-5 complex subunit zeta-1	807	88605	6.57	0	Cytoplasm;Nucleoplasm;Nucleus speckle;Nucleus	Spastic paraplegia 48, autosomal recessive	As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair.	NA	NA	NA	PE1	7
+NX_O43300	Leucine-rich repeat transmembrane neuronal protein 2	516	59076	8.27	1	Cell membrane;Postsynaptic cell membrane	NA	Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).	NA	Belongs to the LRRTM family.	Neurexins and neuroligins	PE1	5
+NX_O43301	Heat shock 70 kDa protein 12A	675	74978	6.32	0	Golgi apparatus;Cytoplasm;Cytosol;Nucleus	NA	Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization.	NA	Belongs to the heat shock protein 70 family.	Regulation of HSF1-mediated heat shock response	PE1	10
+NX_O43303	Centriolar coiled-coil protein of 110 kDa	1012	113424	8.83	0	Centrosome;Cilium basal body;Centriole	NA	Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).	Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate.;Phosphorylated by CDKs.	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2;Ub-specific processing proteases	PE1	16
+NX_O43304	SEC14-like protein 5	696	78942	6.08	0	Golgi apparatus;Cytosol	NA	NA	NA	NA	NA	PE1	16
+NX_O43306	Adenylate cyclase type 6	1168	130615	8.56	12	Stereocilium;Golgi apparatus;Cilium;Cell membrane	Lethal congenital contracture syndrome 8	Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity).	Phosphorylation by RAF1 increases enzyme activity. Phosphorylation by PKA at Ser-662 inhibits the GNAS-mediated increase in catalytic activity. Phosphorylation by PKC at Ser-556, Ser-662 and Thr-919 inhibits catalytic activity.	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Chemokine signaling pathway;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Taste transduction;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Vasopressin-regulated water reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;HTLV-I infection;Dilated cardiomyopathy;G alpha (i) signalling events;G alpha (s) signalling events;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (z) signalling events;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway	PE1	12
+NX_O43307	Rho guanine nucleotide exchange factor 9	516	60982	5.47	0	Cytoplasm;Cytosol;Postsynaptic density	Epileptic encephalopathy, early infantile, 8	Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity).	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;GABA receptor activation	PE1	X
+NX_O43309	Zinc finger and SCAN domain-containing protein 12	604	70222	6.28	0	Cytosol;Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_O43310	CBP80/20-dependent translation initiation factor	598	67587	6.1	0	Cytosol;Perinuclear region	NA	Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD).	NA	Belongs to the CTIF family.	NA	PE1	18
+NX_O43312	Protein MTSS 1	755	82251	6.47	0	Cytosol;Cytoskeleton;Cell membrane	NA	May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.	NA	Belongs to the MTSS family.	NA	PE1	8
+NX_O43313	ATM interactor	823	88348	5.02	0	Nucleus	NA	Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.	NA	NA	NA	PE1	16
+NX_O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	1243	140407	8.47	0	Cytoplasmic vesicle;Cytosol	Deafness, autosomal recessive, 100	Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114).	NA	Belongs to the histidine acid phosphatase family. VIP1 subfamily.	Synthesis of pyrophosphates in the cytosol	PE1	5
+NX_O43315	Aquaporin-9	295	31431	7.67	6	Cell membrane	NA	Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines.	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family.	Bile secretion;Transport of glycerol from adipocytes to the liver by Aquaporins;Passive transport by Aquaporins	PE1	15
+NX_O43316	Paired box protein Pax-4	350	37833	9.42	0	Nucleus	Diabetes mellitus, insulin-dependent;Diabetes mellitus, non-insulin-dependent;Diabetes mellitus, ketosis-prone;Maturity-onset diabetes of the young 9	Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site.;Appears to be a dominant negative form antagonizing PAX4 transcriptional activity.	NA	Belongs to the paired homeobox family.	Maturity onset diabetes of the young;Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	PE1	7
+NX_O43318	Mitogen-activated protein kinase kinase kinase 7	606	67196	6.69	0	Cytoplasm;Cytosol;Nucleus speckle;Cell membrane	Frontometaphyseal dysplasia 2;Cardiospondylocarpofacial syndrome	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.	'Lys-48'-linked polyubiquitination at Lys-72 is induced by TNFalpha, and leads to proteasomal degradation. Undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH (By similarity). Requires 'Lys-63'-linked polyubiquitination for autophosphorylation and subsequent activation. 'Lys-63'-linked ubiquitination does not lead to proteasomal degradation. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains. Deubiquitinated by Y.enterocolitica YopP.;Association with TAB1/MAP3K7IP1 promotes autophosphorylation at Ser-192 and subsequent activation. Association with TAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Ser-192 by PPM1B/PP2CB and at Thr-187 by PP2A and PPP6C leads to inactivation.;MAP3K7 is phosphorylated by PINK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP3K7 is phosphorylated by CAMK2A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway;Wnt signaling pathway;Osteoclast differentiation;Adherens junction;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;T cell receptor signaling pathway;Leishmaniasis;Toxoplasmosis;Measles;Herpes simplex infection;Activation of NF-kappaB in B cells;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Downstream TCR signaling;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Ca2+ pathway;TRAF6-mediated induction of TAK1 complex within TLR4 complex;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;IRAK2 mediated activation of TAK1 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling	PE1	6
+NX_O43320	Fibroblast growth factor 16	207	23759	9.22	0	Secreted	Metacarpal 4-5 fusion	Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR3;FGFR4 ligand binding and activation;FGFR3c ligand binding and activation;FGFR2c ligand binding and activation;FGFR3 mutant receptor activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;Phospholipase C-mediated cascade, FGFR4;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by FGFR3 point mutants in cancer	PE1	X
+NX_O43323	Desert hedgehog protein	396	43577	9.4	0	Cell membrane;Extracellular space	46,XY sex reversal 7;Partial gonadal dysgenesis with minifascicular neuropathy 46,XY	Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.	The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). This covalent modification appears to play an essential role in restricting the spatial distribution of the protein activity to the cell surface. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity (By similarity).	Belongs to the hedgehog family.	Hedgehog signaling pathway;Hedgehog ligand biogenesis;Hedgehog 'on' state;Class B/2 (Secretin family receptors);Activation of SMO;Release of Hh-Np from the secreting cell;Ligand-receptor interactions;HHAT G278V abrogates palmitoylation of Hh-Np	PE1	12
+NX_O43324	Eukaryotic translation elongation factor 1 epsilon-1	174	19811	8.55	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Positive modulator of ATM response to DNA damage.	NA	NA	Cytosolic tRNA aminoacylation;Selenoamino acid metabolism	PE1	6
+NX_O43325	LYR motif-containing protein 1	122	14282	9.95	0	Midbody;Nucleoplasm;Nucleus	NA	May promote cell proliferation and inhibition of apoptosis of preadipocytes.	NA	Belongs to the complex I LYR family.	NA	PE1	16
+NX_O43345	Zinc finger protein 208	1280	147487	9.2	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_O43347	RNA-binding protein Musashi homolog 1	362	39125	7.7	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).	NA	Belongs to the Musashi family.	mRNA surveillance pathway;Regulation of expression of SLITs and ROBOs	PE1	12
+NX_O43353	Receptor-interacting serine/threonine-protein kinase 2	540	61195	6.63	0	Cytoplasm;Cytosol	NA	Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181).	Autophosphorylated. Autophosphorylation at Tyr-474 is necessary for effective NOD2 signaling. Phosphorylated. Phosphorylation at Tyr-381 by Src kinase CSK occurs in a ARHGEF2-dependent manner and is required for NOD2-dependent innate immune activation.;Ubiquitinated on Lys-209; undergoes 'Lys-63'-linked polyubiquitination catalyzed by ITCH. Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. Also undergoes 'Met-1'-linked polyubiquitination; the head-to-tail linear polyubiquitination is mediated by the LUBAC complex in response to NOD2 stimulation. Linear polyubiquitination is restricted by FAM105B/otulin, probably to limit NOD2-dependent proinflammatory signaling activation of NF-kappa-B.;RIPK2 is phosphorylated by RAF1	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	NOD-like receptor signaling pathway;Neurotrophin signaling pathway;Shigellosis;Tuberculosis;Downstream TCR signaling;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;p75NTR recruits signalling complexes;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Ovarian tumor domain proteases;Interleukin-1 signaling	PE1	8
+NX_O43361	Zinc finger protein 749	778	90364	9.01	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_O43364	Homeobox protein Hox-A2	376	41002	5.54	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	Microtia, hearing impairment, and cleft palate;Microtia with or without hearing impairment	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family. Proboscipedia subfamily.	Activation of anterior HOX genes in hindbrain development during early embryogenesis;Regulation of expression of SLITs and ROBOs	PE1	7
+NX_O43365	Homeobox protein Hox-A3	443	46369	9.3	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	7
+NX_O43374	Ras GTPase-activating protein 4	803	90458	8.01	0	Cytosol;Cell membrane	NA	Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.	NA	NA	Regulation of RAS by GAPs;Signaling by RAS mutants	PE1	7
+NX_O43379	WD repeat-containing protein 62	1518	165954	5.57	0	Centriole;Centriolar satellite;Spindle pole;Centrosome;Cytosol;Nucleus	Microcephaly 2, primary, autosomal recessive, with or without cortical malformations	Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806).	NA	NA	NA	PE1	19
+NX_O43390	Heterogeneous nuclear ribonucleoprotein R	633	70943	8.23	0	Nucleoplasm;Nucleus;Cytoplasm;Microsome	NA	Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). HnRNP play an important role in processing of precursor mRNA in the nucleus.	NA	NA	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA	PE1	1
+NX_O43395	U4/U6 small nuclear ribonucleoprotein Prp3	683	77529	9.5	0	Nucleoplasm;Nucleus speckle;Nucleus	Retinitis pigmentosa 18	Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).	Ubiquitinated. Undergoes 'Lys-63'-linked polyubiquitination by PRPF19 and deubiquitination by USP4. 'Lys-63'-linked ubiquitination increases the affinity for PRPF8 and may regulate the assembly of the U4/U6-U5 tri-snRNP complex.	NA	Spliceosome;mRNA Splicing - Major Pathway	PE1	1
+NX_O43396	Thioredoxin-like protein 1	289	32251	4.84	0	Cytoplasm;Cytosol;Nucleus	NA	Active thioredoxin with a redox potential of about -250 mV.	NA	NA	NA	PE1	18
+NX_O43399	Tumor protein D54	206	22238	5.26	0	Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the TPD52 family.	NA	PE1	20
+NX_O43402	ER membrane protein complex subunit 8	210	23773	5.92	0	Cytoplasm;Cytosol;Mitochondrion	NA	NA	NA	Belongs to the EMC8/EMC9 family.	NA	PE1	16
+NX_O43405	Cochlin	550	59483	8.17	0	Cytoplasmic vesicle;Extracellular matrix	Deafness, autosomal dominant, 9;Deafness, autosomal recessive, 110	Plays a role in the control of cell shape and motility in the trabecular meshwork.	N-glycosylated.;A 50 kDa form is created by proteolytic cleavage.	NA	NA	PE1	14
+NX_O43414	ERI1 exoribonuclease 3	337	37238	8.33	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_O43422	52 kDa repressor of the inhibitor of the protein kinase	761	87704	5.58	0	Nucleoplasm	NA	Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.	NA	NA	NA	PE1	11
+NX_O43423	Acidic leucine-rich nuclear phosphoprotein 32 family member C	234	26762	4.14	0	NA	NA	NA	NA	Belongs to the ANP32 family.	NA	PE1	4
+NX_O43424	Glutamate receptor ionotropic, delta-2	1007	113356	5.73	3	Cell membrane;Postsynaptic cell membrane	Spinocerebellar ataxia, autosomal recessive, 18	Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511).	NA	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily.	Neuroactive ligand-receptor interaction;Long-term depression	PE1	4
+NX_O43426	Synaptojanin-1	1573	173103	7.13	0	Nucleoplasm;Cytosol;Perinuclear region;Centrosome	Parkinson disease 20, early-onset;Epileptic encephalopathy, early infantile, 53	Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity).	SYNJ1 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.;Belongs to the synaptojanin family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the plasma membrane;Synthesis of IP2, IP, and Ins in the cytosol;Synthesis of IP3 and IP4 in the cytosol;Clathrin-mediated endocytosis	PE1	21
+NX_O43427	Acidic fibroblast growth factor intracellular-binding protein	364	41878	6.02	0	Endomembrane system;Nucleus speckle;Nucleus	Thauvin-Robinet-Faivre syndrome	May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).	NA	NA	NA	PE1	11
+NX_O43432	Eukaryotic translation initiation factor 4 gamma 3	1585	176652	5.27	0	Cytoplasm;Cytosol	NA	Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.	Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.;EIF4G3 is phosphorylated by MAPK3	Belongs to the eukaryotic initiation factor 4G family.	RNA transport;Viral myocarditis;ISG15 antiviral mechanism	PE1	1
+NX_O43435	T-box transcription factor TBX1	398	43133	8.37	0	Cytosol;Nucleus	Conotruncal heart malformations;Velocardiofacial syndrome;DiGeorge syndrome	Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity).	NA	NA	NA	PE1	22
+NX_O43439	Protein CBFA2T2	604	67133	8.32	0	Nucleus speckle;Nucleus	NA	Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity).	NA	Belongs to the CBFA2T family.	NA	PE1	20
+NX_O43447	Peptidyl-prolyl cis-trans isomerase H	177	19208	8.28	0	Cytoplasm;Nucleus speckle	NA	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.	NA	Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.	Spliceosome;mRNA Splicing - Major Pathway	PE1	1
+NX_O43448	Voltage-gated potassium channel subunit beta-3	404	43670	8.87	0	Cytoplasm;Mitochondrion	NA	Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.	NA	Belongs to the shaker potassium channel beta subunit family.	Voltage gated Potassium channels	PE1	17
+NX_O43451	Maltase-glucoamylase, intestinal	1857	209852	5.27	1	Apical cell membrane	NA	May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.	N- and O-glycosylated.;Does not undergo intracellular or extracellular proteolytic cleavage.;Sulfated.	Belongs to the glycosyl hydrolase 31 family.	Galactose metabolism;Starch and sucrose metabolism;Metabolic pathways;Carbohydrate digestion and absorption;Digestion of dietary carbohydrate;Neutrophil degranulation	PE1	7
+NX_O43462	Membrane-bound transcription factor site-2 protease	519	57444	7.21	10	Cytoplasm;Mitochondrion;Membrane;Nucleoplasm;Cytosol	Osteogenesis imperfecta 19;Keratosis follicularis spinulosa decalvans X-linked;IFAP syndrome with or without BRESHECK syndrome;Olmsted syndrome, X-linked	Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription (PubMed:9659902, PubMed:27380894). Involved in RIP-mediated regulation of bone formation (PubMed:27380894).	NA	Belongs to the peptidase M50A family.	Protein processing in endoplasmic reticulum;Regulation of cholesterol biosynthesis by SREBP (SREBF);ATF6 (ATF6-alpha) activates chaperones;CREB3 factors activate genes;Assembly of active LPL and LIPC lipase complexes	PE1	X
+NX_O43463	Histone-lysine N-methyltransferase SUV39H1	412	47907	8.38	0	Nucleoplasm;Nucleus lamina;Centromere;Nucleus	NA	Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.	Acetylated at Lys-266, leading to inhibition of enzyme activity. SIRT1-mediated deacetylation relieves this inhibition.;Phosphorylated on serine residues, and to a lesser degree, on threonine residues. The phosphorylated form is stabilized by SBF1 and is less active in its transcriptional repressor function.	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	Lysine degradation;PKMTs methylate histone lysines;SIRT1 negatively regulates rRNA expression	PE1	X
+NX_O43464	Serine protease HTRA2, mitochondrial	458	48841	10.07	1	Mitochondrion membrane;Mitochondrion intermembrane space;Mitochondrion	Parkinson disease 13;3-methylglutaconic aciduria 8	Seems to be proteolytically inactive.;Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis.	Autoproteolytically activated.	Belongs to the peptidase S1C family.	Parkinson's disease	PE1	2
+NX_O43474	Krueppel-like factor 4	513	54671	8.69	0	Nucleoplasm;Nucleus	NA	Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Transcriptional regulation of pluripotent stem cells;Transcriptional regulation of white adipocyte differentiation;Synthesis, secretion, and deacylation of Ghrelin;FOXO-mediated transcription of cell cycle genes	PE1	9
+NX_O43482	Protein Mis18-beta	229	24691	7.02	0	Nucleus speckle;Chromosome;Centromere;Cytoplasmic vesicle;Nucleus	NA	Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.	NA	Belongs to the mis18 family.	Deposition of new CENPA-containing nucleosomes at the centromere	PE1	15
+NX_O43488	Aflatoxin B1 aldehyde reductase member 2	359	39589	6.7	0	Golgi apparatus;Cytoplasm	NA	Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.	NA	Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.	Metabolism of xenobiotics by cytochrome P450;Aflatoxin activation and detoxification	PE1	1
+NX_O43490	Prominin-1	865	97202	6.97	5	Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment;Cell membrane;Photoreceptor outer segment;Microvillus membrane;Endoplasmic reticulum;Apical cell membrane	Retinitis pigmentosa 41;Retinal macular dystrophy 2;Cone-rod dystrophy 12;Stargardt disease 4	May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).	Are glycosylated.;Acetylation at Lys-225, Lys-257 and Lys-264 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis.	Belongs to the prominin family.	NA	PE1	4
+NX_O43491	Band 4.1-like protein 2	1005	112588	5.34	0	Cell cortex;Cell membrane;Cell junction;Nucleoplasm;Cytoskeleton	NA	Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).	NA	NA	Tight junction;Neurexins and neuroligins	PE1	6
+NX_O43493	Trans-Golgi network integral membrane protein 2	437	45880	5.46	1	Golgi apparatus;Nucleoplasm;trans-Golgi network membrane;Cell membrane	NA	May be involved in regulating membrane traffic to and from trans-Golgi network.	NA	NA	Golgi Associated Vesicle Biogenesis;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation	PE1	2
+NX_O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	2377	262472	6.14	24	Cytoplasm;Cell membrane	Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits;Spinocerebellar ataxia 42	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.	In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily.	MAPK signaling pathway;Calcium signaling pathway;Type II diabetes mellitus;NCAM1 interactions	PE1	17
+NX_O43502	DNA repair protein RAD51 homolog 3	376	42190	6.28	0	Cytoplasm;Mitochondrion;Cell junction;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Perinuclear region;Nucleus	Breast-ovarian cancer, familial, 3;Fanconi anemia complementation group O	Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.	NA	Belongs to the RecA family. RAD51 subfamily.	Homologous recombination;Fanconi anemia pathway;Factors involved in megakaryocyte development and platelet production;Meiotic recombination;HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Presynaptic phase of homologous DNA pairing and strand exchange	PE1	17
+NX_O43504	Ragulator complex protein LAMTOR5	91	9614	4.69	0	Cytoplasm;Lysosome	NA	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.	NA	Belongs to the LAMTOR5 family.	Macroautophagy;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;mTOR signalling;mTORC1-mediated signalling;Regulation of PTEN gene transcription	PE1	1
+NX_O43505	Beta-1,4-glucuronyltransferase 1	415	47119	6.77	1	Golgi apparatus membrane	Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A13	Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity).	NA	Belongs to the glycosyltransferase 49 family.	Protein modification; protein glycosylation.;Glycosaminoglycan biosynthesis - keratan sulfate;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Keratan sulfate biosynthesis;O-linked glycosylation;Defective LARGE causes MDDGA6 and MDDGB6	PE1	11
+NX_O43506	Disintegrin and metalloproteinase domain-containing protein 20	726	81603	6.02	1	Membrane	NA	May be involved in sperm maturation and/or fertilization.	Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated.	NA	Interaction With Cumulus Cells And The Zona Pellucida	PE2	14
+NX_O43508	Tumor necrosis factor ligand superfamily member 12	249	27216	9.5	1	Cytoplasmic vesicle;Secreted;Cell membrane	NA	Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.	The soluble form derives from the membrane form by proteolytic processing.	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	PE1	17
+NX_O43511	Pendrin	780	85723	6.04	12	Membrane;Cell membrane	Deafness, autosomal recessive, 4;Pendred syndrome	Sodium-independent transporter of chloride and iodide.	NA	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Multifunctional anion exchangers;Defective SLC26A4 causes Pendred syndrome (PDS)	PE1	7
+NX_O43513	Mediator of RNA polymerase II transcription subunit 7	233	27245	5.5	0	Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Constitutively sumoylated.	Belongs to the Mediator complex subunit 7 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	5
+NX_O43516	WAS/WASL-interacting protein family member 1	503	51258	11.47	0	Cell membrane;Ruffle;Cytoplasmic vesicle;Cytosol;Cytoskeleton	Wiskott-Aldrich syndrome 2	Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.	NA	Belongs to the verprolin family.	Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs	PE1	2
+NX_O43520	Phospholipid-transporting ATPase IC	1251	143695	6.77	10	Golgi apparatus;Cell membrane;Apical cell membrane;Nucleoplasm;Endoplasmic reticulum;Stereocilium;Cytosol;Nucleus	Cholestasis, progressive familial intrahepatic, 1;Cholestasis, benign recurrent intrahepatic, 1;Cholestasis of pregnancy, intrahepatic 1	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both. In cooperation with ABCB4 may be involved in establishing integrity of the canalicular membrane thus protecting hepatocytes from bile salts. Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Required for the preservation of cochlear hair cells in the inner ear. May act as cardiolipin transporter during inflammatory injury.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases	PE1	18
+NX_O43521	Bcl-2-like protein 11	198	22171	8.43	0	Endomembrane system;Mitochondrion	NA	Is more potent than isoform BimEL.;Induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS.;Induces apoptosis and anoikis.;Lack the ability to induce apoptosis.;Induces apoptosis.;Induces apoptosis possibly through a caspase-mediated pathway.	Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation (PubMed:15486195, PubMed:21478148). Deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).;Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation. Conversely, deubiquitination catalyzed by USP27X stabilizes the protein.	Belongs to the Bcl-2 family.	NRAGE signals death through JNK;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Activation of BIM and translocation to mitochondria;Signaling by BRAF and RAF fusions;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;RUNX3 regulates BCL2L11 (BIM) transcription;FOXO-mediated transcription of cell death genes	PE1	2
+NX_O43524	Forkhead box protein O3	673	71277	4.98	0	Mitochondrion outer membrane;Mitochondrion matrix;Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301).	Polyubiquitinated. Ubiquitinated by a SCF complex containing SKP2, leading to proteasomal degradation.;The N-terminus is cleaved following import into the mitochondrion.;Heavily methylated by SET9 which decreases stability, while moderately increasing transcriptional activity. The main methylation site is Lys-271. Methylation doesn't affect subcellular location.;In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB (PubMed:10102273). This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm (PubMed:10102273). Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis (PubMed:10102273). Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue (PubMed:10102273, PubMed:11154281). Phosphorylated by STK4/MST1 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation (PubMed:16751106). Phosphorylated by PIM1 (PubMed:18593906). Phosphorylation by AMPK leads to the activation of transcriptional activity without affecting subcellular localization (PubMed:17711846). In response to metabolic stress, phosphorylated by AMPK on Ser-30 which mediates FOXO3 mitochondrial translocation (PubMed:29445193). Phosphorylation by MAPKAPK5 promotes nuclear localization and DNA-binding, leading to induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). Phosphorylated by CHUK/IKKA and IKBKB/IKKB (PubMed:15084260). TNF-induced inactivation of FOXO3 requires its phosphorylation at Ser-644 by IKBKB/IKKB which promotes FOXO3 retention in the cytoplasm, polyubiquitination and ubiquitin-mediated proteasomal degradation (PubMed:15084260). May be dephosphorylated by calcineurin A on Ser-299 which abolishes FOXO3 transcriptional activity (By similarity). In cancer cells, ERK mediated-phosphorylation of Ser-12 is required for mitochondrial translocation of FOXO3 in response to metabolic stress or chemotherapeutic agents (PubMed:29445193).;Deacetylation by SIRT1 or SIRT2 stimulates interaction of FOXO3 with SKP2 and facilitates SCF(SKP2)-mediated FOXO3 ubiquitination and proteasomal degradation (PubMed:21841822). Deacetylation by SIRT2 stimulates FOXO3-mediated transcriptional activity in response to oxidative stress (By similarity). Deacetylated by SIRT3 (PubMed:23283301). Deacetylation by SIRT3 stimulates FOXO3-mediated mtDNA transcriptional activity in response to metabolic stress (PubMed:23283301).	NA	Chemokine signaling pathway;Neurotrophin signaling pathway;Endometrial cancer;Non-small cell lung cancer;MAPK6/MAPK4 signaling;AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;Signaling by NODAL;Interleukin-4 and Interleukin-13 signaling;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;RUNX3 regulates BCL2L11 (BIM) transcription;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell death genes;Estrogen-dependent nuclear events downstream of ESR-membrane signaling;Regulation of localization of FOXO transcription factors;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes	PE1	6
+NX_O43525	Potassium voltage-gated channel subfamily KQT member 3	872	96742	8.98	6	Cell membrane	Seizures, benign familial neonatal 2	Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.	KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation (Probable). Degradation induced by NEDD4L is inhibited by USP36 (PubMed:27445338).	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.	Cholinergic synapse;Voltage gated Potassium channels;Interaction between L1 and Ankyrins	PE1	8
+NX_O43526	Potassium voltage-gated channel subfamily KQT member 2	872	95848	9.35	6	Endoplasmic reticulum;Cell membrane	Seizures, benign familial neonatal 1;Epileptic encephalopathy, early infantile, 7	Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873).	KCNQ2/KCNQ3 heteromeric current can be increased by intracellular cyclic AMP, an effect that depends on phosphorylation of Ser-52 in the N-terminal region.;KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation (Probable). Degradation induced by NEDD4L is inhibited by USP36 (PubMed:27445338).	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily.	Cholinergic synapse;Voltage gated Potassium channels;Interaction between L1 and Ankyrins	PE1	20
+NX_O43529	Carbohydrate sulfotransferase 10	356	42207	8.11	1	Cytosol;Golgi apparatus membrane	NA	Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis.	NA	Belongs to the sulfotransferase 2 family.	Other types of O-glycan biosynthesis;Reactions specific to the complex N-glycan synthesis pathway	PE1	2
+NX_O43541	Mothers against decapentaplegic homolog 6	496	53497	8.46	0	Golgi apparatus;Nucleoplasm;Nucleus	Craniosynostosis 7;Aortic valve disease 2	Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.	Phosphorylated by BMP type 1 receptor kinase and by PRKX.;Arginine methylation by PRMT1, which is recruited by BMPR2, initiates BMP-Induced signaling and induces dissociation from the BMPR1B receptor at the cell surface leading to derepress downstream Smad1/Smad5 signaling.;Monoubiquitinated at Lys-173 by the E2/E3 hybrid ubiquitin-protein ligase UBE2O, leading to reduced binding affinity for the activated BMP type I receptor ACVR1/ALK2, thereby enhancing BMP7 and regulating adipocyte differentiation (PubMed:23455153). Ubiquitinated by WWP1 (By similarity). Ubiquitinated by RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling (By similarity).	Belongs to the dwarfin/SMAD family.	Endocytosis;TGF-beta signaling pathway;Signaling by BMP;RUNX2 regulates bone development	PE1	15
+NX_O43542	DNA repair protein XRCC3	346	37850	8.81	0	Cytoplasm;Mitochondrion;Nucleoplasm;Perinuclear region;Nucleus	Breast cancer;Melanoma, cutaneous malignant 6	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.	NA	Belongs to the RecA family. RAD51 subfamily.	Homologous recombination;HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange	PE1	14
+NX_O43543	DNA repair protein XRCC2	280	31956	5.67	0	Nucleoplasm;Centrosome;Nucleus;Cytoplasmic vesicle	Fanconi anemia, complementation group U	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.	NA	Belongs to the RecA family. RAD51 subfamily.	Homologous recombination;HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Presynaptic phase of homologous DNA pairing and strand exchange	PE1	7
+NX_O43548	Protein-glutamine gamma-glutamyltransferase 5	720	80778	6.01	0	Cytoplasm	Peeling skin syndrome 2	Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.	NA	Belongs to the transglutaminase superfamily. Transglutaminase family.	Formation of the cornified envelope	PE1	15
+NX_O43555	Progonadoliberin-2	120	12918	11.12	0	Secreted	NA	Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.	NA	Belongs to the GnRH family.	GnRH signaling pathway;G alpha (q) signalling events;Hormone ligand-binding receptors	PE2	20
+NX_O43556	Epsilon-sarcoglycan	437	49851	6.12	1	Golgi apparatus;Cell membrane;Nucleoplasm;Sarcolemma;Cytoplasmic vesicle;Dendrite;Cytoskeleton	Dystonia 11, myoclonic	Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.	Ubiquitinated, leading to its degradation by the proteasome.;N-glycosylated.	Belongs to the sarcoglycan alpha/epsilon family.	NA	PE1	7
+NX_O43557	Tumor necrosis factor ligand superfamily member 14	240	26350	9.09	1	Cytoplasm;Secreted;Cell membrane	NA	Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:9462508, PubMed:10754304). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304).	N-glycosylated.;The soluble form of isoform 1 derives from the membrane form by proteolytic processing.	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;Herpes simplex infection;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;TNFs bind their physiological receptors	PE1	19
+NX_O43559	Fibroblast growth factor receptor substrate 3	492	54462	6.81	0	Membrane;Nucleoplasm	NA	Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.	Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.;FRS3 is phosphorylated by ULK2	NA	RAF/MAP kinase cascade;FRS-mediated FGFR1 signaling;FRS-mediated FGFR2 signaling;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;Activated NTRK2 signals through FRS2 and FRS3	PE1	6
+NX_O43561	Linker for activation of T-cells family member 1	262	27930	4.27	1	Golgi apparatus;Cell membrane	Immunodeficiency 52	Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.	Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.;Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes.;LAT is phosphorylated by ABL1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;RAF/MAP kinase cascade;Generation of second messenger molecules;GPVI-mediated activation cascade;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Fc epsilon receptor (FCERI) signaling	PE1	16
+NX_O43566	Regulator of G-protein signaling 14	566	61447	8.46	0	Cytoplasm;Dendritic spine;Cell membrane;Membrane;Nucleoplasm;Spindle pole;Centrosome;Postsynaptic density;PML body;Cytoplasmic vesicle;Spindle;Dendrite;Nucleus;Cytoskeleton	NA	Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.	Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i) alpha subunit GNAI1 (By similarity).	NA	G alpha (i) signalling events	PE1	5
+NX_O43567	E3 ubiquitin-protein ligase RNF13	381	42814	4.83	1	Endoplasmic reticulum membrane;Lysosome membrane;Nucleoplasm;Nucleus inner membrane;Golgi apparatus membrane;Cytoplasmic vesicle;Cytosol;Late endosome membrane	Epileptic encephalopathy, early infantile, 73	E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371).	Auto-ubiquitinated.	NA	Protein modification; protein ubiquitination.	PE1	3
+NX_O43570	Carbonic anhydrase 12	354	39451	6.73	1	Membrane;Nucleoplasm;Cell membrane;Cytoplasmic vesicle	Hyperchlorhidrosis, isolated	Reversible hydration of carbon dioxide.	NA	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Reversible hydration of carbon dioxide	PE1	15
+NX_O43572	A-kinase anchor protein 10, mitochondrial	662	73818	5.96	0	Cytoplasm;Mitochondrion;Cell membrane;Membrane;Cytosol	Sudden cardiac death	Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).	NA	NA	Factors involved in megakaryocyte development and platelet production	PE1	17
+NX_O43581	Synaptotagmin-7	403	45501	9.29	1	Presynaptic cell membrane;Cell membrane;Phagosome membrane;Peroxisome membrane;Lysosome membrane;Synaptic vesicle membrane;Secretory vesicle membrane	NA	Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity).	Palmitoylated at its vesicular N-terminus; palmitoylation is required for localization to lysosome and phagocytosis in macrophages.	Belongs to the synaptotagmin family.	Neurexins and neuroligins	PE1	11
+NX_O43583	Density-regulated protein	198	22092	5.21	0	Cytosol	NA	May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.	NA	Belongs to the DENR family.	NA	PE1	12
+NX_O43586	Proline-serine-threonine phosphatase-interacting protein 1	416	47591	5.35	0	Cytoplasm;Cleavage furrow;Cell membrane;Lamellipodium;Uropodium;Perinuclear region;Cytoskeleton	PAPA syndrome	Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.	Dephosphorylated on Tyr-345 by PTPN18, this event negatively regulates the association of PSTPIP1 with SH2 domain-containing proteins as tyrosine kinase. Phosphorylation of Tyr-345 is probably required for subsequent phosphorylation at other tyrosine residues. Phosphorylation is induced by activation of the EGFR and PDGFR in a ABL1 dependent manner. The phosphorylation regulates the interaction with WAS and with MEFV (By similarity).	NA	NOD-like receptor signaling pathway;The NLRP3 inflammasome	PE1	15
+NX_O43592	Exportin-T	962	109964	5.24	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.	NA	Belongs to the exportin family.	RNA transport;tRNA processing in the nucleus	PE1	12
+NX_O43593	Lysine-specific demethylase hairless	1189	127495	6.67	0	Nucleoplasm;Nucleus	Alopecia universalis congenita;Hypotrichosis 4;Atrichia with papular lesions	Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle.	NA	NA	NA	PE1	8
+NX_O43597	Protein sprouty homolog 2	315	34688	8.78	0	Ruffle membrane;Endosome;Cytoskeleton	IgA nephropathy 3	May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.	Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).	Belongs to the sprouty family.	Jak-STAT signaling pathway;EGFR downregulation;Spry regulation of FGF signaling	PE1	13
+NX_O43598	2'-deoxynucleoside 5'-phosphate N-hydrolase 1	174	19108	4.97	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.	NA	Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.	Purine catabolism	PE1	6
+NX_O43602	Neuronal migration protein doublecortin	365	40574	9.33	0	Neuron projection;Cytoplasm;Cytosol	Subcortical band heterotopia X-linked;Lissencephaly, X-linked 1	Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.	Ubiquitinated by MDM2, leading to its degradation by the proteasome. Ubiquitinated by MDM2 and subsequent degradation leads to reduce the dendritic spine density of olfactory bulb granule cells.;Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules (By similarity). Phosphorylation at Ser-265 and Ser-297 seems to occur only in neonatal brain, the levels falling precipitously by postnatal day 21 (By similarity).	NA	Neurofascin interactions	PE1	X
+NX_O43603	Galanin receptor type 2	387	41700	9.6	7	Cell membrane	NA	Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	17
+NX_O43609	Protein sprouty homolog 1	319	35122	8.65	0	Cytoplasm;Golgi apparatus;Membrane;Nucleoplasm;Cytosol	NA	May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.	NA	Belongs to the sprouty family.	Jak-STAT signaling pathway;EGFR downregulation	PE1	4
+NX_O43610	Protein sprouty homolog 3	288	31222	7.4	0	Membrane;Cytoplasm;Cytosol;Nucleolus	NA	May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.	NA	Belongs to the sprouty family.	Jak-STAT signaling pathway	PE1	X
+NX_O43612	Orexin	131	13363	10.8	0	Cytoplasmic vesicle;Synapse;Rough endoplasmic reticulum	Narcolepsy 1	Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.	Specific enzymatic cleavages at paired basic residues yield the different active peptides.	Belongs to the orexin family.	G alpha (q) signalling events;Orexin and neuropeptides FF and QRFP bind to their respective receptors	PE1	17
+NX_O43613	Orexin receptor type 1	425	47536	9.3	7	Cell membrane	NA	Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Orexin and neuropeptides FF and QRFP bind to their respective receptors	PE1	1
+NX_O43614	Orexin receptor type 2	444	50694	8.99	7	Cell membrane	NA	Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Orexin and neuropeptides FF and QRFP bind to their respective receptors	PE1	6
+NX_O43615	Mitochondrial import inner membrane translocase subunit TIM44	452	51356	8.51	0	Mitochondrion matrix;Mitochondrion inner membrane;Mitochondrion	NA	Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.	NA	Belongs to the Tim44 family.	Mitochondrial protein import	PE1	19
+NX_O43617	Trafficking protein particle complex subunit 3	180	20274	4.88	0	Endoplasmic reticulum;Golgi apparatus;Cytosol;cis-Golgi network	NA	May play a role in vesicular transport from endoplasmic reticulum to Golgi.	NA	Belongs to the TRAPP small subunits family. BET3 subfamily.	COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs	PE1	1
+NX_O43623	Zinc finger protein SNAI2	268	29986	9.01	0	Nucleoplasm;Cytoplasm;Nucleus	Waardenburg syndrome 2D;Piebald trait	Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.	GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.	Belongs to the snail C2H2-type zinc-finger protein family.	Regulation of PTEN gene transcription	PE1	8
+NX_O43633	Charged multivesicular body protein 2a	222	25104	5.87	0	Nucleoplasm;Cytosol;Late endosome membrane;Cell membrane	NA	(Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release.;Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.	ISGylated in a CHMP5-dependent manner. Isgylation weakens and inhibits its interactions with VPS4A and VTA1 respectively.	Belongs to the SNF7 family.	Endocytosis;Macroautophagy;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT);Lysosome Vesicle Biogenesis;Microautophagy	PE1	19
+NX_O43638	Forkhead box protein S1	330	35434	9.28	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).	NA	NA	NA	PE1	20
+NX_O43639	Cytoplasmic protein NCK2	380	42915	6.49	0	Endoplasmic reticulum;Cytoplasm	NA	Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.	Phosphorylated.	NA	ErbB signaling pathway;Axon guidance;T cell receptor signaling pathway;Pathogenic Escherichia coli infection;Ephrin signaling;VEGFA-VEGFR2 Pathway;Nephrin family interactions;Activation of RAC1;Downstream signal transduction;Regulation of cortical dendrite branching	PE1	2
+NX_O43653	Prostate stem cell antigen	114	11959	4.75	0	Cell membrane	NA	May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.;May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.	N-glycosylated.	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	8
+NX_O43657	Tetraspanin-6	245	27563	8.44	4	Membrane;Cytosol;Cell junction;Nucleolus	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	X
+NX_O43660	Pleiotropic regulator 1	514	57194	9.24	0	Nucleus speckle;Nucleus membrane;Nucleus	NA	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257).	NA	Belongs to the WD repeat PRL1/PRL2 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	4
+NX_O43663	Protein regulator of cytokinesis 1	620	71607	6.29	0	Cytoplasm;Cell membrane;Nucleoplasm;Spindle pole;Nucleus;Midbody;Cytoskeleton	NA	Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).	Phosphorylation by CDK1 in early mitosis holds PRC1 in an inactive monomeric state, during the metaphase to anaphase transition, PRC1 is dephosphorylated, promoting interaction with KIF4A, which then translocates PRC1 along mitotic spindles to the plus ends of antiparallel interdigitating microtubules. Dephosphorylation also promotes MT-bundling activity by allowing dimerization. Phosphorylation by CDK1 prevents PLK1-binding: upon degradation of CDK1 at anaphase and dephosphorylation, it is then phosphorylated by PLK1, leading to cytokinesis.	Belongs to the MAP65/ASE1 family.	RHO GTPases activate CIT	PE1	15
+NX_O43665	Regulator of G-protein signaling 10	181	21210	6.93	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).	NA	NA	G alpha (i) signalling events	PE1	10
+NX_O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	478	50751	9.19	0	Kinetochore;Nucleoplasm;Spindle;Nucleus	NA	Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).	NA	NA	NA	PE1	17
+NX_O43674	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	189	21750	9.62	1	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFB5 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	3
+NX_O43676	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	98	11402	9.19	1	Mitochondrion inner membrane	Mitochondrial complex I deficiency, nuclear type 25	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFB3 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	2
+NX_O43677	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	76	8734	10.2	1	Mitochondrion inner membrane;Mitochondrion;Cell membrane	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFC1 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	4
+NX_O43678	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	99	10922	9.62	0	Mitochondrion inner membrane	Mitochondrial complex I deficiency, nuclear type 13	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFA2 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	5
+NX_O43679	LIM domain-binding protein 2	373	42793	6.47	0	Nucleoplasm;Nucleus;Nucleolus;Cell membrane	NA	Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.	Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome.	Belongs to the LDB family.	NA	PE1	4
+NX_O43680	Transcription factor 21	179	19715	9.15	0	Nucleus	NA	Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.	NA	NA	NA	PE2	6
+NX_O43681	ATPase ASNA1	348	38793	4.81	0	Endoplasmic reticulum;Nucleoplasm;Cytoplasm;Nucleolus	NA	ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.	NA	Belongs to the arsA ATPase family.	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	19
+NX_O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	1085	122375	6.03	0	Kinetochore;Nucleoplasm;Cytosol;Nucleus	NA	Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.	Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1.;Upon spindle-assembly checkpoint activation it is hyperphosphorylated and its kinase activity toward CDC20 is stimulated. Phosphorylation at Thr-609 is required for interaction with PLK1, phosphorylation at this site probably creates a binding site for the POLO-box domain of PLK1, thus enhancing the PLK1-BUB1 interaction.;BUB1 is phosphorylated by PLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.	Cell cycle;Oocyte meiosis;Progesterone-mediated oocyte maturation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	2
+NX_O43684	Mitotic checkpoint protein BUB3	328	37155	6.36	0	Kinetochore;Nucleoplasm;Nucleus	NA	Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.	Poly-ADP-ribosylated by PARP1.	Belongs to the WD repeat BUB3 family.	Cell cycle;HTLV-I infection;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of mitotic proteins;APC-Cdc20 mediated degradation of Nek2A;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	10
+NX_O43687	A-kinase anchor protein 7 isoforms alpha and beta	104	11465	4.89	0	Apical cell membrane;Lateral cell membrane	NA	Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.	NA	NA	NA	PE1	6
+NX_O43688	Phospholipid phosphatase 2	288	32574	8.65	6	Membrane;Mitochondrion	NA	Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.	NA	Belongs to the PA-phosphatase related phosphoesterase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Ether lipid metabolism;Sphingolipid metabolism;Metabolic pathways;Fc gamma R-mediated phagocytosis;Fat digestion and absorption;Sphingolipid de novo biosynthesis	PE1	19
+NX_O43692	Peptidase inhibitor 15	258	29065	8.37	0	Cytoplasmic vesicle;Cytosol;Secreted	NA	Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity).	N-glycosylated.	Belongs to the CRISP family.	NA	PE1	8
+NX_O43699	Sialic acid-binding Ig-like lectin 6	453	49913	6.7	1	Secreted;Cell membrane	NA	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.	NA	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_O43704	Sulfotransferase family cytosolic 1B member 1	296	34899	6.57	0	Golgi apparatus;Cytoplasm;Nucleoplasm	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.	NA	Belongs to the sulfotransferase 1 family.	Cytosolic sulfonation of small molecules	PE1	4
+NX_O43707	Alpha-actinin-4	911	104854	5.27	0	Cytoplasm;Stress fiber;Cell junction;Nucleus	Focal segmental glomerulosclerosis 1	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778).	NA	Belongs to the alpha-actinin family.	Focal adhesion;Adherens junction;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Amoebiasis;Systemic lupus erythematosus;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Platelet degranulation;Nephrin family interactions	PE1	19
+NX_O43708	Maleylacetoacetate isomerase	216	24212	8.8	0	Nucleoplasm;Cytosol;Cytoplasm	Maleylacetoacetate isomerase deficiency	Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.	NA	Belongs to the GST superfamily. Zeta family.	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.;Tyrosine metabolism;Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Glutathione conjugation;Regulation of pyruvate dehydrogenase (PDH) complex;Tyrosine catabolism	PE1	14
+NX_O43709	Probable 18S rRNA (guanine-N(7))-methyltransferase	281	31880	8.95	0	Cytoplasm;Nucleolus;Nucleoplasm;Perinuclear region;Nucleus	NA	S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492).	May be ubiquitinated and targeted to degradation in response to proinflammatory cytokine signaling.	Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.	Histidine metabolism;Tyrosine metabolism;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	7
+NX_O43711	T-cell leukemia homeobox protein 3	291	31867	9.95	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	5
+NX_O43715	TP53-regulated inhibitor of apoptosis 1	76	8786	5.37	0	Nucleoplasm;Mitochondrion intermembrane space;Mitochondrion;Perinuclear region	NA	Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).	NA	Belongs to the TRIAP1/MDM35 family.	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	PE1	12
+NX_O43716	Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial	136	15086	4.94	0	Mitochondrion	NA	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).	NA	Belongs to the GatC family.	NA	PE1	12
+NX_O43719	HIV Tat-specific factor 1	755	85853	4.29	0	Nucleoplasm;Nucleus	NA	Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.	NA	Belongs to the HTATSF1 family.	NA	PE1	X
+NX_O43731	ER lumen protein-retaining receptor 3	214	25027	9.07	7	Endoplasmic reticulum;COPI-coated vesicle membrane;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.	NA	Belongs to the ERD2 family.	Vibrio cholerae infection;XBP1(S) activates chaperone genes;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	22
+NX_O43734	Adapter protein CIKS	574	64666	6.27	0	Golgi apparatus;Cytoplasmic vesicle	Psoriasis 13;Candidiasis, familial, 8	Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.	NA	NA	NA	PE1	6
+NX_O43736	Integral membrane protein 2A	263	29741	5.65	1	Golgi apparatus;Cytoplasmic vesicle;Membrane;Cell membrane	NA	NA	NA	Belongs to the ITM2 family.	NA	PE1	X
+NX_O43739	Cytohesin-3	400	46349	5.35	0	Cell membrane;Adherens junction;Nucleoplasm;Tight junction;Cytosol	NA	Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Play a role in the epithelial polarization (By similarity).	NA	NA	Intra-Golgi traffic	PE1	7
+NX_O43741	5'-AMP-activated protein kinase subunit beta-2	272	30302	5.99	0	Nucleoplasm	NA	Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).	Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.;PRKAB2 is phosphorylated by ULK2	Belongs to the 5'-AMP-activated protein kinase beta subunit family.	Insulin signaling pathway;Adipocytokine signaling pathway;Hypertrophic cardiomyopathy (HCM);Macroautophagy;Translocation of SLC2A4 (GLUT4) to the plasma membrane;TP53 Regulates Metabolic Genes;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Energy dependent regulation of mTOR by LKB1-AMPK;AMPK inhibits chREBP transcriptional activation activity;Import of palmitoyl-CoA into the mitochondrial matrix;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs;Lipophagy	PE1	1
+NX_O43745	Calcineurin B homologous protein 2	196	22452	5.89	0	Cytoplasm;Nucleus;Cell membrane	NA	Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.	NA	Belongs to the calcineurin regulatory subunit family. CHP subfamily.	MAPK signaling pathway;Calcium signaling pathway;Oocyte meiosis;Apoptosis;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Long-term potentiation;Glutamatergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Tuberculosis	PE1	16
+NX_O43747	AP-1 complex subunit gamma-1	822	91351	6.36	0	Cytoplasmic vesicle;Golgi apparatus;Cytosol;Clathrin-coated vesicle membrane	NA	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	NA	Belongs to the adaptor complexes large subunit family.	Lysosome;MHC class II antigen presentation;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Nef mediated downregulation of MHC class I complex cell surface expression	PE1	16
+NX_O43749	Olfactory receptor 1F1	312	34866	7.59	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	16
+NX_O43752	Syntaxin-6	255	29176	4.84	1	Golgi apparatus;Nucleoplasm;Golgi apparatus membrane	NA	Involved in intracellular vesicle trafficking.	NA	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network	PE1	1
+NX_O43759	Synaptogyrin-1	233	25456	4.5	4	Cytosol;Synaptic vesicle membrane;Melanosome	NA	May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).	NA	Belongs to the synaptogyrin family.	Neutrophil degranulation	PE1	22
+NX_O43760	Synaptogyrin-2	224	24810	4.75	4	Cytoplasmic vesicle membrane;Synaptic vesicle membrane;Lipid droplet	NA	(Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication.;May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane.	May be tyrosine phosphorylated by Src.	Belongs to the synaptogyrin family.	NA	PE1	17
+NX_O43761	Synaptogyrin-3	229	24555	8.42	4	Synaptic vesicle membrane;Synapse;Cell membrane	NA	May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal.	NA	Belongs to the synaptogyrin family.	NA	PE1	16
+NX_O43763	T-cell leukemia homeobox protein 2	284	30251	11.09	0	Nucleoplasm;Nucleus	NA	Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).	NA	NA	NA	PE1	2
+NX_O43765	Small glutamine-rich tetratricopeptide repeat-containing protein alpha	313	34063	4.81	0	Cytoplasm;Nucleoplasm;Nucleus	NA	(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).;Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).	NA	Belongs to the SGT family.	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	19
+NX_O43766	Lipoyl synthase, mitochondrial	372	41911	8.84	0	Nucleoplasm;Cytosol;Mitochondrion	Hyperglycinemia, lactic acidosis, and seizures	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	NA	Belongs to the radical SAM superfamily. Lipoyl synthase family.	Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.;Lipoic acid metabolism;Metabolic pathways;Glyoxylate metabolism and glycine degradation	PE1	4
+NX_O43768	Alpha-endosulfine	121	13389	6.62	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Cytoskeleton	NA	Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.	Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.	Belongs to the endosulfine family.	MASTL Facilitates Mitotic Progression	PE1	1
+NX_O43772	Mitochondrial carnitine/acylcarnitine carrier protein	301	32944	9.48	6	Cytosol;Mitochondrion inner membrane;Mitochondrion	Carnitine-acylcarnitine translocase deficiency	Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Import of palmitoyl-CoA into the mitochondrial matrix	PE1	3
+NX_O43776	Asparagine--tRNA ligase, cytoplasmic	548	62943	5.9	0	Cytoplasm;Cytosol	NA	NA	NA	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation	PE1	18
+NX_O43781	Dual specificity tyrosine-phosphorylation-regulated kinase 3	588	65714	9.41	0	Cytoplasm;Nucleus speckle;Nucleoplasm;Centrosome;Cytosol;Cytoplasmic granule;Nucleus	NA	Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:9748265, PubMed:29634919). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603).	Protein kinase activity is activated following autophosphorylation at Tyr-369 (Probable). Autophosphorylation at Ser-350 stabilizes the protein and enhances the protein kinase activity (PubMed:9748265).;Ubiquitinated at anaphase by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome.;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.	NA	PE1	1
+NX_O43790	Keratin, type II cuticular Hb6	486	53501	5.56	0	Cytosol	Monilethrix	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_O43791	Speckle-type POZ protein	374	42132	5.58	0	Nucleus speckle;Nucleus	NA	Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL.	NA	Belongs to the Tdpoz family.	Protein modification; protein ubiquitination.;Hedgehog 'on' state	PE1	17
+NX_O43795	Unconventional myosin-Ib	1136	131985	9.43	0	Cell membrane	NA	Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	2
+NX_O43805	Sjoegren syndrome nuclear autoantigen 1	119	13596	5.37	0	Centrosome;Nucleus	NA	NA	NA	Belongs to the SSNA1 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	9
+NX_O43808	Peroxisomal membrane protein PMP34	307	34567	10.09	6	Peroxisome membrane;Cytoplasm;Peroxisome	NA	Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Peroxisome;Alpha-oxidation of phytanate;Class I peroxisomal membrane protein import	PE1	22
+NX_O43809	Cleavage and polyadenylation specificity factor subunit 5	227	26227	8.85	0	Cytoplasm;Centrosome;Centriolar satellite;Nucleus	NA	Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:15937220, PubMed:17024186, PubMed:17098938, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:17098938, PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:17098938, PubMed:20695905, PubMed:29276085). NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7 (PubMed:29276085). Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing (PubMed:8626397, PubMed:14690600, PubMed:15169763, PubMed:17024186, PubMed:22813749, PubMed:20479262). The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA (PubMed:20479262, PubMed:21295486). Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function (By similarity). Binds to chromatin (By similarity). Binds to, but does not hydrolyze mono- and di-adenosine nucleotides (PubMed:18445629).	Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT2.	Belongs to the Nudix hydrolase family. CPSF5 subfamily.	mRNA surveillance pathway;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	16
+NX_O43812	Double homeobox protein 1	170	19347	11.17	0	Nucleus	NA	Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'.	NA	Belongs to the paired homeobox family.	NA	PE1	10
+NX_O43813	Glutathione S-transferase LANCL1	399	45283	7.86	0	Cytoplasm;Cell membrane;Cytoskeleton	NA	Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316).	NA	Belongs to the LanC-like protein family.	NA	PE1	2
+NX_O43815	Striatin	780	86132	5.12	0	Cytoplasm;Dendritic spine;Membrane;Nucleoplasm;Cytosol	NA	Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.	NA	Belongs to the WD repeat striatin family.	PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Extra-nuclear estrogen signaling	PE1	2
+NX_O43818	U3 small nucleolar RNA-interacting protein 2	475	51841	7.97	0	Nucleoplasm;Nucleolus	NA	Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA.	NA	Belongs to the WD repeat RRP9 family.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	3
+NX_O43819	Protein SCO2 homolog, mitochondrial	266	29810	9.01	1	Mitochondrion inner membrane;Mitochondrion	Leigh syndrome;Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1;Myopia 6	Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15229189, PubMed:17189203). Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2 (PubMed:19336478).	NA	Belongs to the SCO1/2 family.	Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	22
+NX_O43820	Hyaluronidase-3	417	46501	8.55	0	Cell membrane;Early endosome;Secreted;Endoplasmic reticulum;Acrosome	NA	Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.	N-glycosylated.	Belongs to the glycosyl hydrolase 56 family.	Glycosaminoglycan degradation;Metabolic pathways;Hyaluronan uptake and degradation;CS/DS degradation	PE1	3
+NX_O43822	Cilia- and flagella-associated protein 410	256	28340	6.97	0	Cytoplasm;Mitochondrion;Photoreceptor outer segment;Cilium basal body;Cytoplasmic vesicle;Cytosol	Retinal dystrophy with or without macular staphyloma;Spondylometaphyseal dysplasia, axial	Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490).	NA	NA	NA	PE1	21
+NX_O43823	A-kinase anchor protein 8	692	76108	5.03	0	Cytoplasm;Nucleus matrix;Nucleolus;Nucleoplasm;Nucleus	NA	Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity).	Phosphorylated on tyrosine residues probably by SRC subfamily protein kinases; multiple phosphorylation is leading to dissociation from nuclear structures implicated in chromatin structural changes.	Belongs to the AKAP95 family.	NA	PE1	19
+NX_O43824	Putative GTP-binding protein 6	516	56897	9.49	0	Mitochondrion	NA	NA	NA	Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.	NA	PE1	X
+NX_O43825	Beta-1,3-galactosyltransferase 2	422	49213	9.5	1	Golgi apparatus membrane;Cell membrane;Cytoskeleton	NA	Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Lewis blood group biosynthesis	PE1	1
+NX_O43826	Glucose-6-phosphate exchanger SLC37A4	429	46360	8.85	10	Endoplasmic reticulum membrane;Mitochondrion	Glycogen storage disease 1B;Glycogen storage disease 1D;Glycogen storage disease 1C	Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.	NA	Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.	Carbohydrate digestion and absorption;Gluconeogenesis;Glycogen storage disease type Ib (SLC37A4)	PE1	11
+NX_O43827	Angiopoietin-related protein 7	346	40018	7.98	0	Secreted	NA	NA	NA	NA	NA	PE1	1
+NX_O43829	Zinc finger and BTB domain-containing protein 14	449	50956	5.69	0	Nucleoplasm;Nucleus	NA	Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	18
+NX_O43837	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	385	42184	8.64	0	Mitochondrion	Retinitis pigmentosa 46	Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.	NA	Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Citrate cycle (TCA cycle);Metabolic pathways;Citric acid cycle (TCA cycle)	PE1	20
+NX_O43847	Nardilysin	1151	131701	4.88	0	Nucleoplasm	NA	Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	NA	Belongs to the peptidase M16 family.	NA	PE1	1
+NX_O43852	Calumenin	315	37107	4.47	0	Golgi apparatus;Endoplasmic reticulum membrane;Secreted;Endoplasmic reticulum;Melanosome;Sarcoplasmic reticulum lumen	NA	Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).	NA	Belongs to the CREC family.	Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	7
+NX_O43854	EGF-like repeat and discoidin I-like domain-containing protein 3	480	53765	7.08	0	Secreted	NA	Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.	NA	NA	NA	PE1	5
+NX_O43861	Probable phospholipid-transporting ATPase IIB	1147	129304	7.67	10	trans-Golgi network membrane	NA	NA	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases	PE1	18
+NX_O43865	S-adenosylhomocysteine hydrolase-like protein 1	530	58951	6.49	0	Endoplasmic reticulum;Apical cell membrane;Microsome;Cytosol	NA	Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity).	Phosphorylated at Ser/Thr residues between Ser-68 and Thr-72 in the PEST region: required for interaction with dATP-bound RRM1 and ITPR1. Phosphorylation at Ser-68 by PRKD1 and CAMK4 is required for further phosphorylations by CSNK1A1 (PubMed:16793548). Phosphorylation is induced by oxidative stress (PubMed:19224921). Probably phosphorylated by CAMK2A; phosphorylation at Ser-68 may be required for interaction with SLC9A3 (PubMed:20584908).	Belongs to the adenosylhomocysteinase family.	Cysteine and methionine metabolism;Metabolic pathways;FCERI mediated Ca+2 mobilization;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;VEGFR2 mediated cell proliferation;Regulation of insulin secretion;PLC beta mediated events;CLEC7A (Dectin-1) induces NFAT activation;DAG and IP3 signaling;Ion homeostasis	PE1	1
+NX_O43866	CD5 antigen-like	347	38088	5.28	0	Cytoplasm;Secreted	NA	Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).	Not N-glycosylated (PubMed:23236605). Probably not O-glycosylated (PubMed:23236605).	NA	NA	PE1	1
+NX_O43868	Sodium/nucleoside cotransporter 2	658	71926	8.29	14	Membrane	NA	Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.	NA	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	PE1	15
+NX_O43869	Olfactory receptor 2T1	369	41996	8.71	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	1
+NX_O43889	Cyclic AMP-responsive element-binding protein 3	371	41379	4.82	1	Golgi apparatus;Cytoplasm;Endoplasmic reticulum membrane;Cytosol;Nucleus	NA	(Microbial infection) Processed cyclic AMP-responsive element-binding protein 3: It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator HCV core protein.;(Microbial infection) Isoform 1: Plays a role in herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestering host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection.;Processed cyclic AMP-responsive element-binding protein 3: This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many promoters to activate transcription of the genes. Binds to the unfolded protein response element (UPRE) consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3').;(Microbial infection) Isoform 1: May play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HCV) core protein.;(Microbial infection) Plays a role in human immunodeficiency virus type 1 (HIV-1) virus protein expression.;Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells.;(Microbial infection) Processed cyclic AMP-responsive element-binding protein 3: Activates transcription of genes required for reactivation of the latent HSV-1 virus. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16. Binds DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many viral promoters.;Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180). Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PubMed:15845366, PubMed:16940180). Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PubMed:19779205, PubMed:15001559, PubMed:17296613). Associates with chromatin to the HERPUD1 promoter (PubMed:16940180). Also induces transcriptional activation of chemokine receptors (PubMed:18587271, PubMed:17296613).	N-glycosylated.;First proteolytically cleaved by site-1 protease (S1P) that generates membrane-associated N-terminus and a luminal C-terminus forms. The membrane-associated N-terminus form is further proteolytically processed probably by the site-2 protease (S2P) through a regulated intramembrane proteolysis (RIP), releasing the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form, which is transported to the nucleus. The proteolytic cleavage is strongly induced during dendritic cell (DC) maturation and inhibited by DCSTAMP. That form is rapidly degraded.	Belongs to the bZIP family. ATF subfamily.	Cholinergic synapse;Dopaminergic synapse;Melanogenesis;Vasopressin-regulated water reabsorption;Huntington's disease;Prostate cancer;CREB3 factors activate genes	PE1	9
+NX_O43895	Xaa-Pro aminopeptidase 2	674	75625	5.69	0	Cytosol;Cell membrane	Angioedema induced by ACE inhibitors	Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.	N-glycosylated.	Belongs to the peptidase M24B family.	Protein digestion and absorption;Post-translational modification: synthesis of GPI-anchored proteins	PE1	X
+NX_O43896	Kinesin-like protein KIF1C	1103	122947	6.47	0	Cytoskeleton	Spastic ataxia 2, autosomal recessive	Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.	Phosphorylated on tyrosine residues.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	17
+NX_O43897	Tolloid-like protein 1	1013	114709	5.69	0	Cytoplasmic vesicle;Secreted	Atrial septal defect 6	Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.	NA	NA	Degradation of the extracellular matrix;Collagen biosynthesis and modifying enzymes;Crosslinking of collagen fibrils;Anchoring fibril formation	PE1	4
+NX_O43900	Prickle planar cell polarity protein 3	615	68609	8.24	0	Cytoplasm;Cell membrane	NA	Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).	NA	Belongs to the prickle / espinas / testin family.	NA	PE1	X
+NX_O43903	Growth arrest-specific protein 2	313	34945	8.76	0	Cell membrane;Nucleolus;Membrane;Nucleoplasm;Stress fiber;Cytosol	NA	May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).	Cleaved, during apoptosis, on a specific aspartic residue by caspases.;Phosphorylated on serine residues during the G0-G1 transition phase.	Belongs to the GAS2 family.	Caspase-mediated cleavage of cytoskeletal proteins	PE1	11
+NX_O43908	NKG2-F type II integral membrane protein	158	18234	9.28	1	Membrane	NA	May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.	NA	NA	Antigen processing and presentation	PE2	12
+NX_O43909	Exostosin-like 3	919	104749	6.08	1	Golgi apparatus;Endoplasmic reticulum membrane	Immunoskeletal dysplasia with neurodevelopmental abnormalities	Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) (PubMed:28132690, PubMed:28148688). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (PubMed:22727489).	NA	Belongs to the glycosyltransferase 47 family.	Glycan metabolism; heparan sulfate biosynthesis.;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;XBP1(S) activates chaperone genes	PE1	8
+NX_O43913	Origin recognition complex subunit 5	435	50283	7.63	0	Nucleoplasm;Cytosol;Chlorosome;Nucleus	NA	Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle.	Belongs to the ORC5 family.	Cell cycle;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;Activation of ATR in response to replication stress;CDC6 association with the ORC:origin complex;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;E2F-enabled inhibition of pre-replication complex formation;Assembly of the ORC complex at the origin of replication	PE1	7
+NX_O43914	TYRO protein tyrosine kinase-binding protein	113	12179	8.55	1	Cell membrane	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1	Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (PubMed:9490415, PubMed:9655483, PubMed:10604985). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (PubMed:9490415). Also has an inhibitory role in some cells (PubMed:21727189). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (PubMed:15557162, PubMed:16920917, PubMed:17928527; PubMed:26221034). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (PubMed:10449773). Associates with natural killer (NK) cell receptors such as KIR2DS2 and the KLRD1/KLRC2 heterodimer to mediate NK cell activation (PubMed:9490415, PubMed:9655483, PubMed:23715743). Also enhances trafficking and cell surface expression of NK cell receptors KIR2DS1, KIR2DS2 and KIR2DS4 and ensures their stability at the cell surface (PubMed:23715743). Associates with SIRPB1 to mediate activation of myeloid cells such as monocytes and dendritic cells (PubMed:10604985). Associates with TREM1 to mediate activation of neutrophils and monocytes (PubMed:10799849). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (PubMed:18957693). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (PubMed:25957402). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes proinflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). Positively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allostimulatory ability (By similarity). Negatively regulates B cell proliferation (PubMed:21727189). Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity).	Following ligand binding by associated receptors, tyrosine phosphorylated in the ITAM domain which leads to activation of additional tyrosine kinases and subsequent cell activation.;TYROBP is phosphorylated by LCK (Phosphotyrosine:PTM-0255)	Belongs to the TYROBP family.	Osteoclast differentiation;Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 signaling;Other semaphorin interactions;Signal regulatory protein family interactions;DAP12 interactions;Neutrophil degranulation	PE1	19
+NX_O43915	Vascular endothelial growth factor D	354	40444	8.16	0	Secreted	NA	Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.	Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.	Belongs to the PDGF/VEGF growth factor family.	Cytokine-cytokine receptor interaction;mTOR signaling pathway;Focal adhesion;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Bladder cancer;Platelet degranulation;VEGF ligand-receptor interactions;VEGF binds to VEGFR leading to receptor dimerization	PE1	X
+NX_O43916	Carbohydrate sulfotransferase 1	411	46715	9.17	1	Golgi apparatus membrane	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.	NA	Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.	Glycosaminoglycan biosynthesis - keratan sulfate;Keratan sulfate biosynthesis	PE1	11
+NX_O43918	Autoimmune regulator	545	57727	7.53	0	Cytoplasm;Nucleus	Autoimmune polyendocrine syndrome 1, with or without reversible metaphyseal dysplasia	Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (PubMed:26084028). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program. Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression. Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes. In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection. In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (By similarity).	Phosphorylated. Phosphorylation could trigger oligomerization.	NA	Ubiquitin mediated proteolysis;Primary immunodeficiency	PE1	21
+NX_O43920	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	106	12518	9.27	0	Mitochondrion intermembrane space;Mitochondrion inner membrane	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFS5 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	1
+NX_O43921	Ephrin-A2	213	23878	6.99	0	Cytosol;Mitochondrion;Cell membrane	NA	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).	NA	Belongs to the ephrin family.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	19
+NX_O43924	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	150	17420	5.57	0	Cytoplasmic vesicle membrane;Cytosol;Cilium basal body	Joubert syndrome 22	Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).	NA	Belongs to the PDE6D/unc-119 family.	Purine metabolism;ARL13B-mediated ciliary trafficking of INPP5E	PE1	2
+NX_O43927	C-X-C motif chemokine 13	109	12664	10.35	0	Secreted	NA	Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.	NA	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	4
+NX_O43929	Origin recognition complex subunit 4	436	50377	8.08	0	Nucleoplasm;Nucleus;Nucleolus	Meier-Gorlin syndrome 2	Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.	NA	Belongs to the ORC4 family.	Cell cycle;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;Activation of ATR in response to replication stress;CDC6 association with the ORC:origin complex;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;E2F-enabled inhibition of pre-replication complex formation;Assembly of the ORC complex at the origin of replication	PE1	2
+NX_O43930	Putative serine/threonine-protein kinase PRKY	277	31708	6.46	0	NA	NA	NA	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.	NA	PE5	Y
+NX_O43933	Peroxisome biogenesis factor 1	1283	142867	5.91	0	Peroxisome membrane;Cytoplasm;Peroxisome	Peroxisome biogenesis disorder 1B;Peroxisome biogenesis disorder complementation group 1;Heimler syndrome 1;Peroxisome biogenesis disorder 1A	Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.	NA	Belongs to the AAA ATPase family.	Peroxisome;Peroxisomal protein import	PE1	7
+NX_O43934	UNC93-like protein MFSD11	449	49202	5.48	12	Membrane;Nucleus speckle	NA	NA	NA	Belongs to the unc-93 family.	NA	PE1	17
+NX_O60216	Double-strand-break repair protein rad21 homolog	631	71690	4.54	0	Nucleus matrix;Chromosome;Nucleoplasm;Spindle pole;Centromere;Cytosol;Nucleus	Cornelia de Lange syndrome 4;Mungan syndrome	64-kDa C-terminal product: May promote apoptosis.;Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity).	Cleaved by separase/ESPL1 at the onset of anaphase; this cleavage is required for sister chromatid separation and cytokinesis (PubMed:11509732). Cleaved by caspase-3/CASP3 or caspase-7/CASP7 at the beginning of apoptosis (PubMed:12417729, PubMed:11875078).;Phosphorylated; becomes hyperphosphorylated in M phase of cell cycle. The large dissociation of cohesin from chromosome arms during prophase may be partly due to its phosphorylation by PLK1.	Belongs to the rad21 family.	Cell cycle;Separation of Sister Chromatids;SUMOylation of DNA damage response and repair proteins;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion;Meiotic synapsis;Estrogen-dependent gene expression	PE1	8
+NX_O60218	Aldo-keto reductase family 1 member B10	316	36020	7.66	0	Secreted;Lysosome	NA	Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097).	NA	Belongs to the aldo/keto reductase family.	Cofactor metabolism; retinol metabolism.;Fructose and mannose metabolism;Linoleic acid metabolism;Butanoate metabolism;Metabolic pathways;Retinoid metabolism and transport	PE1	7
+NX_O60220	Mitochondrial import inner membrane translocase subunit Tim8 A	97	10998	5.08	0	Mitochondrion inner membrane;Mitochondrion	Mohr-Tranebjaerg syndrome	Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.	NA	Belongs to the small Tim family.	Mitochondrial protein import	PE1	X
+NX_O60224	Protein SSX4	188	21858	9.16	0	NA	NA	Could act as a modulator of transcription.	NA	Belongs to the SSX family.	NA	PE1	X
+NX_O60225	Protein SSX5	188	21660	9.35	0	NA	NA	Could act as a modulator of transcription.	NA	Belongs to the SSX family.	NA	PE1	X
+NX_O60229	Kalirin	2986	340261	5.72	0	Nucleoplasm;Cytosol;Cytoplasm;Cytoskeleton	Coronary heart disease 5	Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.	Autophosphorylated.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	MAPK6/MAPK4 signaling;G alpha (q) signalling events;EPHB-mediated forward signaling;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	3
+NX_O60231	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16	1041	119264	6.39	0	Nucleoplasm;Nucleus	NA	Required for pre-mRNA splicing as component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction.	NA	Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.	Spliceosome;mRNA Splicing - Major Pathway	PE1	6
+NX_O60232	Protein ZNRD2	199	21474	5.12	0	Cytosol	NA	Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.	NA	NA	NA	PE1	11
+NX_O60234	Glia maturation factor gamma	142	16801	5.18	0	NA	NA	NA	NA	Belongs to the actin-binding proteins ADF family. GMF subfamily.	Neutrophil degranulation	PE1	19
+NX_O60235	Transmembrane protease serine 11D	418	46263	8.69	1	Secreted;Cell membrane	NA	May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.	NA	Belongs to the peptidase S1 family.	NA	PE1	4
+NX_O60237	Protein phosphatase 1 regulatory subunit 12B	982	110404	5.53	0	Stress fiber;Cell membrane;Cytoskeleton	NA	Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.	NA	NA	Vascular smooth muscle contraction;Regulation of PLK1 Activity at G2/M Transition;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs	PE1	1
+NX_O60238	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like	219	23930	5.52	1	Mitochondrion outer membrane;Cytoplasm;Nucleus speckle;Mitochondrion;Membrane;Endoplasmic reticulum;Nucleus envelope;Nucleus	NA	Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.	Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.	Belongs to the NIP3 family.	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	PE1	8
+NX_O60239	SH3 domain-binding protein 5	455	50425	4.92	0	Cytoplasmic vesicle membrane;Nucleoplasm;Mitochondrion;Nucleus	NA	Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.	SH3BP5 is phosphorylated by MAPK10 (Phosphoserine:PTM-0253)	Belongs to the SH3BP5 family.	NA	PE1	3
+NX_O60240	Perilipin-1	522	55990	6.03	0	Endoplasmic reticulum;Peroxisome;Lipid droplet	Lipodystrophy, familial partial, 4	Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.	Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity).	Belongs to the perilipin family.	PPAR signaling pathway;Triglyceride catabolism;Transcriptional regulation of white adipocyte differentiation	PE1	15
+NX_O60241	Adhesion G protein-coupled receptor B2	1585	172656	7.5	7	Centrosome;Cell membrane	NA	Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity).	Glycosylated.;Autoproteolytic processes at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	1
+NX_O60242	Adhesion G protein-coupled receptor B3	1522	171518	6.69	7	Cell membrane	NA	Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399).	The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	6
+NX_O60243	Heparan-sulfate 6-O-sulfotransferase 1	411	48226	9.04	1	Membrane;Nucleoplasm;Nucleus speckle	Hypogonadotropic hypogonadism 15 with or without anosmia	6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid.	N-glycosylated.	Belongs to the sulfotransferase 6 family.	Glycosaminoglycan biosynthesis - heparan sulfate;HS-GAG biosynthesis	PE1	2
+NX_O60244	Mediator of RNA polymerase II transcription subunit 14	1454	160607	8.97	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 14 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	X
+NX_O60245	Protocadherin-7	1069	116071	5.02	1	Cell junction;Cell membrane	NA	NA	NA	NA	Platelet degranulation	PE1	4
+NX_O60248	Protein SOX-15	233	25251	9.78	0	Golgi apparatus;Nucleolus;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	Binds to the 5'-AACAAT-3' sequence.	NA	NA	NA	PE1	17
+NX_O60256	Phosphoribosyl pyrophosphate synthase-associated protein 2	369	40926	7.08	0	Nucleoplasm;Cytosol	NA	Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.	NA	Belongs to the ribose-phosphate pyrophosphokinase family.	NA	PE1	17
+NX_O60258	Fibroblast growth factor 17	216	24891	10.43	0	Secreted	Hypogonadotropic hypogonadism 20 with or without anosmia	Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR1;Signaling by activated point mutants of FGFR3;FGFR4 ligand binding and activation;FGFR3c ligand binding and activation;FGFR1c ligand binding and activation;FGFR2c ligand binding and activation;FGFR3 mutant receptor activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;Phospholipase C-mediated cascade, FGFR4;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;FGFR3b ligand binding and activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;FGFRL1 modulation of FGFR1 signaling;Signaling by FGFR3 point mutants in cancer	PE1	8
+NX_O60259	Kallikrein-8	260	28048	7.52	0	Cytoplasm;Secreted;Cytoplasmic vesicle	NA	Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.	NA	Belongs to the peptidase S1 family. Kallikrein subfamily.	Formation of the cornified envelope	PE1	19
+NX_O60260	E3 ubiquitin-protein ligase parkin	465	51641	6.71	0	Nucleus speckle;Mitochondrion;Endoplasmic reticulum;Cytosol;Nucleus	Parkinson disease;Parkinson disease 2	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536, PubMed:29311685). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11590439, PubMed:11431533, PubMed:19229105, PubMed:11590439, PubMed:15728840). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains following mitochondrial damage, leading to mitophagy (PubMed:25621951). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death (PubMed:21376232). Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.	Auto-ubiquitinates in an E2-dependent manner leading to its own degradation (PubMed:19229105). Also polyubiquitinated by RNF41 for proteasomal degradation.;Phosphorylation at Ser-65 by PINK1 contributes to activate PRKN activity. It is however not sufficient and requires binding to phosphorylated ubiquitin as well.;S-nitrosylated. The inhibition of PRKN ubiquitin E3 ligase activity by S-nitrosylation could contribute to the degenerative process in PD by impairing the ubiquitination of PRKN substrates.	Belongs to the RBR family. Parkin subfamily.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Parkinson's disease;Antigen processing: Ubiquitination & Proteasome degradation;Amyloid fiber formation;Pink/Parkin Mediated Mitophagy;Josephin domain DUBs	PE1	6
+NX_O60262	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	68	7522	8.71	0	Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).	NA	Belongs to the G protein gamma family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	19
+NX_O60264	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5	1052	121905	8.27	0	Nucleoplasm;Nucleus;Nucleolus	NA	Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.	NA	Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.	NoRC negatively regulates rRNA expression;Deposition of new CENPA-containing nucleosomes at the centromere;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;B-WICH complex positively regulates rRNA expression	PE1	4
+NX_O60266	Adenylate cyclase type 3	1144	128960	6.15	12	Golgi apparatus;Cytoplasm;Cilium;Cell membrane	Obesity	Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.	N-glycosylated.;Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity.;Sumoylated. Sumoylation is required for targeting ot olfactory cilia.	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Calcium signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Olfactory transduction;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Vasopressin-regulated water reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;Vibrio cholerae infection;HTLV-I infection;G alpha (i) signalling events;G alpha (s) signalling events;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G alpha (z) signalling events;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway	PE1	2
+NX_O60268	Uncharacterized protein KIAA0513	411	46639	4.98	0	Nucleoplasm;Cytosol;Cytoplasm	NA	NA	NA	NA	NA	PE1	16
+NX_O60269	G protein-regulated inducer of neurite outgrowth 2	458	47450	6.28	0	NA	NA	May be involved in neurite outgrowth.	NA	NA	NA	PE1	10
+NX_O60271	C-Jun-amino-terminal kinase-interacting protein 4	1321	146205	5.05	0	Cytoplasm;Lysosome membrane;Centriolar satellite;Cytosol;Perinuclear region;Acrosome	NA	May play a role in spermatozoa-egg-interaction (PubMed:15693750). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937).;The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216).	Phosphorylated by MAPK8 and MAPK14.	Belongs to the JIP scaffold family.	Myogenesis	PE1	17
+NX_O60279	Sushi domain-containing protein 5	629	68021	4.79	1	Membrane;Golgi apparatus;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	3
+NX_O60281	Zinc finger protein 292	2723	304816	7.27	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_O60282	Kinesin heavy chain isoform 5C	957	109495	5.86	0	Cytoplasmic vesicle;Dendrite;Cytoskeleton	Cortical dysplasia, complex, with other brain malformations 2	Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.	Dopaminergic synapse;Insulin processing	PE1	2
+NX_O60284	Suppression of tumorigenicity 18 protein	1047	115155	5.72	0	Nucleus	NA	Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.	NA	Belongs to the MYT1 family.	NA	PE1	8
+NX_O60285	NUAK family SNF1-like kinase 1	661	74305	8.97	0	Cytoplasm;Nucleolus;Nucleoplasm;Nucleus;Cytoskeleton	NA	Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).	Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.;Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not dephosphorylated by the myosin PP1 complex when regulating its activity, due to the presence of PPP1R12A, which prevents myosin PP1 from dephosphorylating NUAK1. Phosphorylated by STK38L upon stimulation with IGF1.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	Regulation of TP53 Activity through Phosphorylation	PE1	12
+NX_O60287	Nucleolar pre-ribosomal-associated protein 1	2271	254389	6.03	0	Nucleolus	NA	NA	NA	NA	NA	PE1	21
+NX_O60290	Zinc finger protein 862	1169	131654	6.87	0	Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	7
+NX_O60291	E3 ubiquitin-protein ligase MGRN1	552	60753	5.01	0	Cell membrane;Early endosome;Cytoplasmic vesicle;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).	Autoubiquitinated in vitro.	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination & Proteasome degradation	PE1	16
+NX_O60292	Signal-induced proliferation-associated 1-like protein 3	1781	194610	8.57	0	Golgi apparatus;Nucleoplasm;Apical cell membrane;Cell membrane	Cataract 45	Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217).	NA	NA	NA	PE1	19
+NX_O60293	Zinc finger C3H1 domain-containing protein	1989	226356	8.39	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.	NA	NA	NA	PE1	12
+NX_O60294	tRNA wybutosine-synthesizing protein 4	686	75602	6.25	0	Cytoplasmic vesicle;Nucleoplasm	NA	Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.	NA	Belongs to the methyltransferase superfamily. LCMT family.	tRNA modification; wybutosine-tRNA(Phe) biosynthesis.;Synthesis of wybutosine at G37 of tRNA(Phe)	PE1	15
+NX_O60296	Trafficking kinesin-binding protein 2	914	101419	5.15	0	Cytoplasm;Mitochondrion;Early endosome;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.	O-glycosylated.	Belongs to the milton family.	GABAergic synapse	PE1	2
+NX_O60299	Leucine zipper putative tumor suppressor 3	673	71791	7.56	0	Dendritic spine;Postsynaptic density;Synapse;Cytoplasmic vesicle;Dendrite;Cytoskeleton	NA	May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.	NA	Belongs to the LZTS3 family.	NA	PE1	20
+NX_O60303	Protein KIAA0556	1618	180918	5.57	0	Nucleus speckle;Cell membrane;Cilium basal body;Cilium axoneme;Cytoskeleton	Joubert syndrome 26	May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex.	NA	NA	NA	PE1	16
+NX_O60304	Zinc finger protein 500	480	53674	6.84	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_O60306	RNA helicase aquarius	1485	171295	5.96	0	Nucleoplasm;Nucleus	NA	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396).	NA	Belongs to the CWF11 family.	Spliceosome;mRNA Splicing - Major Pathway;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER	PE1	15
+NX_O60307	Microtubule-associated serine/threonine-protein kinase 3	1309	143137	8.24	0	Nucleus speckle	NA	NA	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	NA	PE1	19
+NX_O60308	Centrosomal protein of 104 kDa	925	104448	7.54	0	Spindle pole;Centrosome;Cilium;Centriole	Joubert syndrome 25	Required for ciliogenesis and for structural integrity at the ciliary tip.	NA	NA	NA	PE1	1
+NX_O60309	Leucine-rich repeat-containing protein 37A3	1634	180621	5.2	1	Membrane	NA	NA	NA	Belongs to the LRRC37A family.	NA	PE1	17
+NX_O60312	Probable phospholipid-transporting ATPase VA	1499	167688	8.7	10	Endoplasmic reticulum membrane;Cell membrane	NA	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases	PE1	15
+NX_O60313	Dynamin-like 120 kDa protein, mitochondrial	960	111631	7.87	1	Mitochondrion;Mitochondrion intermembrane space;Nucleoplasm;Mitochondrion membrane;Mitochondrion inner membrane	Dominant optic atrophy plus syndrome;Mitochondrial DNA depletion syndrome 14, cardioencephalomyopathic type;Optic atrophy 1;Behr syndrome	Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.;Isoforms that contain the alternative exon 4b (present in isoform 4 and isoform 5) are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane.;Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317).	PARL-dependent proteolytic processing releases an antiapoptotic soluble form not required for mitochondrial fusion. Cleaved by OMA1 at position S1 following stress conditions.;Cleavage at position S2 is mediated by YME1L (PubMed:17709429, PubMed:24616225, PubMed:27495975). Cleavage may occur in the sequence motif Leu-Gln-Gln-Gln-Ile-Gln (LQQQIQ) (PubMed:16778770). This motif is present in isoform 2, isoform 3, isoform 4 and isoform 7, but is absent in the displayed isoform 1 and in isoform 5.	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Regulation of Apoptosis	PE1	3
+NX_O60315	Zinc finger E-box-binding homeobox 2	1214	136447	5.9	0	Nucleoplasm;Nucleus;Nucleolus;Cytosol	Mowat-Wilson syndrome	Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.	Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.	Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.	NA	PE1	2
+NX_O60318	Germinal-center associated nuclear protein	1980	218405	5.99	0	Cytoplasm;Nuclear pore complex;Nucleus membrane;Chromosome;Nucleoplasm;Nucleus envelope;Cytosol;Nucleus	Peripheral neuropathy, autosomal recessive, with or without impaired intellectual development	Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018).;As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:23591820, PubMed:22307388). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018).	MCM3AP is phosphorylated by CDK2	Belongs to the SAC3 family.	NA	PE1	21
+NX_O60320	Protein FAM189A1	539	56544	5.18	4	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the FAM189 family.	NA	PE2	15
+NX_O60330	Protocadherin gamma-A12	932	100955	4.9	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_O60331	Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	668	73260	5.17	0	Cytoplasm;Cell membrane;Endomembrane system;Adherens junction;Focal adhesion;Nucleoplasm;Uropodium;Phagocytic cup;Ruffle membrane;Cytosol;Nucleus	Lethal congenital contracture syndrome 3	Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion, cell polarization and cell migration. Together with PIP5K1A is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport. Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2). Required for clathrin-coated pits assembly at the synapse. Participates in cell junction assembly. Modulates adherens junctions formation by facilitating CDH1 trafficking. Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions. Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins. Required for uropodium formation and retraction of the cell rear during directed migration. Has a role in growth factor- stimulated directional cell migration and adhesion. Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor. Negative regulator of T-cell activation and adhesion. Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor. Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth.	Acetylation at Lys-265 and Lys-268 seems to decrease lipid kinase activity. Deacetylation of these sites by SIRT1 positively regulates the exocytosis of TSH-containing granules from pituitary cells.;Phosphorylation on Ser-650 negatively regulates binding to TLN2 and is strongly stimulated in mitosis. Phosphorylation on Tyr-649 is necessary for targeting to focal adhesions. Phosphorylation on Ser-650 and Tyr-649 are mutually exclusive. Phosphorylated by SYK and CSK (By similarity). Tyrosine phosphorylation is enhanced by PTK2 signaling. Phosphorylated at Tyr-639 upon EGF stimulation. Some studies suggest that phosphorylation on Tyr-649 enhances binding to tailins (TLN1 and TLN2). According to PubMed:15738269 phosphorylation at Tyr-649 does not directly enhance binding to tailins (TLN1 and TLN2) but may act indirectly by inhibiting phosphorylation at Ser-650.;PIP5K1C is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Endocytosis;Focal adhesion;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Synthesis of PIPs at the plasma membrane;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Clathrin-mediated endocytosis	PE1	19
+NX_O60333	Kinesin-like protein KIF1B	1816	204476	5.42	0	Mitochondrion;Synaptic vesicle;Cytoskeleton	Neuroblastoma 1;Charcot-Marie-Tooth disease 2A1;Pheochromocytoma	Is required for induction of neuronal apoptosis.;Mediates the transport of synaptic vesicles in neuronal cells.;Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	1
+NX_O60336	Mitogen-activated protein kinase-binding protein 1	1514	163818	6.31	0	Cytoplasm;Nucleolus;Nucleoplasm;Spindle pole;Nucleus	Nephronophthisis 20	Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity).	NA	NA	NA	PE1	15
+NX_O60337	E3 ubiquitin-protein ligase MARCH6	910	102545	5.85	14	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (PubMed:15673284). Promotes ubiquitination of DIO2, leading to its degradation (PubMed:19651899). Promotes ubiquitination of SQLE, leading to its degradation (PubMed:24449766). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 (PubMed:15673284).	Auto-ubiquitinated, which results in proteasomal degradation.	NA	Protein modification; protein ubiquitination.;Protein processing in endoplasmic reticulum;ER Quality Control Compartment (ERQC)	PE1	5
+NX_O60341	Lysine-specific histone demethylase 1A	852	92903	6.11	0	Nucleoplasm;Cytosol;Nucleus	Cleft palate, psychomotor retardation, and distinctive facial features	Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16140033, PubMed:16079794, PubMed:16079795, PubMed:16223729). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16140033, PubMed:16079794, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281).	Polyubiquitinated by JADE2; which leads to its proteasomal degradation.	Belongs to the flavin monoamine oxidase family.	Factors involved in megakaryocyte development and platelet production;HDACs deacetylate histones;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;HDMs demethylate histones;Regulation of PTEN gene transcription;Estrogen-dependent gene expression	PE1	1
+NX_O60343	TBC1 domain family member 4	1298	146563	6.57	0	Cytoplasm;Cytosol	Diabetes mellitus, non-insulin-dependent, 5	May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14.;Promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.	Phosphorylated by AKT1; insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization. Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.;TBC1D4 is phosphorylated by WNK1	NA	Translocation of SLC2A4 (GLUT4) to the plasma membrane	PE1	13
+NX_O60346	PH domain leucine-rich repeat-containing protein phosphatase 1	1717	184672	5.88	0	Membrane;Cytoplasm;Nucleus;Cell membrane	NA	Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466).;Seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity).	NA	NA	Negative regulation of the PI3K/AKT network	PE1	18
+NX_O60347	TBC1 domain family member 12	775	85626	5.56	0	Nucleoplasm;Endosome;Nucleus speckle	NA	RAB11A-binding protein that plays a role in neurite outgrowth.	NA	NA	NA	PE1	10
+NX_O60353	Frizzled-6	706	79292	8.29	7	Endoplasmic reticulum membrane;Cell membrane;Membrane;Cell surface;Cytoplasmic vesicle membrane;Apical cell membrane	Nail disorder, non-syndromic congenital, 10	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.	Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Class B/2 (Secretin family receptors);PCP/CE pathway;Ca2+ pathway;Regulation of FZD by ubiquitination;RNF mutants show enhanced WNT signaling and proliferation	PE1	8
+NX_O60356	Nuclear protein 1	82	8873	9.98	0	Nucleoplasm;Cytoplasm;Perinuclear region;Nucleus	NA	Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:16478804, PubMed:19650074, PubMed:16300740, PubMed:19723804, PubMed:11056169, PubMed:22858377, PubMed:11940591, PubMed:18690848, PubMed:22565310, PubMed:20181828, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates to DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity).	Phosphorylated in vitro by PKA and CK. Phosphorylation promotes DNA-binding activity.;Acetylated by EP300 in vitro.	Belongs to the NUPR family.	NA	PE1	16
+NX_O60359	Voltage-dependent calcium channel gamma-3 subunit	315	35549	9.53	4	Membrane	NA	Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.	NA	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Trafficking of AMPA receptors;LGI-ADAM interactions;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	16
+NX_O60361	Putative nucleoside diphosphate kinase	137	15529	8.76	0	NA	NA	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).	NA	Belongs to the NDK family.	Interconversion of nucleotide di- and triphosphates	PE5	12
+NX_O60381	HMG box-containing protein 1	514	57645	5.79	0	Nucleus speckle;Nucleus	NA	Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.	Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex, leading to subsequent proteasomal degradation.	NA	NA	PE1	7
+NX_O60383	Growth/differentiation factor 9	454	51444	9.19	0	Secreted	Premature ovarian failure 14	Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.	Phosphorylated; phosphorylation is critical for GDF9 function. In vitro, can be phosphorylated by CK at Ser-325.	Belongs to the TGF-beta family.	NA	PE1	5
+NX_O60384	Putative zinc finger protein 861	105	11997	8.91	0	NA	NA	NA	NA	NA	NA	PE5	19
+NX_O60391	Glutamate receptor ionotropic, NMDA 3B	1043	112992	9.37	3	Cell membrane;Postsynaptic cell membrane	NA	NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.	NA	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;Assembly and cell surface presentation of NMDA receptors	PE2	19
+NX_O60393	Homeobox protein NOBOX	691	73906	5.79	0	Nucleus	Premature ovarian failure 5	Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'.	NA	NA	NA	PE1	7
+NX_O60397	Putative cytochrome c oxidase subunit 7A3, mitochondrial	106	11841	9.57	0	Mitochondrion inner membrane	NA	NA	NA	Belongs to the cytochrome c oxidase VIIa family.	NA	PE5	4
+NX_O60403	Olfactory receptor 10H2	315	34663	8.71	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_O60404	Olfactory receptor 10H3	316	35721	9.22	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_O60412	Olfactory receptor 7C2	319	35323	7.99	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	19
+NX_O60422	One cut domain family member 3	494	50037	9.9	0	Nucleoplasm;Nucleus	NA	Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity).	NA	Belongs to the CUT homeobox family.	Regulation of gene expression in early pancreatic precursor cells;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	PE1	19
+NX_O60423	Phospholipid-transporting ATPase IK	1300	146752	8.18	10	Acrosome membrane;Endoplasmic reticulum membrane	NA	P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases	PE1	19
+NX_O60427	Acyl-CoA (8-3)-desaturase	444	51964	8.98	4	Endoplasmic reticulum membrane;Mitochondrion	NA	Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity.;Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity).	NA	Belongs to the fatty acid desaturase type 1 family.	Lipid metabolism; polyunsaturated fatty acid biosynthesis.;Biosynthesis of unsaturated fatty acids;PPARA activates gene expression;Linoleic acid (LA) metabolism;alpha-linolenic acid (ALA) metabolism	PE1	11
+NX_O60431	Olfactory receptor 1I1	355	39297	7.14	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_O60437	Periplakin	1756	204747	5.47	0	Desmosome;Mitochondrion;Cell membrane;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.	NA	Belongs to the plakin or cytolinker family.	Formation of the cornified envelope;Butyrophilin (BTN) family interactions	PE1	16
+NX_O60443	Gasdermin-E	496	54555	5.03	0	Cytosol;Cell membrane	Deafness, autosomal dominant, 5	Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (PubMed:16897187, PubMed:18223688).;Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis (PubMed:28459430, PubMed:27281216). Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:28459430). Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents (PubMed:28045099). Exhibits bactericidal activity (PubMed:27281216).	Cleavage at Asp-270 by CASP3 (mature and uncleaved precursor forms) relieves autoinhibition and is sufficient to initiate pyroptosis.	Belongs to the gasdermin family.	NA	PE1	7
+NX_O60447	Ecotropic viral integration site 5 protein homolog	810	92949	5.78	0	Spindle;Centrosome;Nucleus	NA	Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.	Ubiquitinated. Degradation during prophase is ubiquitin-dependent.;Probably phosphorylated by PLK1; may be required for degradation during mitosis.;EVI5 is phosphorylated by PLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	1
+NX_O60449	Lymphocyte antigen 75	1722	198311	6.22	1	Membrane;Golgi apparatus	NA	Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.	N-glycosylated.	NA	NA	PE1	2
+NX_O60462	Neuropilin-2	931	104831	5.04	1	Membrane;Cytoplasmic vesicle;Secreted;Cell membrane	NA	High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.;(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.	NA	Belongs to the neuropilin family.	NrCAM interactions;Neurophilin interactions with VEGF and VEGFR	PE1	2
+NX_O60469	Down syndrome cell adhesion molecule	2012	222260	7.78	1	Cell membrane;Growth cone;Secreted;Nucleoplasm;Synapse;Cytosol;Axon;Dendrite	NA	Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).	Phosphorylated at tyrosine residues. Phosphorylation is enhanced by NTN1.	NA	DSCAM interactions	PE1	21
+NX_O60476	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB	641	73004	7.17	1	Golgi apparatus;Golgi apparatus membrane	NA	Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).	NA	Belongs to the glycosyl hydrolase 47 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2;Intra-Golgi traffic	PE1	1
+NX_O60477	BMP/retinoic acid-inducible neural-specific protein 1	761	88760	9.15	0	Cytoplasm;Cytoskeleton	NA	Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.	NA	Belongs to the BRINP family.	NA	PE1	9
+NX_O60478	Integral membrane protein GPR137B	399	45599	8.95	7	Lysosome membrane	NA	NA	NA	Belongs to the GPR137 family.	NA	PE1	1
+NX_O60479	Homeobox protein DLX-3	287	31738	8.98	0	Nucleus	Amelogenesis imperfecta 4;Trichodentoosseous syndrome	Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.	NA	Belongs to the distal-less homeobox family.	NA	PE1	17
+NX_O60481	Zinc finger protein ZIC 3	467	50569	8.89	0	Nucleoplasm;Cytoplasm;Nucleus	Heterotaxy, visceral, 1, X-linked;VACTERL association X-linked with or without hydrocephalus;Congenital heart defects, multiple types, 1, X-linked	Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.	NA	Belongs to the GLI C2H2-type zinc-finger protein family.	Transcriptional regulation of pluripotent stem cells;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	PE1	X
+NX_O60486	Plexin-C1	1568	175742	7.78	1	Membrane;Mitochondrion	NA	Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).	N-glycosylated.	Belongs to the plexin family.	Axon guidance;Other semaphorin interactions	PE1	12
+NX_O60487	Myelin protein zero-like protein 2	215	24484	6.53	1	Membrane;Cell junction	Deafness, autosomal recessive, 111	Mediates homophilic cell-cell adhesion.	NA	Belongs to the myelin P0 protein family.	NA	PE1	11
+NX_O60488	Long-chain-fatty-acid--CoA ligase 4	711	79188	8.66	1	Microsome membrane;Golgi apparatus;Mitochondrion outer membrane;Endoplasmic reticulum membrane;Mitochondrion;Cell membrane;Peroxisome membrane	Alport syndrome with mental retardation, midface hypoplasia and elliptocytosis;Mental retardation, X-linked 63	Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Fatty acid metabolism;Metabolic pathways;PPAR signaling pathway;Peroxisome;Adipocytokine signaling pathway;Synthesis of very long-chain fatty acyl-CoAs;Intracellular metabolism of fatty acids regulates insulin secretion	PE1	X
+NX_O60493	Sorting nexin-3	162	18762	8.71	0	Cytoplasm;Early endosome;Phagosome	NA	Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).	Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10 (By similarity).	Belongs to the sorting nexin family.	WNT ligand biogenesis and trafficking;Ub-specific processing proteases	PE1	6
+NX_O60494	Cubilin	3623	398736	5.14	0	Cell membrane;Coated pit;Lysosome membrane;Endosome;Apical cell membrane	Recessive hereditary megaloblastic anemia 1	Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed:9572993, PubMed:10371504, PubMed:11717447, PubMed:11606717, PubMed:14576052). Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex (PubMed:9572993, PubMed:14576052). Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium (PubMed:9572993). Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.	The precursor is cleaved by a trans-Golgi proteinase furin, removing a propeptide.;N-glycosylated.	NA	Vitamin digestion and absorption;Cobalamin (Cbl, vitamin B12) transport and metabolism;Vitamin D (calciferol) metabolism;Defective AMN causes hereditary megaloblastic anemia 1;Defective CUBN causes hereditary megaloblastic anemia 1;HDL clearance	PE1	10
+NX_O60496	Docking protein 2	412	45379	5.78	0	NA	NA	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).	On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity).;DOK2 is phosphorylated by TEK (Phosphotyrosine:PTM-0255)	Belongs to the DOK family. Type A subfamily.	Tie2 Signaling;RET signaling	PE1	8
+NX_O60499	Syntaxin-10	249	28114	4.81	1	Golgi apparatus;Golgi apparatus membrane	NA	SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.	NA	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;Retrograde transport at the Trans-Golgi-Network	PE1	19
+NX_O60500	Nephrin	1241	134742	5.42	1	Cell membrane	Nephrotic syndrome 1	Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity).	Phosphorylated at Tyr-1193 by FYN, leading to the recruitment and activation of phospholipase C-gamma-1/PLCG1.	Belongs to the immunoglobulin superfamily.	Nephrin family interactions	PE1	19
+NX_O60502	Protein O-GlcNAcase	916	102915	4.82	0	Cytoplasm;Cytosol;Nucleus	NA	Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.;Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).	Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.	Belongs to the glycosyl hydrolase 84 family.	NA	PE1	10
+NX_O60503	Adenylate cyclase type 9	1353	150701	7.07	12	Cytosol;Cell membrane	NA	Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).	NA	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Calcium signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Vasopressin-regulated water reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;Vibrio cholerae infection;HTLV-I infection;G alpha (i) signalling events;G alpha (s) signalling events;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G alpha (z) signalling events;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway	PE1	16
+NX_O60504	Vinexin	671	75341	9.48	0	Cell junction;Focal adhesion;Cytosol;Nucleus;Cytoskeleton	NA	Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.	Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading.	NA	Smooth Muscle Contraction	PE1	8
+NX_O60506	Heterogeneous nuclear ribonucleoprotein Q	623	69603	8.68	0	Cytoplasm;Microsome;Endoplasmic reticulum;Nucleoplasm;Cytosol;Nucleus	NA	Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability.;Are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes.;Binds to apoB mRNA AU-rich sequences.;May be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.;Is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences.	Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated (By similarity).	NA	NA	PE1	6
+NX_O60507	Protein-tyrosine sulfotransferase 1	370	42188	9.21	1	Golgi apparatus;Golgi apparatus membrane	NA	Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.	N-glycosylated.	Belongs to the protein sulfotransferase family.	Cytosolic sulfonation of small molecules	PE1	7
+NX_O60508	Pre-mRNA-processing factor 17	579	65521	6.62	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Required for pre-mRNA splicing as component of the activated spliceosome.	NA	NA	Spliceosome;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	6
+NX_O60512	Beta-1,4-galactosyltransferase 3	393	43928	9.34	1	Golgi stack membrane;Golgi apparatus;Cytosol	NA	Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.	NA	Belongs to the glycosyltransferase 7 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Other types of O-glycan biosynthesis;Glycosaminoglycan biosynthesis - keratan sulfate;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Keratan sulfate biosynthesis;N-Glycan antennae elongation	PE1	1
+NX_O60513	Beta-1,4-galactosyltransferase 4	344	40041	9.18	1	Golgi stack membrane;Golgi apparatus	NA	Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.	NA	Belongs to the glycosyltransferase 7 family.	Protein modification; protein glycosylation.;Glycosaminoglycan biosynthesis - keratan sulfate;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Keratan sulfate biosynthesis;N-Glycan antennae elongation	PE1	3
+NX_O60516	Eukaryotic translation initiation factor 4E-binding protein 3	100	10873	4.37	0	NA	NA	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.	Phosphorylated.	Belongs to the eIF4E-binding protein family.	NA	PE1	5
+NX_O60518	Ran-binding protein 6	1105	124714	4.88	0	Cytoplasmic vesicle;Cytoplasm;Nucleus	NA	May function in nuclear protein import as nuclear transport receptor.	NA	Belongs to the importin beta family.	NA	PE1	9
+NX_O60519	cAMP-responsive element-binding protein-like 2	120	13784	9.93	0	Nucleoplasm;Cytosol;Mitochondrion;Nucleus	NA	Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.	Phosphorylated by AMPK.	Belongs to the bZIP family. ATF subfamily.	NA	PE1	12
+NX_O60522	Tudor domain-containing protein 6	2096	236517	5.14	0	Cytoplasm	NA	Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression.	Undergoes proteolytic cleavage near the C-terminal by an unknown protease during the transition from meiosis I to meiosis II in primary spermatocytes.	NA	PIWI-interacting RNA (piRNA) biogenesis	PE1	6
+NX_O60524	Nuclear export mediator factor NEMF	1076	122954	5.97	0	Nucleoplasm;Cytosol;Nucleus	NA	Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875).	NA	Belongs to the NEMF family.	NA	PE1	14
+NX_O60542	Persephin	156	16600	9.54	0	Secreted	NA	Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.	NA	Belongs to the TGF-beta family. GDNF subfamily.	RAF/MAP kinase cascade;NCAM1 interactions;RET signaling	PE2	19
+NX_O60543	Cell death activator CIDE-A	219	24687	9.34	0	Nucleus;Lipid droplet	NA	Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.	NA	NA	Lipid particle organization	PE1	18
+NX_O60547	GDP-mannose 4,6 dehydratase	372	41950	6.87	0	NA	NA	Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.	NA	Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.	Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.;Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;GDP-fucose biosynthesis	PE1	6
+NX_O60548	Forkhead box protein D2	495	48748	6.76	0	Nucleus	NA	Probable transcription factor involved in embryogenesis and somatogenesis.	NA	NA	NA	PE1	1
+NX_O60551	Glycylpeptide N-tetradecanoyltransferase 2	498	56980	7.23	0	Cytoplasm;Golgi apparatus;Cell membrane;Membrane;Cytosol	NA	Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.	NA	Belongs to the NMT family.	Membrane binding and targetting of GAG proteins;Inactivation, recovery and regulation of the phototransduction cascade	PE1	10
+NX_O60563	Cyclin-T1	726	80685	8.9	0	Nucleoplasm;Nucleus	NA	(Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.;Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).	NA	Belongs to the cyclin family. Cyclin C subfamily.	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;Interactions of Tat with host cellular proteins;RNA polymerase II transcribes snRNA genes;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	12
+NX_O60565	Gremlin-1	184	20697	9.53	0	Secreted	Polyposis syndrome, mixed hereditary 1	Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).	NA	Belongs to the DAN family.	NA	PE1	15
+NX_O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	1050	119545	5.2	0	Cytoplasm;Nucleus;Centrosome;Cytosol;Kinetochore	Mosaic variegated aneuploidy syndrome 1;Premature chromatid separation trait	Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.	Ubiquitinated. Degraded by the proteasome.;Acetylation at Lys-250 regulates its degradation and timing in anaphase entry.;Proteolytically cleaved by caspase-3 in a cell cycle specific manner. The cleavage might be involved in the durability of the cell cycle delay. Caspase-3 cleavage is associated with abrogation of the mitotic checkpoint. The major site of cleavage is at Asp-610.;Autophosphorylated in vitro. Intramolecular autophosphorylation is stimulated by CENPE. Phosphorylated during mitosis and hyperphosphorylated in mitotically arrested cells. Phosphorylation at Ser-670 and Ser-1043 occurs at kinetochores upon mitotic entry with dephosphorylation at the onset of anaphase.;Sumoylated with SUMO2 and SUMO3. The sumoylation mediates the association with CENPE at the kinetochore.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.	Cell cycle;HTLV-I infection;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of mitotic proteins;APC-Cdc20 mediated degradation of Nek2A;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	15
+NX_O60568	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	738	84785	5.69	0	Endoplasmic reticulum membrane;Secreted;Rough endoplasmic reticulum;Extracellular space;Endoplasmic reticulum lumen	Lysyl hydroxylase 3 deficiency	Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:9582318, PubMed:9724729, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:10934207, PubMed:11896059, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). Essential for normal biosynthesis and secretion of type IV collagens (PubMed:18834968) (Probable). Essential for normal formation of basement membranes (By similarity).	NA	NA	Lysine degradation;Other types of O-glycan biosynthesis;Collagen biosynthesis and modifying enzymes	PE1	7
+NX_O60573	Eukaryotic translation initiation factor 4E type 2	245	28362	8.97	0	Cytosol;Mitochondrion	NA	Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).	ISGylation enhances its cap structure-binding activity and translation-inhibition activity.;Ubiquitinated by ARIH1 (PubMed:14623119, PubMed:25624349). The consequences of ubiquitination are however unclear: according to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report ubiquitination leads to its subsequent degradation (PubMed:14623119).	Belongs to the eukaryotic initiation factor 4E family.	RNA transport;mTOR signaling pathway;Insulin signaling pathway;ISG15 antiviral mechanism	PE1	2
+NX_O60575	Serine protease inhibitor Kazal-type 4	86	9454	7.57	0	Golgi apparatus;Nucleoplasm;Secreted;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	9
+NX_O60583	Cyclin-T2	730	81029	9.04	0	Cell membrane;Nucleoplasm;Cytosol;Perinuclear region;Nucleus	NA	(Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters.;Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity).	NA	Belongs to the cyclin family. Cyclin C subfamily.	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;RNA Polymerase II Pre-transcription Events;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;RNA polymerase II transcribes snRNA genes;TP53 Regulates Transcription of DNA Repair Genes	PE1	2
+NX_O60602	Toll-like receptor 5	858	97834	6.21	1	Golgi apparatus;Nucleoplasm;Cytosol;Cell membrane	Systemic lupus erythematosus 1	Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).	Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.;Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.	Belongs to the Toll-like receptor family.	Toll-like receptor signaling pathway;Pathogenic Escherichia coli infection;Salmonella infection;Legionellosis;MyD88 deficiency (TLR5);IRAK4 deficiency (TLR5);MyD88 cascade initiated on plasma membrane;Toll Like Receptor 5 (TLR5) Cascade	PE1	1
+NX_O60603	Toll-like receptor 2	784	89838	6.17	1	Mitochondrion;Phagosome membrane;Membrane;Nucleoplasm;Membrane raft	NA	Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity).	Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation (PubMed:27805901). Deubiquitinated by USP2 (By similarity).;Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.	Belongs to the Toll-like receptor family.	Phagosome;Toll-like receptor signaling pathway;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);Malaria;Toxoplasmosis;Amoebiasis;Tuberculosis;Measles;Herpes simplex infection;Rheumatoid arthritis;ER-Phagosome pathway;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);Toll Like Receptor TLR1:TLR2 Cascade;Beta defensins;Toll Like Receptor TLR6:TLR2 Cascade;Regulation of TLR by endogenous ligand;Neutrophil degranulation	PE1	4
+NX_O60609	GDNF family receptor alpha-3	400	44511	8.06	0	Cytosol;Cell membrane	NA	Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.	N-glycosylated.	Belongs to the GDNFR family.	RAF/MAP kinase cascade;RET signaling	PE1	5
+NX_O60610	Protein diaphanous homolog 1	1272	141347	5.31	0	Cytoplasm;Cell membrane;Centrosome;Ruffle membrane;Spindle;Nucleus;Cytoskeleton	Seizures, cortical blindness, and microcephaly syndrome;Deafness, autosomal dominant, 1	Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity).	Phosphorylation at Thr-768 is stimulated by cAMP and regulates stability, complex formation and mitochondrial movement.	Belongs to the formin homology family. Diaphanous subfamily.	Focal adhesion;Regulation of actin cytoskeleton;Shigellosis;RHO GTPases Activate Formins;ERBB2 Regulates Cell Motility;Neutrophil degranulation	PE1	5
+NX_O60613	Selenoprotein F	165	18092	4.96	0	Endoplasmic reticulum;Cytosol;Endoplasmic reticulum lumen;Nucleolus	NA	May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum (PubMed:24415556). May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (PubMed:24415556).	The N-terminus is blocked.	Belongs to the selenoprotein M/F family.	NA	PE1	1
+NX_O60635	Tetraspanin-1	241	26301	5.12	4	Cytoplasmic vesicle;Nucleoplasm;Lysosome membrane	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	1
+NX_O60636	Tetraspanin-2	221	24148	7.98	4	Membrane;Nucleoplasm	NA	May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	1
+NX_O60637	Tetraspanin-3	253	28018	5.52	4	Membrane;Golgi apparatus;Nucleoplasm	NA	Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	15
+NX_O60641	Clathrin coat assembly protein AP180	907	92502	4.69	0	Coated pit;Cytosol;Centrosome;Cell membrane	NA	Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).	Thr-310 can be modified by the addition of N-acetylglucosamine which can be further phosphorylated. There is no evidence for direct Thr-310 phosphorylation (By similarity).;SNAP91 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the PICALM/SNAP91 family.	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	6
+NX_O60645	Exocyst complex component 3	745	85567	5.93	0	Cytoplasm;Golgi apparatus;Mitochondrion;Growth cone;Nucleoplasm;Neuron projection;Perinuclear region;Midbody	NA	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	NA	Belongs to the SEC6 family.	Tight junction;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium	PE1	5
+NX_O60656	UDP-glucuronosyltransferase 1-9	530	59941	8.08	1	Endoplasmic reticulum membrane;Microsome	NA	Lacks transferase activity but acts as a negative regulator of isoform 1.;UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;PPARA activates gene expression;Glucuronidation	PE1	2
+NX_O60658	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	829	93304	5.75	0	Golgi apparatus	NA	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).	Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity.	Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.;Purine metabolism;G alpha (s) signalling events	PE1	15
+NX_O60662	Kelch-like protein 41	606	68037	5.14	0	Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Nucleoplasm;Pseudopodium;Sarcoplasmic reticulum membrane;Ruffle;Cytosol;M line;Cytoskeleton	Nemaline myopathy 9	Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.	Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination.	NA	Antigen processing: Ubiquitination & Proteasome degradation;Neddylation	PE1	2
+NX_O60663	LIM homeobox transcription factor 1-beta	402	44917	6.22	0	Nucleoplasm;Nucleus	Nail-patella syndrome	Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.	NA	NA	NA	PE1	9
+NX_O60664	Perilipin-3	434	47075	5.3	0	Cytoplasm;Endosome membrane;Lipid droplet	NA	Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.	NA	Belongs to the perilipin family.	Triglyceride catabolism;Retrograde transport at the Trans-Golgi-Network;Chaperone Mediated Autophagy;Lipophagy;Microautophagy	PE1	19
+NX_O60667	Fas apoptotic inhibitory molecule 3	390	43146	9.78	1	Focal adhesion;Secreted;Membrane;Nucleoplasm;Cytosol	NA	May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.	NA	NA	NA	PE1	1
+NX_O60669	Monocarboxylate transporter 2	478	52200	9.37	12	Nucleoplasm;Cell membrane	NA	Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	Proton-coupled monocarboxylate transport	PE1	12
+NX_O60671	Cell cycle checkpoint protein RAD1	282	31827	4.73	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799).;Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603).	NA	Belongs to the rad1 family.	Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	5
+NX_O60673	DNA polymerase zeta catalytic subunit	3130	352776	8.72	0	Nucleoplasm;Nucleus	NA	Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.	NA	Belongs to the DNA polymerase type-B family.	Metabolic pathways;Fanconi anemia pathway;Translesion synthesis by POLI;Translesion synthesis by REV1;Translesion synthesis by POLK	PE1	6
+NX_O60674	Tyrosine-protein kinase JAK2	1132	130674	6.82	0	Cytoplasm;Cell membrane;Endomembrane system;Focal adhesion;Nucleoplasm;Nucleus	Polycythemia vera;Budd-Chiari syndrome;Thrombocythemia 3;Myelofibrosis;Leukemia, acute myelogenous	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980).	Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813 (By similarity). Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity (By similarity). Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity (By similarity). Also phosphorylated by TEC (By similarity). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558, PubMed:7673114). Phosphorylated on tyrosine residues in response to a signaling cascade that is activated by increased cellular retinol (PubMed:21368206).;JAK2 is phosphorylated by TEC (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.	Chemokine signaling pathway;Jak-STAT signaling pathway;Cholinergic synapse;Adipocytokine signaling pathway;Leishmaniasis;Toxoplasmosis;Tuberculosis;Measles;Influenza A;Herpes simplex infection;RAF/MAP kinase cascade;RMTs methylate histone arginines;Factors involved in megakaryocyte development and platelet production;Interferon gamma signaling;Interleukin receptor SHC signaling;RAF activation;Prolactin receptor signaling;Growth hormone receptor signaling;Signaling by SCF-KIT;Interleukin-3, Interleukin-5 and GM-CSF signaling;Cyclin D associated events in G1;MAPK3 (ERK1) activation;Regulation of IFNG signaling;Interleukin-6 signaling;Signaling by Leptin;MAPK1 (ERK2) activation;Interleukin-20 family signaling;IL-6-type cytokine receptor ligand interactions;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interleukin-4 and Interleukin-13 signaling;Interleukin-35 Signalling;Interleukin-12 signaling;Interleukin-23 signaling;Interleukin-27 signaling;Erythropoietin activates RAS;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Signaling by Erythropoietin;Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5	PE1	9
+NX_O60675	Transcription factor MafK	156	17523	10.1	0	Nucleoplasm;Nucleus	NA	Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9150357, PubMed:8932385). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357).	NA	Belongs to the bZIP family. Maf subfamily.	Factors involved in megakaryocyte development and platelet production	PE1	7
+NX_O60676	Cystatin-8	142	16275	9.05	0	Secreted	NA	Performs a specialized role during sperm development and maturation.	NA	Belongs to the cystatin family.	NA	PE1	20
+NX_O60678	Protein arginine N-methyltransferase 3	531	59903	5.18	0	Cytoplasm	NA	Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	RMTs methylate histone arginines;Protein methylation	PE1	11
+NX_O60682	Musculin	206	22068	9.23	0	Nucleoplasm;Nucleus	NA	Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.	NA	NA	NA	PE1	8
+NX_O60683	Peroxisome biogenesis factor 10	326	37069	10.03	0	Peroxisome membrane;Nucleoplasm	Peroxisome biogenesis disorder complementation group 7;Peroxisome biogenesis disorder 6B;Peroxisome biogenesis disorder 6A	Somewhat implicated in the biogenesis of peroxisomes.	NA	Belongs to the pex2/pex10/pex12 family.	Peroxisome;E3 ubiquitin ligases ubiquitinate target proteins;Peroxisomal protein import	PE1	1
+NX_O60684	Importin subunit alpha-7	536	60030	4.89	0	Nucleoplasm;Cytosol	NA	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.	NA	Belongs to the importin alpha family.	NA	PE1	1
+NX_O60687	Sushi repeat-containing protein SRPX2	465	52972	7.05	0	Cell surface;Cytoplasm;Secreted;Synapse	Rolandic epilepsy with speech dyspraxia and mental retardation X-linked	Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.	Contains chondroitin sulfate chains.	NA	NA	PE1	X
+NX_O60688	Protein yippee-like 1	119	13575	8.21	0	Nucleus	NA	May play a role in epithelioid conversion of fibroblasts.	NA	Belongs to the yippee family.	NA	PE2	22
+NX_O60701	UDP-glucose 6-dehydrogenase	494	55024	6.73	0	Nucleoplasm	NA	Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity).	NA	Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.;Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Formation of the active cofactor, UDP-glucuronate	PE1	4
+NX_O60704	Protein-tyrosine sulfotransferase 2	377	41912	9.22	1	Endoplasmic reticulum;Golgi apparatus membrane	NA	Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.	N-glycosylated.	Belongs to the protein sulfotransferase family.	Cytosolic sulfonation of small molecules	PE1	22
+NX_O60706	ATP-binding cassette sub-family C member 9	1549	174223	7.05	15	Membrane;Nucleoplasm;Cytosol	Hypertrichotic osteochondrodysplasia;Cardiomyopathy, dilated 1O;Atrial fibrillation, familial, 12	Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.	NA	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.	ABC transporters;ABC-family proteins mediated transport;ATP sensitive Potassium channels;Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia;Ion homeostasis	PE1	12
+NX_O60711	Leupaxin	386	43332	5.62	0	Cytoplasm;Nucleus speckle;Cell membrane;Podosome;Focal adhesion;Cytosol;Perinuclear region;Nucleus	NA	Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.	Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72.	Belongs to the paxillin family.	NA	PE1	11
+NX_O60716	Catenin delta-1	968	108170	5.86	0	Cytoplasm;Nucleus;Cell membrane	Blepharocheilodontic syndrome 2	Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.	Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ.	Belongs to the beta-catenin family.	Adherens junction;Leukocyte transendothelial migration;VEGFR2 mediated vascular permeability;Adherens junctions interactions;InlA-mediated entry of Listeria monocytogenes into host cells	PE1	11
+NX_O60721	Sodium/potassium/calcium exchanger 1	1099	121374	4.9	11	Membrane;Cytoskeleton	Night blindness, congenital stationary, 1D	Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).	The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration.	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.	Phototransduction;Activation of the phototransduction cascade;Sodium/Calcium exchangers;Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)	PE1	15
+NX_O60725	Protein-S-isoprenylcysteine O-methyltransferase	284	31938	8.13	8	Endoplasmic reticulum membrane	NA	Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.	NA	Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.	Gamma carboxylation, hypusine formation and arylsulfatase activation	PE1	1
+NX_O60729	Dual specificity protein phosphatase CDC14B	498	56802	9.19	0	Nucleoplasm;Nucleolus	NA	Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.	Cell cycle;MAPK6/MAPK4 signaling	PE1	9
+NX_O60732	Melanoma-associated antigen C1	1142	123643	4.23	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	X
+NX_O60733	85/88 kDa calcium-independent phospholipase A2	806	89903	6.86	0	Membrane;Cytoplasm;Cytosol;Centriolar satellite	Neurodegeneration with brain iron accumulation 2B;Parkinson disease 14;Neurodegeneration with brain iron accumulation 2A	Which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.;Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.	NA	NA	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Acyl chain remodelling of PC;Acyl chain remodelling of PE;Role of phospholipids in phagocytosis;Acyl chain remodeling of CL;COPI-independent Golgi-to-ER retrograde traffic	PE1	22
+NX_O60739	Eukaryotic translation initiation factor 1b	113	12824	6.82	0	NA	NA	Probably involved in translation.	NA	Belongs to the SUI1 family.	RNA transport	PE1	3
+NX_O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	890	98796	8.63	6	Cell membrane	Epileptic encephalopathy, early infantile, 24	Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.	NA	Belongs to the potassium channel HCN family.	HCN channels	PE1	5
+NX_O60749	Sorting nexin-2	519	58471	5.04	0	Early endosome membrane;Lamellipodium;Endosome;Lysosome	NA	Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901).	NA	Belongs to the sorting nexin family.	Golgi Associated Vesicle Biogenesis	PE1	5
+NX_O60755	Galanin receptor type 3	368	39573	10.23	7	Cell membrane	NA	Receptor for the hormone galanin (PubMed:25691535). Receptor for the hormone spexin-1 (PubMed:24517231).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	22
+NX_O60756	Putative protein BCE-1	84	9784	10.67	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_O60759	Cytohesin-interacting protein	359	40010	6.55	0	Nucleoplasm;Cytosol;Early endosome;Cytoplasm	NA	By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.	NA	NA	NA	PE1	2
+NX_O60760	Hematopoietic prostaglandin D synthase	199	23344	5.54	0	Nucleoplasm;Cytoplasm;Cytosol;Cytoplasmic vesicle	NA	Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.	NA	Belongs to the GST superfamily. Sigma family.	Arachidonic acid metabolism;Metabolic pathways;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Glutathione conjugation	PE1	4
+NX_O60762	Dolichol-phosphate mannosyltransferase subunit 1	260	29634	9.57	0	Endoplasmic reticulum	Congenital disorder of glycosylation 1E	Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.	NA	Belongs to the glycosyltransferase 2 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Synthesis of dolichyl-phosphate mannose;Defective DPM2 causes DPM2-CDG (CDG-1u);Defective DPM1 causes DPM1-CDG (CDG-1e);Defective DPM3 causes DPM3-CDG (CDG-1o)	PE1	20
+NX_O60763	General vesicular transport factor p115	962	107895	4.85	0	Golgi apparatus;Cytosol;Nucleolus;Golgi apparatus membrane	NA	General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.	Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation.	Belongs to the VDP/USO1/EDE1 family.	Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport	PE1	4
+NX_O60765	Zinc finger protein 354A	605	69237	9.65	0	Nucleoplasm;Nucleolus;Nucleus;Cytosol	NA	NA	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	5
+NX_O60774	Putative dimethylaniline monooxygenase [N-oxide-forming] 6	539	61291	5.99	1	Microsome membrane;Endoplasmic reticulum membrane	NA	It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full-length transcripts.	NA	Belongs to the FMO family.	NA	PE5	1
+NX_O60779	Thiamine transporter 1	497	55400	6.35	12	Cytosol;Cell membrane	Thiamine-responsive megaloblastic anemia syndrome	High-affinity transporter for the intake of thiamine.	NA	Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.	Vitamin digestion and absorption;Vitamin B1 (thiamin) metabolism	PE1	1
+NX_O60783	28S ribosomal protein S14, mitochondrial	128	15139	11.42	0	Mitochondrion;Nucleus membrane	Combined oxidative phosphorylation deficiency 38	NA	NA	Belongs to the universal ribosomal protein uS14 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	1
+NX_O60784	Target of Myb protein 1	492	53818	4.59	0	Cytoplasm;Cell membrane;Centriolar satellite;Membrane;Cytosol	NA	May be involved in intracellular trafficking. Probable association with membranes.	NA	Belongs to the TOM1 family.	Neutrophil degranulation	PE1	22
+NX_O60806	T-box transcription factor TBX19	448	48238	6.66	0	Nucleus speckle;Nucleus	ACTH deficiency, isolated	Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters.	NA	NA	NA	PE1	1
+NX_O60809	PRAME family member 10	474	55211	8.71	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_O60810	PRAME family member 4	478	55439	8.69	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_O60811	PRAME family member 2	474	54872	8.12	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_O60812	Heterogeneous nuclear ribonucleoprotein C-like 1	293	32142	4.93	0	Nucleus	NA	May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.	NA	Belongs to the RRM HNRPC family. RALY subfamily.	NA	PE1	1
+NX_O60813	PRAME family member 11	478	55344	8.83	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_O60814	Histone H2B type 1-K	126	13890	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.;Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.	GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).;Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_O60825	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2	505	58477	8.61	0	Nucleoplasm	NA	Synthesis and degradation of fructose 2,6-bisphosphate.	Phosphorylation by AMPK stimulates activity.	In the C-terminal section; belongs to the phosphoglycerate mutase family.	Fructose and mannose metabolism;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	1
+NX_O60826	Coiled-coil domain-containing protein 22	627	70756	6.3	0	Nucleoplasm;Cytosol;Endosome	Ritscher-Schinzel syndrome 2	(Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.;Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:28892079, PubMed:25355947). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947).	NA	Belongs to the CCDC22 family.	Neddylation	PE1	X
+NX_O60828	Polyglutamine-binding protein 1	265	30472	5.92	0	Cytoplasmic granule;Nucleus speckle;Nucleus	Renpenning syndrome 1	Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:23512658, PubMed:20410308). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating to the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437).	NA	NA	mRNA Splicing - Major Pathway	PE1	X
+NX_O60829	P antigen family member 4	102	11153	4.71	0	Golgi apparatus;Cytoplasm;Mitochondrion;Cytoplasmic vesicle;Nucleus	NA	Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN (PubMed:24263171, PubMed:28289210). Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway (PubMed:21357425, PubMed:25374899, PubMed:30658679).	HIPK1-mediated phosphorylation at Thr-51 leads to the compaction of its intrinsically disordered conformation and is critical for its ability to potentiate the transcriptional activator activity of JUN inspite of a reduced interaction with JUN (PubMed:24559171, PubMed:26242913). CLK2-mediated phosphorylation at multiple Ser and Thr residues attenuates its ability to potentiate JUN transcriptional activator activity (PubMed:28289210).	Belongs to the GAGE family.	NA	PE1	X
+NX_O60830	Mitochondrial import inner membrane translocase subunit Tim17-B	172	18273	9.21	3	Mitochondrion inner membrane;Mitochondrion;Cytoskeleton	NA	Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Forms one disulfide bond.	Belongs to the Tim17/Tim22/Tim23 family.	Mitochondrial protein import	PE1	X
+NX_O60831	PRA1 family protein 2	178	19258	9.41	4	Endoplasmic reticulum;Cytoplasmic vesicle;Endosome membrane	NA	May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis.	NA	Belongs to the PRA1 family.	NA	PE1	X
+NX_O60832	H/ACA ribonucleoprotein complex subunit DKC1	514	57674	9.46	0	Cajal body;Cytoplasm;Nucleolus;Nucleoplasm;Nucleus	Hoyeraal-Hreidarsson syndrome;Dyskeratosis congenita, X-linked	Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534).;Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression.	NA	Belongs to the pseudouridine synthase TruB family.	Ribosome biogenesis in eukaryotes;Telomere Extension By Telomerase;rRNA modification in the nucleus and cytosol	PE1	X
+NX_O60840	Voltage-dependent L-type calcium channel subunit alpha-1F	1977	220678	5.76	24	Membrane	Night blindness, congenital stationary, 2A;Cone-rod dystrophy, X-linked 3;Aaland island eye disease	Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations.;Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization.;Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exhibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations.	NA	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1F subfamily.	MAPK signaling pathway;Calcium signaling pathway;Cardiac muscle contraction;Vascular smooth muscle contraction;Cholinergic synapse;GABAergic synapse;GnRH signaling pathway;Alzheimer's disease;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	X
+NX_O60841	Eukaryotic translation initiation factor 5B	1220	138827	5.39	0	Cytoplasm;Cytosol;Cell membrane	NA	Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.	RNA transport;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	2
+NX_O60844	Zymogen granule membrane protein 16	167	18147	9.43	0	Golgi apparatus lumen;Extracellular matrix;Cytoplasmic vesicle lumen	NA	May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.	NA	Belongs to the jacalin lectin family.	NA	PE1	16
+NX_O60858	E3 ubiquitin-protein ligase TRIM13	407	46988	5.75	1	Endoplasmic reticulum membrane	NA	Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor (PubMed:22178386). Plays also a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809). Participates as well in T-cell receptor-mediated NF-kappa-B activation (PubMed:25088585). In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B (PubMed:25152375).	Auto-ubiquitinated; requires the RING-type zinc finger. Auto-polyubiquitination leads to proteasomal degradation.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;ER Quality Control Compartment (ERQC)	PE1	13
+NX_O60861	Growth arrest-specific protein 7	476	54371	6.91	0	Cytoplasm;Focal adhesion;Cell membrane;Cytoskeleton	NA	May play a role in promoting maturation and morphological differentiation of cerebellar neurons.	NA	NA	NA	PE1	17
+NX_O60869	Endothelial differentiation-related factor 1	148	16369	9.95	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.	Phosphorylated (by PKA and PKC).	NA	NA	PE1	9
+NX_O60870	DNA/RNA-binding protein KIN17	393	45374	9.07	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.	NA	Belongs to the KIN17 family.	Protein methylation	PE1	10
+NX_O60879	Protein diaphanous homolog 2	1101	125569	6.2	0	Early endosome;Nucleolus;Endoplasmic reticulum;Cytoplasmic vesicle;Cytosol	Premature ovarian failure 2A	Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.	NA	Belongs to the formin homology family. Diaphanous subfamily.	Regulation of actin cytoskeleton;RHO GTPases Activate Formins	PE1	X
+NX_O60880	SH2 domain-containing protein 1A	128	14187	8.74	0	Cytoplasm	Lymphoproliferative syndrome, X-linked, 1	Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.	NA	NA	Natural killer cell mediated cytotoxicity;Measles;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	X
+NX_O60882	Matrix metalloproteinase-20	483	54387	8.92	0	Extracellular matrix	Amelogenesis imperfecta, hypomaturation type, 2A2	Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site.	Autoactivates at least at the 107-Asn-|-Tyr-108 site.	Belongs to the peptidase M10A family.	Degradation of the extracellular matrix;Collagen degradation;Assembly of collagen fibrils and other multimeric structures	PE1	11
+NX_O60883	G-protein coupled receptor 37-like 1	481	52771	7.37	7	Cilium membrane;Cell membrane	NA	G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).	Ubiquitinated.;Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity.;O-glycosylated.	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	1
+NX_O60884	DnaJ homolog subfamily A member 2	412	45746	6.06	0	Membrane;Cytosol;Nucleolus;Cytoskeleton	NA	Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).	NA	NA	Protein processing in endoplasmic reticulum;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	16
+NX_O60885	Bromodomain-containing protein 4	1362	152219	9.23	0	Nucleoplasm;Nucleus;Chromosome	NA	Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AFX/H2A.x phosphorylation.;Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504).	Phosphorylation by CK2 disrupt the intramolecular binding between the bromo domain 2 and the NPS region and promotes binding between the NPS and the BID regions, leading to activate the protein and promote binding to acetylated histones. In absence of phosphorylation, BRD4 does not localize to p53/TP53 target gene promoters, phosphorylation promoting recruitment to p53/TP53 target promoters.;BRD4 is phosphorylated by CDK7	NA	NA	PE1	19
+NX_O60888	Protein CutA	179	19116	5.42	0	Focal adhesion;Cell membrane	NA	May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE).	O-glycosylated.	Belongs to the CutA family.	NA	PE1	6
+NX_O60890	Oligophrenin-1	802	91641	8.08	0	Cytoplasm;Dendritic spine;Cell membrane;Postsynapse;Nucleoplasm;Presynapse;Axon;Dendrite	Mental retardation, X-linked, syndromic, OPHN1-related	Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity).	NA	NA	Rho GTPase cycle	PE1	X
+NX_O60894	Receptor activity-modifying protein 1	148	16988	8.55	1	Membrane;Nucleoplasm;Nucleus membrane	NA	Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.	NA	Belongs to the RAMP family.	Vascular smooth muscle contraction;G alpha (s) signalling events;Calcitonin-like ligand receptors	PE1	2
+NX_O60895	Receptor activity-modifying protein 2	175	19608	5.49	1	Membrane;Cytoplasmic vesicle	NA	Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.	NA	Belongs to the RAMP family.	Vascular smooth muscle contraction;G alpha (s) signalling events;Calcitonin-like ligand receptors	PE1	17
+NX_O60896	Receptor activity-modifying protein 3	148	16518	5.32	1	Membrane;Cell membrane	NA	Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.	NA	Belongs to the RAMP family.	Vascular smooth muscle contraction;G alpha (s) signalling events;Calcitonin-like ligand receptors	PE1	7
+NX_O60902	Short stature homeobox protein 2	331	34953	8.99	0	Nucleus	NA	May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.	NA	Belongs to the paired homeobox family. Bicoid subfamily.	NA	PE1	3
+NX_O60906	Sphingomyelin phosphodiesterase 2	423	47646	6.49	2	Membrane;Cytoplasmic vesicle;Cell junction;Cell membrane	NA	Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.	NA	Belongs to the neutral sphingomyelinase family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Glycosphingolipid metabolism;Ceramide signalling;TNFR1-mediated ceramide production	PE1	6
+NX_O60907	F-box-like/WD repeat-containing protein TBL1X	577	62496	6.08	0	Nucleoplasm;Nucleolus;Nucleus	NA	F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272).	NA	Belongs to the WD repeat EBI family.	Wnt signaling pathway;PPARA activates gene expression;HDACs deacetylate histones;Notch-HLH transcription pathway;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Regulation of MECP2 expression and activity;Loss of MECP2 binding ability to the NCoR/SMRT complex	PE1	X
+NX_O60909	Beta-1,4-galactosyltransferase 2	372	41972	9.47	1	Golgi apparatus;Cytoplasmic vesicle;Golgi stack membrane	NA	Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose.	NA	Belongs to the glycosyltransferase 7 family.	Protein modification; protein glycosylation.;Galactose metabolism;N-Glycan biosynthesis;Other types of O-glycan biosynthesis;Glycosaminoglycan biosynthesis - keratan sulfate;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Keratan sulfate biosynthesis;N-Glycan antennae elongation	PE1	1
+NX_O60911	Cathepsin L2	334	37329	8.98	0	Cell membrane;Nucleolus;Nucleoplasm;Lysosome;Cytosol	NA	Cysteine protease. May have an important role in corneal physiology.	NA	Belongs to the peptidase C1 family.	Lysosome;Degradation of the extracellular matrix;MHC class II antigen presentation;Endosomal/Vacuolar pathway;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;Activation of Matrix Metalloproteinases;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	PE1	9
+NX_O60921	Checkpoint protein HUS1	280	31691	6.37	0	Cytosol;Nucleus	NA	Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.	NA	Belongs to the HUS1 family.	Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	7
+NX_O60925	Prefoldin subunit 1	122	14210	6.32	0	Cytoplasm;Cytosol;Nucleolus;Cell membrane	NA	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.	NA	Belongs to the prefoldin subunit beta family.	Prefoldin mediated transfer of substrate to CCT/TriC	PE1	5
+NX_O60927	E3 ubiquitin-protein ligase PPP1R11	126	13952	6.52	0	Cytoplasmic vesicle	NA	Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442).	Auto-ubiquitinated.	NA	Protein modification; protein ubiquitination.	PE1	6
+NX_O60928	Inward rectifier potassium channel 13	360	40530	5.84	2	Membrane	Leber congenital amaurosis 16;Snowflake vitreoretinal degeneration	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.	Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them.	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ13 subfamily.	Protein digestion and absorption	PE1	2
+NX_O60930	Ribonuclease H1	286	32064	9.28	0	Cytoplasm	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2	Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224).	NA	Belongs to the RNase H family.	DNA replication	PE1	2
+NX_O60931	Cystinosin	367	41738	9.12	7	Cell membrane;Lysosome membrane;Melanosome;Cytoplasmic vesicle;Cytoskeleton	Cystinosis, adult, non-nephropathic type;Cystinosis, nephropathic type;Cystinosis, late-onset juvenile or adolescent nephropathic type	Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.	NA	Belongs to the cystinosin family.	Lysosome;Miscellaneous transport and binding events;Transport of inorganic cations/anions and amino acids/oligopeptides	PE1	17
+NX_O60934	Nibrin	754	84959	6.5	0	Golgi apparatus;Chromosome;Nucleoplasm;Telomere;PML body;Nucleus	Breast cancer;Aplastic anemia;Nijmegen breakage syndrome	Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.	Phosphorylated by ATM in response of ionizing radiation, and such phosphorylation is responsible intra-S phase checkpoint control and telomere maintenance.	NA	Homologous recombination;DNA Damage/Telomere Stress Induced Senescence;Meiotic recombination;G2/M DNA damage checkpoint;Sensing of DNA Double Strand Breaks;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Single Strand Annealing (SSA);HDR through MMEJ (alt-NHEJ);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Nonhomologous End-Joining (NHEJ);Regulation of TP53 Activity through Phosphorylation	PE1	8
+NX_O60936	Nucleolar protein 3	208	22629	4.11	0	Cytoplasm;Mitochondrion;Nucleolus;Membrane;Nucleoplasm;Sarcoplasmic reticulum;Cytosol	Myoclonus, familial, 1	May be involved in RNA splicing.;Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity).	Polyubiquitinated by MDM2; promoting proteasomal-dependent degradation in response to apoptotic stimuli.;Phosphorylation at Thr-149 is required for its antiapoptotic effect by blocking death-inducing signaling complex death-inducing signaling complex (DISC) activity through the control of interaction with CASP8. Phosphorylation at Thr-149 results in translocation to mitochondria and this translocation enables the binding to CASP8. Dephosphorylated at Thr-149 by calcineurin; doesn't inhibit the association between FADD and CASP8 and the consequent apoptosis.	NA	NA	PE1	16
+NX_O60938	Keratocan	352	40509	7.11	0	Extracellular matrix	Cornea plana 2, autosomal recessive	May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	Binds keratan sulfate chains.	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Keratan sulfate biosynthesis;Defective CHST6 causes MCDC1;Keratan sulfate degradation;Defective B4GALT1 causes B4GALT1-CDG (CDG-2d);Defective ST3GAL3 causes MCT12 and EIEE15	PE1	12
+NX_O60939	Sodium channel subunit beta-2	215	24326	5.98	1	Membrane	Atrial fibrillation, familial, 14	Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).	NA	Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	11
+NX_O60941	Dystrobrevin beta	627	71356	8.11	0	Cytoplasm;Mitochondrion	NA	NA	NA	Belongs to the dystrophin family. Dystrobrevin subfamily.	NA	PE1	2
+NX_O60942	mRNA-capping enzyme	597	68557	8.43	0	Nucleoplasm;Nucleus	NA	Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.	NA	In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.;In the C-terminal section; belongs to the eukaryotic GTase family.	mRNA surveillance pathway;mRNA Capping;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;RNA Pol II CTD phosphorylation and interaction with CE	PE1	6
+NX_O71037	Endogenous retrovirus group K member 19 Env polyprotein	699	79252	9.2	1	Virion;Cell membrane	NA	SU mediates receptor recognition.;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.;TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.	NA	PE1	19
+NX_O75015	Low affinity immunoglobulin gamma Fc region receptor III-B	233	26216	6.22	0	Secreted;Cell membrane	NA	Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.	The soluble form is produced by a proteolytic cleavage.;Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.	NA	Phagosome;Osteoclast differentiation;Natural killer cell mediated cytotoxicity;Leishmaniasis;Staphylococcus aureus infection;Tuberculosis;Systemic lupus erythematosus;Neutrophil degranulation;Post-translational modification: synthesis of GPI-anchored proteins	PE1	1
+NX_O75019	Leukocyte immunoglobulin-like receptor subfamily A member 1	489	53275	7.97	1	Membrane	NA	May act as receptor for class I MHC antigens.	NA	NA	Osteoclast differentiation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_O75022	Leukocyte immunoglobulin-like receptor subfamily B member 3	631	69386	6.45	1	Cell membrane	NA	May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).	Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.;LILRB3 is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	NA	Osteoclast differentiation;B cell receptor signaling pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Neutrophil degranulation	PE1	19
+NX_O75023	Leukocyte immunoglobulin-like receptor subfamily B member 5	590	64126	6.92	1	Membrane	NA	May act as receptor for class I MHC antigens.	NA	NA	Osteoclast differentiation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_O75027	ATP-binding cassette sub-family B member 7, mitochondrial	752	82641	9.37	6	Mitochondrion inner membrane;Mitochondrion	Anemia, sideroblastic, spinocerebellar ataxia	Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.	NA	Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.	ABC transporters;Cytosolic iron-sulfur cluster assembly;Mitochondrial ABC transporters	PE1	X
+NX_O75030	Microphthalmia-associated transcription factor	526	58795	5.93	0	Nucleus	Waardenburg syndrome 2, with ocular albinism, autosomal recessive;Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness;Waardenburg syndrome 2A;Tietz albinism-deafness syndrome;Melanoma, cutaneous malignant 8	Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.	Phosphorylation at Ser-405 significantly enhances the ability to bind the tyrosinase promoter. Phosphorylated at Ser-180 and Ser-516 following KIT signaling, trigerring a short live activation: Phosphorylation at Ser-180 and Ser-516 by MAPK and RPS6KA1, respectively, activate the transcription factor activity but also promote ubiquitination and subsequent degradation by the proteasome.;Ubiquitinated following phosphorylation at Ser-180, leading to subsequent degradation by the proteasome. Deubiquitinated by USP13, preventing its degradation.	Belongs to the MiT/TFE family.	Osteoclast differentiation;Melanogenesis;Pathways in cancer;Melanoma;SUMOylation of transcription factors	PE1	3
+NX_O75031	Heat shock factor 2-binding protein	334	37645	5.43	0	Nucleoplasm;Cytosol;Cytoplasm	NA	May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).	Sumoylated by UBE2I in response to MEKK1-mediated stimuli.	NA	NA	PE1	21
+NX_O75037	Kinesin-like protein KIF21B	1637	182662	6.7	0	Axon;Cell membrane;Growth cone;Cytoplasmic vesicle;Cytosol;Spindle;Dendrite;Cytoskeleton	NA	Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	1
+NX_O75038	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	1416	154668	8.04	0	Cytoplasm;Cell membrane	NA	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).	NA	NA	Synthesis of IP3 and IP4 in the cytosol	PE1	1
+NX_O75044	SLIT-ROBO Rho GTPase-activating protein 2	1071	120871	6.25	0	Cytoplasm;Dendritic spine;Cell membrane;Postsynaptic cell membrane;Lamellipodium;Phagosome;Postsynaptic density;Nucleus	NA	RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.	Methylation at Arg-927 is required for the stimulation of cell migration, dimerization and localization at the plasma membrane protrusions.	NA	Axon guidance;RHO GTPases Activate Formins;Rho GTPase cycle;Inactivation of CDC42 and RAC1	PE1	1
+NX_O75051	Plexin-A2	1894	211104	6.05	1	Cell membrane	NA	Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).	NA	Belongs to the plexin family.	Axon guidance;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Sema3A PAK dependent Axon repulsion;CRMPs in Sema3A signaling;Other semaphorin interactions	PE1	1
+NX_O75052	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	506	56150	5.89	0	Nucleoplasm;Cytoplasmic vesicle	NA	Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).	NA	NA	NA	PE1	1
+NX_O75054	Immunoglobulin superfamily member 3	1194	135196	5.75	1	Membrane;Nucleoplasm;Cytosol	Lacrimal duct defect	NA	NA	NA	NA	PE1	1
+NX_O75056	Syndecan-3	442	45497	4.61	1	Nucleoplasm;Mitochondrion;Cell membrane	NA	Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.	O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules.	Belongs to the syndecan proteoglycan family.	ECM-receptor interaction;Cell adhesion molecules (CAMs);Malaria;Retinoid metabolism and transport;HS-GAG biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Syndecan interactions;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Cell surface interactions at the vascular wall;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	1
+NX_O75061	Putative tyrosine-protein phosphatase auxilin	913	99997	6.82	0	Nucleoplasm;Cytosol;Cell membrane	Parkinson disease 19B, early-onset;Parkinson disease 19A, juvenile-onset	Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).	NA	NA	Endocytosis;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Clathrin-mediated endocytosis	PE1	1
+NX_O75063	Glycosaminoglycan xylosylkinase	409	46432	6.4	1	Golgi apparatus;Nucleoplasm;Golgi apparatus membrane	NA	Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.	NA	Belongs to the FAM20 family.	NA	PE1	1
+NX_O75064	DENN domain-containing protein 4B	1496	163847	6.85	0	Golgi apparatus;Nucleoplasm	NA	Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	1
+NX_O75069	Transmembrane and coiled-coil domains protein 2	709	77449	6.34	2	Endoplasmic reticulum membrane	NA	May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE.	NA	Belongs to the TEX28 family.	NA	PE1	1
+NX_O75071	EF-hand calcium-binding domain-containing protein 14	495	55031	5.98	0	Golgi apparatus;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	1
+NX_O75072	Fukutin	461	53724	8.63	1	Cytoplasm;Nucleus;Golgi apparatus membrane	Cardiomyopathy, dilated 1X;Muscular dystrophy-dystroglycanopathy limb-girdle C4;Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A4;Muscular dystrophy-dystroglycanopathy congenital without mental retardation B4	Catalyzes the transfer of CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:17034757). May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:25279699). Could be involved in brain development (Probable).	NA	Belongs to the LicD transferase family.	Protein modification; protein glycosylation.	PE1	9
+NX_O75074	Low-density lipoprotein receptor-related protein 3	770	82884	5.83	1	Membrane;Coated pit;Lipid droplet	NA	Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.	NA	Belongs to the LDLR family.	NA	PE1	19
+NX_O75077	Disintegrin and metalloproteinase domain-containing protein 23	832	91926	7.85	1	Secreted;Cell membrane	NA	May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.	NA	NA	LGI-ADAM interactions	PE1	2
+NX_O75078	Disintegrin and metalloproteinase domain-containing protein 11	769	83418	6.91	1	Membrane	NA	Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.	The precursor is cleaved by a furin endopeptidase.	NA	LGI-ADAM interactions	PE1	17
+NX_O75081	Protein CBFA2T3	653	71192	8.5	0	Nucleoplasm;Nucleolus;Golgi apparatus membrane	NA	Functions as an A-kinase-anchoring protein (PubMed:11823486).;Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665).	NA	Belongs to the CBFA2T family.	NA	PE1	16
+NX_O75083	WD repeat-containing protein 1	606	66194	6.17	0	Cytoplasm;Cell membrane;Cell junction;Podosome;Cytoskeleton	NA	Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).	NA	Belongs to the WD repeat AIP1 family.	Platelet degranulation	PE1	4
+NX_O75084	Frizzled-7	574	63620	8.12	7	Cytoplasmic vesicle;Cell membrane;Endosome membrane	NA	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.	Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Asymmetric localization of PCP proteins;Class B/2 (Secretin family receptors);PCP/CE pathway	PE1	2
+NX_O75093	Slit homolog 1 protein	1534	167926	6.14	0	Secreted;Cell membrane	NA	Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.	NA	NA	Axon guidance;Netrin-1 signaling;Signaling by ROBO receptors;Regulation of commissural axon pathfinding by SLIT and ROBO;Regulation of expression of SLITs and ROBOs;Regulation of cortical dendrite branching	PE1	10
+NX_O75094	Slit homolog 3 protein	1523	167713	7.99	0	Cell junction;Secreted	NA	May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.	NA	NA	Axon guidance;Netrin-1 signaling;Signaling by ROBO receptors;Regulation of commissural axon pathfinding by SLIT and ROBO	PE1	5
+NX_O75095	Multiple epidermal growth factor-like domains protein 6	1541	161185	5.94	0	Cytoplasm;Secreted;Cytoskeleton	NA	NA	NA	NA	NA	PE1	1
+NX_O75096	Low-density lipoprotein receptor-related protein 4	1905	212045	5.06	1	Nucleoplasm;Mitochondrion;Nucleolus;Cell membrane	Myasthenic syndrome, congenital, 17;Cenani-Lenz syndactyly syndrome;Sclerosteosis 2	Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).	NA	Belongs to the LDLR family.	ECM proteoglycans	PE1	11
+NX_O75106	Retina-specific copper amine oxidase	756	83673	6.54	0	Cytoplasm;Cell membrane	NA	Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina.	Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.	Belongs to the copper/topaquinone oxidase family.	Glycine, serine and threonine metabolism;Tyrosine metabolism;Phenylalanine metabolism;beta-Alanine metabolism;Metabolic pathways;Phase I - Functionalization of compounds	PE1	17
+NX_O75110	Probable phospholipid-transporting ATPase IIA	1047	118583	8.01	10	Early endosome membrane;Recycling endosome;trans-Golgi network membrane	NA	NA	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases	PE1	20
+NX_O75112	LIM domain-binding protein 3	727	77135	8.47	0	Focal adhesion;Nucleoplasm;Pseudopodium;Cytosol;Z line;Perinuclear region;Cytoskeleton	Cardiomyopathy, dilated 1C, with or without left ventricular non-compaction;Left ventricular non-compaction 3;Myopathy, myofibrillar, 4	May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.	NA	NA	NA	PE1	10
+NX_O75113	NEDD4-binding protein 1	896	100379	5.24	0	Nucleolus;PML body	NA	Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity).	Monoubiquitinated by NEDD4. Polyubiquitinated, leading to its degradation by the proteasome. Sumoylated with SUMO1, abrogating polyubiquitination and subsequent degradation. Desumoylated by SENP1, leading to accumulation in PML nuclear bodies (By similarity).	Belongs to the N4BP1 family.	NA	PE1	16
+NX_O75116	Rho-associated protein kinase 2	1388	160900	5.75	0	Cytoplasm;Cell membrane;Centrosome;Cytosol;Nucleus	NA	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.	Cleaved by granzyme B during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.;Phosphorylation at Tyr-722 reduces its binding to RHOA and is crucial for focal adhesion dynamics. Dephosphorylation by PTPN11 stimulates its RHOA binding activity.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Chemokine signaling pathway;Vascular smooth muscle contraction;Wnt signaling pathway;TGF-beta signaling pathway;Axon guidance;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;EPHB-mediated forward signaling;G alpha (12/13) signalling events;VEGFA-VEGFR2 Pathway;EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;RHO GTPases Activate ROCKs	PE1	2
+NX_O75121	Microfibrillar-associated protein 3-like	409	45380	5.13	1	Cytoplasm;Cell membrane;Cell junction;Nucleoplasm;Nucleus	NA	May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.	NA	NA	NA	PE1	4
+NX_O75122	CLIP-associating protein 2	1294	141064	8.62	0	trans-Golgi network;Golgi apparatus;Cell membrane;Centrosome;Ruffle membrane;Cytosol;Spindle;Kinetochore;Cytoskeleton	NA	Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.	Phosphorylated by GSK3B. Phosphorylation reduces MAPRE1 binding (PubMed:26003921). Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella.	Belongs to the CLASP family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Role of ABL in ROBO-SLIT signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	3
+NX_O75123	Zinc finger protein 623	536	61392	8.52	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_O75127	Pentatricopeptide repeat-containing protein 1, mitochondrial	700	78856	8.81	0	Mitochondrion matrix;Mitochondrion	NA	Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs.	NA	Belongs to the PTCD1 family.	NA	PE1	7
+NX_O75128	Protein cordon-bleu	1261	135617	7.66	0	Cytoplasm;Cell membrane;Cell junction;Ruffle;Cytoskeleton	NA	Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles.	NA	NA	NA	PE1	7
+NX_O75129	Astrotactin-2	1339	148243	5.66	2	Clathrin-coated vesicle;Cell cortex;Early endosome;Perikaryon;Membrane;Nucleoplasm;Late endosome;Cytoplasmic vesicle;Cytosol	NA	Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6).	NA	Belongs to the astrotactin family.	NA	PE1	9
+NX_O75131	Copine-3	537	60131	5.6	0	Cytoplasm;Mitochondrion;Cell membrane;Cell junction;Focal adhesion;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).	Phosphorylated on serine and threonine residues (PubMed:11041869).	Belongs to the copine family.	Glycerophospholipid biosynthesis;Neutrophil degranulation	PE1	8
+NX_O75132	Zinc finger BED domain-containing protein 4	1171	130322	6.38	0	Nucleoplasm;Cytoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	22
+NX_O75140	GATOR complex protein DEPDC5	1603	181264	6.27	0	Cytosol;Lysosome membrane;Perinuclear region	Epilepsy, familial focal, with variable foci 1	As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.	Ubiquitinated. Amino acid-induced 'Lys-48'-linked polyubiquitination of DEPDC5 by the BCR(KLHL22) ubiquitin ligase complex leads to DEPDC5 proteasomal degradation and inhibition of the GATOR1 complex (PubMed:29769719). Ubiquitination may occur at multiple lysines (PubMed:29769719).	Belongs to the IML1 family.	NA	PE1	22
+NX_O75143	Autophagy-related protein 13	517	56572	4.98	0	Nucleoplasm;Preautophagosomal structure;Cell membrane;Cytosol	NA	Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.	Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria.;ATG13 is phosphorylated by ULK2	Belongs to the ATG13 family. Metazoan subfamily.	Macroautophagy	PE1	11
+NX_O75144	ICOS ligand	302	33349	5.15	1	Cytosol;Cell membrane	NA	Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).	NA	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Cell adhesion molecules (CAMs);Intestinal immune network for IgA production;Costimulation by the CD28 family	PE1	21
+NX_O75145	Liprin-alpha-3	1194	133496	5.53	0	Cytoplasmic vesicle;Cytoplasm;Nucleolus;Acrosome	NA	May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.	NA	Belongs to the liprin family. Liprin-alpha subfamily.	Acetylcholine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Receptor-type tyrosine-protein phosphatases	PE1	19
+NX_O75146	Huntingtin-interacting protein 1-related protein	1068	119388	6.22	0	Cell membrane;Endomembrane system;Clathrin-coated vesicle membrane;Cytoplasmic vesicle;Cytosol;Perinuclear region	NA	Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.	NA	Belongs to the SLA2 family.	Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis	PE1	12
+NX_O75147	Obscurin-like protein 1	1896	206947	5.42	0	Golgi apparatus;Cytoplasm;Perinuclear region;Centrosome	3M syndrome 2	Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons.	NA	NA	Neddylation	PE1	2
+NX_O75150	E3 ubiquitin-protein ligase BRE1B	1001	113678	5.97	0	Nucleoplasm;Nucleus	NA	Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.	NA	Belongs to the BRE1 family.	Protein modification; protein ubiquitination.;E3 ubiquitin ligases ubiquitinate target proteins	PE1	16
+NX_O75151	Lysine-specific demethylase PHF2	1096	120775	9.25	0	Kinetochore;Nucleoplasm;Nucleolus	NA	Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.	Phosphorylated by PKA on specific serine residues, leading to the formation of an active lysine demethylase complex.	Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.	HDMs demethylate histones	PE1	9
+NX_O75152	Zinc finger CCCH domain-containing protein 11A	810	89131	8.62	0	NA	NA	Involved in nuclear mRNA export; probably mediated by association with the TREX complex.	NA	NA	Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	1
+NX_O75153	Clustered mitochondria protein homolog	1309	146670	5.75	0	Cytoplasm;Cytoplasmic granule;Nucleus;Cytoplasmic vesicle	NA	MRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.	NA	Belongs to the CLU family.	NA	PE1	17
+NX_O75154	Rab11 family-interacting protein 3	756	82440	4.44	0	Cleavage furrow;Centriolar satellite;Centrosome;Recycling endosome membrane;Cytoplasmic vesicle;Midbody;Cytoskeleton	NA	Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).	Phosphorylated at Ser-102 by CDK1 during metaphase, and dephosphorylated as cells enter telophase.	NA	Endocytosis;VxPx cargo-targeting to cilium	PE1	16
+NX_O75155	Cullin-associated NEDD8-dissociated protein 2	1236	135256	5.44	0	Cytosol;Nucleus	NA	Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.	Ubiquitinated and targeted for proteasomal degradation.	Belongs to the CAND family.	NA	PE1	3
+NX_O75157	TSC22 domain family protein 2	780	79228	4.9	0	Cytosol	NA	NA	NA	Belongs to the TSC-22/Dip/Bun family.	NA	PE1	3
+NX_O75159	Suppressor of cytokine signaling 5	536	61246	8.87	0	Nucleoplasm;Cytosol;Cell membrane	NA	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.	Phosphorylated. Phosphorylation is induced by EGF.	NA	Protein modification; protein ubiquitination.;Jak-STAT signaling pathway;Interleukin-4 and Interleukin-13 signaling;Neddylation	PE1	2
+NX_O75161	Nephrocystin-4	1426	157598	8.4	0	Cilium basal body;Nucleoplasm;Tight junction;Centrosome;Cytoplasmic vesicle;Cytosol;Nucleus	Senior-Loken syndrome 4;Nephronophthisis 4	Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462).	NA	Belongs to the NPHP4 family.	Anchoring of the basal body to the plasma membrane;Signaling by Hippo	PE1	1
+NX_O75164	Lysine-specific demethylase 4A	1064	120662	5.61	0	Nucleolus;Nucleus	NA	Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.;Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.	Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited.	Belongs to the JHDM3 histone demethylase family.	HDMs demethylate histones;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	PE1	1
+NX_O75165	DnaJ homolog subfamily C member 13	2243	254415	6.31	0	Endosome membrane;Early endosome;Early endosome membrane;Cytoplasmic vesicle;Cytosol	Parkinson disease	Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499).	NA	NA	Neutrophil degranulation	PE1	3
+NX_O75167	Phosphatase and actin regulator 2	634	69700	8.14	0	Membrane	NA	NA	NA	Belongs to the phosphatase and actin regulator family.	Platelet degranulation	PE1	6
+NX_O75170	Serine/threonine-protein phosphatase 6 regulatory subunit 2	966	104942	4.74	0	Cytoplasmic vesicle;Cytosol;Cytoplasm	NA	Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.	NA	Belongs to the SAPS family.	NA	PE1	22
+NX_O75173	A disintegrin and metalloproteinase with thrombospondin motifs 4	837	90197	8.18	0	Extracellular matrix;Nucleus speckle	NA	Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.	The precursor is cleaved by a furin endopeptidase.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	Degradation of the extracellular matrix;O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	1
+NX_O75175	CCR4-NOT transcription complex subunit 3	753	81872	5.82	0	Cytoplasm;Cytosol;P-body;Nucleus	NA	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.	NA	Belongs to the CNOT2/3/5 family.	RNA degradation;Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	19
+NX_O75177	Calcium-responsive transactivator	396	42990	5.96	0	Nucleus;Nucleoplasm;Cytosol;Kinetochore	NA	Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).	NA	Belongs to the SS18 family.	NA	PE1	20
+NX_O75179	Ankyrin repeat domain-containing protein 17	2603	274258	6.07	0	Nucleoplasm;Cytoplasm;Nucleus membrane;Nucleus	NA	Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).	Phosphorylated by CDK2.	NA	NA	PE1	4
+NX_O75182	Paired amphipathic helix protein Sin3b	1162	133066	6.48	0	Nucleoplasm;Nucleus;Cell membrane	NA	Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.	Ubiquitinated by RNF220 that leads to proteasomal degradation.	NA	NoRC negatively regulates rRNA expression;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	19
+NX_O75185	Calcium-transporting ATPase type 2C member 2	946	103169	5.53	10	Membrane;Focal adhesion;Cell membrane	NA	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.	Ion transport by P-type ATPases	PE1	16
+NX_O75190	DnaJ homolog subfamily B member 6	326	36087	9.17	0	Cytoplasm;Nucleoplasm;Cytosol;Z line;Perinuclear region;Nucleus	Muscular dystrophy, limb-girdle, autosomal dominant 1	Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins.;But not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.	NA	NA	Regulation of HSF1-mediated heat shock response	PE1	7
+NX_O75191	Xylulose kinase	536	58382	5.55	0	Nucleus speckle	NA	Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.	NA	Belongs to the FGGY kinase family.	Pentose and glucuronate interconversions;Metabolic pathways;Formation of xylulose-5-phosphate	PE1	3
+NX_O75192	Peroxisomal membrane protein 11A	247	28353	9.68	2	Peroxisome membrane	NA	May be involved in peroxisomal proliferation and may regulate peroxisomes division (PubMed:9792670). May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).	Seems not to be N-glycosylated.	Belongs to the peroxin-11 family.	Peroxisome;PPARA activates gene expression	PE1	15
+NX_O75197	Low-density lipoprotein receptor-related protein 5	1615	179145	5.11	1	Membrane;Endoplasmic reticulum	Van Buchem disease 2;Osteopetrosis, autosomal dominant 1;Vitreoretinopathy, exudative 1;Endosteal hyperostosis, Worth type;Osteoporosis-pseudoglioma syndrome;Polycystic liver disease 4 with or without kidney cysts;Osteoporosis;Vitreoretinopathy, exudative 4;High bone mass trait	Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins (PubMed:11336703, PubMed:11448771, PubMed:15778503, PubMed:11719191, PubMed:15908424, PubMed:16252235). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11336703, PubMed:11719191). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11719191). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (PubMed:11336703, PubMed:25920554, PubMed:24706814, PubMed:14731402). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (PubMed:27228167, PubMed:16252235). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (By similarity).	Phosphorylation of cytoplasmic PPPSP motifs regulates the signal transduction of the Wnt signaling pathway through acting as a docking site for AXIN1.	Belongs to the LDLR family.	Wnt signaling pathway;TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling;Regulation of FZD by ubiquitination;RNF mutants show enhanced WNT signaling and proliferation;Disassembly of the destruction complex and recruitment of AXIN to the membrane	PE1	11
+NX_O75200	Nuclear pore complex-interacting protein family member B7	414	47714	10.35	0	Secreted	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_O75204	Transmembrane protein 127	238	25842	6.23	3	Cytoplasm;Cell membrane	Pheochromocytoma	Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.	NA	Belongs to the TMEM127 family.	NA	PE1	2
+NX_O75208	Ubiquinone biosynthesis protein COQ9, mitochondrial	318	35509	5.61	0	Mitochondrion	Coenzyme Q10 deficiency, primary, 5	Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7.	NA	Belongs to the COQ9 family.	Cofactor biosynthesis; ubiquinone biosynthesis.;Ubiquinol biosynthesis	PE1	16
+NX_O75223	Gamma-glutamylcyclotransferase	188	21008	5.07	0	Cytoplasm;Cell membrane	NA	Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.	NA	Belongs to the gamma-glutamylcyclotransferase family.	Glutathione metabolism;Glutathione synthesis and recycling	PE1	7
+NX_O75251	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	213	23564	10.02	0	Mitochondrion	Mitochondrial complex I deficiency, nuclear type 3	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	Hydroxylated ar Arg-111 by NDUFAF5 early in the pathway of assembly of complex I, before the formation of the juncture between peripheral and membrane arms.	Belongs to the complex I 20 kDa subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	19
+NX_O75264	Small integral membrane protein 24	130	14964	5.25	1	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	19
+NX_O75290	Zinc finger protein 780A	641	74531	8.96	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_O75293	Growth arrest and DNA damage-inducible protein GADD45 beta	160	17818	4.33	0	Nucleoplasm;Cytosol	NA	Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.	NA	Belongs to the GADD45 family.	MAPK signaling pathway;Cell cycle;p53 signaling pathway	PE1	19
+NX_O75298	Reticulon-2	545	59264	5.19	2	Nucleus speckle;Endoplasmic reticulum membrane	Spastic paraplegia 12, autosomal dominant	NA	NA	NA	NA	PE1	19
+NX_O75306	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	463	52546	7.21	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 6	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:12611891).	Dimethylation at Arg-118 by NDUFAF7 takes place after NDUFS2 assembles into the complex I, leading to stabilize the early intermediate complex (PubMed:24089531, PubMed:24838397).	Belongs to the complex I 49 kDa subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	1
+NX_O75309	Cadherin-16	829	89923	4.82	1	Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	NA	PE1	16
+NX_O75310	UDP-glucuronosyltransferase 2B11	529	61038	9.06	1	Microsome membrane;Endoplasmic reticulum membrane	NA	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	4
+NX_O75311	Glycine receptor subunit alpha-3	464	53800	8.6	4	Cell membrane;Postsynaptic cell membrane;Perikaryon;Synapse;Dendrite	NA	Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).	Phosphorylated by PKA; this causes down-regulation of channel activity.	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.	Neuroactive ligand-receptor interaction;Neurotransmitter receptors and postsynaptic signal transmission	PE1	4
+NX_O75312	Zinc finger protein ZPR1	459	50925	4.66	0	Cajal body;Cytoplasm;Gem;Growth cone;Nucleolus;Cytoplasmic vesicle;Axon;Perinuclear region;Nucleus	NA	Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death.	NA	Belongs to the ZPR1 family.	NA	PE1	11
+NX_O75317	Ubiquitin carboxyl-terminal hydrolase 12	370	42858	6.16	0	Nucleoplasm	NA	Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).	NA	Belongs to the peptidase C19 family. USP12/USP46 subfamily.	Ub-specific processing proteases	PE1	13
+NX_O75319	RNA/RNP complex-1-interacting phosphatase	377	43710	9.38	0	Nucleus speckle;Nucleolus;Nucleoplasm;Nucleus;Cytoskeleton	NA	Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	2
+NX_O75323	Protein NipSnap homolog 2	286	33743	9.42	0	Mitochondrion outer membrane;Cytoplasm;Mitochondrion	NA	May act as a positive regulator of L-type calcium channels.	NA	Belongs to the NipSnap family.	NA	PE1	7
+NX_O75324	Stannin	88	9497	5.19	1	Mitochondrion outer membrane;Cytosol	NA	Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288).	NA	Belongs to the stannin family.	NA	PE1	16
+NX_O75325	Leucine-rich repeat neuronal protein 2	713	78859	7.06	1	Membrane;Endoplasmic reticulum	NA	NA	NA	NA	NA	PE1	1
+NX_O75326	Semaphorin-7A	666	74824	7.57	0	Cytoplasmic vesicle;Cell membrane	NA	Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.	NA	Belongs to the semaphorin family.	Axon guidance;Other semaphorin interactions	PE1	15
+NX_O75330	Hyaluronan mediated motility receptor	724	84100	5.68	0	Cytoplasm;Cell surface;Centrosome;Cytosol;Cytoskeleton	NA	Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).	NA	NA	ECM-receptor interaction;Hyaluronan uptake and degradation;AURKA Activation by TPX2	PE1	5
+NX_O75333	T-box transcription factor TBX10	385	42341	9.33	0	Nucleus	NA	Probable transcriptional regulator involved in developmental processes.	NA	NA	NA	PE2	11
+NX_O75334	Liprin-alpha-2	1257	143291	5.8	0	Cell surface;Cytoplasm	NA	Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.	NA	Belongs to the liprin family. Liprin-alpha subfamily.	Acetylcholine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Receptor-type tyrosine-protein phosphatases	PE1	12
+NX_O75335	Liprin-alpha-4	1185	134404	6.28	0	Cell surface;Cytoplasm	NA	May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity).	NA	Belongs to the liprin family. Liprin-alpha subfamily.	Acetylcholine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Receptor-type tyrosine-protein phosphatases	PE1	1
+NX_O75339	Cartilage intermediate layer protein 1	1184	132565	8.76	0	Extracellular matrix	Intervertebral disc disease	Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.	Cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.	NA	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	PE1	15
+NX_O75340	Programmed cell death protein 6	191	21868	5.16	0	Cytoplasm;Endoplasmic reticulum membrane;COPII-coated vesicle membrane;Endosome;Cytosol;Nucleus	NA	Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779).;Has a lower Ca(2+) affinity than isoform 1 (By similarity).	NA	NA	NA	PE1	5
+NX_O75342	Arachidonate 12-lipoxygenase, 12R-type	701	80356	7.57	0	Cytoplasm;Cytosol	Ichthyosis, congenital, autosomal recessive 2	Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.	NA	Belongs to the lipoxygenase family.	Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.;Lipid metabolism; sphingolipid metabolism.;Arachidonic acid metabolism;Metabolic pathways;Synthesis of 12-eicosatetraenoic acid derivatives	PE1	17
+NX_O75343	Guanylate cyclase soluble subunit beta-2	617	70368	8.84	0	Cytoplasm	NA	NA	NA	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Smooth Muscle Contraction;Nitric oxide stimulates guanylate cyclase	PE5	13
+NX_O75344	Inactive peptidyl-prolyl cis-trans isomerase FKBP6	327	37214	6.48	0	Cytosol;Nucleus;Chromosome	NA	Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).	NA	Belongs to the FKBP6 family.	PIWI-interacting RNA (piRNA) biogenesis;Meiotic synapsis	PE1	7
+NX_O75346	Zinc finger protein 253	499	57602	9.32	0	Nucleus	NA	May function as a transcription factor. Seem to have a transcriptional repression activity.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_O75347	Tubulin-specific chaperone A	108	12855	5.25	0	Cytoplasm;Nucleolus;Cytoskeleton	NA	Tubulin-folding protein; involved in the early step of the tubulin folding pathway.	NA	Belongs to the TBCA family.	Post-chaperonin tubulin folding pathway	PE1	5
+NX_O75348	V-type proton ATPase subunit G 1	118	13758	8.93	0	Nucleoplasm;Nucleolus	NA	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).	NA	Belongs to the V-ATPase G subunit family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	9
+NX_O75351	Vacuolar protein sorting-associated protein 4B	444	49302	6.75	0	Cytoplasmic vesicle;Cytoskeleton;Late endosome membrane;Prevacuolar compartment membrane	NA	Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).	NA	Belongs to the AAA ATPase family.	Endocytosis;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT)	PE1	18
+NX_O75352	Mannose-P-dolichol utilization defect 1 protein	247	26638	9.13	7	Membrane;Endoplasmic reticulum;Mitochondrion	Congenital disorder of glycosylation 1F	Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.	NA	Belongs to the MPDU1 (TC 2.A.43.3) family.	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective MPDU1 causes MPDU1-CDG (CDG-1f)	PE1	17
+NX_O75354	Ectonucleoside triphosphate diphosphohydrolase 6	484	53246	9.32	1	Golgi apparatus;Secreted;Golgi apparatus membrane	NA	Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5'-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity).	NA	Belongs to the GDA1/CD39 NTPase family.	Purine metabolism;Pyrimidine metabolism;Phosphate bond hydrolysis by NTPDase proteins	PE1	20
+NX_O75355	Ectonucleoside triphosphate diphosphohydrolase 3	529	59105	5.98	2	Membrane	NA	Has a threefold preference for the hydrolysis of ATP over ADP.	NA	Belongs to the GDA1/CD39 NTPase family.	Purine metabolism;Pyrimidine metabolism;Phosphate bond hydrolysis by NTPDase proteins	PE1	3
+NX_O75356	Ectonucleoside triphosphate diphosphohydrolase 5	428	47517	5.92	0	Endoplasmic reticulum;Cytosol;Secreted	NA	Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.	N-glycosylated; high-mannose type (By similarity). Glycosylation is not essential for enzymatic activity.	Belongs to the GDA1/CD39 NTPase family.	Protein modification; protein glycosylation.;Purine metabolism;Pyrimidine metabolism;Phosphate bond hydrolysis by NTPDase proteins	PE1	14
+NX_O75360	Homeobox protein prophet of Pit-1	226	24984	10.36	0	Nucleus	Pituitary hormone deficiency, combined, 2	Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.	NA	Belongs to the paired homeobox family.	NA	PE1	5
+NX_O75362	Zinc finger protein 217	1048	115272	8.78	0	Nucleus speckle;Nucleus	NA	Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Estrogen-dependent gene expression	PE1	20
+NX_O75363	Breast carcinoma-amplified sequence 1	584	61709	4.99	0	Cytoplasm;Cytoplasmic vesicle	NA	Required for myelination.	NA	NA	NA	PE1	20
+NX_O75364	Pituitary homeobox 3	302	31832	9.28	0	Nucleus	Cataract 11, multiple types;Anterior segment dysgenesis 1	Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).	NA	Belongs to the paired homeobox family. Bicoid subfamily.	NA	PE1	10
+NX_O75365	Protein tyrosine phosphatase type IVA 3	173	19535	9.35	0	Early endosome;Cell membrane	NA	Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.	Farnesylated. Farnesylation is required for membrane targeting (By similarity).	Belongs to the protein-tyrosine phosphatase family.	NA	PE1	8
+NX_O75366	Advillin	819	92027	5.47	0	Axon;Cell projection;Cytoskeleton	NA	Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis.	NA	Belongs to the villin/gelsolin family.	NA	PE1	12
+NX_O75367	Core histone macro-H2A.1	372	39617	9.8	0	Nucleoplasm;Nucleus;Chromosome	NA	Binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation (PubMed:15902274). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728).;Represses SOD3 gene expression.;Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708).	Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.	NA	Systemic lupus erythematosus	PE1	5
+NX_O75368	SH3 domain-binding glutamic acid-rich-like protein	114	12774	5.22	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the SH3BGR family.	NA	PE1	X
+NX_O75369	Filamin-B	2602	278164	5.47	0	Golgi apparatus;Cell cortex;Cell membrane;Stress fiber;Cytosol;Z line;Cytoskeleton	Atelosteogenesis 3;Atelosteogenesis 1;Boomerang dysplasia;Larsen syndrome;Spondylocarpotarsal synostosis syndrome	Accelerates muscle differentiation in vitro.;Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis.	Ubiquitination by a SCF-like complex containing ASB2 isoform 2 leads to proteasomal degradation which promotes muscle differentiation.;ISGylation prevents ability to interact with the upstream activators of the JNK cascade and inhibits IFNA-induced JNK signaling.	Belongs to the filamin family.	MAPK signaling pathway;Focal adhesion;Salmonella infection;ISG15 antiviral mechanism	PE1	3
+NX_O75373	Zinc finger protein 737	536	61931	9.41	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_O75376	Nuclear receptor corepressor 1	2440	270210	6.66	0	Nucleus	NA	Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).	Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.;NCOR1 is phosphorylated by MAPK3	Belongs to the N-CoR nuclear receptor corepressors family.	PPARA activates gene expression;Downregulation of SMAD2/3:SMAD4 transcriptional activity;HDACs deacetylate histones;Notch-HLH transcription pathway;Circadian Clock;Nuclear signaling by ERBB4;Transcriptional activation of mitochondrial biogenesis;Nuclear Receptor transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);NR1D1 (REV-ERBA) represses gene expression;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Regulation of MECP2 expression and activity;Loss of MECP2 binding ability to the NCoR/SMRT complex	PE1	17
+NX_O75379	Vesicle-associated membrane protein 4	141	16397	6.75	1	Golgi apparatus;trans-Golgi network membrane	NA	Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.	NA	Belongs to the synaptobrevin family.	SNARE interactions in vesicular transport;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	1
+NX_O75380	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	124	13712	8.58	0	Mitochondrion inner membrane	Mitochondrial complex I deficiency, nuclear type 9	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFS6 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	5
+NX_O75381	Peroxisomal membrane protein PEX14	377	41237	4.89	0	Peroxisome;Peroxisome membrane;Nucleolus	Peroxisome biogenesis disorder complementation group K;Peroxisome biogenesis disorder 13A	Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.	NA	Belongs to the peroxin-14 family.	Peroxisome;E3 ubiquitin ligases ubiquitinate target proteins;Peroxisomal protein import;Class I peroxisomal membrane protein import	PE1	1
+NX_O75382	Tripartite motif-containing protein 3	744	80830	8.03	0	trans-Golgi network;Cytoplasm;Mitochondrion;Early endosome;Dendrite	NA	Probably involved in vesicular trafficking via its association with the CART complex (PubMed:15772161). The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity).	NA	Belongs to the TRIM/RBCC family.	Interferon gamma signaling	PE1	11
+NX_O75385	Serine/threonine-protein kinase ULK1	1050	112631	9.03	0	Preautophagosomal structure;Cytosol	NA	Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).	Acetylated by KAT5/TIP60 under autophagy induction, promoting protein kinase activity.;Autophosphorylated. Phosphorylated under nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. Under nutrient sufficiency, phosphorylated by MTOR/mTOR, disrupting the interaction with AMPK and preventing activation of ULK1 (By similarity). In response to nutrient limitation, phosphorylated and activated by AMPK, leading to activate autophagy.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	Regulation of autophagy;mTOR signaling pathway;Macroautophagy;RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs;Receptor Mediated Mitophagy	PE1	12
+NX_O75386	Tubby-related protein 3	442	49642	7.63	0	Cytoplasm;Cell membrane;Secreted;Cilium;Nucleolus;Nucleoplasm;Nucleus	NA	Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis.	NA	Belongs to the TUB family.	Hedgehog 'off' state	PE1	12
+NX_O75387	Large neutral amino acids transporter small subunit 3	559	61477	7.85	12	Membrane;Golgi apparatus;Cytoplasmic vesicle;Cell membrane	NA	Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.	NA	Belongs to the SLC43A transporter (TC 2.A.1.44) family.	Amino acid transport across the plasma membrane	PE1	11
+NX_O75388	Probable G-protein coupled receptor 32	356	40087	9.35	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (s) signalling events	PE2	19
+NX_O75390	Citrate synthase, mitochondrial	466	51712	8.45	0	Mitochondrion matrix;Mitochondrion	NA	NA	Methylated (PubMed:28391595, PubMed:28887308). Trimethylation at Lys-395 by CSKMT decreases citrate synthase activity (PubMed:28887308).	Belongs to the citrate synthase family.	Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.;Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Mitochondrial protein import;Citric acid cycle (TCA cycle)	PE1	12
+NX_O75391	Sperm-associated antigen 7	227	26034	7.69	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	17
+NX_O75394	39S ribosomal protein L33, mitochondrial	65	7619	10.81	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bL33 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	2
+NX_O75396	Vesicle-trafficking protein SEC22b	215	24593	6.43	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane;trans-Golgi network membrane;cis-Golgi network membrane;Melanosome	NA	SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.	NA	Belongs to the synaptobrevin family.	SNARE interactions in vesicular transport;Phagosome;Legionellosis;ER-Phagosome pathway;COPII-mediated vesicle transport;Cargo concentration in the ER;COPI-dependent Golgi-to-ER retrograde traffic	PE1	1
+NX_O75398	Deformed epidermal autoregulatory factor 1 homolog	565	59327	5.21	0	Cytoplasm;Secreted;Nucleolus;Nucleoplasm;Nucleus	Mental retardation, autosomal dominant 24;Dyskinesia, seizures, and intellectual developmental disorder	Displays greater transcriptional activity than isoform 4.;May inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3.;Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes.	May be phosphorylated by DNA-PK complex in a DNA independent manner (in vitro).;DEAF1 is phosphorylated by GSK3A	NA	NA	PE1	11
+NX_O75400	Pre-mRNA-processing factor 40 homolog A	957	108805	7.18	0	Nucleus matrix;Nucleus speckle;Nucleus	NA	Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.	NA	Belongs to the PRPF40 family.	mRNA Splicing - Major Pathway	PE1	2
+NX_O75409	Huntingtin-interacting protein M	117	13442	4.93	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_O75410	Transforming acidic coiled-coil-containing protein 1	805	87794	4.82	0	Cytoplasm;Membrane;Midbody;Centrosome;Cytosol;Nucleus	NA	Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.	Is heavily phosphorylated; isoform 6 is not.	Belongs to the TACC family.	NA	PE1	8
+NX_O75414	Nucleoside diphosphate kinase 6	186	21142	8.51	0	Cytoplasmic vesicle	NA	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.	NA	Belongs to the NDK family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways	PE1	3
+NX_O75417	DNA polymerase theta	2590	289619	7.07	0	Golgi apparatus;Chromosome;Nucleoplasm;Cytosol;Nucleus	Breast cancer	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323). POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963). POLQ-mediated MMEJ may be required to promote the survival of cells with a compromised HR repair pathway, thereby preventing genomic havoc by resolving unrepaired lesions (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-paired region using the opposing overhang as a template. Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323). The polymerase activity is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). Also exhibits low-fidelity DNA synthesis, translesion synthesis and lyase activity, and it is implicated in interstrand-cross-link repair, base excision repair and DNA end-joining (PubMed:14576298, PubMed:18503084, PubMed:19188258, PubMed:24648516). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity).	NA	Belongs to the DNA polymerase type-A family.	HDR through MMEJ (alt-NHEJ)	PE1	3
+NX_O75419	Cell division control protein 45 homolog	566	65569	5.31	0	Cytoplasm;Nucleoplasm;Centrosome;Cytosol;Nucleus	Meier-Gorlin syndrome 7	Required for initiation of chromosomal DNA replication.	NA	Belongs to the CDC45 family.	Cell cycle;Activation of ATR in response to replication stress;Activation of the pre-replicative complex;G1/S-Specific Transcription;Unwinding of DNA	PE1	22
+NX_O75420	GRB10-interacting GYF protein 1	1035	114601	5.29	0	Cytoplasmic vesicle;Cytoskeleton	NA	May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity).	NA	Belongs to the GIGYF family.	NA	PE1	7
+NX_O75425	Motile sperm domain-containing protein 3	235	25519	9.29	2	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	7
+NX_O75426	F-box only protein 24	580	64889	9.01	0	NA	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	NA	PE1	7
+NX_O75427	Leucine-rich repeat and calponin homology domain-containing protein 4	683	73450	8.55	0	Nucleoplasm;Cytosol;Focal adhesion	NA	NA	NA	NA	NA	PE1	7
+NX_O75431	Metaxin-2	263	29763	5.9	0	Mitochondrion outer membrane;Mitochondrion;Nucleolus	NA	Involved in transport of proteins into the mitochondrion.	NA	Belongs to the metaxin family.	Mitochondrial protein import;Cristae formation	PE1	2
+NX_O75436	Vacuolar protein sorting-associated protein 26A	327	38170	6.13	0	Golgi apparatus;Cytoplasm;Endosome membrane;Cell membrane;Early endosome;Endosome;Lysosome	NA	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity).	NA	Belongs to the VPS26 family.	WNT ligand biogenesis and trafficking	PE1	10
+NX_O75437	Zinc finger protein 254	659	77160	9.4	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_O75438	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	58	6961	9.03	1	Cytoplasm;Mitochondrion inner membrane;Nucleus speckle;Mitochondrion	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFB1 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	14
+NX_O75439	Mitochondrial-processing peptidase subunit beta	489	54366	6.38	0	Mitochondrion matrix;Mitochondrion	Multiple mitochondrial dysfunctions syndrome 6	Catalytic subunit of the essential mitochondrial processing protease (MPP), which is required for maturation of the majority of mitochondrial precursor proteins (PubMed:29576218). Most MPP cleavage sites follow an arginine at position -2 (By similarity).	NA	Belongs to the peptidase M16 family.	Mitochondrial protein import;Processing of SMDT1	PE1	7
+NX_O75443	Alpha-tectorin	2155	239527	5.23	0	Extracellular matrix;Cell membrane	Deafness, autosomal recessive, 21;Deafness, autosomal dominant, 12	One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.	The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	11
+NX_O75444	Transcription factor Maf	373	38492	6.44	0	Nucleus	Cataract 21, multiple types;Ayme-Gripp syndrome	Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.	Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by glucocorticoids.;Phosphorylated by GSK3 and MAPK13 on serine and threonine residues (Probable). The phosphorylation status can serve to either stimulate or inhibit transcription.	Belongs to the bZIP family. Maf subfamily.	RUNX2 regulates osteoblast differentiation	PE1	16
+NX_O75445	Usherin	5202	575600	6.4	1	Stereocilium membrane;Secreted	Retinitis pigmentosa 39;Usher syndrome 2A	Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.	NA	NA	NA	PE1	1
+NX_O75446	Histone deacetylase complex subunit SAP30	220	23306	9.28	0	Nucleoplasm;Nucleus	NA	Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.	NA	Belongs to the SAP30 family.	NoRC negatively regulates rRNA expression;HDACs deacetylate histones	PE1	4
+NX_O75448	Mediator of RNA polymerase II transcription subunit 24	989	110305	6.51	0	Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 24 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	17
+NX_O75449	Katanin p60 ATPase-containing subunit A1	491	55965	6.47	0	Cytoplasm;Cell membrane;Centriolar satellite;Nucleoplasm;Spindle pole;Centrosome;Spindle;Midbody	NA	Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.	Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.;Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.	Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.	NA	PE1	6
+NX_O75452	Retinol dehydrogenase 16	317	35673	8.83	1	Microsome membrane;Endoplasmic reticulum membrane	NA	Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:9677409, PubMed:29541409).	Not N-glycosylated.	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Cofactor metabolism; retinol metabolism.;Retinol metabolism;Metabolic pathways;The canonical retinoid cycle in rods (twilight vision);RA biosynthesis pathway	PE1	12
+NX_O75459	P antigen family member 1	146	16150	4.15	0	Nucleoplasm;Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_O75460	Serine/threonine-protein kinase/endoribonuclease IRE1	977	109735	5.98	1	Endoplasmic reticulum membrane	NA	Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262).	ADP-ribosylated by PARP16 upon ER stress, which increases both kinase and endonuclease activities.;Autophosphorylated following homodimerization. Autophosphorylation promotes activation of the endoribonuclease domain.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	Protein processing in endoplasmic reticulum;Alzheimer's disease;IRE1alpha activates chaperones	PE1	17
+NX_O75461	Transcription factor E2F6	281	31844	5.35	0	Nucleoplasm;Nucleus	NA	Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.	NA	Belongs to the E2F/DP family.	G1/S-Specific Transcription;Transcriptional Regulation by E2F6	PE1	2
+NX_O75462	Cytokine receptor-like factor 1	422	46302	9.3	0	Secreted	Crisponi/Cold-induced sweating syndrome 1	In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system.	NA	Belongs to the type I cytokine receptor family. Type 3 subfamily.	IL-6-type cytokine receptor ligand interactions;Interleukin-27 signaling	PE1	19
+NX_O75467	Zinc finger protein 324A	553	61104	9.69	0	Nucleoplasm;Cytosol;Nucleus membrane;Nucleus	NA	May be involved in transcriptional regulation. May be involved in regulation of cell proliferation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_O75469	Nuclear receptor subfamily 1 group I member 2	434	49762	8.7	0	Nucleoplasm;Nucleus	NA	Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.	NA	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors	PE1	3
+NX_O75473	Leucine-rich repeat-containing G-protein coupled receptor 5	907	99998	6.12	7	trans-Golgi network membrane;Cell membrane	NA	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.	NA	Belongs to the G-protein coupled receptor 1 family.	Regulation of FZD by ubiquitination	PE1	12
+NX_O75474	GSK-3-binding protein FRAT2	233	24051	5.4	0	Nucleoplasm;Mitochondrion	NA	Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.	NA	Belongs to the GSK-3-binding protein family.	Wnt signaling pathway;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Beta-catenin phosphorylation cascade	PE1	10
+NX_O75475	PC4 and SFRS1-interacting protein	530	60103	9.15	0	Nucleoplasm;Nucleus	NA	Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis.;May also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.;Is a more general and stronger transcriptional coactivator.	Citrullinated by PADI4.	Belongs to the HDGF family.	Vpr-mediated nuclear import of PICs;Integration of provirus;2-LTR circle formation;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection	PE1	9
+NX_O75477	Erlin-1	348	39171	7.67	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	Spastic paraplegia 62, autosomal recessive	Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618).	NA	Belongs to the band 7/mec-2 family.	ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis	PE1	10
+NX_O75478	Transcriptional adapter 2-alpha	443	51506	6.45	0	Nucleus speckle;Nucleus;Chromosome	NA	Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).	NA	NA	HATs acetylate histones	PE1	17
+NX_O75486	Transcription initiation protein SPT3 homolog	317	35793	6.41	0	Nucleoplasm;Nucleus	NA	Probable transcriptional activator.	NA	Belongs to the SPT3 family.	HATs acetylate histones	PE1	6
+NX_O75487	Glypican-4	556	62412	6.26	0	Nucleoplasm;Extracellular space;Cell membrane	NA	Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).	NA	Belongs to the glypican family.	Retinoid metabolism and transport;HS-GAG biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	X
+NX_O75489	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	264	30242	6.98	0	Mitochondrion inner membrane;Mitochondrion;Nucleus	Mitochondrial complex I deficiency, nuclear type 8	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).	NA	Belongs to the complex I 30 kDa subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	11
+NX_O75493	Carbonic anhydrase-related protein 11	328	36238	9.78	0	Cytoplasmic vesicle;Secreted;Cytoskeleton	NA	Does not have a catalytic activity.	NA	Belongs to the alpha-carbonic anhydrase family.	NA	PE1	19
+NX_O75494	Serine/arginine-rich splicing factor 10	262	31301	11.26	0	Cytoplasm;Nucleoplasm;Nucleus speckle	NA	Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).	Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock.	Belongs to the splicing factor SR family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	1
+NX_O75496	Geminin	209	23565	4.93	0	Cytoplasm;Nucleoplasm;Nucleus	Meier-Gorlin syndrome 6	Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.;Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.	Phosphorylated during mitosis. Phosphorylation at Ser-184 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity.	Belongs to the geminin family.	CDT1 association with the CDC6:ORC:origin complex;Activation of the pre-replicative complex	PE1	6
+NX_O75503	Ceroid-lipofuscinosis neuronal protein 5	358	41497	7.04	1	Membrane;Lysosome	Ceroid lipofuscinosis, neuronal, 5	Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521).	Can undergo proteolytic cleavage at the C-terminus, probably by a cysteine protease and may involve the removal of approximately 10-15 residues from the C-terminal end (PubMed:26342652).;N-glycosylated with both high mannose and complex type sugars. Glycosylation is important for proper folding and trafficking to the lysosomes.;Ceroid-lipofuscinosis neuronal protein 5: The type II membrane signal anchor is proteolytically cleaved to produce a mature form that is transported to the lysosomes (Ceroid-lipofuscinosis neuronal protein 5, secreted form) (PubMed:24038957, PubMed:20052765).	Belongs to the CLN5 family.	Lysosome	PE1	13
+NX_O75506	Heat shock factor-binding protein 1	76	8544	4.17	0	Nucleus	NA	Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.	NA	Belongs to the HSBP1 family.	Attenuation phase;HSF1-dependent transactivation;HSF1 activation	PE1	16
+NX_O75508	Claudin-11	207	21993	8.22	4	Tight junction;Cell junction;Cell membrane;Lipid droplet	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	3
+NX_O75509	Tumor necrosis factor receptor superfamily member 21	655	71845	8.09	1	Cytosol;Cell membrane	NA	Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.	NA	NA	Cytokine-cytokine receptor interaction;PPARA activates gene expression	PE1	6
+NX_O75521	Enoyl-CoA delta isomerase 2, mitochondrial	394	43585	9.13	0	Peroxisome;Mitochondrion;Peroxisome matrix	NA	Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).	NA	In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.	Fatty acid metabolism;Peroxisome;Beta-oxidation of very long chain fatty acids;Peroxisomal protein import	PE1	6
+NX_O75525	KH domain-containing, RNA-binding, signal transduction-associated protein 3	346	38800	7.04	0	Nucleoplasm;Nucleus	NA	RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation.;(Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression.	C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated.;Phosphorylated on tyrosine residues.;KHDRBS3 is phosphorylated by PTK6	Belongs to the KHDRBS family.	PTK6 Regulates Proteins Involved in RNA Processing	PE1	8
+NX_O75526	RNA-binding motif protein, X-linked-like-2	392	42814	10.33	0	Nucleus	NA	NA	NA	NA	NA	PE1	11
+NX_O75528	Transcriptional adapter 3	432	48902	5.9	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.	NA	Belongs to the NGG1 family.	HATs acetylate histones;Ub-specific processing proteases	PE1	3
+NX_O75529	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L	589	66155	5.55	0	Cytosol;Nucleus speckle;Nucleus	NA	Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity).	NA	Belongs to the WD repeat TAF5 family.	Basal transcription factors;Herpes simplex infection;HATs acetylate histones	PE1	1
+NX_O75530	Polycomb protein EED	441	50198	6.57	0	Nucleoplasm;Nucleus;Chromosome	Cohen-Gibson syndrome	Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.	Methylated. Binding to histone H1 'Lys-26' promotes mono-, di-, and trimethylation of internal lysines.	Belongs to the WD repeat ESC family.	PKMTs methylate histone lysines;Oxidative Stress Induced Senescence;PRC2 methylates histones and DNA;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Transcriptional Regulation by E2F6;Regulation of PTEN gene transcription	PE1	11
+NX_O75531	Barrier-to-autointegration factor	89	10059	5.81	0	Cytoplasm;Chromosome;Nucleoplasm;Nucleus envelope;Cytosol;Nucleus	Nestor-Guillermo progeria syndrome	(Microbial infection) Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD.;(Microbial infection) In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication.;Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging.	Ser-4 is the major site of phosphorylation as compared to Thr-2 and Thr-3. Phosphorylation on Thr-2; Thr-3 and Ser-4 disrupts its ability to bind DNA and reduces its ability to bind LEM domain-containing proteins. Non phosphorylated BAF seems to enhance binding between EMD and LMNA. Dephosphorylated by protein phosphatase 2A (PP2A) following interaction with ANKLE2/LEM4 during mitotic exit, leading to mitotic nuclear envelope reassembly.;(Microbial infection) Phosphorylated at the N-terminus by vaccinia virus (VacV) B1 kinase, leading to BANF1 relocalization to the cytoplasm, loss of dimerization and impaired DNA binding activity (PubMed:24600006, PubMed:16495336). Hyperphosphorylation is linked to the loss of ability to suppress vaccinia virus replication (PubMed:24600006).	Belongs to the BAF family.	Vpr-mediated nuclear import of PICs;Integration of provirus;Initiation of Nuclear Envelope Reformation;2-LTR circle formation;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection;Nuclear Envelope Breakdown	PE1	11
+NX_O75533	Splicing factor 3B subunit 1	1304	145830	6.65	0	Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).	Citrullinated by PADI4.;Phosphorylated. Phosphorylation occurs concomitantly with the splicing catalytic steps. Phosphorylation on Thr-244, Thr-248 and Thr-313 by cyclin-dependent kinases promotes interaction with PPP1R8 during mitosis.	Belongs to the SF3B1 family.	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;B-WICH complex positively regulates rRNA expression	PE1	2
+NX_O75534	Cold shock domain-containing protein E1	798	88885	5.88	0	Cytoplasm;Cytosol;Cell membrane	NA	RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.	NA	NA	NA	PE1	1
+NX_O75541	Zinc finger protein 821	412	46794	6.14	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	16
+NX_O75553	Disabled homolog 1	588	63775	4.88	0	Cytoplasmic vesicle	Spinocerebellar ataxia 37	Adapter molecule functioning in neural development. May regulate SIAH1 activity.	Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.	NA	Reelin signalling pathway	PE1	1
+NX_O75554	WW domain-binding protein 4	376	42507	5.45	0	Nucleus speckle;Cell membrane;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:9724750, PubMed:19592703, PubMed:28781166). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750).	NA	NA	mRNA Splicing - Major Pathway	PE1	13
+NX_O75556	Mammaglobin-B	95	10884	5.48	0	Cytoplasmic vesicle;Secreted	NA	May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.	NA	Belongs to the secretoglobin family. Lipophilin subfamily.	NA	PE1	11
+NX_O75558	Syntaxin-11	287	33196	6.11	0	Membrane;trans-Golgi network membrane	Familial hemophagocytic lymphohistiocytosis 4	SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.	NA	Belongs to the syntaxin family.	SNARE interactions in vesicular transport	PE1	6
+NX_O75563	Src kinase-associated phosphoprotein 2	359	41217	4.54	0	Nucleoplasm;Cytoplasm;Cytosol	NA	May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.	Phosphorylated in resting platelets. Phosphorylated by FYN on Tyr-261 upon T-cell activation (Probable). Dephosphorylated on Tyr-75 by PTPN22.	Belongs to the SKAP family.	Signal regulatory protein family interactions	PE1	7
+NX_O75564	Jerky protein homolog	556	61815	8.18	0	Nucleoplasm;Nucleus;Nucleolus	NA	May bind DNA.	NA	Belongs to the tigger transposable element derived protein family.	NA	PE1	8
+NX_O75569	Interferon-inducible double-stranded RNA-dependent protein kinase activator A	313	34404	8.68	0	Cytoplasm;Nucleoplasm;Perinuclear region;Cytosol	Dystonia 16	Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).	Phosphorylated at Ser-246 in unstressed cells and at Ser-287 in stressed cells. Phosphorylation at Ser-246 appears to be a prerequisite for subsequent phosphorylation at Ser-287. Phosphorylation at Ser-246 and Ser-287 are necessary for activation of EIF2AK2/PKR under conditions of stress.	Belongs to the PRKRA family.	MicroRNA (miRNA) biogenesis;Small interfering RNA (siRNA) biogenesis	PE1	2
+NX_O75570	Peptide chain release factor 1, mitochondrial	445	52306	8.75	0	Mitochondrion	NA	Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.	Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.	Belongs to the prokaryotic/mitochondrial release factor family.	NA	PE1	13
+NX_O75575	DNA-directed RNA polymerase III subunit RPC9	148	16871	5.29	0	Nucleus;Cell membrane	NA	Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.;DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).	NA	Belongs to the eukaryotic RPC9 RNA polymerase subunit family.	Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	7
+NX_O75578	Integrin alpha-10	1167	127602	6.21	1	Membrane	NA	Integrin alpha-10/beta-1 is a receptor for collagen.	NA	Belongs to the integrin alpha chain family.	Focal adhesion;ECM-receptor interaction;Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Integrin cell surface interactions;CHL1 interactions;Platelet Adhesion to exposed collagen	PE1	1
+NX_O75581	Low-density lipoprotein receptor-related protein 6	1613	180429	5.12	1	Endoplasmic reticulum;Membrane raft;Cell membrane	Coronary artery disease, autosomal dominant, 2;Tooth agenesis, selective, 7	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).	Palmitoylation on the two sites near the transmembrane domain leads to release of LRP6 from the endoplasmic reticulum.;Mono-ubiquitinated which retains LRP6 in the endoplasmic reticulum. Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.;N-glycosylation is required for cell surface location.;Dual phosphorylation of cytoplasmic PPPSP motifs sequentially by GSK3 and CK1 is required for AXIN1-binding, and subsequent stabilization and activation of beta-catenin via preventing GSK3-mediated phosphorylation of beta-catenin. Phosphorylated, in vitro, by GRK5/6 within and outside the PPPSP motifs. Phosphorylation at Ser-1490 by CDK14 during G2/M phase leads to regulation of the Wnt signaling pathway during the cell cycle. Phosphorylation by GSK3B is induced by RPSO1 binding and inhibited by DKK1. Phosphorylated, in vitro, by casein kinase I on Thr-1479.;Undergoes gamma-secretase-dependent regulated intramembrane proteolysis (RIP). The extracellular domain is first released by shedding, and then, through the action of gamma-secretase, the intracellular domain (ICD) is released into the cytoplasm where it is free to bind to GSK3B and to activate canonical Wnt signaling.;LRP6 is phosphorylated by GRK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the LDLR family.	Wnt signaling pathway;TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;Regulation of FZD by ubiquitination;RNF mutants show enhanced WNT signaling and proliferation;Disassembly of the destruction complex and recruitment of AXIN to the membrane	PE1	12
+NX_O75582	Ribosomal protein S6 kinase alpha-5	802	89865	6.63	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810).	Ubiquitinated.;Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain. Phosphorylated at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha. Autophosphorylated at Ser-750, Ser-752 and Ser-758 by the N-terminal kinase domain.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	MAPK signaling pathway;Neurotrophin signaling pathway;Bladder cancer;Recycling pathway of L1;CD209 (DC-SIGN) signaling;NCAM signaling for neurite out-growth;ERK/MAPK targets;CREB phosphorylation	PE1	14
+NX_O75586	Mediator of RNA polymerase II transcription subunit 6	246	28425	8.71	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 6 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	14
+NX_O75592	E3 ubiquitin-protein ligase MYCBP2	4678	513636	6.61	0	Nucleoplasm;Cytoplasmic vesicle;Axon;Nucleus;Cytoskeleton	NA	Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (By similarity). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity). Regulates axon guidance in the olfactory system (By similarity). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (By similarity). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (PubMed:29643511). Regulates the internalization of TRPV1 in peripheral sensory neurons (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (PubMed:18308511, PubMed:27278822). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (PubMed:9689053). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529).	Autoubiquitinated.	Belongs to the RING-Cys relay (RCR) family.	Protein modification; protein ubiquitination.	PE1	13
+NX_O75593	Forkhead box protein H1	365	39257	9.6	0	Nucleus	NA	Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).	NA	NA	Signaling by NODAL;Signaling by Activin	PE1	8
+NX_O75594	Peptidoglycan recognition protein 1	196	21731	8.92	0	Cytoplasmic granule;Secreted	NA	Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.	N-glycosylated. N-glycosylation is required for bactericidal activity.	Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.	Neutrophil degranulation;Antimicrobial peptides	PE1	19
+NX_O75596	C-type lectin domain family 3 member A	197	22233	9.07	0	Secreted	NA	Promotes cell adhesion to laminin-332 and fibronectin.	NA	NA	NA	PE1	16
+NX_O75600	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	419	45285	8.3	0	Nucleoplasm;Nucleus speckle;Nucleus;Mitochondrion	NA	NA	NA	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.;Glycine, serine and threonine metabolism;Threonine catabolism	PE1	22
+NX_O75602	Sperm-associated antigen 6	509	55476	6.37	0	Flagellum;Cytoplasm;Cytoskeleton	NA	Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.	NA	NA	NA	PE1	10
+NX_O75603	Chorion-specific transcription factor GCMb	506	56610	7.14	0	Nucleus	Hypoparathyroidism, familial isolated;Hyperparathyroidism 4	Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.	NA	NA	NA	PE1	6
+NX_O75604	Ubiquitin carboxyl-terminal hydrolase 2	605	68072	9.15	0	Cytoplasm;Cell membrane;Membrane;Cytosol;Perinuclear region;Nucleus	NA	Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19917254, PubMed:19838211).;Circadian clock output effector that regulates Ca(2+) absorption in the small intestine. Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca(2+) membrane permeability mediated by the Ca(2+) channel TRPV6 in the intestine.;Possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (PubMed:17290220, PubMed:19838211). Has no deubiquitinase activity against p53/TP53 (PubMed:17290220). Prevents MDM2-mediated degradation of MDM4 (PubMed:17290220). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (PubMed:19917254). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (By similarity). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (By similarity). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity).	NA	Belongs to the peptidase C19 family. USP2 subfamily.	TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Regulation of TP53 Degradation;Ub-specific processing proteases	PE1	11
+NX_O75607	Nucleoplasmin-3	178	19344	4.55	0	Cytosol;Nucleus;Nucleolus;Cytoskeleton	NA	Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:22362753, PubMed:20073534). Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753). Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447).	Phosphorylated.	Belongs to the nucleoplasmin family.	NA	PE1	10
+NX_O75608	Acyl-protein thioesterase 1	230	24670	6.29	0	Cytoplasm	NA	Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.	NA	Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	Glycerophospholipid metabolism;eNOS activation	PE1	8
+NX_O75610	Left-right determination factor 1	366	40880	8.6	0	Secreted	NA	Required for left-right axis determination as a regulator of LEFTY2 and NODAL.	The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.	Belongs to the TGF-beta family.	TGF-beta signaling pathway;Signaling by NODAL;Regulation of signaling by NODAL	PE1	1
+NX_O75616	GTPase Era, mitochondrial	437	48350	9.05	0	Mitochondrion matrix;Mitochondrion inner membrane;Mitochondrion;Cytosol	Perrault syndrome 6	Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	17
+NX_O75618	Death effector domain-containing protein	318	36794	9.07	0	Cytoplasm;Nucleoplasm;Nucleolus	NA	A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).	Exists predominantly in a mono- or diubiquitinated form.	NA	NA	PE1	1
+NX_O75626	PR domain zinc finger protein 1	825	91771	8.76	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).	Ubiquitinated by the SCF(FBXO11) complex, leading to its degradation by the proteasome.;Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation.	Belongs to the class V-like SAM-binding methyltransferase superfamily.	Regulation of TP53 Expression	PE1	6
+NX_O75628	GTP-binding protein REM 1	298	32947	9.02	0	NA	NA	Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.	NA	Belongs to the small GTPase superfamily. RGK family.	NA	PE1	20
+NX_O75629	Protein CREG1	220	24075	7.06	0	Cytoplasmic vesicle;Secreted;Cytoskeleton	NA	May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.	N-glycosylated.	Belongs to the CREG family.	Neutrophil degranulation	PE1	1
+NX_O75631	Uroplakin-3a	287	30670	4.69	1	Nucleus;Endoplasmic reticulum membrane;Nucleus membrane	NA	Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).	NA	Belongs to the uroplakin-3 family.	NA	PE1	22
+NX_O75635	Serpin B7	380	42905	6.34	0	Endoplasmic reticulum;Cytoplasm;Mitochondrion	Keratoderma, palmoplantar, Nagashima type	Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.	NA	Belongs to the serpin family. Ov-serpin subfamily.	NA	PE1	18
+NX_O75636	Ficolin-3	299	32903	6.2	0	Secreted	Ficolin 3 deficiency	May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.	The N-terminus is blocked.	Belongs to the ficolin lectin family.	Initial triggering of complement;Lectin pathway of complement activation;Ficolins bind to repetitive carbohydrate structures on the target cell surface	PE1	1
+NX_O75638	Cancer/testis antigen 2	210	21090	10.02	0	Nucleoplasm;Centrosome;Nucleus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the CTAG/PCC1 family.	NA	PE1	X
+NX_O75643	U5 small nuclear ribonucleoprotein 200 kDa helicase	2136	244508	5.73	0	Nucleoplasm;Nucleus	Retinitis pigmentosa 33	Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.	NA	Belongs to the helicase family. SKI2 subfamily.	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	2
+NX_O75648	Mitochondrial tRNA-specific 2-thiouridylase 1	421	47745	8.24	0	Nucleoplasm;Mitochondrion	Liver failure, infantile, transient;Deafness, aminoglycoside-induced	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.	NA	Belongs to the MnmA/TRMU family.	Sulfur relay system;tRNA modification in the mitochondrion	PE1	22
+NX_O75663	TIP41-like protein	272	31444	5.6	0	Cytoplasm;Cytosol;Cytoplasmic vesicle	NA	May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A).;Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.	NA	Belongs to the TIP41 family.	NA	PE1	1
+NX_O75665	Oral-facial-digital syndrome 1 protein	1012	116671	5.82	0	Centriole;Centriolar satellite;Cilium basal body;Nucleus;Cytoskeleton	Simpson-Golabi-Behmel syndrome 2;Retinitis pigmentosa 23;Joubert syndrome 10;Orofaciodigital syndrome 1	Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity).	NA	Belongs to the OFD1 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Hedgehog 'off' state;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	X
+NX_O75674	TOM1-like protein 1	476	52989	5.11	0	Membrane;Cytoplasm;Golgi stack;Endosome membrane	NA	Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).	Phosphorylated on tyrosines by FYN and LYN.;TOM1L1 is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	Belongs to the TOM1 family.	NA	PE1	17
+NX_O75676	Ribosomal protein S6 kinase alpha-4	772	85606	8.51	0	Nucleoplasm;Cytosol;Nucleus	NA	Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.	Ser-343 and Thr-568 phosphorylation is required for kinase activity. Ser-343 and Ser-196 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain. Phosphorylated at Ser-343, Thr-568 and Thr-687 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha. Autophosphorylated at Ser-737 and Ser-745 by the N-terminal kinase domain (By similarity).;RPS6KA4 is phosphorylated by MAPK14 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	MAPK signaling pathway;Neurotrophin signaling pathway;Recycling pathway of L1	PE1	11
+NX_O75677	Ret finger protein-like 1	317	35491	7.49	0	Cytoplasm;Nucleus	NA	Negatively regulates the G2-M phase transition, possibly by promoting cyclin B1/CCNB1 and CDK1 proteasomal degradation and thereby preventing their accumulation during interphase.	Phosphorylated by PKC and CDK1 (PubMed:20725088). The antiproliferative effect seems to be positively regulated by PKC phosphorylation and negatively by CDK1 phosphorylation (PubMed:20725088).	NA	NA	PE1	22
+NX_O75678	Ret finger protein-like 2	378	42077	8.08	0	NA	NA	NA	NA	NA	NA	PE2	22
+NX_O75679	Ret finger protein-like 3	317	35386	7.43	0	Cytoplasm;Nucleus	NA	(Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.	NA	NA	NA	PE1	22
+NX_O75683	Surfeit locus protein 6	361	41450	10.65	0	Nucleoplasm;Nucleolus	NA	Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).	NA	Belongs to the SURF6 family.	NA	PE1	9
+NX_O75688	Protein phosphatase 1B	479	52643	4.95	0	Membrane;Cytosol;Nucleolus	NA	Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.	N-myristoylation is essential for the recognition of its substrates for dephosphorylation.;Isgylation negatively regulates its activity.	Belongs to the PP2C family.	MAPK signaling pathway;ISG15 antiviral mechanism	PE1	2
+NX_O75689	Arf-GAP with dual PH domain-containing protein 1	374	43395	9.1	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).	Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro.;ADAP1 is phosphorylated by PRKCA	NA	Nuclear signaling by ERBB4	PE1	7
+NX_O75690	Keratin-associated protein 5-8	187	17519	8.24	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 5 family.	Keratinization	PE2	11
+NX_O75691	Small subunit processome component 20 homolog	2785	318385	7.07	0	Nucleolus;Cell membrane	NA	Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.	NA	Belongs to the UTP20 family.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	12
+NX_O75694	Nuclear pore complex protein Nup155	1391	155199	5.78	0	Nucleus membrane;Nuclear pore complex	Atrial fibrillation, familial, 15	Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.	Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).;Disulfide-linked to NUP62. The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC (By similarity).	Belongs to the non-repetitive/WGA-negative nucleoporin family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	5
+NX_O75695	Protein XRP2	350	39641	5	0	Nucleoplasm;Cilium;Nucleus;Cell membrane	Retinitis pigmentosa 2	Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.	Myristoylated on Gly-2; which may be required for membrane targeting.;Palmitoylated on Cys-3; which may be required for plasma membrane targeting (Probable). Mutation of Cys-3 targets the protein to internal membranes.	Belongs to the TBCC family.	Trafficking of myristoylated proteins to the cilium	PE1	X
+NX_O75711	Scrapie-responsive protein 1	98	11081	6.23	0	Secreted	NA	NA	NA	Belongs to the SCRG1 family.	NA	PE1	4
+NX_O75712	Gap junction beta-3 protein	270	30818	8.94	4	Cytoplasmic vesicle;Cell junction;Gap junction;Cell membrane	Deafness, autosomal dominant, 2B;Erythrokeratodermia variabilis et progressiva 1	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Beta-type (group I) subfamily.	Gap junction assembly	PE1	1
+NX_O75715	Epididymal secretory glutathione peroxidase	221	25202	8.83	0	Secreted	NA	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.	NA	Belongs to the glutathione peroxidase family.	Glutathione metabolism;Arachidonic acid metabolism;Detoxification of Reactive Oxygen Species	PE1	6
+NX_O75716	Serine/threonine-protein kinase 16	305	34656	6.42	0	Membrane;Cytosol;Perinuclear region	NA	Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.	It is uncertain whether palmitoylation is on Cys-6 and/or Cys-8.;Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	2
+NX_O75717	WD repeat and HMG-box DNA-binding protein 1	1129	125967	5.42	0	Nucleoplasm	NA	Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.	NA	NA	NA	PE1	14
+NX_O75718	Cartilage-associated protein	401	46562	5.5	0	Cytosol;Extracellular matrix;Cytoskeleton	Osteogenesis imperfecta 7	Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.	NA	Belongs to the leprecan family.	Collagen biosynthesis and modifying enzymes	PE1	3
+NX_O75746	Calcium-binding mitochondrial carrier protein Aralar1	678	74762	8.57	6	Cytosol;Mitochondrion inner membrane;Nucleus speckle	Epileptic encephalopathy, early infantile, 39	Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane (PubMed:11566871, PubMed:25410934). May have a function in the urea cycle (PubMed:11566871).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Mitochondrial protein import;Gluconeogenesis;Aspartate and asparagine metabolism	PE1	2
+NX_O75747	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	1445	165715	6.46	0	Membrane	NA	Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity).	NA	Belongs to the PI3/PI4-kinase family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane	PE1	12
+NX_O75751	Solute carrier family 22 member 3	556	61280	8.92	7	Membrane;Cytoplasmic vesicle;Cytosol;Nucleoplasm	NA	Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Abacavir transmembrane transport;Organic cation transport	PE1	6
+NX_O75752	UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1	331	39512	7.67	1	Cytoplasmic vesicle;Golgi apparatus membrane	NA	Transfers N-acetylgalactosamine onto globotriaosylceramide (PubMed:10993897). Plays a critical role in preimplantation stage embryonic development (By similarity).	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - globo series;Metabolic pathways;Glycosphingolipid metabolism	PE1	3
+NX_O75762	Transient receptor potential cation channel subfamily A member 1	1119	127501	6.69	6	Cell membrane	Episodic pain syndrome, familial, 1	Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).	TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal cytoplasmic domain.	Belongs to the transient receptor (TC 1.A.4) family.	TRP channels	PE1	8
+NX_O75764	Transcription elongation factor A protein 3	348	38972	9.32	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.	NA	Belongs to the TFS-II family.	NA	PE1	1
+NX_O75771	DNA repair protein RAD51 homolog 4	328	35049	5.89	0	Centrosome;Telomere;Nucleus	Breast-ovarian cancer, familial, 4	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.	NA	Belongs to the RecA family. RAD51 subfamily.	Homologous recombination;HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes	PE1	17
+NX_O75781	Paralemmin-1	387	42076	4.94	0	Dendritic spine;Filopodium membrane;Cell membrane;Apicolateral cell membrane;Basolateral cell membrane;Nucleoplasm;Axon;Dendrite	NA	Are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.;Involved in plasma membrane dynamics and cell process formation.	NA	Belongs to the paralemmin family.	NA	PE1	19
+NX_O75783	Rhomboid-related protein 1	438	48314	8.04	7	Membrane;Nucleoplasm	NA	May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.	NA	Belongs to the peptidase S54 family.	NA	PE1	16
+NX_O75787	Renin receptor	350	39008	5.76	1	Autophagosome membrane;Endoplasmic reticulum membrane;Dendritic spine membrane;Lysosome membrane;Axon	Parkinsonism with spasticity, X-linked;Mental retardation, X-linked, with epilepsy	Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton-transporting vacuolar (V)-ATPase protein pump (PubMed:12045255, PubMed:29127204). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (PubMed:12045255). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (PubMed:12045255). Probably by controlling the assembly of the V-ATPase pump and thus the acidification of the endo-lysosomal system, plays a role in many neuronal processes including synapse morphology and synaptic transmission (By similarity).	Phosphorylated.;Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments.	NA	Metabolism of Angiotensinogen to Angiotensins;Neutrophil degranulation	PE1	X
+NX_O75791	GRB2-related adapter protein 2	330	37909	6.44	0	Cytoplasm;Cell membrane;Nucleoplasm;Endosome;Cytosol;Nucleus	NA	Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.	NA	Belongs to the GRB2/sem-5/DRK family.	T cell receptor signaling pathway;Generation of second messenger molecules;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Signaling by SCF-KIT;CD28 co-stimulation	PE1	22
+NX_O75792	Ribonuclease H2 subunit A	299	33395	5.14	0	Nucleoplasm;Cytosol;Nucleus	Aicardi-Goutieres syndrome 4	Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.	NA	Belongs to the RNase HII family. Eukaryotic subfamily.	DNA replication	PE1	19
+NX_O75794	Cell division cycle protein 123 homolog	336	39135	4.64	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol	NA	Required for S phase entry of the cell cycle.	NA	Belongs to the CDC123 family.	NA	PE1	10
+NX_O75795	UDP-glucuronosyltransferase 2B17	530	61095	8.76	1	Microsome membrane;Endoplasmic reticulum membrane	NA	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	4
+NX_O75800	Zinc finger MYND domain-containing protein 10	440	50344	5.81	0	Cytoplasm;Cell membrane;Centriolar satellite;Cytosol;Apical cell membrane	Ciliary dyskinesia, primary, 22	Plays a role in axonemal structure organization and motility (PubMed:23891469, PubMed:23891471). Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity).	NA	Belongs to the ZMYND10 family.	NA	PE1	3
+NX_O75807	Protein phosphatase 1 regulatory subunit 15A	674	73478	4.55	0	Mitochondrion outer membrane;Cytoplasmic vesicle;Endoplasmic reticulum membrane	NA	Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.	Phosphorylated at multiple Ser/Thr residues. Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. Phosphorylation at Tyr-262 enhances proteasomal degradation, this position is dephosphorylated by PTPN2.;Polyubiquitinated. Exhibits a rapid proteasomal degradation with a half-life under 1 hour, ubiquitination depends on endoplasmic reticulum association.;PPP1R15A is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	Belongs to the PPP1R15 family.	Protein processing in endoplasmic reticulum;Downregulation of TGF-beta receptor signaling	PE1	19
+NX_O75808	Calpain-15	1086	117314	6.27	0	Nucleoplasm	NA	NA	NA	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	16
+NX_O75815	Breast cancer anti-estrogen resistance protein 3	825	92566	8.19	0	Cytosol;Centrosome;Cell membrane	NA	May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.	NA	NA	NA	PE1	1
+NX_O75817	Ribonuclease P protein subunit p20	140	15651	9.09	0	Cytoplasm;Cytoplasmic granule;Nucleolus;Cytoplasmic vesicle	NA	Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9630247, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).	NA	Belongs to the histone-like Alba family.	Ribosome biogenesis in eukaryotes;RNA transport;tRNA processing in the nucleus	PE1	7
+NX_O75818	Ribonuclease P protein subunit p40	363	41834	6.21	0	Nucleoplasm;Nucleolus	NA	Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9630247, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).	NA	NA	Ribosome biogenesis in eukaryotes;RNA transport;tRNA processing in the nucleus;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	6
+NX_O75820	Zinc finger protein 189	626	72976	8.85	0	Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	9
+NX_O75821	Eukaryotic translation initiation factor 3 subunit G	320	35611	5.87	0	Cytoplasm;Cytosol;Perinuclear region;Nucleus	NA	RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA.;(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).	Phosphorylated. Phosphorylation is enhanced upon serum stimulation.	Belongs to the eIF-3 subunit G family.	RNA transport;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	19
+NX_O75822	Eukaryotic translation initiation factor 3 subunit J	258	29062	4.72	0	Cytoplasm;Cytosol	NA	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).	Phosphorylated. Phosphorylation is enhanced upon serum stimulation.	Belongs to the eIF-3 subunit J family.	RNA transport;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	15
+NX_O75828	Carbonyl reductase [NADPH] 3	277	30850	5.82	0	Nucleoplasm;Cytoplasm;Cytosol	NA	Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Arachidonic acid metabolism;Metabolism of xenobiotics by cytochrome P450;Metabolic pathways;Phase I - Functionalization of compounds	PE1	21
+NX_O75829	Leukocyte cell-derived chemotaxin 1	334	37102	7.5	1	Endomembrane system;Extracellular matrix	NA	Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.	After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.	Belongs to the chondromodulin-1 family.	NA	PE1	13
+NX_O75830	Serpin I2	405	46145	5.08	0	Secreted	NA	NA	NA	Belongs to the serpin family.	NA	PE1	3
+NX_O75832	26S proteasome non-ATPase regulatory subunit 10	226	24428	5.71	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.;Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.	NA	NA	Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination & Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	X
+NX_O75838	Calcium and integrin-binding family member 2	187	21644	4.48	0	Cytoplasm;Photoreceptor inner segment;Photoreceptor outer segment;Stereocilium;Sarcolemma	Deafness, autosomal recessive, 48;Usher syndrome 1J	Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (PubMed:23023331, PubMed:26173970, PubMed:26426422). May be involved in the mechanotransduction process (By similarity).	NA	NA	NA	PE1	15
+NX_O75840	Krueppel-like factor 7	302	33362	8.19	0	Golgi apparatus;Nucleus	NA	Transcriptional factor (PubMed:9774444, PubMed:16339272). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed:28916725). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	2
+NX_O75841	Uroplakin-1b	260	29643	5.16	4	Membrane	NA	Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).	N-glycosylated with high-mannose oligosaccharides.	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	3
+NX_O75843	AP-1 complex subunit gamma-like 2	785	87117	6.09	0	Cytoplasmic vesicle membrane;Endosome membrane;Golgi apparatus membrane	NA	May function in protein sorting in late endosomes or multivesucular bodies (MVBs).;(Microbial infection) Involved in MVB-assisted maturation of hepatitis B virus (HBV).	NA	Belongs to the adaptor complexes large subunit family.	Lysosome Vesicle Biogenesis	PE1	14
+NX_O75844	CAAX prenyl protease 1 homolog	475	54813	7.11	7	Golgi apparatus;Nucleus inner membrane;Cytosol;Endoplasmic reticulum membrane	Lethal tight skin contracture syndrome;Mandibuloacral dysplasia with type B lipodystrophy	Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.	NA	Belongs to the peptidase M48A family.	NA	PE1	1
+NX_O75845	Lathosterol oxidase	299	35301	7.85	4	Endoplasmic reticulum membrane;Cell membrane;Endoplasmic reticulum;Nucleoplasm;Cytosol	Lathosterolosis	Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol.	NA	Belongs to the sterol desaturase family.	Steroid biosynthesis;Metabolic pathways;Activation of gene expression by SREBF (SREBP);Cholesterol biosynthesis via desmosterol;Cholesterol biosynthesis via lathosterol	PE1	11
+NX_O75864	Protein phosphatase 1 regulatory subunit 37	691	74767	4.97	0	Cytosol	NA	Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.	NA	Belongs to the PPP1R37 family.	NA	PE1	19
+NX_O75865	Trafficking protein particle complex subunit 6A	159	17605	5.14	0	Golgi apparatus;Endoplasmic reticulum;cis-Golgi network	NA	May play a role in vesicular transport during the biogenesis of melanosomes.	NA	Belongs to the TRAPP small subunits family. BET3 subfamily.	COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs	PE1	19
+NX_O75871	Carcinoembryonic antigen-related cell adhesion molecule 4	244	25909	6.03	1	Membrane	NA	Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles.	The cytoplasmic ITAM-like sequence becomes tyrosine phosphorylated by SRC family PTKs upon ligand-mediated receptor clustering and allows to initiate phagocytosis of bound ligand.;N-glycosylated.	Belongs to the immunoglobulin superfamily. CEA family.	NA	PE1	19
+NX_O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	414	46659	6.53	0	Peroxisome;Cytosol;Cytoplasm;Nucleus	Glioma	NA	Acetylation at Lys-374 dramatically reduces catalytic activity.	Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Citrate cycle (TCA cycle);Glutathione metabolism;Metabolic pathways;Peroxisome;Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate;NADPH regeneration;Neutrophil degranulation;Peroxisomal protein import	PE1	2
+NX_O75879	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	557	61864	8.85	0	Mitochondrion	NA	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).	NA	Belongs to the GatB/GatE family. GatB subfamily.	NA	PE1	4
+NX_O75880	Protein SCO1 homolog, mitochondrial	301	33814	9.01	1	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex IV deficiency	Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478, PubMed:15229189). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity).	NA	Belongs to the SCO1/2 family.	Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	17
+NX_O75881	Cytochrome P450 7B1	506	58256	8.2	2	Microsome membrane;Endoplasmic reticulum membrane	Congenital bile acid synthesis defect 3;Spastic paraplegia 5A, autosomal recessive	A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids (PubMed:10588945, PubMed:24491228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10588945, PubMed:24491228). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position (PubMed:10588945, PubMed:24491228). Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy steroid 7-alpha hydroxylase (PubMed:24491228). Hydroxylates oxysterols, including 25-hydroxycholesterol and (25R)-cholest-5-ene-3beta,26-diol toward 7-alpha hydroxy derivatives, which may be transported to the liver and converted to bile acids (PubMed:9802883, PubMed:10588945). Via its product 7-alpha,25-dihydroxycholesterol, a ligand for the chemotactic G protein-coupled receptor GPR183/EBI2, regulates B cell migration in germinal centers of lymphoid organs, thus guiding efficient maturation of plasma B cells and overall antigen-specific humoral immune response (By similarity). 7-alpha hydroxylates neurosteroids, including 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone) and pregnenolone, both involved in hippocampus-associated memory and learning (PubMed:24491228). Metabolizes androstanoids toward 6- or 7-alpha hydroxy derivatives (PubMed:24491228).	NA	Belongs to the cytochrome P450 family.	Steroid hormone biosynthesis.;Lipid metabolism; bile acid biosynthesis.;Primary bile acid biosynthesis;Steroid hormone biosynthesis;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol;Endogenous sterols;Synthesis of bile acids and bile salts;Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)	PE1	8
+NX_O75882	Attractin	1429	158537	7.24	1	Cytosol;Secreted;Cell membrane	NA	Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).	Heavily glycosylated.	NA	NA	PE1	20
+NX_O75884	Serine hydrolase RBBP9	186	21000	5.79	0	Nucleoplasm	NA	Serine hydrolase whose substrates have not been identified yet (PubMed:19329999, PubMed:20080647). May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (PubMed:20080647). May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699).	NA	Belongs to the RBBP9 family.	NA	PE1	20
+NX_O75886	Signal transducing adapter molecule 2	525	58164	4.94	0	Cytoplasm;Nucleoplasm;Early endosome membrane;Cytoplasmic vesicle;Cytosol	NA	Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).	Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.	Belongs to the STAM family.	Endocytosis;Jak-STAT signaling pathway;Endosomal Sorting Complex Required For Transport (ESCRT);EGFR downregulation;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Negative regulation of MET activity;InlB-mediated entry of Listeria monocytogenes into host cell	PE1	2
+NX_O75888	Tumor necrosis factor ligand superfamily member 13	250	27433	9.67	0	Secreted	NA	Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.	The precursor is cleaved by furin.	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;Intestinal immune network for IgA production;Rheumatoid arthritis;TNFs bind their physiological receptors;HuR (ELAVL1) binds and stabilizes mRNA	PE1	17
+NX_O75891	Cytosolic 10-formyltetrahydrofolate dehydrogenase	902	98829	5.63	0	Cytoplasm;Cytosol	NA	NA	NA	In the N-terminal section; belongs to the GART family.;In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	One carbon pool by folate;Metabolism of folate and pterines	PE1	3
+NX_O75896	Tumor suppressor candidate 2	110	12074	9.69	0	Cytoplasmic vesicle;Cytosol	NA	May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.	Myristoylation is required for tumor suppressor activity.	Belongs to the TUSC2 family.	NA	PE1	3
+NX_O75897	Sulfotransferase 1C4	302	35520	8.22	0	Cytoplasm;Cytosol	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).	NA	Belongs to the sulfotransferase 1 family.	Cytosolic sulfonation of small molecules	PE1	2
+NX_O75899	Gamma-aminobutyric acid type B receptor subunit 2	941	105821	8.89	7	Postsynaptic cell membrane;Cell membrane	Neurodevelopmental disorder with poor language and loss of hand skills;Epileptic encephalopathy, early infantile, 59	Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).	NA	Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors);Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;GABA B receptor activation	PE1	9
+NX_O75900	Matrix metalloproteinase-23	390	43935	9.94	1	Membrane;Endoplasmic reticulum membrane	NA	Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).	N-glycosylated.;Proteolytic cleavage might yield an active form.	Belongs to the peptidase M10A family.	NA	PE1	1
+NX_O75901	Ras association domain-containing protein 9	435	50021	5.2	0	Endosome	NA	May play a role in regulating vesicuar trafficking in cells.	NA	NA	NA	PE1	12
+NX_O75907	Diacylglycerol O-acyltransferase 1	488	55278	9.41	3	Endoplasmic reticulum;Endoplasmic reticulum membrane;Nucleolus	Diarrhea 7, protein-losing enteropathy type	Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.	NA	Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.	Lipid metabolism; glycerolipid metabolism.;Glycerolipid metabolism;Retinol metabolism;Metabolic pathways;Fat digestion and absorption;Triglyceride biosynthesis;Acyl chain remodeling of DAG and TAG;Neutrophil degranulation	PE1	8
+NX_O75908	Sterol O-acyltransferase 2	522	59896	8.96	5	Endoplasmic reticulum membrane	NA	Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.	NA	Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.	Steroid biosynthesis;LDL clearance	PE1	12
+NX_O75909	Cyclin-K	580	64240	8.6	0	Nucleoplasm;Nucleus	Intellectual developmental disorder with hypertelorism and distinctive facies	Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).	NA	Belongs to the cyclin family. Cyclin C subfamily.	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;RNA Polymerase II Pre-transcription Events;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;RNA polymerase II transcribes snRNA genes;TP53 Regulates Transcription of DNA Repair Genes	PE1	14
+NX_O75911	Short-chain dehydrogenase/reductase 3	302	33548	9.07	4	Membrane;Mitochondrion;Nucleolus	NA	Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Retinol metabolism;Metabolic pathways;RA biosynthesis pathway;The retinoid cycle in cones (daylight vision)	PE1	1
+NX_O75912	Diacylglycerol kinase iota	1065	116997	7.98	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the eukaryotic diacylglycerol kinase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Effects of PIP2 hydrolysis	PE1	7
+NX_O75914	Serine/threonine-protein kinase PAK 3	559	62310	5.33	0	Cytoplasm;Cytosol	Mental retardation, X-linked 30	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.	Neddylated.;Autophosphorylated when activated by CDC42/p21.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	ErbB signaling pathway;Axon guidance;Focal adhesion;T cell receptor signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;MAPK6/MAPK4 signaling;Generation of second messenger molecules;Ephrin signaling;VEGFR2 mediated vascular permeability;CD28 dependent Vav1 pathway;Sema3A PAK dependent Axon repulsion;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;Activation of RAC1	PE1	X
+NX_O75915	PRA1 family protein 3	188	21615	9.77	4	Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Endoplasmic reticulum;Cytoskeleton	NA	Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic.	NA	Belongs to the PRA1 family.	Glutamate Neurotransmitter Release Cycle	PE1	3
+NX_O75916	Regulator of G-protein signaling 9	674	76966	9.42	0	Membrane;Nucleoplasm;Cytoplasmic vesicle	Prolonged electroretinal response suppression	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).	Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition (By similarity).	NA	Phototransduction;G alpha (i) signalling events;Inactivation, recovery and regulation of the phototransduction cascade;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	17
+NX_O75920	Small EDRK-rich factor 1	110	12349	9.79	0	Cytosol;Nucleus	NA	Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760, PubMed:22854022, PubMed:31034892). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (PubMed:20723760, PubMed:22854022, PubMed:31034892).	NA	Belongs to the SERF family.	NA	PE1	5
+NX_O75923	Dysferlin	2080	237295	5.44	1	Sarcolemma;Centriolar satellite;Cytoplasmic vesicle membrane;Cell membrane	Distal myopathy with anterior tibial onset;Miyoshi muscular dystrophy 1;Muscular dystrophy, limb-girdle, autosomal recessive 2	Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).	NA	Belongs to the ferlin family.	Smooth Muscle Contraction	PE1	2
+NX_O75925	E3 SUMO-protein ligase PIAS1	651	71836	6.9	0	Nucleus speckle;PML body;Cytoskeleton	NA	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity).	Sumoylated.	Belongs to the PIAS family.	Protein modification; protein sumoylation.;Ubiquitin mediated proteolysis;Jak-STAT signaling pathway;Hepatitis C;Pathways in cancer;Small cell lung cancer;SUMOylation of DNA damage response and repair proteins;Regulation of IFNG signaling;Formation of Incision Complex in GG-NER;SUMOylation of transcription factors;SUMOylation of chromatin organization proteins;SUMOylation of intracellular receptors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors	PE1	15
+NX_O75928	E3 SUMO-protein ligase PIAS2	621	68240	7.47	0	Nucleoplasm;Nucleus;Nucleus speckle;PML body	NA	But not isoform PIAS2-alpha, promotes MDM2 sumoylation.;Promotes PARK7 sumoylation.;Sumoylates PML at'Lys-65' and 'Lys-160'.;Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity.;Promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha.	Sumoylated.	Belongs to the PIAS family.	Protein modification; protein sumoylation.;Ubiquitin mediated proteolysis;Jak-STAT signaling pathway;Hepatitis C;Pathways in cancer;Small cell lung cancer;SUMOylation of DNA damage response and repair proteins;Activation of anterior HOX genes in hindbrain development during early embryogenesis;SUMOylation of transcription factors;SUMOylation of chromatin organization proteins;SUMOylation of intracellular receptors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors	PE1	18
+NX_O75934	Pre-mRNA-splicing factor SPF27	225	26131	5.48	0	Nucleolus;Nucleus speckle;Centrosome;Nucleus	NA	Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).	NA	Belongs to the SPF27 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	1
+NX_O75935	Dynactin subunit 3	186	21119	5.37	0	Cytoplasm;Cleavage furrow;Nucleolus;Midbody;Centrosome;Cytosol;Spindle;Kinetochore	NA	Together with dynein may be involved in spindle assembly and cytokinesis.	NA	Belongs to the dynactin subunit 3 family.	Anchoring of the basal body to the plasma membrane;MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;AURKA Activation by TPX2;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	9
+NX_O75936	Gamma-butyrobetaine dioxygenase	387	44715	6.28	0	Cytoplasmic vesicle;Cytoplasm;Cytoskeleton	NA	Catalyzes the formation of L-carnitine from gamma-butyrobetaine.	NA	Belongs to the gamma-BBH/TMLD family.	Amine and polyamine biosynthesis; carnitine biosynthesis.;Lysine degradation;Carnitine synthesis	PE1	11
+NX_O75937	DnaJ homolog subfamily C member 8	253	29842	9.04	0	Nucleoplasm;Nucleus	NA	Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716).	NA	NA	mRNA Splicing - Major Pathway	PE1	1
+NX_O75940	Survival of motor neuron-related-splicing factor 30	238	26711	6.78	0	Cajal body;Nucleoplasm;Nucleus speckle;Nucleus	NA	Necessary for spliceosome assembly. Overexpression causes apoptosis.	NA	Belongs to the SMN family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	10
+NX_O75943	Cell cycle checkpoint protein RAD17	681	77055	6.63	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.	Phosphorylated. Phosphorylation on Ser-646 and Ser-656 is cell cycle-regulated, enhanced by genotoxic stress, and required for activation of checkpoint signaling. Phosphorylation is mediated by ATR upon UV or replication arrest, whereas it may be mediated both by ATR and ATM upon ionizing radiation. Phosphorylation on both sites is required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC4.	Belongs to the rad17/RAD24 family.	Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	5
+NX_O75947	ATP synthase subunit d, mitochondrial	161	18491	5.21	0	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.	NA	Belongs to the ATPase d subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	17
+NX_O75949	Transmembrane protein FAM155B	472	52477	8.19	2	Membrane	NA	NA	NA	Belongs to the FAM155 family.	NA	PE2	X
+NX_O75951	Lysozyme-like protein 6	148	16956	5.73	0	Cell surface;Secreted;Flagellum	NA	May be involved sperm-egg plasma membrane adhesion and fusion during fertilization (PubMed:28182716). Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus (PubMed:28182716, PubMed:24013621). Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH (PubMed:28182716). Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (PubMed:28182716).	NA	Belongs to the glycosyl hydrolase 22 family.	NA	PE1	17
+NX_O75952	Calcium-binding tyrosine phosphorylation-regulated protein	493	52774	4.51	0	Cytoplasm;Nucleoplasm;Flagellum;Cytosol;Nucleus;Cytoskeleton	NA	Do not bind calcium in vitro.;May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.;Probably bind calcium.;Probably does not bind calcium.;Binds calcium in vitro.	Is phosphorylated on tyrosine residues during in vitro capacitation.;Are phosphorylated by GSK3B in vitro. Dephosphorylation affects its ability to bind calcium.	NA	NA	PE1	18
+NX_O75953	DnaJ homolog subfamily B member 5	348	39133	9.12	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	9
+NX_O75954	Tetraspanin-9	239	26779	7.89	4	Membrane;Golgi apparatus;Cytosol;Nucleoplasm	NA	NA	Glycosylated.	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	12
+NX_O75955	Flotillin-1	427	47355	7.08	0	Golgi apparatus;Cell membrane;Endosome;Caveola;Melanosome;Cytoplasmic vesicle;Membrane raft	NA	May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.	NA	Belongs to the band 7/mec-2 family. Flotillin subfamily.	Insulin signaling pathway;Synaptic adhesion-like molecules	PE1	6
+NX_O75956	Cyclin-dependent kinase 2-associated protein 2	126	13101	9.51	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148).	Phosphorylated by MAPK1 and CDK2.	Belongs to the CDK2AP family.	NA	PE1	11
+NX_O75962	Triple functional domain protein	3097	346900	5.94	0	Cytoplasm;Cytosol;Cell projection;Cytoplasmic vesicle	Mental retardation, autosomal dominant 44	Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:22155786, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity).	Phosphorylated on serine residue(s).	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	G alpha (q) signalling events;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;DCC mediated attractive signaling	PE1	5
+NX_O75964	ATP synthase subunit g, mitochondrial	103	11428	9.65	0	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.	NA	Belongs to the ATPase g subunit family.	Oxidative phosphorylation;Metabolic pathways;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	11
+NX_O75969	A-kinase anchor protein 3	853	94751	5.84	0	Acrosome	NA	May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.	Phosphorylated on tyrosine residues.	Belongs to the AKAP110 family.	NA	PE1	12
+NX_O75970	Multiple PDZ domain protein	2070	221618	4.95	0	Cell membrane;Synaptosome;Tight junction;Postsynaptic density;Synapse;Apical cell membrane;Dendrite	Hydrocephalus, congenital, 2, with or without brain or eye anomalies	Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.	NA	NA	Tight junction	PE1	9
+NX_O75971	snRNA-activating protein complex subunit 5	98	11328	4.55	0	Nucleoplasm;Nucleus	NA	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.	NA	NA	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA polymerase II transcribes snRNA genes	PE1	15
+NX_O75973	C1q-related factor	258	26453	5.32	0	Secreted	NA	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).	NA	NA	NA	PE1	17
+NX_O75976	Carboxypeptidase D	1380	152931	5.68	1	Nucleoplasm;Nucleus speckle;Nucleus membrane;Cell membrane	NA	NA	NA	Belongs to the peptidase M14 family.	Golgi Associated Vesicle Biogenesis	PE1	17
+NX_O75995	SAM and SH3 domain-containing protein 3	380	41595	5.17	0	Nucleoplasm;Nucleus;Cell membrane	NA	May function as a signaling adapter protein in lymphocytes.	NA	NA	NA	PE1	X
+NX_O76000	Putative olfactory receptor 2B3	313	35543	8.77	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	6
+NX_O76001	Olfactory receptor 2J3	311	34950	7.6	7	Cell membrane	NA	Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE1	6
+NX_O76002	Olfactory receptor 2J2	312	35204	8.5	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_O76003	Glutaredoxin-3	335	37432	5.31	0	Cytosol;Cell cortex;Z line	NA	Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.	NA	NA	Iron uptake and transport	PE1	10
+NX_O76009	Keratin, type I cuticular Ha3-I	404	45940	4.78	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_O76011	Keratin, type I cuticular Ha4	436	49424	5.01	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_O76013	Keratin, type I cuticular Ha6	467	52247	4.9	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_O76014	Keratin, type I cuticular Ha7	449	49747	4.9	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_O76015	Keratin, type I cuticular Ha8	456	50480	4.79	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_O76021	Ribosomal L1 domain-containing protein 1	490	54973	10.13	0	Nucleolus	NA	Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.	NA	Belongs to the universal ribosomal protein uL1 family. Highly divergent.	NA	PE1	16
+NX_O76024	Wolframin	890	100292	8.34	11	Endoplasmic reticulum membrane	Wolfram syndrome 1;Deafness, autosomal dominant, 6;Cataract 41;Wolfram-like syndrome autosomal dominant	Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store.	NA	NA	Protein processing in endoplasmic reticulum;XBP1(S) activates chaperone genes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	4
+NX_O76027	Annexin A9	345	38364	5.53	0	Cytosol;Nucleus speckle	NA	Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.	NA	Belongs to the annexin family.	NA	PE1	1
+NX_O76031	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial	633	69224	7.51	0	Nucleoplasm;Cytosol;Mitochondrion;Mitochondrion nucleoid	Protoporphyria, erythropoietic, 2	ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP (PubMed:28874591). Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591). Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689, PubMed:28874591).	NA	Belongs to the ClpX chaperone family.	NA	PE1	15
+NX_O76036	Natural cytotoxicity triggering receptor 1	304	34481	7.63	1	Endoplasmic reticulum;Cell membrane	NA	Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.	N-glycosylated.;O-glycosylated.	Belongs to the natural cytotoxicity receptor (NCR) family.	Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_O76038	Secretagogin	276	32040	5.25	0	Cytoplasm;Cytosol;Secretory vesicle membrane;Secreted	NA	NA	NA	NA	NA	PE1	6
+NX_O76039	Cyclin-dependent kinase-like 5	1030	115538	9.58	0	Nucleoplasm;Cilium basal body;Centrosome;Nucleus	Epileptic encephalopathy, early infantile, 2	Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175).	Autophosphorylated.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	X
+NX_O76041	Nebulette	1014	116453	7.89	0	Cytoplasm	NA	Might play a role in the assembly of focal adhesion (PubMed:15004028).;Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623).	NA	NA	NA	PE1	10
+NX_O76042	Putative uncharacterized protein encoded by ERC2-IT1	136	14968	8.57	0	NA	NA	NA	NA	NA	NA	PE5	3
+NX_O76050	E3 ubiquitin-protein ligase NEURL1	574	61860	8.89	0	Perinuclear region;Cell membrane;Perikaryon;Postsynaptic density;Dendrite	NA	Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.	Myristoylation is a determinant of membrane targeting.	NA	Protein modification; protein ubiquitination.;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus	PE1	10
+NX_O76054	SEC14-like protein 2	403	46145	7.95	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.	NA	NA	NA	PE1	22
+NX_O76061	Stanniocalcin-2	302	33249	6.93	0	Endoplasmic reticulum;Secreted	NA	Has an anti-hypocalcemic action on calcium and phosphate homeostasis.	NA	Belongs to the stanniocalcin family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	5
+NX_O76062	Delta(14)-sterol reductase TM7SF2	418	46406	9.05	7	Microsome membrane;Cytoplasmic vesicle;Endoplasmic reticulum membrane;Endoplasmic reticulum	NA	Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.	NA	Belongs to the ERG4/ERG24 family.	Steroid biosynthesis; cholesterol biosynthesis.;Steroid biosynthesis;Metabolic pathways;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	11
+NX_O76064	E3 ubiquitin-protein ligase RNF8	485	55518	7.08	0	Cytoplasm;Nucleoplasm;Midbody;Telomere;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (PubMed:11322894, PubMed:14981089, PubMed:17724460, PubMed:18001824, PubMed:18001825, PubMed:18006705, PubMed:18077395, PubMed:18337245, PubMed:18948756, PubMed:19015238, PubMed:19124460, PubMed:19202061, PubMed:19203578, PubMed:19203579, PubMed:20550933, PubMed:21558560, PubMed:21857671, PubMed:21911360, PubMed:22266820, PubMed:22373579, PubMed:22531782, PubMed:22705371, PubMed:22865450, PubMed:22980979). Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (PubMed:23233665). In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2 (PubMed:11322894, PubMed:14981089, PubMed:17724460, PubMed:18001824, PubMed:18001825, PubMed:18006705, PubMed:18077395, PubMed:18337245, PubMed:18948756, PubMed:19015238, PubMed:19124460, PubMed:19202061, PubMed:19203578, PubMed:19203579, PubMed:20550933, PubMed:21558560, PubMed:21857671, PubMed:21911360, PubMed:22266820, PubMed:22373579, PubMed:22531782, PubMed:22705371, PubMed:22865450, PubMed:22980979).	Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.	Belongs to the RNF8 family.	Protein modification; protein ubiquitination.;G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ)	PE1	6
+NX_O76070	Gamma-synuclein	127	13331	4.89	0	Spindle;Centrosome;Nucleus;Perinuclear region	NA	Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).	Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.;SNCG is phosphorylated by PLK3;SNCG is phosphorylated by PLK2	Belongs to the synuclein family.	NA	PE1	10
+NX_O76071	Probable cytosolic iron-sulfur protein assembly protein CIAO1	339	37840	4.81	0	Nucleoplasm;Cytoplasm;Cytosol	NA	Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633).	NA	Belongs to the WD repeat CIA1 family.	Cytosolic iron-sulfur cluster assembly	PE1	2
+NX_O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	875	99985	5.74	0	Cytosol;Centriolar satellite	NA	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).	Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity). Phosphorylation by PRKG1 leads to its activation.;PDE5A is phosphorylated by PRKG1	Belongs to the cyclic nucleotide phosphodiesterase family.	Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.;Purine metabolism;cGMP effects	PE1	4
+NX_O76075	DNA fragmentation factor subunit beta	338	39110	9.2	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.	NA	NA	Apoptosis;Apoptosis induced DNA fragmentation	PE1	1
+NX_O76076	WNT1-inducible-signaling pathway protein 2	250	26825	8.32	0	Secreted	NA	May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.	NA	Belongs to the CCN family.	NA	PE1	20
+NX_O76080	AN1-type zinc finger protein 5	213	23132	8.86	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.	NA	NA	NA	PE1	9
+NX_O76081	Regulator of G-protein signaling 20	388	43692	6.48	0	Membrane;Cytoplasm;Nucleus	NA	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).	Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).;N- and O-glycosylated in synapsomal membranes.;Serine phosphorylated in synapsomal membranes.;Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).	NA	G alpha (i) signalling events;G alpha (z) signalling events	PE1	8
+NX_O76082	Solute carrier family 22 member 5	557	62752	8.07	12	Membrane;Mitochondrion	Systemic primary carnitine deficiency	Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Import of palmitoyl-CoA into the mitochondrial matrix;Organic cation transport;Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)	PE1	5
+NX_O76083	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	593	68493	5.85	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Sarcolemma;Endoplasmic reticulum;Ruffle membrane;Cytoplasmic vesicle;Perinuclear region	NA	Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.	Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.;Purine metabolism;cGMP effects	PE1	21
+NX_O76087	G antigen 7	117	12978	4.3	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE2	X
+NX_O76090	Bestrophin-1	585	67684	6.43	4	Basolateral cell membrane;Cell membrane	Bestrophinopathy, autosomal recessive;Macular dystrophy, vitelliform, 2;Retinitis pigmentosa 50;Vitreoretinochoroidopathy, autosomal dominant	Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.	Phosphorylated by PP2A.	Belongs to the bestrophin family.	Stimuli-sensing channels	PE1	11
+NX_O76093	Fibroblast growth factor 18	207	23989	9.86	0	Secreted	NA	Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR3;FGFR4 ligand binding and activation;FGFR3c ligand binding and activation;FGFR2c ligand binding and activation;FGFR3 mutant receptor activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;Phospholipase C-mediated cascade, FGFR4;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;FGFR3b ligand binding and activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;FGFRL1 modulation of FGFR1 signaling;Signaling by FGFR3 point mutants in cancer	PE1	5
+NX_O76094	Signal recognition particle subunit SRP72	671	74606	9.31	0	Endoplasmic reticulum;Cytoplasm	Bone marrow failure syndrome 1	Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.	NA	Belongs to the SRP72 family.	Protein export;SRP-dependent cotranslational protein targeting to membrane	PE1	4
+NX_O76095	Protein JTB	146	16358	8.67	1	Cytoplasm;Mitochondrion;Membrane;Centrosome;Cytoplasmic vesicle;Spindle;Cytoskeleton	NA	Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).	NA	Belongs to the JTB family.	NA	PE1	1
+NX_O76096	Cystatin-F	145	16454	8.82	0	Cytoplasm;Secreted	NA	Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.	NA	Belongs to the cystatin family.	NA	PE1	20
+NX_O76099	Olfactory receptor 7C1	320	35519	7.55	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_O76100	Olfactory receptor 7A10	309	34406	8.02	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	19
+NX_O77932	Decapping and exoribonuclease protein	396	44929	7.6	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).	NA	Belongs to the DXO/Dom3Z family.	NA	PE1	6
+NX_O94759	Transient receptor potential cation channel subfamily M member 2	1503	171198	7.27	6	Cell membrane;Perikaryon;Cell projection;Nucleus membrane;Lysosome;Cytoplasmic vesicle	NA	Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress.;Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:28775320, PubMed:29745897, PubMed:30467180). Functions as ligand-gated ion channel (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:30467180). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:29745897, PubMed:30467180). Extracellular calcium passes through the channel and increases channel activity (PubMed:19171771). Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:11960981, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:30467180). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606).;Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose.	NA	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.	TRP channels;Neutrophil degranulation	PE1	21
+NX_O94760	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	285	31122	5.53	0	Cytosol;Nucleolus;Cell membrane	NA	Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.	NA	Belongs to the DDAH family.	eNOS activation	PE1	1
+NX_O94761	ATP-dependent DNA helicase Q4	1208	133067	8.45	0	Nucleoplasm;Cytoplasm;Nucleus	Rothmund-Thomson syndrome;RAPADILINO syndrome;Baller-Gerold syndrome	DNA-dependent ATPase. May modulate chromosome segregation.	NA	Belongs to the helicase family. RecQ subfamily.	NA	PE1	8
+NX_O94762	ATP-dependent DNA helicase Q5	991	108858	8.86	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.	NA	Belongs to the helicase family. RecQ subfamily.	NA	PE1	17
+NX_O94763	Unconventional prefoldin RPB5 interactor 1	535	59832	4.92	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Dendrite;Nucleus	NA	Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.;Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.	Phosphorylated. Phosphorylation occurs essentially on serine residues. Phosphorylation occurs in response to androgen treatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated; hyperhosphorylated in mitochondria in a mTORC-dependent signaling pathway. Phosphorylated at Ser-372 by RPS6KB1 in a growth factor- and rapamycin-dependent manner. S6K1-mediated mitochondrial phosphorylation at Ser-372 disrupts the URI1-PPP1CC complex in the mitochondrion, relieves PPP1CC phosphatase inhibition activity and hence engages a negative feedback diminishing RPS6KB1 kinase activity, preventing sustained S6K1-dependent signaling.	Belongs to the RNA polymerase II subunit 5-mediating protein family.	NA	PE1	19
+NX_O94766	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3	335	37122	8.4	1	cis-Golgi network;Golgi apparatus membrane	Multiple joint dislocations, short stature, and craniofacial dysmorphism with or without congenital heart defects	Glycosaminoglycans biosynthesis (PubMed:25893793). Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation (PubMed:24425863).	N-glycosylated.	Belongs to the glycosyltransferase 43 family.	Protein modification; protein glycosylation.;Glycosaminoglycan biosynthesis - chondroitin sulfate;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;A tetrasaccharide linker sequence is required for GAG synthesis;Defective B3GAT3 causes JDSSDHD	PE1	11
+NX_O94768	Serine/threonine-protein kinase 17B	372	42344	5.13	0	Cytosol;Endoplasmic reticulum-Golgi intermediate compartment;Nucleus;Cell membrane	NA	Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.	Autophosphorylated.;STK17B is phosphorylated by PRKD2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.	NA	PE1	2
+NX_O94769	Extracellular matrix protein 2	699	79789	5.3	0	Extracellular matrix	NA	Promotes matrix assembly and cell adhesiveness.	NA	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	NA	PE1	9
+NX_O94772	Lymphocyte antigen 6H	140	14669	6.91	0	Cell membrane	NA	Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons.	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	8
+NX_O94776	Metastasis-associated protein MTA2	668	75023	9.7	0	Nucleoplasm;Nucleus	NA	May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.	NA	NA	RNA Polymerase I Transcription Initiation;HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;Regulation of PTEN gene transcription	PE1	11
+NX_O94777	Dolichol phosphate-mannose biosynthesis regulatory protein	84	9312	9.82	2	Endoplasmic reticulum membrane	Congenital disorder of glycosylation 1U	Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity.	NA	Belongs to the DPM2 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI);Synthesis of dolichyl-phosphate mannose;Defective DPM2 causes DPM2-CDG (CDG-1u);Defective DPM1 causes DPM1-CDG (CDG-1e);Defective DPM3 causes DPM3-CDG (CDG-1o)	PE1	9
+NX_O94778	Aquaporin-8	261	27381	6.41	6	Mitochondrion membrane	NA	Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family.	Bile secretion;Detoxification of Reactive Oxygen Species;Passive transport by Aquaporins	PE1	16
+NX_O94779	Contactin-5	1100	120686	5.99	0	Cell membrane	NA	Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity).	NA	Belongs to the immunoglobulin superfamily. Contactin family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	11
+NX_O94782	Ubiquitin carboxyl-terminal hydrolase 1	785	88207	5.37	0	Nucleoplasm;Nucleus	NA	Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).	Ubiquitinated; leading to its subsequent proteasomal degradation.;Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.	Belongs to the peptidase C19 family.	Fanconi anemia pathway;Recognition of DNA damage by PCNA-containing replication complex;Fanconi Anemia Pathway	PE1	1
+NX_O94788	Retinal dehydrogenase 2	518	56724	5.79	0	Cytoplasm	NA	Converts retinaldehyde to retinoic acid (PubMed:29240402). Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral (By similarity).	NA	Belongs to the aldehyde dehydrogenase family.	Cofactor metabolism; retinol metabolism.;Retinol metabolism;Metabolic pathways;RA biosynthesis pathway	PE1	15
+NX_O94804	Serine/threonine-protein kinase 10	968	112135	6.52	0	Nucleoplasm;Cell membrane	Testicular germ cell tumor	Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.	Autophosphorylates following homodimerization, leading to activation of the protein.;Autophosphorylated	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	Neutrophil degranulation	PE1	5
+NX_O94805	Actin-like protein 6B	426	46877	5.48	0	Nucleolus;Nucleus	Intellectual developmental disorder with severe speech and ambulation defects;Epileptic encephalopathy, early infantile, 76	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity). Essential for neuronal maturation and dendrite development (PubMed:31031012).	NA	Belongs to the actin family.	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	7
+NX_O94806	Serine/threonine-protein kinase D3	890	100471	6.42	0	Membrane;Cytoplasm;Cytosol;Nucleoplasm	NA	Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.	Sphingolipid de novo biosynthesis	PE1	2
+NX_O94808	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	682	76931	7.03	0	Cytoplasmic vesicle	NA	Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.	NA	NA	Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.;Alanine, aspartate and glutamate metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Synthesis of UDP-N-acetyl-glucosamine	PE1	5
+NX_O94810	Regulator of G-protein signaling 11	467	52946	8.99	0	NA	NA	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.	NA	NA	G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	16
+NX_O94811	Tubulin polymerization-promoting protein	219	23694	9.48	0	Cytoplasm;Mitochondrion;Cytosol;Nucleus;Cytoskeleton	NA	May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.	Poor substrate for GSK3 (By similarity). Phosphorylated by LIMK1 on serine residues. Phosphorylation may alter the tubulin polymerization activity.;TPPP is phosphorylated by LIMK1 (Phosphoserine:PTM-0253)	Belongs to the TPPP family.	NA	PE1	5
+NX_O94812	BAI1-associated protein 3	1187	131901	5.95	0	Cell membrane;trans-Golgi network membrane;Recycling endosome membrane;Cytosol;Late endosome membrane	NA	Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (PubMed:28626000). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity).	NA	Belongs to the unc-13 family.	NA	PE1	16
+NX_O94813	Slit homolog 2 protein	1529	169870	6.8	0	Secreted	NA	Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.	NA	NA	Axon guidance;Netrin-1 signaling;Signaling by ROBO receptors;Activation of RAC1;Inactivation of CDC42 and RAC1;Role of ABL in ROBO-SLIT signaling;Regulation of commissural axon pathfinding by SLIT and ROBO;Regulation of expression of SLITs and ROBOs;SLIT2:ROBO1 increases RHOA activity	PE1	4
+NX_O94817	Ubiquitin-like protein ATG12	140	15113	5.01	0	Cytoplasm;Preautophagosomal structure membrane	NA	Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.;(Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established (PubMed:19666601).	Acetylated by EP300.	Belongs to the ATG12 family.	Regulation of autophagy;RIG-I-like receptor signaling pathway;Macroautophagy;Negative regulators of DDX58/IFIH1 signaling;Pink/Parkin Mediated Mitophagy;Receptor Mediated Mitophagy	PE1	5
+NX_O94818	Nucleolar protein 4	638	71357	5.42	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	18
+NX_O94819	Kelch repeat and BTB domain-containing protein 11	623	65720	5.78	0	Cytoskeleton	NA	NA	NA	NA	NA	PE1	8
+NX_O94822	E3 ubiquitin-protein ligase listerin	1766	200552	5.89	0	Cytosol	NA	E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).	Autoubiquitinated.	Belongs to the LTN1 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination & Proteasome degradation	PE1	21
+NX_O94823	Probable phospholipid-transporting ATPase VB	1461	165391	6.46	10	Cytoplasmic vesicle membrane;Endoplasmic reticulum membrane	NA	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases	PE1	5
+NX_O94826	Mitochondrial import receptor subunit TOM70	608	67455	6.75	1	Mitochondrion outer membrane;Mitochondrion;Cell membrane	NA	Receptor that accelerates the import of all mitochondrial precursor proteins.	NA	Belongs to the Tom70 family.	Mitochondrial protein import;Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases	PE1	3
+NX_O94827	Pleckstrin homology domain-containing family G member 5	1062	117451	5.93	0	Cytoplasm;Cell membrane;Cell junction;Nucleoplasm;Lamellipodium;Perinuclear region	Distal spinal muscular atrophy, autosomal recessive, 4;Charcot-Marie-Tooth disease, recessive, intermediate type, C	Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation (PubMed:11704860). Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (PubMed:23777631).	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	1
+NX_O94829	Importin-13	963	108195	5.15	0	Cytoplasm;Nucleus	NA	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.	NA	Belongs to the importin beta family.	NA	PE1	1
+NX_O94830	Phospholipase DDHD2	711	81032	5.23	0	cis-Golgi network;Cytosol;Centriolar satellite;Endoplasmic reticulum-Golgi intermediate compartment	Spastic paraplegia 54, autosomal recessive	Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane.	NA	Belongs to the PA-PLA1 family.	Synthesis of PA	PE1	8
+NX_O94832	Unconventional myosin-Id	1006	116202	9.44	0	Cytoplasm;Cell cortex;Early endosome;Perikaryon;Cytosol;Dendrite	NA	Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	17
+NX_O94842	TOX high mobility group box family member 4	621	66195	4.92	0	Nucleoplasm;Nucleolus;Nucleus;Cytoplasmic vesicle	NA	Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.	NA	NA	NA	PE1	14
+NX_O94844	Rho-related BTB domain-containing protein 1	696	79417	6.42	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the small GTPase superfamily. Rho family.	Ubiquitin mediated proteolysis;Rho GTPase cycle	PE1	10
+NX_O94850	Dendrin	711	75996	10.18	0	Cytoplasm;Endoplasmic reticulum membrane;Dendritic spine membrane;Perikaryon;Nucleoplasm;Cytosol;Nucleus	NA	Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).	NA	NA	NA	PE1	12
+NX_O94851	[F-actin]-monooxygenase MICAL2	1124	126689	8.9	0	Nucleus	NA	Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334).	NA	Belongs to the Mical family.	NA	PE1	11
+NX_O94854	Uncharacterized protein KIAA0754	1291	135148	4.14	0	Cell junction;Cytoskeleton;Cell membrane	NA	NA	NA	NA	NA	PE1	1
+NX_O94855	Protein transport protein Sec24D	1032	113010	6.91	0	COPII-coated vesicle membrane;Cytosol;Endoplasmic reticulum membrane;Cytoplasmic vesicle	Cole-Carpenter syndrome 2	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).	NA	Belongs to the SEC23/SEC24 family. SEC24 subfamily.	Protein processing in endoplasmic reticulum;MHC class II antigen presentation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;Cargo concentration in the ER	PE1	4
+NX_O94856	Neurofascin	1347	150027	6.24	1	Cell membrane	NA	Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.	NA	Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.	Cell adhesion molecules (CAMs);Interaction between L1 and Ankyrins;Neurofascin interactions;Neutrophil degranulation	PE1	1
+NX_O94864	STAGA complex 65 subunit gamma	414	46193	5.01	0	Nucleoplasm;Nucleus	NA	NA	Sumoylated.	NA	HATs acetylate histones	PE1	2
+NX_O94868	F-BAR and double SH3 domains protein 2	740	84276	5.55	0	Cytoplasm;Nucleus speckle;Cell membrane;Cell junction;Focal adhesion;Clathrin-coated pit;Stereocilium;Cytoskeleton	NA	Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380).	Phosphorylated. Phosphorylation on a Ser residue is important for recruitment to the cell membrane and for its role in promoting endocytosis.	NA	NA	PE1	11
+NX_O94874	E3 UFM1-protein ligase 1	794	89595	6.35	0	Endoplasmic reticulum;Cytosol	NA	E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also play a role in nuclear receptor-mediated transcription through TRIP4 ufmylation (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (PubMed:20531390).	Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects both proteins against ubiquitination and degradation via the proteasome.	Belongs to the UFL1 family.	Antigen processing: Ubiquitination & Proteasome degradation	PE1	6
+NX_O94875	Sorbin and SH3 domain-containing protein 2	1100	124108	8.56	0	Apical cell membrane;Lamellipodium;Focal adhesion;Perinuclear region	NA	Increases water and sodium absorption in the intestine and gall-bladder.;Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503).	Ubiquitinated by CBL.;Dephosphorylated by PTPN12.;SORBS2 is phosphorylated by ABL1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	4
+NX_O94876	Transmembrane and coiled-coil domains protein 1	653	72083	6.12	2	Endoplasmic reticulum membrane	NA	Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460).	NA	Belongs to the TEX28 family.	NA	PE1	3
+NX_O94880	PHD finger protein 14	888	100053	5.22	0	Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	NA	NA	NA	NA	PE1	7
+NX_O94885	SAM and SH3 domain-containing protein 1	1247	136653	5.78	0	Nucleoplasm;Cytosol;Cytoplasm	Dyschromatosis universalis hereditaria 1;Cancer, alopecia, pigment dyscrasia, onychodystrophy, and keratoderma	Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244).	NA	NA	NA	PE1	6
+NX_O94886	CSC1-like protein 1	807	92126	6.98	10	Cytoplasmic vesicle;Lysosome membrane;Centriolar satellite	NA	Acts as an osmosensitive calcium-permeable cation channel.	NA	Belongs to the CSC1 (TC 1.A.17) family.	Neutrophil degranulation	PE1	1
+NX_O94887	FERM, ARHGEF and pleckstrin domain-containing protein 2	1054	119888	8.96	0	Cytosol	NA	Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).	NA	NA	Adherens junction;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	PE1	2
+NX_O94888	UBX domain-containing protein 7	489	54862	5.06	0	Nucleoplasm;Nucleus	NA	Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.	NA	NA	Neddylation	PE1	3
+NX_O94889	Kelch-like protein 18	574	63638	5.36	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis (PubMed:23213400). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400).	NA	NA	Protein modification; protein ubiquitination.	PE1	3
+NX_O94892	Zinc finger protein 432	652	74836	9.04	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_O94898	Leucine-rich repeats and immunoglobulin-like domains protein 2	1065	118965	5.35	1	Golgi apparatus;Nucleoplasm;Cytoplasm;Cell membrane	Urofacial syndrome 2	NA	NA	NA	NA	PE1	1
+NX_O94900	Thymocyte selection-associated high mobility group box protein TOX	526	57513	6.85	0	Nucleoplasm;Nucleolus;Nucleus	NA	May play a role in regulating T-cell development.	NA	NA	NA	PE1	8
+NX_O94901	SUN domain-containing protein 1	812	90064	6.61	1	Cytoplasm;Nucleus membrane;Nucleus inner membrane	NA	As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenenis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709).	The disulfid bond with KASH domain containing nesprins is required for stability of the respective LINC complexes under tensile forces.	NA	Meiotic synapsis	PE1	7
+NX_O94903	Pyridoxal phosphate homeostasis protein	275	30344	7.09	0	Cytoplasm;Cytosol;Nucleus	Epilepsy, early-onset, vitamin B6-dependent	Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.	NA	Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	NA	PE1	8
+NX_O94905	Erlin-2	339	37840	5.47	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	Spastic paraplegia 18, autosomal recessive	Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618).	NA	Belongs to the band 7/mec-2 family.	Signaling by FGFR1 in disease;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;Signaling by plasma membrane FGFR1 fusions	PE1	8
+NX_O94906	Pre-mRNA-processing factor 6	941	106925	8.49	0	Nucleoplasm;Nucleus speckle	Retinitis pigmentosa 60	Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:28781166, PubMed:21549338). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.	NA	NA	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	20
+NX_O94907	Dickkopf-related protein 1	266	28672	8.8	0	Secreted	NA	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).	NA	Belongs to the dickkopf family.	Wnt signaling pathway;TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	PE1	10
+NX_O94910	Adhesion G protein-coupled receptor L1	1474	162717	6.17	7	Presynaptic cell membrane;Synaptosome;Cell membrane;Growth cone;Synapse;Axon	NA	Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity).	Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus (By similarity).	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	19
+NX_O94911	ATP-binding cassette sub-family A member 8	1581	179245	6.81	14	Nucleoplasm;Cytosol;Cell membrane	NA	ATP-dependent lipophilic drug transporter.	NA	Belongs to the ABC transporter superfamily. ABCA family.	ABC transporters;ABC-family proteins mediated transport	PE1	17
+NX_O94913	Pre-mRNA cleavage complex 2 protein Pcf11	1555	173050	8.65	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Component of pre-mRNA cleavage complex II.	NA	NA	mRNA surveillance pathway;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA polymerase II transcribes snRNA genes;RNA Polymerase II Transcription Termination	PE1	11
+NX_O94915	Protein furry homolog-like	3013	339598	5.36	0	Cytosol;Cytoskeleton	NA	Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.	NA	Belongs to the furry protein family.	NA	PE1	4
+NX_O94916	Nuclear factor of activated T-cells 5	1531	165763	5.12	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394).	Phosphorylated (PubMed:10377394). Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization (PubMed:21209322).	NA	Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;HTLV-I infection	PE1	16
+NX_O94919	Endonuclease domain-containing 1 protein	500	55017	5.55	0	Secreted;Nucleus membrane	NA	May act as a DNase and a RNase.	NA	Belongs to the DNA/RNA non-specific endonuclease family.	Platelet degranulation	PE1	11
+NX_O94921	Cyclin-dependent kinase 14	469	53057	9.06	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	7
+NX_O94923	D-glucuronyl C5-epimerase	617	70101	9.04	1	Mitochondrion;Golgi apparatus membrane	NA	Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.	NA	Belongs to the D-glucuronyl C5-epimerase family.	Glycan metabolism; heparin biosynthesis.;Glycan metabolism; heparan sulfate biosynthesis.;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;HS-GAG biosynthesis	PE1	15
+NX_O94925	Glutaminase kidney isoform, mitochondrial	669	73461	7.85	0	Mitochondrion matrix;Mitochondrion;Cytosol	Infantile cataract, skin abnormalities, glutamate excess, and impaired intellectual development;Global developmental delay, progressive ataxia, and elevated glutamine;Epileptic encephalopathy, early infantile, 71	Lacks catalytic activity.;Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30575854, PubMed:30239721, PubMed:30970188).	Synthesized as a 74-kDa cytosolic precursor which is proteolytically processed by the mitochondrial-processing peptidase (MPP) via a 72-kDa intermediate to yield the mature mitochondrial 68- and 65-kDa subunits.	Belongs to the glutaminase family.	Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;D-Glutamine and D-glutamate metabolism;Nitrogen metabolism;Metabolic pathways;Glutamatergic synapse;GABAergic synapse;Proximal tubule bicarbonate reclamation;TP53 Regulates Metabolic Genes;Glutamate Neurotransmitter Release Cycle;Glutamate and glutamine metabolism	PE1	2
+NX_O94927	HAUS augmin-like complex subunit 5	633	71682	8.83	0	Spindle;Centrosome	NA	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.	NA	Belongs to the HAUS5 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	19
+NX_O94929	Actin-binding LIM protein 3	683	77802	8.86	0	Cytoplasm;Nucleoplasm;Cell junction;Cell membrane	NA	May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.	NA	NA	Axon guidance;DCC mediated attractive signaling	PE1	5
+NX_O94933	SLIT and NTRK-like protein 3	977	108934	7.03	1	Membrane;Mitochondrion	NA	Suppresses neurite outgrowth.	NA	Belongs to the SLITRK family.	Receptor-type tyrosine-protein phosphatases	PE1	3
+NX_O94941	RING finger protein 37	541	58966	7.53	0	Nucleoplasm;Nucleus	NA	May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.	NA	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination & Proteasome degradation	PE1	20
+NX_O94952	F-box only protein 21	628	72270	5.73	0	Mitochondrion	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	Antigen processing: Ubiquitination & Proteasome degradation;Neddylation	PE1	12
+NX_O94953	Lysine-specific demethylase 4B	1096	121897	6.72	0	Nucleoplasm;Cytosol;Nucleus	NA	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.	NA	Belongs to the JHDM3 histone demethylase family.	HDMs demethylate histones;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Estrogen-dependent gene expression	PE1	19
+NX_O94955	Rho-related BTB domain-containing protein 3	611	69413	7.72	0	Golgi apparatus;Cytoplasmic vesicle	NA	Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.	NA	NA	Retrograde transport at the Trans-Golgi-Network	PE1	5
+NX_O94956	Solute carrier organic anion transporter family member 2B1	709	76711	8.7	12	Cell membrane	NA	Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.	NA	Belongs to the organo anion transporter (TC 2.A.60) family.	Transport of organic anions	PE1	11
+NX_O94964	Protein SOGA1	1423	159760	6.08	0	Cytosol;Secreted;Nucleolus	NA	Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.	Proteolytically cleaved in primary hepatocytes into a C-terminal 80 kDa form (By similarity). Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma.	Belongs to the SOGA family.	NA	PE1	20
+NX_O94966	Ubiquitin carboxyl-terminal hydrolase 19	1318	145651	5.89	1	Endoplasmic reticulum membrane	NA	Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains.	NA	Belongs to the peptidase C19 family.	Ub-specific processing proteases	PE1	3
+NX_O94967	WD repeat-containing protein 47	919	101949	5.59	0	Nucleoplasm;Cytoskeleton	NA	NA	NA	NA	NA	PE1	1
+NX_O94972	E3 ubiquitin-protein ligase TRIM37	964	107906	5.04	0	Peroxisome;Perinuclear region	Mulibrey nanism	E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).	Auto-ubiquitinated.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination & Proteasome degradation	PE1	17
+NX_O94973	AP-2 complex subunit alpha-2	939	103960	6.53	0	Cytoplasmic vesicle;Coated pit;Nucleoplasm;Cell membrane	NA	Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).	NA	Belongs to the adaptor complexes large subunit family.	Endocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Huntington's disease;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Retrograde neurotrophin signalling;Recycling pathway of L1;Nef Mediated CD8 Down-regulation;WNT5A-dependent internalization of FZD4;Nef Mediated CD4 Down-regulation;Trafficking of GluR2-containing AMPA receptors;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;Neutrophil degranulation;LDL clearance	PE1	11
+NX_O94979	Protein transport protein Sec31A	1220	133015	6.43	0	Cytoplasm;Endoplasmic reticulum membrane;COPII-coated vesicle membrane;Cytoplasmic vesicle;Cytosol	NA	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).	Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.	Belongs to the WD repeat SEC31 family.	Protein processing in endoplasmic reticulum;MHC class II antigen presentation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;XBP1(S) activates chaperone genes;COPII-mediated vesicle transport	PE1	4
+NX_O94983	Calmodulin-binding transcription activator 2	1202	131530	6.92	0	Nucleoplasm;Mitochondrion;Nucleus;Cytoskeleton	NA	Transcription activator. May act as tumor suppressor.	NA	Belongs to the CAMTA family.	NA	PE1	17
+NX_O94985	Calsyntenin-1	981	109793	4.81	1	Endoplasmic reticulum membrane;Postsynaptic cell membrane;Golgi apparatus membrane;Neuron projection;Nucleus	NA	Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).	Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by presenilin gamma-secretase within the transmembrane domain releases the beta-Alc-alpha chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1.	NA	NA	PE1	1
+NX_O94986	Centrosomal protein of 152 kDa	1710	195626	5.45	0	Centrosome;Centriole	Microcephaly 9, primary, autosomal recessive;Seckel syndrome 5	Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).	NA	Belongs to the CEP152 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	15
+NX_O94988	Protein FAM13A	1023	116932	6.07	0	Cytosol;Cell junction;Nucleolus	NA	NA	NA	Belongs to the FAM13 family.	Rho GTPase cycle	PE1	4
+NX_O94989	Rho guanine nucleotide exchange factor 15	841	91940	8.61	0	Dendrite;Cell membrane	NA	Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.	Ubiquitinated; UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse formation.;Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-353 triggers UBE3A-mediated ubiquitination (By similarity).	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	17
+NX_O94991	SLIT and NTRK-like protein 5	958	107486	6.48	1	Membrane;Golgi apparatus;Nucleoplasm	NA	Suppresses neurite outgrowth.	NA	Belongs to the SLITRK family.	Receptor-type tyrosine-protein phosphatases	PE1	13
+NX_O94992	Protein HEXIM1	359	40623	4.84	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).	NA	Belongs to the HEXIM family.	NA	PE1	17
+NX_O94993	Transcription factor SOX-30	753	81854	6.92	0	Nucleus	NA	Transcriptional activator. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif.	NA	NA	NA	PE1	5
+NX_O95006	Olfactory receptor 2F2	317	35294	8.66	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_O95007	Olfactory receptor 6B1	311	35299	8.82	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_O95013	Olfactory receptor 4F21	312	35094	9.03	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	8
+NX_O95025	Semaphorin-3D	777	89651	7.94	0	Golgi apparatus;Secreted;Cell membrane	NA	Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity).	NA	Belongs to the semaphorin family.	Axon guidance	PE1	7
+NX_O95045	Uridine phosphorylase 2	317	35527	6.21	0	Nucleoplasm;Mitochondrion;Cytoplasmic vesicle	NA	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.	NA	Belongs to the PNP/UDP phosphorylase family.	Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.;Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine catabolism;Pyrimidine salvage	PE1	2
+NX_O95047	Olfactory receptor 2A4	310	34802	9.18	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_O95049	Tight junction protein ZO-3	919	101397	6.29	0	Cell membrane;Cell junction;Nucleoplasm;Tight junction;Nucleus	NA	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity).	Phosphorylated (By similarity).	Belongs to the MAGUK family.	Tight junction	PE1	19
+NX_O95050	Indolethylamine N-methyltransferase	263	28891	5.15	0	Golgi apparatus;Cytoplasm;Cytoplasmic vesicle	NA	Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.	Tryptophan metabolism;Selenocompound metabolism;Methylation of MeSeH for excretion	PE1	7
+NX_O95057	GTP-binding protein Di-Ras1	198	22329	8.94	0	Cell membrane	NA	Displays low GTPase activity and exists predominantly in the GTP-bound form.	NA	Belongs to the small GTPase superfamily. Di-Ras family.	NA	PE1	19
+NX_O95059	Ribonuclease P protein subunit p14	124	13693	7.62	0	Nucleoplasm;Cytosol;Nucleolus	NA	Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.	NA	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.	RNA transport;tRNA processing in the nucleus;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	3
+NX_O95067	G2/mitotic-specific cyclin-B2	398	45282	9	0	Golgi apparatus;Cytosol;Cytoskeleton	NA	Essential for the control of the cell cycle at the G2/M (mitosis) transition.	NA	Belongs to the cyclin family. Cyclin AB subfamily.	Cell cycle;Oocyte meiosis;p53 signaling pathway;Progesterone-mediated oocyte maturation;HTLV-I infection;Nuclear Pore Complex (NPC) Disassembly;Activation of NIMA Kinases NEK9, NEK6, NEK7;Regulation of PLK1 Activity at G2/M Transition;Resolution of Sister Chromatid Cohesion;Polo-like kinase mediated events;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;Golgi Cisternae Pericentriolar Stack Reorganization;Condensation of Prometaphase Chromosomes;The role of GTSE1 in G2/M progression after G2 checkpoint	PE1	15
+NX_O95069	Potassium channel subfamily K member 2	426	47093	8.46	4	Endoplasmic reticulum membrane;Cell membrane	NA	Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.;Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).	Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel.	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Gastric acid secretion;TWIK related potassium channel (TREK);Phase 4 - resting membrane potential	PE1	1
+NX_O95070	Protein YIF1A	293	32011	8.98	5	Golgi apparatus;Endoplasmic reticulum membrane;Centriolar satellite;Golgi apparatus membrane;Cytoplasmic vesicle	NA	Possible role in transport between endoplasmic reticulum and Golgi.	NA	Belongs to the YIF1 family.	XBP1(S) activates chaperone genes	PE1	11
+NX_O95071	E3 ubiquitin-protein ligase UBR5	2799	309352	5.59	0	Nucleoplasm;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.	UBR5 is phosphorylated by MAPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis	PE1	8
+NX_O95072	Meiotic recombination protein REC8 homolog	547	62614	5	0	Nucleoplasm;Centromere;Nucleus;Chromosome	NA	Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity).	Phosphorylated.	Belongs to the rad21 family.	Oocyte meiosis;Meiotic synapsis	PE1	14
+NX_O95073	Fibrinogen silencer-binding protein	299	34768	6.62	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.	NA	NA	Homologous recombination	PE1	8
+NX_O95076	Homeobox protein aristaless-like 3	343	36935	8.81	0	Nucleus;Nucleolus	Frontonasal dysplasia 1	Transcriptional regulator with a possible role in patterning of mesoderm during development.	NA	Belongs to the paired homeobox family.	NA	PE1	1
+NX_O95081	Arf-GAP domain and FG repeat-containing protein 2	481	48963	9.28	0	NA	NA	NA	NA	NA	NA	PE1	7
+NX_O95084	Serine protease 23	383	43001	9.48	0	Golgi apparatus;Secreted	NA	NA	NA	Belongs to the peptidase S1 family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	11
+NX_O95096	Homeobox protein Nkx-2.2	273	30133	7.81	0	Nucleus	NA	Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).	NA	Belongs to the NK-2 homeobox family.	Maturity onset diabetes of the young;Regulation of gene expression in beta cells;Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	PE1	20
+NX_O95104	SR-related and CTD-associated factor 4	1147	125869	9.58	0	Nucleoplasm;Nucleus	NA	Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF8, also acts as a suppressor of transcriptional readthrough (PubMed:31104839).	NA	NA	NA	PE1	21
+NX_O95125	Zinc finger protein 202	648	74720	5.63	0	Nucleolus;Nucleus	NA	Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.	NA	NA	Generic Transcription Pathway	PE1	11
+NX_O95136	Sphingosine 1-phosphate receptor 2	353	38867	9.21	7	Golgi apparatus;Nucleus speckle;Cell membrane	Deafness, autosomal recessive, 68	Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Lysosphingolipid and LPA receptors	PE1	19
+NX_O95139	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	128	15489	9.63	1	Mitochondrion inner membrane;Mitochondrion	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFB6 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	9
+NX_O95140	Mitofusin-2	757	86402	6.52	2	Mitochondrion outer membrane	Charcot-Marie-Tooth disease 2A2B;Charcot-Marie-Tooth disease 2A2A;Neuropathy, hereditary motor and sensory, 6A	Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity).	Phosphorylated by PINK1.;Ubiquitinated by non-degradative ubiquitin by PRKN, promoting mitochondrial fusion; deubiquitination by USP30 inhibits mitochondrial fusion.	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.	Factors involved in megakaryocyte development and platelet production;Pink/Parkin Mediated Mitophagy	PE1	1
+NX_O95147	Dual specificity protein phosphatase 14	198	22255	9.62	0	Nucleoplasm;Cytosol	NA	Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway	PE1	17
+NX_O95149	Snurportin-1	360	41143	6.17	0	Cytoplasm;Nucleus;Nucleus membrane	NA	Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.	NA	Belongs to the snurportin family.	RNA transport;snRNP Assembly	PE1	15
+NX_O95150	Tumor necrosis factor ligand superfamily member 15	251	28087	6.31	1	Secreted;Nucleus membrane;Membrane;Nucleoplasm;Cytosol	NA	Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.	NA	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	9
+NX_O95153	Peripheral-type benzodiazepine receptor-associated protein 1	1857	200051	5.05	0	Cytoplasm;Mitochondrion	NA	NA	NA	Belongs to the RIMBP family.	Acetylcholine Neurotransmitter Release Cycle;Pregnenolone biosynthesis;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle	PE1	17
+NX_O95154	Aflatoxin B1 aldehyde reductase member 3	331	37206	6.67	0	Cytoplasm	NA	Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.	NA	Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.	Metabolism of xenobiotics by cytochrome P450;Aflatoxin activation and detoxification	PE1	1
+NX_O95155	Ubiquitin conjugation factor E4 B	1302	146185	6.13	0	Cytoplasm;Nucleus	NA	Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820).	Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.	Belongs to the ubiquitin conjugation factor E4 family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum	PE1	1
+NX_O95156	Neurexophilin-2	264	29938	8.95	0	Secreted	NA	May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.	May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.	Belongs to the neurexophilin family.	NA	PE2	2
+NX_O95157	Neurexophilin-3	252	28127	8.82	0	Secreted	NA	May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).	May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.	Belongs to the neurexophilin family.	NA	PE1	17
+NX_O95158	Neurexophilin-4	308	33065	9.89	0	Secreted	NA	May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.	May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.	Belongs to the neurexophilin family.	NA	PE1	12
+NX_O95159	Zinc finger protein-like 1	310	34114	8.42	1	Golgi apparatus;cis-Golgi network membrane	NA	Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.	Phosphorylated.	Belongs to the ZFPL1 family.	NA	PE1	11
+NX_O95163	Elongator complex protein 1	1332	150254	5.61	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Neuropathy, hereditary sensory and autonomic, 3	Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in neurogenesis (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059).	NA	Belongs to the ELP1/IKA1 family.	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.;HATs acetylate histones	PE1	9
+NX_O95164	Ubiquitin-like protein 3	117	13157	6.27	0	Cytoplasm;Centrosome;Nucleus;Cell membrane	NA	NA	NA	NA	NA	PE1	13
+NX_O95166	Gamma-aminobutyric acid receptor-associated protein	117	13918	8.73	0	Endomembrane system;Autophagosome;Golgi apparatus membrane;Cytoplasmic vesicle;Cytoskeleton	NA	Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:15977068). Through its interaction with the reticulophagy receptor TEX264, paticipates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538).	The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAP-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAP-II.	Belongs to the ATG8 family.	Regulation of autophagy;GABAergic synapse;Macroautophagy;TBC/RABGAPs	PE1	17
+NX_O95167	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	84	9279	8.01	1	Mitochondrion inner membrane	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFA3 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	19
+NX_O95168	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	129	15209	9.85	1	Mitochondrion inner membrane;Mitochondrion;Nucleus membrane	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFB4 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	3
+NX_O95169	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	186	21766	6.29	1	Endoplasmic reticulum;Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 32	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFB8 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Mitochondrial protein import;Respiratory electron transport;Complex I biogenesis	PE1	10
+NX_O95170	CMT1A duplicated region transcript 1 protein	752	85370	9.23	0	NA	NA	NA	NA	NA	NA	PE2	17
+NX_O95171	Sciellin	688	77552	9.42	0	Cytoplasm;Cell membrane;Membrane;Nucleoplasm;Cytosol	NA	May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.	NA	NA	NA	PE1	13
+NX_O95177	Uncharacterized protein GAS8-AS1	125	12619	8.04	0	NA	NA	NA	NA	NA	NA	PE5	16
+NX_O95178	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	105	12058	5.47	0	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFB2 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	7
+NX_O95180	Voltage-dependent T-type calcium channel subunit alpha-1H	2353	259163	7.13	24	Cytoplasmic vesicle;Nucleoplasm;Cell membrane	Hyperaldosteronism, familial, 4;Epilepsy, childhood absence 6;Epilepsy, idiopathic generalized 6	Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216).	In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1H subfamily.	MAPK signaling pathway;Calcium signaling pathway;NCAM1 interactions	PE1	16
+NX_O95182	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	113	12551	10.19	0	Cytoplasm;Mitochondrion inner membrane;Mitochondrion;Cell membrane	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFA7 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	19
+NX_O95183	Vesicle-associated membrane protein 5	116	12805	7.7	1	Nucleoplasm;Endomembrane system;trans-Golgi network membrane;Cell membrane	NA	May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.	(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 40-Arg-|-Ser-41 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.	Belongs to the synaptobrevin family.	SNARE interactions in vesicular transport	PE1	2
+NX_O95185	Netrin receptor UNC5C	931	103146	5.74	1	Synaptosome;Cell membrane;Growth cone;Cell surface;Lamellipodium;Filopodium;Axon;Dendrite	Alzheimer disease	Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).	Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.;Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent.	Belongs to the unc-5 family.	Axon guidance;Netrin mediated repulsion signals	PE1	4
+NX_O95190	Ornithine decarboxylase antizyme 2	189	21011	5.21	0	Golgi apparatus;Nucleus	NA	Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity).	NA	Belongs to the ODC antizyme family.	Regulation of ornithine decarboxylase (ODC)	PE1	15
+NX_O95196	Chondroitin sulfate proteoglycan 5	566	60016	4.39	1	Endoplasmic reticulum membrane;Mitochondrion;Cell membrane;Cell surface;Nucleoplasm;Golgi apparatus membrane	NA	May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.	N-glycosylated.;Phosphorylated; in intracellular and extracellular parts.;O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation (By similarity).	NA	Chondroitin sulfate biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Dermatan sulfate biosynthesis;CS/DS degradation;Defective CHST3 causes SEDCJD;Defective CHST14 causes EDS, musculocontractural type;Defective CHSY1 causes TPBS;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	3
+NX_O95197	Reticulon-3	1032	112611	4.85	0	Endoplasmic reticulum;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671).	NA	NA	Synaptic adhesion-like molecules	PE1	11
+NX_O95198	Kelch-like protein 2	593	65975	6.3	0	Cell projection;Nucleoplasm;Lamellipodium;Ruffle;Cytoplasmic vesicle;Cytosol;Cytoskeleton	NA	Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.	NA	NA	Antigen processing: Ubiquitination & Proteasome degradation;Neddylation	PE1	4
+NX_O95199	RCC1 and BTB domain-containing protein 2	551	60315	5.29	0	Golgi apparatus;Nucleoplasm;Acrosome	NA	NA	NA	NA	NA	PE1	13
+NX_O95201	Zinc finger protein 205	554	60630	8.88	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_O95202	Mitochondrial proton/calcium exchanger protein	739	83354	6.3	1	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248).	NA	Belongs to the LETM1 family.	Mitochondrial calcium ion transport	PE1	4
+NX_O95206	Protocadherin-8	1070	113019	5.35	1	Golgi apparatus;Presynaptic cell membrane;Cell membrane;Postsynaptic cell membrane;Cytosol;Dendrite	NA	Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity).	NA	NA	NA	PE1	13
+NX_O95208	Epsin-2	641	68482	7.11	0	Clathrin-coated vesicle;Cytoplasm;Cytoplasmic vesicle	NA	Plays a role in the formation of clathrin-coated invaginations and endocytosis.	Ubiquitinated.;EPN2 is phosphorylated by MAPK3	Belongs to the epsin family.	Endocytosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	17
+NX_O95210	Starch-binding domain-containing protein 1	358	39007	5.46	1	Cytosol;Preautophagosomal structure membrane;Endoplasmic reticulum membrane;T-tubule	NA	Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.	Ubiquitinated, which leads to proteasomal degradation.	NA	Neutrophil degranulation	PE1	4
+NX_O95214	Leptin receptor overlapping transcript-like 1	131	14428	5.55	4	Membrane	NA	Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.	NA	Belongs to the OB-RGRP/VPS55 family.	NA	PE1	8
+NX_O95218	Zinc finger Ran-binding domain-containing protein 2	330	37404	10.03	0	Nucleoplasm;Nucleus	NA	Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.	Is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.	Belongs to the ZRANB2 family.	NA	PE1	1
+NX_O95219	Sorting nexin-4	450	51909	5.69	0	Early endosome membrane;Early endosome	NA	Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.	NA	Belongs to the sorting nexin family.	NA	PE1	3
+NX_O95221	Olfactory receptor 5F1	314	35132	8.9	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_O95222	Olfactory receptor 6A2	327	36154	8.4	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_O95229	ZW10 interactor	277	31293	5.1	0	Kinetochore;Nucleoplasm;Cytosol;Nucleus	NA	Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.	NA	NA	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	10
+NX_O95231	Homeobox protein VENTX	258	27552	9.74	0	Nucleus;Nucleolus;Cytosol	NA	May be involved in ventralization.	NA	NA	NA	PE1	10
+NX_O95232	Luc7-like protein 3	432	51466	9.81	0	Nucleus speckle	NA	Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.	Phosphorylated in vitro by SRPK1, SRPK2 and CLK1.	Belongs to the Luc7 family.	NA	PE1	17
+NX_O95235	Kinesin-like protein KIF20A	890	100278	6.49	0	Golgi apparatus;Cleavage furrow;Nucleoplasm;Spindle;Cytoskeleton	NA	Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.	Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	MHC class II antigen presentation;Kinesins;Mitotic Telophase/Cytokinesis;COPI-dependent Golgi-to-ER retrograde traffic	PE1	5
+NX_O95236	Apolipoprotein L3	402	44278	8.4	0	Cytoplasm	NA	May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	NA	Belongs to the apolipoprotein L family.	NA	PE1	22
+NX_O95237	Lecithin retinol acyltransferase	230	25703	7.01	1	Golgi apparatus;Endoplasmic reticulum membrane;Rough endoplasmic reticulum;Endoplasmic reticulum;Perinuclear region;Multivesicular body	Leber congenital amaurosis 14	Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938). Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity).	NA	Belongs to the H-rev107 family.	Cofactor metabolism; retinol metabolism.;Retinol metabolism;Vitamin digestion and absorption;The canonical retinoid cycle in rods (twilight vision);Retinoid metabolism and transport;Retinoid cycle disease events	PE1	4
+NX_O95238	SAM pointed domain-containing Ets transcription factor	335	37518	5.89	0	Nucleoplasm;Nucleolus;Nucleus	NA	May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.	NA	Belongs to the ETS family.	NA	PE1	6
+NX_O95239	Chromosome-associated kinesin KIF4A	1232	139881	5.99	0	Nucleus matrix;Spindle;Midbody;Chromosome	Mental retardation, X-linked 100	Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.	MHC class II antigen presentation;Kinesins;Recycling pathway of L1;COPI-dependent Golgi-to-ER retrograde traffic	PE1	X
+NX_O95243	Methyl-CpG-binding domain protein 4	580	66051	9.01	0	Nucleus speckle;Nucleus	NA	Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	NA	NA	Base excision repair;Displacement of DNA glycosylase by APEX1;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine	PE1	3
+NX_O95248	Myotubularin-related protein 5	1868	208443	6.46	0	Cytoplasm;Perinuclear region;Nucleus	Charcot-Marie-Tooth disease 4B3	Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location (PubMed:12668758). May function as a guanine nucleotide exchange factor (GEF) activating RAB28 (PubMed:20937701). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701). Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts (PubMed:9537414).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Synthesis of PIPs at the ER membrane;RAB GEFs exchange GTP for GDP on RABs	PE1	22
+NX_O95249	Golgi SNAP receptor complex member 1	250	28613	9.46	1	Golgi apparatus membrane	NA	Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.	NA	Belongs to the GOSR1 family.	SNARE interactions in vesicular transport;Intra-Golgi traffic;COPI-mediated anterograde transport	PE1	17
+NX_O95251	Histone acetyltransferase KAT7	611	70642	9.01	0	Nucleoplasm;Cytosol;Nucleus	NA	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.	Autoacetylation at Lys-432 is required for proper function.;Ubiquitinated at Lys-338, leading to proteasomal degradation.;Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-85 and Thr-88 by CDK1 (PubMed:18250300). Phosphorylated by MAP2K1, which accelerates its degradation (By similarity).	Belongs to the MYST (SAS/MOZ) family.	HATs acetylate histones	PE1	17
+NX_O95255	Multidrug resistance-associated protein 6	1503	164906	8.82	17	Basolateral cell membrane;Endoplasmic reticulum membrane;Cell membrane	Arterial calcification of infancy, generalized, 2;Pseudoxanthoma elasticum	May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).;Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.	NA	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.	ABC transporters;ABC-family proteins mediated transport;Defective ABCC6 causes pseudoxanthoma elasticum (PXE)	PE1	16
+NX_O95256	Interleukin-18 receptor accessory protein	599	68310	8.67	1	Cell membrane	NA	Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).	N-glycosylated.	Belongs to the interleukin-1 receptor family.	Cytokine-cytokine receptor interaction;Interleukin-18 signaling	PE1	2
+NX_O95257	Growth arrest and DNA damage-inducible protein GADD45 gamma	159	17121	4.26	0	NA	NA	Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.	NA	Belongs to the GADD45 family.	MAPK signaling pathway;Cell cycle;p53 signaling pathway	PE1	9
+NX_O95258	Brain mitochondrial carrier protein 1	325	36202	9.66	6	Mitochondrion inner membrane;Mitochondrion	NA	Participates in the mitochondrial proton leak measured in brain mitochondria.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	The fatty acid cycling model;The proton buffering model	PE1	X
+NX_O95259	Potassium voltage-gated channel subfamily H member 1	989	111423	7.52	6	Presynaptic cell membrane;Cell membrane;Perikaryon;Nucleus inner membrane;Postsynaptic density;Early endosome membrane;Cytoplasmic vesicle;Axon;Dendrite	Zimmermann-Laband syndrome 1;Temple-Baraitser syndrome	Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).	Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6 (PubMed:24587194).	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily.	Voltage gated Potassium channels	PE1	1
+NX_O95260	Arginyl-tRNA--protein transferase 1	518	59090	8.17	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).	NA	Belongs to the R-transferase family.	NA	PE1	10
+NX_O95263	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	885	98979	6.35	0	Nucleoplasm;Cytosol	Primary pigmented nodular adrenocortical disease 3;Striatal degeneration, autosomal dominant 1	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.;Purine metabolism;G alpha (s) signalling events	PE1	5
+NX_O95264	5-hydroxytryptamine receptor 3B	441	50292	5.15	4	Cell membrane	NA	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.	N-glycosylation required for membrane localization.	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.	Neurotransmitter receptors and postsynaptic signal transmission	PE1	11
+NX_O95267	RAS guanyl-releasing protein 1	797	90402	8.2	0	Cytosol;Endoplasmic reticulum membrane;Cell membrane;Golgi apparatus membrane	Systemic lupus erythematosus	Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).	NA	Belongs to the RASGRP family.	MAPK signaling pathway;T cell receptor signaling pathway;FCERI mediated NF-kB activation;RAF/MAP kinase cascade;Effects of PIP2 hydrolysis;Activation of RAS in B cells;Integrin alphaIIb beta3 signaling;Rap1 signalling	PE1	15
+NX_O95271	Poly [ADP-ribose] polymerase tankyrase-1	1327	142039	6.58	0	Cytoplasm;Nuclear pore complex;Nucleus membrane;Nucleoplasm;Spindle pole;Centrosome;Telomere;Golgi apparatus membrane	NA	Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245).	ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.;Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation.;Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis.	NA	Degradation of AXIN;TCF dependent signaling in response to WNT;XAV939 inhibits tankyrase, stabilizing AXIN;Ub-specific processing proteases;Regulation of PTEN stability and activity	PE1	8
+NX_O95273	Cyclin-D1-binding protein 1	360	40262	4.71	0	Nucleoplasm;Cytoplasm;Nucleus	NA	May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.	Phosphorylated.	Belongs to the CCNDBP1 family.	NA	PE1	15
+NX_O95274	Ly6/PLAUR domain-containing protein 3	346	35971	8.05	0	Endoplasmic reticulum;Cytoplasmic vesicle;Cell membrane	NA	Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.	N-glycosylated and O-glycosylated.	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	19
+NX_O95278	Laforin	331	37158	6.19	0	Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Nucleoplasm;Nucleus	Epilepsy, progressive myoclonic 2	Has phosphatase activity (in vitro).;Does not bind to glycogen (PubMed:18617530). Lacks phosphatase activity and might function as a dominant-negative regulator for the phosphatase activity of isoform 1 and isoform 7 (PubMed:18617530, PubMed:22036712).;Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901, PubMed:23922729, PubMed:26231210, PubMed:25538239, PubMed:25544560). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928, PubMed:11220751, PubMed:11739371, PubMed:14532330, PubMed:16971387, PubMed:18617530, PubMed:22036712, PubMed:23922729, PubMed:14722920). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin (PubMed:23922729). Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062).	Polyubiquitinated by NHLRC1/malin.;Phosphorylation on Ser-25 by AMPK affects the phosphatase activity of the enzyme and its ability to homodimerize and interact with NHLRC1, PPP1R3C or PRKAA2.	Belongs to the protein-tyrosine phosphatase family.	Glycogen synthesis;Myoclonic epilepsy of Lafora	PE1	6
+NX_O95279	Potassium channel subfamily K member 5	499	55130	6.3	4	Membrane;Nucleoplasm	NA	PH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.	NA	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Protein digestion and absorption;Phase 4 - resting membrane potential	PE1	6
+NX_O95292	Vesicle-associated membrane protein-associated protein B/C	243	27228	6.85	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	Amyotrophic lateral sclerosis 8;Spinal muscular atrophy, proximal, adult, autosomal dominant	Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.	NA	Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.	Sphingolipid de novo biosynthesis	PE1	20
+NX_O95294	RasGAP-activating-like protein 1	804	90016	6.09	0	Cytosol;Cell junction;Cell membrane	NA	Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003).	NA	NA	Regulation of RAS by GAPs;Signaling by RAS mutants	PE1	12
+NX_O95295	SNARE-associated protein Snapin	136	14874	9.35	0	Golgi apparatus;Lysosome membrane;Nucleolus;Membrane;Synaptic vesicle membrane;Golgi apparatus membrane;Cytosol;Perinuclear region	NA	Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).	Phosphorylated by CSNK1D/CK1 (By similarity). Phosphorylated by PKD, phosphorylation controls SNAPIN protein stability.	Belongs to the SNAPIN family.	Golgi Associated Vesicle Biogenesis	PE1	1
+NX_O95297	Myelin protein zero-like protein 1	269	29082	8.85	1	Membrane;Cytoplasmic vesicle;Cell membrane	NA	But not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.;Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases.;Seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA.	Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro).;N-glycosylated. N-glycosylation is required for concanavalin A binding (PubMed:30392906).	Belongs to the myelin P0 protein family.	Cell adhesion molecules (CAMs)	PE1	1
+NX_O95298	NADH dehydrogenase [ubiquinone] 1 subunit C2	119	14188	9.04	1	Cytoplasm;Mitochondrion inner membrane	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFC2 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis;Neutrophil degranulation	PE1	11
+NX_O95299	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	355	40751	8.67	0	Mitochondrion matrix;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 22	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	Phosphorylation at Ser-250 by PINK1 is required for the binding and/or reduction of the complex I substrate ubiquinone.	Belongs to the complex I NDUFA10 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	2
+NX_O95302	Peptidyl-prolyl cis-trans isomerase FKBP9	570	63084	4.91	0	Endoplasmic reticulum	NA	PPIases accelerate the folding of proteins during protein synthesis.	Phosphorylated.	NA	Association of TriC/CCT with target proteins during biosynthesis	PE1	7
+NX_O95319	CUGBP Elav-like family member 2	508	54285	8.98	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoskeleton	NA	RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233).	NA	Belongs to the CELF/BRUNOL family.	NA	PE1	10
+NX_O95336	6-phosphogluconolactonase	258	27547	5.7	0	Nucleoplasm;Cytoplasm;Cytosol	NA	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.	NA	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.;Pentose phosphate pathway;Metabolic pathways;Pentose phosphate pathway	PE1	19
+NX_O95340	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	614	69501	8.18	0	Mitochondrion	Brachyolmia type 4 with mild epiphyseal and metaphyseal changes	Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have an important role in skeletogenesis during postnatal growth (By similarity).	NA	In the N-terminal section; belongs to the APS kinase family.;In the C-terminal section; belongs to the sulfate adenylyltransferase family.	Sulfur metabolism; sulfate assimilation.;Purine metabolism;Selenocompound metabolism;Sulfur metabolism;Metabolic pathways;Transport and synthesis of PAPS;Defective PAPSS2 causes SEMD-PA;Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	PE1	10
+NX_O95342	Bile salt export pump	1321	146407	6.17	12	Membrane;Nucleoplasm;Cytosol;Cell membrane	Cholestasis, benign recurrent intrahepatic, 2;Cholestasis, progressive familial intrahepatic, 2	Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner (PubMed:16332456). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456).	NA	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.	ABC transporters;Bile secretion;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Recycling of bile acids and salts;Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2	PE1	2
+NX_O95343	Homeobox protein SIX3	332	35487	8.95	0	Nucleoplasm;Nucleus	Schizencephaly;Holoprosencephaly 2	Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway.	NA	Belongs to the SIX/Sine oculis homeobox family.	NA	PE1	2
+NX_O95347	Structural maintenance of chromosomes protein 2	1197	135656	8.54	0	Cytoplasm;Nucleolus;Chromosome;Nucleoplasm;Nucleus	NA	Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.	NA	Belongs to the SMC family. SMC2 subfamily.	Condensation of Prophase Chromosomes;Condensation of Prometaphase Chromosomes	PE1	9
+NX_O95352	Ubiquitin-like modifier-activating enzyme ATG7	703	77960	5.85	0	Cytoplasm;Cell membrane;Nucleoplasm;Preautophagosomal structure;Cytosol	NA	E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity).	Acetylated by EP300.	Belongs to the ATG7 family.	Regulation of autophagy;Antigen processing: Ubiquitination & Proteasome degradation;Macroautophagy;Neutrophil degranulation;Signaling by BRAF and RAF fusions	PE1	3
+NX_O95359	Transforming acidic coiled-coil-containing protein 2	2948	309427	4.71	0	Cytoplasm;Cell membrane;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.	Phosphorylated by TTK; which is required for localization in centrosome.	Belongs to the TACC family.	NA	PE1	10
+NX_O95361	Tripartite motif-containing protein 16	564	63955	5.34	0	Cytoplasm	NA	E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.	Phosphorylated by ULK1.;Auto-ubiquitinates via its B-Boxes.	Belongs to the TRIM/RBCC family.	NA	PE1	17
+NX_O95363	Phenylalanine--tRNA ligase, mitochondrial	451	52357	6.99	0	Mitochondrion matrix;Mitochondrion;Cell membrane	Spastic paraplegia 77, autosomal recessive;Combined oxidative phosphorylation deficiency 14	Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.	NA	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	6
+NX_O95365	Zinc finger and BTB domain-containing protein 7A	584	61439	4.98	0	Nucleoplasm;Nucleus	NA	Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149).	Sumoylated. Undergoes sumoylation with SUMO1 that may regulate its transcriptional activity.	NA	NA	PE1	19
+NX_O95371	Olfactory receptor 2C1	312	34412	8.96	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	16
+NX_O95372	Acyl-protein thioesterase 2	231	24737	6.74	0	Cytoplasm	NA	Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (By similarity).	NA	Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	Glycerophospholipid metabolism;L1CAM interactions	PE1	1
+NX_O95373	Importin-7	1038	119517	4.7	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	(Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev.;Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.	NA	Belongs to the importin beta family.	NA	PE1	11
+NX_O95376	E3 ubiquitin-protein ligase ARIH2	493	57819	5.4	0	Nucleoplasm;Cytoplasm;Nucleus	NA	E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006).	Ubiquitinated. Ubiquitination promotes proteasomal degradation.	Belongs to the RBR family. Ariadne subfamily.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination & Proteasome degradation	PE1	3
+NX_O95377	Gap junction beta-5 protein	273	31088	8.53	4	Gap junction;Cell membrane	NA	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Beta-type (group I) subfamily.	Gap junction assembly	PE2	1
+NX_O95379	Tumor necrosis factor alpha-induced protein 8	198	23003	7.75	0	Cytoplasm;Nucleoplasm	NA	Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.	NA	Belongs to the TNFAIP8 family.	PI Metabolism	PE1	5
+NX_O95382	Mitogen-activated protein kinase kinase kinase 6	1288	142596	6.7	0	Nucleoplasm;Cytosol;Cell membrane;Cytoskeleton	NA	Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway	PE1	1
+NX_O95388	WNT1-inducible-signaling pathway protein 1	367	40331	6.84	0	Cytosol;Secreted	NA	Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.	NA	Belongs to the CCN family.	NA	PE1	8
+NX_O95389	Cellular communication network factor 6	354	39293	8.87	0	Endoplasmic reticulum;Mitochondrion;Secreted	Progressive pseudorheumatoid arthropathy of childhood	Plays a role in mitochondrial electron transport and mitochondrial respiration (PubMed:27252383). Through its regulation of the mitochondrial function may play a role in normal postnatal skeletal growth and cartilage homeostasis (PubMed:27252383, PubMed:10471507).	NA	Belongs to the CCN family.	NA	PE1	6
+NX_O95390	Growth/differentiation factor 11	407	45091	8.18	0	Cytoplasmic vesicle;Secreted	NA	Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).	Synthesized as large precursor molecule that undergoes proteolytic cleavage. The mature C-terminal portion of the molecule is bound non-covalently to its N-terminal propeptide rendering it inactive. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.	Belongs to the TGF-beta family.	NA	PE1	12
+NX_O95391	Pre-mRNA-splicing factor SLU7	586	68387	6.69	0	Cytoplasm;Nucleoplasm;Nucleus speckle;Nucleus	NA	Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154). Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.	NA	Belongs to the SLU7 family.	Spliceosome;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	5
+NX_O95393	Bone morphogenetic protein 10	424	48047	4.89	0	Secreted	NA	Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.	NA	Belongs to the TGF-beta family.	Signaling by BMP;Molecules associated with elastic fibres	PE1	2
+NX_O95394	Phosphoacetylglucosamine mutase	542	59852	5.84	0	Nucleoplasm;Cytosol	Immunodeficiency 23	Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.	NA	Belongs to the phosphohexose mutase family.	Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.;Amino sugar and nucleotide sugar metabolism;Synthesis of UDP-N-acetyl-glucosamine	PE1	6
+NX_O95395	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3	438	50864	8.53	1	Golgi apparatus;Cytoplasmic vesicle;Golgi apparatus membrane	NA	Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.	N-glycosylated.	Belongs to the glycosyltransferase 14 family.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	15
+NX_O95396	Adenylyltransferase and sulfurtransferase MOCS3	460	49669	5.85	0	Cytoplasm	NA	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.	NA	In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.;Cofactor biosynthesis; molybdopterin biosynthesis.;Sulfur relay system;Molybdenum cofactor biosynthesis	PE1	20
+NX_O95397	Putative protein PLEKHA9	391	43539	5.03	0	NA	NA	NA	NA	NA	NA	PE5	12
+NX_O95398	Rap guanine nucleotide exchange factor 3	923	103751	7.28	0	Endomembrane system;Cytosol	NA	Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.	NA	NA	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Integrin alphaIIb beta3 signaling;Regulation of insulin secretion;Rap1 signalling	PE1	12
+NX_O95399	Urotensin-2	124	14296	7.67	0	Secreted	NA	Highly potent vasoconstrictor.	NA	Belongs to the urotensin-2 family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	1
+NX_O95400	CD2 antigen cytoplasmic tail-binding protein 2	341	37646	4.49	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.	NA	NA	mRNA Splicing - Major Pathway	PE1	16
+NX_O95402	Mediator of RNA polymerase II transcription subunit 26	600	65446	9.27	0	Nucleoplasm;Cytosol;Nucleus;Cytoplasmic vesicle	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 26 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	19
+NX_O95405	Zinc finger FYVE domain-containing protein 9	1425	156403	4.89	0	Early endosome membrane;Cytoplasm;Cytosol;Cytoplasmic vesicle	NA	Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.	NA	NA	Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;SMAD2/3 Phosphorylation Motif Mutants in Cancer;TGFBR1 KD Mutants in Cancer	PE1	1
+NX_O95406	Protein cornichon homolog 1	144	16699	5.39	3	Cytoplasmic vesicle;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Involved in the selective transport and maturation of TGF-alpha family proteins.	NA	Belongs to the cornichon family.	COPII-mediated vesicle transport;Cargo concentration in the ER	PE1	14
+NX_O95407	Tumor necrosis factor receptor superfamily member 6B	300	32680	8.68	0	Secreted	NA	Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.	NA	NA	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	20
+NX_O95409	Zinc finger protein ZIC 2	532	55006	8.68	0	Cytoplasm;Nucleus	Holoprosencephaly 5	Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.	Ubiquitinated by RNF180, leading to its degradation.;Phosphorylated.	Belongs to the GLI C2H2-type zinc-finger protein family.	NA	PE1	13
+NX_O95411	TGFB1-induced anti-apoptotic factor 1	115	12414	8.35	0	Nucleus	NA	Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.	NA	NA	NA	PE1	17
+NX_O95415	Brain protein I3	125	13645	8.69	2	Lysosome membrane	NA	Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055).	NA	Belongs to the BRI3 family.	Neutrophil degranulation	PE1	7
+NX_O95416	Transcription factor SOX-14	240	26485	9.68	0	Nucleus	NA	Acts as a negative regulator of transcription.	NA	NA	NA	PE1	3
+NX_O95424	Dexamethasone-induced protein	95	10429	3.61	0	Cytoplasm;Cytosol;Nucleus speckle	NA	NA	NA	Belongs to the DEXI family.	NA	PE2	16
+NX_O95425	Supervillin	2214	247746	6.55	0	Cleavage furrow;Invadopodium;Cell membrane;Podosome;Cytosol;Midbody;Cytoskeleton	NA	Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420).;May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity).	NA	Belongs to the villin/gelsolin family.	NA	PE1	10
+NX_O95427	GPI ethanolamine phosphate transferase 1	931	105810	8.82	15	Cytosol;Endoplasmic reticulum membrane;Cell membrane	Multiple congenital anomalies-hypotonia-seizures syndrome 1	Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation.	NA	Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	18
+NX_O95428	Papilin	1278	137700	6.45	0	Nucleoplasm;Secreted	NA	NA	NA	Belongs to the papilin family.	NA	PE1	14
+NX_O95429	BAG family molecular chaperone regulator 4	457	49594	5.02	0	Cytoplasm	NA	Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.	NA	NA	Regulation of HSF1-mediated heat shock response;Signaling by FGFR1 in disease;TNF signaling;Signaling by plasma membrane FGFR1 fusions	PE1	8
+NX_O95433	Activator of 90 kDa heat shock protein ATPase homolog 1	338	38274	5.41	0	Endoplasmic reticulum;Cytosol	NA	Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).	Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1.	Belongs to the AHA1 family.	NA	PE1	14
+NX_O95436	Sodium-dependent phosphate transport protein 2B	690	75759	8.54	8	Golgi apparatus;Cell membrane;Membrane;Nucleoplasm;Cytosol	Pulmonary alveolar microlithiasis	May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.	NA	Belongs to the SLC34A transporter family.	Mineral absorption;Type II Na+/Pi cotransporters;Surfactant metabolism;Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM);Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)	PE1	4
+NX_O95445	Apolipoprotein M	188	21253	5.66	0	Golgi apparatus;Secreted;Cell membrane	NA	Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.	NA	Belongs to the calycin superfamily. Lipocalin family. Highly divergent.	Retinoid metabolism and transport	PE1	6
+NX_O95447	Lebercilin-like protein	670	76505	9.51	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the LCA5 family.	NA	PE1	21
+NX_O95450	A disintegrin and metalloproteinase with thrombospondin motifs 2	1211	134755	6.76	0	Cytoplasmic vesicle;Extracellular matrix;Cell membrane	Ehlers-Danlos syndrome, dermatosparaxis type	Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (PubMed:31152061).	The precursor is cleaved by a furin endopeptidase.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	O-glycosylation of TSR domain-containing proteins;Collagen biosynthesis and modifying enzymes;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	5
+NX_O95452	Gap junction beta-6 protein	261	30387	8.81	4	Cell junction;Gap junction;Cell membrane	Deafness, autosomal recessive, 1B;Ectodermal dysplasia 2, Clouston type;Deafness, autosomal dominant, 3B	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Beta-type (group I) subfamily.	Gap junction assembly	PE1	13
+NX_O95453	Poly(A)-specific ribonuclease PARN	639	73451	5.86	0	Cytoplasm;Nucleolus;Nucleus speckle;Nucleus	Dyskeratosis congenita, autosomal recessive, 6;Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 4	3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:25049417, PubMed:22442037).	Phosphorylation by MAPKAPK2, preventing GADD45A mRNA degradation after genotoxic stress.	Belongs to the CAF1 family.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;Deadenylation of mRNA;KSRP (KHSRP) binds and destabilizes mRNA	PE1	16
+NX_O95455	dTDP-D-glucose 4,6-dehydratase	350	40214	6.15	0	Nucleoplasm;Cytosol;Nucleolus	Catel-Manzke syndrome	NA	NA	Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	Metabolic pathways	PE1	13
+NX_O95456	Proteasome assembly chaperone 1	288	32854	6.88	0	Golgi apparatus;Cytoplasm;Endoplasmic reticulum;Nucleoplasm;Cytosol	NA	Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.	Degraded by the proteasome upon completion of 20S proteasome maturation.	Belongs to the PSMG1 family.	NA	PE1	21
+NX_O95460	Matrilin-4	622	68487	5.73	0	Secreted	NA	Major component of the extracellular matrix of cartilage.	NA	NA	ECM proteoglycans	PE1	20
+NX_O95461	LARGE xylosyl- and glucuronyltransferase 1	756	88066	7.89	1	Golgi apparatus membrane	Muscular dystrophy-dystroglycanopathy congenital with mental retardation B6;Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A6	Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699).	NA	In the N-terminal section; belongs to the glycosyltransferase 8 family.;In the C-terminal section; belongs to the glycosyltransferase 49 family.	Protein modification; protein glycosylation.;O-linked glycosylation;Defective LARGE causes MDDGA6 and MDDGB6	PE1	22
+NX_O95466	Formin-like protein 1	1100	121854	5.56	0	Cytoplasm;Cell cortex;Cell membrane;Bleb;Phagosome;Cytosol	NA	May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.	Myristoylation mediates membrane localization and blebbing.	Belongs to the formin homology family.	RHO GTPases Activate Formins	PE1	17
+NX_O95467	Neuroendocrine secretory protein 55	245	28029	5.37	0	Secreted;Secretory vesicle	ACTH-independent macronodular adrenal hyperplasia 1;Pseudohypoparathyroidism 1B;GNAS hyperfunction	NA	Binds keratan sulfate chains.;May be proteolytically processed to give rise to a number of active peptides.	Belongs to the NESP55 family.	Calcium signaling pathway;Vascular smooth muscle contraction;Gap junction;Glutamatergic synapse;Dopaminergic synapse;Long-term depression;Taste transduction;GnRH signaling pathway;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Vasopressin-regulated water reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;Vibrio cholerae infection;Chagas disease (American trypanosomiasis);Amoebiasis;Dilated cardiomyopathy	PE1	20
+NX_O95470	Sphingosine-1-phosphate lyase 1	568	63524	9.24	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	Nephrotic syndrome 14	Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity).	NA	Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis	PE1	10
+NX_O95471	Claudin-7	211	22418	8.91	4	Cell membrane;Basolateral cell membrane;Cell junction;Tight junction;Cytoplasmic vesicle	NA	Plays a major role in tight junction-specific obliteration of the intercellular space.	Phosphorylated.	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	17
+NX_O95473	Synaptogyrin-4	234	25820	7.64	4	Membrane;Golgi apparatus	NA	NA	NA	Belongs to the synaptogyrin family.	NA	PE1	19
+NX_O95475	Homeobox protein SIX6	246	27687	9.49	0	Nucleoplasm;Nucleus	Optic disk anomalies with retinal and/or macular dystrophy	May be involved in eye development.	NA	Belongs to the SIX/Sine oculis homeobox family.	NA	PE1	14
+NX_O95476	CTD nuclear envelope phosphatase 1	244	28377	9.78	1	Endoplasmic reticulum membrane;Nucleus membrane;Lipid droplet	NA	Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.	NA	Belongs to the dullard family.	Depolymerisation of the Nuclear Lamina	PE1	17
+NX_O95477	Phospholipid-transporting ATPase ABCA1	2261	254302	6.43	15	Cell membrane;Membrane;Nucleoplasm;Endosome;Cytoplasmic vesicle	High density lipoprotein deficiency 2;High density lipoprotein deficiency 1	Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Thereby, participates to phospholipids transfer to apoliproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981).	Phosphorylation on Ser-2054 regulates phospholipid efflux.;Palmitoylation by DHHC8 is essential for membrane localization.	Belongs to the ABC transporter superfamily. ABCA family.	ABC transporters;Fat digestion and absorption;PPARA activates gene expression;Defective ABCA1 causes Tangier disease;HDL assembly	PE1	9
+NX_O95478	Ribosome biogenesis protein NSA2 homolog	260	30065	10.28	0	Nucleoplasm;Nucleolus;Nucleus	NA	Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).	NA	Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.	NA	PE1	5
+NX_O95479	GDH/6PGL endoplasmic bifunctional protein	791	88893	6.84	0	Cytosol;Endoplasmic reticulum lumen	Cortisone reductase deficiency 1	Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.	NA	In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.;In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.	Pentose phosphate pathway;Metabolic pathways	PE1	1
+NX_O95484	Claudin-9	217	22848	6.54	4	Cytoplasmic vesicle;Tight junction;Cell junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.;(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	16
+NX_O95486	Protein transport protein Sec24A	1093	119749	7.58	0	Endoplasmic reticulum membrane;Nucleolus;COPII-coated vesicle membrane;Cytoplasmic vesicle;Cytosol	NA	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:20427317, PubMed:17499046, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).	NA	Belongs to the SEC23/SEC24 family. SEC24 subfamily.	Protein processing in endoplasmic reticulum;MHC class II antigen presentation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;Cargo concentration in the ER	PE1	5
+NX_O95487	Protein transport protein Sec24B	1268	137418	6.19	0	Endoplasmic reticulum membrane;Nucleoplasm;COPII-coated vesicle membrane;Cytoplasmic vesicle;Cytosol	NA	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).	NA	Belongs to the SEC23/SEC24 family. SEC24 subfamily.	Protein processing in endoplasmic reticulum;MHC class II antigen presentation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;Cargo concentration in the ER	PE1	4
+NX_O95490	Adhesion G protein-coupled receptor L2	1459	163349	6.02	7	Membrane;Cell junction;Cell membrane	NA	Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.	Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	1
+NX_O95497	Pantetheinase	513	57012	5.32	0	Cell membrane	NA	Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.	NA	Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.	Pantothenate and CoA biosynthesis;Vitamin B5 (pantothenate) metabolism;Neutrophil degranulation;Post-translational modification: synthesis of GPI-anchored proteins	PE1	6
+NX_O95498	Vascular non-inflammatory molecule 2	520	58503	6.07	0	Cell membrane	NA	Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.	NA	Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.	Pantothenate and CoA biosynthesis;Vitamin B5 (pantothenate) metabolism;Post-translational modification: synthesis of GPI-anchored proteins	PE1	6
+NX_O95500	Claudin-14	239	25699	8.94	4	Cytoplasmic vesicle;Tight junction;Cell membrane	Deafness, autosomal recessive, 29	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	21
+NX_O95502	Neuronal pentraxin receptor	500	52846	5.82	1	Membrane;Nucleoplasm;Cytosol;Cell membrane	NA	May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.	Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing KLHL2.	NA	NA	PE1	22
+NX_O95503	Chromobox protein homolog 6	412	43898	10.02	0	Nucleoplasm;Mitochondrion;Nucleus;Chromosome	NA	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity).	NA	NA	Oxidative Stress Induced Senescence;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription	PE1	22
+NX_O95521	PRAME family member 1	474	55149	8.88	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_O95522	PRAME family member 12	483	54633	6.11	0	Nucleoplasm	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_O95528	Solute carrier family 2, facilitated glucose transporter member 10	541	56911	8.9	12	Nucleoplasm;Endomembrane system;Perinuclear region;Cytoplasmic vesicle	Arterial tortuosity syndrome	Facilitative glucose transporter required for the development of the cardiovascular system.	NA	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Cellular hexose transport;Defective SLC2A10 causes arterial tortuosity syndrome (ATS)	PE1	20
+NX_O95544	NAD kinase	446	49228	6.03	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the NAD kinase family.	Nicotinate and nicotinamide metabolism;Metabolic pathways;Nicotinate metabolism	PE1	1
+NX_O95551	Tyrosyl-DNA phosphodiesterase 2	362	40930	5.02	0	Cytoplasm;Nucleolus;Nucleoplasm;PML body;Nucleus	Spinocerebellar ataxia, autosomal recessive, 23	DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:27099339, PubMed:27060144). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation.;(Microbial infection) Also acts as a 5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA.	Ubiquitinated by TRAF6.	Belongs to the CCR4/nocturin family.	Nonhomologous End-Joining (NHEJ)	PE1	6
+NX_O95561	Uncharacterized protein C1orf105	183	21209	9.86	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_O95562	Vesicle transport protein SFT2B	160	17779	9.34	4	Membrane	NA	May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.	NA	Belongs to the SFT2 family.	NA	PE1	1
+NX_O95563	Mitochondrial pyruvate carrier 2	127	14279	10.44	3	Mitochondrion inner membrane;Mitochondrion	NA	Mediates the uptake of pyruvate into mitochondria.	NA	Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.	Pyruvate metabolism	PE1	1
+NX_O95567	Uncharacterized protein C22orf31	290	32655	10.06	0	NA	NA	NA	NA	NA	NA	PE2	22
+NX_O95568	Histidine protein methyltransferase 1 homolog	372	42148	6.29	0	Nucleoplasm;Cytosol	NA	Probable histidine methyltransferase.	NA	Belongs to the methyltransferase superfamily. METTL18 family.	NA	PE1	1
+NX_O95571	Persulfide dioxygenase ETHE1, mitochondrial	254	27873	6.35	0	Cytoplasm;Mitochondrion matrix;Mitochondrion;Nucleus	Ethylmalonic encephalopathy	Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897).	NA	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.	Sulfide oxidation to sulfate	PE1	19
+NX_O95573	Long-chain-fatty-acid--CoA ligase 3	720	80420	8.65	1	Microsome membrane;Mitochondrion outer membrane;Endoplasmic reticulum membrane;Lipid droplet;Peroxisome membrane;Nucleolus	NA	Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Fatty acid metabolism;Metabolic pathways;PPAR signaling pathway;Peroxisome;Adipocytokine signaling pathway;Synthesis of very long-chain fatty acyl-CoAs;Intracellular metabolism of fatty acids regulates insulin secretion	PE1	2
+NX_O95600	Krueppel-like factor 8	359	39314	7.19	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).	Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location.	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	X
+NX_O95602	DNA-directed RNA polymerase I subunit RPA1	1720	194811	6.61	0	Nucleoplasm;Nucleolus;Cytoskeleton	Acrofacial dysostosis, Cincinnati type	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).	NA	Belongs to the RNA polymerase beta' chain family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;B-WICH complex positively regulates rRNA expression	PE1	2
+NX_O95613	Pericentrin	3336	378037	5.4	0	Centrosome	Microcephalic osteodysplastic primordial dwarfism 2	Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.	Cleaved during mitotis which leads to removal of CDK5RAP2 from the centrosome and promotes centriole disengagement and subsequent centriole separation (PubMed:22722493, PubMed:25503564). The C-terminal fragment is rapidly degraded following cleavage (PubMed:22722493).	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	21
+NX_O95619	YEATS domain-containing protein 4	227	26499	8.4	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.	NA	NA	HATs acetylate histones;Activation of the TFAP2 (AP-2) family of transcription factors	PE1	12
+NX_O95620	tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like	317	35816	7.04	0	Cytosol	NA	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.	NA	Belongs to the Dus family. Dus4 subfamily.	NA	PE1	7
+NX_O95622	Adenylate cyclase type 5	1261	138908	6.9	12	Cilium;Cytoskeleton;Cell membrane	Dyskinesia, familial, with facial myokymia	Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569).	Phosphorylated by RAF1.	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Chemokine signaling pathway;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;HTLV-I infection;Dilated cardiomyopathy;G alpha (i) signalling events;G alpha (s) signalling events;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (z) signalling events;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway	PE1	3
+NX_O95625	Zinc finger and BTB domain-containing protein 11	1053	119384	8.93	0	Nucleoplasm;Nucleolus	Intellectual developmental disorder, autosomal recessive 69	May be involved in transcriptional regulation.	NA	NA	NA	PE1	3
+NX_O95626	Acidic leucine-rich nuclear phosphoprotein 32 family member D	131	14806	4.98	0	NA	NA	NA	NA	Belongs to the ANP32 family.	NA	PE1	12
+NX_O95628	CCR4-NOT transcription complex subunit 4	575	63510	6.58	0	Cytoplasm;Nucleus	NA	Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292).	Autoubiquitinated.	NA	Protein modification; protein ubiquitination.;RNA degradation;Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	7
+NX_O95630	STAM-binding protein	424	48077	5.89	0	Cytoplasm;Cell membrane;Early endosome;Membrane;Nucleoplasm;Cytosol;Nucleus	Microcephaly-capillary malformation syndrome	Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.	Phosphorylated after BMP type I receptor activation.;Ubiquitinated by SMURF2 in the presence of RNF11.	Belongs to the peptidase M67C family.	Endocytosis;Metalloprotease DUBs	PE1	2
+NX_O95631	Netrin-1	604	67748	9.1	0	Cytoplasm;Secreted	Mirror movements 4	Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335).	NA	NA	Axon guidance;DSCAM interactions;Netrin-1 signaling;Role of second messengers in netrin-1 signaling;Netrin mediated repulsion signals;DCC mediated attractive signaling;Regulation of commissural axon pathfinding by SLIT and ROBO	PE1	17
+NX_O95633	Follistatin-related protein 3	263	27663	6.37	0	Nucleoplasm;Secreted;Nucleus	NA	Or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.;Or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma.	NA	NA	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Antagonism of Activin by Follistatin;Post-translational protein phosphorylation	PE1	19
+NX_O95639	Cleavage and polyadenylation specificity factor subunit 4	269	30255	8.68	0	Nucleoplasm;Nucleus	NA	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).	NA	Belongs to the CPSF4/YTH1 family.	Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;Inhibition of Host mRNA Processing and RNA Silencing;tRNA processing in the nucleus;RNA Polymerase II Transcription Termination	PE1	7
+NX_O95644	Nuclear factor of activated T-cells, cytoplasmic 1	943	101243	6.52	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity).	Phosphorylated by NFATC-kinase and GSK3B; phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1.;NFATC1 is phosphorylated by PIM1 (Phosphoserine:PTM-0253);NFATC1 is phosphorylated by DYRK1A (Phosphoserine:PTM-0253);NFATC1 is phosphorylated by GSK3B (Phosphoserine:PTM-0253);NFATC1 is phosphorylated by DYRK2	NA	Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Osteoclast differentiation;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;HTLV-I infection;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation;Calcineurin activates NFAT	PE1	18
+NX_O95661	GTP-binding protein Di-Ras3	229	25861	9.46	0	Cytosol;Nucleus membrane;Cell membrane	NA	NA	NA	Belongs to the small GTPase superfamily. Di-Ras family.	NA	PE1	1
+NX_O95665	Neurotensin receptor type 2	410	45385	9.5	7	Cell membrane	NA	Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	2
+NX_O95670	V-type proton ATPase subunit G 2	118	13604	10.26	0	Melanosome	NA	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	NA	Belongs to the V-ATPase G subunit family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	6
+NX_O95671	Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein	621	68857	5.71	0	Cytosol	NA	Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable).	NA	In the N-terminal section; belongs to the Maf family. YhdE subfamily.;In the C-terminal section; belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.	NA	PE1	X
+NX_O95672	Endothelin-converting enzyme-like 1	775	87791	6.58	1	Membrane;Nucleoplasm;Nucleolus;Nucleus membrane	Arthrogryposis, distal, 5D	May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.	N-glycosylated.	Belongs to the peptidase M13 family.	NA	PE1	2
+NX_O95674	Phosphatidate cytidylyltransferase 2	445	51418	6.64	6	Endoplasmic reticulum;Cytosol;Mitochondrion inner membrane	NA	Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.	NA	Belongs to the CDS family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PG	PE1	20
+NX_O95677	Eyes absent homolog 4	639	69505	5.04	0	Cytoplasm;Nucleoplasm;Nucleus	Deafness, autosomal dominant, 10;Cardiomyopathy, dilated 1J	Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).	NA	Belongs to the HAD-like hydrolase superfamily. EYA family.	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	PE1	6
+NX_O95678	Keratin, type II cytoskeletal 75	551	59560	7.6	0	Cytosol;Cell membrane	Loose anagen hair syndrome	Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_O95684	FGFR1 oncogene partner	399	43065	4.67	0	Centrosome;Cilium basal body;Centriole	NA	Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385).	NA	Belongs to the FGFR1OP family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Signaling by FGFR1 in disease;Signaling by cytosolic FGFR1 fusion mutants;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	6
+NX_O95685	Protein phosphatase 1 regulatory subunit 3D	299	32559	8.44	0	Cytoplasmic vesicle;Mitochondrion;Nucleolus	NA	Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.	NA	NA	Insulin signaling pathway	PE1	20
+NX_O95696	Bromodomain-containing protein 1	1058	119520	8.91	0	Nucleus speckle;Nucleus	NA	Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.	NA	NA	HATs acetylate histones;Regulation of TP53 Activity through Acetylation	PE1	22
+NX_O95704	Amyloid-beta A4 precursor protein-binding family B member 3	486	52585	5.97	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	May modulate the internalization of amyloid-beta precursor protein.	NA	NA	NA	PE1	5
+NX_O95707	Ribonuclease P protein subunit p29	220	25425	10.08	0	Nucleolus	NA	Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.	NA	Belongs to the eukaryotic/archaeal RNase P protein component 1 family.	Ribosome biogenesis in eukaryotes;RNA transport;tRNA processing in the nucleus	PE1	19
+NX_O95711	Lymphocyte antigen 86	162	17906	5.83	0	Extracellular space	NA	May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).	NA	NA	Toll Like Receptor 4 (TLR4) Cascade	PE1	6
+NX_O95714	E3 ubiquitin-protein ligase HERC2	4834	527228	5.88	0	Cytoplasm;Centriole;Cell membrane;Cytosol;Nucleus	Mental retardation, autosomal recessive 38	E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).	Phosphorylation at Thr-4827 is required for interaction with RNF8.;Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs), promoting the interaction with RNF8.	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination & Proteasome degradation;SUMOylation of DNA damage response and repair proteins;G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ)	PE1	15
+NX_O95715	C-X-C motif chemokine 14	111	13078	10.1	0	Golgi apparatus;Secreted	NA	Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.	Ubiquitinated, followed by degradation by the proteasome.	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway	PE1	5
+NX_O95716	Ras-related protein Rab-3D	219	24267	4.76	0	Cytoplasmic vesicle;Cell membrane	NA	Protein transport. Probably involved in regulated exocytosis (By similarity).	Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and CHML.	Belongs to the small GTPase superfamily. Rab family.	Pancreatic secretion;Neutrophil degranulation;RAB geranylgeranylation	PE1	19
+NX_O95718	Steroid hormone receptor ERR2	433	48054	8.09	0	Cytoplasm;Nucleus;Chromosome	Deafness, autosomal recessive, 35	Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Positively regulates ESR1 transcriptional activity upon E2 stimulation.;Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity).	Acetylated by PCAF/KAT2 (in vitro).	Belongs to the nuclear hormone receptor family. NR3 subfamily.	Nuclear Receptor transcription pathway	PE1	14
+NX_O95721	Synaptosomal-associated protein 29	258	28970	5.56	0	Autophagosome membrane;Cytoplasm;Nucleoplasm;Golgi apparatus membrane;Cilium membrane;Cytosol	Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome	SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions.	NA	Belongs to the SNAP-25 family.	SNARE interactions in vesicular transport;Intra-Golgi traffic;Neutrophil degranulation	PE1	22
+NX_O95727	Cytotoxic and regulatory T-cell molecule	393	44641	6.37	1	Membrane	NA	Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.	NA	Belongs to the nectin family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	11
+NX_O95741	Copine-6	557	61991	5.32	0	Cytoplasm;Clathrin-coated vesicle;Cell membrane;Perikaryon;Endosome;Dendrite	NA	Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).	NA	Belongs to the copine family.	Glycerophospholipid biosynthesis	PE1	14
+NX_O95744	Putative postmeiotic segregation increased 2-like protein 2	297	32669	9.52	0	NA	NA	NA	NA	Belongs to the DNA mismatch repair MutL/HexB family.	NA	PE5	7
+NX_O95747	Serine/threonine-protein kinase OSR1	527	58022	6.03	0	Cytoplasm;Cytosol	NA	Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202).	Autophosphorylated.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	NA	PE1	3
+NX_O95749	Geranylgeranyl pyrophosphate synthase	300	34871	5.78	0	Cytoplasm	NA	Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.	NA	Belongs to the FPP/GGPP synthase family.	Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.;Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.;Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.;Terpenoid backbone biosynthesis;Metabolic pathways;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	1
+NX_O95750	Fibroblast growth factor 19	216	24003	6.55	0	Secreted	NA	Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;FGFR4 ligand binding and activation;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade, FGFR4;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR4 signaling;betaKlotho-mediated ligand binding;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	11
+NX_O95751	Protein LDOC1	146	16968	4.11	0	Nucleoplasm;Nucleolus;Nucleus	NA	May have an important role in the development and/or progression of some cancers.	NA	Belongs to the LDOC1 family.	NA	PE1	X
+NX_O95754	Semaphorin-4F	770	83511	6.5	1	Cell membrane;Perikaryon;Endoplasmic reticulum;Nucleoplasm;Centrosome;Postsynaptic density;Dendrite	NA	Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity).	NA	Belongs to the semaphorin family.	Axon guidance	PE1	2
+NX_O95755	Ras-related protein Rab-36	333	36322	8.05	0	Cytoplasmic vesicle;Golgi apparatus membrane	NA	Protein transport. Probably involved in vesicular traffic (By similarity).	NA	Belongs to the small GTPase superfamily. Rab family.	Intra-Golgi traffic;RAB geranylgeranylation	PE1	22
+NX_O95757	Heat shock 70 kDa protein 4L	839	94512	5.63	0	Cytoplasm;Cytosol;Centrosome;Nucleus	NA	Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.	NA	Belongs to the heat shock protein 70 family.	Protein processing in endoplasmic reticulum;Regulation of HSF1-mediated heat shock response	PE1	4
+NX_O95758	Polypyrimidine tract-binding protein 3	552	59690	9.13	0	Nucleoplasm	NA	RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U).	NA	NA	NA	PE1	9
+NX_O95759	TBC1 domain family member 8	1140	130835	5.32	0	Nucleoplasm	NA	May act as a GTPase-activating protein for Rab family protein(s).	NA	NA	NA	PE1	2
+NX_O95760	Interleukin-33	270	30759	8.89	0	Nucleus;Secreted;Secretory vesicle;Chromosome	NA	Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).;In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).	The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full length protein. May also be proteolytically processed by calpains (PubMed:19596270). Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation (PubMed:19559631). In vitro proteolytic cleavage by CASP1 was reported (PubMed:16286016) but could not be confirmed in vivo (PubMed:19465481) suggesting that IL33 is probably not a direct substrate for that caspase.	Belongs to the IL-1 family. Highly divergent.	Cytosolic DNA-sensing pathway;Influenza A;PIP3 activates AKT signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Ub-specific processing proteases;Interleukin-33 signaling	PE1	9
+NX_O95772	STARD3 N-terminal-like protein	234	26655	4.75	4	Cytoplasmic vesicle;Late endosome membrane	NA	Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263).	NA	Belongs to the STARD3 family.	Pregnenolone biosynthesis	PE1	7
+NX_O95777	U6 snRNA-associated Sm-like protein LSm8	96	10403	4.34	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).	NA	Belongs to the snRNP Sm proteins family.	RNA degradation;Spliceosome;mRNA Splicing - Major Pathway	PE1	7
+NX_O95780	Zinc finger protein 682	498	58361	9.22	0	Golgi apparatus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_O95782	AP-2 complex subunit alpha-1	977	107546	6.63	0	Coated pit;Cytoplasmic vesicle;Cell membrane	NA	Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).	AP2A1 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the adaptor complexes large subunit family.	Endocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Huntington's disease;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Retrograde neurotrophin signalling;Recycling pathway of L1;Nef Mediated CD8 Down-regulation;WNT5A-dependent internalization of FZD4;Nef Mediated CD4 Down-regulation;Trafficking of GluR2-containing AMPA receptors;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance	PE1	19
+NX_O95785	Protein Wiz	1651	178674	6.4	0	Midbody;Nucleoplasm;Nucleus	NA	May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_O95786	Probable ATP-dependent RNA helicase DDX58	925	106600	6.03	0	Cytoplasm;Cell membrane;Tight junction;Ruffle membrane;Cytosol;Cytoskeleton	Singleton-Merten syndrome 2	Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.	Sumoylated, probably by MUL1; inhibiting its polyubiquitination.;Phosphorylated in resting cells and dephosphorylated in RNA virus-infected cells. Phosphorylation at Thr-770, Ser-854 and Ser-855 results in inhibition of its activity while dephosphorylation at these sites results in its activation.;(Microbial infection) Deamidated on 'Asn-495' and 'Asn-549' by herpes simplex virus 1 protein UL37. These modifications eliminate DDX58 detection of viral RNA and restriction of viral replication.;ISGylated. Conjugated to ubiquitin-like protein ISG15 upon IFN-beta stimulation. ISGylation negatively regulates its function in antiviral signaling response.;Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. Lys-172 is the critical site for TRIM25-mediated ubiquitination, for MAVS/IPS1 binding and to induce anti-viral signal transduction (PubMed:17392790, PubMed:30193849). Lys-154, Lys-164 and Lys-172 are critical sites for RNF135-mediated and TRIM4-mediated ubiquitination (PubMed:19017631, PubMed:19484123, PubMed:24755855). Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains (PubMed:18636086). Also probably deubiquitinated by USP17L2/USP17 that cleaves 'Lys-48'-and 'Lys-63'-linked ubiquitin chains and positively regulates the receptor (PubMed:20368735). Ubiquitinated at Lys-181 by RNF125, leading to its degradation: ubiquitination takes place upon viral infection and is enhanced 'Lys-63'-linked ubiquitination of the CARD domains, which promote interaction with VCP/p97 and subsequent recruitment of RNF125 (PubMed:17460044, PubMed:26471729). Ubiquitinated at Lys-812 by CBL, leading to its degradation: ubiquitination takes place upon viral infection and involves 'Lys-48'-linked ubiquitination (By similarity).	Belongs to the helicase family. RLR subfamily.	RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Hepatitis C;Measles;Influenza A;Herpes simplex infection;ISG15 antiviral mechanism;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;TRAF3-dependent IRF activation pathway;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Ub-specific processing proteases;Ovarian tumor domain proteases;OAS antiviral response	PE1	9
+NX_O95789	Zinc finger MYM-type protein 6	1325	148089	8.59	0	Nucleoplasm;Nucleus	NA	Plays a role in the regulation of cell morphology and cytoskeletal organization.	NA	NA	NA	PE1	1
+NX_O95793	Double-stranded RNA-binding protein Staufen homolog 1	577	63182	9.46	0	Cytoplasm;Cytosol;Rough endoplasmic reticulum	NA	(Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.;Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.	NA	NA	NA	PE1	20
+NX_O95800	Probable G-protein coupled receptor 75	540	59359	9.28	7	Cell membrane	NA	G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	2
+NX_O95801	Tetratricopeptide repeat protein 4	387	44679	5.43	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	May act as a co-chaperone for HSP90AB1 (PubMed:18320024). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827).	NA	Belongs to the TTC4 family.	NA	PE1	1
+NX_O95803	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3	873	100902	8.21	1	Golgi apparatus membrane	NA	Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.	NA	Belongs to the sulfotransferase 1 family. NDST subfamily.	Glycan metabolism; heparan sulfate biosynthesis.;Glycan metabolism; heparin biosynthesis.;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;HS-GAG biosynthesis	PE2	4
+NX_O95807	Transmembrane protein 50A	157	17400	5.57	4	Cell membrane;Membrane;Endoplasmic reticulum;Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the UPF0220 family.	NA	PE1	1
+NX_O95810	Caveolae-associated protein 2	425	47173	5.14	0	Cytosol;Caveola;Cell membrane	NA	Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).	Phosphorylated on Ser residues.	Belongs to the CAVIN family.	NA	PE1	2
+NX_O95813	Cerberus	267	30084	7.7	0	Secreted	NA	Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).	N-glycosylated.	Belongs to the DAN family.	Wnt signaling pathway;Signaling by BMP;Signaling by NODAL;Regulation of signaling by NODAL	PE1	9
+NX_O95816	BAG family molecular chaperone regulator 2	211	23772	6.25	0	Cytoplasm;Nucleoplasm	NA	Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).	NA	NA	Protein processing in endoplasmic reticulum;Regulation of HSF1-mediated heat shock response	PE1	6
+NX_O95817	BAG family molecular chaperone regulator 3	575	61595	6.46	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	Cardiomyopathy, dilated 1HH;Myopathy, myofibrillar, 6	Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).	NA	NA	Regulation of HSF1-mediated heat shock response	PE1	10
+NX_O95819	Mitogen-activated protein kinase kinase kinase kinase 4	1239	142101	7.09	0	Cytoplasm	NA	Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	MAPK signaling pathway;Oxidative Stress Induced Senescence	PE1	2
+NX_O95822	Malonyl-CoA decarboxylase, mitochondrial	493	55003	9.11	0	Cytoplasm;Mitochondrion matrix;Peroxisome;Peroxisome matrix	Malonyl-CoA decarboxylase deficiency	Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.	Acetylation at Lys-472 activates malonyl-CoA decarboxylase activity. Deacetylation at Lys-472 by SIRT4 represses activity, leading to promote lipogenesis (By similarity).;Interchain disulfide bonds may form in peroxisomes (Potential). Interchain disulfide bonds are not expected to form in the reducing environment of the cytoplasm and mitochondria.	NA	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malonyl-CoA: step 1/1.;beta-Alanine metabolism;Propanoate metabolism;Metabolic pathways;Peroxisome;Beta-oxidation of very long chain fatty acids;Peroxisomal protein import	PE1	16
+NX_O95825	Quinone oxidoreductase-like protein 1	349	38697	5.49	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.	NA	PE1	21
+NX_O95831	Apoptosis-inducing factor 1, mitochondrial	613	66901	9.04	0	Cytoplasm;Mitochondrion intermembrane space;Mitochondrion inner membrane;Perinuclear region;Nucleus	Deafness, X-linked, 5;Combined oxidative phosphorylation deficiency 6;Cowchock syndrome	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. Caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.	Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. Ubiquitination at Lys-255 by XIAP/BIRC4 blocks its ability to bind DNA and induce chromatin degradation, thereby inhibiting its ability to induce cell death.;Under normal conditions, a 54-residue N-terminal segment is first proteolytically removed during or just after translocation into the mitochondrial intermembrane space (IMS) by the mitochondrial processing peptidase (MPP) to form the inner-membrane-anchored mature form (AIFmit). During apoptosis, it is further proteolytically processed at amino-acid position 101 leading to the generation of the mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis in a caspase-independent manner.	Belongs to the FAD-dependent oxidoreductase family.	Glutathione metabolism;Apoptosis	PE1	X
+NX_O95832	Claudin-1	211	22744	8.41	4	Basolateral cell membrane;Tight junction;Cell membrane	Ichthyosis-sclerosing cholangitis neonatal syndrome	(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes (PubMed:17325668, PubMed:20375010). Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed:20375010). Acts as a receptor for dengue virus (PubMed:24074594).;Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Pathogenic Escherichia coli infection;Hepatitis C;Tight junction interactions	PE1	3
+NX_O95833	Chloride intracellular channel protein 3	236	26648	5.99	1	Membrane;Cytoplasm;Nucleus	NA	Can insert into membranes and form chloride ion channels. May participate in cellular growth control.	NA	Belongs to the chloride channel CLIC family.	NA	PE1	9
+NX_O95834	Echinoderm microtubule-associated protein-like 2	649	70679	5.86	0	Cytoplasmic vesicle;Spindle;Cytoskeleton	NA	Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.	NA	Belongs to the WD repeat EMAP family.	NA	PE1	19
+NX_O95835	Serine/threonine-protein kinase LATS1	1130	126870	8.84	0	Nucleoplasm;Centrosome;Cytoplasmic vesicle	NA	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).	Autophosphorylated and phosphorylated during M-phase of the cell cycle. Phosphorylated by STK3/MST2 at Ser-909 and Thr-1079, which results in its activation. Phosphorylation at Ser-464 by NUAK1 and NUAK2 leads to decreased protein level and is required to regulate cellular senescence and cellular ploidy.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Signaling by Hippo	PE1	6
+NX_O95837	Guanine nucleotide-binding protein subunit alpha-14	355	41571	5.81	0	NA	NA	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.	NA	Belongs to the G-alpha family. G(q) subfamily.	Calcium signaling pathway;Chagas disease (American trypanosomiasis);Amoebiasis;G alpha (q) signalling events;ADP signalling through P2Y purinoceptor 1;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion;Acetylcholine regulates insulin secretion	PE1	9
+NX_O95838	Glucagon-like peptide 2 receptor	553	63001	9.1	7	Cell membrane	NA	This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.	NA	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Glucagon-type ligand receptors	PE1	17
+NX_O95841	Angiopoietin-related protein 1	491	56720	8.42	0	Secreted	NA	NA	NA	NA	NA	PE1	1
+NX_O95843	Guanylyl cyclase-activating protein 3	209	23822	4.95	0	Focal adhesion	NA	Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.	NA	NA	Olfactory transduction;Phototransduction;Inactivation, recovery and regulation of the phototransduction cascade	PE1	3
+NX_O95847	Mitochondrial uncoupling protein 4	323	36064	9.15	6	Mitochondrion inner membrane;Mitochondrion	NA	UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	The fatty acid cycling model;The proton buffering model	PE1	6
+NX_O95848	Uridine diphosphate glucose pyrophosphatase NUDT14	222	24118	4.95	0	Cytoplasm;Nucleolus;Cytoskeleton	NA	Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.	NA	Belongs to the Nudix hydrolase family.	Synthesis of dolichyl-phosphate-glucose	PE1	14
+NX_O95857	Tetraspanin-13	204	22147	8.27	4	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	7
+NX_O95858	Tetraspanin-15	294	33165	5.3	4	Nucleoplasm;Cytosol;Late endosome membrane;Cell membrane	NA	Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Promotes ADAM10-mediated cleavage of CDH2 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).	NA	Belongs to the tetraspanin (TM4SF) family.	Amyloid fiber formation	PE1	10
+NX_O95859	Tetraspanin-12	305	35383	5.72	4	Cytoplasmic vesicle;Cell membrane;Cytoskeleton	Vitreoretinopathy, exudative 5	Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.	Palmitoylated; required for interaction with ADAM10. The precise position of palmitoylated residues is unclear and occurs either on Cys-9, Cys-12 and/or Cys-83.	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	7
+NX_O95861	3'(2'),5'-bisphosphate nucleotidase 1	308	33392	5.46	0	Nucleus speckle	NA	Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.	NA	Belongs to the inositol monophosphatase superfamily.	Sulfur metabolism;Metabolic pathways;Cytosolic sulfonation of small molecules	PE1	1
+NX_O95863	Zinc finger protein SNAI1	264	29083	8.97	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.	ADP-ribosylation by PARP1 increases protein half-life and may be involved in TGFB-induced SNAI1 up-regulation.;O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and stabilizes the protein.;Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination. Phosphorylation by CSNK1E, probably at Ser-104, provides the priming site for the subsequent phosphorylation by GSK3B, probably at Ser-100 and Ser-96. Phosphorylation by PAK1 may modulate its transcriptional activity by promoting increased accumulation in the nucleus. Phosphorylation at Ser-11 and Ser-92 positively regulates its functions in induction of EMT and cell survival, respectively. Phosphorylation by LATS2, upon mitotic stress, oncogenic stress or Hippo pathway activation, occurs in the nucleus and promotes nuclear retention and stabilization of total cellular protein level.;Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation. Ubiquitination induced upon interaction with NOTCH1 or TP53/p53 is mediated by MDM2.	Belongs to the snail C2H2-type zinc-finger protein family.	Regulation of PTEN gene transcription	PE1	20
+NX_O95864	Acyl-CoA 6-desaturase	444	52259	8.86	4	Endoplasmic reticulum membrane	NA	Acts as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:12713571). Subsequently, in the biosynthetic pathway of HUFA n-3 series, desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). Desaturates palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum (PubMed:12713571). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity).	NA	Belongs to the fatty acid desaturase type 1 family.	Lipid metabolism; polyunsaturated fatty acid biosynthesis.;alpha-Linolenic acid metabolism;Biosynthesis of unsaturated fatty acids;PPAR signaling pathway;Linoleic acid (LA) metabolism;alpha-linolenic acid (ALA) metabolism	PE1	11
+NX_O95865	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2	285	29644	5.66	0	Cytoplasm;Cytosol;Centriolar satellite;Mitochondrion	NA	Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.	NA	Belongs to the DDAH family.	eNOS activation	PE1	6
+NX_O95866	Megakaryocyte and platelet inhibitory receptor G6b	241	26163	9.68	1	Golgi apparatus;Endoplasmic reticulum;Cytosol;Cell membrane	Thrombocytopenia, anemia, and myelofibrosis	May be the activating counterpart of isoform B.;Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801).;Displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor.	Phosphorylated.;Is O-glycosylated.;All isoforms are N-glycosylated.	NA	GPVI-mediated activation cascade	PE1	6
+NX_O95867	Lymphocyte antigen 6 complex locus protein G6c	125	13821	8.53	0	Cell membrane	NA	NA	N-glycosylated.	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	6
+NX_O95868	Lymphocyte antigen 6 complex locus protein G6d	133	13691	6.56	0	Filopodium;Cell membrane	NA	NA	O-glycosylated.	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	6
+NX_O95870	Phosphatidylserine lipase ABHD16A	558	63243	8.39	2	Membrane	NA	Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914).	NA	Belongs to the AB hydrolase superfamily. ABHD16 family.	NA	PE1	6
+NX_O95872	G patch domain and ankyrin repeat-containing protein 1	356	39314	8.36	0	Endoplasmic reticulum	NA	NA	NA	NA	NA	PE1	6
+NX_O95873	Uncharacterized protein C6orf47	294	31710	5.95	0	Cytosol	NA	NA	NA	NA	NA	PE1	6
+NX_O95876	WD repeat-containing and planar cell polarity effector protein fritz homolog	746	85084	5.97	0	Cell junction;Cilium axoneme;Cilium basal body;Cell membrane	Congenital heart defects, hamartomas of tongue, and polysyndactyly;Bardet-Biedl syndrome 15	Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).	NA	Belongs to the WD repeat fritz family.	NA	PE1	2
+NX_O95881	Thioredoxin domain-containing protein 12	172	19206	5.25	0	Endoplasmic reticulum lumen	NA	Possesses significant protein thiol-disulfide oxidase activity.	NA	NA	Glutathione metabolism	PE1	1
+NX_O95886	Disks large-associated protein 3	979	106040	8.99	0	Postsynaptic density;Synapse;Cell membrane	NA	May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.	NA	Belongs to the SAPAP family.	Neurexins and neuroligins	PE1	1
+NX_O95897	Noelin-2	454	51386	8.06	0	Cytoplasm;Secreted;Membrane;Nucleoplasm;Synapse;Nucleus	NA	Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).	N-glycosylated.	NA	NA	PE1	19
+NX_O95900	Mitochondrial mRNA pseudouridine synthase TRUB2	331	36694	9.12	0	Mitochondrion matrix	NA	Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).	NA	Belongs to the pseudouridine synthase TruB family.	NA	PE1	9
+NX_O95905	Protein ecdysoneless homolog	644	72758	4.75	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).	Phosphorylated predominantly by CK2 on two serine-containing clusters; involved in cell cycle regulation activity.	Belongs to the ECD family.	NA	PE1	10
+NX_O95907	Monocarboxylate transporter 3	504	52319	5.53	12	Focal adhesion;Cell membrane;Cytoskeleton	NA	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	Pyruvate metabolism;Basigin interactions;Proton-coupled monocarboxylate transport	PE1	22
+NX_O95918	Olfactory receptor 2H2	312	34763	8.51	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_O95922	Probable tubulin polyglutamylase TTLL1	423	48988	8.87	0	Mitochondrion;Nucleolus;Cytoskeleton	NA	Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity).	NA	Belongs to the tubulin polyglutamylase family.	Carboxyterminal post-translational modifications of tubulin	PE1	22
+NX_O95925	Eppin	133	15284	8.52	0	Cell surface;Secreted	NA	Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.	NA	NA	Antimicrobial peptides	PE1	20
+NX_O95926	Pre-mRNA-splicing factor SYF2	243	28722	8.38	0	Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346).	NA	Belongs to the SYF2 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	1
+NX_O95931	Chromobox protein homolog 7	251	28341	9.46	0	Nucleoplasm;Cytosol;Nucleus	NA	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.	NA	NA	NA	PE1	22
+NX_O95932	Protein-glutamine gamma-glutamyltransferase 6	706	79312	6.85	0	Cytoplasm	Spinocerebellar ataxia 35	Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.	NA	Belongs to the transglutaminase superfamily. Transglutaminase family.	NA	PE1	20
+NX_O95935	T-box transcription factor TBX18	607	64753	8.98	0	Nucleus	Congenital anomalies of kidney and urinary tract 2	Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area.	NA	NA	NA	PE1	6
+NX_O95936	Eomesodermin homolog	686	72732	6.94	0	Cytoplasmic vesicle;Nucleus	NA	Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.	NA	NA	NA	PE1	3
+NX_O95944	Natural cytotoxicity triggering receptor 2	276	30677	8.15	1	Cell membrane	NA	Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.	NA	Belongs to the natural cytotoxicity receptor (NCR) family.	Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 interactions	PE1	6
+NX_O95947	T-box transcription factor TBX6	436	47045	8.16	0	Nucleoplasm;Nucleus	Spondylocostal dysostosis 5	T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).	NA	NA	NA	PE1	16
+NX_O95948	One cut domain family member 2	504	54303	9.65	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.	NA	Belongs to the CUT homeobox family.	NA	PE1	18
+NX_O95954	Formimidoyltransferase-cyclodeaminase	541	58927	5.58	0	Golgi apparatus;Cytosol;Cell membrane;Centriole	Glutamate formiminotransferase deficiency	Binds and promotes bundling of vimentin filaments originating from the Golgi.;Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.	NA	In the N-terminal section; belongs to the formiminotransferase family.;In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.	Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.;One-carbon metabolism; tetrahydrofolate interconversion.;Histidine metabolism;One carbon pool by folate;Metabolic pathways;Histidine catabolism	PE1	21
+NX_O95965	Integrin beta-like protein 1	494	53921	5.39	0	Secreted	NA	NA	NA	NA	RUNX2 regulates genes involved in cell migration	PE1	13
+NX_O95967	EGF-containing fibulin-like extracellular matrix protein 2	443	49405	4.79	0	Secreted	Cutis laxa, autosomal recessive, 1B	NA	NA	Belongs to the fibulin family.	Molecules associated with elastic fibres	PE1	11
+NX_O95968	Secretoglobin family 1D member 1	90	9898	9.41	0	Secreted	NA	May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.	NA	Belongs to the secretoglobin family. Lipophilin subfamily.	NA	PE1	11
+NX_O95969	Secretoglobin family 1D member 2	90	9925	8.58	0	Secreted	NA	May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.	NA	Belongs to the secretoglobin family. Lipophilin subfamily.	NA	PE1	11
+NX_O95970	Leucine-rich glioma-inactivated protein 1	557	63818	8.5	0	Secreted;Synapse	Epilepsy, familial temporal lobe, 1	Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.	Glycosylated.	NA	LGI-ADAM interactions	PE1	10
+NX_O95971	CD160 antigen	181	19810	6.94	0	Secreted;Cell membrane	NA	CD160 antigen, soluble form: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.;CD160 antigen: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:19109136, PubMed:11978774, PubMed:17307798). Receptor for both classical and non-classical MHC class I molecules (PubMed:9973372, PubMed:12486241). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity).	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	1
+NX_O95972	Bone morphogenetic protein 15	392	45055	9.28	0	Secreted	Ovarian dysgenesis 2;Premature ovarian failure 4	May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.	NA	Belongs to the TGF-beta family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	X
+NX_O95976	Immunoglobulin superfamily member 6	241	27013	8.93	1	Membrane	NA	NA	NA	NA	NA	PE1	16
+NX_O95977	Sphingosine 1-phosphate receptor 4	384	41623	10.04	7	Mitochondrion;Cell membrane	NA	Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Lysosphingolipid and LPA receptors	PE1	19
+NX_O95980	Reversion-inducing cysteine-rich protein with Kazal motifs	971	106457	6.35	0	Cell membrane	NA	Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069).	N-glycosylated.	Belongs to the RECK family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	9
+NX_O95983	Methyl-CpG-binding domain protein 3	291	32844	5.22	0	Nucleoplasm;Nucleus;Chromosome	NA	Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases.	NA	NA	RNA Polymerase I Transcription Initiation;HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;Regulation of PTEN gene transcription	PE1	19
+NX_O95985	DNA topoisomerase 3-beta-1	862	96662	8.47	0	Nucleoplasm	NA	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity.	NA	Belongs to the type IA topoisomerase family.	Homologous recombination;Fanconi anemia pathway	PE1	22
+NX_O95988	T-cell leukemia/lymphoma protein 1B	128	14846	6.84	0	Cytosol	NA	Enhances the phosphorylation and activation of AKT1 and AKT2.	NA	Belongs to the TCL1 family.	NA	PE1	14
+NX_O95989	Diphosphoinositol polyphosphate phosphohydrolase 1	172	19471	5.99	0	Cytoplasm	NA	Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.	NA	Belongs to the Nudix hydrolase family. DIPP subfamily.	Synthesis of pyrophosphates in the cytosol	PE1	6
+NX_O95990	Actin-associated protein FAM107A	144	17455	9.71	0	Nucleus speckle;Focal adhesion;Stress fiber;Synapse;Ruffle membrane;Nucleus	NA	Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580).	NA	Belongs to the FAM107 family.	NA	PE1	3
+NX_O95992	Cholesterol 25-hydroxylase	272	31745	6.77	3	Endoplasmic reticulum membrane	NA	Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.	N-glycosylated.	Belongs to the sterol desaturase family.	Primary bile acid biosynthesis;Synthesis of bile acids and bile salts	PE1	10
+NX_O95994	Anterior gradient protein 2 homolog	175	19979	9.03	0	Endoplasmic reticulum;Secreted	NA	Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).	NA	Belongs to the AGR family.	NA	PE1	7
+NX_O95995	Dynein regulatory complex subunit 4	478	56356	7.72	0	Golgi apparatus;Flagellum axoneme;Cytoplasm;Cell membrane;Cilium;Cilium basal body;Cilium axoneme;Flagellum;Cytosol;Cytoskeleton	Ciliary dyskinesia, primary, 33	Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity).	NA	Belongs to the DRC4 family.	Activation of SMO	PE1	16
+NX_O95996	Adenomatous polyposis coli protein 2	2303	243949	9.08	0	Golgi apparatus;Cytoplasm;Cytosol;Perinuclear region;Midbody;Cytoskeleton	Sotos syndrome 3	Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329).	NA	Belongs to the adenomatous polyposis coli (APC) family.	Wnt signaling pathway;Regulation of actin cytoskeleton;HTLV-I infection;Pathways in cancer;Colorectal cancer;Endometrial cancer;Basal cell carcinoma	PE1	19
+NX_O95997	Securin	202	22024	6.18	0	Cytoplasm;Nucleus	NA	Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.	Phosphorylated at Ser-165 by CDK1 during mitosis.;Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10.;Phosphorylated in vitro by ds-DNA kinase.	Belongs to the securin family.	Cell cycle;Oocyte meiosis;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Separation of Sister Chromatids	PE1	5
+NX_O95998	Interleukin-18-binding protein	194	21099	6.99	0	Endoplasmic reticulum;Secreted	NA	Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.	N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.	NA	Interleukin-18 signaling;Interleukin-37 signaling	PE1	11
+NX_O95999	B-cell lymphoma/leukemia 10	233	26252	5.57	0	Nucleoplasm;Membrane raft;Perinuclear region	Immunodeficiency 37;Lymphoma, mucosa-associated lymphoid type	Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).	Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.;BCL10 is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254);BCL10 is phosphorylated by IKBKB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	T cell receptor signaling pathway;B cell receptor signaling pathway;Tuberculosis;Activation of NF-kappaB in B cells;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Downstream TCR signaling;E3 ubiquitin ligases ubiquitinate target proteins	PE1	1
+NX_O96000	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	172	20777	8.72	0	Mitochondrion inner membrane	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFB10 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	16
+NX_O96001	Protein phosphatase 1 regulatory subunit 17	155	17866	8.48	0	NA	NA	Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.	Substrate for cGMP-dependent protein kinase.;Substrate for cGMP-dependent protein kinase. Phosphorylated by PRKG1 isoform alpha. Phosphorylation of Thr-68 and Thr-119 is required for its phosphatase activity (By similarity).	NA	Long-term depression	PE1	7
+NX_O96002	Putative transmembrane protein CXorf1	111	13452	9.61	2	Membrane	NA	NA	NA	NA	NA	PE5	X
+NX_O96004	Heart- and neural crest derivatives-expressed protein 1	215	23627	9.69	0	Nucleoplasm;Nucleus membrane;Nucleolus	NA	Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity).	Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity.	NA	NA	PE1	5
+NX_O96005	Cleft lip and palate transmembrane protein 1	669	76097	5.88	5	Golgi apparatus;Cell membrane;Centriolar satellite;Nucleus membrane;Membrane;Endoplasmic reticulum	NA	May play a role in T-cell development.	NA	Belongs to the CLPTM1 family.	NA	PE1	19
+NX_O96006	Zinc finger BED domain-containing protein 1	694	78156	5.79	0	Nucleoplasm;Nucleus;Centrosome;Nucleus membrane	NA	Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity.	NA	NA	SUMOylation of chromatin organization proteins	PE1	X
+NX_O96007	Molybdopterin synthase catalytic subunit	188	20944	5.35	0	Nucleoplasm;Cytosol	Molybdenum cofactor deficiency, complementation group B	Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.	NA	Belongs to the MoaE family. MOCS2B subfamily.	Cofactor biosynthesis; molybdopterin biosynthesis.;Folate biosynthesis;Metabolic pathways;Sulfur relay system;Molybdenum cofactor biosynthesis	PE1	5
+NX_O96008	Mitochondrial import receptor subunit TOM40 homolog	361	37893	6.79	0	Mitochondrion outer membrane;Cytosol;Mitochondrion	NA	Channel-forming protein essential for import of protein precursors into mitochondria.	NA	Belongs to the Tom40 family.	Amyotrophic lateral sclerosis (ALS);Mitochondrial protein import;Pink/Parkin Mediated Mitophagy	PE1	19
+NX_O96009	Napsin-A	420	45387	6.15	0	Secreted	NA	May be involved in processing of pneumocyte surfactant precursors.	NA	Belongs to the peptidase A1 family.	Lysosome;Surfactant metabolism	PE1	19
+NX_O96011	Peroxisomal membrane protein 11B	259	28431	9.91	1	Cytoplasmic vesicle;Peroxisome membrane	Peroxisome biogenesis disorder 14B	Involved in peroxisomal proliferation (PubMed:9792670). May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).	NA	Belongs to the peroxin-11 family.	Peroxisome;Class I peroxisomal membrane protein import	PE1	1
+NX_O96013	Serine/threonine-protein kinase PAK 4	591	64072	9.76	0	Cytoplasm;Cell junction;Cell membrane	NA	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.	Autophosphorylated on serine residues when activated by CDC42/p21 (Ref.31). Phosphorylated on tyrosine residues upon stimulation of FGFR2 (By similarity).;Polyubiquitinated, leading to its proteasomal degradation.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	ErbB signaling pathway;Axon guidance;Focal adhesion;T cell receptor signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;Activation of RAC1	PE1	19
+NX_O96014	Protein Wnt-11	354	39179	9.05	0	Cytosol;Extracellular matrix;Centrosome	NA	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors);PCP/CE pathway;Ca2+ pathway	PE1	11
+NX_O96015	Dynein light chain 4, axonemal	105	12009	5.36	0	Nucleolus;Nucleoplasm;Centrosome;Cilium axoneme;Cytosol	Mirror movements 3	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).	NA	Belongs to the dynein light chain family.	Huntington's disease;Retrograde neurotrophin signalling	PE1	22
+NX_O96017	Serine/threonine-protein kinase Chk2	543	60915	5.65	0	Golgi apparatus;Nucleoplasm;PML body;Nucleus	Prostate cancer;Breast cancer;Osteogenic sarcoma;Li-Fraumeni syndrome 2	Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978).	Phosphorylated. Phosphorylated at Ser-73 by PLK3 in response to DNA damage, promoting phosphorylation at Thr-68 by ATM and the G2/M transition checkpoint. Phosphorylation at Thr-68 induces homodimerization. Autophosphorylates at Thr-383 and Thr-387 in the T-loop/activation segment upon dimerization to become fully active and phosphorylate its substrates like for instance CDC25C. DNA damage-induced autophosphorylation at Ser-379 induces CUL1-mediated ubiquitination and regulates the pro-apoptotic function. Phosphorylation at Ser-456 also regulates ubiquitination. Phosphorylated by PLK4.;Ubiquitinated. CUL1-mediated ubiquitination regulates the pro-apoptotic function. Ubiquitination may also regulate protein stability. Ubiquitinated by RNF8 via 'Lys-48'-linked ubiquitination.;CHEK2 is phosphorylated by PLK4	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily.	Cell cycle;p53 signaling pathway;HTLV-I infection;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;G2/M DNA damage checkpoint;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Stabilization of p53;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation	PE1	22
+NX_O96018	Amyloid-beta A4 precursor protein-binding family A member 3	575	61454	4.83	0	Cytoplasmic vesicle;Perinuclear region	NA	May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.	NA	NA	Neurexins and neuroligins	PE1	19
+NX_O96019	Actin-like protein 6A	429	47461	5.39	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	NA	Belongs to the actin family.	RMTs methylate histone arginines;HATs acetylate histones;DNA Damage Recognition in GG-NER;UCH proteinases;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	3
+NX_O96020	G1/S-specific cyclin-E2	404	46757	7.95	0	Nucleus	NA	Essential for the control of the cell cycle at the late G1 and early S phase.	Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.	Belongs to the cyclin family. Cyclin E subfamily.	Cell cycle;Oocyte meiosis;p53 signaling pathway;Measles;Pathways in cancer;Prostate cancer;Small cell lung cancer;CDK-mediated phosphorylation and removal of Cdc6;DNA Damage/Telomere Stress Induced Senescence;SCF(Skp2)-mediated degradation of p27/p21;G0 and Early G1;Association of TriC/CCT with target proteins during biosynthesis;Cyclin E associated events during G1/S transition;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;p53-Dependent G1 DNA Damage Response;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	PE1	8
+NX_O96024	Beta-1,3-galactosyltransferase 4	378	41537	8.63	1	Golgi apparatus membrane	NA	Involved in GM1/GD1B/GA1 ganglioside biosynthesis.	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Lewis blood group biosynthesis	PE1	6
+NX_O96028	Histone-lysine N-methyltransferase NSD2	1365	152258	9	0	Nucleoplasm;Cytoplasm;Nucleus;Chromosome	NA	Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity.;May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	Lysine degradation;PKMTs methylate histone lysines;G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ)	PE1	4
+NX_O96033	Molybdopterin synthase sulfur carrier subunit	88	9755	4.67	0	Cytosol	Molybdenum cofactor deficiency, complementation group B	Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.	C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.	Belongs to the MoaD family. MOCS2A subfamily.	Cofactor biosynthesis; molybdopterin biosynthesis.;Folate biosynthesis;Metabolic pathways;Sulfur relay system;Molybdenum cofactor biosynthesis	PE1	5
+NX_O97980	Minor histocompatibility protein HB-1	41	4965	4.95	0	NA	NA	Precursor of the histocomplatibility antigen HB-1. More generally, minor histocomplatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocomplatibility antigen in HLA-matched sibling marrow transplants. HB-1 is presented on the cell surface by MHC class I HLA-B44. This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity in B-cell acute lymphoblastic leukemia (B-ALL) after treatment by HLA-identical allogenic bone marrow transplantation (BMT). It induces cell recognition and lysis by CTL. However, HB-1 restricted expression in B-ALL cells and not in normal tissues may allow a specific CTL reactivity against B-ALL without the risk of evoking graft-versus-host disease.	NA	NA	NA	PE1	5
+NX_P00156	Cytochrome b	380	42718	7.83	8	Mitochondrion inner membrane;Mitochondrion	Cardiomyopathy, infantile histiocytoid;Leber hereditary optic neuropathy	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	NA	Belongs to the cytochrome b family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport	PE1	MT
+NX_P00167	Cytochrome b5	134	15330	4.88	1	Microsome membrane;Cytoplasm;Endoplasmic reticulum membrane;Cytoplasmic vesicle;Cytosol	Methemoglobinemia and ambiguous genitalia	Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.	NA	Belongs to the cytochrome b5 family.	Vitamin C (ascorbate) metabolism;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	18
+NX_P00325	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	375	39855	8.63	0	Cytoplasm	NA	Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820).	NA	Belongs to the zinc-containing alcohol dehydrogenase family.	Glycolysis / Gluconeogenesis;Fatty acid metabolism;Tyrosine metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Ethanol oxidation	PE1	4
+NX_P00326	Alcohol dehydrogenase 1C	375	39868	8.63	0	Cytoplasm	NA	NA	NA	Belongs to the zinc-containing alcohol dehydrogenase family.	Glycolysis / Gluconeogenesis;Fatty acid metabolism;Tyrosine metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;RA biosynthesis pathway;Ethanol oxidation	PE1	4
+NX_P00338	L-lactate dehydrogenase A chain	332	36689	8.44	0	Cytoplasm;Cytosol;Cytoplasmic vesicle	Glycogen storage disease 11	NA	ISGylated.	Belongs to the LDH/MDH superfamily. LDH family.	Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.;Glycolysis / Gluconeogenesis;Cysteine and methionine metabolism;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Pyruvate metabolism	PE1	11
+NX_P00352	Retinal dehydrogenase 1	501	54862	6.3	0	Cytosol	NA	Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:19296407, PubMed:26373694, PubMed:25450233).	The N-terminus is blocked most probably by acetylation.	Belongs to the aldehyde dehydrogenase family.	Cofactor metabolism; retinol metabolism.;Retinol metabolism;Metabolic pathways;RA biosynthesis pathway;Fructose catabolism;Ethanol oxidation	PE1	9
+NX_P00367	Glutamate dehydrogenase 1, mitochondrial	558	61398	7.66	0	Mitochondrion matrix	Familial hyperinsulinemic hypoglycemia 6	Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).	ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity (By similarity). Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.	Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;D-Glutamine and D-glutamate metabolism;Nitrogen metabolism;Metabolic pathways;Proximal tubule bicarbonate reclamation;Transcriptional activation of mitochondrial biogenesis;Glutamate and glutamine metabolism	PE1	10
+NX_P00374	Dihydrofolate reductase	187	21453	6.85	0	Cytoplasm;Mitochondrion	Megaloblastic anemia due to dihydrofolate reductase deficiency	Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.	NA	Belongs to the dihydrofolate reductase family.	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.;One carbon pool by folate;Folate biosynthesis;Metabolic pathways;G1/S-Specific Transcription;Metabolism of folate and pterines;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	PE1	5
+NX_P00387	NADH-cytochrome b5 reductase 3	301	34235	7.18	0	Mitochondrion outer membrane;Cytoplasm;Endoplasmic reticulum membrane;Endoplasmic reticulum	Methemoglobinemia CYB5R3-related	Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	NA	Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Amino sugar and nucleotide sugar metabolism;Vitamin C (ascorbate) metabolism;Phase I - Functionalization of compounds;Neutrophil degranulation	PE1	22
+NX_P00390	Glutathione reductase, mitochondrial	522	56257	8.74	0	Cytoplasm;Cytosol;Mitochondrion;Cell membrane	NA	Maintains high levels of reduced glutathione in the cytosol.	NA	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Glutathione metabolism;Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Interconversion of nucleotide di- and triphosphates;Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	PE1	8
+NX_P00395	Cytochrome c oxidase subunit 1	513	57041	6.19	12	Mitochondrion inner membrane;Mitochondrion	Leber hereditary optic neuropathy;Deafness, sensorineural, mitochondrial;Recurrent myoglobinuria mitochondrial;Colorectal cancer;Mitochondrial complex IV deficiency	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	NA	Belongs to the heme-copper respiratory oxidase family.	Energy metabolism; oxidative phosphorylation.;Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	MT
+NX_P00403	Cytochrome c oxidase subunit 2	227	25565	4.67	2	Mitochondrion inner membrane	Mitochondrial complex IV deficiency	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.	NA	Belongs to the cytochrome c oxidase subunit 2 family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	MT
+NX_P00414	Cytochrome c oxidase subunit 3	261	29951	6.78	7	Mitochondrion inner membrane	Recurrent myoglobinuria mitochondrial;Leber hereditary optic neuropathy;Mitochondrial complex IV deficiency	Subunits I, II and III form the functional core of the enzyme complex.	NA	Belongs to the cytochrome c oxidase subunit 3 family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	MT
+NX_P00439	Phenylalanine-4-hydroxylase	452	51862	6.15	0	Endoplasmic reticulum;Cytoplasmic vesicle	Non-phenylketonuria hyperphenylalaninemia;Phenylketonuria;Hyperphenylalaninemia	Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine.	Phosphorylation at Ser-16 increases basal activity and facilitates activation by the substrate phenylalanine.	Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.;Phenylalanine metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis;Metabolic pathways;Phenylketonuria;Phenylalanine metabolism	PE1	12
+NX_P00441	Superoxide dismutase [Cu-Zn]	154	15936	5.7	0	Cytoplasm;Mitochondrion;Cell membrane;Nucleoplasm;Cytosol;Nucleus	Amyotrophic lateral sclerosis 1	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.	The ditryptophan cross-link at Trp-33 is responsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required.;Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.;Palmitoylation helps nuclear targeting and decreases catalytic activity.;Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.	Belongs to the Cu-Zn superoxide dismutase family.	Peroxisome;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Prion diseases;Detoxification of Reactive Oxygen Species;Platelet degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	21
+NX_P00450	Ceruloplasmin	1065	122205	5.44	0	Secreted	Aceruloplasminemia	Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).	NA	Belongs to the multicopper oxidase family.	Porphyrin and chlorophyll metabolism;Iron uptake and transport;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Metal ion SLC transporters;Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages);Defective CP causes aceruloplasminemia (ACERULOP);Post-translational protein phosphorylation	PE1	3
+NX_P00451	Coagulation factor VIII	2351	267009	6.95	0	Extracellular space	Hemophilia A	Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.	Sulfation on Tyr-1699 is essential for binding vWF.	Belongs to the multicopper oxidase family.	Complement and coagulation cascades;Common Pathway of Fibrin Clot Formation;Platelet degranulation;COPII-mediated vesicle transport;Intrinsic Pathway of Fibrin Clot Formation;Cargo concentration in the ER	PE1	X
+NX_P00480	Ornithine carbamoyltransferase, mitochondrial	354	39935	8.75	0	Mitochondrion matrix;Mitochondrion	Ornithine carbamoyltransferase deficiency	NA	Acetylation at Lys-88 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals.	Belongs to the ATCase/OTCase family.	Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1.;Arginine and proline metabolism;Metabolic pathways;Mitochondrial protein import;Urea cycle	PE1	X
+NX_P00488	Coagulation factor XIII A chain	732	83267	5.75	0	Cytoplasm;Secreted	Factor XIII subunit A deficiency	Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.	The activation peptide is released by thrombin.	Belongs to the transglutaminase superfamily. Transglutaminase family.	Complement and coagulation cascades;Common Pathway of Fibrin Clot Formation;Platelet degranulation;Interleukin-4 and Interleukin-13 signaling	PE1	6
+NX_P00491	Purine nucleoside phosphorylase	289	32118	6.45	0	Cytoplasm;Cytosol;Cytoskeleton	Purine nucleoside phosphorylase deficiency	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	NA	Belongs to the PNP/MTAP phosphorylase family.	Purine metabolism; purine nucleoside salvage.;Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Purine catabolism;Purine salvage;Neutrophil degranulation	PE1	14
+NX_P00492	Hypoxanthine-guanine phosphoribosyltransferase	218	24579	6.21	0	Cytoplasm;Cytosol;Nucleus	Gout HPRT-related;Lesch-Nyhan syndrome	Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.	NA	Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.;Purine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Purine salvage	PE1	X
+NX_P00505	Aspartate aminotransferase, mitochondrial	430	47518	9.14	0	Mitochondrion matrix;Cell membrane	NA	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.	NA	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	Alanine, aspartate and glutamate metabolism;Cysteine and methionine metabolism;Arginine and proline metabolism;Tyrosine metabolism;Phenylalanine metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis;Metabolic pathways;Fat digestion and absorption;Gluconeogenesis;Glyoxylate metabolism and glycine degradation;Degradation of cysteine and homocysteine;Glutamate and glutamine metabolism;Aspartate and asparagine metabolism	PE1	16
+NX_P00519	Tyrosine-protein kinase ABL1	1130	122873	8.84	0	Mitochondrion;Nucleus membrane;Nucleoplasm;Nucleus;Cytoskeleton	Leukemia, chronic myeloid;Congenital heart defects and skeletal malformations syndrome	Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity).	Polyubiquitinated. Polyubiquitination of ABL1 leads to degradation.;Acetylated at Lys-711 by EP300 which promotes the cytoplasmic translocation.;Phosphorylation at Tyr-70 by members of the SRC family of kinases disrupts SH3 domain-based autoinhibitory interactions and intermolecular associations, such as that with ABI1, and also enhances kinase activity. Phosphorylation at Tyr-226 and Tyr-393 correlate with increased activity. DNA damage-induced activation of ABL1 requires the function of ATM and Ser-446 phosphorylation (By similarity). Phosphorylation at Ser-569 has been attributed to a CDC2-associated kinase and is coupled to cell division (By similarity). Phosphorylation at Ser-618 and Ser-619 by PAK2 increases binding to CRK and reduces binding to ABI1. Phosphorylation on Thr-735 is required for binding 14-3-3 proteins for cytoplasmic translocation. Phosphorylated by PRKDC (By similarity).;ABL1 is phosphorylated by PDGFRB (Phosphotyrosine:PTM-0255);ABL1 is phosphorylated by CDK1;ABL1 is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);ABL1 is phosphorylated by EPHB2 (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.	ErbB signaling pathway;Cell cycle;Axon guidance;Neurotrophin signaling pathway;Pathogenic Escherichia coli infection;Shigellosis;Pathways in cancer;Chronic myeloid leukemia;Viral myocarditis;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;Factors involved in megakaryocyte development and platelet production;Cyclin D associated events in G1;Role of ABL in ROBO-SLIT signaling;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Single Strand Annealing (SSA);RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX2 regulates osteoblast differentiation;Myogenesis	PE1	9
+NX_P00533	Epidermal growth factor receptor	1210	134277	6.26	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;Cell junction;Secreted;Nucleus membrane;Endosome;Golgi apparatus membrane;Nucleus	Inflammatory skin and bowel disease, neonatal, 2;Lung cancer	May act as an antagonist of EGF action.;(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.;Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance (By similarity).	Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting (PubMed:27153536). Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occurs. Deubiquitination by OTUD7B prevents degradation. Ubiquitinated by RNF115 and RNF126 (By similarity).;Palmitoylated on Cys residues by ZDHHC20. Palmitoylation inhibits internalization after ligand binding, and increases the persistence of tyrosine-phosphorylated EGFR at the cell membrane. Palmitoylation increases the amplitude and duration of EGFR signaling.;Phosphorylated on Tyr residues in response to EGF (PubMed:27153536). Phosphorylation at Ser-695 is partial and occurs only if Thr-693 is phosphorylated. Phosphorylation at Thr-678 and Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1197 is stimulated by methylation at Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT3. Dephosphorylated by PTPN1 and PTPN2.;Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197.	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.	MAPK signaling pathway;ErbB signaling pathway;Calcium signaling pathway;Cytokine-cytokine receptor interaction;Endocytosis;Dorso-ventral axis formation;Focal adhesion;Adherens junction;Gap junction;Regulation of actin cytoskeleton;GnRH signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Hepatitis C;Pathways in cancer;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Signal transduction by L1;EGFR downregulation;Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;EGFR Transactivation by Gastrin;Signaling by EGFR;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;GAB1 signalosome;Constitutive Signaling by EGFRvIII;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;PLCG1 events in ERBB2 signaling;EGFR interacts with phospholipase C-gamma;Inhibition of Signaling by Overexpressed EGFR;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;PTK6 promotes HIF1A stabilization;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;Downregulation of ERBB2 signaling;NOTCH3 Activation and Transmission of Signal to the Nucleus;Extra-nuclear estrogen signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	7
+NX_P00540	Proto-oncogene serine/threonine-protein kinase mos	346	37820	9.15	0	NA	NA	NA	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	MAPK signaling pathway;Oocyte meiosis;Regulation of actin cytoskeleton;Progesterone-mediated oocyte maturation	PE1	8
+NX_P00558	Phosphoglycerate kinase 1	417	44615	8.3	0	Cytoplasm	Phosphoglycerate kinase 1 deficiency	Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959).	NA	Belongs to the phosphoglycerate kinase family.	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.;Glycolysis / Gluconeogenesis;Metabolic pathways;Glycolysis;Gluconeogenesis	PE1	X
+NX_P00568	Adenylate kinase isoenzyme 1	194	21635	8.73	0	Cytoplasm;Cytosol	Hemolytic anemia due to adenylate kinase deficiency	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	NA	Belongs to the adenylate kinase family. AK1 subfamily.	Purine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	9
+NX_P00709	Alpha-lactalbumin	142	16225	4.83	0	Secreted	NA	Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.	NA	Belongs to the glycosyl hydrolase 22 family.	Galactose metabolism;Metabolic pathways;Lactose synthesis	PE1	12
+NX_P00734	Prothrombin	622	70037	5.64	0	Extracellular space	Factor II deficiency;Pregnancy loss, recurrent, 2;Ischemic stroke;Thrombophilia due to thrombin defect	Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.	N-glycosylated. N-glycan heterogeneity at Asn-121: Hex3HexNAc3 (minor), Hex4HexNAc3 (minor) and Hex5HexNAc4 (major). At Asn-143: Hex4HexNAc3 (minor) and Hex5HexNAc4 (major).;The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.	Belongs to the peptidase S1 family.	Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Regulation of actin cytoskeleton;Peptide ligand-binding receptors;G alpha (q) signalling events;Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Thrombin signalling through proteinase activated receptors (PARs);Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Intrinsic Pathway of Fibrin Clot Formation;Platelet Aggregation (Plug Formation);Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins	PE1	11
+NX_P00736	Complement C1r subcomponent	705	80119	5.82	0	Nucleoplasm;Cytosol;Secreted	Ehlers-Danlos syndrome, periodontal type, 1	C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.	Belongs to the peptidase S1 family.	Phagosome;Complement and coagulation cascades;Pertussis;Staphylococcus aureus infection;Systemic lupus erythematosus;Regulation of Complement cascade;Initial triggering of complement;Classical antibody-mediated complement activation	PE1	12
+NX_P00738	Haptoglobin	406	45205	6.13	0	Secreted	Anhaptoglobinemia	The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.;As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.	NA	Belongs to the peptidase S1 family.	Scavenging of heme from plasma;Neutrophil degranulation	PE1	16
+NX_P00739	Haptoglobin-related protein	348	39030	6.63	0	Secreted	NA	Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.	NA	Belongs to the peptidase S1 family.	African trypanosomiasis;Scavenging of heme from plasma	PE1	16
+NX_P00740	Coagulation factor IX	461	51778	5.34	0	Secreted	Hemophilia B;Thrombophilia, X-linked, due to factor IX defect	Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.	Predominantly O-glucosylated at Ser-99 by POGLUT1 in vitro. Xylosylation at this site is minor.;The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.;Activated by factor XIa, which excises the activation peptide (PubMed:9169594, PubMed:1730085). The propeptide can also be removed by snake venom protease (PubMed:20004170, PubMed:20080729).	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Extrinsic Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation;Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins	PE1	X
+NX_P00742	Coagulation factor X	488	54732	5.68	0	Secreted	Factor X deficiency	Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.;N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.;The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.;The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Extrinsic Pathway of Fibrin Clot Formation;Common Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation;Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins	PE1	13
+NX_P00746	Complement factor D	253	27033	7.65	0	Secreted	Complement factor D deficiency	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.	NA	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Staphylococcus aureus infection;Platelet degranulation;Alternative complement activation;Neutrophil degranulation	PE1	19
+NX_P00747	Plasminogen	810	90569	7.04	0	Secreted	Plasminogen deficiency	Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.;Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.	In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.;N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).	Belongs to the peptidase S1 family. Plasminogen subfamily.	Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Staphylococcus aureus infection;Influenza A;Degradation of the extracellular matrix;Signaling by PDGF;Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Activation of Matrix Metalloproteinases;Dissolution of Fibrin Clot	PE1	6
+NX_P00748	Coagulation factor XII	615	67792	8.04	0	Secreted	Factor XII deficiency;Hereditary angioedema 3	Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.	O- and N-glycosylated. The O-linked polysaccharides were not identified, but are probably the mucin type linked to GalNAc.;Factor XII is activated by kallikrein in alpha-factor XIIa, which is further converted by trypsin into beta-factor XIIa. Alpha-factor XIIa is composed of an NH2-terminal heavy chain, called coagulation factor XIIa heavy chain, and a COOH-terminal light chain, called coagulation factor XIIa light chain, connected by a disulfide bond. Beta-factor XIIa is composed of 2 chains linked by a disulfide bond, an N-terminal nonapeptide, called beta-factor XIIa part 1, and coagulation factor XIIa light chain, also known in this context as beta-factor XIIa part 2.	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Intrinsic Pathway of Fibrin Clot Formation	PE1	5
+NX_P00749	Urokinase-type plasminogen activator	431	48507	8.78	0	Secreted	Quebec platelet disorder	Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.	Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Dissolution of Fibrin Clot;Neutrophil degranulation	PE1	10
+NX_P00750	Tissue-type plasminogen activator	562	62917	8.14	0	Cytoskeleton;Extracellular space	NA	Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.	N-glycosylation of Asn-152; the bound oligomannosidic glycan is involved in the interaction with the mannose receptor.;The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.;Characterization of O-linked glycan was studied in Bowes melanoma cell line.;Differential cell-specific N-linked glycosylation gives rise to two glycoforms, type I (glycosylated at Asn-219) and type II (not glycosylated at Asn-219). The single chain type I glycoform is less readily converted into the two-chain form by plasmin, and the two-chain type I glycoform has a lower activity than the two-chain type II glycoform in the presence of fibrin.	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Signaling by PDGF;Dissolution of Fibrin Clot	PE1	8
+NX_P00751	Complement factor B	764	85533	6.67	0	Endoplasmic reticulum;Cell junction;Secreted;Cytoplasmic vesicle	Complement factor B deficiency;Macular degeneration, age-related, 14;Hemolytic uremic syndrome atypical 4	Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.	NA	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Staphylococcus aureus infection;Regulation of Complement cascade;Activation of C3 and C5;Alternative complement activation	PE1	6
+NX_P00797	Renin	406	45057	6.61	0	Membrane;Secreted	Renal tubular dysgenesis;Familial juvenile hyperuricemic nephropathy 2	Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.	NA	Belongs to the peptidase A1 family.	Renin-angiotensin system;Metabolism of Angiotensinogen to Angiotensins	PE1	1
+NX_P00813	Adenosine deaminase	363	40764	5.63	0	Cytoplasm;Cell membrane;Cell junction;Cytoplasmic vesicle lumen;Lysosome;Cytosol	Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency	Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:8452534, PubMed:16670267). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity).	NA	Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	Purine metabolism;Metabolic pathways;Primary immunodeficiency;Purine salvage	PE1	20
+NX_P00846	ATP synthase subunit a	226	24817	10.09	6	Mitochondrion inner membrane	Mitochondrial infantile bilateral striatal necrosis;Neuropathy, ataxia, and retinitis pigmentosa;Ataxia and polyneuropathy, adult-onset;Leber hereditary optic neuropathy;Leigh syndrome;Cardiomyopathy, infantile hypertrophic;Myopathy, lactic acidosis, and sideroblastic anemia 3;Mitochondrial complex V deficiency, mitochondrial 1	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.	NA	Belongs to the ATPase A chain family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	MT
+NX_P00915	Carbonic anhydrase 1	261	28870	6.59	0	Cytoplasm	NA	Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.	NA	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Reversible hydration of carbon dioxide;Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	8
+NX_P00918	Carbonic anhydrase 2	260	29246	6.87	0	Cytoplasm;Cell membrane	Osteopetrosis, autosomal recessive 3	Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.	NA	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Proximal tubule bicarbonate reclamation;Collecting duct acid secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;Reversible hydration of carbon dioxide;Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide	PE1	8
+NX_P00966	Argininosuccinate synthase	412	46530	8.08	0	Nucleoplasm;Cytosol	Citrullinemia 1	One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.	Acetylated by CLOCK in a circadian manner which negatively regulates its enzyme activity. Deacetylated by histone deacetylases.	Belongs to the argininosuccinate synthase family. Type 1 subfamily.	Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1.;Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.;Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;Metabolic pathways;Urea cycle	PE1	9
+NX_P00973	2'-5'-oligoadenylate synthase 1	400	46029	8.51	0	Cytoplasm;Mitochondrion;Microsome;Secreted;Endoplasmic reticulum;Nucleoplasm;Cytosol;Nucleus	NA	Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.	NA	Belongs to the 2-5A synthase family.	Hepatitis C;Measles;Influenza A;Herpes simplex infection;Interferon gamma signaling;Interferon alpha/beta signaling;OAS antiviral response	PE1	12
+NX_P00995	Serine protease inhibitor Kazal-type 1	79	8507	7.54	0	Secreted	Pancreatitis, hereditary;Tropical calcific pancreatitis	In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.;Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity).	NA	NA	NA	PE1	5
+NX_P01008	Antithrombin-III	464	52602	6.32	0	Extracellular space	Antithrombin III deficiency	Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.	Phosphorylated by FAM20C in the extracellular medium.	Belongs to the serpin family.	Complement and coagulation cascades;Common Pathway of Fibrin Clot Formation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Intrinsic Pathway of Fibrin Clot Formation;Post-translational protein phosphorylation	PE1	1
+NX_P01009	Alpha-1-antitrypsin	418	46737	5.37	0	Endoplasmic reticulum;Extracellular matrix;Secreted;Cytoplasmic vesicle	Alpha-1-antitrypsin deficiency	Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.;Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).	Proteolytic processing may yield the truncated form that ranges from Asp-30 to Lys-418.;(Microbial infection) Proteolytically processed by Staphylococcus aureus seryl, cysteinyl, and metallo-proteases.;N-glycosylated. Differential glycosylation produces a number of isoforms. N-linked glycan at Asn-107 is alternatively di-antennary, tri-antennary or tetra-antennary. The glycan at Asn-70 is di-antennary with trace amounts of tri-antennary. Glycan at Asn-271 is exclusively di-antennary. Structure of glycans at Asn-70 and Asn-271 is Hex5HexNAc4. The structure of the antennae is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)[Man(alpha1-3)]Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennae are fucosylated, which forms a Lewis-X determinant.	Belongs to the serpin family.	Complement and coagulation cascades;Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);COPII-mediated vesicle transport;Cargo concentration in the ER;Neutrophil degranulation;Post-translational protein phosphorylation	PE1	14
+NX_P01011	Alpha-1-antichymotrypsin	423	47651	5.33	0	Secreted	NA	Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.	N- and O-glycosylated.	Belongs to the serpin family.	Platelet degranulation;Neutrophil degranulation	PE1	14
+NX_P01019	Angiotensinogen	485	53154	5.87	0	Secreted	Essential hypertension;Renal tubular dysgenesis	Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.;Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.;Angiotensin-3: stimulates aldosterone release.;Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.	The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.;Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.;In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).	Belongs to the serpin family.	Renin-angiotensin system;G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (q) signalling events;PPARA activates gene expression;Metabolism of Angiotensinogen to Angiotensins	PE1	1
+NX_P01023	Alpha-2-macroglobulin	1474	163291	6.03	0	Secreted	NA	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.	NA	Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.	Complement and coagulation cascades;Degradation of the extracellular matrix;Rho GTPase cycle;Platelet degranulation;Intrinsic Pathway of Fibrin Clot Formation;HDL assembly	PE1	12
+NX_P01024	Complement C3	1663	187148	6.02	0	Secreted	Macular degeneration, age-related, 9;Hemolytic uremic syndrome atypical 5;Complement component 3 deficiency	C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.;Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:8376604, PubMed:2909530, PubMed:9059512, PubMed:10432298, PubMed:15833747, PubMed:16333141, PubMed:19615750).;Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.;C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation.	C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by insulin and dietary chylomicrons.;Phosphorylated by FAM20C in the extracellular medium.;(Microbial infection) C3 is cleaved by Staphylococcus aureus aureolysin; this cleavage renders C3a and C3b inactive. C3b is rapidly degraded by host factors CFH and CFI preventing its deposition on the bacterial surface while C3a is further inactivated by aureolysin.	NA	Phagosome;Complement and coagulation cascades;Pertussis;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);Staphylococcus aureus infection;Tuberculosis;Herpes simplex infection;Systemic lupus erythematosus;G alpha (i) signalling events;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Peptide ligand-binding receptors;Regulation of Complement cascade;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Activation of C3 and C5;Alternative complement activation;Neutrophil degranulation;Post-translational protein phosphorylation	PE1	19
+NX_P01031	Complement C5	1676	188305	6.11	0	Secreted	Complement component 5 deficiency	Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.;Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.	NA	NA	Complement and coagulation cascades;Prion diseases;Pertussis;Staphylococcus aureus infection;Herpes simplex infection;Systemic lupus erythematosus;G alpha (i) signalling events;Peptide ligand-binding receptors;Terminal pathway of complement;Regulation of Complement cascade;Activation of C3 and C5	PE1	9
+NX_P01033	Metalloproteinase inhibitor 1	207	23171	8.46	0	Golgi apparatus;Secreted	NA	Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.	N-glycosylated.;The activity of TIMP1 is dependent on the presence of disulfide bonds.	Belongs to the protease inhibitor I35 (TIMP) family.	Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Activation of Matrix Metalloproteinases;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Post-translational protein phosphorylation	PE1	X
+NX_P01034	Cystatin-C	146	15799	9	0	Golgi apparatus;Cytoplasmic vesicle;Secreted	Amyloidosis 6;Macular degeneration, age-related, 11	As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.	The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21.	Belongs to the cystatin family.	Salivary secretion;Amyloid fiber formation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation	PE1	20
+NX_P01036	Cystatin-S	141	16214	4.95	0	Secreted	NA	This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively.	Phosphorylated at both its N- and C-terminal regions.	Belongs to the cystatin family.	Salivary secretion	PE1	20
+NX_P01037	Cystatin-SN	141	16388	6.73	0	Secreted	NA	Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.	NA	Belongs to the cystatin family.	Salivary secretion	PE1	20
+NX_P01040	Cystatin-A	98	11006	5.38	0	Nucleoplasm;Cytosol;Cytoplasm	Peeling skin syndrome 4	This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.	NA	Belongs to the cystatin family.	Formation of the cornified envelope	PE1	3
+NX_P01042	Kininogen-1	644	71957	6.34	0	Extracellular space	High molecular weight kininogen deficiency	(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. Prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.	Bradykinin is released from kininogen by plasma kallikrein.;Phosphorylated by FAM20C in the extracellular medium.;Hydroxylation of Pro-383 occurs prior to the release of bradykinin.;N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.	NA	Complement and coagulation cascades;G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (q) signalling events;Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Intrinsic Pathway of Fibrin Clot Formation;Post-translational protein phosphorylation	PE1	3
+NX_P01100	Proto-oncogene c-Fos	380	40695	4.77	0	Nucleoplasm;Endoplasmic reticulum;Cytosol;Nucleus	NA	Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.	In quiescent cells, the small amount of FOS present is phosphorylated at Tyr-10 and Tyr-30 by SRC. This Tyr-phosphorylated form is cytosolic. In growing cells, dephosphorylated by PTPN2. Dephosphorylation leads to the association with endoplasmic reticulum membranes and activation of phospholipid synthesis.;Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232.;Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation (By similarity).	Belongs to the bZIP family. Fos subfamily.	MAPK signaling pathway;Osteoclast differentiation;Toll-like receptor signaling pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Cholinergic synapse;Dopaminergic synapse;Salmonella infection;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);HTLV-I infection;Herpes simplex infection;Pathways in cancer;Colorectal cancer;Rheumatoid arthritis;Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;Senescence-Associated Secretory Phenotype (SASP);Activation of the AP-1 family of transcription factors;TP53 Regulates Transcription of DNA Repair Genes;Interleukin-4 and Interleukin-13 signaling;Estrogen-dependent gene expression;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	14
+NX_P01106	Myc proto-oncogene protein	439	48804	5.33	0	Nucleoplasm;Nucleolus	Burkitt lymphoma	Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).	Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.;Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus (PubMed:25775507,PubMed:17558397). Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).;MYC is phosphorylated by MAPK7 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MYC is phosphorylated by PRKDC	NA	MAPK signaling pathway;ErbB signaling pathway;Cell cycle;Wnt signaling pathway;TGF-beta signaling pathway;Jak-STAT signaling pathway;HTLV-I infection;Pathways in cancer;Colorectal cancer;Endometrial cancer;Thyroid cancer;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;MAPK6/MAPK4 signaling;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Cyclin E associated events during G1/S transition;Binding of TCF/LEF:CTNNB1 to target gene promoters;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Cyclin A:Cdk2-associated events at S phase entry;Ub-specific processing proteases;TFAP2 (AP-2) family regulates transcription of cell cycle factors;Interleukin-4 and Interleukin-13 signaling;RUNX3 regulates WNT signaling;Transcription of E2F targets under negative control by DREAM complex;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	8
+NX_P01111	GTPase NRas	189	21229	5.01	0	Golgi apparatus membrane;Cell membrane	Thyroid cancer, non-medullary, 2;Noonan syndrome 6;Melanosis, neurocutaneous;Leukemia, juvenile myelomonocytic;Melanocytic nevus syndrome, congenital;Keratinocytic non-epidermolytic nevus;RAS-associated autoimmune leukoproliferative disorder	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).;Palmitoylated by the ZDHHC9-GOLGA7 complex (PubMed:16000296). Depalmitoylated by ABHD17A, ABHD17B and ABHD17C (PubMed:26701913). A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi (PubMed:16000296, PubMed:15705808, PubMed:2661017, PubMed:26701913).;Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.;Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.	Belongs to the small GTPase superfamily. Ras family.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Axon guidance;VEGF signaling pathway;Tight junction;Gap junction;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Long-term depression;Regulation of actin cytoskeleton;Insulin signaling pathway;GnRH signaling pathway;Melanogenesis;Hepatitis C;Pathways in cancer;Renal cell carcinoma;Endometrial cancer;Glioma;Prostate cancer;Thyroid cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;Regulation of RAS by GAPs;RAF/MAP kinase cascade;SHC-mediated cascade:FGFR1;FRS-mediated FGFR1 signaling;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;DAP12 signaling;FCERI mediated MAPK activation;Ras activation upon Ca2+ influx through NMDA receptor;Negative regulation of MAPK pathway;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;GRB2 events in ERBB2 signaling;EGFR Transactivation by Gastrin;RAF activation;MAP2K and MAPK activation;Signaling by SCF-KIT;CD209 (DC-SIGN) signaling;Activation of RAS in B cells;NCAM signaling for neurite out-growth;Insulin receptor signalling cascade;VEGFR2 mediated cell proliferation;p38MAPK events;Tie2 Signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Signalling to RAS;SOS-mediated signalling;Downstream signal transduction;Constitutive Signaling by EGFRvIII;Signaling by FGFR4 in disease;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;SHC-related events triggered by IGF1R;Signaling by FGFR3 point mutants in cancer;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;Signaling by FGFR3 fusions in cancer;Neutrophil degranulation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates RAS signaling;RAS signaling downstream of NF1 loss-of-function variants;Activated NTRK2 signals through RAS;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK3 signals through RAS;Erythropoietin activates RAS;Estrogen-stimulated signaling through PRKCZ;FLT3 Signaling	PE1	1
+NX_P01112	GTPase HRas	189	21298	5.16	0	Cytoplasm;Golgi apparatus;Cell membrane;Nucleoplasm;Golgi apparatus membrane;Cytosol;Perinuclear region;Nucleus	Thyroid cancer, non-medullary, 2;Bladder cancer;Congenital myopathy with excess of muscle spindles;Schimmelpenning-Feuerstein-Mims syndrome;Costello syndrome	Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151).	S-nitrosylated; critical for redox regulation. Important for stimulating guanine nucleotide exchange. No structural perturbation on nitrosylation.;Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.;Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).;Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.;The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation.	Belongs to the small GTPase superfamily. Ras family.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Endocytosis;Axon guidance;VEGF signaling pathway;Focal adhesion;Tight junction;Gap junction;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Long-term depression;Regulation of actin cytoskeleton;Insulin signaling pathway;GnRH signaling pathway;Hepatitis C;HTLV-I infection;Pathways in cancer;Renal cell carcinoma;Endometrial cancer;Glioma;Prostate cancer;Thyroid cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;Regulation of RAS by GAPs;RAF/MAP kinase cascade;SHC-mediated cascade:FGFR1;FRS-mediated FGFR1 signaling;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;EPHB-mediated forward signaling;DAP12 signaling;FCERI mediated MAPK activation;Ras activation upon Ca2+ influx through NMDA receptor;Negative regulation of MAPK pathway;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;GRB2 events in ERBB2 signaling;EGFR Transactivation by Gastrin;RAF activation;MAP2K and MAPK activation;Signaling by SCF-KIT;CD209 (DC-SIGN) signaling;Activation of RAS in B cells;NCAM signaling for neurite out-growth;Insulin receptor signalling cascade;VEGFR2 mediated cell proliferation;p38MAPK events;Tie2 Signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Signalling to RAS;SOS-mediated signalling;Downstream signal transduction;Constitutive Signaling by EGFRvIII;Signaling by FGFR4 in disease;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;SHC-related events triggered by IGF1R;Signaling by FGFR3 point mutants in cancer;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;Signaling by FGFR3 fusions in cancer;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates RAS signaling;RAS signaling downstream of NF1 loss-of-function variants;Activated NTRK2 signals through RAS;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK3 signals through RAS;Erythropoietin activates RAS;Estrogen-stimulated signaling through PRKCZ;FLT3 Signaling	PE1	11
+NX_P01116	GTPase KRas	189	21656	6.33	0	Cytosol;Cell membrane	Cardiofaciocutaneous syndrome 2;Gastric cancer;Leukemia, juvenile myelomonocytic;Leukemia, acute myelogenous;Noonan syndrome 3	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).	Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.;Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).	Belongs to the small GTPase superfamily. Ras family.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Dorso-ventral axis formation;Axon guidance;VEGF signaling pathway;Tight junction;Gap junction;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Long-term depression;Regulation of actin cytoskeleton;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Aldosterone-regulated sodium reabsorption;Hepatitis C;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Thyroid cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;Regulation of RAS by GAPs;RAF/MAP kinase cascade;SHC-mediated cascade:FGFR1;FRS-mediated FGFR1 signaling;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;DAP12 signaling;FCERI mediated MAPK activation;Ras activation upon Ca2+ influx through NMDA receptor;Negative regulation of MAPK pathway;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;GRB2 events in ERBB2 signaling;EGFR Transactivation by Gastrin;RAF activation;MAP2K and MAPK activation;Signaling by SCF-KIT;CD209 (DC-SIGN) signaling;Activation of RAS in B cells;NCAM signaling for neurite out-growth;Insulin receptor signalling cascade;VEGFR2 mediated cell proliferation;p38MAPK events;Tie2 Signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Signalling to RAS;SOS-mediated signalling;Downstream signal transduction;Constitutive Signaling by EGFRvIII;Signaling by FGFR4 in disease;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;SHC-related events triggered by IGF1R;Signaling by FGFR3 point mutants in cancer;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;Signaling by FGFR3 fusions in cancer;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates RAS signaling;RAS signaling downstream of NF1 loss-of-function variants;RUNX3 regulates p14-ARF;Activated NTRK2 signals through RAS;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK3 signals through RAS;Erythropoietin activates RAS;Estrogen-stimulated signaling through PRKCZ;FLT3 Signaling	PE1	12
+NX_P01127	Platelet-derived growth factor subunit B	241	27283	9.39	0	Cytoplasmic vesicle;Secreted	Basal ganglia calcification, idiopathic, 5	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).	NA	Belongs to the PDGF/VEGF growth factor family.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Focal adhesion;Gap junction;Regulation of actin cytoskeleton;HTLV-I infection;Pathways in cancer;Renal cell carcinoma;Glioma;Prostate cancer;Melanoma;RAF/MAP kinase cascade;Signaling by PDGF;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Platelet degranulation;Non-integrin membrane-ECM interactions;Downstream signal transduction;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	22
+NX_P01130	Low-density lipoprotein receptor	860	95376	4.86	1	Golgi apparatus;Cell membrane;Early endosome;Clathrin-coated pit;Late endosome;Lysosome	Familial hypercholesterolemia	(Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.;(Microbial infection) Acts as a receptor for Vesicular stomatitis virus.;(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins.;Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.	Ubiquitinated by MYLIP leading to degradation.;N- and O-glycosylated.	Belongs to the LDLR family.	Endocytosis;Bile secretion;Toxoplasmosis;Hepatitis C;Retinoid metabolism and transport;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;LDL clearance;Chylomicron clearance	PE1	19
+NX_P01133	Pro-epidermal growth factor	1207	133994	5.53	1	Membrane	Hypomagnesemia 4	EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).	O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor).	NA	MAPK signaling pathway;ErbB signaling pathway;Cytokine-cytokine receptor interaction;Endocytosis;Focal adhesion;Gap junction;Regulation of actin cytoskeleton;Hepatitis C;Pathways in cancer;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Non-small cell lung cancer;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;EGFR downregulation;Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Platelet degranulation;Signaling by EGFR;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;GAB1 signalosome;Constitutive Signaling by EGFRvIII;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;PLCG1 events in ERBB2 signaling;EGFR interacts with phospholipase C-gamma;Inhibition of Signaling by Overexpressed EGFR;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;NOTCH3 Activation and Transmission of Signal to the Nucleus;Extra-nuclear estrogen signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	4
+NX_P01135	Protransforming growth factor alpha	160	17006	7.51	1	Cytoplasmic vesicle;Cell membrane;Extracellular space	NA	TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.	NA	NA	ErbB signaling pathway;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Glioma;Prostate cancer;Non-small cell lung cancer;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;EGFR downregulation;Signaling by EGFR;COPII-mediated vesicle transport;GAB1 signalosome;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;EGFR interacts with phospholipase C-gamma;Inhibition of Signaling by Overexpressed EGFR;Cargo concentration in the ER;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;Estrogen-dependent gene expression;Extra-nuclear estrogen signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	2
+NX_P01137	Transforming growth factor beta-1 proprotein	390	44341	8.83	0	Golgi apparatus;Cytosol;Extracellular matrix;Secreted	Inflammatory bowel disease, immunodeficiency, and encephalopathy;Camurati-Engelmann disease	Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.;Latency-associated peptide: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix (PubMed:28117447). Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1 (PubMed:2022183, PubMed:8617200, PubMed:8939931, PubMed:19750484, PubMed:22278742, PubMed:19651619). Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia (Probable). Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:22278742, PubMed:19651619). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1 (PubMed:22278742, PubMed:28117447).;Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix (PubMed:29109152). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus (PubMed:2022183, PubMed:8617200, PubMed:8939931, PubMed:19750484, PubMed:22278742, PubMed:19651619). TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1 (PubMed:22278742, PubMed:28117447). Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (PubMed:20207738). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules' (By similarity). Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner (By similarity). At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development (By similarity). At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292, PubMed:29483653). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292).	Latency-associated peptide: N-glycosylated (PubMed:3162913, PubMed:2493139, PubMed:28117447). Deglycosylation leads to activation of Transforming growth factor beta-1 (TGF-beta-1); mechanisms triggering deglycosylation-driven activation of TGF-beta-1 are however unclear (PubMed:2493139).;Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.	Belongs to the TGF-beta family.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Cell cycle;Endocytosis;TGF-beta signaling pathway;Osteoclast differentiation;Intestinal immune network for IgA production;Leishmaniasis;Chagas disease (American trypanosomiasis);Malaria;Toxoplasmosis;Amoebiasis;Tuberculosis;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Chronic myeloid leukemia;Rheumatoid arthritis;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Syndecan interactions;Cell surface interactions at the vascular wall;Platelet degranulation;ECM proteoglycans;Molecules associated with elastic fibres;Downregulation of TGF-beta receptor signaling;Transcriptional regulation of white adipocyte differentiation;TGF-beta receptor signaling activates SMADs;SMAD2/3 Phosphorylation Motif Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;TGFBR2 MSI Frameshift Mutants in Cancer;Influenza Virus Induced Apoptosis;UCH proteinases;Interleukin-4 and Interleukin-13 signaling;Regulation of RUNX3 expression and activity;RUNX3 regulates CDKN1A transcription;RUNX3 regulates p14-ARF	PE1	19
+NX_P01138	Beta-nerve growth factor	241	26959	9.94	0	Endosome lumen;Secreted	Neuropathy, hereditary sensory and autonomic, 5	Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).	NA	Belongs to the NGF-beta family.	MAPK signaling pathway;Apoptosis;Neurotrophin signaling pathway;Axonal growth stimulation;NRAGE signals death through JNK;p75NTR recruits signalling complexes;Signalling to p38 via RIT and RIN;Retrograde neurotrophin signalling;ARMS-mediated activation;p75NTR negatively regulates cell cycle via SC1;NF-kB is activated and signals survival;NRIF signals cell death from the nucleus;Signalling to RAS;NGF processing;NADE modulates death signalling;Frs2-mediated activation;PI3K/AKT activation;Ceramide signalling;NFG and proNGF binds to p75NTR;PLC-gamma1 signalling;TRKA activation by NGF;Signalling to STAT3	PE1	1
+NX_P01148	Progonadoliberin-1	92	10380	6.1	0	Secreted	Hypogonadotropic hypogonadism 12 with or without anosmia	Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.	NA	Belongs to the GnRH family.	GnRH signaling pathway;G alpha (q) signalling events;Hormone ligand-binding receptors	PE1	8
+NX_P01160	Natriuretic peptides A	153	16708	6.59	0	Secreted	Atrial fibrillation, familial, 6;Atrial standstill 2	Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.	Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.;Cleaved by CORIN upon secretion to produce the functional hormone.	Belongs to the natriuretic peptide family.	YAP1- and WWTR1 (TAZ)-stimulated gene expression;Amyloid fiber formation;Physiological factors	PE1	1
+NX_P01178	Oxytocin-neurophysin 1	125	12722	5.72	0	Secreted	NA	Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed:18174156).;Neurophysin 1 specifically binds oxytocin.	NA	Belongs to the vasopressin/oxytocin family.	G alpha (q) signalling events;Vasopressin-like receptors	PE1	20
+NX_P01185	Vasopressin-neurophysin 2-copeptin	164	17325	5.2	0	Secreted	Diabetes insipidus, neurohypophyseal	Neurophysin 2 specifically binds vasopressin.;Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (PubMed:18174156).	NA	Belongs to the vasopressin/oxytocin family.	Vasopressin-regulated water reabsorption;G alpha (q) signalling events;G alpha (s) signalling events;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Vasopressin regulates renal water homeostasis via Aquaporins;Transport of organic anions;Vasopressin-like receptors;Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	PE1	20
+NX_P01189	Pro-opiomelanocortin	267	29424	7.57	0	Secreted	Obesity;Obesity, early-onset, with adrenal insufficiency and red hair	Met-enkephalin: Endogenous opiate.;Corticotropin: Stimulates the adrenal glands to release cortisol.;Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.;Beta-endorphin: Endogenous orexigenic opiate.;Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.	Specific enzymatic cleavages at paired basic residues yield the different active peptides.;O-glycosylated; reducing sugar is probably N-acetylgalactosamine.	Belongs to the POMC family.	Melanogenesis;Adipocytokine signaling pathway;G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (s) signalling events;Endogenous sterols;G-protein activation;Glucocorticoid biosynthesis;Opioid Signalling;Androgen biosynthesis;Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD);Peptide hormone biosynthesis;Interleukin-4 and Interleukin-13 signaling;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	2
+NX_P01210	Proenkephalin-A	267	30787	5.44	0	Secreted	NA	Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.	The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.	Belongs to the opioid neuropeptide precursor family.	G alpha (i) signalling events;Peptide ligand-binding receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	8
+NX_P01213	Proenkephalin-B	254	28385	6.07	0	Secreted	Spinocerebellar ataxia 23	Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).;Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).;Leumorphin has a typical opiod activity and may have anti-apoptotic effect.	The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.	Belongs to the opioid neuropeptide precursor family.	G alpha (i) signalling events;Peptide ligand-binding receptors;G-protein activation;Opioid Signalling	PE1	20
+NX_P01215	Glycoprotein hormones alpha chain	116	13075	8.54	0	Secreted	NA	Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.	NA	Belongs to the glycoprotein hormones subunit alpha family.	Neuroactive ligand-receptor interaction;GnRH signaling pathway;Autoimmune thyroid disease;G alpha (s) signalling events;Glycoprotein hormones;Reactions specific to the complex N-glycan synthesis pathway;Thyroxine biosynthesis;Hormone ligand-binding receptors;Androgen biosynthesis;Mineralocorticoid biosynthesis;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	PE1	6
+NX_P01222	Thyrotropin subunit beta	138	15639	7.92	0	Secreted	NA	Indispensable for the control of thyroid structure and metabolism.	NA	Belongs to the glycoprotein hormones subunit beta family.	Neuroactive ligand-receptor interaction;Autoimmune thyroid disease;G alpha (s) signalling events;Glycoprotein hormones;Thyroxine biosynthesis;Hormone ligand-binding receptors	PE1	1
+NX_P01225	Follitropin subunit beta	129	14700	6.77	0	Secreted	Hypogonadotropic hypogonadism 24 without anosmia	Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432).	NA	Belongs to the glycoprotein hormones subunit beta family.	Neuroactive ligand-receptor interaction;GnRH signaling pathway;G alpha (s) signalling events;Glycoprotein hormones;Hormone ligand-binding receptors	PE1	11
+NX_P01229	Lutropin subunit beta	141	15345	8	0	Secreted	Hypogonadotropic hypogonadism 23 without anosmia	Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.	NA	Belongs to the glycoprotein hormones subunit beta family.	Neuroactive ligand-receptor interaction;GnRH signaling pathway;G alpha (s) signalling events;Glycoprotein hormones;Reactions specific to the complex N-glycan synthesis pathway;Hormone ligand-binding receptors;Androgen biosynthesis;Mineralocorticoid biosynthesis	PE1	19
+NX_P01236	Prolactin	227	25876	6.5	0	Secreted	NA	Prolactin acts primarily on the mammary gland by promoting lactation.	NA	Belongs to the somatotropin/prolactin family.	Cytokine-cytokine receptor interaction;Neuroactive ligand-receptor interaction;Jak-STAT signaling pathway;Amyloid fiber formation;Prolactin receptor signaling;Growth hormone receptor signaling	PE1	6
+NX_P01241	Somatotropin	217	24847	5.29	0	Secreted	Growth hormone deficiency, isolated, 1A;Kowarski syndrome;Growth hormone deficiency, isolated, 2;Growth hormone deficiency, isolated, 1B	Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.	NA	Belongs to the somatotropin/prolactin family.	Cytokine-cytokine receptor interaction;Neuroactive ligand-receptor interaction;Jak-STAT signaling pathway;Prolactin receptor signaling;Growth hormone receptor signaling;Synthesis, secretion, and deacylation of Ghrelin	PE1	17
+NX_P01242	Growth hormone variant	217	25000	7.59	0	Secreted	NA	Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.	NA	Belongs to the somatotropin/prolactin family.	Cytokine-cytokine receptor interaction;Neuroactive ligand-receptor interaction;Jak-STAT signaling pathway;Prolactin receptor signaling;Growth hormone receptor signaling	PE1	17
+NX_P01258	Calcitonin	141	15467	5.77	0	Secreted	NA	Katacalcin is a potent plasma calcium-lowering peptide.;Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.	NA	Belongs to the calcitonin family.	G alpha (s) signalling events;Amyloid fiber formation;Calcitonin-like ligand receptors	PE1	11
+NX_P01266	Thyroglobulin	2768	304790	5.4	0	Secreted	Thyroid dyshormonogenesis 3;Autoimmune thyroid disease 3	Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).	Sulfated tyrosines are desulfated during iodination.	Belongs to the type-B carboxylesterase/lipase family.	Autoimmune thyroid disease	PE1	8
+NX_P01270	Parathyroid hormone	115	12861	9.72	0	Secreted	Hypoparathyroidism, familial isolated	PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.	NA	Belongs to the parathyroid hormone family.	G alpha (s) signalling events;Class B/2 (Secretin family receptors)	PE1	11
+NX_P01275	Glucagon	180	20909	5.85	0	Endoplasmic reticulum;Cytoplasmic vesicle;Secreted	NA	Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.;Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.;Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.;GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.;GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis.	Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.	Belongs to the glucagon family.	G alpha (q) signalling events;G alpha (s) signalling events;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon signaling in metabolic regulation;Glucagon-type ligand receptors;Synthesis, secretion, and deacylation of Ghrelin	PE1	2
+NX_P01282	VIP peptides	170	19169	6.15	0	Endoplasmic reticulum;Secreted	NA	VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.;PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.	NA	Belongs to the glucagon family.	G alpha (s) signalling events;Glucagon-type ligand receptors	PE1	6
+NX_P01286	Somatoliberin	108	12447	10.54	0	Secreted	NA	GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.	NA	Belongs to the glucagon family.	G alpha (s) signalling events;Glucagon-type ligand receptors	PE1	20
+NX_P01298	Pancreatic prohormone	95	10445	6.71	0	Secreted	NA	The physiological role for the icosapeptide has not yet been elucidated.;Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.	NA	Belongs to the NPY family.	G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	17
+NX_P01303	Pro-neuropeptide Y	97	10851	6.57	0	Golgi apparatus;Secreted	NA	NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.	The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).	Belongs to the NPY family.	Adipocytokine signaling pathway;G alpha (i) signalling events;Peptide ligand-binding receptors;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	7
+NX_P01308	Insulin	110	11981	5.22	0	Secreted	Maturity-onset diabetes of the young 10;Diabetes mellitus, insulin-dependent, 2;Hyperproinsulinemia;Diabetes mellitus, permanent neonatal	Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NA	Belongs to the insulin family.	Oocyte meiosis;Regulation of autophagy;mTOR signaling pathway;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Type II diabetes mellitus;Type I diabetes mellitus;Maturity onset diabetes of the young;Aldosterone-regulated sodium reabsorption;Prostate cancer;Insulin processing;Regulation of gene expression in beta cells;Insulin receptor recycling;Amyloid fiber formation;Synthesis, secretion, and deacylation of Ghrelin;IRS activation;Signal attenuation;Insulin receptor signalling cascade;Signaling by Insulin receptor;Regulation of insulin secretion;COPI-mediated anterograde transport;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	11
+NX_P01344	Insulin-like growth factor II	180	20140	9.5	0	Nucleoplasm;Cytosol;Secreted;Cytoplasmic vesicle	Growth restriction, severe, with distinctive facies;Silver-Russell syndrome	Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.;The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464).	O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99.;Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.	Belongs to the insulin family.	Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	PE1	11
+NX_P01350	Gastrin	101	11394	5.08	0	Secreted	NA	Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.	Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.;Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.	Belongs to the gastrin/cholecystokinin family.	Gastric acid secretion;G alpha (q) signalling events;Gastrin-CREB signalling pathway via PKC and MAPK	PE1	17
+NX_P01374	Lymphotoxin-alpha	205	22297	9.1	0	Membrane;Secreted	Psoriatic arthritis	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.	NA	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;Type I diabetes mellitus;HTLV-I infection;Herpes simplex infection;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;TNFs bind their physiological receptors	PE1	6
+NX_P01375	Tumor necrosis factor	233	25644	6.44	1	Membrane;Secreted;Cell membrane	Psoriatic arthritis	The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.;Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity).	O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.;The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.;The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.	Belongs to the tumor necrosis factor family.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Apoptosis;TGF-beta signaling pathway;Osteoclast differentiation;Antigen processing and presentation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Hematopoietic cell lineage;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Adipocytokine signaling pathway;Type II diabetes mellitus;Type I diabetes mellitus;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Pertussis;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);African trypanosomiasis;Malaria;Toxoplasmosis;Amoebiasis;Tuberculosis;Hepatitis C;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;TNFR2 non-canonical NF-kB pathway;Transcriptional regulation of white adipocyte differentiation;TNFR1-induced proapoptotic signaling;TNF signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling	PE1	6
+NX_P01562	Interferon alpha-1/13	189	21725	5.32	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE1	9
+NX_P01563	Interferon alpha-2	188	21550	6.32	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE1	9
+NX_P01566	Interferon alpha-10	189	21835	5.97	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE1	9
+NX_P01567	Interferon alpha-7	189	22107	6.44	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE1	9
+NX_P01568	Interferon alpha-21	189	21741	6.33	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE1	9
+NX_P01569	Interferon alpha-5	189	21942	5.68	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE1	9
+NX_P01570	Interferon alpha-14	189	22063	6.83	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE1	9
+NX_P01571	Interferon alpha-17	189	21728	5.68	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE1	9
+NX_P01574	Interferon beta	187	22294	8.93	0	Secreted	NA	Has antiviral, antibacterial and anticancer activities.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Osteoclast differentiation;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Chagas disease (American trypanosomiasis);Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Oxidative Stress Induced Senescence;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation;TRAF3-dependent IRF activation pathway	PE1	9
+NX_P01579	Interferon gamma	166	19348	9.5	0	Secreted	Aplastic anemia	Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.	Belongs to the type II (or gamma) interferon family.	Proteasome;Cytokine-cytokine receptor interaction;Regulation of autophagy;TGF-beta signaling pathway;Osteoclast differentiation;Antigen processing and presentation;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;Type I diabetes mellitus;Salmonella infection;Leishmaniasis;Chagas disease (American trypanosomiasis);African trypanosomiasis;Malaria;Toxoplasmosis;Amoebiasis;Tuberculosis;Measles;Influenza A;Interferon gamma signaling;Regulation of IFNG signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	PE1	12
+NX_P01583	Interleukin-1 alpha	271	30607	5.04	0	Secreted	NA	Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.	NA	Belongs to the IL-1 family.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Apoptosis;Osteoclast differentiation;Hematopoietic cell lineage;Type I diabetes mellitus;Prion diseases;Salmonella infection;Pertussis;Leishmaniasis;Tuberculosis;Measles;Influenza A;Rheumatoid arthritis;Graft-versus-host disease;Senescence-Associated Secretory Phenotype (SASP);Interleukin-1 processing;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Interleukin-1 signaling	PE1	2
+NX_P01584	Interleukin-1 beta	269	30748	4.7	0	Extracellular exosome;Cytosol;Secreted;Lysosome	NA	Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).	Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.	Belongs to the IL-1 family.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Apoptosis;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Hematopoietic cell lineage;Type I diabetes mellitus;Alzheimer's disease;Prion diseases;Salmonella infection;Pertussis;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);African trypanosomiasis;Malaria;Amoebiasis;Tuberculosis;CLEC7A/inflammasome pathway;Interleukin-1 processing;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Interleukin-1 signaling	PE1	2
+NX_P01588	Erythropoietin	193	21307	8.3	0	Secreted	Diamond-Blackfan anemia-like;Microvascular complications of diabetes 2;Erythrocytosis, familial, 5	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	NA	Belongs to the EPO/TPO family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Regulation of gene expression by Hypoxia-inducible Factor;Erythropoietin activates RAS;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Signaling by Erythropoietin;Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5	PE1	7
+NX_P01589	Interleukin-2 receptor subunit alpha	272	30819	6.11	1	Membrane	Immunodeficiency 41 with lymphoproliferation and autoimmunity;Diabetes mellitus, insulin-dependent, 10	Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	NA	NA	Cytokine-cytokine receptor interaction;Endocytosis;Jak-STAT signaling pathway;Hematopoietic cell lineage;Measles;HTLV-I infection;RAF/MAP kinase cascade;Interleukin receptor SHC signaling;RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs);Interleukin-2 signaling	PE1	10
+NX_P01591	Immunoglobulin J chain	159	18099	5.12	0	Secreted	NA	Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.	NA	NA	Cell surface interactions at the vascular wall;Scavenging of heme from plasma	PE1	4
+NX_P01593	Immunoglobulin kappa variable 1D-33	117	12848	4.53	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01594	Immunoglobulin kappa variable 1-33	117	12848	4.53	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01597	Immunoglobulin kappa variable 1-39	117	12737	8.91	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01599	Immunoglobulin kappa variable 1-17	117	12779	8.93	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01601	Immunoglobulin kappa variable 1D-16	117	12730	7.62	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01602	Immunoglobulin kappa variable 1-5	117	12782	8.49	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01611	Immunoglobulin kappa variable 1D-12	117	12620	7.69	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01614	Immunoglobulin kappa variable 2D-40	121	13310	4.43	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01615	Immunoglobulin kappa variable 2D-28	120	12957	5.61	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01619	Immunoglobulin kappa variable 3-20	116	12557	4.85	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01624	Immunoglobulin kappa variable 3-15	115	12496	5.14	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01699	Immunoglobulin lambda variable 1-44	117	12201	4.94	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01700	Immunoglobulin lambda variable 1-47	117	12284	5.55	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01701	Immunoglobulin lambda variable 1-51	117	12249	6.5	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01703	Immunoglobulin lambda variable 1-40	118	12302	5.39	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01704	Immunoglobulin lambda variable 2-14	120	12597	6	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01705	Immunoglobulin lambda variable 2-23	113	11893	5.59	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01706	Immunoglobulin lambda variable 2-11	119	12644	6.69	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01709	Immunoglobulin lambda variable 2-8	118	12382	5.59	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01714	Immunoglobulin lambda variable 3-19	112	12042	4.76	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01715	Immunoglobulin lambda variable 3-1	115	12296	4.75	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01717	Immunoglobulin lambda variable 3-25	112	12011	4.37	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01718	Immunoglobulin lambda variable 3-27	113	12165	4.89	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01721	Immunoglobulin lambda variable 6-57	117	12566	4.59	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P01730	T-cell surface glycoprotein CD4	458	51111	9.6	1	Cell membrane	NA	(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).;Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.;Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.	NA	Cell adhesion molecules (CAMs);Antigen processing and presentation;Hematopoietic cell lineage;T cell receptor signaling pathway;Primary immunodeficiency;Vpu mediated degradation of CD4;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling;Alpha-defensins;Nef Mediated CD4 Down-regulation;Binding and entry of HIV virion;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Other interleukin signaling	PE1	12
+NX_P01732	T-cell surface glycoprotein CD8 alpha chain	235	25729	9.64	1	Secreted;Cell membrane	CD8 deficiency, familial	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.	Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.;Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.;O-glycosylated.	NA	Cell adhesion molecules (CAMs);Antigen processing and presentation;Hematopoietic cell lineage;T cell receptor signaling pathway;Primary immunodeficiency;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	2
+NX_P01733	T cell receptor beta variable 12-3	115	12997	5.84	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	7
+NX_P01737	T cell receptor alpha variable 8-4	113	12377	6.81	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE2	14
+NX_P01742	Immunoglobulin heavy variable 1-69	117	12659	9.26	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01743	Immunoglobulin heavy variable 1-46	117	12933	9.1	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01762	Immunoglobulin heavy variable 3-11	117	12909	8.82	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01763	Immunoglobulin heavy variable 3-48	117	12813	5.31	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	The N-terminus is blocked.	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01764	Immunoglobulin heavy variable 3-23	117	12582	8.49	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01766	Immunoglobulin heavy variable 3-13	116	12506	6.54	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01767	Immunoglobulin heavy variable 3-53	116	12770	8.49	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01768	Immunoglobulin heavy variable 3-30	117	12947	9.1	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01772	Immunoglobulin heavy variable 3-33	117	13074	9.12	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01780	Immunoglobulin heavy variable 3-7	117	12943	6.21	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01782	Immunoglobulin heavy variable 3-9	118	12945	6.55	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01814	Immunoglobulin heavy variable 2-70	119	13260	6.1	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01817	Immunoglobulin heavy variable 2-5	119	13231	8.49	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01824	Immunoglobulin heavy variable 4-39	125	13917	9.35	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01825	Immunoglobulin heavy variable 4-59	116	12936	9.36	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P01833	Polymeric immunoglobulin receptor	764	83284	5.59	1	Secreted;Cell membrane	NA	This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.	N-glycosylation is not necessary for Ig binding.	NA	Intestinal immune network for IgA production;Neutrophil degranulation	PE1	1
+NX_P01834	Immunoglobulin kappa constant	107	11765	6.11	0	Secreted;Cell membrane	Immunoglobulin kappa light chain deficiency	Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P01848	T cell receptor alpha constant	140	15717	4.58	1	Cell membrane	Immunodeficiency 7	Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	14
+NX_P01850	T cell receptor beta constant 1	176	19769	5.8	1	Cell membrane	NA	Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:9382891, PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	7
+NX_P01854	Immunoglobulin heavy constant epsilon	428	47019	8.39	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Fc epsilon receptor (FCERI) signaling;Interleukin-4 and Interleukin-13 signaling	PE1	14
+NX_P01857	Immunoglobulin heavy constant gamma 1	330	36106	8.46	0	Secreted;Cell membrane	Multiple myeloma	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	Regulation of actin dynamics for phagocytic cup formation;Regulation of Complement cascade;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Interleukin-4 and Interleukin-13 signaling	PE1	14
+NX_P01859	Immunoglobulin heavy constant gamma 2	326	35901	7.66	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	Regulation of actin dynamics for phagocytic cup formation;Regulation of Complement cascade;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation	PE1	14
+NX_P01860	Immunoglobulin heavy constant gamma 3	377	41287	8.23	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	N-linked glycans at Asn-227 are diantennary core fucosylated structures without bisecting GlcNAc (HexNAc4Hex4Fuc1, HexNAc4Hex5Fuc1, and HexNAc4Hex5Fuc1Sia1).;O-linked glycans are non-, mono- and disialylated core 1-type O-glycans.;N-linked glycans at Asn-322 are noncore fucosylated and the vast majority are diantennary species with a bisecting GlcNAc. Among them the most dominant glycans are HexNAc5Hex4, HexNAc5Hex5, and HexNAc5Hex5Sia1.	NA	Regulation of actin dynamics for phagocytic cup formation;Regulation of Complement cascade;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation	PE1	14
+NX_P01861	Immunoglobulin heavy constant gamma 4	327	35941	7.18	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	Regulation of actin dynamics for phagocytic cup formation;Regulation of Complement cascade;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Interleukin-4 and Interleukin-13 signaling	PE1	14
+NX_P01871	Immunoglobulin heavy constant mu	453	49440	6.35	0	Secreted;Cell membrane	Agammaglobulinemia 1, autosomal recessive	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553).	NA	NA	Cell surface interactions at the vascular wall;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CD22 mediated BCR regulation	PE1	14
+NX_P01876	Immunoglobulin heavy constant alpha 1	353	37655	6.08	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).	3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.;N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4.	NA	Cell surface interactions at the vascular wall;Scavenging of heme from plasma	PE1	14
+NX_P01877	Immunoglobulin heavy constant alpha 2	340	36591	5.86	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).	NA	NA	Cell surface interactions at the vascular wall;Scavenging of heme from plasma	PE1	14
+NX_P01880	Immunoglobulin heavy constant delta	384	42353	8.38	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD (PubMed:8774350, PubMed:10702483, PubMed:11282392).	NA	NA	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CD22 mediated BCR regulation	PE1	14
+NX_P01889	HLA class I histocompatibility antigen, B alpha chain	362	40460	5.57	1	Endoplasmic reticulum membrane;Cell membrane	Stevens-Johnson syndrome;Spondyloarthropathy 1	Allele B*07:02: Presents a long peptide (APRGPHGGAASGL) derived from the cancer-testis antigen CTAG1A/NY-ESO-1, eliciting a polyclonal CD8-positive T cell response against tumor cells.;Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity. Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:29531227). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227).	HLA-B is phosphorylated by PRKACA	NA	Endocytosis;Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Type I diabetes mellitus;HTLV-I infection;Herpes simplex infection;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;Viral myocarditis	PE1	6
+NX_P01893	Putative HLA class I histocompatibility antigen, alpha chain H	362	40892	5.91	1	Cell membrane	NA	Involved in the presentation of foreign antigens to the immune system.	NA	Belongs to the MHC class I family.	ER-Phagosome pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Endosomal/Vacuolar pathway;Interferon gamma signaling;Interferon alpha/beta signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Neutrophil degranulation	PE5	6
+NX_P01903	HLA class II histocompatibility antigen, DR alpha chain	254	28607	4.91	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;Lysosome membrane;trans-Golgi network membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 or MARCH8 at Lys-244 leading to down-regulation of MHC class II. When associated with ubiquitination of the beta subunit of HLA-DR: HLA-DRB4 'Lys-254', the down-regulation of MHC class II may be highly effective.	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Hematopoietic cell lineage;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P01906	HLA class II histocompatibility antigen, DQ alpha 2 chain	255	28033	4.78	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;Lysosome membrane;trans-Golgi network membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	NA	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P01909	HLA class II histocompatibility antigen, DQ alpha 1 chain	254	27805	5.44	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;Lysosome membrane;trans-Golgi network membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	NA	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P01911	HLA class II histocompatibility antigen, DRB1-15 beta chain	266	29966	7.64	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;trans-Golgi network membrane;Lysosome membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Hematopoietic cell lineage;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P01912	HLA class II histocompatibility antigen, DRB1-3 chain	266	30120	8.21	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;trans-Golgi network membrane;Lysosome membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P01920	HLA class II histocompatibility antigen, DQ beta 1 chain	261	29991	6.76	1	Cytoplasm;Golgi apparatus;Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;trans-Golgi network membrane;Lysosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	NA	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P02008	Hemoglobin subunit zeta	142	15637	7.94	0	Nucleoplasm;Cytosol	NA	The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.	NA	Belongs to the globin family.	NA	PE1	16
+NX_P02042	Hemoglobin subunit delta	147	16055	7.84	0	NA	NA	Involved in oxygen transport from the lung to the various peripheral tissues.	NA	Belongs to the globin family.	African trypanosomiasis;Malaria;Factors involved in megakaryocyte development and platelet production	PE1	11
+NX_P02100	Hemoglobin subunit epsilon	147	16203	8.67	0	NA	NA	The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.	NA	Belongs to the globin family.	Factors involved in megakaryocyte development and platelet production	PE1	11
+NX_P02144	Myoglobin	154	17184	7.14	0	NA	NA	Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	NA	Belongs to the globin family.	Intracellular oxygen transport	PE1	22
+NX_P02452	Collagen alpha-1(I) chain	1464	138941	5.6	0	Cytoplasmic vesicle;Cytosol;Extracellular matrix	Caffey disease;Ehlers-Danlos syndrome, arthrochalasia type, 1;Osteogenesis imperfecta 3;Osteogenesis imperfecta 4;Osteoporosis;Osteogenesis imperfecta 1;Ehlers-Danlos syndrome, classic type, 1;Osteogenesis imperfecta 2	Type I collagen is a member of group I collagen (fibrillar forming collagen).	Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains.;O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide.;Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline.;Contains mostly 4-hydroxyproline. Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the fibrillar collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;GPVI-mediated activation cascade;Collagen degradation;Collagen biosynthesis and modifying enzymes;Syndecan interactions;Integrin cell surface interactions;Cell surface interactions at the vascular wall;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Scavenging by Class A Receptors;Non-integrin membrane-ECM interactions;Platelet Adhesion to exposed collagen;Crosslinking of collagen fibrils;Anchoring fibril formation;GP1b-IX-V activation signalling;Platelet Aggregation (Plug Formation);Extracellular matrix organization;MET activates PTK2 signaling;Collagen chain trimerization;RUNX2 regulates osteoblast differentiation	PE1	17
+NX_P02458	Collagen alpha-1(II) chain	1487	141785	6.58	0	Nucleoplasm;Extracellular matrix	Osteoarthritis with mild chondrodysplasia;Platyspondylic lethal skeletal dysplasia Torrance type;Spondyloepiphyseal dysplasia congenital type;Stickler syndrome 1 non-syndromic ocular;Spondyloepiphyseal dysplasia, Stanescu type;Stickler syndrome 1;Czech dysplasia;Rhegmatogenous retinal detachment autosomal dominant;Spondyloperipheral dysplasia;Spondyloepimetaphyseal dysplasia, Strudwick type;Multiple epiphyseal dysplasia with myopia and conductive deafness;Legg-Calve-Perthes disease;Kniest dysplasia;Achondrogenesis 2;Avascular necrosis of femoral head, primary, 1	Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.	Contains mostly 4-hydroxyproline. Prolines at the third position of the tripeptide repeating unit (G-X-P) are 4-hydroxylated in some or all of the chains.;Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains.;The N-telopeptide is covalently linked to the helical COL2 region of alpha 1(IX), alpha 2(IX) and alpha 3(IX) chain. The C-telopeptide is covalently linked to an another site in the helical region of alpha 3(IX) COL2.;Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline.;O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide.	Belongs to the fibrillar collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Non-integrin membrane-ECM interactions;Extracellular matrix organization;MET activates PTK2 signaling;Collagen chain trimerization	PE1	12
+NX_P02461	Collagen alpha-1(III) chain	1466	138564	6.21	0	Endoplasmic reticulum;Extracellular matrix	Ehlers-Danlos syndrome, vascular type;Polymicrogyria with or without vascular-type Ehlers-Danlos syndrome	Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.	O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.;Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the fibrillar collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Syndecan interactions;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Scavenging by Class A Receptors;Non-integrin membrane-ECM interactions;Extracellular matrix organization;MET activates PTK2 signaling;Collagen chain trimerization	PE1	2
+NX_P02462	Collagen alpha-1(IV) chain	1669	160611	8.55	0	Basement membrane	Schizencephaly;Intracerebral hemorrhage;Hereditary angiopathy with nephropathy aneurysms and muscle cramps;Brain small vessel disease 1 with or without ocular anomalies;Tortuosity of retinal arteries	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.;Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.	Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding (PubMed:2844531). 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.;Contains 3-hydroxyproline. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline.;Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated. The modified lysines can be O-glycosylated.;Proteolytic processing produces the C-terminal NC1 peptide, arresten.;The trimeric structure of the NC1 domains is stabilized by covalent bonds (sulfilimine cross-links) between Lys and Met residues (PubMed:12011424). These cross-links are important for the mechanical stability of the basement membrane (By similarity).;Contains 4-hydroxyproline (Probable). Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains (By similarity).	Belongs to the type IV collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Pathways in cancer;Small cell lung cancer;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Scavenging by Class A Receptors;Non-integrin membrane-ECM interactions;Laminin interactions;Crosslinking of collagen fibrils;Anchoring fibril formation;Extracellular matrix organization;Collagen chain trimerization	PE1	13
+NX_P02489	Alpha-crystallin A chain	173	19909	5.77	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	Cataract 9, multiple types	Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Phosphorylation on Ser-122 seems to be developmentally regulated. Absent in the first months of life, it appears during the first 12 years of human lifetime. The relative amount of phosphorylated form versus unphosphorylated form does not change over the lifetime of the individual.;O-glycosylated; contains N-acetylglucosamine side chains.;Deamidation of Asn-101 in lens occurs mostly during the first 30 years of age, followed by a small additional amount of deamidation (approximately 5%) during the next approximately 38 years, resulting in a maximum of approximately 50% deamidation during the lifetime of the individual.;Undergoes age-dependent proteolytical cleavage at the C-terminus. Alpha-crystallin A(1-172) is the most predominant form produced most rapidly during the first 12 years of age and after this age is present in approximately 50% of the lens molecules.;Acetylation at Lys-70 seems to increase chaperone activity.	Belongs to the small heat shock protein (HSP20) family.	Protein processing in endoplasmic reticulum	PE1	21
+NX_P02511	Alpha-crystallin B chain	175	20159	6.76	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	Myopathy, myofibrillar, 2;Myopathy, myofibrillar, fatal infantile hypertonic, alpha-B crystallin-related;Cardiomyopathy, dilated 1II;Cataract 16, multiple types	May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	NA	Belongs to the small heat shock protein (HSP20) family.	Protein processing in endoplasmic reticulum;HSF1-dependent transactivation	PE1	11
+NX_P02533	Keratin, type I cytoskeletal 14	472	51561	5.09	0	Cytoplasm;Nucleus	Epidermolysis bullosa simplex, Weber-Cockayne type;Naegeli-Franceschetti-Jadassohn syndrome;Dermatopathia pigmentosa reticularis;Epidermolysis bullosa simplex, autosomal recessive 1;Epidermolysis bullosa simplex, Koebner type;Epidermolysis bullosa simplex, Dowling-Meara type	The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.	Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex.;A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.	Belongs to the intermediate filament family.	Type I hemidesmosome assembly;Formation of the cornified envelope;Keratinization	PE1	17
+NX_P02538	Keratin, type II cytoskeletal 6A	564	60045	8.09	0	NA	Pachyonychia congenita 3	Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_P02545	Prelamin-A/C	664	74139	6.57	0	Nucleus speckle;Nucleoplasm;Nucleus lamina;Nucleus envelope;Cytosol;Nucleus	Emery-Dreifuss muscular dystrophy 3, autosomal recessive;Lethal tight skin contracture syndrome;Charcot-Marie-Tooth disease 2B1;Lipodystrophy, familial partial, 2;Cardiomyopathy, dilated, with hypergonadotropic hypogonadism;Muscular dystrophy congenital LMNA-related;Heart-hand syndrome Slovenian type;Emery-Dreifuss muscular dystrophy 2, autosomal dominant;Hutchinson-Gilford progeria syndrome;Cardiomyopathy, dilated 1A;Mandibuloacral dysplasia with type A lipodystrophy	Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.;Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920).	Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.;Farnesylation of prelamin-A/C facilitates nuclear envelope targeting.;Proteolytic cleavage of the C-terminal of 18 residues of prelamin-A/C results in the production of lamin-A/C. The prelamin-A/C maturation pathway includes farnesylation of CAAX motif, ZMPSTE24/FACE1 mediated cleavage of the last three amino acids, methylation of the C-terminal cysteine and endoproteolytic removal of the last 15 C-terminal amino acids. Proteolytic cleavage requires prior farnesylation and methylation, and absence of these blocks cleavage.;Sumoylation is necessary for the localization to the nuclear envelope.	Belongs to the intermediate filament family.	Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;XBP1(S) activates chaperone genes;Meiotic synapsis;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina;Breakdown of the nuclear lamina;Signaling by BRAF and RAF fusions;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Nuclear Envelope Breakdown	PE1	1
+NX_P02549	Spectrin alpha chain, erythrocytic 1	2419	280014	4.95	0	Cell cortex;Cytoskeleton	Hereditary pyropoikilocytosis;Elliptocytosis 2;Spherocytosis 3	Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.	NA	Belongs to the spectrin family.	RAF/MAP kinase cascade;Interaction between L1 and Ankyrins;NCAM signaling for neurite out-growth;COPI-mediated anterograde transport	PE1	1
+NX_P02585	Troponin C, skeletal muscle	160	18122	4.06	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle	NA	Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.	NA	Belongs to the troponin C family.	Calcium signaling pathway;Striated Muscle Contraction	PE1	20
+NX_P02647	Apolipoprotein A-I	267	30778	5.56	0	Cytoplasmic vesicle;Cytosol;Secreted	High density lipoprotein deficiency 2;Amyloidosis 8;High density lipoprotein deficiency 1	Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.	Phosphorylation sites are present in the extracellular medium.;Glycosylated.;Palmitoylated.	Belongs to the apolipoprotein A1/A4/E family.	PPAR signaling pathway;Fat digestion and absorption;Vitamin digestion and absorption;African trypanosomiasis;Retinoid metabolism and transport;PPARA activates gene expression;Amyloid fiber formation;Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Scavenging by Class A Receptors;ABC transporters in lipid homeostasis;Scavenging of heme from plasma;Scavenging by Class B Receptors;Defective ABCA1 causes Tangier disease;Post-translational protein phosphorylation;HDL assembly;HDL remodeling;HDL clearance;Chylomicron remodeling;Chylomicron assembly	PE1	11
+NX_P02649	Apolipoprotein E	317	36154	5.65	0	Cytoplasmic vesicle;Extracellular matrix;Secreted;Extracellular space	Sea-blue histiocyte disease;Familial hypercholesterolemia;Alzheimer disease 2;Hyperlipoproteinemia 3;Lipoprotein glomerulopathy	APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (PubMed:6860692, PubMed:1911868, PubMed:14754908). APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance (PubMed:6860692, PubMed:2762297, PubMed:1911868, PubMed:1917954, PubMed:9395455, PubMed:14754908, PubMed:23620513). Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma (PubMed:6860692, PubMed:2762297, PubMed:9395455). As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL) (PubMed:6860692, PubMed:1911868). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles (PubMed:2762297, PubMed:1917954, PubMed:7768901, PubMed:8939961, PubMed:12950167, PubMed:20030366, PubMed:2063194, PubMed:8756331, PubMed:20303980, PubMed:1530612, PubMed:7635945). Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells (PubMed:9395455, PubMed:9488694, PubMed:23676495, PubMed:7635945). A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes (PubMed:1911868, PubMed:1917954, PubMed:9395455, PubMed:23676495, PubMed:29516132). APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues (PubMed:2762297, PubMed:29516132). By participating to the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis (PubMed:2762297, PubMed:1917954, PubMed:29516132). APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis (PubMed:9395455, PubMed:14754908, PubMed:23620513). First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues (PubMed:14754908, PubMed:23620513). Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes (PubMed:9395455). APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting (PubMed:8939961, PubMed:25173806). APOE in also involved in innate and adaptive immune responses, controlling for instance the survival of myeloid-derived suppressor cells (By similarity). APOE, may also play a role in transcription regulation through a receptor-dependent and cholesterol-independent mechanism, that activates MAP3K12 and a non-canonical MAPK signal transduction pathway that results in enhanced AP-1-mediated transcription of APP (PubMed:28111074).	Glycated in plasma VLDL of normal subjects, and of hyperglycemic diabetic patients at a higher level (2-3 fold).;Phosphorylated by FAM20C in the extracellular medium.;APOE exists as multiple glycosylated and sialylated glycoforms within cells and in plasma (PubMed:29516132). The extent of glycosylation and sialylation are tissue and context specific (PubMed:29516132). Plasma APOE undergoes desialylation and is less glycosylated and sialylated than the cellular form (PubMed:2498325, PubMed:19838169, PubMed:20511397, PubMed:23234360). Glycosylation is not required for proper expression and secretion (PubMed:2498325). O-glycosylated with core 1 or possibly core 8 glycans. Thr-307 and Ser-314 are minor glycosylation sites compared to Ser-308 (PubMed:19838169, PubMed:23234360).;Undergoes C-terminal proteolytic processing in neurons. C-terminally truncated APOE has a tendency to form neurotoxic intracellular neurofibrillary tangle-like inclusions in neurons.	Belongs to the apolipoprotein A1/A4/E family.	Alzheimer's disease;Retinoid metabolism and transport;Nuclear signaling by ERBB4;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Scavenging by Class A Receptors;Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors;Post-translational protein phosphorylation;Chylomicron clearance;HDL remodeling;Chylomicron remodeling;Chylomicron assembly	PE1	19
+NX_P02652	Apolipoprotein A-II	100	11175	6.27	0	Secreted	NA	May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.	Apolipoprotein A-II is O-glycosylated.;Phosphorylation sites are present in the extracellular medium.	Belongs to the apolipoprotein A2 family.	PPAR signaling pathway;Retinoid metabolism and transport;PPARA activates gene expression;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Chylomicron remodeling;Chylomicron assembly	PE1	1
+NX_P02654	Apolipoprotein C-I	83	9332	8.01	0	Endoplasmic reticulum;Secreted	NA	Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.	NA	Belongs to the apolipoprotein C1 family.	VLDL assembly;VLDL clearance	PE1	19
+NX_P02655	Apolipoprotein C-II	101	11284	4.72	0	Secreted	Hyperlipoproteinemia 1B	Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.	Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.;Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.	Belongs to the apolipoprotein C2 family.	Retinoid metabolism and transport;Assembly of active LPL and LIPC lipase complexes;HDL remodeling;Chylomicron remodeling;Chylomicron assembly	PE1	19
+NX_P02656	Apolipoprotein C-III	99	10852	5.23	0	Nucleoplasm;Cell junction;Secreted;Nucleolus	Hyperalphalipoproteinemia 2	Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013).	The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.	Belongs to the apolipoprotein C3 family.	PPAR signaling pathway;Retinoid metabolism and transport;HDL remodeling;Chylomicron remodeling;Chylomicron assembly	PE1	11
+NX_P02671	Fibrinogen alpha chain	866	94973	5.7	0	Endoplasmic reticulum;Secreted	Amyloidosis 8;Congenital afibrinogenemia;Dysfibrinogenemia, congenital	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.	O-glycosylated.;About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.;Phosphorylated by FAM20C in the extracellular medium.;Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.;Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.;The alpha chain is normally not N-glycosylated (PubMed:23151259), even though glycosylation at Asn-686 was observed when a fragment of the protein was expressed in insect cells (PubMed:9689040). It is well known that heterologous expression of isolated domains can lead to adventitious protein modifications. Besides, glycosylation at Asn-686 is supported by large-scale glycoproteomics studies (PubMed:16335952 and PubMed:19159218), but the evidence is still quite tenuous. Most likely, Asn-686 is not glycosylated in the healthy human body, or only with low efficiency.	NA	Complement and coagulation cascades;Amyloid fiber formation;MAP2K and MAPK activation;Integrin cell surface interactions;Common Pathway of Fibrin Clot Formation;Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;Regulation of TLR by endogenous ligand;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Post-translational protein phosphorylation	PE1	4
+NX_P02675	Fibrinogen beta chain	491	55928	8.54	0	Endoplasmic reticulum;Secreted	Congenital afibrinogenemia;Dysfibrinogenemia, congenital	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.	Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.	NA	Complement and coagulation cascades;MAP2K and MAPK activation;Integrin cell surface interactions;Common Pathway of Fibrin Clot Formation;Platelet degranulation;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;Regulation of TLR by endogenous ligand;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	4
+NX_P02679	Fibrinogen gamma chain	453	51512	5.37	0	Endoplasmic reticulum;Secreted	Congenital afibrinogenemia;Dysfibrinogenemia, congenital	Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.	Sulfation of C-terminal tyrosines increases affinity for thrombin.;Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.	NA	Complement and coagulation cascades;Staphylococcus aureus infection;MAP2K and MAPK activation;Integrin cell surface interactions;Common Pathway of Fibrin Clot Formation;Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;Regulation of TLR by endogenous ligand;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Post-translational protein phosphorylation	PE1	4
+NX_P02686	Myelin basic protein	304	33117	9.79	0	Myelin membrane;Nucleus;Cell membrane	NA	The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.	The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).;Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.;Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.;Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic.;MBP is phosphorylated by TAOK2	Belongs to the myelin basic protein family.	NA	PE1	18
+NX_P02689	Myelin P2 protein	132	14909	9.84	0	Cytoplasm	Charcot-Marie-Tooth disease, demyelinating, 1G	May play a role in lipid transport protein in Schwann cells. May bind cholesterol.	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	NA	PE1	8
+NX_P02708	Acetylcholine receptor subunit alpha	482	54546	5.78	4	Cell membrane;Postsynaptic cell membrane	Multiple pterygium syndrome, lethal type;Myasthenic syndrome, congenital, 1A, slow-channel;Myasthenic syndrome, congenital, 1B, fast-channel	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.	Neuroactive ligand-receptor interaction;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly calcium permeable nicotinic acetylcholine receptors	PE1	2
+NX_P02724	Glycophorin-A	150	16331	5.29	1	Nucleoplasm;Cytosol;Cell membrane	NA	Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).	The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).	Belongs to the glycophorin A family.	Hematopoietic cell lineage;Malaria;Cell surface interactions at the vascular wall	PE1	4
+NX_P02730	Band 3 anion transport protein	911	101792	5.08	12	Basolateral cell membrane;Cell membrane	Renal tubular acidosis, distal, autosomal dominant;Ovalocytosis, Southeast Asian;Cryohydrocytosis;Renal tubular acidosis, distal, with hemolytic anemia;Spherocytosis 4;Renal tubular acidosis, distal, with normal red cell morphology	Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.	Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation.;N-glycosylated.;Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1-resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation.	Belongs to the anion exchanger (TC 2.A.31) family.	Collecting duct acid secretion;Bicarbonate transporters;Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	PE1	17
+NX_P02741	C-reactive protein	224	25039	5.45	0	Cytoplasmic vesicle;Nucleoplasm;Secreted;Cytoskeleton	NA	Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.	NA	Belongs to the pentraxin family.	Classical antibody-mediated complement activation	PE1	1
+NX_P02743	Serum amyloid P-component	223	25387	6.1	0	Secreted	NA	Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.	N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148).	Belongs to the pentraxin family.	Amyloid fiber formation	PE1	1
+NX_P02745	Complement C1q subcomponent subunit A	245	26017	9.26	0	Secreted	Complement component C1q deficiency	C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.	O-linked glycans are assumed to be the Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains.	NA	Complement and coagulation cascades;Prion diseases;Pertussis;Chagas disease (American trypanosomiasis);Staphylococcus aureus infection;Systemic lupus erythematosus;Regulation of Complement cascade;Initial triggering of complement;Classical antibody-mediated complement activation	PE1	1
+NX_P02746	Complement C1q subcomponent subunit B	253	26722	8.83	0	Secreted	Complement component C1q deficiency	C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.	Hydroxylated on lysine and proline residues. Hydroxylated lysine residues can be glycosylated. Human C1Q contains up to 68.3 hydroxylysine-galactosylglucose residues and up to 2.5 hydroxylysine-galactose per molecule. Total percentage hydroxylysine residues glycosylated is 86.4%.	NA	Complement and coagulation cascades;Prion diseases;Pertussis;Chagas disease (American trypanosomiasis);Staphylococcus aureus infection;Systemic lupus erythematosus;Regulation of Complement cascade;Initial triggering of complement;Classical antibody-mediated complement activation	PE1	1
+NX_P02747	Complement C1q subcomponent subunit C	245	25774	8.61	0	Secreted	Complement component C1q deficiency	C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.	O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.	NA	Complement and coagulation cascades;Prion diseases;Pertussis;Chagas disease (American trypanosomiasis);Staphylococcus aureus infection;Systemic lupus erythematosus;Regulation of Complement cascade;Initial triggering of complement;Classical antibody-mediated complement activation	PE1	1
+NX_P02748	Complement component C9	559	63173	5.43	2	Secreted;Target cell membrane	Macular degeneration, age-related, 15;Complement component 9 deficiency	Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore-forming subunit of the MAC (PubMed:4055801, PubMed:26841934, PubMed:30111885).	Thrombin cleaves factor C9 to produce C9a and C9b.;Initially, positions and connectivity of disulfide bonds were based on peptide sequencing done for the human protein (PubMed:8603752). The crystal structures for the human and mouse proteins corrected the positions and connectivities of the disulfide bonds (PubMed:30111885). The distance between Cys-57 and Cys-94 in the monomeric mouse protein precludes formation of a disulfide bond, contrary to what is seen in the structure of the human polymeric form of the protein (Probable).;Phosphorylation sites are present in the extracellular medium.	Belongs to the complement C6/C7/C8/C9 family.	Complement and coagulation cascades;Prion diseases;Amoebiasis;Systemic lupus erythematosus;Terminal pathway of complement;Regulation of Complement cascade	PE1	5
+NX_P02749	Beta-2-glycoprotein 1	345	38298	8.34	0	Golgi apparatus;Secreted	NA	Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.	N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele.	NA	Platelet degranulation	PE1	17
+NX_P02750	Leucine-rich alpha-2-glycoprotein	347	38178	6.45	0	Cytoplasmic vesicle;Secreted	NA	NA	NA	NA	Neutrophil degranulation	PE1	19
+NX_P02751	Fibronectin	2477	272320	5.32	0	Extracellular matrix	Glomerulopathy with fibronectin deposits 2;Spondylometaphyseal dysplasia, corner fracture type	Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.;Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.	Sulfated.;Proteolytic processing produces the C-terminal NC1 peptide, anastellin.;Some lysine residues are oxidized to allysine by LOXL3, promoting fibronectin activation and matrix formation.;It is not known whether both or only one of Thr-2155 and Thr-2156 are/is glycosylated.;Phosphorylated by FAM20C in the extracellular medium.;Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. Fibrinogen-fibronectin, collagen-fibronectin heteropolymers).	NA	Focal adhesion;ECM-receptor interaction;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Amoebiasis;Pathways in cancer;Small cell lung cancer;Degradation of the extracellular matrix;Syndecan interactions;MAP2K and MAPK activation;Integrin cell surface interactions;Cell surface interactions at the vascular wall;Platelet degranulation;ECM proteoglycans;Molecules associated with elastic fibres;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Non-integrin membrane-ECM interactions;Integrin alphaIIb beta3 signaling;Fibronectin matrix formation;GRB2:SOS provides linkage to MAPK signaling for Integrins;Extracellular matrix organization;p130Cas linkage to MAPK signaling for integrins;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates PTK2 signaling;Interleukin-4 and Interleukin-13 signaling;Post-translational protein phosphorylation	PE1	2
+NX_P02753	Retinol-binding protein 4	201	23010	5.76	0	Secreted	Retinal dystrophy, iris coloboma, and comedogenic acne syndrome;Microphthalmia, isolated, with coloboma, 10	Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).	NA	Belongs to the calycin superfamily. Lipocalin family.	The canonical retinoid cycle in rods (twilight vision);Retinoid metabolism and transport;Retinoid cycle disease events;Retinoid metabolism disease events	PE1	10
+NX_P02760	Protein AMBP	352	38999	5.95	0	Golgi apparatus;Cytosol;Secreted	NA	Trypstatin is a trypsin inhibitor.;Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.	Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate.;N- and O-glycosylated. N-glycan heterogeneity at Asn-115: Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor). N-glycan at Asn-250: Hex5HexNAc4. O-linkage of the glycosaminoglycan, chondroitin sulfate, at Ser-215 allows cross-linking between the three polypeptide chains.;The precursor is proteolytically processed into separately functioning proteins.;3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.	In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.	Scavenging of heme from plasma	PE1	9
+NX_P02763	Alpha-1-acid glycoprotein 1	201	23512	4.93	0	Secreted	NA	Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.	N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).	Belongs to the calycin superfamily. Lipocalin family.	Platelet degranulation;Neutrophil degranulation	PE1	9
+NX_P02765	Alpha-2-HS-glycoprotein	367	39341	5.43	0	Golgi apparatus;Secreted	Alopecia-mental retardation syndrome 1	Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.	Phosphorylated by FAM20C in the extracellular medium.;O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).	Belongs to the fetuin family.	Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation	PE1	3
+NX_P02766	Transthyretin	147	15887	5.52	0	Golgi apparatus;Cytoplasm;Secreted	Amyloidosis, transthyretin-related;Hyperthyroxinemia, dystransthyretinemic;Carpal tunnel syndrome 1	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.	Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.	Belongs to the transthyretin family.	The canonical retinoid cycle in rods (twilight vision);Retinoid metabolism and transport;Amyloid fiber formation;Non-integrin membrane-ECM interactions;Retinoid cycle disease events;Neutrophil degranulation	PE1	18
+NX_P02768	Serum albumin	609	69367	5.92	0	Endoplasmic reticulum;Golgi apparatus;Secreted	Hyperthyroxinemia, familial dysalbuminemic;Analbuminemia	Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017).	Phosphorylated by FAM20C in the extracellular medium.;Glycated in diabetic patients.;Acetylated on Lys-223 by acetylsalicylic acid.;Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.	Belongs to the ALB/AFP/VDB family.	Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Transport of organic anions;Scavenging of heme from plasma;Recycling of bile acids and salts;Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR);Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR);Post-translational protein phosphorylation;HDL remodeling	PE1	4
+NX_P02771	Alpha-fetoprotein	609	68678	5.48	0	Golgi apparatus;Cytosol;Secreted	Alpha-fetoprotein, hereditary persistence;Alpha-fetoprotein deficiency	Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.	Sulfated.;Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.	Belongs to the ALB/AFP/VDB family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	4
+NX_P02774	Vitamin D-binding protein	474	52918	5.32	0	Secreted	NA	Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.	Allele GC*1S is O-glycosylated at Thr-436 (PubMed:20079467). The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated (PubMed:17360250). The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.	Belongs to the ALB/AFP/VDB family.	Vitamin D (calciferol) metabolism	PE1	4
+NX_P02775	Platelet basic protein	128	13894	9.04	0	Secreted	NA	LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.	NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets.;NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils.;Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor.;Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)).	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines;Platelet degranulation;Neutrophil degranulation	PE1	4
+NX_P02776	Platelet factor 4	101	10845	8.93	0	Secreted	NA	Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.	NA	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines;Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall;Platelet degranulation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	4
+NX_P02778	C-X-C motif chemokine 10	98	10881	9.93	0	Secreted	NA	Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).	Several proteases can mediate post-secretion cleavages. DPP4 cleaves CXCL10 on its N-terminal 2 amino acids leading to an antagonist form of CXCL10. This dominant negative form is capable of binding CXCR3 but does not induce signaling. MMP9 cleaves 9 amino acids instead.	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Influenza A;G alpha (i) signalling events;Chemokine receptors bind chemokines;Interleukin-10 signaling	PE1	4
+NX_P02786	Transferrin receptor protein 1	760	84871	6.18	1	Cell membrane;Secreted;Endosome;Melanosome;Lysosome	Immunodeficiency 46	(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.;Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).	Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).;Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.;N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.	Belongs to the peptidase M28 family. M28B subfamily.	Endocytosis;Phagosome;Hematopoietic cell lineage;Transferrin endocytosis and recycling;Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	3
+NX_P02787	Serotransferrin	698	77064	6.81	0	Secreted	Atransferrinemia	Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.	NA	Belongs to the transferrin family.	Mineral absorption;Transferrin endocytosis and recycling;Platelet degranulation;Iron uptake and transport;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation	PE1	3
+NX_P02788	Lactotransferrin	710	78182	8.5	0	Cytoplasm;Cytoplasmic granule;Secreted;Nucleus	NA	Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.;The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites.;Kaliocin-1 has antimicrobial activity and is able to permeabilize different ions through liposomal membranes.;Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site.;Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.;Transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELENOH promoters.;Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection. Can inhibit papillomavirus infections. Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling. Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells. Stimulates VEGFA-mediated endothelial cell migration and proliferation. Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs). Also binds specifically to pneumococcal surface protein A (pspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA.	Ubiquitinated at Lys-379 and Lys-391.;Poly-N-acetyllactosaminic carbohydrate moiety seems to be needed for TLR4 activation.	Belongs to the transferrin family.	Amyloid fiber formation;Mtb iron assimilation by chelation;Neutrophil degranulation;Antimicrobial peptides;Metal sequestration by antimicrobial proteins	PE1	3
+NX_P02790	Hemopexin	462	51676	6.55	0	Secreted	NA	Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylation in the 30-40 region is minor compared to glycosylation at Thr-24 and Thr-29.	Belongs to the hemopexin family.	Scavenging of heme from plasma	PE1	11
+NX_P02792	Ferritin light chain	175	20020	5.51	0	Cytosol	Hyperferritinemia with or without cataract;Neurodegeneration with brain iron accumulation 3;L-ferritin deficiency	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	NA	Belongs to the ferritin family.	Porphyrin and chlorophyll metabolism;Mineral absorption;Golgi Associated Vesicle Biogenesis;Iron uptake and transport;Scavenging by Class A Receptors;Neutrophil degranulation	PE1	19
+NX_P02794	Ferritin heavy chain	183	21226	5.31	0	Cytoskeleton	Hemochromatosis 5	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	NA	Belongs to the ferritin family.	Porphyrin and chlorophyll metabolism;Mineral absorption;Golgi Associated Vesicle Biogenesis;Iron uptake and transport;Scavenging by Class A Receptors;Neutrophil degranulation	PE1	11
+NX_P02795	Metallothionein-2	61	6042	8.23	0	Nucleolus;Nucleus	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	NA	Belongs to the metallothionein superfamily. Type 1 family.	Mineral absorption;Interferon gamma signaling;Metallothioneins bind metals	PE1	16
+NX_P02808	Statherin	62	7304	8.01	0	Secreted	NA	Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.	Sulfated on tyrosine residues.;Substrate for transglutaminase-2. More than 95% of the cyclized peptide is cyclo-statherin Q-37, and less than 5% is cyclo-statherin Q-39. Cyclized forms account for about 1% of total statherin in saliva.	Belongs to the histatin/statherin family.	Salivary secretion	PE1	4
+NX_P02810	Salivary acidic proline-rich phosphoprotein 1/2	166	17016	4.63	0	Secreted	NA	PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.	An hexuronic acid was shown to be linked to Ser-33 in about 40% of the polypeptides. Neither the structure of the carbohydrate (whether glucuronic acid or an isomer of), nor the linkage (whether a glycoside or an ester) has been definitely established.;Proteolytically cleaved; PRP-2, PRP-1, PIF-S and Db-S yield PRP-4, PRP-3 (protein A), PIF-F and Db-F, respectively.	NA	Salivary secretion;Salivary secretion	PE1	12
+NX_P02812	Basic salivary proline-rich protein 2	416	40799	11.63	0	Secreted	NA	NA	Pyroglutamate formation occurs on terminal Gln residues of cleaved peptides. Pyroglutamate formation found on at least Gln-398 and Gln-400.;Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine. The endoprotease may be of microbial origin.;N- and O-glycosylated. In head and neck cancer patients, O-glycosylated with glucosylgalactosyl carbohydrate moiety. This modification would require prior hydroxylation on the lysine residue.	NA	NA	PE1	12
+NX_P02814	Submaxillary gland androgen-regulated protein 3B	79	8188	9.62	0	Secreted	NA	NA	P-A and D1A are probably degradation products of P-B.	Belongs to the PROL1/PROL3 family.	NA	PE1	4
+NX_P02818	Osteocalcin	100	10963	6.56	0	Secreted	NA	Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.	Belongs to the osteocalcin/matrix Gla protein family.	Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins;RUNX2 regulates osteoblast differentiation	PE1	1
+NX_P03372	Estrogen receptor	595	66216	8.3	0	Golgi apparatus;Cytoplasm;Cell membrane;Nucleoplasm;Cytoplasmic vesicle;Nucleus	Estrogen resistance	Can bind to ERE and inhibit isoform 1.;Is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.;Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades.	Palmitoylated (isoform 3). Not biotinylated (isoform 3).;Glycosylated; contains N-acetylglucosamine, probably O-linked.;Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor.;Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization (PubMed:18657504, PubMed:24498420). Demethylated by JMJD6 at Arg-260 (PubMed:24498420).;Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Self-association induces phosphorylation. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity. Phosphorylated by LMTK3 in vitro.;Ubiquitinated; regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation (PubMed:21602804, PubMed:28068668). Deubiquitinated by OTUB1 (PubMed:19383985).	Belongs to the nuclear hormone receptor family. NR3 subfamily.	Endocrine and other factor-regulated calcium reabsorption;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Nuclear signaling by ERBB4;Nuclear Receptor transcription pathway;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Ovarian tumor domain proteases;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;Regulation of RUNX2 expression and activity;RUNX1 regulates estrogen receptor mediated transcription;RUNX1 regulates transcription of genes involved in WNT signaling;Estrogen-dependent gene expression;SUMOylation of intracellular receptors;ESR-mediated signaling;Extra-nuclear estrogen signaling	PE1	6
+NX_P03886	NADH-ubiquinone oxidoreductase chain 1	318	35661	6.11	8	Mitochondrion inner membrane	Diabetes mellitus, non-insulin-dependent;Leber hereditary optic neuropathy;Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome;Alzheimer disease mitochondrial	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).	NA	Belongs to the complex I subunit 1 family.	Oxidative phosphorylation;Metabolic pathways;Parkinson's disease;Respiratory electron transport;Complex I biogenesis	PE1	MT
+NX_P03891	NADH-ubiquinone oxidoreductase chain 2	347	38961	9.84	10	Mitochondrion inner membrane	Leber hereditary optic neuropathy;Alzheimer disease mitochondrial	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).	NA	Belongs to the complex I subunit 2 family.	Oxidative phosphorylation;Metabolic pathways;Parkinson's disease;Respiratory electron transport;Complex I biogenesis	PE1	MT
+NX_P03897	NADH-ubiquinone oxidoreductase chain 3	115	13186	4.45	3	Mitochondrion membrane;Cytosol	Leigh syndrome;Mitochondrial complex I deficiency, mitochondrial type 1	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).	NA	Belongs to the complex I subunit 3 family.	Oxidative phosphorylation;Metabolic pathways;Parkinson's disease;Respiratory electron transport;Complex I biogenesis	PE1	MT
+NX_P03901	NADH-ubiquinone oxidoreductase chain 4L	98	10741	5.73	3	Mitochondrion membrane;Mitochondrion	Leber hereditary optic neuropathy	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).	NA	Belongs to the complex I subunit 4L family.	Oxidative phosphorylation;Metabolic pathways;Parkinson's disease	PE1	MT
+NX_P03905	NADH-ubiquinone oxidoreductase chain 4	459	51581	9.4	11	Mitochondrion membrane	Leber hereditary optic neuropathy with dystonia;Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome;Leber hereditary optic neuropathy	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).	NA	Belongs to the complex I subunit 4 family.	Oxidative phosphorylation;Metabolic pathways;Parkinson's disease;Respiratory electron transport;Complex I biogenesis	PE1	MT
+NX_P03915	NADH-ubiquinone oxidoreductase chain 5	603	67027	9.14	15	Mitochondrion inner membrane	Leber hereditary optic neuropathy;Leigh syndrome;Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).	NA	Belongs to the complex I subunit 5 family.	Oxidative phosphorylation;Metabolic pathways;Parkinson's disease;Respiratory electron transport;Complex I biogenesis	PE1	MT
+NX_P03923	NADH-ubiquinone oxidoreductase chain 6	174	18622	4.18	6	Mitochondrion membrane	Leber hereditary optic neuropathy;Leber hereditary optic neuropathy with dystonia;Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome;Leigh syndrome	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).	NA	Belongs to the complex I subunit 6 family.	Oxidative phosphorylation;Metabolic pathways;Parkinson's disease;Respiratory electron transport;Complex I biogenesis	PE1	MT
+NX_P03928	ATP synthase protein 8	68	7992	9.92	1	Mitochondrion membrane	Mitochondrial complex V deficiency, mitochondrial 2;Cardiomyopathy, infantile hypertrophic	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).	NA	Belongs to the ATPase protein 8 family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	MT
+NX_P03950	Angiogenin	147	16550	9.73	0	Secretory vesicle lumen;Secreted;Nucleolus;Nucleus;Cytoskeleton	Amyotrophic lateral sclerosis 9	Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.	NA	Belongs to the pancreatic ribonuclease family.	Adherens junctions interactions	PE1	14
+NX_P03951	Coagulation factor XI	625	70109	8.47	0	Cytoplasmic vesicle;Secreted	Factor XI deficiency	Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.	Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.;N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite.	Belongs to the peptidase S1 family. Plasma kallikrein subfamily.	Complement and coagulation cascades;Intrinsic Pathway of Fibrin Clot Formation	PE1	4
+NX_P03952	Plasma kallikrein	638	71370	8.6	0	Secreted	Prekallikrein deficiency	The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.	NA	Belongs to the peptidase S1 family. Plasma kallikrein subfamily.	Complement and coagulation cascades;Activation of Matrix Metalloproteinases;Intrinsic Pathway of Fibrin Clot Formation	PE1	4
+NX_P03956	Interstitial collagenase	469	54007	6.47	0	Cytoplasmic vesicle;Extracellular matrix	NA	Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369).	Tyrosine phosphorylated in platelets by PKDCC/VLK.;Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.	Belongs to the peptidase M10A family.	PPAR signaling pathway;Pathways in cancer;Bladder cancer;Rheumatoid arthritis;Degradation of the extracellular matrix;Collagen degradation;Basigin interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Activation of Matrix Metalloproteinases;Interleukin-4 and Interleukin-13 signaling	PE1	11
+NX_P03971	Muellerian-inhibiting factor	560	59195	7.04	0	Cytoplasmic vesicle;Cytosol;Secreted	Persistent Muellerian duct syndrome 1	This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.	NA	Belongs to the TGF-beta family.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Signaling by BMP	PE1	19
+NX_P03973	Antileukoproteinase	132	14326	9.11	0	Golgi apparatus;Secreted	NA	Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879).	NA	NA	Neutrophil degranulation	PE1	20
+NX_P03979	T cell receptor gamma variable 3	118	13664	8.97	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	7
+NX_P03986	T cell receptor gamma constant 2	189	21698	5.95	1	Cell membrane	NA	Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	7
+NX_P03999	Short-wave-sensitive opsin 1	348	39135	8.91	7	Photoreceptor inner segment;Photoreceptor outer segment;Membrane;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Tritan color blindness	Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (Probable). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (By similarity). Involved in ensuring correct abundance and localization of retinal membrane proteins (By similarity). May increase spectral sensitivity in dim light (By similarity).	Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	G alpha (i) signalling events;The retinoid cycle in cones (daylight vision);Opsins;Retinoid cycle disease events	PE1	7
+NX_P04000	Long-wave-sensitive opsin 1	364	40572	8.89	7	Membrane	Blue cone monochromacy;Colorblindness, partial, protan series	Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.	Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	G alpha (i) signalling events;The retinoid cycle in cones (daylight vision);Opsins;Retinoid cycle disease events	PE1	X
+NX_P04001	Medium-wave-sensitive opsin 1	364	40584	8.9	7	Cell membrane	Colorblindness, partial, deutan series;Cone dystrophy 5;Blue cone monochromacy	Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.	N-glycosylated (PubMed:30948514). O-glycosylated (PubMed:30948514).;Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.;OPN1MW is phosphorylated by GRK7	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	G alpha (i) signalling events;The retinoid cycle in cones (daylight vision);Opsins;Retinoid cycle disease events	PE1	X
+NX_P04003	C4b-binding protein alpha chain	597	67033	7.15	0	Secreted	NA	Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	NA	NA	Complement and coagulation cascades;Pertussis;Regulation of Complement cascade	PE1	1
+NX_P04004	Vitronectin	478	54306	5.55	0	Endoplasmic reticulum;Cytoplasmic vesicle;Extracellular space	NA	Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.;Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.	It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.;Phosphorylation sites are present in the extracellular medium.;Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.;N- and O-glycosylated.;Sulfated on 2 tyrosine residues.	NA	Focal adhesion;ECM-receptor interaction;Syndecan interactions;Integrin cell surface interactions;Regulation of Complement cascade;ECM proteoglycans;Molecules associated with elastic fibres	PE1	17
+NX_P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	888	97476	6.33	7	Endoplasmic reticulum membrane	NA	Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.	N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.;Undergoes sterol-mediated ubiquitination and ER-associated degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1. This INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78 or RNF145, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.	Belongs to the HMG-CoA reductase family.	Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.;Terpenoid backbone biosynthesis;Metabolic pathways;Bile secretion;PPARA activates gene expression;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	5
+NX_P04040	Catalase	527	59756	6.9	0	Peroxisome;Cytoplasmic vesicle	Acatalasemia	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.	The N-terminus is blocked.	Belongs to the catalase family.	Tryptophan metabolism;Metabolic pathways;Peroxisome;Amyotrophic lateral sclerosis (ALS);Detoxification of Reactive Oxygen Species;Neutrophil degranulation;Peroxisomal protein import;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	11
+NX_P04049	RAF proto-oncogene serine/threonine-protein kinase	648	73052	9.33	0	Cytoplasm;Nucleus speckle;Mitochondrion;Cell membrane;Nucleus	LEOPARD syndrome 2;Noonan syndrome 5;Cardiomyopathy, dilated 1NN	Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.	Methylated at Arg-563 in response to EGF treatment. This modification leads to destabilization of the protein, possibly through proteasomal degradation.;Phosphorylation at Thr-269, Ser-338, Tyr-341, Thr-491 and Ser-494 results in its activation. Phosphorylation at Ser-29, Ser-43, Ser-289, Ser-296, Ser-301 and Ser-642 by MAPK1/ERK2 results in its inactivation. Phosphorylation at Ser-259 induces the interaction with YWHAZ and inactivates kinase activity. Dephosphorylation of Ser-259 by the complex containing protein phosphatase 1, SHOC2 and M-Ras/MRAS relieves inactivation, leading to stimulate RAF1 activity. Phosphorylation at Ser-338 by PAK1 and PAK5 and Ser-339 by PAK1 is required for its mitochondrial localization. Phosphorylation at Ser-621 in response to growth factor treatment stabilizes the protein, possibly by preventing proteasomal degradation. Phosphorylation at Ser-289, Ser-296, Ser-301, Ser-338 and Ser-621 are somehow linked to the methylation potential of cells. Treatment of cells with HGF in the presence of the methylation inhibitor 5'-methylthioadenosine (MTA) results in increased phosphorylation at Ser-338 and Ser-621 and decreased phosphorylation at Ser-296, Ser-301 and Ser-338. Dephosphorylation at Ser-338 by PPP5C results in an activity decrease.;RAF1 is phosphorylated by PDGFRB (Phosphotyrosine:PTM-0255);RAF1 is phosphorylated by JAK2 (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Focal adhesion;Gap junction;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Long-term potentiation;Neurotrophin signaling pathway;Long-term depression;Regulation of actin cytoskeleton;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Tuberculosis;Hepatitis C;Influenza A;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;Stimuli-sensing channels;Negative regulation of MAPK pathway;RAF activation;MAP2K and MAPK activation;CD209 (DC-SIGN) signaling;GP1b-IX-V activation signalling;Negative feedback regulation of MAPK pathway;Rap1 signalling;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	3
+NX_P04053	DNA nucleotidylexotransferase	509	58536	8.66	0	Nucleoplasm;Cytosol;Nucleus	NA	Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.	NA	Belongs to the DNA polymerase type-X family.	Non-homologous end-joining;Hematopoietic cell lineage	PE1	10
+NX_P04054	Phospholipase A2	148	16360	8.16	0	Secreted	NA	PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.	Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.	Belongs to the phospholipase A2 family.	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI	PE1	12
+NX_P04062	Lysosomal acid glucosylceramidase	536	59716	7.29	0	Lysosome membrane	Parkinson disease;Gaucher disease 3C;Gaucher disease;Gaucher disease perinatal lethal;Gaucher disease 2;Gaucher disease 3;Gaucher disease 1	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose (PubMed:9201993, PubMed:24211208). Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation (PubMed:19279011). Also plays a role in cholesterol metabolism (PubMed:24211208, PubMed:26724485). May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol (PubMed:24211208, PubMed:26724485). The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction (PubMed:24211208). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (PubMed:26724485). Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol (PubMed:24211208, PubMed:26724485).	NA	Belongs to the glycosyl hydrolase 30 family.	Steroid metabolism; cholesterol metabolism.;Sphingolipid metabolism.;Other glycan degradation;Sphingolipid metabolism;Metabolic pathways;Lysosome;Glycosphingolipid metabolism;Association of TriC/CCT with target proteins during biosynthesis	PE1	1
+NX_P04066	Tissue alpha-L-fucosidase	466	53689	6.37	0	Lysosome	Fucosidosis	Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	NA	Belongs to the glycosyl hydrolase 29 family.	Other glycan degradation;Lysosome;Reactions specific to the complex N-glycan synthesis pathway;Neutrophil degranulation	PE1	1
+NX_P04070	Vitamin K-dependent protein C	461	52071	5.85	0	Endoplasmic reticulum;Golgi apparatus;Secreted	Thrombophilia due to protein C deficiency, autosomal recessive;Thrombophilia due to protein C deficiency, autosomal dominant	Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).	The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.;The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.;N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.;May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Intrinsic Pathway of Fibrin Clot Formation;Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins;Post-translational protein phosphorylation	PE1	2
+NX_P04075	Fructose-bisphosphate aldolase A	364	39420	8.3	0	I band;Cytosol;M line;Nucleus	Glycogen storage disease 12	Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).	ALDOA is phosphorylated by MAPK3	Belongs to the class I fructose-bisphosphate aldolase family.	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Fructose and mannose metabolism;Metabolic pathways;Glycolysis;Platelet degranulation;Gluconeogenesis;Neutrophil degranulation	PE1	16
+NX_P04080	Cystatin-B	98	11140	6.96	0	Nucleolus;Cytoplasm;Cytosol;Nucleus	Epilepsy, progressive myoclonic 1	This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.	NA	Belongs to the cystatin family.	Neutrophil degranulation	PE1	21
+NX_P04083	Annexin A1	346	38714	6.57	0	Extracellular exosome;Cytoplasm;Lateral cell membrane;Cell membrane;Secretory vesicle lumen;Apical cell membrane;Early endosome;Basolateral cell membrane;Endosome membrane;Cilium;Secreted;Membrane;Cytoplasmic vesicle membrane;Nucleoplasm;Phagocytic cup;Extracellular space;Cytosol;Nucleus	NA	Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).	Sumoylated.;Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504).	Belongs to the annexin family.	G alpha (i) signalling events;G alpha (q) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands;Smooth Muscle Contraction;Interleukin-4 and Interleukin-13 signaling	PE1	9
+NX_P04085	Platelet-derived growth factor subunit A	211	24043	9.52	0	Cytoplasmic vesicle;Centriolar satellite;Secreted	NA	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).	NA	Belongs to the PDGF/VEGF growth factor family.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Focal adhesion;Gap junction;Regulation of actin cytoskeleton;HTLV-I infection;Pathways in cancer;Glioma;Prostate cancer;Melanoma;RAF/MAP kinase cascade;Signaling by PDGF;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Platelet degranulation;Non-integrin membrane-ECM interactions;Downstream signal transduction;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	7
+NX_P04090	Prorelaxin H2	185	21043	8.88	0	Secreted	NA	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.	NA	Belongs to the insulin family.	Relaxin receptors;G alpha (s) signalling events	PE1	9
+NX_P04114	Apolipoprotein B-100	4563	515605	6.58	0	Cytoplasmic vesicle;Cytosol;Cytoplasm;Secreted	Familial ligand-defective apolipoprotein B-100;Hypobetalipoproteinemia, familial, 1	Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.	Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.	NA	Fat digestion and absorption;Vitamin digestion and absorption;Retinoid metabolism and transport;Cell surface interactions at the vascular wall;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Scavenging by Class A Receptors;Platelet sensitization by LDL;Scavenging by Class F Receptors;Scavenging by Class B Receptors;Scavenging by Class H Receptors;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Regulation of TLR by endogenous ligand;VLDL assembly;Post-translational protein phosphorylation;LDL clearance;Chylomicron clearance;LDL remodeling;Chylomicron remodeling;Chylomicron assembly;VLDL clearance	PE1	2
+NX_P04118	Colipase	112	11954	7.48	0	Secreted	NA	Enterostatin has a biological activity as a satiety signal.;Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.	NA	Belongs to the colipase family.	Fat digestion and absorption;Retinoid metabolism and transport;Digestion of dietary lipid	PE1	6
+NX_P04141	Granulocyte-macrophage colony-stimulating factor	144	16295	5.21	0	Cytoplasmic vesicle;Secreted	NA	Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.	NA	Belongs to the GM-CSF family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Salmonella infection;Amoebiasis;HTLV-I infection;Rheumatoid arthritis;RAF/MAP kinase cascade;Interleukin receptor SHC signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling;Interleukin-10 signaling;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	PE1	5
+NX_P04150	Glucocorticoid receptor	777	85659	6	0	Cytoplasm;Mitochondrion;Nucleoplasm;Centrosome;Cytosol;Spindle;Nucleus	Glucocorticoid resistance, generalized	Has transcriptional activation activity.;Has transcriptional activation activity.;Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127).;Has transcriptional activation activity.;More effective than isoform Alpha in transcriptional activation, but not repression activity.;Has transcriptional activation activity.;Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).;Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903).;Acts as a dominant negative inhibitor of isoform Alpha (PubMed:7769088, PubMed:8621628, PubMed:20484466). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253).;Has transcriptional activation and repression activity (PubMed:15866175, PubMed:19248771, PubMed:20484466, PubMed:23820903, PubMed:11435610, PubMed:15769988, PubMed:17635946, PubMed:19141540, PubMed:21664385). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity).;Has transcriptional activation activity.;Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).	Increased proteasome-mediated degradation in response to glucocorticoids (PubMed:11555652).;Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.;Sumoylation at Lys-277 and Lys-293 negatively regulates its transcriptional activity (PubMed:12144530). Sumoylation at Lys-703 positively regulates its transcriptional activity in the presence of RWDD3 (By similarity). Sumoylation at Lys-277 and Lys-293 is dispensable whereas sumoylation at Lys-703 is critical for the stimulatory effect of RWDD3 on its transcriptional activity (By similarity). Heat shock increases sumoylation in a RWDD3-dependent manner (By similarity).;Appears to be more susceptible to proteolytic degradation than isoform Alpha (PubMed:11435610).;Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity.;Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203, Ser-226 and Ser-404-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear (PubMed:12000743, PubMed:18838540). Phosphorylation at Ser-211 increases transcriptional activity (PubMed:12000743, PubMed:18483179). Phosphorylation at Ser-203, Ser-226 and Ser-404 decreases signaling capacity (PubMed:12000743, PubMed:18483179, PubMed:18838540). Phosphorylation at Ser-404 may protect from glucocorticoid-induced apoptosis (PubMed:18838540). Phosphorylation at Ser-203 and Ser-211 is not required in regulation of chromosome segregation (PubMed:25847991). May be dephosphorylated by PPP5C, attenuates NR3C1 action (By similarity).	Belongs to the nuclear hormone receptor family. NR3 subfamily.	Neuroactive ligand-receptor interaction;Circadian Clock;Nuclear Receptor transcription pathway;PTK6 Expression;HSP90 chaperone cycle for steroid hormone receptors (SHR);Regulation of RUNX2 expression and activity;SUMOylation of intracellular receptors;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	5
+NX_P04155	Trefoil factor 1	84	9150	4.29	0	Secreted	NA	Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.	NA	NA	Estrogen-dependent gene expression	PE1	21
+NX_P04156	Major prion protein	253	27661	9.13	0	Golgi apparatus;Cell membrane;Nucleus membrane;Cytoplasmic vesicle;Cytosol	Fatal familial insomnia;Huntington disease-like 1;Gerstmann-Straussler disease;Spongiform encephalopathy with neuropsychiatric features;Kuru;Creutzfeldt-Jakob disease	Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).	The glycosylation pattern (the amount of mono-, di- and non-glycosylated forms or glycoforms) seems to differ in normal and CJD prion.	Belongs to the prion family.	Prion diseases;NCAM1 interactions;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	20
+NX_P04179	Superoxide dismutase [Mn], mitochondrial	222	24750	8.35	0	Mitochondrion matrix	Microvascular complications of diabetes 6	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.	Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).;Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.;Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.	Belongs to the iron/manganese superoxide dismutase family.	Peroxisome;Huntington's disease;Detoxification of Reactive Oxygen Species;Transcriptional activation of mitochondrial biogenesis;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	6
+NX_P04180	Phosphatidylcholine-sterol acyltransferase	440	49578	5.71	0	Nucleoplasm;Secreted	Fish-eye disease;Lecithin-cholesterol acyltransferase deficiency	Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751).	O- and N-glycosylated. O-glycosylation on Thr-431 and Ser-433 consists of sialylated galactose beta 1-->3N-acetylgalactosamine structures. N-glycosylated sites contain sialylated triantennary and/or biantennary complex structures.	Belongs to the AB hydrolase superfamily. Lipase family.	Glycerophospholipid metabolism;HDL remodeling	PE1	16
+NX_P04181	Ornithine aminotransferase, mitochondrial	439	48535	6.57	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	Hyperornithinemia with gyrate atrophy of choroid and retina	NA	NA	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.;Arginine and proline metabolism;Metabolic pathways;Glutamate and glutamine metabolism	PE1	10
+NX_P04183	Thymidine kinase, cytosolic	234	25469	8.85	0	Cytoplasm	NA	NA	Phosphorylated on Ser-13 in mitosis.	Belongs to the thymidine kinase family.	Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;G1/S-Specific Transcription;Pyrimidine salvage	PE1	17
+NX_P04196	Histidine-rich glycoprotein	525	59578	7.09	0	Secreted	Thrombophilia due to histidine-rich glycoprotein deficiency	Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis.	N-glycosylated.;Proteolytic cleavage produces several HRG fragments which are mostly disulfide-linked and, therefore, not released. Cleavage by plasmin is inhibited in the presence of heparin, zinc ions or in an acidic environment. Cleavage reduces binding of HRG to heparan sulfate, but enhances the ability of HRG to bind and tether plasminogen to the cell surface. On platelet activation, releases a 33 kDa antiangiogenic peptide which encompasses the HRR. Also cleaved in the C-terminal by plasmin.	NA	Platelet degranulation;Dissolution of Fibrin Clot	PE1	3
+NX_P04198	N-myc proto-oncogene protein	464	49561	5.45	0	Nucleoplasm;Nucleolus;Nucleus	Feingold syndrome 1	Positively regulates the transcription of MYCNOS in neuroblastoma cells.	Phosphorylated by GSK3-beta which may promote its degradation (PubMed:24391509). Phosphorylated by AURKA (PubMed:27837025).	NA	NA	PE1	2
+NX_P04201	Proto-oncogene Mas	325	37465	8.9	7	Cell membrane	NA	Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Renin-angiotensin system	PE1	6
+NX_P04211	Immunoglobulin lambda variable 7-43	117	12451	6.52	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P04216	Thy-1 membrane glycoprotein	161	17935	8.96	0	Endoplasmic reticulum;Nucleoplasm;Cell membrane	NA	May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.	NA	NA	Leukocyte transendothelial migration;Post-translational modification: synthesis of GPI-anchored proteins	PE1	11
+NX_P04217	Alpha-1B-glycoprotein	495	54254	5.56	0	Secreted	NA	NA	NA	NA	Platelet degranulation;Neutrophil degranulation	PE1	19
+NX_P04229	HLA class II histocompatibility antigen, DRB1-1 beta chain	266	29914	7.61	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;Lysosome membrane;trans-Golgi network membrane;Late endosome membrane	Sarcoidosis 1	(Microbial infection) Acts as a receptor for Epstein-Barr virus on lymphocytes.;Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P04233	HLA class II histocompatibility antigen gamma chain	296	33516	8.72	1	trans-Golgi network;Golgi apparatus;Endoplasmic reticulum membrane;Cell membrane;Endosome;Lysosome	NA	Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.	N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.	NA	Antigen processing and presentation;Tuberculosis;Herpes simplex infection;MHC class II antigen presentation;Cell surface interactions at the vascular wall	PE1	5
+NX_P04234	T-cell surface glycoprotein CD3 delta chain	171	18930	5.3	1	Cell membrane	Immunodeficiency 19	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456).	Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.	NA	Hematopoietic cell lineage;T cell receptor signaling pathway;Chagas disease (American trypanosomiasis);Measles;HTLV-I infection;Primary immunodeficiency;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	11
+NX_P04259	Keratin, type II cytoskeletal 6B	564	60067	8.09	0	NA	Pachyonychia congenita 4	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_P04264	Keratin, type II cytoskeletal 1	644	66039	8.15	0	Cell membrane	Keratoderma, palmoplantar, striate 3;Ichthyosis hystrix, Curth-Macklin type;Keratoderma, palmoplantar, non-epidermolytic;Ichthyosis annular epidermolytic;Epidermolytic hyperkeratosis	May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.	Undergoes deimination of some arginine residues (citrullination).	Belongs to the intermediate filament family.	Neutrophil degranulation;Formation of the cornified envelope;Keratinization	PE1	12
+NX_P04271	Protein S100-B	92	10713	4.57	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.	NA	Belongs to the S-100 family.	Advanced glycosylation endproduct receptor signaling;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;Nuclear signaling by ERBB4	PE1	21
+NX_P04275	von Willebrand factor	2813	309265	5.29	0	Extracellular matrix;Secreted	von Willebrand disease 2;von Willebrand disease 1;von Willebrand disease 3	Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.	N- and O-glycosylated.;All cysteine residues are involved in intrachain or interchain disulfide bonds.	NA	Focal adhesion;ECM-receptor interaction;Complement and coagulation cascades;MAP2K and MAPK activation;Integrin cell surface interactions;Platelet degranulation;Platelet Adhesion to exposed collagen;Integrin alphaIIb beta3 signaling;Intrinsic Pathway of Fibrin Clot Formation;GP1b-IX-V activation signalling;Platelet Aggregation (Plug Formation);GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	12
+NX_P04278	Sex hormone-binding globulin	402	43779	6.22	0	Secreted	NA	Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.	Variant Asn-356 contains one N-linked (GlcNAc...) at position 356.	NA	NA	PE1	17
+NX_P04279	Semenogelin-1	462	52131	9.3	0	Secreted	NA	Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.;Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.	Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa.;Transglutaminase substrate.	Belongs to the semenogelin family.	Amyloid fiber formation;Antimicrobial peptides	PE1	20
+NX_P04280	Basic salivary proline-rich protein 1	392	38562	11.22	0	Secreted	NA	NA	Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine. The endoprotease may be of microbial origin.;O-glycosylated. O-glycosylation on Ser-87 is prevalent in head and neck cancer patients. O-Glycosylation on Ser-330 has a 5 times prevalence in head and neck cancers.;Pyroglutamate formation occurs on terminal Gln residues of cleaved peptides. Besides on the N-terminal of mature PBR1, pyroglutamate formation found on at least Gln-58.	NA	Salivary secretion	PE1	12
+NX_P04350	Tubulin beta-4A chain	444	49586	4.78	0	Cytoskeleton	Leukodystrophy, hypomyelinating, 6;Dystonia 4, torsion, autosomal dominant	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;MHC class II antigen presentation;Intraflagellar transport;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;AURKA Activation by TPX2;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	19
+NX_P04406	Glyceraldehyde-3-phosphate dehydrogenase	335	36053	8.57	0	Cytoplasm;Cell membrane;Nucleus membrane;Membrane;Cytoplasmic vesicle;Cytosol;Perinuclear region;Nucleus;Cytoskeleton	NA	Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.	Succination of Cys-152 and Cys-247 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits glyceraldehyde-3-phosphate dehydrogenase activity. Fumarate concentration as well as succination of cysteine residues in GAPDH is significantly increased in muscle of diabetic mammals. It was proposed that the S-(2-succinyl)cysteine chemical modification may be a useful biomarker of mitochondrial and oxidative stress in diabetes and that succination of GAPDH and other thiol proteins by fumarate may contribute to the metabolic changes underlying the development of diabetes complications.;ISGylated.;Sulfhydration at Cys-152 increases catalytic activity.;Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation. Such aggregates can be observed in vivo in the affected tissues of patients with Alzheimer disease or alcoholic liver cirrhosis, or in cell cultures during necrosis. Oxidation at Met-46 may play a pivotal role in the formation of these insoluble structures. This modification has been detected in vitro following treatment with free radical donor (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide. It has been proposed to destabilize nearby residues, increasing the likelihood of secondary oxidative damages, including oxidation of Tyr-45 and Met-105. This cascade of oxidations may augment GAPDH misfolding, leading to intermolecular disulfide cross-linking and aggregation.;S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus (By similarity). S-nitrosylation of Cys-247 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity.;GAPDH is phosphorylated by PRKCI (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);GAPDH is phosphorylated by CAMK2B	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.;Glycolysis / Gluconeogenesis;Metabolic pathways;Alzheimer's disease;Glycolysis;Gluconeogenesis	PE1	12
+NX_P04424	Argininosuccinate lyase	464	51658	6.04	0	Cytosol	Argininosuccinic aciduria	NA	Acetylation modifies enzyme activity in response to alterations of extracellular nutrient availability. Acetylation increased with trichostin A (TSA) or with nicotinamide (NAM). Glucose increases acetylation by about a factor of 3 with decreasing enzyme activity. Acetylation on Lys-288 is decreased on the addition of extra amino acids resulting in activation of enzyme activity.	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.;Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1.;Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;Metabolic pathways;Urea cycle	PE1	7
+NX_P04430	Immunoglobulin kappa variable 1-16	117	12618	8.4	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P04432	Immunoglobulin kappa variable 1D-39	117	12737	8.91	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P04433	Immunoglobulin kappa variable 3-11	115	12575	4.85	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P04435	T cell receptor beta variable 7-9	115	13107	7.7	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	7
+NX_P04437	T cell receptor alpha variable 29/delta variable 5	119	13438	6.03	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	14
+NX_P04439	HLA class I histocompatibility antigen, A alpha chain	365	40841	5.66	1	Golgi apparatus;Endoplasmic reticulum membrane;Cell membrane	Diabetes mellitus, insulin-dependent	Allele A*32:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response.;Allele A*68:01: Presents viral epitopes derived from IAV NP (KTGGPIYKR) and HIV-1 tat (ITKGLGISYGR), having a common signature motif namely, Val or Thr at position 2 and positively charged residues Arg or Lys at C-terminal anchor.;Allele A*74:01: Presents immunodominant HIV-1 epitopes derived from gag-pol (GQMVHQAISPR, QIYPGIKVR) and rev (RQIHSISER), carrying an aliphatic residue at position 2 and Arg anchor residue at C-terminal. May contribute to viral load control in chronic HIV-1 infection.;Allele A*11:01: Presents several immunodominant epitopes derived from HIV-1 gag-pol and HHV-4 EBNA4, containing the peptide motif with Val, Ile, Thr, Leu, Tyr or Phe at position 2 and Lys anchor residue at C-terminal. Important in the control of HIV-1, EBV and HBV infections.;Allele A*23:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response.;Allele A*29:02: Presents peptides having a common motif, namely a Glu residue at position 2 and Tyr or Leu anchor residues at C-terminal.;Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:2456340, PubMed:2784196, PubMed:1402688, PubMed:7504010, PubMed:9862734, PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:15893615, PubMed:17189421, PubMed:19543285, PubMed:21498667, PubMed:24192765, PubMed:7694806, PubMed:24395804, PubMed:28250417). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728, PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17189421, PubMed:20364150, PubMed:17079320, PubMed:26929325, PubMed:27049119). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734).;Allele A*24:02: Presents viral epitopes derived from HIV-1 nef (RYPLTFGWCF), EBV lytic- and latent-cycle antigens BRLF1 (TYPVLEEMF), BMLF1 (DYNFVKQLF) and LMP2 (IYVLVMLVL), SARS-CoV nucleocapsid/N (QFKDNVILL), as well as tumor peptide antigens including PRAME (LYVDSLFFL), all sharing a common signature motif, namely an aromatic residue Tyr or Phe at position 2 and a nonhydrophobic anchor residue Phe, Leu or Iso at C-terminal (PubMed:9047241, PubMed:12393434, PubMed:24192765, PubMed:20844028). Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response (PubMed:17182537, PubMed:18502829).;Allele A*01:01: Presents a restricted peptide repertoire including viral epitopes derived from IAV NP/nucleoprotein (CTELKLSDY), IAV PB1/polymerase basic protein 1 (VSDGGPNLY), HAdV-11 capsid L3/hexon protein (LTDLGQNLLY) as well as tumor peptide antigens including MAGE1 (EADPTGHSY), MAGEA3 (EVDPIGHLY) and WT1 (TSEKRPFMCAY), all having in common a canonical motif with a negatively charged Asp or Glu residue at position 3 and a Tyr anchor residue at C-terminal (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:20364150, PubMed:25880248, PubMed:30530481, PubMed:19177349, PubMed:24395804, PubMed:26758806). A number of HLA-A*01:01-restricted peptides carry a post-translational modification with oxidation and N-terminal acetylation being the most frequent (PubMed:25880248). Fails to present highly immunogenic peptides from the EBV latent antigens (PubMed:18779413).;Allele A*02:01: A major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at C-terminal anchors.;Allele A*03:01: Presents viral epitopes derived from IAV NP (ILRGSVAHK), HIV-1 nef (QVPLRPMTYK), HIV-1 gag-pol (AIFQSSMTK) as well as tumor peptide antigens including PMEL (LIYRRRLMK), NODAL (HAYIQSLLK), TRP-2 (RMYNMVPFF), all having in common hydrophobic amino acids at position 2 and Lys or Arg anchor residues at C-terminal (PubMed:7504010, PubMed:7679507, PubMed:9862734, PubMed:19543285, PubMed:21943705, PubMed:2456340). May also display spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119).;Allele A*26:01: Presents several epitopes derived from HIV-1 gag-pol (EVIPMFSAL, ETKLGKAGY) and env (LVSDGGPNLY), carrying as anchor residues preferentially Glu at position 1, Val or Thr at position 2 and Tyr at C-terminal.	N-linked glycosylation at Asn-110.;(Microbial infection) Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system.	Belongs to the MHC class I family.	Endocytosis;Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Type I diabetes mellitus;HTLV-I infection;Herpes simplex infection;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;Viral myocarditis;ER-Phagosome pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Endosomal/Vacuolar pathway;Interferon gamma signaling;Interferon alpha/beta signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;E3 ubiquitin ligases ubiquitinate target proteins	PE1	6
+NX_P04440	HLA class II histocompatibility antigen, DP beta 1 chain	258	29159	8.83	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;Lysosome membrane;Cell junction;trans-Golgi network membrane;Nucleoplasm	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	NA	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P04553	Sperm protamine P1	51	6823	12.08	0	Nucleus;Chromosome	NA	Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.	Phosphorylated by SRPK1.;PRM1 is phosphorylated by SRPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protamine P1 family.	NA	PE1	16
+NX_P04554	Protamine-2	102	13051	11.9	0	Nucleus;Chromosome	NA	Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.	Proteolytic processing into mature chains is required for histone eviction during spermatogenesis. Transition proteins (TNP1 and TNP2) are required for processing.	Belongs to the protamine P2 family.	NA	PE1	16
+NX_P04626	Receptor tyrosine-protein kinase erbB-2	1255	137910	5.58	1	Cytoplasm;Cell membrane;Early endosome;Cytosol;Perinuclear region;Nucleus	Ovarian cancer;Glioma;Gastric cancer;Lung cancer	In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.;Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.	Autophosphorylated. Autophosphorylation occurs in trans, i.e. One subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues (PubMed:27134172). Signaling via SEMA4C promotes phosphorylation at Tyr-1248 (PubMed:17554007). Dephosphorylated by PTPN12 (PubMed:27134172).	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.	ErbB signaling pathway;Calcium signaling pathway;Focal adhesion;Adherens junction;Pathways in cancer;Pancreatic cancer;Endometrial cancer;Prostate cancer;Bladder cancer;Non-small cell lung cancer;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Signaling by ERBB2;SHC1 events in ERBB2 signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Sema4D induced cell migration and growth-cone collapse;GRB7 events in ERBB2 signaling;Downregulation of ERBB2:ERBB3 signaling;PLCG1 events in ERBB2 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;Downregulation of ERBB2 signaling	PE1	17
+NX_P04628	Proto-oncogene Wnt-1	370	40982	9.28	0	Extracellular matrix;Secreted	Osteogenesis imperfecta 15;Osteoporosis	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646).	Palmitoleoylation is required for efficient binding to frizzled receptors. Palmitoleoylation is necessary for proper trafficking to cell surface (Probable). Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors);TCF dependent signaling in response to WNT;PCP/CE pathway;Transcriptional regulation of white adipocyte differentiation;Disassembly of the destruction complex and recruitment of AXIN to the membrane	PE1	12
+NX_P04629	High affinity nerve growth factor receptor	796	87497	6.17	1	Cell membrane;Recycling endosome membrane;Early endosome membrane;Cytoplasmic vesicle;Cytosol;Late endosome membrane	Congenital insensitivity to pain with anhidrosis	Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation.;Promotes angiogenesis and has oncogenic activity when overexpressed.;Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.	Are N-glycosylated.;Ligand-mediated autophosphorylation (PubMed:2927393, PubMed:1281417, PubMed:15488758, PubMed:7510697, PubMed:8155326, PubMed:8325889, PubMed:27676246, PubMed:28177573). Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-496 mediates interaction and phosphorylation of SHC1 (PubMed:15488758, PubMed:7510697, PubMed:8155326, PubMed:8325889).;Ubiquitinated (PubMed:27445338). Undergoes polyubiquitination upon activation; regulated by NGFR (PubMed:27445338). Ubiquitination by NEDD4L leads to degradation (PubMed:27445338). Ubiquitination regulates the internalization of the receptor (By similarity).;N-glycosylated (PubMed:2927393).	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	MAPK signaling pathway;Endocytosis;Apoptosis;Neurotrophin signaling pathway;Pathways in cancer;Thyroid cancer;Signalling to p38 via RIT and RIN;Retrograde neurotrophin signalling;ARMS-mediated activation;Signalling to RAS;Frs2-mediated activation;PI3K/AKT activation;NGF-independant TRKA activation;PLC-gamma1 signalling;TRKA activation by NGF;Signalling to STAT3	PE1	1
+NX_P04632	Calpain small subunit 1	268	28316	5.05	0	Nucleoplasm;Cytoplasm;Cytosol;Cell membrane	NA	Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.	NA	NA	Degradation of the extracellular matrix;Formation of the cornified envelope;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	PE1	19
+NX_P04637	Cellular tumor antigen p53	393	43653	6.33	0	Cytoplasm;Mitochondrion matrix;Nucleoplasm;Endoplasmic reticulum;PML body;Nucleus	Bone marrow failure syndrome 5;Lung cancer;Li-Fraumeni syndrome;Squamous cell carcinoma of the head and neck;Esophageal cancer;Basal cell carcinoma 7;Papilloma of choroid plexus;Adrenocortical carcinoma	Inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).;Enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters.;Suppresses transactivation activity and impairs growth suppression mediated by isoform 1.;Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.	Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the AC form of PP2A.;May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line.;Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9.;Is monoubiquitinated in an MDM2-independent manner (PubMed:15340061). Ubiquitinated by COP1, which leads to proteasomal degradation (PubMed:19837670). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (PubMed:25732823). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity).;Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation (PubMed:10722742, PubMed:12810724, PubMed:15340061, PubMed:17170702, PubMed:19880522). Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:10722742, PubMed:12810724, PubMed:20173098). Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation (PubMed:19536131). Deubiquitinated by USP10, leading to its stabilization (PubMed:20096447). Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation (PubMed:19556538). Ubiquitination by TOPORS induces degradation (PubMed:19473992). Deubiquitination by USP7, leading to stabilization (PubMed:15053880).;Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation (PubMed:15525938, PubMed:16415881). Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity (PubMed:17108971). Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370 (PubMed:17108971). Dimethylated at Lys-373 by EHMT1 and EHMT2 (PubMed:20118233). Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity (PubMed:17707234). Dimethylation at Lys-370 and Lys-382 diminishes p53 ubiquitination, through stabilizing association with the methyl reader PHF20 (PubMed:22864287). Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (PubMed:17805299). Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (PubMed:19011621).;Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity). Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by VRK1. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Phosphorylated on Ser-15 upon ultraviolet irradiation; which is enhanced by interaction with BANP. Phosphorylated by NUAK1 at Ser-15 and Ser-392; was initially thought to be mediated by STK11/LKB1 but it was later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream NUAK1 (PubMed:21317932). It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction in ubiquitination by MDM2 and an increase in acetylation by EP300. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage.;Acetylated. Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner.;TP53 is phosphorylated by CDK7;TP53 is phosphorylated by CHEK2;TP53 is phosphorylated by CHEK1	Belongs to the p53 family.	MAPK signaling pathway;Cell cycle;p53 signaling pathway;Apoptosis;Wnt signaling pathway;Neurotrophin signaling pathway;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Hepatitis C;Measles;HTLV-I infection;Herpes simplex infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Thyroid cancer;Basal cell carcinoma;Melanoma;Bladder cancer;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Autodegradation of the E3 ubiquitin ligase COP1;Factors involved in megakaryocyte development and platelet production;Oxidative Stress Induced Senescence;Formation of Senescence-Associated Heterochromatin Foci (SAHF);DNA Damage/Telomere Stress Induced Senescence;Association of TriC/CCT with target proteins during biosynthesis;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;TP53 Regulates Metabolic Genes;Oncogene Induced Senescence;Activation of PUMA and translocation to mitochondria;Stabilization of p53;Activation of NOXA and translocation to mitochondria;Transcriptional activation of cell cycle inhibitor p21;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Degradation;TP53 Regulates Transcription of Death Receptors and Ligands;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Regulation of TP53 Activity through Methylation;TP53 Regulates Transcription of Caspase Activators and Caspases;Regulation of TP53 Activity through Association with Co-factors;SUMOylation of transcription factors;Regulation of TP53 Expression;Ub-specific processing proteases;Ovarian tumor domain proteases;PI5P Regulates TP53 Acetylation;Interleukin-4 and Interleukin-13 signaling;RUNX3 regulates CDKN1A transcription;Regulation of PTEN gene transcription	PE1	17
+NX_P04731	Metallothionein-1A	61	6120	8.38	0	NA	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	NA	Belongs to the metallothionein superfamily. Type 1 family.	Metallothioneins bind metals	PE1	16
+NX_P04732	Metallothionein-1E	61	6014	8.38	0	Nucleoplasm	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	NA	Belongs to the metallothionein superfamily. Type 1 family.	Mineral absorption;Metallothioneins bind metals	PE1	16
+NX_P04733	Metallothionein-1F	61	6086	8.23	0	NA	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	NA	Belongs to the metallothionein superfamily. Type 1 family.	Mineral absorption;Metallothioneins bind metals	PE1	16
+NX_P04745	Alpha-amylase 1	511	57768	6.47	0	Secreted	NA	NA	NA	Belongs to the glycosyl hydrolase 13 family.	Starch and sucrose metabolism;Metabolic pathways;Salivary secretion;Carbohydrate digestion and absorption;Starch and sucrose metabolism;Metabolic pathways;Salivary secretion;Carbohydrate digestion and absorption;Starch and sucrose metabolism;Metabolic pathways;Salivary secretion;Carbohydrate digestion and absorption;Digestion of dietary carbohydrate	PE1	1
+NX_P04746	Pancreatic alpha-amylase	511	57707	6.6	0	Extracellular space	NA	NA	NA	Belongs to the glycosyl hydrolase 13 family.	Starch and sucrose metabolism;Metabolic pathways;Pancreatic secretion;Carbohydrate digestion and absorption;Digestion of dietary carbohydrate	PE1	1
+NX_P04792	Heat shock protein beta-1	205	22783	5.98	0	Cytoplasm;Cell membrane;Cytosol;Spindle;Nucleus	Neuronopathy, distal hereditary motor, 2B;Charcot-Marie-Tooth disease 2F	Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742).	Phosphorylated upon exposure to protein kinase C activators and heat shock (PubMed:8325890). Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (PubMed:1332886, PubMed:8093612, PubMed:19166925).	Belongs to the small heat shock protein (HSP20) family.	MAPK signaling pathway;VEGF signaling pathway;Amoebiasis;AUF1 (hnRNP D0) binds and destabilizes mRNA;MAPK6/MAPK4 signaling;VEGFA-VEGFR2 Pathway;Extra-nuclear estrogen signaling	PE1	7
+NX_P04798	Cytochrome P450 1A1	512	58165	8.61	0	Microsome membrane;Cytoplasm;Mitochondrion inner membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).	NA	Belongs to the cytochrome P450 family.	Cofactor metabolism; retinol metabolism.;Lipid metabolism; fatty acid metabolism.;Steroid hormone biosynthesis.;Steroid hormone biosynthesis;Tryptophan metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Metabolic pathways;Xenobiotics;PPARA activates gene expression;Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET);Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE);Biosynthesis of protectins	PE1	15
+NX_P04808	Prorelaxin H1	185	21146	8.97	0	Secreted	NA	Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.	NA	Belongs to the insulin family.	NA	PE1	9
+NX_P04818	Thymidylate synthase	313	35716	6.51	0	Cytoplasm;Mitochondrion;Mitochondrion matrix;Mitochondrion inner membrane;Nucleus	NA	Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.	NA	Belongs to the thymidylate synthase family.	Pyrimidine metabolism; dTTP biosynthesis.;Pyrimidine metabolism;One carbon pool by folate;Metabolic pathways;G1/S-Specific Transcription;Interconversion of nucleotide di- and triphosphates	PE1	18
+NX_P04839	Cytochrome b-245 heavy chain	570	65336	8.9	6	Cell membrane	Immunodeficiency 34;Granulomatous disease, chronic, X-linked	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.	Phosphorylated on Ser and Thr residues.;Glycosylated.;Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation.	NA	Phagosome;Osteoclast differentiation;Leukocyte transendothelial migration;Detoxification of Reactive Oxygen Species;VEGFA-VEGFR2 Pathway;ROS and RNS production in phagocytes;Cross-presentation of particulate exogenous antigens (phagosomes);RHO GTPases Activate NADPH Oxidases;Neutrophil degranulation	PE1	X
+NX_P04843	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	607	68569	5.96	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Melanosome	NA	Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.	NA	Belongs to the OST1 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation	PE1	3
+NX_P04844	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2	631	69284	5.44	3	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.	NA	Belongs to the SWP1 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation	PE1	20
+NX_P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	355	40451	5.34	0	Cytoplasm;Cell membrane;Membrane;Nucleoplasm;Centrosome;Cytosol	NA	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.;Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.	(Microbial infection) Deamidated at Gln-205 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.	Belongs to the G-alpha family. G(i/o/t/z) subfamily.	Chemokine signaling pathway;Axon guidance;Tight junction;Gap junction;Leukocyte transendothelial migration;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Long-term depression;Progesterone-mediated oocyte maturation;Melanogenesis;Gastric acid secretion;Pertussis;Chagas disease (American trypanosomiasis);Toxoplasmosis;G alpha (i) signalling events;G alpha (s) signalling events;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (z) signalling events;Regulation of insulin secretion;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling	PE1	3
+NX_P04908	Histone H2A type 1-B/E	130	14135	11.05	0	Nucleoplasm;Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.;Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Deiminated on Arg-4 in granulocytes upon calcium entry.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.	Belongs to the histone H2A family.	Systemic lupus erythematosus;Systemic lupus erythematosus;Transcriptional regulation by small RNAs;RMTs methylate histone arginines;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_P04920	Anion exchange protein 2	1241	137009	5.9	10	Membrane;Cytosol;Nucleus speckle;Cell membrane	NA	Plasma membrane anion exchange protein of wide distribution.	NA	Belongs to the anion exchanger (TC 2.A.31) family.	Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;Bicarbonate transporters	PE1	7
+NX_P04921	Glycophorin-C	128	13811	4.68	1	Cell membrane	NA	This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.	O-glycosylated with core 1 or possibly core 8 glycans.	Belongs to the glycophorin-C family.	Malaria;Cell surface interactions at the vascular wall	PE1	2
+NX_P05000	Interferon omega-1	195	22319	9.18	0	Secreted	NA	NA	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;RIG-I-like receptor signaling pathway;Jak-STAT signaling pathway	PE1	9
+NX_P05013	Interferon alpha-6	189	22141	6.9	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE1	9
+NX_P05014	Interferon alpha-4	189	21808	5.76	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE1	9
+NX_P05015	Interferon alpha-16	189	21711	6.31	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE2	9
+NX_P05019	Insulin-like growth factor I	195	21841	9.78	0	Secreted	Insulin-like growth factor I deficiency	The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309).	NA	Belongs to the insulin family.	Oocyte meiosis;p53 signaling pathway;mTOR signaling pathway;Focal adhesion;Long-term depression;Progesterone-mediated oocyte maturation;Aldosterone-regulated sodium reabsorption;Pathways in cancer;Glioma;Prostate cancer;Melanoma;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Synthesis, secretion, and deacylation of Ghrelin;IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	PE1	12
+NX_P05023	Sodium/potassium-transporting ATPase subunit alpha-1	1023	112896	5.33	10	Sarcolemma;Melanosome;Cell membrane	Hypomagnesemia, seizures, and mental retardation 2;Charcot-Marie-Tooth disease 2DD	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.	Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.	Cardiac muscle contraction;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Protein digestion and absorption;Bile secretion;Mineral absorption;Ion transport by P-type ATPases;Ion homeostasis	PE1	1
+NX_P05026	Sodium/potassium-transporting ATPase subunit beta-1	303	35061	8.74	1	Sarcolemma;Cell membrane	NA	Involved in cell adhesion and establishing epithelial cell polarity.;This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.	Glutathionylated.	Belongs to the X(+)/potassium ATPases subunit beta family.	Cardiac muscle contraction;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Protein digestion and absorption;Bile secretion;Mineral absorption;Ion transport by P-type ATPases;Basigin interactions;Ion homeostasis	PE1	1
+NX_P05060	Secretogranin-1	677	78276	5.02	0	Cytoplasmic vesicle;Secreted	NA	Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.	O-glycosylated.;Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).	Belongs to the chromogranin/secretogranin protein family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	20
+NX_P05062	Fructose-bisphosphate aldolase B	364	39473	8.01	0	Centriolar satellite	Hereditary fructose intolerance	NA	NA	Belongs to the class I fructose-bisphosphate aldolase family.	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Fructose and mannose metabolism;Metabolic pathways;Glycolysis;Gluconeogenesis;Fructose catabolism;Hereditary fructose intolerance	PE1	9
+NX_P05067	Amyloid-beta precursor protein	770	86943	4.73	1	Cytoplasm;Golgi apparatus;Cell membrane;Early endosome;Growth cone;Perikaryon;Secreted;Clathrin-coated pit;Membrane;Cell surface;Cytoplasmic vesicle;Nucleus	Cerebral amyloid angiopathy, APP-related;Alzheimer disease 1	The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.;N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).;Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain.;Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.;Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.	Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP).;Amyloid-beta peptides are degraded by IDE.;N-glycosylated (PubMed:2900137). N- and O-glycosylated. O-glycosylation on Ser and Thr residues with core 1 or possibly core 8 glycans. Partial tyrosine glycosylation (Tyr-681) is found on some minor, short amyloid-beta peptides (amyloid-beta 1-15, 1-16, 1-17, 1-18, 1-19 and 1-20) but not found on amyloid-beta protein 38, amyloid-beta protein 40 nor on amyloid-beta protein 42. Modification on a tyrosine is unusual and is more prevelant in AD patients. Glycans had Neu5AcHex(Neu5Ac)HexNAc-O-Tyr, Neu5AcNeu5AcHex(Neu5Ac)HexNAc-O-Tyr and O-AcNeu5AcNeu5AcHex(Neu5Ac)HexNAc-O-Tyr structures, where O-Ac is O-acetylation of Neu5Ac. Neu5AcNeu5Ac is most likely Neu5Ac 2,8Neu5Ac linked. O-glycosylations in the vicinity of the cleavage sites may influence the proteolytic processing. Appicans are L-APP isoforms with O-linked chondroitin sulfate.;Proteolytically cleaved by caspases during neuronal apoptosis. Cleavage at Asp-739 by either CASP6, CASP8 or CASP9 results in the production of the neurotoxic C31 peptide and the increased production of amyloid-beta peptides.;Proteolytically processed under normal cellular conditions. Cleavage either by alpha-secretase, beta-secretase or theta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, and the retention of corresponding membrane-anchored C-terminal fragments, C80, C83 and C99. Subsequent processing of C80 and C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is non-amyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid-beta proteins, amyloid-beta protein 40 and amyloid-beta protein 42, major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59). PSEN1 cleavage is more efficient with C83 than with C99 as substrate (in vitro) (PubMed:30630874). Many other minor amyloid-beta peptides, amyloid-beta 1-X peptides, are found in cerebral spinal fluid (CSF) including the amyloid-beta X-15 peptides, produced from the cleavage by alpha-secretase and all terminating at Gln-686.;Phosphorylation in the C-terminal on tyrosine, threonine and serine residues is neuron-specific (PubMed:10341243). Phosphorylation can affect APP processing, neuronal differentiation and interaction with other proteins (PubMed:10341243). Phosphorylated on Thr-743 in neuronal cells by Cdc5 kinase and Mapk10, in dividing cells by Cdc2 kinase in a cell-cycle dependent manner with maximal levels at the G2/M phase and, in vitro, by GSK-3-beta (PubMed:8131745, PubMed:11146006). The Thr-743 phosphorylated form causes a conformational change which reduces binding of Fe65 family members (PubMed:11517218). In dopaminergic (DA) neurons, phosphorylation on Thr-743 by LRKK2 promotes the production and the nuclear translocation of the APP intracellular domain (AICD) which induces DA neuron apoptosis (PubMed:28720718). Phosphorylation on Tyr-757 is required for SHC binding (PubMed:11877420). Phosphorylated in the extracellular domain by casein kinases on both soluble and membrane-bound APP. This phosphorylation is inhibited by heparin (PubMed:8999878).;Extracellular binding and reduction of copper, results in a corresponding oxidation of Cys-144 and Cys-158, and the formation of a disulfide bond. In vitro, the APP-Cu(+) complex in the presence of hydrogen peroxide results in an increased production of amyloid-beta-containing peptides.	Belongs to the APP family.	Alzheimer's disease;G alpha (i) signalling events;G alpha (q) signalling events;Advanced glycosylation endproduct receptor signaling;The NLRP3 inflammasome;Amyloid fiber formation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;Lysosome Vesicle Biogenesis;Platelet degranulation;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Formyl peptide receptors bind formyl peptides and many other ligands;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Post-translational protein phosphorylation;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	21
+NX_P05089	Arginase-1	322	34735	6.72	0	Cytoplasm;Cytoplasmic granule	Argininemia	Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.;Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed:15546957, PubMed:16709924, PubMed:19380772). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.	NA	Belongs to the arginase family.	Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.;Arginine and proline metabolism;Metabolic pathways;Amoebiasis;Urea cycle;Neutrophil degranulation	PE1	6
+NX_P05090	Apolipoprotein D	189	21276	5.06	0	Secreted;Cell membrane	NA	APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.	N-glycosylatd. N-glycan heterogeneity at Asn-65: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); at Asn-98: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), dHex1Hex6HexNAc5 (minor) and dHex1Hex7HexNAc6 (minor).	Belongs to the calycin superfamily. Lipocalin family.	Transport of fatty acids	PE1	3
+NX_P05091	Aldehyde dehydrogenase, mitochondrial	517	56381	6.63	0	Mitochondrion matrix	NA	NA	NA	Belongs to the aldehyde dehydrogenase family.	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.;Glycolysis / Gluconeogenesis;Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Lysine degradation;Arginine and proline metabolism;Histidine metabolism;Tryptophan metabolism;beta-Alanine metabolism;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Ethanol oxidation;Metabolism of serotonin	PE1	12
+NX_P05093	Steroid 17-alpha-hydroxylase/17,20 lyase	508	57371	8.72	0	Microsome membrane;Endoplasmic reticulum membrane	Adrenal hyperplasia 5	A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938). Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (PubMed:9452426, PubMed:25301938) (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938). Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis (PubMed:27339894, PubMed:25301938). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938).	Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.	Belongs to the cytochrome P450 family.	Steroid hormone biosynthesis.;Steroid biosynthesis; glucocorticoid biosynthesis.;Steroid hormone biosynthesis;Metabolic pathways;Glucocorticoid biosynthesis;Androgen biosynthesis;Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)	PE1	10
+NX_P05106	Integrin beta-3	788	87058	5.09	1	Postsynaptic cell membrane;Cell membrane;Focal adhesion;Lamellipodium membrane;Nucleoplasm;Synapse	Bleeding disorder, platelet-type 16;Glanzmann thrombasthenia	(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5.;(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.;(Microbial infection) Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus.;(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus.;(Microbial infection) Acts as a receptor for Hantaan virus.;(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9.;(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8.;(Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1.;Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity).	Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.	Belongs to the integrin beta chain family.	Phagosome;Osteoclast differentiation;Focal adhesion;ECM-receptor interaction;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;VEGFA-VEGFR2 Pathway;Signal transduction by L1;Syndecan interactions;MAP2K and MAPK activation;Integrin cell surface interactions;Platelet degranulation;ECM proteoglycans;Molecules associated with elastic fibres;Elastic fibre formation;PECAM1 interactions;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	17
+NX_P05107	Integrin beta-2	769	84782	6.66	1	Cytoplasm;Membrane raft;Cell membrane	Leukocyte adhesion deficiency 1	Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).	Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305). Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335).	Belongs to the integrin beta chain family.	Phagosome;Cell adhesion molecules (CAMs);Natural killer cell mediated cytotoxicity;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Pertussis;Legionellosis;Leishmaniasis;Malaria;Amoebiasis;Staphylococcus aureus infection;Tuberculosis;HTLV-I infection;Rheumatoid arthritis;Viral myocarditis;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Toll Like Receptor 4 (TLR4) Cascade;Integrin cell surface interactions;Cell surface interactions at the vascular wall;Neutrophil degranulation;Interleukin-4 and Interleukin-13 signaling	PE1	21
+NX_P05108	Cholesterol side-chain cleavage enzyme, mitochondrial	521	60102	8.89	0	Mitochondrion inner membrane	Adrenal insufficiency, congenital, with 46,XY sex reversal	A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:21636783). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:21636783). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:21636783).	NA	Belongs to the cytochrome P450 family.	Steroid metabolism; cholesterol metabolism.;Lipid metabolism; C21-steroid hormone metabolism.;Steroid hormone biosynthesis;Metabolic pathways;Pregnenolone biosynthesis;Endogenous sterols;Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	PE1	15
+NX_P05109	Protein S100-A8	93	10835	6.51	0	Cytoplasm;Cell membrane;Secreted;Cytosol;Cytoskeleton	NA	S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity.	NA	Belongs to the S-100 family.	RHO GTPases Activate NADPH Oxidases;Regulation of TLR by endogenous ligand;Neutrophil degranulation;Metal sequestration by antimicrobial proteins	PE1	1
+NX_P05111	Inhibin alpha chain	366	39670	8.29	0	Cytoplasmic vesicle;Secreted	NA	Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.	Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference.	Belongs to the TGF-beta family.	Glycoprotein hormones	PE1	2
+NX_P05112	Interleukin-4	153	17492	9.17	0	Secreted	Ischemic stroke	Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).	NA	Belongs to the IL-4/IL-13 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Intestinal immune network for IgA production;Leishmaniasis;Measles;Asthma;Autoimmune thyroid disease;Allograft rejection;Interleukin-4 and Interleukin-13 signaling;Interleukin-18 signaling	PE1	5
+NX_P05113	Interleukin-5	134	15238	7.81	0	Secreted	NA	Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.	NA	Belongs to the IL-5 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Intestinal immune network for IgA production;Asthma;Autoimmune thyroid disease;Allograft rejection;RAF/MAP kinase cascade;Interleukin receptor SHC signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling	PE1	5
+NX_P05114	Non-histone chromosomal protein HMG-14	100	10659	9.6	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).	Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.;HMGN1 is phosphorylated by PRKACA	Belongs to the HMGN family.	Herpes simplex infection;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER	PE1	21
+NX_P05120	Plasminogen activator inhibitor 2	415	46596	5.46	0	Cytoplasm;Extracellular space	NA	Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.	The signal sequence is not cleaved.	Belongs to the serpin family. Ov-serpin subfamily.	Amoebiasis;Dissolution of Fibrin Clot;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	18
+NX_P05121	Plasminogen activator inhibitor 1	402	45060	6.68	0	Cytosol;Secreted	Plasminogen activator inhibitor-1 deficiency	Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).	Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.	Belongs to the serpin family.	p53 signaling pathway;Complement and coagulation cascades;Chagas disease (American trypanosomiasis);SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Platelet degranulation;ECM proteoglycans;Dissolution of Fibrin Clot	PE1	7
+NX_P05129	Protein kinase C gamma type	697	78448	7.27	0	Cytoplasm;Synaptosome;Cell membrane;Dendrite;Perinuclear region	Spinocerebellar ataxia 14	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity).	Ubiquitinated.;Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4.;Autophosphorylated (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	MAPK signaling pathway;ErbB signaling pathway;Calcium signaling pathway;Phosphatidylinositol signaling system;Vascular smooth muscle contraction;Wnt signaling pathway;VEGF signaling pathway;Focal adhesion;Tight junction;Gap junction;Natural killer cell mediated cytotoxicity;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Long-term depression;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Vibrio cholerae infection;African trypanosomiasis;Amoebiasis;Pathways in cancer;Glioma;Non-small cell lung cancer;G alpha (z) signalling events;WNT5A-dependent internalization of FZD4;Calmodulin induced events;Disinhibition of SNARE formation;Trafficking of GluR2-containing AMPA receptors;Response to elevated platelet cytosolic Ca2+	PE1	19
+NX_P05141	ADP/ATP translocase 2	298	32852	9.71	6	Cytoplasm;Mitochondrion inner membrane	NA	Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.	Trimethylated by ANTKMT at Lys-52.	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Calcium signaling pathway;Parkinson's disease;Huntington's disease;HTLV-I infection;Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane;Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	PE1	X
+NX_P05154	Plasma serine protease inhibitor	406	45675	9.3	0	Mitochondrion;Extracellular space	NA	Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.	N- and O-glycosylated. N-glycosylation consists of a mixture of sialylated bi- (including sialyl-Lewis X epitopes), tri- and tetra-antennary complex-type chains; affects the maximal heparin- and thrombomodulin-enhanced rates of thrombin inhibition. O-glycosylated with core 1 or possibly core 8 glycans. Further modified with 2 sialic acid residues.;Proteolytically cleaved. Inhibition of proteases is accompanied by formation of a stable enzyme-inhibitor complex and by degradation of the serpin to lower molecular weight derivatives. Proteolytically cleaved at the N-terminus; inhibits slightly the heparin- and thrombomodulin-enhanced rates of thrombin inhibition.	Belongs to the serpin family.	Complement and coagulation cascades;Common Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation	PE1	14
+NX_P05155	Plasma protease C1 inhibitor	500	55154	6.09	0	Secreted	Hereditary angioedema	Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.	Can be proteolytically cleaved by E.coli stcE.;Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).	Belongs to the serpin family.	Complement and coagulation cascades;Pertussis;Regulation of Complement cascade;Platelet degranulation;Intrinsic Pathway of Fibrin Clot Formation	PE1	11
+NX_P05156	Complement factor I	583	65750	7.72	0	Secreted;Extracellular space	Hemolytic uremic syndrome atypical 3;Complement factor I deficiency;Macular degeneration, age-related, 13	Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins (PubMed:7360115, PubMed:17320177). Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces (PubMed:2141838, PubMed:9605165, PubMed:12055245). The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization (PubMed:28671664).	NA	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Staphylococcus aureus infection;Regulation of Complement cascade	PE1	4
+NX_P05160	Coagulation factor XIII B chain	661	75511	6.01	0	Secreted	Factor XIII subunit B deficiency	The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.	NA	NA	Complement and coagulation cascades;Common Pathway of Fibrin Clot Formation	PE1	1
+NX_P05161	Ubiquitin-like protein ISG15	165	17888	6.83	0	Cytoplasm;Secreted	Immunodeficiency 38, with basal ganglia calcification	Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade thereby inhibiting IFNA-induced JNK signaling. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A, HIV-1 and Ebola virus. Restricts HIV-1 and ebola virus via disruption of viral budding. Inhibits the ubiquitination of HIV-1 Gag and host TSG101 and disrupts their interaction, thereby preventing assembly and release of virions from infected cells. Inhibits Ebola virus budding mediated by the VP40 protein by disrupting ubiquitin ligase activity of NEDD4 and its ability to ubiquitinate VP40. ISGylates influenza A virus NS1 protein which causes a loss of function of the protein and the inhibition of virus replication. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity. The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (PubMed:29100055).	S-nitrosylation decreases its dimerization, thereby increasing the availability as well as the solubility of monomeric ISG15 for its conjugation to cellular proteins.;Induced as an inactive, precursor protein that is cleaved by specific proteases to expose the C-terminal diglycine (LRLRGG) motif. This motif is essential not only for its conjugation to substrates but also for its recognition by the relevant processing proteases.	NA	RIG-I-like receptor signaling pathway;ISG15 antiviral mechanism;Interferon alpha/beta signaling;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;Termination of translesion DNA synthesis;NS1 Mediated Effects on Host Pathways	PE1	1
+NX_P05162	Galectin-2	132	14644	5.93	0	Nucleoplasm;Mitochondrion	NA	This protein binds beta-galactoside. Its physiological function is not yet known.	NA	NA	NA	PE1	22
+NX_P05164	Myeloperoxidase	745	83869	9.19	0	Cytoplasmic vesicle;Nucleoplasm;Lysosome	Myeloperoxidase deficiency	Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.	NA	Belongs to the peroxidase family. XPO subfamily.	Phagosome;Neutrophil degranulation;Events associated with phagocytolytic activity of PMN cells	PE1	17
+NX_P05165	Propionyl-CoA carboxylase alpha chain, mitochondrial	728	80059	7.24	0	Mitochondrion matrix;Mitochondrion	Propionic acidemia type I	NA	Acetylated.	NA	Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.;Valine, leucine and isoleucine degradation;Glyoxylate and dicarboxylate metabolism;Propanoate metabolism;Metabolic pathways;Propionyl-CoA catabolism;Biotin transport and metabolism;Defective HLCS causes multiple carboxylase deficiency	PE1	13
+NX_P05166	Propionyl-CoA carboxylase beta chain, mitochondrial	539	58216	7.56	0	Mitochondrion matrix	Propionic acidemia type II	NA	NA	Belongs to the AccD/PCCB family.	Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.;Valine, leucine and isoleucine degradation;Glyoxylate and dicarboxylate metabolism;Propanoate metabolism;Metabolic pathways;Propionyl-CoA catabolism;Biotin transport and metabolism;Defective HLCS causes multiple carboxylase deficiency	PE1	3
+NX_P05177	Cytochrome P450 1A2	516	58407	9.18	0	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable).	NA	Belongs to the cytochrome P450 family.	Cofactor metabolism; retinol metabolism.;Lipid metabolism; arachidonate metabolism.;Steroid metabolism; cholesterol metabolism.;Caffeine metabolism;Tryptophan metabolism;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Methylation;Aflatoxin activation and detoxification;Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET);Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE);Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2;Biosynthesis of maresin-like SPMs;Biosynthesis of protectins	PE1	15
+NX_P05181	Cytochrome P450 2E1	493	56849	8.28	0	Microsome membrane;Mitochondrion inner membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; fatty acid metabolism.;Arachidonic acid metabolism;Linoleic acid metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Xenobiotics;CYP2E1 reactions;Biosynthesis of maresin-like SPMs	PE1	10
+NX_P05186	Alkaline phosphatase, tissue-nonspecific isozyme	524	57305	6.19	0	Cytosol;Cell membrane	Hypophosphatasia infantile type;Hypophosphatasia childhood type;Hypophosphatasia	This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi).	N-glycosylated.	Belongs to the alkaline phosphatase family.	Folate biosynthesis;Metabolic pathways;Post-translational modification: synthesis of GPI-anchored proteins	PE1	1
+NX_P05187	Alkaline phosphatase, placental type	535	57954	5.86	1	Cell membrane	NA	NA	NA	Belongs to the alkaline phosphatase family.	Folate biosynthesis;Metabolic pathways;Intra-Golgi traffic	PE1	2
+NX_P05198	Eukaryotic translation initiation factor 2 subunit 1	315	36112	5.02	0	Cytosol;Stress granule	NA	Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.	Substrate for at least 4 kinases: EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation (PubMed:15207627, PubMed:18032499). Phosphorylated; phosphorylation on Ser-52 by the EIF2AK4/GCN2 protein kinase occurs in response to amino acid starvation and UV irradiation (By similarity).	Belongs to the eIF-2-alpha family.	RNA transport;Protein processing in endoplasmic reticulum;Hepatitis C;Measles;Influenza A;Herpes simplex infection;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP;ABC-family proteins mediated transport;PERK regulates gene expression	PE1	14
+NX_P05204	Non-histone chromosomal protein HMG-17	90	9393	10	0	Cytoplasm;Nucleus	NA	Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).	Phosphorylation favors cytoplasmic localization.	Belongs to the HMGN family.	NA	PE1	1
+NX_P05230	Fibroblast growth factor 1	155	17460	6.52	0	Cytoplasm;Cell cortex;Secreted;Nucleoplasm;Cytosol;Nucleus	NA	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).	In the nucleus, phosphorylated by PKC/PRKCD.	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;FGFR2b ligand binding and activation;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR1;Signaling by activated point mutants of FGFR3;FGFR4 ligand binding and activation;FGFR3c ligand binding and activation;FGFR1c ligand binding and activation;FGFR2c ligand binding and activation;FGFR3 mutant receptor activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;Phospholipase C-mediated cascade, FGFR4;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;FGFR1b ligand binding and activation;FGFR3b ligand binding and activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR2 IIIa TM	PE1	5
+NX_P05231	Interleukin-6	212	23718	6.17	0	Cytoplasmic vesicle;Secreted	Rheumatoid arthritis systemic juvenile	Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.	N- and O-glycosylated.	Belongs to the IL-6 superfamily.	Cytokine-cytokine receptor interaction;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Hematopoietic cell lineage;Intestinal immune network for IgA production;Prion diseases;Salmonella infection;Pertussis;Legionellosis;Chagas disease (American trypanosomiasis);African trypanosomiasis;Malaria;Amoebiasis;Tuberculosis;Measles;Influenza A;HTLV-I infection;Herpes simplex infection;Senescence-Associated Secretory Phenotype (SASP);Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MAPK3 (ERK1) activation;Interleukin-6 signaling;MAPK1 (ERK2) activation;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Post-translational protein phosphorylation	PE1	7
+NX_P05305	Endothelin-1	212	24425	9.52	0	Golgi apparatus;Nucleoplasm;Secreted;Nucleolus	Auriculocondylar syndrome 3;Question mark ears, isolated	Endothelins are endothelium-derived vasoconstrictor peptides.	NA	Belongs to the endothelin/sarafotoxin family.	Melanogenesis;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	6
+NX_P05362	Intercellular adhesion molecule 1	532	57825	8.31	1	Membrane;Cytosol;Cell membrane	NA	(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.;(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.;ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.;(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.	Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.	Belongs to the immunoglobulin superfamily. ICAM family.	Cell adhesion molecules (CAMs);Natural killer cell mediated cytotoxicity;Leukocyte transendothelial migration;African trypanosomiasis;Malaria;Staphylococcus aureus infection;Influenza A;HTLV-I infection;Rheumatoid arthritis;Viral myocarditis;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Interferon gamma signaling;Integrin cell surface interactions;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling	PE1	19
+NX_P05386	60S acidic ribosomal protein P1	114	11514	4.26	0	Endoplasmic reticulum;Cytosol;Cytoplasm	NA	Plays an important role in the elongation step of protein synthesis.	NA	Belongs to the eukaryotic ribosomal protein P1/P2 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	15
+NX_P05387	60S acidic ribosomal protein P2	115	11665	4.42	0	Cytoplasm;Mitochondrion	NA	Plays an important role in the elongation step of protein synthesis.	RPLP2 is phosphorylated by MAPK3	Belongs to the eukaryotic ribosomal protein P1/P2 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	11
+NX_P05388	60S acidic ribosomal protein P0	317	34274	5.72	0	Cytoplasm;Nucleus	NA	Ribosomal protein P0 is the functional equivalent of E.coli protein L10.	RPLP0 is phosphorylated by MAPK3	Belongs to the universal ribosomal protein uL10 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	12
+NX_P05408	Neuroendocrine protein 7B2	212	23730	5.62	0	Secreted	NA	Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.	Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.;Sulfated on tyrosine residues.	Belongs to the 7B2 family.	NA	PE1	15
+NX_P05412	Transcription factor AP-1	331	35676	8.9	0	Nucleoplasm;Nucleus	NA	Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).	Acetylated at Lys-271 by EP300.;Ubiquitinated by the SCF(FBXW7), leading to its degradation (PubMed:14739463, PubMed:27458189). Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (PubMed:14739463).;Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.;JUN is phosphorylated by IKBKE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);JUN is phosphorylated by MAPK3;JUN is phosphorylated by GSK3B (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the bZIP family. Jun subfamily.	MAPK signaling pathway;ErbB signaling pathway;Wnt signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Neurotrophin signaling pathway;GnRH signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Salmonella infection;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);Influenza A;HTLV-I infection;Herpes simplex infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Rheumatoid arthritis;MAPK6/MAPK4 signaling;Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;Senescence-Associated Secretory Phenotype (SASP);Pre-NOTCH Transcription and Translation;Activation of the AP-1 family of transcription factors;Activation of anterior HOX genes in hindbrain development during early embryogenesis;TP53 Regulates Transcription of DNA Repair Genes;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Regulation of PTEN gene transcription;Estrogen-dependent gene expression	PE1	1
+NX_P05413	Fatty acid-binding protein, heart	133	14858	6.29	0	Golgi apparatus;Cytoplasm;Focal adhesion;Cell membrane	NA	FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	PPAR signaling pathway;Triglyceride catabolism	PE1	1
+NX_P05423	DNA-directed RNA polymerase III subunit RPC4	398	44396	6.51	0	Nucleoplasm;Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).	NA	Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	8
+NX_P05451	Lithostathine-1-alpha	166	18731	5.65	0	Secreted	NA	Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.	The composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the crystallographic structure, the attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than N-acetylgalactosamine.	NA	NA	PE1	2
+NX_P05452	Tetranectin	202	22537	5.52	0	Secreted	NA	Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis.	NA	NA	Platelet degranulation	PE1	3
+NX_P05455	Lupus La protein	408	46837	6.68	0	Nucleoplasm;Nucleus	NA	Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).	The N-terminus is blocked.;Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.	NA	Systemic lupus erythematosus;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation	PE1	2
+NX_P05496	ATP synthase F(0) complex subunit C1, mitochondrial	136	14277	9.81	2	Mitochondrion membrane;Mitochondrion	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.	Trimethylated by ATPSCKMT at Lys-104. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.	Belongs to the ATPase C chain family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Mitochondrial protein import;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	17
+NX_P05538	HLA class II histocompatibility antigen, DQ beta 2 chain	268	30387	6.32	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;Lysosome membrane;trans-Golgi network membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	NA	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P05543	Thyroxine-binding globulin	415	46325	5.87	0	Secreted	NA	Major thyroid hormone transport protein in serum.	NA	Belongs to the serpin family.	NA	PE1	X
+NX_P05546	Heparin cofactor 2	499	57071	6.41	0	Cytoplasmic vesicle	Thrombophilia due to heparin cofactor 2 deficiency	Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.;Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.	Phosphorylated by FAM20C in the extracellular medium.	Belongs to the serpin family.	Complement and coagulation cascades;Common Pathway of Fibrin Clot Formation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Intrinsic Pathway of Fibrin Clot Formation;Post-translational protein phosphorylation	PE1	22
+NX_P05549	Transcription factor AP-2-alpha	437	48062	8.1	0	Nucleoplasm;Nucleus	Branchiooculofacial syndrome	Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.	Sumoylated on Lys-10; which inhibits transcriptional activity.	Belongs to the AP-2 family.	SUMOylation of transcription factors;Activation of the TFAP2 (AP-2) family of transcription factors;TFAP2 (AP-2) family regulates transcription of other transcription factors;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;TFAP2 (AP-2) family regulates transcription of cell cycle factors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	PE1	6
+NX_P05556	Integrin beta-1	798	88415	5.27	1	Cleavage furrow;Cell membrane;Recycling endosome;Cell junction;Focal adhesion;Cell surface;Endoplasmic reticulum;Lamellipodium;Melanosome;Invadopodium membrane;Ruffle;Ruffle membrane;Sarcolemma	NA	(Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5.;(Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.;(Microbial infection) Acts as a receptor for Mammalian reovirus.;Displaces isoform 1 in striated muscles.;(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus.;(Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4.;(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19.;(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.;Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands.;Interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).	The cysteine residues are involved in intrachain disulfide bonds.	Belongs to the integrin beta chain family.	Phagosome;Axon guidance;Focal adhesion;ECM-receptor interaction;Cell adhesion molecules (CAMs);Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;Pertussis;Leishmaniasis;Toxoplasmosis;Pathways in cancer;Small cell lung cancer;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;RHO GTPases Activate Formins;Signal transduction by L1;Syndecan interactions;Integrin cell surface interactions;Cell surface interactions at the vascular wall;ECM proteoglycans;Molecules associated with elastic fibres;Basigin interactions;Other semaphorin interactions;CHL1 interactions;Elastic fibre formation;Platelet Adhesion to exposed collagen;Laminin interactions;Fibronectin matrix formation;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;MET activates PTK2 signaling;MET interacts with TNS proteins;Interleukin-4 and Interleukin-13 signaling	PE1	10
+NX_P05771	Protein kinase C beta type	671	76869	6.57	0	Cytoplasm;Membrane;Nucleoplasm;Cytosol;Nucleus	NA	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525).	Phosphorylation on Thr-500 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Autophosphorylation on other sites i.e. In the N-terminal and hinge regions have no effect on enzyme activity. Phosphorylation at Tyr-662 by SYK induces binding with GRB2 and contributes to the activation of MAPK/ERK signaling cascade (By similarity).	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	MAPK signaling pathway;ErbB signaling pathway;Calcium signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;Vascular smooth muscle contraction;Wnt signaling pathway;VEGF signaling pathway;Focal adhesion;Tight junction;Gap junction;Natural killer cell mediated cytotoxicity;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Long-term depression;GnRH signaling pathway;Melanogenesis;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Vibrio cholerae infection;Leishmaniasis;African trypanosomiasis;Amoebiasis;Influenza A;Pathways in cancer;Glioma;Non-small cell lung cancer;Activation of NF-kappaB in B cells;G alpha (z) signalling events;WNT5A-dependent internalization of FZD4;Depolymerisation of the Nuclear Lamina;VEGFR2 mediated cell proliferation;RHO GTPases Activate NADPH Oxidases;Disinhibition of SNARE formation;Trafficking of GluR2-containing AMPA receptors;Response to elevated platelet cytosolic Ca2+;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	PE1	16
+NX_P05783	Keratin, type I cytoskeletal 18	430	48058	5.34	0	Cytoplasm;Cytosol;Perinuclear region;Nucleolus	Cirrhosis	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.	O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.;Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.;Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.;KRT18 is phosphorylated by PRKCE (Phosphoserine:PTM-0253);KRT18 is phosphorylated by CDK1	Belongs to the intermediate filament family.	Pathogenic Escherichia coli infection;Formation of the cornified envelope;Keratinization	PE1	12
+NX_P05787	Keratin, type II cytoskeletal 8	483	53704	5.52	0	Cytoplasm;Nucleoplasm;Nucleus matrix;Cytoskeleton	Cirrhosis	Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.	O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.;O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.;Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.;KRT8 is phosphorylated by PRKCE (Phosphoserine:PTM-0253)	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_P05813	Beta-crystallin A3	215	25150	5.82	0	NA	Cataract 10, multiple types	Crystallins are the dominant structural components of the vertebrate eye lens.	Specific cleavages in the N-terminal arm occur during lens maturation and give rise to several truncated forms. Cleavages do not seem to have adverse effects on solubility.;S-methylation and glutathionylation occur in normal young lenses and do not seem to be detrimental.	Belongs to the beta/gamma-crystallin family.	NA	PE1	17
+NX_P05814	Beta-casein	226	25382	5.52	0	Secreted	NA	Important role in determination of the surface properties of the casein micelles.	Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25.	Belongs to the beta-casein family.	Nuclear signaling by ERBB4	PE1	4
+NX_P05937	Calbindin	261	30025	4.7	0	Cytoplasmic vesicle	NA	Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	NA	Belongs to the calbindin family.	Endocrine and other factor-regulated calcium reabsorption;Amyloid fiber formation	PE1	8
+NX_P05976	Myosin light chain 1/3, skeletal muscle isoform	194	21145	4.97	0	NA	Myopathy, congenital, with fast-twitch type II fiber atrophy	Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function.	Acetylated at position 2.	NA	Striated Muscle Contraction	PE1	2
+NX_P05981	Serine protease hepsin	417	45011	7.8	1	Apical cell membrane;Cell membrane	NA	Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).	NA	Belongs to the peptidase S1 family.	Signaling by MST1;MET Receptor Activation	PE1	19
+NX_P05997	Collagen alpha-2(V) chain	1499	144910	6.07	0	Extracellular matrix	Ehlers-Danlos syndrome, classic type, 2	Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity).	Prolines at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Probably 3-hydroxylated on Pro-919 and Pro-1156 by LEPREL1.	Belongs to the fibrillar collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Syndecan interactions;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Non-integrin membrane-ECM interactions;Extracellular matrix organization;MET activates PTK2 signaling;Collagen chain trimerization	PE1	2
+NX_P06028	Glycophorin-B	91	9782	9.43	1	Cell membrane	NA	This protein is a minor sialoglycoprotein in erythrocyte membranes.	The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.	Belongs to the glycophorin-A family.	Malaria;Cell surface interactions at the vascular wall	PE1	4
+NX_P06126	T-cell surface glycoprotein CD1a	327	37077	6.3	1	Endosome membrane;Membrane raft;Cell membrane	NA	Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.	NA	NA	Hematopoietic cell lineage;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	1
+NX_P06127	T-cell surface glycoprotein CD5	495	54578	8.59	1	Cell membrane	NA	May act as a receptor in regulating T-cell proliferation.	Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.;CD5 is phosphorylated by ITK	NA	Hematopoietic cell lineage	PE1	11
+NX_P06132	Uroporphyrinogen decarboxylase	367	40787	5.77	0	Nucleoplasm;Cytoplasm;Cytosol	Familial porphyria cutanea tarda;Hepatoerythropoietic porphyria	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.	NA	Belongs to the uroporphyrinogen decarboxylase family.	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.;Porphyrin and chlorophyll metabolism;Metabolic pathways;Heme biosynthesis	PE1	1
+NX_P06133	UDP-glucuronosyltransferase 2B4	528	60513	8.7	1	Microsome membrane;Endoplasmic reticulum membrane	NA	UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Bile secretion;Glucuronidation	PE1	4
+NX_P06213	Insulin receptor	1382	156333	5.83	1	Cytoplasmic vesicle;Lysosome;Late endosome;Cell membrane	Familial hyperinsulinemic hypoglycemia 5;Leprechaunism;Rabson-Mendenhall syndrome;Diabetes mellitus, non-insulin-dependent;Insulin-resistant diabetes mellitus with acanthosis nigricans type A	Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII).;Has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity).	After being transported from the endoplasmic reticulum to the Golgi apparatus, the single glycosylated precursor is further glycosylated and then cleaved, followed by its transport to the plasma membrane.;Autophosphorylated on tyrosine residues in response to insulin. Phosphorylation of Tyr-999 is required for binding to IRS1, SHC1 and STAT5B. Dephosphorylated by PTPRE at Tyr-999, Tyr-1185, Tyr-1189 and Tyr-1190. Dephosphorylated by PTPRF and PTPN1. Dephosphorylated by PTPN2; down-regulates insulin-induced signaling.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	Adherens junction;Insulin signaling pathway;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Insulin receptor recycling;IRS activation;Signal attenuation;Insulin receptor signalling cascade;Signaling by Insulin receptor;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	19
+NX_P06239	Tyrosine-protein kinase Lck	509	58001	5.23	0	Golgi apparatus;Cytoplasm;Cell membrane	Immunodeficiency 22	Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501).	Palmitoylation regulates subcellular location.;Myristoylation is required prior to palmitoylation.;Autophosphorylated on Tyr-394, increasing enzymatic activity, this site is dephosphorylated by PTN22. Phosphorylated on Tyr-505 by CSK, decreasing activity. Dephosphorylated by PTPRC/CD45. Dephosphorylation at Tyr-394 by PTPN2 negatively regulates T-cell receptor signaling.;LCK is phosphorylated by CDK1	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.	Osteoclast differentiation;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;HTLV-I infection;Primary immunodeficiency;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;GPVI-mediated activation cascade;DAP12 signaling;CD28 dependent PI3K/Akt signaling;Signaling by SCF-KIT;Regulation of KIT signaling;CD28 co-stimulation;CD28 dependent Vav1 pathway;Nef Mediated CD4 Down-regulation;Nef and signal transduction;PECAM1 interactions;CTLA4 inhibitory signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-2 signaling	PE1	1
+NX_P06241	Tyrosine-protein kinase Fyn	537	60762	6.23	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.	Palmitoylation at Cys-3 and Cys-6 regulates subcellular location.;Autophosphorylated at Tyr-420 (By similarity). Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an inactive state (PubMed:1699196). PTPRC/CD45 dephosphorylates Tyr-531 leading to activation (PubMed:1533589). Ultraviolet B (UVB) strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to the nucleus (PubMed:15537652). Dephosphorylation at Tyr-420 by PTPN2 negatively regulates T-cell receptor signaling (PubMed:22080863). Phosphorylated at tyrosine residues, which can be enhanced by NTN1 (By similarity).;FYN is phosphorylated by PRKCH;FYN is phosphorylated by CSK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.	Axon guidance;Osteoclast differentiation;Focal adhesion;Adherens junction;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Cholinergic synapse;Prion diseases;Pathogenic Escherichia coli infection;Measles;Viral myocarditis;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Role of LAT2/NTAL/LAB on calcium mobilization;GPVI-mediated activation cascade;EPH-Ephrin signaling;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;DAP12 signaling;VEGFA-VEGFR2 Pathway;EPHA-mediated growth cone collapse;CD28 dependent PI3K/Akt signaling;Signaling by ERBB2;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Cell surface interactions at the vascular wall;Signaling by SCF-KIT;Regulation of KIT signaling;CD28 co-stimulation;CD28 dependent Vav1 pathway;Dectin-2 family;Sema3A PAK dependent Axon repulsion;CRMPs in Sema3A signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CD209 (DC-SIGN) signaling;Nephrin family interactions;FCGR activation;Nef and signal transduction;PECAM1 interactions;NCAM signaling for neurite out-growth;CTLA4 inhibitory signaling;DCC mediated attractive signaling;Platelet Adhesion to exposed collagen;Regulation of signaling by CBL;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Reelin signalling pathway;NTRK2 activates RAC1;Activated NTRK2 signals through FYN;FLT3 Signaling	PE1	6
+NX_P06276	Cholinesterase	602	68418	7.12	0	Secreted	Butyrylcholinesterase deficiency	Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.	N-glycosylated. No other PTM detected (PubMed:20946535). The major N-glycan structures are of the complex diantennary type with 1 and 2 N-acetylneuraminic acid molecules (Neu5Ac) making up approximately 33% and 47% of the total N-glycans, respectively. Only low amounts of fucosylated diantennary N-glycans are detected (approximately 2%). Triantennary N-glycans with or without fucose amount to approximately 13%, whereas 5% of the total N-glycans are of the oligomannosidic or hybrid type.	Belongs to the type-B carboxylesterase/lipase family.	Synthesis of PC;Synthesis, secretion, and deacylation of Ghrelin;Neurotransmitter clearance	PE1	3
+NX_P06280	Alpha-galactosidase A	429	48767	5.35	0	Lysosome	Fabry disease	NA	NA	Belongs to the glycosyl hydrolase 27 family.	Galactose metabolism;Glycerolipid metabolism;Sphingolipid metabolism;Glycosphingolipid biosynthesis - globo series;Lysosome;Glycosphingolipid metabolism;Neutrophil degranulation	PE1	X
+NX_P06307	Cholecystokinin	115	12669	9.18	0	Secreted	NA	This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.	The precursor is cleaved by proteases to produce a number of active cholecystokinins.	Belongs to the gastrin/cholecystokinin family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	3
+NX_P06310	Immunoglobulin kappa variable 2-30	120	13185	8.71	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P06312	Immunoglobulin kappa variable 4-1	121	13380	5.09	0	Secreted;Cell membrane	NA	V segment of the variable domain of immunoglobulins light chain that participates to the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P06315	Immunoglobulin kappa variable 5-2	115	12728	4.21	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	2
+NX_P06331	Immunoglobulin heavy variable 4-34	123	13815	9.39	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P06340	HLA class II histocompatibility antigen, DO alpha chain	250	27599	5.57	1	Lysosome membrane;Endosome membrane	NA	Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.	NA	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation	PE1	6
+NX_P06396	Gelsolin	782	85698	5.9	0	Secreted;Cytoskeleton	Amyloidosis 5	Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.	Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.;GSN is phosphorylated by TNIK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the villin/gelsolin family.	Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Amyloid fiber formation;Caspase-mediated cleavage of cytoskeletal proteins;Neutrophil degranulation	PE1	9
+NX_P06400	Retinoblastoma-associated protein	928	106159	8.13	0	Nucleoplasm;Nucleus	Osteogenic sarcoma;Bladder cancer;Childhood cancer retinoblastoma	(Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.;Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity).	Acetylation at Lys-873 and Lys-874 regulates subcellular localization, at least during keratinocytes differentiation.;N-terminus is methylated by METTL11A/NTM1 (By similarity). Monomethylation at Lys-810 by SMYD2 enhances phosphorylation at Ser-807 and Ser-811, and promotes cell cycle progression. Monomethylation at Lys-860 by SMYD2 promotes interaction with L3MBTL1.;Phosphorylated by CDK6 and CDK4, and subsequently by CDK2 at Ser-567 in G1, thereby releasing E2F1 which is then able to activate cell growth. Dephosphorylated at the late M phase. SV40 large T antigen, HPV E7 and adenovirus E1A bind to the underphosphorylated, active form of pRb. Phosphorylation at Thr-821 and Thr-826 promotes interaction between the C-terminal domain C and the Pocket domain, and thereby inhibits interactions with heterodimeric E2F/DP transcription factor complexes. Dephosphorylated at Ser-795 by calcineruin upon calcium stimulation. CDK3/cyclin-C-mediated phosphorylation at Ser-807 and Ser-811 is required for G0-G1 transition. Phosphorylated by CDK1 and CDK2 upon TGFB1-mediated apoptosis (By similarity).;RB1 is phosphorylated by CDK9	Belongs to the retinoblastoma protein (RB) family.	Cell cycle;HTLV-I infection;Pathways in cancer;Pancreatic cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Formation of Senescence-Associated Heterochromatin Foci (SAHF);Condensation of Prophase Chromosomes;Cyclin E associated events during G1/S transition;Oncogene Induced Senescence;Cyclin A:Cdk2-associated events at S phase entry;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;Cyclin D associated events in G1;RUNX2 regulates osteoblast differentiation	PE1	13
+NX_P06401	Progesterone receptor	933	98981	6.09	0	Mitochondrion outer membrane;Cytoplasm;Nucleus	NA	Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.;Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.;Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.;The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.	Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.;Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.;Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294.;Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.	Belongs to the nuclear hormone receptor family. NR3 subfamily.	Oocyte meiosis;Progesterone-mediated oocyte maturation;Nuclear signaling by ERBB4;Nuclear Receptor transcription pathway;HSP90 chaperone cycle for steroid hormone receptors (SHR);Estrogen-dependent gene expression;SUMOylation of intracellular receptors	PE1	11
+NX_P06454	Prothymosin alpha	111	12203	3.69	0	Nucleoplasm;Cytosol;Nucleus	NA	Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.	Covalently linked to a small RNA of about 20 nucleotides.	Belongs to the pro/parathymosin family.	NA	PE1	2
+NX_P06493	Cyclin-dependent kinase 1	297	34095	8.38	0	Cytoplasm;Mitochondrion;Nucleoplasm;Centrosome;Cytosol;Spindle;Nucleus	NA	(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.;Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene ARNTL/BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018).	Polyubiquitinated upon genotoxic stress.;Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. By the end of G2, PKMYT1 and WEE1 are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and CDC25B at Thr-14 and Tyr-15, leads to CDK1 activation at the G2-M transition. Phosphorylation at Tyr-15 by WEE2 during oogenesis is required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, leading to prevent meiotic reentry. Phosphorylation by WEE2 is also required for metaphase II exit during egg activation to ensure exit from meiosis in oocytes and promote pronuclear formation. Phosphorylated at Tyr-4 by PKR/EIF2AK2 upon genotoxic stress. This phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest. In response to UV irradiation, phosphorylation at Tyr-15 by PRKCD activates the G2/M DNA damage checkpoint.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Cell cycle;Oocyte meiosis;p53 signaling pathway;Gap junction;Progesterone-mediated oocyte maturation;Herpes simplex infection;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;MAPK6/MAPK4 signaling;Nuclear Pore Complex (NPC) Disassembly;Activation of NIMA Kinases NEK9, NEK6, NEK7;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Resolution of Sister Chromatid Cohesion;Condensation of Prophase Chromosomes;G1/S-Specific Transcription;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;MASTL Facilitates Mitotic Progression;APC/C:Cdc20 mediated degradation of Cyclin B;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of the APC/C;E2F-enabled inhibition of pre-replication complex formation;Phosphorylation of Emi1;Recruitment of NuMA to mitotic centrosomes;MAPK3 (ERK1) activation;Golgi Cisternae Pericentriolar Stack Reorganization;Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes;Condensation of Prometaphase Chromosomes;Depolymerisation of the Nuclear Lamina;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Regulation of TP53 Degradation;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Ovarian tumor domain proteases;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;Transcriptional regulation by RUNX2;Mitotic Prophase	PE1	10
+NX_P06576	ATP synthase subunit beta, mitochondrial	529	56560	5.26	0	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.	NA	Belongs to the ATPase alpha/beta chains family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Mitochondrial protein import;Formation of ATP by chemiosmotic coupling;Transcriptional activation of mitochondrial biogenesis;Cristae formation	PE1	12
+NX_P06681	Complement C2	752	83268	7.23	0	Secreted	Macular degeneration, age-related, 14;Complement component 2 deficiency	Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.	NA	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Pertussis;Staphylococcus aureus infection;Systemic lupus erythematosus;Regulation of Complement cascade;Initial triggering of complement;Activation of C3 and C5	PE1	6
+NX_P06702	Protein S100-A9	114	13242	5.71	0	Cytoplasm;Cell membrane;Cell junction;Secreted;Nucleoplasm;Cytosol;Cytoskeleton	NA	S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. Has transnitrosylase activity; in oxidatively-modified low-densitity lipoprotein (LDL(ox))-induced S-nitrosylation of GAPDH on 'Cys-247' proposed to transfer the NO moiety from NOS2/iNOS to GAPDH via its own S-nitrosylated Cys-3. The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif.	Phosphorylated. Phosphorylation inhibits activation of tubulin polymerization.;S-nitrosylation of Cys-3 is implicated in LDL(ox)-induced S-nitrosylation of GAPDH at 'Cys-247' through a transnitrosylase mechanism involving a iNOS-S100A8/9 complex (PubMed:25417112).	Belongs to the S-100 family.	RHO GTPases Activate NADPH Oxidases;Regulation of TLR by endogenous ligand;Neutrophil degranulation;Metal sequestration by antimicrobial proteins	PE1	1
+NX_P06703	Protein S100-A6	90	10180	5.32	0	Cytoplasm;Cytosol;Nucleus envelope;Cell membrane	NA	May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.	The N-terminus is blocked.	Belongs to the S-100 family.	NA	PE1	1
+NX_P06727	Apolipoprotein A-IV	396	45399	5.28	0	Cytoplasmic vesicle;Secreted	NA	May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.	Phosphorylation sites are present in the extracellular medium.	Belongs to the apolipoprotein A1/A4/E family.	Retinoid metabolism and transport;Amyloid fiber formation;Assembly of active LPL and LIPC lipase complexes;Chylomicron remodeling;Chylomicron assembly	PE1	11
+NX_P06729	T-cell surface antigen CD2	351	39448	9.66	1	Cell membrane	NA	CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.	NA	NA	Cell adhesion molecules (CAMs);Hematopoietic cell lineage;Cell surface interactions at the vascular wall	PE1	1
+NX_P06730	Eukaryotic translation initiation factor 4E	217	25097	5.79	0	Cytoplasm;Cytosol;P-body	Autism 19	Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.	Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.	Belongs to the eukaryotic initiation factor 4E family.	RNA transport;mTOR signaling pathway;Insulin signaling pathway;ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Deadenylation of mRNA;mTORC1-mediated signalling;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	PE1	4
+NX_P06731	Carcinoembryonic antigen-related cell adhesion molecule 5	702	76795	5.59	0	Cell surface;Apical cell membrane;Cell membrane	NA	(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.;Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).	Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall;Post-translational modification: synthesis of GPI-anchored proteins	PE1	19
+NX_P06732	Creatine kinase M-type	381	43101	6.77	0	Cytoplasm	NA	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. Creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.	NA	Belongs to the ATP:guanido phosphotransferase family.	Arginine and proline metabolism;Metabolic pathways;Creatine metabolism	PE1	19
+NX_P06733	Alpha-enolase	434	47169	7.01	0	Cytoplasm;M line;Nucleus;Cell membrane	NA	Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.;MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.	ISGylated.;ENO1 is phosphorylated by MAPK3	Belongs to the enolase family.	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.;Glycolysis / Gluconeogenesis;Metabolic pathways;RNA degradation;Glycolysis;Gluconeogenesis	PE1	1
+NX_P06734	Low affinity immunoglobulin epsilon Fc receptor	321	36469	5.38	1	Secreted;Cell membrane	NA	Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).	The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.;N- and O-glycosylated.	NA	Hematopoietic cell lineage;NOTCH2 intracellular domain regulates transcription;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling	PE1	19
+NX_P06737	Glycogen phosphorylase, liver form	847	97149	6.71	0	Cytosol;Cell membrane	Glycogen storage disease 6	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.	Belongs to the glycogen phosphorylase family.	Starch and sucrose metabolism;Insulin signaling pathway;Glycogen breakdown (glycogenolysis);Neutrophil degranulation	PE1	14
+NX_P06744	Glucose-6-phosphate isomerase	558	63147	8.42	0	Cytoplasm;Cell membrane;Secreted;Nucleoplasm;Cytosol	Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency	In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:3352745, PubMed:11004567). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:3352745, PubMed:11004567).	Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.;ISGylated.	Belongs to the GPI family.	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Glycolysis;TP53 Regulates Metabolic Genes;Gluconeogenesis;Neutrophil degranulation	PE1	19
+NX_P06746	DNA polymerase beta	335	38178	9.01	0	Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.	Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1. Monoubiquitinated protein is then the target of STUB1/CHIP, which catalyzes polyubiquitination from monoubiquitin, leading to degradation by the proteasome. USP47 mediates the deubiquitination of monoubiquitinated protein, preventing polyubiquitination by STUB1/CHIP and its subsequent degradation.;Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.	Belongs to the DNA polymerase type-X family.	Base excision repair;HTLV-I infection;POLB-Dependent Long Patch Base Excision Repair;Resolution of AP sites via the multiple-nucleotide patch replacement pathway;Resolution of AP sites via the single-nucleotide replacement pathway;APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway;PCNA-Dependent Long Patch Base Excision Repair;Abasic sugar-phosphate removal via the single-nucleotide replacement pathway;Ub-specific processing proteases	PE1	8
+NX_P06748	Nucleophosmin	294	32575	4.64	0	Nucleoplasm;Nucleus;Centrosome;Nucleolus	NA	Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).	ADP-ribosylated.;Acetylated at C-terminal lysine residues, thereby increasing affinity to histones.;Sumoylated by ARF.;Phosphorylated at Ser-4 by PLK1 and PLK2. Phosphorylation at Ser-4 by PLK2 in S phase is required for centriole duplication and is sufficient to trigger centriole replication. Phosphorylation at Ser-4 by PLK1 takes place during mitosis. Phosphorylated by CDK2 at Ser-125 and Thr-199. Phosphorylation at Thr-199 may trigger initiation of centrosome duplication. Phosphorylated by CDK1 at Thr-199, Thr-219, Thr-234 and Thr-237 during cell mitosis. When these four sites are phosphorated, RNA-binding activity seem to be abolished. May be phosphorylated at Ser-70 by NEK2. The Thr-199 phosphorylated form has higher affinity for ROCK2. CDK6 triggers Thr-199 phosphorylation when complexed to Kaposi's sarcoma herpesvirus (KSHV) V-cyclin, leading to viral reactivation by reducing viral LANA levels.;Ubiquitinated. Ubiquitination leads to proteasomal degradation. Deubiquitinated by USP36 (PubMed:19208757).;NPM1 is phosphorylated by AURKA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the nucleoplasmin family.	Nuclear import of Rev protein;Deposition of new CENPA-containing nucleosomes at the centromere;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation;SUMOylation of transcription cofactors	PE1	5
+NX_P06753	Tropomyosin alpha-3 chain	285	32950	4.68	0	Cytoplasm;Cytoskeleton	Cap myopathy 1;Nemaline myopathy 1;Myopathy, congenital, with fiber-type disproportion	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.	NA	Belongs to the tropomyosin family.	Cardiac muscle contraction;Pathways in cancer;Thyroid cancer;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Striated Muscle Contraction;Smooth Muscle Contraction	PE1	1
+NX_P06756	Integrin alpha-V	1048	116038	5.45	1	Cytosol;Focal adhesion;Cell membrane	NA	(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1.;(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8.;(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1.;(Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1.;(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C.;(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus.;(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.;The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447).	NA	Belongs to the integrin alpha chain family.	Phagosome;Focal adhesion;ECM-receptor interaction;Cell adhesion molecules (CAMs);Regulation of actin cytoskeleton;Pathways in cancer;Small cell lung cancer;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;VEGFA-VEGFR2 Pathway;Signal transduction by L1;Syndecan interactions;Integrin cell surface interactions;ECM proteoglycans;Molecules associated with elastic fibres;Elastic fibre formation;PECAM1 interactions;Cross-presentation of particulate exogenous antigens (phagosomes);Laminin interactions;Neutrophil degranulation	PE1	2
+NX_P06850	Corticoliberin	196	21422	10	0	Secreted	NA	Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).	NA	Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	Long-term depression;G alpha (s) signalling events;Class B/2 (Secretin family receptors);MECP2 regulates transcription of neuronal ligands	PE1	8
+NX_P06858	Lipoprotein lipase	475	53162	8.37	0	Cytoplasmic vesicle;Extracellular matrix;Secreted;Cell membrane	Hyperlipidemia, familial combined, 3;Hyperlipoproteinemia 1	Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:8675619, PubMed:11342582, PubMed:27578112). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (PubMed:24726386). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (PubMed:11342582, PubMed:27811232).	Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.	Belongs to the AB hydrolase superfamily. Lipase family.	Glycerolipid metabolism;PPAR signaling pathway;Alzheimer's disease;Retinoid metabolism and transport;Transcriptional regulation of white adipocyte differentiation;Assembly of active LPL and LIPC lipase complexes;Chylomicron remodeling	PE1	8
+NX_P06865	Beta-hexosaminidase subunit alpha	529	60703	5.04	0	Lysosome	GM2-gangliosidosis 1	Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity.	N-linked glycan at Asn-115 consists of Man(3)-GlcNAc(2).	Belongs to the glycosyl hydrolase 20 family.	Other glycan degradation;Amino sugar and nucleotide sugar metabolism;Glycosaminoglycan degradation;Glycosphingolipid biosynthesis - globo series;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Lysosome;Glycosphingolipid metabolism;Keratan sulfate degradation;Hyaluronan uptake and degradation;CS/DS degradation;Defective HEXA causes GM2G1	PE1	15
+NX_P06870	Kallikrein-1	262	28890	4.68	0	NA	NA	Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.	The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.	Belongs to the peptidase S1 family. Kallikrein subfamily.	Endocrine and other factor-regulated calcium reabsorption;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	PE1	19
+NX_P06881	Calcitonin gene-related peptide 1	128	13899	9.18	0	Secreted	NA	CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.	NA	Belongs to the calcitonin family.	G alpha (s) signalling events;Calcitonin-like ligand receptors	PE1	11
+NX_P06899	Histone H2B type 1-J	126	13904	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.;Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.	GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_P07093	Glia-derived nexin	398	44002	9.35	0	Extracellular space	NA	Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.	NA	Belongs to the serpin family.	Common Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation;Dissolution of Fibrin Clot	PE1	2
+NX_P07098	Gastric triacylglycerol lipase	398	45238	6.83	0	Secreted	NA	NA	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Glycerolipid metabolism;Metabolic pathways;Fat digestion and absorption;Digestion of dietary lipid	PE1	10
+NX_P07099	Epoxide hydrolase 1	455	52949	6.77	1	Microsome membrane;Endoplasmic reticulum membrane	Familial hypercholanemia	Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687).	NA	Belongs to the peptidase S33 family.	Metabolism of xenobiotics by cytochrome P450;Bile secretion;Phase I - Functionalization of compounds	PE1	1
+NX_P07101	Tyrosine 3-monooxygenase	528	58600	5.9	0	Cytosol	Segawa syndrome autosomal recessive	Plays an important role in the physiology of adrenergic neurons.	NA	Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.;Tyrosine metabolism;Metabolic pathways;Dopaminergic synapse;Parkinson's disease;Catecholamine biosynthesis	PE1	11
+NX_P07108	Acyl-CoA-binding protein	87	10044	6.12	0	Endoplasmic reticulum;Golgi apparatus	NA	Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.	NA	Belongs to the ACBP family.	PPAR signaling pathway;Mitochondrial Fatty Acid Beta-Oxidation	PE1	2
+NX_P07148	Fatty acid-binding protein, liver	127	14208	6.6	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	PPAR signaling pathway;Fat digestion and absorption;PPARA activates gene expression;Triglyceride catabolism;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PE1	2
+NX_P07195	L-lactate dehydrogenase B chain	334	36638	5.71	0	Cytoplasm;Cytosol	Lactate dehydrogenase B deficiency	NA	NA	Belongs to the LDH/MDH superfamily. LDH family.	Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.;Glycolysis / Gluconeogenesis;Cysteine and methionine metabolism;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Pyruvate metabolism	PE1	12
+NX_P07196	Neurofilament light polypeptide	543	61517	4.64	0	Nucleus speckle;Cytoskeleton	Charcot-Marie-Tooth disease, dominant intermediate G;Charcot-Marie-Tooth disease 2E;Charcot-Marie-Tooth disease 1F	Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.	Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.;O-glycosylated.;Ubiquitinated in the presence of TRIM2 and UBE2D1.;NEFL is phosphorylated by PKN1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the intermediate filament family.	Amyotrophic lateral sclerosis (ALS);RAF/MAP kinase cascade;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	8
+NX_P07197	Neurofilament medium polypeptide	916	102472	4.9	0	Cytoskeleton	NA	Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.	There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.;Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.;Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.;NEFM is phosphorylated by PKN1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the intermediate filament family.	Amyotrophic lateral sclerosis (ALS)	PE1	8
+NX_P07199	Major centromere autoantigen B	599	65171	4.49	0	Nucleoplasm;Centromere;Nucleus	NA	Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable).	N-terminally methylated by METTL11A/NTM1. Alpha-N-methylation is stimulated in response to extracellular stimuli, including increased cell density and heat shock, and seems to facilitate binding to CENP-B boxes. Chromatin-bound CENP-B is primarily trimethylated.;Poly-ADP-ribosylated by PARP1.	NA	NA	PE1	20
+NX_P07202	Thyroid peroxidase	933	102963	6.32	1	Cell surface;Membrane	Thyroid dyshormonogenesis 2A	Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).	Cleaved in its N-terminal part.;Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.;Glycosylated.	Belongs to the peroxidase family. XPO subfamily.	Hormone biosynthesis; thyroid hormone biosynthesis.;Tyrosine metabolism;Metabolic pathways;Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Autoimmune thyroid disease;Thyroxine biosynthesis	PE1	2
+NX_P07203	Glutathione peroxidase 1	203	22088	6.15	0	Cytoplasm	NA	Protects the hemoglobin in erythrocytes from oxidative breakdown.	During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.	Belongs to the glutathione peroxidase family.	Glutathione metabolism;Arachidonic acid metabolism;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Purine catabolism;Detoxification of Reactive Oxygen Species;Synthesis of 15-eicosatetraenoic acid derivatives;Synthesis of 12-eicosatetraenoic acid derivatives;Synthesis of 5-eicosatetraenoic acids	PE1	3
+NX_P07204	Thrombomodulin	575	60329	4.78	1	Membrane;Nucleoplasm;Cytosol	Thrombophilia due to thrombomodulin defect;Hemolytic uremic syndrome atypical 6	Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.	N-glycosylated.;The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.	NA	Complement and coagulation cascades;Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall	PE1	20
+NX_P07205	Phosphoglycerate kinase 2	417	44796	8.74	0	Cytoplasm	NA	Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity).	NA	Belongs to the phosphoglycerate kinase family.	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.;Glycolysis / Gluconeogenesis;Metabolic pathways;Glycolysis;Gluconeogenesis	PE1	6
+NX_P07225	Vitamin K-dependent protein S	676	75123	5.48	0	Secreted	Thrombophilia due to protein S deficiency, autosomal recessive;Thrombophilia due to protein S deficiency, autosomal dominant	Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.	NA	Complement and coagulation cascades;Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Platelet degranulation;Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins	PE1	3
+NX_P07237	Protein disulfide-isomerase	508	57116	4.76	0	Endoplasmic reticulum;Endoplasmic reticulum lumen;Melanosome;Cell membrane	Cole-Carpenter syndrome 1	This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).	NA	Belongs to the protein disulfide isomerase family.	Protein processing in endoplasmic reticulum;Hedgehog ligand biogenesis;Detoxification of Reactive Oxygen Species;Collagen biosynthesis and modifying enzymes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);VLDL assembly;Post-translational protein phosphorylation;Chylomicron assembly;Interleukin-12 signaling;Interleukin-23 signaling	PE1	17
+NX_P07288	Prostate-specific antigen	261	28741	7.61	0	Secreted	NA	Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.	NA	Belongs to the peptidase S1 family. Kallikrein subfamily.	Pathways in cancer;Prostate cancer;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	PE1	19
+NX_P07305	Histone H1.0	194	20863	10.84	0	Golgi apparatus;Chromosome;Nucleoplasm;Nucleus;Cytoskeleton	NA	Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.	Phosphorylated on Ser-17 in RNA edited version.;ADP-ribosylated on Ser-104 in response to DNA damage.	Belongs to the histone H1/H5 family.	Formation of Senescence-Associated Heterochromatin Foci (SAHF);Apoptosis induced DNA fragmentation	PE1	22
+NX_P07306	Asialoglycoprotein receptor 1	291	33186	5.28	1	Membrane;Cytoplasmic vesicle;Cell junction;Secreted	NA	Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.	Phosphorylated on a cytoplasmic Ser residue.	NA	Asparagine N-linked glycosylation	PE1	17
+NX_P07307	Asialoglycoprotein receptor 2	311	35092	5.81	1	Membrane;Endoplasmic reticulum;Cell membrane	NA	Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.	NA	NA	Asparagine N-linked glycosylation	PE1	17
+NX_P07311	Acylphosphatase-1	99	11261	9.3	0	Nucleoplasm;Cytosol	NA	Its physiological role is not yet clear.	NA	Belongs to the acylphosphatase family.	Pyruvate metabolism	PE1	14
+NX_P07315	Gamma-crystallin C	174	20879	6.88	0	NA	Cataract 2, multiple types	Crystallins are the dominant structural components of the vertebrate eye lens.	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	2
+NX_P07316	Gamma-crystallin B	175	20908	6.88	0	NA	Cataract 39, multiple types	Crystallins are the dominant structural components of the vertebrate eye lens.	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	2
+NX_P07320	Gamma-crystallin D	174	20738	7	0	Cytoskeleton;Cell membrane	Cataract 4, multiple types	Crystallins are the dominant structural components of the vertebrate eye lens.	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	2
+NX_P07327	Alcohol dehydrogenase 1A	375	39859	8.26	0	Cytoplasm	NA	NA	NA	Belongs to the zinc-containing alcohol dehydrogenase family.	Glycolysis / Gluconeogenesis;Fatty acid metabolism;Tyrosine metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;RA biosynthesis pathway;Abacavir metabolism;Ethanol oxidation	PE1	4
+NX_P07332	Tyrosine-protein kinase Fes/Fps	822	93497	6.27	0	Golgi apparatus;Cell membrane;Focal adhesion;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Cytoskeleton	NA	Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.	Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK.;FES is phosphorylated by HCK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	Axon guidance;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Signaling by SCF-KIT;Sema3A PAK dependent Axon repulsion;CRMPs in Sema3A signaling	PE1	15
+NX_P07333	Macrophage colony-stimulating factor 1 receptor	972	107984	5.93	1	Cytoplasmic vesicle;Cell membrane	Leukoencephalopathy, diffuse hereditary, with spheroids	Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.	Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation.;Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-561 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-561 and Tyr-809 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-699 and Tyr-923 is important for interaction with GRB2. Phosphorylation at Tyr-723 is important for interaction with PIK3R1. Phosphorylation at Tyr-708 is important for normal receptor degradation. Phosphorylation at Tyr-723 and Tyr-809 is important for interaction with PLCG2. Phosphorylation at Tyr-969 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation.	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Cytokine-cytokine receptor interaction;Endocytosis;Osteoclast differentiation;Hematopoietic cell lineage;Pathways in cancer;Other interleukin signaling	PE1	5
+NX_P07339	Cathepsin D	412	44552	6.1	0	Extracellular space;Melanosome;Lysosome	Ceroid lipofuscinosis, neuronal, 10	Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.	N- and O-glycosylated.;Undergoes proteolytic cleavage and activation by ADAM30.;As well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified (PubMed:1426530). An additional form starting at Ala-168 has also been identified (PubMed:27333034).	Belongs to the peptidase A1 family.	Lysosome;Tuberculosis;MHC class II antigen presentation;Collagen degradation;Metabolism of Angiotensinogen to Angiotensins;Neutrophil degranulation;Estrogen-dependent gene expression	PE1	11
+NX_P07355	Annexin A2	339	38604	7.57	0	Basement membrane;Cytosol;Melanosome;Cell membrane	NA	Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).	Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.;ISGylated.	Belongs to the annexin family.	Smooth Muscle Contraction;Dissolution of Fibrin Clot;Neutrophil degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	15
+NX_P07357	Complement component C8 alpha chain	584	65163	6.07	0	Secreted;Cell membrane	Complement component 8 deficiency, 1	Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.	NA	Belongs to the complement C6/C7/C8/C9 family.	Complement and coagulation cascades;Prion diseases;Amoebiasis;Systemic lupus erythematosus;Terminal pathway of complement;Regulation of Complement cascade	PE1	1
+NX_P07358	Complement component C8 beta chain	591	67047	8.5	0	Secreted	Complement component 8 deficiency, 2	Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.	N-glycosylated; contains one or two bound glycans. Not O-glycosylated.	Belongs to the complement C6/C7/C8/C9 family.	Complement and coagulation cascades;Prion diseases;Amoebiasis;Systemic lupus erythematosus;Terminal pathway of complement;Regulation of Complement cascade	PE1	1
+NX_P07359	Platelet glycoprotein Ib alpha chain	652	71540	5.87	1	Membrane	Pseudo-von Willebrand disease;Non-arteritic anterior ischemic optic neuropathy;Bernard-Soulier syndrome;Bernard-Soulier syndrome A2, autosomal dominant	GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.	Glycocalicin is the product of a proteolytic cleavage/shedding, catalyzed by ADAM17, which releases most of the extracellular domain. Binding sites for vWF and thrombin are in this part of the protein.	NA	Platelet Adhesion to exposed collagen;Intrinsic Pathway of Fibrin Clot Formation;GP1b-IX-V activation signalling;Platelet Aggregation (Plug Formation);RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	17
+NX_P07360	Complement component C8 gamma chain	202	22277	8.49	0	Secreted	NA	C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.	NA	Belongs to the calycin superfamily. Lipocalin family.	Complement and coagulation cascades;Prion diseases;Amoebiasis;Systemic lupus erythematosus;Terminal pathway of complement;Regulation of Complement cascade	PE1	9
+NX_P07384	Calpain-1 catalytic subunit	714	81890	5.49	0	Cytoplasm;Cytosol;Cell membrane	Spastic paraplegia 76, autosomal recessive	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.	Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.	Belongs to the peptidase C2 family.	Protein processing in endoplasmic reticulum;Apoptosis;Alzheimer's disease;Degradation of the extracellular matrix;Neutrophil degranulation;Formation of the cornified envelope;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	PE1	11
+NX_P07437	Tubulin beta chain	444	49671	4.78	0	Cytoplasm;Cytoskeleton	Cortical dysplasia, complex, with other brain malformations 6;Skin creases, congenital symmetric circumferential, 1	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;TUBB is phosphorylated by ABL2 (Phosphotyrosine:PTM-0255);TUBB is phosphorylated by GRK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2;Neutrophil degranulation	PE1	6
+NX_P07438	Metallothionein-1B	61	6115	8.47	0	NA	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	NA	Belongs to the metallothionein superfamily. Type 1 family.	Mineral absorption;Metallothioneins bind metals	PE1	16
+NX_P07451	Carbonic anhydrase 3	260	29557	6.86	0	Cytoplasm	NA	Reversible hydration of carbon dioxide.	S-glutathionylated in hepatocytes under oxidative stress.	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Reversible hydration of carbon dioxide	PE1	8
+NX_P07476	Involucrin	585	68479	4.62	0	Cytoplasm;Cytosol;Centrosome;Nucleus	NA	Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.	Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.	Belongs to the involucrin family.	Formation of the cornified envelope	PE1	1
+NX_P07477	Trypsin-1	247	26558	6.08	0	Extracellular space	Pancreatitis, hereditary	Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.	Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.;Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.	Belongs to the peptidase S1 family.	Neuroactive ligand-receptor interaction;Pancreatic secretion;Protein digestion and absorption;Influenza A;Cobalamin (Cbl, vitamin B12) transport and metabolism;Activation of Matrix Metalloproteinases	PE1	7
+NX_P07478	Trypsin-2	247	26488	4.78	0	Extracellular space	NA	In the ileum, may be involved in defensin processing, including DEFA5.	Sulfated on tyrosine.;Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.	Belongs to the peptidase S1 family.	Neuroactive ligand-receptor interaction;Pancreatic secretion;Protein digestion and absorption;Influenza A;Alpha-defensins;Collagen degradation;Activation of Matrix Metalloproteinases;Neutrophil degranulation;Antimicrobial peptides	PE1	7
+NX_P07492	Gastrin-releasing peptide	148	16213	10.22	0	Secretory vesicle lumen;Secreted	NA	Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity).	NA	Belongs to the bombesin/neuromedin-B/ranatensin family.	Peptide ligand-binding receptors;G alpha (q) signalling events;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	PE1	18
+NX_P07498	Kappa-casein	182	20305	8.97	0	Secreted	NA	Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.	The N-terminus is blocked.	Belongs to the kappa-casein family.	Miscellaneous transport and binding events	PE1	4
+NX_P07510	Acetylcholine receptor subunit gamma	517	57883	5.86	4	Postsynaptic cell membrane;Cell membrane	Multiple pterygium syndrome, lethal type;Multiple pterygium syndrome, Escobar variant	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily.	Neuroactive ligand-receptor interaction;Highly sodium permeable acetylcholine nicotinic receptors	PE1	2
+NX_P07550	Beta-2 adrenergic receptor	413	46459	6.59	7	Cytosol;Early endosome;Cell membrane	NA	Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.	Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.;Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.;Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.;Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation (PubMed:19424180, PubMed:20559325). Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent.;Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.;ADRB2 is phosphorylated by GRK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Endocytosis;Salivary secretion;G alpha (s) signalling events;Adrenoceptors;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	5
+NX_P07585	Decorin	359	39747	8.75	0	Extracellular matrix	Corneal dystrophy, congenital stromal	May affect the rate of fibrils formation.	The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	TGF-beta signaling pathway;Degradation of the extracellular matrix;Chondroitin sulfate biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;ECM proteoglycans;Dermatan sulfate biosynthesis;CS/DS degradation;Defective CHST3 causes SEDCJD;Defective CHST14 causes EDS, musculocontractural type;Defective CHSY1 causes TPBS;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	12
+NX_P07602	Prosaposin	524	58113	5.06	0	Cytoplasmic vesicle;Secreted;Lysosome	Gaucher disease, atypical, due to saposin C deficiency;Krabbe disease, atypical, due to saposin A deficiency;Metachromatic leukodystrophy due to saposin-B deficiency;Combined saposin deficiency	Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).;Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.;Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.;Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.;Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.	The one residue extended Saposin-B-Val is only found in 5% of the chains.;N-linked glycans show a high degree of microheterogeneity.;The lysosomal precursor is proteolytically processed to 4 small peptides, which are similar to each other and are sphingolipid hydrolase activator proteins.	NA	Lysosome;G alpha (i) signalling events;Peptide ligand-binding receptors;Glycosphingolipid metabolism;Platelet degranulation;Neutrophil degranulation	PE1	10
+NX_P07686	Beta-hexosaminidase subunit beta	556	63111	6.29	0	Lysosome	GM2-gangliosidosis 2	Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.	N-linked glycans at Asn-142 and Asn-190 consist of Man(3)-GlcNAc(2) and Man(5 to 7)-GlcNAc(2), respectively.;The beta-A and beta-B chains are produced by proteolytic processing of the precursor beta chain.	Belongs to the glycosyl hydrolase 20 family.	Other glycan degradation;Amino sugar and nucleotide sugar metabolism;Glycosaminoglycan degradation;Glycosphingolipid biosynthesis - globo series;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Lysosome;Glycosphingolipid metabolism;Keratan sulfate degradation;Hyaluronan uptake and degradation;CS/DS degradation;Neutrophil degranulation;Defective HEXB causes GM2G2	PE1	5
+NX_P07711	Cathepsin L1	333	37564	5.32	0	Golgi apparatus;Lysosome;Cytoplasmic vesicle	NA	Important for the overall degradation of proteins in lysosomes.	NA	Belongs to the peptidase C1 family.	Lysosome;Phagosome;Antigen processing and presentation;Rheumatoid arthritis;Degradation of the extracellular matrix;MHC class II antigen presentation;Endosomal/Vacuolar pathway;Collagen degradation;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	PE1	9
+NX_P07737	Profilin-1	140	15054	8.44	0	Cytoplasm;Cytosol;Cytoskeleton	Amyotrophic lateral sclerosis 18	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.	Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.	Belongs to the profilin family.	Regulation of actin cytoskeleton;Shigellosis;Salmonella infection;RHO GTPases Activate Formins;PCP/CE pathway;Platelet degranulation;Signaling by ROBO receptors	PE1	17
+NX_P07738	Bisphosphoglycerate mutase	259	30005	6.1	0	Nucleoplasm;Nucleolus	Erythrocytosis, familial, 8	Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity.	Glycation of Lys-159 in diabetic patients inactivates the enzyme.	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.	Glycolysis / Gluconeogenesis;Metabolic pathways;Glycolysis	PE1	7
+NX_P07741	Adenine phosphoribosyltransferase	180	19608	5.78	0	Nucleoplasm;Cytoplasm;Cytosol	Adenine phosphoribosyltransferase deficiency	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	NA	Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.;Purine metabolism;Metabolic pathways;Purine salvage;Neutrophil degranulation	PE1	16
+NX_P07766	T-cell surface glycoprotein CD3 epsilon chain	207	23147	6.32	1	Cell membrane	Immunodeficiency 18	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).	Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.	NA	Hematopoietic cell lineage;T cell receptor signaling pathway;Chagas disease (American trypanosomiasis);Measles;HTLV-I infection;Primary immunodeficiency;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	11
+NX_P07814	Bifunctional glutamate/proline--tRNA ligase	1512	170591	7.02	0	Membrane;Cytoplasm;Cytosol	Leukodystrophy, hypomyelinating, 15	Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (PubMed:1756734, PubMed:24100331, PubMed:23263184). The phosphorylation of EPRS, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it to the GAIT complex that binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin), suppressing their translation. Interferon-gamma can therefore redirect, in specific cells, the EPRS function from protein synthesis to translation inhibition (PubMed:15479637, PubMed:23071094). Also functions as an effector of the mTORC1 signaling pathway by promoting, through SLC27A1, the uptake of long-chain fatty acid by adipocytes. Thereby, it also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239).	Phosphorylated at Ser-886 by CDK5 (PubMed:19647514, PubMed:21220307). Phosphorylated at Ser-999 by RPS6KB1; triggers EPRS release from the aminoacyl-tRNA synthetase multienzyme complex (PubMed:19647514, PubMed:21220307, PubMed:28178239). In monocytes, the IFN-gamma-induced sequential phosphorylation at Ser-886 and Ser-999 releases EPRS from the aminoacyl-tRNA synthetase multienzyme complex, allowing its association with the GAIT complex. Phosphorylation at Ser-999 is specifically required for the RPL13A-mediated interaction of the GAIT complex with eIF4G (PubMed:19647514, PubMed:21220307). Phosphorylation at Ser-999 by RPS6KB1, is also induced by insulin through activation of the mTORC1 signaling pathway and promotes the interaction of EPRS with SLC27A1 (PubMed:28178239).	In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.;In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.	Porphyrin and chlorophyll metabolism;Aminoacyl-tRNA biosynthesis;Metabolic pathways;Cytosolic tRNA aminoacylation;tRNA modification in the nucleus and cytosol;Selenoamino acid metabolism	PE1	1
+NX_P07858	Cathepsin B	339	37822	5.88	0	Nucleolus;Melanosome;Extracellular space;Cytoplasmic vesicle;Lysosome	Keratolytic winter erythema	Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Has also been implicated in tumor invasion and metastasis (PubMed:3972105).	NA	Belongs to the peptidase C1 family.	Lysosome;Antigen processing and presentation;MHC class II antigen presentation;Collagen degradation;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;Neutrophil degranulation	PE1	8
+NX_P07864	L-lactate dehydrogenase C chain	332	36311	7.08	0	Cytoplasm	NA	Possible role in sperm motility.	NA	Belongs to the LDH/MDH superfamily. LDH family.	Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.;Glycolysis / Gluconeogenesis;Cysteine and methionine metabolism;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Pyruvate metabolism	PE1	11
+NX_P07900	Heat shock protein HSP 90-alpha	732	84660	4.94	0	Cytoplasm;Cell membrane;Melanosome;Cytosol;Nucleus	NA	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).	Ubiquitinated via 'Lys-63'-linked polyubiquitination by HECTD1. Ubiquitination promotes translocation into the cytoplasm away from the membrane and secretory pathways.;S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.;ISGylated.;HSP90AA1 is phosphorylated by PRKDC	Belongs to the heat shock protein 90 family.	Protein processing in endoplasmic reticulum;Antigen processing and presentation;NOD-like receptor signaling pathway;Progesterone-mediated oocyte maturation;Pathways in cancer;Prostate cancer;Anchoring of the basal body to the plasma membrane;Regulation of actin dynamics for phagocytic cup formation;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;PIWI-interacting RNA (piRNA) biogenesis;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Signaling by ERBB2;Uptake and function of diphtheria toxin;Attenuation phase;HSF1-dependent transactivation;Sema3A PAK dependent Axon repulsion;HSF1 activation;Recruitment of NuMA to mitotic centrosomes;eNOS activation;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Scavenging by Class F Receptors;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Constitutive Signaling by EGFRvIII;vRNP Assembly;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Neutrophil degranulation;Downregulation of ERBB2 signaling;Interleukin-4 and Interleukin-13 signaling;HSP90 chaperone cycle for steroid hormone receptors (SHR);Estrogen-dependent gene expression;ESR-mediated signaling;Extra-nuclear estrogen signaling;Chaperone Mediated Autophagy	PE1	14
+NX_P07902	Galactose-1-phosphate uridylyltransferase	379	43363	6.49	0	Cytosol	Galactosemia	Plays an important role in galactose metabolism.	NA	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.	Carbohydrate metabolism; galactose metabolism.;Galactose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Galactose catabolism;Defective GALT can cause Galactosemia	PE1	9
+NX_P07910	Heterogeneous nuclear ribonucleoproteins C1/C2	306	33670	4.95	0	Nucleoplasm;Nucleus	NA	Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).	Sumoylated. Sumoylation reduces affinity for mRNA.;Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.	Belongs to the RRM HNRPC family. RALY subfamily.	Spliceosome;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;SUMOylation of RNA binding proteins	PE1	14
+NX_P07911	Uromodulin	640	69761	5.05	0	Cilium membrane;Basolateral cell membrane;Apical cell membrane;Secreted	Glomerulocystic kidney disease with hyperuricemia and isosthenuria;Medullary cystic kidney disease 2;Familial juvenile hyperuricemic nephropathy 1	Uromodulin, secreted form: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.;Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515).	N-glycosylated (PubMed:19005207, PubMed:26673890, PubMed:26811476). N-glycan heterogeneity at Asn-232: Hex7HexNAc6 (major) and dHex1Hex7HexNAc6 (minor); at Asn-322: dHex1Hex6HexNAc5 (minor), dHex1Hex7HexNAc6 (major) and dHex1Hex8HexNAc7 (minor); at Asn-396: Hex6HexNAc5 (major), dHex1Hex6HexNAc5 (minor) and Hex7HexNAc6 (minor) (PubMed:22171320).;Proteolytically cleaved at a conserved C-terminal proteolytic cleavage site to generate the secreted form found in urine (PubMed:18375198, PubMed:19005207). This cleavage is catalyzed by HPN (PubMed:26673890).	NA	Asparagine N-linked glycosylation	PE1	16
+NX_P07919	Cytochrome b-c1 complex subunit 6, mitochondrial	91	10739	4.39	0	Mitochondrion inner membrane	NA	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.	NA	Belongs to the UQCRH/QCR6 family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport	PE1	1
+NX_P07942	Laminin subunit beta-1	1786	198038	4.83	0	Basement membrane	Lissencephaly 5	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.	NA	NA	Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer;Degradation of the extracellular matrix;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Non-integrin membrane-ECM interactions;L1CAM interactions;Laminin interactions;MET activates PTK2 signaling;Post-translational protein phosphorylation	PE1	7
+NX_P07947	Tyrosine-protein kinase Yes	543	60801	6.32	0	Cytosol;Centrosome;Cell membrane	NA	Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.	Palmitoylation at Cys-3 promotes membrane localization.;Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition.;YES1 is phosphorylated by FLT1 (Phosphotyrosine:PTM-0255);YES1 is phosphorylated by CSK (Phosphotyrosine:PTM-0255);Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.	Adherens junction;Tight junction;EPH-Ephrin signaling;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse;Signaling by ERBB2;Signaling by SCF-KIT;Regulation of KIT signaling;CD28 co-stimulation;FCGR activation;PECAM1 interactions;CTLA4 inhibitory signaling;Regulation of signaling by CBL;RUNX2 regulates osteoblast differentiation	PE1	18
+NX_P07948	Tyrosine-protein kinase Lyn	512	58574	6.7	0	Golgi apparatus;Cytoplasm;Cell membrane;Membrane;Cytoplasmic vesicle;Perinuclear region;Nucleus	NA	Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity).	Autophosphorylated. Phosphorylated on tyrosine residues in response to KIT signaling. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylation at Tyr-508 inhibits kinase activity. Phosphorylated at Tyr-508 by CSK. Dephosphorylated by PTPRC/CD45. Becomes rapidly phosphorylated upon activation of the B-cell receptor and the immunoglobulin receptor FCGR1A.;Ubiquitinated by CBL, leading to its degradation. Ubiquitination is SH3-dependent.	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.	Chemokine signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Long-term depression;Epithelial cell signaling in Helicobacter pylori infection;FCERI mediated NF-kB activation;Role of LAT2/NTAL/LAB on calcium mobilization;GPVI-mediated activation cascade;EPH-Ephrin signaling;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;EPHA-mediated growth cone collapse;Cell surface interactions at the vascular wall;Growth hormone receptor signaling;Signaling by SCF-KIT;Regulation of KIT signaling;CD28 co-stimulation;Dectin-2 family;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CD209 (DC-SIGN) signaling;Cyclin D associated events in G1;FCGR activation;Fc epsilon receptor (FCERI) signaling;PECAM1 interactions;CTLA4 inhibitory signaling;Platelet Adhesion to exposed collagen;Regulation of signaling by CBL;CD22 mediated BCR regulation;Erythropoietin activates RAS;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Signaling by Erythropoietin;Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5	PE1	8
+NX_P07949	Proto-oncogene tyrosine-protein kinase receptor Ret	1114	124319	6.17	1	Golgi apparatus;Cytosol;Endosome membrane;Cell membrane	Hirschsprung disease 1;Pheochromocytoma;Congenital central hypoventilation syndrome;Multiple neoplasia 2A;Multiple neoplasia 2B;Medullary thyroid carcinoma;Colorectal cancer	In complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL (PubMed:28846099).;Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways (PubMed:28846097, PubMed:28953886, PubMed:28846099).	Proteolytically cleaved by caspase-3. The soluble RET kinase fragment is able to induce cell death. The extracellular cell-membrane anchored RET cadherin fragment accelerates cell adhesion in sympathetic neurons.;Autophosphorylated on C-terminal tyrosine residues upon ligand stimulation. Dephosphorylated by PTPRJ on Tyr-905, Tyr-1015 and Tyr-1062.	Belongs to the protein kinase superfamily. Tyr protein kinase family.	Endocytosis;Pathways in cancer;Thyroid cancer;RAF/MAP kinase cascade;RET signaling	PE1	10
+NX_P07951	Tropomyosin beta chain	284	32851	4.66	0	Cytoplasm;Cytoskeleton	Arthrogryposis, distal, 2B4;Cap myopathy 2;Arthrogryposis, distal, 1A;Nemaline myopathy 4	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.	Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity).	Belongs to the tropomyosin family.	Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Striated Muscle Contraction;Smooth Muscle Contraction	PE1	9
+NX_P07954	Fumarate hydratase, mitochondrial	510	54637	8.85	0	Cytosol;Mitochondrion;Nucleus;Chromosome	Fumarase deficiency;Hereditary leiomyomatosis and renal cell cancer	Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.;Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable).;Catalyzes the dehydration of L-malate to fumarate (By similarity). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed:20231875, PubMed:26237645). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (PubMed:26237645).	Phosphorylation at Thr-236 by PRKDC in response to DNA damage promotes translocation to the nucleus and recruitment to DNA double-strand breaks (DSBs).	Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.;Citrate cycle (TCA cycle);Metabolic pathways;Pathways in cancer;Renal cell carcinoma;Citric acid cycle (TCA cycle)	PE1	1
+NX_P07988	Pulmonary surfactant-associated protein B	381	42117	5.27	0	Surface film	Pulmonary surfactant metabolism dysfunction 1;Respiratory distress syndrome in premature infants	Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	NA	NA	Surfactant metabolism;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4);Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)	PE1	2
+NX_P07992	DNA excision repair protein ERCC-1	297	32562	5.9	0	Nucleoplasm;Cytoplasm;Nucleus	Cerebro-oculo-facio-skeletal syndrome 4	Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.	NA	Belongs to the ERCC1/RAD10/SWI10 family.	Nucleotide excision repair;Fanconi anemia pathway;Dual incision in TC-NER;HDR through Single Strand Annealing (SSA);Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;Fanconi Anemia Pathway	PE1	19
+NX_P07996	Thrombospondin-1	1170	129383	4.71	0	Extracellular matrix;Cell membrane;Secreted;Cell surface;Endoplasmic reticulum;Sarcoplasmic reticulum	NA	Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).	NA	Belongs to the thrombospondin family.	p53 signaling pathway;Phagosome;TGF-beta signaling pathway;Focal adhesion;ECM-receptor interaction;Malaria;Bladder cancer;O-glycosylation of TSR domain-containing proteins;Signaling by PDGF;Syndecan interactions;Integrin cell surface interactions;Platelet degranulation;Defective B3GALTL causes Peters-plus syndrome (PpS);RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	15
+NX_P07998	Ribonuclease pancreatic	156	17644	9.1	0	Nucleoplasm;Secreted;Cytoplasmic vesicle	NA	Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.	N-linked glycans are of complex type.	Belongs to the pancreatic ribonuclease family.	Chaperone Mediated Autophagy;Microautophagy	PE1	14
+NX_P08034	Gap junction beta-1 protein	283	32025	9.19	4	Gap junction;Cell membrane	Charcot-Marie-Tooth disease, X-linked dominant, 1;Dejerine-Sottas syndrome	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Beta-type (group I) subfamily.	Gap junction assembly;Oligomerization of connexins into connexons;Transport of connexins along the secretory pathway	PE1	X
+NX_P08047	Transcription factor Sp1	785	80693	6.94	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).;Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.	Proteolytic cleavage in the N-terminal repressor domain is prevented by sumoylation. The C-terminal cleaved product is susceptible to degradation.;Sumoylated with SUMO1. Sumoylation modulates proteolytic cleavage of the N-terminal repressor domain. Sumoylation levels are attenuated during tumorigenesis. Phosphorylation mediates SP1 desumoylation.;Acetylated. Acetylation/deacetylation events affect transcriptional activity. Deacetylation leads to an increase in the expression the 12(s)-lipooxygenase gene though recruitment of p300 to the promoter.;Ubiquitinated. Ubiquitination occurs on the C-terminal proteolytically-cleaved peptide and is triggered by phosphorylation.;O-glycosylated; Contains 8 N-acetylglucosamine side chains. Levels are controlled by insulin and the SP1 phosphorylation states. Insulin-mediated O-glycosylation locates SP1 to the nucleus, where it is sequentially deglycosylated and phosphorylated. O-glycosylation affects transcriptional activity through disrupting the interaction with a number of transcription factors including ELF1 and NFYA. Also inhibits interaction with the HIV1 promoter. Inhibited by peroxisomome proliferator receptor gamma (PPARgamma).;Phosphorylated on multiple serine and threonine residues. Phosphorylation is coupled to ubiquitination, sumoylation and proteolytic processing. Phosphorylation on Ser-59 enhances proteolytic cleavage. Phosphorylation on Ser-7 enhances ubiquitination and protein degradation. Hyperphosphorylation on Ser-101 in response to DNA damage has no effect on transcriptional activity. MAPK1/MAPK3-mediated phosphorylation on Thr-453 and Thr-739 enhances VEGF transcription but, represses FGF2-triggered PDGFR-alpha transcription. Also implicated in the repression of RECK by ERBB2. Hyperphosphorylated on Thr-278 and Thr-739 during mitosis by MAPK8 shielding SP1 from degradation by the ubiquitin-dependent pathway. Phosphorylated in the zinc-finger domain by calmodulin-activated PKCzeta. Phosphorylation on Ser-641 by PKCzeta is critical for TSA-activated LHR gene expression through release of its repressor, p107. Phosphorylation on Thr-668, Ser-670 and Thr-681 is stimulated by angiotensin II via the AT1 receptor inducing increased binding to the PDGF-D promoter. This phosphorylation is increased in injured artey wall. Ser-59 and Thr-681 can both be dephosphorylated by PP2A during cell-cycle interphase. Dephosphorylation on Ser-59 leads to increased chromatin association during interphase and increases the transcriptional activity. On insulin stimulation, sequentially glycosylated and phosphorylated on several C-terminal serine and threonine residues.	Belongs to the Sp1 C2H2-type zinc-finger protein family.	PPARA activates gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Activation of gene expression by SREBF (SREBP);Oncogene Induced Senescence;RNA polymerase II transcribes snRNA genes;Estrogen-dependent gene expression	PE1	12
+NX_P08048	Zinc finger Y-chromosomal protein	801	90505	5.65	0	Nucleus	NA	Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.	NA	PE1	Y
+NX_P08069	Insulin-like growth factor 1 receptor	1367	154793	5.58	1	Cytoplasmic vesicle;Cell membrane	Insulin-like growth factor 1 resistance	When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.;Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.	Sumoylated with SUMO1.;Controlled by regulated intramembrane proteolysis (RIP). Undergoes metalloprotease-dependent constitutive ectodomain shedding to produce a membrane-anchored 52 kDa C-Terminal fragment which is further processed by presenilin gamma-secretase to yield an intracellular 50 kDa fragment.;Polyubiquitinated at Lys-1168 and Lys-1171 through both 'Lys-48' and 'Lys-29' linkages, promoting receptor endocytosis and subsequent degradation by the proteasome. Ubiquitination is facilitated by pre-existing phosphorylation.;Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. One subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation occurs in a sequential manner; Tyr-1165 is predominantly phosphorylated first, followed by phosphorylation of Tyr-1161 and Tyr-1166. While every single phosphorylation increases kinase activity, all three tyrosine residues in the kinase activation loop (Tyr-1165, Tyr-1161 and Tyr-1166) have to be phosphorylated for optimal activity. Can be autophosphorylated at additional tyrosine residues (in vitro). Autophosphorylated is followed by phosphorylation of juxtamembrane tyrosines and C-terminal serines. Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding. Phosphorylation of Ser-1278 by GSK-3beta restrains kinase activity and promotes cell surface expression, it requires a priming phosphorylation at Ser-1282. Dephosphorylated by PTPN1 (By similarity).;IGF1R is phosphorylated by PTK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	Oocyte meiosis;Endocytosis;Focal adhesion;Adherens junction;Long-term depression;Progesterone-mediated oocyte maturation;Pathways in cancer;Glioma;Prostate cancer;Melanoma;IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);Extra-nuclear estrogen signaling	PE1	15
+NX_P08100	Rhodopsin	348	38893	6.21	7	Membrane;Photoreceptor outer segment;Cell membrane	Night blindness, congenital stationary, autosomal dominant 1;Retinitis pigmentosa 4	Photoreceptor required for image-forming vision at low light intensity (PubMed:8107847, PubMed:7846071). Required for photoreceptor cell viability after birth (PubMed:2215617, PubMed:12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:8107847, PubMed:28524165, PubMed:26200343, PubMed:28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:28524165, PubMed:26200343).	Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal(PubMed:12566452).;Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region (By similarity). After activation by light, phosphorylated by GRK1 (in vitro) (PubMed:28524165).;RHO is phosphorylated by GRK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);RHO is phosphorylated by GRK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);RHO is phosphorylated by GRK7	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	Phototransduction;G alpha (i) signalling events;VxPx cargo-targeting to cilium;The canonical retinoid cycle in rods (twilight vision);Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Opsins	PE1	3
+NX_P08118	Beta-microseminoprotein	114	12865	5.36	0	Secreted	Prostate cancer, hereditary, 13	NA	NA	Belongs to the beta-microseminoprotein family.	NA	PE1	10
+NX_P08123	Collagen alpha-2(I) chain	1366	129314	9.08	0	Endoplasmic reticulum;Extracellular matrix	Ehlers-Danlos syndrome, cardiac valvular type;Osteogenesis imperfecta 3;Osteogenesis imperfecta 4;Osteogenesis imperfecta 1;Osteogenesis imperfecta 2;Ehlers-Danlos syndrome, arthrochalasia type, 2	Type I collagen is a member of group I collagen (fibrillar forming collagen).	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the fibrillar collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;GPVI-mediated activation cascade;Collagen degradation;Collagen biosynthesis and modifying enzymes;Syndecan interactions;Integrin cell surface interactions;Cell surface interactions at the vascular wall;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Scavenging by Class A Receptors;Non-integrin membrane-ECM interactions;Platelet Adhesion to exposed collagen;Crosslinking of collagen fibrils;Anchoring fibril formation;GP1b-IX-V activation signalling;Platelet Aggregation (Plug Formation);Extracellular matrix organization;MET activates PTK2 signaling;Interleukin-4 and Interleukin-13 signaling;Collagen chain trimerization	PE1	7
+NX_P08133	Annexin A6	673	75873	5.42	0	Cytoplasm;Cytosol;Melanosome	NA	May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.	Phosphorylated in response to growth factor stimulation.	Belongs to the annexin family.	Smooth Muscle Contraction	PE1	5
+NX_P08134	Rho-related GTP-binding protein RhoC	193	22006	6.2	0	Cleavage furrow;Cell membrane	NA	Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.	(Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.	Belongs to the small GTPase superfamily. Rho family.	RHO GTPases Activate Rhotekin and Rhophilins;RHO GTPases Activate Formins;Rho GTPase cycle;G alpha (12/13) signalling events;RHO GTPases activate PKNs;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate CIT;RHO GTPases Activate ROCKs	PE1	1
+NX_P08138	Tumor necrosis factor receptor superfamily member 16	427	45183	4.59	1	Dendritic spine;Cell membrane;Growth cone;Perikaryon;Nucleoplasm	NA	Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).	N- and O-glycosylated.;Phosphorylated on serine residues.;O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.	NA	Cytokine-cytokine receptor interaction;Neurotrophin signaling pathway;Axonal growth inhibition (RHOA activation);Axonal growth stimulation;NRAGE signals death through JNK;p75NTR recruits signalling complexes;p75NTR negatively regulates cell cycle via SC1;Regulated proteolysis of p75NTR;NF-kB is activated and signals survival;NRIF signals cell death from the nucleus;NADE modulates death signalling;Ceramide signalling;NFG and proNGF binds to p75NTR	PE1	17
+NX_P08151	Zinc finger protein GLI1	1106	117904	6.98	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Polydactyly, postaxial, A8	Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.;Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407).	Phosphorylated in vitro by ULK3.;Acetylation at Lys-518 down-regulates transcriptional activity. Deacetylated by HDAC1.;GLI1 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the GLI C2H2-type zinc-finger protein family.	Degradation of GLI1 by the proteasome;Hedgehog 'on' state;Hedgehog 'off' state;GLI proteins bind promoters of Hh responsive genes to promote transcription	PE1	12
+NX_P08172	Muscarinic acetylcholine receptor M2	466	51715	9.07	7	Cell membrane;Postsynaptic cell membrane	Major depressive disorder	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.	Phosphorylated in response to agonist treatment.;CHRM2 is phosphorylated by GRK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Cholinergic synapse;Regulation of actin cytoskeleton;G alpha (i) signalling events;Muscarinic acetylcholine receptors;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	7
+NX_P08173	Muscarinic acetylcholine receptor M4	479	53049	9.87	7	Postsynaptic cell membrane;Nucleoplasm;Golgi apparatus;Cell membrane	NA	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.	NA	Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.	Neuroactive ligand-receptor interaction;Cholinergic synapse;Regulation of actin cytoskeleton;G alpha (i) signalling events;Muscarinic acetylcholine receptors	PE1	11
+NX_P08174	Complement decay-accelerating factor	381	41400	7.79	0	Secreted;Cell membrane	Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy	(Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5.;(Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable).;(Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21.;This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829).	The Ser/Thr-rich domain is heavily O-glycosylated.	Belongs to the receptors of complement activation (RCA) family.	Complement and coagulation cascades;Hematopoietic cell lineage;Viral myocarditis;Class B/2 (Secretin family receptors);Regulation of Complement cascade;COPI-mediated anterograde transport;Neutrophil degranulation	PE1	1
+NX_P08183	ATP-dependent translocase ABCB1	1280	141479	9.06	12	Cell membrane;Apical cell membrane;Focal adhesion;Nucleoplasm;Cytosol	Inflammatory bowel disease 13	Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218).	NA	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.	ABC transporters;Bile secretion;Abacavir transmembrane transport;ABC-family proteins mediated transport	PE1	7
+NX_P08185	Corticosteroid-binding globulin	405	45141	5.64	0	Secreted	Corticosteroid-binding globulin deficiency	Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.	Glycosylation in position Asn-260 is needed for steroid binding.;N-glycosylated; binds 5 oligosaccharide chains.	Belongs to the serpin family.	NA	PE1	14
+NX_P08195	4F2 cell-surface antigen heavy chain	630	67994	4.89	1	Cell membrane;Apical cell membrane;Cell junction;Lysosome membrane;Nucleoplasm;Melanosome;Cytosol	NA	Component of several heterodimeric amino acid transporter complexes (PubMed:11557028, PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:11311135). The precise substrate specificity depends on the other subunit in the heterodimer (PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:30867591, PubMed:10903140). The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:11557028, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). The complexes with SLC7A6 and SLC7A7 mediate uptake of dibasic amino acids (PubMed:9829974, PubMed:10903140). The complexes function as amino acid exchangers (PubMed:11557028, PubMed:10903140, PubMed:12117417, PubMed:12225859, PubMed:30867591). Required for targeting of SLC7A5 and SLC7A8 to the plasma membrane and for channel activity (PubMed:9751058, PubMed:11311135, PubMed:30867591). Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). The heterodimer with SLC7A5/LAT1 can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). The heterodimer with SLC7A5 is involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Together with ICAM1, regulates the transport activity SLC7A8 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567).	Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions.	Belongs to the SLC3A transporter family.	Protein digestion and absorption;Tryptophan catabolism;Amino acid transport across the plasma membrane;Basigin interactions;Defective SLC7A7 causes lysinuric protein intolerance (LPI)	PE1	11
+NX_P08217	Chymotrypsin-like elastase family member 2A	269	28888	8.8	0	Secreted	NA	Acts upon elastin.	NA	Belongs to the peptidase S1 family. Elastase subfamily.	Pancreatic secretion;Protein digestion and absorption;Formation of the cornified envelope	PE1	1
+NX_P08218	Chymotrypsin-like elastase family member 2B	269	28810	6.48	0	Secreted	NA	Acts upon elastin.	NA	Belongs to the peptidase S1 family. Elastase subfamily.	Pancreatic secretion;Protein digestion and absorption	PE1	1
+NX_P08235	Mineralocorticoid receptor	984	107082	7.22	0	Cytoplasm;Nucleoplasm;Endoplasmic reticulum membrane;Nucleus	Early-onset hypertension with severe exacerbation in pregnancy;Pseudohypoaldosteronism 1, autosomal dominant	Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.	Phosphorylated.	Belongs to the nuclear hormone receptor family. NR3 subfamily.	Aldosterone-regulated sodium reabsorption;Nuclear Receptor transcription pathway;HSP90 chaperone cycle for steroid hormone receptors (SHR);SUMOylation of intracellular receptors	PE1	4
+NX_P08236	Beta-glucuronidase	651	74732	6.54	0	Cytoplasmic vesicle;Lysosome	Mucopolysaccharidosis 7	Plays an important role in the degradation of dermatan and keratan sulfates.	N-linked glycosylated with 3 to 4 oligosaccharide chains.	Belongs to the glycosyl hydrolase 2 family.	Pentose and glucuronate interconversions;Starch and sucrose metabolism;Glycosaminoglycan degradation;Porphyrin and chlorophyll metabolism;Drug metabolism - other enzymes;Metabolic pathways;Lysosome;Hyaluronan uptake and degradation;HS-GAG degradation;MPS VII - Sly syndrome;Neutrophil degranulation	PE1	7
+NX_P08237	ATP-dependent 6-phosphofructokinase, muscle type	780	85183	8.23	0	Endoplasmic reticulum;Cytoplasm	Glycogen storage disease 7	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.	GlcNAcylation decreases enzyme activity.	Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Fructose and mannose metabolism;Galactose metabolism;Metabolic pathways;Glycolysis	PE1	12
+NX_P08238	Heat shock protein HSP 90-beta	724	83264	4.97	0	Cytoplasm;Cell membrane;Secreted;Melanosome;Nucleus	NA	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone that is involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823).	Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).;S-nitrosylated; negatively regulates the ATPase activity.;Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.;Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.;ISGylated.;Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide (PubMed:23585225). Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction (PubMed:15581363).;HSP90AB1 is phosphorylated by MAPK3	Belongs to the heat shock protein 90 family.	Protein processing in endoplasmic reticulum;Antigen processing and presentation;NOD-like receptor signaling pathway;Progesterone-mediated oocyte maturation;Pathways in cancer;Prostate cancer;Regulation of actin dynamics for phagocytic cup formation;The NLRP3 inflammasome;Uptake and function of diphtheria toxin;Attenuation phase;HSF1-dependent transactivation;Sema3A PAK dependent Axon repulsion;HSF1 activation;The role of GTSE1 in G2/M progression after G2 checkpoint;Neutrophil degranulation;Aryl hydrocarbon receptor signalling;HSP90 chaperone cycle for steroid hormone receptors (SHR);Estrogen-dependent gene expression;ESR-mediated signaling;Chaperone Mediated Autophagy	PE1	6
+NX_P08240	Signal recognition particle receptor subunit alpha	638	69811	9.07	0	Endoplasmic reticulum membrane	NA	Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.	NA	Belongs to the GTP-binding SRP family.	Protein export;XBP1(S) activates chaperone genes;SRP-dependent cotranslational protein targeting to membrane	PE1	11
+NX_P08243	Asparagine synthetase [glutamine-hydrolyzing]	561	64370	6.39	0	Cytosol	Asparagine synthetase deficiency	NA	NA	NA	Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.;Alanine, aspartate and glutamate metabolism;Nitrogen metabolism;Metabolic pathways;ATF4 activates genes in response to endoplasmic reticulum stress;Aspartate and asparagine metabolism	PE1	7
+NX_P08246	Neutrophil elastase	267	28518	9.71	0	Phagosome	Neutropenia, severe congenital 1, autosomal dominant;Cyclic haematopoiesis	Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984).	NA	Belongs to the peptidase S1 family. Elastase subfamily.	Systemic lupus erythematosus;Degradation of the extracellular matrix;Collagen degradation;Regulation of Complement cascade;Activation of Matrix Metalloproteinases;Neutrophil degranulation;Antimicrobial peptides	PE1	19
+NX_P08247	Synaptophysin	313	33845	4.66	4	Synaptic vesicle membrane;Synaptosome	Mental retardation, X-linked 96	Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).	Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.	Belongs to the synaptophysin/synaptobrevin family.	NA	PE1	X
+NX_P08253	72 kDa type IV collagenase	660	73882	5.26	0	Cytoplasm;Mitochondrion;Extracellular matrix;Membrane;Cytoplasmic vesicle;Nucleus	Multicentric osteolysis, nodulosis, and arthropathy	PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.;Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.;Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.	The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta3.;Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro.	Belongs to the peptidase M10A family.	Leukocyte transendothelial migration;GnRH signaling pathway;Pathways in cancer;Bladder cancer;Degradation of the extracellular matrix;EPH-ephrin mediated repulsion of cells;Collagen degradation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Activation of Matrix Metalloproteinases;Interleukin-4 and Interleukin-13 signaling;Extra-nuclear estrogen signaling	PE1	16
+NX_P08254	Stromelysin-1	477	53977	5.77	0	Cytoplasmic vesicle;Extracellular matrix	Coronary heart disease 6	Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.	NA	Belongs to the peptidase M10A family.	Rheumatoid arthritis;Degradation of the extracellular matrix;Collagen degradation;EGFR Transactivation by Gastrin;Assembly of collagen fibrils and other multimeric structures;Activation of Matrix Metalloproteinases;Interleukin-4 and Interleukin-13 signaling;Extra-nuclear estrogen signaling	PE1	11
+NX_P08263	Glutathione S-transferase A1	222	25631	8.91	0	Cytoplasm	NA	Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).	NA	Belongs to the GST superfamily. Alpha family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation	PE1	6
+NX_P08294	Extracellular superoxide dismutase [Cu-Zn]	240	25851	6.13	0	Extracellular space	NA	Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.	NA	Belongs to the Cu-Zn superoxide dismutase family.	Detoxification of Reactive Oxygen Species	PE1	4
+NX_P08311	Cathepsin G	255	28837	11.19	0	Cell surface	NA	Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.	NA	Belongs to the peptidase S1 family.	Neuroactive ligand-receptor interaction;Lysosome;Renin-angiotensin system;Amoebiasis;Systemic lupus erythematosus;Degradation of the extracellular matrix;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Activation of Matrix Metalloproteinases;Metabolism of Angiotensinogen to Angiotensins;Interleukin-1 processing;Neutrophil degranulation;Antimicrobial peptides	PE1	14
+NX_P08319	All-trans-retinol dehydrogenase [NAD(+)] ADH4	380	40222	8.25	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444).	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.	Glycolysis / Gluconeogenesis;Fatty acid metabolism;Tyrosine metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;RA biosynthesis pathway;Ethanol oxidation	PE1	4
+NX_P08397	Porphobilinogen deaminase	361	39330	6.68	0	Cytoplasm;Lipid droplet	Acute intermittent porphyria	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.	NA	Belongs to the HMBS family.	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.;Porphyrin and chlorophyll metabolism;Metabolic pathways;Heme biosynthesis	PE1	11
+NX_P08473	Neprilysin	750	85514	5.54	1	Cell membrane	Spinocerebellar ataxia 43;Charcot-Marie-Tooth disease 2T	Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).	Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.;Myristoylation is a determinant of membrane targeting.	Belongs to the peptidase M13 family.	Renin-angiotensin system;Hematopoietic cell lineage;Protein digestion and absorption;Alzheimer's disease;Metabolism of Angiotensinogen to Angiotensins;Neutrophil degranulation	PE1	3
+NX_P08476	Inhibin beta A chain	426	47442	8.3	0	Secreted	NA	Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.	NA	Belongs to the TGF-beta family.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Glycoprotein hormones;Signaling by Activin;Antagonism of Activin by Follistatin	PE1	7
+NX_P08493	Matrix Gla protein	103	12353	9.71	0	Secreted	Keutel syndrome	Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.	Requires vitamin K-dependent gamma-carboxylation for its function.	Belongs to the osteocalcin/matrix Gla protein family.	NA	PE1	12
+NX_P08514	Integrin alpha-IIb	1039	113377	5.21	1	Membrane;Cell membrane	Bleeding disorder, platelet-type 16;Glanzmann thrombasthenia	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.	NA	Belongs to the integrin alpha chain family.	Focal adhesion;ECM-receptor interaction;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Pathways in cancer;Small cell lung cancer;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Signal transduction by L1;MAP2K and MAPK activation;Integrin cell surface interactions;Platelet degranulation;ECM proteoglycans;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	17
+NX_P08519	Apolipoprotein(a)	4548	501319	5.58	0	NA	NA	Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.	N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected.	Belongs to the peptidase S1 family. Plasminogen subfamily.	LDL remodeling	PE1	6
+NX_P08559	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	390	43296	8.35	0	Mitochondrion matrix	Pyruvate dehydrogenase E1-alpha deficiency	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.	Acetylation alters the phosphorylation pattern. Deacetylated by SIRT3 (By similarity).;Phosphorylation at Ser-232, Ser-293 and Ser-300 by PDK family kinases inactivates the enzyme; for this phosphorylation at a single site is sufficient. Dephosphorylation at all three sites, i.e. At Ser-232, Ser-293 and Ser-300, is required for reactivation.	NA	Glycolysis / Gluconeogenesis;Citrate cycle (TCA cycle);Valine, leucine and isoleucine biosynthesis;Pyruvate metabolism;Butanoate metabolism;Metabolic pathways;Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex;Pyruvate metabolism;Glyoxylate metabolism and glycine degradation	PE1	X
+NX_P08567	Pleckstrin	350	40125	8.51	0	Nucleolus	NA	Major protein kinase C substrate of platelets.	NA	NA	Platelet degranulation	PE1	2
+NX_P08571	Monocyte differentiation antigen CD14	375	40076	5.84	0	Golgi apparatus;Cell membrane;Secreted;Cytoplasmic vesicle;Membrane raft	NA	Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).	N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.	NA	MAPK signaling pathway;Phagosome;Toll-like receptor signaling pathway;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Pathogenic Escherichia coli infection;Salmonella infection;Pertussis;Legionellosis;Amoebiasis;Tuberculosis;ER-Phagosome pathway;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);Toll Like Receptor 4 (TLR4) Cascade;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;Toll Like Receptor TLR1:TLR2 Cascade;Caspase activation via Death Receptors in the presence of ligand;MyD88-independent TLR4 cascade;TRIF-mediated programmed cell death;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Toll Like Receptor TLR6:TLR2 Cascade;Transfer of LPS from LBP carrier to CD14;Regulation of TLR by endogenous ligand;Neutrophil degranulation	PE1	5
+NX_P08572	Collagen alpha-2(IV) chain	1712	167553	8.89	0	Cytoplasmic vesicle;Basement membrane	Intracerebral hemorrhage;Brain small vessel disease 2	Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.;Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.;Proteolytic processing produces the C-terminal NC1 peptide, canstatin.;Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.;The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.	Belongs to the type IV collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Pathways in cancer;Small cell lung cancer;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Scavenging by Class A Receptors;Non-integrin membrane-ECM interactions;Laminin interactions;Crosslinking of collagen fibrils;Anchoring fibril formation;Extracellular matrix organization;Collagen chain trimerization	PE1	13
+NX_P08574	Cytochrome c1, heme protein, mitochondrial	325	35422	9.15	1	Mitochondrion;Nucleoplasm;Cytosol;Mitochondrion inner membrane;Nucleus	Mitochondrial complex III deficiency, nuclear 6	This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.	Binds 1 heme group per subunit.	Belongs to the cytochrome c family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Mitochondrial protein import;Respiratory electron transport	PE1	8
+NX_P08575	Receptor-type tyrosine-protein phosphatase C	1306	147486	5.77	1	Cytoplasmic vesicle;Nucleoplasm;Membrane raft;Cell membrane	Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive;Multiple sclerosis	(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.;Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).	Heavily N- and O-glycosylated.	Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.	Cell adhesion molecules (CAMs);T cell receptor signaling pathway;Fc gamma R-mediated phagocytosis;Primary immunodeficiency;Phosphorylation of CD3 and TCR zeta chains;Other semaphorin interactions;Neutrophil degranulation	PE1	1
+NX_P08579	U2 small nuclear ribonucleoprotein B''	225	25486	9.72	0	Cytosol;Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128).	NA	Belongs to the RRM U1 A/B'' family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	20
+NX_P08581	Hepatocyte growth factor receptor	1390	155541	7.02	1	Membrane;Cytosol;Secreted;Cell membrane	Hepatocellular carcinoma;Renal cell carcinoma papillary;Osteofibrous dysplasia;Deafness, autosomal recessive, 97	(Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells.;Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).	Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2.;(Microbial infection) Tyrosine phosphorylation is stimulated by L.monocytogenes InlB. Tyrosine phosphorylation is maximal 10-20 minutes after treatment with InlB and disappears by 60 minutes. The phosphorylated residues were not identified.;Ubiquitinated. Ubiquitination by CBL regulates MET endocytosis, resulting in decreasing plasma membrane receptor abundance, and in endosomal degradation and/or recycling of internalized receptors.	Belongs to the protein kinase superfamily. Tyr protein kinase family.	Cytokine-cytokine receptor interaction;Endocytosis;Axon guidance;Focal adhesion;Adherens junction;Bacterial invasion of epithelial cells;Epithelial cell signaling in Helicobacter pylori infection;Malaria;Pathways in cancer;Renal cell carcinoma;Melanoma;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Sema4D mediated inhibition of cell attachment and migration;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Negative regulation of MET activity;MET activates PTK2 signaling;MET interacts with TNS proteins;MET activates RAS signaling;MET activates RAP1 and RAC1;MET activates PI3K/AKT signaling;MET activates PTPN11;MET receptor recycling;MET Receptor Activation;MET activates STAT3;InlB-mediated entry of Listeria monocytogenes into host cell;MECP2 regulates neuronal receptors and channels	PE1	7
+NX_P08582	Melanotransferrin	738	80215	5.61	0	Cell membrane	NA	Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.	NA	Belongs to the transferrin family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational modification: synthesis of GPI-anchored proteins;Post-translational protein phosphorylation	PE1	3
+NX_P08588	Beta-1 adrenergic receptor	477	51323	9.23	7	Early endosome;Cell membrane	NA	Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.	Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.;ADRB1 is phosphorylated by GRK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Endocytosis;Gap junction;Salivary secretion;Dilated cardiomyopathy;G alpha (s) signalling events;Adrenoceptors	PE1	10
+NX_P08590	Myosin light chain 3	195	21932	5.03	0	Mitochondrion;Nucleolus	Cardiomyopathy, familial hypertrophic 8	Regulatory light chain of myosin. Does not bind calcium.	N-terminus is methylated by METTL11A/NTM1.;The N-terminus is blocked.	NA	Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Striated Muscle Contraction	PE1	3
+NX_P08603	Complement factor H	1231	139096	6.21	0	Secreted	Basal laminar drusen;Hemolytic uremic syndrome atypical 1;Complement factor H deficiency;Macular degeneration, age-related, 4	Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed:21285368, PubMed:25402769). Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop (PubMed:19503104). As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b (PubMed:18252712, PubMed:28671664). In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed (PubMed:9558116, PubMed:20008295).	NA	NA	Complement and coagulation cascades;Staphylococcus aureus infection;Regulation of Complement cascade	PE1	1
+NX_P08620	Fibroblast growth factor 4	206	22048	9.73	0	Secreted	NA	Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR1;Signaling by activated point mutants of FGFR3;FGFR4 ligand binding and activation;FGFR3c ligand binding and activation;FGFR1c ligand binding and activation;FGFR2c ligand binding and activation;FGFR3 mutant receptor activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;Phospholipase C-mediated cascade, FGFR4;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;FGFRL1 modulation of FGFR1 signaling;Signaling by FGFR3 point mutants in cancer	PE1	11
+NX_P08621	U1 small nuclear ribonucleoprotein 70 kDa	437	51557	9.94	0	Nucleoplasm;Nucleus speckle	NA	Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158).;Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.;Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.	Extensively phosphorylated on serine residues in the C-terminal region.;The N-terminus is blocked.	NA	Spliceosome;mRNA Splicing - Major Pathway	PE1	19
+NX_P08631	Tyrosine-protein kinase HCK	526	59600	6.27	0	Golgi apparatus;Secretory vesicle;Cell membrane;Focal adhesion;Podosome membrane;Nucleoplasm;Membrane;Caveola;Lysosome;Cytoplasmic vesicle;Cytosol;Nucleus;Cytoskeleton	NA	Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.	Ubiquitinated by CBL, leading to its degradation via the proteasome.;Palmitoylation at position 2 requires prior myristoylation. Palmitoylation at position 3 is required for caveolar localization of isoform 2.;Phosphorylated on several tyrosine residues. Autophosphorylated. Becomes rapidly phosphorylated upon activation of the immunoglobulin receptors FCGR1A and FCGR2A. Phosphorylation by the BCR-ABL fusion protein mediates activation of HCK. Phosphorylation at Tyr-411 increases kinase activity. Phosphorylation at Tyr-522 inhibits kinase activity. Kinase activity is not required for phosphorylation at Tyr-522, suggesting that this site is a target of other kinases.	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.	Chemokine signaling pathway;Fc gamma R-mediated phagocytosis;FCGR activation;Nef and signal transduction;Regulation of signaling by CBL;FLT3 Signaling	PE1	20
+NX_P08637	Low affinity immunoglobulin gamma Fc region receptor III-A	254	29089	8.2	1	Secreted;Cell membrane	Immunodeficiency 20	Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.	The soluble form is produced by a proteolytic cleavage.;Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.	NA	Phagosome;Osteoclast differentiation;Natural killer cell mediated cytotoxicity;Fc gamma R-mediated phagocytosis;Leishmaniasis;Staphylococcus aureus infection;Tuberculosis;Systemic lupus erythematosus;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of phospholipids in phagocytosis;FCGR activation	PE1	1
+NX_P08648	Integrin alpha-5	1049	114536	5.5	1	Cell surface;Membrane;Focal adhesion	NA	(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.;(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.;(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.;Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).	Proteolytic cleavage by PCSK5 mediates activation of the precursor.	Belongs to the integrin alpha chain family.	Phagosome;Focal adhesion;ECM-receptor interaction;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Shigellosis;Pertussis;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Signal transduction by L1;Integrin cell surface interactions;Cell surface interactions at the vascular wall;Elastic fibre formation;Fibronectin matrix formation;RUNX2 regulates genes involved in cell migration	PE1	12
+NX_P08651	Nuclear factor 1 C-type	508	55675	8.62	0	Nucleoplasm;Nucleolus;Nucleus	NA	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	NA	Belongs to the CTF/NF-I family.	RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation	PE1	19
+NX_P08670	Vimentin	466	53652	5.06	0	Golgi apparatus;Cytoplasm;Cell membrane;Nucleus matrix;Cytoskeleton	Cataract 30, multiple types	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.;Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.	S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.;O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.;Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm (PubMed:21465480). Phosphorylated by STK33 (PubMed:18811945). Phosphorylated on tyrosine residues by SRMS (PubMed:29496907).;VIM is phosphorylated by MAPK3;VIM is phosphorylated by STK33 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);VIM is phosphorylated by PKN1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the intermediate filament family.	Caspase-mediated cleavage of cytoskeletal proteins;Striated Muscle Contraction;Interleukin-4 and Interleukin-13 signaling	PE1	10
+NX_P08684	Cytochrome P450 3A4	503	57343	8.27	1	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15373842, PubMed:15764715, PubMed:20702771, PubMed:19965576, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:2732228, PubMed:14559847, PubMed:12865317, PubMed:15373842, PubMed:15764715, PubMed:21576599, PubMed:21490593). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:14559847, PubMed:12865317). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:2732228, PubMed:15373842, PubMed:15764715, PubMed:22773874). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:2732228, PubMed:15373842, PubMed:15764715). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357).	Polyubiquitinated in the presence of AMFR and UBE2G1 and also STUB1/CHIP and UBE2D1 (in vitro).	Belongs to the cytochrome P450 family.	Steroid hormone biosynthesis.;Cofactor metabolism; retinol metabolism.;Steroid metabolism; cholesterol metabolism.;Lipid metabolism; fatty acid metabolism.;Steroid hormone biosynthesis;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Bile secretion;Xenobiotics;Aflatoxin activation and detoxification;Biosynthesis of maresin-like SPMs	PE1	7
+NX_P08686	Steroid 21-hydroxylase	494	55887	7.71	0	Microsome membrane;Endoplasmic reticulum membrane	Adrenal hyperplasia 3	Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids (PubMed:22014889).	NA	Belongs to the cytochrome P450 family.	Steroid hormone biosynthesis;Metabolic pathways;Endogenous sterols;Glucocorticoid biosynthesis;Mineralocorticoid biosynthesis;Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	PE1	6
+NX_P08697	Alpha-2-antiplasmin	491	54566	5.87	0	Secreted	Alpha-2-plasmin inhibitor deficiency	Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.	Proteolytically cleaved at Pro-39 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin.	Belongs to the serpin family.	Complement and coagulation cascades;Platelet degranulation;Dissolution of Fibrin Clot	PE1	17
+NX_P08700	Interleukin-3	152	17233	8.69	0	Secreted	NA	Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.;This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.	NA	Belongs to the IL-3 family.	Cytokine-cytokine receptor interaction;Apoptosis;Jak-STAT signaling pathway;Hematopoietic cell lineage;Fc epsilon RI signaling pathway;Asthma;RAF/MAP kinase cascade;Interleukin receptor SHC signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling;RUNX1 regulates transcription of genes involved in interleukin signaling	PE1	5
+NX_P08708	40S ribosomal protein S17	135	15550	9.85	0	Cytoplasm;Nucleolus;Endoplasmic reticulum;Cytosol;Nucleus	Diamond-Blackfan anemia 4	NA	NA	Belongs to the eukaryotic ribosomal protein eS17 family.	Ribosome;Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	15
+NX_P08709	Coagulation factor VII	466	51594	6.92	0	Mitochondrion;Secreted	Factor VII deficiency	Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.	Can be either O-glucosylated or O-xylosylated at Ser-112 by POGLUT1 in vitro.;The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.;O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines.;The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.	Belongs to the peptidase S1 family.	Complement and coagulation cascades;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Extrinsic Pathway of Fibrin Clot Formation;Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins	PE1	13
+NX_P08727	Keratin, type I cytoskeletal 19	400	44106	5.05	0	Cytoskeleton	NA	Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_P08729	Keratin, type II cytoskeletal 7	469	51386	5.4	0	Cytoplasm;Cytoskeleton	NA	Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).	Arg-20 is dimethylated, probably to asymmetric dimethylarginine.	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_P08754	Guanine nucleotide-binding protein G(i) subunit alpha	354	40532	5.5	0	Membrane;Cytoplasm;Centrosome;Cell membrane	Auriculocondylar syndrome 1	Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935).	(Microbial infection) Deamidated at Gln-204 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.	Belongs to the G-alpha family. G(i/o/t/z) subfamily.	Chemokine signaling pathway;Axon guidance;Tight junction;Gap junction;Leukocyte transendothelial migration;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Long-term depression;Progesterone-mediated oocyte maturation;Melanogenesis;Gastric acid secretion;Pertussis;Chagas disease (American trypanosomiasis);Toxoplasmosis;G alpha (i) signalling events;G alpha (s) signalling events;G-protein activation;ADP signalling through P2Y purinoceptor 12;G alpha (z) signalling events;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling	PE1	1
+NX_P08758	Annexin A5	320	35937	4.94	0	Cytoplasm;Nucleus;Nucleus membrane	Pregnancy loss, recurrent, 3	This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.	S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.	Belongs to the annexin family.	Platelet degranulation	PE1	4
+NX_P08779	Keratin, type I cytoskeletal 16	473	51268	4.98	0	NA	Pachyonychia congenita 1;Keratoderma, palmoplantar, non-epidermolytic, focal 1	Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_P08833	Insulin-like growth factor-binding protein 1	259	27904	5.11	0	Golgi apparatus;Secreted	NA	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.	Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.	NA	ATF4 activates genes in response to endoplasmic reticulum stress;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	7
+NX_P08842	Steryl-sulfatase	583	65492	7.6	2	Endoplasmic reticulum membrane;Microneme membrane	Ichthyosis, X-linked	Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Steroid hormone biosynthesis;Glycosphingolipid metabolism;The activation of arylsulfatases	PE1	X
+NX_P08861	Chymotrypsin-like elastase family member 3B	270	29263	5.85	0	NA	NA	Efficient protease with alanine specificity but only little elastolytic activity.	NA	Belongs to the peptidase S1 family. Elastase subfamily.	Pancreatic secretion;Protein digestion and absorption	PE1	1
+NX_P08865	40S ribosomal protein SA	295	32854	4.79	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	Asplenia, isolated congenital	(Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus.;(Microbial infection) Acts as a receptor for the pathogenic prion protein.;Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.;(Microbial infection) Acts as a receptor for the Sindbis virus.;(Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9.;(Microbial infection) Acts as a receptor for the Dengue virus.;(Microbial infection) Acts as a receptor for bacteria.	Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association (PubMed:9581863).;Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.	Belongs to the universal ribosomal protein uS2 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	3
+NX_P08887	Interleukin-6 receptor subunit alpha	468	51548	8.56	1	Basolateral cell membrane;Secreted	NA	Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.;Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.	A short soluble form may also be released from the membrane by proteolysis.	Belongs to the type I cytokine receptor family. Type 3 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;MAPK3 (ERK1) activation;Interleukin-6 signaling;MAPK1 (ERK2) activation;Interleukin-4 and Interleukin-13 signaling;Transcriptional regulation of granulopoiesis	PE1	1
+NX_P08908	5-hydroxytryptamine receptor 1A	422	46107	9.13	7	Cell membrane	Periodic fever, menstrual cycle-dependent	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.	NA	Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Serotonin receptors	PE1	5
+NX_P08910	Monoacylglycerol lipase ABHD2	425	48315	6.24	1	Nucleoplasm;Cytosol;Cell membrane;Flagellum membrane	NA	Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (PubMed:27247428). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).	NA	Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.	NA	PE1	15
+NX_P08912	Muscarinic acetylcholine receptor M5	532	60074	9.39	7	Postsynaptic cell membrane;Cell membrane	NA	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.	NA	Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Cholinergic synapse;Regulation of actin cytoskeleton;G alpha (q) signalling events;Muscarinic acetylcholine receptors	PE1	15
+NX_P08913	Alpha-2A adrenergic receptor	450	48957	9.8	7	Cell membrane	NA	Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.	NA	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (z) signalling events;Adrenoceptors;Adrenaline signalling through Alpha-2 adrenergic receptor;Surfactant metabolism	PE1	10
+NX_P08922	Proto-oncogene tyrosine-protein kinase ROS	2347	263915	5.76	1	Cytoplasmic vesicle;Cell membrane	NA	Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.	Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation (By similarity). Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade (By similarity). Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11.;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	NA	PE1	6
+NX_P08949	Neuromedin-B	121	13252	11.87	0	Cell membrane;Nucleoplasm;Secreted;Cytoplasmic vesicle	NA	Stimulates smooth muscle contraction in a manner similar to that of bombesin.	NA	Belongs to the bombesin/neuromedin-B/ranatensin family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	15
+NX_P08962	CD63 antigen	238	25637	8.14	4	Extracellular exosome;Cytoplasm;Cell membrane;Multivesicular body;Lysosome membrane;Late endosome membrane;Cell surface;Melanosome;Lysosome;Cytoplasmic vesicle;Nucleus	NA	Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.	Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).	Belongs to the tetraspanin (TM4SF) family.	Lysosome;Platelet degranulation;Neutrophil degranulation	PE1	12
+NX_P08F94	Fibrocystin	4074	446702	6.12	1	Cytoplasm;Cell membrane;Cilium;Cilium basal body;Centromere;Spindle	Polycystic kidney disease 4, with or without polycystic liver disease	May be required for correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly. May be a receptor protein that acts in collecting-duct and biliary differentiation.	NA	NA	NA	PE1	6
+NX_P09001	39S ribosomal protein L3, mitochondrial	348	38633	9.52	0	Mitochondrion	Combined oxidative phosphorylation deficiency 9	NA	NA	Belongs to the universal ribosomal protein uL3 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	3
+NX_P09012	U1 small nuclear ribonucleoprotein A	282	31280	9.83	0	Nucleoplasm;Nucleus	NA	Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.	NA	Belongs to the RRM U1 A/B'' family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	19
+NX_P09016	Homeobox protein Hox-D4	255	27885	9.44	0	Nucleoplasm;Cell junction;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family. Deformed subfamily.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	2
+NX_P09017	Homeobox protein Hox-C4	264	29811	9.24	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family. Deformed subfamily.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	12
+NX_P09038	Fibroblast growth factor 2	288	30770	11.18	0	Nucleoplasm;Secreted;Nucleus	NA	Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677).	Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.;Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;FGFR2b ligand binding and activation;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR1;Signaling by activated point mutants of FGFR3;FGFR4 ligand binding and activation;FGFR3c ligand binding and activation;FGFR1c ligand binding and activation;FGFR2c ligand binding and activation;FGFR3 mutant receptor activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;Phospholipase C-mediated cascade, FGFR4;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;Syndecan interactions;Non-integrin membrane-ECM interactions;FGFR1b ligand binding and activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;FGFRL1 modulation of FGFR1 signaling;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR2 IIIa TM;Interleukin-4 and Interleukin-13 signaling	PE1	4
+NX_P09067	Homeobox protein Hox-B5	269	29434	9.1	0	Nucleoplasm;Nucleolus;Cytosol;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	NA	PE1	17
+NX_P09086	POU domain, class 2, transcription factor 2	479	51209	8.6	0	Cytoplasmic vesicle;Nucleoplasm;Cytoplasm;Nucleus	NA	Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR.;Activates the U2 small nuclear RNA (snRNA) promoter.	NA	Belongs to the POU transcription factor family. Class-2 subfamily.	RNA polymerase II transcribes snRNA genes	PE1	19
+NX_P09093	Chymotrypsin-like elastase family member 3A	270	29489	6.43	0	NA	NA	Efficient protease with alanine specificity but only little elastolytic activity.	NA	Belongs to the peptidase S1 family. Elastase subfamily.	Pancreatic secretion;Protein digestion and absorption	PE1	1
+NX_P09104	Gamma-enolase	434	47269	4.91	0	Cytoplasm;Cell membrane	NA	Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).	NA	Belongs to the enolase family.	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.;Glycolysis / Gluconeogenesis;Metabolic pathways;RNA degradation;Glycolysis;Gluconeogenesis	PE1	12
+NX_P09105	Hemoglobin subunit theta-1	142	15508	7.09	0	Lipid droplet	NA	NA	NA	Belongs to the globin family.	NA	PE1	16
+NX_P09110	3-ketoacyl-CoA thiolase, peroxisomal	424	44292	8.76	0	Peroxisome	NA	NA	NA	Belongs to the thiolase-like superfamily. Thiolase family.	Lipid metabolism; fatty acid metabolism.;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Biosynthesis of unsaturated fatty acids;Metabolic pathways;PPAR signaling pathway;Peroxisome;alpha-linolenic acid (ALA) metabolism;Beta-oxidation of very long chain fatty acids;Neutrophil degranulation;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins	PE1	3
+NX_P09131	P3 protein	477	50333	7.65	8	Membrane;Endoplasmic reticulum;Cytoskeleton	NA	The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.	NA	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.	NA	PE1	X
+NX_P09132	Signal recognition particle 19 kDa protein	144	16156	9.87	0	Cytoplasm	NA	Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.	NA	Belongs to the SRP19 family.	Protein export;SRP-dependent cotranslational protein targeting to membrane	PE1	5
+NX_P09172	Dopamine beta-hydroxylase	617	69065	5.97	1	Chromaffin granule membrane;Secretory vesicle lumen;Secreted;Endoplasmic reticulum;Secretory vesicle membrane;Chromaffin granule lumen;Cytoplasmic vesicle	Orthostatic hypotension 1	Conversion of dopamine to noradrenaline.	N-glycosylated.;Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.	Belongs to the copper type II ascorbate-dependent monooxygenase family.	Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.;Tyrosine metabolism;Metabolic pathways;Catecholamine biosynthesis	PE1	9
+NX_P09210	Glutathione S-transferase A2	222	25664	8.51	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.	NA	Belongs to the GST superfamily. Alpha family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	6
+NX_P09211	Glutathione S-transferase P	210	23356	5.43	0	Cytoplasm;Cytosol;Mitochondrion;Nucleus	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.	NA	Belongs to the GST superfamily. Pi family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Pathways in cancer;Prostate cancer;Detoxification of Reactive Oxygen Species;Glutathione conjugation;Neutrophil degranulation	PE1	11
+NX_P09228	Cystatin-SA	141	16445	4.85	0	Secreted	NA	Thiol protease inhibitor.	NA	Belongs to the cystatin family.	Salivary secretion	PE1	20
+NX_P09234	U1 small nuclear ribonucleoprotein C	159	17394	9.72	0	Nucleus	NA	Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	NA	Belongs to the U1 small nuclear ribonucleoprotein C family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	6
+NX_P09237	Matrilysin	267	29677	7.73	0	Cytoplasmic vesicle;Nucleoplasm;Extracellular matrix	NA	Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.	NA	Belongs to the peptidase M10A family.	Wnt signaling pathway;Degradation of the extracellular matrix;Collagen degradation;Assembly of collagen fibrils and other multimeric structures;Activation of Matrix Metalloproteinases;Extra-nuclear estrogen signaling	PE1	11
+NX_P09238	Stromelysin-2	476	54151	5.49	0	Cytosol;Extracellular matrix;Cell membrane	NA	Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.	NA	Belongs to the peptidase M10A family.	Degradation of the extracellular matrix;Collagen degradation;Activation of Matrix Metalloproteinases	PE1	11
+NX_P09326	CD48 antigen	243	27683	8.34	0	Cytosol;Nucleolus;Cell membrane	NA	Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.	NA	NA	Natural killer cell mediated cytotoxicity;Cell surface interactions at the vascular wall	PE1	1
+NX_P09327	Villin-1	827	92695	5.99	0	Filopodium tip;Cell membrane;Lamellipodium;Filopodium;Ruffle;Microvillus;Cytoskeleton	NA	Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.	Tyrosine phosphorylation is induced by epidermal growth factor (EGF) and stimulates cell migration (By similarity). Phosphorylated on tyrosine residues by SRC. The unphosphorylated form increases the initial rate of actin-nucleating activity, whereas the tyrosine-phosphorylated form inhibits actin-nucleating activity, enhances actin-bundling activity and enhances actin-severing activity by reducing high Ca(2+) requirements. The tyrosine-phosphorylated form does not regulate actin-capping activity. Tyrosine phosphorylation is essential for cell migration: tyrosine phosphorylation sites in the N-terminus half regulate actin reorganization and cell morphology, whereas tyrosine phosphorylation sites in the C-terminus half regulate cell migration via interaction with PLCG1.;VIL1 is phosphorylated by YES1 (Phosphotyrosine:PTM-0255);VIL1 is phosphorylated by FYN (Phosphotyrosine:PTM-0255);VIL1 is phosphorylated by JAK3	Belongs to the villin/gelsolin family.	NA	PE1	2
+NX_P09341	Growth-regulated alpha protein	107	11301	10.46	0	Secreted	NA	Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.	N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;NOD-like receptor signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Salmonella infection;Legionellosis;Amoebiasis;Rheumatoid arthritis;G alpha (i) signalling events;Chemokine receptors bind chemokines;Neutrophil degranulation;Interleukin-10 signaling	PE1	4
+NX_P09382	Galectin-1	135	14716	5.33	0	Cytoplasm;Extracellular matrix;Nucleoplasm;Cytosol;Nucleus	NA	Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.	NA	NA	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	22
+NX_P09417	Dihydropteridine reductase	244	25790	6.9	0	Mitochondrion	Hyperphenylalaninemia, BH4-deficient, C	The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Folate biosynthesis;Metabolic pathways;Phenylalanine metabolism	PE1	4
+NX_P09429	High mobility group protein B1	215	24894	5.62	0	Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Cell membrane;Secreted;Chromosome;Nucleoplasm;Endosome;Nucleus	NA	Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101).;In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity).;In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity).;Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19446504, PubMed:19360789). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity).	Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS (By similarity).;Acetylated on multiple sites upon stimulation with LPS (PubMed:22801494). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion (By similarity). Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity (By similarity).;Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion (PubMed:17114460).;In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance (PubMed:24474694). Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and proinflammatory activities (By similarity).;Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).	Belongs to the HMGB family.	Base excision repair;Advanced glycosylation endproduct receptor signaling;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;Regulation of TLR by endogenous ligand;Neutrophil degranulation;Apoptosis induced DNA fragmentation	PE1	13
+NX_P09430	Spermatid nuclear transition protein 1	55	6424	12.09	0	Nucleus;Chromosome	NA	Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.	NA	Belongs to the nuclear transition protein 1 family.	NA	PE1	2
+NX_P09455	Retinol-binding protein 1	135	15850	4.99	0	Cytoplasm;Nucleoplasm;Lipid droplet;Cytosol	NA	Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665496).	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	The canonical retinoid cycle in rods (twilight vision);Retinoid metabolism and transport;Retinoid cycle disease events	PE1	3
+NX_P09466	Glycodelin	180	20624	5.36	0	Secreted	NA	Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).	Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C.	Belongs to the calycin superfamily. Lipocalin family.	NA	PE1	9
+NX_P09467	Fructose-1,6-bisphosphatase 1	338	36842	6.54	0	Mitochondrion	Fructose-1,6-bisphosphatase deficiency	Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.	NA	Belongs to the FBPase class 1 family.	Carbohydrate biosynthesis; gluconeogenesis.;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Fructose and mannose metabolism;Metabolic pathways;Insulin signaling pathway;Gluconeogenesis	PE1	9
+NX_P09471	Guanine nucleotide-binding protein G(o) subunit alpha	354	40051	5.34	0	Membrane;Cell membrane	Epileptic encephalopathy, early infantile, 17;Neurodevelopmental disorder with involuntary movements	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.	NA	Belongs to the G-alpha family. G(i/o/t/z) subfamily.	Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Long-term depression;Melanogenesis;Chagas disease (American trypanosomiasis);Toxoplasmosis;G-protein activation;Ca2+ pathway;PLC beta mediated events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	16
+NX_P09486	SPARC	303	34632	4.73	0	Cytoplasmic vesicle;Basement membrane	Osteogenesis imperfecta 17	Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.	NA	Belongs to the SPARC family.	Nuclear signaling by ERBB4;Platelet degranulation;ECM proteoglycans;Scavenging by Class H Receptors	PE1	5
+NX_P09488	Glutathione S-transferase Mu 1	218	25712	6.24	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.	NA	Belongs to the GST superfamily. Mu family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation	PE1	1
+NX_P09493	Tropomyosin alpha-1 chain	284	32709	4.69	0	Cytoplasm;Cytoskeleton	Cardiomyopathy, familial hypertrophic 3;Cardiomyopathy, dilated 1Y;Left ventricular non-compaction 9	Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.	Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells.;TPM1 is phosphorylated by PRKCZ (Phosphoserine:PTM-0253)	Belongs to the tropomyosin family.	Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Striated Muscle Contraction;Smooth Muscle Contraction	PE1	15
+NX_P09496	Clathrin light chain A	248	27077	4.43	0	Coated pit;Cytoplasmic vesicle membrane;Endosome;Lysosome;Cytoplasmic vesicle;Spindle	NA	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).	NA	Belongs to the clathrin light chain family.	Lysosome;Endocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Huntington's disease;Bacterial invasion of epithelial cells;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Golgi Associated Vesicle Biogenesis;Retrograde neurotrophin signalling;Lysosome Vesicle Biogenesis;Recycling pathway of L1;Gap junction degradation;WNT5A-dependent internalization of FZD4;Formation of annular gap junctions;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;Entry of Influenza Virion into Host Cell via Endocytosis;LDL clearance	PE1	9
+NX_P09497	Clathrin light chain B	229	25190	4.57	0	Cell membrane;Coated pit;Cytoplasmic vesicle membrane;Cytoplasmic vesicle;Cytosol	NA	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.	NA	Belongs to the clathrin light chain family.	Lysosome;Endocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Huntington's disease;Bacterial invasion of epithelial cells;EPH-ephrin mediated repulsion of cells;Lysosome Vesicle Biogenesis;Gap junction degradation;WNT5A-dependent internalization of FZD4;Formation of annular gap junctions;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	5
+NX_P09525	Annexin A4	319	35883	5.84	0	Cytosol	NA	Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.	NA	Belongs to the annexin family.	NA	PE1	2
+NX_P09529	Inhibin beta B chain	407	45122	8.35	0	Secreted	NA	Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.	NA	Belongs to the TGF-beta family.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Glycoprotein hormones;Signaling by Activin;Antagonism of Activin by Follistatin	PE1	2
+NX_P09543	2',3'-cyclic-nucleotide 3'-phosphodiesterase	421	47579	9.17	0	Membrane;Nucleoplasm;Cytosol;Melanosome	NA	May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.	NA	Belongs to the 2H phosphoesterase superfamily. CNPase family.	NA	PE1	17
+NX_P09544	Protein Wnt-2	360	40418	9.06	0	Cytoplasmic vesicle;Extracellular matrix;Secreted	NA	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors)	PE1	7
+NX_P09564	T-cell antigen CD7	240	25409	6.87	1	Membrane	NA	Not yet known.	NA	NA	Hematopoietic cell lineage	PE1	17
+NX_P09565	Putative insulin-like growth factor 2-associated protein	113	12087	9.65	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_P09601	Heme oxygenase 1	288	32819	7.89	0	Golgi apparatus;Endoplasmic reticulum membrane;Microsome;Cell membrane	Heme oxygenase 1 deficiency	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.	NA	Belongs to the heme oxygenase family.	Porphyrin and chlorophyll metabolism;Mineral absorption;Iron uptake and transport;Heme degradation;Interleukin-4 and Interleukin-13 signaling;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	22
+NX_P09603	Macrophage colony-stimulating factor 1	554	60179	5.16	1	Extracellular space;Nucleus;Cell membrane	NA	Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.	Is only N-glycosylated.;Is N- and O-glycosylated.;N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans.	NA	Cytokine-cytokine receptor interaction;Osteoclast differentiation;Hematopoietic cell lineage;Rheumatoid arthritis;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Interleukin-10 signaling;Post-translational protein phosphorylation;Other interleukin signaling	PE1	1
+NX_P09619	Platelet-derived growth factor receptor beta	1106	123968	4.88	1	Golgi apparatus;Cytoplasmic vesicle;Lysosome lumen;Cell membrane	Basal ganglia calcification, idiopathic, 4;Leukemia, juvenile myelomonocytic;Kosaki overgrowth syndrome;Myofibromatosis, infantile 1;Myeloproliferative disorder chronic with eosinophilia;Premature aging syndrome, Penttinen type;Leukemia, acute myelogenous	Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.	N-glycosylated.;Ubiquitinated. After autophosphorylation, the receptor is polyubiquitinated, leading to its degradation.;Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. One subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-579, and to a lesser degree, at Tyr-581, is important for interaction with SRC family kinases. Phosphorylation at Tyr-740 and Tyr-751 is important for interaction with PIK3R1. Phosphorylation at Tyr-751 is important for interaction with NCK1. Phosphorylation at Tyr-771 and Tyr-857 is important for interaction with RASA1/GAP. Phosphorylation at Tyr-857 is important for efficient phosphorylation of PLCG1 and PTPN11, resulting in increased phosphorylation of AKT1, MAPK1/ERK2 and/or MAPK3/ERK1, PDCD6IP/ALIX and STAM, and in increased cell proliferation. Phosphorylation at Tyr-1009 is important for interaction with PTPN11. Phosphorylation at Tyr-1009 and Tyr-1021 is important for interaction with PLCG1. Phosphorylation at Tyr-1021 is important for interaction with CBL; PLCG1 and CBL compete for the same binding site. Dephosphorylated by PTPRJ at Tyr-751, Tyr-857, Tyr-1009 and Tyr-1021. Dephosphorylated by PTPN2 at Tyr-579 and Tyr-1021.;PDGFRB is phosphorylated by GRK5 (Phosphoserine,Phosphotyrosine:PTM-0253,PTM-0255);PDGFRB is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255);PDGFRB is phosphorylated by ABL2 (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	MAPK signaling pathway;Calcium signaling pathway;Cytokine-cytokine receptor interaction;Focal adhesion;Gap junction;Regulation of actin cytoskeleton;HTLV-I infection;Pathways in cancer;Glioma;Prostate cancer;Melanoma;RAF/MAP kinase cascade;Signaling by PDGF;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Downstream signal transduction;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	5
+NX_P09622	Dihydrolipoyl dehydrogenase, mitochondrial	509	54177	7.95	0	Mitochondrion;Mitochondrion matrix;Flagellum;Nucleus;Acrosome	Dihydrolipoamide dehydrogenase deficiency	Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).	Tyrosine phosphorylated.	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Glycolysis / Gluconeogenesis;Citrate cycle (TCA cycle);Glycine, serine and threonine metabolism;Valine, leucine and isoleucine degradation;Pyruvate metabolism;Metabolic pathways;Branched-chain amino acid catabolism;Citric acid cycle (TCA cycle);Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex;Pyruvate metabolism;Lysine catabolism;Glyoxylate metabolism and glycine degradation;Glycine degradation	PE1	7
+NX_P09629	Homeobox protein Hox-B7	217	24015	8.83	0	Nucleoplasm;Cytosol;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	NA	PE1	17
+NX_P09630	Homeobox protein Hox-C6	235	26915	9.18	0	Nucleoplasm;Cytosol;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	NA	PE1	12
+NX_P09651	Heterogeneous nuclear ribonucleoprotein A1	372	38747	9.17	0	Cytoplasm;Nucleus	Amyotrophic lateral sclerosis 20;Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3	Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233).;(Microbial infection) May play a role in HCV RNA replication.	Sumoylated.;Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine.;HNRNPA1 is phosphorylated by MKNK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Spliceosome;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;FGFR2 alternative splicing	PE1	12
+NX_P09661	U2 small nuclear ribonucleoprotein A'	255	28416	8.71	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:27035939). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128, PubMed:27035939).	NA	Belongs to the U2 small nuclear ribonucleoprotein A family.	Spliceosome;mRNA Splicing - Major Pathway;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	15
+NX_P09668	Pro-cathepsin H	335	37394	8.35	0	Cytoplasmic vesicle;Cytosol;Lysosome	NA	Important for the overall degradation of proteins in lysosomes.	NA	Belongs to the peptidase C1 family.	Lysosome;MHC class II antigen presentation;Surfactant metabolism;Neutrophil degranulation	PE1	15
+NX_P09669	Cytochrome c oxidase subunit 6C	75	8781	10.38	1	Mitochondrion inner membrane;Mitochondrion	NA	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase subunit 6c family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	8
+NX_P09681	Gastric inhibitory polypeptide	153	17108	7.8	0	Secreted	NA	Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.	NA	Belongs to the glucagon family.	G alpha (s) signalling events;Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);Glucagon-type ligand receptors	PE1	17
+NX_P09683	Secretin	121	13016	11.27	0	Secreted	NA	Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973). Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells (PubMed:25332973). Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (By similarity). Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (Probable). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (By similarity). Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity).	NA	Belongs to the glucagon family.	G alpha (s) signalling events;Glucagon-type ligand receptors	PE1	11
+NX_P09693	T-cell surface glycoprotein CD3 gamma chain	182	20469	8.6	1	Cytosol;Cell membrane	Immunodeficiency 17	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.	Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8 (PubMed:2470098). Phosphorylated also by PKC; leading to the TCR complex down-regulation (PubMed:8187769).;Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.	NA	Hematopoietic cell lineage;T cell receptor signaling pathway;Chagas disease (American trypanosomiasis);Measles;HTLV-I infection;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling;Role of phospholipids in phagocytosis;FCGR activation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	11
+NX_P09758	Tumor-associated calcium signal transducer 2	323	35709	9.14	1	Membrane;Cytoplasmic vesicle;Nucleolus;Cell membrane	Corneal dystrophy, gelatinous drop-like	May function as a growth factor receptor.	The N-terminus is blocked.	Belongs to the EPCAM family.	NA	PE1	1
+NX_P09769	Tyrosine-protein kinase Fgr	529	59479	5.41	0	Cell membrane;Mitochondrion intermembrane space;Ruffle membrane;Cytosol;Mitochondrion inner membrane;Cytoskeleton	NA	Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.	Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation.;Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.	Chemokine signaling pathway;FCGR activation;Platelet sensitization by LDL;Neutrophil degranulation	PE1	1
+NX_P09848	Lactase-phlorizin hydrolase	1927	218587	5.9	1	Apical cell membrane	Congenital lactase deficiency	LPH splits lactose in the small intestine.	NA	Belongs to the glycosyl hydrolase 1 family.	Galactose metabolism;Metabolic pathways;Carbohydrate digestion and absorption;Digestion of dietary carbohydrate;Intestinal saccharidase deficiencies	PE1	2
+NX_P09871	Complement C1s subcomponent	688	76684	4.86	0	Nucleoplasm;Cytosol	Complement component C1s deficiency;Ehlers-Danlos syndrome, periodontal type, 2	C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Pertussis;Staphylococcus aureus infection;Systemic lupus erythematosus;Regulation of Complement cascade;Initial triggering of complement;Classical antibody-mediated complement activation	PE1	12
+NX_P09874	Poly [ADP-ribose] polymerase 1	1014	113084	8.99	0	Nucleoplasm;Nucleus;Nucleolus;Chromosome	NA	Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:25043379, PubMed:26344098). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:7852410, PubMed:9315851, PubMed:19764761, PubMed:25043379). Mediates the poly(ADP-ribosyl)ation of a number of proteins, including itself, APLF and CHFR (PubMed:17396150, PubMed:19764761). Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). Probably also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:30257210). Catalyzes the poly-ADP-ribosylation of histones in a HPF1-dependent manner (PubMed:27067600). Involved in the base excision repair (BER) pathway by catalyzing the poly-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). Acts as a regulator of transcription: positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150 (PubMed:19344625). With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (PubMed:17177976). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).	Poly-ADP-ribosylated on glutamate and aspartate residues by autocatalysis (PubMed:19764761). Poly-ADP-ribosylated by PARP2; poly-ADP-ribosylation mediates the recruitment of CHD1L to DNA damage sites (PubMed:19661379). ADP-ribosylated on serine by autocatalysis; serine ADP-ribosylation takes place following interaction with HPF1 (PubMed:28190768).;Phosphorylated by PRKDC and TXK.;S-nitrosylated, leading to inhibit transcription regulation activity.;PARP1 is phosphorylated by TXK (Phosphotyrosine:PTM-0255)	NA	Base excision repair;SUMOylation of DNA damage response and repair proteins;Downregulation of SMAD2/3:SMAD4 transcriptional activity;POLB-Dependent Long Patch Base Excision Repair;HDR through MMEJ (alt-NHEJ);DNA Damage Recognition in GG-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER	PE1	1
+NX_P09884	DNA polymerase alpha catalytic subunit	1462	165913	5.61	0	Nucleoplasm;Cytosol;Nucleus	Pigmentary disorder, reticulate, with systemic manifestations, X-linked	Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227).	A 165 kDa form is probably produced by proteolytic cleavage at Lys-124.	Belongs to the DNA polymerase type-B family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Activation of the pre-replicative complex;G1/S-Specific Transcription;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;Telomere C-strand synthesis initiation;DNA replication initiation	PE1	X
+NX_P09912	Interferon alpha-inducible protein 6	130	12927	5.27	4	Mitochondrion inner membrane;Mitochondrion	NA	Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells (PubMed:25757571).	Glycosylated.	Belongs to the IFI6/IFI27 family.	Interferon alpha/beta signaling	PE1	1
+NX_P09913	Interferon-induced protein with tetratricopeptide repeats 2	472	54632	6.32	0	Endoplasmic reticulum;Cytoplasmic vesicle;Cytoplasm	NA	IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.	NA	Belongs to the IFIT family.	Interferon alpha/beta signaling	PE1	10
+NX_P09914	Interferon-induced protein with tetratricopeptide repeats 1	478	55360	6.75	0	Cytoplasm;Cytosol	NA	Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.	ISGylated.;Phosphorylated.	Belongs to the IFIT family.	Hepatitis C;Herpes simplex infection;ISG15 antiviral mechanism;Interferon alpha/beta signaling	PE1	10
+NX_P09917	Arachidonate 5-lipoxygenase	674	77983	5.51	0	Nucleoplasm;Nucleus matrix;Cytoplasm;Nucleus membrane	NA	Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.	Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.	Belongs to the lipoxygenase family.	Lipid metabolism; leukotriene A4 biosynthesis.;Arachidonic acid metabolism;Metabolic pathways;Toxoplasmosis;Synthesis of Leukotrienes (LT) and Eoxins (EX);Synthesis of Lipoxins (LX);Synthesis of 5-eicosatetraenoic acids;Neutrophil degranulation;Interleukin-4 and Interleukin-13 signaling;Interleukin-18 signaling;Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives;Biosynthesis of maresins;Biosynthesis of D-series resolvins;Biosynthesis of E-series 18(S)-resolvins;Biosynthesis of aspirin-triggered D-series resolvins;Biosynthesis of E-series 18(R)-resolvins;Biosynthesis of DPAn-3-derived protectins and resolvins;Biosynthesis of DPAn-3-derived maresins;Biosynthesis of DPAn-3-derived 13-series resolvins	PE1	10
+NX_P09919	Granulocyte colony-stimulating factor	207	22293	5.61	0	Secreted	NA	Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.	O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).	Belongs to the IL-6 superfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Malaria;Interleukin-10 signaling;Other interleukin signaling	PE1	17
+NX_P09923	Intestinal-type alkaline phosphatase	528	56812	5.53	0	Cell membrane	NA	NA	NA	Belongs to the alkaline phosphatase family.	Folate biosynthesis;Metabolic pathways;Synthesis of PA;Digestion;Post-translational modification: synthesis of GPI-anchored proteins	PE1	2
+NX_P09936	Ubiquitin carboxyl-terminal hydrolase isozyme L1	223	24824	5.33	0	Cytoplasm;Nucleoplasm;Endoplasmic reticulum membrane;Cytosol	Parkinson disease 5;Spastic paraplegia 79, autosomal recessive	Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (PubMed:9774100, PubMed:8639624, PubMed:12408865, PubMed:23359680). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (PubMed:12408865).	O-glycosylated.	Belongs to the peptidase C12 family.	Parkinson's disease;UCH proteinases	PE1	4
+NX_P09958	Furin	794	86678	6.01	1	Golgi apparatus;Endosome membrane;Cell membrane;trans-Golgi network membrane;Secreted;Nucleoplasm	NA	(Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP.;(Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin.;(Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins.;Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999).	Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms.;The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.	Belongs to the peptidase S8 family. Furin subfamily.	Influenza A;Signaling by PDGF;Uptake and function of anthrax toxins;Amyloid fiber formation;Collagen degradation;Pre-NOTCH Processing in Golgi;Activation of Matrix Metalloproteinases;Elastic fibre formation;TGF-beta receptor signaling activates SMADs;Signaling by NODAL;NGF processing;Removal of aminoterminal propeptides from gamma-carboxylated proteins;Synthesis and processing of ENV and VPU;Formation of the cornified envelope;Assembly of active LPL and LIPC lipase complexes	PE1	15
+NX_P09960	Leukotriene A-4 hydrolase	611	69285	5.8	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.	Phosphorylation at Ser-416 inhibits enzymatic activity.	Belongs to the peptidase M1 family.	Lipid metabolism; leukotriene B4 biosynthesis.;Arachidonic acid metabolism;Metabolic pathways;Synthesis of Leukotrienes (LT) and Eoxins (EX);Neutrophil degranulation;Biosynthesis of D-series resolvins;Biosynthesis of E-series 18(S)-resolvins;Biosynthesis of protectins;Biosynthesis of aspirin-triggered D-series resolvins;Biosynthesis of E-series 18(R)-resolvins	PE1	12
+NX_P09972	Fructose-bisphosphate aldolase C	364	39456	6.41	0	Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleolus	NA	NA	NA	Belongs to the class I fructose-bisphosphate aldolase family.	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Fructose and mannose metabolism;Metabolic pathways;Glycolysis;Gluconeogenesis;Neutrophil degranulation	PE1	17
+NX_P0C024	Peroxisomal coenzyme A diphosphatase NUDT7	238	26942	6.55	0	Golgi apparatus;Peroxisome;Nucleoplasm	NA	Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).	NA	Belongs to the Nudix hydrolase family. PCD1 subfamily.	Peroxisomal lipid metabolism;Peroxisomal protein import	PE1	16
+NX_P0C025	Nucleoside diphosphate-linked moiety X motif 17	328	35923	6.2	0	Cytosol;Centrosome	NA	Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.	NA	Belongs to the Nudix hydrolase family.	NA	PE1	1
+NX_P0C091	FRAS1-related extracellular matrix protein 3	2139	238179	5.14	0	Extracellular matrix	NA	Extracellular matrix protein which may play a role in cell adhesion.	NA	Belongs to the FRAS1 family.	NA	PE2	4
+NX_P0C0E4	Ras-related protein Rab-40A-like	278	31239	9.64	0	Membrane;Cytoplasm;Mitochondrion	Mental retardation, X-linked, syndromic, Martin-Probst type	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the small GTPase superfamily. Rab family.	Protein modification; protein ubiquitination.	PE1	X
+NX_P0C0L4	Complement C4-A	1744	192785	6.66	0	Axon;Dendrite;Secreted;Synapse	Systemic lupus erythematosus;Complement component 4A deficiency	Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.;Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.	N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.;Prior to secretion, the single-chain precursor is enzymatically cleaved to yield non-identical chains alpha, beta and gamma. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase. The proteolytic cleavages often are incomplete so that many structural forms can be found in plasma.	NA	Complement and coagulation cascades;Pertussis;Staphylococcus aureus infection;Systemic lupus erythematosus;Regulation of Complement cascade;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Initial triggering of complement;Activation of C3 and C5;Post-translational protein phosphorylation	PE1	6
+NX_P0C0L5	Complement C4-B	1744	192751	6.89	0	Axon;Dendrite;Secreted;Synapse	Complement component 4B deficiency;Systemic lupus erythematosus	Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.;Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.	Prior to secretion, the single-chain precursor is enzymatically cleaved to yield non-identical chains alpha, beta and gamma. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase. The proteolytic cleavages often are incomplete so that many structural forms can be found in plasma.	NA	Complement and coagulation cascades;Pertussis;Staphylococcus aureus infection;Systemic lupus erythematosus;Regulation of Complement cascade;Initial triggering of complement;Activation of C3 and C5	PE1	6
+NX_P0C0P6	Neuropeptide S	89	10103	10.3	0	Secreted	NA	Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).	NA	NA	Peptide ligand-binding receptors;G alpha (q) signalling events;G alpha (s) signalling events	PE2	10
+NX_P0C0S5	Histone H2A.Z	128	13553	10.58	0	Nucleoplasm;Nucleus;Chromosome	NA	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.	Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site.;Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity).;Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.;Not phosphorylated.	Belongs to the histone H2A family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;RMTs methylate histone arginines;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	4
+NX_P0C0S8	Histone H2A type 1	130	14091	10.9	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).;Deiminated on Arg-4 in granulocytes upon calcium entry.;Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.;Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.	Belongs to the histone H2A family.	Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;RMTs methylate histone arginines;HATs acetylate histones;HDACs deacetylate histones;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs	PE1	6
+NX_P0C1H6	Histone H2B type F-M	154	17001	10.08	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	NA	Belongs to the histone H2B family.	NA	PE1	X
+NX_P0C1S8	Wee1-like protein kinase 2	567	62925	6.06	0	Nucleoplasm;Nucleus	Oocyte maturation defect 5	Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).	Phosphorylated on serine residues (PubMed:29606300). Phosphorylation leads to increase its activity (By similarity).	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.	Cell cycle	PE1	7
+NX_P0C1Z6	TCF3 fusion partner	253	28278	5.19	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Appears to promote apoptosis in a p53/TP53-independent manner.;Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	NA	NA	DNA Damage Recognition in GG-NER;UCH proteinases	PE1	19
+NX_P0C221	Coiled-coil domain-containing protein 175	793	93626	6.34	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	14
+NX_P0C263	Serine/threonine-protein kinase SBK2	348	38088	5.3	0	NA	NA	NA	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.	NA	PE1	19
+NX_P0C264	Uncharacterized serine/threonine-protein kinase SBK3	359	38488	4.71	0	Mitochondrion	NA	NA	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.	NA	PE1	19
+NX_P0C2L3	Protein FAM163B	166	18190	4.86	1	Membrane;Cytosol;Nucleus;Cell membrane	NA	NA	NA	Belongs to the FAM163 family.	NA	PE1	9
+NX_P0C2S0	Cortexin-2	81	8980	4.36	1	Membrane	NA	NA	NA	Belongs to the cortexin family.	NA	PE2	15
+NX_P0C2W1	F-box/SPRY domain-containing protein 1	286	30633	8.01	0	Cytosol;Presynaptic cell membrane;Postsynaptic cell membrane	NA	Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.	NA	Belongs to the FBXO45/Fsn family.	Protein modification; protein ubiquitination.	PE1	3
+NX_P0C2W7	Cancer/testis antigen 47B	299	31319	4.11	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_P0C2Y1	Putative neuroblastoma breakpoint family member 7	421	48090	4.73	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE5	1
+NX_P0C5J1	Putative protein N-methyltransferase FAM86B2	330	36771	5.85	0	NA	NA	NA	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.	NA	PE1	8
+NX_P0C5K6	Putative tumor antigen NA88-A	33	3500	9.5	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_P0C5K7	Cancer/testis antigen 62	136	15412	9.08	0	NA	NA	NA	NA	NA	NA	PE2	15
+NX_P0C5Y4	Keratin-associated protein 1-4	121	12324	6.14	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 1 family.	Keratinization	PE2	17
+NX_P0C5Y9	Histone H2A-Bbd type 1	115	12697	10.67	0	Nucleus;Chromosome	NA	Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410). They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134).	NA	Belongs to the histone H2A family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;RMTs methylate histone arginines;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	X
+NX_P0C5Z0	Histone H2A-Bbd type 2/3	115	12713	10.67	0	Nucleus;Chromosome	NA	Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.	NA	Belongs to the histone H2A family.	Systemic lupus erythematosus;Systemic lupus erythematosus	PE1	X
+NX_P0C604	Olfactory receptor 4A8	315	35621	7.93	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_P0C617	Olfactory receptor 5AL1	328	36816	7.52	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_P0C623	Olfactory receptor 4Q2	307	34733	8.63	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	14
+NX_P0C626	Olfactory receptor 5G3	314	35647	8.86	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_P0C628	Olfactory receptor 5AC1	307	34762	9.22	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	3
+NX_P0C629	Olfactory receptor 10J4	311	34891	9.2	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	1
+NX_P0C645	Olfactory receptor 4E1	315	35737	8.58	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	14
+NX_P0C646	Olfactory receptor 52Z1	298	33382	8.97	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_P0C671	Protein BNIP5	652	71930	8.7	0	NA	NA	NA	NA	NA	NA	PE1	6
+NX_P0C672	Putative tetraspanin-19	248	28460	7.55	3	Membrane	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE5	12
+NX_P0C6A0	GATA-type zinc finger protein 1	271	29628	9.34	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function (By similarity).	NA	NA	NA	PE1	19
+NX_P0C6C1	Ankyrin repeat domain-containing protein 34C	535	58256	9.15	0	Mitochondrion	NA	NA	NA	Belongs to the ANKRD34 family.	NA	PE2	15
+NX_P0C6P0	Putative protein BCL8	100	11233	8.77	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_P0C6S8	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3	592	64881	8.94	1	Membrane;Mitochondrion	NA	NA	NA	NA	NA	PE1	19
+NX_P0C6T2	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4	37	4193	6.52	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes.	NA	Belongs to the OST4 family.	Protein modification; protein glycosylation.	PE1	2
+NX_P0C7A2	Protein FAM153B	387	43591	4.71	0	NA	NA	NA	NA	Belongs to the FAM153 family.	NA	PE2	5
+NX_P0C7H8	Keratin-associated protein 2-3	128	13480	8.32	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the KRTAP type 2 family.	Keratinization	PE1	17
+NX_P0C7H9	Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7	530	59751	8.09	0	Endoplasmic reticulum;Nucleus	NA	NA	NA	Belongs to the peptidase C19 family. USP17 subfamily.	NA	PE3	8
+NX_P0C7I0	Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8	530	59635	7.3	0	Endoplasmic reticulum;Nucleus	NA	NA	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE3	8
+NX_P0C7I6	Coiled-coil domain-containing protein 159	297	33695	5.64	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	19
+NX_P0C7L1	Serine protease inhibitor Kazal-type 8	97	10821	4.9	0	Secreted	NA	Probable serine protease inhibitor.	NA	NA	NA	PE2	3
+NX_P0C7M3	Surfactant-associated protein 3	94	10526	6.81	0	Cytoplasm;Secreted	NA	Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface.	NA	NA	Surfactant metabolism;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	PE1	14
+NX_P0C7M4	Rhox homeobox family member 2B	288	31637	4.52	0	Nucleus	NA	Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.	NA	Belongs to the paired-like homeobox family. PEPP subfamily.	NA	PE1	X
+NX_P0C7M6	IQ domain-containing protein F3	154	18251	10.51	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_P0C7M7	Acyl-coenzyme A synthetase ACSM4, mitochondrial	580	65703	8.84	0	Mitochondrion	NA	Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Butanoate metabolism;Metabolic pathways;Conjugation of salicylate with glycine	PE1	12
+NX_P0C7M8	C-type lectin domain family 2 member L	214	23927	6.83	1	Membrane	NA	NA	NA	NA	NA	PE1	7
+NX_P0C7N1	Olfactory receptor 8U8	319	36334	8.77	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_P0C7N4	Transmembrane protein 191B	346	39065	8.39	1	Membrane	NA	NA	NA	Belongs to the TMEM191 family.	NA	PE2	22
+NX_P0C7N5	Olfactory receptor 8U9	309	35054	8.4	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_P0C7N8	Olfactory receptor 9G9	305	34020	8.1	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_P0C7P0	CDGSH iron-sulfur domain-containing protein 3, mitochondrial	127	14216	10.56	0	Mitochondrion	NA	Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function.	NA	Belongs to the CISD protein family.	NA	PE1	17
+NX_P0C7P1	RNA-binding motif protein, Y chromosome, family 1 member D	496	55775	9.95	0	Nucleus	NA	RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.	NA	NA	NA	PE2	Y
+NX_P0C7P2	Putative protein RFPL3S	107	11739	10.07	0	NA	NA	NA	NA	NA	NA	PE2	22
+NX_P0C7P3	Protein SLFN14	912	103907	8.57	0	Nucleus	Bleeding disorder, platelet-type 20	Protein SLFN14: Shows no ribosome-associated and endoribonuclease activities.;C-terminally truncated SLFN14 endoribonuclease: Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.	NA	Belongs to the Schlafen family. Subgroup III subfamily.	NA	PE1	17
+NX_P0C7P4	Putative cytochrome b-c1 complex subunit Rieske-like protein 1	283	30815	9.04	0	NA	NA	NA	NA	NA	NA	PE5	22
+NX_P0C7Q2	Age-related maculopathy susceptibility protein 2	107	11437	9.03	0	Cytoplasm	Macular degeneration, age-related, 8	NA	NA	NA	NA	PE1	10
+NX_P0C7Q5	Putative solute carrier family 35 member G4	338	35378	6.77	7	Membrane	NA	NA	NA	Belongs to the SLC35G solute transporter family.	NA	PE5	18
+NX_P0C7Q6	Solute carrier family 35 member G6	338	35103	6.11	9	Membrane	NA	NA	NA	Belongs to the SLC35G solute transporter family.	NA	PE2	17
+NX_P0C7T2	Olfactory receptor 2T7	308	34287	8.56	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	1
+NX_P0C7T3	Olfactory receptor 56A5	313	35317	9.02	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_P0C7T4	Minor histocompatibility protein HMSD variant form	53	6023	5.01	0	NA	NA	This allelic splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. However, associated with GVHD, a favorable graft-versus-leukemia (GVL) can be induced by donor-recipient disparities in mHags. ACC-6 is presented to the cell surface by MHC HLA-B*4403. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. Immunogenicity of most autosomal mHags results from single-nucleotide polymorphisms that cause amino-acid substitutions within epitopes, leading to the differential recognition of peptides between donor and recipient.	NA	NA	NA	PE1	18
+NX_P0C7T5	Ataxin-1-like	689	73306	6.13	0	Nucleoplasm;Dendrite;Nucleus	NA	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity).	NA	Belongs to the ATXN1 family.	NA	PE1	16
+NX_P0C7T7	Putative uncharacterized protein FRMD6-AS1	363	38799	11.74	0	NA	NA	NA	NA	NA	NA	PE5	14
+NX_P0C7T8	Transmembrane protein 253	217	23522	6.71	4	Membrane	NA	NA	NA	NA	NA	PE2	14
+NX_P0C7U0	Protein ELFN1	828	90477	8.67	1	Membrane;Nucleoplasm;Cell junction;Dendrite	NA	Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.	NA	NA	NA	PE1	7
+NX_P0C7U1	Putative inactive neutral ceramidase B	165	19025	9.1	0	NA	NA	NA	NA	Belongs to the neutral ceramidase family.	NA	PE2	10
+NX_P0C7U3	Probable palmitoyltransferase ZDHHC11B	371	41895	8.88	5	Membrane	NA	NA	NA	Belongs to the DHHC palmitoyltransferase family.	NA	PE2	5
+NX_P0C7U9	Protein FAM87A	286	31739	10.05	2	Membrane	NA	NA	NA	Belongs to the FAM87 family.	NA	PE2	8
+NX_P0C7V0	Putative uncharacterized protein encoded by LINC00271	271	29146	11.35	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_P0C7V4	Putative protein FAM90A15P	464	49895	9.95	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_P0C7V6	Putative transcription factor SPT20 homolog-like 2	817	87541	9.02	0	NA	NA	NA	NA	Belongs to the SPT20 family.	NA	PE5	X
+NX_P0C7V7	Putative signal peptidase complex catalytic subunit SEC11B	166	19160	9.66	1	Membrane	NA	Putative component of some signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.	NA	Belongs to the peptidase S26B family.	NA	PE5	8
+NX_P0C7V8	DDB1- and CUL4-associated factor 8-like protein 2	631	71191	4.64	0	NA	NA	NA	NA	Belongs to the WD repeat DCAF8 family.	NA	PE1	X
+NX_P0C7V9	Putative methyltransferase-like protein 15P1	234	26716	5.61	0	NA	NA	Probable S-adenosyl-L-methionine-dependent methyltransferase.	NA	Belongs to the methyltransferase superfamily. RsmH family.	NA	PE5	3
+NX_P0C7W0	Proline-rich protein 29	189	20715	4.83	0	Nucleolus	NA	NA	NA	NA	NA	PE2	17
+NX_P0C7W6	Coiled-coil domain-containing protein 172	258	31035	5.01	0	Cytoplasm;Cilium	NA	NA	NA	Belongs to the CCDC172 family.	NA	PE1	10
+NX_P0C7W8	Putative protein FAM90A13P	464	49853	9.95	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_P0C7W9	Putative protein FAM90A14P	464	49953	9.9	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_P0C7X0	Putative protein FAM90A24P	464	49829	9.95	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_P0C7X1	TBC1 domain family member 3H	549	62219	9.2	0	Cell membrane	NA	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).	Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.;Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.	NA	NA	PE2	17
+NX_P0C7X2	Zinc finger protein 688	276	30575	9.42	0	Nucleoplasm;Cell junction;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_P0C7X3	Putative cyclin-Y-like protein 3	344	39078	7.28	0	NA	NA	NA	NA	Belongs to the cyclin family. Cyclin Y subfamily.	NA	PE3	16
+NX_P0C7X4	Putative ferritin heavy polypeptide-like 19	201	22644	6.65	0	NA	NA	NA	NA	Belongs to the ferritin family.	NA	PE5	X
+NX_P0C7X5	Zinc finger protein 806	589	67808	8.76	0	Nucleus	NA	May function as a transcription factor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE3	2
+NX_P0C841	Putative protein FAM66E	47	5233	6.01	0	NA	NA	NA	NA	Belongs to the FAM66 family.	NA	PE5	8
+NX_P0C842	Putative uncharacterized protein encoded by LINC00614	121	13547	4.49	0	NA	NA	NA	NA	NA	NA	PE5	10
+NX_P0C843	Putative uncharacterized protein encoded by LINC00032	101	12082	10.05	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_P0C851	Phosphoinositide-interacting protein	137	15334	9.86	2	Membrane;Cytosol;Cell membrane	NA	Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity).	NA	NA	NA	PE2	17
+NX_P0C853	Putative uncharacterized protein BAALC-AS2	105	11579	5.82	0	NA	NA	NA	NA	NA	NA	PE5	8
+NX_P0C854	Putative cat eye syndrome critical region protein 9	216	23602	10.5	0	Secreted	NA	NA	NA	NA	NA	PE5	22
+NX_P0C860	Putative male-specific lethal-3 protein-like 2	447	51070	8.6	0	Nucleus	NA	May be involved in chromatin remodeling and transcriptional regulation.	NA	NA	NA	PE5	2
+NX_P0C862	Complement C1q and tumor necrosis factor-related protein 9A	333	34681	8.59	0	Secreted	NA	Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.	NA	NA	NA	PE1	13
+NX_P0C864	Putative uncharacterized protein DANCR	163	16785	10.29	0	NA	NA	NA	NA	NA	NA	PE5	4
+NX_P0C866	Putative uncharacterized protein encoded by LINC00869	280	30847	5.49	0	NA	NA	NA	NA	Belongs to the FAM91 family.	NA	PE5	1
+NX_P0C869	Cytosolic phospholipase A2 beta	781	87978	5.64	0	Early endosome membrane;Cytosol;Mitochondrion membrane	NA	Does have activity against phosphatidylcholine.;Has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine.;Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A.	NA	NA	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;XBP1(S) activates chaperone genes;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Hydrolysis of LPC	PE1	15
+NX_P0C870	Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7	316	35932	5.22	0	Cytoplasm;Nucleus	NA	Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961, PubMed:29915238). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4 (PubMed:28847961). After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery (PubMed:29915238). Acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (PubMed:29915238).	NA	NA	NA	PE1	15
+NX_P0C874	Spermatogenesis-associated protein 31D3	917	102419	8.32	1	Membrane	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA31 family.	NA	PE2	9
+NX_P0C875	Protein FAM228B	324	38070	8.89	0	Golgi apparatus	NA	NA	NA	Belongs to the FAM228 family.	NA	PE1	2
+NX_P0C879	Putative uncharacterized protein FLJ43185	139	14498	12	0	NA	NA	NA	NA	NA	NA	PE5	10
+NX_P0C880	Putative uncharacterized protein FLJ40606	135	14177	11.84	0	NA	NA	NA	NA	NA	NA	PE5	20
+NX_P0C881	Radial spoke head 10 homolog B	870	100635	7.16	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_P0C8F1	Prostate and testis expressed protein 4	98	11407	8.97	0	Secreted;Acrosome	NA	May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility.	NA	Belongs to the PATE family.	NA	PE1	11
+NX_P0CAP1	Myocardial zonula adherens protein	466	54206	5.91	0	Cell membrane;Cell junction;Z line;I band;Cytoskeleton	NA	Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).	NA	Belongs to the MYZAP family.	NA	PE1	15
+NX_P0CAP2	DNA-directed RNA polymerase II subunit GRINL1A	368	41740	6.01	0	Nucleus envelope;Nucleus	NA	May play a role in the Mediator complex-dependent regulation of transcription activation.;Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery.;Acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.	NA	Belongs to the GRINL1 family.	NA	PE1	15
+NX_P0CAT3	Putative TLX1 neighbor protein	122	13375	10.82	0	NA	NA	NA	NA	NA	NA	PE5	10
+NX_P0CB33	Putative zinc finger protein 735	412	47565	9.31	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE5	7
+NX_P0CB38	Polyadenylate-binding protein 4-like	370	41854	9.53	0	NA	NA	May bind RNA.	NA	Belongs to the polyadenylate-binding protein type-1 family.	NA	PE1	4
+NX_P0CB47	Upstream-binding factor 1-like protein 1	393	46134	9.52	0	Cytoplasm;Nucleus	NA	Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development.	NA	NA	NA	PE2	11
+NX_P0CB48	Putative upstream-binding factor 1-like protein 6	400	46551	9.11	0	Nucleus	NA	NA	NA	NA	NA	PE5	2
+NX_P0CE67	Putative uncharacterized protein C3orf79	100	11337	9.02	0	NA	NA	NA	NA	NA	NA	PE4	3
+NX_P0CE71	Putative oncomodulin-2	109	12129	4.11	0	NA	NA	NA	NA	Belongs to the parvalbumin family.	NA	PE5	7
+NX_P0CE72	Oncomodulin-1	109	12184	4.19	0	NA	NA	Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.	NA	Belongs to the parvalbumin family.	NA	PE1	7
+NX_P0CF51	T cell receptor gamma constant 1	173	19804	7.7	1	Cell membrane	NA	Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	7
+NX_P0CF74	Immunoglobulin lambda constant 6	106	11277	6.91	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P0CF75	Endogenous Bornavirus-like nucleoprotein 1	366	40313	7	0	NA	NA	May act as an RNA-binding protein. Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity).	NA	NA	NA	PE2	10
+NX_P0CF97	Protein FAM200B	657	76034	8.33	0	NA	NA	NA	NA	Belongs to the FAM200 family.	NA	PE1	4
+NX_P0CG00	Putative zinc finger and SCAN domain-containing protein 5D	497	56244	8.95	0	Nucleus	NA	NA	NA	NA	NA	PE5	11
+NX_P0CG01	Gastrokine-3	181	20221	8.64	0	Secreted	NA	May inhibit gastric epithelial cell proliferation.	NA	Belongs to the gastrokine family.	NA	PE3	2
+NX_P0CG04	Immunoglobulin lambda constant 1	106	11348	7.89	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P0CG08	Golgi pH regulator B	455	52917	9.34	9	Endoplasmic reticulum;Golgi apparatus membrane	NA	Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.	NA	Belongs to the Golgi pH regulator (TC 1.A.38) family.	NA	PE1	1
+NX_P0CG12	Decreased expression in renal and prostate cancer protein	524	51391	12.42	0	Nucleoplasm;Nucleus	NA	Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.	NA	Belongs to the DERPC family.	NA	PE1	16
+NX_P0CG13	Chromosome transmission fidelity protein 8 homolog	121	13314	7.9	0	Nucleus	NA	Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.	NA	Belongs to the CTF8 family.	NA	PE1	16
+NX_P0CG20	Proline-rich protein 35	571	59354	9.16	0	NA	NA	NA	NA	NA	NA	PE1	16
+NX_P0CG21	NHL-repeat-containing protein 4	123	12631	4.78	0	Mitochondrion	NA	NA	NA	NA	NA	PE2	16
+NX_P0CG22	Putative dehydrogenase/reductase SDR family member 4-like 1	281	30608	9.81	0	NA	NA	Putative oxidoreductase.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	NA	PE5	14
+NX_P0CG23	Zinc finger protein 853	659	74878	5.19	0	Nucleolus	NA	NA	NA	NA	NA	PE1	7
+NX_P0CG24	Zinc finger protein 883	379	43967	9.03	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE2	9
+NX_P0CG29	Glutathione S-transferase theta-2	244	27506	6.53	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.	NA	Belongs to the GST superfamily. Theta family.	Glutathione conjugation	PE1	22
+NX_P0CG30	Glutathione S-transferase theta-2B	244	27507	5.99	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.	NA	Belongs to the GST superfamily. Theta family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation	PE1	22
+NX_P0CG31	Putative zinc finger protein 286B	522	59572	8.7	0	Cytosol;Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE5	17
+NX_P0CG32	Zinc finger CCHC domain-containing protein 18	403	45160	7.02	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the ZCCHC12 family.	NA	PE2	X
+NX_P0CG33	Golgin subfamily A member 6D	693	79896	5.37	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE1	15
+NX_P0CG34	Thymosin beta-15A	45	5229	5.31	0	Cytoskeleton	NA	Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).	NA	Belongs to the thymosin beta family.	NA	PE1	X
+NX_P0CG35	Thymosin beta-15B	45	5229	5.31	0	Cytoskeleton	NA	Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration.	NA	Belongs to the thymosin beta family.	NA	PE1	X
+NX_P0CG36	Cryptic family protein 1B	223	24642	9.04	0	Secreted	NA	NA	NA	Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.	NA	PE2	2
+NX_P0CG37	Cryptic protein	223	24612	9.14	0	Secreted;Cell membrane	Heterotaxy, visceral, 2, autosomal	NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.	N-glycosylated.	Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.	Signaling by NODAL;Regulation of signaling by NODAL	PE1	2
+NX_P0CG38	POTE ankyrin domain family member I	1075	121282	5.83	0	NA	NA	NA	NA	In the N-terminal section; belongs to the POTE family.;In the C-terminal section; belongs to the actin family.	NA	PE1	2
+NX_P0CG39	POTE ankyrin domain family member J	1038	117390	5.66	0	NA	NA	NA	NA	In the N-terminal section; belongs to the POTE family.;In the C-terminal section; belongs to the actin family.	NA	PE1	2
+NX_P0CG40	Transcription factor Sp9	484	48915	9.05	0	Mitochondrion;Nucleus	NA	Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	2
+NX_P0CG41	cTAGE family member 8	777	88077	5.23	1	Membrane	NA	NA	NA	Belongs to the cTAGE family.	NA	PE2	7
+NX_P0CG42	Putative protein FAM157B	384	43129	11.41	0	NA	NA	NA	NA	Belongs to the FAM157 family.	NA	PE3	9
+NX_P0CG43	Putative protein FAM157C	387	43408	11.19	0	NA	NA	NA	NA	Belongs to the FAM157 family.	NA	PE3	16
+NX_P0CG47	Polyubiquitin-B	229	25762	6.86	0	Cytoplasm;Nucleus	NA	Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.	Ubiquitin: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.;Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).	Belongs to the ubiquitin family.	Parkinson's disease;Activation of NF-kappaB in B cells;ER-Phagosome pathway;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;ISG15 antiviral mechanism;Translesion Synthesis by POLH;Regulation of PLK1 Activity at G2/M Transition;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;NOD1/2 Signaling Pathway;Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;Stimuli-sensing channels;Senescence-Associated Secretory Phenotype (SASP);Amyloid fiber formation;p75NTR recruits signalling complexes;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Negative regulation of MAPK pathway;Circadian Clock;EGFR downregulation;TCF dependent signaling in response to WNT;Iron uptake and transport;APC/C:Cdc20 mediated degradation of Cyclin B;APC-Cdc20 mediated degradation of Nek2A;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;Downregulation of TGF-beta receptor signaling;Deactivation of the beta-catenin transactivating complex;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Oncogene Induced Senescence;Glycogen synthesis;Myoclonic epilepsy of Lafora;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;Regulation of FZD by ubiquitination;Regulation of innate immune responses to cytosolic DNA;ER Quality Control Compartment (ERQC);Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;Activated NOTCH1 Transmits Signal to the Nucleus;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Cyclin D associated events in G1;Regulation of signaling by CBL;ABC-family proteins mediated transport;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Spry regulation of FGF signaling;Downregulation of ERBB4 signaling;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;IRAK2 mediated activation of TAK1 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Recognition of DNA damage by PCNA-containing replication complex;Downregulation of ERBB2:ERBB3 signaling;NF-kB is activated and signals survival;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Assembly Of The HIV Virion;NRIF signals cell death from the nucleus;Regulation of necroptotic cell death;Defective CFTR causes cystic fibrosis;Stabilization of p53;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Pink/Parkin Mediated Mitophagy;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Formation of Incision Complex in GG-NER;Fanconi Anemia Pathway;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;UCH proteinases;Ub-specific processing proteases;Ovarian tumor domain proteases;Josephin domain DUBs;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Metalloprotease DUBs;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Negative regulation of MET activity;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;TICAM1, RIP1-mediated IKK complex recruitment;Regulation of PTEN localization;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;NOTCH3 Activation and Transmission of Signal to the Nucleus;Peroxisomal protein import;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	17
+NX_P0CG48	Polyubiquitin-C	685	77039	7.16	0	Cytoplasm;Nucleus	NA	Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.	Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).;Ubiquitin: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.	Belongs to the ubiquitin family.	PPAR signaling pathway;Activation of NF-kappaB in B cells;ER-Phagosome pathway;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;ISG15 antiviral mechanism;Translesion Synthesis by POLH;Regulation of PLK1 Activity at G2/M Transition;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;NOD1/2 Signaling Pathway;Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;Stimuli-sensing channels;Senescence-Associated Secretory Phenotype (SASP);Amyloid fiber formation;p75NTR recruits signalling complexes;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Negative regulation of MAPK pathway;Circadian Clock;EGFR downregulation;TCF dependent signaling in response to WNT;Iron uptake and transport;APC/C:Cdc20 mediated degradation of Cyclin B;APC-Cdc20 mediated degradation of Nek2A;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;Downregulation of TGF-beta receptor signaling;Deactivation of the beta-catenin transactivating complex;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Oncogene Induced Senescence;Glycogen synthesis;Myoclonic epilepsy of Lafora;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;Regulation of FZD by ubiquitination;Regulation of innate immune responses to cytosolic DNA;ER Quality Control Compartment (ERQC);Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;Activated NOTCH1 Transmits Signal to the Nucleus;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Cyclin D associated events in G1;Regulation of signaling by CBL;ABC-family proteins mediated transport;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Spry regulation of FGF signaling;Downregulation of ERBB4 signaling;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;IRAK2 mediated activation of TAK1 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Recognition of DNA damage by PCNA-containing replication complex;Downregulation of ERBB2:ERBB3 signaling;NF-kB is activated and signals survival;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Assembly Of The HIV Virion;NRIF signals cell death from the nucleus;Regulation of necroptotic cell death;Defective CFTR causes cystic fibrosis;Stabilization of p53;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Pink/Parkin Mediated Mitophagy;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Formation of Incision Complex in GG-NER;Fanconi Anemia Pathway;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;UCH proteinases;Ub-specific processing proteases;Ovarian tumor domain proteases;Josephin domain DUBs;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Metalloprotease DUBs;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Negative regulation of MET activity;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;TICAM1, RIP1-mediated IKK complex recruitment;Regulation of PTEN localization;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;NOTCH3 Activation and Transmission of Signal to the Nucleus;Peroxisomal protein import;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	12
+NX_P0CH98	Protein FAM106C	169	18676	5.62	0	NA	NA	NA	NA	Belongs to the FAM106 family.	NA	PE3	17
+NX_P0CH99	Zinc finger protein 705D	300	34712	9.14	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	8
+NX_P0CI00	Putative zinc finger protein 705B	300	34732	9.08	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE5	8
+NX_P0CI01	Speedy protein E6	402	48330	9.78	0	NA	NA	NA	NA	Belongs to the Speedy/Ringo family.	NA	PE2	7
+NX_P0CI25	Tripartite motif-containing protein 49	452	52888	7.53	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE1	11
+NX_P0CI26	Tripartite motif-containing protein 49C	452	52933	7.28	0	NA	NA	NA	NA	NA	NA	PE2	11
+NX_P0CJ68	Humanin-like 1	24	2691	9.49	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective and antiapoptotic factor.	NA	Belongs to the humanin family.	NA	PE2	17
+NX_P0CJ69	Humanin-like 2	28	3081	7.98	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective and antiapoptotic factor.	NA	Belongs to the humanin family.	NA	PE2	5
+NX_P0CJ70	Humanin-like 3	24	2796	10.69	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective and antiapoptotic factor.	NA	Belongs to the humanin family.	NA	PE2	20
+NX_P0CJ71	Humanin-like 4	28	3247	9.19	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective and antiapoptotic factor.	NA	Belongs to the humanin family.	NA	PE2	16
+NX_P0CJ72	Humanin-like 5	24	2666	7.98	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective and antiapoptotic factor.	NA	Belongs to the humanin family.	NA	PE2	10
+NX_P0CJ73	Humanin-like 6	24	2719	9.49	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective and antiapoptotic factor.	NA	Belongs to the humanin family.	NA	PE2	7
+NX_P0CJ74	Humanin-like 7	24	2647	7.98	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective and antiapoptotic factor.	NA	Belongs to the humanin family.	NA	PE2	10
+NX_P0CJ75	Humanin-like 8	24	2661	9.49	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective and antiapoptotic factor.	NA	Belongs to the humanin family.	NA	PE2	11
+NX_P0CJ76	Humanin-like 9	24	2694	11.54	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective and antiapoptotic factor.	NA	Belongs to the humanin family.	NA	PE2	6
+NX_P0CJ77	Humanin-like 10	24	2806	10.69	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective and antiapoptotic factor.	NA	Belongs to the humanin family.	NA	PE2	X
+NX_P0CJ78	Zinc finger protein 865	1059	111077	9.4	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P0CJ79	Zinc finger protein 888	718	83549	9.33	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P0CJ85	Double homeobox protein 4-like protein 2	424	44926	8.72	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE3	4
+NX_P0CJ86	Double homeobox protein 4-like protein 3	424	44926	8.72	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE3	4
+NX_P0CJ87	Double homeobox protein 4-like protein 4	422	44826	8.36	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE3	4
+NX_P0CJ88	Double homeobox protein 4-like protein 5	424	44926	8.72	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE3	4
+NX_P0CJ89	Double homeobox protein 4-like protein 6	424	44926	8.72	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE3	4
+NX_P0CJ90	Double homeobox protein 4-like protein 7	424	44926	8.72	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE3	4
+NX_P0CJ92	Golgin subfamily A member 8H	632	71342	8.15	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE2	15
+NX_P0CK96	Solute carrier family 35 member E2B	405	43777	8.65	10	Membrane	NA	Putative transporter.	NA	Belongs to the TPT transporter family. SLC35E subfamily.	NA	PE1	1
+NX_P0CK97	Solute carrier family 35 member E2A	266	29079	8.28	4	Membrane;Nucleoplasm	NA	Putative transporter.	NA	Belongs to the TPT transporter family. SLC35E subfamily.	NA	PE2	1
+NX_P0CL80	G antigen 12F	117	12978	4.3	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_P0CL81	G antigen 12G	117	12978	4.3	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_P0CL82	G antigen 12I	117	12978	4.3	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_P0CL83	Putative STAG3-like protein 1	205	23775	7.61	0	Nucleus	NA	NA	NA	Belongs to the SCC3 family.	NA	PE5	7
+NX_P0CL84	Putative STAG3-like protein 2	134	15630	8.27	0	Nucleus	NA	NA	NA	Belongs to the SCC3 family.	NA	PE5	7
+NX_P0CL85	STAG3-like protein 3	134	15609	7.57	0	Nucleus	NA	NA	NA	Belongs to the SCC3 family.	NA	PE2	7
+NX_P0CV98	Testis-specific Y-encoded protein 3	308	35101	5.23	0	NA	NA	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	Y
+NX_P0CV99	Testis-specific Y-encoded protein 4	314	35727	5.12	0	NA	NA	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE2	Y
+NX_P0CW00	Testis-specific Y-encoded protein 8	308	35147	5.16	0	NA	NA	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE2	Y
+NX_P0CW01	Testis-specific Y-encoded protein 10	308	35101	5.23	0	NA	NA	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE2	Y
+NX_P0CW18	Serine protease 56	603	64597	9.15	0	NA	Microphthalmia, isolated, 6	Serine protease required during eye development.	NA	Belongs to the peptidase S1 family.	NA	PE1	2
+NX_P0CW19	LIM and senescent cell antigen-like-containing domain protein 3	117	13251	5.38	0	Cytoplasm	NA	NA	NA	NA	NA	PE2	2
+NX_P0CW20	LIM and senescent cell antigen-like-containing domain protein 4	117	13251	5.38	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_P0CW21	Putative uncharacterized protein SPART-AS1	52	6167	9.69	0	NA	NA	NA	NA	NA	NA	PE5	13
+NX_P0CW23	A-kinase anchor protein inhibitor 1	69	7848	6.73	0	NA	NA	Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177).	NA	NA	NA	PE1	18
+NX_P0CW24	Paraneoplastic antigen-like protein 6A	399	43875	5.24	0	Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the PNMA family.	NA	PE1	X
+NX_P0CW27	Coiled-coil domain-containing protein 166	439	48709	10.6	0	NA	NA	NA	NA	NA	NA	PE1	8
+NX_P0CZ25	Uncharacterized protein DNAH10OS	163	17537	9.57	0	NA	NA	NA	NA	NA	NA	PE2	12
+NX_P0DH78	RING finger protein 224	156	16549	7.43	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_P0DI80	Small integral membrane protein 6	62	7017	3.72	1	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE2	17
+NX_P0DI81	Trafficking protein particle complex subunit 2	140	16445	6.02	0	Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Endoplasmic reticulum;Nucleoplasm;Cytoplasmic vesicle;Perinuclear region;Nucleus	Spondyloepiphyseal dysplasia tarda	Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi.	NA	Belongs to the TRAPP small subunits family. Sedlin subfamily.	COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs	PE1	X
+NX_P0DI82	Trafficking protein particle complex subunit 2B	140	16445	6.02	0	Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Endoplasmic reticulum;Nucleoplasm;Cytoplasmic vesicle;Perinuclear region;Nucleus	NA	Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi.	NA	Belongs to the TRAPP small subunits family. Sedlin subfamily.	NA	PE1	19
+NX_P0DI83	Ras-related protein Rab-34, isoform NARR	198	21118	12.15	0	Nucleus;Nucleolus	NA	NA	Phosphorylated during M-phase.	NA	NA	PE1	17
+NX_P0DJ07	Protein PET100 homolog, mitochondrial	73	9114	6.31	1	Membrane;Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the PET100 family.	NA	PE1	19
+NX_P0DJ93	Small integral membrane protein 13	91	10351	6.17	1	Membrane;Nucleoplasm;Golgi apparatus;Nucleus membrane	NA	NA	NA	Belongs to the SMIM13 family.	NA	PE1	6
+NX_P0DJD0	RANBP2-like and GRIP domain-containing protein 1	1748	196662	5.8	0	NA	NA	NA	NA	NA	NA	PE2	2
+NX_P0DJD1	RANBP2-like and GRIP domain-containing protein 2	1756	197308	5.85	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_P0DJD3	RNA-binding motif protein, Y chromosome, family 1 member A1	496	55784	9.95	0	Nucleus	NA	RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.	NA	NA	NA	PE1	Y
+NX_P0DJD4	RNA-binding motif protein, Y chromosome, family 1 member C	496	55784	9.93	0	Nucleus	NA	RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.	NA	NA	NA	PE1	Y
+NX_P0DJD7	Pepsin A-4	388	41977	4.16	0	Secreted	NA	Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	NA	Belongs to the peptidase A1 family.	Surfactant metabolism	PE1	11
+NX_P0DJD8	Pepsin A-3	388	41976	4.22	0	Secreted	NA	Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	NA	Belongs to the peptidase A1 family.	Surfactant metabolism	PE1	11
+NX_P0DJD9	Pepsin A-5	388	41993	4.21	0	Secreted	NA	Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.	NA	Belongs to the peptidase A1 family.	Surfactant metabolism	PE1	11
+NX_P0DJG4	Testicular haploid expressed gene protein-like	465	53028	9.33	0	NA	NA	NA	NA	NA	NA	PE1	4
+NX_P0DJH9	Protein RD3-like	198	23209	5.98	0	NA	NA	NA	NA	NA	NA	PE2	14
+NX_P0DJI8	Serum amyloid A-1 protein	122	13532	6.28	0	Secreted	NA	Major acute phase protein.	This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.	Belongs to the SAA family.	G alpha (i) signalling events;G alpha (q) signalling events;Advanced glycosylation endproduct receptor signaling;Amyloid fiber formation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;Formyl peptide receptors bind formyl peptides and many other ligands;Scavenging by Class B Receptors;Interleukin-4 and Interleukin-13 signaling	PE1	11
+NX_P0DJI9	Serum amyloid A-2 protein	122	13527	9.2	0	Secreted	NA	Major acute phase reactant. Apolipoprotein of the HDL complex.	This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.	Belongs to the SAA family.	NA	PE1	11
+NX_P0DJJ0	SLIT-ROBO Rho GTPase-activating protein 2C	459	53484	5.98	0	NA	NA	Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory.	NA	NA	NA	PE1	1
+NX_P0DJR0	GTPase IMAP family member GIMD1	217	24463	8.18	0	NA	NA	NA	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.	NA	PE1	4
+NX_P0DKB5	Trophoblast glycoprotein-like	382	40400	8.64	1	Membrane	NA	NA	NA	NA	NA	PE1	11
+NX_P0DKB6	Mitochondrial pyruvate carrier 1-like protein	136	15138	9.95	2	Membrane	NA	NA	NA	Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.	NA	PE1	X
+NX_P0DKL9	ARL14 effector protein-like	152	17712	8.71	0	NA	NA	NA	NA	NA	NA	PE1	5
+NX_P0DKV0	Putative spermatogenesis-associated protein 31C1	1188	130522	9.52	1	Membrane	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA31 family.	NA	PE5	9
+NX_P0DKX0	Zinc finger protein 728	622	71801	9.32	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_P0DKX4	Small integral membrane protein 18	95	11088	6.7	1	Membrane;Nucleoplasm;Centrosome	NA	NA	NA	NA	NA	PE2	8
+NX_P0DL12	Small integral membrane protein 17	118	13332	4.56	1	Membrane;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE2	19
+NX_P0DM35	Metallothionein 1H-like protein 1	61	6094	8.75	0	NA	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	NA	Belongs to the metallothionein superfamily. Type 1 family.	NA	PE2	1
+NX_P0DM63	Nuclear pore complex-interacting protein family member A8	369	42230	9.22	0	NA	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_P0DMB1	Proline-rich protein 23D2	279	31050	6.08	0	NA	NA	NA	NA	Belongs to the PRR23 family.	NA	PE2	8
+NX_P0DMB2	Uncharacterized protein C8orf88	117	13372	9.81	0	NA	NA	NA	NA	NA	NA	PE1	8
+NX_P0DMC3	Apelin receptor early endogenous ligand	54	6622	12.22	0	Secreted;Extracellular space	NA	Endogenous ligand for the apelin receptor (APLNR) (PubMed:25639753, PubMed:28137936). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:25639753, PubMed:28137936). Drives internalization of APLNR. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating APLNR. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. The position of the future vessel formation, during vasculogenesis. Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Plays a role in placental vascular development; promotes placental trophoblast invasion and spiral artery remodeling in the uterus. Involved in the regulation of maternal cardiovascular homeostasis to prevent gestational hypertension and for potent cardioprotective functions during heart failure. Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity).	NA	Belongs to the Elabela/Toddler family.	NA	PE1	4
+NX_P0DME0	Protein SETSIP	302	34882	4.2	0	Cytoplasm;Nucleus	NA	Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter.	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	1
+NX_P0DML2	Chorionic somatomammotropin hormone 1	217	25020	5.34	0	Secreted	NA	Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.	NA	Belongs to the somatotropin/prolactin family.	Prolactin receptor signaling;Growth hormone receptor signaling	PE1	17
+NX_P0DML3	Chorionic somatomammotropin hormone 2	217	24994	5.34	0	Secreted	NA	Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.	NA	Belongs to the somatotropin/prolactin family.	NA	PE1	17
+NX_P0DMM9	Sulfotransferase 1A3	295	34196	5.68	0	Cytoplasm	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.	The N-terminus is blocked.	Belongs to the sulfotransferase 1 family.	XBP1(S) activates chaperone genes;Cytosolic sulfonation of small molecules	PE1	16
+NX_P0DMN0	Sulfotransferase 1A4	295	34196	5.68	0	Cytoplasm	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.	The N-terminus is blocked.	Belongs to the sulfotransferase 1 family.	Cytosolic sulfonation of small molecules	PE1	16
+NX_P0DMP1	Humanin-like 12	27	2961	9.49	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective and antiapoptotic factor.	NA	Belongs to the humanin family.	NA	PE2	3
+NX_P0DMP2	SLIT-ROBO Rho GTPase-activating protein 2B	458	53406	6.46	0	NA	NA	May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.	NA	NA	NA	PE2	1
+NX_P0DMQ5	Putative transmembrane protein INAFM2	153	15439	9.3	1	Membrane	NA	NA	NA	NA	NA	PE1	15
+NX_P0DMQ9	Putative uncharacterized protein C8orf89	161	18160	9.49	0	NA	NA	NA	NA	NA	NA	PE2	8
+NX_P0DMR1	Heterogeneous nuclear ribonucleoprotein C-like 4	293	32029	5.48	0	Nucleus	NA	NA	NA	Belongs to the RRM HNRPC family. RALY subfamily.	NA	PE1	1
+NX_P0DMR2	Secretoglobin family 1C member 2	95	10457	4.7	0	Secreted	NA	NA	NA	Belongs to the secretoglobin family.	NA	PE2	17
+NX_P0DMR3	Putative protein ATXN8OS	200	22759	8.47	0	Cytoplasm	NA	NA	NA	NA	NA	PE5	13
+NX_P0DMS8	Adenosine receptor A3	318	36185	9.11	7	Cell membrane	NA	Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299).	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Adenosine P1 receptors	PE1	1
+NX_P0DMS9	Transmembrane domain-containing protein TMIGD3	266	30327	8.9	2	Membrane	NA	Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).	NA	NA	NA	PE1	1
+NX_P0DMT0	Myoregulin	46	5194	5.97	1	Sarcoplasmic reticulum membrane	NA	Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle.	NA	NA	NA	PE2	10
+NX_P0DMU2	Putative olfactory receptor 8G3 pseudogene	310	34506	7.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE5	11
+NX_P0DMU3	FAM231A/C-like protein LOC102723383	169	18266	8.91	0	Cytoskeleton	NA	NA	NA	Belongs to the FAM231 family.	NA	PE3	1
+NX_P0DMU7	Cancer/testis antigen family 45 member A6	189	21232	9.72	0	NA	NA	NA	NA	Belongs to the CT45 family.	NA	PE2	X
+NX_P0DMU8	Cancer/testis antigen family 45 member A5	189	21232	9.72	0	NA	NA	NA	NA	Belongs to the CT45 family.	NA	PE2	X
+NX_P0DMU9	Cancer/testis antigen family 45 member A10	189	21145	9.61	0	NA	NA	NA	NA	Belongs to the CT45 family.	NA	PE1	X
+NX_P0DMV0	Cancer/testis antigen family 45 member A7	189	21232	9.72	0	NA	NA	NA	NA	Belongs to the CT45 family.	NA	PE2	X
+NX_P0DMV1	Cancer/testis antigen family 45 member A8	189	21363	9.67	0	NA	NA	NA	NA	Belongs to the CT45 family.	NA	PE2	X
+NX_P0DMV2	Cancer/testis antigen family 45 member A9	189	21363	9.67	0	NA	NA	NA	NA	Belongs to the CT45 family.	NA	PE2	X
+NX_P0DMV8	Heat shock 70 kDa protein 1A	641	70052	5.48	0	Cytoplasm;Centrosome;Nucleus	NA	(Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.;Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401).	In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.;HSPA1A is phosphorylated by ABL2 (Phosphotyrosine:PTM-0255)	Belongs to the heat shock protein 70 family.	AUF1 (hnRNP D0) binds and destabilizes mRNA;Regulation of HSF1-mediated heat shock response;Attenuation phase;HSF1-dependent transactivation;Viral RNP Complexes in the Host Cell Nucleus;Neutrophil degranulation;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	6
+NX_P0DMV9	Heat shock 70 kDa protein 1B	641	70052	5.48	0	Cytoplasm;Centrosome	NA	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).;(Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.	In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.	Belongs to the heat shock protein 70 family.	Regulation of HSF1-mediated heat shock response;Attenuation phase;HSF1-dependent transactivation;Neutrophil degranulation;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	6
+NX_P0DMW2	NLR family pyrin domain-containing protein 2B	45	4993	5.92	0	Cytoplasm;Nucleus	NA	May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at 'Ser-536', thereby inhibiting its transcriptional activity. Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity. May also play a role in cell cycle progression and apoptotic process.	NA	NA	NA	PE2	X
+NX_P0DMW3	Small integral membrane protein 10-like protein 1	68	7391	10.02	0	NA	NA	NA	NA	NA	NA	PE1	12
+NX_P0DMW4	Small integral membrane protein 10-like protein 2A	78	8389	11.25	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_P0DMW5	Small integral membrane protein 10-like protein 2B	78	8389	11.25	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_P0DN24	Uncharacterized protein C3orf86	101	10933	7.77	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_P0DN25	C1GALT1-specific chaperone 1-like protein	315	36396	5.41	1	Membrane	NA	NA	NA	Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.	NA	PE2	2
+NX_P0DN26	Peptidyl-prolyl cis-trans isomerase A-like 4F	164	18197	9.43	0	Cytoplasm	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).	NA	Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.	NA	PE3	1
+NX_P0DN37	Peptidyl-prolyl cis-trans isomerase A-like 4G	164	18166	9.19	0	Cytoplasm	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).	NA	Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.	NA	PE2	1
+NX_P0DN76	Splicing factor U2AF 35 kDa subunit-like protein	240	27872	9.09	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.	NA	Belongs to the splicing factor SR family.	NA	PE1	21
+NX_P0DN77	Medium-wave-sensitive opsin 2	364	40584	8.9	7	Cell membrane	NA	Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.	Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.;N-glycosylated. O-glycosylated.	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	NA	PE2	X
+NX_P0DN78	Medium-wave-sensitive opsin 3	364	40584	8.9	7	Cell membrane	NA	Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.	N-glycosylated. O-glycosylated.;Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	NA	PE2	X
+NX_P0DN79	Cystathionine beta-synthase-like protein	551	60587	6.2	0	Cytoplasmic vesicle;Nucleus;Cytoplasm;Nucleolus	NA	Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.	NA	Belongs to the cysteine synthase/cystathionine beta-synthase family.	Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.;Cysteine formation from homocysteine	PE1	21
+NX_P0DN80	Olfactory receptor 5H8	308	34772	7.05	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE3	3
+NX_P0DN81	Olfactory receptor 13C7	318	34899	9.01	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE3	9
+NX_P0DN82	Olfactory receptor 12D1	309	35330	9.29	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE3	6
+NX_P0DN84	Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF	35	3836	6.5	1	Sarcoplasmic reticulum membrane	NA	Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).	NA	NA	NA	PE2	3
+NX_P0DN86	Choriogonadotropin subunit beta 3	165	17739	8.49	0	Secreted	NA	Beta subunit of the human chorionic gonadotropin (hCG). HCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.	NA	Belongs to the glycoprotein hormones subunit beta family.	Glycoprotein hormones;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	PE1	19
+NX_P0DN87	Choriogonadotropin subunit beta 7	165	17757	8.66	0	Secreted	NA	Beta subunit of the human chorionic gonadotropin (hCG). HCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.	NA	Belongs to the glycoprotein hormones subunit beta family.	NA	PE2	19
+NX_P0DO92	Putative protein T-ENOL	83	9002	8.53	0	NA	NA	NA	NA	NA	NA	PE1	16
+NX_P0DO97	Coiled-coil domain-containing protein 192	292	32479	4.98	0	NA	NA	NA	NA	NA	NA	PE1	5
+NX_P0DOY2	Immunoglobulin lambda constant 2	106	11294	6.91	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P0DOY3	Immunoglobulin lambda constant 3	106	11266	6.91	0	Secreted;Cell membrane	NA	Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P0DOY5	Immunoglobulin heavy diversity 1-1	5	435	5.53	0	Secreted;Cell membrane	NA	D region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE4	14
+NX_P0DP01	Immunoglobulin heavy variable 1-8	117	12992	9.26	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_P0DP02	Immunoglobulin heavy variable 3-30-3	117	12989	9.12	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE3	14
+NX_P0DP03	Immunoglobulin heavy variable 3-30-5	117	12947	9.1	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE3	14
+NX_P0DP04	Immunoglobulin heavy variable 3-43D	118	13017	5.28	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE3	14
+NX_P0DP06	Immunoglobulin heavy variable 4-30-4	118	13156	9.33	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE3	14
+NX_P0DP07	Immunoglobulin heavy variable 4-31	118	13095	9.33	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_P0DP08	Immunoglobulin heavy variable 4-38-2	117	13016	9.36	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	14
+NX_P0DP09	Immunoglobulin kappa variable 1-13	117	12569	7.68	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	NA	PE1	2
+NX_P0DP23	Calmodulin-1	149	16838	4.09	0	Cytoplasmic vesicle;Spindle pole;Spindle;Centrosome	Long QT syndrome 14;Ventricular tachycardia, catecholaminergic polymorphic, 4	(Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity.;Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).	Phosphorylation results in a decreased activity.;Ubiquitination results in a strongly decreased activity.	Belongs to the calmodulin family.	RAF/MAP kinase cascade;Ion transport by P-type ATPases;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Uptake and function of anthrax toxins;FCERI mediated Ca+2 mobilization;VEGFR2 mediated vascular permeability;Stimuli-sensing channels;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Ras activation upon Ca2+ influx through NMDA receptor;Transcriptional activation of mitochondrial biogenesis;RAF activation;Inactivation, recovery and regulation of the phototransduction cascade;Platelet degranulation;PKA activation;DARPP-32 events;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Synthesis of IP3 and IP4 in the cytosol;eNOS activation;Smooth Muscle Contraction;Glycogen breakdown (glycogenolysis);VEGFR2 mediated cell proliferation;Activation of Ca-permeable Kainate Receptor;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;Calmodulin induced events;CREB1 phosphorylation through the activation of Adenylate Cyclase;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;CLEC7A (Dectin-1) induces NFAT activation;Cam-PDE 1 activation;CaMK IV-mediated phosphorylation of CREB;CaM pathway;Phase 0 - rapid depolarisation;Ion homeostasis;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Protein methylation;Calcineurin activates NFAT;Regulation of MECP2 expression and activity;Loss of phosphorylation of MECP2 at T308;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation;Extra-nuclear estrogen signaling;Activation of AMPK downstream of NMDARs;Activation of RAC1 downstream of NMDARs	PE1	14
+NX_P0DP24	Calmodulin-2	149	16838	4.09	0	Spindle pole;Spindle;Centrosome	Long QT syndrome 15	Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).	Phosphorylation results in a decreased activity.;Ubiquitination results in a strongly decreased activity.	Belongs to the calmodulin family.	NA	PE1	2
+NX_P0DP25	Calmodulin-3	149	16838	4.09	0	Spindle pole;Spindle;Centrosome	NA	Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.	Ubiquitination results in a strongly decreased activity.;Phosphorylation results in a decreased activity.	Belongs to the calmodulin family.	NA	PE1	19
+NX_P0DP42	Transmembrane protein 225B	221	25027	5.35	4	Membrane	NA	NA	NA	NA	NA	PE1	7
+NX_P0DP57	Secreted Ly-6/uPAR domain-containing protein 2	97	10160	6.14	0	Secreted	NA	Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner.	NA	NA	NA	PE1	8
+NX_P0DP58	Ly-6/neurotoxin-like protein 1	116	12641	8.04	0	Endoplasmic reticulum;Dendrite;Cell membrane	NA	Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:21252236). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR (By similarity). In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs (PubMed:28100642). Prevents plasticity in the primary visual cortex late in life (By similarity).	NA	NA	NA	PE1	8
+NX_P0DP71	Protein FAM236C	79	8682	8.8	0	NA	NA	NA	NA	Belongs to the FAM236 family.	NA	PE2	X
+NX_P0DP72	V-set and immunoglobulin domain-containing protein 10-like 2	767	81629	5.95	1	Membrane	NA	NA	NA	NA	NA	PE2	11
+NX_P0DP73	Beta-defensin 130B	79	8736	9.47	0	Secreted	NA	Antimicrobial host-defense peptide. Has an antiplasmodial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	8
+NX_P0DP74	Beta-defensin 130A	79	8736	9.47	0	Secreted	NA	Antimicrobial host-defense peptide. Has an antiplasmodial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	8
+NX_P0DP75	Putative uncharacterized protein MED14OS	135	14289	12.24	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_P0DP91	Chimeric ERCC6-PGBD3 protein	1061	119487	6.15	0	Nucleus	Premature ovarian failure 11	Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6. In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7. In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.	NA	NA	NA	PE1	10
+NX_P0DPA2	V-set and immunoglobulin domain-containing protein 8	414	43891	6.84	1	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_P0DPA3	Putative uncharacterized protein SNHG28	235	25086	9.42	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_P0DPB3	Schwannomin-interacting protein 1	487	53480	4.98	0	Cytoplasm	NA	NA	NA	Belongs to the SCHIP1 family.	NA	PE1	3
+NX_P0DPB5	Protein POLR1D, isoform 2	122	14332	9.88	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	NA	NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;B-WICH complex positively regulates rRNA expression	PE1	13
+NX_P0DPB6	DNA-directed RNA polymerases I and III subunit RPAC2	133	15237	5.55	0	Nucleus	Treacher Collins syndrome 2	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.	NA	Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.	NA	PE1	13
+NX_P0DPD5	Zinc finger protein 723	513	59152	9.39	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE2	19
+NX_P0DPD6	Endothelin-converting enzyme 2	811	91211	5.19	1	Secretory vesicle membrane;Golgi apparatus membrane	NA	Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity).	NA	Belongs to the peptidase M13 family.	Peptide ligand-binding receptors	PE1	3
+NX_P0DPD7	EEF1A lysine methyltransferase 4	255	28306	5.65	0	NA	NA	Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2).	NA	Belongs to the methyltransferase superfamily.	NA	PE1	3
+NX_P0DPD8	EEF1AKMT4-ECE2 readthrough transcript protein	883	99773	4.98	1	Secretory vesicle membrane;Golgi apparatus membrane	NA	Converts big endothelin-1 to endothelin-1. May also have methyltransferase activity (By similarity). May play a role in amyloid-beta processing (By similarity).	NA	In the N-terminal section; belongs to the methyltransferase superfamily.;In the C-terminal section; belongs to the peptidase M13 family.	NA	PE1	3
+NX_P0DPE3	Transmembrane and death domain protein 1	317	33577	9.29	1	Membrane	NA	NA	NA	NA	NA	PE2	12
+NX_P0DPE8	Small integral membrane protein 34B	139	15007	8.6	1	Membrane	NA	NA	NA	NA	NA	PE2	21
+NX_P0DPF2	Neuroblastoma breakpoint family member 20	5207	595733	4.55	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE2	1
+NX_P0DPF3	Neuroblastoma breakpoint family member 9	1111	127756	4.71	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE2	1
+NX_P0DPF4	T cell receptor alpha variable 35	110	12305	4.64	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE3	14
+NX_P0DPF5	Uncharacterized protein C2orf27A	203	21517	5.13	0	NA	NA	NA	NA	NA	NA	PE2	2
+NX_P0DPF6	Uncharacterized protein C2orf27B	209	22074	4.78	0	NA	NA	NA	NA	NA	NA	PE2	2
+NX_P0DPF7	T cell receptor beta variable 6-3	114	12525	8.38	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE1	7
+NX_P0DPH7	Tubulin alpha-3C chain	450	49960	4.98	0	Cytoskeleton	NA	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.;Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.;Tubulin alpha-1B chain: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules (PubMed:26972003). In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Nitration of Tyr-450 is irreversible and interferes with normal dynein intracellular distribution.;Detyrosinated tubulin alpha-1C chain: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).;Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.	Belongs to the tubulin family.	Separation of Sister Chromatids;MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	13
+NX_P0DPH8	Tubulin alpha-3D chain	450	49960	4.98	0	Cytoskeleton	Keratoconus 9	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.;Detyrosinated tubulin alpha-1C chain: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).;Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.;Nitration of Tyr-450 is irreversible and interferes with normal dynein intracellular distribution.;Tubulin alpha-1B chain: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules (PubMed:26972003). In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).	Belongs to the tubulin family.	Separation of Sister Chromatids;MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	2
+NX_P0DPH9	Uncharacterized protein CXorf51B	108	12028	10.8	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_P0DPI2	Glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial	268	28170	8.5	0	Mitochondrion	NA	NA	NA	Belongs to the GATD3 family.	NA	PE1	21
+NX_P0DPI3	Centromere protein V-like protein 2	272	29887	10.16	0	NA	NA	NA	NA	Belongs to the Gfa family.	NA	PE2	X
+NX_P0DPI4	T cell receptor beta diversity 1	4	290	5.53	0	Cell membrane	NA	D region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).	NA	NA	NA	PE4	7
+NX_P0DPK2	Histone H3.Y	136	15423	11.51	0	Nucleus;Chromosome	NA	Primate-specific variant histone H3, which constitutes a core component of nucleosomes (PubMed:20819935, PubMed:27016736). Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flexible DNA ends, suggesting that they form relaxed chromatin that allows transcription factor access (PubMed:27016736). Histone H1 binds less efficiently to histone H3.Y-containing nucleosomes (PubMed:27016736). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (Probable).	Lysine deamination at Lys-5 (H3K4all) to form allysine. Allysine formation only takes place on H3K4me3 and results in gene repression.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).;Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.;Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.;Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) impairs methylation and represses transcription.;Phosphorylation at Thr-7 (H3T6ph) is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase. Phosphorylation at Thr-12 (H3T11ph) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me). Phosphorylation at Tyr-42 (H3Y41ph) promotes exclusion of CBX5 (HP1 alpha) from chromatin.;Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent acetylation of H3 and H4.	Belongs to the histone H3 family.	NA	PE1	5
+NX_P0DPK3	Notch homolog 2 N-terminal-like protein B	275	30097	5.44	0	Secreted	NA	Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955).	NA	Belongs to the NOTCH family.	NA	PE1	1
+NX_P0DPK4	Notch homolog 2 N-terminal-like protein C	236	25835	5.44	0	Secreted	NA	Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).	NA	Belongs to the NOTCH family.	NA	PE1	1
+NX_P0DPK5	Putative histone H3.X	147	16466	11.39	0	Nucleus;Chromosome	NA	Primate-specific variant histone H3, which constitutes a core component of nucleosomes (PubMed:20819935). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (Probable).	Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).;Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.;Phosphorylation at Thr-7 (H3T6ph) is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase. Phosphorylation at Thr-12 (H3T11ph) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me). Phosphorylation at Tyr-42 (H3Y41ph) promotes exclusion of CBX5 (HP1 alpha) from chromatin.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent acetylation of H3 and H4.;Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.;Lysine deamination at Lys-5 (H3K4all) to form allysine. Allysine formation only takes place on H3K4me3 and results in gene repression.;Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) impairs methylation and represses transcription.	Belongs to the histone H3 family.	NA	PE5	5
+NX_P0DPP9	Embryonic testis differentiation protein homolog B	59	6991	10.43	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_P0DPQ3	Proline-rich protein 20G	210	21866	9.5	0	NA	NA	NA	NA	Belongs to the PRR20 family.	NA	PE3	3
+NX_P0DPQ4	Protein FAM243B	251	29214	8.7	0	NA	NA	NA	NA	Belongs to the FAM243 family.	NA	PE2	21
+NX_P0DPQ6	DDIT3 upstream open reading frame protein	34	4284	11.44	0	Cytoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	12
+NX_P0DPR3	T cell receptor delta diversity 1	2	260	4	0	Cell membrane	NA	D region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	14
+NX_P0DQD5	Neuropeptide Y receptor type 4-2	375	42195	8.46	7	Cell membrane	NA	Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	10
+NX_P0DTA3	Putative speedy protein E11	265	31441	5.8	0	NA	NA	NA	NA	Belongs to the Speedy/Ringo family.	NA	PE5	7
+NX_P10070	Zinc finger protein GLI2	1586	167783	6.9	0	Cytoplasm;Cilium;Nucleolus;Nucleoplasm;Nucleus	Holoprosencephaly 9;Culler-Jones syndrome	Acts as a transcriptional repressor.;Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856).;Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). Are involved in the smoothened (SHH) signaling pathway (PubMed:18455992).	Phosphorylated in vitro by ULK3. Phosphorylated by DYRK2; this inhibits GLI2 transcription factor activity and promotes proteasomal degradation of GLI2.;Acetylation at Lys-757 inhibits Hh target gene expression, probably by impeding entry into chromatin thus preventing promoter occupancy.	Belongs to the GLI C2H2-type zinc-finger protein family.	Degradation of GLI2 by the proteasome;Hedgehog 'on' state;Hedgehog 'off' state;GLI proteins bind promoters of Hh responsive genes to promote transcription;RUNX2 regulates chondrocyte maturation	PE1	2
+NX_P10071	Transcriptional activator GLI3	1580	169863	7.02	0	Cytoplasm;Cilium;Nucleus	Polydactyly, postaxial A1;Polydactyly, postaxial B;Greig cephalo-poly-syndactyly syndrome;Pallister-Hall syndrome;Polydactyly, preaxial 4	Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.	Transcriptional repressor GLI3R, a C-terminally truncated form, is generated from the full-length GLI3 protein (GLI3FL/GLI3-190) through proteolytic processing. This process requires PKA-primed phosphorylation of GLI3, ubiquitination of GLI3 and the presence of BTRC. GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. GLI3R formation leads to its dissociation from SUFU, allowing it to translocate into the nucleus, and repress Hh target genes. When Hh signaling is initiated, SUFU dissociates from GLI3FL and this has two consequences. First, GLI3R production is halted. Second, free GLI3FL translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Phosphorylated in vitro by ULK3.;Phosphorylated on multiple sites by protein kinase A (PKA) and phosphorylation by PKA primes further phosphorylation by CK1 and GSK3. Phosphorylated by DYRK2 (in vitro). Phosphorylation is essential for its proteolytic processing.	Belongs to the GLI C2H2-type zinc-finger protein family.	GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'off' state;GLI proteins bind promoters of Hh responsive genes to promote transcription;RUNX2 regulates osteoblast differentiation	PE1	7
+NX_P10072	Zinc finger protein 875	659	75128	9.44	0	Nucleoplasm;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_P10073	Zinc finger and SCAN domain-containing protein 22	491	54561	7.36	0	Cytosol;Cytoskeleton;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P10074	Telomere zinc finger-associated protein	688	77054	8.55	0	Nucleoplasm;Cytosol;Telomere;Nucleus	NA	Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_P10075	Zinc finger protein GLI4	376	41145	9.13	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	NA	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_P10082	Peptide YY	97	11145	7.88	0	Secreted	NA	This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.	The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).	Belongs to the NPY family.	G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	17
+NX_P10092	Calcitonin gene-related peptide 2	127	13706	10.1	0	Secreted	NA	CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.	NA	Belongs to the calcitonin family.	G alpha (s) signalling events;Calcitonin-like ligand receptors	PE1	11
+NX_P10109	Adrenodoxin, mitochondrial	184	19393	5.51	0	Mitochondrion matrix;Mitochondrion	NA	Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity).	NA	Belongs to the adrenodoxin/putidaredoxin family.	Mitochondrial iron-sulfur cluster biogenesis;Pregnenolone biosynthesis;Endogenous sterols;Electron transport from NADPH to Ferredoxin;Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	PE1	11
+NX_P10114	Ras-related protein Rap-2a	183	20615	4.73	0	Recycling endosome membrane;Midbody	NA	Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.	Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.;Ubiquitinated; undergoes 'Lys-63' monoubiquitination and diubiquitination by NEDD4. Multiple lysine residues are probably modified. Ubiquitination requires TNIK, prevents interaction with effectors and inactivates RAP2A.	Belongs to the small GTPase superfamily. Ras family.	NA	PE1	13
+NX_P10124	Serglycin	158	17652	4.81	0	Golgi apparatus;Cytoplasmic granule;Extracellular space	NA	Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.	O-glycosylated; contains chondroitin sulfate and heparan sulfate.	Belongs to the serglycin family.	Platelet degranulation	PE1	10
+NX_P10144	Granzyme B	247	27716	9.62	0	Cytoplasmic granule	NA	This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.	NA	Belongs to the peptidase S1 family. Granzyme subfamily.	Natural killer cell mediated cytotoxicity;Type I diabetes mellitus;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;NOTCH2 intracellular domain regulates transcription;Activation, myristolyation of BID and translocation to mitochondria	PE1	14
+NX_P10145	Interleukin-8	99	11098	9.1	0	Secreted	NA	IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.	Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.;Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Salmonella infection;Pertussis;Legionellosis;Chagas disease (American trypanosomiasis);Malaria;Amoebiasis;Hepatitis C;Influenza A;Pathways in cancer;Bladder cancer;Rheumatoid arthritis;G alpha (i) signalling events;Peptide ligand-binding receptors;Senescence-Associated Secretory Phenotype (SASP);Chemokine receptors bind chemokines;ATF4 activates genes in response to endoplasmic reticulum stress;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling	PE1	4
+NX_P10147	C-C motif chemokine 3	92	10085	4.77	0	Secreted	NA	Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).	N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Toll-like receptor signaling pathway;Salmonella infection;Chagas disease (American trypanosomiasis);Rheumatoid arthritis;Interleukin-10 signaling	PE1	17
+NX_P10153	Non-secretory ribonuclease	161	18354	9.1	0	Cytoplasmic granule;Lysosome	NA	This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.	A particular signal processing and glycosylation pattern may differentiate the UpI2 RNase, found specifically in pregnant women urine, from other nonsecretory RNases.	Belongs to the pancreatic ribonuclease family.	Neutrophil degranulation	PE1	14
+NX_P10155	60 kDa SS-A/Ro ribonucleoprotein	538	60671	8.27	0	Cytoplasm;Nucleoplasm;Cytosol	NA	May play roles in cilia formation and/or maintenance.;RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation (PubMed:18056422). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853).	NA	Belongs to the Ro 60 kDa family.	Systemic lupus erythematosus	PE1	1
+NX_P10163	Basic salivary proline-rich protein 4	310	31326	10.52	0	Secreted	NA	NA	N-glycosylated.;Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine. The endoprotease may be of microbial origin. Pyroglutamate formation found on at least Gln-46, Gln-48, Gln-67, Gln-88; Gln-90; Gln-193; Gln-288 Gln-214 and Gln-295, preferentially in diabetic, and head and neck cancer patients.	NA	NA	PE1	12
+NX_P10176	Cytochrome c oxidase subunit 8A, mitochondrial	69	7579	10.26	1	Mitochondrion inner membrane;Mitochondrion	NA	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase VIII family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	11
+NX_P10242	Transcriptional activator Myb	640	72341	6.35	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.	Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.;Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.;Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.;MYB is phosphorylated by HIPK1;MYB is phosphorylated by NLK (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254)	NA	HTLV-I infection;Factors involved in megakaryocyte development and platelet production;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_P10243	Myb-related protein A	752	85887	6.69	0	Nucleoplasm;Nucleus	NA	Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).	MYBL1 is phosphorylated by NLK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	HTLV-I infection;PIWI-interacting RNA (piRNA) biogenesis	PE1	8
+NX_P10244	Myb-related protein B	700	78764	6.43	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.	Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.	NA	HTLV-I infection;Polo-like kinase mediated events;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	PE1	20
+NX_P10253	Lysosomal alpha-glucosidase	952	105324	5.62	0	Lysosome membrane;Lysosome	Glycogen storage disease 2	Essential for the degradation of glycogen in lysosomes (PubMed:1856189, PubMed:7717400, PubMed:14695532, PubMed:18429042). Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans (PubMed:29061980).	Phosphorylation of mannose residues ensures efficient transport of the enzyme to the lysosomes via the mannose 6-phosphate receptor.;The different forms of acid glucosidase are obtained by proteolytic processing.	Belongs to the glycosyl hydrolase 31 family.	Galactose metabolism;Starch and sucrose metabolism;Metabolic pathways;Lysosome;Glycogen breakdown (glycogenolysis);Glycogen storage disease type II (GAA);Neutrophil degranulation	PE1	17
+NX_P10265	Endogenous retrovirus group K member 10 Pro protein	156	17108	5.86	0	NA	NA	Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases.	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein.	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE1	5
+NX_P10266	Endogenous retrovirus group K member 10 Pol protein	1014	114827	9.11	0	NA	NA	Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	NA	Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.	NA	PE3	5
+NX_P10275	Androgen receptor	920	99188	6.01	0	Cytoplasm;Mitochondrion;Nucleus	Spinal and bulbar muscular atrophy X-linked 1;Androgen insensitivity syndrome;Hypospadias 1, X-linked;Androgen insensitivity, partial	Lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.;Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-535 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression. Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity and may be responsible for androgen-independent progression of prostate cancer. Phosphorylation at Ser-83 by CDK9 regulates AR promoter selectivity and cell growth. Phosphorylation by PAK6 leads to AR-mediated transcription inhibition.;Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.;Sumoylated on Lys-388 (major) and Lys-521. Ubiquitinated. Deubiquitinated by USP26. 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity.;AR is phosphorylated by GSK3B;AR is phosphorylated by PAK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the nuclear hormone receptor family. NR3 subfamily.	Oocyte meiosis;Pathways in cancer;Prostate cancer;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Nuclear Receptor transcription pathway;Ub-specific processing proteases;HSP90 chaperone cycle for steroid hormone receptors (SHR);RUNX2 regulates osteoblast differentiation;SUMOylation of intracellular receptors	PE1	X
+NX_P10276	Retinoic acid receptor alpha	462	50771	8.21	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Receptor for retinoic acid (PubMed:19850744, PubMed:16417524, PubMed:20215566). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:9267036, PubMed:19850744, PubMed:20215566). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758).	Phosphorylated on serine and threonine residues. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity (By similarity). Phosphorylation by AKT1 is required for the repressor activity but has no effect on DNA binding, protein stability nor subcellular localization. Phosphorylated by PKA in vitro. This phosphorylation on Ser-219 and Ser-369 is critical for ligand binding, nuclear localization and transcriptional activity in response to FSH signaling.;Ubiquitinated.;Trimethylation enhances heterodimerization with RXRA and positively modulates the transcriptional activation.;Sumoylated with SUMO2, mainly on Lys-399 which is also required for SENP6 binding. On all-trans retinoic acid (ATRA) binding, a confromational change may occur that allows sumoylation on two additional site, Lys-166 and Lys-171. Probably desumoylated by SENP6. Sumoylation levels determine nuclear localization and regulate ATRA-mediated transcriptional activity.;Acetylated; acetylation is increased upon pulsatile shear stress and decreased upon oscillatory shear stress.	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Pathways in cancer;Acute myeloid leukemia;Nuclear Receptor transcription pathway;Signaling by Retinoic Acid;Activation of anterior HOX genes in hindbrain development during early embryogenesis;SUMOylation of intracellular receptors;Transcriptional regulation of granulopoiesis	PE1	17
+NX_P10301	Ras-related protein R-Ras	218	23480	6.43	0	Cytoplasmic vesicle;Cell membrane	NA	Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).	NA	Belongs to the small GTPase superfamily. Ras family.	MAPK signaling pathway;Tight junction;Regulation of actin cytoskeleton;HTLV-I infection;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Sema4D mediated inhibition of cell attachment and migration	PE1	19
+NX_P10321	HLA class I histocompatibility antigen, C alpha chain	366	40649	5.71	1	Endoplasmic reticulum membrane;Cell membrane	Psoriasis 1	ALLELE C*06:02: In trophoblasts, interacts with KIR2DS2 on uterine NK cells and triggers NK cell activation, including secretion of cytokines such as GMCSF that enhances trophoblast migration.;ALLELE C*07:02: Plays an important role in the control of chronic CMV infection. Presents immunodominant CMV epitopes derived from IE1 (LSEFCRVL and CRVLCCYVL) and UL28 (FRCPRRFCF), both antigens synthesized during immediate-early period of viral replication. Elicits a strong anti-viral CD8-positive T cell immune response that increases markedly with age.;ALLELE C*01:02: The peptide-bound form interacts with KIR2DL2 and KIR2DL3 inhibitory receptors on NK cells. The low affinity peptides compete with the high affinity peptides impeding KIR-mediated inhibition and favoring lysis of infected cells (PubMed:20439706). Presents to CD8-positive T cells a CMV epitope derived from UL83/pp65 (RCPEMISVL), an immediate-early antigen necessary for initiating viral replication (PubMed:12947002).;ALLELE C*04:01: Presents a conserved HIV-1 epitope derived from env (SFNCGGEFF) to memory CD8-positive T cells, eliciting very strong IFNG responses (PubMed:20104487). Presents CMV epitope derived from UL83/pp65 (QYDPVAALF) to CD8-positive T cells, triggering T cell cytotoxic response (PubMed:12947002).;ALLELE C*12:02: Presents CMV epitope derived from UL83 (VAFTSHEHF) to CD8-positive T cells.;Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity (PubMed:20972337, PubMed:24091323, PubMed:20439706, PubMed:11172028, PubMed:20104487, PubMed:28649982, PubMed:29312307). In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells (PubMed:16141329). In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary for placentation and overall fetal growth (PubMed:20972337, PubMed:24091323). During viral infection, may present viral peptides with low affinity for KIRs, impeding KIR-mediated inhibition through peptide antagonism and favoring lysis of infected cells (PubMed:20439706). Presents a restricted repertoire of viral peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-C-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected cells, particularly in chronic viral infection settings such as HIV-1 or CMV infection (PubMed:11172028, PubMed:20104487, PubMed:28649982). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (By similarity). Typically presents intracellular peptide antigens of 9 amino acids that arise from cytosolic proteolysis via proteasome. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9. Preferentially displays peptides having a restricted repertoire of hydrophobic or aromatic amino acids (Phe, Ile, Leu, Met, Val and Tyr) at the C-terminal anchor (PubMed:8265661, PubMed:25311805).;ALLELE C*05:01: Presents HIV-1 epitope derived from rev (SAEPVPLQL) to CD8-positive T cells, triggering T cell cytotoxic response.;ALLELE C*08:01: Presents viral epitopes derived from CMV UL83 (VVCAHELVC) and IAV M1 (GILGFVFTL), triggering CD8-positive T cell cytotoxic response.;ALLELE C*15:02: Presents CMV epitope derived from UL83 CC (VVCAHELVC) to CD8-positive T cells, triggering T cell cytotoxic response.	N-linked glycosylation at Asn-110 is required for efficient interaction with CANX and CALR chaperones and appropriate HLA-C-B2M folded conformers prior to peptide loading.	NA	Endocytosis;Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Type I diabetes mellitus;HTLV-I infection;Herpes simplex infection;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;Viral myocarditis;ER-Phagosome pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Endosomal/Vacuolar pathway;Interferon gamma signaling;Interferon alpha/beta signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Neutrophil degranulation	PE1	6
+NX_P10323	Acrosin	421	45847	9.26	0	NA	NA	Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.	NA	Belongs to the peptidase S1 family.	Acrosome Reaction and Sperm:Oocyte Membrane Binding	PE1	22
+NX_P10398	Serine/threonine-protein kinase A-Raf	606	67585	9.2	0	Nucleoplasm;Nucleolus	NA	Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.;Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.	NA	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.	ErbB signaling pathway;Vascular smooth muscle contraction;Natural killer cell mediated cytotoxicity;Long-term potentiation;Long-term depression;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Hepatitis C;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Negative regulation of MAPK pathway;RAF activation;MAP2K and MAPK activation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	X
+NX_P10412	Histone H1.4	219	21865	11.03	0	Nucleus speckle;Nucleus;Chromosome	Rahman syndrome	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).	ADP-ribosylated on Ser-150 in response to DNA damage.;H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.;Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1.;Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.	Belongs to the histone H1/H5 family.	Formation of Senescence-Associated Heterochromatin Foci (SAHF);Apoptosis induced DNA fragmentation	PE1	6
+NX_P10415	Apoptosis regulator Bcl-2	239	26266	6.75	1	Mitochondrion outer membrane;Nucleoplasm;Endoplasmic reticulum membrane;Nucleus membrane	NA	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).	Monoubiquitinated by PRKN, leading to increase its stability. Ubiquitinated by SCF(FBXO10), leading to its degradation by the proteasome.;Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity.;Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).	Belongs to the Bcl-2 family.	Protein processing in endoplasmic reticulum;Apoptosis;Focal adhesion;Neurotrophin signaling pathway;Cholinergic synapse;Amyotrophic lateral sclerosis (ALS);Toxoplasmosis;Tuberculosis;Pathways in cancer;Colorectal cancer;Prostate cancer;Small cell lung cancer;Activation of BAD and translocation to mitochondria;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;The NLRP1 inflammasome;Interleukin-4 and Interleukin-13 signaling;Estrogen-dependent gene expression;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	18
+NX_P10451	Osteopontin	314	35423	4.37	0	Golgi apparatus;Secreted	NA	Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.;Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.	O-glycosylated.;Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif.;Is GalNAc O-glycosylated at Thr-59 or Ser-62.	Belongs to the osteopontin family.	Focal adhesion;ECM-receptor interaction;Toll-like receptor signaling pathway;Degradation of the extracellular matrix;Signaling by PDGF;Integrin cell surface interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;RUNX3 Regulates Immune Response and Cell Migration	PE1	4
+NX_P10515	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	647	68997	7.96	0	Mitochondrion matrix;Mitochondrion	Pyruvate dehydrogenase E2 deficiency	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.	Delipoylated at Lys-132 and Lys-259 by SIRT4, delipoylation decreases the PHD complex activity.	Belongs to the 2-oxoacid dehydrogenase family.	Glycolysis / Gluconeogenesis;Citrate cycle (TCA cycle);Pyruvate metabolism;Metabolic pathways;Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex;Pyruvate metabolism;Glyoxylate metabolism and glycine degradation	PE1	11
+NX_P10523	S-arrestin	405	45120	6.14	0	Membrane;Photoreceptor outer segment	Night blindness, congenital stationary, Oguchi type 1;Retinitis pigmentosa 47	Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049).	NA	Belongs to the arrestin family.	Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade	PE1	2
+NX_P10586	Receptor-type tyrosine-protein phosphatase F	1907	212879	5.92	1	Membrane;Golgi apparatus	Aplasia or hypoplasia of the breasts and/or nipples 2	Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.;The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.	NA	Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.	Cell adhesion molecules (CAMs);Adherens junction;Insulin signaling pathway;Synaptic adhesion-like molecules;Receptor-type tyrosine-protein phosphatases	PE1	1
+NX_P10588	Nuclear receptor subfamily 2 group F member 6	404	42979	7.96	0	Nucleus	NA	Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).	NA	Belongs to the nuclear hormone receptor family. NR2 subfamily.	Nuclear Receptor transcription pathway	PE1	19
+NX_P10589	COUP transcription factor 1	423	46156	8.62	0	Nucleus	Bosch-Boonstra-Schaaf optic atrophy syndrome	Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.	NA	Belongs to the nuclear hormone receptor family. NR2 subfamily.	Nuclear Receptor transcription pathway	PE1	5
+NX_P10599	Thioredoxin	105	11737	4.82	0	Cytoplasm;Secreted;Nucleoplasm;Cytosol;Nucleus	NA	Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.;ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).	In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins.;In case of infection, ubiquitinated by S.typhimurium protein slrP, leading to its degradation.	Belongs to the thioredoxin family.	Detoxification of Reactive Oxygen Species;Oxidative Stress Induced Senescence;The NLRP3 inflammasome;TP53 Regulates Metabolic Genes;Interconversion of nucleotide di- and triphosphates;Protein repair;Regulation of FOXO transcriptional activity by acetylation	PE1	9
+NX_P10600	Transforming growth factor beta-3 proprotein	412	47328	8.31	0	Cytoplasmic vesicle;Extracellular matrix;Secreted	Loeys-Dietz syndrome 5;Arrhythmogenic right ventricular dysplasia, familial, 1	Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.;Latency-associated peptide: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity).;Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).	Transforming growth factor beta-3 proprotein: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-3 (TGF-beta-3) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-3 inactive.;Methylated at Gln-293 by N6AMT1.	Belongs to the TGF-beta family.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Cell cycle;Endocytosis;TGF-beta signaling pathway;Leishmaniasis;Chagas disease (American trypanosomiasis);Malaria;Toxoplasmosis;Amoebiasis;Tuberculosis;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Chronic myeloid leukemia;Rheumatoid arthritis;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Platelet degranulation;ECM proteoglycans;Molecules associated with elastic fibres	PE1	14
+NX_P10606	Cytochrome c oxidase subunit 5B, mitochondrial	129	13696	9.07	0	Mitochondrion inner membrane;Mitochondrion	NA	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase subunit 5B family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	2
+NX_P10619	Lysosomal protective protein	480	54466	6.16	0	Cytoplasmic vesicle;Lysosome	Galactosialidosis	Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.	NA	Belongs to the peptidase S10 family.	Lysosome;Renin-angiotensin system;MHC class II antigen presentation;Sialic acid metabolism;Glycosphingolipid metabolism;Defective NEU1 causes sialidosis;Neutrophil degranulation	PE1	20
+NX_P10620	Microsomal glutathione S-transferase 1	155	17599	9.41	4	Mitochondrion outer membrane;Endoplasmic reticulum membrane;Mitochondrion;Microsome;Endoplasmic reticulum	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.	Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.	Belongs to the MAPEG family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation;Aflatoxin activation and detoxification;Neutrophil degranulation	PE1	12
+NX_P10632	Cytochrome P450 2C8	490	55825	8.8	0	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond (PubMed:7574697, PubMed:15766564, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form (PubMed:11093772). Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1) (PubMed:14559847). Plays a role in the oxidative metabolism of xenobiotics. It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol) (PubMed:26427316).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; arachidonate metabolism.;Cofactor metabolism; retinol metabolism.;Steroid metabolism.;Arachidonic acid metabolism;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Xenobiotics;Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET);CYP2E1 reactions;Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE);Biosynthesis of maresin-like SPMs	PE1	10
+NX_P10635	Cytochrome P450 2D6	497	55769	6.77	0	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:19965576, PubMed:20972997). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:18698000, PubMed:21289075). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid (PubMed:10681376). Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.	NA	Belongs to the cytochrome P450 family.	Cofactor metabolism; retinol metabolism.;Lipid metabolism; fatty acid metabolism.;Steroid metabolism; cholesterol metabolism.;Miscellaneous substrates;Xenobiotics;Fatty acids;CYP2E1 reactions;Biosynthesis of maresin-like SPMs	PE1	22
+NX_P10636	Microtubule-associated protein tau	758	78928	6.25	0	Nucleus speckle;Cell membrane;Cytosol;Axon;Dendrite;Cytoskeleton	Parkinson-dementia syndrome;Pick disease of the brain;Frontotemporal dementia;Progressive supranuclear palsy 1	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.	Glycation of PHF-tau, but not normal brain TAU/MAPT. Glycation is a non-enzymatic post-translational modification that involves a covalent linkage between a sugar and an amino group of a protein molecule forming ketoamine. Subsequent oxidation, fragmentation and/or cross-linking of ketoamine leads to the production of advanced glycation endproducts (AGES). Glycation may play a role in stabilizing PHF aggregation leading to tangle formation in AD.;O-glycosylated. O-GlcNAcylation content is around 8.2%. There is reciprocal down-regulation of phosphorylation and O-GlcNAcylation. Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces O-GlcNAcylation by a factor of 2 and 4 respectively. O-GlcNAcylation on Ser-717 decreases the phosphorylation on Ser-721 by about 41.5%.;Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By similarity). PHF-tau can be modified by three different forms of polyubiquitination. 'Lys-48'-linked polyubiquitination is the major form, 'Lys-6'-linked and 'Lys-11'-linked polyubiquitination also occur.;Phosphorylation at serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1, CDK1, CDK5, GSK3, MAPK) (only 2-3 sites per protein in interphase, seven-fold increase in mitosis, and in the form associated with paired helical filaments (PHF-tau)), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1, MARK2, MARK3 or MARK4), causing detachment from microtubules, and their disassembly (PubMed:7706316, PubMed:23666762). Phosphorylation decreases with age. Phosphorylation within tau/MAP's repeat domain or in flanking regions seems to reduce tau/MAP's interaction with, respectively, microtubules or plasma membrane components (PubMed:7706316). Phosphorylation on Ser-610, Ser-622, Ser-641 and Ser-673 in several isoforms during mitosis. Phosphorylation at Ser-548 by GSK3B reduces ability to bind and stabilize microtubules. Phosphorylation at Ser-579 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylated at Ser-554, Ser-579, Ser-602, Ser-606 and Ser-669 by PHK. Phosphorylation at Ser-214 by SGK1 mediates microtubule depolymerization and neurite formation in hippocampal neurons. There is a reciprocal down-regulation of phosphorylation and O-GlcNAcylation. Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces glycosylation by a factor of 2 and 4 respectively. Phosphorylation on Ser-721 is reduced by about 41.5% by GlcNAcylation on Ser-717. Dephosphorylated at several serine and threonine residues by the serine/threonine phosphatase PPP5C.;MAPT is phosphorylated by PKN1 (Phosphoserine:PTM-0253);MAPT is phosphorylated by LCK (Phosphotyrosine:PTM-0255)	NA	MAPK signaling pathway;Alzheimer's disease;Caspase-mediated cleavage of cytoskeletal proteins;Activation of AMPK downstream of NMDARs	PE1	17
+NX_P10643	Complement component C7	843	93518	6.09	0	Secreted	Complement component 7 deficiency	Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.	C7 has 28 disulfide bridges.;C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.	Belongs to the complement C6/C7/C8/C9 family.	Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus;Terminal pathway of complement;Regulation of Complement cascade	PE1	5
+NX_P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	381	42982	5.27	0	Cytosol;Cell membrane	Acrodysostosis 1, with or without hormone resistance;Intracardiac myxoma;Carney complex 1;Primary pigmented nodular adrenocortical disease 1	Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.	The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.	Belongs to the cAMP-dependent kinase regulatory chain family.	Apoptosis;Insulin signaling pathway;Factors involved in megakaryocyte development and platelet production;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase	PE1	17
+NX_P10645	Chromogranin-A	457	50688	4.58	0	Secretory vesicle lumen;Secreted;Secretory vesicle membrane;Cytoplasmic vesicle;Secretory vesicle	NA	Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.;Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522).;Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.	Sulfated on tyrosine residues and/or contains sulfated glycans.;Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity (PubMed:10781584). Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides (PubMed:17991725).;O-glycosylated with core 1 or possibly core 8 glycans.	Belongs to the chromogranin/secretogranin protein family.	Antimicrobial peptides	PE1	14
+NX_P10646	Tissue factor pathway inhibitor	304	35015	8.61	0	Microsome membrane;Cytosol;Secreted;Cytoskeleton	NA	Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.	O-glycosylated.	NA	Complement and coagulation cascades;Extrinsic Pathway of Fibrin Clot Formation	PE1	2
+NX_P10696	Alkaline phosphatase, germ cell type	532	57377	5.9	0	Cell membrane	NA	NA	NA	Belongs to the alkaline phosphatase family.	Folate biosynthesis;Metabolic pathways;Post-translational modification: synthesis of GPI-anchored proteins	PE1	2
+NX_P10720	Platelet factor 4 variant	104	11553	9.3	0	Secreted	NA	Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro).	The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most abundant form is Platelet factor 4 variant(5-74).	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall	PE1	4
+NX_P10721	Mast/stem cell growth factor receptor Kit	976	109865	6.54	1	Cytoplasm;Cell membrane	Mastocytosis, systemic;Piebald trait;Gastrointestinal stromal tumor;Mastocytosis, cutaneous;Testicular germ cell tumor;Leukemia, acute myelogenous	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.	Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation.;Autophosphorylated on tyrosine residues. KITLG/SCF binding enhances autophosphorylation.;Shows low levels of tyrosine phosphorylation in the absence of added KITLG/SCF (in vitro). Kinase activity is down-regulated by phosphorylation on serine residues by protein kinase C family members. Phosphorylation at Tyr-568 is required for interaction with PTPN11/SHP-2, CRK (isoform Crk-II) and members of the SRC tyrosine-protein kinase family. Phosphorylation at Tyr-570 is required for interaction with PTPN6/SHP-1. Phosphorylation at Tyr-703, Tyr-823 and Tyr-936 is important for interaction with GRB2. Phosphorylation at Tyr-721 is important for interaction with PIK3R1. Phosphorylation at Tyr-823 and Tyr-936 is important for interaction with GRB7.;KIT is phosphorylated by LYN (Phosphotyrosine:PTM-0255);Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Cytokine-cytokine receptor interaction;Endocytosis;Hematopoietic cell lineage;Melanogenesis;Pathways in cancer;Acute myeloid leukemia;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Signaling by SCF-KIT;Regulation of KIT signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	PE1	4
+NX_P10745	Retinol-binding protein 3	1247	135363	4.98	0	Interphotoreceptor matrix	Retinitis pigmentosa 66	IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.	NA	Belongs to the peptidase S41A family.	The canonical retinoid cycle in rods (twilight vision);The retinoid cycle in cones (daylight vision)	PE1	10
+NX_P10746	Uroporphyrinogen-III synthase	265	28628	5.35	0	Nucleoplasm;Cytosol	Congenital erythropoietic porphyria	Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).	NA	Belongs to the uroporphyrinogen-III synthase family.	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.;Porphyrin and chlorophyll metabolism;Metabolic pathways;Heme biosynthesis	PE1	10
+NX_P10747	T-cell-specific surface glycoprotein CD28	220	25066	9.46	1	Cell surface;Membrane	NA	Enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).;Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933).	CD40LG induces tyrosine phosphorylation of isoform 3.;CD28 is phosphorylated by FYN (Phosphotyrosine:PTM-0255);CD28 is phosphorylated by ITK (Phosphotyrosine:PTM-0255)	NA	Cell adhesion molecules (CAMs);T cell receptor signaling pathway;Intestinal immune network for IgA production;Type I diabetes mellitus;Measles;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;CD28 dependent PI3K/Akt signaling;Nef mediated downregulation of CD28 cell surface expression;CD28 co-stimulation;CD28 dependent Vav1 pathway;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	2
+NX_P10767	Fibroblast growth factor 6	208	22905	10	0	Extracellular space	NA	Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR1;FGFR4 ligand binding and activation;FGFR1c ligand binding and activation;FGFR2c ligand binding and activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR4;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1	PE1	12
+NX_P10768	S-formylglutathione hydrolase	282	31463	6.54	0	Golgi apparatus;Cytoplasm;Cytosol;Cytoplasmic vesicle	NA	Serine hydrolase involved in the detoxification of formaldehyde.	NA	Belongs to the esterase D family.	Glutathione conjugation	PE1	13
+NX_P10809	60 kDa heat shock protein, mitochondrial	573	61055	5.7	0	Mitochondrion matrix;Mitochondrion	Spastic paraplegia 13, autosomal dominant;Leukodystrophy, hypomyelinating, 4	Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).	NA	Belongs to the chaperonin (HSP60) family.	RNA degradation;Type I diabetes mellitus;Legionellosis;Tuberculosis;Mitochondrial protein import;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	PE1	2
+NX_P10826	Retinoic acid receptor beta	455	50489	8.04	0	Cytoplasm;Nucleoplasm;Nucleus	Microphthalmia, syndromic, 12	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed:12554770). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed:29021580). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).	NA	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Pathways in cancer;Small cell lung cancer;Non-small cell lung cancer;Nuclear Receptor transcription pathway;Signaling by Retinoic Acid;Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	3
+NX_P10827	Thyroid hormone receptor alpha	490	54816	6.42	0	Cytoplasm;Cytosol;Nucleus	Hypothyroidism, congenital, non-goitrous, 6	Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.;Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.	NA	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Neuroactive ligand-receptor interaction;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors	PE1	17
+NX_P10828	Thyroid hormone receptor beta	461	52788	6.68	0	Nucleus	Generalized thyroid hormone resistance autosomal recessive;Generalized thyroid hormone resistance;Selective pituitary thyroid hormone resistance	Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.	NA	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Neuroactive ligand-receptor interaction;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors	PE1	3
+NX_P10909	Clusterin	449	52495	5.89	0	Cytoplasm;Mitochondrion;Microsome;Secreted;Endoplasmic reticulum;Mitochondrion membrane;Cytosol;Perinuclear region;Chromaffin granule;Nucleus	NA	Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed:21567405).;Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity.;Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:17260971, PubMed:19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed:12047389, PubMed:17412999, PubMed:17407782). Does not require ATP (PubMed:11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed:11123922). Does not refold proteins by itself (PubMed:11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed:21505792). Protects cells against apoptosis and against cytolysis by complement (PubMed:2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed:20068069). Modulates NF-kappa-B transcriptional activity (PubMed:12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed:16113678, PubMed:17689225). Plays a role in the regulation of cell proliferation (PubMed:19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed:22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity).	Proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen (PubMed:2387851). Proteolytic cleavage is not necessary for its chaperone activity (PubMed:25402950). All non-secreted forms are not proteolytically cleaved (PubMed:24073260). Chaperone activity of uncleaved forms is dependent on a non-reducing envoronment (PubMed:25402950).;Extensively glycosylated with sulfated N-linked carbohydrates (PubMed:17260971, PubMed:2387851). About 30% of the protein mass is comprised of complex N-linked carbohydrate (PubMed:2387851). Endoplasmic reticulum (ER) stress induces changes in glycosylation status and increases level of hypoglycosylated forms (PubMed:22689054). Core carbohydrates are essential for chaperone activity (PubMed:25402950). Non-secreted forms are hypoglycosylated or unglycosylated (PubMed:24073260).;Polyubiquitinated, leading to proteasomal degradation (PubMed:17451556, PubMed:19137541). Under cellular stress, the intracellular level of cleaved form is reduced due to proteasomal degradation (PubMed:17451556).	Belongs to the clusterin family.	Terminal pathway of complement;Regulation of Complement cascade;Platelet degranulation;Antimicrobial peptides	PE1	8
+NX_P10911	Proto-oncogene DBL	925	107673	5.72	0	Membrane;Cytoplasm	NA	Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form.;Exhibits decreased GEF activity toward CDC42.;Exhibits no activity toward RHOA, RAC1 or CDC42.;Exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.;Exhibits a weak but significant activity toward RAC1 and CDC42.	Phosphorylation by TNK2 enhances guanine nucleotide exchange factor (GEF) activity toward Rho family proteins.;MCF2 is phosphorylated by TNK2 (Phosphotyrosine:PTM-0255)	Belongs to the MCF2 family.	Axonal growth inhibition (RHOA activation);Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	X
+NX_P10912	Growth hormone receptor	638	71500	4.76	1	Cytosol;Secreted;Cell membrane	Growth hormone insensitivity, partial;Laron syndrome	Up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.;The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.;Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).	On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).;The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17 (By similarity).;On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.;GHR is phosphorylated by JAK2	Belongs to the type I cytokine receptor family. Type 1 subfamily.	Cytokine-cytokine receptor interaction;Neuroactive ligand-receptor interaction;Jak-STAT signaling pathway;Prolactin receptor signaling;Growth hormone receptor signaling	PE1	5
+NX_P10914	Interferon regulatory factor 1	325	36502	5.22	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Gastric cancer	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.	Phosphorylated by CK2 and this positively regulates its activity.;Ubiquitinated. Appears to compete with sumoylation on C-terminal sites.;Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-275. Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites.;IRF1 is phosphorylated by CHUK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the IRF family.	Pertussis;Hepatitis C;Factors involved in megakaryocyte development and platelet production;Interferon gamma signaling;Interferon alpha/beta signaling	PE1	5
+NX_P10915	Hyaluronan and proteoglycan link protein 1	354	40166	7.1	0	Cytoplasmic vesicle;Extracellular matrix	NA	Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.	NA	Belongs to the HAPLN family.	ECM proteoglycans	PE1	5
+NX_P10916	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform	166	18789	4.92	0	A band;Cytoskeleton	Cardiomyopathy, familial hypertrophic 10	Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).	N-terminus is methylated by METTL11A/NTM1.;Phosphorylated by MYLK3 and MYLK2; promotes cardiac muscle contraction and function (By similarity). Dephosphorylated by PPP1CB complexed to PPP1R12B (By similarity). The phosphorylated form in adult is expressed as gradients across the heart from endocardium (low phosphorylation) to epicardium (high phosphorylation); regulates cardiac torsion and workload distribution (By similarity).;MYL2 is phosphorylated by DAPK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Cardiac muscle contraction;Focal adhesion;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Striated Muscle Contraction	PE1	12
+NX_P10966	T-cell surface glycoprotein CD8 beta chain	210	23722	10.03	1	Secreted;Cell membrane	NA	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.	Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.;Phosphorylated as a consequence of T-cell activation.	NA	Cell adhesion molecules (CAMs);Antigen processing and presentation;Hematopoietic cell lineage;T cell receptor signaling pathway;Primary immunodeficiency;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Nef Mediated CD8 Down-regulation	PE1	2
+NX_P10997	Islet amyloid polypeptide	89	9806	9.83	0	Secreted	NA	Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.	Amyloid fibrils are degraded by IDE.	Belongs to the calcitonin family.	Maturity onset diabetes of the young;G alpha (s) signalling events;Regulation of gene expression in beta cells;Amyloid fiber formation;Calcitonin-like ligand receptors	PE1	12
+NX_P11021	Endoplasmic reticulum chaperone BiP	654	72333	5.07	0	Cytoplasm;Cytosol;Endoplasmic reticulum lumen;Melanosome	NA	Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating.	AMPylated by FICD (PubMed:25601083). In unstressed cells, AMPylation at Thr-518 by FICD inactivates the chaperome activity: AMPylated form is locked in a relatively inert state and only weakly stimulated by J domain-containing proteins (By similarity). In response to endoplasmic reticulum stress, de-AMPylation by the same protein, FICD, restores the chaperone activity (By similarity).	Belongs to the heat shock protein 70 family.	Protein export;Protein processing in endoplasmic reticulum;Antigen processing and presentation;Prion diseases;Regulation of HSF1-mediated heat shock response;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Platelet degranulation;ATF6 (ATF6-alpha) activates chaperones;PERK regulates gene expression;IRE1alpha activates chaperones;ATF6 (ATF6-alpha) activates chaperone genes	PE1	9
+NX_P11047	Laminin subunit gamma-1	1609	177603	5.01	0	Endoplasmic reticulum;Basement membrane;Cell membrane	NA	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	NA	NA	Focal adhesion;ECM-receptor interaction;Prion diseases;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer;Degradation of the extracellular matrix;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Non-integrin membrane-ECM interactions;L1CAM interactions;Laminin interactions;MET activates PTK2 signaling;Post-translational protein phosphorylation	PE1	1
+NX_P11049	Leukocyte antigen CD37	281	31703	8.25	4	Membrane	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	Hematopoietic cell lineage	PE1	19
+NX_P11055	Myosin-3	1940	223905	5.62	0	Myofibril	Arthrogryposis, distal, 2A;Contractures, pterygia, and variable skeletal fusions syndrome 1A;Contractures, pterygia, and variable skeletal fusions syndrome 1B;Arthrogryposis, distal, 2B3	Muscle contraction.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tight junction;Viral myocarditis;Striated Muscle Contraction	PE1	17
+NX_P11086	Phenylethanolamine N-methyltransferase	282	30855	5.73	0	NA	NA	Converts noradrenaline to adrenaline.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.	Catecholamine biosynthesis; (R)-adrenaline biosynthesis; (R)-adrenaline from (R)-noradrenaline: step 1/1.;Tyrosine metabolism;Metabolic pathways;Catecholamine biosynthesis	PE1	17
+NX_P11117	Lysosomal acid phosphatase	423	48344	6.28	1	Lysosome membrane;Lysosome lumen	NA	NA	N-glycosylated. The intermediates formed during enzymatic deglycosylation suggest that all eight predicted N-glycosylation sites are used.;The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen.	Belongs to the histidine acid phosphatase family.	Riboflavin metabolism;Lysosome	PE1	11
+NX_P11137	Microtubule-associated protein 2	1827	199526	4.82	0	Dendrite;Cytoskeleton	NA	The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.	Is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).;Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity).;MAP2 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	2
+NX_P11142	Heat shock cognate 71 kDa protein	646	70898	5.37	0	Cytoplasm;Melanosome;Nucleolus;Cell membrane	NA	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24318877, PubMed:27474739, PubMed:24121476, PubMed:26865365). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). Interacts with VGF-derived peptide TLQP-21 (PubMed:28934328).	Trimethylation at Lys-561 reduces fibrillar SNCA binding.;ISGylated.;Acetylated.	Belongs to the heat shock protein 70 family.	Spliceosome;MAPK signaling pathway;Protein processing in endoplasmic reticulum;Endocytosis;Antigen processing and presentation;Legionellosis;Toxoplasmosis;Measles;Influenza A;AUF1 (hnRNP D0) binds and destabilizes mRNA;Regulation of HSF1-mediated heat shock response;mRNA Splicing - Major Pathway;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;GABA synthesis, release, reuptake and degradation;Attenuation phase;HSF1-dependent transactivation;CHL1 interactions;Clathrin-mediated endocytosis;Neutrophil degranulation;Interleukin-4 and Interleukin-13 signaling;Protein methylation;HSP90 chaperone cycle for steroid hormone receptors (SHR);Chaperone Mediated Autophagy;Lipophagy;Microautophagy	PE1	11
+NX_P11150	Hepatic triacylglycerol lipase	499	55914	9.22	0	Secreted	Hepatic lipase deficiency	Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Glycerolipid metabolism;Metabolic pathways;Assembly of active LPL and LIPC lipase complexes;Chylomicron clearance	PE1	15
+NX_P11161	E3 SUMO-protein ligase EGR2	476	50302	9.02	0	Nucleoplasm;Nucleus	Neuropathy, congenital hypomyelinating, 1, autosomal recessive;Charcot-Marie-Tooth disease 1D;Dejerine-Sottas syndrome	Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.;E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.	Ubiquitinated by WWP2 leading to proteasomal degradation.	Belongs to the EGR C2H2-type zinc-finger protein family.	Protein modification; protein sumoylation.;Transcriptional regulation of white adipocyte differentiation;Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	10
+NX_P11166	Solute carrier family 2, facilitated glucose transporter member 1	492	54084	8.93	12	Melanosome;Cell membrane	Epilepsy, idiopathic generalized 12;Dystonia 9;Stomatin-deficient cryohydrocytosis with neurologic defects;GLUT1 deficiency syndrome 1;GLUT1 deficiency syndrome 2	Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:10227690). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690).	Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization.	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Carbohydrate degradation.;Adipocytokine signaling pathway;Bile secretion;HTLV-I infection;Pathways in cancer;Renal cell carcinoma;Vitamin C (ascorbate) metabolism;Regulation of insulin secretion;Cellular hexose transport;Lactose synthesis;Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	PE1	1
+NX_P11168	Solute carrier family 2, facilitated glucose transporter member 2	524	57490	8.09	12	Cell membrane	Fanconi-Bickel syndrome	Facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969).	N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Type II diabetes mellitus;Maturity onset diabetes of the young;Carbohydrate digestion and absorption;Regulation of gene expression in beta cells;Regulation of insulin secretion;Cellular hexose transport;Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS);Intestinal hexose absorption	PE1	3
+NX_P11169	Solute carrier family 2, facilitated glucose transporter member 3	496	53924	6.84	12	Perikaryon;Cell projection;Cell membrane	NA	Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).	NA	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Vitamin C (ascorbate) metabolism;Cellular hexose transport;Neutrophil degranulation;MECP2 regulates neuronal receptors and channels	PE1	12
+NX_P11171	Protein 4.1	864	97017	5.42	0	Cell cortex;Cell membrane;Cell junction;Cytosol;Spindle;Nucleus;Cytoskeleton	Elliptocytosis 1	Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).	O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.;Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.;Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.	NA	Tight junction;Neurexins and neuroligins	PE1	1
+NX_P11172	Uridine 5'-monophosphate synthase	480	52222	6.81	0	Cytosol	Orotic aciduria 1	NA	NA	In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.;In the C-terminal section; belongs to the OMP decarboxylase family.	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.;Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.;Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine biosynthesis	PE1	3
+NX_P11177	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	359	39233	6.2	0	Mitochondrion matrix;Cytoplasm;Nucleoplasm;Mitochondrion	Pyruvate dehydrogenase E1-beta deficiency	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.	NA	NA	Glycolysis / Gluconeogenesis;Citrate cycle (TCA cycle);Valine, leucine and isoleucine biosynthesis;Pyruvate metabolism;Butanoate metabolism;Metabolic pathways;Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex;Pyruvate metabolism;Glyoxylate metabolism and glycine degradation	PE1	3
+NX_P11182	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial	482	53487	8.71	0	Mitochondrion matrix;Mitochondrion	Maple syrup urine disease 2	The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.	NA	Belongs to the 2-oxoacid dehydrogenase family.	Valine, leucine and isoleucine degradation;Metabolic pathways;Branched-chain amino acid catabolism;Glyoxylate metabolism and glycine degradation	PE1	1
+NX_P11215	Integrin alpha-M	1152	127179	6.88	1	Membrane raft;Cell membrane	Systemic lupus erythematosus 6	Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).	NA	Belongs to the integrin alpha chain family.	Phagosome;Cell adhesion molecules (CAMs);Hematopoietic cell lineage;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Pertussis;Legionellosis;Leishmaniasis;Amoebiasis;Staphylococcus aureus infection;Tuberculosis;Toll Like Receptor 4 (TLR4) Cascade;Integrin cell surface interactions;Cell surface interactions at the vascular wall;Neutrophil degranulation;Interleukin-4 and Interleukin-13 signaling	PE1	16
+NX_P11216	Glycogen phosphorylase, brain form	843	96696	6.4	0	Cytosol	NA	Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228).	Phosphorylated (PubMed:27402852). Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A (By similarity).	Belongs to the glycogen phosphorylase family.	Starch and sucrose metabolism;Insulin signaling pathway;Glycogen breakdown (glycogenolysis);Neutrophil degranulation	PE1	20
+NX_P11217	Glycogen phosphorylase, muscle form	842	97092	6.57	0	NA	Glycogen storage disease 5	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.;PYGM is phosphorylated by LMTK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PYGM is phosphorylated by PHKG2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PYGM is phosphorylated by PHKG1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the glycogen phosphorylase family.	Starch and sucrose metabolism;Insulin signaling pathway;Glycogen breakdown (glycogenolysis)	PE1	11
+NX_P11226	Mannose-binding protein C	248	26144	5.39	0	Secreted	NA	Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.	NA	NA	Phagosome;Complement and coagulation cascades;Staphylococcus aureus infection;Initial triggering of complement;Lectin pathway of complement activation	PE1	10
+NX_P11229	Muscarinic acetylcholine receptor M1	460	51421	9.45	7	Nucleoplasm;Cytosol;Cell membrane;Postsynaptic cell membrane	NA	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.	NA	Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Cholinergic synapse;Regulation of actin cytoskeleton;G alpha (q) signalling events;Muscarinic acetylcholine receptors	PE1	11
+NX_P11230	Acetylcholine receptor subunit beta	501	56698	5.5	4	Postsynaptic cell membrane;Cell membrane	Myasthenic syndrome, congenital, 2A, slow-channel;Myasthenic syndrome, congenital, 2C, associated with acetylcholine receptor deficiency	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily.	Neuroactive ligand-receptor interaction	PE1	17
+NX_P11233	Ras-related protein Ral-A	206	23567	6.66	0	Midbody ring;Focal adhesion;Cleavage furrow;Cell membrane	NA	Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269).	Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant do not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).	Belongs to the small GTPase superfamily. Ras family.	Pathways in cancer;Pancreatic cancer;Translocation of SLC2A4 (GLUT4) to the plasma membrane;p38MAPK events;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	7
+NX_P11234	Ras-related protein Ral-B	206	23409	6.24	0	Midbody;Cell membrane	NA	Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).	The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of geranylgeranyltransferase I inhibitors, including GGTI-2417.;Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).	Belongs to the small GTPase superfamily. Ras family.	Pathways in cancer;Pancreatic cancer;p38MAPK events	PE1	2
+NX_P11245	Arylamine N-acetyltransferase 2	290	33542	5.6	0	Cytoplasm	NA	Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.	NA	Belongs to the arylamine N-acetyltransferase family.	Caffeine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Acetylation	PE1	8
+NX_P11274	Breakpoint cluster region protein	1271	142819	6.62	0	Dendritic spine;Nucleoplasm;Postsynaptic density;Synapse;Cytosol;Axon	Leukemia, chronic myeloid	Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119).	Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.;BCR is phosphorylated by FES (Phosphotyrosine:PTM-0255)	NA	Pathways in cancer;Chronic myeloid leukemia;Signaling by FGFR1 in disease;Rho GTPase cycle;Signaling by cytosolic FGFR1 fusion mutants	PE1	22
+NX_P11277	Spectrin beta chain, erythrocytic	2137	246468	5.15	0	Cytosol;Cell cortex;Cytoskeleton	Spherocytosis 2;Elliptocytosis 3	Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.	The first phosphorylation event occurs on Ser-2114, followed by Ser-2125, Ser-2123, Ser-2128, Ser-2117, and Thr-2110.	Belongs to the spectrin family.	RAF/MAP kinase cascade;Interaction between L1 and Ankyrins;NCAM signaling for neurite out-growth;COPI-mediated anterograde transport	PE1	14
+NX_P11279	Lysosome-associated membrane glycoprotein 1	417	44882	9	1	Lysosome membrane;Cell membrane;Late endosome;Endosome membrane	NA	Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.;Acts as a receptor for Lassa virus protein.	O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.	Belongs to the LAMP family.	Lysosome;Phagosome;Tuberculosis;Neutrophil degranulation	PE1	13
+NX_P11308	Transcriptional regulator ERG	486	54608	7.01	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Ewing sarcoma	Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.	NA	Belongs to the ETS family.	NA	PE1	21
+NX_P11309	Serine/threonine-protein kinase pim-1	313	35686	5.72	0	Cytoplasm;Cell membrane;Nucleolus;Cytosol;Nucleus	NA	Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (PubMed:18056989).	Autophosphorylated on both serine/threonine and tyrosine residues. Phosphorylated. Interaction with PPP2CA promotes dephosphorylation.;Ubiquitinated, leading to proteasomal degradation.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.	Jak-STAT signaling pathway;Acute myeloid leukemia;Interleukin-4 and Interleukin-13 signaling	PE1	6
+NX_P11310	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	421	46588	8.61	0	Mitochondrion matrix;Mitochondrion	Acyl-CoA dehydrogenase medium-chain deficiency	Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).	Acetylation at Lys-307 and Lys-311 in proximity of the cofactor-binding sites reduces catalytic activity (By similarity). These sites are deacetylated by SIRT3.	Belongs to the acyl-CoA dehydrogenase family.	Lipid metabolism; mitochondrial fatty acid beta-oxidation.;Fatty acid metabolism;Valine, leucine and isoleucine degradation;beta-Alanine metabolism;Propanoate metabolism;Metabolic pathways;PPAR signaling pathway;PPARA activates gene expression;mitochondrial fatty acid beta-oxidation of unsaturated fatty acids;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA	PE1	1
+NX_P11362	Fibroblast growth factor receptor 1	822	91868	5.82	1	Cytoplasmic vesicle;Cytosol;Nucleus;Cell membrane	Hartsfield syndrome;Jackson-Weiss syndrome;Pfeiffer syndrome;Trigonocephaly 1;Encephalocraniocutaneous lipomatosis;Osteoglophonic dysplasia;Hypogonadotropic hypogonadism 2 with or without anosmia	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.	Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer and proceeds in a highly ordered manner. Initial autophosphorylation at Tyr-653 increases the kinase activity by a factor of 50 to 100. After this, Tyr-583 becomes phosphorylated, followed by phosphorylation of Tyr-463, Tyr-766, Tyr-583 and Tyr-585. In a third stage, Tyr-654 is autophosphorylated, resulting in a further tenfold increase of kinase activity. Phosphotyrosine residues provide docking sites for interacting proteins and so are crucial for FGFR1 function and its regulation.;N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus.;Ubiquitinated. FGFR1 is rapidly ubiquitinated by NEDD4 after autophosphorylation, leading to internalization and lysosomal degradation. CBL is recruited to activated FGFR1 via FRS2 and GRB2, and mediates ubiquitination and subsequent degradation of FGFR1.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.	MAPK signaling pathway;Adherens junction;Regulation of actin cytoskeleton;Pathways in cancer;Prostate cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR1;FGFR1c ligand binding and activation;FGFR1c and Klotho ligand binding and activation;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;Negative regulation of FGFR1 signaling;Signaling by FGFR1 in disease;Signal transduction by L1;NCAM signaling for neurite out-growth;FGFR1b ligand binding and activation;Signaling by FGFR1 amplification mutants;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;Signaling by plasma membrane FGFR1 fusions	PE1	8
+NX_P11387	DNA topoisomerase 1	765	90726	9.33	0	Nucleoplasm;Nucleolus;Nucleus	NA	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.	Phosphorylation at Ser-506 by CK2 increases binding to supercoiled DNA and sensitivity to camptothecin.;Sumoylated. Lys-117 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1 between nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT) treatment.	Belongs to the type IB topoisomerase family.	SUMOylation of DNA replication proteins	PE1	20
+NX_P11388	DNA topoisomerase 2-alpha	1531	174385	8.82	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).	Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.;TOP2A is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the type II topoisomerase family.	SUMOylation of DNA replication proteins;Transcription of E2F targets under negative control by DREAM complex	PE1	17
+NX_P11413	Glucose-6-phosphate 1-dehydrogenase	515	59257	6.39	0	Cytoplasm;Cytosol;Centriolar satellite	Anemia, non-spherocytic hemolytic, due to G6PD deficiency	Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.	Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity.	Belongs to the glucose-6-phosphate dehydrogenase family.	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.;Pentose phosphate pathway;Glutathione metabolism;Metabolic pathways;Pentose phosphate pathway;TP53 Regulates Metabolic Genes	PE1	X
+NX_P11441	Ubiquitin-like protein 4A	157	17777	8.71	0	Nucleoplasm;Cytosol;Nucleus	NA	As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).	Polyubiquitinated. Ubiquitination by AMFR and deubiquitination by USP13 may regulate the interaction between the BAG6/BAT3 complex and SGTA and therefore may regulate client proteins fate.	NA	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	X
+NX_P11464	Pregnancy-specific beta-1-glycoprotein 1	419	47223	8.32	0	Secreted	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall	PE1	19
+NX_P11465	Pregnancy-specific beta-1-glycoprotein 2	335	37216	7.66	0	Secreted	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall	PE1	19
+NX_P11473	Vitamin D3 receptor	427	48289	6.08	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Rickets vitamin D-dependent 2A	Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity).	NA	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Endocrine and other factor-regulated calcium reabsorption;Mineral absorption;Tuberculosis;Vitamin D (calciferol) metabolism;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors	PE1	12
+NX_P11474	Steroid hormone receptor ERR1	423	45510	6.01	0	Cytoplasm;Nucleolus;Nucleoplasm;Nucleus;Cytoskeleton	NA	Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.	Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.;Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding.;Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.;ESRRA is phosphorylated by CDK7	Belongs to the nuclear hormone receptor family. NR3 subfamily.	PPARA activates gene expression;Transcriptional activation of mitochondrial biogenesis;Nuclear Receptor transcription pathway;Regulation of RUNX2 expression and activity	PE1	11
+NX_P11487	Fibroblast growth factor 3	239	26887	10.88	0	Secreted	Deafness with labyrinthine aplasia, microtia and microdontia	Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;FGFR2b ligand binding and activation;PI3K Cascade;PIP3 activates AKT signaling;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Signaling by FGFR2 in disease;FGFR1b ligand binding and activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;FGFRL1 modulation of FGFR1 signaling	PE1	11
+NX_P11488	Guanine nucleotide-binding protein G(t) subunit alpha-1	350	40041	5.4	0	Membrane;Photoreceptor outer segment	Night blindness, congenital stationary, autosomal dominant 3;Night blindness, congenital stationary, 1G	Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity).	NA	Belongs to the G-alpha family. G(i/o/t/z) subfamily.	Phototransduction;G alpha (i) signalling events;Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;G-protein activation;PLC beta mediated events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	3
+NX_P11498	Pyruvate carboxylase, mitochondrial	1178	129634	6.37	0	Mitochondrion matrix;Mitochondrion	Pyruvate carboxylase deficiency	Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.	Acetylation of Lys-748 might play a role in catalytic activity regulation.	NA	Carbohydrate biosynthesis; gluconeogenesis.;Citrate cycle (TCA cycle);Pyruvate metabolism;Metabolic pathways;Gluconeogenesis;Biotin transport and metabolism;Defective HLCS causes multiple carboxylase deficiency	PE1	11
+NX_P11509	Cytochrome P450 2A6	494	56517	9.24	0	Microsome membrane;Endoplasmic reticulum membrane	NA	Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.	NA	Belongs to the cytochrome P450 family.	Caffeine metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Xenobiotics;CYP2E1 reactions	PE1	19
+NX_P11511	Aromatase	503	57883	7.2	2	Endoplasmic reticulum membrane;Endoplasmic reticulum;Microsome membrane;Mitochondrion	Aromatase deficiency;Aromatase excess syndrome	A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively (PubMed:27702664, PubMed:2848247). Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid (PubMed:20385561). Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen (PubMed:22773874). Also displays 2-hydroxylase activity toward estrone (PubMed:22773874). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:20385561, PubMed:22773874).	Phosphorylated in vitro by PKA and PKG/PRKG1. These phosphorylations inhibit the catalytic activity as measured by estrone synthesis from androstenedione (36% decrease for PKA and 30% for PKG/PRKG1).	Belongs to the cytochrome P450 family.	Steroid hormone biosynthesis.;Steroid hormone biosynthesis;Metabolic pathways;Endogenous sterols;Estrogen biosynthesis;Defective CYP19A1 causes Aromatase excess syndrome (AEXS)	PE1	15
+NX_P11532	Dystrophin	3685	426750	5.64	0	Postsynaptic cell membrane;Sarcolemma;Cytoskeleton	Duchenne muscular dystrophy;Becker muscular dystrophy;Cardiomyopathy, dilated, X-linked 3B	Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.	NA	NA	Striated Muscle Contraction;Non-integrin membrane-ECM interactions	PE1	X
+NX_P11586	C-1-tetrahydrofolate synthase, cytoplasmic	935	101559	6.89	0	Cytoplasm;Cytosol	Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia;Colorectal cancer;Neural tube defects, folate-sensitive	NA	NA	In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.;In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.	One-carbon metabolism; tetrahydrofolate interconversion.;One carbon pool by folate;Metabolic pathways;Metabolism of folate and pterines	PE1	14
+NX_P11597	Cholesteryl ester transfer protein	493	54756	5.7	0	Extracellular space	Hyperalphalipoproteinemia 1	Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).	NA	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	LDL remodeling;HDL remodeling	PE1	16
+NX_P11678	Eosinophil peroxidase	715	81040	10.31	0	Cytoplasmic granule	Eosinophil peroxidase deficiency	Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.	NA	Belongs to the peroxidase family. XPO subfamily.	Asthma;Neutrophil degranulation	PE1	17
+NX_P11684	Uteroglobin	91	9994	4.99	0	Secreted	NA	Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.	NA	Belongs to the secretoglobin family.	NA	PE1	11
+NX_P11686	Pulmonary surfactant-associated protein C	197	21053	6.19	0	Surface film	Respiratory distress syndrome in premature infants;Pulmonary surfactant metabolism dysfunction 2	Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.	NA	NA	Surfactant metabolism;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4);Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)	PE1	8
+NX_P11712	Cytochrome P450 2C9	490	55628	8.13	0	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:7574697, PubMed:15766564, PubMed:19965576, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9866708, PubMed:9435160). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; arachidonate metabolism.;Steroid metabolism; cholesterol metabolism.;Terpene metabolism; (4R)-limonene degradation.;Arachidonic acid metabolism;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Xenobiotics;Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET);CYP2E1 reactions;Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE);Biosynthesis of maresin-like SPMs	PE1	10
+NX_P11717	Cation-independent mannose-6-phosphate receptor	2491	274375	5.64	1	Golgi apparatus;Lysosome membrane;Cytoplasmic vesicle	NA	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.	NA	Belongs to the MRL1/IGF2R family.	Lysosome;Golgi Associated Vesicle Biogenesis;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Neutrophil degranulation	PE1	6
+NX_P11766	Alcohol dehydrogenase class-3	374	39724	7.45	0	Cytoplasm	NA	Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164).	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glycolysis / Gluconeogenesis;Fatty acid metabolism;Tyrosine metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Ethanol oxidation	PE1	4
+NX_P11801	Serine/threonine-protein kinase H1	424	48035	9.82	0	Golgi apparatus;Cytoplasm;Nucleus speckle;Endoplasmic reticulum membrane;Cell membrane;Nucleoplasm;Centrosome	NA	May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.	Myristoylated. Required for membrane association. Prerequisite for palmitoylation to occur.;Autophosphorylated on serine residues.;Palmitoylated.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	16
+NX_P11802	Cyclin-dependent kinase 4	303	33730	6.52	0	Cytoplasm;Nucleolus;Nucleus membrane;Nucleoplasm;Cytosol;Nucleus	Melanoma, cutaneous malignant 3	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.	Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T-loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Cell cycle;p53 signaling pathway;Tight junction;T cell receptor signaling pathway;Measles;HTLV-I infection;Pathways in cancer;Pancreatic cancer;Glioma;Melanoma;Bladder cancer;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;RMTs methylate histone arginines;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Meiotic recombination;SCF(Skp2)-mediated degradation of p27/p21;Oncogene Induced Senescence;Transcriptional regulation of white adipocyte differentiation;Cyclin D associated events in G1;PTK6 Regulates Cell Cycle;Transcriptional regulation by RUNX2;Ubiquitin-dependent degradation of Cyclin D;Transcriptional regulation of granulopoiesis;Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4;Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6;Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4;Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	PE1	12
+NX_P11831	Serum response factor	508	51593	7.83	0	Nucleoplasm;Nucleus	NA	SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation.	Phosphorylated by PRKDC.	NA	MAPK signaling pathway;HTLV-I infection;RHO GTPases Activate Formins;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	6
+NX_P11836	B-lymphocyte antigen CD20	297	33077	5.04	4	Cell membrane	Immunodeficiency, common variable, 5	B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602).	Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate.	Belongs to the MS4A family.	Hematopoietic cell lineage	PE1	11
+NX_P11844	Gamma-crystallin A	174	20877	8.05	0	NA	NA	Crystallins are the dominant structural components of the vertebrate eye lens.	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	2
+NX_P11908	Ribose-phosphate pyrophosphokinase 2	318	34769	6.15	0	NA	NA	Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.	NA	Belongs to the ribose-phosphate pyrophosphokinase family.	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.;Pentose phosphate pathway;Purine metabolism;Metabolic pathways;5-Phosphoribose 1-diphosphate biosynthesis	PE1	X
+NX_P11912	B-cell antigen receptor complex-associated protein alpha chain	226	25038	4.87	1	Cell membrane	Agammaglobulinemia 3, autosomal recessive	Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.	Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).;Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.;CD79A is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	NA	B cell receptor signaling pathway;Primary immunodeficiency;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CD22 mediated BCR regulation	PE1	19
+NX_P11926	Ornithine decarboxylase	461	51148	5.1	0	Cytosol;Cell membrane	NA	Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.	S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.	Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.;Arginine and proline metabolism;Glutathione metabolism;Metabolic pathways;Regulation of ornithine decarboxylase (ODC);Metabolism of polyamines	PE1	2
+NX_P11940	Polyadenylate-binding protein 1	636	70671	9.52	0	Cytoplasm;Nucleus	NA	(Microbial infection) Positively regulates the replication of dengue virus (DENV).;Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299).	Phosphorylated by MAPKAPK2.;Methylated by CARM1. Arg-493 is dimethylated, probably to asymmetric dimethylarginine.;PABPC1 is phosphorylated by MAPKAPK2	Belongs to the polyadenylate-binding protein type-1 family.	RNA transport;mRNA surveillance pathway;RNA degradation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Deadenylation of mRNA;Regulation of expression of SLITs and ROBOs	PE1	8
+NX_P12004	Proliferating cell nuclear antigen	261	28769	4.57	0	Nucleoplasm;Nucleus	Ataxia-telangiectasia-like disorder 2	Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737).	Phosphorylated. Phosphorylation at Tyr-211 by EGFR stabilizes chromatin-associated PCNA.;Methylated on glutamate residues by ARMT1/C6orf211.;Acetylated by CREBBP and p300/EP300; preferentially acetylated by CREBBP on Lys-80, Lys-13 and Lys-14 and on Lys-77 by p300/EP300 upon loading on chromatin in response to UV irradiation (PubMed:24939902, PubMed:19419956). Lysine acetylation disrupts association with chromatin, hence promoting PCNA ubiquitination and proteasomal degradation in response to UV damage in a CREBBP- and EP300-dependent manner (PubMed:24939902). Acetylation disrupts interaction with NUDT15 and promotes degradation (PubMed:19419956).;Ubiquitinated (PubMed:24939902, PubMed:20227374). Following DNA damage, can be either monoubiquitinated to stimulate direct bypass of DNA lesions by specialized DNA polymerases or polyubiquitinated to promote recombination-dependent DNA synthesis across DNA lesions by template switching mechanisms. Following induction of replication stress, monoubiquitinated by the UBE2B-RAD18 complex on Lys-164, leading to recruit translesion (TLS) polymerases, which are able to synthesize across DNA lesions in a potentially error-prone manner. An error-free pathway also exists and requires non-canonical polyubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases, HLTF, RNF8 and SHPRH. This error-free pathway, also known as template switching, employs recombination mechanisms to synthesize across the lesion, using as a template the undamaged, newly synthesized strand of the sister chromatid. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by the DCX(DTL) complex, leading to enhance PCNA-dependent translesion DNA synthesis. Sumoylated during S phase.	Belongs to the PCNA family.	DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Cell cycle;HTLV-I infection;Translesion Synthesis by POLH;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);G1/S-Specific Transcription;Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Polymerase switching on the C-strand of the telomere;Processive synthesis on the C-strand of the telomere;Telomere C-strand (Lagging Strand) Synthesis;Removal of the Flap Intermediate from the C-strand;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;SUMOylation of DNA replication proteins;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;E3 ubiquitin ligases ubiquitinate target proteins;Transcription of E2F targets under negative control by DREAM complex	PE1	20
+NX_P12018	Immunoglobulin iota chain	145	16605	6.3	0	NA	NA	Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.	NA	Belongs to the immunoglobulin superfamily.	Cell surface interactions at the vascular wall	PE1	22
+NX_P12034	Fibroblast growth factor 5	268	29551	10.54	0	Nucleoplasm;Cytosol;Secreted;Nucleolus	Trichomegaly	Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR1;Signaling by activated point mutants of FGFR3;FGFR3c ligand binding and activation;FGFR1c ligand binding and activation;FGFR2c ligand binding and activation;FGFR3 mutant receptor activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;FGFRL1 modulation of FGFR1 signaling;Signaling by FGFR3 point mutants in cancer	PE1	4
+NX_P12035	Keratin, type II cytoskeletal 3	628	64417	6.12	0	NA	Corneal dystrophy, Meesmann	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_P12036	Neurofilament heavy polypeptide	1026	112479	5.99	0	Cytoplasm	Amyotrophic lateral sclerosis;Charcot-Marie-Tooth disease 2CC	Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.	Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.;Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.;There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.;NEFH is phosphorylated by MAPK14 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);NEFH is phosphorylated by PKN1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the intermediate filament family.	Amyotrophic lateral sclerosis (ALS)	PE1	22
+NX_P12074	Cytochrome c oxidase subunit 6A1, mitochondrial	109	12155	9.3	0	Mitochondrion inner membrane;Mitochondrion	Charcot-Marie-Tooth disease, recessive, intermediate type, D	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase subunit 6A family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	12
+NX_P12081	Histidine--tRNA ligase, cytoplasmic	509	57411	5.72	0	Cytoplasm;Cytosol	Charcot-Marie-Tooth disease 2W;Usher syndrome 3B	Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance.	NA	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation	PE1	5
+NX_P12104	Fatty acid-binding protein, intestinal	132	15207	6.62	0	Cytoplasm;Cytosol;Cytoskeleton;Cell membrane	NA	FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	PPAR signaling pathway;Fat digestion and absorption;Triglyceride catabolism	PE1	4
+NX_P12107	Collagen alpha-1(XI) chain	1806	181065	5.06	0	Endoplasmic reticulum;Extracellular matrix	Stickler syndrome 2;Fibrochondrogenesis 1;Marshall syndrome	May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.	N-glycosylated.;Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the fibrillar collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Collagen degradation;Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;Non-integrin membrane-ECM interactions;MET activates PTK2 signaling;Collagen chain trimerization	PE1	1
+NX_P12109	Collagen alpha-1(VI) chain	1028	108529	5.26	0	Cytosol;Extracellular matrix	Bethlem myopathy 1;Ullrich congenital muscular dystrophy 1	Collagen VI acts as a cell-binding protein.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the type VI collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	21
+NX_P12110	Collagen alpha-2(VI) chain	1019	108579	5.85	0	Membrane;Cytosol;Extracellular matrix;Cell membrane	Bethlem myopathy 1;Ullrich congenital muscular dystrophy 1;Myosclerosis autosomal recessive	Collagen VI acts as a cell-binding protein.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the type VI collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	21
+NX_P12111	Collagen alpha-3(VI) chain	3177	343669	6.26	0	Extracellular matrix	Bethlem myopathy 1;Dystonia 27;Ullrich congenital muscular dystrophy 1	Collagen VI acts as a cell-binding protein.	The N-terminus is blocked.;Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the type VI collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	2
+NX_P12235	ADP/ATP translocase 1	298	33064	9.78	6	Mitochondrion inner membrane	Mitochondrial DNA depletion syndrome 12B, cardiomyopathic type;Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 2;Mitochondrial DNA depletion syndrome 12A, cardiomyopathic type	Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Calcium signaling pathway;Parkinson's disease;Huntington's disease;HTLV-I infection;Mitochondrial protein import;Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane;Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	PE1	4
+NX_P12236	ADP/ATP translocase 3	298	32866	9.76	6	Mitochondrion inner membrane	NA	Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.	Trimethylated by ANTKMT at Lys-52.	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Calcium signaling pathway;Parkinson's disease;Huntington's disease;Influenza A;HTLV-I infection;Mitochondrial protein import;Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane;Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization;Influenza Virus Induced Apoptosis	PE1	X
+NX_P12259	Coagulation factor V	2224	251703	5.68	0	Golgi apparatus;Secreted	Ischemic stroke;Budd-Chiari syndrome;Pregnancy loss, recurrent, 1;Thrombophilia due to activated protein C resistance;Factor V deficiency	Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.	Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.;Phosphorylated by FAM20C in the extracellular medium.;Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).;Activated protein C inactivates factor V and factor Va by proteolytic degradation.	Belongs to the multicopper oxidase family.	Complement and coagulation cascades;Common Pathway of Fibrin Clot Formation;Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);COPII-mediated vesicle transport;Cargo concentration in the ER;Post-translational protein phosphorylation	PE1	1
+NX_P12268	Inosine-5'-monophosphate dehydrogenase 2	514	55805	6.44	0	Cytoplasm;Cytosol;Nucleus	NA	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	The N-terminus is blocked.;Acetylated by CLOCK in a circadian manner (PubMed:28985504).	Belongs to the IMPDH/GMPR family.	Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.;Purine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Purine ribonucleoside monophosphate biosynthesis;Neutrophil degranulation	PE1	3
+NX_P12270	Nucleoprotein TPR	2363	267293	4.97	0	Cytoplasm;Nuclear pore complex;Nucleus membrane;Nucleus envelope;Nucleus;Spindle;Kinetochore	NA	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases.	Phosphorylated. Phosphorylation occurs on serine and threonine residues (comprised in the C-terminal region) by MAPK1/ERK2 and stabilizes the interaction between these two proteins.;Proteolytically degraded after poliovirus (PV) infection; degradation is restricted to its unfolded C-terminal tail domain whereas its coiled-coil domain containing NCP- and NUP153-binding domains withstand degradation.	Belongs to the TPR family.	RNA transport;Pathways in cancer;Thyroid cancer;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	1
+NX_P12271	Retinaldehyde-binding protein 1	317	36474	4.98	0	Nucleoplasm;Cytosol;Cytoplasm;Centrosome	Bothnia retinal dystrophy;Rod-cone dystrophy Newfoundland;Retinitis punctata albescens	Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.	NA	NA	The canonical retinoid cycle in rods (twilight vision);The retinoid cycle in cones (daylight vision);Retinoid cycle disease events	PE1	15
+NX_P12272	Parathyroid hormone-related protein	177	20194	10.19	0	Cytoplasm;Golgi apparatus;Secreted;Nucleoplasm;Cytosol;Nucleus	Brachydactyly E2	Osteostatin is a potent inhibitor of osteoclastic bone resorption.;Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.	There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.	Belongs to the parathyroid hormone family.	G alpha (s) signalling events;Class B/2 (Secretin family receptors)	PE1	12
+NX_P12273	Prolactin-inducible protein	146	16572	8.26	0	Secreted	NA	NA	NA	Belongs to the PIP family.	Miscellaneous transport and binding events	PE1	7
+NX_P12277	Creatine kinase B-type	381	42644	5.34	0	Cytoplasm;Cytosol	NA	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. Creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.	NA	Belongs to the ATP:guanido phosphotransferase family.	Arginine and proline metabolism;Metabolic pathways;Creatine metabolism	PE1	14
+NX_P12314	High affinity immunoglobulin gamma Fc receptor I	374	42632	8.09	1	Cell membrane	NA	High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.	Phosphorylated on serine residues.	Belongs to the immunoglobulin superfamily. FCGR1 family.	Phagosome;Osteoclast differentiation;Hematopoietic cell lineage;Fc gamma R-mediated phagocytosis;Leishmaniasis;Staphylococcus aureus infection;Tuberculosis;Systemic lupus erythematosus;Cross-presentation of soluble exogenous antigens (endosomes);Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Interferon gamma signaling;Role of phospholipids in phagocytosis;FCGR activation	PE1	1
+NX_P12318	Low affinity immunoglobulin gamma Fc region receptor II-a	317	35001	6.19	1	Cell membrane	NA	Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.	Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.	NA	Phagosome;Osteoclast differentiation;Fc gamma R-mediated phagocytosis;Leishmaniasis;Staphylococcus aureus infection;Tuberculosis;Systemic lupus erythematosus;Regulation of actin dynamics for phagocytic cup formation;Role of phospholipids in phagocytosis;FCGR activation;Neutrophil degranulation	PE1	1
+NX_P12319	High affinity immunoglobulin epsilon receptor subunit alpha	257	29596	6.23	1	Cell membrane	NA	Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.	NA	NA	Fc epsilon RI signaling pathway;Asthma;FCERI mediated NF-kB activation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Fc epsilon receptor (FCERI) signaling	PE1	1
+NX_P12429	Annexin A3	323	36375	5.63	0	Cytosol	NA	Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.	NA	Belongs to the annexin family.	NA	PE1	4
+NX_P12524	Protein L-Myc	364	40327	5.47	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	1
+NX_P12525	Putative myc-like protein MYCLP1	358	40868	5.14	0	Nucleus	NA	NA	NA	NA	NA	PE5	X
+NX_P12532	Creatine kinase U-type, mitochondrial	417	47037	8.6	0	Mitochondrion inner membrane	NA	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. Creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.	NA	Belongs to the ATP:guanido phosphotransferase family.	Arginine and proline metabolism;Metabolic pathways;Arginine and proline metabolism;Metabolic pathways;Creatine metabolism	PE1	15
+NX_P12544	Granzyme A	262	28999	9.14	0	Cytoplasmic granule;Secreted	NA	Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.	NA	Belongs to the peptidase S1 family. Granzyme subfamily.	Neuroactive ligand-receptor interaction	PE1	5
+NX_P12643	Bone morphogenetic protein 2	396	44702	9.15	0	Cytoplasmic vesicle;Secreted	Brachydactyly A2;Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies	Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).	NA	Belongs to the TGF-beta family.	Cytokine-cytokine receptor interaction;Hedgehog signaling pathway;TGF-beta signaling pathway;Pathways in cancer;Basal cell carcinoma;Signaling by BMP;Molecules associated with elastic fibres;Regulation of RUNX2 expression and activity;Transcriptional regulation by RUNX2	PE1	20
+NX_P12644	Bone morphogenetic protein 4	408	46555	8.97	0	Extracellular matrix	Microphthalmia, syndromic, 6;Non-syndromic orofacial cleft 11	Induces cartilage and bone formation. Also acts in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	NA	Belongs to the TGF-beta family.	Hedgehog signaling pathway;TGF-beta signaling pathway;Pathways in cancer;Basal cell carcinoma;Molecules associated with elastic fibres;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	14
+NX_P12645	Bone morphogenetic protein 3	472	53372	9.64	0	Secreted	NA	Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.	NA	Belongs to the TGF-beta family.	NA	PE1	4
+NX_P12694	2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial	445	50471	8.42	0	Mitochondrion matrix	Maple syrup urine disease 1A	The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	NA	Belongs to the BCKDHA family.	Valine, leucine and isoleucine degradation;Metabolic pathways;Branched-chain amino acid catabolism;Glyoxylate metabolism and glycine degradation	PE1	19
+NX_P12724	Eosinophil cationic protein	160	18385	10.12	0	Secreted	NA	Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.	NA	Belongs to the pancreatic ribonuclease family.	Asthma;Neutrophil degranulation;Antimicrobial peptides	PE1	14
+NX_P12755	Ski oncogene	728	80005	7.73	0	Nucleoplasm;Nucleus	Shprintzen-Goldberg craniosynostosis syndrome	May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.	Ubiquitinated by RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.;SKI is phosphorylated by AURKA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the SKI family.	Downregulation of SMAD2/3:SMAD4 transcriptional activity;Signaling by BMP	PE1	1
+NX_P12757	Ski-like protein	684	76976	6.72	0	Nucleoplasm;Cytosol	NA	May have regulatory role in cell division or differentiation in response to extracellular signals.	Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.	Belongs to the SKI family.	Downregulation of SMAD2/3:SMAD4 transcriptional activity	PE1	3
+NX_P12814	Alpha-actinin-1	892	103058	5.25	0	Cytoplasm;Cell membrane;Cell junction;Ruffle;Z line;Cytoskeleton	Bleeding disorder, platelet-type 15	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.	NA	Belongs to the alpha-actinin family.	Focal adhesion;Adherens junction;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Amoebiasis;Systemic lupus erythematosus;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Syndecan interactions;Platelet degranulation;Nephrin family interactions;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	PE1	14
+NX_P12821	Angiotensin-converting enzyme	1306	149715	5.95	1	Cell membrane;Cytoplasm;Secreted;Cytoplasmic vesicle	Intracerebral hemorrhage;Microvascular complications of diabetes 3;Renal tubular dysgenesis;Ischemic stroke	Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.	Phosphorylated by CK2 on Ser-1299; which allows membrane retention.	Belongs to the peptidase M2 family.	Renin-angiotensin system;Chagas disease (American trypanosomiasis);Hypertrophic cardiomyopathy (HCM);Metabolism of Angiotensinogen to Angiotensins	PE1	17
+NX_P12829	Myosin light chain 4	197	21565	4.98	0	Cell membrane	Atrial fibrillation, familial, 18	Regulatory light chain of myosin. Does not bind calcium.	NA	NA	Striated Muscle Contraction	PE1	17
+NX_P12830	Cadherin-1	882	97456	4.58	1	trans-Golgi network;Golgi apparatus;Cell membrane;Adherens junction;Cell junction;Endosome	Blepharocheilodontic syndrome 1;Endometrial cancer;Ovarian cancer;Hereditary diffuse gastric cancer;Breast cancer, lobular	E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.;Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.;(Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.	Ubiquitinated by a SCF complex containing SKP2, which requires prior phosphorylation by CK1/CSNK1A1. Ubiquitinated by CBLL1/HAKAI, requires prior phosphorylation at Tyr-754.;O-glycosylated. O-manosylated by TMTC1, TMTC2, TMTC3 or TMTC4. Thr-285 and Thr-509 are O-mannosylated by TMTC2 or TMTC4 but not TMTC1 or TMTC3.;N-glycosylation at Asn-637 is essential for expression, folding and trafficking. Addition of bisecting N-acetylglucosamine by MGAT3 modulates its cell membrane location (PubMed:19403558).;During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 (PubMed:11076937, PubMed:11953314, PubMed:10597309). Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm (PubMed:10597309). The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway (PubMed:10597309). Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system (PubMed:11076937). The gamma-secretase-mediated cleavage promotes disassembly of adherens junctions (PubMed:11953314). During development of the cochlear organ of Corti, cleavage by ADAM10 at adherens junctions promotes pillar cell separation (By similarity).;CDH1 is phosphorylated by PRKD1	NA	Cell adhesion molecules (CAMs);Adherens junction;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Pathways in cancer;Endometrial cancer;Thyroid cancer;Melanoma;Bladder cancer;Degradation of the extracellular matrix;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions;Apoptotic cleavage of cell adhesion proteins;Adherens junctions interactions;RHO GTPases activate IQGAPs;InlA-mediated entry of Listeria monocytogenes into host cells	PE1	16
+NX_P12838	Neutrophil defensin 4	97	10504	8.3	0	Secreted	NA	Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.	NA	Belongs to the alpha-defensin family.	Alpha-defensins;Defensins;Neutrophil degranulation	PE1	8
+NX_P12872	Promotilin	115	12920	6.14	0	Secreted	NA	Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.	NA	Belongs to the motilin family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	6
+NX_P12882	Myosin-1	1939	223145	5.59	0	Myofibril	NA	Muscle contraction.	MYH1 is phosphorylated by ALPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tight junction;Viral myocarditis	PE1	17
+NX_P12883	Myosin-7	1935	223097	5.63	0	Myofibril;Sarcomere	Myopathy, distal, 1;Cardiomyopathy, familial hypertrophic 1;Scapuloperoneal myopathy MYH7-related;Left ventricular non-compaction 5;Myopathy, myosin storage, autosomal dominant;Myopathy, myosin storage, autosomal recessive;Cardiomyopathy, dilated 1S	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Cardiac muscle contraction;Tight junction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Viral myocarditis	PE1	14
+NX_P12931	Proto-oncogene tyrosine-protein kinase Src	536	59835	7.1	0	Cell membrane;Cell junction;Cytosol;Mitochondrion inner membrane;Perinuclear region;Nucleus;Cytoskeleton	Thrombocytopenia 6	Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity).	Myristoylated at Gly-2, and this is essential for targeting to membranes.;Ubiquitinated in response to CDK5-mediated phosphorylation. Ubiquitination mediated by CBLC requires SRC autophosphorylation at Tyr-419 and may lead to lysosomal degradation.;S-nitrosylation is important for activation of its kinase activity.;Dephosphorylated at Tyr-530 by PTPRJ (By similarity). Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-419. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-530, the SH3 domain engaged with the SH2-kinase linker, and Tyr-419 dephosphorylated. Dephosphorylation of Tyr-530 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-530, Tyr-419 can then become autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-530 by CSK allows this interaction to reform, resulting in SRC inactivation. CDK5-mediated phosphorylation at Ser-75 targets SRC to ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. Phosphorylated by PTK2/FAK1; this enhances kinase activity. Phosphorylated by PTK2B/PYK2; this enhances kinase activity.;SRC is phosphorylated by AURKA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRC is phosphorylated by FLT1 (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.	ErbB signaling pathway;Chemokine signaling pathway;Endocytosis;VEGF signaling pathway;Focal adhesion;Adherens junction;Tight junction;Gap junction;GABAergic synapse;Regulation of actin cytoskeleton;GnRH signaling pathway;Bacterial invasion of epithelial cells;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Tuberculosis;CLEC7A (Dectin-1) signaling;G alpha (i) signalling events;G alpha (s) signalling events;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;RHO GTPases Activate Formins;EPH-Ephrin signaling;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;VEGFA-VEGFR2 Pathway;EPHA-mediated growth cone collapse;Recycling pathway of L1;Signaling by ERBB2;Nuclear signaling by ERBB4;RAF activation;MAP2K and MAPK activation;Signaling by SCF-KIT;Regulation of KIT signaling;CD28 co-stimulation;ADP signalling through P2Y purinoceptor 1;Thrombin signalling through proteinase activated receptors (PARs);Signal regulatory protein family interactions;Netrin mediated repulsion signals;Cyclin D associated events in G1;FCGR activation;PECAM1 interactions;NCAM signaling for neurite out-growth;CTLA4 inhibitory signaling;DCC mediated attractive signaling;Integrin alphaIIb beta3 signaling;VEGFR2 mediated cell proliferation;p38MAPK events;Signaling by EGFR;Spry regulation of FGF signaling;Downregulation of ERBB4 signaling;GP1b-IX-V activation signalling;Downstream signal transduction;GAB1 signalosome;GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;Regulation of commissural axon pathfinding by SLIT and ROBO;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates PTK2 signaling;InlA-mediated entry of Listeria monocytogenes into host cells;Regulation of RUNX3 expression and activity;Receptor Mediated Mitophagy;Regulation of RUNX1 Expression and Activity;RUNX2 regulates osteoblast differentiation;Activated NTRK3 signals through PI3K;Activated NTRK2 signals through FYN;Long-term potentiation;Extra-nuclear estrogen signaling;Regulation of gap junction activity	PE1	20
+NX_P12955	Xaa-Pro dipeptidase	493	54548	5.64	0	Nucleoplasm	Prolidase deficiency	Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.	NA	Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.	NA	PE1	19
+NX_P12956	X-ray repair cross-complementing protein 6	609	69843	6.23	0	Nucleoplasm;Nucleus;Chromosome	NA	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.	ADP-ribosylated by PARP3.;Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.	Belongs to the ku70 family.	Non-homologous end-joining;Cytosolic sensors of pathogen-associated DNA;IRF3-mediated induction of type I IFN;2-LTR circle formation;Nonhomologous End-Joining (NHEJ);Neutrophil degranulation	PE1	22
+NX_P12980	Protein lyl-1	280	29938	10.69	0	Golgi apparatus;Nucleus	NA	NA	NA	NA	NA	PE1	19
+NX_P13010	X-ray repair cross-complementing protein 5	732	82705	5.55	0	Nucleoplasm;Nucleolus;Nucleus;Chromosome	NA	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:20383123). The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.	ADP-ribosylated by PARP3.;Phosphorylated on serine residues. Phosphorylation by PRKDC may enhance helicase activity.;Sumoylated.;Ubiquitinated by RNF8 via 'Lys-48'-linked ubiquitination following DNA damage, leading to its degradation and removal from DNA damage sites (PubMed:22266820). Ubiquitinated by RNF138, leading to remove the Ku complex from DNA breaks (PubMed:26502055).	Belongs to the ku80 family.	Non-homologous end-joining;Cytosolic sensors of pathogen-associated DNA;IRF3-mediated induction of type I IFN;2-LTR circle formation;Nonhomologous End-Joining (NHEJ);Neutrophil degranulation	PE1	2
+NX_P13051	Uracil-DNA glycosylase	313	34645	9.37	0	Cytosol;Mitochondrion;Nucleus	Immunodeficiency with hyper-IgM 5	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	Is processed by cleavage of a transit peptide.	Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.	Base excision repair;Primary immunodeficiency;Displacement of DNA glycosylase by APEX1;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine	PE1	12
+NX_P13056	Nuclear receptor subfamily 2 group C member 1	603	67315	5.89	0	Cell junction;Nucleoplasm;PML body;Cytosol;Nucleus	NA	Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.	Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity).;Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-222, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity).	Belongs to the nuclear hormone receptor family. NR2 subfamily.	Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors	PE1	12
+NX_P13073	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	169	19577	9.52	0	Mitochondrion inner membrane;Mitochondrion	NA	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase IV family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	16
+NX_P13164	Interferon-induced transmembrane protein 1	125	13964	7.78	1	Cytosol;Cell membrane	NA	IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.	Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.	Belongs to the CD225/Dispanin family.	B cell receptor signaling pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Interferon alpha/beta signaling	PE1	11
+NX_P13196	5-aminolevulinate synthase, nonspecific, mitochondrial	640	70581	8.74	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	NA	NA	NA	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.;Glycine, serine and threonine metabolism;Porphyrin and chlorophyll metabolism;Metabolic pathways;PPARA activates gene expression;Transcriptional activation of mitochondrial biogenesis;Heme biosynthesis	PE1	3
+NX_P13224	Platelet glycoprotein Ib beta chain	206	21718	9.67	1	Membrane	Bernard-Soulier syndrome	Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.	NA	NA	ECM-receptor interaction;Hematopoietic cell lineage;Platelet Adhesion to exposed collagen;Intrinsic Pathway of Fibrin Clot Formation;GP1b-IX-V activation signalling;Platelet Aggregation (Plug Formation)	PE1	22
+NX_P13232	Interleukin-7	177	20187	8.87	0	Secreted	Epidermodysplasia verruciformis 5	Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.	NA	Belongs to the IL-7/IL-9 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Interleukin-7 signaling	PE1	8
+NX_P13236	C-C motif chemokine 4	92	10212	5.13	0	Secreted	NA	Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.	N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Cytosolic DNA-sensing pathway;Salmonella infection;Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Toll-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Salmonella infection;Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Cytosolic DNA-sensing pathway;Salmonella infection;G alpha (i) signalling events;Interleukin-10 signaling	PE1	17
+NX_P13284	Gamma-interferon-inducible lysosomal thiol reductase	250	27964	4.79	0	Cytoplasmic vesicle;Cytosol;Secreted;Lysosome	NA	Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).	N-glycosylated. Sugar chains contain mannose-6-phosphate.;Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases.	Belongs to the GILT family.	Antigen processing and presentation;MHC class II antigen presentation;Interferon gamma signaling	PE1	19
+NX_P13349	Myogenic factor 5	255	28296	5.9	0	Nucleoplasm;Nucleus	Ophthalmoplegia, external, with rib and vertebral anomalies	Transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation (PubMed:29887215). Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.	NA	NA	Myogenesis	PE1	12
+NX_P13378	Homeobox protein Hox-D8	290	31911	8.7	0	Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	NA	PE1	2
+NX_P13385	Teratocarcinoma-derived growth factor 1	188	21169	8.54	0	Secreted;Cell membrane	NA	GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953).	The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (TMEM8A), removing an acyl-chain at the sn-2 position of GPI and releasing TDGF1 as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (GPLD1) into a soluble form.	Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;Signaling by NODAL;Regulation of signaling by NODAL	PE1	3
+NX_P13473	Lysosome-associated membrane glycoprotein 2	410	44961	5.35	1	Autophagosome membrane;Endosome membrane;Cell membrane;Lysosome membrane;Cytoplasmic vesicle	Danon disease	Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.;Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).	O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.	Belongs to the LAMP family.	Lysosome;Phagosome;Tuberculosis;Platelet degranulation;Neutrophil degranulation;Chaperone Mediated Autophagy	PE1	X
+NX_P13489	Ribonuclease inhibitor	461	49973	4.71	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.	The N-terminus is blocked.;At least 30 of the 32 cysteine residues are in the reduced form.	NA	NA	PE1	11
+NX_P13497	Bone morphogenetic protein 1	986	111249	6.48	0	trans-Golgi network;Extracellular matrix	Osteogenesis imperfecta 13	Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.	Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion.	NA	Degradation of the extracellular matrix;Collagen biosynthesis and modifying enzymes;Crosslinking of collagen fibrils;Anchoring fibril formation;HDL assembly	PE1	8
+NX_P13498	Cytochrome b-245 light chain	195	21013	9.58	0	Cell membrane	Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.	The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it is possible that more than one heme is present per cytochrome b-245.;Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting p47phox binding.;Ubiquitinated at Lys-149 likely by RNF145.	Belongs to the p22phox family.	Phagosome;Osteoclast differentiation;Leukocyte transendothelial migration;Leishmaniasis;Detoxification of Reactive Oxygen Species;VEGFA-VEGFR2 Pathway;ROS and RNS production in phagocytes;Cross-presentation of particulate exogenous antigens (phagosomes);RHO GTPases Activate NADPH Oxidases;Neutrophil degranulation	PE1	16
+NX_P13500	C-C motif chemokine 2	99	11025	9.4	0	Golgi apparatus;Secreted;Cytoplasmic vesicle	NA	Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690).	N-Glycosylated.;Processing at the N-terminus can regulate receptor and target cell selectivity (PubMed:8627182). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (PubMed:8627182).	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;NOD-like receptor signaling pathway;Chagas disease (American trypanosomiasis);Malaria;Influenza A;Herpes simplex infection;Rheumatoid arthritis;ATF4 activates genes in response to endoplasmic reticulum stress;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling	PE1	17
+NX_P13501	C-C motif chemokine 5	91	9990	9.27	0	Secreted	NA	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).	N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.;The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Prion diseases;Epithelial cell signaling in Helicobacter pylori infection;Chagas disease (American trypanosomiasis);Influenza A;Herpes simplex infection;Rheumatoid arthritis;G alpha (i) signalling events;Chemokine receptors bind chemokines;Interleukin-10 signaling	PE1	17
+NX_P13521	Secretogranin-2	617	70941	4.67	0	Golgi apparatus;Secreted;Cytoplasmic vesicle	NA	Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.	O-glycosylated.	Belongs to the chromogranin/secretogranin protein family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	2
+NX_P13533	Myosin-6	1939	223735	5.58	0	Myofibril	Sick sinus syndrome 3;Cardiomyopathy, dilated 1EE;Cardiomyopathy, familial hypertrophic 14;Atrial septal defect 3	Muscle contraction.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Cardiac muscle contraction;Tight junction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Viral myocarditis;Striated Muscle Contraction	PE1	14
+NX_P13535	Myosin-8	1937	222763	5.59	0	Myofibril	Arthrogryposis, distal, 7;Carney complex variant	Muscle contraction.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tight junction;Viral myocarditis;Striated Muscle Contraction	PE1	17
+NX_P13569	Cystic fibrosis transmembrane conductance regulator	1480	168142	8.91	12	Endoplasmic reticulum membrane;Cell membrane;Recycling endosome membrane;Early endosome membrane;Apical cell membrane;Nucleus	Congenital bilateral absence of the vas deferens;Cystic fibrosis	Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17434346, PubMed:27941075, PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810).	Ubiquitinated, leading to its degradation in the lysosome (PubMed:19398555). Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane (PubMed:19398555). Ubiquitinated by RNF185 during ER stress (PubMed:24019521).;Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel (PubMed:12588899, PubMed:17036051, PubMed:8910473). Dephosphorylation decreases the ATPase activity (in vitro) (PubMed:8910473). Phosphorylation at PKA sites activates the channel (PubMed:10792060, PubMed:12519745, PubMed:12588899, PubMed:25330774). Phosphorylation at PKC sites enhances the response to phosphorylation by PKA (PubMed:12588899). Phosphorylated by AMPK; this inhibits channel activity (PubMed:12519745).;N-glycosylated.;CFTR is phosphorylated by PRKG2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);CFTR is phosphorylated by CAMK1	Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.	ABC transporters;Gastric acid secretion;Pancreatic secretion;Bile secretion;Vibrio cholerae infection;ABC-family proteins mediated transport;RHO GTPases regulate CFTR trafficking;Defective CFTR causes cystic fibrosis;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	7
+NX_P13584	Cytochrome P450 4B1	511	58991	8.47	0	Microsome membrane;Cytoplasmic vesicle;Endoplasmic reticulum membrane	NA	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	NA	Belongs to the cytochrome P450 family.	Miscellaneous substrates;Fatty acids;Eicosanoids;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	1
+NX_P13591	Neural cell adhesion molecule 1	858	94574	4.79	1	Cytosol;Secreted;Cell membrane	NA	This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.;(Microbial infection) Acts as a receptor for rabies virus.	NA	NA	Cell adhesion molecules (CAMs);Prion diseases;RAF/MAP kinase cascade;Interferon gamma signaling;NCAM1 interactions;Signal transduction by L1;ECM proteoglycans;NCAM signaling for neurite out-growth	PE1	11
+NX_P13598	Intercellular adhesion molecule 2	275	30654	7.09	1	Membrane;Cytosol;Microvillus;Cell membrane	NA	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.	NA	Belongs to the immunoglobulin superfamily. ICAM family.	Cell adhesion molecules (CAMs);Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions;CD209 (DC-SIGN) signaling	PE1	17
+NX_P13611	Versican core protein	3396	372820	4.43	0	Photoreceptor outer segment;Interphotoreceptor matrix;Extracellular matrix;Cytoplasmic vesicle	Wagner vitreoretinopathy	May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	Phosphorylated by FAM20C in the extracellular medium.	Belongs to the aggrecan/versican proteoglycan family.	Cell adhesion molecules (CAMs);Chondroitin sulfate biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Dermatan sulfate biosynthesis;CS/DS degradation;Defective CHST3 causes SEDCJD;Defective CHST14 causes EDS, musculocontractural type;Defective CHSY1 causes TPBS;Defective B3GALT6 causes EDSP2 and SEMDJL1;Post-translational protein phosphorylation	PE1	5
+NX_P13612	Integrin alpha-4	1032	114900	6.05	1	Membrane;Cell membrane	NA	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).	Phosphorylation on Ser-1027 inhibits PXN binding.	Belongs to the integrin alpha chain family.	Focal adhesion;ECM-receptor interaction;Cell adhesion molecules (CAMs);Hematopoietic cell lineage;Leukocyte transendothelial migration;Intestinal immune network for IgA production;Regulation of actin cytoskeleton;Leishmaniasis;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions;Cell surface interactions at the vascular wall;RUNX3 Regulates Immune Response and Cell Migration	PE1	2
+NX_P13631	Retinoic acid receptor gamma	454	50342	7.44	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).	NA	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Nuclear Receptor transcription pathway;Signaling by Retinoic Acid;Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	12
+NX_P13637	Sodium/potassium-transporting ATPase subunit alpha-3	1013	111749	5.22	10	Cell membrane	Cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss;Alternating hemiplegia of childhood 2;Dystonia 12	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.	Cardiac muscle contraction;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Protein digestion and absorption;Bile secretion;Mineral absorption;Ion transport by P-type ATPases;Ion homeostasis	PE1	19
+NX_P13639	Elongation factor 2	858	95338	6.41	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	Spinocerebellar ataxia 26	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.	SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage.;Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine (By similarity).;(Microbial infection) Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis.;Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.;ISGylated.;Proteolytically processed at two sites following phosphorylation by CSK.	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.	Uptake and function of diphtheria toxin;Peptide chain elongation;Synthesis of diphthamide-EEF2;Neutrophil degranulation;Protein methylation	PE1	19
+NX_P13640	Metallothionein-1G	62	6141	8.38	0	NA	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	NA	Belongs to the metallothionein superfamily. Type 1 family.	Mineral absorption;Metallothioneins bind metals	PE1	16
+NX_P13645	Keratin, type I cytoskeletal 10	584	58827	5.13	0	Cell surface;Extracellular space	Ichthyosis annular epidermolytic;Erythroderma, ichthyosiform, congenital reticular;Epidermolytic hyperkeratosis	(Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.;(Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.;Plays a role in the establishment of the epidermal barrier on plantar skin.	NA	Belongs to the intermediate filament family.	Staphylococcus aureus infection;Formation of the cornified envelope;Keratinization	PE1	17
+NX_P13646	Keratin, type I cytoskeletal 13	458	49588	4.91	0	Cytoskeleton	White sponge nevus 2	NA	O-glycosylated; glycans consist of single N-acetylglucosamine residues.	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_P13647	Keratin, type II cytoskeletal 5	590	62378	7.58	0	Cytoskeleton	Epidermolysis bullosa simplex, with mottled pigmentation;Epidermolysis bullosa simplex, Weber-Cockayne type;Epidermolysis bullosa simplex, autosomal recessive 1;Epidermolysis bullosa simplex, with migratory circinate erythema;Epidermolysis bullosa simplex, Koebner type;Epidermolysis bullosa simplex, Dowling-Meara type;Dowling-Degos disease 1	NA	NA	Belongs to the intermediate filament family.	Type I hemidesmosome assembly;Formation of the cornified envelope;Keratinization	PE1	12
+NX_P13667	Protein disulfide-isomerase A4	645	72932	4.96	0	Endoplasmic reticulum;Endoplasmic reticulum lumen;Melanosome	NA	NA	NA	Belongs to the protein disulfide isomerase family.	Protein processing in endoplasmic reticulum;Vibrio cholerae infection	PE1	7
+NX_P13671	Complement component C6	934	104786	6.39	0	Secreted	Complement component 6 deficiency	Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.	All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.	Belongs to the complement C6/C7/C8/C9 family.	Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus;Terminal pathway of complement;Regulation of Complement cascade	PE1	5
+NX_P13674	Prolyl 4-hydroxylase subunit alpha-1	534	61049	5.7	0	Endoplasmic reticulum;Cytoplasmic vesicle;Endoplasmic reticulum lumen;Mitochondrion	NA	Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.	NA	Belongs to the P4HA family.	Arginine and proline metabolism;Metabolic pathways;Collagen biosynthesis and modifying enzymes	PE1	10
+NX_P13682	Zinc finger protein 35	527	59089	8.44	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_P13686	Tartrate-resistant acid phosphatase type 5	325	36599	8.82	0	Cytosol;Lysosome	Spondyloenchondrodysplasia with immune dysregulation	Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.	NA	Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.	Riboflavin metabolism;Lysosome;Osteoclast differentiation;Rheumatoid arthritis;Vitamin B2 (riboflavin) metabolism	PE1	19
+NX_P13688	Carcinoembryonic antigen-related cell adhesion molecule 1	526	57560	5.65	1	Basal cell membrane;Lateral cell membrane;Cell membrane;Cell junction;Adherens junction;Secreted;Microvillus membrane;Secretory vesicle membrane;Apical cell membrane	NA	Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity).;Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity).	Phosphorylated on serine and threonine.;Is phosphorylated on tyrosine by Src family kinases like SRC and LCK and by receptor like CSF3R, EGFR and INSR upon stimulation (PubMed:15467833, PubMed:18424730, PubMed:7478590). Phosphorylated at Ser-508; mediates activity. Phosphorylated at Tyr-493; regulates activity (By similarity). Phosphorylated at Tyr-493 by EGFR and INSR upon stimulation; this phosphorylation is Ser-508-phosphorylation-dependent; mediates cellular internalization; increases interaction with downstream proteins like SHC1 and FASN (By similarity). Phosphorylated at Tyr-493 and Tyr-520 by LCK; mediates PTPN6 association and is regulated by homophilic ligation of CEACAM1 in the absence of T cell activation (PubMed:18424730). Phosphorylated at Tyr-520; mediates interaction with PTPN11 (By similarity).;Phosphorylated on serine and tyrosine (By similarity).;CEACAM1 is phosphorylated by EGFR (Phosphotyrosine:PTM-0255)	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall;Fibronectin matrix formation;Neutrophil degranulation	PE1	19
+NX_P13693	Translationally-controlled tumor protein	172	19595	4.84	0	Cytoplasm	NA	Involved in calcium binding and microtubule stabilization.	NA	Belongs to the TCTP family.	NA	PE1	13
+NX_P13716	Delta-aminolevulinic acid dehydratase	330	36295	6.32	0	NA	Acute hepatic porphyria	Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.	NA	Belongs to the ALAD family.	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.;Porphyrin and chlorophyll metabolism;Metabolic pathways;Heme biosynthesis;Neutrophil degranulation	PE1	9
+NX_P13725	Oncostatin-M	252	28484	10.71	0	Secreted	NA	Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).	Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.	Belongs to the LIF/OSM family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;IL-6-type cytokine receptor ligand interactions;Interleukin-4 and Interleukin-13 signaling	PE1	22
+NX_P13726	Tissue factor	295	33068	6.64	1	Membrane;Cytoplasmic vesicle;Secreted	NA	Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.	NA	Belongs to the tissue factor family.	Complement and coagulation cascades;Extrinsic Pathway of Fibrin Clot Formation	PE1	1
+NX_P13727	Bone marrow proteoglycan	222	25206	6.32	0	Secreted;Secretory vesicle	NA	Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.	Nitrated.	NA	Asthma;Neutrophil degranulation	PE1	11
+NX_P13747	HLA class I histocompatibility antigen, alpha chain E	358	40058	5.52	1	Cell membrane;Cytoplasmic vesicle;Secreted;Golgi apparatus membrane	NA	(Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells.;Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8+ cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:30087334).	The soluble form (sHLA-E) can be partly produced by proteolytic cleavage at the cell surface (shedding) by a matrix metalloproteinase. Alternative splicing is also suggested as a mechanism for generation of sHLA-E, although it remains to be proved.;N-glycosylated.	Belongs to the MHC class I family.	Endocytosis;Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Type I diabetes mellitus;HTLV-I infection;Herpes simplex infection;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;Viral myocarditis;ER-Phagosome pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Endosomal/Vacuolar pathway;Interferon gamma signaling;Interferon alpha/beta signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;DAP12 signaling;DAP12 interactions	PE1	6
+NX_P13760	HLA class II histocompatibility antigen, DRB1-4 beta chain	266	30112	6.71	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;trans-Golgi network membrane;Lysosome membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P13761	HLA class II histocompatibility antigen, DRB1-7 beta chain	266	29822	7.04	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;Lysosome membrane;trans-Golgi network membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P13762	HLA class II histocompatibility antigen, DR beta 4 chain	266	29941	6.95	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;Lysosome membrane;trans-Golgi network membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II. When associated with ubiquitination of the alpha subunit of HLA-DR: HLA-DRA 'Lys-244', the down-regulation of MHC class II may be highly effective.	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Hematopoietic cell lineage;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P13765	HLA class II histocompatibility antigen, DO beta chain	273	30822	6.31	1	Lysosome membrane;Endosome membrane	NA	Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.	NA	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation	PE1	6
+NX_P13796	Plastin-2	627	70288	5.29	0	Cell membrane;Cell junction;Cell projection;Ruffle membrane;Cytosol;Cytoskeleton	NA	Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403).	Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections.	NA	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	13
+NX_P13797	Plastin-3	630	70811	5.41	0	Cytoplasm;Cytosol;Cell membrane	Osteoporosis	Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.	NA	NA	NA	PE1	X
+NX_P13798	Acylamino-acid-releasing enzyme	732	81225	5.29	0	Cytoplasm;Cytosol	NA	This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.	NA	Belongs to the peptidase S9C family.	Eukaryotic Translation Termination;Neutrophil degranulation	PE1	3
+NX_P13804	Electron transfer flavoprotein subunit alpha, mitochondrial	333	35080	8.62	0	Mitochondrion matrix;Mitochondrion	Glutaric aciduria 2A	Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199).	The N-terminus is blocked.	Belongs to the ETF alpha-subunit/FixB family.	Respiratory electron transport	PE1	15
+NX_P13805	Troponin T, slow skeletal muscle	278	32948	5.86	0	Golgi apparatus;Nucleoplasm;Cytosol	Nemaline myopathy 5	Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	NA	Belongs to the troponin T family.	Striated Muscle Contraction	PE1	19
+NX_P13807	Glycogen [starch] synthase, muscle	737	83786	5.8	0	Cytosol;Cytoskeleton	Muscle glycogen storage disease 0	Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.	Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.;GYS1 is phosphorylated by PRKAA2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the glycosyltransferase 3 family.	Glycan biosynthesis; glycogen biosynthesis.;Starch and sucrose metabolism;Insulin signaling pathway;Glycogen synthesis;Myoclonic epilepsy of Lafora;Glycogen storage disease type XV (GYG1);Glycogen storage disease type 0 (muscle GYS1)	PE1	19
+NX_P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	404	45518	4.96	0	Cytoplasm;Cell membrane	NA	Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.	Phosphorylated by the activated catalytic chain.;PRKAR2A is phosphorylated by PRKACA	Belongs to the cAMP-dependent kinase regulatory chain family.	Apoptosis;Insulin signaling pathway;Factors involved in megakaryocyte development and platelet production;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase;ROBO receptors bind AKAP5	PE1	3
+NX_P13866	Sodium/glucose cotransporter 1	664	73498	7.82	13	Membrane;Cytoplasmic vesicle;Nucleoplasm	Congenital glucose/galactose malabsorption	Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.	N-glycosylation is not necessary for the cotransporter function.	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Carbohydrate digestion and absorption;Bile secretion;Mineral absorption;Cellular hexose transport;Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM);Intestinal hexose absorption	PE1	22
+NX_P13928	Annexin A8	327	36881	5.56	0	NA	NA	This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.	NA	Belongs to the annexin family.	NA	PE1	10
+NX_P13929	Beta-enolase	434	46987	7.58	0	Cytoplasm	Glycogen storage disease 13	Appears to have a function in striated muscle development and regeneration.	NA	Belongs to the enolase family.	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.;Glycolysis / Gluconeogenesis;Metabolic pathways;RNA degradation;Glycolysis;Gluconeogenesis	PE1	17
+NX_P13942	Collagen alpha-2(XI) chain	1736	171791	5.89	0	Extracellular matrix	Otospondylomegaepiphyseal dysplasia, autosomal recessive;Fibrochondrogenesis 2;Deafness, autosomal dominant, 13;Deafness, autosomal recessive, 53;Otospondylomegaepiphyseal dysplasia, autosomal dominant	May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.	A disulfide-bonded peptide called proline/arginine-rich protein or PARP is released from the N-terminus during extracellular processing and is subsequently retained in the cartilage matrix from which it can be isolated in significant amounts.;Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the fibrillar collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Collagen degradation;Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;Non-integrin membrane-ECM interactions;MET activates PTK2 signaling;Collagen chain trimerization	PE1	6
+NX_P13945	Beta-3 adrenergic receptor	408	43519	9.39	7	Cell membrane	NA	Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.	NA	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Endocytosis;Salivary secretion;G alpha (s) signalling events;Adrenoceptors	PE1	8
+NX_P13984	General transcription factor IIF subunit 2	249	28380	9.24	0	Nucleoplasm;Nucleus;Nucleolus;Cytoskeleton	NA	TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	NA	Belongs to the TFIIF beta subunit family.	Basal transcription factors;Viral Messenger RNA Synthesis;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	13
+NX_P13985	Putative HTLV-1-related endogenous sequence	223	24343	12.23	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_P13987	CD59 glycoprotein	128	14177	6.02	0	Golgi apparatus;Cytoplasmic vesicle;Secreted;Cell membrane	Hemolytic anemia, CD59-mediated, with or without polyneuropathy	The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.;Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.	Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes.;N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine. Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants.	NA	Complement and coagulation cascades;Hematopoietic cell lineage;Regulation of Complement cascade;COPII-mediated vesicle transport;Cargo concentration in the ER;COPI-mediated anterograde transport;Neutrophil degranulation	PE1	11
+NX_P13994	Coiled-coil domain-containing protein 130	396	44802	8.47	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the CWC16 family.	NA	PE1	19
+NX_P13995	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	350	37895	8.86	0	Mitochondrion	NA	Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.	NA	Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.	One carbon pool by folate;Metabolic pathways;Metabolism of folate and pterines	PE1	2
+NX_P14060	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	373	42252	8.86	1	Mitochondrion membrane;Endoplasmic reticulum membrane	NA	A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1401999, PubMed:2139411). Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable).	NA	Belongs to the 3-beta-HSD family.	Steroid metabolism.;Steroid hormone biosynthesis.;Steroid hormone biosynthesis;Metabolic pathways;Glucocorticoid biosynthesis;Androgen biosynthesis;Mineralocorticoid biosynthesis	PE1	1
+NX_P14061	Estradiol 17-beta-dehydrogenase 1	328	34950	5.46	0	Cytoplasm;Cytosol	NA	Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Steroid biosynthesis; estrogen biosynthesis.;Steroid hormone biosynthesis;Metabolic pathways;The canonical retinoid cycle in rods (twilight vision);Estrogen biosynthesis	PE1	17
+NX_P14091	Cathepsin E	396	42794	4.69	0	Endosome	NA	May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.	Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.;Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.	Belongs to the peptidase A1 family.	Lysosome;MHC class II antigen presentation	PE1	1
+NX_P14136	Glial fibrillary acidic protein	432	49880	5.42	0	Cytoplasm;Cytoskeleton	Alexander disease	GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.	Phosphorylated by PKN1.;GFAP is phosphorylated by PKN1	Belongs to the intermediate filament family.	Nuclear signaling by ERBB4;Chaperone Mediated Autophagy	PE1	17
+NX_P14138	Endothelin-3	238	25454	6.24	0	Secreted	Hirschsprung disease 4;Waardenburg syndrome 4B;Congenital central hypoventilation syndrome	Endothelins are endothelium-derived vasoconstrictor peptides.	NA	Belongs to the endothelin/sarafotoxin family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	20
+NX_P14151	L-selectin	372	42187	6.2	1	Cytosol;Cell membrane	NA	Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).	N-glycosylated.	Belongs to the selectin/LECAM family.	Cell adhesion molecules (CAMs);Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall;Neutrophil degranulation	PE1	1
+NX_P14174	Macrophage migration inhibitory factor	115	12476	7.73	0	Nucleoplasm;Cytosol;Cytoplasm;Secreted	Rheumatoid arthritis systemic juvenile	Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.	NA	Belongs to the MIF family.	Tyrosine metabolism;Phenylalanine metabolism;Cell surface interactions at the vascular wall;Neutrophil degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	22
+NX_P14207	Folate receptor beta	255	29280	7.5	0	Secreted;Cell membrane	NA	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.	N-glycosylated.	Belongs to the folate receptor family.	Endocytosis;Metabolism of folate and pterines;Post-translational modification: synthesis of GPI-anchored proteins	PE1	11
+NX_P14209	CD99 antigen	185	18848	4.58	1	Membrane;Golgi apparatus	NA	Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).	Extensively O-glycosylated.	Belongs to the CD99 family.	Cell adhesion molecules (CAMs);Leukocyte transendothelial migration;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall	PE1	X
+NX_P14210	Hepatocyte growth factor	728	83134	8.22	0	Cytosol;Centrosome	Deafness, autosomal recessive, 39	Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.	NA	Belongs to the peptidase S1 family. Plasminogen subfamily.	Cytokine-cytokine receptor interaction;Focal adhesion;Malaria;Pathways in cancer;Renal cell carcinoma;Melanoma;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Interleukin-7 signaling;Platelet degranulation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Negative regulation of MET activity;MET activates PTK2 signaling;MET interacts with TNS proteins;MET activates RAS signaling;MET activates RAP1 and RAC1;MET activates PI3K/AKT signaling;MET activates PTPN11;MET receptor recycling;MET Receptor Activation;MET activates STAT3;Interleukin-4 and Interleukin-13 signaling	PE1	7
+NX_P14222	Perforin-1	555	61377	8.04	0	Cell membrane;Cytoplasmic granule lumen;Secreted;Endosome lumen;Cytosol	Familial hemophagocytic lymphohistiocytosis 2	Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. In transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.	N-glycosylated.	Belongs to the complement C6/C7/C8/C9 family.	Natural killer cell mediated cytotoxicity;Type I diabetes mellitus;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;Viral myocarditis	PE1	10
+NX_P14314	Glucosidase 2 subunit beta	528	59425	4.33	0	Endoplasmic reticulum	Polycystic liver disease 1 with or without kidney cysts	Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).	NA	NA	Glycan metabolism; N-glycan metabolism.;Protein processing in endoplasmic reticulum;Advanced glycosylation endproduct receptor signaling;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Calnexin/calreticulin cycle;Post-translational protein phosphorylation	PE1	19
+NX_P14316	Interferon regulatory factor 2	349	39354	7.07	0	Nucleoplasm;Cytosol;Cell junction;Nucleus	NA	Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.	The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.;Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.	Belongs to the IRF family.	Factors involved in megakaryocyte development and platelet production;Interferon gamma signaling;Interferon alpha/beta signaling	PE1	4
+NX_P14317	Hematopoietic lineage cell-specific protein	486	54014	4.74	0	Cytoplasm;Mitochondrion;Cell membrane;Membrane;Cytosol	NA	Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.	Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES.	NA	Tight junction;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis	PE1	3
+NX_P14324	Farnesyl pyrophosphate synthase	419	48275	5.83	0	Nucleoplasm;Cytosol;Cytoplasm	Porokeratosis 9, multiple types	Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.	NA	Belongs to the FPP/GGPP synthase family.	Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.;Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.;Terpenoid backbone biosynthesis;Metabolic pathways;Influenza A;HTLV-I infection;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	1
+NX_P14373	Zinc finger protein RFP	513	58490	5.83	0	Cytoplasm;Early endosome;Nucleolus;Nucleoplasm;PML body;Nucleus	NA	E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.	NA	Belongs to the TRIM/RBCC family.	Regulation of PTEN stability and activity;SUMOylation of ubiquitinylation proteins	PE1	6
+NX_P14384	Carboxypeptidase M	443	50514	6.94	0	Cytoplasmic vesicle;Cell membrane	NA	Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.	NA	Belongs to the peptidase M14 family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	12
+NX_P14406	Cytochrome c oxidase subunit 7A2, mitochondrial	83	9396	9.75	0	Mitochondrion inner membrane;Mitochondrion;Cell membrane	NA	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase VIIa family.	Oxidative phosphorylation;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease	PE1	6
+NX_P14410	Sucrase-isomaltase, intestinal	1827	209453	5.38	1	Apical cell membrane	Congenital sucrase-isomaltase deficiency	Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides.	Sulfated.;The precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen.	Belongs to the glycosyl hydrolase 31 family.	Galactose metabolism;Starch and sucrose metabolism;Metabolic pathways;Carbohydrate digestion and absorption;Digestion of dietary carbohydrate;Intestinal saccharidase deficiencies	PE1	3
+NX_P14415	Sodium/potassium-transporting ATPase subunit beta-2	290	33367	8.57	1	Cell membrane	NA	Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.;This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.	NA	Belongs to the X(+)/potassium ATPases subunit beta family.	Cardiac muscle contraction;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Protein digestion and absorption;Bile secretion;Mineral absorption;Ion transport by P-type ATPases;Basigin interactions;Ion homeostasis	PE1	17
+NX_P14416	D(2) dopamine receptor	443	50619	9.55	7	Cell membrane	NA	Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Gap junction;Dopaminergic synapse;G alpha (i) signalling events;Dopamine receptors	PE1	11
+NX_P14543	Nidogen-1	1247	136377	5.12	0	Basement membrane	NA	Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.	N- and O-glycosylated.	NA	Degradation of the extracellular matrix;Laminin interactions	PE1	1
+NX_P14550	Aldo-keto reductase family 1 member A1	325	36573	6.32	0	Nucleoplasm;Apical cell membrane;Cytosol	NA	Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:18276838, PubMed:11306097). Displays no reductase activity towards retinoids (By similarity).	NA	Belongs to the aldo/keto reductase family.	Glycolysis / Gluconeogenesis;Glycerolipid metabolism;Metabolic pathways;Glutathione conjugation;Formation of xylulose-5-phosphate	PE1	1
+NX_P14555	Phospholipase A2, membrane associated	144	16083	9.44	0	Endoplasmic reticulum;Secreted;Cell membrane	NA	Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536).	NA	Belongs to the phospholipase A2 family.	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Antimicrobial peptides	PE1	1
+NX_P14598	Neutrophil cytosol factor 1	390	44682	9.2	0	Membrane;Cytosol	Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).	Phosphorylated by PRKCD; phosphorylation induces activation of NCF1 and NADPH oxidase activity.;NCF1 is phosphorylated by PRKCZ (Phosphoserine:PTM-0253)	NA	Chemokine signaling pathway;Phagosome;Osteoclast differentiation;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Leishmaniasis;Detoxification of Reactive Oxygen Species;VEGFA-VEGFR2 Pathway;ROS and RNS production in phagocytes;Cross-presentation of particulate exogenous antigens (phagosomes);RHO GTPases Activate NADPH Oxidases	PE1	7
+NX_P14616	Insulin receptor-related protein	1297	143720	6.03	1	Membrane	NA	Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.	Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	Regulation of actin cytoskeleton;Prostate cancer	PE1	1
+NX_P14618	Pyruvate kinase PKM	531	57937	7.96	0	Cytoplasm;Cytosol;Nucleus	NA	Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:17308100, PubMed:18191611, PubMed:21620138). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity).	ISGylated.;FGFR1-dependent tyrosine phosphorylation is reduced by interaction with TRIM35.;Under hypoxia, hydroxylated by EGLN3.;Acetylation at Lys-305 is stimulated by high glucose concentration, it decreases enzyme activity and promotes its lysosomal-dependent degradation via chaperone-mediated autophagy.	Belongs to the pyruvate kinase family.	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.;Glycolysis / Gluconeogenesis;Purine metabolism;Pyruvate metabolism;Metabolic pathways;Type II diabetes mellitus;Glycolysis;Neutrophil degranulation	PE1	15
+NX_P14621	Acylphosphatase-2	99	11140	9.52	0	Nucleoplasm;Cytoplasm	NA	Its physiological role is not yet clear.	NA	Belongs to the acylphosphatase family.	Pyruvate metabolism	PE1	2
+NX_P14625	Endoplasmin	803	92469	4.76	0	Endoplasmic reticulum;Endoplasmic reticulum lumen;Melanosome;Sarcoplasmic reticulum lumen	NA	Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity).	NA	Belongs to the heat shock protein 90 family.	Protein processing in endoplasmic reticulum;NOD-like receptor signaling pathway;Pathways in cancer;Prostate cancer;Trafficking and processing of endosomal TLR;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Scavenging by Class A Receptors;ATF6 (ATF6-alpha) activates chaperone genes;Interleukin-4 and Interleukin-13 signaling;Post-translational protein phosphorylation	PE1	12
+NX_P14635	G2/mitotic-specific cyclin-B1	433	48337	7.09	0	Cytoplasm;Cytosol;Centrosome;Nucleus	NA	Essential for the control of the cell cycle at the G2/M (mitosis) transition.	Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.;Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.	Belongs to the cyclin family. Cyclin AB subfamily.	Cell cycle;Oocyte meiosis;p53 signaling pathway;Progesterone-mediated oocyte maturation;Nuclear Pore Complex (NPC) Disassembly;Activation of NIMA Kinases NEK9, NEK6, NEK7;Regulation of PLK1 Activity at G2/M Transition;Resolution of Sister Chromatid Cohesion;Condensation of Prophase Chromosomes;Polo-like kinase mediated events;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;MASTL Facilitates Mitotic Progression;APC/C:Cdc20 mediated degradation of Cyclin B;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of the APC/C;E2F-enabled inhibition of pre-replication complex formation;Phosphorylation of Emi1;Golgi Cisternae Pericentriolar Stack Reorganization;Condensation of Prometaphase Chromosomes;Depolymerisation of the Nuclear Lamina;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;The role of GTSE1 in G2/M progression after G2 checkpoint;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Transcriptional regulation by RUNX2;Mitotic Prophase	PE1	5
+NX_P14649	Myosin light chain 6B	208	22764	5.56	0	Cytoplasmic vesicle	NA	Regulatory light chain of myosin. Does not bind calcium.	NA	NA	Vascular smooth muscle contraction;Smooth Muscle Contraction	PE1	12
+NX_P14651	Homeobox protein Hox-B3	431	44340	9.27	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	17
+NX_P14652	Homeobox protein Hox-B2	356	37914	5.03	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family. Proboscipedia subfamily.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	17
+NX_P14653	Homeobox protein Hox-B1	301	32193	6.45	0	Nucleus	Facial paresis, hereditary congenital, 3	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.	NA	Belongs to the Antp homeobox family. Labial subfamily.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	17
+NX_P14672	Solute carrier family 2, facilitated glucose transporter member 4	509	54787	6.48	12	Endomembrane system;Perinuclear region;Cell membrane	Diabetes mellitus, non-insulin-dependent	Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.	Sumoylated.	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Insulin signaling pathway;Adipocytokine signaling pathway;Type II diabetes mellitus;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Transcriptional regulation of white adipocyte differentiation;Cellular hexose transport	PE1	17
+NX_P14678	Small nuclear ribonucleoprotein-associated proteins B and B'	240	24610	11.2	0	Cytosol;Nucleus	Cerebrocostomandibular syndrome	Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:12975319).	Methylated. Arg-108 and Arg-112 are dimethylated, probably to asymmetric dimethylarginine.	Belongs to the snRNP SmB/SmN family.	Spliceosome;Systemic lupus erythematosus;snRNP Assembly;SLBP independent Processing of Histone Pre-mRNAs;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	20
+NX_P14679	Tyrosinase	529	60393	5.71	1	Cytoplasmic vesicle;Melanosome;Melanosome membrane	Albinism, oculocutaneous, 1B;Albinism, oculocutaneous, 1A	This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.	Glycosylated.	Belongs to the tyrosinase family.	Tyrosine metabolism;Riboflavin metabolism;Metabolic pathways;Melanogenesis;Melanin biosynthesis	PE1	11
+NX_P14735	Insulin-degrading enzyme	1019	117968	6.16	0	Cytosol;Secreted;Cell membrane	NA	(Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV).;Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:2293021, PubMed:10684867, PubMed:26968463, PubMed:17051221, PubMed:17613531, PubMed:18986166, PubMed:19321446, PubMed:23922390, PubMed:24847884, PubMed:26394692, PubMed:29596046). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed:23922390, PubMed:26394692, PubMed:29596046). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (PubMed:9830016, PubMed:26394692) (Probable). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I.	The N-terminus is blocked.	Belongs to the peptidase M16 family.	Alzheimer's disease;Ub-specific processing proteases;Peroxisomal protein import	PE1	10
+NX_P14770	Platelet glycoprotein IX	177	19046	5.89	1	Membrane	Bernard-Soulier syndrome	The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.	NA	NA	ECM-receptor interaction;Hematopoietic cell lineage;Platelet Adhesion to exposed collagen;Intrinsic Pathway of Fibrin Clot Formation;GP1b-IX-V activation signalling;Platelet Aggregation (Plug Formation)	PE1	3
+NX_P14778	Interleukin-1 receptor type 1	569	65402	8	1	Cell membrane;Secreted;Membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).	A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).;Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.	Belongs to the interleukin-1 receptor family.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Apoptosis;Osteoclast differentiation;Hematopoietic cell lineage;Amoebiasis;HTLV-I infection;Interleukin-10 signaling;Interleukin-1 signaling	PE1	2
+NX_P14780	Matrix metalloproteinase-9	707	78458	5.69	0	Cytosol;Extracellular matrix	Intervertebral disc disease;Metaphyseal anadysplasia 2	May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.	N- and O-glycosylated.;Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.	Belongs to the peptidase M10A family.	Leukocyte transendothelial migration;Pathways in cancer;Bladder cancer;Degradation of the extracellular matrix;EPH-ephrin mediated repulsion of cells;Collagen degradation;Signaling by SCF-KIT;Assembly of collagen fibrils and other multimeric structures;Activation of Matrix Metalloproteinases;Neutrophil degranulation;Interleukin-4 and Interleukin-13 signaling;Extra-nuclear estrogen signaling	PE1	20
+NX_P14784	Interleukin-2 receptor subunit beta	551	61117	4.93	1	Cell surface;Cell membrane	NA	Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770).	NA	Belongs to the type I cytokine receptor family. Type 4 subfamily.	Cytokine-cytokine receptor interaction;Endocytosis;Jak-STAT signaling pathway;Measles;HTLV-I infection;RAF/MAP kinase cascade;Interleukin receptor SHC signaling;Interleukin-15 signaling;Interleukin-2 signaling	PE1	22
+NX_P14854	Cytochrome c oxidase subunit 6B1	86	10192	6.54	0	Mitochondrion intermembrane space;Mitochondrion	Mitochondrial complex IV deficiency	Connects the two COX monomers into the physiological dimeric form.	NA	Belongs to the cytochrome c oxidase subunit 6B family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	19
+NX_P14859	POU domain, class 2, transcription factor 1	743	76472	6.34	0	Endoplasmic reticulum;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.	Phosphorylated by PRKDC.	Belongs to the POU transcription factor family. Class-2 subfamily.	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA polymerase II transcribes snRNA genes;Interleukin-4 and Interleukin-13 signaling;Estrogen-dependent gene expression	PE1	1
+NX_P14866	Heterogeneous nuclear ribonucleoprotein L	589	64133	8.46	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897).	Several isoelectric forms of the L protein are probably the results of post-translational modifications.;Phosphorylation at Ser-544 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization.	NA	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA	PE1	19
+NX_P14867	Gamma-aminobutyric acid receptor subunit alpha-1	456	51802	9.27	4	Cytoplasmic vesicle membrane;Cell membrane;Postsynaptic cell membrane	Epileptic encephalopathy, early infantile, 19;Juvenile myoclonic epilepsy 5;Epilepsy, childhood absence 4;Epilepsy, idiopathic generalized 13	Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).	Glycosylated.	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;Signaling by ERBB4;GABA receptor activation	PE1	5
+NX_P14868	Aspartate--tRNA ligase, cytoplasmic	501	57136	6.11	0	Cytosol	Hypomyelination with brainstem and spinal cord involvement and leg spasticity	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.	NA	Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation;Selenoamino acid metabolism	PE1	2
+NX_P14902	Indoleamine 2,3-dioxygenase 1	403	45326	6.87	0	Nucleoplasm;Cytosol;Mitochondrion;Cytoplasmic vesicle	NA	Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885).	NA	Belongs to the indoleamine 2,3-dioxygenase family.	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.;Tryptophan metabolism;Metabolic pathways;African trypanosomiasis;Tryptophan catabolism	PE1	8
+NX_P14920	D-amino-acid oxidase	347	39474	6.36	0	Peroxisome	Schizophrenia	Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.	NA	Belongs to the DAMOX/DASOX family.	Glycine, serine and threonine metabolism;Arginine and proline metabolism;D-Arginine and D-ornithine metabolism;Metabolic pathways;Peroxisome;Glyoxylate metabolism and glycine degradation;Peroxisomal protein import	PE1	12
+NX_P14921	Protein C-ets-1	441	50408	5.04	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.	Ubiquitinated; which induces proteasomal degradation.;Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.	Belongs to the ETS family.	Dorso-ventral axis formation;HTLV-I infection;Pathways in cancer;Renal cell carcinoma;Oncogene Induced Senescence	PE1	11
+NX_P14923	Junction plakoglobin	745	81745	5.75	0	Desmosome;Cell membrane;Adherens junction;Cell junction;Membrane;Cytoplasmic vesicle;Cytoskeleton	Arrhythmogenic right ventricular dysplasia, familial, 12;Naxos disease	Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).	May be phosphorylated by FER.;JUP is phosphorylated by EGFR (Phosphotyrosine:PTM-0255)	Belongs to the beta-catenin family.	Pathways in cancer;Acute myeloid leukemia;Arrhythmogenic right ventricular cardiomyopathy (ARVC);VEGFR2 mediated vascular permeability;Adherens junctions interactions;Neutrophil degranulation;Formation of the cornified envelope;Keratinization	PE1	17
+NX_P14927	Cytochrome b-c1 complex subunit 7	111	13530	8.73	0	Cytoplasm;Mitochondrion inner membrane;Mitochondrion;Nucleus	Mitochondrial complex III deficiency, nuclear 3	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.	NA	Belongs to the UQCRB/QCR7 family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport	PE1	8
+NX_P15018	Leukemia inhibitory factor	202	22008	9.44	0	Cytosol;Secreted	NA	LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.	NA	Belongs to the LIF/OSM family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;IL-6-type cytokine receptor ligand interactions;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling	PE1	22
+NX_P15036	Protein C-ets-2	469	53001	4.93	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.	Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.	Belongs to the ETS family.	Dorso-ventral axis formation;HTLV-I infection;Oncogene Induced Senescence	PE1	21
+NX_P15056	Serine/threonine-protein kinase B-raf	766	84437	7.29	0	Cytoplasm;Cell membrane;Cytoplasmic vesicle;Cytosol;Nucleus	LEOPARD syndrome 3;Cardiofaciocutaneous syndrome 1;Lung cancer;Noonan syndrome 7;Familial non-Hodgkin lymphoma;Colorectal cancer	Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179).	Methylation at Arg-671 decreases stability and kinase activity.;Ubiquitinated by RNF149; which leads to proteasomal degradation. Polyubiquitinated at Lys-578 in response to EGF.;Phosphorylation at Ser-365 by SGK1 inhibits its activity.	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;mTOR signaling pathway;Vascular smooth muscle contraction;Focal adhesion;Natural killer cell mediated cytotoxicity;Long-term potentiation;Neurotrophin signaling pathway;Long-term depression;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Hepatitis C;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Negative regulation of MAPK pathway;Signalling to p38 via RIT and RIN;RAF activation;MAP2K and MAPK activation;ARMS-mediated activation;Spry regulation of FGF signaling;Frs2-mediated activation;Negative feedback regulation of MAPK pathway;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	7
+NX_P15085	Carboxypeptidase A1	419	47140	5.45	0	Secreted	NA	Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.	NA	Belongs to the peptidase M14 family.	Pancreatic secretion;Protein digestion and absorption	PE1	7
+NX_P15086	Carboxypeptidase B	417	47368	6.16	0	Secreted	NA	NA	NA	Belongs to the peptidase M14 family.	Pancreatic secretion;Protein digestion and absorption;Metabolism of Angiotensinogen to Angiotensins	PE1	3
+NX_P15088	Mast cell carboxypeptidase A	417	48670	9.08	0	Golgi apparatus;Nucleoplasm;Secretory vesicle	NA	NA	NA	Belongs to the peptidase M14 family.	Renin-angiotensin system;Pancreatic secretion;Protein digestion and absorption;Metabolism of Angiotensinogen to Angiotensins	PE1	3
+NX_P15090	Fatty acid-binding protein, adipocyte	132	14719	6.59	0	Cytoplasm;Nucleus	NA	Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	PPAR signaling pathway;Triglyceride catabolism;Transcriptional regulation of white adipocyte differentiation	PE1	8
+NX_P15104	Glutamine synthetase	373	42064	6.43	0	Cytosol;Mitochondrion;Microsome;Cell membrane	Congenital systemic glutamine deficiency	Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351).	Palmitoylated; undergoes autopalmitoylation.;Ubiquitinated by ZNRF1.	Belongs to the glutamine synthetase family.	Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;Nitrogen metabolism;Metabolic pathways;Glutamatergic synapse;GABAergic synapse;Astrocytic Glutamate-Glutamine Uptake And Metabolism;Glutamate and glutamine metabolism	PE1	1
+NX_P15121	Aldo-keto reductase family 1 member B1	316	35853	6.51	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684).	NA	Belongs to the aldo/keto reductase family.	Pentose and glucuronate interconversions;Fructose and mannose metabolism;Galactose metabolism;Glycerolipid metabolism;Pyruvate metabolism;Metabolic pathways;Pregnenolone biosynthesis;Fructose biosynthesis	PE1	7
+NX_P15144	Aminopeptidase N	967	109540	5.31	1	Cell membrane	NA	(Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein.;Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).;(Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.	Sulfated.;N- and O-glycosylated.;May undergo proteolysis and give rise to a soluble form.	Belongs to the peptidase M1 family.	Glutathione metabolism;Metabolic pathways;Renin-angiotensin system;Hematopoietic cell lineage;Metabolism of Angiotensinogen to Angiotensins;Neutrophil degranulation	PE1	15
+NX_P15151	Poliovirus receptor	417	45303	6.07	1	Cytoplasmic vesicle;Nucleoplasm;Secreted;Cell membrane	NA	(Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.;(Microbial infection) Acts as a receptor for Pseudorabies virus.;(Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.;Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.	Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation.;N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4.	Belongs to the nectin family.	Cell adhesion molecules (CAMs);Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Nectin/Necl trans heterodimerization	PE1	19
+NX_P15153	Ras-related C3 botulinum toxin substrate 2	192	21429	7.52	0	Cytoplasm	Neutrophil immunodeficiency syndrome	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.	(Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.	Belongs to the small GTPase superfamily. Rho family.	MAPK signaling pathway;Chemokine signaling pathway;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Focal adhesion;Adherens junction;Natural killer cell mediated cytotoxicity;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Viral myocarditis;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;GPVI-mediated activation cascade;Rho GTPase cycle;ROS and RNS production in phagocytes;PCP/CE pathway;RHO GTPases Activate NADPH Oxidases;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	22
+NX_P15169	Carboxypeptidase N catalytic chain	458	52286	6.86	0	Extracellular space	Carboxypeptidase N deficiency	Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.	NA	Belongs to the peptidase M14 family.	Regulation of Complement cascade	PE1	10
+NX_P15170	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A	499	55756	5.45	0	Cytoplasm	NA	Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.	mRNA surveillance pathway;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs	PE1	16
+NX_P15172	Myoblast determination protein 1	320	34501	5.56	0	Nucleoplasm;Nucleus	NA	Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity.;Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).;Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.;Ubiquitinated on the N-terminus; which is required for proteasomal degradation.;MYOD1 is phosphorylated by CDK9	NA	Myogenesis	PE1	11
+NX_P15173	Myogenin	224	25037	5.45	0	Nucleoplasm;Nucleus	NA	Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).	Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By similarity).	NA	Myogenesis	PE1	1
+NX_P15248	Interleukin-9	144	15909	8.93	0	Secreted	NA	Supports IL-2 independent and IL-4 independent growth of helper T-cells.	NA	Belongs to the IL-7/IL-9 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Asthma;Interleukin-9 signaling	PE2	5
+NX_P15259	Phosphoglycerate mutase 2	253	28766	8.99	0	Nucleoplasm;Cytosol;Nucleolus	Glycogen storage disease 10	Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.	NA	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.	Glycolysis / Gluconeogenesis;Metabolic pathways;Glycolysis;Gluconeogenesis	PE1	7
+NX_P15260	Interferon gamma receptor 1	489	54405	4.83	1	Cell membrane	Immunodeficiency 27A;Immunodeficiency 27B	Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550).	Phosphorylated at Ser/Thr residues.	Belongs to the type II cytokine receptor family.	Cytokine-cytokine receptor interaction;Osteoclast differentiation;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Salmonella infection;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Measles;Influenza A;Herpes simplex infection;Interferon gamma signaling;Regulation of IFNG signaling	PE1	6
+NX_P15289	Arylsulfatase A	507	53588	5.65	0	Golgi apparatus;Endoplasmic reticulum;Cytosol;Lysosome	Metachromatic leukodystrophy;Multiple sulfatase deficiency	Hydrolyzes cerebroside sulfate.	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD).	Belongs to the sulfatase family.	Sphingolipid metabolism;Lysosome;Glycosphingolipid metabolism;The activation of arylsulfatases;Neutrophil degranulation	PE1	22
+NX_P15291	Beta-1,4-galactosyltransferase 1	398	43920	8.88	1	Golgi apparatus;Cell membrane;Secreted;Cell surface;Golgi stack membrane;Filopodium	Congenital disorder of glycosylation 2D	The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.;The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.	The soluble form derives from the membrane forms by proteolytic processing.	Belongs to the glycosyltransferase 7 family.	Protein modification; protein glycosylation.;Galactose metabolism;N-Glycan biosynthesis;Other types of O-glycan biosynthesis;Glycosaminoglycan biosynthesis - keratan sulfate;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Keratan sulfate biosynthesis;Defective B4GALT1 causes B4GALT1-CDG (CDG-2d);Pre-NOTCH Processing in Golgi;N-Glycan antennae elongation;Lactose synthesis;Defective B4GALT1 causes B4GALT1-CDG (CDG-2d);Interaction With Cumulus Cells And The Zona Pellucida;Neutrophil degranulation	PE1	9
+NX_P15309	Prostatic acid phosphatase	386	44566	5.83	0	Lysosome membrane;Secreted;Cell membrane	NA	A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.;The cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.	Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.;N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.	Belongs to the histidine acid phosphatase family.	Riboflavin metabolism;Neutrophil degranulation	PE1	3
+NX_P15311	Ezrin	586	69413	5.94	0	Cell cortex;Cell membrane;Cell projection;Microvillus membrane;Ruffle membrane;Apical cell membrane;Microvillus;Cytoskeleton	NA	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.	Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).;S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.	NA	Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Gastric acid secretion;Pathogenic Escherichia coli infection;Netrin-1 signaling;Recycling pathway of L1	PE1	6
+NX_P15313	V-type proton ATPase subunit B, kidney isoform	513	56833	5.44	0	Nucleoplasm;Endomembrane system;Nucleus membrane	Renal tubular acidosis, distal, with progressive nerve deafness	Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	NA	Belongs to the ATPase alpha/beta chains family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	2
+NX_P15328	Folate receptor alpha	257	29819	8.3	0	Clathrin-coated vesicle;Cell membrane;Secreted;Nucleus membrane;Endosome;Cytoplasmic vesicle;Apical cell membrane	Neurodegeneration due to cerebral folate transport deficiency	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.	The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.	Belongs to the folate receptor family.	Endocytosis;COPII-mediated vesicle transport;Cargo concentration in the ER;COPI-mediated anterograde transport	PE1	11
+NX_P15336	Cyclic AMP-dependent transcription factor ATF-2	505	54537	7.75	0	Mitochondrion outer membrane;Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.	Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4. ATM-mediated phosphorylation at Ser-490 and Ser-498 stimulates its function in DNA damage response. Phosphorylation at Ser-62, Thr-73 and Ser-121 activates its transcriptional activity. Phosphorylation at Thr-69 or Thr-71 enhances its histone acetyltransferase (HAT) activity.;ATF2 is phosphorylated by MAPK11 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);ATF2 is phosphorylated by MAPK12 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);ATF2 is phosphorylated by MAPK13 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);ATF2 is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the bZIP family. ATF subfamily.	MAPK signaling pathway;Dopaminergic synapse;Influenza A;HTLV-I infection;HATs acetylate histones;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Activation of the AP-1 family of transcription factors;TP53 Regulates Transcription of DNA Repair Genes;Regulation of PTEN gene transcription;Estrogen-dependent gene expression	PE1	2
+NX_P15374	Ubiquitin carboxyl-terminal hydrolase isozyme L3	230	26183	4.84	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.	NA	Belongs to the peptidase C12 family.	UCH proteinases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Neddylation	PE1	13
+NX_P15382	Potassium voltage-gated channel subfamily E member 1	129	14675	6.83	1	Apical cell membrane;Membrane raft;Cell membrane	Jervell and Lange-Nielsen syndrome 2;Long QT syndrome 5	Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).	N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.;Phosphorylation inhibits the potassium current.	Belongs to the potassium channel KCNE family.	Phase 3 - rapid repolarisation;Phase 2 - plateau phase	PE1	21
+NX_P15391	B-lymphocyte antigen CD19	556	61128	4.87	1	Membrane raft;Cell membrane	Immunodeficiency, common variable, 3	Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:9382888, PubMed:9317126, PubMed:12387743, PubMed:16672701). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:2463100, PubMed:1373518). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:9317126, PubMed:12387743, PubMed:16672701).	Phosphorylated on tyrosine following B-cell activation (PubMed:7684160, PubMed:7687539, PubMed:10706702, PubMed:12387743). Phosphorylated on tyrosine residues by LYN (PubMed:7687428). Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels (By similarity).	NA	Hematopoietic cell lineage;B cell receptor signaling pathway;Primary immunodeficiency;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	16
+NX_P15407	Fos-related antigen 1	271	29413	8.21	0	Cytoplasm;Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the bZIP family. Fos subfamily.	Wnt signaling pathway;Osteoclast differentiation;HTLV-I infection	PE1	11
+NX_P15408	Fos-related antigen 2	326	35193	7.03	0	Nucleoplasm;Nucleus	NA	Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.	NA	Belongs to the bZIP family. Fos subfamily.	Osteoclast differentiation	PE1	2
+NX_P15421	Glycophorin-E	78	8463	9.51	1	Membrane	NA	This protein is a minor sialoglycoprotein in human erythrocyte membranes.	The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.	Belongs to the glycophorin-A family.	NA	PE2	4
+NX_P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	266	28977	5.56	0	Nucleoplasm;Cytosol;Cytoplasm	Hypertrophic osteoarthropathy, primary, autosomal recessive, 1;Cranioosteoarthropathy;Isolated congenital nail clubbing	Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Synthesis of Lipoxins (LX);Biosynthesis of D-series resolvins;Biosynthesis of E-series 18(S)-resolvins	PE1	4
+NX_P15498	Proto-oncogene vav	845	98314	6.2	0	Cytosol	NA	Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.	Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity). Phosphorylated by FYN.;VAV1 is phosphorylated by FYN (Phosphotyrosine:PTM-0255);VAV1 is phosphorylated by HCK (Phosphotyrosine:PTM-0255);VAV1 is phosphorylated by INSR (Phosphotyrosine:PTM-0255);VAV1 is phosphorylated by MERTK (Phosphotyrosine:PTM-0255)	NA	Chemokine signaling pathway;Focal adhesion;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Regulation of actin dynamics for phagocytic cup formation;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;GPVI-mediated activation cascade;Rho GTPase cycle;NRAGE signals death through JNK;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;G alpha (12/13) signalling events;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Signaling by SCF-KIT;CD28 dependent Vav1 pathway;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Interleukin-3, Interleukin-5 and GM-CSF signaling;Regulation of signaling by CBL;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Erythropoietin activates RAS	PE1	19
+NX_P15502	Elastin	786	68398	10.4	0	Extracellular matrix;Mitochondrion;Cell membrane	Supravalvular aortic stenosis;Cutis laxa, autosomal dominant, 1	Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).	Hydroxylation on proline residues within the sequence motif, GXPG, is most likely 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.;Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine.	Belongs to the elastin family.	Protein digestion and absorption;Degradation of the extracellular matrix;Molecules associated with elastic fibres;Elastic fibre formation	PE1	7
+NX_P15509	Granulocyte-macrophage colony-stimulating factor receptor subunit alpha	400	46207	7.91	1	Secreted;Cell membrane	Pulmonary surfactant metabolism dysfunction 4	Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.	NA	Belongs to the type I cytokine receptor family. Type 5 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Pathways in cancer;RAF/MAP kinase cascade;Interleukin receptor SHC signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling;Surfactant metabolism;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	PE1	X
+NX_P15514	Amphiregulin	252	27895	7.01	1	Membrane;Mitochondrion	NA	Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.	NA	Belongs to the amphiregulin family.	ErbB signaling pathway;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;EGFR downregulation;Signaling by EGFR;COPII-mediated vesicle transport;GAB1 signalosome;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;EGFR interacts with phospholipase C-gamma;Inhibition of Signaling by Overexpressed EGFR;Cargo concentration in the ER;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Extra-nuclear estrogen signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	4
+NX_P15515	Histatin-1	57	6963	9.1	0	Secreted	NA	Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.	Depending on the authors, the form called histatin-2 is alternatively a proteolytic product, or the non-phosphorylated form of histatin-1.	Belongs to the histatin/statherin family.	Salivary secretion;Antimicrobial peptides	PE1	4
+NX_P15516	Histatin-3	51	6149	10.09	0	Secreted	NA	Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.	24 proteolytic products are found in saliva.	Belongs to the histatin/statherin family.	Antimicrobial peptides	PE1	4
+NX_P15529	Membrane cofactor protein	392	43747	6.34	1	Acrosome inner membrane;Cell membrane	Hemolytic uremic syndrome atypical 2	(Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6.;Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.;(Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3.;(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).;(Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.;(Microbial infection) Acts as a receptor for cultured Measles virus.	In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae; which promotes infectivity. In T-cells, these isoforms may be phosphorylated by LCK.;N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding.;Extensively O-glycosylated in the Ser/Thr-rich domain. O-glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding.	NA	Complement and coagulation cascades;Measles;Regulation of Complement cascade	PE1	1
+NX_P15531	Nucleoside diphosphate kinase A	152	17149	5.83	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.	NA	Belongs to the NDK family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	17
+NX_P15538	Cytochrome P450 11B1, mitochondrial	503	57573	9.4	0	Mitochondrion inner membrane	Adrenal hyperplasia 4;Hyperaldosteronism, familial, 1	A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed:18215163). Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively (PubMed:18215163). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:18215163).	NA	Belongs to the cytochrome P450 family.	Steroid biosynthesis; glucocorticoid biosynthesis.;Steroid hormone biosynthesis.;Steroid hormone biosynthesis;Metabolic pathways;Endogenous sterols;Glucocorticoid biosynthesis;Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)	PE1	8
+NX_P15559	NAD(P)H dehydrogenase [quinone] 1	274	30868	8.91	0	Cytoplasm;Cytosol	NA	The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.	NA	Belongs to the NAD(P)H dehydrogenase (quinone) family.	Regulation of ornithine decarboxylase (ODC)	PE1	16
+NX_P15586	N-acetylglucosamine-6-sulfatase	552	62082	8.6	0	Lysosome	Mucopolysaccharidosis 3D	NA	The form A (78 kDa) is processed by internal peptidase cleavage to a 32 kDa N-terminal species (form B) and a 48 kDa C-terminal species.;The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Glycosaminoglycan degradation;Metabolic pathways;Lysosome;Keratan sulfate degradation;Lysosome Vesicle Biogenesis;MPS IIID - Sanfilippo syndrome D;Neutrophil degranulation	PE1	12
+NX_P15621	Zinc finger protein 44	663	76524	9	0	Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P15622	Zinc finger protein 250	560	63468	8.65	0	Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	8
+NX_P15692	Vascular endothelial growth factor A	232	27042	9.21	0	Secreted	Microvascular complications of diabetes 1	Binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).;Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145.	NA	Belongs to the PDGF/VEGF growth factor family.	Cytokine-cytokine receptor interaction;mTOR signaling pathway;VEGF signaling pathway;Focal adhesion;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Bladder cancer;Rheumatoid arthritis;VEGFA-VEGFR2 Pathway;Regulation of gene expression by Hypoxia-inducible Factor;Platelet degranulation;VEGFR2 mediated cell proliferation;VEGF ligand-receptor interactions;VEGF binds to VEGFR leading to receptor dimerization;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;Interleukin-4 and Interleukin-13 signaling	PE1	6
+NX_P15735	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	406	46442	5.95	0	Cytosol	Glycogen storage disease 9C	Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	Calcium signaling pathway;Insulin signaling pathway;Glycogen breakdown (glycogenolysis)	PE1	16
+NX_P15812	T-cell surface glycoprotein CD1e, membrane-associated	388	43626	8.87	1	Early endosome;Lysosome lumen;Late endosome;Golgi apparatus membrane	NA	T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.	Mono-ubiquitinated.;Proteolytically cleaved in late endosomes to yield a soluble form.	NA	Hematopoietic cell lineage	PE1	1
+NX_P15813	Antigen-presenting glycoprotein CD1d	335	37717	8.43	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;Basolateral cell membrane;Lysosome membrane;Endoplasmic reticulum	NA	Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.	NA	NA	Hematopoietic cell lineage;Amoebiasis;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	1
+NX_P15814	Immunoglobulin lambda-like polypeptide 1	213	22963	10.1	0	Endoplasmic reticulum;Secreted	Agammaglobulinemia 2, autosomal recessive	Critical for B-cell development.	NA	NA	Primary immunodeficiency;Cell surface interactions at the vascular wall	PE1	22
+NX_P15822	Zinc finger protein 40	2718	296865	7.98	0	Nucleoplasm;Cytoplasm;Mitochondrion;Nucleus	NA	May be involved in apoptosis.;Also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes.;This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression.;Does not activate HIV-1 gene expression.	NA	NA	NA	PE1	6
+NX_P15848	Arylsulfatase B	533	59687	8.43	0	Cell surface;Golgi apparatus;Lysosome	Multiple sulfatase deficiency;Mucopolysaccharidosis 6	Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD).	Belongs to the sulfatase family.	Glycosaminoglycan degradation;Metabolic pathways;Lysosome;Glycosphingolipid metabolism;CS/DS degradation;The activation of arylsulfatases;MPS VI - Maroteaux-Lamy syndrome;Neutrophil degranulation	PE1	5
+NX_P15863	Paired box protein Pax-1	534	55499	9.9	0	Nucleus	Otofaciocervical syndrome 2	This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity).	NA	NA	NA	PE1	20
+NX_P15880	40S ribosomal protein S2	293	31324	10.25	0	Endoplasmic reticulum;Cytoplasm;Cytosol	NA	NA	Citrullinated by PADI4 in the Arg/Gly-rich region.;Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.	Belongs to the universal ribosomal protein uS5 family.	Ribosome;RMTs methylate histone arginines;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Protein methylation;Regulation of expression of SLITs and ROBOs	PE1	16
+NX_P15882	N-chimaerin	459	53172	6.51	0	Cytosol	Duane retraction syndrome 2	GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.	Phosphorylated. Phosphorylation is EPHA4 kinase activity-dependent (By similarity).	NA	Rho GTPase cycle	PE1	2
+NX_P15884	Transcription factor 4	667	71308	6.51	0	Nucleoplasm;Cytosol;Nucleus	Corneal dystrophy, Fuchs endothelial, 3;Pitt-Hopkins syndrome	Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.	NA	NA	HTLV-I infection;Myogenesis	PE1	18
+NX_P15907	Beta-galactoside alpha-2,6-sialyltransferase 1	406	46605	9.13	1	Golgi stack membrane;Secreted	NA	Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.	The soluble form derives from the membrane form by proteolytic processing.;The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.;N-glycosylated.	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Other types of O-glycan biosynthesis;Metabolic pathways;Sialic acid metabolism;Termination of O-glycan biosynthesis;N-Glycan antennae elongation	PE1	3
+NX_P15918	V(D)J recombination-activating protein 1	1043	119097	8.94	0	Nucleoplasm;Nucleus	Omenn syndrome;Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-positive;Combined cellular and humoral immune defects with granulomas;Alpha/beta T-cell lymphopenia, with gamma/delta T-cell expansion, severe cytomegalovirus infection and autoimmunity	Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitination of KPNA1 (By similarity).	Autoubiquitinated in the presence of CDC34/UBCH3.	Belongs to the RAG1 family.	Primary immunodeficiency;MAPK6/MAPK4 signaling;Interleukin-7 signaling	PE1	11
+NX_P15923	Transcription factor E2-alpha	654	67600	6	0	Nucleoplasm;Nucleus	Agammaglobulinemia 8, autosomal dominant	Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.	Phosphorylated following NGF stimulation.;TCF3 is phosphorylated by MAPKAPK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	HTLV-I infection;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Myogenesis	PE1	19
+NX_P15924	Desmoplakin	2871	331774	6.44	0	Cell junction;Desmosome;Cell membrane;Cytoskeleton	Cardiomyopathy, dilated, with woolly hair and keratoderma;Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis;Epidermolysis bullosa, lethal acantholytic;Keratoderma, palmoplantar, striate 2;Skin fragility-woolly hair syndrome;Arrhythmogenic right ventricular dysplasia, familial, 8	Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.	Ser-2849 is probably phosphorylated by a cAMP-dependent protein kinase. Phosphorylation on Ser-2849 probably affects its association with epidermal, simple cytokeratins and VIM intermediate filaments.	Belongs to the plakin or cytolinker family.	Arrhythmogenic right ventricular cardiomyopathy (ARVC);Apoptotic cleavage of cell adhesion proteins;Neutrophil degranulation;Formation of the cornified envelope;Keratinization	PE1	6
+NX_P15927	Replication protein A 32 kDa subunit	270	29247	5.75	0	Nucleoplasm;PML body;Nucleus	NA	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.	DNA damage-induced 'Lys-63'-linked polyubiquitination by PRPF19 mediates ATRIP recruitment to the RPA complex at sites of DNA damage and activation of ATR (PubMed:24332808). Ubiquitinated by RFWD3 at stalled replication forks in response to DNA damage: ubiquitination by RFWD3 does not lead to degradation by the proteasome and promotes removal of the RPA complex from stalled replication forks, promoting homologous recombination (PubMed:26474068).;Differentially phosphorylated throughout the cell cycle, becoming phosphorylated at the G1-S transition and dephosphorylated in late mitosis. Mainly phosphorylated at Ser-23 and Ser-29, by cyclin A-CDK2 and cyclin B-CDK1, respectively during DNA replication and mitosis. Dephosphorylation may require the serine/threonine-protein phosphatase 4. Phosphorylation at Ser-23 and Ser-29 is a prerequisite for further phosphorylation. Becomes hyperphosphorylated on additional residues including Ser-4, Ser-8, Thr-21 and Ser-33 in response to DNA damage. Hyperphosphorylation is mediated by ATM, ATR and PRKDC. Primarily recruited to DNA repair nuclear foci as a hypophosphorylated form it undergoes subsequent hyperphosphorylation, catalyzed by ATR. Hyperphosphorylation is required for RAD51 recruitment to chromatin and efficient DNA repair. Phosphorylation at Thr-21 depends upon RFWD3 presence.	Belongs to the replication factor A protein 2 family.	DNA replication;Nucleotide excision repair;Mismatch repair;Homologous recombination;Fanconi anemia pathway;Regulation of HSF1-mediated heat shock response;Translesion Synthesis by POLH;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Meiotic recombination;Activation of ATR in response to replication stress;Activation of the pre-replicative complex;G2/M DNA damage checkpoint;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Removal of the Flap Intermediate from the C-strand;Removal of the Flap Intermediate;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation	PE1	1
+NX_P15941	Mucin-1	1255	122102	6.96	1	Cytoplasm;Cell membrane;Secreted;Apical cell membrane;Nucleus	Medullary cystic kidney disease 1	The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.;The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.	Proteolytic cleavage in the SEA domain occurs in the endoplasmic reticulum by an autoproteolytic mechanism and requires the full-length SEA domain as well as requiring a Ser, Thr or Cys residue at the P + 1 site. Cleavage at this site also occurs on isoform MUC1/X but not on isoform MUC1/Y. Ectodomain shedding is mediated by ADAM17.;The N-terminal sequence has been shown to begin at position 24 or 28.;Dual palmitoylation on cysteine residues in the CQC motif is required for recycling from endosomes back to the plasma membrane.;Highly glycosylated (N- and O-linked carbohydrates and sialic acid). O-glycosylated to a varying degree on serine and threonine residues within each tandem repeat, ranging from mono- to penta-glycosylation. The average density ranges from about 50% in human milk to over 90% in T47D breast cancer cells. Further sialylation occurs during recycling. Membrane-shed glycoproteins from kidney and breast cancer cells have preferentially sialyated core 1 structures, while secreted forms from the same tissues display mainly core 2 structures. The O-glycosylated content is overlapping in both these tissues with terminal fucose and galactose, 2- and 3-linked galactose, 3- and 3,6-linked GalNAc-ol and 4-linked GlcNAc predominating. Differentially O-glycosylated in breast carcinomas with 3,4-linked GlcNAc. N-glycosylation consists of high-mannose, acidic complex-type and hybrid glycans in the secreted form MUC1/SEC, and neutral complex-type in the transmembrane form, MUC1/TM.;Phosphorylated on tyrosines and serine residues in the C-terminal. Phosphorylation on tyrosines in the C-terminal increases the nuclear location of MUC1 and beta-catenin. Phosphorylation by PKC delta induces binding of MUC1 to beta-catenin/CTNNB1 and thus decreases the formation of the beta-catenin/E-cadherin complex. Src-mediated phosphorylation inhibits interaction with GSK3B. Src- and EGFR-mediated phosphorylation on Tyr-1229 increases binding to beta-catenin/CTNNB1. GSK3B-mediated phosphorylation on Ser-1227 decreases this interaction but restores the formation of the beta-cadherin/E-cadherin complex. On T-cell receptor activation, phosphorylated by LCK. PDGFR-mediated phosphorylation increases nuclear colocalization of MUC1CT and CTNNB1.;MUC1 is phosphorylated by EGFR (Phosphotyrosine:PTM-0255)	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Interleukin-4 and Interleukin-13 signaling	PE1	1
+NX_P15954	Cytochrome c oxidase subunit 7C, mitochondrial	63	7246	10.29	1	Mitochondrion inner membrane;Mitochondrion	NA	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase VIIc family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	5
+NX_P15976	Erythroid transcription factor	413	42751	9.03	0	Nucleoplasm;Nucleus	Thrombocytopenia with beta-thalassemia, X-linked;Anemia without thrombocytopenia, X-linked;X-linked dyserythropoietic anemia and thrombocytopenia	Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781).	Acetylated at 2 conserved lysine-rich motifs by CREBBP in vitro. Acetylation does not affect DNA-binding in vitro but is essential to induce erythroid differentiation and for binding chromatin in vivo (By similarity). Acetylated on Lys-233, Lys-245 Lys-246 by EP300.;Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation with SUMO1 has no effect on transcriptional activity (By similarity).;Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137 (By similarity).;GATA1 is phosphorylated by MAPK3	NA	Factors involved in megakaryocyte development and platelet production;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	X
+NX_P16035	Metalloproteinase inhibitor 2	220	24399	7.46	0	Cytoplasm;Secreted	NA	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.	The activity of TIMP2 is dependent on the presence of disulfide bonds.	Belongs to the protease inhibitor I35 (TIMP) family.	Activation of Matrix Metalloproteinases;Neutrophil degranulation	PE1	17
+NX_P16050	Arachidonate 15-lipoxygenase	662	74804	6.14	0	Cytosol;Cell membrane;Lipid droplet	NA	Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.	NA	Belongs to the lipoxygenase family.	Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.;Arachidonic acid metabolism;Linoleic acid metabolism;Metabolic pathways;Synthesis of 15-eicosatetraenoic acid derivatives;Synthesis of Leukotrienes (LT) and Eoxins (EX);Synthesis of 12-eicosatetraenoic acid derivatives;Interleukin-4 and Interleukin-13 signaling;Biosynthesis of DHA-derived SPMs;Biosynthesis of E-series 18(S)-resolvins;Biosynthesis of protectins;Biosynthesis of E-series 18(R)-resolvins;Biosynthesis of DPAn-6 SPMs;Biosynthesis of DPAn-3-derived protectins and resolvins	PE1	17
+NX_P16066	Atrial natriuretic peptide receptor 1	1061	118919	6.19	1	Membrane;Nucleoplasm;Nucleolus;Cell membrane	NA	Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.	Phosphorylation of the protein kinase-like domain is required for full activation by ANP.	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Vascular smooth muscle contraction;Physiological factors	PE1	1
+NX_P16070	CD44 antigen	742	81538	5.13	1	Golgi apparatus;Microvillus;Cell membrane	NA	Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640).	Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.;N-glycosylated.;O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.;Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.;CD44 is phosphorylated by TGFBR1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	ECM-receptor interaction;Hematopoietic cell lineage;Shigellosis;Degradation of the extracellular matrix;Interferon gamma signaling;Hyaluronan uptake and degradation;Integrin cell surface interactions;Cell surface interactions at the vascular wall;Neutrophil degranulation	PE1	11
+NX_P16083	Ribosyldihydronicotinamide dehydrogenase [quinone]	231	25919	5.87	0	Nucleoplasm;Cytoplasm;Cytosol	NA	The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.	NA	Belongs to the NAD(P)H dehydrogenase (quinone) family.	Phase I - Functionalization of compounds	PE1	6
+NX_P16104	Histone H2AX	143	15145	10.74	0	Nucleoplasm;Nucleus speckle;Nucleus;Chromosome	NA	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.	Acetylation at Lys-37 increases in S and G2 phases. This modification has been proposed to play a role in DNA double-strand break repair (By similarity).;Monoubiquitination of Lys-120 (H2AXK119ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression (By similarity). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.;Phosphorylated on Ser-140 (to form gamma-H2AX or H2AX139ph) in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks, and may also occur during meiotic recombination events and immunoglobulin class switching in lymphocytes. Phosphorylation can extend up to several thousand nucleosomes from the actual site of the DSB and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Widespread phosphorylation may also serve to amplify the damage signal or aid repair of persistent lesions. Phosphorylation of Ser-140 (H2AX139ph) in response to ionizing radiation is mediated by both ATM and PRKDC while defects in DNA replication induce Ser-140 phosphorylation (H2AX139ph) subsequent to activation of ATR and PRKDC. Dephosphorylation of Ser-140 by PP2A is required for DNA DSB repair. In meiosis, Ser-140 phosphorylation (H2AX139ph) may occur at synaptonemal complexes during leptotene as an ATM-dependent response to the formation of programmed DSBs by SPO11. Ser-140 phosphorylation (H2AX139ph) may subsequently occurs at unsynapsed regions of both autosomes and the XY bivalent during zygotene, downstream of ATR and BRCA1 activation. Ser-140 phosphorylation (H2AX139ph) may also be required for transcriptional repression of unsynapsed chromatin and meiotic sex chromosome inactivation (MSCI), whereby the X and Y chromosomes condense in pachytene to form the heterochromatic XY-body. During immunoglobulin class switch recombination in lymphocytes, Ser-140 phosphorylation (H2AX139ph) may occur at sites of DNA-recombination subsequent to activation of the activation-induced cytidine deaminase AICDA. Phosphorylation at Tyr-143 (H2AXY142ph) by BAZ1B/WSTF determines the relative recruitment of either DNA repair or pro-apoptotic factors. Phosphorylation at Tyr-143 (H2AXY142ph) favors the recruitment of APBB1/FE65 and pro-apoptosis factors such as MAPK8/JNK1, triggering apoptosis. In contrast, dephosphorylation of Tyr-143 by EYA proteins (EYA1, EYA2, EYA3 or EYA4) favors the recruitment of MDC1-containing DNA repair complexes to the tail of phosphorylated Ser-140 (H2AX139ph).	Belongs to the histone H2A family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;RMTs methylate histone arginines;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	11
+NX_P16109	P-selectin	830	90834	6.17	1	Cell membrane	Ischemic stroke	Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.	NA	Belongs to the selectin/LECAM family.	Cell adhesion molecules (CAMs);Malaria;Staphylococcus aureus infection;Cell surface interactions at the vascular wall;Platelet degranulation	PE1	1
+NX_P16112	Aggrecan core protein	2530	261329	4.06	0	Extracellular matrix	Spondyloepimetaphyseal dysplasia, aggrecan type;Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans;Spondyloepiphyseal dysplasia type Kimberley	This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.	Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.	Belongs to the aggrecan/versican proteoglycan family.	Degradation of the extracellular matrix;Keratan sulfate biosynthesis;Defective CHST6 causes MCDC1;Keratan sulfate degradation;Defective B4GALT1 causes B4GALT1-CDG (CDG-2d);ECM proteoglycans;Defective ST3GAL3 causes MCT12 and EIEE15	PE1	15
+NX_P16118	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1	471	54681	6.14	0	NA	NA	Synthesis and degradation of fructose 2,6-bisphosphate.	PFKFB1 is phosphorylated by PASK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	In the C-terminal section; belongs to the phosphoglycerate mutase family.	Fructose and mannose metabolism;PP2A-mediated dephosphorylation of key metabolic factors;PKA-mediated phosphorylation of key metabolic factors;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	X
+NX_P16144	Integrin beta-4	1822	202167	5.74	1	Cell junction;Hemidesmosome;Cell membrane	Epidermolysis bullosa simplex, Weber-Cockayne type;Generalized atrophic benign epidermolysis bullosa;Epidermolysis bullosa letalis, with pyloric atresia	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).	Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secondary association with tertaspanins.	Belongs to the integrin beta chain family.	Focal adhesion;ECM-receptor interaction;Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Syndecan interactions;Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly;Laminin interactions	PE1	17
+NX_P16150	Leukosialin	400	40322	5.01	1	Cell membrane;Membrane;Uropodium;PML body;Microvillus;Nucleus	NA	CD43 cytoplasmic tail: Protects cells from apoptotic signals, promoting cell survival.;Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity).	CD43 cytoplasmic tail: Sumoylated.;Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.;Has a high content of sialic acid and O-linked carbohydrate structures.;Cleavage by CTSG releases its extracellular domain and triggers its intramembrane proteolysis by gamma-secretase releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus.;Phosphorylation at Ser-355 is regulated by chemokines, requires its association with ERM proteins (EZR, RDX and MSN) and is essential for its function in the regulation of T-cell trafficking to lymph nodes.	NA	Cell adhesion molecules (CAMs);Cell surface interactions at the vascular wall;Basigin interactions	PE1	16
+NX_P16152	Carbonyl reductase [NADPH] 1	277	30375	8.55	0	Nucleoplasm;Cytosol;Cytoplasm	NA	NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Arachidonic acid metabolism;Metabolism of xenobiotics by cytochrome P450;Metabolic pathways;Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	PE1	21
+NX_P16157	Ankyrin-1	1881	206265	5.65	0	Membrane;Sarcoplasmic reticulum;M line;Cytoskeleton	Spherocytosis 1	Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.;Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.	Palmitoylated.;Regulated by phosphorylation.;Hydroxylated by HIF1AN at several asparagine and 1 aspartate residue within ANK repeat region. Hydroxylation seems to increase the conformational stability of this region and may also modulate protein-protein interactions mediated by the ANK repeat region.	NA	Interaction between L1 and Ankyrins;CHL1 interactions;NrCAM interactions;Neurofascin interactions;COPI-mediated anterograde transport	PE1	8
+NX_P16219	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	412	44297	8.13	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	Acyl-CoA dehydrogenase short-chain deficiency	Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:21237683, PubMed:11134486).	NA	Belongs to the acyl-CoA dehydrogenase family.	Lipid metabolism; mitochondrial fatty acid beta-oxidation.;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Butanoate metabolism;Metabolic pathways;Beta oxidation of hexanoyl-CoA to butanoyl-CoA;Beta oxidation of butanoyl-CoA to acetyl-CoA	PE1	12
+NX_P16220	Cyclic AMP-responsive element-binding protein 1	341	36688	5.46	0	Nucleoplasm;Nucleus	Angiomatoid fibrous histiocytoma	Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.	Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.;Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Phosphorylated by TSSK4 on Ser-133 (PubMed:15964553).;CREB1 is phosphorylated by SGK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the bZIP family.	Osteoclast differentiation;Antigen processing and presentation;Cholinergic synapse;Dopaminergic synapse;Melanogenesis;Vasopressin-regulated water reabsorption;Huntington's disease;Tuberculosis;HTLV-I infection;Prostate cancer;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;NOTCH2 intracellular domain regulates transcription;AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;Gastrin-CREB signalling pathway via PKC and MAPK;NCAM signaling for neurite out-growth;CREB phosphorylation;PKA-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of Adenylate Cyclase;CaMK IV-mediated phosphorylation of CREB;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;MECP2 regulates transcription of neuronal ligands;MECP2 regulates transcription factors;Estrogen-dependent nuclear events downstream of ESR-membrane signaling;Transcriptional regulation of granulopoiesis	PE1	2
+NX_P16233	Pancreatic triacylglycerol lipase	465	51157	6.27	0	Secreted	Pancreatic lipase deficiency	NA	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Glycerolipid metabolism;Metabolic pathways;Pancreatic secretion;Fat digestion and absorption;Vitamin digestion and absorption;Retinoid metabolism and transport;Digestion of dietary lipid	PE1	10
+NX_P16234	Platelet-derived growth factor receptor alpha	1089	122670	5.05	1	Golgi apparatus;Cell membrane;Cell junction;Cilium;Nucleoplasm	Gastrointestinal stromal tumor	Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.	Ubiquitinated, leading to its internalization and degradation.;Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. One subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-731 and Tyr-742 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-754 is important for interaction with PTPN11. Phosphorylation at Tyr-762 is important for interaction with CRK. Phosphorylation at Tyr-572 and Tyr-574 is important for interaction with SRC and SRC family members. Phosphorylation at Tyr-988 and Tyr-1018 is important for interaction with PLCG1.;N-glycosylated.	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	MAPK signaling pathway;Calcium signaling pathway;Cytokine-cytokine receptor interaction;Endocytosis;Focal adhesion;Gap junction;Regulation of actin cytoskeleton;HTLV-I infection;Pathways in cancer;Glioma;Prostate cancer;Melanoma;RAF/MAP kinase cascade;Signaling by PDGF;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Downstream signal transduction;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	4
+NX_P16260	Graves disease carrier protein	332	36224	9.87	6	Mitochondrion inner membrane;Mitochondrion	NA	Required for the accumulation of coenzyme A in the mitochondrial matrix.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Coenzyme A biosynthesis	PE1	10
+NX_P16278	Beta-galactosidase	677	76075	6.1	0	Golgi apparatus;Cytoplasmic vesicle;Perinuclear region;Lysosome	Mucopolysaccharidosis 4B;GM1-gangliosidosis 1;GM1-gangliosidosis 3;GM1-gangliosidosis 2	Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.;Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.	NA	Belongs to the glycosyl hydrolase 35 family.	Galactose metabolism;Other glycan degradation;Glycosaminoglycan degradation;Sphingolipid metabolism;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Lysosome;Sialic acid metabolism;Glycosphingolipid metabolism;Defective NEU1 causes sialidosis;Keratan sulfate degradation;HS-GAG degradation;MPS IV - Morquio syndrome B;Neutrophil degranulation	PE1	3
+NX_P16284	Platelet endothelial cell adhesion molecule	738	82522	6.55	1	Cell junction;Membrane raft;Cell membrane	NA	Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity).;Does not protect against apoptosis.	Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts.;Phosphorylated on Ser and Tyr residues after cellular activation by src kinases (PubMed:21464369, PubMed:9298995, PubMed:19342684, PubMed:18710921). Upon activation, phosphorylated on Ser-729 which probably initiates the dissociation of the membrane-interaction segment (residues 709-729) from the cell membrane allowing the sequential phosphorylation of Tyr-713 and Tyr-690 (PubMed:21464369). Constitutively phosphorylated on Ser-734 in resting platelets (PubMed:21464369). Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation (PubMed:18710921).;PECAM1 is phosphorylated by MATK (Phosphotyrosine:PTM-0255)	NA	Cell adhesion molecules (CAMs);Leukocyte transendothelial migration;Malaria;Integrin cell surface interactions;Cell surface interactions at the vascular wall;Platelet degranulation;PECAM1 interactions;Platelet sensitization by LDL;Neutrophil degranulation	PE1	17
+NX_P16298	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	524	59024	5.6	0	Cytoplasm;Mitochondrion	NA	Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).	NA	Belongs to the PPP phosphatase family. PP-2B subfamily.	MAPK signaling pathway;Calcium signaling pathway;Oocyte meiosis;Apoptosis;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Osteoclast differentiation;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Long-term potentiation;Glutamatergic synapse;Dopaminergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Tuberculosis;HTLV-I infection;FCERI mediated Ca+2 mobilization;DARPP-32 events;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation;Calcineurin activates NFAT;ROBO receptors bind AKAP5	PE1	10
+NX_P16333	Cytoplasmic protein NCK1	377	42864	6.06	0	Cytoplasm;Cell membrane;Endoplasmic reticulum;Cytosol;Nucleus	NA	Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.	Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB.;NCK1 is phosphorylated by FYN (Phosphotyrosine:PTM-0255);NCK1 is phosphorylated by PAK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	ErbB signaling pathway;Axon guidance;T cell receptor signaling pathway;Pathogenic Escherichia coli infection;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;Generation of second messenger molecules;VEGFA-VEGFR2 Pathway;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Nephrin family interactions;DCC mediated attractive signaling;Activation of RAC1;Downstream signal transduction	PE1	3
+NX_P16383	GC-rich sequence DNA-binding factor 2	781	89385	5.71	0	Nucleoplasm;Nucleolus	NA	Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons.	NA	Belongs to the GCF family.	mRNA Splicing - Major Pathway	PE1	2
+NX_P16389	Potassium voltage-gated channel subfamily A member 2	499	56717	4.78	6	Endoplasmic reticulum membrane;Presynaptic cell membrane;Synaptosome;Cell membrane;Lamellipodium membrane;Membrane;Synapse;Paranodal septate junction;Axon;Dendrite	Epileptic encephalopathy, early infantile, 32	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559, PubMed:11211111, PubMed:23769686). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559, PubMed:20220134). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:23769686). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity).	Phosphorylated on tyrosine residues; phosphorylation increases in response to ischemia (By similarity). Phosphorylated on tyrosine residues by activated PTK2B/PYK2 (By similarity). Phosphorylation on tyrosine residues suppresses ion channel activity (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation; this abolishes interaction with CTTN. This is probably due to endocytosis of the phosphorylated channel subunits (By similarity). Phosphorylated on serine residues in response to increased cAMP levels; phosphorylation is apparently not catalyzed by PKA (By similarity).;N-glycosylated, with complex, sialylated N-glycans.	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.	Voltage gated Potassium channels	PE1	1
+NX_P16401	Histone H1.5	226	22580	10.91	0	Nucleoplasm;Nucleus;Chromosome	NA	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).	Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.;H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter (By similarity). Phosphorylated at Thr-11 by GSK3B during mitosis in prometaphase and dephosphorylated in telophase.	Belongs to the histone H1/H5 family.	Formation of Senescence-Associated Heterochromatin Foci (SAHF);Apoptosis induced DNA fragmentation	PE1	6
+NX_P16402	Histone H1.3	221	22350	11.02	0	Nucleus;Chromosome	NA	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).	H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.;Citrullination at Arg-55 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.	Belongs to the histone H1/H5 family.	Formation of Senescence-Associated Heterochromatin Foci (SAHF);Apoptosis induced DNA fragmentation	PE1	6
+NX_P16403	Histone H1.2	213	21365	10.94	0	Nucleoplasm;Nucleolus;Nucleus;Chromosome	NA	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).	H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.;Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.;ADP-ribosylated on Ser-188 in response to DNA damage.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.	Belongs to the histone H1/H5 family.	Formation of Senescence-Associated Heterochromatin Foci (SAHF);Apoptosis induced DNA fragmentation	PE1	6
+NX_P16410	Cytotoxic T-lymphocyte protein 4	223	24656	6.7	1	Cell membrane	Celiac disease 3;Autoimmune lymphoproliferative syndrome 5;Systemic lupus erythematosus;Diabetes mellitus, insulin-dependent, 12	Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.;N-glycosylation is important for dimerization.	NA	Cell adhesion molecules (CAMs);T cell receptor signaling pathway;Autoimmune thyroid disease;Rheumatoid arthritis;CTLA4 inhibitory signaling;RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	PE1	2
+NX_P16415	Zinc finger protein 823	610	70270	9.04	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P16422	Epithelial cell adhesion molecule	314	34932	7.42	1	Tight junction;Lateral cell membrane;Cell membrane	Diarrhea 5, with tufting enteropathy, congenital;Hereditary non-polyposis colorectal cancer 8	May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.	Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.	Belongs to the EPCAM family.	Cell surface interactions at the vascular wall	PE1	2
+NX_P16435	NADPH--cytochrome P450 reductase	677	76690	5.38	1	Endoplasmic reticulum membrane;Endoplasmic reticulum;Nucleoplasm;Cytoplasmic vesicle;Cytosol	Antley-Bixler syndrome, with genital anomalies and disordered steroidogenesis;Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency	This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.	NA	In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.;Belongs to the NADPH--cytochrome P450 reductase family.;In the N-terminal section; belongs to the flavodoxin family.	Cytochrome P450 - arranged by substrate type	PE1	7
+NX_P16442	Histo-blood group ABO system transferase	354	40934	9.14	1	Golgi stack membrane;Secreted	NA	This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.	The soluble form derives from the membrane form by proteolytic processing.	Belongs to the glycosyltransferase 6 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;ABO blood group biosynthesis	PE1	9
+NX_P16444	Dipeptidase 1	411	45674	5.75	0	Nucleoplasm;Apical cell membrane;Cell junction;Microvillus membrane	NA	Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.	NA	Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.	Aflatoxin activation and detoxification;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	16
+NX_P16452	Erythrocyte membrane protein band 4.2	691	77009	8.39	0	Nucleoplasm;Cytosol;Cytoskeleton;Cell membrane	Spherocytosis 5	Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.	Both cAMP-dependent kinase (CAPK) and another kinase present in the red-blood cells seem to be able to phosphorylate EPB42.	Belongs to the transglutaminase superfamily. Transglutaminase family.	NA	PE1	15
+NX_P16455	Methylated-DNA--protein-cysteine methyltransferase	207	21646	8.28	0	Nucleoplasm;Nucleus	NA	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.	NA	Belongs to the MGMT family.	MGMT-mediated DNA damage reversal	PE1	10
+NX_P16471	Prolactin receptor	622	69506	5.23	1	Membrane;Secreted	Hyperprolactinemia;Multiple fibroadenomas of the breast	Is unable to transduce prolactin signaling.;Is unable to transduce prolactin signaling.;This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT.	NA	Belongs to the type I cytokine receptor family. Type 1 subfamily.	Cytokine-cytokine receptor interaction;Neuroactive ligand-receptor interaction;Jak-STAT signaling pathway;Prolactin receptor signaling;Growth hormone receptor signaling	PE1	5
+NX_P16473	Thyrotropin receptor	764	86830	6.56	7	Basolateral cell membrane;Cell membrane	Hyperthyroidism, non-autoimmune;Familial gestational hyperthyroidism;Hypothyroidism, congenital, non-goitrous, 1	Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity).	Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation.;Glycosylated.	Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	Neuroactive ligand-receptor interaction;Autoimmune thyroid disease;G alpha (s) signalling events;Hormone ligand-binding receptors	PE1	14
+NX_P16499	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	860	99547	5.48	0	Cell membrane	Retinitis pigmentosa 43	This protein participates in processes of transmission and amplification of the visual signal.	NA	Belongs to the cyclic nucleotide phosphodiesterase family.	Purine metabolism;Phototransduction;Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Ca2+ pathway	PE1	5
+NX_P16519	Neuroendocrine convertase 2	638	70565	6.04	0	Cytoplasmic vesicle;Secreted;Secretory vesicle	NA	Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.	NA	Belongs to the peptidase S8 family. Furin subfamily.	Insulin processing	PE1	20
+NX_P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	340	37221	5.39	0	NA	Night blindness, congenital stationary, 1H	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the WD repeat G protein beta family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Taste transduction;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	12
+NX_P16562	Cysteine-rich secretory protein 2	243	27259	6.09	0	Secreted	NA	May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.	NA	Belongs to the CRISP family.	NA	PE1	6
+NX_P16581	E-selectin	610	66655	5.2	1	Cell membrane	NA	Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.	NA	Belongs to the selectin/LECAM family.	Cell adhesion molecules (CAMs);African trypanosomiasis;Malaria;Cell surface interactions at the vascular wall	PE1	1
+NX_P16591	Tyrosine-protein kinase Fer	822	94638	6.72	0	Cytoplasm;Cell cortex;Cell membrane;Cell junction;Cell projection;Membrane;Cytosol;Nucleus;Cytoskeleton	NA	Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.	Polyubiquitinated; this leads to proteasomal degradation.;Autophosphorylated.;Autophosphorylated (Phosphotyrosine:PTM-0255);FER is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	Adherens junction;Signaling by SCF-KIT	PE1	5
+NX_P16615	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	1042	114757	5.23	10	Endoplasmic reticulum membrane;Sarcoplasmic reticulum membrane	Darier disease;Acrokeratosis verruciformis	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen.;Is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity).	Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity.	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.	Calcium signaling pathway;Cardiac muscle contraction;Pancreatic secretion;Alzheimer's disease;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Ion transport by P-type ATPases;Pre-NOTCH Processing in Golgi;Reduction of cytosolic Ca++ levels;Ion homeostasis	PE1	12
+NX_P16619	C-C motif chemokine 3-like 1	93	10161	4.77	0	Secreted	NA	Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.	The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Salmonella infection;Chagas disease (American trypanosomiasis);Rheumatoid arthritis;Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Salmonella infection;Chagas disease (American trypanosomiasis);Rheumatoid arthritis;Interleukin-10 signaling	PE1	17
+NX_P16662	UDP-glucuronosyltransferase 2B7	529	60721	8.54	1	Microsome membrane;Endoplasmic reticulum membrane	NA	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.;Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	4
+NX_P16671	Platelet glycoprotein 4	472	53053	8.19	2	Golgi apparatus;Apical cell membrane;Membrane raft;Cell membrane	Coronary heart disease 7;Platelet glycoprotein IV deficiency	(Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.;Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).	Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome (PubMed:21610069, PubMed:18353783). Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids (PubMed:18353783).;N-glycosylated and O-glycosylated with a ratio of 2:1.	Belongs to the CD36 family.	PPAR signaling pathway;Phagosome;ECM-receptor interaction;Hematopoietic cell lineage;Adipocytokine signaling pathway;Fat digestion and absorption;Malaria;ER-Phagosome pathway;PPARA activates gene expression;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);Platelet degranulation;Transcriptional regulation of white adipocyte differentiation;Cross-presentation of particulate exogenous antigens (phagosomes);Toll Like Receptor TLR6:TLR2 Cascade;Scavenging by Class B Receptors;Regulation of TLR by endogenous ligand;Neutrophil degranulation;Interleukin-4 and Interleukin-13 signaling;Intracellular metabolism of fatty acids regulates insulin secretion	PE1	7
+NX_P16860	Natriuretic peptides B	134	14726	10.34	0	Secreted	NA	Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.	The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro).	Belongs to the natriuretic peptide family.	NA	PE1	1
+NX_P16870	Carboxypeptidase E	476	53151	5.03	0	Secreted;Nucleoplasm;Secretory vesicle membrane;Centrosome;Cytoplasmic vesicle;Secretory vesicle;Nucleus	NA	Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.	NA	Belongs to the peptidase M14 family.	Type I diabetes mellitus;Insulin processing	PE1	4
+NX_P16871	Interleukin-7 receptor subunit alpha	459	51579	5.27	1	Centriolar satellite;Secreted;Cell membrane	Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive;Multiple sclerosis 3	Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).	N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.	Belongs to the type I cytokine receptor family. Type 4 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Primary immunodeficiency;Interleukin-7 signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	5
+NX_P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	1265	147870	6.21	0	Cytoplasmic vesicle	Autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated;Familial cold autoinflammatory syndrome 3	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.	Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.;PLCG2 is phosphorylated by MERTK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Inositol phosphate metabolism;Metabolic pathways;ErbB signaling pathway;Calcium signaling pathway;Phosphatidylinositol signaling system;VEGF signaling pathway;Osteoclast differentiation;Natural killer cell mediated cytotoxicity;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Glioma;Non-small cell lung cancer;CLEC7A (Dectin-1) signaling;GPVI-mediated activation cascade;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Toll Like Receptor 4 (TLR4) Cascade;Dectin-2 family;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Synthesis of IP3 and IP4 in the cytosol;Erythropoietin activates Phospholipase C gamma (PLCG)	PE1	16
+NX_P16930	Fumarylacetoacetase	419	46374	6.46	0	Cytosol	Tyrosinemia 1	NA	NA	Belongs to the FAH family.	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.;Tyrosine metabolism;Metabolic pathways;Tyrosine catabolism	PE1	15
+NX_P16949	Stathmin	149	17303	5.76	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).	Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.;STMN1 is phosphorylated by MAPK3	Belongs to the stathmin family.	MAPK signaling pathway;Nuclear signaling by ERBB4	PE1	1
+NX_P16989	Y-box-binding protein 3	372	40090	9.77	0	Cytoplasm;Cytosol;Nucleus	NA	Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity).	NA	NA	Tight junction	PE1	12
+NX_P17010	Zinc finger X-chromosomal protein	805	90522	5.71	0	Nucleus	NA	Probable transcriptional activator.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.	NA	PE1	X
+NX_P17014	Zinc finger protein 12	697	81202	8.12	0	Nucleoplasm;Centrosome;Nucleus	NA	Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_P17017	Zinc finger protein 14	642	75353	9.36	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_P17019	Zinc finger protein 708	499	57357	9.5	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_P17020	Zinc finger protein 16	682	76472	8.31	0	Nucleoplasm;Nucleolus;Nucleus	NA	Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_P17021	Zinc finger protein 17	662	77204	8.81	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_P17022	Zinc finger protein 18	549	62288	5.65	0	Golgi apparatus;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	17
+NX_P17023	Zinc finger protein 19	458	52449	7.98	0	Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_P17024	Zinc finger protein 20	532	61567	8.94	0	Nucleoplasm;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_P17025	Zinc finger protein 182	639	73646	8.97	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	X
+NX_P17026	Zinc finger protein 22	224	25915	10.06	0	Nucleoplasm;Nucleus	NA	Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	10
+NX_P17027	Zinc finger protein 23	643	73059	8.49	0	Cytosol;Nucleus	NA	May be involved in transcriptional regulation. May have a role in embryonic development.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_P17028	Zinc finger protein 24	368	42155	5.82	0	Nucleoplasm;Nucleus	NA	Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.	Sumoylated.	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	18
+NX_P17029	Zinc finger protein with KRAB and SCAN domains 1	563	63630	6.6	0	Nucleoplasm;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_P17030	Zinc finger protein 25	456	53545	9.22	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	10
+NX_P17031	Zinc finger protein 26	533	61282	9.12	0	Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	12
+NX_P17032	Zinc finger protein 37A	561	65418	8.53	0	Cytoplasmic vesicle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	10
+NX_P17035	Zinc finger protein 28	718	83658	9.25	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_P17036	Zinc finger protein 3	446	50916	7.31	0	Nucleoplasm;Nucleus	NA	Involved in cell differentiation and/or proliferation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_P17038	Zinc finger protein 43	809	94124	9.35	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_P17039	Zinc finger protein 30	623	71417	9.27	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_P17040	Zinc finger and SCAN domain-containing protein 20	1043	117541	6.01	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_P17041	Zinc finger protein 32	273	31029	9.52	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	10
+NX_P17050	Alpha-N-acetylgalactosaminidase	411	46565	4.98	0	Lysosome	Kanzaki disease;Schindler disease	Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.	NA	Belongs to the glycosyl hydrolase 27 family.	Glycosphingolipid biosynthesis - globo series;Lysosome	PE1	22
+NX_P17066	Heat shock 70 kDa protein 6	643	71028	5.81	0	NA	NA	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).	NA	Belongs to the heat shock protein 70 family.	Spliceosome;MAPK signaling pathway;Protein processing in endoplasmic reticulum;Endocytosis;Antigen processing and presentation;Legionellosis;Toxoplasmosis;Measles;Influenza A;Regulation of HSF1-mediated heat shock response;Neutrophil degranulation	PE1	1
+NX_P17081	Rho-related GTP-binding protein RhoQ	205	22659	5.94	0	Cytoplasmic vesicle;Cytoplasm;Cytosol;Cell membrane	NA	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.	May be post-translationally modified by both palmitoylation and polyisoprenylation.	Belongs to the small GTPase superfamily. Rho family.	Insulin signaling pathway;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Rho GTPase cycle;RHO GTPases regulate CFTR trafficking	PE1	2
+NX_P17096	High mobility group protein HMG-I/HMG-Y	107	11676	10.31	0	Nucleoplasm;Nucleolus;Nucleus;Chromosome	NA	HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.	Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.;Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.;HMG-Y is not methylated.	Belongs to the HMGA family.	Vpr-mediated nuclear import of PICs;Formation of Senescence-Associated Heterochromatin Foci (SAHF);Integration of provirus;2-LTR circle formation;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection	PE1	6
+NX_P17097	Zinc finger protein 7	686	77887	8.67	0	Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_P17098	Zinc finger protein 8	575	64970	7.04	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P17152	Transmembrane protein 11, mitochondrial	192	21541	6.98	2	Mitochondrion inner membrane;Mitochondrion;Cell membrane	NA	Plays a role in mitochondrial morphogenesis.	NA	Belongs to the TMEM11 family.	Cristae formation	PE1	17
+NX_P17174	Aspartate aminotransferase, cytoplasmic	413	46248	6.53	0	Nucleoplasm;Cytoplasm;Cytosol	NA	Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.	NA	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	Alanine, aspartate and glutamate metabolism;Cysteine and methionine metabolism;Arginine and proline metabolism;Tyrosine metabolism;Phenylalanine metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis;Metabolic pathways;Gluconeogenesis;Methionine salvage pathway;Aspartate and asparagine metabolism	PE1	10
+NX_P17181	Interferon alpha/beta receptor 1	557	63525	5.58	1	Lysosome;Late endosome;Cell membrane	NA	Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.;Ubiquitinated, leading to its internalization and degradation (PubMed:14532120, PubMed:15337770). Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation (PubMed:18056411). The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex (PubMed:24075985).;Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination (PubMed:14532120, PubMed:15337770, PubMed:24075985). Phosphorylated on tyrosine residues by TYK2 tyrosine kinase (PubMed:7526154). Phosphorylated on tyrosine residues in response to interferon (PubMed:10049744).	Belongs to the type II cytokine receptor family.	Cytokine-cytokine receptor interaction;Osteoclast differentiation;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Interferon alpha/beta signaling;Regulation of IFNA signaling	PE1	21
+NX_P17213	Bactericidal permeability-increasing protein	487	53900	9.41	0	Cytoplasmic granule membrane;Secreted	NA	The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.	NA	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Toll Like Receptor 4 (TLR4) Cascade;Neutrophil degranulation;Antimicrobial peptides	PE1	20
+NX_P17252	Protein kinase C alpha type	672	76750	6.61	0	Cytoplasm;Cell membrane;Mitochondrion membrane;Cytosol;Nucleus	NA	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	MAPK signaling pathway;ErbB signaling pathway;Calcium signaling pathway;Phosphatidylinositol signaling system;Vascular smooth muscle contraction;Wnt signaling pathway;VEGF signaling pathway;Focal adhesion;Tight junction;Gap junction;Natural killer cell mediated cytotoxicity;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Long-term depression;GnRH signaling pathway;Melanogenesis;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Vibrio cholerae infection;Pathogenic Escherichia coli infection;African trypanosomiasis;Amoebiasis;Influenza A;Pathways in cancer;Glioma;Non-small cell lung cancer;SHC1 events in ERBB2 signaling;EGFR Transactivation by Gastrin;Syndecan interactions;Inactivation, recovery and regulation of the phototransduction cascade;Signaling by SCF-KIT;Regulation of KIT signaling;Ca2+ pathway;G alpha (z) signalling events;WNT5A-dependent internalization of FZD4;Depolymerisation of the Nuclear Lamina;VEGFR2 mediated cell proliferation;HuR (ELAVL1) binds and stabilizes mRNA;RHO GTPases Activate NADPH Oxidases;Acetylcholine regulates insulin secretion;Calmodulin induced events;Disinhibition of SNARE formation;Trafficking of GluR2-containing AMPA receptors;Response to elevated platelet cytosolic Ca2+;RET signaling;ROBO receptors bind AKAP5	PE1	17
+NX_P17275	Transcription factor jun-B	347	35879	9.27	0	Nucleoplasm;Nucleus	NA	Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.	Ubiquitinated by ITCH, leading to its degradation.	Belongs to the bZIP family. Jun subfamily.	Osteoclast differentiation;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Interleukin-4 and Interleukin-13 signaling	PE1	19
+NX_P17301	Integrin alpha-2	1181	129295	5.16	1	Membrane;Nucleoplasm;Cytosol	NA	(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A.;Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.;(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.	NA	Belongs to the integrin alpha chain family.	Phagosome;Focal adhesion;ECM-receptor interaction;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Pathways in cancer;Small cell lung cancer;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Syndecan interactions;Integrin cell surface interactions;ECM proteoglycans;CHL1 interactions;Platelet Adhesion to exposed collagen;Laminin interactions;MET activates PTK2 signaling	PE1	5
+NX_P17302	Gap junction alpha-1 protein	382	43008	8.96	4	Cell membrane;Cell junction;Gap junction;Endoplasmic reticulum;Nucleoplasm;Cytoplasmic vesicle	Erythrokeratodermia variabilis et progressiva 3;Oculodentodigital dysplasia;Hallermann-Streiff syndrome;Palmoplantar keratoderma and congenital alopecia 1;Syndactyly 3;Atrioventricular septal defect 3;Craniometaphyseal dysplasia, autosomal recessive;Oculodentodigital dysplasia, autosomal recessive;Hypoplastic left heart syndrome 1	Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).	S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication.;Acetylated in the developing cortex; leading to delocalization from the cell membrane.;Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2.;Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity (By similarity). Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (By similarity).	Belongs to the connexin family. Alpha-type (group II) subfamily.	Gap junction;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Gap junction degradation;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Formation of annular gap junctions;Oligomerization of connexins into connexons;Transport of connexins along the secretory pathway;Regulation of gap junction activity	PE1	6
+NX_P17342	Atrial natriuretic peptide receptor 3	541	59808	5.93	1	Membrane;Cytosol	NA	Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.	NA	Belongs to the ANF receptor family.	NA	PE1	5
+NX_P17405	Sphingomyelin phosphodiesterase	631	69936	6.9	0	Secreted;Lysosome	Niemann-Pick disease B;Niemann-Pick disease A	Converts sphingomyelin to ceramide (PubMed:1840600, PubMed:18815062, PubMed:27659707, PubMed:25920558). Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.;Lacks residues that bind the cofactor Zn(2+) and has no enzyme activity.;Lacks residues that bind the cofactor Zn(2+) and has no enzyme activity.	NA	Belongs to the acid sphingomyelinase family.	Sphingolipid metabolism;Metabolic pathways;Lysosome;Glycosphingolipid metabolism	PE1	11
+NX_P17480	Nucleolar transcription factor 1	764	89406	5.63	0	Nucleolus	Neurodegeneration, childhood-onset, with brain atrophy	Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.	Phosphorylated and activated by PIK3CA.	NA	NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;RNA Polymerase I Promoter Opening	PE1	17
+NX_P17481	Homeobox protein Hox-B8	243	27574	8.48	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	NA	PE1	17
+NX_P17482	Homeobox protein Hox-B9	250	28059	9.01	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	17
+NX_P17483	Homeobox protein Hox-B4	251	27604	9.82	0	Nucleoplasm;Centrosome;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family. Deformed subfamily.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	17
+NX_P17509	Homeobox protein Hox-B6	224	25432	8.45	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	NA	PE1	17
+NX_P17516	Aldo-keto reductase family 1 member C4	323	37067	6.46	0	Cytoplasm	46,XY sex reversal 8	Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.	The N-terminus is blocked.	Belongs to the aldo/keto reductase family.	Primary bile acid biosynthesis;Steroid hormone biosynthesis;Metabolism of xenobiotics by cytochrome P450;Metabolic pathways;Retinoid metabolism and transport;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol	PE1	10
+NX_P17535	Transcription factor jun-D	347	35174	6.86	0	Nucleoplasm;Nucleus	NA	Transcription factor binding AP-1 sites.	NA	Belongs to the bZIP family. Jun subfamily.	MAPK signaling pathway;Osteoclast differentiation;Estrogen-dependent gene expression	PE1	19
+NX_P17538	Chymotrypsinogen B	263	27713	6.79	0	Extracellular space	NA	NA	NA	Belongs to the peptidase S1 family.	Cobalamin (Cbl, vitamin B12) transport and metabolism;Activation of Matrix Metalloproteinases	PE1	16
+NX_P17540	Creatine kinase S-type, mitochondrial	419	47504	8.46	0	Mitochondrion inner membrane	NA	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. Creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.	NA	Belongs to the ATP:guanido phosphotransferase family.	Arginine and proline metabolism;Metabolic pathways;Creatine metabolism	PE1	5
+NX_P17542	T-cell acute lymphocytic leukemia protein 1	331	34271	7.81	0	Nucleoplasm;Nucleus	NA	Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).	Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).;Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).	NA	RUNX1 regulates transcription of genes involved in differentiation of HSCs;Transcriptional regulation of granulopoiesis	PE1	1
+NX_P17544	Cyclic AMP-dependent transcription factor ATF-7	494	52967	8.88	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.;Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.;Acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.	Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12. RANBP2 appears to be the specific E3 ligase.;On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity.	Belongs to the bZIP family.	NA	PE1	12
+NX_P17568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	137	16402	9.1	0	Cytoplasm;Mitochondrion intermembrane space;Mitochondrion inner membrane	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFB7 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	19
+NX_P17600	Synapsin-1	705	74111	9.84	0	Golgi apparatus;Synapse	Epilepsy X-linked, with variable learning disabilities and behavior disorders	Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.	Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.;Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.;SYN1 is phosphorylated by CAMK1G;SYN1 is phosphorylated by CAMK1G (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the synapsin family.	Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle	PE1	X
+NX_P17612	cAMP-dependent protein kinase catalytic subunit alpha	351	40590	8.84	0	Cytoplasm;Mitochondrion;Cell membrane;Membrane;Flagellum;Nucleus;Acrosome	Primary pigmented nodular adrenocortical disease 4	Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA.;Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490).	Autophosphorylated. Phosphorylation is enhanced by vitamin K(2). Phosphorylated on threonine and serine residues. Phosphorylation on Thr-198 is required for full activity.;Phosphorylated at Tyr-331 by activated receptor tyrosine kinases EGFR and PDGFR; this increases catalytic efficiency.;Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.	MAPK signaling pathway;Calcium signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Apoptosis;Vascular smooth muscle contraction;Wnt signaling pathway;Hedgehog signaling pathway;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Olfactory transduction;Taste transduction;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;MAPK6/MAPK4 signaling;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Factors involved in megakaryocyte development and platelet production;VEGFA-VEGFR2 Pathway;Triglyceride catabolism;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Recruitment of NuMA to mitotic centrosomes;Interleukin-3, Interleukin-5 and GM-CSF signaling;CD209 (DC-SIGN) signaling;Regulation of insulin secretion;PKA-mediated phosphorylation of CREB;PKA-mediated phosphorylation of key metabolic factors;Rap1 signalling;CREB1 phosphorylation through the activation of Adenylate Cyclase;AURKA Activation by TPX2;Ion homeostasis;RET signaling;HDL assembly;ROBO receptors bind AKAP5;Regulation of MECP2 expression and activity;Loss of phosphorylation of MECP2 at T308;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	19
+NX_P17643	5,6-dihydroxyindole-2-carboxylic acid oxidase	537	60724	5.62	1	Cytoplasmic vesicle;Melanosome;Melanosome membrane	Albinism, oculocutaneous, 3	Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).	Glycosylated.	Belongs to the tyrosinase family.	Pigment biosynthesis; melanin biosynthesis.;Tyrosine metabolism;Metabolic pathways;Melanogenesis;Melanin biosynthesis	PE1	9
+NX_P17655	Calpain-2 catalytic subunit	700	79995	4.87	0	Cytoplasm;Cytosol;Cell membrane	NA	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).	NA	Belongs to the peptidase C2 family.	Protein processing in endoplasmic reticulum;Apoptosis;Focal adhesion;Alzheimer's disease;Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	PE1	1
+NX_P17658	Potassium voltage-gated channel subfamily A member 6	529	58729	4.9	6	Cell membrane	NA	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).	NA	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.	Voltage gated Potassium channels	PE1	12
+NX_P17661	Desmin	470	53536	5.21	0	Cytoplasm;Z line;Sarcolemma;Nucleus;Cytoskeleton	Cardiomyopathy, dilated 1I;Myopathy, myofibrillar, 1;Neurogenic scapuloperoneal syndrome Kaeser type	Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity).	ADP-ribosylation prevents ability to form intermediate filaments.;Phosphorylation at Ser-7, Ser-28 and Ser-32 by CDK1, phosphorylation at Ser-60 by AURKB and phosphorylation at Thr-76 by ROCK1 contribute to efficient separation of desmin intermediate filaments during mitosis.;DES is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254)	Belongs to the intermediate filament family.	Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Striated Muscle Contraction	PE1	2
+NX_P17676	CCAAT/enhancer-binding protein beta	345	36106	8.55	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity).;Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity).;Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.	Sumoylated by polymeric chains of SUMO2 or SUMO3 (PubMed:12810706). Sumoylation at Lys-174 is required for inhibition of T-cells proliferation. In adipocytes, sumoylation at Lys-174 by PIAS1 leads to ubiquitination and subsequent proteasomal degradation. Desumoylated by SENP2, which abolishes ubiquitination and stabilizes protein levels (By similarity).;Acetylated. Acetylation at Lys-43 is an important and dynamic regulatory event that contributes to its ability to transactivate target genes, including those associated with adipogenesis and adipocyte function. Deacetylation by HDAC1 represses its transactivation activity. Acetylated by KAT2A and KAT2B within a cluster of lysine residues between amino acids 129-133, this acetylation is strongly induced by glucocorticoid treatment and enhances transactivation activity.;Ubiquitinated, leading to proteasomal degradation.;Methylated. Methylation at Arg-3 by CARM1 and at Lys-43 by EHMT2 inhibit transactivation activity. Methylation is probably inhibited by phosphorylation at Thr-235.;O-glycosylated, glycosylation at Ser-227 and Ser-228 prevents phosphorylation on Thr-235, Ser-231 and Thr-226 and DNA binding activity which delays the adipocyte differentiation program.;Phosphorylated at Thr-235 by MAPK and CDK2, serves to prime phosphorylation at Thr-226 and Ser-231 by GSK3B and acquire DNA-binding as well as transactivation activities, required to induce adipogenesis. MAPK and CDK2 act sequentially to maintain Thr-235 in the primed phosphorylated state during mitotical cloning expansion and thereby progression of terminal differentiation. Phosphorylation at Thr-266 enhances transactivation activity. Phosphorylation at Ser-325 in response to calcium increases transactivation activity. Phosphorylated at Thr-235 by RPS6KA1 (PubMed:11684016).	Belongs to the bZIP family. C/EBP subfamily.	Tuberculosis;Senescence-Associated Secretory Phenotype (SASP);Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of granulopoiesis	PE1	20
+NX_P17677	Neuromodulin	238	24803	4.64	0	Cytoplasm;Filopodium membrane;Cell membrane;Growth cone membrane;Perikaryon;Synapse;Axon;Dendrite	NA	This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.	Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.;Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).;GAP43 is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the neuromodulin family.	L1CAM interactions	PE1	3
+NX_P17693	HLA class I histocompatibility antigen, alpha chain G	338	38224	5.47	1	Endoplasmic reticulum membrane;Filopodium membrane;Cell membrane;Early endosome;Secreted;Early endosome membrane	NA	Likely does not bind B2M and presents peptides.;Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).;Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).;Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:27859042). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799). Through interaction with KIR2DL4 receptor on decidual macrophages induces proinflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:11290782, PubMed:24453251). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251). May induce immune activation/suppression via intercellular membrane transfer (trogocytosis), likely enabling interaction with KIR2DL4, which resides mostly in endosomes (PubMed:20179272, PubMed:26460007). Through interaction with the inhibitory receptor CD160 on endothelial cells may control angiogenesis in immune privileged sites (PubMed:16809620).;Likely does not bind B2M and presents peptides.;Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).;Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799). Through interaction with KIR2DL4 receptor on decidual macrophages induces proinflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251).	N-glycosylated.;Soluble HLA class I histocompatibility antigen, alpha chain G: Produced by proteolytic cleavage at the cell surface (shedding) by matrix metalloproteinase MMP2.	Belongs to the MHC class I family.	Endocytosis;Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Type I diabetes mellitus;HTLV-I infection;Herpes simplex infection;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;Viral myocarditis;ER-Phagosome pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Endosomal/Vacuolar pathway;Interferon gamma signaling;Interferon alpha/beta signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC	PE1	6
+NX_P17706	Tyrosine-protein phosphatase non-receptor type 2	415	48473	8.51	0	Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Cell membrane;Endoplasmic reticulum;Nucleoplasm;Nucleus	NA	Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA.	Specifically phosphorylated in a cell cycle-dependent manner by cyclin-dependent kinases CDK1 and CDK2. Probably activated through phosphorylation by PKR.	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.	Regulation of IFNG signaling;Negative regulation of MET activity;Interleukin-37 signaling	PE1	18
+NX_P17707	S-adenosylmethionine decarboxylase proenzyme	334	38340	5.71	0	Nucleoplasm	NA	Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.	Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.	Belongs to the eukaryotic AdoMetDC family.	Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.;Cysteine and methionine metabolism;Arginine and proline metabolism;Metabolic pathways;Metabolism of polyamines	PE1	6
+NX_P17735	Tyrosine aminotransferase	454	50399	5.92	0	NA	Tyrosinemia 2	Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.	NA	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.;Ubiquinone and other terpenoid-quinone biosynthesis;Cysteine and methionine metabolism;Tyrosine metabolism;Phenylalanine metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis;Metabolic pathways;Tyrosine catabolism	PE1	16
+NX_P17752	Tryptophan 5-hydroxylase 1	444	50985	6.77	0	Cytosol	NA	NA	NA	Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.;Tryptophan metabolism;Metabolic pathways;Serotonin and melatonin biosynthesis	PE1	11
+NX_P17787	Neuronal acetylcholine receptor subunit beta-2	502	57019	6.33	4	Cell membrane;Postsynaptic cell membrane	Epilepsy, nocturnal frontal lobe, 3	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.	Neuroactive ligand-receptor interaction;Cholinergic synapse;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly sodium permeable acetylcholine nicotinic receptors;Highly calcium permeable nicotinic acetylcholine receptors	PE1	1
+NX_P17812	CTP synthase 1	591	66690	6.02	0	Cytosol;Cytoskeleton	Immunodeficiency 24	This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.	NA	Belongs to the CTP synthase family.	Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.;Pyrimidine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	1
+NX_P17813	Endoglin	658	70578	6.14	1	Nucleus;Cell membrane	Telangiectasia, hereditary hemorrhagic, 1	Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).	NA	NA	NA	PE1	9
+NX_P17844	Probable ATP-dependent RNA helicase DDX5	614	69148	9.06	0	Nucleoplasm;Nucleolus;Nucleus	NA	Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.	Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination.;Arg-502 is dimethylated, probably to asymmetric dimethylarginine.;Polyubiquitinated, leading to proteasomal degradation.	Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.	Spliceosome;mRNA Splicing - Major Pathway;Estrogen-dependent gene expression;SUMOylation of transcription cofactors	PE1	17
+NX_P17858	ATP-dependent 6-phosphofructokinase, liver type	780	85018	7.26	0	Cytoplasm	NA	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity).	GlcNAcylation at Ser-529 by OGT decreases enzyme activity, leading to redirect glucose flux through the oxidative pentose phosphate pathway. Glycosylation is stimulated by both hypoxia and glucose deprivation.	Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Fructose and mannose metabolism;Galactose metabolism;Metabolic pathways;Glycolysis;Neutrophil degranulation	PE1	21
+NX_P17861	X-box-binding protein 1	261	28695	9.71	1	Cytoplasm;Endoplasmic reticulum membrane;Membrane;Endoplasmic reticulum;Nucleus	Major affective disorder 7	Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Improves also glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity).;Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity).;Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ENR1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:2321018, PubMed:2196176, PubMed:1903538, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856).	X-box-binding protein 1, cytoplasmic form and luminal form are produced by intramembrane proteolytic cleavage of ER membrane-anchored isoform 1 triggered by HM13/SPP in a DERL1-RNF139-dependent and VCP/p97-independent manner. X-box-binding protein 1, luminal form is ubiquitinated leading to proteasomal degradation (PubMed:25239945).;Is deacetylated by SIRT1; deacetylation negatively regulates the transcriptional activity of XBP1 isoform 2 (PubMed:20955178).;Is ubiquitinated, leading to proteasome-mediated degradation in response to ER stress (PubMed:11779464, PubMed:16461360, PubMed:25239945).;Is acetylated by EP300; acetylation positively regulates the transcriptional activity of XBP1 isoform 2 (PubMed:20955178).	Belongs to the bZIP family.	Protein processing in endoplasmic reticulum;HTLV-I infection;XBP1(S) activates chaperone genes;IRE1alpha activates chaperones;ATF6 (ATF6-alpha) activates chaperone genes	PE1	22
+NX_P17900	Ganglioside GM2 activator	193	20838	5.17	0	Lysosome	GM2-gangliosidosis AB	The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.	The serines in positions 32 and 33 are absent in 80% of the sequenced protein.	NA	Lysosome;Glycosphingolipid metabolism;Neutrophil degranulation	PE1	5
+NX_P17927	Complement receptor type 1	2039	223663	6.57	1	Membrane	NA	(Microbial infection) Acts as a receptor for Epstein-Barr virus.;Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728).	NA	Belongs to the receptors of complement activation (RCA) family.	Complement and coagulation cascades;Hematopoietic cell lineage;Legionellosis;Leishmaniasis;Malaria;Tuberculosis;Regulation of Complement cascade;Neutrophil degranulation;RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	PE1	1
+NX_P17931	Galectin-3	250	26152	8.58	0	Cytoplasm;Cell membrane;Secreted;Nucleoplasm;Cytosol;Nucleus	NA	Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.	NA	NA	Advanced glycosylation endproduct receptor signaling;Neutrophil degranulation;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX2 regulates genes involved in differentiation of myeloid cells	PE1	14
+NX_P17936	Insulin-like growth factor-binding protein 3	291	31674	9.03	0	Nucleoplasm;Cytosol;Secreted;Cytoplasmic vesicle	NA	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.	Phosphorylated by FAM20C in the extracellular medium.	NA	p53 signaling pathway;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);TP53 Regulates Transcription of Death Receptors and Ligands;Post-translational protein phosphorylation	PE1	7
+NX_P17947	Transcription factor PU.1	270	31083	6.31	0	Nucleoplasm;Nucleus	NA	Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity).	SPI1 is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the ETS family.	Osteoclast differentiation;HTLV-I infection;Pathways in cancer;Acute myeloid leukemia;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Transcriptional regulation of granulopoiesis	PE1	11
+NX_P17948	Vascular endothelial growth factor receptor 1	1338	150769	8.66	1	Cytoplasm;Cell membrane;Secreted;Endosome;Cytoskeleton	NA	Phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1.;Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.;Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL.	N-glycosylated.;Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation.;Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. One subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-1169 is important for interaction with PLCG. Phosphorylation at Tyr-1213 is important for interaction with PIK3R1, PTPN11, GRB2, and PLCG. Phosphorylation at Tyr-1333 is important for endocytosis and for interaction with CBL, NCK1 and CRK. Is probably dephosphorylated by PTPRB.;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Cytokine-cytokine receptor interaction;Endocytosis;Focal adhesion;Rheumatoid arthritis;Neurophilin interactions with VEGF and VEGFR;VEGF binds to VEGFR leading to receptor dimerization	PE1	13
+NX_P17980	26S proteasome regulatory subunit 6A	439	49204	5.13	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.	Sumoylated by UBE2I in response to MEKK1-mediated stimuli.	Belongs to the AAA ATPase family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	11
+NX_P17987	T-complex protein 1 subunit alpha	556	60344	5.8	0	Cytoplasm;Cytosol;Centrosome	NA	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).	NA	Belongs to the TCP-1 chaperonin family.	BBSome-mediated cargo-targeting to cilium;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	6
+NX_P18031	Tyrosine-protein phosphatase non-receptor type 1	435	49967	5.88	0	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.	Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.;Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50.;S-nitrosylation of Cys-215 inactivates the enzyme activity.;Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.;PTPN1 is phosphorylated by INSR (Phosphotyrosine:PTM-0255)	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.	Adherens junction;Insulin signaling pathway;Regulation of IFNA signaling;Growth hormone receptor signaling;Integrin alphaIIb beta3 signaling;Regulation of IFNG signaling;PTK6 Down-Regulation;Negative regulation of MET activity;MECP2 regulates neuronal receptors and channels	PE1	20
+NX_P18054	Arachidonate 12-lipoxygenase, 12S-type	663	75694	5.82	0	Membrane;Cytosol;Nucleus speckle	Esophageal cancer;Colorectal cancer	Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:17493578, PubMed:1851637, PubMed:8319693, PubMed:8500694, PubMed:18311922). Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid (PubMed:8250832, PubMed:17493578, PubMed:22984144, PubMed:24282679, PubMed:8319693, PubMed:8500694). In contrast does not react towards methyl esters of linoleic and arachidonic acids (By similarity). Also catalyzes the epoxidation of double bonds of polyunsaturated fatty acids such as 14S-hydroperoxy-docosahexaenoate (DHA) resulting in the formation of (13S,14S)-epoxy-DHA (PubMed:23504711). Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4 (PubMed:8250832). Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:8319693, PubMed:8500694). It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor (PubMed:9751607, PubMed:16638750). Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance (PubMed:23578768). May also play a role in the control of cell migration and proliferation (PubMed:22237009).	NA	Belongs to the lipoxygenase family.	Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.;Arachidonic acid metabolism;Metabolic pathways;Synthesis of Lipoxins (LX);Synthesis of 12-eicosatetraenoic acid derivatives;Synthesis of Hepoxilins (HX) and Trioxilins (TrX);Biosynthesis of DHA-derived SPMs;Biosynthesis of DPAn-6 SPMs;Biosynthesis of DPAn-3-derived maresins	PE1	17
+NX_P18065	Insulin-like growth factor-binding protein 2	325	34814	7.48	0	Endoplasmic reticulum;Secreted	NA	Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.	O-glycosylated.	NA	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	PE1	2
+NX_P18074	General transcription and DNA repair factor IIH helicase subunit XPD	760	86909	6.72	0	Nucleoplasm;Cytosol;Spindle;Nucleus	Cerebro-oculo-facio-skeletal syndrome 2;Xeroderma pigmentosum complementation group D;Trichothiodystrophy 1, photosensitive	ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.	ISGylated.	Belongs to the helicase family. RAD3/XPD subfamily.	Basal transcription factors;Nucleotide excision repair;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Tat-mediated elongation of the HIV-1 transcript;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Cytosolic iron-sulfur cluster assembly;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;TP53 Regulates Transcription of DNA Repair Genes	PE1	19
+NX_P18075	Bone morphogenetic protein 7	431	49313	7.74	0	Nucleoplasm;Secreted;Nucleolus;Cytoplasmic vesicle	NA	Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.	Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.	Belongs to the TGF-beta family.	Cytokine-cytokine receptor interaction;Hedgehog signaling pathway;TGF-beta signaling pathway;Molecules associated with elastic fibres	PE1	20
+NX_P18077	60S ribosomal protein L35a	110	12538	11.07	0	NA	Diamond-Blackfan anemia 5	Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.	NA	Belongs to the eukaryotic ribosomal protein eL33 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	3
+NX_P18084	Integrin beta-5	799	88054	5.72	1	Membrane;Mitochondrion;Cell membrane	NA	Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.;(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.	NA	Belongs to the integrin beta chain family.	Phagosome;Focal adhesion;ECM-receptor interaction;Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Syndecan interactions;Integrin cell surface interactions;ECM proteoglycans;Molecules associated with elastic fibres;Smooth Muscle Contraction;Cross-presentation of particulate exogenous antigens (phagosomes)	PE1	3
+NX_P18085	ADP-ribosylation factor 4	180	20511	6.6	0	Membrane;Golgi apparatus	NA	GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.	NA	Belongs to the small GTPase superfamily. Arf family.	VxPx cargo-targeting to cilium;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	3
+NX_P18089	Alpha-2B adrenergic receptor	450	49954	8.8	7	Cell membrane	Epilepsy, familial adult myoclonic, 2	Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.	NA	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;G alpha (z) signalling events;Adrenoceptors;Adrenaline signalling through Alpha-2 adrenergic receptor	PE1	2
+NX_P18124	60S ribosomal protein L7	248	29226	10.66	0	Endoplasmic reticulum;Cytosol;Nucleolus	NA	Component of the large ribosomal subunit (PubMed:12962325). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.	NA	Belongs to the universal ribosomal protein uL30 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	8
+NX_P18146	Early growth response protein 1	543	57507	8.51	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).	NA	Belongs to the EGR C2H2-type zinc-finger protein family.	Interferon alpha/beta signaling;Regulation of PTEN gene transcription	PE1	5
+NX_P18206	Vinculin	1134	123799	5.5	0	Cytoplasm;Cell membrane;Adherens junction;Focal adhesion;Sarcolemma;Cytoskeleton	Cardiomyopathy, familial hypertrophic 15;Cardiomyopathy, dilated 1W	Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.	Phosphorylated; on serines, threonines and tyrosines. Phosphorylation on Tyr-1133 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques (By similarity).;Acetylated; mainly by myristic acid but also by a small amount of palmitic acid.	Belongs to the vinculin/alpha-catenin family.	Focal adhesion;Adherens junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Shigellosis;Amoebiasis;MAP2K and MAPK activation;Platelet degranulation;Smooth Muscle Contraction;Neutrophil degranulation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	10
+NX_P18283	Glutathione peroxidase 2	190	21954	7.64	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.	NA	Belongs to the glutathione peroxidase family.	Glutathione metabolism;Arachidonic acid metabolism;Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Synthesis of 15-eicosatetraenoic acid derivatives;Synthesis of 12-eicosatetraenoic acid derivatives;Synthesis of 5-eicosatetraenoic acids	PE1	14
+NX_P18405	3-oxo-5-alpha-steroid 4-dehydrogenase 1	259	29459	9.19	5	Microsome membrane;Endoplasmic reticulum membrane	NA	Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	NA	Belongs to the steroid 5-alpha reductase family.	Steroid hormone biosynthesis;Androgen biosynthesis	PE1	5
+NX_P18428	Lipopolysaccharide-binding protein	481	53384	6.23	0	Cytoplasmic granule membrane;Secreted	NA	Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).	NA	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Toll-like receptor signaling pathway;Salmonella infection;Tuberculosis;Toll Like Receptor 4 (TLR4) Cascade;Transfer of LPS from LBP carrier to CD14;Regulation of TLR by endogenous ligand;Interleukin-4 and Interleukin-13 signaling	PE1	20
+NX_P18433	Receptor-type tyrosine-protein phosphatase alpha	802	90719	6.23	1	Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.	RAF/MAP kinase cascade;NCAM signaling for neurite out-growth	PE1	20
+NX_P18440	Arylamine N-acetyltransferase 1	290	33899	6.09	0	Cytoplasm	NA	Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.	NA	Belongs to the arylamine N-acetyltransferase family.	Caffeine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Acetylation	PE1	8
+NX_P18505	Gamma-aminobutyric acid receptor subunit beta-1	474	54235	8.88	4	Cell membrane;Postsynaptic cell membrane	Epileptic encephalopathy, early infantile, 45	Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;Signaling by ERBB4;GABA receptor activation	PE1	4
+NX_P18507	Gamma-aminobutyric acid receptor subunit gamma-2	467	54162	8.72	4	Cytoplasmic vesicle membrane;Dendrite;Cell membrane;Postsynaptic cell membrane	Febrile seizures, familial, 8;Epileptic encephalopathy, early infantile, 74;Epilepsy, childhood absence 2;Generalized epilepsy with febrile seizures plus 3	Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2538761, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750, PubMed:27864268). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).	Glycosylated.;Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability.	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;Signaling by ERBB4;GABA receptor activation	PE1	5
+NX_P18509	Pituitary adenylate cyclase-activating polypeptide	176	18835	9.83	0	Secreted	NA	Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).	NA	Belongs to the glucagon family.	G alpha (s) signalling events;Glucagon-type ligand receptors;NGF-independant TRKA activation	PE1	18
+NX_P18510	Interleukin-1 receptor antagonist protein	177	20055	5.83	0	Cytoplasm;Secreted;Nucleoplasm;Centrosome;Cytosol	Interleukin 1 receptor antagonist deficiency;Microvascular complications of diabetes 4	Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.	NA	NA	Interleukin-10 signaling;Interleukin-1 signaling	PE1	2
+NX_P18545	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	87	9643	9.52	0	NA	Retinitis pigmentosa 57	Participates in processes of transmission and amplification of the visual signal. CGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.	NA	Belongs to the rod/cone cGMP-PDE gamma subunit family.	Purine metabolism;Phototransduction;Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Ca2+ pathway	PE1	17
+NX_P18564	Integrin beta-6	788	85936	5.34	1	Cell junction;Focal adhesion;Membrane;Nucleoplasm;Centrosome	Amelogenesis imperfecta 1H	(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260).;Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447).;(Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.	NA	Belongs to the integrin beta chain family.	Focal adhesion;ECM-receptor interaction;Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Integrin cell surface interactions;ECM proteoglycans;Molecules associated with elastic fibres;Elastic fibre formation	PE1	2
+NX_P18577	Blood group Rh(CE) polypeptide	417	45560	9.45	11	Membrane	Rh-null, amorph type	May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.	NA	Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.	Rhesus blood group biosynthesis	PE1	1
+NX_P18583	Protein SON	2426	263830	5.5	0	Nucleus speckle;Nucleus	ZTTK syndrome	RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680).	NA	NA	NA	PE1	21
+NX_P18615	Negative elongation factor E	380	43240	9.36	0	Nucleoplasm;Nucleus	NA	(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.;Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27282391).	Sumoylated.	Belongs to the RRM NELF-E family.	Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes	PE1	6
+NX_P18621	60S ribosomal protein L17	184	21397	10.18	0	Endoplasmic reticulum;Cytosol	NA	Component of the large ribosomal subunit.	NA	Belongs to the universal ribosomal protein uL22 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	18
+NX_P18627	Lymphocyte activation gene 3 protein	525	57449	8.14	1	Secreted;Cell membrane	NA	Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185).;Secreted lymphocyte activation gene 3 protein: May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.	Lymphocyte activation gene 3 protein: Proteolytically cleaved by ADAM10 and ADAM17 within the connecting peptide region, leading to release of Secreted lymphocyte activation gene 3 protein (sLAG-3). ADAM10 mediates constitutive cleavage, but cleavage increases following T-cell activation, whereas shedding by ADAM17 is induced by TCR signaling in a PRKCQ-dependent manner.	Belongs to the LAG3 family.	MHC class II antigen presentation	PE1	12
+NX_P18669	Phosphoglycerate mutase 1	254	28804	6.67	0	NA	NA	Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.	Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.;PGAM1 is phosphorylated by MAPK3	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.	Glycolysis / Gluconeogenesis;Metabolic pathways;Glycolysis;Gluconeogenesis;Neutrophil degranulation	PE1	10
+NX_P18754	Regulator of chromosome condensation	421	44969	7.18	0	Cytoplasm;Nucleus membrane;Chromosome;Nucleoplasm;Nucleus	NA	Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:1944575, PubMed:17435751, PubMed:20668449, PubMed:22215983, PubMed:11336674). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580).	N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Di- and trimethylation produce a permanent positive charge on the amino group, which facilitates electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran.;RCC1 is phosphorylated by MAPK3	NA	Rev-mediated nuclear export of HIV RNA;Nuclear import of Rev protein	PE1	1
+NX_P18825	Alpha-2C adrenergic receptor	462	49522	10.32	7	Cell membrane	NA	Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.	NA	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (z) signalling events;Adrenoceptors;Adrenaline signalling through Alpha-2 adrenergic receptor;Surfactant metabolism	PE1	4
+NX_P18827	Syndecan-1	310	32462	4.53	1	Membrane;Extracellular exosome;Focal adhesion;Secreted	NA	Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).	Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.	Belongs to the syndecan proteoglycan family.	ECM-receptor interaction;Cell adhesion molecules (CAMs);Malaria;Retinoid metabolism and transport;HS-GAG biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Syndecan interactions;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Cell surface interactions at the vascular wall;Defective B3GALT6 causes EDSP2 and SEMDJL1;Other interleukin signaling	PE1	2
+NX_P18846	Cyclic AMP-dependent transcription factor ATF-1	271	29233	8.44	0	Nucleoplasm;Nucleus	Angiomatoid fibrous histiocytoma	This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.	Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.;ATF1 is phosphorylated by CSNK2A1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the bZIP family. ATF subfamily.	HTLV-I infection;CREB phosphorylation	PE1	12
+NX_P18847	Cyclic AMP-dependent transcription factor ATF-3	181	20576	8.8	0	Nucleoplasm;Nucleolus;Nucleus	NA	Activates transcription presumably by sequestering inhibitory cofactors away from the promoters.;This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter.	NA	Belongs to the bZIP family. ATF subfamily.	HTLV-I infection;ATF4 activates genes in response to endoplasmic reticulum stress	PE1	1
+NX_P18848	Cyclic AMP-dependent transcription factor ATF-4	351	38590	4.83	0	Cytoplasm;Cell membrane;Centriolar satellite;Centrosome;Cytosol;Nucleus	NA	Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).	Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4.;Phosphorylated by NEK6.;Phosphorylated by NEK6 (By similarity). Phosphorylated on the betaTrCP degron motif at Ser-219, followed by phosphorylation at Thr-213, Ser-224, Ser-231, Ser-235 and Ser-248, promoting interaction with BTRC and ubiquitination. Phosphorylation is promoted by mTORC1 (By similarity).;ATF4 is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the bZIP family.	MAPK signaling pathway;Protein processing in endoplasmic reticulum;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;GnRH signaling pathway;HTLV-I infection;Prostate cancer;ATF4 activates genes in response to endoplasmic reticulum stress;PERK regulates gene expression;ATF6 (ATF6-alpha) activates chaperone genes	PE1	22
+NX_P18850	Cyclic AMP-dependent transcription factor ATF-6 alpha	670	74585	8.36	1	Endoplasmic reticulum membrane;Nucleus	Achromatopsia 7	Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.	N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to trigger the unfolded protein response (UPR).;Phosphorylated in vitro by MAPK14/P38MAPK.;During unfolded protein response, a fragment of approximately 50 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases.	Belongs to the bZIP family. ATF subfamily.	Protein processing in endoplasmic reticulum;Alzheimer's disease;ATF4 activates genes in response to endoplasmic reticulum stress;ATF6 (ATF6-alpha) activates chaperones;ATF6 (ATF6-alpha) activates chaperone genes	PE1	1
+NX_P18858	DNA ligase 1	919	101736	5.49	0	Golgi apparatus;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.	NA	Belongs to the ATP-dependent DNA ligase family.	DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);POLB-Dependent Long Patch Base Excision Repair;PCNA-Dependent Long Patch Base Excision Repair;Processive synthesis on the C-strand of the telomere;Processive synthesis on the lagging strand;Early Phase of HIV Life Cycle;Gap-filling DNA repair synthesis and ligation in TC-NER;Gap-filling DNA repair synthesis and ligation in GG-NER	PE1	19
+NX_P18859	ATP synthase-coupling factor 6, mitochondrial	108	12588	9.52	0	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.	NA	Belongs to the eukaryotic ATPase subunit F6 family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	21
+NX_P18887	DNA repair protein XRCC1	633	69477	6.02	0	Nucleoplasm;Nucleus	Spinocerebellar ataxia, autosomal recessive, 26	Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.	Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.;Sumoylated.	NA	Base excision repair;Resolution of AP sites via the single-nucleotide replacement pathway;APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through MMEJ (alt-NHEJ);Gap-filling DNA repair synthesis and ligation in GG-NER	PE1	19
+NX_P19012	Keratin, type I cytoskeletal 15	456	49212	4.71	0	Nucleoplasm;Cytoskeleton	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_P19013	Keratin, type II cytoskeletal 4	534	57285	6.25	0	Cytoskeleton	White sponge nevus 1	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_P19021	Peptidyl-glycine alpha-amidating monooxygenase	973	108332	5.98	1	Golgi apparatus;Secreted;Membrane;Secretory vesicle membrane;Cytosol	NA	Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides (PubMed:12699694). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monoxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate (PubMed:12699694). The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate (PubMed:12699694). Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (By similarity).	NA	In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.;In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.	NA	PE1	5
+NX_P19022	Cadherin-2	906	99809	4.64	1	Cell surface;Cell junction;Sarcolemma;Cell membrane	NA	Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.	Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).;May be phosphorylated by OBSCN.;CDH2 is phosphorylated by MAPK3	NA	Cell adhesion molecules (CAMs);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Adherens junctions interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Myogenesis	PE1	18
+NX_P19075	Tetraspanin-8	237	26044	5.48	4	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	12
+NX_P19086	Guanine nucleotide-binding protein G(z) subunit alpha	355	40924	7.53	0	Membrane;Cytoplasmic vesicle	NA	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.	NA	Belongs to the G-alpha family. G(i/o/t/z) subfamily.	Long-term depression;G alpha (i) signalling events;G alpha (s) signalling events;G-protein activation;G alpha (z) signalling events;PLC beta mediated events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	22
+NX_P19087	Guanine nucleotide-binding protein G(t) subunit alpha-2	354	40176	5.1	0	NA	Achromatopsia 4	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.	NA	Belongs to the G-alpha family. G(i/o/t/z) subfamily.	Phototransduction;G alpha (i) signalling events;G-protein activation;Ca2+ pathway;PLC beta mediated events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	1
+NX_P19099	Cytochrome P450 11B2, mitochondrial	503	57560	9.47	0	Mitochondrion inner membrane	Hyperaldosteronism, familial, 1;Corticosterone methyloxidase 2 deficiency;Corticosterone methyloxidase 1 deficiency	A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone (PubMed:11856349, PubMed:23322723, PubMed:1594605, PubMed:9814506). Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21-hydroxyprogesterone, namely 11-beta hydroxylation followed with two successive oxidations at C18 to yield 18-hydroxy and then 18-aldehyde derivatives, resulting in the formation of aldosterone (PubMed:11856349, PubMed:23322723, PubMed:1594605, PubMed:9814506). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:11856349, PubMed:23322723, PubMed:1594605, PubMed:9814506).	NA	Belongs to the cytochrome P450 family.	Steroid biosynthesis.;Steroid hormone biosynthesis;Metabolic pathways;Endogenous sterols;Glucocorticoid biosynthesis;Mineralocorticoid biosynthesis;Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)	PE1	8
+NX_P19105	Myosin regulatory light chain 12A	171	19794	4.67	0	NA	NA	Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).	Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity).	NA	Focal adhesion;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Ephrin signaling;Smooth Muscle Contraction	PE1	18
+NX_P19113	Histidine decarboxylase	662	74141	8.3	0	Nucleus	NA	Catalyzes the biosynthesis of histamine from histidine.	NA	Belongs to the group II decarboxylase family.	Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1.;Histidine metabolism;Metabolic pathways;Histidine catabolism	PE1	15
+NX_P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	1290	148532	5.73	0	Ruffle;Cytosol;Lamellipodium	NA	Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.	Ubiquitinated by CBLB in activated T-cells.;Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells.;PLCG1 is phosphorylated by FGFR4;PLCG1 is phosphorylated by PRKD1 (Phosphoserine:PTM-0253);PLCG1 is phosphorylated by KDR (Phosphotyrosine:PTM-0255);PLCG1 is phosphorylated by FGFR3;PLCG1 is phosphorylated by FGFR1 (Phosphotyrosine:PTM-0255);PLCG1 is phosphorylated by TXK (Phosphotyrosine:PTM-0255);PLCG1 is phosphorylated by FGFR2	NA	Inositol phosphate metabolism;Metabolic pathways;ErbB signaling pathway;Calcium signaling pathway;Phosphatidylinositol signaling system;VEGF signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Glioma;Non-small cell lung cancer;ISG15 antiviral mechanism;Generation of second messenger molecules;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;Phospholipase C-mediated cascade, FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Role of second messengers in netrin-1 signaling;Role of phospholipids in phagocytosis;Synthesis of IP3 and IP4 in the cytosol;PECAM1 interactions;VEGFR2 mediated cell proliferation;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Downstream signal transduction;Constitutive Signaling by EGFRvIII;Signaling by FGFR4 in disease;DAG and IP3 signaling;PLC-gamma1 signalling;PLCG1 events in ERBB2 signaling;EGFR interacts with phospholipase C-gamma;Signaling by FGFR3 point mutants in cancer;RET signaling;Activated NTRK2 signals through PLCG1;Activated NTRK3 signals through PLCG1;Erythropoietin activates Phospholipase C gamma (PLCG)	PE1	20
+NX_P19224	UDP-glucuronosyltransferase 1-6	532	60751	8.66	1	Endoplasmic reticulum membrane;Microsome	NA	Lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).;UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	2
+NX_P19235	Erythropoietin receptor	508	55065	4.64	1	Nucleus speckle;Secreted;Cell membrane	Erythrocytosis, familial, 1	Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.;Acts as a dominant-negative receptor of EPOR-mediated signaling.	On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Phosphorylation on Tyr-454 is required for PTPN6 interaction, Tyr-426 for PTPN11. Tyr-426 is also required for SOCS3 binding, but Tyr-454/Tyr-456 motif is the preferred binding site.;Ubiquitination at Lys-281 mediates receptor internalization, whereas ubiquitination at Lys-453 promotes trafficking of activated receptors to the lysosomes for degradation (By similarity). Ubiquitinated by NOSIP; appears to be either multi-monoubiquitinated or polyubiquitinated. Ubiquitination mediates proliferation and survival of EPO-dependent cells.;EPOR is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	Belongs to the type I cytokine receptor family. Type 1 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Erythropoietin activates RAS;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Signaling by Erythropoietin;Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5	PE1	19
+NX_P19237	Troponin I, slow skeletal muscle	187	21692	9.61	0	Nucleoplasm;Nucleolus;Nucleus	NA	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	NA	Belongs to the troponin I family.	Striated Muscle Contraction	PE1	1
+NX_P19256	Lymphocyte function-associated antigen 3	250	28147	6.3	1	Cell membrane	NA	Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.	NA	NA	Cell adhesion molecules (CAMs);Cell surface interactions at the vascular wall;Neutrophil degranulation	PE1	1
+NX_P19320	Vascular cell adhesion protein 1	739	81276	5.14	1	Membrane;Cell junction	NA	Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.	Sialoglycoprotein.	NA	Cell adhesion molecules (CAMs);Leukocyte transendothelial migration;African trypanosomiasis;Malaria;HTLV-I infection;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Interferon gamma signaling;Integrin cell surface interactions;Interleukin-4 and Interleukin-13 signaling	PE1	1
+NX_P19338	Nucleolin	710	76614	4.6	0	Nucleoplasm;Cytoplasm;Nucleus;Nucleolus	NA	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.	Symmetrically methylated by PRMT5.;Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).	NA	Pathogenic Escherichia coli infection;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	2
+NX_P19367	Hexokinase-1	917	102486	6.36	0	Mitochondrion outer membrane;Cytosol;Mitochondrion	Retinitis pigmentosa 79;Hexokinase deficiency;Neuropathy, hereditary motor and sensory, Russe type	Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331).	NA	Belongs to the hexokinase family.	Carbohydrate metabolism; hexose metabolism.;Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.;Glycolysis / Gluconeogenesis;Fructose and mannose metabolism;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Butirosin and neomycin biosynthesis;Metabolic pathways;Insulin signaling pathway;Type II diabetes mellitus;Carbohydrate digestion and absorption;Glycolysis;Defective HK1 causes hexokinase deficiency (HK deficiency)	PE1	10
+NX_P19387	DNA-directed RNA polymerase II subunit RPB3	275	31441	4.79	0	Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).	NA	Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Huntington's disease;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;MicroRNA (miRNA) biogenesis;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	16
+NX_P19388	DNA-directed RNA polymerases I, II, and III subunit RPABC1	210	24551	5.69	0	Nucleoplasm;Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).	NA	Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Huntington's disease;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Cytosolic sensors of pathogen-associated DNA;MicroRNA (miRNA) biogenesis;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	19
+NX_P19397	Leukocyte surface antigen CD53	219	24341	7.48	4	Membrane;Cell junction;Cell membrane	NA	Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).	NA	Belongs to the tetraspanin (TM4SF) family.	Neutrophil degranulation	PE1	1
+NX_P19404	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	249	27392	8.22	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 7	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).	NA	Belongs to the complex I 24 kDa subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	18
+NX_P19419	ETS domain-containing protein Elk-1	428	44888	6.42	0	Nucleoplasm;Nucleus	NA	Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).	Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.;On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1 (By similarity).;ELK1 is phosphorylated by MAPK14 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);ELK1 is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);ELK1 is phosphorylated by MAPK11 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the ETS family.	MAPK signaling pathway;ErbB signaling pathway;Focal adhesion;Insulin signaling pathway;GnRH signaling pathway;Prion diseases;Leishmaniasis;HTLV-I infection;Endometrial cancer;ERK/MAPK targets;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	X
+NX_P19429	Troponin I, cardiac muscle	210	24008	9.87	0	Cytoplasmic vesicle;Cytosol	Cardiomyopathy, familial restrictive 1;Cardiomyopathy, familial hypertrophic 7;Cardiomyopathy, dilated 2A;Cardiomyopathy, dilated 1FF	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity). Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).;TNNI3 is phosphorylated by PRKCE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the troponin I family.	Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Striated Muscle Contraction;Ion homeostasis	PE1	19
+NX_P19438	Tumor necrosis factor receptor superfamily member 1A	455	50495	6.23	1	Cell membrane;Secreted;Golgi apparatus membrane	Multiple sclerosis 5;Familial hibernian fever	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.	The soluble form is produced from the membrane form by proteolytic processing.	NA	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Apoptosis;Osteoclast differentiation;Adipocytokine signaling pathway;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Hepatitis C;Influenza A;HTLV-I infection;Herpes simplex infection;TNFs bind their physiological receptors;TNFR1-induced proapoptotic signaling;TNF signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production;Interleukin-10 signaling	PE1	12
+NX_P19440	Glutathione hydrolase 1 proenzyme	569	61410	6.65	1	Cell membrane	Glutathionuria	Seems to be inactive.;Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism.	Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme.;N-glycosylated on both chains. Contains hexoses, hexosamines and sialic acid residues. Glycosylation profiles tested in kidney and liver tissues reveal the presence of tissue-specific and site-specific glycan composition, despite the overlap in composition among the N-glycans. A total of 36 glycan compositions, with 40 unique structures are observed. Up to 15 different glycans are observed at a single site, with site-specific variation in glycan composition. The difference in glycosylation profiles in the 2 tissues do not affect the enzyme activity.	Belongs to the gamma-glutamyltransferase family.	Sulfur metabolism; glutathione metabolism.;Taurine and hypotaurine metabolism;Cyanoamino acid metabolism;Glutathione metabolism;Arachidonic acid metabolism;Metabolic pathways;Aflatoxin activation and detoxification;Glutathione synthesis and recycling;Synthesis of Leukotrienes (LT) and Eoxins (EX);Defective GGT1 causes Glutathionuria (GLUTH);Defective GGT1 causes Glutathionuria (GLUTH)	PE1	22
+NX_P19447	General transcription and DNA repair factor IIH helicase subunit XPB	782	89278	6.83	0	Nucleoplasm;Nucleus	Xeroderma pigmentosum complementation group B;Trichothiodystrophy 2, photosensitive	ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.	NA	Belongs to the helicase family. RAD25/XPB subfamily.	Basal transcription factors;Nucleotide excision repair;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Tat-mediated elongation of the HIV-1 transcript;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;TP53 Regulates Transcription of DNA Repair Genes	PE1	2
+NX_P19474	E3 ubiquitin-protein ligase TRIM21	475	54170	5.98	0	Cytoplasm;Nucleoplasm;Autophagosome;P-body;Nucleus	NA	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).	Autoubiquitinated; does not lead to its proteasomal degradation. Deubiquitinated by USP4; leading to its stabilization.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Systemic lupus erythematosus;Antigen processing: Ubiquitination &amp; Proteasome degradation;Interferon gamma signaling;STING mediated induction of host immune responses;Regulation of innate immune responses to cytosolic DNA	PE1	11
+NX_P19484	Transcription factor EB	476	52865	5.87	0	Cytoplasm;Nucleus	NA	Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937).	Sumoylated; does not affect dimerization with MITF.	Belongs to the MiT/TFE family.	NA	PE1	6
+NX_P19525	Interferon-induced, double-stranded RNA-activated protein kinase	551	62094	8.58	0	Cytoplasm;Cytosol;Perinuclear region;Nucleus	NA	IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin.	Autophosphorylated on several Ser, Thr and Tyr residues. Autophosphorylation of Thr-451 is dependent on Thr-446 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads to the activation of the kinase. Tyrosine autophosphorylation is essential for efficient dsRNA-binding, dimerization, and kinase activation.;EIF2AK2 is phosphorylated by JAK1 (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.	Protein processing in endoplasmic reticulum;Hepatitis C;Measles;Influenza A;Herpes simplex infection;ISG15 antiviral mechanism;Inhibition of PKR	PE1	2
+NX_P19526	Galactoside 2-alpha-L-fucosyltransferase 1	365	41251	6.92	1	Golgi stack membrane	NA	Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway.	NA	Belongs to the glycosyltransferase 11 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Glycosphingolipid biosynthesis - globo series;Metabolic pathways;ABO blood group biosynthesis	PE1	19
+NX_P19532	Transcription factor E3	575	61521	5.41	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') (By similarity). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937).	Sumoylated; does not affect dimerization with MITF.	Belongs to the MiT/TFE family.	NA	PE1	X
+NX_P19544	Wilms tumor protein	449	49188	9.23	0	Cytoplasm;Nucleus speckle;Nucleolus;Nucleoplasm;Nucleus	Nephrotic syndrome 4;Frasier syndrome;Mesothelioma, malignant;Denys-Drash syndrome;Wilms tumor 1;Meacham syndrome	Has lower affinity for DNA, and can bind RNA (PubMed:19123921).;Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801).	NA	Belongs to the EGR C2H2-type zinc-finger protein family.	NA	PE1	11
+NX_P19622	Homeobox protein engrailed-2	333	34211	9.49	0	Nucleoplasm;Nucleolus;Nucleus	NA	NA	NA	Belongs to the engrailed homeobox family.	NA	PE1	7
+NX_P19623	Spermidine synthase	302	33825	5.3	0	Nucleoplasm;Cytosol	NA	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.	NA	Belongs to the spermidine/spermine synthase family.	Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.;Cysteine and methionine metabolism;Arginine and proline metabolism;beta-Alanine metabolism;Glutathione metabolism;Metabolic pathways;Metabolism of polyamines	PE1	1
+NX_P19634	Sodium/hydrogen exchanger 1	815	90763	6.74	12	Membrane;Endoplasmic reticulum membrane;Cell membrane	Lichtenstein-Knorr syndrome	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.	Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1 (By similarity).;O-glycosylated.	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Cardiac muscle contraction;Regulation of actin cytoskeleton;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;Hyaluronan uptake and degradation;Sodium/Proton exchangers	PE1	1
+NX_P19652	Alpha-1-acid glycoprotein 2	201	23603	5.03	0	Secreted	NA	Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.	N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).	Belongs to the calycin superfamily. Lipocalin family.	Platelet degranulation;Neutrophil degranulation	PE1	9
+NX_P19784	Casein kinase II subunit alpha'	350	41213	8.65	0	NA	NA	Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.	Ribosome biogenesis in eukaryotes;Wnt signaling pathway;Adherens junction;Tight junction;Measles;Herpes simplex infection;Synthesis of PC;Signal transduction by L1;Condensation of Prometaphase Chromosomes;WNT mediated activation of DVL;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Regulation of TP53 Activity through Phosphorylation;Receptor Mediated Mitophagy;Regulation of PTEN stability and activity;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	16
+NX_P19793	Retinoic acid receptor RXR-alpha	462	50811	7.92	0	Golgi apparatus;Cytoplasm;Mitochondrion;Nucleoplasm;Nucleus	NA	Receptor for retinoic acid that acts as a transcription factor (PubMed:11162439, PubMed:11915042). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:28167758, PubMed:17761950, PubMed:16107141, PubMed:18800767, PubMed:19167885). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632).	Acetylated by EP300; acetylation enhances DNA binding and transcriptional activity.;Phosphorylated on serine and threonine residues mainly in the N-terminal modulating domain (By similarity). Constitutively phosphorylated on Ser-21 in the presence or absence of ligand (By similarity). Under stress conditions, hyperphosphorylated by activated JNK on Ser-56, Ser-70, Thr-82 and Ser-260 (By similarity). Phosphorylated on Ser-27, in vitro, by PKA (PubMed:11162439). This phosphorylation is required for repression of cAMP-mediated transcriptional activity of RARA (PubMed:11162439).;Sumoylation negatively regulates transcriptional activity. Desumoylated specifically by SENP6.	Belongs to the nuclear hormone receptor family. NR2 subfamily.	PPAR signaling pathway;Adipocytokine signaling pathway;Bile secretion;Hepatitis C;Pathways in cancer;Thyroid cancer;Small cell lung cancer;Non-small cell lung cancer;PPARA activates gene expression;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Nuclear Receptor transcription pathway;Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex;Endogenous sterols;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Import of palmitoyl-CoA into the mitochondrial matrix;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Recycling of bile acids and salts;Synthesis of bile acids and bile salts;Activation of anterior HOX genes in hindbrain development during early embryogenesis;SUMOylation of intracellular receptors;Transcriptional regulation of granulopoiesis	PE1	9
+NX_P19801	Amiloride-sensitive amine oxidase [copper-containing]	751	85378	6.6	0	Extracellular space	NA	Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.	Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.	Belongs to the copper/topaquinone oxidase family.	Arginine and proline metabolism;Histidine metabolism;Tryptophan metabolism;Phase I - Functionalization of compounds;Neutrophil degranulation	PE1	7
+NX_P19823	Inter-alpha-trypsin inhibitor heavy chain H2	946	106463	6.4	0	Golgi apparatus;Secreted	NA	May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.	Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.;N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.;Phosphorylated by FAM20C in the extracellular medium.	Belongs to the ITIH family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	10
+NX_P19827	Inter-alpha-trypsin inhibitor heavy chain H1	911	101389	6.31	0	Cytoplasmic vesicle;Secreted	NA	Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.;May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.	The S-linked glycan is composed of two 6-carbon sugars, possibly Glc or Gal.;Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.	Belongs to the ITIH family.	NA	PE1	3
+NX_P19835	Bile salt-activated lipase	753	79322	5.13	0	Secreted	Maturity-onset diabetes of the young 8 with exocrine dysfunction	Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499).	N- and O-glycosylated.	Belongs to the type-B carboxylesterase/lipase family.	Steroid biosynthesis;Glycerolipid metabolism;Metabolic pathways;Pancreatic secretion;Fat digestion and absorption;Digestion of dietary lipid	PE1	9
+NX_P19838	Nuclear factor NF-kappa-B p105 subunit	968	105356	5.2	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	Immunodeficiency, common variable, 12	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. P50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.	The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation.;S-nitrosylation of Cys-61 affects DNA binding.;While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p50 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.;Polyubiquitination seems to allow p105 processing.;Phosphorylation at 'Ser-903' and 'Ser-907' primes p105 for proteolytic processing in response to TNF-alpha stimulation. Phosphorylation at 'Ser-927' and 'Ser-932' are required for BTRC/BTRCP-mediated proteolysis.;NFKB1 is phosphorylated by RPS6KA1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	MAPK signaling pathway;Chemokine signaling pathway;Apoptosis;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Neurotrophin signaling pathway;Adipocytokine signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Salmonella infection;Pertussis;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Tuberculosis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Herpes simplex infection;Pathways in cancer;Pancreatic cancer;Prostate cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Activation of NF-kappaB in B cells;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;PKMTs methylate histone lysines;Downstream TCR signaling;The NLRP3 inflammasome;Senescence-Associated Secretory Phenotype (SASP);RIP-mediated NFkB activation via ZBP1;DEx/H-box helicases activate type I IFN and inflammatory cytokines production;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;Transcriptional regulation of white adipocyte differentiation;CLEC7A/inflammasome pathway;CD209 (DC-SIGN) signaling;IkBA variant leads to EDA-ID;Regulated proteolysis of p75NTR;NF-kB is activated and signals survival;Interleukin-1 processing;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neutrophil degranulation;Interleukin-1 signaling	PE1	4
+NX_P19875	C-X-C motif chemokine 2	107	11389	10.57	0	Secreted	NA	Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.	The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;NOD-like receptor signaling pathway;Salmonella infection;Legionellosis;G alpha (i) signalling events;Chemokine receptors bind chemokines;Interleukin-10 signaling	PE1	4
+NX_P19876	C-X-C motif chemokine 3	107	11342	10.4	0	Secreted	NA	Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.	N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Salmonella infection;Legionellosis;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	4
+NX_P19878	Neutrophil cytosol factor 2	526	59762	5.88	0	Cytoplasm;Cytosol;Nucleolus	Granulomatous disease, chronic, cytochrome-b-positive 2, autosomal recessive	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).	NA	Belongs to the NCF2/NOXA1 family.	Phagosome;Osteoclast differentiation;Leukocyte transendothelial migration;Leishmaniasis;Detoxification of Reactive Oxygen Species;VEGFA-VEGFR2 Pathway;ROS and RNS production in phagocytes;Cross-presentation of particulate exogenous antigens (phagosomes);RHO GTPases Activate NADPH Oxidases	PE1	1
+NX_P19883	Follistatin	344	38007	5.53	0	Secreted	NA	Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).	NA	NA	TGF-beta signaling pathway;Antagonism of Activin by Follistatin	PE1	5
+NX_P19957	Elafin	117	12270	9.14	0	Secreted;Cell membrane	NA	Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).	NA	NA	Antimicrobial peptides;Formation of the cornified envelope	PE1	20
+NX_P19961	Alpha-amylase 2B	511	57710	6.64	0	Secreted	NA	NA	NA	Belongs to the glycosyl hydrolase 13 family.	Starch and sucrose metabolism;Metabolic pathways;Pancreatic secretion;Carbohydrate digestion and absorption;Digestion of dietary carbohydrate	PE1	1
+NX_P19971	Thymidine phosphorylase	482	49955	5.36	0	Golgi apparatus;Nucleus	Mitochondrial DNA depletion syndrome 1, MNGIE type	May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.;Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	NA	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.	Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.;Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Bladder cancer;Pyrimidine catabolism;Pyrimidine salvage	PE1	22
+NX_P20020	Plasma membrane calcium-transporting ATPase 1	1220	134685	5.65	10	Basolateral cell membrane;Synapse;Cell membrane	NA	Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511).	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.	Calcium signaling pathway;Endocrine and other factor-regulated calcium reabsorption;Salivary secretion;Pancreatic secretion;Mineral absorption;Ion transport by P-type ATPases;Reduction of cytosolic Ca++ levels;Ion homeostasis	PE1	12
+NX_P20023	Complement receptor type 2	1033	112916	7.74	1	Cell membrane	Immunodeficiency, common variable, 7;Systemic lupus erythematosus 9	(Microbial infection) Acts as a receptor for Epstein-Barr virus.;Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047).	NA	Belongs to the receptors of complement activation (RCA) family.	Complement and coagulation cascades;Hematopoietic cell lineage;B cell receptor signaling pathway;Regulation of Complement cascade	PE1	1
+NX_P20036	HLA class II histocompatibility antigen, DP alpha 1 chain	260	29381	5.07	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;Lysosome membrane;trans-Golgi network membrane;Cytoplasmic vesicle	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	NA	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P20039	HLA class II histocompatibility antigen, DRB1-11 beta chain	266	30160	6.71	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;trans-Golgi network membrane;Lysosome membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P20042	Eukaryotic translation initiation factor 2 subunit 2	333	38388	5.6	0	Endoplasmic reticulum;Cytoplasm;Nucleolus	NA	EIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.	NA	Belongs to the eIF-2-beta/eIF-5 family.	RNA transport;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP;ABC-family proteins mediated transport;PERK regulates gene expression	PE1	20
+NX_P20061	Transcobalamin-1	433	48207	4.96	0	Secreted	NA	Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.	Contains about 30% carbohydrates.	Belongs to the eukaryotic cobalamin transport proteins family.	Cobalamin (Cbl, vitamin B12) transport and metabolism;Neutrophil degranulation	PE1	11
+NX_P20062	Transcobalamin-2	427	47535	6.52	0	Cytosol;Secreted	Transcobalamin II deficiency	Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.	NA	Belongs to the eukaryotic cobalamin transport proteins family.	Vitamin digestion and absorption;Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective CD320 causes methylmalonic aciduria;Defective TCN2 causes hereditary megaloblastic anemia	PE1	22
+NX_P20073	Annexin A7	488	52739	5.52	0	Nucleoplasm;Cytosol	NA	Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.	NA	Belongs to the annexin family.	NA	PE1	10
+NX_P20132	L-serine dehydratase/L-threonine deaminase	328	34625	8.15	0	Cytoplasm;Cytosol;Mitochondrion	NA	NA	NA	Belongs to the serine/threonine dehydratase family.	Carbohydrate biosynthesis; gluconeogenesis.;Glycine, serine and threonine metabolism;Cysteine and methionine metabolism;Metabolic pathways;Threonine catabolism	PE1	12
+NX_P20138	Myeloid cell surface antigen CD33	364	39825	8.68	1	Nucleoplasm;Peroxisome;Cell membrane	NA	Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).	Glycosylated. Glycosylation at Asn-100 is critical for regulating ligand recognition.;Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. LCK phosphorylates Tyr-340 efficiently and Tyr-358 to a lesser extent.	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Hematopoietic cell lineage;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Neutrophil degranulation	PE1	19
+NX_P20142	Gastricsin	388	42426	4.36	0	Nucleoplasm;Secreted	NA	Hydrolyzes a variety of proteins.	NA	Belongs to the peptidase A1 family.	NA	PE1	6
+NX_P20151	Kallikrein-2	261	28671	6.44	0	NA	NA	Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.	NA	Belongs to the peptidase S1 family. Kallikrein subfamily.	Endocrine and other factor-regulated calcium reabsorption;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Activation of Matrix Metalloproteinases	PE1	19
+NX_P20155	Serine protease inhibitor Kazal-type 2	84	9291	9.3	0	Secreted;Acrosome	Spermatogenic failure 29	As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin.	NA	NA	NA	PE1	4
+NX_P20160	Azurocidin	251	26886	9.75	0	Cytoplasmic vesicle;Cytoplasmic granule membrane	NA	This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.	Cleavage of the N-terminal propeptide which is composed of 7 amino acids occurs in two steps. The initial cleavage of 5 amino acids is followed by the cleavage of a dipeptide to produce the mature form.	Belongs to the peptidase S1 family. Elastase subfamily.	Neutrophil degranulation	PE1	19
+NX_P20226	TATA-box-binding protein	339	37698	9.8	0	Nucleoplasm;Nucleus	Spinocerebellar ataxia 17	General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.	NA	Belongs to the TBP family.	Basal transcription factors;Huntington's disease;HTLV-I infection;Herpes simplex infection;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;SIRT1 negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;RNA polymerase II transcribes snRNA genes;Regulation of TP53 Activity through Phosphorylation;Estrogen-dependent gene expression	PE1	6
+NX_P20231	Tryptase beta-2	275	30515	6.62	0	Secreted	NA	Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.	NA	Belongs to the peptidase S1 family. Tryptase subfamily.	NA	PE1	16
+NX_P20248	Cyclin-A2	432	48551	6.1	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.	Belongs to the cyclin family. Cyclin AB subfamily.	Cell cycle;Progesterone-mediated oocyte maturation;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SCF(Skp2)-mediated degradation of p27/p21;G0 and Early G1;Cyclin A/B1/B2 associated events during G2/M transition;Regulation of APC/C activators between G1/S and early anaphase;Cyclin A:Cdk2-associated events at S phase entry;Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes;G2 Phase;p53-Dependent G1 DNA Damage Response;Processing of DNA double-strand break ends;Regulation of TP53 Activity through Phosphorylation;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Degradation;Ub-specific processing proteases;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	PE1	4
+NX_P20264	POU domain, class 3, transcription factor 3	500	50327	7.51	0	Nucleoplasm;Nucleus	NA	Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity).	NA	Belongs to the POU transcription factor family. Class-3 subfamily.	NA	PE1	2
+NX_P20265	POU domain, class 3, transcription factor 2	443	46893	7.51	0	Nucleoplasm;Nucleus	NA	Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity).	NA	Belongs to the POU transcription factor family. Class-3 subfamily.	NA	PE1	6
+NX_P20273	B-cell receptor CD22	847	95348	6.21	1	Cell membrane	NA	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.	Phosphorylated on tyrosine residues by LYN.;Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Cell adhesion molecules (CAMs);Hematopoietic cell lineage;B cell receptor signaling pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CD22 mediated BCR regulation	PE1	19
+NX_P20290	Transcription factor BTF3	206	22168	9.41	0	Cytoplasm;Cytosol;Nucleus	NA	When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	NA	Belongs to the NAC-beta family.	NA	PE1	5
+NX_P20292	Arachidonate 5-lipoxygenase-activating protein	161	18157	8.58	4	Endoplasmic reticulum membrane;Nucleus membrane	Ischemic stroke	Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.	NA	Belongs to the MAPEG family.	Synthesis of Leukotrienes (LT) and Eoxins (EX);Synthesis of Lipoxins (LX);Synthesis of 5-eicosatetraenoic acids	PE1	13
+NX_P20309	Muscarinic acetylcholine receptor M3	590	66128	9.33	7	Basolateral cell membrane;Cell membrane;Postsynaptic cell membrane	Prune belly syndrome	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.	CHRM3 is phosphorylated by GRK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Cholinergic synapse;Regulation of actin cytoskeleton;Salivary secretion;Gastric acid secretion;Pancreatic secretion;G alpha (q) signalling events;Muscarinic acetylcholine receptors;Acetylcholine regulates insulin secretion	PE1	1
+NX_P20333	Tumor necrosis factor receptor superfamily member 1B	461	48291	5.88	1	Secreted;Cell membrane	NA	Blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.;Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha.	Phosphorylated; mainly on serine residues and with a very low level on threonine residues.;A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.	NA	Cytokine-cytokine receptor interaction;Adipocytokine signaling pathway;Amyotrophic lateral sclerosis (ALS);TNFR2 non-canonical NF-kB pathway;TNFs bind their physiological receptors;Neutrophil degranulation;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling	PE1	1
+NX_P20336	Ras-related protein Rab-3A	220	24984	4.85	0	Cell membrane;Nucleoplasm;Centrosome;Lysosome;Cytosol;Secretory vesicle	NA	Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141). Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity).	Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.	Belongs to the small GTPase superfamily. Rab family.	Synaptic vesicle cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	19
+NX_P20337	Ras-related protein Rab-3B	219	24758	4.85	0	Golgi apparatus;Cell junction;Cell membrane	NA	Protein transport. Probably involved in vesicular traffic (By similarity).	Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2.	Belongs to the small GTPase superfamily. Rab family.	Tight junction;RAB geranylgeranylation	PE1	1
+NX_P20338	Ras-related protein Rab-4A	218	24390	5.82	0	Membrane;Cytoplasm;Early endosome membrane;Recycling endosome membrane	NA	Protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling.	Phosphorylated by CDK1 kinase during mitosis.	Belongs to the small GTPase superfamily. Rab family.	Endocytosis;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Synthesis of PIPs at the plasma membrane;MET receptor recycling;TBC/RABGAPs;RAB geranylgeranylation	PE1	1
+NX_P20339	Ras-related protein Rab-5A	215	23659	8.32	0	Endosome membrane;Cell membrane;Phagosome membrane;Membrane;Early endosome membrane;Melanosome;Ruffle;Cytoplasmic vesicle;Cytosol	NA	Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).	Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.	Belongs to the small GTPase superfamily. Rab family.	Endocytosis;Phagosome;Vasopressin-regulated water reabsorption;Amyotrophic lateral sclerosis (ALS);Amoebiasis;Tuberculosis;Factors involved in megakaryocyte development and platelet production;Synthesis of PIPs at the plasma membrane;Clathrin-mediated endocytosis;RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs;RAB geranylgeranylation	PE1	3
+NX_P20340	Ras-related protein Rab-6A	208	23593	5.42	0	Golgi apparatus membrane	NA	Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed:25962623).	Prenylated.	Belongs to the small GTPase superfamily. Rab family.	Pre-NOTCH Processing in Golgi;COPI-independent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs;RAB geranylgeranylation	PE1	11
+NX_P20366	Protachykinin-1	129	15003	8.89	0	Secreted	NA	Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.	The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).	Belongs to the tachykinin family.	G alpha (q) signalling events;Tachykinin receptors bind tachykinins	PE1	7
+NX_P20382	Pro-MCH	165	18679	6.74	0	Secreted	NA	MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.	Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6.	Belongs to the melanin-concentrating hormone family.	G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	12
+NX_P20393	Nuclear receptor subfamily 1 group D member 1	614	66805	8.83	0	Cytoplasm;Dendritic spine;Dendrite;Nucleus	NA	Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity).	Ubiquitinated, leading to its proteasomal degradation (PubMed:16484495, PubMed:23398316, PubMed:20534529). Ubiquitinated by SIAH2; leading to its proteasomal degradation (PubMed:26392558). Ubiquitinated by the SCF(FBXW7) complex when phosphorylated by CDK1 leading to its proteasomal degradation (By similarity). Rapidly ubiquitinated in response to inflammatory triggers and sumoylation is a prerequisite to its ubiquitination (By similarity).;Sumoylated by UBE2I, desumoylated by SENP1, and sumoylation is a prerequisite to its ubiquitination.;Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.;Phosphorylated by CSNK1E; phosphorylation enhances its cytoplasmic localization.	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Circadian rhythm - mammal;PPARA activates gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Nuclear Receptor transcription pathway;NR1D1 (REV-ERBA) represses gene expression	PE1	17
+NX_P20396	Pro-thyrotropin-releasing hormone	242	27404	5.34	0	Secreted	NA	As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.	NA	Belongs to the TRH family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	3
+NX_P20472	Parvalbumin alpha	110	12059	4.98	0	Nucleoplasm;Cell junction;Nucleolus	NA	In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.	NA	Belongs to the parvalbumin family.	Transcriptional Regulation by MECP2	PE1	22
+NX_P20585	DNA mismatch repair protein Msh3	1137	127412	8.2	0	Nucleus	Endometrial cancer;Familial adenomatous polyposis 4	Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.	NA	Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.	Mismatch repair;Pathways in cancer;Colorectal cancer;Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Defective Mismatch Repair Associated With MSH2;Defective Mismatch Repair Associated With MSH3	PE1	5
+NX_P20591	Interferon-induced GTP-binding protein Mx1	662	75520	5.6	0	Cytoplasm;Endoplasmic reticulum membrane;Nucleus membrane;Cytosol;Perinuclear region;Nucleus	NA	Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.	ISGylated.	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Measles;Influenza A;ISG15 antiviral mechanism;Interferon alpha/beta signaling	PE1	21
+NX_P20592	Interferon-induced GTP-binding protein Mx2	715	82089	8.91	0	Cytoplasm;Nucleus;Nuclear pore complex	NA	Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	ISG15 antiviral mechanism;Interferon alpha/beta signaling	PE1	21
+NX_P20594	Atrial natriuretic peptide receptor 2	1047	117022	6.41	1	Cell membrane	Short stature with non-specific skeletal abnormalities;Acromesomelic dysplasia, Maroteaux type;Epiphyseal chondrodysplasia, Miura type	Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.	Glycosylated.;Phosphorylated (PubMed:26980729). Phosphorylation of the protein kinase-like domain is required for full activation by CNP (By similarity).	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Vascular smooth muscle contraction;Physiological factors	PE1	9
+NX_P20618	Proteasome subunit beta type-1	241	26489	8.27	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).	NA	Belongs to the peptidase T1B family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	6
+NX_P20645	Cation-dependent mannose-6-phosphate receptor	277	30993	5.57	1	Lysosome membrane	NA	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.	NA	NA	Lysosome;Phagosome;Lysosome Vesicle Biogenesis;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	12
+NX_P20648	Potassium-transporting ATPase alpha chain 1	1035	114119	5.58	10	Cell membrane	NA	Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.	Oxidative phosphorylation;Collecting duct acid secretion;Gastric acid secretion;Ion transport by P-type ATPases	PE1	19
+NX_P20671	Histone H2A type 1-D	130	14107	10.9	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).;Deiminated on Arg-4 in granulocytes upon calcium entry.;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.	Belongs to the histone H2A family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;RMTs methylate histone arginines;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_P20674	Cytochrome c oxidase subunit 5A, mitochondrial	150	16762	6.3	0	Mitochondrion inner membrane	NA	This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase subunit 5A family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	15
+NX_P20700	Lamin-B1	586	66408	5.11	0	Nucleus inner membrane;Nucleus membrane;Nucleus	Leukodystrophy, demyelinating, autosomal dominant, adult-onset	Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.	B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.;LMNB1 is phosphorylated by MAPK3;LMNB1 is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the intermediate filament family.	Formation of Senescence-Associated Heterochromatin Foci (SAHF);Meiotic synapsis;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina;Breakdown of the nuclear lamina;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Nuclear Envelope Breakdown	PE1	5
+NX_P20701	Integrin alpha-L	1170	128770	5.4	1	Cell membrane	NA	Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).	In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.	Belongs to the integrin alpha chain family.	Cell adhesion molecules (CAMs);Natural killer cell mediated cytotoxicity;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Malaria;Staphylococcus aureus infection;HTLV-I infection;Rheumatoid arthritis;Viral myocarditis;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions;Cell surface interactions at the vascular wall;Neutrophil degranulation;RUNX3 Regulates Immune Response and Cell Migration	PE1	16
+NX_P20702	Integrin alpha-X	1163	127829	6.19	1	Membrane	NA	Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.	NA	Belongs to the integrin alpha chain family.	Regulation of actin cytoskeleton;Tuberculosis;Integrin cell surface interactions;Cell surface interactions at the vascular wall;ECM proteoglycans;Neutrophil degranulation;Interleukin-4 and Interleukin-13 signaling	PE1	16
+NX_P20711	Aromatic-L-amino-acid decarboxylase	480	53926	6.77	0	Cytoskeleton	Aromatic L-amino-acid decarboxylase deficiency	Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.	NA	Belongs to the group II decarboxylase family.	Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;Tryptophan metabolism;Metabolic pathways;Serotonin and melatonin biosynthesis;Catecholamine biosynthesis	PE1	7
+NX_P20718	Granzyme H	246	27315	9.83	0	Cytoplasmic granule	NA	Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.	NA	Belongs to the peptidase S1 family. Granzyme subfamily.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Metabolism of Angiotensinogen to Angiotensins	PE1	14
+NX_P20719	Homeobox protein Hox-A5	270	29345	9.32	0	Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.	NA	Belongs to the Antp homeobox family.	NA	PE1	7
+NX_P20742	Pregnancy zone protein	1482	163863	5.97	0	Secreted	NA	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.	NA	Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.	NA	PE1	12
+NX_P20749	B-cell lymphoma 3 protein	454	47584	8.72	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Nucleus;Perinuclear region;Midbody	NA	Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).	Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity).;Activated by phosphorylation.	NA	NA	PE1	19
+NX_P20774	Mimecan	298	33922	5.46	0	Endoplasmic reticulum;Extracellular matrix	NA	Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.	N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.	Keratan sulfate biosynthesis;Defective CHST6 causes MCDC1;Keratan sulfate degradation;Defective B4GALT1 causes B4GALT1-CDG (CDG-2d);Defective ST3GAL3 causes MCT12 and EIEE15	PE1	9
+NX_P20783	Neurotrophin-3	257	29355	9.46	0	Cytoplasmic vesicle;Secreted	NA	Seems to promote the survival of visceral and proprioceptive sensory neurons.	NA	Belongs to the NGF-beta family.	MAPK signaling pathway;Neurotrophin signaling pathway;Activated NTRK3 signals through RAS;Activated NTRK3 signals through PI3K;Signaling by NTRK3 (TRKC);NTF3 activates NTRK2 (TRKB) signaling;NTF3 activates NTRK3 signaling;Activated NTRK3 signals through PLCG1	PE1	12
+NX_P20794	Serine/threonine-protein kinase MAK	623	70581	9.67	0	Photoreceptor inner segment;Photoreceptor outer segment;Centrosome;Nucleus;Spindle;Midbody	Retinitis pigmentosa 62	Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.	Autophosphorylated. Phosphorylated on serine and threonine residues.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	6
+NX_P20800	Endothelin-2	178	19960	10.3	0	Cytosol;Secreted	NA	Endothelins are endothelium-derived vasoconstrictor peptides.	NA	Belongs to the endothelin/sarafotoxin family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	1
+NX_P20807	Calpain-3	821	94254	5.81	0	Cytoplasm	Muscular dystrophy, limb-girdle, autosomal dominant 4;Muscular dystrophy, limb-girdle, autosomal recessive 1	Calcium-regulated non-lysosomal thiol-protease.	NA	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	15
+NX_P20809	Interleukin-11	199	21429	10.64	0	Secreted	NA	Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.	NA	Belongs to the IL-6 superfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Rheumatoid arthritis;IL-6-type cytokine receptor ligand interactions	PE1	19
+NX_P20810	Calpastatin	708	76573	4.98	0	Endoplasmic reticulum;Cytoplasm;Cytosol	Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads	Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.	The N-terminus is blocked.	Belongs to the protease inhibitor I27 (calpastatin) family.	Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	PE1	5
+NX_P20813	Cytochrome P450 2B6	491	56278	8.43	0	Microsome membrane;Endoplasmic reticulum membrane;Nucleus membrane;Nucleoplasm;Cytosol	NA	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.	Phosphorylation is accompanied by a decrease in enzyme activity.	Belongs to the cytochrome P450 family.	Arachidonic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Xenobiotics;Fatty acids;CYP2E1 reactions	PE1	19
+NX_P20815	Cytochrome P450 3A5	502	57109	8.86	0	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:2732228, PubMed:10681376, PubMed:11093772, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:2732228, PubMed:10681376, PubMed:11093772). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228).	NA	Belongs to the cytochrome P450 family.	Steroid hormone biosynthesis.;Cofactor metabolism; retinol metabolism.;Steroid hormone biosynthesis;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Xenobiotics;Aflatoxin activation and detoxification	PE1	7
+NX_P20823	Hepatocyte nuclear factor 1-alpha	631	67356	5.82	0	Nucleoplasm;Nucleus	Diabetes mellitus, insulin-dependent, 20;Maturity-onset diabetes of the young 3;Hepatic adenomas familial	Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:12453420, PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity).	NA	Belongs to the HNF1 homeobox family.	Maturity onset diabetes of the young;Regulation of gene expression in beta cells	PE1	12
+NX_P20827	Ephrin-A1	205	23787	6.34	0	Secreted;Cell membrane	NA	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.	N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization.;Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.	Belongs to the ephrin family.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	1
+NX_P20839	Inosine-5'-monophosphate dehydrogenase 1	514	55406	6.43	0	Cytoplasm;Nucleus	Leber congenital amaurosis 11;Retinitis pigmentosa 10	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	NA	Belongs to the IMPDH/GMPR family.	Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.;Purine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Purine ribonucleoside monophosphate biosynthesis;Neutrophil degranulation	PE1	7
+NX_P20848	Putative alpha-1-antitrypsin-related protein	420	47891	7.73	0	Endoplasmic reticulum	NA	Putative serine protease inhibitor.	Glycosylated.	Belongs to the serpin family.	NA	PE1	14
+NX_P20849	Collagen alpha-1(IX) chain	921	91869	8.94	0	Extracellular matrix	Stickler syndrome 4;Multiple epiphyseal dysplasia 6	Structural component of hyaline cartilage and vitreous of the eye.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.;Covalently linked to the telopeptides of type II collagen by lysine-derived cross-links.	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.	Protein digestion and absorption;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	6
+NX_P20851	C4b-binding protein beta chain	252	28357	5.05	0	Secreted	NA	Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.	NA	NA	Complement and coagulation cascades;Pertussis;Regulation of Complement cascade	PE1	1
+NX_P20853	Cytochrome P450 2A7	494	56425	7.69	0	Microsome membrane;Endoplasmic reticulum membrane	NA	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	NA	Belongs to the cytochrome P450 family.	Caffeine metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Xenobiotics;Fatty acids;CYP2E1 reactions	PE1	19
+NX_P20908	Collagen alpha-1(V) chain	1838	183560	4.94	0	Cytoplasmic vesicle;Extracellular matrix	Ehlers-Danlos syndrome, classic type, 1	Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.;Sulfated on 40% of tyrosines.	Belongs to the fibrillar collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Syndecan interactions;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Non-integrin membrane-ECM interactions;Extracellular matrix organization;MET activates PTK2 signaling;Collagen chain trimerization	PE1	9
+NX_P20916	Myelin-associated glycoprotein	626	69069	4.97	1	Membrane raft;Cell membrane	Spastic paraplegia 75, autosomal recessive	Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity).	N-glycosylated.;Phosphorylated on tyrosine residues.;Ubiquitinated, leading to proteasomal degradation.	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Cell adhesion molecules (CAMs);Axonal growth inhibition (RHOA activation);Basigin interactions	PE1	19
+NX_P20929	Nebulin	6669	772914	9.11	0	Cytoskeleton;Sarcomere	Nemaline myopathy 2	This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin.	NA	NA	Striated Muscle Contraction	PE1	2
+NX_P20930	Filaggrin	4061	435170	9.24	0	Cytosol;Cytoplasmic granule	Ichthyosis vulgaris;Dermatitis atopic 2	Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.	Undergoes deimination of some arginine residues (citrullination).;Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate.	Belongs to the S100-fused protein family.	Formation of the cornified envelope	PE1	1
+NX_P20933	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	346	37208	5.86	0	Lysosome	Aspartylglucosaminuria	Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.	Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.;N-glycosylated.	Belongs to the Ntn-hydrolase family.	Other glycan degradation;Lysosome;Neutrophil degranulation	PE1	4
+NX_P20936	Ras GTPase-activating protein 1	1047	116403	6.11	0	Cytoplasm	Capillary malformation-arteriovenous malformation 1	Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.	Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity, whereas phosphorylation by LCK does not display any effect on stimulation activity.;The N-terminus is blocked.;RASA1 is phosphorylated by INSRR (Phosphotyrosine:PTM-0255);RASA1 is phosphorylated by SRC	NA	MAPK signaling pathway;Axon guidance;Regulation of RAS by GAPs;EPHB-mediated forward signaling;VEGFR2 mediated cell proliferation;Downstream signal transduction;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;Signaling by RAS mutants	PE1	5
+NX_P20941	Phosducin	246	28246	5.08	0	Photoreceptor inner segment;Photoreceptor outer segment;Cytosol;Nucleus	NA	May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.	Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.	Belongs to the phosducin family.	Olfactory transduction	PE1	1
+NX_P20962	Parathymosin	102	11530	4.14	0	Nucleoplasm;Nucleolus;Nucleus	NA	Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.	NA	Belongs to the pro/parathymosin family.	NA	PE1	12
+NX_P20963	T-cell surface glycoprotein CD3 zeta chain	164	18696	9.28	1	Membrane	Immunodeficiency 25	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity).	Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.;CD247 is phosphorylated by LCK	Belongs to the CD3Z/FCER1G family.	Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;Chagas disease (American trypanosomiasis);Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling;Role of phospholipids in phagocytosis;FCGR activation;Nef and signal transduction	PE1	1
+NX_P21108	Ribose-phosphate pyrophosphokinase 3	318	34839	5.92	0	NA	NA	Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.	NA	Belongs to the ribose-phosphate pyrophosphokinase family.	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.;Pentose phosphate pathway;Purine metabolism;Metabolic pathways;5-Phosphoribose 1-diphosphate biosynthesis	PE1	7
+NX_P21127	Cyclin-dependent kinase 11B	795	92620	5.42	0	Cytoplasm;Nucleus	NA	Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner.;May act as a negative regulator of normal cell cycle progression.	During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.;Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. P110C can be autophosphorylated.;CDK11B is phosphorylated by CDK7	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Recruitment of mitotic centrosome proteins and complexes	PE1	1
+NX_P21128	Poly(U)-specific endoribonuclease	410	46872	5.26	0	Secreted	NA	Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini.	It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.	Belongs to the ENDOU family.	NA	PE1	12
+NX_P21145	Myelin and lymphocyte protein	153	16714	5.55	4	Membrane;Golgi apparatus;Centrosome	NA	Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.	Lipoprotein.	Belongs to the MAL family.	NA	PE1	2
+NX_P21217	Galactoside 3(4)-L-fucosyltransferase	361	42117	9.16	1	Golgi stack membrane	NA	May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.	NA	Belongs to the glycosyltransferase 10 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Reactions specific to the complex N-glycan synthesis pathway;Lewis blood group biosynthesis	PE1	19
+NX_P21246	Pleiotrophin	168	18942	9.66	0	Endoplasmic reticulum;Golgi apparatus;Secreted	NA	Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:16814777, PubMed:11278720, PubMed:19141530). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (PubMed:26896299, PubMed:27445335). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:1733956, PubMed:1768439, PubMed:11278720, PubMed:19141530, PubMed:27445335, PubMed:30667096, PubMed:19442624). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:17681947, PubMed:27445335, PubMed:30667096, PubMed:16814777, PubMed:10706604). Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335, PubMed:30667096). Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (PubMed:19141530). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (By similarity). Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (PubMed:11278720). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway (By similarity). Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration (By similarity). In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity).	Phosphorylated by NEK6.;PTN is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the pleiotrophin family.	NA	PE1	7
+NX_P21266	Glutathione S-transferase Mu 3	225	26560	5.37	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.	The N-terminus is blocked.	Belongs to the GST superfamily. Mu family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation	PE1	1
+NX_P21281	V-type proton ATPase subunit B, brain isoform	511	56501	5.57	0	Cytoplasmic vesicle;Endomembrane system;Melanosome	Deafness, congenital, with onychodystrophy, autosomal dominant;Zimmermann-Laband syndrome 2	Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	NA	Belongs to the ATPase alpha/beta chains family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	8
+NX_P21283	V-type proton ATPase subunit C 1	382	43942	7.02	0	Nucleoplasm;Cytosol	NA	Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	NA	Belongs to the V-ATPase C subunit family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	8
+NX_P21291	Cysteine and glycine-rich protein 1	193	20567	8.9	0	Nucleus	NA	Could play a role in neuronal development.	NA	NA	MTF1 activates gene expression	PE1	1
+NX_P21333	Filamin-A	2647	280739	5.7	0	Cytosol;Cell cortex;Cell membrane;Cytoskeleton	Cardiac valvular dysplasia X-linked;Otopalatodigital syndrome 1;Otopalatodigital syndrome 2;Melnick-Needles syndrome;FG syndrome 2;Terminal osseous dysplasia;Periventricular nodular heterotopia 1;Congenital short bowel syndrome, X-linked;Frontometaphyseal dysplasia 1;Intestinal pseudoobstruction, neuronal, chronic idiopathic, X-linked	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity).	Phosphorylation extent changes in response to cell activation.;Phosphorylation at Ser-2152 is negatively regulated by the autoinhibited conformation of filamin repeats 19-21. Ligand binding induces a conformational switch triggering phosphorylation at Ser-2152 by PKA.;Polyubiquitination in the CH1 domain by a SCF-like complex containing ASB2 leads to proteasomal degradation. Prior dissociation from actin may be required to expose the target lysines (PubMed:24052262). Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome (PubMed:26766444).	Belongs to the filamin family.	MAPK signaling pathway;Focal adhesion;Salmonella infection;Platelet degranulation;RHO GTPases activate PAKs;GP1b-IX-V activation signalling;Cell-extracellular matrix interactions;OAS antiviral response	PE1	X
+NX_P21359	Neurofibromin	2839	319372	7.1	0	Nucleus;Mitochondrion;Nucleolus	Neurofibromatosis 1;Familial spinal neurofibromatosis;Leukemia, juvenile myelomonocytic;Colorectal cancer;Neurofibromatosis-Noonan syndrome;Watson syndrome	Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.	NA	NA	MAPK signaling pathway;Regulation of RAS by GAPs;Signaling by RAS mutants;RAS signaling downstream of NF1 loss-of-function variants	PE1	17
+NX_P21397	Amine oxidase [flavin-containing] A	527	59682	7.94	1	Mitochondrion outer membrane;Cytosol;Mitochondrion	Brunner syndrome	Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.	NA	Belongs to the flavin monoamine oxidase family.	Glycine, serine and threonine metabolism;Arginine and proline metabolism;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;Tryptophan metabolism;Drug metabolism - cytochrome P450;Metabolic pathways;Dopaminergic synapse;Norepinephrine Neurotransmitter Release Cycle;Enzymatic degradation of dopamine by COMT;Enzymatic degradation of Dopamine by monoamine oxidase;Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB;Metabolism of serotonin;Defective MAOA causes Brunner syndrome (BRUNS);Interleukin-4 and Interleukin-13 signaling	PE1	X
+NX_P21399	Cytoplasmic aconitate hydratase	889	98399	6.23	0	Cytoplasm;Cytosol;Mitochondrion	NA	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.;Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.	NA	Belongs to the aconitase/IPM isomerase family.	Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Iron uptake and transport	PE1	9
+NX_P21439	Phosphatidylcholine translocator ABCB4	1286	141523	8.65	12	Clathrin-coated vesicle;Cytoplasm;Cell membrane;Focal adhesion;Nucleoplasm;Apical cell membrane;Membrane raft;Cytoskeleton	Cholestasis, progressive familial intrahepatic, 3;Cholestasis of pregnancy, intrahepatic 3;Gallbladder disease 1	Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571, PubMed:28012258). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity).	Glycosylated (PubMed:17523162, PubMed:24723470, PubMed:21820390).;Phosphorylated (PubMed:24723470). Phosphorylation on Thr-34 is required for PC efflux activity. Phosphorylation occurs on serine and threonine residues in a protein kinase A- or C-dependent manner (PubMed:24723470). May be phosphorylated on Thr-44 and Ser-49 (PubMed:24723470).	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.	ABC transporters;Bile secretion;PPARA activates gene expression;ABC-family proteins mediated transport;Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1	PE1	7
+NX_P21452	Substance-K receptor	398	44442	8.86	7	Cell membrane	NA	This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Tachykinin receptors bind tachykinins	PE1	10
+NX_P21453	Sphingosine 1-phosphate receptor 1	382	42811	9.59	7	Cytoplasmic vesicle;Endosome;Membrane raft;Cell membrane	NA	G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.	S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Lysosphingolipid and LPA receptors;Interleukin-4 and Interleukin-13 signaling	PE1	1
+NX_P21462	fMet-Leu-Phe receptor	350	38446	9.23	7	Golgi apparatus;Nucleoplasm;Nucleolus;Cell membrane	NA	High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685).	Phosphorylated; which is necessary for desensitization.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Staphylococcus aureus infection;G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands;Neutrophil degranulation;Interleukin-10 signaling	PE1	19
+NX_P21506	Zinc finger protein 10	573	66455	8.68	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	12
+NX_P21549	Serine--pyruvate aminotransferase	392	43010	8.61	0	Cytoplasmic vesicle;Peroxisome;Mitochondrion	Hyperoxaluria primary 1	NA	NA	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.	Alanine, aspartate and glutamate metabolism;Glycine, serine and threonine metabolism;Metabolic pathways;Peroxisome;Glyoxylate metabolism and glycine degradation;Peroxisomal protein import	PE1	2
+NX_P21554	Cannabinoid receptor 1	472	52858	8.47	7	Mitochondrion outer membrane;Cell membrane;Presynapse;Axon;Membrane raft;Cytoskeleton	Obesity	Binds both 2-AG and anandamide.;Only binds 2-AG with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 3 in assays measuring GTP binding to membranes.;G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (PubMed:17895407). In cerebral vascular smooth muscle cells, cannabinoid-induced inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (By similarity). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism (By similarity). In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (By similarity). In response to cannabinoid anandamide, elicits a proinflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712).;Only binds 2-AG with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 2 in assays measuring GTP binding to membranes.	Palmitoylation at Cys-415 is important for recruitment at plasma membrane and lipid rafts and association with G protein alpha subunits.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Class A/1 (Rhodopsin-like receptors)	PE1	6
+NX_P21579	Synaptotagmin-1	422	47573	8.26	1	Cytoplasm;Synaptic vesicle membrane;Secretory vesicle membrane;Chromaffin granule membrane	Baker-Gordon syndrome	Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).	Glycosylated.	Belongs to the synaptotagmin family.	Synaptic vesicle cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Toxicity of botulinum toxin type G (BoNT/G);Toxicity of botulinum toxin type B (BoNT/B);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Neurexins and neuroligins	PE1	12
+NX_P21580	Tumor necrosis factor alpha-induced protein 3	790	89614	8.61	0	Cytoplasmic vesicle;Cytoplasm;Nucleus;Lysosome	Autoinflammatory syndrome, familial, Behcet-like	Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.	Proteolytically cleaved by MALT1 upon TCR stimulation; disrupts NF-kappa-B inhibitory function and results in increased IL-2 production. It is proposed that only a fraction of TNFAIP3 colocalized with TCR and CBM complex is cleaved, leaving the main TNFAIP3 pool intact.	Belongs to the peptidase C64 family.	NOD-like receptor signaling pathway;Measles;NOD1/2 Signaling Pathway;Negative regulators of DDX58/IFIH1 signaling;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ovarian tumor domain proteases	PE1	6
+NX_P21583	Kit ligand	273	30899	5.86	1	Cytoplasm;Cell membrane;Secreted;Lamellipodium;Filopodium;Cytoplasmic vesicle;Cytoskeleton	Hyperpigmentation with or without hypopigmentation, familial progressive;Deafness, congenital, unilateral or asymmetric	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.	A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain.;A soluble form exists as a cleavage product of the extracellular domain.;Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97.	Belongs to the SCF family.	Cytokine-cytokine receptor interaction;Hematopoietic cell lineage;Melanogenesis;Pathways in cancer;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Signaling by SCF-KIT;Regulation of KIT signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	12
+NX_P21589	5'-nucleotidase	574	63368	6.58	0	Nucleoplasm;Cytosol;Cell membrane	Calcification of joints and arteries	Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.	NA	Belongs to the 5'-nucleotidase family.	Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Pyrimidine catabolism;Purine catabolism;Nicotinate metabolism	PE1	6
+NX_P21673	Diamine acetyltransferase 1	171	20024	5.09	0	Cytoplasm;Nucleus	NA	Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.	NA	Belongs to the acetyltransferase family.	Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1.;Arginine and proline metabolism;Metabolic pathways;Interconversion of polyamines	PE1	X
+NX_P21675	Transcription initiation factor TFIID subunit 1	1872	212677	4.97	0	Nucleoplasm;Nucleus	Dystonia 3, torsion, X-linked;Mental retardation, X-linked, syndromic, 33	Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).	Phosphorylated by casein kinase II in vitro.	Belongs to the TAF1 family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation	PE1	X
+NX_P21695	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic	349	37568	5.81	0	Cytoplasm	Hypertriglyceridemia, transient infantile	NA	NA	Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.	Glycerophospholipid metabolism;Synthesis of PA	PE1	12
+NX_P21709	Ephrin type-A receptor 1	976	108127	6.2	1	Cell membrane	NA	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.	Ubiquitinated.;Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;EPHA-mediated growth cone collapse	PE1	7
+NX_P21728	D(1A) dopamine receptor	446	49293	8.64	7	Dendrite;Dendritic spine;Endoplasmic reticulum membrane;Cell membrane	NA	Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.	DRD1 is phosphorylated by GRK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Gap junction;Dopaminergic synapse;G alpha (s) signalling events;Dopamine receptors	PE1	5
+NX_P21730	C5a anaphylatoxin chemotactic receptor 1	350	39336	9.22	7	Cytoplasmic vesicle;Cell membrane	NA	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).	Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand. The key residues involved in this process are Ser-334 and Ser-338.;Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist (PubMed:11342590). Sulfation at Tyr-14 is important for CHIPS binding (PubMed:21706042).	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Staphylococcus aureus infection;G alpha (i) signalling events;Peptide ligand-binding receptors;Regulation of Complement cascade;Neutrophil degranulation	PE1	19
+NX_P21731	Thromboxane A2 receptor	343	37431	10	7	Nucleus speckle;Cell membrane	Bleeding disorder, platelet-type 13	Inhibits adenylyl cyclase.;Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.;Activates adenylyl cyclase.	TBXA2R is phosphorylated by GRK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (q) signalling events;G alpha (12/13) signalling events;Prostanoid ligand receptors;Thromboxane signalling through TP receptor	PE1	19
+NX_P21741	Midkine	143	15585	9.84	0	Cytoplasmic vesicle;Secreted	NA	Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:18469519, PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:24458438, PubMed:15466886, PubMed:12084985, PubMed:10772929). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:12084985, PubMed:10212223). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:10683378, PubMed:24458438, PubMed:22323540, PubMed:12084985, PubMed:15466886, PubMed:10772929). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity).	NA	Belongs to the pleiotrophin family.	NOTCH2 Activation and Transmission of Signal to the Nucleus	PE1	11
+NX_P21754	Zona pellucida sperm-binding protein 3	424	47018	5.49	1	Cytoplasm;Extracellular matrix;Cell membrane	Oocyte maturation defect 3	Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.	Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.;O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.;N-glycosylated.	Belongs to the ZP domain family. ZPC subfamily.	Interaction With Cumulus Cells And The Zona Pellucida	PE1	7
+NX_P21757	Macrophage scavenger receptor types I and II	451	49762	5.61	1	Membrane	Prostate cancer;Barrett esophagus	Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254).;Does not internalize acetylated LDL (PubMed:9548586).	NA	NA	Phagosome;Scavenging by Class A Receptors	PE1	8
+NX_P21781	Fibroblast growth factor 7	194	22509	9.29	0	Nucleoplasm;Secreted;Nucleolus	NA	Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;FGFR2b ligand binding and activation;PI3K Cascade;PIP3 activates AKT signaling;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade, FGFR2;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;Negative regulation of FGFR2 signaling;Signaling by FGFR2 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	15
+NX_P21796	Voltage-dependent anion-selective channel protein 1	283	30773	8.62	19	Mitochondrion outer membrane;Cytoplasmic vesicle;Membrane raft;Cell membrane	NA	Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.;Phosphorylation at Ser-193 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury. Phosphorylation by the AKT-GSK3B axis stabilizes the protein probably by preventing ubiquitin-mediated proteasomal degradation.;VDAC1 is phosphorylated by PRKCE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the eukaryotic mitochondrial porin family.	Calcium signaling pathway;Parkinson's disease;Huntington's disease;Influenza A;HTLV-I infection;Mitochondrial protein import;Pyruvate metabolism;Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases;Mitochondrial calcium ion transport	PE1	5
+NX_P21802	Fibroblast growth factor receptor 2	821	92025	5.61	1	Golgi apparatus;Cell membrane;Cell junction;Secreted;Nucleoplasm;Cytoplasmic vesicle	Jackson-Weiss syndrome;Lacrimo-auriculo-dento-digital syndrome;Pfeiffer syndrome;Saethre-Chotzen syndrome;Bent bone dysplasia syndrome;Crouzon syndrome;Beare-Stevenson cutis gyrata syndrome;Antley-Bixler syndrome, without genital anomalies or disordered steroidogenesis;Apert syndrome;Familial scaphocephaly syndrome	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.	Ubiquitinated. FGFR2 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation. Subject to degradation both in lysosomes and by the proteasome.;Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on several tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer. Phosphorylation at Tyr-769 is essential for interaction with PLCG1.;N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.	MAPK signaling pathway;Endocytosis;Regulation of actin cytoskeleton;Pathways in cancer;Prostate cancer;RAF/MAP kinase cascade;FGFR2b ligand binding and activation;PI3K Cascade;PIP3 activates AKT signaling;FGFR2c ligand binding and activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade, FGFR2;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;Negative regulation of FGFR2 signaling;Signaling by FGFR2 in disease;Signaling by FGFR2 amplification mutants;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by FGFR2 IIIa TM;Signaling by FGFR2 fusions	PE1	10
+NX_P21810	Biglycan	368	41654	7.16	0	Endoplasmic reticulum;Golgi apparatus;Extracellular matrix	Meester-Loeys syndrome;Spondyloepimetaphyseal dysplasia, X-linked	May be involved in collagen fiber assembly.	The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Chondroitin sulfate biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;ECM proteoglycans;Dermatan sulfate biosynthesis;CS/DS degradation;Defective CHST3 causes SEDCJD;Defective CHST14 causes EDS, musculocontractural type;Defective CHSY1 causes TPBS;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	X
+NX_P21815	Bone sialoprotein 2	317	35148	4.14	0	Secreted	NA	Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.	N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains.;Sulfated on either Tyr-313 or Tyr-314.;O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc.	NA	Focal adhesion;ECM-receptor interaction;Integrin cell surface interactions;ECM proteoglycans	PE1	4
+NX_P21817	Ryanodine receptor 1	5038	565176	5.18	6	Golgi apparatus;Sarcoplasmic reticulum;Cytoplasmic vesicle;Cytosol;Sarcoplasmic reticulum membrane	Central core disease of muscle;Malignant hyperthermia 1;Multiminicore disease with external ophthalmoplegia	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).	Activated by reversible S-nitrosylation (By similarity). Repeated very high-level exercise increases S-nitrosylation (PubMed:18268335).;Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2843 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2843.	Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily.	Calcium signaling pathway;Long-term depression;Stimuli-sensing channels;Ion homeostasis	PE1	19
+NX_P21854	B-cell differentiation antigen CD72	359	40220	8.62	1	Membrane;Nucleoplasm;Mitochondrion	NA	Plays a role in B-cell proliferation and differentiation.	Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).	NA	B cell receptor signaling pathway;Other semaphorin interactions	PE1	9
+NX_P21860	Receptor tyrosine-protein kinase erbB-3	1342	148098	6.11	1	Secreted;Cytoskeleton;Cell membrane	Lethal congenital contracture syndrome 2;Erythroleukemia, familial	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).	Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).;ERBB3 is phosphorylated by CDK5;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.	ErbB signaling pathway;Calcium signaling pathway;Endocytosis;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;PI3K events in ERBB2 signaling;GRB7 events in ERBB2 signaling;Downregulation of ERBB2:ERBB3 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling	PE1	12
+NX_P21912	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	280	31630	9.03	0	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion;Cell membrane	Pheochromocytoma;Paragangliomas 4;Paraganglioma and gastric stromal sarcoma	Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	NA	Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.	Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.;Citrate cycle (TCA cycle);Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Citric acid cycle (TCA cycle)	PE1	1
+NX_P21917	D(4) dopamine receptor	419	43901	9.24	7	Cell membrane	NA	Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).	Palmitoylated. Palmitoylation of the C-terminal Cys is important for normal expression at the cell membrane.;Polyubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex: polyubiquitination does not lead to degradation of DRD4 protein.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Dopaminergic synapse;G alpha (i) signalling events;Dopamine receptors	PE1	11
+NX_P21918	D(1B) dopamine receptor	477	52951	5.23	7	Cell membrane	Benign essential blepharospasm	Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Dopaminergic synapse;G alpha (s) signalling events;Dopamine receptors	PE1	4
+NX_P21926	CD9 antigen	228	25416	6.8	4	Extracellular exosome;Cytoplasm;Membrane;Cell membrane	NA	Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:8478605, PubMed:14575715, PubMed:18541721). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (PubMed:18541721). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (PubMed:8478605, PubMed:7511626).	Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.	Belongs to the tetraspanin (TM4SF) family.	Hematopoietic cell lineage;Uptake and function of diphtheria toxin;Acrosome Reaction and Sperm:Oocyte Membrane Binding;Platelet degranulation	PE1	12
+NX_P21941	Cartilage matrix protein	496	53701	7.85	0	Extracellular matrix	NA	Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.	NA	NA	ECM proteoglycans	PE1	1
+NX_P21953	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial	392	43122	5.89	0	Mitochondrion matrix;Mitochondrion;Nucleolus	Maple syrup urine disease 1B	The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	NA	NA	Valine, leucine and isoleucine degradation;Metabolic pathways;Branched-chain amino acid catabolism;Glyoxylate metabolism and glycine degradation	PE1	6
+NX_P21964	Catechol O-methyltransferase	271	30037	5.26	1	Endoplasmic reticulum;Cytoplasm;Cytoplasmic vesicle;Cell membrane	Schizophrenia	Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.	The N-terminus is blocked.	Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.	Steroid hormone biosynthesis;Tyrosine metabolism;Metabolic pathways;Dopaminergic synapse;Methylation;Enzymatic degradation of dopamine by COMT;Enzymatic degradation of Dopamine by monoamine oxidase	PE1	22
+NX_P21980	Protein-glutamine gamma-glutamyltransferase 2	687	77329	5.11	0	Cytosol;Cell membrane	NA	Catalyzes the cross-linking of proteins, such as WDR54, and the conjugation of polyamines to proteins.	NA	Belongs to the transglutaminase superfamily. Transglutaminase family.	Huntington's disease	PE1	20
+NX_P22001	Potassium voltage-gated channel subfamily A member 3	575	63842	5.61	6	Cell membrane	NA	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.	N-glycosylation promotes the cell surface expression.	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.	Voltage gated Potassium channels	PE1	1
+NX_P22003	Bone morphogenetic protein 5	454	51737	9.07	0	Secreted	NA	Induces cartilage and bone formation.	NA	Belongs to the TGF-beta family.	Hedgehog signaling pathway;TGF-beta signaling pathway	PE1	6
+NX_P22004	Bone morphogenetic protein 6	513	57226	8.39	0	Mitochondrion;Secreted	NA	Induces cartilage and bone formation.	NA	Belongs to the TGF-beta family.	Hedgehog signaling pathway;TGF-beta signaling pathway	PE1	6
+NX_P22033	Methylmalonyl-CoA mutase, mitochondrial	750	83134	6.48	0	Mitochondrion matrix;Mitochondrion;Cytosol	Methylmalonic aciduria type mut	Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species.	NA	Belongs to the methylmalonyl-CoA mutase family.	Valine, leucine and isoleucine degradation;Glyoxylate and dicarboxylate metabolism;Propanoate metabolism;Metabolic pathways;Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective MMAA causes methylmalonic aciduria type cblA;Defective MUT causes methylmalonic aciduria mut type;Propionyl-CoA catabolism	PE1	6
+NX_P22059	Oxysterol-binding protein 1	807	89421	6.91	0	trans-Golgi network;Golgi apparatus;Endoplasmic reticulum membrane;Nucleoplasm;Golgi apparatus membrane;Cytosol;Perinuclear region	NA	Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).	NA	Belongs to the OSBP family.	Sphingolipid de novo biosynthesis;Synthesis of bile acids and bile salts	PE1	11
+NX_P22061	Protein-L-isoaspartate(D-aspartate) O-methyltransferase	227	24636	6.7	0	Cytoplasm;Cytosol	NA	Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.	NA	Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.	Protein repair	PE1	6
+NX_P22079	Lactoperoxidase	712	80288	8.89	0	Secreted	NA	Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection.	NA	Belongs to the peroxidase family. XPO subfamily.	Salivary secretion;Events associated with phagocytolytic activity of PMN cells	PE1	17
+NX_P22083	Alpha-(1,3)-fucosyltransferase 4	530	59084	10.04	1	Golgi stack membrane;Cytoplasmic vesicle	NA	May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.	NA	Belongs to the glycosyltransferase 10 family.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Lewis blood group biosynthesis	PE1	11
+NX_P22087	rRNA 2'-O-methyltransferase fibrillarin	321	33784	10.18	0	Nucleolus;Nucleus	NA	S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).	Ubiquitinated. Ubiquitination leads to proteasomal degradation (PubMed:19208757). Deubiquitinated by USP36 (PubMed:19208757).;By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).	Belongs to the methyltransferase superfamily. Fibrillarin family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	19
+NX_P22090	40S ribosomal protein S4, Y isoform 1	263	29456	10.25	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eS4 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	Y
+NX_P22102	Trifunctional purine biosynthetic protein adenosine-3	1010	107767	6.26	0	Nucleoplasm;Cytosol;Mitochondrion	NA	NA	NA	In the N-terminal section; belongs to the GARS family.;In the central section; belongs to the AIR synthase family.;In the C-terminal section; belongs to the GART family.	Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.;Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.;Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.;Purine metabolism;One carbon pool by folate;Metabolic pathways;Purine ribonucleoside monophosphate biosynthesis	PE1	21
+NX_P22105	Tenascin-X	4244	458388	5.05	0	Extracellular matrix	Ehlers-Danlos syndrome, classic-like;Vesicoureteral reflux 8	Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.	NA	Belongs to the tenascin family.	Focal adhesion;ECM-receptor interaction;ECM proteoglycans	PE1	6
+NX_P22223	Cadherin-3	829	91418	4.61	1	Cell junction;Cell membrane	Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome;Hypotrichosis congenital with juvenile macular dystrophy	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	Cell adhesion molecules (CAMs);Adherens junctions interactions	PE1	16
+NX_P22234	Multifunctional protein ADE2	425	47079	6.94	0	Cytosol	NA	NA	NA	In the N-terminal section; belongs to the SAICAR synthetase family.;In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.;Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.;Purine metabolism;Metabolic pathways;Purine ribonucleoside monophosphate biosynthesis	PE1	4
+NX_P22301	Interleukin-10	178	20517	8.19	0	Secreted	NA	Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).	NA	Belongs to the IL-10 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;T cell receptor signaling pathway;Intestinal immune network for IgA production;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);African trypanosomiasis;Malaria;Toxoplasmosis;Amoebiasis;Staphylococcus aureus infection;Tuberculosis;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Allograft rejection;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	1
+NX_P22303	Acetylcholinesterase	614	67796	5.87	0	Golgi apparatus;Cell membrane;Secreted;Synapse;Cytoplasmic vesicle;Nucleus	NA	Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.	NA	Belongs to the type-B carboxylesterase/lipase family.	Glycerophospholipid metabolism;Cholinergic synapse;Synthesis of PC;Synthesis, secretion, and deacylation of Ghrelin;Neurotransmitter clearance	PE1	7
+NX_P22304	Iduronate 2-sulfatase	550	61873	5.21	0	Endoplasmic reticulum;Lysosome	Mucopolysaccharidosis 2	Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Glycosaminoglycan degradation;Metabolic pathways;Lysosome;HS-GAG degradation;CS/DS degradation;MPS II - Hunter syndrome	PE1	X
+NX_P22307	Non-specific lipid-transfer protein	547	58994	6.44	0	Peroxisome;Cytoplasm;Mitochondrion	Leukoencephalopathy with dystonia and motor neuropathy	Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.	NA	In the N-terminal section; belongs to the thiolase-like superfamily. Thiolase family.	Primary bile acid biosynthesis;Metabolic pathways;PPAR signaling pathway;Peroxisome;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Beta-oxidation of pristanoyl-CoA;alpha-linolenic acid (ALA) metabolism;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins	PE1	1
+NX_P22309	UDP-glucuronosyltransferase 1-1	533	59591	8.19	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Microsome	Transient familial neonatal hyperbilirubinemia;Gilbert syndrome;Crigler-Najjar syndrome 2;Crigler-Najjar syndrome 1	Lacks transferase activity but acts as a negative regulator of isoform 1.;UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation;Defective UGT1A1 causes hyperbilirubinemia	PE1	2
+NX_P22310	UDP-glucuronosyltransferase 1-4	534	60025	8.79	1	Endoplasmic reticulum membrane;Microsome	NA	Lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).;UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation;Heme degradation;Defective UGT1A4 causes hyperbilirubinemia	PE1	2
+NX_P22314	Ubiquitin-like modifier-activating enzyme 1	1058	117849	5.49	0	Cytoplasm;Nucleoplasm;Mitochondrion;Nucleus	Spinal muscular atrophy X-linked 2	Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).	ISGylated.	Belongs to the ubiquitin-activating E1 family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Parkinson's disease;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	X
+NX_P22352	Glutathione peroxidase 3	226	25552	8.26	0	Secreted	NA	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.	The N-terminus is blocked.	Belongs to the glutathione peroxidase family.	Glutathione metabolism;Arachidonic acid metabolism;Detoxification of Reactive Oxygen Species	PE1	5
+NX_P22362	C-C motif chemokine 1	96	10992	9.3	0	Secreted	NA	Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	17
+NX_P22392	Nucleoside diphosphate kinase B	152	17298	8.52	0	Cytoplasm;Nucleoplasm;Lamellipodium;Ruffle;Cytosol;Nucleus	NA	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752, PubMed:19435876). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858).	NA	Belongs to the NDK family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;Purine metabolism;Pyrimidine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates;Neutrophil degranulation	PE1	17
+NX_P22413	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	925	104924	6.76	1	Basolateral cell membrane;Secreted;Cell membrane	Diabetes mellitus, non-insulin-dependent;Cole disease;Arterial calcification of infancy, generalized, 1;Hypophosphatemic rickets, autosomal recessive, 2;Ossification of the posterior longitudinal ligament of the spine	Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity). PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals (PubMed:11004006). Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP (PubMed:27467858, PubMed:8001561, PubMed:25344812). May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling (PubMed:27467858, PubMed:8001561). Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (By similarity). Appears to modulate insulin sensitivity and function (PubMed:10615944). Also involved in melanogenesis (PubMed:28964717). Also able to hydrolyze 2'-3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (PubMed:25344812). 2'-3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2'-3'-cGAMP hydrolysis is therefore unclear (PubMed:25344812). Not able to hydrolyze the 2'-3'-cGAMP linkage isomer 3'-3'-cGAMP (PubMed:25344812).	N-glycosylated.;Autophosphorylated as part of the catalytic cycle of phosphodiesterase/pyrophosphatase activity.;The secreted form is produced through cleavage at Lys-103 by intracellular processing.	Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.	Purine metabolism;Starch and sucrose metabolism;Riboflavin metabolism;Nicotinate and nicotinamide metabolism;Pantothenate and CoA biosynthesis;Metabolic pathways;Vitamin B2 (riboflavin) metabolism;Vitamin B5 (pantothenate) metabolism	PE1	6
+NX_P22415	Upstream stimulatory factor 1	310	33538	5.36	0	Nucleoplasm;Nucleus	Hyperlipidemia, familial combined, 1	Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.	NA	NA	Estrogen-dependent gene expression	PE1	1
+NX_P22455	Fibroblast growth factor receptor 4	802	87954	6.36	1	Cytoplasm;Cell membrane;Secreted;Endoplasmic reticulum;Endosome	Prostate cancer	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.	Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer.;N-glycosylated. Full maturation of the glycan chains in the Golgi is essential for high affinity interaction with FGF19.;Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.	MAPK signaling pathway;Endocytosis;Regulation of actin cytoskeleton;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;FGFR4 ligand binding and activation;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade, FGFR4;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR4 signaling;Signaling by FGFR4 in disease;betaKlotho-mediated ligand binding;FGFR4 mutant receptor activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	5
+NX_P22459	Potassium voltage-gated channel subfamily A member 4	653	73257	5.08	6	Axon;Cell membrane	Microcephaly, cataracts, impaired intellectual development, and dystonia with abnormal striatum	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368).	NA	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.	Voltage gated Potassium channels	PE1	11
+NX_P22460	Potassium voltage-gated channel subfamily A member 5	613	67228	5.68	6	Cell membrane	Atrial fibrillation, familial, 7	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets.;Exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).	Sumoylated on Lys-221, and Lys-536, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel.	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.	Voltage gated Potassium channels	PE1	12
+NX_P22466	Galanin peptides	123	13302	6.84	0	Golgi apparatus;Cytoplasmic vesicle;Secreted	Epilepsy, familial temporal lobe, 8	Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.	NA	Belongs to the galanin family.	G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	11
+NX_P22492	Histone H1t	207	22019	11.71	0	Nucleus;Chromosome	NA	Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).	Phosphorylated in early spermatids.;Citrullination at Arg-58 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.	Belongs to the histone H1/H5 family.	NA	PE1	6
+NX_P22528	Cornifin-B	89	9888	8.85	0	Cytoplasm	NA	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.	The N-terminus is blocked.	Belongs to the cornifin (SPRR) family.	Formation of the cornified envelope	PE1	1
+NX_P22531	Small proline-rich protein 2E	72	7855	8.73	0	Cytoplasm	NA	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.	NA	Belongs to the cornifin (SPRR) family.	Formation of the cornified envelope	PE2	1
+NX_P22532	Small proline-rich protein 2D	72	7905	8.77	0	Cytoplasm	NA	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.	NA	Belongs to the cornifin (SPRR) family.	Formation of the cornified envelope	PE1	1
+NX_P22557	5-aminolevulinate synthase, erythroid-specific, mitochondrial	587	64633	8.39	0	Mitochondrion matrix	Anemia, sideroblastic, 1;Erythropoietic protoporphyria, X-linked dominant	NA	NA	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.;Glycine, serine and threonine metabolism;Porphyrin and chlorophyll metabolism;Metabolic pathways;Heme biosynthesis	PE1	X
+NX_P22570	NADPH:adrenodoxin oxidoreductase, mitochondrial	491	53837	8.72	0	Mitochondrion inner membrane;Mitochondrion	Auditory neuropathy and optic atrophy	Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.	NA	Belongs to the ferredoxin--NADP reductase type 1 family.	Steroid metabolism; cholesterol metabolism.;Pregnenolone biosynthesis;Endogenous sterols;Electron transport from NADPH to Ferredoxin;Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	PE1	17
+NX_P22607	Fibroblast growth factor receptor 3	806	87710	5.59	1	Cytoplasmic vesicle;Endoplasmic reticulum;Secreted;Cell membrane	Lacrimo-auriculo-dento-digital syndrome;Camptodactyly, tall stature, and hearing loss syndrome;Bladder cancer;Keratinocytic non-epidermolytic nevus;Keratosis, seborrheic;Hypochondroplasia;Achondroplasia, severe, with developmental delay and acanthosis nigricans;Thanatophoric dysplasia 2;Achondroplasia;Multiple myeloma;Testicular germ cell tumor;Crouzon syndrome with acanthosis nigricans;Thanatophoric dysplasia 1;Cervical cancer;Muenke syndrome	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.	Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer. Phosphorylation at Tyr-724 is essential for stimulation of cell proliferation and activation of PIK3R1, STAT1 and MAP kinase signaling. Phosphorylation at Tyr-760 is required for interaction with PIK3R1 and PLCG1.;N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus.;Ubiquitinated. Is rapidly ubiquitinated after ligand binding and autophosphorylation, leading to receptor internalization and degradation. Subject to both proteasomal and lysosomal degradation.;Autophosphorylated	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.	MAPK signaling pathway;Endocytosis;Regulation of actin cytoskeleton;Pathways in cancer;Bladder cancer;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR3;FGFR3c ligand binding and activation;FGFR3 mutant receptor activation;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade, FGFR3;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;Negative regulation of FGFR3 signaling;FGFR3b ligand binding and activation;t(4;14) translocations of FGFR3;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR3 fusions in cancer	PE1	4
+NX_P22612	cAMP-dependent protein kinase catalytic subunit gamma	351	40434	8.7	0	NA	Bleeding disorder, platelet-type 19	Phosphorylates a large number of substrates in the cytoplasm and the nucleus.	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.	MAPK signaling pathway;Calcium signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Apoptosis;Vascular smooth muscle contraction;Wnt signaling pathway;Hedgehog signaling pathway;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Olfactory transduction;Taste transduction;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;MAPK6/MAPK4 signaling;Factors involved in megakaryocyte development and platelet production;VEGFA-VEGFR2 Pathway;Triglyceride catabolism;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;CD209 (DC-SIGN) signaling;Regulation of insulin secretion;PKA-mediated phosphorylation of CREB;PKA-mediated phosphorylation of key metabolic factors;Rap1 signalling;CREB1 phosphorylation through the activation of Adenylate Cyclase;RET signaling;HDL assembly;ROBO receptors bind AKAP5;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	9
+NX_P22626	Heterogeneous nuclear ribonucleoproteins A2/B1	353	37430	8.97	0	Extracellular exosome;Cytoplasm;Nucleoplasm;Cytoplasmic granule;Nucleus	Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2	(Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport.;Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays also a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558).	Asymmetric dimethylation at Arg-266 constitutes the major methylation site (By similarity). According to a report, methylation affects subcellular location and promotes nuclear localization (PubMed:10772824). According to another report, methylation at Arg-266 does not influence nucleocytoplasmic shuttling (By similarity).;Sumoylated in exosomes, promoting miRNAs-binding.;HNRNPA2B1 is phosphorylated by CSNK2A2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);HNRNPA2B1 is phosphorylated by FYN (Phosphotyrosine:PTM-0255)	NA	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	7
+NX_P22670	MHC class II regulatory factor RFX1	979	104758	5.89	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.	NA	Belongs to the RFX family.	NA	PE1	19
+NX_P22674	Cyclin-O	350	38096	8.44	0	Cytoplasm	Ciliary dyskinesia, primary, 29	Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.	NA	Belongs to the cyclin family.	NA	PE1	5
+NX_P22676	Calretinin	271	31540	5.06	0	Cytosol	NA	Calretinin is a calcium-binding protein which is abundant in auditory neurons.	NA	Belongs to the calbindin family.	NA	PE1	16
+NX_P22680	Cytochrome P450 7A1	504	57661	8.48	1	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:2384150, PubMed:21813643). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:2384150, PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:21813643). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (PubMed:12077124, PubMed:19965590, PubMed:2384150). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol (PubMed:11013305, PubMed:12077124). Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (PubMed:21813643).	NA	Belongs to the cytochrome P450 family.	Steroid metabolism; cholesterol degradation.;Lipid metabolism; bile acid biosynthesis.;Primary bile acid biosynthesis;Steroid hormone biosynthesis;Metabolic pathways;PPAR signaling pathway;Bile secretion;PPARA activates gene expression;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol;Endogenous sterols;Synthesis of bile acids and bile salts	PE1	8
+NX_P22681	E3 ubiquitin-protein ligase CBL	906	99633	6.1	0	Golgi apparatus;Cytoplasm;Cell membrane;Cilium;Cytosol	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).	Phosphorylated on tyrosine residues by ALK, EGFR, SYK, FYN and ZAP70 (By similarity). Phosphorylated on tyrosine residues in response to FLT1 and KIT signaling. Phosphorylated on tyrosine residues by INSR and FGR. Phosphorylated on several tyrosine residues by constitutively activated FGFR3. Not phosphorylated at Tyr-731 by FGFR3. Phosphorylated on tyrosine residues by activated CSF1R, PDGFRA and PDGFRB. Phosphorylated on tyrosine residues by HCK.;Ubiquitinated, leading to its degradation via the proteasome (PubMed:11896602, PubMed:20094046). Ubiquitination is negatively regulated by IFT20 (PubMed:29237719).;CBL is phosphorylated by ABL1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);CBL is phosphorylated by ALK (Phosphotyrosine:PTM-0255);CBL is phosphorylated by HCK	NA	Protein modification; protein ubiquitination.;ErbB signaling pathway;Ubiquitin mediated proteolysis;Endocytosis;Jak-STAT signaling pathway;T cell receptor signaling pathway;Insulin signaling pathway;Bacterial invasion of epithelial cells;Pathways in cancer;Chronic myeloid leukemia;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;EGFR downregulation;Regulation of KIT signaling;Regulation of signaling by CBL;Spry regulation of FGF signaling;TGF-beta receptor signaling activates SMADs;Interleukin-6 signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Constitutive Signaling by EGFRvIII;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Negative regulation of MET activity;InlB-mediated entry of Listeria monocytogenes into host cell	PE1	11
+NX_P22692	Insulin-like growth factor-binding protein 4	258	27934	6.81	0	Secreted	NA	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.	NA	NA	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	17
+NX_P22694	cAMP-dependent protein kinase catalytic subunit beta	351	40623	8.84	0	Membrane;Cytoplasm;Nucleus;Cell membrane	NA	Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142).	Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.	MAPK signaling pathway;Calcium signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Apoptosis;Vascular smooth muscle contraction;Wnt signaling pathway;Hedgehog signaling pathway;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Olfactory transduction;Taste transduction;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;MAPK6/MAPK4 signaling;Factors involved in megakaryocyte development and platelet production;VEGFA-VEGFR2 Pathway;Triglyceride catabolism;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;CD209 (DC-SIGN) signaling;Regulation of insulin secretion;PKA-mediated phosphorylation of CREB;PKA-mediated phosphorylation of key metabolic factors;Rap1 signalling;CREB1 phosphorylation through the activation of Adenylate Cyclase;RET signaling;HDL assembly;ROBO receptors bind AKAP5;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	1
+NX_P22695	Cytochrome b-c1 complex subunit 2, mitochondrial	453	48443	8.74	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex III deficiency, nuclear 5	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.	NA	Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport	PE1	16
+NX_P22732	Solute carrier family 2, facilitated glucose transporter member 5	501	54974	5.81	12	Apical cell membrane;Sarcolemma;Cell membrane	NA	Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543, PubMed:16186102, PubMed:28083649). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).	NA	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Carbohydrate digestion and absorption;Neutrophil degranulation;Intestinal hexose absorption	PE1	1
+NX_P22735	Protein-glutamine gamma-glutamyltransferase K	817	89787	5.68	0	Membrane	Ichthyosis, congenital, autosomal recessive 1	Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141).	Tyrosine-phosphorylated.;Palmitoylated.;The membrane anchorage region possesses a cluster of five cysteines within which fatty acid(s) may become thioester-linked. It is subject to phorbol ester-stimulated phosphorylation and is hypersensitive to proteolysis, which releases the enzyme in a soluble form.	Belongs to the transglutaminase superfamily. Transglutaminase family.	Formation of the cornified envelope	PE1	14
+NX_P22736	Nuclear receptor subfamily 4 group A member 1	598	64463	6.82	0	Cytoplasm;Mitochondrion;Nucleus membrane;Nucleoplasm;Cytosol;Nucleus	NA	Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).	Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1.;Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.;NR4A1 is phosphorylated by MAPK7 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the nuclear hormone receptor family. NR4 subfamily.	MAPK signaling pathway;Nuclear Receptor transcription pathway;AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer	PE1	12
+NX_P22748	Carbonic anhydrase 4	312	35032	7.68	0	Cytoplasmic vesicle;Cell membrane	Retinitis pigmentosa 17	Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.	NA	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Proximal tubule bicarbonate reclamation;Reversible hydration of carbon dioxide;Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide	PE1	17
+NX_P22749	Granulysin	145	16374	9.39	0	Secreted	NA	Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.	A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.	NA	Antimicrobial peptides	PE1	2
+NX_P22760	Arylacetamide deacetylase	399	45734	8.75	1	Microsome membrane;Endoplasmic reticulum membrane	NA	Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.	Glycosylation is required for enzyme activity.	Belongs to the 'GDXG' lipolytic enzyme family.	Phase I - Functionalization of compounds	PE1	3
+NX_P22792	Carboxypeptidase N subunit 2	545	60557	5.63	0	Secreted	NA	The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.	Whether or not any Cys residues participate in intrachain bonds is unknown, but they do not form interchain disulfide bonds with the 50 kDa catalytic subunit.	NA	Regulation of Complement cascade	PE1	3
+NX_P22794	Protein EVI2A	236	26213	8.73	1	Membrane;Nucleoplasm;Nucleus	NA	May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.	NA	Belongs to the EVI2A family.	NA	PE1	17
+NX_P22830	Ferrochelatase, mitochondrial	423	47862	8.96	0	Mitochondrion inner membrane	Protoporphyria, erythropoietic, 1	Catalyzes the ferrous insertion into protoporphyrin IX.	NA	Belongs to the ferrochelatase family.	Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.;Porphyrin and chlorophyll metabolism;Metabolic pathways;Heme biosynthesis	PE1	18
+NX_P22888	Lutropin-choriogonadotropic hormone receptor	699	78643	8.82	7	Cell membrane	Luteinizing hormone resistance;Familial male precocious puberty	Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).	Sulfated.	Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Hormone ligand-binding receptors	PE1	2
+NX_P22891	Vitamin K-dependent protein Z	400	44744	5.64	0	Secreted	NA	Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.	Belongs to the peptidase S1 family.	Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins	PE1	13
+NX_P22894	Neutrophil collagenase	467	53412	6.38	0	Cytoplasmic granule;Extracellular matrix	NA	Can degrade fibrillar type I, II, and III collagens.	NA	Belongs to the peptidase M10A family.	Degradation of the extracellular matrix;Collagen degradation;Activation of Matrix Metalloproteinases;Neutrophil degranulation	PE1	11
+NX_P22897	Macrophage mannose receptor 1	1456	166012	6.11	1	Endosome membrane;Cell membrane	NA	Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.;(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.;(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.;(Microbial infection) Interacts with Hepatitis B virus envelope protein.	NA	NA	Phagosome;Tuberculosis;Cross-presentation of soluble exogenous antigens (endosomes)	PE1	10
+NX_P22914	Gamma-crystallin S	178	21007	6.44	0	Cytosol	Cataract 20, multiple types	Crystallins are the dominant structural components of the vertebrate eye lens.	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	3
+NX_P23025	DNA repair protein complementing XP-A cells	273	31368	6.29	0	Nucleoplasm;Nucleus;Cytoskeleton	Xeroderma pigmentosum complementation group A	Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.	ATR-dependent phosphorylation of XPA at Ser-196 is important for cell survival in response to UV damage.;Ubiquitinated by HERC2 leading to degradation by the proteasome.;XPA is phosphorylated by ATR (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the XPA family.	Formation of TC-NER Pre-Incision Complex;Dual incision in TC-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER	PE1	9
+NX_P23083	Immunoglobulin heavy variable 1-2	117	13085	9.23	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	14
+NX_P23109	AMP deaminase 1	780	90219	6.53	0	NA	Myopathy due to myoadenylate deaminase deficiency	AMP deaminase plays a critical role in energy metabolism.	NA	Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.;Purine metabolism;Metabolic pathways;Purine salvage	PE1	1
+NX_P23141	Liver carboxylesterase 1	567	62521	6.15	0	Endoplasmic reticulum;Endoplasmic reticulum lumen	NA	Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.	Contains sialic acid.;Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19.	Belongs to the type-B carboxylesterase/lipase family.	Drug metabolism - other enzymes;Metabolic pathways;Metabolism of Angiotensinogen to Angiotensins;Phase I - Functionalization of compounds	PE1	16
+NX_P23142	Fibulin-1	703	77214	5.07	0	Endoplasmic reticulum;Extracellular matrix	NA	Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.	NA	Belongs to the fibulin family.	Molecules associated with elastic fibres	PE1	22
+NX_P23193	Transcription elongation factor A protein 1	301	33970	8.65	0	Nucleoplasm;Nucleolus;Nucleus	NA	Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.	NA	Belongs to the TFS-II family.	Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes	PE1	8
+NX_P23219	Prostaglandin G/H synthase 1	599	68686	6.81	0	Microsome membrane;Cytoplasmic vesicle;Golgi apparatus;Endoplasmic reticulum membrane	NA	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.	NA	Belongs to the prostaglandin G/H synthase family.	Lipid metabolism; prostaglandin biosynthesis.;Arachidonic acid metabolism;Metabolic pathways;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);COX reactions	PE1	9
+NX_P23229	Integrin alpha-6	1130	126606	6.21	1	Cell membrane	Epidermolysis bullosa letalis, with pyloric atresia	Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).	Palmitoylation by DHHC3 enhances stability and cell surface expression.;Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.;Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p) (PubMed:11359780, PubMed:15023541, PubMed:17303120). Production of alpha6p enhances prostate cancer cell invasion and migration (PubMed:17303120).	Belongs to the integrin alpha chain family.	Focal adhesion;ECM-receptor interaction;Cell adhesion molecules (CAMs);Hematopoietic cell lineage;Regulation of actin cytoskeleton;Toxoplasmosis;Pathways in cancer;Small cell lung cancer;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Syndecan interactions;Integrin cell surface interactions;Basigin interactions;Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly;Laminin interactions	PE1	2
+NX_P23246	Splicing factor, proline- and glutamine-rich	707	76149	9.45	0	Nucleoplasm;Nucleus matrix;Cytoplasm;Nucleus speckle	NA	DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).	The N-terminus is blocked.;Phosphorylated on multiple serine and threonine residues during apoptosis. In vitro phosphorylated by PKC. Phosphorylation stimulates binding to DNA and D-loop formation, but inhibits binding to RNA. Phosphorylation of C-terminal tyrosines promotes its cytoplasmic localization, impaired its binding to polypyrimidine RNA and led to cell cycle arrest. In resting T-cells is phosphorylated at Thr-687 by GSK3B which is proposed to promote association with THRAP and to prevent binding to PTPRC/CD45 pre-mRNA; T-cell activation leads to reduced phosphorylation at Thr-687.;SFPQ is phosphorylated by PTK6 (Phosphotyrosine:PTM-0255)	NA	PTK6 Regulates Proteins Involved in RNA Processing	PE1	1
+NX_P23258	Tubulin gamma-1 chain	451	51170	5.75	0	Centrosome	Cortical dysplasia, complex, with other brain malformations 4	Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.	Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.	Belongs to the tubulin family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	17
+NX_P23276	Kell blood group glycoprotein	732	82824	8.09	1	Nucleoplasm;Cytosol;Cell membrane	NA	Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.	N-glycosylated.	Belongs to the peptidase M13 family.	Peptide ligand-binding receptors	PE1	7
+NX_P23280	Carbonic anhydrase 6	308	35367	6.51	0	Secreted	NA	Reversible hydration of carbon dioxide. Its role in saliva is unknown.	NA	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Reversible hydration of carbon dioxide	PE1	1
+NX_P23284	Peptidyl-prolyl cis-trans isomerase B	216	23743	9.42	0	Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum lumen;Melanosome	Osteogenesis imperfecta 9	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.	NA	Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.	Collagen biosynthesis and modifying enzymes	PE1	15
+NX_P23297	Protein S100-A1	94	10546	4.39	0	Cytoplasm	NA	Probably acts as a Ca(2+) signal transducer (PubMed:22399290). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (PubMed:22399290).	NA	Belongs to the S-100 family.	Regulation of TLR by endogenous ligand	PE1	1
+NX_P23327	Sarcoplasmic reticulum histidine-rich calcium-binding protein	699	80244	4.62	0	Sarcoplasmic reticulum lumen	NA	May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.	NA	Belongs to the HRC family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	19
+NX_P23352	Anosmin-1	680	76112	9.33	0	Secreted;Cell membrane	Hypogonadotropic hypogonadism 1 with or without anosmia	Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells.	N-glycosylated.;May be proteolytically cleaved at the cell surface and released from the cell surface.	NA	FGFR1c ligand binding and activation;Negative regulation of FGFR1 signaling	PE1	X
+NX_P23368	NAD-dependent malic enzyme, mitochondrial	584	65444	7.52	0	Mitochondrion matrix;Mitochondrion	NA	NA	NA	Belongs to the malic enzymes family.	Pyruvate metabolism;Citric acid cycle (TCA cycle)	PE1	18
+NX_P23378	Glycine dehydrogenase (decarboxylating), mitochondrial	1020	112730	6.68	0	Nucleoplasm;Mitochondrion	Non-ketotic hyperglycinemia	The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).	NA	Belongs to the GcvP family.	Glycine, serine and threonine metabolism;Metabolic pathways;Glycine degradation	PE1	9
+NX_P23381	Tryptophan--tRNA ligase, cytoplasmic	471	53165	5.83	0	Cytoplasm;Cytosol	Neuronopathy, distal hereditary motor, 9	T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it.;T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.	Proteolytic cleavage generates 2 forms; T1-TrpRS and T2-TrpRS.	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation	PE1	14
+NX_P23396	40S ribosomal protein S3	243	26688	9.68	0	Cytoplasm;Nucleolus;Endoplasmic reticulum;Spindle;Cytosol;Mitochondrion inner membrane;Nucleus	NA	Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).	Sumoylation by SUMO1 enhances protein stability through increased resistance to proteolysis. Sumoylation occurs at one or more of the three consensus sites, Lys-18, Lys-214 and Lys-230.;Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.;Ubiquitinated (PubMed:16314389). This is prevented by interaction with HSP90 which stabilizes the protein (PubMed:16314389). Monoubiquitinated at Lys-214 by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).;Phosphorylation at Thr-221 by CDK1 occurs mainly in G2/M phase (PubMed:21871177). Phosphorylation by PRKCD occurs on a non-ribosomal-associated form which results in translocation of RPS3 to the nucleus and enhances its endonuclease activity (PubMed:19059439). Phosphorylated on Ser-209 by IKKB in response to activation of the NF-kappa-B p65-p50 complex which enhances the association of RPS3 with importin-alpha and mediates the nuclear translocation of RPS3 (PubMed:21399639). Phosphorylation by MAPK is required for translocation to the nucleus following exposure of cells to DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Phosphorylation by PKB/AKT mediates RPS3 nuclear translocation, enhances RPS3 endonuclease activity and suppresses RPS3-induced neuronal apoptosis (PubMed:20605787).;RPS3 is phosphorylated by MAPK3	Belongs to the universal ribosomal protein uS3 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	11
+NX_P23409	Myogenic factor 6	242	26953	5.71	0	Nucleus	NA	Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.	NA	NA	Myogenesis	PE1	12
+NX_P23415	Glycine receptor subunit alpha-1	457	52624	8.97	4	Postsynaptic cell membrane;Cell membrane;Perikaryon;Synapse;Dendrite	Hyperekplexia 1	Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.	Neuroactive ligand-receptor interaction;Neurotransmitter receptors and postsynaptic signal transmission	PE1	5
+NX_P23416	Glycine receptor subunit alpha-2	452	52002	9.06	4	Cell membrane;Cell projection;Synapse;Postsynaptic cell membrane	NA	Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467).	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub-subfamily.	Neuroactive ligand-receptor interaction;Neurotransmitter receptors and postsynaptic signal transmission	PE1	X
+NX_P23434	Glycine cleavage system H protein, mitochondrial	173	18885	4.91	0	Cytoplasmic vesicle;Mitochondrion	Non-ketotic hyperglycinemia	The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).	NA	Belongs to the GcvH family.	Glyoxylate metabolism and glycine degradation;Glycine degradation	PE1	16
+NX_P23435	Cerebellin-1	193	21097	6.73	0	Secreted;Postsynaptic cell membrane	NA	The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity).;Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (PubMed:27418511).	The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein.	NA	NA	PE1	16
+NX_P23443	Ribosomal protein S6 kinase beta-1	525	59140	6.21	0	Mitochondrion outer membrane;Cytoplasm;Mitochondrion;Synaptosome;Nucleoplasm;Nucleus	NA	Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239).	Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an agonist-dependent autophosphorylation mechanism (By similarity). Activated by phosphorylation at Thr-252 by PDPK1. Dephosphorylation by PPP1CC at Thr-412 in mitochondrion.;RPS6KB1 is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	ErbB signaling pathway;mTOR signaling pathway;TGF-beta signaling pathway;Fc gamma R-mediated phagocytosis;Insulin signaling pathway;Acute myeloid leukemia;mTORC1-mediated signalling	PE1	17
+NX_P23458	Tyrosine-protein kinase JAK1	1154	133277	7.48	0	Endomembrane system	NA	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).	Ubiquitinated by RNF125; leading to its degradation by the proteasome.;Autophosphorylated (PubMed:7615558). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558). Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529).	Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.	Osteoclast differentiation;Jak-STAT signaling pathway;Leishmaniasis;Toxoplasmosis;Tuberculosis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Herpes simplex infection;Pathways in cancer;Pancreatic cancer;ISG15 antiviral mechanism;RAF/MAP kinase cascade;Interferon gamma signaling;Interferon alpha/beta signaling;Interleukin-7 signaling;Interleukin receptor SHC signaling;Regulation of IFNA signaling;MAPK3 (ERK1) activation;Regulation of IFNG signaling;Interleukin-6 signaling;MAPK1 (ERK2) activation;Interleukin-20 family signaling;IL-6-type cytokine receptor ligand interactions;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Other interleukin signaling;Interleukin-15 signaling;Interleukin-35 Signalling;Interleukin-9 signaling;Interleukin-12 signaling;Interleukin-2 signaling;Interleukin-21 signaling;Interleukin-27 signaling	PE1	1
+NX_P23467	Receptor-type tyrosine-protein phosphatase beta	1997	224301	7.44	1	Membrane;Cytoplasmic vesicle;Cell junction;Cell membrane	NA	Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).	NA	Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.	Adherens junction;Neutrophil degranulation	PE1	12
+NX_P23468	Receptor-type tyrosine-protein phosphatase delta	1912	214760	6.14	1	Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.	A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.	Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.	Synaptic adhesion-like molecules;Receptor-type tyrosine-protein phosphatases	PE1	9
+NX_P23469	Receptor-type tyrosine-protein phosphatase epsilon	700	80642	6.57	1	Cytoplasm;Cytoskeleton;Cell membrane	NA	Plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).;Acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).;Act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).	Is glycosylated.;Are phosphorylated on tyrosine residues by tyrosine kinase Neu.;A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3.	Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.	NA	PE1	10
+NX_P23470	Receptor-type tyrosine-protein phosphatase gamma	1445	162003	5.99	1	Membrane;Cell membrane	NA	Possesses tyrosine phosphatase activity.	NA	Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.	NA	PE1	3
+NX_P23471	Receptor-type tyrosine-protein phosphatase zeta	2315	254587	4.76	1	Cytoplasmic vesicle;Cytosol;Secreted;Cell membrane	NA	Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).	NA	Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.	Epithelial cell signaling in Helicobacter pylori infection;Other interleukin signaling	PE1	7
+NX_P23490	Loricrin	312	25761	8.5	0	Nucleoplasm;Cytoplasm	Vohwinkel syndrome with ichthyosis	Major keratinocyte cell envelope protein.	Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.;Contains inter- or intramolecular disulfide-bonds.	NA	Formation of the cornified envelope	PE1	1
+NX_P23497	Nuclear autoantigen Sp-100	879	100417	8.49	0	Nucleoplasm;Nucleus;Cytoplasm;PML body	NA	Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.	Sumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting.;Sumoylated. Sumoylated with SUMO1. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting. Sumoylation may stabilize the interaction with CBX5.	NA	Herpes simplex infection;SUMOylation of DNA damage response and repair proteins;Interferon gamma signaling	PE1	2
+NX_P23508	Colorectal mutant cancer protein	829	93027	5.4	0	Cytoplasm;Cell membrane;Nucleoplasm;Lamellipodium;Cytosol;Nucleus	NA	Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).	NA	Belongs to the MCC family.	NA	PE1	5
+NX_P23510	Tumor necrosis factor ligand superfamily member 4	183	21050	6.95	1	Membrane;Nucleoplasm;Cytoplasmic vesicle	Systemic lupus erythematosus	Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.	NA	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	1
+NX_P23511	Nuclear transcription factor Y subunit alpha	347	36877	8.89	0	Nucleoplasm;Nucleus	NA	Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.	NA	Belongs to the NFYA/HAP2 subunit family.	Antigen processing and presentation;Tuberculosis;PPARA activates gene expression;ATF4 activates genes in response to endoplasmic reticulum stress;Activation of gene expression by SREBF (SREBP);ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes	PE1	6
+NX_P23515	Oligodendrocyte-myelin glycoprotein	440	49608	8.06	0	Cell membrane	NA	Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.	O-glycosylated in its Ser/Thr-rich repeat domain.	NA	Axonal growth inhibition (RHOA activation)	PE1	17
+NX_P23526	Adenosylhomocysteinase	432	47716	5.92	0	Cytoplasm;Cytosol;Melanosome	Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency	Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.	NA	Belongs to the adenosylhomocysteinase family.	Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.;Cysteine and methionine metabolism;Metabolic pathways;Methylation;Sulfur amino acid metabolism;Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD);Metabolism of ingested SeMet, Sec, MeSec into H2Se	PE1	20
+NX_P23527	Histone H2B type 1-O	126	13906	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_P23528	Cofilin-1	166	18502	8.22	0	Nucleus matrix;Lamellipodium membrane;Lamellipodium;Ruffle membrane;Cytoskeleton	NA	Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).	Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2.	Belongs to the actin-binding proteins ADF family.	Axon guidance;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Pertussis;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Platelet degranulation;Sema3A PAK dependent Axon repulsion;RHO GTPases Activate ROCKs;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	11
+NX_P23560	Brain-derived neurotrophic factor	247	27818	9.01	0	Nucleus speckle;Mitochondrion;Secreted	Congenital central hypoventilation syndrome	BDNF precursor form: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity).;Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.	BDNF precursor form: N-glycosylated and glycosulfated, contrary to mature BDNF.;Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF (PubMed:11152678). Can be converted into mature BDNF by plasmin (PLG) (PubMed:19467646).	Belongs to the NGF-beta family.	MAPK signaling pathway;Neurotrophin signaling pathway;Huntington's disease;Activated NTRK2 signals through RAS;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through CDK5;NTRK2 activates RAC1;Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through PI3K;Activated NTRK2 signals through FYN;BDNF activates NTRK2 (TRKB) signaling;MECP2 regulates transcription of neuronal ligands	PE1	11
+NX_P23582	C-type natriuretic peptide	126	13246	10.25	0	Secreted	NA	Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).	NA	Belongs to the natriuretic peptide family.	Physiological factors	PE1	2
+NX_P23588	Eukaryotic translation initiation factor 4B	611	69151	5.55	0	Cytosol	NA	Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.	Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.	NA	RNA transport;mTOR signaling pathway;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Deadenylation of mRNA;mTORC1-mediated signalling;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	PE1	12
+NX_P23610	40-kDa huntingtin-associated protein	371	39103	6.37	0	Cytoplasm;Early endosome;Nuclear body;Nucleus	NA	RAB5A effector molecule that is involved in vesicular trafficking of early endosomes (PubMed:16476778). Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778).	NA	NA	NA	PE1	X
+NX_P23634	Plasma membrane calcium-transporting ATPase 4	1241	137920	6.19	10	Flagellum membrane;Cell membrane	NA	Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity).	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.	Calcium signaling pathway;Salivary secretion;Pancreatic secretion;Ion transport by P-type ATPases;Reduction of cytosolic Ca++ levels;Ion homeostasis	PE1	1
+NX_P23677	Inositol-trisphosphate 3-kinase A	461	51009	7.59	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the inositol phosphokinase (IPK) family.	Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Phosphatidylinositol signaling system;Synthesis of IP3 and IP4 in the cytosol	PE1	15
+NX_P23743	Diacylglycerol kinase alpha	735	82630	6.28	0	Cytoplasmic vesicle;Nucleoplasm;Mitochondrion	NA	Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.	NA	Belongs to the eukaryotic diacylglycerol kinase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Effects of PIP2 hydrolysis	PE1	12
+NX_P23759	Paired box protein Pax-7	505	55119	9.1	0	Nucleus	Rhabdomyosarcoma 2	Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.	NA	Belongs to the paired homeobox family.	NA	PE1	1
+NX_P23760	Paired box protein Pax-3	479	52968	8.92	0	Nucleoplasm;Nucleus	Waardenburg syndrome 1;Rhabdomyosarcoma 2;Craniofacial-deafness-hand syndrome;Waardenburg syndrome 3	Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087).	NA	Belongs to the paired homeobox family.	HATs acetylate histones	PE1	2
+NX_P23763	Vesicle-associated membrane protein 1	118	12902	6.24	1	Mitochondrion outer membrane;Cytoplasmic vesicle membrane;Synaptic vesicle membrane;Synaptosome	Spastic ataxia 1, autosomal dominant;Myasthenic syndrome, congenital, 25, presynaptic	Involved in the targeting and/or fusion of transport vesicles to their target membrane.	(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which probably hydrolyzes the 68-Arg-|-Ala-69 bond and inhibits neurotransmitter release (PubMed:29540745). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.;(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which probably hydrolyzes the 60-Gln-|-Lys-61 bond and inhibits neurotransmitter release (PubMed:22289120).;(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 61-Arg-|-Leu-62 bond and inhibits neurotransmitter release (PubMed:22289120). BoNT/D has low catalytic activity on this protein due to its sequence (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.;(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which probably hydrolyzes the 78-Gln-|-Phe-79 bond and inhibits neurotransmitter release (PubMed:22289120).	Belongs to the synaptobrevin family.	SNARE interactions in vesicular transport;Toxicity of botulinum toxin type D (BoNT/D);Toxicity of botulinum toxin type F (BoNT/F);Toxicity of botulinum toxin type G (BoNT/G)	PE1	12
+NX_P23769	Endothelial transcription factor GATA-2	480	50500	9.43	0	Nucleoplasm;Nucleus	Myelodysplastic syndrome;Immunodeficiency 21;Lymphedema, primary, with myelodysplasia	Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.	NA	NA	Factors involved in megakaryocyte development and platelet production;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Transcriptional regulation of granulopoiesis	PE1	3
+NX_P23771	Trans-acting T-cell-specific transcription factor GATA-3	443	47916	9.52	0	Nucleoplasm;Nucleus	Hypoparathyroidism, sensorineural deafness, and renal disease	Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.	NA	NA	Factors involved in megakaryocyte development and platelet production;Ub-specific processing proteases;Interleukin-4 and Interleukin-13 signaling;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression	PE1	10
+NX_P23786	Carnitine O-palmitoyltransferase 2, mitochondrial	658	73777	8.38	0	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion;Nucleolus	Carnitine palmitoyltransferase 2 deficiency, lethal neonatal;Encephalopathy, acute, infection-induced, 4;Carnitine palmitoyltransferase 2 deficiency, myopathic, stress-induced;Carnitine palmitoyltransferase 2 deficiency, infantile	NA	NA	Belongs to the carnitine/choline acetyltransferase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid metabolism;PPAR signaling pathway;PPARA activates gene expression;Import of palmitoyl-CoA into the mitochondrial matrix	PE1	1
+NX_P23919	Thymidylate kinase	212	23819	8.4	0	Mitochondrion	NA	Catalyzes the conversion of dTMP to dTDP.	NA	Belongs to the thymidylate kinase family.	Pyrimidine metabolism; dTTP biosynthesis.;Pyrimidine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	2
+NX_P23921	Ribonucleoside-diphosphate reductase large subunit	792	90070	6.76	0	Cytoplasm;Cytosol	NA	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	NA	Belongs to the ribonucleoside diphosphate reductase large chain family.	Genetic information processing; DNA replication.;Purine metabolism;Pyrimidine metabolism;Glutathione metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	11
+NX_P23942	Peripherin-2	346	39186	8.5	4	Membrane;Photoreceptor outer segment;Photoreceptor inner segment	Macular dystrophy, vitelliform, 3;Retinitis pigmentosa 7;Macular dystrophy, patterned, 1;Choroidal dystrophy, central areolar 2;Retinitis punctata albescens	Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity).	NA	Belongs to the PRPH2/ROM1 family.	Amyotrophic lateral sclerosis (ALS)	PE1	6
+NX_P23945	Follicle-stimulating hormone receptor	695	78265	6.77	7	Cell membrane	Ovarian hyperstimulation syndrome;Ovarian dysgenesis 1	G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690).	Sulfated.;N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.;FSHR is phosphorylated by GRK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Hormone ligand-binding receptors	PE1	2
+NX_P23946	Chymase	247	27325	9.44	0	Cytoplasmic granule;Secreted	NA	Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.	NA	Belongs to the peptidase S1 family. Granzyme subfamily.	Renin-angiotensin system;Signaling by SCF-KIT;Activation of Matrix Metalloproteinases;Metabolism of Angiotensinogen to Angiotensins	PE1	14
+NX_P23975	Sodium-dependent noradrenaline transporter	617	69332	7.18	12	Cytosol;Mitochondrion;Cell membrane	Orthostatic intolerance	Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily.	Na+/Cl- dependent neurotransmitter transporters;Defective SLC6A2 causes orthostatic intolerance (OI)	PE1	16
+NX_P24001	Interleukin-32	234	26676	5.14	0	Secreted	NA	Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.	NA	NA	Other interleukin signaling	PE1	16
+NX_P24043	Laminin subunit alpha-2	3122	343905	6.01	0	Basement membrane	Muscular dystrophy, limb-girdle, autosomal recessive 23;Merosin-deficient congenital muscular dystrophy 1A	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	NA	NA	Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Viral myocarditis;ECM proteoglycans;Non-integrin membrane-ECM interactions;Laminin interactions;MET activates PTK2 signaling	PE1	6
+NX_P24046	Gamma-aminobutyric acid receptor subunit rho-1	479	55883	8.71	4	Postsynaptic cell membrane;Cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;GABA receptor activation	PE2	6
+NX_P24071	Immunoglobulin alpha Fc receptor	287	32265	6.44	1	Secreted;Cell membrane	NA	Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.	NA	NA	Phagosome;Staphylococcus aureus infection;Neutrophil degranulation	PE1	19
+NX_P24158	Myeloblastin	256	27807	8.72	0	Cytoplasmic granule;Membrane raft;Secreted;Cell membrane	NA	Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).	NA	Belongs to the peptidase S1 family. Elastase subfamily.	Common Pathway of Fibrin Clot Formation;Neutrophil degranulation;Antimicrobial peptides;Other interleukin signaling	PE1	19
+NX_P24278	Zinc finger and BTB domain-containing protein 25	435	48990	6.09	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	14
+NX_P24298	Alanine aminotransferase 1	496	54637	6.77	0	Cytoplasm	NA	Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).	NA	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.	Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.;Alanine, aspartate and glutamate metabolism;Metabolic pathways;Alanine metabolism	PE1	8
+NX_P24310	Cytochrome c oxidase subunit 7A1, mitochondrial	79	9118	10.12	1	Mitochondrion inner membrane	NA	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase VIIa family.	Oxidative phosphorylation;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease	PE1	19
+NX_P24311	Cytochrome c oxidase subunit 7B, mitochondrial	80	9161	10.28	1	Mitochondrion inner membrane	Linear skin defects with multiple congenital anomalies 2	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates.	NA	Belongs to the cytochrome c oxidase VIIb family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	X
+NX_P24347	Stromelysin-3	488	54590	6.38	0	Extracellular matrix	NA	May play an important role in the progression of epithelial malignancies.	The precursor is cleaved by a furin endopeptidase.	Belongs to the peptidase M10A family.	Degradation of the extracellular matrix;Collagen degradation;Activation of Matrix Metalloproteinases	PE1	22
+NX_P24385	G1/S-specific cyclin-D1	295	33729	4.97	0	Cytoplasm;Nucleoplasm;Nucleus membrane;Nucleus	Multiple myeloma	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.	Ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB. Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. SCF-type ubiquitination is dependent on Thr-286 phosphorylation (By similarity). Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization.;Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.	Belongs to the cyclin family. Cyclin D subfamily.	Cell cycle;p53 signaling pathway;Wnt signaling pathway;Focal adhesion;Jak-STAT signaling pathway;Measles;HTLV-I infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Thyroid cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Viral myocarditis;RMTs methylate histone arginines;SCF(Skp2)-mediated degradation of p27/p21;Pre-NOTCH Transcription and Translation;Cyclin D associated events in G1;PTK6 Regulates Cell Cycle;Interleukin-4 and Interleukin-13 signaling;RUNX3 regulates WNT signaling;RUNX3 regulates p14-ARF;Transcriptional regulation by RUNX2;Regulation of RUNX1 Expression and Activity;Estrogen-dependent gene expression;Ubiquitin-dependent degradation of Cyclin D;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	11
+NX_P24386	Rab proteins geranylgeranyltransferase component A 1	653	73476	4.68	0	Nucleoplasm;Cytosol	Choroideremia	Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.	NA	Belongs to the Rab GDI family.	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	X
+NX_P24387	Corticotropin-releasing factor-binding protein	322	36144	6.06	0	Secreted	NA	Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.	NA	Belongs to the CRF-binding protein family.	Class B/2 (Secretin family receptors)	PE1	5
+NX_P24390	ER lumen protein-retaining receptor 1	212	24542	8.8	7	Endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi apparatus;Endoplasmic reticulum membrane;COPI-coated vesicle membrane;Golgi apparatus membrane;Cytoplasmic vesicle;Cytosol	NA	Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.	Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function.	Belongs to the ERD2 family.	Vibrio cholerae infection;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	19
+NX_P24394	Interleukin-4 receptor subunit alpha	825	89658	4.99	1	Nucleoplasm;Centriolar satellite;Secreted;Cell membrane	NA	Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.;Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.	On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.;The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.	Belongs to the type I cytokine receptor family. Type 4 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Interleukin-4 and Interleukin-13 signaling	PE1	16
+NX_P24462	Cytochrome P450 3A7	503	57470	9.16	0	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PubMed:9555064, PubMed:11093772, PubMed:14559847, PubMed:12865317, PubMed:17178770). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9555064, PubMed:11093772, PubMed:14559847, PubMed:12865317, PubMed:17178770). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones (PubMed:9555064, PubMed:17178770). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position (PubMed:14559847, PubMed:12865317). Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics including anticonvulsants (PubMed:9555064).	NA	Belongs to the cytochrome P450 family.	Cofactor metabolism; retinol metabolism.;Steroid hormone biosynthesis.;Steroid hormone biosynthesis;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Xenobiotics	PE1	7
+NX_P24468	COUP transcription factor 2	414	45571	8.66	0	Nucleus	Congenital heart defects, multiple types, 4	Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.	NA	Belongs to the nuclear hormone receptor family. NR2 subfamily.	Transcriptional regulation of white adipocyte differentiation	PE1	15
+NX_P24522	Growth arrest and DNA damage-inducible protein GADD45 alpha	165	18336	4.36	0	Nucleus speckle;Nucleus	NA	In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.	NA	Belongs to the GADD45 family.	MAPK signaling pathway;Cell cycle;p53 signaling pathway;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;FOXO-mediated transcription of cell cycle genes	PE1	1
+NX_P24530	Endothelin receptor type B	442	49644	9.15	7	Cytosol;Cell membrane	ABCD syndrome;Waardenburg syndrome 4A;Hirschsprung disease 2	Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405.;EDNRB is phosphorylated by GRK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Melanogenesis;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	13
+NX_P24534	Elongation factor 1-beta	225	24764	4.5	0	Cytosol;Nucleolus	NA	EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.	Phosphorylation affects the GDP/GTP exchange rate.	Belongs to the EF-1-beta/EF-1-delta family.	Eukaryotic Translation Elongation	PE1	2
+NX_P24539	ATP synthase F(0) complex subunit B1, mitochondrial	256	28909	9.37	0	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.	NA	Belongs to the eukaryotic ATPase B chain family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	1
+NX_P24557	Thromboxane-A synthase	533	60518	7.56	4	Endoplasmic reticulum membrane	Ghosal hematodiaphyseal dysplasia	NA	NA	Belongs to the cytochrome P450 family.	Arachidonic acid metabolism;Metabolic pathways;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Eicosanoids;Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)	PE1	7
+NX_P24588	A-kinase anchor protein 5	427	47088	4.87	0	Membrane;Nucleoplasm	NA	May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.	Palmitoylation at Cys-36 and Cys-129 plays a key role in targeting to lipid rafts.;AKAP5 is phosphorylated by PRKACA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Trafficking of AMPA receptors;ROBO receptors bind AKAP5	PE1	14
+NX_P24592	Insulin-like growth factor-binding protein 6	240	25322	8.15	0	Secreted	NA	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.	O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.	NA	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	PE1	12
+NX_P24593	Insulin-like growth factor-binding protein 5	272	30570	8.58	0	Golgi apparatus;Secreted;Nucleus;Cytoplasmic vesicle	NA	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.	NA	NA	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	2
+NX_P24666	Low molecular weight phosphotyrosine protein phosphatase	158	18042	6.29	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.;Does not possess phosphatase activity.	NA	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	Riboflavin metabolism;Adherens junction	PE1	2
+NX_P24723	Protein kinase C eta type	683	77828	7.94	0	Cytoplasm;Cytosol;Cell membrane	Ischemic stroke	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization.	Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Vascular smooth muscle contraction;Tight junction;Effects of PIP2 hydrolysis;G alpha (z) signalling events	PE1	14
+NX_P24752	Acetyl-CoA acetyltransferase, mitochondrial	427	45200	8.98	0	Mitochondrion	3-ketothiolase deficiency	This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:17371050, PubMed:1715688, PubMed:7728148, PubMed:9744475).	Succinylation at Lys-268, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity).	Belongs to the thiolase-like superfamily. Thiolase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid metabolism;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation;Lysine degradation;Tryptophan metabolism;Pyruvate metabolism;Glyoxylate and dicarboxylate metabolism;Propanoate metabolism;Butanoate metabolism;Terpenoid backbone biosynthesis;Metabolic pathways;Branched-chain amino acid catabolism;Synthesis of Ketone Bodies;Utilization of Ketone Bodies	PE1	11
+NX_P24821	Tenascin	2201	240853	4.79	0	Extracellular matrix	Deafness, autosomal dominant, 56	Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).	NA	Belongs to the tenascin family.	Focal adhesion;ECM-receptor interaction;Syndecan interactions;Integrin cell surface interactions;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	9
+NX_P24844	Myosin regulatory light polypeptide 9	172	19827	4.8	0	NA	NA	Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.	Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge.	NA	Vascular smooth muscle contraction;Focal adhesion;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;EPHA-mediated growth cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate CIT;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	20
+NX_P24855	Deoxyribonuclease-1	282	31434	4.71	0	Endoplasmic reticulum;Nucleus envelope;Secreted;Cytoplasmic vesicle	Systemic lupus erythematosus	Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).	NA	Belongs to the DNase I family.	NA	PE1	16
+NX_P24863	Cyclin-C	283	33243	6.95	0	Nucleoplasm;Cytosol;Nucleus	NA	Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.	NA	Belongs to the cyclin family. Cyclin C subfamily.	Generic Transcription Pathway;PPARA activates gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Transcriptional regulation of white adipocyte differentiation	PE1	6
+NX_P24864	G1/S-specific cyclin-E1	410	47077	5.7	0	Nucleoplasm;Nucleus	NA	Essential for the control of the cell cycle at the G1/S (start) transition.	Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.;Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.	Belongs to the cyclin family. Cyclin E subfamily.	Cell cycle;Oocyte meiosis;p53 signaling pathway;Measles;Pathways in cancer;Prostate cancer;Small cell lung cancer;CDK-mediated phosphorylation and removal of Cdc6;DNA Damage/Telomere Stress Induced Senescence;SCF(Skp2)-mediated degradation of p27/p21;G0 and Early G1;G1/S-Specific Transcription;Association of TriC/CCT with target proteins during biosynthesis;Cyclin E associated events during G1/S transition;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;p53-Dependent G1 DNA Damage Response;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;PTK6 Regulates Cell Cycle	PE1	19
+NX_P24903	Cytochrome P450 2F1	491	55501	6.93	0	Microsome membrane;Endoplasmic reticulum membrane	NA	May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.	NA	Belongs to the cytochrome P450 family.	Metabolism of xenobiotics by cytochrome P450;Xenobiotics;Fatty acids;CYP2E1 reactions	PE1	19
+NX_P24928	DNA-directed RNA polymerase II subunit RPB1	1970	217176	7.02	0	Nucleoplasm;Cytoplasm;Nucleus	NA	(Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.;DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Regulation of gene expression levels depends on the balance between methylation and acetylation levels of tha CTD-lysines (By similarity). Initiation or early elongation steps of transcription of growth-factors-induced immediate early genes are regulated by the acetylation status of the CTD (PubMed:24207025). Methylation and dimethylation have a repressive effect on target genes expression (By similarity).	Among tandem heptapeptide repeats of the C-terminal domain (CTD) some do not match the Y-S-P-T-S-P-S consensus, the seventh serine residue 'Ser-7' being replaced by a lysine. 'Lys-7' in these non-consensus heptapeptide repeats can be alternatively acetylated, methylated and dimethylated. EP300 is one of the enzyme able to acetylate 'Lys-7'. Acetylation at 'Lys-7' of non-consensus heptapeptide repeats is associated with 'Ser-2' phosphorylation and active transcription. Regulates initiation or early elongation steps of transcription specially for inducible genes.;Ubiquitinated by WWP2 leading to proteasomal degradation (By similarity). Following UV treatment, the elongating form of RNA polymerase II (RNA pol IIo) is ubiquitinated on UV damage sites without leading to degradation: ubiquitination is facilitated by KIAA1530/UVSSA and promotes RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery.;The tandem heptapeptide repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II. Phosphorylation occurs mainly at residues 'Ser-2' and 'Ser-5' of the heptapeptide repeat and is mediated, at least, by CDK7 and CDK9. CDK7 phosphorylation of POLR2A associated with DNA promotes transcription initiation by triggering dissociation from DNA. Phosphorylation also takes place at 'Ser-7' of the heptapeptide repeat, which is required for efficient transcription of snRNA genes and processing of the transcripts. The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatases, and a 'CTD code' that specifies the position of Pol II within the transcription cycle has been proposed. Dephosphorylated by the protein phosphatase CTDSP1.;Methylated at Arg-1810 prior to transcription initiation when the CTD is hypophosphorylated, phosphorylation at Ser-1805 and Ser-1808 preventing this methylation. Symmetrically or asymmetrically dimethylated at Arg-1810 by PRMT5 and CARM1 respectively. Symmetric or asymmetric dimethylation modulates interactions with CTD-binding proteins like SMN1/SMN2 and TDRD3. SMN1/SMN2 interacts preferentially with the symmetrically dimethylated form while TDRD3 interacts with the asymmetric form. Through the recruitment of SMN1/SMN2, symmetric dimethylation is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. CTD dimethylation may also facilitate the expression of select RNAs. Among tandem heptapeptide repeats of the C-terminal domain (CTD) some do not match the Y-S-P-T-S-P-S consensus, the seventh serine residue 'Ser-7' being replaced by a lysine. 'Lys-7' in these non-consensus heptapeptide repeats can be alternatively acetylated, methylated, dimethylated and trimethylated. Methylation occurs in the earliest transcription stages and precedes or is concomitant to 'Ser-5' and 'Ser-7' phosphorylation. Dimethylation and trimehtylation at 'Lys-7' of non-consensus heptapeptide repeats are exclusively associated with phosphorylated CTD.;POLR2A is phosphorylated by CDK1;POLR2A is phosphorylated by CDK19;POLR2A is phosphorylated by MAPK3	Belongs to the RNA polymerase beta' chain family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Huntington's disease;Herpes simplex infection;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;MicroRNA (miRNA) biogenesis;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	17
+NX_P24941	Cyclin-dependent kinase 2	298	33930	8.8	0	Cajal body;Cytoplasm;Nucleoplasm;Endosome;Centrosome;Cytosol	NA	Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878).	Phosphorylated at Thr-160 by CDK7 in a CAK complex (PubMed:28666995). Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A.;Nitrosylated after treatment with nitric oxide (DETA-NO).	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Cell cycle;Oocyte meiosis;p53 signaling pathway;Progesterone-mediated oocyte maturation;Measles;Herpes simplex infection;Pathways in cancer;Prostate cancer;Small cell lung cancer;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Factors involved in megakaryocyte development and platelet production;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Meiotic recombination;SCF(Skp2)-mediated degradation of p27/p21;G0 and Early G1;Activation of ATR in response to replication stress;Activation of the pre-replicative complex;Cyclin E associated events during G1/S transition;Cyclin A/B1/B2 associated events during G2/M transition;Regulation of APC/C activators between G1/S and early anaphase;Cyclin A:Cdk2-associated events at S phase entry;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;G2 Phase;p53-Dependent G1 DNA Damage Response;Processing of DNA double-strand break ends;Regulation of TP53 Activity through Phosphorylation;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Degradation;PTK6 Regulates Cell Cycle;Transcriptional regulation of granulopoiesis	PE1	12
+NX_P25021	Histamine H2 receptor	359	40098	9.36	7	Cell membrane	NA	The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Gastric acid secretion;G alpha (s) signalling events;Histamine receptors	PE1	5
+NX_P25024	C-X-C chemokine receptor type 1	350	39791	8.98	7	Cell membrane	NA	Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.	NA	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Endocytosis;Epithelial cell signaling in Helicobacter pylori infection;G alpha (i) signalling events;Chemokine receptors bind chemokines;Neutrophil degranulation	PE1	2
+NX_P25025	C-X-C chemokine receptor type 2	360	40759	8.66	7	Nucleoplasm;Spindle;Cell membrane;Cytoskeleton	NA	Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.	Phosphorylated upon ligand binding; which is required for desensitization.;(Microbial infection) Proteolytically cleaved by Staphylococcus aureus staphopain A/SspP. This cleavage inhibits CXCR2-dependent neutrophil activation and chemotaxis.	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Endocytosis;Epithelial cell signaling in Helicobacter pylori infection;G alpha (i) signalling events;Chemokine receptors bind chemokines;Neutrophil degranulation	PE1	2
+NX_P25054	Adenomatous polyposis coli protein	2843	311646	7.92	0	Cytoplasm;Cell membrane;Adherens junction;Lamellipodium;Ruffle membrane;Cytoskeleton	Hepatocellular carcinoma;Gastric cancer;Hereditary desmoid disease;Medulloblastoma;Familial adenomatous polyposis	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.	Phosphorylated by GSK3B.;Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID.	Belongs to the adenomatous polyposis coli (APC) family.	Wnt signaling pathway;Regulation of actin cytoskeleton;HTLV-I infection;Pathways in cancer;Colorectal cancer;Endometrial cancer;Basal cell carcinoma;Degradation of beta-catenin by the destruction complex;Deactivation of the beta-catenin transactivating complex;Apoptotic cleavage of cellular proteins;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;APC truncation mutants are not K63 polyubiquitinated;Ovarian tumor domain proteases	PE1	5
+NX_P25063	Signal transducer CD24	80	8083	9.69	0	Cell membrane	Multiple sclerosis	May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).	Extensively O-glycosylated.	Belongs to the CD24 family.	Hematopoietic cell lineage;L1CAM interactions	PE1	6
+NX_P25067	Collagen alpha-2(VIII) chain	703	67244	9.05	0	Golgi apparatus;Basement membrane	Corneal dystrophy, posterior polymorphous, 2;Corneal dystrophy, Fuchs endothelial, 1	Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity).	Proteolytically cleaved by neutrophil elastase, in vitro.;Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	NA	Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	1
+NX_P25089	N-formyl peptide receptor 3	353	39965	8.12	7	Cell membrane	NA	Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Staphylococcus aureus infection;G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands	PE1	19
+NX_P25090	N-formyl peptide receptor 2	351	38964	8.09	7	Cell membrane	NA	Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Staphylococcus aureus infection;G alpha (i) signalling events;G alpha (q) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands;Neutrophil degranulation	PE1	19
+NX_P25092	Heat-stable enterotoxin receptor	1073	123403	6.77	1	Cytoplasmic vesicle;Endoplasmic reticulum membrane;Cell membrane	Meconium ileus;Diarrhea 6	Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin.	Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GC-C activation.	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Digestion;Intestinal infectious diseases	PE1	12
+NX_P25098	Beta-adrenergic receptor kinase 1	689	79574	6.89	0	Cytoplasmic vesicle;Cytoplasm;Cell membrane	NA	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Chemokine signaling pathway;Endocytosis;Glutamatergic synapse;G alpha (q) signalling events;G alpha (s) signalling events;Activation of SMO;Calmodulin induced events;Cargo recognition for clathrin-mediated endocytosis	PE1	11
+NX_P25100	Alpha-1D adrenergic receptor	572	60463	9.41	7	Cell membrane	NA	This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.	NA	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;Salivary secretion;G alpha (q) signalling events;G alpha (12/13) signalling events;Adrenoceptors	PE1	20
+NX_P25101	Endothelin-1 receptor	427	48722	8.73	7	Cytosol;Cell membrane	Mandibulofacial dysostosis with alopecia	Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.	EDNRA is phosphorylated by GRK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	4
+NX_P25103	Substance-P receptor	407	46251	6.78	7	Cell membrane	NA	This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.	TACR1 is phosphorylated by GRK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Measles;G alpha (q) signalling events;Tachykinin receptors bind tachykinins;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	2
+NX_P25105	Platelet-activating factor receptor	342	39203	9.2	7	Cytoplasmic vesicle;Nucleoplasm;Cell membrane	NA	Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Staphylococcus aureus infection;G alpha (q) signalling events;Class A/1 (Rhodopsin-like receptors);Interferon gamma signaling;Neutrophil degranulation;Interleukin-10 signaling	PE1	1
+NX_P25106	Atypical chemokine receptor 3	362	41493	7.52	7	Cell membrane;Recycling endosome;Early endosome;Cytoplasmic vesicle;Perinuclear region	NA	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.	The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.;Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner.	Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.	Cytokine-cytokine receptor interaction;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	2
+NX_P25116	Proteinase-activated receptor 1	425	47441	8.62	7	Cell membrane	NA	High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.	A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.;Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor.	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Endocytosis;Complement and coagulation cascades;Regulation of actin cytoskeleton;Peptide ligand-binding receptors;G alpha (q) signalling events;Common Pathway of Fibrin Clot Formation;Thrombin signalling through proteinase activated receptors (PARs)	PE1	5
+NX_P25189	Myelin protein P0	248	27555	9.57	1	Myelin membrane;Cell membrane	Dejerine-Sottas syndrome;Charcot-Marie-Tooth disease, dominant, intermediate type, D;Charcot-Marie-Tooth disease 1B;Neuropathy, congenital hypomyelinating, 2;Charcot-Marie-Tooth disease 2J;Roussy-Levy syndrome;Charcot-Marie-Tooth disease 2I;Adie pupil	Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.	N-glycosylated; contains sulfate-substituted glycan.	Belongs to the myelin P0 protein family.	Cell adhesion molecules (CAMs)	PE1	1
+NX_P25205	DNA replication licensing factor MCM3	808	90981	5.53	0	Nucleoplasm;Nucleus	NA	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.	Acetylated by MCM3AP.;O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.	Belongs to the MCM family.	DNA replication;Cell cycle;Orc1 removal from chromatin;Activation of ATR in response to replication stress;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;Unwinding of DNA;Switching of origins to a post-replicative state	PE1	6
+NX_P25208	Nuclear transcription factor Y subunit beta	207	22831	4.46	0	Nucleoplasm;Nucleus	NA	Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.	Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'.	Belongs to the NFYB/HAP3 subunit family.	Antigen processing and presentation;Tuberculosis;HTLV-I infection;PPARA activates gene expression;ATF4 activates genes in response to endoplasmic reticulum stress;Activation of gene expression by SREBF (SREBP);ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes	PE1	12
+NX_P25311	Zinc-alpha-2-glycoprotein	298	34259	5.71	0	Secreted	NA	Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.	N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.	Belongs to the MHC class I family.	Miscellaneous transport and binding events	PE1	7
+NX_P25325	3-mercaptopyruvate sulfurtransferase	297	33178	6.13	0	Cytoplasm;Cytosol;Mitochondrion;Synaptosome	NA	Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions.	NA	NA	Cysteine and methionine metabolism;Metabolic pathways;Sulfur relay system;Degradation of cysteine and homocysteine	PE1	22
+NX_P25391	Laminin subunit alpha-1	3075	337084	5.93	0	Basement membrane	Poretti-Boltshauser syndrome	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	Tyrosine phosphorylated by PKDCC/VLK.	NA	Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer;ECM proteoglycans;Non-integrin membrane-ECM interactions;L1CAM interactions;Laminin interactions;MET activates PTK2 signaling	PE1	18
+NX_P25398	40S ribosomal protein S12	132	14515	6.81	0	Golgi apparatus;Cytoplasm;Nucleolus;Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eS12 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	6
+NX_P25440	Bromodomain-containing protein 2	801	88061	9.13	0	Nucleus speckle;Nucleus	NA	May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.	NA	NA	RUNX3 regulates p14-ARF	PE1	6
+NX_P25445	Tumor necrosis factor receptor superfamily member 6	335	37732	8.29	1	Cytosol;Secreted;Nucleus;Cell membrane	Autoimmune lymphoproliferative syndrome 1A	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).	N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.;FAS is phosphorylated by EGFR (Phosphotyrosine:PTM-0255)	NA	MAPK signaling pathway;Cytokine-cytokine receptor interaction;p53 signaling pathway;Apoptosis;Natural killer cell mediated cytotoxicity;Type I diabetes mellitus;Alzheimer's disease;Chagas disease (American trypanosomiasis);African trypanosomiasis;Measles;Influenza A;Herpes simplex infection;Pathways in cancer;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;Caspase activation via Death Receptors in the presence of ligand;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;FasL/ CD95L signaling;TP53 Regulates Transcription of Death Receptors and Ligands	PE1	10
+NX_P25490	Transcriptional repressor protein YY1	414	44713	5.8	0	Nucleus matrix;Nucleolus;Nucleoplasm;Cytoplasmic vesicle;Nucleus	Gabriele-de Vries syndrome	Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.;Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647).	Ubiquitinated.;Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites.	Belongs to the YY transcription factor family.	DNA Damage Recognition in GG-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;UCH proteinases;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;Estrogen-dependent gene expression	PE1	14
+NX_P25685	DnaJ homolog subfamily B member 1	340	38044	8.74	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).	NA	NA	Protein processing in endoplasmic reticulum;Influenza A;MAPK6/MAPK4 signaling;Regulation of HSF1-mediated heat shock response;Attenuation phase;HSF1-dependent transactivation;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	19
+NX_P25686	DnaJ homolog subfamily B member 2	324	35580	5.69	0	Cytoplasm;Endoplasmic reticulum membrane;Nucleus membrane;Nucleus	Distal spinal muscular atrophy, autosomal recessive, 5	Which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278).;Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695).	Ubiquitinated by STUB1; does not lead to proteasomal degradation.	NA	Protein processing in endoplasmic reticulum	PE1	2
+NX_P25705	ATP synthase subunit alpha, mitochondrial	553	59751	9.16	0	Mitochondrion inner membrane;Mitochondrion;Cell membrane	Mitochondrial complex V deficiency, nuclear type 4;Combined oxidative phosphorylation deficiency 22	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159).	The N-terminus is blocked.;Acetylated on lysine residues. BLOC1S1 is required for acetylation.	Belongs to the ATPase alpha/beta chains family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Mitochondrial protein import;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	18
+NX_P25713	Metallothionein-3	68	6927	4.79	0	NA	NA	Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.	NA	Belongs to the metallothionein superfamily. Type 1 family.	Metallothioneins bind metals	PE1	16
+NX_P25774	Cathepsin S	331	37496	8.61	0	Cytoplasmic vesicle;Lysosome	NA	Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.	NA	Belongs to the peptidase C1 family.	Lysosome;Phagosome;Antigen processing and presentation;Tuberculosis;Degradation of the extracellular matrix;MHC class II antigen presentation;Endosomal/Vacuolar pathway;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;Neutrophil degranulation	PE1	1
+NX_P25786	Proteasome subunit alpha type-1	263	29556	6.15	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).	NA	Belongs to the peptidase T1A family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	11
+NX_P25787	Proteasome subunit alpha type-2	234	25899	6.91	0	Cytoplasm;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).	Phosphorylated on tyrosine residues; which may be important for nuclear import.	Belongs to the peptidase T1A family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	7
+NX_P25788	Proteasome subunit alpha type-3	255	28433	5.19	0	Cytoplasm;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.	NA	Belongs to the peptidase T1A family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	14
+NX_P25789	Proteasome subunit alpha type-4	261	29484	7.58	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).	NA	Belongs to the peptidase T1A family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	15
+NX_P25791	Rhombotin-2	158	18358	6.79	0	Nucleoplasm;Nucleus	NA	Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.	NA	NA	RUNX1 regulates transcription of genes involved in differentiation of HSCs	PE1	11
+NX_P25800	Rhombotin-1	156	17828	8.33	0	Nucleus	NA	May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.	NA	NA	RUNX1 regulates transcription of genes involved in differentiation of HSCs	PE1	11
+NX_P25815	Protein S100-P	95	10400	4.75	0	Cytoplasm;Microvillus membrane;Nucleus	NA	May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).	NA	Belongs to the S-100 family.	Neutrophil degranulation	PE1	4
+NX_P25874	Mitochondrial brown fat uncoupling protein 1	307	33005	9.26	6	Mitochondrion inner membrane	NA	Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).	May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.;May undergo ubiquitin-mediated proteasomal degradation.	Belongs to the mitochondrial carrier (TC 2.A.29) family.	PPAR signaling pathway;Huntington's disease;The fatty acid cycling model;The proton buffering model	PE1	4
+NX_P25929	Neuropeptide Y receptor type 1	384	44392	7.94	7	Nucleoplasm;Cytosol;Mitochondrion;Cell membrane	NA	Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	4
+NX_P25940	Collagen alpha-3(V) chain	1745	172121	6.44	0	Extracellular matrix	NA	Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the fibrillar collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Syndecan interactions;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Non-integrin membrane-ECM interactions;Extracellular matrix organization;MET activates PTK2 signaling;Collagen chain trimerization	PE1	19
+NX_P25942	Tumor necrosis factor receptor superfamily member 5	277	30619	5.49	1	Secreted;Cell membrane	Immunodeficiency with hyper-IgM 3	Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.	NA	NA	Cytokine-cytokine receptor interaction;Cell adhesion molecules (CAMs);Toll-like receptor signaling pathway;Intestinal immune network for IgA production;Malaria;Toxoplasmosis;HTLV-I infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Allograft rejection;Primary immunodeficiency;Viral myocarditis;TNFR2 non-canonical NF-kB pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	PE1	20
+NX_P25963	NF-kappa-B inhibitor alpha	317	35609	4.57	0	Cytoplasm;Cytosol;Nucleus	Ectodermal dysplasia and immunodeficiency 2	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.	Phosphorylated; disables inhibition of NF-kappa-B DNA-binding activity. Phosphorylation at positions 32 and 36 is prerequisite to recognition by UBE2D3 leading to polyubiquitination and subsequent degradation.;Sumoylated; sumoylation requires the presence of the nuclear import signal. Sumoylation blocks ubiquitination and proteasome-mediated degradation of the protein thereby increasing the protein stability.;Deubiquitinated by porcine reproductive and respiratory syndrome virus Nsp2 protein, which thereby interferes with NFKBIA degradation and impairs subsequent NF-kappa-B activation.;Monoubiquitinated at Lys-21 and/or Lys-22 by UBE2D3. Ubiquitin chain elongation is then performed by CDC34 in cooperation with the SCF(FBXW11) E3 ligase complex, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. The resulting polyubiquitination leads to protein degradation. Also ubiquitinated by SCF(BTRC) following stimulus-dependent phosphorylation at Ser-32 and Ser-36.;NFKBIA is phosphorylated by TBK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the NF-kappa-B inhibitor family.	Chemokine signaling pathway;Apoptosis;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Neurotrophin signaling pathway;Adipocytokine signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Herpes simplex infection;Pathways in cancer;Prostate cancer;Chronic myeloid leukemia;Small cell lung cancer;Activation of NF-kappaB in B cells;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Downstream TCR signaling;RIP-mediated NFkB activation via ZBP1;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;IkBA variant leads to EDA-ID;NF-kB is activated and signals survival;Ub-specific processing proteases;Interleukin-1 signaling;SUMOylation of immune response proteins	PE1	14
+NX_P26006	Integrin alpha-3	1051	116612	6.32	1	Invadopodium membrane;Filopodium membrane;Cell membrane	Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital	Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.	But not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation.	Belongs to the integrin alpha chain family.	Focal adhesion;ECM-receptor interaction;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Pathways in cancer;Small cell lung cancer;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Integrin cell surface interactions;Basigin interactions;Laminin interactions;MET activates PTK2 signaling	PE1	17
+NX_P26010	Integrin beta-7	798	86903	5.67	1	Membrane;Cytosol;Cell membrane	NA	Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.	NA	Belongs to the integrin beta chain family.	Focal adhesion;ECM-receptor interaction;Cell adhesion molecules (CAMs);Intestinal immune network for IgA production;Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions	PE1	12
+NX_P26012	Integrin beta-8	769	85632	7.06	1	Cytosol;Cell membrane	NA	Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072). It recognizes the sequence R-G-D in its ligands (PubMed:1918072). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity).	NA	Belongs to the integrin beta chain family.	Focal adhesion;ECM-receptor interaction;Cell adhesion molecules (CAMs);Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Integrin cell surface interactions;Molecules associated with elastic fibres	PE1	7
+NX_P26022	Pentraxin-related protein PTX3	381	41976	4.94	0	Secreted;Cell membrane	NA	Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.	Glycosylated.	NA	Neutrophil degranulation	PE1	3
+NX_P26038	Moesin	577	67820	6.08	0	Cell membrane;Microvillus membrane;Apical cell membrane;Microvillus;Cytoskeleton	Immunodeficiency 50	Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation (PubMed:27405666).	S-nitrosylation of Cys-117 is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) implicating the iNOS-S100A8/9 transnitrosylase complex.;Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization.	NA	Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Measles;Recycling pathway of L1;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	X
+NX_P26045	Tyrosine-protein phosphatase non-receptor type 3	913	103990	6.58	0	Cell membrane;Cytoskeleton	NA	May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.	EGFR downregulation	PE1	9
+NX_P26196	Probable ATP-dependent RNA helicase DDX6	483	54417	8.85	0	Cytoplasm;Cytosol;P-body;Nucleus	NA	In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).	Sumoylated (PubMed:26184334).	Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.	RNA degradation;mRNA decay by 5' to 3' exoribonuclease	PE1	11
+NX_P26232	Catenin alpha-2	953	105313	5.52	0	Cytoplasm;Cell membrane;Adherens junction;Axon;Nucleus;Cytoskeleton	Cortical dysplasia, complex, with other brain malformations 9	May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).	NA	Belongs to the vinculin/alpha-catenin family.	Adherens junction;Tight junction;Leukocyte transendothelial migration;Bacterial invasion of epithelial cells;Pathways in cancer;Endometrial cancer;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Myogenesis	PE1	2
+NX_P26358	DNA (cytosine-5)-methyltransferase 1	1616	183165	7.99	0	Nucleoplasm;Nucleus	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant;Neuropathy, hereditary sensory, 1E	Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306).	Methylation at Lys-142 by SETD7 promotes DNMT1 proteasomal degradation.;Acetylation on multiple lysines, mainly by KAT2B/PCAF, regulates cell cycle G(2)/M transition. Deacetylation of Lys-1349 and Lys-1415 by SIRT1 increases methyltransferase activity.;Phosphorylation of Ser-154 by CDKs is important for enzymatic activity and protein stability. Phosphorylation of Ser-143 by AKT1 prevents methylation by SETD7 therebye increasing DNMT1 stability.;Sumoylated; sumoylation increases activity.;Ubiquitinated by UHRF1; interaction with USP7 counteracts ubiquitination by UHRF1 by promoting deubiquitination and preventing degradation by the proteasome.;DNMT1 is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);DNMT1 is phosphorylated by CDKL5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Cysteine and methionine metabolism;Metabolic pathways;NoRC negatively regulates rRNA expression;PRC2 methylates histones and DNA;DNA methylation;SUMOylation of DNA methylation proteins	PE1	19
+NX_P26367	Paired box protein Pax-6	422	46683	9.45	0	Nucleoplasm;Nucleus	Aniridia 2;Coloboma of optic nerve;Anterior segment dysgenesis 5;Keratitis hereditary;Aniridia 1;Bilateral optic nerve hypoplasia;Coloboma, ocular, autosomal dominant;Foveal hypoplasia 1	Appears to function as a molecular switch that specifies target genes.;Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).	Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation.	Belongs to the paired homeobox family.	Maturity onset diabetes of the young;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);Regulation of gene expression in beta cells;Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	11
+NX_P26368	Splicing factor U2AF 65 kDa subunit	475	53501	9.19	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186).	Lysyl-hydroxylation at Lys-15 and Lys-276 affects the mRNA splicing activity of the protein, leading to regulate some, but not all, alternative splicing events.;U2AF2 is phosphorylated by SRPK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the splicing factor SR family.	Spliceosome;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	19
+NX_P26371	Keratin-associated protein 5-9	169	16276	8.34	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 5 family.	Keratinization	PE1	11
+NX_P26373	60S ribosomal protein L13	211	24261	11.65	0	Endoplasmic reticulum;Cytoplasm;Cytosol;Nucleolus	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL13 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	16
+NX_P26374	Rab proteins geranylgeranyltransferase component A 2	656	74071	4.84	0	Nucleoplasm;Cytosol	NA	Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.	NA	Belongs to the Rab GDI family.	RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	1
+NX_P26378	ELAV-like protein 4	385	42398	9.44	0	Cytoplasm;Perikaryon;Growth cone;Nucleoplasm;Cytoplasmic vesicle;Axon;Dendrite	NA	RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636).	Methylated by CARM1, which leads to reduced RNA-binding activity and enhanced interaction with SMN (PubMed:21088113). Methylation at Arg-248 by CARM1 weakens protective binding to the 3'UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state (By similarity). Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).	Belongs to the RRM elav family.	NA	PE1	1
+NX_P26436	Acrosomal protein SP-10	265	28156	4.68	0	Acrosome	NA	NA	NA	NA	NA	PE1	11
+NX_P26439	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2	372	42052	8.12	1	Mitochondrion membrane;Endoplasmic reticulum membrane	Adrenal hyperplasia 2	3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.	NA	Belongs to the 3-beta-HSD family.	Lipid metabolism; steroid biosynthesis.;Steroid hormone biosynthesis;Metabolic pathways;Glucocorticoid biosynthesis;Androgen biosynthesis;Mineralocorticoid biosynthesis	PE1	1
+NX_P26440	Isovaleryl-CoA dehydrogenase, mitochondrial	426	46651	8.27	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	Isovaleric acidemia	NA	NA	Belongs to the acyl-CoA dehydrogenase family.	Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.;Valine, leucine and isoleucine degradation;Metabolic pathways;Branched-chain amino acid catabolism	PE1	15
+NX_P26441	Ciliary neurotrophic factor	200	22931	6.35	0	Cytoplasmic vesicle;Cytoplasm	NA	CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.	NA	Belongs to the CNTF family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;IL-6-type cytokine receptor ligand interactions	PE1	11
+NX_P26447	Protein S100-A4	101	11729	5.85	0	Cell membrane	NA	NA	NA	Belongs to the S-100 family.	NA	PE1	1
+NX_P26572	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	445	50878	9.25	1	Golgi apparatus membrane	NA	Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.	NA	Belongs to the glycosyltransferase 13 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;N-glycan trimming and elongation in the cis-Golgi	PE1	5
+NX_P26583	High mobility group protein B2	209	24034	7.62	0	Cytoplasm;Secreted;Nucleolus;Chromosome;Nucleoplasm;Nucleus	NA	Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).	Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so).;Acetylation enhances nucleosome binding and chromation remodeling activity.	Belongs to the HMGB family.	Apoptosis induced DNA fragmentation	PE1	4
+NX_P26599	Polypyrimidine tract-binding protein 1	531	57221	9.22	0	Nucleoplasm;Nucleus	NA	Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806).	NA	NA	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;FGFR2 alternative splicing	PE1	19
+NX_P26639	Threonine--tRNA ligase 1, cytoplasmic	723	83435	6.23	0	Cytoplasm;Cytosol;Cytoskeleton	NA	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity).	ISGylated.	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation	PE1	5
+NX_P26640	Valine--tRNA ligase	1264	140476	7.53	0	Cytosol	Neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy	NA	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation	PE1	6
+NX_P26641	Elongation factor 1-gamma	437	50119	6.25	0	Cytoplasm;Mitochondrion	NA	Probably plays a role in anchoring the complex to other cellular components.	NA	NA	Legionellosis;Eukaryotic Translation Elongation	PE1	11
+NX_P26651	mRNA decay activator protein ZFP36	326	34003	8.86	0	Cytoplasm;P-body;Cytoplasmic granule;Nucleus;Cytoskeleton	NA	Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:9703499, PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:27193233, PubMed:23644599, PubMed:25815583). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:19188452, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077).;(Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter.	Phosphorylated. Phosphorylation at serine and/or threonine residues occurs in a p38 MAPK- and MAPKAPK2-dependent manner (PubMed:16702957). Phosphorylated by MAPKAPK2 at Ser-60 and Ser-186; phosphorylation increases its stability and cytoplasmic localization, promotes binding to 14-3-3 adapter proteins and inhibits the recruitment of cytoplasmic CCR4-NOT and PAN2-PAN3 deadenylase complexes to the mRNA decay machinery, thereby inhibiting ZFP36-induced ARE-containing mRNA deadenylation and decay processes. Phosphorylation by MAPKAPK2 does not impair ARE-containing RNA-binding. Phosphorylated in a MAPKAPK2- and p38 MAPK-dependent manner upon skeletal muscle satellite cell activation; this phosphorylation inhibits ZFP36-mediated mRNA decay activity, and hence stabilizes MYOD1 mRNA (By similarity). Phosphorylated by MAPK1 upon mitogen stimulation (By similarity). Phosphorylated at Ser-66 and Ser-93; these phosphorylations increase in a SH3KBP1-dependent manner (PubMed:20221403). Phosphorylated at serine and threonine residues in a pyruvate kinase PKM- and p38 MAPK-dependent manner (PubMed:26926077). Phosphorylation at Ser-60 may participate in the PKM-mediated degradation of ZFP36 in a p38 MAPK-dependent manner (PubMed:26926077). Dephosphorylated by serine/threonine phosphatase 2A at Ser-186 (By similarity).;Ubiquitinated; pyruvate kinase (PKM)-dependent ubiquitination leads to proteasomal degradation through a p38 MAPK signaling pathway (PubMed:26926077).	NA	HTLV-I infection;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	PE1	19
+NX_P26678	Cardiac phospholamban	52	6109	9.5	1	Mitochondrion membrane;Membrane;Endoplasmic reticulum membrane;Sarcoplasmic reticulum membrane	Cardiomyopathy, dilated 1P;Cardiomyopathy, familial hypertrophic 18	Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.	Palmitoylated by ZDHHC16, promoting formation of the homopentamer.;Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.	Belongs to the phospholamban family.	Calcium signaling pathway;Dilated cardiomyopathy;Ion transport by P-type ATPases;Ion homeostasis	PE1	6
+NX_P26715	NKG2-A/NKG2-B type II integral membrane protein	233	26314	8.53	1	Membrane	NA	Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	NA	NA	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Graft-versus-host disease;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	12
+NX_P26717	NKG2-C type II integral membrane protein	231	26072	8.69	1	Membrane	NA	Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	NA	NA	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;DAP12 signaling;DAP12 interactions	PE1	12
+NX_P26718	NKG2-D type II integral membrane protein	216	25274	8.56	1	Cell membrane	NA	Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.	NA	NA	Natural killer cell mediated cytotoxicity;Malaria;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 signaling;DAP12 interactions	PE1	12
+NX_P26842	CD27 antigen	260	29137	7.8	1	Membrane	Lymphoproliferative syndrome 2	Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.	O-glycosylated with core 1 or possibly core 8 glycans.;Phosphorylated.	NA	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	12
+NX_P26885	Peptidyl-prolyl cis-trans isomerase FKBP2	142	15649	9.24	0	Endoplasmic reticulum membrane;Cell membrane	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.	NA	Belongs to the FKBP-type PPIase family. FKBP2 subfamily.	NA	PE1	11
+NX_P26927	Hepatocyte growth factor-like protein	711	80320	7.98	0	Secreted	NA	NA	Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains.	Belongs to the peptidase S1 family. Plasminogen subfamily.	Signaling by MST1	PE1	3
+NX_P26951	Interleukin-3 receptor subunit alpha	378	43330	8.6	1	Membrane;Cell membrane	NA	This is a receptor for interleukin-3.	NA	Belongs to the type I cytokine receptor family. Type 5 subfamily.	Cytokine-cytokine receptor interaction;Apoptosis;Jak-STAT signaling pathway;Hematopoietic cell lineage;RAF/MAP kinase cascade;Interleukin receptor SHC signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling	PE1	X
+NX_P26992	Ciliary neurotrophic factor receptor subunit alpha	372	40633	6.26	0	Cell membrane	NA	Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303).	NA	Belongs to the type I cytokine receptor family. Type 3 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;IL-6-type cytokine receptor ligand interactions	PE1	9
+NX_P26998	Beta-crystallin B3	211	24252	6.25	0	NA	Cataract 22, multiple types	Crystallins are the dominant structural components of the vertebrate eye lens.	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	22
+NX_P27037	Activin receptor type-2A	513	57848	5.61	1	Membrane;Cytosol	NA	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).	NA	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Signaling by BMP;Signaling by NODAL;Signaling by Activin;Regulation of signaling by NODAL	PE1	2
+NX_P27105	Erythrocyte band 7 integral membrane protein	288	31731	7.71	0	Cell membrane;Melanosome;Cytoplasmic vesicle;Cytosol;Membrane raft;Cytoskeleton	NA	Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.	NA	Belongs to the band 7/mec-2 family.	Stimuli-sensing channels;Neutrophil degranulation	PE1	9
+NX_P27144	Adenylate kinase 4, mitochondrial	223	25268	8.47	0	Mitochondrion matrix;Mitochondrion	NA	Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (PubMed:19073142, PubMed:19766732, PubMed:23416111). Also displays broad nucleoside diphosphate kinase activity (PubMed:19073142, PubMed:19766732, PubMed:23416111). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (PubMed:24767988, PubMed:26980435). Plays a protective role in the cellular response to oxidative stress (PubMed:19130895, PubMed:23474458, PubMed:26980435).	NA	Belongs to the adenylate kinase family. AK3 subfamily.	Purine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	1
+NX_P27169	Serum paraoxonase/arylesterase 1	355	39731	5.08	0	Extracellular space	Microvascular complications of diabetes 5	Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.	Glycosylated.;The signal sequence is not cleaved.;Present in two forms, form B contains a disulfide bond, form A does not.	Belongs to the paraoxonase family.	Metabolic pathways;Synthesis of 5-eicosatetraenoic acids	PE1	7
+NX_P27216	Annexin A13	316	35415	5.47	0	Cytoplasmic vesicle;Nucleoplasm;Apical cell membrane;Cell membrane	NA	Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed:27676605, PubMed:30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed:27676605).;Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.	NA	Belongs to the annexin family.	NA	PE1	8
+NX_P27338	Amine oxidase [flavin-containing] B	520	58763	7.2	1	Mitochondrion outer membrane	NA	Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.	NA	Belongs to the flavin monoamine oxidase family.	Glycine, serine and threonine metabolism;Arginine and proline metabolism;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;Tryptophan metabolism;Drug metabolism - cytochrome P450;Metabolic pathways;Dopaminergic synapse;Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	PE1	X
+NX_P27348	14-3-3 protein theta	245	27764	4.68	0	Cytoplasm	NA	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.	Ser-232 is probably phosphorylated by CK1.	Belongs to the 14-3-3 family.	Cell cycle;Oocyte meiosis;Neurotrophin signaling pathway;Pathogenic Escherichia coli infection;Translocation of SLC2A4 (GLUT4) to the plasma membrane;TP53 Regulates Metabolic Genes;Activation of BAD and translocation to mitochondria;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;RHO GTPases activate PKNs;Regulation of localization of FOXO transcription factors	PE1	2
+NX_P27352	Cobalamin binding intrinsic factor	417	45416	5.8	0	Secreted	Hereditary intrinsic factor deficiency	Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.	NA	Belongs to the eukaryotic cobalamin transport proteins family.	Vitamin digestion and absorption;Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective AMN causes hereditary megaloblastic anemia 1;Defective CUBN causes hereditary megaloblastic anemia 1;Defective GIF causes intrinsic factor deficiency	PE1	11
+NX_P27361	Mitogen-activated protein kinase 3	379	43136	6.28	0	Cytoplasm;Nucleoplasm;Caveola;Nucleus	NA	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.	Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Oocyte meiosis;mTOR signaling pathway;Vascular smooth muscle contraction;Dorso-ventral axis formation;TGF-beta signaling pathway;Axon guidance;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Adherens junction;Gap junction;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Long-term potentiation;Neurotrophin signaling pathway;Glutamatergic synapse;Cholinergic synapse;Long-term depression;Regulation of actin cytoskeleton;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Alzheimer's disease;Prion diseases;Shigellosis;Salmonella infection;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Hepatitis C;Influenza A;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Thyroid cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;ISG15 antiviral mechanism;Regulation of HSF1-mediated heat shock response;RAF/MAP kinase cascade;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;Signal transduction by L1;Advanced glycosylation endproduct receptor signaling;Senescence-Associated Secretory Phenotype (SASP);RNA Polymerase I Promoter Opening;RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway;MAP2K and MAPK activation;Growth hormone receptor signaling;Thrombin signalling through proteinase activated receptors (PARs);Oncogene Induced Senescence;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK;NCAM signaling for neurite out-growth;MAPK3 (ERK1) activation;Golgi Cisternae Pericentriolar Stack Reorganization;Signal attenuation;Spry regulation of FGF signaling;RHO GTPases Activate NADPH Oxidases;ERK/MAPK targets;Activation of the AP-1 family of transcription factors;ERKs are inactivated;Frs2-mediated activation;Negative feedback regulation of MAPK pathway;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Regulation of PTEN gene transcription;RUNX2 regulates osteoblast differentiation;ESR-mediated signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling;Regulation of the apoptosome activity	PE1	16
+NX_P27448	MAP/microtubule affinity-regulating kinase 3	753	84429	9.59	0	Cytoplasm;Dendrite;Cell membrane	Visual impairment and progressive phthisis bulbi	Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).	Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity.;MARK3 is phosphorylated by PIM1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	Negative regulation of MAPK pathway;RAF activation;MAP2K and MAPK activation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	14
+NX_P27449	V-type proton ATPase 16 kDa proteolipid subunit	155	15736	7.98	4	Vacuole membrane;Cytosol	NA	Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway.	Belongs to the V-ATPase proteolipid subunit family.	Oxidative phosphorylation;Metabolic pathways;Lysosome;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Tuberculosis;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport;Neutrophil degranulation	PE1	16
+NX_P27469	G0/G1 switch protein 2	103	11321	9.73	0	Mitochondrion	NA	Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.	NA	NA	PPARA activates gene expression	PE1	1
+NX_P27482	Calmodulin-like protein 3	149	16891	4.3	0	NA	NA	May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.	NA	Belongs to the calmodulin family.	Calcium signaling pathway;Phosphatidylinositol signaling system;Oocyte meiosis;Vascular smooth muscle contraction;Long-term potentiation;Neurotrophin signaling pathway;Dopaminergic synapse;Olfactory transduction;Phototransduction;Insulin signaling pathway;GnRH signaling pathway;Melanogenesis;Salivary secretion;Gastric acid secretion;Alzheimer's disease;Pertussis;Tuberculosis;Glioma	PE1	10
+NX_P27487	Dipeptidyl peptidase 4	766	88279	5.67	1	Cell membrane;Cell junction;Secreted;Lamellipodium membrane;Invadopodium membrane;Apical cell membrane;Membrane raft	NA	Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.	N- and O-Glycosylated.;The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.;Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation.	Belongs to the peptidase S9B family. DPPIV subfamily.	Protein digestion and absorption;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	PE1	2
+NX_P27539	Embryonic growth/differentiation factor 1	372	39475	9.51	0	Secreted	Congenital heart defects, multiple types, 6;Conotruncal heart malformations;Right atrial isomerism;Tetralogy of Fallot	May mediate cell differentiation events during embryonic development.	NA	Belongs to the TGF-beta family.	Signaling by NODAL	PE1	19
+NX_P27540	Aryl hydrocarbon receptor nuclear translocator	789	86636	6.11	0	Nucleoplasm;Nucleus	NA	Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).	NA	NA	Pathways in cancer;Renal cell carcinoma;Xenobiotics;PPARA activates gene expression;Regulation of gene expression by Hypoxia-inducible Factor;Endogenous sterols;Phase I - Functionalization of compounds;Aryl hydrocarbon receptor signalling	PE1	1
+NX_P27544	Ceramide synthase 1	350	39536	9.17	6	Endoplasmic reticulum;Endoplasmic reticulum membrane	Epilepsy, progressive myoclonic 8	Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA).	Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation.	NA	Lipid metabolism; sphingolipid metabolism.;Sphingolipid de novo biosynthesis	PE1	19
+NX_P27635	60S ribosomal protein L10	214	24604	10.11	0	Nucleus	Autism, X-linked 5;Mental retardation, X-linked, syndromic, 35	Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788).	Citrullinated by PADI4.;RPL10 is phosphorylated by YES1	Belongs to the universal ribosomal protein uL16 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	X
+NX_P27658	Collagen alpha-1(VIII) chain	744	73364	9.62	0	Cytoplasmic vesicle;Basement membrane	NA	Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.;Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.	Proteolytically cleaved by neutrophil elastase, in vitro. Proteolytic processing produces the C-terminal NC1 domain fragment, vastatin.;Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	NA	Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	3
+NX_P27694	Replication protein A 70 kDa DNA-binding subunit	616	68138	6.92	0	Nucleoplasm;PML body;Nucleus	NA	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:27723720, PubMed:27723717). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance (PubMed:17959650). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).	DNA damage-induced 'Lys-63'-linked polyubiquitination by PRPF19 mediates ATRIP recruitment to the RPA complex at sites of DNA damage and activation of ATR (PubMed:24332808). Ubiquitinated by RFWD3 at stalled replication forks in response to DNA damage: ubiquitination by RFWD3 does not lead to degradation by the proteasome and promotes removal of the RPA complex from stalled replication forks, promoting homologous recombination (PubMed:26474068).;Sumoylated on lysine residues Lys-449 and Lys-577, with Lys-449 being the major site. Sumoylation promotes recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Desumoylated by SENP6.	Belongs to the replication factor A protein 1 family.	DNA replication;Nucleotide excision repair;Mismatch repair;Homologous recombination;Fanconi anemia pathway;SUMOylation of DNA damage response and repair proteins;Regulation of HSF1-mediated heat shock response;Translesion Synthesis by POLH;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Meiotic recombination;Activation of ATR in response to replication stress;Activation of the pre-replicative complex;G2/M DNA damage checkpoint;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Removal of the Flap Intermediate from the C-strand;Removal of the Flap Intermediate;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation	PE1	17
+NX_P27695	DNA-(apurinic or apyrimidinic site) lyase	318	35555	8.33	0	Cytoplasm;Mitochondrion;Nucleus speckle;Nucleolus;Endoplasmic reticulum;Nucleoplasm;Nucleus	NA	Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA.	Cleaved at Lys-31 by granzyme A to create the mitochondrial form; leading in reduction of binding to DNA, AP endodeoxynuclease activity, redox activation of transcription factors and to enhanced cell death. Cleaved by granzyme K; leading to intracellular ROS accumulation and enhanced cell death after oxidative stress.;Phosphorylated. Phosphorylation by kinase PKC or casein kinase CK2 results in enhanced redox activity that stimulates binding of the FOS/JUN AP-1 complex to its cognate binding site. AP-endodeoxyribonuclease activity is not affected by CK2-mediated phosphorylation. Phosphorylation of Thr-233 by CDK5 reduces AP-endodeoxyribonuclease activity resulting in accumulation of DNA damage and contributing to neuronal death.;Acetylated on Lys-6 and Lys-7. Acetylation is increased by the transcriptional coactivator EP300 acetyltransferase, genotoxic agents like H(2)O(2) and methyl methanesulfonate (MMS). Acetylation increases its binding affinity to the negative calcium response element (nCaRE) DNA promoter. The acetylated form induces a stronger binding of YBX1 to the Y-box sequence in the MDR1 promoter than the unacetylated form. Deacetylated on lysines. Lys-6 and Lys-7 are deacetylated by SIRT1.;Ubiquitinated by MDM2; leading to translocation to the cytoplasm and proteasomal degradation.;Cys-65 and Cys-93 are nitrosylated in response to nitric oxide (NO) and lead to the exposure of the nuclear export signal (NES).	Belongs to the DNA repair enzymes AP/ExoA family.	Base excision repair;Displacement of DNA glycosylase by APEX1;POLB-Dependent Long Patch Base Excision Repair;Resolution of AP sites via the multiple-nucleotide patch replacement pathway;PCNA-Dependent Long Patch Base Excision Repair;Abasic sugar-phosphate removal via the single-nucleotide replacement pathway;Resolution of Abasic Sites (AP sites)	PE1	14
+NX_P27701	CD82 antigen	267	29626	5.14	4	Cytoplasmic vesicle;Cell membrane	NA	Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.	NA	Belongs to the tetraspanin (TM4SF) family.	p53 signaling pathway	PE1	11
+NX_P27707	Deoxycytidine kinase	260	30519	5.14	0	Nucleoplasm;Nucleus	NA	Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.	Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.	Belongs to the DCK/DGK family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;Pyrimidine salvage;Purine salvage	PE1	4
+NX_P27708	CAD protein	2225	242984	6.02	0	Cytoplasm;Nucleoplasm;Nucleus	Epileptic encephalopathy, early infantile, 50	This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).	Activated by MAP kinase (Erk1/2) phosphorylation just prior to the S phase of the cell cycle, when the demand for pyrimidine nucleotides is greatest, and down-regulated as the cells emerge from S phase by protein kinase A (PKA) phosphorylation. Phosphorylation at Ser-1859 by RPS6KB1 downstream of MTOR promotes oligomerization and stimulates dihydroorotase activity. Phosphorylation at Ser-1406 reduces sensitivity to feedback inhibition by UTP.	In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.;Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.;Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.;Pyrimidine metabolism;Alanine, aspartate and glutamate metabolism;Metabolic pathways;Pyrimidine biosynthesis	PE1	2
+NX_P27797	Calreticulin	417	48142	4.29	0	Extracellular matrix;Cell surface;Endoplasmic reticulum;Cytosol;Endoplasmic reticulum lumen;Sarcoplasmic reticulum lumen	NA	Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).	NA	Belongs to the calreticulin family.	Protein processing in endoplasmic reticulum;Phagosome;Antigen processing and presentation;Chagas disease (American trypanosomiasis);HTLV-I infection;ER-Phagosome pathway;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Scavenging by Class A Receptors;Scavenging by Class F Receptors;ATF6 (ATF6-alpha) activates chaperone genes;Calnexin/calreticulin cycle;Assembly of Viral Components at the Budding Site	PE1	19
+NX_P27815	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	886	98143	5.09	0	Cytoplasm;Cell membrane;Membrane;Ruffle membrane;Perinuclear region	NA	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.	Are activated by phosphorylation at Ser-119 and Ser-123 respectively by PKA.;Proteolytically cleaved by caspase-3.;Phosphorylation by MAPKAPK2 its activation through PKA phosphorylation (By similarity). Phosphorylated at Ser-686 and Ser-688 when expressed in S.frugiperda cells.	Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.;Purine metabolism;G alpha (s) signalling events;DARPP-32 events	PE1	19
+NX_P27816	Microtubule-associated protein 4	1152	121005	5.32	0	Cytosol;Cytoskeleton;Cell membrane	NA	Non-neuronal microtubule-associated protein. Promotes microtubule assembly.	Is phosphorylated on Ser-337 and Ser-338.;Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly.	NA	NA	PE1	3
+NX_P27824	Calnexin	592	67568	4.47	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Melanosome	NA	Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.	Phosphorylated at Ser-564 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).;Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.;Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.	Belongs to the calreticulin family.	Protein processing in endoplasmic reticulum;Phagosome;Antigen processing and presentation;HTLV-I infection;MHC class II antigen presentation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Calnexin/calreticulin cycle;Assembly of Viral Components at the Budding Site;Interleukin-35 Signalling;Interleukin-27 signaling	PE1	5
+NX_P27918	Properdin	469	51276	8.32	0	Secreted	Properdin deficiency	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.	NA	NA	Herpes simplex infection;O-glycosylation of TSR domain-containing proteins;Regulation of Complement cascade;Activation of C3 and C5;Alternative complement activation;Defective B3GALTL causes Peters-plus syndrome (PpS);Neutrophil degranulation	PE1	X
+NX_P27930	Interleukin-1 receptor type 2	398	45421	8.03	1	Secreted;Cell membrane	NA	Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.	A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.	Belongs to the interleukin-1 receptor family.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Hematopoietic cell lineage;Amoebiasis;HTLV-I infection;Interleukin-10 signaling;Interleukin-1 signaling	PE1	2
+NX_P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha	724	83598	5.84	0	Cytosol	Agammaglobulinemia 7, autosomal recessive;SHORT syndrome;Immunodeficiency 36	Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).	Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.;Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear (By similarity). Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR.;PIK3R1 is phosphorylated by KIT;PIK3R1 is phosphorylated by NTRK1;PIK3R1 is phosphorylated by MST1R (Phosphotyrosine:PTM-0255)	Belongs to the PI3K p85 subunit family.	ErbB signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;mTOR signaling pathway;Apoptosis;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Cholinergic synapse;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Carbohydrate digestion and absorption;Bacterial invasion of epithelial cells;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;G alpha (q) signalling events;Synthesis of PIPs at the plasma membrane;Downstream TCR signaling;PI3K Cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;Role of LAT2/NTAL/LAB on calcium mobilization;GPVI-mediated activation cascade;Interleukin-7 signaling;Interleukin receptor SHC signaling;DAP12 signaling;VEGFA-VEGFR2 Pathway;CD28 dependent PI3K/Akt signaling;PI3K events in ERBB4 signaling;PI3K events in ERBB2 signaling;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Interleukin-3, Interleukin-5 and GM-CSF signaling;Nephrin family interactions;Regulation of signaling by CBL;Tie2 Signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Costimulation by the CD28 family;GP1b-IX-V activation signalling;PI3K/AKT activation;Downstream signal transduction;GAB1 signalosome;Constitutive Signaling by EGFRvIII;Signaling by FGFR4 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR3 fusions in cancer;RET signaling;MET activates PI3K/AKT signaling;Interleukin-4 and Interleukin-13 signaling;IRS-mediated signalling;Activated NTRK3 signals through PI3K;Activated NTRK2 signals through PI3K;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Extra-nuclear estrogen signaling;FLT3 Signaling	PE1	5
+NX_P27987	Inositol-trisphosphate 3-kinase B	946	102376	8.7	0	Nucleoplasm	NA	NA	NA	Belongs to the inositol phosphokinase (IPK) family.	Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Phosphatidylinositol signaling system;Synthesis of IP3 and IP4 in the cytosol	PE1	1
+NX_P28039	Acyloxyacyl hydrolase	575	65105	8.45	0	Cytoplasm;Secreted;Lysosome;Cytoplasmic vesicle;Nucleus	NA	Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145, PubMed:29343645). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity).	The small subunit is N-glycosylated.;Cleaved into a large and a small subunit.	NA	NA	PE1	7
+NX_P28062	Proteasome subunit beta type-8	276	30354	7.04	0	Cytoplasmic vesicle;Cytoplasm;Nucleus;Cytoskeleton	Proteasome-associated autoinflammatory syndrome 1	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119). Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.	Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.	Belongs to the peptidase T1B family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Interferon alpha/beta signaling;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	6
+NX_P28065	Proteasome subunit beta type-9	219	23264	4.93	0	Cytoplasm;Cytosol;Nucleus	Proteasome-associated autoinflammatory syndrome 3	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.	Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.	Belongs to the peptidase T1B family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	6
+NX_P28066	Proteasome subunit alpha type-5	241	26411	4.74	0	Cytoplasm;Cytosol;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).	NA	Belongs to the peptidase T1A family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	1
+NX_P28067	HLA class II histocompatibility antigen, DM alpha chain	261	29194	4.51	1	Cytoplasmic vesicle;Lysosome membrane;Late endosome membrane	NA	Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.	NA	Belongs to the MHC class II family.	MHC class II antigen presentation	PE1	6
+NX_P28068	HLA class II histocompatibility antigen, DM beta chain	263	28943	7.09	1	Cytoplasmic vesicle;Lysosome membrane;Late endosome membrane	NA	Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.	NA	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation	PE1	6
+NX_P28069	Pituitary-specific positive transcription factor 1	291	32912	8.36	0	Nucleus	Pituitary hormone deficiency, combined, 1	Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202).	NA	Belongs to the POU transcription factor family. Class-1 subfamily.	NA	PE1	3
+NX_P28070	Proteasome subunit beta type-4	264	29204	5.72	0	Cytoplasm;Nucleus	Proteasome-associated autoinflammatory syndrome 3	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.	NA	Belongs to the peptidase T1B family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	1
+NX_P28072	Proteasome subunit beta type-6	239	25358	4.8	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues.	NA	Belongs to the peptidase T1B family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	17
+NX_P28074	Proteasome subunit beta type-5	263	28480	6.44	0	Nucleoplasm;Cytoplasm;Centrosome;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.	NA	Belongs to the peptidase T1B family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	14
+NX_P28161	Glutathione S-transferase Mu 2	218	25745	5.99	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.	NA	Belongs to the GST superfamily. Mu family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation	PE1	1
+NX_P28221	5-hydroxytryptamine receptor 1D	377	41907	9.03	7	Cell membrane	NA	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Serotonin receptors	PE1	1
+NX_P28222	5-hydroxytryptamine receptor 1B	390	43568	8.96	7	Cell membrane	NA	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.	Palmitoylated.;Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Serotonin receptors	PE1	6
+NX_P28223	5-hydroxytryptamine receptor 2A	471	52603	7.83	7	Cell membrane;Presynapse;Caveola;Cytoplasmic vesicle;Axon;Dendrite	NA	(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.;G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Gap junction;G alpha (q) signalling events;Serotonin receptors	PE1	13
+NX_P28288	ATP-binding cassette sub-family D member 3	659	75476	9.41	4	Peroxisome membrane;Peroxisome	Congenital bile acid synthesis defect 5	Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382). The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (PubMed:11248239).	NA	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.	ABC transporters;Peroxisome;ABC transporters in lipid homeostasis;Class I peroxisomal membrane protein import	PE1	1
+NX_P28289	Tropomodulin-1	359	40569	5.03	0	Cytoskeleton	NA	Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.	NA	Belongs to the tropomodulin family.	Striated Muscle Contraction	PE1	9
+NX_P28290	Protein ITPRID2	1259	138386	5.11	0	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	NA	NA	A 33 kDa peptide corresponding to the C-terminus of this protein is found in the testis and seems to be cleaved into 2 peptides of 14 kDa and 18 kDa found on the surface of mature sperm cells. This sperm surface antigen may be involved in some step of early cleavage of the fertilized oocyte.	NA	NA	PE1	2
+NX_P28300	Protein-lysine 6-oxidase	417	46944	8.36	0	Endoplasmic reticulum;Secreted;Extracellular space	Aortic aneurysm, familial thoracic 10	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).	Sulfated at Tyr-187 and also at either Tyr-183 or Tyr-184 which enhances binding to collagen.;The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.;Proteolytically cleaved by BMP1 which removes the propeptide (PubMed:31152061). Also proteolytically cleaved by ADAMTS2 and ADAMTS14, but not by ADAMTS3, at an additional cleavage site downstream of the BMP1 cleavage site (PubMed:31152061). The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via interaction with tropoelastin (By similarity). Cleavage by BMP1 to remove the propeptide does not increase enzymatic activity but increases binding to collagen (PubMed:31152061). Cleavage by ADAMTS2 produces a form with reduced collagen-binding activity (PubMed:31152061).	Belongs to the lysyl oxidase family.	Elastic fibre formation;Crosslinking of collagen fibrils	PE1	5
+NX_P28324	ETS domain-containing protein Elk-4	431	46900	7.68	0	Nucleoplasm;Nucleus	NA	Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.	ELK4 is phosphorylated by MAPK11 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);ELK4 is phosphorylated by MAPK8;ELK4 is phosphorylated by MAPK7 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the ETS family.	MAPK signaling pathway;HTLV-I infection	PE1	1
+NX_P28325	Cystatin-D	142	16080	6.71	0	Secreted	NA	Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	NA	Belongs to the cystatin family.	Salivary secretion	PE1	20
+NX_P28328	Peroxisome biogenesis factor 2	305	34843	8.98	2	Peroxisome membrane;Cytoplasmic vesicle	Peroxisome biogenesis disorder complementation group 5;Peroxisome biogenesis disorder 5A;Peroxisome biogenesis disorder 5B	Somewhat implicated in the biogenesis of peroxisomes.	NA	Belongs to the pex2/pex10/pex12 family.	Peroxisome;E3 ubiquitin ligases ubiquitinate target proteins;Peroxisomal protein import;Class I peroxisomal membrane protein import	PE1	8
+NX_P28329	Choline O-acetyltransferase	748	82536	8.9	0	NA	Myasthenic syndrome, congenital, 6, presynaptic	Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.	CHAT is phosphorylated by CAMK2A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the carnitine/choline acetyltransferase family.	Glycerophospholipid metabolism;Cholinergic synapse;Synthesis of PC;Acetylcholine Neurotransmitter Release Cycle	PE1	10
+NX_P28330	Long-chain specific acyl-CoA dehydrogenase, mitochondrial	430	47656	7.68	0	Mitochondrion matrix	NA	Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:8823175, PubMed:21237683).	Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3.	Belongs to the acyl-CoA dehydrogenase family.	Lipid metabolism; mitochondrial fatty acid beta-oxidation.;Fatty acid metabolism;Metabolic pathways;PPAR signaling pathway;mitochondrial fatty acid beta-oxidation of unsaturated fatty acids;Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA;Beta oxidation of myristoyl-CoA to lauroyl-CoA	PE1	2
+NX_P28331	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	727	79468	5.89	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 5	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.	NA	Belongs to the complex I 75 kDa subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	2
+NX_P28332	Alcohol dehydrogenase 6	368	39073	8.07	0	Cytoplasm	NA	NA	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily.	Glycolysis / Gluconeogenesis;Fatty acid metabolism;Tyrosine metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Ethanol oxidation	PE1	4
+NX_P28335	5-hydroxytryptamine receptor 2C	458	51821	9.13	7	Cell membrane	NA	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.	N-glycosylated.	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Gap junction;G alpha (q) signalling events;Serotonin receptors	PE1	X
+NX_P28336	Neuromedin-B receptor	390	43435	8.93	7	Cytosol;Cell membrane	NA	Receptor for neuromedin-B.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	6
+NX_P28340	DNA polymerase delta catalytic subunit	1107	123631	6.64	0	Nucleoplasm;Nucleus	Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome;Colorectal cancer 10	As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200, PubMed:24022480). Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196).	NA	Belongs to the DNA polymerase type-B family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination;HTLV-I infection;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Cytosolic iron-sulfur cluster assembly;Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Termination of translesion DNA synthesis;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Polymerase switching on the C-strand of the telomere;Processive synthesis on the C-strand of the telomere;Telomere C-strand (Lagging Strand) Synthesis;Removal of the Flap Intermediate from the C-strand;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER	PE1	19
+NX_P28347	Transcriptional enhancer factor TEF-1	426	47946	8.33	0	Nucleoplasm;Nucleus	Sveinsson chorioretinal atrophy	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.	NA	NA	YAP1- and WWTR1 (TAZ)-stimulated gene expression;RUNX3 regulates YAP1-mediated transcription	PE1	11
+NX_P28356	Homeobox protein Hox-D9	352	36495	9.36	0	Nucleoplasm;Nucleolus;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	2
+NX_P28358	Homeobox protein Hox-D10	340	38411	8.62	0	Nucleoplasm;Cytosol;Nucleus	Vertical talus, congenital	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	2
+NX_P28360	Homeobox protein MSX-1	303	31496	9.89	0	Nucleoplasm;Nucleus	Ectodermal dysplasia 3, Witkop type;Tooth agenesis, selective, 1;Non-syndromic orofacial cleft 5	Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.	Sumoylated by PIAS1, desumoylated by SENP1.	Belongs to the Msh homeobox family.	HTLV-I infection	PE1	4
+NX_P28370	Probable global transcription activator SNF2L1	1054	122605	8.27	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Energy-transducing component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells.	NA	Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.	NA	PE1	X
+NX_P28472	Gamma-aminobutyric acid receptor subunit beta-3	473	54116	9.21	4	Cytoplasmic vesicle membrane;Cell membrane;Postsynaptic cell membrane	Epileptic encephalopathy, early infantile, 43;Epilepsy, childhood absence 5	Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Plays an important role in somatosensation and in the production of antinociception (By similarity).	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;Signaling by ERBB4;GABA receptor activation	PE1	15
+NX_P28476	Gamma-aminobutyric acid receptor subunit rho-2	465	54151	9.27	4	Cell membrane;Postsynaptic cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;GABA receptor activation	PE2	6
+NX_P28482	Mitogen-activated protein kinase 1	360	41390	6.5	0	Cytoplasm;Centrosome;Caveola;Spindle;Nucleus	NA	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).;Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.	ISGylated.;Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Undergoes regulatory phosphorylation on additional residues such as Ser-246 and Ser-248 in the kinase insert domain (KID) These phosphorylations, which are probably mediated by more than one kinase, are important for binding of MAPK1/ERK2 to importin-7 (IPO7) and its nuclear translocation. In addition, autophosphorylation of Thr-190 was shown to affect the subcellular localization of MAPK1/ERK2 as well. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-187. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. DUSP3 and DUSP6 dephosphorylate specifically MAPK1/ERK2 and MAPK3/ERK1 whereas DUSP9 dephosphorylates a broader range of MAPKs. Dephosphorylated by DUSP1 at Thr-185 and Tyr-187.;MAPK1 is phosphorylated by MAP2K7;MAPK1 is phosphorylated by RIPK2	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Oocyte meiosis;mTOR signaling pathway;Vascular smooth muscle contraction;Dorso-ventral axis formation;TGF-beta signaling pathway;Axon guidance;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Adherens junction;Gap junction;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Long-term potentiation;Neurotrophin signaling pathway;Glutamatergic synapse;Cholinergic synapse;Long-term depression;Regulation of actin cytoskeleton;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Alzheimer's disease;Prion diseases;Shigellosis;Salmonella infection;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Hepatitis C;Influenza A;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Thyroid cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;Regulation of HSF1-mediated heat shock response;RAF/MAP kinase cascade;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;Signal transduction by L1;Advanced glycosylation endproduct receptor signaling;Senescence-Associated Secretory Phenotype (SASP);RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway;Recycling pathway of L1;MAP2K and MAPK activation;Growth hormone receptor signaling;Thrombin signalling through proteinase activated receptors (PARs);Oncogene Induced Senescence;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK;NCAM signaling for neurite out-growth;Golgi Cisternae Pericentriolar Stack Reorganization;Signal attenuation;Spry regulation of FGF signaling;RHO GTPases Activate NADPH Oxidases;ERK/MAPK targets;Activation of the AP-1 family of transcription factors;ERKs are inactivated;Frs2-mediated activation;Negative feedback regulation of MAPK pathway;MAPK1 (ERK2) activation;phospho-PLA2 pathway;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Neutrophil degranulation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Regulation of PTEN gene transcription;RUNX2 regulates osteoblast differentiation;ESR-mediated signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling;Regulation of the apoptosome activity;Estrogen-stimulated signaling through PRKCZ	PE1	22
+NX_P28562	Dual specificity protein phosphatase 1	367	39298	6.78	0	Nucleolus;Cytosol;Nucleus	NA	Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.	Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway;RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway	PE1	5
+NX_P28566	5-hydroxytryptamine receptor 1E	365	41682	9.09	7	Cell membrane	NA	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Serotonin receptors	PE1	6
+NX_P28676	Grancalcin	217	24010	5.02	0	Cytoplasm;Cytosol;Cytoplasmic granule membrane;Cell membrane	NA	Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.	NA	NA	Neutrophil degranulation	PE1	2
+NX_P28698	Myeloid zinc finger 1	734	82055	8.59	0	Nucleoplasm;Nucleus	NA	Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P28702	Retinoic acid receptor RXR-beta	533	56922	8.52	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).	NA	Belongs to the nuclear hormone receptor family. NR2 subfamily.	PPAR signaling pathway;Adipocytokine signaling pathway;Pathways in cancer;Thyroid cancer;Small cell lung cancer;Non-small cell lung cancer;PPARA activates gene expression;Nuclear Receptor transcription pathway;Signaling by Retinoic Acid	PE1	6
+NX_P28715	DNA repair protein complementing XP-G cells	1186	133108	5.13	0	Nucleus	Cerebro-oculo-facio-skeletal syndrome 3;Xeroderma pigmentosum complementation group G	Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.	NA	Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.	Dual incision in TC-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER	PE1	13
+NX_P28749	Retinoblastoma-like protein 1	1068	120847	7.32	0	Nucleoplasm;Nucleus	NA	Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904).	Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 and Ser-975 by CDK4.	Belongs to the retinoblastoma protein (RB) family.	Cell cycle;TGF-beta signaling pathway;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;G0 and Early G1;G1/S-Specific Transcription;Cyclin D associated events in G1;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	PE1	20
+NX_P28799	Progranulin	593	63544	6.43	0	Endoplasmic reticulum;Endosome;Secreted;Lysosome	Ceroid lipofuscinosis, neuronal, 11;Ubiquitin-positive frontotemporal dementia	Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28541286, PubMed:28073925, PubMed:18378771, PubMed:28453791, PubMed:12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771).;Granulin-7: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.;Granulin-4: Promotes proliferation of the epithelial cell line A431 in culture.;Granulin-3: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8.	Cleaved by ELANE; proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production; granulin-3 and granulin-4 are resistant to ELANE (PubMed:12526812, PubMed:28743268). Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome (PubMed:28743268).	Belongs to the granulin family.	Neutrophil degranulation	PE1	17
+NX_P28827	Receptor-type tyrosine-protein phosphatase mu	1452	163682	6.21	1	Membrane;Cell membrane	NA	Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.	NA	Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.	Cell adhesion molecules (CAMs);Adherens junction	PE1	18
+NX_P28838	Cytosol aminopeptidase	519	56166	8.03	0	Nucleoplasm;Cytoplasm;Cytosol;Midbody	NA	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.	NA	Belongs to the peptidase M17 family.	Arginine and proline metabolism;Glutathione metabolism;Metabolic pathways	PE1	4
+NX_P28845	Corticosteroid 11-beta-dehydrogenase isozyme 1	292	32401	8.71	1	Endoplasmic reticulum membrane	Cortisone reductase deficiency 2	Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).	Glycosylated.	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Steroid hormone biosynthesis;Metabolism of xenobiotics by cytochrome P450;Metabolic pathways;Aldosterone-regulated sodium reabsorption;Glucocorticoid biosynthesis	PE1	1
+NX_P28906	Hematopoietic progenitor cell antigen CD34	385	40716	7	1	Membrane;Nucleoplasm;Cell junction;Cell membrane	NA	Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.	Highly glycosylated.;Phosphorylated on serine residues by PKC.	Belongs to the CD34 family.	Cell adhesion molecules (CAMs);Hematopoietic cell lineage;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	1
+NX_P28907	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	300	34328	7.85	1	Membrane;Cell membrane	NA	Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.	NA	Belongs to the ADP-ribosyl cyclase family.	Nicotinate and nicotinamide metabolism;Metabolic pathways;Calcium signaling pathway;Hematopoietic cell lineage;Salivary secretion;Pancreatic secretion;Nicotinate metabolism	PE1	4
+NX_P28908	Tumor necrosis factor receptor superfamily member 8	595	63747	5.44	1	Cytoplasm;Cell membrane	NA	Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898).	Phosphorylated on serine and tyrosine residues (Probable).;Is constitutively phosphorylated (PubMed:8839832).	Belongs to the TNFR8 family.	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	1
+NX_P29016	T-cell surface glycoprotein CD1b	333	36939	5.89	1	Endosome membrane;Lysosome membrane;Cell membrane	NA	Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.	NA	NA	Hematopoietic cell lineage;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	1
+NX_P29017	T-cell surface glycoprotein CD1c	333	37654	5.7	1	Endosome membrane;Lysosome;Cell membrane	NA	Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.	NA	NA	Hematopoietic cell lineage;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	1
+NX_P29033	Gap junction beta-2 protein	226	26215	9.11	4	Gap junction;Cell membrane;Mitochondrion	Keratitis-ichthyosis-deafness syndrome;Ichthyosis hystrix-like with deafness syndrome;Deafness, autosomal recessive, 1A;Keratoderma, palmoplantar, with deafness;Knuckle pads, leukonychia, and sensorineural deafness;Deafness, autosomal dominant, 3A;Vohwinkel syndrome	Structural component of gap junctions (PubMed:17551008, PubMed:19340074, PubMed:21094651, PubMed:26753910, PubMed:16849369, PubMed:19384972). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (PubMed:17551008, PubMed:19340074, PubMed:21094651, PubMed:26753910). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:21094651, PubMed:16849369, PubMed:19384972).	NA	Belongs to the connexin family. Beta-type (group I) subfamily.	Gap junction assembly;Oligomerization of connexins into connexons;Transport of connexins along the secretory pathway;Transport of connexons to the plasma membrane	PE1	13
+NX_P29034	Protein S100-A2	98	11117	4.68	0	Cytoplasm;Cell membrane;Nucleolus;Nucleoplasm;Cytosol	NA	May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.	NA	Belongs to the S-100 family.	NA	PE1	1
+NX_P29074	Tyrosine-protein phosphatase non-receptor type 4	926	105911	7.15	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Cytoskeleton	NA	Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton.	Cleaved and activated by calpain I/CAPN1.;Highly phosphorylated on serine and threonine residues but not on tyrosines.	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.	Toll Like Receptor 4 (TLR4) Cascade;Interleukin-37 signaling;MECP2 regulates neuronal receptors and channels	PE1	2
+NX_P29083	General transcription factor IIE subunit 1	439	49452	4.74	0	Nucleoplasm;Nucleus	NA	Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	NA	Belongs to the TFIIE alpha subunit family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA polymerase II transcribes snRNA genes	PE1	3
+NX_P29084	Transcription initiation factor IIE subunit beta	291	33044	9.66	0	Nucleoplasm;Cytosol;Nucleus	Trichothiodystrophy 6, non-photosensitive	Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	NA	Belongs to the TFIIE beta subunit family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA polymerase II transcribes snRNA genes	PE1	8
+NX_P29120	Neuroendocrine convertase 1	753	84152	5.66	0	Secretory vesicle	Proprotein convertase 1 deficiency	Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.	O-glycosylated.	Belongs to the peptidase S8 family. Furin subfamily.	Insulin processing;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);Synthesis, secretion, and deacylation of Ghrelin;Peptide hormone biosynthesis	PE1	5
+NX_P29122	Proprotein convertase subtilisin/kexin type 6	969	106420	7.96	0	Endoplasmic reticulum;Endomembrane system;Secreted	NA	Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.	NA	Belongs to the peptidase S8 family.	Signaling by NODAL;NGF processing;Formation of the cornified envelope;Assembly of active LPL and LIPC lipase complexes	PE1	15
+NX_P29144	Tripeptidyl-peptidase 2	1249	138350	5.9	0	Cytoplasm;Cytosol;Nucleus	NA	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity).	NA	Belongs to the peptidase S8 family.	Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	13
+NX_P29218	Inositol monophosphatase 1	277	30189	5.16	0	Cytoplasm;Nucleoplasm;Mitochondrion	Mental retardation, autosomal recessive 59	Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.	NA	Belongs to the inositol monophosphatase superfamily.	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.;Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of IP2, IP, and Ins in the cytosol	PE1	8
+NX_P29274	Adenosine receptor A2a	412	44707	8.34	7	Cell membrane	NA	Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).	Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface.	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;G alpha (s) signalling events;Adenosine P1 receptors;NGF-independant TRKA activation;Surfactant metabolism	PE1	22
+NX_P29275	Adenosine receptor A2b	332	36333	8.62	7	Cytosol;Cell membrane	NA	Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;G alpha (s) signalling events;Adenosine P1 receptors;Surfactant metabolism	PE1	17
+NX_P29279	CCN family member 2	349	38091	8.43	0	Golgi apparatus;Extracellular matrix;Secreted;Cytoplasmic vesicle	NA	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.	NA	Belongs to the CCN family.	YAP1- and WWTR1 (TAZ)-stimulated gene expression;RUNX3 regulates YAP1-mediated transcription	PE1	6
+NX_P29317	Ephrin type-A receptor 2	976	108266	5.86	1	Golgi apparatus;Nucleus speckle;Cell membrane;Cell junction;Focal adhesion;Lamellipodium membrane;Ruffle membrane	Cataract 6, multiple types	(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.;Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.	Ubiquitinated by CHIP/STUB1. Ubiquitination is regulated by the HSP90 chaperone and regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By similarity).;Autophosphorylates. Phosphorylated on tyrosine upon binding and activation by EFNA1. Phosphorylated residues Tyr-588 and Tyr-594 are required for binding VAV2 and VAV3 while phosphorylated residues Tyr-735 and Tyr-930 are required for binding PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3). These phosphorylated residues are critical for recruitment of VAV2 and VAV3 and PI3-kinase p85 subunit which transduce downstream signaling to activate RAC1 GTPase and cell migration. Dephosphorylation of Tyr-930 by PTPRF prevents the interaction of EPHA2 with NCK1. Phosphorylated at Ser-897 by PKB; serum-induced phosphorylation which targets EPHA2 to the cell leading edge and stimulates cell migration. Phosphorylation by PKB is inhibited by EFNA1-activated EPHA2 which regulates PKB activity via a reciprocal regulatory loop. Phosphorylated at Ser-897 in response to TNF by RPS6KA1 and RPS6KA3; RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Phosphorylated at Ser-897 by PKA; blocks cell retraction induced by EPHA2 kinase activity (PubMed:27385333). Dephosphorylated by ACP1.;EPHA2 is phosphorylated by ERBB2	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	1
+NX_P29320	Ephrin type-A receptor 3	983	110131	6.33	1	Cell membrane;Secreted;Nucleus membrane;Nucleoplasm;Cytosol;Cytoskeleton	Colorectal cancer	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.	Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	3
+NX_P29322	Ephrin type-A receptor 8	1005	111003	8.42	1	Early endosome membrane;Cell projection;Cell membrane	NA	Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).	Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By similarity).;Phosphorylated. Phosphorylation is stimulated upon binding of its ligands including EFNA2, EFNA3 and EFNA5. Autophosphorylation on Tyr-616 is critical for association with FYN. Autophosphorylation on Tyr-839 modulates tyrosine kinase activity (By similarity).	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	1
+NX_P29323	Ephrin type-B receptor 2	1055	117493	6.14	1	Nucleoplasm;Axon;Dendrite;Cell membrane	Prostate cancer	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.	Ligand binding induces cleavage by matrix metalloproteinases (MMPs) such as MMP7/MMP9, producing an EphB2/N-terminal fragment (NTF) and a C-terminal long fragment (EphB2-LF). EphB2-LF is further cleaved by MMPs, producing EphB2/CTF1 which is further cleaved by the PS1/gamma-secretase producing EphB2/CTF2.;Polyubiquitinated; ligand binding stimulates ubiquitination.;Autophosphorylated; ligand binding stimulates autophosphorylation on tyrosine residues.;EPHB2 is phosphorylated by ABL2 (Phosphotyrosine:PTM-0255);EPHB2 is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;L1CAM interactions	PE1	1
+NX_P29350	Tyrosine-protein phosphatase non-receptor type 6	595	67561	7.65	0	Nucleoplasm;Cytoplasm;Nucleolus;Nucleus	NA	Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.	Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.;PTPN6 is phosphorylated by LYN (Phosphotyrosine:PTM-0255);PTPN6 is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PTPN6 is phosphorylated by PRKG2 (Phosphoserine:PTM-0253)	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.	Adherens junction;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Leishmaniasis;Interferon gamma signaling;Interferon alpha/beta signaling;PD-1 signaling;GPVI-mediated activation cascade;Interleukin receptor SHC signaling;Regulation of IFNA signaling;Growth hormone receptor signaling;Regulation of KIT signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Interleukin-3, Interleukin-5 and GM-CSF signaling;Signal regulatory protein family interactions;PECAM1 interactions;Regulation of IFNG signaling;Platelet sensitization by LDL;Costimulation by the CD28 family;CD22 mediated BCR regulation;Neutrophil degranulation;Interleukin-37 signaling	PE1	12
+NX_P29353	SHC-transforming protein 1	583	62822	6.01	0	Cytoplasm;Mitochondrion matrix;Mitochondrion;Cytosol	NA	Does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span.;Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF.;May thus function as initiators of the Ras signaling cascade in various non-neuronal systems.;Acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.;Once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.	Is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light (By similarity). Tyrosine phosphorylated in response to FLT3 signaling (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1; tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normal brain tissue.;Dephosphorylation by PTPN2 may regulate interaction with GRB2.;Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling.;Are phosphorylated on tyrosine residues of the Pro-rich domain.;SHC1 is phosphorylated by FGFR3;SHC1 is phosphorylated by NTRK1;SHC1 is phosphorylated by PDGFRB (Phosphotyrosine:PTM-0255);SHC1 is phosphorylated by ALK (Phosphotyrosine:PTM-0255);SHC1 is phosphorylated by RET (Phosphotyrosine:PTM-0255);SHC1 is phosphorylated by LCK (Phosphotyrosine:PTM-0255);SHC1 is phosphorylated by NTRK2 (Phosphotyrosine:PTM-0255);SHC1 is phosphorylated by IGF1R (Phosphotyrosine:PTM-0255)	NA	ErbB signaling pathway;Chemokine signaling pathway;Focal adhesion;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Insulin signaling pathway;Bacterial invasion of epithelial cells;Glioma;Chronic myeloid leukemia;RAF/MAP kinase cascade;SHC-mediated cascade:FGFR1;SHC-mediated cascade:FGFR2;SHC-mediated cascade:FGFR3;SHC-mediated cascade:FGFR4;Role of LAT2/NTAL/LAB on calcium mobilization;Interleukin receptor SHC signaling;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;XBP1(S) activates chaperone genes;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling;Signal attenuation;Insulin receptor signalling cascade;Integrin alphaIIb beta3 signaling;Tie2 Signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Signalling to RAS;Constitutive Signaling by EGFRvIII;SHC1 events in EGFR signaling;SHC-related events triggered by IGF1R;RET signaling;MET activates RAS signaling;Interleukin-15 signaling;Interleukin-2 signaling;Activated NTRK2 signals through RAS;Activated NTRK3 signals through RAS;Erythropoietin activates RAS;Extra-nuclear estrogen signaling	PE1	1
+NX_P29371	Neuromedin-K receptor	465	52202	9.42	7	Cell membrane	Hypogonadotropic hypogonadism 11 with or without anosmia	This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.	The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Tachykinin receptors bind tachykinins	PE1	4
+NX_P29372	DNA-3-methyladenine glycosylase	298	32869	9.65	0	Cytoplasm;Mitochondrion nucleoid;Nucleoplasm;Cytosol;Nucleus	NA	Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.	NA	Belongs to the DNA glycosylase MPG family.	Base excision repair;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Displacement of DNA glycosylase by APEX1	PE1	16
+NX_P29373	Cellular retinoic acid-binding protein 2	138	15693	5.42	0	Cytoplasm;Endoplasmic reticulum;Nucleoplasm;Cytosol;Nucleus	NA	Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.	Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Signaling by Retinoic Acid	PE1	1
+NX_P29374	AT-rich interactive domain-containing protein 4A	1257	142752	5.02	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).	NA	NA	HDACs deacetylate histones	PE1	14
+NX_P29375	Lysine-specific demethylase 5A	1690	192095	6.12	0	Nucleolus;Nucleus;Cytosol	NA	Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228).	NA	Belongs to the JARID1 histone demethylase family.	HDMs demethylate histones	PE1	12
+NX_P29376	Leukocyte tyrosine kinase receptor	864	91681	6.07	1	Membrane;Cytoplasmic vesicle	NA	Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.	NA	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	NA	PE1	15
+NX_P29377	Protein S100-G	79	9016	4.69	0	NA	NA	NA	NA	Belongs to the S-100 family.	Mineral absorption	PE1	X
+NX_P29400	Collagen alpha-5(IV) chain	1685	161044	7.71	0	Basement membrane	Alport syndrome 1, X-linked	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.;Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.;The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.	Belongs to the type IV collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Pathways in cancer;Small cell lung cancer;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Non-integrin membrane-ECM interactions;Laminin interactions;Crosslinking of collagen fibrils;Anchoring fibril formation;Extracellular matrix organization;Collagen chain trimerization;Regulation of expression of SLITs and ROBOs	PE1	X
+NX_P29401	Transketolase	623	67878	7.58	0	Nucleoplasm	Short stature, developmental delay, and congenital heart defects	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	NA	Belongs to the transketolase family.	Pentose phosphate pathway;Metabolic pathways;Pentose phosphate pathway;Insulin effects increased synthesis of Xylulose-5-Phosphate	PE1	3
+NX_P29459	Interleukin-12 subunit alpha	219	24874	6.21	0	Secreted	NA	Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	NA	Belongs to the IL-6 superfamily.	Cytokine-cytokine receptor interaction;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Jak-STAT signaling pathway;Type I diabetes mellitus;Pertussis;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);African trypanosomiasis;Malaria;Toxoplasmosis;Amoebiasis;Tuberculosis;Measles;Influenza A;Herpes simplex infection;Allograft rejection;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Interleukin-35 Signalling;Interleukin-12 signaling	PE1	3
+NX_P29460	Interleukin-12 subunit beta	328	37169	5.52	0	Secreted	Immunodeficiency 29;Psoriasis 11	Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.;Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.	Belongs to the type I cytokine receptor family. Type 3 subfamily.	Cytokine-cytokine receptor interaction;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Jak-STAT signaling pathway;Type I diabetes mellitus;Pertussis;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);African trypanosomiasis;Toxoplasmosis;Amoebiasis;Tuberculosis;Measles;Influenza A;Herpes simplex infection;Allograft rejection;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Interleukin-12 signaling;Interleukin-23 signaling	PE1	5
+NX_P29466	Caspase-1	404	45159	5.63	0	Cytoplasm;Nucleoplasm;Cytosol;Cell membrane	NA	Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (PubMed:20197547).	The two subunits are derived from the precursor sequence by an autocatalytic mechanism.	Belongs to the peptidase C14A family.	NOD-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Amyotrophic lateral sclerosis (ALS);Salmonella infection;Pertussis;Legionellosis;Influenza A;NOD1/2 Signaling Pathway;The NLRP3 inflammasome;The AIM2 inflammasome;Interleukin-1 processing;The IPAF inflammasome;TP53 Regulates Transcription of Caspase Activators and Caspases;Interleukin-37 signaling	PE1	11
+NX_P29474	Nitric oxide synthase, endothelial	1203	133275	6.94	0	Golgi apparatus;Caveola;Cytoskeleton;Cell membrane	NA	Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.;Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.	Phosphorylation by AMPK at Ser-1177 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity (By similarity). Phosphorylation of Ser-114 by CDK5 reduces activity.	Belongs to the NOS family.	Arginine and proline metabolism;Metabolic pathways;Calcium signaling pathway;VEGF signaling pathway;VEGFR2 mediated vascular permeability;ROS and RNS production in phagocytes;eNOS activation;NOSTRIN mediated eNOS trafficking;Nitric oxide stimulates guanylate cyclase;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;NOSIP mediated eNOS trafficking;Extra-nuclear estrogen signaling	PE1	7
+NX_P29475	Nitric oxide synthase, brain	1434	160970	7.1	0	Nucleoplasm;Dendritic spine;Sarcolemma;Cell membrane	NA	Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.	Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).	Belongs to the NOS family.	Arginine and proline metabolism;Metabolic pathways;Calcium signaling pathway;Phagosome;Long-term depression;Salivary secretion;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);ROS and RNS production in phagocytes;Nitric oxide stimulates guanylate cyclase;Ion homeostasis	PE1	12
+NX_P29508	Serpin B3	390	44565	6.35	0	Cytoplasm;Cytosol;Cell membrane	NA	May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).	NA	Belongs to the serpin family. Ov-serpin subfamily.	Amoebiasis;Neutrophil degranulation	PE1	18
+NX_P29536	Leiomodin-1	600	67030	9.35	0	Cytosol;Cytoskeleton;Sarcomere	NA	Mediates nucleation of actin filaments.	NA	Belongs to the tropomodulin family.	Smooth Muscle Contraction	PE1	1
+NX_P29558	RNA-binding motif, single-stranded-interacting protein 1	406	44505	8.91	0	Cytosol;Nucleus	NA	Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.	NA	NA	NA	PE1	2
+NX_P29590	Protein PML	882	97551	5.88	0	Cytoplasm;Endoplasmic reticulum membrane;Nucleolus;Nucleoplasm;PML body;Early endosome membrane;Nucleus	NA	Exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs.;Represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription.;Also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function.;Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions.;Inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus.;Is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration.;Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures.;Restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm.;Has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation).;Shows restriction activity towards human cytomegalovirus (HCMV) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs.	Acetylation at Lys-487 is essential for its nuclear localization. Deacetylated at Lys-487 by SIRT1 and this deacetylation promotes PML control of PER2 nuclear localization.;Sumoylation regulates PML's: stability in response to extracellular or intracellular stimuli, transcription directly and indirectly, through sequestration of or dissociation of the transcription factors from PML-NBs, ability to regulate apoptosis and its anti-viral activities. It is also essential for: maintaining proper PML nuclear bodies (PML-NBs) structure and normal function, recruitment of components of PML-NBs, the turnover and retention of PML in PML-NBs and the integrity of PML-NBs. Undergoes 'Lys-11'-linked sumoylation. Sumoylation on all three sites (Lys-65, Lys-160 and Lys-490) is required for nuclear body formation. Sumoylation on Lys-160 is a prerequisite for sumoylation on Lys-65. Lys-65 and Lys-160 are sumoylated by PISA1 and PIAS2. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 and phosphorylation at Ser-565 which in turn triggers its ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML-RARA promotes its ubiquitin-mediated degradation. The PML-RARA fusion protein requires the coiled-coil domain for sumoylation. Sumoylation at Lys-490 by RANBP2 is essential for the proper assembly of PML-NBs. SUMO1P1/SUMO5 conjugated PML at Lys-160, Lys-380, Lys-400, Lys-490 and Lys-497, but Lys-380, Lys-400 and Lys-497 are not key acceptor lysines. SUMO1P1/SUMO5 forms polymeric chain on Lys-160 of PML by successive conjugation at 'Lys-18'; facilitating recruitment of PML-NB components, which enlarges PML. SUMO1P1/SUMO5 conjugation of PML increases SUMO2/3 conjugation, which leads to the recruitment of RNF4 and ubiquitin-dependent disintegration of PML-NBs. SUMO1P1/SUMO5 monoconjugated Lys-490 (PubMed:27211601). DNA damage triggers its sumoylation while some but not all viral infections can abolish sumoylation. Desumoylated by SENP1, SENP2, SENP3, SENP5 and SENP6 (PubMed:27211601, PubMed:12419228, PubMed:21148299). Arsenic induces PML and PML-RARA polysumoylation and their subsequent RNF4-dependent ubiquitination and proteasomal degradation, and is used as treatment in acute promyelocytic leukemia (APL). The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6) show an increased sumoylation in response to arsenic trioxide. The cytoplasmic isoform PML-7 is not sumoylated.;Phosphorylation is a major regulatory mechanism that controls PML protein abundance and the number and size of PML nuclear bodies (PML-NBs). Phosphorylated in response to DNA damage, probably by ATR. HIPK2-mediated phosphorylation at Ser-8, Ser-36 and Ser-38 leads to increased accumulation of PML protein and its sumoylation and is required for the maximal pro-apoptotic activity of PML after DNA damage. CHEK2-mediated phosphorylation at Ser-117 is important for PML-mediated apoptosis following DNA damage. MAPK1-mediated phosphorylations at Ser-403, Ser-505, Ser-527 and Ser-530 and CDK1/2-mediated phosphorylation at Ser-518 promote PIN1-dependent PML degradation. CK2-mediated phosphorylation at Ser-565 primes PML ubiquitination via an unidentified ubiquitin ligase.;Ubiquitinated; mediated by RNF4, RNF111, UHRF1, UBE3A/E6AP, BCR(KLHL20) E3 ubiquitin ligase complex E3 ligase complex, SIAH1 or SIAH2 and leading to subsequent proteasomal degradation (PubMed:18408734, PubMed:21840486, PubMed:22033920). Ubiquitination by BCR(KLHL20) E3 ubiquitin ligase complex E3 ligase complex requires CDK1/2-mediated phosphorylation at Ser-518 which in turn is recognized by prolyl-isopeptidase PIN1 and PIN1-catalyzed isomerization further potentiates PML interaction with KLHL20 (PubMed:21840486, PubMed:22033920). 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4 is polysumoylation-dependent (PubMed:18408734). Ubiquitination by RNF111 is polysumoylation-dependent (By similarity).;PML is phosphorylated by CHEK2;PML is phosphorylated by ATR	NA	Ubiquitin mediated proteolysis;Endocytosis;Influenza A;Herpes simplex infection;Pathways in cancer;Acute myeloid leukemia;SUMOylation of DNA damage response and repair proteins;Interferon gamma signaling;Regulation of TP53 Activity through Acetylation;Regulation of PTEN localization;Regulation of RUNX1 Expression and Activity;SUMOylation of ubiquitinylation proteins;Transcriptional regulation of granulopoiesis	PE1	15
+NX_P29597	Non-receptor tyrosine-protein kinase TYK2	1187	133650	6.71	0	Cytosol	Immunodeficiency 35	Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.	NA	Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.	Osteoclast differentiation;Jak-STAT signaling pathway;Toxoplasmosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Interferon alpha/beta signaling;Regulation of IFNA signaling;MAPK3 (ERK1) activation;Interleukin-6 signaling;MAPK1 (ERK2) activation;Interleukin-20 family signaling;IL-6-type cytokine receptor ligand interactions;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Other interleukin signaling;Interleukin-35 Signalling;Interleukin-12 signaling;Interleukin-23 signaling;Interleukin-27 signaling	PE1	19
+NX_P29622	Kallistatin	427	48542	7.34	0	Secreted	NA	Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.	The N-terminus is blocked.	Belongs to the serpin family.	Platelet degranulation	PE1	14
+NX_P29692	Elongation factor 1-delta	281	31122	4.9	0	Nucleoplasm;Nucleolus;Nucleus	NA	Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).;EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.	NA	Belongs to the EF-1-beta/EF-1-delta family.	Herpes simplex infection;Eukaryotic Translation Elongation	PE1	8
+NX_P29728	2'-5'-oligoadenylate synthase 2	719	82431	8.55	0	Cytoplasm;Centrosome;Perinuclear region	NA	Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:9880569, PubMed:11682059). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity).	Glycosylated. Glycosylation is essential for its activity.;Myristoylation is not essential for its activity.	Belongs to the 2-5A synthase family.	Hepatitis C;Measles;Influenza A;Herpes simplex infection;Interferon gamma signaling;Interferon alpha/beta signaling;OAS antiviral response	PE1	12
+NX_P29762	Cellular retinoic acid-binding protein 1	137	15566	5.3	0	Cytoplasm	NA	Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	RA biosynthesis pathway	PE1	15
+NX_P29803	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial	388	42933	8.76	0	Mitochondrion matrix	NA	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.	Phosphorylation at Ser-205, Ser-266 and Ser-273 by PDK family kinases inactivates the enzyme; for this phosphorylation at a single site is sufficient. Phosphorylation at Ser-266 interferes with access to active site, and thereby inactivates the enzyme. Dephosphorylation at all three sites, i.e. At Ser-205, Ser-266 and Ser-273, is required for reactivation.	NA	Glycolysis / Gluconeogenesis;Citrate cycle (TCA cycle);Valine, leucine and isoleucine biosynthesis;Pyruvate metabolism;Butanoate metabolism;Metabolic pathways;Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex;Pyruvate metabolism;Glyoxylate metabolism and glycine degradation	PE1	4
+NX_P29965	CD40 ligand	261	29274	8.53	1	Cell surface;Secreted;Cell membrane	Immunodeficiency with hyper-IgM, type 1	Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).;Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.	The soluble form derives from the membrane form by proteolytic processing.;N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.;Not O-glycosylated.	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;Cell adhesion molecules (CAMs);T cell receptor signaling pathway;Intestinal immune network for IgA production;Malaria;Toxoplasmosis;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Allograft rejection;Primary immunodeficiency;Viral myocarditis;TNFR2 non-canonical NF-kB pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	PE1	X
+NX_P29966	Myristoylated alanine-rich C-kinase substrate	332	31555	4.47	0	Cell membrane;Membrane;Endoplasmic reticulum;Nucleoplasm;Cytosol;Cytoskeleton	NA	MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.	Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.;MARCKS is phosphorylated by PKN1 (Phosphoserine:PTM-0253);MARCKS is phosphorylated by PRKCE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the MARCKS family.	Fc gamma R-mediated phagocytosis;Acetylcholine regulates insulin secretion	PE1	6
+NX_P29972	Aquaporin-1	269	28526	6.95	6	Cell membrane	NA	Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family.	Proximal tubule bicarbonate reclamation;Bile secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins;Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide	PE1	7
+NX_P29973	cGMP-gated cation channel alpha-1	690	79586	7.85	6	Cytoplasmic vesicle;Nucleoplasm;Membrane;Cell membrane	Retinitis pigmentosa 49	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.	NA	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily.	Phototransduction;Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade	PE1	4
+NX_P29992	Guanine nucleotide-binding protein subunit alpha-11	359	42123	5.51	0	Cytoplasm;Cell membrane	Hypocalcemia, autosomal dominant 2;Hypocalciuric hypercalcemia, familial 2	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.	(Microbial infection) Deamidated at Gln-209 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.	Belongs to the G-alpha family. G(q) subfamily.	Calcium signaling pathway;Vascular smooth muscle contraction;Gap junction;Cholinergic synapse;Long-term depression;GnRH signaling pathway;Chagas disease (American trypanosomiasis);Amoebiasis;G alpha (q) signalling events;ADP signalling through P2Y purinoceptor 1;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion;Acetylcholine regulates insulin secretion	PE1	19
+NX_P30038	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	563	61719	8.25	0	Mitochondrion matrix	Hyperprolinemia 2	Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.	NA	Belongs to the aldehyde dehydrogenase family.	Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.;Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;Metabolic pathways;Glyoxylate metabolism and glycine degradation;Proline catabolism	PE1	1
+NX_P30039	Phenazine biosynthesis-like domain-containing protein	288	31785	6.06	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the PhzF family.	NA	PE1	10
+NX_P30040	Endoplasmic reticulum resident protein 29	261	28993	6.77	0	Endoplasmic reticulum;Nucleoplasm;Melanosome;Endoplasmic reticulum lumen;Cytoskeleton	NA	Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.	NA	NA	Protein processing in endoplasmic reticulum	PE1	12
+NX_P30041	Peroxiredoxin-6	224	25035	6	0	Cytoplasm;Cytosol;Lysosome;Cell membrane	NA	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.	Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme.;Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress.	Belongs to the peroxiredoxin family. Prx6 subfamily.	Phenylalanine metabolism;Metabolic pathways;Detoxification of Reactive Oxygen Species;Neutrophil degranulation	PE1	1
+NX_P30043	Flavin reductase (NADPH)	206	22119	7.13	0	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	NA	Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.	NA	NA	Riboflavin metabolism;Porphyrin and chlorophyll metabolism;Heme degradation	PE1	19
+NX_P30044	Peroxiredoxin-5, mitochondrial	214	22086	8.93	0	Cytoplasm;Mitochondrion;Peroxisome matrix	NA	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.	NA	Belongs to the peroxiredoxin family. Prx5 subfamily.	Peroxisome;Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes	PE1	11
+NX_P30046	D-dopachrome decarboxylase	118	12712	6.72	0	Cytoplasm;Mitochondrion	NA	Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).	NA	Belongs to the MIF family.	Dopaminergic synapse	PE1	22
+NX_P30047	GTP cyclohydrolase 1 feedback regulatory protein	84	9698	6.08	0	Cytoplasm;Nucleus membrane;Nucleoplasm;Cytosol;Nucleus	NA	Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.	NA	Belongs to the GFRP family.	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	PE1	15
+NX_P30048	Thioredoxin-dependent peroxide reductase, mitochondrial	256	27693	7.68	0	Cytoplasm;Early endosome;Mitochondrion	NA	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477).	Phosphorylated by LRRK2; phosphorylation reduces perodixase activity.;The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.;PRDX3 is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.	Detoxification of Reactive Oxygen Species	PE1	10
+NX_P30049	ATP synthase subunit delta, mitochondrial	168	17490	5.38	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex V deficiency, nuclear type 5	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:29478781). F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (PubMed:1531933).	NA	Belongs to the ATPase epsilon chain family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	19
+NX_P30050	60S ribosomal protein L12	165	17819	9.48	0	Golgi apparatus	NA	Binds directly to 26S ribosomal RNA.	RPL12 is phosphorylated by MAPK3	Belongs to the universal ribosomal protein uL11 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	9
+NX_P30084	Enoyl-CoA hydratase, mitochondrial	290	31387	8.34	0	Mitochondrion matrix;Mitochondrion	Mitochondrial short-chain enoyl-CoA hydratase 1 deficiency	Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate.	NA	Belongs to the enoyl-CoA hydratase/isomerase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid elongation;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Lysine degradation;Tryptophan metabolism;beta-Alanine metabolism;Propanoate metabolism;Butanoate metabolism;Metabolic pathways;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA;Beta oxidation of hexanoyl-CoA to butanoyl-CoA;Beta oxidation of butanoyl-CoA to acetyl-CoA;Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	PE1	10
+NX_P30085	UMP-CMP kinase	196	22222	5.44	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.	NA	Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Pyrimidine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	1
+NX_P30086	Phosphatidylethanolamine-binding protein 1	187	21057	7.01	0	Cytoplasm;Cell membrane	NA	HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).;Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.	NA	Belongs to the phosphatidylethanolamine-binding protein family.	Negative regulation of MAPK pathway;MAP2K and MAPK activation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	12
+NX_P30101	Protein disulfide-isomerase A3	505	56782	5.98	0	Endoplasmic reticulum;Endoplasmic reticulum lumen;Melanosome	NA	NA	PDIA3 is phosphorylated by MAPK3	Belongs to the protein disulfide isomerase family.	Protein processing in endoplasmic reticulum;Antigen processing and presentation;ER-Phagosome pathway;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Calnexin/calreticulin cycle	PE1	15
+NX_P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	589	65309	5	0	Cytoplasm;Lateral cell membrane;Centromere;Cytosol;Dendrite;Nucleus	Mental retardation, autosomal dominant 36	The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887).	NA	Belongs to the phosphatase 2A regulatory subunit A family.	mRNA surveillance pathway;Oocyte meiosis;Wnt signaling pathway;TGF-beta signaling pathway;Tight junction;Dopaminergic synapse;Long-term depression;Chagas disease (American trypanosomiasis);Hepatitis C;Degradation of beta-catenin by the destruction complex;Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Negative regulation of MAPK pathway;Initiation of Nuclear Envelope Reformation;Cyclin A/B1/B2 associated events during G2/M transition;MASTL Facilitates Mitotic Progression;RAF activation;DARPP-32 events;Recruitment of NuMA to mitotic centrosomes;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Cyclin D associated events in G1;CTLA4 inhibitory signaling;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Spry regulation of FGF signaling;Platelet sensitization by LDL;ERK/MAPK targets;Integration of energy metabolism;PP2A-mediated dephosphorylation of key metabolic factors;ERKs are inactivated;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;AURKA Activation by TPX2;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Regulation of TP53 Degradation;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	19
+NX_P30154	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform	601	66214	4.84	0	Nucleoplasm;Cytosol;Centrosome;Cell membrane	NA	The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.	NA	Belongs to the phosphatase 2A regulatory subunit A family.	mRNA surveillance pathway;Oocyte meiosis;Wnt signaling pathway;TGF-beta signaling pathway;Tight junction;Dopaminergic synapse;Long-term depression;Chagas disease (American trypanosomiasis);Hepatitis C;Degradation of beta-catenin by the destruction complex;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Negative regulation of MAPK pathway;Cyclin A/B1/B2 associated events during G2/M transition;MASTL Facilitates Mitotic Progression;RAF activation;DARPP-32 events;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Cyclin D associated events in G1;CTLA4 inhibitory signaling;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Platelet sensitization by LDL;ERK/MAPK targets;Integration of energy metabolism;PP2A-mediated dephosphorylation of key metabolic factors;ERKs are inactivated;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Regulation of TP53 Degradation;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	11
+NX_P30203	T-cell differentiation antigen CD6	668	71801	4.82	1	Secreted;Cell membrane	NA	Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).	After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.;Glycosylated.	NA	Cell adhesion molecules (CAMs)	PE1	11
+NX_P30260	Cell division cycle protein 27 homolog	824	91867	6.59	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	Phosphorylated. Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis.	Belongs to the APC3/CDC27 family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	17
+NX_P30273	High affinity immunoglobulin epsilon receptor subunit gamma	86	9667	6.54	1	Cell membrane	NA	Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.	NA	Belongs to the CD3Z/FCER1G family.	Natural killer cell mediated cytotoxicity;Fc epsilon RI signaling pathway;Tuberculosis;Asthma;FCERI mediated NF-kB activation;Role of LAT2/NTAL/LAB on calcium mobilization;GPVI-mediated activation cascade;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Dectin-2 family;Fc epsilon receptor (FCERI) signaling;Platelet Adhesion to exposed collagen;Neutrophil degranulation	PE1	1
+NX_P30279	G1/S-specific cyclin-D2	289	33067	5.06	0	Membrane;Cytoplasm;Nucleoplasm;Nucleus	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).	Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.	Belongs to the cyclin family. Cyclin D subfamily.	Cell cycle;p53 signaling pathway;Wnt signaling pathway;Focal adhesion;Jak-STAT signaling pathway;Measles;HTLV-I infection;Cyclin D associated events in G1;Regulation of RUNX1 Expression and Activity	PE1	12
+NX_P30281	G1/S-specific cyclin-D3	292	32520	6.66	0	Cytoplasm;Membrane;Nucleoplasm;Cytosol;Nucleus	NA	Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.	Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.	Belongs to the cyclin family. Cyclin D subfamily.	Cell cycle;p53 signaling pathway;Wnt signaling pathway;Focal adhesion;Jak-STAT signaling pathway;Measles;HTLV-I infection;MAPK6/MAPK4 signaling;Transcriptional regulation of white adipocyte differentiation;Cyclin D associated events in G1;Regulation of RUNX1 Expression and Activity	PE1	6
+NX_P30291	Wee1-like protein kinase	646	71597	6.33	0	Nucleolus;Nucleus	NA	Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.	Ubiquitinated and degraded at the onset of G2/M phase.;Dephosphorylated at Thr-239 by CTDP1.;Phosphorylated during M and G1 phases. Also autophosphorylated. Phosphorylation at Ser-642 by BRSK1 and BRSK2 in post-mitotic neurons, leads to down-regulate WEE1 activity in polarized neurons. Phosphorylated at Ser-53 and Ser-123 by PLK1 and CDK1, respectively, generating an signal for degradation that can be recognized by the SCF(BTRC) complex, leading to its ubiquitination and degradation at the onset of G2/M phase.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.	Cell cycle;Factors involved in megakaryocyte development and platelet production;Polo-like kinase mediated events;Cyclin E associated events during G1/S transition;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;Cyclin A:Cdk2-associated events at S phase entry;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	PE1	11
+NX_P30301	Lens fiber major intrinsic protein	263	28122	8.62	6	Gap junction;Cell membrane	Cataract 15, multiple types	Water channel (PubMed:24120416). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (PubMed:24120416).	Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes (By similarity).;Fatty acylated at Met-1 and Lys-238. The acyl modifications, in decreasing order of ion abundance, are: oleoyl (C18:1) > palmitoyl (C16:0) > stearoyl (C18:0) > eicosenoyl (C20:1) > dihomo-gamma-linolenoyl (C20:3) > palmitoleoyl (C16:1) > eicosadienoyl (C20:2).	Belongs to the MIP/aquaporin (TC 1.A.8) family.	Passive transport by Aquaporins	PE1	12
+NX_P30304	M-phase inducer phosphatase 1	524	59087	6.49	0	Golgi apparatus;Cytoplasmic vesicle;Nucleoplasm	NA	Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.	Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex that contains FZR1/CDH1 during G1 phase leading to its degradation by the proteasome. Ubiquitinated by a SCF complex containing BTRC and FBXW11 during S phase leading to its degradation by the proteasome. Deubiquitination by USP17L2/DUB3 leads to its stabilization.;Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation.;CDC25A is phosphorylated by PIM2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);CDC25A is phosphorylated by PIM1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);CDC25A is phosphorylated by CHEK2	Belongs to the MPI phosphatase family.	Cell cycle;Progesterone-mediated oocyte maturation;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Activation of ATR in response to replication stress;Polo-like kinase mediated events;Cyclin E associated events during G1/S transition;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A:Cdk2-associated events at S phase entry;Ub-specific processing proteases;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Transcription of E2F targets under negative control by DREAM complex	PE1	3
+NX_P30305	M-phase inducer phosphatase 2	580	64987	6	0	Cytoplasmic vesicle;Spindle pole;Spindle;Centrosome	NA	Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.	Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.	Belongs to the MPI phosphatase family.	MAPK signaling pathway;Cell cycle;Progesterone-mediated oocyte maturation;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A:Cdk2-associated events at S phase entry;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	PE1	20
+NX_P30307	M-phase inducer phosphatase 3	473	53365	6.34	0	Nucleus speckle;Nucleus	NA	Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.	Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.;CDC25C is phosphorylated by PLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);CDC25C is phosphorylated by PLK4;CDC25C is phosphorylated by PLK3 (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254);CDC25C is phosphorylated by PIM1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the MPI phosphatase family.	Cell cycle;Oocyte meiosis;Progesterone-mediated oocyte maturation;Activation of ATR in response to replication stress;Polo-like kinase mediated events;Cyclin A/B1/B2 associated events during G2/M transition;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;RHO GTPases activate PKNs;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	PE1	5
+NX_P30405	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	207	22040	9.49	0	Mitochondrion matrix;Mitochondrion	NA	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.	Deacetylated at Lys-167 by SIRT3.	Belongs to the cyclophilin-type PPIase family.	Toxoplasmosis	PE1	10
+NX_P30408	Transmembrane 4 L6 family member 1	202	21632	4.88	4	Membrane;Cell membrane	NA	NA	NA	Belongs to the L6 tetraspanin family.	NA	PE1	3
+NX_P30411	B2 bradykinin receptor	391	44461	8.5	7	Cell membrane	NA	Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Regulation of actin cytoskeleton;Endocrine and other factor-regulated calcium reabsorption;Chagas disease (American trypanosomiasis);G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	14
+NX_P30414	NK-tumor recognition protein	1462	165677	10.01	0	Nucleoplasm;Cytosol;Cell membrane	NA	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688).	NA	NA	NA	PE1	3
+NX_P30419	Glycylpeptide N-tetradecanoyltransferase 1	496	56806	7.65	0	Membrane;Cytoplasm;Cytosol;Cell membrane	NA	Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.	NA	Belongs to the NMT family.	Activation, myristolyation of BID and translocation to mitochondria;Inactivation, recovery and regulation of the phototransduction cascade;Late Phase of HIV Life Cycle	PE1	17
+NX_P30511	HLA class I histocompatibility antigen, alpha chain F	346	39062	5.37	1	Early endosome membrane;Lysosome membrane;Cell membrane	NA	Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors (PubMed:28636952). Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production (PubMed:27455421). Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions (PubMed:24018270). May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683). May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).	N-glycosylated.	Belongs to the MHC class I family.	Endocytosis;Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Type I diabetes mellitus;HTLV-I infection;Herpes simplex infection;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;Viral myocarditis;ER-Phagosome pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Endosomal/Vacuolar pathway;Interferon gamma signaling;Interferon alpha/beta signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC	PE1	6
+NX_P30518	Vasopressin V2 receptor	371	40279	9.49	7	Cell membrane	Nephrogenic syndrome of inappropriate antidiuresis;Diabetes insipidus, nephrogenic, X-linked	Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.	NA	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	Neuroactive ligand-receptor interaction;Vasopressin-regulated water reabsorption;G alpha (s) signalling events;Vasopressin regulates renal water homeostasis via Aquaporins;Vasopressin-like receptors;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	PE1	X
+NX_P30519	Heme oxygenase 2	316	36033	5.31	0	Endoplasmic reticulum;Cytosol;Microsome;Cytoplasmic vesicle	NA	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.	NA	Belongs to the heme oxygenase family.	Porphyrin and chlorophyll metabolism;Mineral absorption;Iron uptake and transport;Heme degradation;Neutrophil degranulation	PE1	16
+NX_P30520	Adenylosuccinate synthetase isozyme 2	456	50097	6.13	0	Cytoplasm;Cytosol;Mitochondrion;Cell membrane	NA	Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.	NA	Belongs to the adenylosuccinate synthetase family.	Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.;Purine metabolism;Alanine, aspartate and glutamate metabolism;Metabolic pathways;Purine ribonucleoside monophosphate biosynthesis	PE1	1
+NX_P30530	Tyrosine-protein kinase receptor UFO	894	98337	5.23	1	Cytoplasmic vesicle;Cell membrane;Cytoskeleton	NA	(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.;(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.;Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.	Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion.;Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.;AXL is phosphorylated by TYRO3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.	VEGFA-VEGFR2 Pathway	PE1	19
+NX_P30531	Sodium- and chloride-dependent GABA transporter 1	599	67074	8.39	12	Membrane;Presynapse;Mitochondrion;Cell membrane	Myoclonic-atonic epilepsy	Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily.	GABAergic synapse;Na+/Cl- dependent neurotransmitter transporters;Reuptake of GABA	PE1	3
+NX_P30532	Neuronal acetylcholine receptor subunit alpha-5	468	53054	6.52	4	Postsynaptic cell membrane;Focal adhesion;Cell membrane	NA	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.	Neuroactive ligand-receptor interaction;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly calcium permeable nicotinic acetylcholine receptors	PE1	15
+NX_P30533	Alpha-2-macroglobulin receptor-associated protein	357	41466	8.73	0	Golgi apparatus lumen;Cell surface;Endoplasmic reticulum;Endoplasmic reticulum-Golgi intermediate compartment lumen;Rough endoplasmic reticulum lumen;cis-Golgi network;Endosome lumen	Myopia 23, autosomal recessive	Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.	N-glycosylated.	Belongs to the alpha-2-MRAP family.	NA	PE1	4
+NX_P30536	Translocator protein	169	18828	9.43	5	Mitochondrion membrane;Cytoplasmic vesicle;Cytosol;Mitochondrion	NA	Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).	NA	Belongs to the TspO/BZRP family.	Neuroactive ligand-receptor interaction;HTLV-I infection;Pregnenolone biosynthesis	PE1	22
+NX_P30542	Adenosine receptor A1	326	36512	8.9	7	Cell membrane	NA	Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Adenosine P1 receptors	PE1	1
+NX_P30550	Gastrin-releasing peptide receptor	384	43199	8.78	7	Cell membrane	NA	Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	X
+NX_P30556	Type-1 angiotensin II receptor	359	41061	9.44	7	Cytoplasmic vesicle;Cell membrane	Renal tubular dysgenesis	Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	C-terminal Ser or Thr residues may be phosphorylated.;AGTR1 is phosphorylated by GRK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;Renin-angiotensin system;Peptide ligand-binding receptors;G alpha (q) signalling events;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	3
+NX_P30559	Oxytocin receptor	389	42772	9.63	7	Cell membrane	NA	Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Vasopressin-like receptors	PE1	3
+NX_P30566	Adenylosuccinate lyase	484	54889	6.68	0	Cytosol	Adenylosuccinase deficiency	Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.	NA	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.;Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.;Purine metabolism;Alanine, aspartate and glutamate metabolism;Metabolic pathways;Purine ribonucleoside monophosphate biosynthesis	PE1	22
+NX_P30613	Pyruvate kinase PKLR	574	61830	7.65	0	Golgi apparatus;Cytosol	Pyruvate kinase hyperactivity;Pyruvate kinase deficiency of red cells	Plays a key role in glycolysis.	NA	Belongs to the pyruvate kinase family.	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.;Glycolysis / Gluconeogenesis;Purine metabolism;Pyruvate metabolism;Metabolic pathways;Insulin signaling pathway;Type II diabetes mellitus;Maturity onset diabetes of the young;Glycolysis;Regulation of gene expression in beta cells;ChREBP activates metabolic gene expression	PE1	1
+NX_P30622	CAP-Gly domain-containing linker protein 1	1438	162246	5.29	0	Cytoplasm;Cytoplasmic vesicle membrane;Ruffle;Cytosol;Cytoskeleton	NA	Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.	Phosphorylated. Phosphorylation induces conformational changes by increasing the affinity of the N-terminus for C-terminus, resulting in inhibition of its function thus decreasing its binding to microtubules and DCTN1. Exhibits a folded, autoinhibited conformation when phosphorylated and an open conformation when dephosphorylated with increased binding affinity to microtubules and DCTN1. Phosphorylation regulates its recruitment to tyrosinated microtubules and the recruitment of vesicular cargo to microtubules in neurons (By similarity). Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules (PubMed:12231510).;CLIP1 is phosphorylated by MAPK3	NA	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;RHO GTPases activate IQGAPs;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	12
+NX_P30626	Sorcin	198	21676	5.32	0	Cytoplasm;Nucleoplasm;Cytosol;Sarcoplasmic reticulum membrane	NA	Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.	NA	NA	Ion transport by P-type ATPases;Stimuli-sensing channels;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis	PE1	7
+NX_P30679	Guanine nucleotide-binding protein subunit alpha-15	374	43568	8.74	0	NA	NA	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.	NA	Belongs to the G-alpha family. G(q) subfamily.	Calcium signaling pathway;Chagas disease (American trypanosomiasis);Amoebiasis;G alpha (q) signalling events;ADP signalling through P2Y purinoceptor 1;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion;Acetylcholine regulates insulin secretion	PE1	19
+NX_P30711	Glutathione S-transferase theta-1	240	27335	7.01	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.	NA	Belongs to the GST superfamily. Theta family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation	PE1	22
+NX_P30740	Leukocyte elastase inhibitor	379	42742	5.9	0	Cytoplasm;Cytosol;Cytoplasmic granule;Secreted	NA	Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651).	NA	Belongs to the serpin family. Ov-serpin subfamily.	Amoebiasis;Neutrophil degranulation	PE1	6
+NX_P30793	GTP cyclohydrolase 1	250	27903	8.73	0	Cytoplasm;Nucleus membrane;Nucleoplasm;Cytosol;Nucleus	Dystonia, dopa-responsive;Hyperphenylalaninemia, BH4-deficient, B	Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence.;Is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.	Phosphorylated by casein kinase II at Ser-81 in HAECs during oscillatory shear stress; phosphorylation at Ser-81 results in increased enzyme activity.	Belongs to the GTP cyclohydrolase I family.	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.;Folate biosynthesis;Metabolic pathways;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	PE1	14
+NX_P30825	High affinity cationic amino acid transporter 1	629	67638	5.29	14	Cell membrane	NA	High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.	Amino acid transport across the plasma membrane	PE1	13
+NX_P30837	Aldehyde dehydrogenase X, mitochondrial	517	57206	6.36	0	Mitochondrion matrix;Cytoplasmic vesicle;Nucleoplasm;Mitochondrion	NA	ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.	NA	Belongs to the aldehyde dehydrogenase family.	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.;Glycolysis / Gluconeogenesis;Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Lysine degradation;Arginine and proline metabolism;Histidine metabolism;Tryptophan metabolism;beta-Alanine metabolism;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Ethanol oxidation	PE1	9
+NX_P30838	Aldehyde dehydrogenase, dimeric NADP-preferring	453	50395	6.11	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).	NA	Belongs to the aldehyde dehydrogenase family.	Glycolysis / Gluconeogenesis;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;beta-Alanine metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Phase I - Functionalization of compounds	PE1	17
+NX_P30872	Somatostatin receptor type 1	391	42686	8.68	7	Cell membrane	NA	Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	14
+NX_P30874	Somatostatin receptor type 2	369	41333	9.15	7	Cytoplasm;Cytosol;Cell membrane	NA	Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.	Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity).	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Gastric acid secretion;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	17
+NX_P30876	DNA-directed RNA polymerase II subunit RPB2	1174	133897	6.44	0	Nucleoplasm;Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).	NA	Belongs to the RNA polymerase beta chain family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Huntington's disease;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;MicroRNA (miRNA) biogenesis;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	4
+NX_P30926	Neuronal acetylcholine receptor subunit beta-4	498	56380	8.64	4	Postsynaptic cell membrane;Endoplasmic reticulum;Cell junction;Cell membrane	NA	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily.	Neuroactive ligand-receptor interaction;Cholinergic synapse;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly sodium permeable acetylcholine nicotinic receptors;Highly calcium permeable nicotinic acetylcholine receptors;Neutrophil degranulation	PE1	15
+NX_P30939	5-hydroxytryptamine receptor 1F	366	41709	9.09	7	Cell membrane	NA	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Serotonin receptors	PE1	3
+NX_P30953	Olfactory receptor 1E1	314	35264	7.98	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	17
+NX_P30954	Olfactory receptor 10J1	320	35925	9.29	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_P30968	Gonadotropin-releasing hormone receptor	328	37731	9.56	7	Cell membrane	Hypogonadotropic hypogonadism 7 with or without anosmia	Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.;May act as an inhibitor of GnRH-R signaling.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;GnRH signaling pathway;G alpha (q) signalling events;Hormone ligand-binding receptors	PE1	4
+NX_P30988	Calcitonin receptor	474	55329	8.6	7	Cell membrane	NA	Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase (PubMed:7476993). Does not undergo receptor internalization following ligand binding (PubMed:7476993).;This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.	NA	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;Osteoclast differentiation;G alpha (s) signalling events;Calcitonin-like ligand receptors	PE1	7
+NX_P30989	Neurotensin receptor type 1	418	46259	9.46	7	Membrane raft;Cell membrane	NA	G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197).	N-glycosylated.;Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment.	Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	20
+NX_P30990	Neurotensin/neuromedin N	170	19795	6.59	0	Secreted;Secretory vesicle	NA	Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.	NA	Belongs to the neurotensin family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	12
+NX_P31025	Lipocalin-1	176	19250	5.39	0	Secreted	NA	Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.	NA	Belongs to the calycin superfamily. Lipocalin family.	Transport of fatty acids	PE1	9
+NX_P31040	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	664	72692	7.06	0	Mitochondrion inner membrane;Mitochondrion;Nucleolus	Leigh syndrome;Paragangliomas 5;Mitochondrial complex II deficiency;Cardiomyopathy, dilated 1GG	Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225).	Acetylated. Deacetylated by SIRT3.;Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation.	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.	Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.;Citrate cycle (TCA cycle);Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Citric acid cycle (TCA cycle)	PE1	5
+NX_P31146	Coronin-1A	461	51026	6.25	0	Phagosome membrane;Cytosol;Cell cortex;Cytoskeleton	Immunodeficiency 8	May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.	Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.;Phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.;CORO1A is phosphorylated by CDK5	Belongs to the WD repeat coronin family.	Phagosome;Tuberculosis	PE1	16
+NX_P31150	Rab GDP dissociation inhibitor alpha	447	50583	5	0	trans-Golgi network;Cytoplasm;Cytoplasmic vesicle	Mental retardation, X-linked 41	Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.	NA	Belongs to the Rab GDI family.	Rho GTPase cycle;RAB GEFs exchange GTP for GDP on RABs	PE1	X
+NX_P31151	Protein S100-A7	101	11471	6.27	0	Cytoplasm;Secreted	NA	NA	NA	Belongs to the S-100 family.	Neutrophil degranulation;Metal sequestration by antimicrobial proteins	PE1	1
+NX_P31152	Mitogen-activated protein kinase 4	587	65922	5.25	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Midbody;Nucleus	NA	Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).	Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK6/MAPK4 signaling	PE1	18
+NX_P31153	S-adenosylmethionine synthase isoform type-2	395	43661	6.02	0	Nucleoplasm;Cytosol	NA	Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.	NA	Belongs to the AdoMet synthase family.	Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.;Cysteine and methionine metabolism;Metabolic pathways;Methylation	PE1	2
+NX_P31213	3-oxo-5-alpha-steroid 4-dehydrogenase 2	254	28393	9.47	4	Microsome membrane;Endoplasmic reticulum membrane	Pseudovaginal perineoscrotal hypospadias	Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	NA	Belongs to the steroid 5-alpha reductase family.	Steroid hormone biosynthesis;Prostate cancer;Androgen biosynthesis	PE1	2
+NX_P31249	Homeobox protein Hox-D3	432	45730	8.98	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	2
+NX_P31260	Homeobox protein Hox-A10	410	42414	8.63	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	7
+NX_P31267	Homeobox protein Hox-A6	233	26339	9.18	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	NA	PE1	7
+NX_P31268	Homeobox protein Hox-A7	230	25355	5.26	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	NA	PE1	7
+NX_P31269	Homeobox protein Hox-A9	272	30172	8.8	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.	Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.	Belongs to the Abd-B homeobox family.	NA	PE1	7
+NX_P31270	Homeobox protein Hox-A11	313	34486	8.91	0	Nucleoplasm;Nucleus	Radioulnar synostosis with amegakaryocytic thrombocytopenia 1	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	7
+NX_P31271	Homeobox protein Hox-A13	388	39727	9.24	0	Nucleoplasm;Nucleus;Cytoskeleton	Guttmacher syndrome;Hand-foot-genital syndrome	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.;Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	7
+NX_P31273	Homeobox protein Hox-C8	242	27755	6.56	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	NA	PE1	12
+NX_P31274	Homeobox protein Hox-C9	260	29248	9.14	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	12
+NX_P31275	Homeobox protein Hox-C12	282	30171	8.93	0	Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	12
+NX_P31276	Homeobox protein Hox-C13	330	35379	9.11	0	Nucleus	Ectodermal dysplasia 9, hair/nail type	Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity).	NA	Belongs to the Abd-B homeobox family.	NA	PE1	12
+NX_P31277	Homeobox protein Hox-D11	338	35197	9.02	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	2
+NX_P31314	T-cell leukemia homeobox protein 1	330	34365	9.53	0	Nucleoplasm;Nucleus	NA	Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.	NA	NA	NA	PE1	10
+NX_P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	381	43073	5.53	0	Cell membrane	NA	Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.	The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.	Belongs to the cAMP-dependent kinase regulatory chain family.	Apoptosis;Insulin signaling pathway;Factors involved in megakaryocyte development and platelet production;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;CREB1 phosphorylation through the activation of Adenylate Cyclase	PE1	7
+NX_P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	418	46302	4.82	0	Cytoplasm;Mitochondrion;Cell membrane	NA	Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.	Phosphorylated by the activated catalytic chain.	Belongs to the cAMP-dependent kinase regulatory chain family.	Apoptosis;Insulin signaling pathway;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Factors involved in megakaryocyte development and platelet production;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Recruitment of NuMA to mitotic centrosomes;CREB1 phosphorylation through the activation of Adenylate Cyclase;AURKA Activation by TPX2	PE1	7
+NX_P31327	Carbamoyl-phosphate synthase [ammonia], mitochondrial	1500	164939	6.3	0	Mitochondrion;Nucleolus	Carbamoyl phosphate synthetase 1 deficiency;Pulmonary hypertension, neonatal	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.	Undergoes proteolytic cleavage in the C-terminal region corresponding to the loss of approximately 12 AA residues from the C-terminus.;Glutarylated. Glutarylation levels increase during fasting. Deglutarylated by SIRT5 at Lys-55, Lys-219, Lys-412, Lys-889, Lys-892, Lys-915, Lys-1360 and Lys-1486, leading to activation.;Succinylated at Lys-287 and Lys-1291. Desuccinylated at Lys-1291 by SIRT5, leading to activation (By similarity).	NA	Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;Nitrogen metabolism;Metabolic pathways;Urea cycle	PE1	2
+NX_P31350	Ribonucleoside-diphosphate reductase subunit M2	389	44878	5.28	0	Cytoplasm;Cytosol	NA	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.	Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling.	Belongs to the ribonucleoside diphosphate reductase small chain family.	Genetic information processing; DNA replication.;Purine metabolism;Pyrimidine metabolism;Glutathione metabolism;Metabolic pathways;p53 signaling pathway;G1/S-Specific Transcription;Interconversion of nucleotide di- and triphosphates;Transcriptional Regulation by E2F6	PE1	2
+NX_P31358	CAMPATH-1 antigen	61	6614	8	0	Cell membrane	NA	May play a role in carrying and orienting carbohydrate, as well as having a more specific role.	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	1
+NX_P31371	Fibroblast growth factor 9	208	23441	7.06	0	Secreted	Multiple synostoses syndrome 3	Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.	N-glycosylated.;Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step.	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR1;Signaling by activated point mutants of FGFR3;FGFR4 ligand binding and activation;FGFR3c ligand binding and activation;FGFR1c ligand binding and activation;FGFR2c ligand binding and activation;FGFR3 mutant receptor activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;Phospholipase C-mediated cascade, FGFR4;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;FGFR3b ligand binding and activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;Signaling by FGFR3 point mutants in cancer	PE1	13
+NX_P31391	Somatostatin receptor type 4	388	42003	9.09	7	Cell membrane	NA	Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE2	20
+NX_P31415	Calsequestrin-1	396	45160	4.03	0	Mitochondrion;Mitochondrion matrix;Sarcoplasmic reticulum;Endoplasmic reticulum;Nucleoplasm;Sarcoplasmic reticulum lumen;Sarcoplasmic reticulum membrane	Myopathy, vacuolar, with CASQ1 aggregates;Myopathy, tubular aggregate, 1	Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:28895244). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (PubMed:28895244). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (PubMed:27185316).	N-glycosylated.	Belongs to the calsequestrin family.	Stimuli-sensing channels;Ion homeostasis	PE1	1
+NX_P31431	Syndecan-4	198	21642	4.39	1	Membrane;Golgi apparatus;Secreted;Cell membrane	NA	Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).	Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.	Belongs to the syndecan proteoglycan family.	ECM-receptor interaction;Cell adhesion molecules (CAMs);Malaria;Retinoid metabolism and transport;HS-GAG biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Syndecan interactions;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Cell surface interactions at the vascular wall;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	20
+NX_P31483	Nucleolysin TIA-1 isoform p40	386	42963	7.62	0	Nucleoplasm;Cytosol;Stress granule;Nucleus	Welander distal myopathy	Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.	TIA1 is phosphorylated by FASTK (Phosphoserine:PTM-0253)	NA	FGFR2 alternative splicing	PE1	2
+NX_P31512	Dimethylaniline monooxygenase [N-oxide-forming] 4	558	63343	8.74	1	Microsome membrane;Cytoplasmic vesicle;Cytosol;Endoplasmic reticulum membrane	NA	This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.	NA	Belongs to the FMO family.	Drug metabolism - cytochrome P450	PE1	1
+NX_P31513	Dimethylaniline monooxygenase [N-oxide-forming] 3	532	60033	7.9	1	Microsome membrane;Endoplasmic reticulum membrane	Trimethylaminuria	Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269).	NA	Belongs to the FMO family.	Drug metabolism - cytochrome P450;FMO oxidises nucleophiles;Defective FMO3 causes Trimethylaminuria (TMAU)	PE1	1
+NX_P31629	Transcription factor HIVEP2	2446	269053	6.5	0	Nucleoplasm;Nucleus	Mental retardation, autosomal dominant 43	This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.	NA	NA	NA	PE1	6
+NX_P31639	Sodium/glucose cotransporter 2	672	72897	7.45	11	Membrane	Renal glucosuria	Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.;Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.	NA	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Cellular hexose transport;Defective SLC5A2 causes renal glucosuria (GLYS1)	PE1	16
+NX_P31641	Sodium- and chloride-dependent taurine transporter	620	69830	7.37	12	Cytosol;Cell junction;Cell membrane	NA	Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.	Down-regulated upon Ser-322 phosphorylation.	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.	Amino acid transport across the plasma membrane;Na+/Cl- dependent neurotransmitter transporters	PE1	3
+NX_P31644	Gamma-aminobutyric acid receptor subunit alpha-5	462	52146	9.22	4	Postsynaptic cell membrane;Cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;GABA receptor activation	PE1	15
+NX_P31645	Sodium-dependent serotonin transporter	630	70325	5.89	12	Golgi apparatus;Cell membrane;Endosome membrane;Endomembrane system;Focal adhesion;Synapse;Cytoplasmic vesicle	NA	Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.	Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation. Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity.;Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms.	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.	Serotonin clearance from the synaptic cleft	PE1	17
+NX_P31689	DnaJ homolog subfamily A member 1	397	44868	6.65	0	Cytoplasm;Mitochondrion;Microsome;Cell membrane;Membrane;Cytosol;Perinuclear region;Nucleus;Cytoskeleton	NA	Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).	NA	NA	Protein processing in endoplasmic reticulum;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	9
+NX_P31749	RAC-alpha serine/threonine-protein kinase	480	55686	5.75	0	Cytoplasm;Cell membrane;Nucleoplasm;Nucleus;Cytoskeleton	Breast cancer;Proteus syndrome;Colorectal cancer;Cowden syndrome 6	AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53.;AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.	Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Activated TNK2 phosphorylates it on Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA. This phosphorylated form localizes to the cell membrane, where it is targeted by PDPK1 and PDPK2 for further phosphorylations on Thr-308 and Ser-473 leading to its activation. Ser-473 phosphorylation by mTORC2 favors Thr-308 phosphorylation by PDPK1. Phosphorylated at Thr-308 and Ser-473 by IKBKE and TBK1. Ser-473 phosphorylation is enhanced by interaction with AGAP2 isoform 2 (PIKE-A). Ser-473 phosphorylation is enhanced in focal cortical dysplasias with Taylor-type balloon cells. Ser-473 phosphorylation is enhanced by signaling through activated FLT3. Dephosphorylated at Thr-308 and Ser-473 by PP2A phosphatase. The phosphorylated form of PPP2R5B is required for bridging AKT1 with PP2A phosphatase. Ser-473 is dephosphorylated by CPPED1, leading to termination of signaling.;Acetylated on Lys-14 and Lys-20 by the histone acetyltransferases EP300 and KAT2B. Acetylation results in reduced phosphorylation and inhibition of activity. Deacetylated at Lys-14 and Lys-20 by SIRT1. SIRT1-mediated deacetylation relieves the inhibition.;O-GlcNAcylation at Thr-305 and Thr-312 inhibits activating phosphorylation at Thr-308 via disrupting the interaction between AKT1 and PDPK1. O-GlcNAcylation at Ser-473 also probably interferes with phosphorylation at this site.;Ubiquitinated via 'Lys-48'-linked polyubiquitination by ZNRF1, leading to its degradation by the proteasome (By similarity). Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced 'Lys-63'-linked AKT1 ubiquitination is critical for phosphorylation and activation. When ubiquitinated, it translocates to the plasma membrane, where it becomes phosphorylated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome. Also ubiquitinated by TRIM13 leading to its proteasomal degradation. Phosphorylated, undergoes 'Lys-48'-linked polyubiquitination preferentially at Lys-284 catalyzed by MUL1, leading to its proteasomal degradation.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;mTOR signaling pathway;Apoptosis;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Tight junction;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Adipocytokine signaling pathway;Carbohydrate digestion and absorption;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Translocation of SLC2A4 (GLUT4) to the plasma membrane;PIP3 activates AKT signaling;G beta:gamma signalling through PI3Kgamma;VEGFR2 mediated vascular permeability;CD28 dependent PI3K/Akt signaling;Cyclin E associated events during G1/S transition;TP53 Regulates Metabolic Genes;Activation of BAD and translocation to mitochondria;Deactivation of the beta-catenin transactivating complex;Cyclin A:Cdk2-associated events at S phase entry;AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;mTOR signalling;eNOS activation;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;CTLA4 inhibitory signaling;Integrin alphaIIb beta3 signaling;AKT phosphorylates targets in the cytosol;Downregulation of ERBB2:ERBB3 signaling;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Negative regulation of the PI3K/AKT network;AKT-mediated inactivation of FOXO1A;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Association with Co-factors;RAB GEFs exchange GTP for GDP on RABs;Interleukin-4 and Interleukin-13 signaling;Regulation of PTEN stability and activity;RUNX2 regulates genes involved in cell migration;Negative regulation of NOTCH4 signaling;Extra-nuclear estrogen signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling;Regulation of localization of FOXO transcription factors	PE1	14
+NX_P31751	RAC-beta serine/threonine-protein kinase	481	55769	5.98	0	Cytoplasm;Cell membrane;Early endosome;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	Diabetes mellitus, non-insulin-dependent;Hypoinsulinemic hypoglycemia with hemihypertrophy	AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development.;One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on 'Ser-197' during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Phosphorylates CLK2 on 'Thr-343'.	Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced 'Lys-63'-linked AKT2 ubiquitination. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.;Phosphorylation on Thr-309 and Ser-474 is required for full activity.;O-GlcNAcylation at Thr-306 and Thr-313 inhibits activating phosphorylation at Thr-309 via disrupting the interaction between AKT and PDK1.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;mTOR signaling pathway;Apoptosis;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Tight junction;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Adipocytokine signaling pathway;Carbohydrate digestion and absorption;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Translocation of SLC2A4 (GLUT4) to the plasma membrane;PIP3 activates AKT signaling;G beta:gamma signalling through PI3Kgamma;VEGFR2 mediated vascular permeability;CD28 dependent PI3K/Akt signaling;Cyclin E associated events during G1/S transition;TP53 Regulates Metabolic Genes;Activation of BAD and translocation to mitochondria;Deactivation of the beta-catenin transactivating complex;Cyclin A:Cdk2-associated events at S phase entry;AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;CTLA4 inhibitory signaling;Activation of AKT2;AKT phosphorylates targets in the cytosol;Downregulation of ERBB2:ERBB3 signaling;Inhibition of TSC complex formation by PKB;PDE3B signalling;Negative regulation of the PI3K/AKT network;AKT-mediated inactivation of FOXO1A;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Association with Co-factors;RAB GEFs exchange GTP for GDP on RABs;Regulation of PTEN stability and activity;RUNX2 regulates genes involved in cell migration;Estrogen-dependent nuclear events downstream of ESR-membrane signaling;Regulation of localization of FOXO transcription factors	PE1	19
+NX_P31785	Cytokine receptor common subunit gamma	369	42287	5.9	1	Cell surface;Cytoplasmic vesicle;Cell membrane	Severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative;X-linked combined immunodeficiency	Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770).	IL2RG is phosphorylated by JAK3 (Phosphotyrosine:PTM-0255)	Belongs to the type I cytokine receptor family. Type 5 subfamily.	Cytokine-cytokine receptor interaction;Endocytosis;Jak-STAT signaling pathway;Measles;HTLV-I infection;Primary immunodeficiency;RAF/MAP kinase cascade;Interleukin-7 signaling;Interleukin receptor SHC signaling;Interleukin-4 and Interleukin-13 signaling;Interleukin-15 signaling;Interleukin-9 signaling;Interleukin-2 signaling;Interleukin-21 signaling	PE1	X
+NX_P31930	Cytochrome b-c1 complex subunit 1, mitochondrial	480	52646	5.94	0	Cytosol;Mitochondrion inner membrane;Mitochondrion	NA	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.	NA	Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport	PE1	3
+NX_P31937	3-hydroxyisobutyrate dehydrogenase, mitochondrial	336	35329	8.38	0	Mitochondrion	NA	NA	NA	Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.	Amino-acid degradation; L-valine degradation.;Valine, leucine and isoleucine degradation;Metabolic pathways;Branched-chain amino acid catabolism	PE1	7
+NX_P31939	Bifunctional purine biosynthesis protein PURH	592	64616	6.27	0	Cytosol;Cell membrane	AICAR transformylase/IMP cyclohydrolase deficiency	Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.;Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).	NA	Belongs to the PurH family.	Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.;Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.;Purine metabolism;One carbon pool by folate;Metabolic pathways;Purine ribonucleoside monophosphate biosynthesis	PE1	2
+NX_P31941	DNA dC->dU-editing enzyme APOBEC-3A	199	23012	6.34	0	Cytoplasm;Nucleus	NA	DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	mRNA Editing: C to U Conversion;Formation of the Editosome	PE1	22
+NX_P31942	Heterogeneous nuclear ribonucleoprotein H3	346	36926	6.37	0	Nucleoplasm;Nucleus	NA	Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.	NA	NA	NA	PE1	10
+NX_P31943	Heterogeneous nuclear ribonucleoprotein H	449	49229	5.89	0	Nucleoplasm	NA	This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).	NA	NA	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;FGFR2 alternative splicing	PE1	5
+NX_P31944	Caspase-14	242	27680	5.44	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	Ichthyosis, congenital, autosomal recessive 12	Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).	Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts on the precursor to yield the p17/p10 mature form (PubMed:22825846). Initially, cleavage between Ile-152 and Lys-153 has been proposed to yield the large and small subunits of the active enzyme (PubMed:12200134).	Belongs to the peptidase C14A family.	Formation of the cornified envelope	PE1	19
+NX_P31946	14-3-3 protein beta/alpha	246	28082	4.76	0	Vacuole membrane;Cytoplasm;Melanosome	NA	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.	The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.;YWHAB is phosphorylated by IGF1R (Phosphotyrosine:PTM-0255)	Belongs to the 14-3-3 family.	Cell cycle;Oocyte meiosis;Neurotrophin signaling pathway;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Signaling by Hippo;Negative regulation of MAPK pathway;RAF activation;MAP2K and MAPK activation;TP53 Regulates Metabolic Genes;Activation of BAD and translocation to mitochondria;ARMS-mediated activation;mTOR signalling;mTORC1-mediated signalling;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;RHO GTPases activate PKNs;Frs2-mediated activation;Rap1 signalling;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Regulation of localization of FOXO transcription factors	PE1	20
+NX_P31947	14-3-3 protein sigma	248	27774	4.68	0	Cytoplasm;Secreted;Nucleus	NA	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.;P53-regulated inhibitor of G2/M progression.	Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.	Belongs to the 14-3-3 family.	Cell cycle;p53 signaling pathway;Aldosterone-regulated sodium reabsorption;Translocation of SLC2A4 (GLUT4) to the plasma membrane;TP53 Regulates Metabolic Genes;Activation of BAD and translocation to mitochondria;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;RHO GTPases activate PKNs;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Regulation of localization of FOXO transcription factors	PE1	1
+NX_P31948	Stress-induced-phosphoprotein 1	543	62639	6.4	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).	NA	NA	Prion diseases;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	11
+NX_P31949	Protein S100-A11	105	11740	6.56	0	Cytoplasm;Nucleus	NA	Facilitates the differentiation and the cornification of keratinocytes.	Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.	Belongs to the S-100 family.	Neutrophil degranulation	PE1	1
+NX_P31994	Low affinity immunoglobulin gamma Fc region receptor II-b	310	34044	5.74	1	Cell membrane	Systemic lupus erythematosus	Fails to mediate endocytosis or phagocytosis.;Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor.;Does not trigger phagocytosis.	Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.	NA	Phagosome;Osteoclast differentiation;B cell receptor signaling pathway;Fc gamma R-mediated phagocytosis;Staphylococcus aureus infection;Tuberculosis;Measles;Systemic lupus erythematosus;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	1
+NX_P31995	Low affinity immunoglobulin gamma Fc region receptor II-c	323	35578	6.4	1	Cytoplasm;Cell membrane	NA	Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.	Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.	NA	NA	PE1	1
+NX_P31997	Carcinoembryonic antigen-related cell adhesion molecule 8	349	38154	6.95	0	Cell surface;Cell membrane	NA	Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).	Glycosylated.	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall;Fibronectin matrix formation;Neutrophil degranulation	PE1	19
+NX_P32004	Neural cell adhesion molecule L1	1257	140003	5.84	1	Cell membrane;Growth cone;Nucleoplasm;Axon;Dendrite	Mental retardation, aphasia, shuffling gait, and adducted thumbs syndrome;Hydrocephalus due to stenosis of the aqueduct of Sylvius;Agenesis of the corpus callosum, X-linked, partial	Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.	L1CAM is phosphorylated by EPHB2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.	Axon guidance;Cell adhesion molecules (CAMs);Signal transduction by L1;Interaction between L1 and Ankyrins;Recycling pathway of L1;Basigin interactions;L1CAM interactions	PE1	X
+NX_P32019	Type II inositol 1,4,5-trisphosphate 5-phosphatase	993	112852	5.37	0	Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment;Phagosome membrane;Membrane;Early endosome membrane;Cytosol	NA	Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.	Isoprenylation at Cys-990 may be required for localization at the membrane.;May be proteolytically cleaved after Lys-320 as inferred from N-terminal protein sequence of the 75 kda form.	Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Rho GTPase cycle;Synthesis of IP2, IP, and Ins in the cytosol;Synthesis of IP3 and IP4 in the cytosol	PE1	1
+NX_P32119	Peroxiredoxin-2	198	21892	5.66	0	Cytoplasm	NA	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).	The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.	Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.	Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	PE1	19
+NX_P32121	Beta-arrestin-2	409	46106	7.59	0	Cytoplasm;Cell membrane;Clathrin-coated pit;Cytoplasmic vesicle;Nucleus	NA	Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3.	The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and signaling. Ubiquitination appears to occur GPCR-specific. Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and subsequently promotes association with USP33. Stimulation of a class B GPCR promotes a sustained ubiquitination.;Hydroxylation by PHD2 modulates the rate of internalization by slowing down recruitment to the plasma membrane and inhibiting subsequent co-internalization with class A receptors.;Phosphorylated at Thr-382 in the cytoplasm; probably dephosphorylated at the plasma membrane. The phosphorylation does not regulate internalization and recycling of ADRB2, interaction with clathrin or AP2B1.	Belongs to the arrestin family.	MAPK signaling pathway;Chemokine signaling pathway;Endocytosis;Dopaminergic synapse;Olfactory transduction;Phototransduction;G alpha (s) signalling events;Activation of SMO;MAP2K and MAPK activation;Thrombin signalling through proteinase activated receptors (PARs);WNT5A-dependent internalization of FZD4;Activated NOTCH1 Transmits Signal to the Nucleus;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	17
+NX_P32189	Glycerol kinase	559	61245	6.12	0	Mitochondrion outer membrane;Cytoplasm	Glycerol kinase deficiency	Key enzyme in the regulation of glycerol uptake and metabolism.	NA	Belongs to the FGGY kinase family.	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.;Glycerolipid metabolism;Metabolic pathways;PPAR signaling pathway;Triglyceride biosynthesis	PE1	X
+NX_P32238	Cholecystokinin receptor type A	428	47841	9.37	7	Cell membrane	NA	Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Pancreatic secretion;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	4
+NX_P32239	Gastrin/cholecystokinin type B receptor	447	48419	10.03	7	Cell membrane	NA	Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.;Is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Gastric acid secretion;Peptide ligand-binding receptors;G alpha (q) signalling events;Gastrin-CREB signalling pathway via PKC and MAPK	PE1	11
+NX_P32241	Vasoactive intestinal polypeptide receptor 1	457	51547	8.52	7	Cell membrane	NA	This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.	NA	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Glucagon-type ligand receptors	PE1	3
+NX_P32242	Homeobox protein OTX1	354	37327	9.41	0	Cytosol;Nucleus speckle;Nucleus	NA	Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.	NA	Belongs to the paired homeobox family. Bicoid subfamily.	NA	PE1	2
+NX_P32243	Homeobox protein OTX2	289	31636	9.4	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	Retinal dystrophy, early-onset, with or without pituitary dysfunction;Microphthalmia, syndromic, 5;Pituitary hormone deficiency, combined, 6	Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.	NA	Belongs to the paired homeobox family. Bicoid subfamily.	NA	PE1	14
+NX_P32245	Melanocortin receptor 4	332	36943	7.88	7	Cell membrane	Obesity	Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (s) signalling events	PE1	18
+NX_P32246	C-C chemokine receptor type 1	355	41173	8.38	7	Cell membrane	NA	Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.	NA	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines;Interleukin-10 signaling	PE1	3
+NX_P32247	Bombesin receptor subtype-3	399	44411	8.99	7	Cell membrane	NA	Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	X
+NX_P32248	C-C chemokine receptor type 7	378	42874	8.82	7	Mitochondrion;Cell membrane	NA	Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.	NA	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	17
+NX_P32249	G-protein coupled receptor 183	361	41224	9.31	7	Cytoplasmic vesicle;Nucleus membrane;Cell membrane	NA	G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Class A/1 (Rhodopsin-like receptors)	PE1	13
+NX_P32297	Neuronal acetylcholine receptor subunit alpha-3	505	57480	6.05	4	Cell membrane;Postsynaptic cell membrane	NA	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily.	Neuroactive ligand-receptor interaction;Cholinergic synapse;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly sodium permeable acetylcholine nicotinic receptors;Highly calcium permeable nicotinic acetylcholine receptors	PE1	15
+NX_P32298	G protein-coupled receptor kinase 4	578	66583	7.93	0	Cytoplasmic vesicle;Cytoplasm;Cell cortex	NA	Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.	Palmitoylated.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Chemokine signaling pathway;Endocytosis;Inactivation, recovery and regulation of the phototransduction cascade	PE1	4
+NX_P32302	C-X-C chemokine receptor type 5	372	41955	8.52	7	Cell membrane	NA	Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.	NA	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	11
+NX_P32314	Forkhead box protein N2	431	47161	5.98	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Binds to the purine-rich region in HTLV-I LTR.	NA	NA	NA	PE1	2
+NX_P32320	Cytidine deaminase	146	16185	6.55	0	Nucleoplasm	NA	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine salvage;Neutrophil degranulation	PE1	1
+NX_P32321	Deoxycytidylate deaminase	178	20016	7.5	0	Nucleoplasm;Cytosol	NA	Supplies the nucleotide substrate for thymidylate synthetase.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	Pyrimidine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	4
+NX_P32322	Pyrroline-5-carboxylate reductase 1, mitochondrial	319	33361	7.18	0	Mitochondrion	Cutis laxa, autosomal recessive, 2B;Cutis laxa, autosomal recessive, 3B	Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.	NA	Belongs to the pyrroline-5-carboxylate reductase family.	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.;Arginine and proline metabolism;Metabolic pathways;Glutamate and glutamine metabolism	PE1	17
+NX_P32418	Sodium/calcium exchanger 1	973	108547	4.91	10	Nucleoplasm;Cell membrane	NA	Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.	NA	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.	Calcium signaling pathway;Cardiac muscle contraction;Endocrine and other factor-regulated calcium reabsorption;Protein digestion and absorption;Mineral absorption;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis	PE1	2
+NX_P32455	Guanylate-binding protein 1	592	67931	5.97	0	Golgi apparatus membrane;Cytoplasm;Secreted;Cell membrane	NA	Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.	Isoprenylation is required for proper subcellular location.	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	Interferon gamma signaling	PE1	1
+NX_P32456	Guanylate-binding protein 2	591	67209	5.54	0	Cytoplasm;Membrane;Nucleoplasm;Golgi apparatus membrane;Cytosol;Perinuclear region;Cytoskeleton	NA	Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	Isoprenylation is required for proper subcellular location.	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	Interferon gamma signaling;Interferon alpha/beta signaling	PE1	1
+NX_P32519	ETS-related transcription factor Elf-1	619	67498	5.09	0	Nucleoplasm;Nucleus	NA	Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.	NA	Belongs to the ETS family.	RUNX1 regulates transcription of genes involved in BCR signaling;RUNX1 regulates transcription of genes involved in interleukin signaling	PE1	13
+NX_P32745	Somatostatin receptor type 3	418	45847	8.91	7	Cell membrane	NA	Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.	Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors;BBSome-mediated cargo-targeting to cilium	PE1	22
+NX_P32754	4-hydroxyphenylpyruvate dioxygenase	393	44934	6.52	0	Nucleus speckle	Tyrosinemia 3;Hawkinsinuria	Key enzyme in the degradation of tyrosine.	NA	Belongs to the 4HPPD family.	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.;Ubiquinone and other terpenoid-quinone biosynthesis;Tyrosine metabolism;Phenylalanine metabolism;Metabolic pathways;Tyrosine catabolism	PE1	12
+NX_P32780	General transcription factor IIH subunit 1	548	62032	8.8	0	Nucleoplasm;Nucleus	NA	Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.	NA	Belongs to the TFB1 family.	Basal transcription factors;Nucleotide excision repair;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Tat-mediated elongation of the HIV-1 transcript;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;TP53 Regulates Transcription of DNA Repair Genes	PE1	11
+NX_P32856	Syntaxin-2	288	33341	5.92	1	Membrane;Nucleoplasm;Cytosol	NA	Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.	NA	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;Synaptic vesicle cycle	PE1	12
+NX_P32881	Interferon alpha-8	189	21989	5.32	0	Secreted	NA	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;Regulation of autophagy;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Autoimmune thyroid disease;Factors involved in megakaryocyte development and platelet production;Interferon alpha/beta signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation	PE1	9
+NX_P32926	Desmoglein-3	999	107533	4.86	1	Desmosome;Cell membrane	NA	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	NA	NA	Apoptotic cleavage of cell adhesion proteins;Formation of the cornified envelope;Keratinization	PE1	18
+NX_P32927	Cytokine receptor common subunit beta	897	97336	5.33	1	Membrane;Golgi apparatus	Pulmonary surfactant metabolism dysfunction 5	High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.	May be phosphorylated by LYN.;CSF2RB is phosphorylated by PIK3CB	Belongs to the type I cytokine receptor family. Type 4 subfamily.	Cytokine-cytokine receptor interaction;Apoptosis;Jak-STAT signaling pathway;RAF/MAP kinase cascade;Interleukin receptor SHC signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling;Surfactant metabolism;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	PE1	22
+NX_P32929	Cystathionine gamma-lyase	405	44508	6.21	0	Cytoplasm	Cystathioninuria	Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.	NA	Belongs to the trans-sulfuration enzymes family.	Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.;Glycine, serine and threonine metabolism;Cysteine and methionine metabolism;Selenocompound metabolism;Nitrogen metabolism;Metabolic pathways;Degradation of cysteine and homocysteine;Cysteine formation from homocysteine;Metabolism of ingested SeMet, Sec, MeSec into H2Se	PE1	1
+NX_P32942	Intercellular adhesion molecule 3	547	59541	5.31	1	Membrane;Nucleoplasm;Mitochondrion;Nucleus membrane	NA	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).	Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.;N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.	Belongs to the immunoglobulin superfamily. ICAM family.	Cell adhesion molecules (CAMs);Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions;CD209 (DC-SIGN) signaling	PE1	19
+NX_P32969	60S ribosomal protein L9	192	21863	9.96	0	Endoplasmic reticulum;Cytoplasm;Cytosol;Nucleolus	NA	NA	NA	Belongs to the universal ribosomal protein uL6 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	X
+NX_P32970	CD70 antigen	193	21118	8.93	1	Membrane;Nucleoplasm	Lymphoproliferative syndrome 3	Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.	NA	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	19
+NX_P32971	Tumor necrosis factor ligand superfamily member 8	234	26017	7.62	1	Membrane	NA	Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.	NA	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	9
+NX_P33032	Melanocortin receptor 5	325	36601	8.75	7	Cell membrane	NA	Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (s) signalling events	PE1	18
+NX_P33076	MHC class II transactivator	1130	123514	5.3	0	Nucleoplasm;Nucleus;PML body	Bare lymphocyte syndrome 2	Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).	Autophosphorylated, affecting interaction with TAF7.	NA	Antigen processing and presentation;Toxoplasmosis;Tuberculosis;Influenza A;Primary immunodeficiency;Interferon gamma signaling	PE1	16
+NX_P33121	Long-chain-fatty-acid--CoA ligase 1	698	77943	6.81	1	Microsome membrane;Mitochondrion outer membrane;Endoplasmic reticulum membrane;Mitochondrion;Peroxisome membrane;Nucleoplasm	NA	Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Fatty acid metabolism;Metabolic pathways;PPAR signaling pathway;Peroxisome;Adipocytokine signaling pathway;PPARA activates gene expression;Synthesis of very long-chain fatty acyl-CoAs;Linoleic acid (LA) metabolism;alpha-linolenic acid (ALA) metabolism	PE1	4
+NX_P33151	Cadherin-5	784	87528	5.22	1	Nucleoplasm;Cell junction;Nucleus membrane;Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120).	Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).;O-glycosylated.	NA	Cell adhesion molecules (CAMs);Leukocyte transendothelial migration;VEGFR2 mediated vascular permeability;Adherens junctions interactions	PE1	16
+NX_P33176	Kinesin-1 heavy chain	963	109685	6.12	0	Cytosol;Centriolar satellite;Cytoskeleton	NA	Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.	Dopaminergic synapse;MHC class II antigen presentation;Insulin processing;Kinesins;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic	PE1	10
+NX_P33240	Cleavage stimulation factor subunit 2	577	60959	6.36	0	Nucleoplasm;Nucleus	NA	One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).	NA	NA	mRNA surveillance pathway;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;tRNA processing in the nucleus;RNA Polymerase II Transcription Termination	PE1	X
+NX_P33241	Lymphocyte-specific protein 1	339	37192	4.69	0	Cell membrane	NA	May play a role in mediating neutrophil activation and chemotaxis.	Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis (By similarity).	NA	Tuberculosis	PE1	11
+NX_P33260	Cytochrome P450 2C18	490	55711	6.83	0	Microsome membrane;Endoplasmic reticulum membrane	NA	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	NA	Belongs to the cytochrome P450 family.	Arachidonic acid metabolism;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Xenobiotics	PE1	10
+NX_P33261	Cytochrome P450 2C19	490	55931	7.11	0	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307).	NA	Belongs to the cytochrome P450 family.	Terpene metabolism; (4R)-limonene degradation.;Lipid metabolism; fatty acid metabolism.;Arachidonic acid metabolism;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Xenobiotics;Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET);CYP2E1 reactions;Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	PE1	10
+NX_P33316	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial	252	26563	9.46	0	Nucleoplasm;Mitochondrion;Nucleus	NA	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Is not phosphorylated.;Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner.	Belongs to the dUTPase family.	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.;Pyrimidine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	15
+NX_P33402	Guanylate cyclase soluble subunit alpha-2	732	81750	7.77	0	Cytoplasm	NA	Has guanylyl cyclase on binding to the beta-1 subunit.;Acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.	NA	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Vascular smooth muscle contraction;Gap junction;Long-term depression;Salivary secretion;Smooth Muscle Contraction;Nitric oxide stimulates guanylate cyclase	PE1	11
+NX_P33527	Multidrug resistance-associated protein 1	1531	171591	6.71	17	Cell membrane	NA	Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).	NA	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.	ABC transporters;Vitamin digestion and absorption;Cobalamin (Cbl, vitamin B12) transport and metabolism;ABC-family proteins mediated transport;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	16
+NX_P33552	Cyclin-dependent kinases regulatory subunit 2	79	9860	8.07	0	Cytoplasm	NA	Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	NA	Belongs to the CKS family.	NA	PE1	9
+NX_P33681	T-lymphocyte activation antigen CD80	288	33048	7.58	1	Membrane	NA	(Microbial infection) Acts as a receptor for adenovirus subgroup B.;Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.	NA	NA	Cell adhesion molecules (CAMs);Toll-like receptor signaling pathway;Intestinal immune network for IgA production;Type I diabetes mellitus;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;CD28 dependent PI3K/Akt signaling;CD28 co-stimulation;CD28 dependent Vav1 pathway;CTLA4 inhibitory signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-10 signaling	PE1	3
+NX_P33763	Protein S100-A5	92	10744	5.01	0	Nucleoplasm	NA	Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.	NA	Belongs to the S-100 family.	NA	PE1	1
+NX_P33764	Protein S100-A3	101	11713	4.71	0	Golgi apparatus;Cytosol;Cytoplasm;Cell membrane	NA	Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.	More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization.	Belongs to the S-100 family.	NA	PE1	1
+NX_P33778	Histone H2B type 1-B	126	13950	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.;Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_P33897	ATP-binding cassette sub-family D member 1	745	82937	9.09	5	Mitochondrion membrane;Peroxisome membrane;Lysosome membrane;Endoplasmic reticulum membrane	Adrenoleukodystrophy	Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (PubMed:15682271, PubMed:11248239, PubMed:16946495). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:23671276). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial function like, mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity).	Tyrosine-phosphorylated.	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.	ABC transporters;Peroxisome;ABC transporters in lipid homeostasis;Linoleic acid (LA) metabolism;alpha-linolenic acid (ALA) metabolism;Beta-oxidation of very long chain fatty acids;Defective ABCD1 causes adrenoleukodystrophy (ALD);Class I peroxisomal membrane protein import	PE1	X
+NX_P33908	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA	653	72969	6.04	1	Golgi apparatus;Golgi apparatus membrane	NA	Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).	NA	Belongs to the glycosyl hydrolase 47 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2;Intra-Golgi traffic	PE1	6
+NX_P33947	ER lumen protein-retaining receptor 2	212	24422	8.86	7	COPI-coated vesicle membrane;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (PubMed:1325562, PubMed:18086916). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).	NA	Belongs to the ERD2 family.	Vibrio cholerae infection;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	7
+NX_P33981	Dual specificity protein kinase TTK	857	97072	8.41	0	Cytosol;Nucleolus	NA	Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	Cell cycle	PE1	6
+NX_P33991	DNA replication licensing factor MCM4	863	96558	6.28	0	Nucleoplasm;Nucleus	Immunodeficiency 54	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.	Sumoylated; SUMO2 modified in response to stress caused by inhibition of proteasome activity (in vitro).	Belongs to the MCM family.	DNA replication;Cell cycle;Orc1 removal from chromatin;Activation of ATR in response to replication stress;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;Unwinding of DNA;Switching of origins to a post-replicative state	PE1	8
+NX_P33992	DNA replication licensing factor MCM5	734	82286	8.64	0	Nucleoplasm;Cytosol;Nucleus	Meier-Gorlin syndrome 8	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.	NA	Belongs to the MCM family.	DNA replication;Cell cycle;Orc1 removal from chromatin;Activation of ATR in response to replication stress;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;Unwinding of DNA;Switching of origins to a post-replicative state	PE1	22
+NX_P33993	DNA replication licensing factor MCM7	719	81308	6.08	0	Nucleoplasm;Nucleus	NA	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.	O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.	Belongs to the MCM family.	DNA replication;Cell cycle;Orc1 removal from chromatin;Activation of ATR in response to replication stress;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;Unwinding of DNA;Switching of origins to a post-replicative state	PE1	7
+NX_P34059	N-acetylgalactosamine-6-sulfatase	522	58026	6.25	0	Cytosol;Lysosome	Mucopolysaccharidosis 4A	NA	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Glycosaminoglycan degradation;Metabolic pathways;Lysosome;Keratan sulfate degradation;MPS IV - Morquio syndrome A;Neutrophil degranulation	PE1	16
+NX_P34096	Ribonuclease 4	147	16840	9.3	0	Secreted	NA	This RNase has marked specificity towards the 3' side of uridine nucleotides.	NA	Belongs to the pancreatic ribonuclease family.	NA	PE1	14
+NX_P34130	Neurotrophin-4	210	22427	9.01	0	Golgi apparatus;Secreted	Glaucoma 1, open angle, O	Target-derived survival factor for peripheral sensory sympathetic neurons.	NA	Belongs to the NGF-beta family.	MAPK signaling pathway;Neurotrophin signaling pathway;Activated NTRK2 signals through RAS;Activated NTRK2 signals through FRS2 and FRS3;NTF4 activates NTRK2 (TRKB) signaling;Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through PI3K	PE1	19
+NX_P34741	Syndecan-2	201	22160	4.75	1	Membrane;Cytosol;Cell membrane	NA	Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).	O-glycosylated with core 1 or possibly core 8 glycans. Contains heparan sulfate.	Belongs to the syndecan proteoglycan family.	ECM-receptor interaction;Cell adhesion molecules (CAMs);Malaria;Retinoid metabolism and transport;EPHB-mediated forward signaling;HS-GAG biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Syndecan interactions;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Cell surface interactions at the vascular wall;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Defective B3GALT6 causes EDSP2 and SEMDJL1;Post-translational protein phosphorylation	PE1	8
+NX_P34810	Macrosialin	354	37408	9.1	1	Golgi apparatus;Endosome membrane;Cell membrane;Lysosome membrane;Cytoplasmic vesicle	NA	Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.	N- and O-glycosylated.	Belongs to the LAMP family.	Lysosome;Neutrophil degranulation	PE1	17
+NX_P34820	Bone morphogenetic protein 8B	402	44768	8.76	0	Secreted	NA	Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).	NA	Belongs to the TGF-beta family.	Hedgehog signaling pathway;TGF-beta signaling pathway	PE1	1
+NX_P34896	Serine hydroxymethyltransferase, cytosolic	483	53083	7.61	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).	NA	Belongs to the SHMT family.	One-carbon metabolism; tetrahydrofolate interconversion.;Glycine, serine and threonine metabolism;Cyanoamino acid metabolism;One carbon pool by folate;Metabolic pathways;Metabolism of folate and pterines;Carnitine synthesis	PE1	17
+NX_P34897	Serine hydroxymethyltransferase, mitochondrial	504	55993	8.76	0	Cytoplasm;Mitochondrion;Mitochondrion nucleoid;Mitochondrion inner membrane;Nucleus;Cytoskeleton	NA	Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:29364879, PubMed:25619277). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29452640, PubMed:29364879). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985).	Succinylation at Lys-280 inhibits the hydroxymethyltransferase activity. Desuccinylation by SIRT5 restores the activity, leading to promote cell proliferation.	Belongs to the SHMT family.	One-carbon metabolism; tetrahydrofolate interconversion.;Glycine, serine and threonine metabolism;Cyanoamino acid metabolism;One carbon pool by folate;Metabolic pathways;Metabolism of folate and pterines	PE1	12
+NX_P34903	Gamma-aminobutyric acid receptor subunit alpha-3	492	55165	8.81	4	Cell membrane;Postsynaptic cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;GABA receptor activation	PE1	X
+NX_P34910	Protein EVI2B	448	48666	4.67	1	Membrane	NA	Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells.	NA	NA	NA	PE1	17
+NX_P34913	Bifunctional epoxide hydrolase 2	555	62616	5.91	0	Peroxisome;Cytosol;Cytoplasm	NA	Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510).	The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (Probable).;The N-terminus is blocked.	Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.	Arachidonic acid metabolism;Metabolic pathways;Peroxisome;Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET);Peroxisomal protein import;Biosynthesis of maresins	PE1	8
+NX_P34925	Tyrosine-protein kinase RYK	607	67815	6.92	1	Golgi apparatus;Cytoplasm;Membrane;Cytosol;Nucleus	NA	May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.	Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation.	Belongs to the protein kinase superfamily. Tyr protein kinase family.	TCF dependent signaling in response to WNT;PCP/CE pathway	PE1	3
+NX_P34931	Heat shock 70 kDa protein 1-like	641	70375	5.76	0	NA	NA	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).	NA	Belongs to the heat shock protein 70 family.	Spliceosome;MAPK signaling pathway;Protein processing in endoplasmic reticulum;Endocytosis;Antigen processing and presentation;Legionellosis;Toxoplasmosis;Measles;Influenza A;Regulation of HSF1-mediated heat shock response;Attenuation phase;HSF1-dependent transactivation;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	6
+NX_P34932	Heat shock 70 kDa protein 4	840	94331	5.11	0	Nucleoplasm;Cytosol;Cytoplasm	NA	NA	NA	Belongs to the heat shock protein 70 family.	Antigen processing and presentation;Regulation of HSF1-mediated heat shock response	PE1	5
+NX_P34947	G protein-coupled receptor kinase 5	590	67787	8.39	0	Cytoplasm;Nucleus speckle;Cell membrane;Nucleus membrane;Nucleus	NA	Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).	Autophosphorylated. Autophosphorylation may play a critical role in the regulation of GRK5 kinase activity.;GRK5 is phosphorylated by PRKCA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Chemokine signaling pathway;Endocytosis;G alpha (q) signalling events;G alpha (s) signalling events	PE1	10
+NX_P34949	Mannose-6-phosphate isomerase	423	46656	5.62	0	Cytoplasm;Cytosol;Cell membrane	Congenital disorder of glycosylation 1B	Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.	NA	Belongs to the mannose-6-phosphate isomerase type 1 family.	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.;Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Defective MPI causes MPI-CDG (CDG-1b);Synthesis of GDP-mannose	PE1	15
+NX_P34969	5-hydroxytryptamine receptor 7	479	53555	9.09	7	Cytosol;Nucleus speckle;Cell membrane	NA	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Serotonin receptors	PE1	10
+NX_P34972	Cannabinoid receptor 2	360	39681	8.52	7	Perikaryon;Dendrite;Cell membrane	NA	Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.	Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Class A/1 (Rhodopsin-like receptors)	PE1	1
+NX_P34981	Thyrotropin-releasing hormone receptor	398	45085	8.62	7	Cell membrane	NA	Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	8
+NX_P34982	Olfactory receptor 1D2	312	35240	9.07	7	Cell membrane	NA	Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE1	17
+NX_P34995	Prostaglandin E2 receptor EP1 subtype	402	41801	11.72	7	Cell membrane	NA	Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.	Phosphorylated.	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Prostanoid ligand receptors	PE2	19
+NX_P34998	Corticotropin-releasing factor receptor 1	444	50719	9.47	7	Endosome;Cell membrane	NA	G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.	C-terminal Ser or Thr residues may be phosphorylated.;Phosphorylation at Ser-330 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling.	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;Long-term depression;G alpha (s) signalling events;Class B/2 (Secretin family receptors)	PE1	17
+NX_P35030	Trypsin-3	304	32529	7.46	0	Secreted	NA	Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors.	NA	Belongs to the peptidase S1 family.	Neuroactive ligand-receptor interaction;Pancreatic secretion;Protein digestion and absorption;Influenza A;Alpha-defensins;Cobalamin (Cbl, vitamin B12) transport and metabolism;Neutrophil degranulation;Antimicrobial peptides	PE1	9
+NX_P35052	Glypican-1	558	61680	7.07	0	Cytosol;Extracellular space;Endosome;Cell membrane	NA	Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.	N- and O-glycosylated. N-glycosylation is mainly of the complex type containing sialic acid. O-glycosylated with heparan sulfate. The heparan sulfate chains can be cleaved either by the action of heparanase or, degraded by a deaminative process that uses nitric oxide (NO) released from the S-nitrosylated cysteines. This process is triggered by ascorbate, or by some other reducing agent, in a Cu(2+)- or Zn(2+) dependent manner. Cu(2+) ions are provided by ceruloproteins such as APP, PRNP or CP which associate with GCP1 in intracellular compartments or lipid rafts.;This cell-associated glypican is further processed to give rise to a medium-released species.;S-nitrosylated in a Cu(2+)-dependent manner. Nitric acid (NO) is released from the nitrosylated cysteines by ascorbate or by some other reducing agent, in a Cu(2+) or Zn(2+) dependent manner. This free nitric oxide is then capable of cleaving the heparan sulfate side chains.	Belongs to the glypican family.	Retinoid metabolism and transport;HS-GAG biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Cell surface interactions at the vascular wall;Signaling by ROBO receptors;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	2
+NX_P35070	Probetacellulin	178	19746	8.53	1	Cell membrane;Extracellular space	NA	Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.	NA	NA	ErbB signaling pathway;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;EGFR downregulation;Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;PI3K events in ERBB4 signaling;SHC1 events in ERBB4 signaling;Nuclear signaling by ERBB4;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Signaling by EGFR;GAB1 signalosome;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;EGFR interacts with phospholipase C-gamma;Inhibition of Signaling by Overexpressed EGFR;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Extra-nuclear estrogen signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	4
+NX_P35080	Profilin-2	140	15046	6.55	0	Cytoskeleton	NA	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.	NA	Belongs to the profilin family.	Regulation of actin cytoskeleton;Shigellosis;Salmonella infection;RHO GTPases Activate Formins;Signaling by ROBO receptors	PE1	3
+NX_P35125	Ubiquitin carboxyl-terminal hydrolase 6	1406	158658	7.87	0	Cytoplasm;Endosome;Cell membrane	NA	Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.	Monubiquitinated; ubiquitination is calmodulin and calcium dependent.	Belongs to the peptidase C19 family.	NA	PE1	17
+NX_P35212	Gap junction alpha-4 protein	333	37414	7.5	4	Gap junction;Cell membrane	NA	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Alpha-type (group II) subfamily.	Gap junction assembly	PE1	1
+NX_P35218	Carbonic anhydrase 5A, mitochondrial	305	34750	7.18	0	Mitochondrion	Hyperammonemia due to carbonic anhydrase VA deficiency	Reversible hydration of carbon dioxide. Low activity.	NA	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Reversible hydration of carbon dioxide	PE1	16
+NX_P35219	Carbonic anhydrase-related protein	290	32973	4.78	0	NA	Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3	Does not have a carbonic anhydrase catalytic activity.	NA	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism	PE1	8
+NX_P35221	Catenin alpha-1	906	100071	5.95	0	Adherens junction;Cell junction;Cytoskeleton;Cell membrane	Macular dystrophy, patterned, 2	Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.	Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion.;Sumoylated.	Belongs to the vinculin/alpha-catenin family.	Adherens junction;Tight junction;Leukocyte transendothelial migration;Bacterial invasion of epithelial cells;Pathways in cancer;Endometrial cancer;Arrhythmogenic right ventricular cardiomyopathy (ARVC);VEGFR2 mediated vascular permeability;Adherens junctions interactions;RHO GTPases activate IQGAPs;Myogenesis	PE1	5
+NX_P35222	Catenin beta-1	781	85497	5.53	0	Cytoplasm;Cell membrane;Cell junction;Adherens junction;Cilium basal body;Spindle pole;Centrosome;Synapse;Nucleus;Cytoskeleton	Medulloblastoma;Neurodevelopmental disorder with spastic diplegia and visual defects;Ovarian cancer;Mesothelioma, malignant;Colorectal cancer;Pilomatrixoma;Vitreoretinopathy, exudative 7	Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).	Deacetylated at Lys-49 by SIRT1.;O-glycosylation at Ser-23 decreases nuclear localization and transcriptional activity, and increases localization to the plasma membrane and interaction with E-cadherin CDH1.;Ubiquitinated by the SCF(BTRC) E3 ligase complex when phosphorylated by GSK3B, leading to its degradation. Ubiquitinated by a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X, leading to its subsequent proteasomal degradation (By similarity).;Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription (By similarity). Phosphorylation by GSK3B requires prior phosphorylation of Ser-45 by another kinase. Phosphorylation proceeds then from Thr-41 to Ser-37 and Ser-33. Phosphorylated by NEK2. EGF stimulates tyrosine phosphorylation. Phosphorylation on Tyr-654 decreases CDH1 binding and enhances TBP binding. Phosphorylated on Ser-33 and Ser-37 by HIPK2 and GSK3B, this phosphorylation triggers proteasomal degradation (PubMed:25169422). Phosphorylation on Ser-191 and Ser-246 by CDK5. Phosphorylation by CDK2 regulates insulin internalization. Phosphorylation by PTK6 at Tyr-64, Tyr-142, Tyr-331 and/or Tyr-333 with the predominant site at Tyr-64 is not essential for inhibition of transcriptional activity.;S-nitrosylation at Cys-619 within adherens junctions promotes VEGF-induced, NO-dependent endothelial cell permeability by disrupting interaction with E-cadherin, thus mediating disassembly adherens junctions.;CTNNB1 is phosphorylated by CHUK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);CTNNB1 is phosphorylated by NEK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);CTNNB1 is phosphorylated by IKBKB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the beta-catenin family.	Wnt signaling pathway;Focal adhesion;Adherens junction;Tight junction;Leukocyte transendothelial migration;Melanogenesis;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;HTLV-I infection;Pathways in cancer;Colorectal cancer;Endometrial cancer;Prostate cancer;Thyroid cancer;Basal cell carcinoma;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Degradation of beta-catenin by the destruction complex;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);VEGFR2 mediated vascular permeability;Formation of the beta-catenin:TCF transactivating complex;TCF dependent signaling in response to WNT;Ca2+ pathway;Apoptotic cleavage of cell adhesion proteins;Deactivation of the beta-catenin transactivating complex;Binding of TCF/LEF:CTNNB1 to target gene promoters;Adherens junctions interactions;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;RHO GTPases activate IQGAPs;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX3 regulates WNT signaling;Myogenesis	PE1	3
+NX_P35225	Interleukin-13	146	15816	8.69	0	Cytosol;Secreted;Cell membrane	Allergic rhinitis	Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).	NA	Belongs to the IL-4/IL-13 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Fc epsilon RI signaling pathway;Measles;Asthma;Interleukin-4 and Interleukin-13 signaling;Interleukin-18 signaling	PE1	5
+NX_P35226	Polycomb complex protein BMI-1	326	36949	8.9	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).	Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.;BMI1 is phosphorylated by MAPKAPK3	NA	SUMOylation of DNA damage response and repair proteins;Oxidative Stress Induced Senescence;SUMOylation of RNA binding proteins;SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins	PE1	10
+NX_P35227	Polycomb group RING finger protein 2	344	37788	8.21	0	Nucleoplasm;Nucleus	Turnpenny-Fry syndrome	Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).	Phosphorylated. Homodimer formation is regulated by phosphorylation with only unphosphorylated proteins forming homodimers.	NA	SUMOylation of DNA damage response and repair proteins;SUMOylation of RNA binding proteins;Activation of anterior HOX genes in hindbrain development during early embryogenesis;SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins	PE1	17
+NX_P35228	Nitric oxide synthase, inducible	1153	131117	8.2	0	Cytosol	NA	Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).	Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.	Belongs to the NOS family.	Arginine and proline metabolism;Metabolic pathways;Calcium signaling pathway;Peroxisome;Salmonella infection;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Tuberculosis;Pathways in cancer;Small cell lung cancer;ROS and RNS production in phagocytes;Nitric oxide stimulates guanylate cyclase;Interleukin-4 and Interleukin-13 signaling;Peroxisomal protein import	PE1	17
+NX_P35232	Prohibitin	272	29804	5.57	0	Cytoplasmic vesicle;Mitochondrion inner membrane;Mitochondrion;Nucleus	NA	Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.	NA	Belongs to the prohibitin family.	RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Processing of SMDT1	PE1	17
+NX_P35236	Tyrosine-protein phosphatase non-receptor type 7	360	40529	6.33	0	Cytoplasm;Cytoskeleton	NA	Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.	Oxidized at active site cysteine. Treatment with pervanadate (vanadate and H(2)O(2)) or with antigen enhanced oxidation of active site cysteine (By similarity).;Phosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases.	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.	MAPK signaling pathway;Interleukin-37 signaling	PE1	1
+NX_P35237	Serpin B6	376	42622	5.18	0	Cytoplasm;Centrosome	Deafness, autosomal recessive, 91	May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.	NA	Belongs to the serpin family. Ov-serpin subfamily.	Amoebiasis;Dissolution of Fibrin Clot;Neutrophil degranulation	PE1	6
+NX_P35240	Merlin	595	69690	6.11	0	Filopodium membrane;Cell membrane;Cytoplasmic granule;Nucleoplasm;Ruffle membrane;Cytosol;Perinuclear region;Nucleus;Cytoskeleton	Mesothelioma, malignant;Neurofibromatosis 2;Schwannomatosis 1	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.	Ubiquitinated by the CUL4A-RBX1-DDB1-DCAF1/VprBP E3 ubiquitin-protein ligase complex for ubiquitination and subsequent proteasome-dependent degradation.;Phosphorylation of Ser-518 inhibits nuclear localization by disrupting the intramolecular association of the FERM domain with the C-terminal tail (PubMed:20178741). The dephosphorylation of Ser-518 favors the interaction with NOP53 (PubMed:21167305).	NA	Regulation of actin dynamics for phagocytic cup formation;RHO GTPases activate PAKs	PE1	22
+NX_P35241	Radixin	583	68564	6.03	0	Cytoplasm;Cleavage furrow;Cell membrane;Nucleoplasm;Microvillus;Cytoskeleton	Deafness, autosomal recessive, 24	Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.	Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).	NA	Regulation of actin cytoskeleton;Recycling pathway of L1	PE1	11
+NX_P35243	Recoverin	200	23130	5.06	0	Photoreceptor inner segment;Photoreceptor outer segment;Perikaryon;Photoreceptor outer segment membrane	NA	Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity).	Oxidation on Cys-39 occurs in response to prolonged intense illumination and results in the formation of disulfide homodimers, and to a lesser extent disulfide-linked heterodimers.;The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present (By similarity). The Ca(2+) induced exposure of the myristoyl group, known as the calcium-myristoyl switch, promotes RCVRN binding to the photoreceptor cell membranes only when intracellular Ca(2+) concentration is high (By similarity).	Belongs to the recoverin family.	Phototransduction;Inactivation, recovery and regulation of the phototransduction cascade	PE1	17
+NX_P35244	Replication protein A 14 kDa subunit	121	13569	4.96	0	Nucleus	NA	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).	Ubiquitinated by RFWD3 at stalled replication forks in response to DNA damage: ubiquitination by RFWD3 does not lead to degradation by the proteasome and promotes removal of the RPA complex from stalled replication forks, promoting homologous recombination (PubMed:26474068).	NA	DNA replication;Nucleotide excision repair;Mismatch repair;Homologous recombination;Fanconi anemia pathway;Regulation of HSF1-mediated heat shock response;Translesion Synthesis by POLH;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Meiotic recombination;Activation of ATR in response to replication stress;Activation of the pre-replicative complex;G2/M DNA damage checkpoint;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Removal of the Flap Intermediate from the C-strand;Removal of the Flap Intermediate;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation	PE1	7
+NX_P35247	Pulmonary surfactant-associated protein D	375	37728	6.25	0	Surface film;Extracellular matrix	NA	Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.	The N-terminus is blocked.;Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.;S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.	Belongs to the SFTPD family.	Phagosome;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Toll Like Receptor 4 (TLR4) Cascade;Toll Like Receptor TLR1:TLR2 Cascade;Signal regulatory protein family interactions;Surfactant metabolism;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4);Regulation of TLR by endogenous ligand	PE1	10
+NX_P35249	Replication factor C subunit 4	363	39682	8.26	0	Nucleoplasm;Nucleus	NA	The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.	NA	Belongs to the activator 1 small subunits family.	DNA replication;Nucleotide excision repair;Mismatch repair;Translesion Synthesis by POLH;Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Polymerase switching on the C-strand of the telomere;Polymerase switching;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Regulation of TP53 Activity through Phosphorylation	PE1	3
+NX_P35250	Replication factor C subunit 2	354	39157	6.04	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).	NA	Belongs to the activator 1 small subunits family.	DNA replication;Nucleotide excision repair;Mismatch repair;Translesion Synthesis by POLH;Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Polymerase switching on the C-strand of the telomere;Polymerase switching;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Regulation of TP53 Activity through Phosphorylation	PE1	7
+NX_P35251	Replication factor C subunit 1	1148	128255	9.38	0	Nucleoplasm;Nucleolus;Nucleus	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.;Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.	NA	Belongs to the activator 1 large subunit family.	DNA replication;Nucleotide excision repair;Mismatch repair;Translesion Synthesis by POLH;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Polymerase switching on the C-strand of the telomere;Polymerase switching;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER	PE1	4
+NX_P35268	60S ribosomal protein L22	128	14787	9.21	0	Cytoplasm;Nucleolus	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL22 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	1
+NX_P35269	General transcription factor IIF subunit 1	517	58240	7.04	0	Nucleoplasm;Cell junction;Nucleus	NA	TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.	Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases.	Belongs to the TFIIF alpha subunit family.	Basal transcription factors;Viral Messenger RNA Synthesis;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	19
+NX_P35270	Sepiapterin reductase	261	28048	8.25	0	Nucleoplasm;Cytoplasm;Cytosol	Dystonia, DOPA-responsive, due to sepiapterin reductase deficiency	Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.	In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.	Belongs to the sepiapterin reductase family.	Folate biosynthesis;Metabolic pathways;eNOS activation;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	PE1	2
+NX_P35318	ADM	185	20420	10.84	0	Secreted	NA	AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.	NA	Belongs to the adrenomedullin family.	G alpha (s) signalling events;Calcitonin-like ligand receptors	PE1	11
+NX_P35321	Cornifin-A	89	9877	8.85	0	Cytoplasm	NA	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.	NA	Belongs to the cornifin (SPRR) family.	Formation of the cornified envelope	PE1	1
+NX_P35325	Small proline-rich protein 2B	72	7975	8.81	0	Cytoplasm	NA	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.	NA	Belongs to the cornifin (SPRR) family.	Formation of the cornified envelope	PE2	1
+NX_P35326	Small proline-rich protein 2A	72	7965	8.81	0	Cytoplasm	NA	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.	NA	Belongs to the cornifin (SPRR) family.	Formation of the cornified envelope	PE1	1
+NX_P35346	Somatostatin receptor type 5	364	39202	9.58	7	Cell membrane	NA	Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.	Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	16
+NX_P35348	Alpha-1A adrenergic receptor	466	51487	9.26	7	Cytoplasm;Caveola;Nucleus membrane;Cell membrane	NA	This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.	C-terminal Ser or Thr residues may be phosphorylated.	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;Salivary secretion;G alpha (q) signalling events;G alpha (12/13) signalling events;Adrenoceptors	PE1	8
+NX_P35354	Prostaglandin G/H synthase 2	604	68996	7.02	0	Microsome membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, that regulates phagocytic microglia (By similarity).	S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.;Acetylated at Ser-565 by SPHK1. During neuroinflammation, acetylation by SPHK1 promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.	Belongs to the prostaglandin G/H synthase family.	Lipid metabolism; prostaglandin biosynthesis.;Arachidonic acid metabolism;Metabolic pathways;VEGF signaling pathway;Leishmaniasis;Pathways in cancer;Small cell lung cancer;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Nicotinamide salvaging;Synthesis of 15-eicosatetraenoic acid derivatives;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Biosynthesis of DHA-derived SPMs;Biosynthesis of EPA-derived SPMs;Biosynthesis of DPAn-3 SPMs;Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives	PE1	1
+NX_P35367	Histamine H1 receptor	487	55784	9.33	7	Cytosol;Cell membrane	NA	In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.	Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Histamine receptors	PE1	3
+NX_P35368	Alpha-1B adrenergic receptor	520	56836	9.53	7	Cytoplasm;Caveola;Nucleus membrane;Cell membrane	NA	This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.	NA	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;Salivary secretion;G alpha (q) signalling events;G alpha (12/13) signalling events;Adrenoceptors	PE1	5
+NX_P35372	Mu-type opioid receptor	400	44779	8.62	7	Cytoplasm;Cell membrane;Perikaryon;Endosome;Axon;Dendrite	NA	Do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity (PubMed:16580639).;Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:7905839, PubMed:7957926, PubMed:7891175, PubMed:12589820, PubMed:9689128). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis.;Couples to GNAS and is proposed to be involved in excitatory effects (PubMed:20525224).	Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.;Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by GRK2 in a agonist-dependent manner. Phosphorylation at Tyr-168 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agonist-induced G-protein-independent receptor down-regulation. Phosphorylation at Ser-377 is involved in G-protein-dependent but not beta-arrestin-dependent activation of the ERK pathway (By similarity).	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors;G-protein activation;Opioid Signalling;Interleukin-4 and Interleukin-13 signaling;MECP2 regulates neuronal receptors and channels	PE1	6
+NX_P35398	Nuclear receptor ROR-alpha	523	58975	6.3	0	Nucleus	Intellectual developmental disorder with or without epilepsy or cerebellar ataxia	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development (PubMed:29656859). Regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling.	Phosphorylation by conventional PKCs in neurons inhibits transcriptional activity. Phosphorylated on Thr-183 by MAPK1/ERK1 in vitro.;Monomethylated at Lys-38 by EZH2, this creates a degron recognized by a DCX (DDB1-DCAF1/VPRBP-CUL4A-RBX1) E3 ubiquitin ligase complex.;Sumoylated by SENP1 and SENP2. Sumoylation, promoted by PIAS2, PIAS3, PIAS4 but not PIAS1, enhances the transcriptional activity. Desumoylated by SENP1.;Ubiquitinated, leading to its degradation by the proteasome. Proteasomal degradation is required for efficient transcriptional activity and is prevented by HR.	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Circadian rhythm - mammal;PPARA activates gene expression;RORA activates gene expression;Circadian Clock;Nuclear Receptor transcription pathway;Interleukin-4 and Interleukin-13 signaling;SUMOylation of intracellular receptors	PE1	15
+NX_P35408	Prostaglandin E2 receptor EP4 subtype	488	53119	9.08	7	Cell membrane	NA	Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.	Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Prostanoid ligand receptors	PE1	5
+NX_P35410	Mas-related G-protein coupled receptor MRG	378	42411	8.71	7	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.	NA	PE2	6
+NX_P35414	Apelin receptor	380	42660	7.46	7	Cell membrane	NA	Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. The position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936).;(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:11090199).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	11
+NX_P35442	Thrombospondin-2	1172	129991	4.62	0	Cytosol;Nucleus speckle;Cell membrane	Intervertebral disc disease	Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.	NA	Belongs to the thrombospondin family.	Phagosome;TGF-beta signaling pathway;Focal adhesion;ECM-receptor interaction;Malaria;O-glycosylation of TSR domain-containing proteins;Signaling by PDGF;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	6
+NX_P35443	Thrombospondin-4	961	105869	4.44	0	Extracellular matrix;Secreted;Sarcoplasmic reticulum;Endoplasmic reticulum;Extracellular space;Cytoplasmic vesicle	NA	Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).	NA	Belongs to the thrombospondin family.	Phagosome;TGF-beta signaling pathway;Focal adhesion;ECM-receptor interaction;Malaria;Signaling by PDGF	PE1	5
+NX_P35452	Homeobox protein Hox-D12	270	29031	9.82	0	Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	2
+NX_P35453	Homeobox protein Hox-D13	343	36101	9.5	0	Nucleoplasm;Nucleus	Brachydactyly E1;Brachydactyly D;Syndactyly 5;Brachydactyly-syndactyly syndrome;Brachydactyly-syndactyly-oligodactyly syndrome;VACTERL association;Synpolydactyly 1	Sequence-specific transcription factor that binds gene promoters and activates their transcription (PubMed:24789103). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity).	NA	Belongs to the Abd-B homeobox family.	NA	PE1	2
+NX_P35462	D(3) dopamine receptor	400	44225	9.2	7	Cell membrane	Tremor, hereditary essential 1;Schizophrenia	Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.	Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).;Palmitoylated.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Dopaminergic synapse;G alpha (i) signalling events;Dopamine receptors	PE1	3
+NX_P35475	Alpha-L-iduronidase	653	72670	9.25	0	Cytoplasmic vesicle;Lysosome	Mucopolysaccharidosis 1H/S;Mucopolysaccharidosis 1H;Mucopolysaccharidosis 1S	NA	N-glycosylation at Asn-372 contributes to substrate binding and is required for full enzymatic activity.	Belongs to the glycosyl hydrolase 39 family.	Glycosaminoglycan degradation;Metabolic pathways;Lysosome;HS-GAG degradation;CS/DS degradation;MPS I - Hurler syndrome	PE1	4
+NX_P35498	Sodium channel protein type 1 subunit alpha	2009	228972	5.6	24	Nucleoplasm;Nucleus;Cell membrane	Generalized epilepsy with febrile seizures plus 2;Migraine, familial hemiplegic, 3;Febrile seizures, familial, 3A;Epileptic encephalopathy, early infantile, 6;Intractable childhood epilepsy with generalized tonic-clonic seizures	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli.	Phosphorylation at Ser-1516 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.1/SCN1A subfamily.	Dopaminergic synapse;Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	2
+NX_P35499	Sodium channel protein type 4 subunit alpha	1836	208061	4.99	24	Nucleoplasm;Centriolar satellite;Cell membrane	Periodic paralysis hyperkalemic;Paramyotonia congenita of von Eulenburg;Myotonia SCN4A-related;Periodic paralysis normokalemic;Myasthenic syndrome, congenital, 16;Periodic paralysis hypokalemic 2	Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states (PubMed:12766226, PubMed:29992740, PubMed:30190309, PubMed:15318338, PubMed:16890191, PubMed:18690054, PubMed:17898326, PubMed:19347921, PubMed:25707578, PubMed:26700687). Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels (PubMed:12766226, PubMed:15318338, PubMed:16890191, PubMed:19347921, PubMed:25707578, PubMed:26700687, PubMed:26659129).	Phosphorylation at Ser-1328 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	17
+NX_P35503	UDP-glucuronosyltransferase 1-3	534	60338	8.41	1	Endoplasmic reticulum membrane;Microsome	NA	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.;Lacks transferase activity but acts as a negative regulator of isoform 1.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	2
+NX_P35504	UDP-glucuronosyltransferase 1-5	534	60071	8.24	1	Endoplasmic reticulum membrane;Microsome	NA	Lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).;UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE2	2
+NX_P35520	Cystathionine beta-synthase	551	60587	6.2	0	Cytoplasmic vesicle;Nucleus;Cytoplasm;Nucleolus	Cystathionine beta-synthase deficiency	Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	NA	Belongs to the cysteine synthase/cystathionine beta-synthase family.	Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.;Glycine, serine and threonine metabolism;Cysteine and methionine metabolism;Metabolic pathways;Cysteine formation from homocysteine;Metabolism of ingested SeMet, Sec, MeSec into H2Se	PE1	21
+NX_P35523	Chloride channel protein 1	988	108626	5.68	10	Cell membrane	Myotonia congenita, autosomal dominant;Myotonia congenita, autosomal recessive	Voltage-gated chloride channel (PubMed:8112288, PubMed:9122265, PubMed:12456816). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction.	NA	Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.	Stimuli-sensing channels	PE1	7
+NX_P35527	Keratin, type I cytoskeletal 9	623	62064	5.14	0	NA	Keratoderma, palmoplantar, epidermolytic	May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_P35542	Serum amyloid A-4 protein	130	14747	9.17	0	Secreted	NA	Major acute phase reactant. Apolipoprotein of the HDL complex.	NA	Belongs to the SAA family.	NA	PE1	11
+NX_P35544	Ubiquitin-like protein FUBI	74	7760	4.31	0	NA	NA	NA	NA	Belongs to the ubiquitin family.	Ribosome	PE1	11
+NX_P35548	Homeobox protein MSX-2	267	28897	9.68	0	Nucleus speckle;Nucleus	Craniosynostosis 2;Parietal foramina with cleidocranial dysplasia;Parietal foramina 1	Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.	NA	Belongs to the Msh homeobox family.	HTLV-I infection;Regulation of RUNX2 expression and activity	PE1	5
+NX_P35555	Fibrillin-1	2871	312298	4.81	0	Cytosol;Extracellular matrix;Secreted	Geleophysic dysplasia 2;Overlap connective tissue disease;Marfan syndrome;Acromicric dysplasia;Stiff skin syndrome;Weill-Marchesani syndrome 2;Marfanoid-progeroid-lipodystrophy syndrome;Ectopia lentis 1, isolated, autosomal dominant	Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873, PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921).;Asprosin: Hormone that targets the liver to increase plasma glucose levels. Secreted by white adipose tissue and circulates in the plasma. Acts in response to fasting and promotes blood glucose elevation by binding to the surface of hepatocytes. Promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation.	Fibrillin-1: Cleavage of N- and C-terminus by furin is required for incorporation into the extracellular matrix and assembly into microfibrils (PubMed:27026396). The C-terminus, which corresponds to the Asprosin chain, was initially thought to constitute a propeptide (PubMed:24982166). Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin, an essential step for incorporation of Fibrillin-1 into the nascent microfibrils (PubMed:24982166).;Fibrillin-1: Forms intermolecular disulfide bonds either with other fibrillin-1 molecules or with other components of the microfibrils.	Belongs to the fibrillin family.	Degradation of the extracellular matrix;Integrin cell surface interactions;Molecules associated with elastic fibres;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Elastic fibre formation;Post-translational protein phosphorylation	PE1	15
+NX_P35556	Fibrillin-2	2912	314775	4.73	0	Nucleoplasm;Cytosol;Extracellular matrix	Macular degeneration, early-onset;Contractural arachnodactyly, congenital	Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.	NA	Belongs to the fibrillin family.	Degradation of the extracellular matrix;Molecules associated with elastic fibres;Elastic fibre formation	PE1	5
+NX_P35557	Hexokinase-4	465	52191	5.1	0	Golgi apparatus;Cytoplasm;Mitochondrion;Cytosol;Nucleus	Diabetes mellitus, non-insulin-dependent;Familial hyperinsulinemic hypoglycemia 3;Maturity-onset diabetes of the young 2;Diabetes mellitus, permanent neonatal	Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:7742312, PubMed:11916951, PubMed:15277402, PubMed:17082186, PubMed:18322640, PubMed:19146401, PubMed:25015100, PubMed:8325892). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (PubMed:18322640, PubMed:25015100, PubMed:8325892, PubMed:11916951, PubMed:15277402). Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (By similarity). In pancreas, plays an important role in modulating insulin secretion (By similarity). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (By similarity). Required to provide D-glucose 6-phosphate for the synthesis of glycogen (PubMed:8878425). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:7742312).	NA	Belongs to the hexokinase family.	Carbohydrate metabolism; hexose metabolism.;Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.;Glycolysis / Gluconeogenesis;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Butirosin and neomycin biosynthesis;Metabolic pathways;Insulin signaling pathway;Type II diabetes mellitus;Maturity onset diabetes of the young;Regulation of Glucokinase by Glucokinase Regulatory Protein;Glycolysis;Regulation of gene expression in beta cells;Defective GCK causes maturity-onset diabetes of the young 2 (MODY2);Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	7
+NX_P35558	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	622	69195	5.8	0	Cytoplasm	Phosphoenolpyruvate carboxykinase deficiency, cytosolic	Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate.	Ubiquitination by UBR5 leads to proteasomal degradation.;Acetylated. Lysine acetylation by p300/EP300 is increased on high glucose conditions (PubMed:20167786, PubMed:21726808, PubMed:30193097). Lysine acetylation promotes ubiquitination by UBR5 (PubMed:21726808). Acetylation is enhanced in the presence of BAG6. Deacetylated by SIRT2. Deacetylation of Lys-91 is carried out by SIRT1 and depends on PCK1 phosphorylation levels (PubMed:30193097).;Phosphorylated in a GSK3B-mediated pathway; phosphorylation affects the efficiency of SIRT1-mediated deacetylation, and regulates PCK1 ubiquitination and degradation.	Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.	Carbohydrate biosynthesis; gluconeogenesis.;Glycolysis / Gluconeogenesis;Citrate cycle (TCA cycle);Pyruvate metabolism;Metabolic pathways;PPAR signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Proximal tubule bicarbonate reclamation;Gluconeogenesis;Transcriptional regulation of white adipocyte differentiation;Abacavir metabolism;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	20
+NX_P35568	Insulin receptor substrate 1	1242	131591	8.83	0	Nucleoplasm;Cytosol;Cell membrane	Diabetes mellitus, non-insulin-dependent	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).	Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity). Phosphorylated by ALK. Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1. Phosphorylated on tyrosine residues in response to insulin (By similarity).;Ubiquitinated by the Cul7-RING(FBXW8) complex in a mTOR-dependent manner, leading to its degradation: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2).;IRS1 is phosphorylated by JAK1 (Phosphotyrosine:PTM-0255);IRS1 is phosphorylated by JAK2 (Phosphotyrosine:PTM-0255);IRS1 is phosphorylated by ALK (Phosphotyrosine:PTM-0255);IRS1 is phosphorylated by IGF1R (Phosphotyrosine:PTM-0255);IRS1 is phosphorylated by PTK2 (Phosphotyrosine:PTM-0255);IRS1 is phosphorylated by INSRR (Phosphotyrosine:PTM-0255);IRS1 is phosphorylated by RPS6KB2	NA	Neurotrophin signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Interleukin-7 signaling;Growth hormone receptor signaling;IRS activation;Signal attenuation;IRS-related events triggered by IGF1R;Signaling by Leptin;SOS-mediated signalling;PI3K/AKT activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS-mediated signalling;Activated NTRK3 signals through PI3K	PE1	2
+NX_P35573	Glycogen debranching enzyme	1532	174764	6.31	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	Glycogen storage disease 3	Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.	The N-terminus is blocked.;Ubiquitinated.	Belongs to the glycogen debranching enzyme family.	Starch and sucrose metabolism;Metabolic pathways;Glycogen breakdown (glycogenolysis);Neutrophil degranulation	PE1	1
+NX_P35575	Glucose-6-phosphatase	357	40484	8.72	9	Endoplasmic reticulum membrane	Glycogen storage disease 1A	Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.	NA	Belongs to the glucose-6-phosphatase family.	Carbohydrate biosynthesis; gluconeogenesis.;Glycolysis / Gluconeogenesis;Galactose metabolism;Starch and sucrose metabolism;Metabolic pathways;Insulin signaling pathway;Adipocytokine signaling pathway;Carbohydrate digestion and absorption;Gluconeogenesis;Glycogen storage disease type Ia (G6PC);FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	17
+NX_P35579	Myosin-9	1960	226532	5.5	0	Cytosol;Cell cortex;Cytoskeleton;Cell membrane	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss;Deafness, autosomal dominant, 17	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.	Ubiquitination.;ISGylated.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tight junction;Regulation of actin cytoskeleton;Salmonella infection;Viral myocarditis;Regulation of actin dynamics for phagocytic cup formation;Translocation of SLC2A4 (GLUT4) to the plasma membrane;EPHA-mediated growth cone collapse;RHO GTPases activate PKNs;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate CIT;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs	PE1	22
+NX_P35580	Myosin-10	1976	228999	5.44	0	Cytosol;Lamellipodium;Mitochondrion;Cytoskeleton	NA	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.	Phosphorylated by ABL2.;MYH10 is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255);MYH10 is phosphorylated by ABL2 (Phosphotyrosine:PTM-0255);MYH10 is phosphorylated by PRKCG (Phosphoserine:PTM-0253)	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tight junction;Regulation of actin cytoskeleton;Salmonella infection;Viral myocarditis;EPHA-mediated growth cone collapse;RHO GTPases activate PKNs;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate CIT;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs	PE1	17
+NX_P35590	Tyrosine-protein kinase receptor Tie-1	1138	125090	6.63	1	Cell membrane	NA	Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.	Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.;TIE1 is phosphorylated by TEK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.	NA	PE1	1
+NX_P35606	Coatomer subunit beta'	906	102487	5.15	0	Golgi apparatus;Cytoplasm;COPI-coated vesicle membrane;Golgi apparatus membrane;Cytosol	Microcephaly 19, primary, autosomal recessive	This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity).;The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).	NA	Belongs to the WD repeat COPB2 family.	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	3
+NX_P35609	Alpha-actinin-2	894	103854	5.31	0	Z line	Cardiomyopathy, familial hypertrophic 23, with or without left ventricular non-compaction;Cardiomyopathy, dilated 1AA, with or without left ventricular non-compaction	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.	Ubiquitinated by FBXL22, leading to proteasomal degradation.	Belongs to the alpha-actinin family.	Focal adhesion;Adherens junction;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Amoebiasis;Systemic lupus erythematosus;Arrhythmogenic right ventricular cardiomyopathy (ARVC);RAF/MAP kinase cascade;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;Platelet degranulation;Striated Muscle Contraction;Nephrin family interactions;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	1
+NX_P35610	Sterol O-acyltransferase 1	550	64735	9.08	5	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.	NA	Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.	Steroid biosynthesis;LDL clearance	PE1	1
+NX_P35611	Alpha-adducin	737	80955	5.6	0	Nucleoplasm;Cell membrane;Cytoskeleton	NA	Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.	ADD1 is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the aldolase class II family. Adducin subfamily.	XBP1(S) activates chaperone genes;Caspase-mediated cleavage of cytoskeletal proteins;Miscellaneous transport and binding events	PE1	4
+NX_P35612	Beta-adducin	726	80854	5.67	0	Nucleoplasm;Cytosol;Cytoskeleton;Cell membrane	NA	Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.	The N-terminus is blocked.	Belongs to the aldolase class II family. Adducin subfamily.	Miscellaneous transport and binding events	PE1	2
+NX_P35613	Basigin	385	42200	5.39	1	Cytoplasmic vesicle;Melanosome;Cell membrane	NA	Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:21778275). Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.	N-glycosylated.	NA	Degradation of the extracellular matrix;Pyruvate metabolism;Integrin cell surface interactions;Basigin interactions;Proton-coupled monocarboxylate transport;Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	PE1	19
+NX_P35625	Metalloproteinase inhibitor 3	211	24145	9	0	Extracellular matrix	Sorsby fundus dystrophy	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.	NA	Belongs to the protease inhibitor I35 (TIMP) family.	Platelet degranulation	PE1	22
+NX_P35626	Beta-adrenergic receptor kinase 2	688	79710	7.55	0	Nucleoplasm;Cell membrane	NA	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.	Ubiquitinated.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Chemokine signaling pathway;Endocytosis;Glutamatergic synapse;Olfactory transduction;G alpha (s) signalling events;Cargo recognition for clathrin-mediated endocytosis	PE1	22
+NX_P35637	RNA-binding protein FUS	526	53426	9.4	0	Nucleoplasm;Nucleus	Tremor, hereditary essential 4;Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia;Angiomatoid fibrous histiocytoma	DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).	Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine.;Phosphorylated in its N-terminal serine residues upon induced DNA damage. ATM and DNA-PK are able to phosphorylate FUS N-terminal region.	Belongs to the RRM TET family.	mRNA Splicing - Major Pathway	PE1	16
+NX_P35638	DNA damage-inducible transcript 3 protein	169	19175	4.61	0	Nucleoplasm;Cytoplasm;Nucleus	Myxoid liposarcoma	Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.	Ubiquitinated, leading to its degradation by the proteasome.;Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.	Belongs to the bZIP family.	MAPK signaling pathway;Protein processing in endoplasmic reticulum;ATF4 activates genes in response to endoplasmic reticulum stress;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes	PE1	12
+NX_P35658	Nuclear pore complex protein Nup214	2090	213620	7.15	0	Cytoplasmic vesicle;Nucleoplasm;Focal adhesion;Nuclear pore complex	NA	May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.	Probably glycosylated as it reacts with wheat germ agglutinin (WGA).	NA	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;HuR (ELAVL1) binds and stabilizes mRNA;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	9
+NX_P35659	Protein DEK	375	42674	8.69	0	Nucleoplasm;Nucleus	NA	Involved in chromatin organization.	Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.	NA	B-WICH complex positively regulates rRNA expression;Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors;Transcriptional regulation of granulopoiesis	PE1	6
+NX_P35663	Cylicin-1	651	74242	9.68	0	Calyx	NA	Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.	NA	NA	NA	PE1	X
+NX_P35670	Copper-transporting ATPase 2	1465	157263	6.25	8	Cytoplasm;Golgi apparatus;Mitochondrion;trans-Golgi network membrane;Late endosome;Golgi apparatus membrane	Wilson disease	Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.	May be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form.	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.	Ion transport by P-type ATPases	PE1	13
+NX_P35680	Hepatocyte nuclear factor 1-beta	557	61324	7.39	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	Prostate cancer, hereditary, 11;Diabetes mellitus, non-insulin-dependent;Renal cysts and diabetes syndrome	Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.	NA	Belongs to the HNF1 homeobox family.	Maturity onset diabetes of the young;Regulation of gene expression in early pancreatic precursor cells;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	PE1	17
+NX_P35711	Transcription factor SOX-5	763	84026	6.15	0	Nucleoplasm;Nucleus	Lamb-Shaffer syndrome	Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro.	NA	NA	NA	PE1	12
+NX_P35712	Transcription factor SOX-6	828	91921	7.65	0	Nucleoplasm;Nucleus	NA	Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation.	Sumoylation inhibits the transcriptional activity.	NA	Deactivation of the beta-catenin transactivating complex	PE1	11
+NX_P35713	Transcription factor SOX-18	384	40891	8.16	0	Nucleoplasm;Nucleus	Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome;Hypotrichosis-lymphedema-telangiectasia syndrome	Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development.	NA	NA	NA	PE1	20
+NX_P35716	Transcription factor SOX-11	441	46679	4.91	0	Nucleoplasm;Nucleus	Mental retardation, autosomal dominant 27	Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development.	NA	NA	NA	PE1	2
+NX_P35749	Myosin-11	1972	227339	5.42	0	Cytosol;Melanosome;Cell membrane	Aortic aneurysm, familial thoracic 4	Muscle contraction.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Vascular smooth muscle contraction;Tight junction;Viral myocarditis;EPHA-mediated growth cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate CIT;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs	PE1	16
+NX_P35754	Glutaredoxin-1	106	11776	8.33	0	Cytoplasm;Cytosol;Cell membrane	NA	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.	NA	Belongs to the glutaredoxin family.	Interconversion of nucleotide di- and triphosphates	PE1	5
+NX_P35789	Zinc finger protein 93	620	70971	9.4	0	Nucleus	NA	Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P35790	Choline kinase alpha	457	52249	6.16	0	Endoplasmic reticulum;Cytoplasm	NA	Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.	NA	Belongs to the choline/ethanolamine kinase family.	Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.;Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PC;Synthesis of PE	PE1	11
+NX_P35813	Protein phosphatase 1A	382	42448	5.19	0	Membrane;Cytosol;Nucleus;Cell membrane	NA	Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.	N-myristoylation is essential for the recognition of its substrates for dephosphorylation.	Belongs to the PP2C family.	MAPK signaling pathway;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Energy dependent regulation of mTOR by LKB1-AMPK	PE1	14
+NX_P35858	Insulin-like growth factor-binding protein complex acid labile subunit	605	66035	6.33	0	Extracellular space	Acid-labile subunit deficiency	Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.	NA	NA	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	PE1	16
+NX_P35869	Aryl hydrocarbon receptor	848	96147	5.94	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Retinitis pigmentosa 85	Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Involved in cell-cycle regulation (PubMed:12213388). Likely to play an important role in the development and maturation of many tissues (PubMed:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).	Mono-ADP-ribosylated, leading to inhibit transcription activator activity of AHR.	NA	Xenobiotics;PPARA activates gene expression;Endogenous sterols;Phase I - Functionalization of compounds;Aryl hydrocarbon receptor signalling	PE1	7
+NX_P35900	Keratin, type I cytoskeletal 20	424	48487	5.52	0	Cytoplasm;Cytosol	NA	Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).	Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity).;Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_P35908	Keratin, type II cytoskeletal 2 epidermal	639	65433	8.07	0	Golgi apparatus;Cytosol;Cytoskeleton	Ichthyosis bullosa of Siemens	Probably contributes to terminal cornification (PubMed:1380918). Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329). Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_P35913	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	854	98336	5.11	0	Membrane;Cytosol	Retinitis pigmentosa 40;Night blindness, congenital stationary, autosomal dominant 2	This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.	NA	Belongs to the cyclic nucleotide phosphodiesterase family.	Purine metabolism;Phototransduction;Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Ca2+ pathway	PE1	4
+NX_P35914	Hydroxymethylglutaryl-CoA lyase, mitochondrial	325	34360	8.81	0	Peroxisome;Mitochondrion matrix	3-hydroxy-3-methylglutaryl-CoA lyase deficiency	Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.	NA	Belongs to the HMG-CoA lyase family.	Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation;Butanoate metabolism;Metabolic pathways;Peroxisome;Synthesis of Ketone Bodies;Peroxisomal protein import	PE1	1
+NX_P35916	Vascular endothelial growth factor receptor 3	1363	152757	5.9	1	Cytoplasm;Cell membrane;Cell junction;Secreted;Nucleoplasm;Nucleus	Lymphatic malformation 1;Hemangioma, capillary infantile	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.	Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. One subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation in response to H(2)O(2) is mediated by a process that requires SRC and PRKCD activity. Phosphorylation at Tyr-1068 is required for autophosphorylation at additional tyrosine residues. Phosphorylation at Tyr-1063 and Tyr-1337 is important for interaction with CRK and subsequent activation of MAPK8. Phosphorylation at Tyr-1230, Tyr-1231 and Tyr-1337 is important for interaction with GRB2 and subsequent activation of the AKT1 and MAPK1/ERK2 and/or MAPK3/ERK1 signaling pathways. In response to endothelial cell adhesion onto collagen, can also be phosphorylated in the absence of FLT4 kinase activity by SRC at Tyr-830, Tyr-833, Tyr-853, Tyr-1063, Tyr-1333, and Tyr-1337.;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Cytokine-cytokine receptor interaction;Focal adhesion;VEGF binds to VEGFR leading to receptor dimerization;NOTCH4 Intracellular Domain Regulates Transcription	PE1	5
+NX_P35968	Vascular endothelial growth factor receptor 2	1356	151527	5.6	1	Cytoplasm;Cell membrane;Early endosome;Cell junction;Secreted;Endoplasmic reticulum;Cytoplasmic vesicle;Nucleus	Hemangioma, capillary infantile	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD.;Plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.	N-glycosylated.;The inhibitory disulfide bond between Cys-1024 and Cys-1045 may serve as a specific molecular switch for H(2)S-induced modification that regulates VEGFR2 function.;Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. One subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-951 is important for interaction with SH2D2A/TSAD and VEGFA-mediated reorganization of the actin cytoskeleton. Phosphorylation at Tyr-1175 is important for interaction with PLCG1 and SHB. Phosphorylation at Tyr-1214 is important for interaction with NCK1 and FYN. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-1054, Tyr-1059, Tyr-1175 and Tyr-1214.;Ubiquitinated. Tyrosine phosphorylation of the receptor promotes its poly-ubiquitination, leading to its degradation via the proteasome or lysosomal proteases.;KDR is phosphorylated by FLT1 (Phosphotyrosine:PTM-0255);Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Cytokine-cytokine receptor interaction;Endocytosis;VEGF signaling pathway;Focal adhesion;VEGFA-VEGFR2 Pathway;Integrin cell surface interactions;VEGFR2 mediated cell proliferation;Neurophilin interactions with VEGF and VEGFR;VEGF binds to VEGFR leading to receptor dimerization	PE1	4
+NX_P35998	26S proteasome regulatory subunit 7	433	48634	5.71	0	Cytoplasm;Cytosol	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.	NA	Belongs to the AAA ATPase family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	7
+NX_P36021	Monocarboxylate transporter 8	539	59511	5.43	12	Cell membrane	Monocarboxylate transporter 8 deficiency	Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr.	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	Transport of organic anions	PE1	X
+NX_P36222	Chitinase-3-like protein 1	383	42625	8.69	0	Golgi apparatus;Cytoplasm;Endoplasmic reticulum;Extracellular space;Perinuclear region	Asthma-related traits 7;Schizophrenia	Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.	Glycosylated.	Belongs to the glycosyl hydrolase 18 family.	Amino sugar and nucleotide sugar metabolism;Neutrophil degranulation	PE1	1
+NX_P36268	Inactive glutathione hydrolase 2	569	61771	7.22	0	Endoplasmic reticulum;Perinuclear region	NA	Lack catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer.	Not cleaved by autocatalysis into a large and a small subunit resulting in loss of cell membrane localization and catalytic activity.	Belongs to the gamma-glutamyltransferase family.	NA	PE1	22
+NX_P36269	Glutathione hydrolase 5 proenzyme	586	62261	7.24	1	Membrane;Nucleolus	NA	Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).	Cleaved by autocatalysis into a large and a small subunit.	Belongs to the gamma-glutamyltransferase family.	Sulfur metabolism; glutathione metabolism.;Lipid metabolism; leukotriene D4 biosynthesis.;Taurine and hypotaurine metabolism;Cyanoamino acid metabolism;Glutathione metabolism;Arachidonic acid metabolism;Metabolic pathways;Aflatoxin activation and detoxification;Glutathione synthesis and recycling;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	22
+NX_P36382	Gap junction alpha-5 protein	358	40380	8.81	4	Gap junction;Cell membrane	Atrial standstill 1;Atrial fibrillation, familial, 11	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Alpha-type (group II) subfamily.	Gap junction assembly	PE1	1
+NX_P36383	Gap junction gamma-1 protein	396	45470	6.9	4	Cell membrane;Cell junction;Gap junction;Nucleolus;Cytosol	NA	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Gamma-type subfamily.	Electric Transmission Across Gap Junctions;Gap junction assembly	PE1	17
+NX_P36402	Transcription factor 7	384	41642	6.32	0	Nucleoplasm;Nucleus	NA	Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.	NA	Belongs to the TCF/LEF family.	Wnt signaling pathway;Adherens junction;Melanogenesis;Pathways in cancer;Colorectal cancer;Endometrial cancer;Prostate cancer;Thyroid cancer;Basal cell carcinoma;Acute myeloid leukemia;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Formation of the beta-catenin:TCF transactivating complex;Ca2+ pathway;Deactivation of the beta-catenin transactivating complex;Binding of TCF/LEF:CTNNB1 to target gene promoters;Repression of WNT target genes;RUNX3 regulates WNT signaling	PE1	5
+NX_P36404	ADP-ribosylation factor-like protein 2	184	20878	5.95	0	Golgi apparatus;Cytoplasm;Mitochondrion intermembrane space;Focal adhesion;Nucleolus;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.	Not N-myristoylated.	Belongs to the small GTPase superfamily. Arf family.	Post-chaperonin tubulin folding pathway;Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	PE1	11
+NX_P36405	ADP-ribosylation factor-like protein 3	182	20456	6.74	0	Cytoplasm;Cell membrane;Cilium;Nucleoplasm;Centrosome;Golgi apparatus membrane;Spindle;Nucleus	Joubert syndrome 35;Retinitis pigmentosa 83	Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:16525022, PubMed:18588884). Required for normal cytokinesis and cilia signaling (PubMed:22085962). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E (PubMed:30269812). Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (PubMed:22085962). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity).	NA	Belongs to the small GTPase superfamily. Arf family.	Trafficking of myristoylated proteins to the cilium	PE1	10
+NX_P36406	E3 ubiquitin-protein ligase TRIM23	574	64067	5.93	0	Cytoplasm;Endomembrane system;Lysosome membrane;Golgi apparatus membrane	NA	Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).;(Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection.	NA	In the C-terminal section; belongs to the small GTPase superfamily. Arf family.	Protein modification; protein ubiquitination.	PE1	5
+NX_P36507	Dual specificity mitogen-activated protein kinase kinase 2	400	44424	6.12	0	Membrane;Cytoplasm;Cytosol	Cardiofaciocutaneous syndrome 4	Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126).	MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity).;Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	MAPK signaling pathway;ErbB signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Gap junction;Toll-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Long-term depression;Regulation of actin cytoskeleton;Insulin signaling pathway;GnRH signaling pathway;Melanogenesis;Prion diseases;Influenza A;Pathways in cancer;Renal cell carcinoma;Endometrial cancer;Glioma;Prostate cancer;Thyroid cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;Uptake and function of anthrax toxins;Signal transduction by L1;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;MAPK1 (ERK2) activation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	19
+NX_P36508	Zinc finger protein 76	570	61831	5.66	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_P36537	UDP-glucuronosyltransferase 2B10	528	60774	9.12	1	Microsome membrane;Endoplasmic reticulum membrane	NA	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	4
+NX_P36542	ATP synthase subunit gamma, mitochondrial	298	32996	9.23	0	Cytoplasm;Mitochondrion inner membrane	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.	NA	Belongs to the ATPase gamma chain family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	10
+NX_P36543	V-type proton ATPase subunit E 1	226	26145	7.7	0	Nucleoplasm	Cutis laxa, autosomal recessive, 2C	Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	NA	Belongs to the V-ATPase E subunit family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	22
+NX_P36544	Neuronal acetylcholine receptor subunit alpha-7	502	56449	6.02	4	Cell membrane;Postsynaptic cell membrane	NA	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Cholinergic synapse;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	PE1	15
+NX_P36551	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	454	50152	8.59	0	Mitochondrion intermembrane space;Mitochondrion	Hereditary coproporphyria	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.	NA	Belongs to the aerobic coproporphyrinogen-III oxidase family.	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.;Porphyrin and chlorophyll metabolism;Metabolic pathways;Heme biosynthesis	PE1	3
+NX_P36575	Arrestin-C	388	42778	5.53	0	Photoreceptor inner segment;Photoreceptor outer segment	Myopia 26, X-linked, female-limited	May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.	NA	Belongs to the arrestin family.	NA	PE1	X
+NX_P36578	60S ribosomal protein L4	427	47697	11.07	0	Endoplasmic reticulum;Nucleus;Nucleolus;Cytosol	NA	NA	Citrullinated by PADI4.	Belongs to the universal ribosomal protein uL4 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	15
+NX_P36639	7,8-dihydro-8-oxoguanine triphosphatase	197	22520	5.15	0	Mitochondrion matrix;Nucleus;Cytosol	NA	Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900). Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress (PubMed:12857738, PubMed:24695224, PubMed:24695225). Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (PubMed:10373420, PubMed:11139615). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).	The N-terminus is blocked.	Belongs to the Nudix hydrolase family.	Phosphate bond hydrolysis by NUDT proteins	PE1	7
+NX_P36776	Lon protease homolog, mitochondrial	959	106489	6.01	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	CODAS syndrome	ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. BL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575).	NA	Belongs to the peptidase S16 family.	NA	PE1	19
+NX_P36871	Phosphoglucomutase-1	562	61449	6.3	0	Cytoplasm	Congenital disorder of glycosylation 1T	This enzyme participates in both the breakdown and synthesis of glucose.	Phosphorylation at Thr-467 by PAK1 significantly enhances enzymatic activity.	Belongs to the phosphohexose mutase family.	Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Galactose metabolism;Purine metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Glycogen synthesis;Defective PGM1 causes PGM1-CDG (CDG1t);Neutrophil degranulation	PE1	1
+NX_P36873	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	323	36984	6.12	0	Cytoplasm;Mitochondrion;Cleavage furrow;Nucleus speckle;Nucleolus;Midbody;Nucleoplasm;Nucleus;Kinetochore	NA	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).	Phosphorylated by NEK2.	Belongs to the PPP phosphatase family. PP-1 subfamily.	Oocyte meiosis;Vascular smooth muscle contraction;Focal adhesion;Long-term potentiation;Dopaminergic synapse;Regulation of actin cytoskeleton;Insulin signaling pathway;Herpes simplex infection;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Triglyceride catabolism;Circadian Clock;Downregulation of TGF-beta receptor signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	12
+NX_P36888	Receptor-type tyrosine-protein kinase FLT3	993	112903	5.48	1	Membrane;Endoplasmic reticulum;Endoplasmic reticulum lumen	Leukemia, acute myelogenous	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.	N-glycosylated, contains complex N-glycans with sialic acid.;Rapidly ubiquitinated by UBE2L6 and the E3 ubiquitin-protein ligase SIAH1 after autophosphorylation, leading to its proteasomal degradation.;Autophosphorylated on several tyrosine residues in response to FLT3LG binding. FLT3LG binding also increases phosphorylation of mutant kinases that are constitutively activated. Dephosphorylated by PTPRJ/DEP-1, PTPN1, PTPN6/SHP-1, and to a lesser degree by PTPN12. Dephosphorylation is important for export from the endoplasmic reticulum and location at the cell membrane.;Autophosphorylated (Phosphotyrosine:PTM-0255);FLT3 is phosphorylated by FYN (Phosphotyrosine:PTM-0255);FLT3 is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Cytokine-cytokine receptor interaction;Hematopoietic cell lineage;Pathways in cancer;Acute myeloid leukemia;RAF/MAP kinase cascade;PI3K Cascade;FLT3 Signaling;STAT5 Activation	PE1	13
+NX_P36894	Bone morphogenetic protein receptor type-1A	532	60198	7.71	1	Cell surface;Cytosol;Cell membrane	Juvenile polyposis syndrome;Polyposis syndrome, mixed hereditary 2	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.	Glycosylated.	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Signaling by BMP	PE1	10
+NX_P36896	Activin receptor type-1B	505	56807	6.6	1	Cytosol;Cell membrane	NA	Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.	Ubiquitinated.;Autophosphorylated. Phosphorylated by activin receptor type-2 (ACVR2A or ACVR2B) in response to activin-binding at serine and threonine residues in the GS domain. Phosphorylation of ACVR1B by activin receptor type-2 regulates association with SMAD7.;Ubiquitinated. Level of ubiquitination is regulated by the SMAD7-SMURF1 complex.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);ACVR1B is phosphorylated by ACVR2B (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Cytokine-cytokine receptor interaction;Signaling by NODAL;Signaling by Activin;Regulation of signaling by NODAL	PE1	12
+NX_P36897	TGF-beta receptor type-1	503	55960	7.51	1	Cell surface;Tight junction;Membrane raft;Cell membrane	Loeys-Dietz syndrome 1;Multiple self-healing squamous epithelioma	Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.	N-Glycosylated.;Phosphorylated at basal levels in the absence of ligand. Activated upon phosphorylation by TGFBR2, mainly in the GS domain. Phosphorylation in the GS domain abrogates FKBP1A-binding.;Ubiquitinated; undergoes ubiquitination catalyzed by several E3 ubiquitin ligases including SMURF1, SMURF2 and NEDD4L2. Results in the proteasomal and/or lysosomal degradation of the receptor thereby negatively regulating its activity. Deubiquitinated by USP15, leading to stabilization of the protein and enhanced TGF-beta signal. Its ubiquitination and proteasome-mediated degradation is negatively regulated by SDCBP (PubMed:25893292).	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Endocytosis;TGF-beta signaling pathway;Osteoclast differentiation;Adherens junction;Chagas disease (American trypanosomiasis);HTLV-I infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Chronic myeloid leukemia;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;SMAD2/3 Phosphorylation Motif Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;UCH proteinases;Ub-specific processing proteases	PE1	9
+NX_P36915	Guanine nucleotide-binding protein-like 1	607	68661	5.57	0	Cytoplasmic vesicle	NA	Possible regulatory or functional link with the histocompatibility cluster.	NA	Belongs to the TRAFAC class YlqF/YawG GTPase family.	NA	PE1	6
+NX_P36941	Tumor necrosis factor receptor superfamily member 3	435	46709	5.53	1	Membrane;Golgi apparatus	NA	Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.	NA	NA	Cytokine-cytokine receptor interaction;Intestinal immune network for IgA production;HTLV-I infection;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	PE1	12
+NX_P36952	Serpin B5	375	42100	5.72	0	Cytoplasmic vesicle;Extracellular space	NA	Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.	NA	Belongs to the serpin family. Ov-serpin subfamily.	p53 signaling pathway	PE1	18
+NX_P36954	DNA-directed RNA polymerase II subunit RPB9	125	14523	5.04	0	Nucleoplasm;Nucleolus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).	NA	Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Huntington's disease;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;MicroRNA (miRNA) biogenesis;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	19
+NX_P36955	Pigment epithelium-derived factor	418	46312	5.97	0	Melanosome;Secreted	Osteogenesis imperfecta 6	Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.	N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.;The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.	Belongs to the serpin family.	NA	PE1	17
+NX_P36956	Sterol regulatory element-binding protein 1	1147	121675	8.43	2	Golgi apparatus;Endoplasmic reticulum membrane;COPII-coated vesicle membrane;Golgi apparatus membrane;Cytosol;Nucleus	NA	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').	Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-402 by SIK1 represses activity possibly by inhibiting DNA-binding (By similarity).;At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.;SREBF1 is phosphorylated by GSK3B (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the SREBP family.	Insulin signaling pathway;PPARA activates gene expression;RORA activates gene expression;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of cholesterol biosynthesis by SREBP (SREBF);FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	17
+NX_P36957	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial	453	48755	9.1	0	Mitochondrion matrix;Nucleus	NA	Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).	NA	Belongs to the 2-oxoacid dehydrogenase family.	Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.;Citrate cycle (TCA cycle);Lysine degradation;Metabolic pathways;Citric acid cycle (TCA cycle);Lysine catabolism;Glyoxylate metabolism and glycine degradation	PE1	14
+NX_P36959	GMP reductase 1	345	37419	6.6	0	NA	NA	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	NA	Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.	Purine metabolism;Purine salvage	PE1	6
+NX_P36969	Phospholipid hydroperoxide glutathione peroxidase	197	22175	8.69	0	Cytoplasm;Nucleoplasm;Mitochondrion	Spondylometaphyseal dysplasia, Sedaghatian type	Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:24439385). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity).	NA	Belongs to the glutathione peroxidase family.	Glutathione metabolism;Synthesis of 15-eicosatetraenoic acid derivatives;Synthesis of 12-eicosatetraenoic acid derivatives;Synthesis of 5-eicosatetraenoic acids;Biosynthesis of D-series resolvins;Biosynthesis of E-series 18(S)-resolvins;Biosynthesis of aspirin-triggered D-series resolvins;Biosynthesis of E-series 18(R)-resolvins	PE1	19
+NX_P36980	Complement factor H-related protein 2	270	30651	6	0	Secreted	NA	Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.	N-glycosylated.	NA	Regulation of Complement cascade	PE1	1
+NX_P37023	Serine/threonine-protein kinase receptor R3	503	56124	7.56	1	Cell membrane	Telangiectasia, hereditary hemorrhagic, 2	Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.	NA	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Signaling by BMP	PE1	12
+NX_P37058	Testosterone 17-beta-dehydrogenase 3	310	34516	8.9	0	Endoplasmic reticulum;Cytoplasmic vesicle	Male pseudohermaphrodism with gynecomastia	Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.	Hormone biosynthesis; testosterone biosynthesis.;Steroid hormone biosynthesis;Metabolic pathways;Synthesis of very long-chain fatty acyl-CoAs;Androgen biosynthesis	PE1	9
+NX_P37059	Estradiol 17-beta-dehydrogenase 2	387	42785	8.79	1	Membrane;Endoplasmic reticulum	NA	Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Steroid hormone biosynthesis;Metabolic pathways;Estrogen biosynthesis	PE1	16
+NX_P37088	Amiloride-sensitive sodium channel subunit alpha	669	75704	7.47	2	Cytoplasm;Cilium;Flagellum;Apical cell membrane;Cytoplasmic granule;Acrosome	Bronchiectasis with or without elevated sweat chloride 2;Pseudohypoaldosteronism 1, autosomal recessive;Liddle syndrome 3	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.	N-glycosylated.;Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.;ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.	Taste transduction;Aldosterone-regulated sodium reabsorption;Stimuli-sensing channels	PE1	12
+NX_P37108	Signal recognition particle 14 kDa protein	136	14570	10.05	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.	NA	Belongs to the SRP14 family.	Protein export;SRP-dependent cotranslational protein targeting to membrane;Neutrophil degranulation	PE1	15
+NX_P37173	TGF-beta receptor type-2	567	64568	5.6	1	Membrane raft;Cell membrane	Hereditary non-polyposis colorectal cancer 6;Esophageal cancer;Loeys-Dietz syndrome 2	Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.	Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.;Autophosphorylated (Phosphoserine:PTM-0253)	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Endocytosis;TGF-beta signaling pathway;Osteoclast differentiation;Adherens junction;Chagas disease (American trypanosomiasis);HTLV-I infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Chronic myeloid leukemia;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;SMAD2/3 Phosphorylation Motif Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;TGFBR2 MSI Frameshift Mutants in Cancer;UCH proteinases	PE1	3
+NX_P37198	Nuclear pore glycoprotein p62	522	53255	5.21	0	Nuclear pore complex;Nucleus membrane;Nucleoplasm;Spindle pole;Centrosome;Nucleus envelope	Infantile striatonigral degeneration	Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630).	O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, among which only one in the C-terminal.;The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.	Belongs to the nucleoporin NSP1/NUP62 family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	19
+NX_P37231	Peroxisome proliferator-activated receptor gamma	505	57620	5.61	0	Cytoplasmic vesicle;Nucleoplasm;Cytoplasm;Nucleus	Glioma 1;Lipodystrophy, familial partial, 3;Obesity	(Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein.;Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).	Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity (By similarity).;O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes.	Belongs to the nuclear hormone receptor family. NR1 subfamily.	PPAR signaling pathway;Osteoclast differentiation;Huntington's disease;Pathways in cancer;Thyroid cancer;PPARA activates gene expression;Nuclear Receptor transcription pathway;Transcriptional regulation of white adipocyte differentiation;Regulation of PTEN gene transcription;SUMOylation of intracellular receptors;MECP2 regulates transcription factors	PE1	3
+NX_P37235	Hippocalcin-like protein 1	193	22313	5.21	0	Membrane	NA	May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.	NA	Belongs to the recoverin family.	NA	PE1	2
+NX_P37268	Squalene synthase	417	48115	6.1	2	Endoplasmic reticulum;Endoplasmic reticulum membrane	Squalene synthase deficiency	NA	NA	Belongs to the phytoene/squalene synthase family.	Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.;Steroid biosynthesis;Metabolic pathways;PPARA activates gene expression;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	8
+NX_P37275	Zinc finger E-box-binding homeobox 1	1124	124074	4.87	0	Nucleoplasm;Nucleus	Corneal dystrophy, Fuchs endothelial, 6;Corneal dystrophy, posterior polymorphous, 3	Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.	NA	Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.	Interleukin-4 and Interleukin-13 signaling	PE1	10
+NX_P37287	Phosphatidylinositol N-acetylglucosaminyltransferase subunit A	484	54127	8.63	1	Endoplasmic reticulum membrane	Multiple congenital anomalies-hypotonia-seizures syndrome 2;Paroxysmal nocturnal hemoglobinuria 1	Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.	NA	Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	X
+NX_P37288	Vasopressin V1a receptor	418	46800	9.48	7	Cell membrane	NA	Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.	NA	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;G alpha (q) signalling events;Vasopressin-like receptors;Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)	PE1	12
+NX_P37802	Transgelin-2	199	22391	8.41	0	Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the calponin family.	Platelet degranulation	PE1	1
+NX_P37837	Transaldolase	337	37540	6.36	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Transaldolase deficiency	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	NA	Belongs to the transaldolase family. Type 1 subfamily.	Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.;Pentose phosphate pathway;Metabolic pathways;Pentose phosphate pathway;Insulin effects increased synthesis of Xylulose-5-Phosphate;TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P;TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	11
+NX_P37840	Alpha-synuclein	140	14460	4.67	0	Cytoplasm;Secreted;Membrane;Synapse;Nucleus	Parkinson disease 1, autosomal dominant;Parkinson disease 4, autosomal dominant;Dementia, Lewy body	Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).	Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.;Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress.;Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity).;Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.	Belongs to the synuclein family.	Alzheimer's disease;Parkinson's disease;Amyloid fiber formation	PE1	4
+NX_P38117	Electron transfer flavoprotein subunit beta	255	27844	8.25	0	Cytoplasm;Mitochondrion matrix;Mitochondrion	Glutaric aciduria 2B	Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:25416781, PubMed:15159392, PubMed:15975918). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:8962055, PubMed:15159392, PubMed:15975918).	Methylated. Trimethylation at Lys-200 and Lys-203 may negatively regulate the activity in electron transfer from acyl-CoA dehydrogenases.	Belongs to the ETF beta-subunit/FixA family.	Respiratory electron transport;Protein methylation	PE1	19
+NX_P38159	RNA-binding motif protein, X chromosome	391	42332	10.06	0	Nucleus	Mental retardation, X-linked, syndromic, 11	RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.	Arg-185 is dimethylated, probably to asymmetric dimethylarginine.;O-glycosylated.;Cleavage of initiator Met is partial. If Met-1 is not removed, it is acetylated. If it is removed, Val-2 is acetylated.	NA	Spliceosome;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA	PE1	X
+NX_P38398	Breast cancer type 1 susceptibility protein	1863	207721	5.29	0	Nucleoplasm;Cytoplasm;Nucleus;Chromosome	Breast-ovarian cancer, familial, 1;Fanconi anemia, complementation group S;Breast cancer;Pancreatic cancer 4;Ovarian cancer	E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed:20160719).	Phosphorylation at Ser-308 by AURKA is required for normal cell cycle progression from G2 to mitosis. Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or ATR. Phosphorylation at Ser-988 by CHEK2 regulates mitotic spindle assembly.;Autoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote degradation.;BRCA1 is phosphorylated by CHEK1;BRCA1 is phosphorylated by CHEK2;BRCA1 is phosphorylated by CDK4	NA	Protein modification; protein ubiquitination.;Fanconi anemia pathway;Ubiquitin mediated proteolysis;SUMOylation of DNA damage response and repair proteins;Meiotic synapsis;Meiotic recombination;G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Nonhomologous End-Joining (NHEJ);TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;Metalloprotease DUBs;Transcriptional Regulation by E2F6	PE1	17
+NX_P38405	Guanine nucleotide-binding protein G(olf) subunit alpha	381	44308	6.23	0	Nucleoplasm;Cytosol	Dystonia 25	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.	NA	Belongs to the G-alpha family. G(s) subfamily.	Calcium signaling pathway;Dopaminergic synapse;Olfactory transduction;Chagas disease (American trypanosomiasis);Amoebiasis;Olfactory Signaling Pathway;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway	PE1	18
+NX_P38432	Coilin	576	62608	9.2	0	Cajal body;Nucleoplasm;Nucleolus;Nucleus	NA	Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.	Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs.;Phosphorylation during mitosis is associated with disassembly of CBs.	Belongs to the coilin family.	NA	PE1	17
+NX_P38435	Vitamin K-dependent gamma-carboxylase	758	87561	8.17	5	Endoplasmic reticulum membrane	Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency;Combined deficiency of vitamin K-dependent clotting factors 1	Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.	NA	Belongs to the vitamin K-dependent gamma-carboxylase family.	Gamma-carboxylation of protein precursors	PE1	2
+NX_P38484	Interferon gamma receptor 2	337	37806	5.27	1	Golgi apparatus;Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Cytoplasmic vesicle membrane;Nucleoplasm;Golgi apparatus membrane	Immunodeficiency 28	Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114).	NA	Belongs to the type II cytokine receptor family.	Cytokine-cytokine receptor interaction;Osteoclast differentiation;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Salmonella infection;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Measles;Influenza A;Herpes simplex infection;Interferon gamma signaling;Regulation of IFNG signaling	PE1	21
+NX_P38567	Hyaluronidase PH-20	509	57848	6.62	0	Cell membrane	NA	Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.	N-glycosylated.	Belongs to the glycosyl hydrolase 56 family.	Glycosaminoglycan degradation;Metabolic pathways;Interaction With Cumulus Cells And The Zona Pellucida	PE1	7
+NX_P38570	Integrin alpha-E	1179	130159	5.48	1	Membrane	NA	Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.	NA	Belongs to the integrin alpha chain family.	Regulation of actin cytoskeleton;Integrin cell surface interactions	PE1	17
+NX_P38571	Lysosomal acid lipase/cholesteryl ester hydrolase	399	45419	6.42	0	Cytoplasmic vesicle;Lysosome	Wolman disease;Cholesteryl ester storage disease	Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Steroid biosynthesis;Lysosome;LDL clearance	PE1	10
+NX_P38606	V-type proton ATPase catalytic subunit A	617	68304	5.35	0	Nucleoplasm;Cytosol;Cytoplasm;Cytoplasmic vesicle	Cutis laxa, autosomal recessive, 2D;Epileptic encephalopathy, infantile or early childhood, 3	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857).	NA	Belongs to the ATPase alpha/beta chains family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	3
+NX_P38646	Stress-70 protein, mitochondrial	679	73680	5.87	0	Mitochondrion;Nucleolus	Even-plus syndrome;Anemia, sideroblastic, 4	Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity).	NA	Belongs to the heat shock protein 70 family.	RNA degradation;Tuberculosis;Mitochondrial protein import;Regulation of HSF1-mediated heat shock response;Cristae formation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	5
+NX_P38919	Eukaryotic initiation factor 4A-III	411	46871	6.3	0	Cytoplasm;Nucleoplasm;Nucleus speckle;Nucleus	Richieri-Costa-Pereira syndrome	ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:16209946, PubMed:16170325, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly (PubMed:22203037). Involved in craniofacial development (PubMed:24360810).	NA	Belongs to the DEAD box helicase family. eIF4A subfamily.	RNA transport;mRNA surveillance pathway;Spliceosome;ISG15 antiviral mechanism;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Deadenylation of mRNA;Regulation of expression of SLITs and ROBOs;RNA Polymerase II Transcription Termination	PE1	17
+NX_P38935	DNA-binding protein SMUBP-2	993	109149	9.13	0	Nucleoplasm;Cytoplasm;Axon;Nucleus	Charcot-Marie-Tooth disease 2S;Neuronopathy, distal hereditary motor, 6	5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV.	NA	Belongs to the DNA2/NAM7 helicase family.	NA	PE1	11
+NX_P38936	Cyclin-dependent kinase inhibitor 1	164	18119	8.69	0	Nucleoplasm;Cytoplasm;Nucleus	NA	May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).	Ubiquitinated by MKRN1; leading to polyubiquitination and 26S proteasome-dependent degradation. Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase or following UV irradiation. Ubiquitination by the DCX(DTL) complex is essential to control replication licensing and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Ubiquitination at Ser-2 leads to degradation by the proteasome pathway. Ubiquitinated by RNF114; leading to proteasomal degradation.;Acetylation leads to protein stability. Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163. Deacetylation by HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1 (By similarity).;Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-145 by PIM2 enhances CDKN1A stability and inhibits cell proliferation. Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. UV radiation-induced phosphorylation at Thr-80 by LKB1 and at Ser-146 by NUAK1 leads to its degradation.	Belongs to the CDI family.	ErbB signaling pathway;Cell cycle;p53 signaling pathway;Hepatitis C;HTLV-I infection;Pathways in cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SCF(Skp2)-mediated degradation of p27/p21;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry;Constitutive Signaling by AKT1 E17K in Cancer;Cyclin D associated events in G1;AKT phosphorylates targets in the cytosol;p53-Dependent G1 DNA Damage Response;Transcriptional activation of cell cycle inhibitor p21;The role of GTSE1 in G2/M progression after G2 checkpoint;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;TFAP2 (AP-2) family regulates transcription of cell cycle factors;Interleukin-4 and Interleukin-13 signaling;RUNX3 regulates CDKN1A transcription;Transcriptional regulation by RUNX2;FOXO-mediated transcription of cell cycle genes;Transcriptional regulation of granulopoiesis	PE1	6
+NX_P39019	40S ribosomal protein S19	145	16060	10.31	0	Nucleoplasm;Nucleus	Diamond-Blackfan anemia 1	Required for pre-rRNA processing and maturation of 40S ribosomal subunits.	NA	Belongs to the eukaryotic ribosomal protein eS19 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_P39023	60S ribosomal protein L3	403	46109	10.19	0	Cytoplasm;Cytosol;Nucleolus	NA	The L3 protein is a component of the large subunit of cytoplasmic ribosomes.	NA	Belongs to the universal ribosomal protein uL3 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	22
+NX_P39059	Collagen alpha-1(XV) chain	1388	141720	4.9	0	Endoplasmic reticulum;Extracellular matrix	NA	Restin potently inhibits angiogenesis.;Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.	O-glycosylated; with core 1 or possibly core 8 glycans. An N-terminal peptide contains chondroitin sulfate.;Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the multiplexin collagen family.	Protein digestion and absorption;Collagen degradation;Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	9
+NX_P39060	Collagen alpha-1(XVIII) chain	1754	178188	5.67	0	Golgi apparatus;Basement membrane;Extracellular matrix;Secreted	Knobloch syndrome 1	Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.;Non-collagenous domain 1: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling.;Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295). May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123).	Undergoes proteolytic processing by cathepsin-L and elastase-like proteases to generate both NC1 trimers and endostatin monomers (PubMed:10626789). In vitro, several proteolytic cleavage sites in the non-collagenous domain 1 hinge region generating different endostatin-like peptides are reported (By similarity).;Circulating endostatins are found as sialoglycoprotein and asialoglycoprotein structures.;Prolines at the third position of the tripeptide repeating unit (G-X-Y) of the triple-helical regions are hydroxylated.	Belongs to the multiplexin collagen family.	Protein digestion and absorption;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;Assembly of collagen fibrils and other multimeric structures;Activation of Matrix Metalloproteinases;Laminin interactions;Collagen chain trimerization	PE1	21
+NX_P39086	Glutamate receptor ionotropic, kainate 1	918	103981	6.65	3	Cell membrane;Postsynaptic cell membrane	NA	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.	NA	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;Activation of Ca-permeable Kainate Receptor;Activation of Na-permeable kainate receptors	PE1	21
+NX_P39210	Protein Mpv17	176	19733	9.54	4	Mitochondrion inner membrane	Charcot-Marie-Tooth disease, axonal, 2EE;Mitochondrial DNA depletion syndrome 6	Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (PubMed:25861990). Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (PubMed:26760297). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity).	NA	Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisome;Peroxisomal protein import	PE1	2
+NX_P39656	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit	456	50801	6.09	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	Congenital disorder of glycosylation 1R	Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation.;Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (PubMed:22467853).	NA	Belongs to the DDOST 48 kDa subunit family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;Advanced glycosylation endproduct receptor signaling;SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation;Neutrophil degranulation	PE1	1
+NX_P39687	Acidic leucine-rich nuclear phosphoprotein 32 family member A	249	28585	3.99	0	Endoplasmic reticulum;Cytoplasm;Nucleus	NA	Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.	Phosphorylated on serine residues.;The N-terminus is blocked.;Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).	Belongs to the ANP32 family.	HuR (ELAVL1) binds and stabilizes mRNA	PE1	15
+NX_P39748	Flap endonuclease 1	380	42593	8.8	0	Nucleoplasm;Mitochondrion;Nucleolus	NA	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.	Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.;Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.;Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.	Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.	POLB-Dependent Long Patch Base Excision Repair;PCNA-Dependent Long Patch Base Excision Repair;Removal of the Flap Intermediate from the C-strand;Removal of the Flap Intermediate;Early Phase of HIV Life Cycle;HDR through MMEJ (alt-NHEJ)	PE1	11
+NX_P39877	Calcium-dependent phospholipase A2	138	15674	8.79	0	Secreted	Fleck retina, familial benign	PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.	This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.	Belongs to the phospholipase A2 family.	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI	PE1	1
+NX_P39880	Homeobox protein cut-like 1	1505	164187	5.72	0	Nucleus	Global developmental delay with or without impaired intellectual development	Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.	NA	Belongs to the CUT homeobox family.	Signaling by FGFR1 in disease;Signaling by cytosolic FGFR1 fusion mutants	PE1	7
+NX_P39900	Macrophage metalloelastase	470	54002	8.75	0	Extracellular matrix	NA	May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.	NA	Belongs to the peptidase M10A family.	Degradation of the extracellular matrix;Collagen degradation	PE1	11
+NX_P39905	Glial cell line-derived neurotrophic factor	211	23720	9.26	0	Nucleoplasm;Secreted;Cytoplasmic vesicle	Hirschsprung disease 3;Congenital central hypoventilation syndrome;Pheochromocytoma	Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.	NA	Belongs to the TGF-beta family. GDNF subfamily.	RAF/MAP kinase cascade;NCAM1 interactions;RET signaling	PE1	5
+NX_P40121	Macrophage-capping protein	348	38499	5.82	0	Cytoplasm;Nucleoplasm;Lamellipodium;Melanosome;Ruffle;Nucleus	NA	Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.	The N-terminus is blocked.	Belongs to the villin/gelsolin family.	NA	PE1	2
+NX_P40123	Adenylyl cyclase-associated protein 2	477	52824	5.95	0	Nucleoplasm;Cytosol;Cell membrane	NA	May have a regulatory bifunctional role.	NA	Belongs to the CAP family.	Role of ABL in ROBO-SLIT signaling	PE1	6
+NX_P40126	L-dopachrome tautomerase	519	59145	6.73	1	Cytoplasmic vesicle;Melanosome;Melanosome membrane;Cell membrane	NA	Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels.	Glycosylated.	Belongs to the tyrosinase family.	Pigment biosynthesis; melanin biosynthesis.;Tyrosine metabolism;Metabolic pathways;Melanogenesis;Melanin biosynthesis	PE1	13
+NX_P40145	Adenylate cyclase type 8	1251	140122	6.53	12	Presynaptic cell membrane;Cell membrane;Basolateral cell membrane;Coated pit;Caveola;Postsynaptic density;Synapse;Clathrin-coated vesicle membrane;Dendrite;Apical cell membrane;Axon;Membrane raft	NA	Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.	Phosphorylated by PKA; mediates inhibition of adenylate cyclase activity at membrane raft; does not influence either CALM1 or PPP2CA interaction with ADCY8.;N-glycosylated; N-glycosylation is responsible for raft-targeting; is not necessary for CCE-stimulated adenylate cyclase activity.	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Calcium signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Taste transduction;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;HTLV-I infection;Dilated cardiomyopathy;G alpha (i) signalling events;G alpha (s) signalling events;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G alpha (z) signalling events;CREB1 phosphorylation through the activation of Adenylate Cyclase;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway	PE1	8
+NX_P40189	Interleukin-6 receptor subunit beta	918	103537	5.62	1	Golgi apparatus;Secreted;Cell membrane	NA	Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).	Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009).;Phosphorylation of Ser-782 down-regulates cell surface expression.	Belongs to the type I cytokine receptor family. Type 2 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;MAPK3 (ERK1) activation;Interleukin-6 signaling;MAPK1 (ERK2) activation;IL-6-type cytokine receptor ligand interactions;Interleukin-35 Signalling;Interleukin-27 signaling	PE1	5
+NX_P40197	Platelet glycoprotein V	560	60959	9.73	1	Membrane;Cytosol	NA	The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.	The N-terminus is blocked.	NA	ECM-receptor interaction;Hematopoietic cell lineage;Platelet Adhesion to exposed collagen;Intrinsic Pathway of Fibrin Clot Formation;GP1b-IX-V activation signalling;Platelet Aggregation (Plug Formation)	PE1	3
+NX_P40198	Carcinoembryonic antigen-related cell adhesion molecule 3	252	27091	6.15	1	Membrane	NA	Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.	Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall;Neutrophil degranulation	PE1	19
+NX_P40199	Carcinoembryonic antigen-related cell adhesion molecule 6	344	37195	5.56	0	Cell surface;Apical cell membrane;Cell membrane	NA	Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575).	Glycosylated.	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall;Fibronectin matrix formation;Neutrophil degranulation	PE1	19
+NX_P40200	T-cell surface protein tactile	585	65634	6.71	1	Membrane	C syndrome	May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	3
+NX_P40205	N-cym protein	109	11733	9.03	0	Cytoplasm;Nucleus	NA	Regulates stability of MYCN in neuroblastoma cells by inhibiting GSK3B-mediated MYCN phosphorylation. Inhibits GSK3B activity by promoting its phosphorylation at 'Ser-9' (PubMed:24391509).	NA	NA	NA	PE1	2
+NX_P40222	Alpha-taxilin	546	61891	6.15	0	Nucleoplasm;Cytoplasm;Cytosol;Centrosome	NA	May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.	NA	Belongs to the taxilin family.	Other interleukin signaling	PE1	1
+NX_P40225	Thrombopoietin	353	37823	9.54	0	Secreted	Thrombocythemia 1	Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.	NA	Belongs to the EPO/TPO family.	Hematopoietic cell lineage;Platelet Aggregation (Plug Formation)	PE1	3
+NX_P40227	T-complex protein 1 subunit zeta	531	58024	6.24	0	Cytoplasm	NA	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable).	NA	Belongs to the TCP-1 chaperonin family.	Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	7
+NX_P40238	Thrombopoietin receptor	635	71245	6.03	1	Cell surface;Golgi apparatus;Nucleus membrane;Cell membrane	Thrombocythemia 2;Myelofibrosis with myeloid metaplasia;Congenital amegakaryocytic thrombocytopenia	Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.	Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination.	Belongs to the type I cytokine receptor family. Type 1 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Platelet Aggregation (Plug Formation)	PE1	1
+NX_P40259	B-cell antigen receptor complex-associated protein beta chain	229	26048	5.67	1	Cell membrane	Agammaglobulinemia 6, autosomal recessive	Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.	Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.	NA	B cell receptor signaling pathway;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CD22 mediated BCR regulation	PE1	17
+NX_P40261	Nicotinamide N-methyltransferase	264	29574	5.56	0	Golgi apparatus;Nucleoplasm;Cytosol;Cytoplasm	NA	Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.	Nicotinate and nicotinamide metabolism;Metabolic pathways;Methylation;Nicotinamide salvaging;Metabolism of ingested SeMet, Sec, MeSec into H2Se	PE1	11
+NX_P40305	Interferon alpha-inducible protein 27, mitochondrial	122	11542	11.07	3	Mitochondrion membrane;Nucleus inner membrane;Endosome;Endoplasmic reticulum membrane	NA	Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077).	NA	Belongs to the IFI6/IFI27 family.	Interferon alpha/beta signaling	PE1	14
+NX_P40306	Proteasome subunit beta type-10	273	28936	7.69	0	Cytoplasmic vesicle;Cytosol;Cytoplasm;Nucleus	NA	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.	Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.	Belongs to the peptidase T1B family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	16
+NX_P40313	Chymotrypsin-like protease CTRL-1	264	28002	8.56	0	NA	NA	NA	NA	Belongs to the peptidase S1 family.	Pancreatic secretion;Protein digestion and absorption	PE1	16
+NX_P40337	von Hippel-Lindau disease tumor suppressor	213	24153	4.7	0	Cytoplasm;Membrane;Nucleoplasm;Cytosol;Nucleus	Erythrocytosis, familial, 2;von Hippel-Lindau disease;Pheochromocytoma;Renal cell carcinoma	Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.	NA	Belongs to the VHL family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Pathways in cancer;Renal cell carcinoma;Antigen processing: Ubiquitination &amp; Proteasome degradation;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Neddylation;SUMOylation of ubiquitinylation proteins	PE1	3
+NX_P40394	All-trans-retinol dehydrogenase [NAD(+)] ADH7	386	41481	8.12	0	Cytoplasm;Cytosol;Cell membrane	NA	Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed:15369820, PubMed:16787387, PubMed:9600267). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387, PubMed:15369820). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed:9600267, PubMed:15369820, PubMed:16787387).	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.	Glycolysis / Gluconeogenesis;Fatty acid metabolism;Tyrosine metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Ethanol oxidation	PE1	4
+NX_P40424	Pre-B-cell leukemia transcription factor 1	430	46626	6.54	0	Nucleus	Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay	Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation.;As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity).	NA	Belongs to the TALE/PBX homeobox family.	Transcriptional regulation of pluripotent stem cells;Activation of anterior HOX genes in hindbrain development during early embryogenesis;NOTCH3 Intracellular Domain Regulates Transcription	PE1	1
+NX_P40425	Pre-B-cell leukemia transcription factor 2	430	45881	7.18	0	Nucleoplasm;Nucleus	NA	Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.	NA	Belongs to the TALE/PBX homeobox family.	NA	PE1	6
+NX_P40426	Pre-B-cell leukemia transcription factor 3	434	47190	6.57	0	Cytoplasm;Nucleus	NA	Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.	NA	Belongs to the TALE/PBX homeobox family.	NA	PE1	9
+NX_P40429	60S ribosomal protein L13a	203	23577	10.94	0	Cytoplasm	NA	Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.	Phosphorylation at Ser-77 upon interferon-gamma treatment in monocytes involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.;Citrullinated by PADI4.;RPL13A is phosphorylated by DAPK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the universal ribosomal protein uL13 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_P40616	ADP-ribosylation factor-like protein 1	181	20418	5.63	0	Membrane;Golgi apparatus;trans-Golgi network membrane;Golgi apparatus membrane	NA	GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex (PubMed:9624189, PubMed:21239483, PubMed:27436755, PubMed:22679020, PubMed:27373159). Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells (PubMed:22981988).	NA	Belongs to the small GTPase superfamily. Arf family.	Retrograde transport at the Trans-Golgi-Network	PE1	12
+NX_P40617	ADP-ribosylation factor-like protein 4A	200	22615	9.26	0	Cytoplasm;Cell membrane;Nucleolus;Nucleoplasm;Cytosol	NA	Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.	Myristoylated.	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	7
+NX_P40692	DNA mismatch repair protein Mlh1	756	84601	5.51	0	Nucleoplasm;Nucleus;Chromosome	Endometrial cancer;Colorectal cancer;Hereditary non-polyposis colorectal cancer 2;Muir-Torre syndrome;Mismatch repair cancer syndrome	Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.	NA	Belongs to the DNA mismatch repair MutL/HexB family.	Mismatch repair;Fanconi anemia pathway;Pathways in cancer;Colorectal cancer;Endometrial cancer;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Meiotic recombination;Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);TP53 Regulates Transcription of DNA Repair Genes;Defective Mismatch Repair Associated With MLH1;Defective Mismatch Repair Associated With PMS2	PE1	3
+NX_P40763	Signal transducer and activator of transcription 3	770	88068	5.94	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	Autoimmune disease, multisystem, infantile-onset, 1;Hyper-IgE recurrent infection syndrome 1, autosomal dominant	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).	Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).;Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).;(Microbial infection) Phosphorylated on Tyr-705 in the presence of S.typhimurium SarA.;Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha, LEP and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphorylation at Tyr-705 by PTK6 or FER leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling.;STAT3 is phosphorylated by IGF1R (Phosphotyrosine:PTM-0255);STAT3 is phosphorylated by BMX (Phosphotyrosine:PTM-0255)	Belongs to the transcription factor STAT family.	Chemokine signaling pathway;Jak-STAT signaling pathway;Adipocytokine signaling pathway;Toxoplasmosis;Hepatitis C;Measles;Pathways in cancer;Pancreatic cancer;Acute myeloid leukemia;Transcriptional regulation of pluripotent stem cells;Interleukin-7 signaling;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;Senescence-Associated Secretory Phenotype (SASP);Association of TriC/CCT with target proteins during biosynthesis;Growth hormone receptor signaling;Signaling by SCF-KIT;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Signaling by cytosolic FGFR1 fusion mutants;Interleukin-6 signaling;Signaling by Leptin;Downstream signal transduction;Signalling to STAT3;Interleukin-20 family signaling;PTK6 Activates STAT3;MET activates STAT3;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Interleukin-15 signaling;Interleukin-35 Signalling;Interleukin-9 signaling;Interleukin-37 signaling;Interleukin-23 signaling;Interleukin-21 signaling;Interleukin-27 signaling;Transcriptional regulation of granulopoiesis	PE1	17
+NX_P40818	Ubiquitin carboxyl-terminal hydrolase 8	1118	127523	8.7	0	Cytoplasm;Golgi apparatus;Cell membrane;Endosome membrane;Cytosol;Nucleus	Pituitary adenoma 4, ACTH-secreting	Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062).	Phosphorylation of Ser-718 is essential for interaction with YWHAE and for cytosol localization. Undergoes dephosphorylation at Ser-718 in the M phase. Tyrosine-phosphorylated in its N-terminal half in an EGFR-dependent manner.;Ubiquitinated. Inactive form is mostly monoubiquitinated, but polyubiquitination happens too. Ubiquitination is increased in EGF-stimulated cells. Ubiquitination of active form is undetectable, suggesting a possibility that USP8 deubiquitinates itself, thereby regulating its own function (By similarity).	Belongs to the peptidase C19 family.	Endocytosis;Regulation of FZD by ubiquitination;Downregulation of ERBB2:ERBB3 signaling;Ub-specific processing proteases;Negative regulation of MET activity	PE1	15
+NX_P40855	Peroxisomal biogenesis factor 19	299	32807	4.26	0	Peroxisome membrane;Cytoplasm;Peroxisome	Peroxisome biogenesis disorder complementation group 14;Peroxisome biogenesis disorder 12A	Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.	NA	Belongs to the peroxin-19 family.	Peroxisome;ABC transporters in lipid homeostasis;Class I peroxisomal membrane protein import	PE1	1
+NX_P40879	Chloride anion exchanger	764	84505	8.87	10	Membrane;Apical cell membrane	Diarrhea 1, secretory chloride, congenital	Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.	N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Pancreatic secretion;Mineral absorption;Multifunctional anion exchangers;Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)	PE1	7
+NX_P40925	Malate dehydrogenase, cytoplasmic	334	36426	6.91	0	Cytoplasm;Cytosol;Centrosome	NA	NA	Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation.;ISGylated.	Belongs to the LDH/MDH superfamily. MDH type 2 family.	Citrate cycle (TCA cycle);Pyruvate metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Proximal tubule bicarbonate reclamation;Gluconeogenesis	PE1	2
+NX_P40926	Malate dehydrogenase, mitochondrial	338	35503	8.92	0	Mitochondrion matrix;Mitochondrion	Epileptic encephalopathy, early infantile, 51	NA	Acetylation is enhanced by up to 67% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with the appearance of tri- and tetraacetylations. Glucose also increases acetylation by about 60%.;MDH2 is phosphorylated by MAPK3	Belongs to the LDH/MDH superfamily. MDH type 1 family.	Citrate cycle (TCA cycle);Pyruvate metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Citric acid cycle (TCA cycle);Gluconeogenesis	PE1	7
+NX_P40933	Interleukin-15	162	18086	5.13	0	Cytoplasm;Nucleus speckle;Secreted;Nucleoplasm;Nucleus	NA	Cytokine that stimulates the proliferation of T-lymphocytes (PubMed:8178155). Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (PubMed:8178155). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (PubMed:15123770).	NA	Belongs to the IL-15/IL-21 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Intestinal immune network for IgA production;HTLV-I infection;Herpes simplex infection;Rheumatoid arthritis;Interleukin-15 signaling	PE1	4
+NX_P40937	Replication factor C subunit 5	340	38497	6.72	0	Nucleoplasm;Nucleus	NA	The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	NA	Belongs to the activator 1 small subunits family.	DNA replication;Nucleotide excision repair;Mismatch repair;Translesion Synthesis by POLH;Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Polymerase switching on the C-strand of the telomere;Polymerase switching;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Regulation of TP53 Activity through Phosphorylation	PE1	12
+NX_P40938	Replication factor C subunit 3	356	40556	8.66	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.	NA	Belongs to the activator 1 small subunits family.	DNA replication;Nucleotide excision repair;Mismatch repair;Translesion Synthesis by POLH;Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Polymerase switching on the C-strand of the telomere;Polymerase switching;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Regulation of TP53 Activity through Phosphorylation	PE1	13
+NX_P40939	Trifunctional enzyme subunit alpha, mitochondrial	763	83000	9.16	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial trifunctional protein deficiency;Long-chain 3-hydroxyl-CoA dehydrogenase deficiency;Maternal acute fatty liver of pregnancy	Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:8135828, PubMed:1550553, PubMed:29915090, PubMed:30850536). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity (PubMed:8135828, PubMed:29915090, PubMed:30850536). Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity (PubMed:23152787). It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP (PubMed:23152787). Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity (PubMed:23152787).	NA	In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.;In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid elongation;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Lysine degradation;Tryptophan metabolism;beta-Alanine metabolism;Propanoate metabolism;Butanoate metabolism;Biosynthesis of unsaturated fatty acids;Metabolic pathways;mitochondrial fatty acid beta-oxidation of unsaturated fatty acids;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA;Beta oxidation of hexanoyl-CoA to butanoyl-CoA;Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA;Beta oxidation of palmitoyl-CoA to myristoyl-CoA;Acyl chain remodeling of CL;Beta oxidation of myristoyl-CoA to lauroyl-CoA	PE1	2
+NX_P40967	Melanocyte protein PMEL	661	70255	5.37	1	Golgi apparatus;Endoplasmic reticulum membrane;Secreted;Endoplasmic reticulum;Melanosome;Multivesicular body	NA	Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.	N-glycosylated. O-glycosylated; contains sialic acid.;A small amount of P1/P100 (major form) undergoes glycosylation to yield P2/P120 (minor form). P2 is cleaved by a furin-like proprotein convertase (PC) in a pH-dependent manner in a post-Golgi, prelysosomal compartment into two disulfide-linked subunits: a large lumenal subunit, M-alpha/ME20-S, and an integral membrane subunit, M-beta. Despite cleavage, only a small fraction of M-alpha is secreted, whereas most M-alpha and M-beta remain associated with each other intracellularly. M-alpha is further processed to M-alpha N and M-alpha C. M-alpha C further undergoes processing to yield M-alpha C1 and M-alpha C3 (M-alpha C2 in the case of PMEL17-is or PMEL17-ls). Formation of intralumenal fibrils in the melanosomes requires the formation of M-alpha that becomes incorporated into the fibrils. Stage II melanosomes harbor only Golgi-modified Pmel17 fragments that are derived from M-alpha and that bear sialylated O-linked oligosaccharides.	Belongs to the PMEL/NMB family.	NA	PE1	12
+NX_P41002	Cyclin-F	786	87640	5.92	0	Centrosome;Nucleus;Centriole	NA	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.	Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence.;Phosphorylated just before cells enter into mitosis.	Belongs to the cyclin family. Cyclin AB subfamily.	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	16
+NX_P41091	Eukaryotic translation initiation factor 2 subunit 3	472	51109	8.66	0	NA	MEHMO syndrome	As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.	RNA transport;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP;ABC-family proteins mediated transport;PERK regulates gene expression	PE1	X
+NX_P41134	DNA-binding protein inhibitor ID-1	155	16133	6.57	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).	NA	NA	TGF-beta signaling pathway;Oncogene Induced Senescence	PE1	20
+NX_P41143	Delta-type opioid receptor	372	40369	9.21	7	Cell membrane	NA	G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.	N-glycosylated.;Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors;Interleukin-4 and Interleukin-13 signaling	PE1	1
+NX_P41145	Kappa-type opioid receptor	380	42645	7.92	7	Nucleoplasm;Cytosol;Cell membrane	NA	G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors;MECP2 regulates neuronal receptors and channels	PE1	8
+NX_P41146	Nociceptin receptor	370	40693	8.74	7	Cytoplasmic vesicle;Cell membrane	NA	G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.	Phosphorylation at Ser-363 requires GRK3.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	20
+NX_P41159	Leptin	167	18641	5.88	0	Secreted	Leptin deficiency	Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:8589726, PubMed:11460888, PubMed:19688109, PubMed:24340098, PubMed:25060689). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (PubMed:24340098). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (PubMed:12504075). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (PubMed:15899045, PubMed:19688109). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (PubMed:25060689).	NA	Belongs to the leptin family.	Cytokine-cytokine receptor interaction;Neuroactive ligand-receptor interaction;Jak-STAT signaling pathway;Adipocytokine signaling pathway;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Transcriptional regulation of white adipocyte differentiation;Synthesis, secretion, and deacylation of Ghrelin;Signaling by Leptin	PE1	7
+NX_P41161	ETS translocation variant 5	510	57838	5.43	0	Nucleoplasm;Nucleus	NA	Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.	NA	Belongs to the ETS family.	NA	PE1	3
+NX_P41162	ETS translocation variant 3	512	57001	8.73	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.	NA	Belongs to the ETS family.	NA	PE1	1
+NX_P41180	Extracellular calcium-sensing receptor	1078	120675	5.62	7	Cell membrane	Epilepsy, idiopathic generalized 8;Hypocalciuric hypercalcemia, familial 1;Hyperparathyroidism, neonatal severe;Hypocalcemia, autosomal dominant 1	G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).	N-glycosylated.;Ubiquitinated by RNF19A; which induces proteasomal degradation.	Belongs to the G-protein coupled receptor 3 family.	G alpha (i) signalling events;G alpha (q) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	3
+NX_P41181	Aquaporin-2	271	28837	6.44	6	Cell membrane;Basolateral cell membrane;trans-Golgi network membrane;Cytoplasmic vesicle membrane;Apical cell membrane	Diabetes insipidus, nephrogenic, autosomal	Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:8140421, PubMed:7524315, PubMed:7510718, PubMed:15509592). Plays an essential role in renal water homeostasis (PubMed:8140421, PubMed:7524315, PubMed:15509592).	N-glycosylated.;Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.	Belongs to the MIP/aquaporin (TC 1.A.8) family.	Vasopressin-regulated water reabsorption;Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins	PE1	12
+NX_P41182	B-cell lymphoma 6 protein	706	78846	8.28	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.	Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.;Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.;Polyubiquitinated (PubMed:9649500, PubMed:22113614, PubMed:30190310). Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome (PubMed:22113614). Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteaseome: ubiquitination by the SCF(FBXL17) complex takes place when aberrant BTB domain dimers are formed (PubMed:30190310).	NA	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Interleukin-4 and Interleukin-13 signaling;FOXO-mediated transcription of cell death genes	PE1	3
+NX_P41208	Centrin-2	172	19738	4.91	0	Cytoplasm;Nuclear pore complex;Centriole;Nucleus envelope;Centrosome;Nucleus	NA	Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.;Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.;As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.;The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.	NA	Belongs to the centrin family.	Nucleotide excision repair;SUMOylation of DNA damage response and repair proteins;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;AURKA Activation by TPX2	PE1	X
+NX_P41212	Transcription factor ETV6	452	53000	6.95	0	Nucleolus;Nucleus;Cytosol	Myeloproliferative disorder chronic with eosinophilia;Leukemia, acute myelogenous;Thrombocytopenia 5	Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.	Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression.	Belongs to the ETS family.	Dorso-ventral axis formation	PE1	12
+NX_P41214	Eukaryotic translation initiation factor 2D	584	64706	7.56	0	Cytoplasm;Cytosol;Nucleus	NA	Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.	NA	Belongs to the eIF2D family.	NA	PE1	1
+NX_P41217	OX-2 membrane glycoprotein	278	31264	8.78	1	Cell membrane	NA	Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	3
+NX_P41218	Myeloid cell nuclear differentiation antigen	407	45836	9.76	0	Nucleoplasm;Cytoplasm;Nucleolus;Nucleus	NA	May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.	NA	NA	Neutrophil degranulation	PE1	1
+NX_P41219	Peripherin	470	53651	5.37	0	NA	NA	Class-III neuronal intermediate filament protein.	NA	Belongs to the intermediate filament family.	Amyotrophic lateral sclerosis (ALS)	PE1	12
+NX_P41220	Regulator of G-protein signaling 2	211	24382	9.05	0	Cytoplasm;Mitochondrion;Cell membrane;Nucleolus;Cytosol	NA	Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).	Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.	NA	G alpha (q) signalling events	PE1	1
+NX_P41221	Protein Wnt-5a	380	42339	8.83	0	Extracellular matrix;Secreted	Robinow syndrome, autosomal dominant 1	Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity).	Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.;Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.;Glycosylation is necessary for secretion but not for activity.	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Asymmetric localization of PCP proteins;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors);TCF dependent signaling in response to WNT;PCP/CE pathway;Ca2+ pathway;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	3
+NX_P41222	Prostaglandin-H2 D-isomerase	190	21029	7.66	0	Golgi apparatus;Secreted;Nucleus membrane;Rough endoplasmic reticulum;Perinuclear region	NA	Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.	N- and O-glycosylated. Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. N-glycan at Asn-78: dHex1Hex5HexNAc4. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing alpha2-3- and/or alpha2-6-linked NeuNAc are present.	Belongs to the calycin superfamily. Lipocalin family.	Arachidonic acid metabolism;Metabolic pathways;Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	PE1	9
+NX_P41223	Protein BUD31 homolog	144	17000	9.1	0	Nucleoplasm;Centrosome;Nucleus;Cytoskeleton	NA	Involved in the pre-mRNA splicing process (PubMed:28502770, PubMed:28076346). May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity (PubMed:25091737).	NA	Belongs to the BUD31 (G10) family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	7
+NX_P41225	Transcription factor SOX-3	446	45210	9.78	0	Nucleoplasm;Nucleus	Panhypopituitarism X-linked;Hypoparathyroidism, X-linked;46,XX sex reversal 3;Mental retardation, X-linked, with isolated growth hormone deficiency	Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity).	NA	NA	Deactivation of the beta-catenin transactivating complex	PE1	X
+NX_P41226	Ubiquitin-like modifier-activating enzyme 7	1012	111694	5.64	0	Nucleoplasm;Cytosol;Cytoplasmic vesicle	NA	Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.	ISGylated.	Belongs to the ubiquitin-activating E1 family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Parkinson's disease;Antigen processing: Ubiquitination &amp; Proteasome degradation;ISG15 antiviral mechanism;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;Termination of translesion DNA synthesis	PE1	3
+NX_P41227	N-alpha-acetyltransferase 10	235	26459	5.41	0	Nucleolus;Cytoplasm;Cytosol;Nucleus	N-terminal acetyltransferase deficiency;Microphthalmia, syndromic, 1	Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821).	Cleaved by caspases during apoptosis.;Autoacetylated at Lys-136 which stimulates its catalytic activity.;Phosphorylation by IKBKB/IKKB at Ser-209 promotes its proteasome-mediated degradation.	Belongs to the acetyltransferase family. ARD1 subfamily.	NA	PE1	X
+NX_P41229	Lysine-specific demethylase 5C	1560	175720	5.44	0	Nucleoplasm;Cytosol;Nucleus	Mental retardation, X-linked, syndromic, Claes-Jensen type	Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).	NA	Belongs to the JARID1 histone demethylase family.	HDMs demethylate histones	PE1	X
+NX_P41231	P2Y purinoceptor 2	377	42273	9.72	7	Cytosol;Cell membrane	NA	Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;P2Y receptors;Surfactant metabolism	PE1	11
+NX_P41235	Hepatocyte nuclear factor 4-alpha	474	52785	7.15	0	Nucleoplasm;Nucleus	Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young;Maturity-onset diabetes of the young 1;Diabetes mellitus, non-insulin-dependent	Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698).	Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA.;Acetylation at Lys-458 lowers transcriptional activation by about two-fold.	Belongs to the nuclear hormone receptor family. NR2 subfamily.	Maturity onset diabetes of the young;Regulation of gene expression in beta cells;Nuclear Receptor transcription pathway	PE1	20
+NX_P41236	Protein phosphatase inhibitor 2	205	23015	4.64	0	Cytoplasm;Nucleus	NA	Inhibitor of protein-phosphatase 1.	Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.	Belongs to the protein phosphatase inhibitor 2 family.	NA	PE1	3
+NX_P41238	C->U-editing enzyme APOBEC-1	236	28192	9.06	0	Cytoplasm	NA	Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	mRNA Editing: C to U Conversion;Formation of the Editosome	PE1	12
+NX_P41240	Tyrosine-protein kinase CSK	450	50704	6.62	0	Cytoplasmic vesicle;Cytoplasm;Cytosol;Cell membrane	NA	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.	Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.	Epithelial cell signaling in Helicobacter pylori infection;Phosphorylation of CD3 and TCR zeta chains;PD-1 signaling;MAP2K and MAPK activation;Integrin alphaIIb beta3 signaling;GAB1 signalosome;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	15
+NX_P41247	Patatin-like phospholipase domain-containing protein 4	253	27980	9.21	0	Mitochondrion	NA	Lipid hydrolase.	NA	NA	Retinol metabolism;Triglyceride catabolism	PE1	X
+NX_P41250	Glycine--tRNA ligase	739	83166	6.61	0	Extracellular exosome;Cytoplasm;Secreted;Cytosol;Axon	Charcot-Marie-Tooth disease 2D;Neuronopathy, distal hereditary motor, 5A	Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:28675565, PubMed:24898252). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017).	NA	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation;Cytosolic tRNA aminoacylation	PE1	7
+NX_P41252	Isoleucine--tRNA ligase, cytoplasmic	1262	144498	5.82	0	Cytoplasm;Cytosol	Growth retardation, impaired intellectual development, hypotonia, and hepatopathy	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation;Selenoamino acid metabolism	PE1	9
+NX_P41271	Neuroblastoma suppressor of tumorigenicity 1	181	19408	5.15	0	Secreted	NA	Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.	NA	Belongs to the DAN family.	NA	PE1	1
+NX_P41273	Tumor necrosis factor ligand superfamily member 9	254	26625	6.52	1	Membrane;Golgi apparatus	NA	Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.	NA	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	19
+NX_P41279	Mitogen-activated protein kinase kinase kinase 8	467	52925	5.54	0	Cytoplasm;Cytosol	NA	Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle.;Shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.	Autophosphorylated (PubMed:8226782, PubMed:1833717).;Undergoes phosphorylation mainly on Ser residues, and isoform 2 on both Ser and Thr residues (PubMed:8226782). Phosphorylated on Thr-290; the phosphorylation is necessary but not sufficient for full kinase activity in vitro and for the dissociation of isoform 1 from NFKB1, leading to its degradation (PubMed:15466476, PubMed:15699325). Phosphorylated on Ser-400 by IKBKB; the phosphorylation is required for LPS-stimulated activation of the MAPK/ERK pathway in macrophages (PubMed:17472361, PubMed:22988300).	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway;Toll-like receptor signaling pathway;T cell receptor signaling pathway;CD28 dependent PI3K/Akt signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation	PE1	10
+NX_P41439	Folate receptor gamma	245	27885	7.86	0	Secreted	NA	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.	NA	Belongs to the folate receptor family.	Endocytosis;Neutrophil degranulation	PE1	11
+NX_P41440	Reduced folate transporter	591	64868	9.15	12	Basolateral cell membrane;Apical cell membrane;Cell membrane	NA	Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides (PubMed:7826387, PubMed:9041240, PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:31126740). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803). Also able to mediate the import of antifolate drug methotrexate (PubMed:7615551, PubMed:7641195, PubMed:9767079, PubMed:22554803). Acts as an importer of cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP (PubMed:31126740). Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates (PubMed:22554803). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803).	NA	Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.	Vitamin digestion and absorption;Metabolism of folate and pterines	PE1	21
+NX_P41567	Eukaryotic translation initiation factor 1	113	12732	6.9	0	NA	NA	Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.	NA	Belongs to the SUI1 family.	RNA transport	PE1	17
+NX_P41586	Pituitary adenylate cyclase-activating polypeptide type I receptor	468	53314	5.5	7	Cytoplasmic vesicle;Cell membrane	NA	This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.	NA	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Glucagon-type ligand receptors;NGF-independant TRKA activation	PE1	7
+NX_P41587	Vasoactive intestinal polypeptide receptor 2	438	49479	8.29	7	Focal adhesion;Cell membrane	NA	This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.	NA	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Glucagon-type ligand receptors	PE1	7
+NX_P41594	Metabotropic glutamate receptor 5	1212	132469	8.07	7	Cell membrane	NA	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.	NA	Belongs to the G-protein coupled receptor 3 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Gap junction;Long-term potentiation;Glutamatergic synapse;Long-term depression;Huntington's disease;G alpha (q) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors);Neurexins and neuroligins	PE1	11
+NX_P41595	5-hydroxytryptamine receptor 2B	481	54298	9.22	7	Nucleoplasm;Cell membrane;Synaptosome	NA	G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538). Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Gap junction;G alpha (q) signalling events;Serotonin receptors	PE1	2
+NX_P41597	C-C chemokine receptor type 2	374	41915	9.24	7	Cell membrane	NA	(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.;Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (PubMed:8146186, PubMed:8048929, PubMed:23408426). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity).	Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form (PubMed:11046064, PubMed:23408426). Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer (PubMed:11046064, PubMed:23408426).;N-glycosylated.	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines;Beta defensins;Interleukin-10 signaling	PE1	3
+NX_P41732	Tetraspanin-7	249	27574	6.86	4	Membrane	Mental retardation, X-linked 58	May be involved in cell proliferation and cell motility.	NA	Belongs to the tetraspanin (TM4SF) family.	Cell surface interactions at the vascular wall;Trafficking of GluR2-containing AMPA receptors	PE1	X
+NX_P41743	Protein kinase C iota type	596	68262	5.54	0	Cytoplasm;Membrane;Endosome;Cytosol;Nucleus;Cytoskeleton	NA	Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity).	Phosphorylation at Thr-412 in the activation loop is not mandatory for activation (By similarity). Upon neuronal growth factor (NGF) stimulation, phosphorylated by SRC at Tyr-265, Tyr-280 and Tyr-334 (PubMed:11713277, PubMed:16452474). Phosphorylation at Tyr-265 facilitates binding to KPNB1/importin-beta regulating entry of PRKCI into the nucleus (PubMed:11891849). Phosphorylation on Tyr-334 is important for NF-kappa-B stimulation (PubMed:11713277). Phosphorylated at Thr-564 during the initial phase of long term potentiation (By similarity).	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Endocytosis;Tight junction;Insulin signaling pathway;Tight junction interactions;p75NTR recruits signalling complexes;Pre-NOTCH Transcription and Translation	PE1	3
+NX_P41968	Melanocortin receptor 3	323	36043	6.34	7	Cell membrane	NA	Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (s) signalling events	PE1	20
+NX_P41970	ETS domain-containing protein Elk-3	407	44240	9.04	0	Nucleoplasm;Mitochondrion;Nucleus	NA	May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.	NA	Belongs to the ETS family.	NA	PE1	12
+NX_P42025	Beta-centractin	376	42293	5.98	0	Cytoplasm;Centrosome;Cytoskeleton	NA	Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.	NA	Belongs to the actin family. ARP1 subfamily.	MHC class II antigen presentation;Neutrophil degranulation	PE1	2
+NX_P42081	T-lymphocyte activation antigen CD86	329	37682	6.46	1	Cell membrane	NA	(Microbial infection) Acts as a receptor for adenovirus subgroup B.;Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation.;Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.	Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.	NA	Cell adhesion molecules (CAMs);Toll-like receptor signaling pathway;Intestinal immune network for IgA production;Type I diabetes mellitus;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;CD28 dependent PI3K/Akt signaling;CD28 co-stimulation;CD28 dependent Vav1 pathway;CTLA4 inhibitory signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-10 signaling	PE1	3
+NX_P42126	Enoyl-CoA delta isomerase 1, mitochondrial	302	32816	8.8	0	Mitochondrion matrix;Mitochondrion	NA	Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.	NA	Belongs to the enoyl-CoA hydratase/isomerase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid metabolism;mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	PE1	16
+NX_P42127	Agouti-signaling protein	132	14515	9.78	0	Cytoplasmic vesicle;Secreted	NA	Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.	NA	NA	Melanogenesis	PE1	20
+NX_P42166	Lamina-associated polypeptide 2, isoform alpha	694	75492	7.56	0	Nucleus;Nucleus membrane;Chromosome	NA	TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.;May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.	Phosphorylated in a mitose-specific manner.	Belongs to the LEM family.	NA	PE1	12
+NX_P42167	Lamina-associated polypeptide 2, isoforms beta/gamma	454	50670	9.39	1	Cytoplasm;Nucleus inner membrane	NA	Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.;May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.	Citrullinated by PADI4.;Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes.	Belongs to the LEM family.	Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina;Nuclear Envelope Breakdown	PE1	12
+NX_P42224	Signal transducer and activator of transcription 1-alpha/beta	750	87335	5.74	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Immunodeficiency 31C;Immunodeficiency 31A;Immunodeficiency 31B	Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.	ISGylated.;Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727, and by interaction with PIAS proteins. Enhances the transactivation activity.;Mono-ADP-ribosylated at Glu-657 and Glu-705 by PARP14; ADP-ribosylation prevents phosphorylation at Tyr-701 (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of phosphorylation has been called into question and the lack of phosphorylation may be due to sumoylation of Lys-703 (PubMed:29858569).;Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including IFN-alpha, IFN-gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1, JAK2 or TYK2 promotes dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates STAT1 signaling only via JAK2. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMKII on IFN-gamma stimulation, regulates STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though increasing interaction with PIAS. Phosphorylation on Ser-727 by PRKCD induces apoptosis in response to DNA-damaging agents. Phosphorylated on tyrosine residues when PTK2/FAK1 is activated; most likely this is catalyzed by a SRC family kinase. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates interferon-mediated signaling. Upon viral infection or IFN induction, phosphorylation on Ser-708 occurs much later than phosphorylation on Tyr-701 and is required for the binding of ISGF3 on the ISREs of a subset of IFN-stimulated genes IKBKE-dependent. Phosphorylation at Tyr-701 and Ser-708 are mutually exclusive, phosphorylation at Ser-708 requires previous dephosphorylation of Tyr-701.;Monomethylated at Lys-525 by SETD2; monomethylation is necessary for phosphorylation at Tyr-701, translocation into the nucleus and activation of the antiviral defense.;STAT1 is phosphorylated by BMX (Phosphotyrosine:PTM-0255);STAT1 is phosphorylated by FGFR4	Belongs to the transcription factor STAT family.	Chemokine signaling pathway;Osteoclast differentiation;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Leishmaniasis;Toxoplasmosis;Tuberculosis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Pathways in cancer;Pancreatic cancer;ISG15 antiviral mechanism;Interferon gamma signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling;Growth hormone receptor signaling;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Regulation of IFNG signaling;Interleukin-6 signaling;Downstream signal transduction;Interleukin-20 family signaling;Interleukin-4 and Interleukin-13 signaling;Regulation of RUNX2 expression and activity;Interleukin-35 Signalling;Interleukin-9 signaling;NOTCH3 Intracellular Domain Regulates Transcription;Interleukin-21 signaling;Interleukin-27 signaling	PE1	2
+NX_P42226	Signal transducer and activator of transcription 6	847	94135	5.84	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.	Mono-ADP-ribosylated by PARP14.;Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).	Belongs to the transcription factor STAT family.	Jak-STAT signaling pathway;STAT6-mediated induction of chemokines;Downstream signal transduction;Interleukin-4 and Interleukin-13 signaling	PE1	12
+NX_P42229	Signal transducer and activator of transcription 5A	794	90647	5.98	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.	ISGylated.;Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (PubMed:21135090). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3 (PubMed:14504097). Alternatively, can be phosphorylated by JAK2 at Tyr-694 (PubMed:12529425).;STAT5A is phosphorylated by FLT3;STAT5A is phosphorylated by BMX (Phosphotyrosine:PTM-0255)	Belongs to the transcription factor STAT family.	ErbB signaling pathway;Jak-STAT signaling pathway;Measles;HTLV-I infection;Pathways in cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Interleukin-7 signaling;Nuclear signaling by ERBB4;Prolactin receptor signaling;Growth hormone receptor signaling;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Interleukin-3, Interleukin-5 and GM-CSF signaling;Signaling by Leptin;Downstream signal transduction;Interleukin-20 family signaling;Interleukin-15 signaling;Interleukin-9 signaling;Interleukin-2 signaling;Interleukin-21 signaling;Erythropoietin activates STAT5;STAT5 Activation	PE1	17
+NX_P42261	Glutamate receptor 1	906	101506	7.79	3	Dendritic spine;Endoplasmic reticulum membrane;Cell membrane;Postsynaptic cell membrane;Recycling endosome membrane;Postsynaptic density membrane;Early endosome membrane;Dendrite	NA	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).;Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2 (By similarity). Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (By similarity).	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.	Neuroactive ligand-receptor interaction;Long-term potentiation;Glutamatergic synapse;Dopaminergic synapse;Long-term depression;Amyotrophic lateral sclerosis (ALS);Unblocking of NMDA receptors, glutamate binding and activation;Trafficking of AMPA receptors;COPII-mediated vesicle transport;Trafficking of GluR2-containing AMPA receptors;Activation of AMPA receptors;Cargo concentration in the ER;Synaptic adhesion-like molecules;Long-term potentiation	PE1	5
+NX_P42262	Glutamate receptor 2	883	98821	7.48	3	Postsynaptic cell membrane;Endoplasmic reticulum membrane;Cell membrane	NA	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.	Neuroactive ligand-receptor interaction;Long-term potentiation;Glutamatergic synapse;Dopaminergic synapse;Long-term depression;Amyotrophic lateral sclerosis (ALS);Unblocking of NMDA receptors, glutamate binding and activation;Trafficking of GluR2-containing AMPA receptors;Activation of AMPA receptors;MECP2 regulates neuronal receptors and channels;Long-term potentiation	PE1	4
+NX_P42263	Glutamate receptor 3	894	101157	8.72	3	Postsynaptic cell membrane;Cell membrane	Mental retardation, X-linked 94	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.	Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;Dopaminergic synapse;Long-term depression;Unblocking of NMDA receptors, glutamate binding and activation;Trafficking of AMPA receptors;Trafficking of GluR2-containing AMPA receptors;Activation of AMPA receptors;Synaptic adhesion-like molecules	PE1	X
+NX_P42285	Exosome RNA helicase MTR4	1042	117805	6.12	0	Nucleoplasm;Nucleolus;Nucleus speckle;Nucleus	NA	Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing.	NA	Belongs to the helicase family. SKI2 subfamily.	RNA degradation;mRNA Splicing - Major Pathway;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	5
+NX_P42330	Aldo-keto reductase family 1 member C3	323	36853	8.06	0	Cytoplasm;Nucleus	NA	Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.	NA	Belongs to the aldo/keto reductase family.	Steroid hormone biosynthesis;Arachidonic acid metabolism;Metabolism of xenobiotics by cytochrome P450;RA biosynthesis pathway;Retinoid metabolism and transport;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol	PE1	10
+NX_P42331	Rho GTPase-activating protein 25	645	73435	6.04	0	Cytoplasmic vesicle;Nucleoplasm	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	NA	NA	Rho GTPase cycle	PE1	2
+NX_P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	1068	124284	6.88	0	Cytosol	Macrodactyly;Breast cancer;Ovarian cancer;Keratosis, seborrheic;CLAPO syndrome;Colorectal cancer;Megalencephaly-capillary malformation-polymicrogyria syndrome;Cowden syndrome 5;Hepatocellular carcinoma;Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).	NA	Belongs to the PI3/PI4-kinase family.	Inositol phosphate metabolism;ErbB signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;mTOR signaling pathway;Apoptosis;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Cholinergic synapse;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Carbohydrate digestion and absorption;Bacterial invasion of epithelial cells;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Acute myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;G alpha (q) signalling events;Synthesis of PIPs at the plasma membrane;Downstream TCR signaling;PI3K Cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;Role of LAT2/NTAL/LAB on calcium mobilization;GPVI-mediated activation cascade;Interleukin receptor SHC signaling;DAP12 signaling;VEGFA-VEGFR2 Pathway;CD28 dependent PI3K/Akt signaling;PI3K events in ERBB4 signaling;PI3K events in ERBB2 signaling;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Role of phospholipids in phagocytosis;Interleukin-3, Interleukin-5 and GM-CSF signaling;Nephrin family interactions;Regulation of signaling by CBL;Tie2 Signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Costimulation by the CD28 family;PI3K/AKT activation;Downstream signal transduction;GAB1 signalosome;Constitutive Signaling by EGFRvIII;Signaling by FGFR4 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR3 fusions in cancer;RET signaling;MET activates PI3K/AKT signaling;IRS-mediated signalling;Activated NTRK3 signals through PI3K;Activated NTRK2 signals through PI3K;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Extra-nuclear estrogen signaling	PE1	3
+NX_P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1070	122762	6.69	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytoplasmic vesicle;Nucleus;Midbody	NA	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.	Phosphorylation at Ser-1070 down-regulates lipid kinase activity.	Belongs to the PI3/PI4-kinase family.	Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.;Inositol phosphate metabolism;ErbB signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;mTOR signaling pathway;Apoptosis;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Cholinergic synapse;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Carbohydrate digestion and absorption;Bacterial invasion of epithelial cells;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Acute myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Synthesis of PIPs at the plasma membrane;Downstream TCR signaling;PI3K Cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Role of LAT2/NTAL/LAB on calcium mobilization;GPVI-mediated activation cascade;Interleukin receptor SHC signaling;DAP12 signaling;VEGFA-VEGFR2 Pathway;Role of phospholipids in phagocytosis;Interleukin-3, Interleukin-5 and GM-CSF signaling;Nephrin family interactions;Regulation of signaling by CBL;Tie2 Signaling;PI3K/AKT activation;Downstream signal transduction;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;IRS-mediated signalling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	PE1	3
+NX_P42345	Serine/threonine-protein kinase mTOR	2549	288892	6.73	0	Microsome membrane;Cytoplasm;Mitochondrion outer membrane;Endoplasmic reticulum membrane;Lysosome membrane;PML body;Golgi apparatus membrane;Cytoplasmic vesicle;Cytosol;Lysosome	Smith-Kingsmore syndrome;Focal cortical dysplasia 2	Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18925875, PubMed:18497260, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (By similarity). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12150925, PubMed:12087098, PubMed:18925875). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429704, PubMed:23429703). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (By similarity). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). MTORC1 also negatively regulates autophagy through phosphorylation of ULK1 (By similarity). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (By similarity). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). MTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton (PubMed:15268862, PubMed:15467718). Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1 (PubMed:15718470). MTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). MTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). Phosphorylates SQSTM1, promoting interaction between SQSTM1 and KEAP1 and subsequent inactivation of the BCR(KEAP1) complex (By similarity).	Autophosphorylates when part of mTORC1 or mTORC2. Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes autophosphorylation. Phosphorylation in the kinase domain modulates the interactions of MTOR with RPTOR and PRAS40 and leads to increased intrinsic mTORC1 kinase activity. Phosphorylation at Thr-2173 in the ATP-binding region by AKT1 strongly reduces kinase activity.	Belongs to the PI3/PI4-kinase family.	ErbB signaling pathway;mTOR signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Type II diabetes mellitus;Pathways in cancer;Glioma;Prostate cancer;Acute myeloid leukemia;Macroautophagy;PIP3 activates AKT signaling;VEGFR2 mediated vascular permeability;CD28 dependent PI3K/Akt signaling;HSF1-dependent transactivation;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;Constitutive Signaling by AKT1 E17K in Cancer;mTOR signalling;mTORC1-mediated signalling;Regulation of TP53 Degradation;Regulation of PTEN gene transcription	PE1	1
+NX_P42356	Phosphatidylinositol 4-kinase alpha	2102	236830	6.64	0	Cytoplasm;Cell membrane	Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis	Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.	NA	Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the ER membrane;Synthesis of PIPs at the Golgi membrane	PE1	22
+NX_P42357	Histidine ammonia-lyase	657	72698	6.49	0	Cytosol	Histidinemia	NA	Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.	Belongs to the PAL/histidase family.	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.;Histidine metabolism;Nitrogen metabolism;Metabolic pathways;Histidine catabolism	PE1	12
+NX_P42566	Epidermal growth factor receptor substrate 15	896	98656	4.52	0	Cytoplasm;Cell membrane;Clathrin-coated pit;Early endosome membrane;Cytoplasmic vesicle;Cytosol	NA	Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.	Ubiquitinated.;Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR.	NA	Endocytosis;EGFR downregulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Negative regulation of MET activity;InlB-mediated entry of Listeria monocytogenes into host cell	PE1	1
+NX_P42568	Protein AF-9	568	63351	8.77	0	Nucleoplasm;Cytosol;Nucleus;Chromosome	NA	Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619).	NA	NA	Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation	PE1	9
+NX_P42574	Caspase-3	277	31608	6.09	0	Nucleoplasm;Cytoplasm;Mitochondrion	NA	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.	Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.;S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.	Belongs to the peptidase C14A family.	MAPK signaling pathway;p53 signaling pathway;Apoptosis;Natural killer cell mediated cytotoxicity;Alzheimer's disease;Parkinson's disease;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Epithelial cell signaling in Helicobacter pylori infection;Pertussis;Legionellosis;Toxoplasmosis;Amoebiasis;Tuberculosis;Herpes simplex infection;Pathways in cancer;Colorectal cancer;Viral myocarditis;Degradation of the extracellular matrix;Signaling by Hippo;Caspase-mediated cleavage of cytoskeletal proteins;Apoptotic cleavage of cell adhesion proteins;Caspase activation via Dependence Receptors in the absence of ligand;Apoptotic cleavage of cellular proteins;Activation of caspases through apoptosome-mediated cleavage;NADE modulates death signalling;Stimulation of the cell death response by PAK-2p34;SMAC (DIABLO) binds to IAPs;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes;Other interleukin signaling;Apoptosis induced DNA fragmentation;SMAC, XIAP-regulated apoptotic response	PE1	4
+NX_P42575	Caspase-2	452	50685	6.35	0	Nucleoplasm	NA	Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321).	The mature protease can process its own propeptide, but not that of other caspases.	Belongs to the peptidase C14A family.	NOD1/2 Signaling Pathway;NADE modulates death signalling;TP53 Regulates Transcription of Caspase Activators and Caspases	PE1	7
+NX_P42658	Dipeptidyl aminopeptidase-like protein 6	865	97588	5.95	1	Cell membrane	Familial paroxysmal ventricular fibrillation 2;Mental retardation, autosomal dominant 33	Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821).	N-glycosylated.	Belongs to the peptidase S9B family.	NA	PE1	7
+NX_P42677	40S ribosomal protein S27	84	9461	9.57	0	NA	Diamond-Blackfan anemia 17	Component of the small ribosomal subunit (PubMed:8706699). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902).	NA	Belongs to the eukaryotic ribosomal protein eS27 family.	Ribosome;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	1
+NX_P42679	Megakaryocyte-associated tyrosine-protein kinase	507	56469	9.01	0	Cytoplasm;Centriolar satellite;Membrane;Cytosol;Spindle;Cytoskeleton	NA	Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.	Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.	Neurotrophin signaling pathway;Downregulation of ERBB2 signaling	PE1	19
+NX_P42680	Tyrosine-protein kinase Tec	631	73581	8.69	0	Cytoplasm;Cell membrane;Cytoskeleton	NA	Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.	Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-519. Undergoes also tyrosine phosphorylation during platelet activation.;Autophosphorylated (Phosphotyrosine:PTM-0255);TEC is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.	Osteoclast differentiation;T cell receptor signaling pathway;FCERI mediated Ca+2 mobilization;Signaling by SCF-KIT;Interleukin-3, Interleukin-5 and GM-CSF signaling	PE1	4
+NX_P42681	Tyrosine-protein kinase TXK	527	61258	8.23	0	Cytoplasmic vesicle;Cytoplasm;Nucleus;Cell membrane	NA	Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.	Phosphorylated at Tyr-420 by FYN. Autophosphorylation at Tyr-91 is critical for the activation of TXK, leading to the up-regulation of IFN-gamma gene transcription.;The cysteine string at the N-terminus is palmitoylated and required for the proper subcellular location.;TXK is phosphorylated by LCK (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.	Leukocyte transendothelial migration;FCERI mediated Ca+2 mobilization	PE1	4
+NX_P42684	Tyrosine-protein kinase ABL2	1182	128343	8.31	0	Nucleoplasm;Cytoskeleton	NA	Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.	Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.;Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity).;ABL2 is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255);ABL2 is phosphorylated by PDGFRB (Phosphotyrosine:PTM-0255);ABL2 is phosphorylated by EPHB2 (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.	ErbB signaling pathway;Viral myocarditis;Role of ABL in ROBO-SLIT signaling	PE1	1
+NX_P42685	Tyrosine-protein kinase FRK	505	58254	6.22	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.	Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.	Neutrophil degranulation;Regulation of PTEN stability and activity	PE1	6
+NX_P42694	Probable helicase with zinc finger domain	1942	218970	7.04	0	Nucleolus;Cell membrane;Nucleus;Cytoskeleton	NA	May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.	NA	Belongs to the DNA2/NAM7 helicase family.	NA	PE1	17
+NX_P42695	Condensin-2 complex subunit D3	1498	168891	7.38	0	Nucleoplasm;Nucleus	Microcephaly 22, primary, autosomal recessive	Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).	NA	NA	Condensation of Prophase Chromosomes	PE1	11
+NX_P42696	RNA-binding protein 34	430	48565	10.11	0	Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the RRM RBM34 family.	NA	PE1	1
+NX_P42701	Interleukin-12 receptor subunit beta-1	662	73109	5.28	1	Membrane;Cell membrane	Immunodeficiency 30	Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.	NA	Belongs to the type I cytokine receptor family. Type 2 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-12 signaling;Interleukin-23 signaling	PE1	19
+NX_P42702	Leukemia inhibitory factor receptor	1097	123743	5.5	1	Golgi apparatus;Nucleus speckle;Cell membrane	Stueve-Wiedemann syndrome	Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.	NA	Belongs to the type I cytokine receptor family. Type 2 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;IL-6-type cytokine receptor ligand interactions;RUNX1 regulates transcription of genes involved in interleukin signaling	PE1	5
+NX_P42704	Leucine-rich PPR motif-containing protein, mitochondrial	1394	157905	5.81	0	Nucleus inner membrane;Nucleoplasm;Mitochondrion;Nucleus outer membrane	Leigh syndrome French-Canadian type	May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).	NA	NA	Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	2
+NX_P42765	3-ketoacyl-CoA thiolase, mitochondrial	397	41924	8.32	0	Mitochondrion	NA	In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312).	NA	Belongs to the thiolase-like superfamily. Thiolase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid elongation;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Metabolic pathways;Mitochondrial Fatty Acid Beta-Oxidation	PE1	18
+NX_P42766	60S ribosomal protein L35	123	14551	11.04	0	Endoplasmic reticulum;Cytoplasm;Cytosol;Nucleolus	Diamond-Blackfan anemia 19	Component of the large ribosomal subunit.	NA	Belongs to the universal ribosomal protein uL29 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	9
+NX_P42768	Wiskott-Aldrich syndrome protein	502	52913	6.18	0	Cytosol;Cell membrane;Nucleus;Cytoskeleton	Neutropenia, severe congenital, X-linked;Wiskott-Aldrich syndrome;Thrombocytopenia 1	Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).	Phosphorylated at Tyr-291 by FYN and HCK, inducing WAS effector activity after TCR engagement. Phosphorylation at Tyr-291 enhances WAS activity in promoting actin polymerization and filopodia formation.;WAS is phosphorylated by BTK (Phosphotyrosine:PTM-0255)	NA	Chemokine signaling pathway;Adherens junction;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;Generation of second messenger molecules	PE1	X
+NX_P42771	Cyclin-dependent kinase inhibitor 2A	156	16533	5.52	0	Cytoplasm;Nucleus	Melanoma, cutaneous malignant 2;Familial atypical multiple mole melanoma-pancreatic carcinoma syndrome;Melanoma-astrocytoma syndrome	Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.	Phosphorylation seems to increase interaction with CDK4.;CDKN2A is phosphorylated by PRKCA (Phosphothreonine:PTM-0254)	Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.	Cell cycle;p53 signaling pathway;HTLV-I infection;Pathways in cancer;Pancreatic cancer;Glioma;Melanoma;Bladder cancer;Chronic myeloid leukemia;Non-small cell lung cancer;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Cyclin D associated events in G1;Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4;Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6;Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4;Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	PE1	9
+NX_P42772	Cyclin-dependent kinase 4 inhibitor B	138	14722	6.08	0	Cytoplasm;Nucleoplasm	NA	Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.	NA	Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.	Cell cycle;TGF-beta signaling pathway;HTLV-I infection;Pathways in cancer;Small cell lung cancer;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Cyclin D associated events in G1	PE1	9
+NX_P42773	Cyclin-dependent kinase 4 inhibitor C	168	18127	6.05	0	Nucleoplasm;Cytosol	NA	Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.	NA	Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.	Cell cycle;HTLV-I infection;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Cyclin D associated events in G1	PE1	1
+NX_P42785	Lysosomal Pro-X carboxypeptidase	496	55800	6.76	0	Cytoplasmic vesicle;Lysosome	NA	Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.	NA	Belongs to the peptidase S28 family.	Protein digestion and absorption;Intrinsic Pathway of Fibrin Clot Formation;Neutrophil degranulation	PE1	11
+NX_P42830	C-X-C motif chemokine 5	114	11972	9.17	0	Secreted	NA	Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.	N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Pertussis;Rheumatoid arthritis;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	4
+NX_P42857	Neuronal vesicle trafficking-associated protein 1	185	20913	5.6	1	Endoplasmic reticulum membrane;Endosome membrane;trans-Golgi network membrane;Membrane;Cytoplasmic vesicle membrane;Golgi stack membrane;Lysosome lumen;Recycling endosome membrane;Early endosome membrane;Dendrite;Multivesicular body membrane;Late endosome membrane	NA	Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061).	NA	Belongs to the NSG family.	NA	PE1	4
+NX_P42858	Huntingtin	3142	347603	5.81	0	Cytoplasm;Early endosome;Nucleoplasm;Autophagosome;Cytosol;Nucleus	Huntington disease;Lopes-Maciel-Rodan syndrome	Huntingtin: May play a role in microtubule-mediated transport or vesicle function.;Huntingtin, myristoylated N-terminal fragment: Promotes the formation of autophagic vesicles.	Huntingtin: Cleaved by caspases downstream of the polyglutamine stretch (PubMed:8696339, PubMed:9535906, PubMed:10770929, PubMed:29802276). The resulting N-terminal fragments are cytotoxic and provokes apoptosis (PubMed:10770929).;Huntingtin, myristoylated N-terminal fragment: Myristoylated at Gly-551, following proteolytic cleavage at Asp-550.;Huntingtin: Phosphorylation at Ser-1179 and Ser-1199 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity.;Huntingtin: Forms with expanded polyglutamine expansion are specifically ubiquitinated by SYVN1, which promotes their proteasomal degradation.	Belongs to the huntingtin family.	Huntington's disease;Regulation of MECP2 expression and activity	PE1	4
+NX_P42892	Endothelin-converting enzyme 1	770	87164	5.61	1	Cell membrane	Hirschsprung disease, cardiac defects, and autonomic dysfunction	Converts big endothelin-1 to endothelin-1.	NA	Belongs to the peptidase M13 family.	Peptide ligand-binding receptors	PE1	1
+NX_P42898	Methylenetetrahydrofolate reductase	656	74597	5.22	0	Cell junction	Methylenetetrahydrofolate reductase deficiency;Ischemic stroke;Schizophrenia;Neural tube defects, folate-sensitive	Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.	NA	Belongs to the methylenetetrahydrofolate reductase family.	One-carbon metabolism; tetrahydrofolate interconversion.;One carbon pool by folate;Metabolic pathways;Metabolism of folate and pterines	PE1	1
+NX_P43003	Excitatory amino acid transporter 1	542	59572	8.52	8	Mitochondrion;Nucleolus;Cell membrane	Episodic ataxia 6	Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).	Glycosylated.	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A3 subfamily.	Glutamatergic synapse;Glutamate Neurotransmitter Release Cycle;Astrocytic Glutamate-Glutamine Uptake And Metabolism;Transport of inorganic cations/anions and amino acids/oligopeptides;Defective SLC1A3 causes episodic ataxia 6 (EA6)	PE1	5
+NX_P43004	Excitatory amino acid transporter 2	574	62104	6.09	8	Cell membrane	Epileptic encephalopathy, early infantile, 41	Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).	Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity.;Glycosylated.	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily.	Glutamatergic synapse;Amyotrophic lateral sclerosis (ALS);Glutamate Neurotransmitter Release Cycle;Astrocytic Glutamate-Glutamine Uptake And Metabolism;Transport of inorganic cations/anions and amino acids/oligopeptides	PE1	11
+NX_P43005	Excitatory amino acid transporter 3	524	57100	5.56	8	Cell membrane;Synaptosome;Recycling endosome membrane;Early endosome membrane;Apical cell membrane;Late endosome membrane	Schizophrenia 18;Dicarboxylic aminoaciduria	Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity).	Glycosylated.	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A1 subfamily.	Glutamatergic synapse;Protein digestion and absorption;Glutamate Neurotransmitter Release Cycle;Transport of inorganic cations/anions and amino acids/oligopeptides;Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	PE1	9
+NX_P43007	Neutral amino acid transporter A	532	55723	5.88	9	Membrane;Centrosome;Melanosome	Spastic tetraplegia, thin corpus callosum, and progressive microcephaly	Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.	NA	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A4 subfamily.	Amino acid transport across the plasma membrane	PE1	2
+NX_P43026	Growth/differentiation factor 5	501	55411	9.82	0	Secreted;Cell membrane	Du Pan syndrome;Acromesomelic chondrodysplasia, Hunter-Thompson type;Multiple synostoses syndrome 2;Brachydactyly A1, C;Brachydactyly C;Osteoarthritis 5;Brachydactyly A2;Acromesomelic chondrodysplasia, Grebe type;Symphalangism, proximal 1B	Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).	NA	Belongs to the TGF-beta family.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Molecules associated with elastic fibres	PE1	20
+NX_P43034	Platelet-activating factor acetylhydrolase IB subunit alpha	410	46638	6.97	0	Spindle;Centrosome;Nucleus membrane;Cytoskeleton	Subcortical band heterotopia;Lissencephaly 1;Miller-Dieker lissencephaly syndrome	Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769).	NA	Belongs to the WD repeat LIS1/nudF family.	Ether lipid metabolism;Metabolic pathways;Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Recruitment of NuMA to mitotic centrosomes;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2	PE1	17
+NX_P43080	Guanylyl cyclase-activating protein 1	201	22920	4.34	0	Membrane;Photoreceptor outer segment;Cell membrane	Cone dystrophy 3	Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:19459154). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity).	NA	NA	Olfactory transduction;Phototransduction;Inactivation, recovery and regulation of the phototransduction cascade	PE1	6
+NX_P43088	Prostaglandin F2-alpha receptor	359	40055	9.19	7	Cell membrane	NA	Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Prostanoid ligand receptors	PE1	1
+NX_P43115	Prostaglandin E2 receptor EP3 subtype	390	43310	9.73	7	Cell membrane	NA	Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Prostanoid ligand receptors	PE1	1
+NX_P43116	Prostaglandin E2 receptor EP2 subtype	358	39761	9.37	7	Cell membrane	NA	Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Prostanoid ligand receptors	PE1	14
+NX_P43119	Prostacyclin receptor	386	40956	8.9	7	Cell membrane	NA	Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.	Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.;Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;G alpha (s) signalling events;Prostanoid ligand receptors;Prostacyclin signalling through prostacyclin receptor	PE1	19
+NX_P43121	Cell surface glycoprotein MUC18	646	71607	5.58	1	Membrane;Cell membrane	NA	Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.	NA	NA	NA	PE1	11
+NX_P43146	Netrin receptor DCC	1447	158457	6.32	1	Membrane;Golgi apparatus	Gaze palsy, familial horizontal, with progressive scoliosis, 2, with impaired intellectual development;Mirror movements 1	Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.	Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.	Belongs to the immunoglobulin superfamily. DCC family.	Axon guidance;Pathways in cancer;Colorectal cancer;DSCAM interactions;Netrin-1 signaling;Caspase activation via Dependence Receptors in the absence of ligand;Role of second messengers in netrin-1 signaling;Netrin mediated repulsion signals;DCC mediated attractive signaling;Regulation of commissural axon pathfinding by SLIT and ROBO	PE1	18
+NX_P43155	Carnitine O-acetyltransferase	626	70858	8.63	0	Mitochondrion;Nucleus membrane;Endoplasmic reticulum;Peroxisome;Nucleoplasm;Mitochondrion inner membrane	Neurodegeneration with brain iron accumulation 8	Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. May be specific for short chain fatty acids.	NA	Belongs to the carnitine/choline acetyltransferase family.	Peroxisome;Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import	PE1	9
+NX_P43166	Carbonic anhydrase 7	264	29658	6.92	0	Cytoplasm	NA	Reversible hydration of carbon dioxide.	NA	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Reversible hydration of carbon dioxide	PE1	16
+NX_P43220	Glucagon-like peptide 1 receptor	463	53026	8.49	7	Cell membrane	NA	G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).	N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-type ligand receptors	PE1	6
+NX_P43234	Cathepsin O	321	35958	7.06	0	Lysosome	NA	Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.	NA	Belongs to the peptidase C1 family.	Lysosome;MHC class II antigen presentation	PE1	4
+NX_P43235	Cathepsin K	329	36966	8.72	0	Cytoplasmic vesicle;Lysosome	Pycnodysostosis	Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.	NA	Belongs to the peptidase C1 family.	Lysosome;Osteoclast differentiation;Toll-like receptor signaling pathway;Rheumatoid arthritis;Degradation of the extracellular matrix;MHC class II antigen presentation;Collagen degradation;Trafficking and processing of endosomal TLR;Activation of Matrix Metalloproteinases;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	PE1	1
+NX_P43243	Matrin-3	847	94623	5.87	0	Nucleoplasm;Nucleus matrix	Amyotrophic lateral sclerosis 21	May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233).	NA	NA	NA	PE1	5
+NX_P43246	DNA mismatch repair protein Msh2	934	104743	5.58	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus;Chromosome	Endometrial cancer;Colorectal cancer;Muir-Torre syndrome;Hereditary non-polyposis colorectal cancer 1;Mismatch repair cancer syndrome	Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containg DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.	Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.;MSH2 is phosphorylated by PRKCZ (Phosphothreonine:PTM-0254)	Belongs to the DNA mismatch repair MutS family.	Mismatch repair;Pathways in cancer;Colorectal cancer;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);TP53 Regulates Transcription of DNA Repair Genes;Defective Mismatch Repair Associated With MSH2;Defective Mismatch Repair Associated With MSH3;Defective Mismatch Repair Associated With MSH6	PE1	2
+NX_P43250	G protein-coupled receptor kinase 6	576	65991	8.32	0	Membrane;Mitochondrion	NA	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).	It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Chemokine signaling pathway;Endocytosis;G alpha (s) signalling events	PE1	5
+NX_P43251	Biotinidase	543	61133	5.81	0	Extracellular space	Biotinidase deficiency	Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.	NA	Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.	Biotin metabolism;Metabolic pathways;Vitamin digestion and absorption;Biotin transport and metabolism;Defective BTD causes biotidinase deficiency	PE1	3
+NX_P43268	ETS translocation variant 4	484	53938	5.31	0	Nucleus;Nucleolus	NA	Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.	Sumoylated; enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2.	Belongs to the ETS family.	MAPK6/MAPK4 signaling	PE1	17
+NX_P43304	Glycerol-3-phosphate dehydrogenase, mitochondrial	727	80853	7.58	0	Mitochondrion	NA	NA	NA	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.;Glycerophospholipid metabolism;Synthesis of PA;Triglyceride catabolism	PE1	2
+NX_P43307	Translocon-associated protein subunit alpha	286	32235	4.39	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.	NA	Belongs to the TRAP-alpha family.	Protein processing in endoplasmic reticulum;XBP1(S) activates chaperone genes;SRP-dependent cotranslational protein targeting to membrane	PE1	6
+NX_P43308	Translocon-associated protein subunit beta	183	20135	7.94	1	Endoplasmic reticulum membrane	NA	TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.	NA	Belongs to the TRAP-beta family.	Protein processing in endoplasmic reticulum;SRP-dependent cotranslational protein targeting to membrane	PE1	1
+NX_P43320	Beta-crystallin B2	205	23380	6.5	0	Nucleoplasm	Cataract 3, multiple types	Crystallins are the dominant structural components of the vertebrate eye lens.	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	22
+NX_P43351	DNA repair protein RAD52 homolog	418	46169	8.49	0	Nucleus speckle;Nucleus;Cell membrane	NA	Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.	Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.	Belongs to the RAD52 family.	Homologous recombination;SUMOylation of DNA damage response and repair proteins;HDR through Single Strand Annealing (SSA)	PE1	12
+NX_P43353	Aldehyde dehydrogenase family 3 member B1	468	51840	7.55	0	Cell membrane	NA	Oxidizes medium and long chain saturated and unsaturated aldehydes (PubMed:17382292, PubMed:23721920). Metabolizes also benzaldehyde (PubMed:17382292). Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920). May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor (PubMed:17382292). May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292).	Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.	Belongs to the aldehyde dehydrogenase family.	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.;Glycolysis / Gluconeogenesis;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;beta-Alanine metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Sphingolipid de novo biosynthesis;Neutrophil degranulation	PE1	11
+NX_P43354	Nuclear receptor subfamily 4 group A member 2	598	66591	8.19	0	Cytoplasm;Nucleus speckle;Nucleus	NA	Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).	NR4A2 is phosphorylated by NLK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the nuclear hormone receptor family. NR4 subfamily.	Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors	PE1	2
+NX_P43355	Melanoma-associated antigen 1	309	34342	4.83	0	Cytoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.	NA	NA	NA	PE1	X
+NX_P43356	Melanoma-associated antigen 2	314	35055	4.7	0	Nucleus;PML body	NA	Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.	NA	NA	NA	PE1	X
+NX_P43357	Melanoma-associated antigen 3	314	34747	4.57	0	NA	NA	Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.	NA	NA	NA	PE1	X
+NX_P43358	Melanoma-associated antigen 4	317	34899	4.68	0	Cytosol;Nucleus speckle	NA	Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	NA	NA	NA	PE1	X
+NX_P43359	Melanoma-associated antigen 5	124	13016	4.63	0	NA	NA	Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.	NA	NA	NA	PE2	X
+NX_P43360	Melanoma-associated antigen 6	314	34891	4.57	0	NA	NA	Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.	NA	NA	NA	PE1	X
+NX_P43361	Melanoma-associated antigen 8	318	35215	4.71	0	NA	NA	Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	NA	NA	NA	PE1	X
+NX_P43362	Melanoma-associated antigen 9	315	35088	4.49	0	Golgi apparatus;Nucleoplasm	NA	Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	NA	NA	NA	PE1	X
+NX_P43363	Melanoma-associated antigen 10	369	40780	4.32	0	Nucleoplasm;Cytosol;Nucleus	NA	Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	NA	NA	NA	PE1	X
+NX_P43364	Melanoma-associated antigen 11	429	48129	4.69	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.	NA	NA	NA	PE1	X
+NX_P43365	Melanoma-associated antigen 12	314	34836	4.71	0	NA	NA	Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.	NA	NA	NA	PE1	X
+NX_P43366	Melanoma-associated antigen B1	347	39037	8.56	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_P43378	Tyrosine-protein phosphatase non-receptor type 9	593	68020	8.19	0	Cytoplasm;Cytoplasmic vesicle	NA	Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily.	Interleukin-37 signaling	PE1	15
+NX_P43403	Tyrosine-protein kinase ZAP-70	619	69872	7.78	0	Cytoplasm;Cell membrane	Autoimmune disease, multisystem, infantile-onset, 2;Immunodeficiency 48	Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR).	Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Phosphorylation of Tyr-315 and Tyr-319 are essential for ZAP70 positive function on T-lymphocyte activation whereas Tyr-292 has a negative regulatory role. Within the C-terminal kinase domain, Tyr-492 and Tyr-493 are phosphorylated after TCR induction, Tyr-492 playing a negative regulatory role and Tyr-493 a positive. Tyr-493 is dephosphorylated by PTN22.;Ubiquitinated in response to T cell activation. Deubiquitinated by OTUD7B.	Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.	Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;Primary immunodeficiency;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules	PE1	2
+NX_P43405	Tyrosine-protein kinase SYK	635	72066	8.43	0	Cytoplasmic vesicle;Cytosol;Cell membrane	NA	Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity).	Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation.;Autophosphorylated. Phosphorylated on tyrosine residues by LYN following receptors engagement. Phosphorylation on Tyr-323 creates a binding site for CBL, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling. Phosphorylation at Tyr-348 creates a binding site for VAV1. Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3-kinase-independent pathway (By similarity). Phosphorylated on tyrosine residues in response to IL15 (PubMed:15123770). Phosphorylation on Ser-297 is very common, it peaks 5 minutes after BCR stimulation, and creates a binding site for YWHAG. Phosphorylation at Tyr-630 creates a binding site for BLNK. Dephosphorylated by PTPN6.;SYK is phosphorylated by FGR (Phosphotyrosine:PTM-0255);SYK is phosphorylated by PAK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SYK is phosphorylated by JAK1	Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.	Osteoclast differentiation;Natural killer cell mediated cytotoxicity;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Tuberculosis;CLEC7A (Dectin-1) signaling;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;GPVI-mediated activation cascade;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Dectin-2 family;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;FCGR activation;Fc epsilon receptor (FCERI) signaling;Regulation of signaling by CBL;Integrin alphaIIb beta3 signaling;Interleukin-2 signaling	PE1	9
+NX_P43487	Ran-specific GTPase-activating protein	201	23310	5.19	0	Cytoplasm;Cytosol	NA	Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7882974, PubMed:7616957).	NA	Belongs to the RANBP1 family.	HTLV-I infection;Rev-mediated nuclear export of HIV RNA	PE1	22
+NX_P43489	Tumor necrosis factor receptor superfamily member 4	277	29341	8.68	1	Membrane	Immunodeficiency 16	(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.;Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.	NA	NA	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	1
+NX_P43490	Nicotinamide phosphoribosyltransferase	491	55521	6.69	0	Cytoplasm;Nucleus speckle;Cell junction;Secreted;Nucleus	NA	Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).	NA	Belongs to the NAPRTase family.	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.;Nicotinate and nicotinamide metabolism;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Nicotinamide salvaging	PE1	7
+NX_P43626	Killer cell immunoglobulin-like receptor 2DL1	348	38505	6.34	1	Cell membrane	NA	Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.	NA	Belongs to the immunoglobulin superfamily.	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Graft-versus-host disease;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_P43627	Killer cell immunoglobulin-like receptor 2DL2	348	38472	6.46	1	Cell membrane	NA	Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.	NA	Belongs to the immunoglobulin superfamily.	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Graft-versus-host disease;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_P43628	Killer cell immunoglobulin-like receptor 2DL3	341	37886	6.23	1	Cell membrane	NA	Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.	NA	Belongs to the immunoglobulin superfamily.	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Graft-versus-host disease;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_P43629	Killer cell immunoglobulin-like receptor 3DL1	444	49098	9.02	1	Cell membrane	NA	Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.	NA	Belongs to the immunoglobulin superfamily.	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Graft-versus-host disease;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_P43630	Killer cell immunoglobulin-like receptor 3DL2	455	50230	8.78	1	Cell membrane	NA	Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952). Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270). Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).	NA	Belongs to the immunoglobulin superfamily.	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Graft-versus-host disease;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_P43631	Killer cell immunoglobulin-like receptor 2DS2	304	33502	6.13	1	Cell membrane	NA	Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.	NA	Belongs to the immunoglobulin superfamily.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 interactions	PE1	19
+NX_P43632	Killer cell immunoglobulin-like receptor 2DS4	304	33583	5.98	1	Cell membrane	NA	Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.	NA	Belongs to the immunoglobulin superfamily.	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;DAP12 interactions	PE1	19
+NX_P43652	Afamin	599	69069	5.64	0	Secreted	NA	Functions as carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B (PubMed:26902720). Binds vitamin E (PubMed:15952736, PubMed:12463752). May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient (PubMed:15952736). May be involved in the transport of vitamin E across the blood-brain barrier (PubMed:19046407).	N-glycosylated; more than 90% of the glycans are sialylated.	Belongs to the ALB/AFP/VDB family.	NA	PE1	4
+NX_P43657	Lysophosphatidic acid receptor 6	344	39392	9.22	7	Cell membrane	Hypotrichosis 8;Woolly hair autosomal recessive 1 with or without hypotrichosis	Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;P2Y receptors	PE1	13
+NX_P43681	Neuronal acetylcholine receptor subunit alpha-4	627	69957	6.81	4	Postsynaptic cell membrane;Cell membrane	Epilepsy, nocturnal frontal lobe, 1	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.	Neuroactive ligand-receptor interaction;Cholinergic synapse;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly sodium permeable acetylcholine nicotinic receptors;Highly calcium permeable nicotinic acetylcholine receptors	PE1	20
+NX_P43686	26S proteasome regulatory subunit 6B	418	47366	5.09	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.	NA	Belongs to the AAA ATPase family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	19
+NX_P43694	Transcription factor GATA-4	442	44565	9.39	0	Nucleus	Ventricular septal defect 1;Atrioventricular septal defect 4;Testicular anomalies with or without congenital heart disease;Tetralogy of Fallot;Atrial septal defect 2	Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).	Methylation at Lys-300 attenuates transcriptional activity.	NA	Factors involved in megakaryocyte development and platelet production;Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);YAP1- and WWTR1 (TAZ)-stimulated gene expression;Physiological factors	PE1	8
+NX_P43699	Homeobox protein Nkx-2.1	371	38596	9.72	0	Golgi apparatus;Nucleus;Cytoplasmic vesicle	Thyroid cancer, non-medullary, 1;Choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction;Chorea, hereditary benign	Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).	Phosphorylated on serine residues by STK3/MST2.;NKX2-1 is phosphorylated by STK3	Belongs to the NK-2 homeobox family.	NA	PE1	14
+NX_P43897	Elongation factor Ts, mitochondrial	325	35391	8.62	0	Nucleoplasm;Mitochondrion	Combined oxidative phosphorylation deficiency 3	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.	NA	Belongs to the EF-Ts family.	Mitochondrial translation elongation	PE1	12
+NX_P45378	Troponin T, fast skeletal muscle	269	31825	5.71	0	NA	Arthrogryposis, distal, 2B2	Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	NA	Belongs to the troponin T family.	Striated Muscle Contraction	PE1	11
+NX_P45379	Troponin T, cardiac muscle	298	35924	4.94	0	Nucleoplasm;Focal adhesion;Nucleolus	Cardiomyopathy, dilated 1D;Cardiomyopathy, familial restrictive 3;Cardiomyopathy, familial hypertrophic 2	Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.;TNNT2 is phosphorylated by PRKCE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the troponin T family.	Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Striated Muscle Contraction	PE1	1
+NX_P45381	Aspartoacylase	313	35735	6.06	0	Cytoplasm;Cytosol;Nucleus	Canavan disease	Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.	NA	Belongs to the AspA/AstE family. Aspartoacylase subfamily.	Alanine, aspartate and glutamate metabolism;Histidine metabolism;Aspartate and asparagine metabolism	PE1	17
+NX_P45452	Collagenase 3	471	53820	5.32	0	Extracellular matrix;Secreted	Metaphyseal anadysplasia 1;Spondyloepimetaphyseal dysplasia Missouri type;Metaphyseal dysplasia, Spahr type	Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.	N-glycosylated.;Tyrosine phosphorylated by PKDCC/VLK.;The proenzyme is activated by removal of the propeptide; this cleavage can be effected by other matrix metalloproteinases, such as MMP2, MMP3 and MMP14 and may involve several cleavage steps. Cleavage can also be autocatalytic, after partial maturation by another protease or after treatment with 4-aminophenylmercuric acetate (APMA) (in vitro).	Belongs to the peptidase M10A family.	Degradation of the extracellular matrix;Collagen degradation;Assembly of collagen fibrils and other multimeric structures;Activation of Matrix Metalloproteinases;RUNX2 regulates genes involved in cell migration	PE1	11
+NX_P45844	ATP-binding cassette sub-family G member 1	678	75592	8.02	6	Golgi apparatus;Endoplasmic reticulum membrane;Cell membrane;Golgi apparatus membrane;Cytoplasmic vesicle	NA	Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620).	Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.	ABC transporters;ABC transporters in lipid homeostasis;HDL remodeling	PE1	21
+NX_P45877	Peptidyl-prolyl cis-trans isomerase C	212	22763	8.48	0	Cytoplasm	NA	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.	NA	Belongs to the cyclophilin-type PPIase family.	NA	PE1	5
+NX_P45880	Voltage-dependent anion-selective channel protein 2	294	31567	7.5	19	Mitochondrion outer membrane;Mitochondrion	NA	Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	Belongs to the eukaryotic mitochondrial porin family.	Calcium signaling pathway;Parkinson's disease;Huntington's disease;HTLV-I infection;Ub-specific processing proteases;Mitochondrial calcium ion transport	PE1	10
+NX_P45954	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	432	47485	6.53	0	Mitochondrion matrix;Mitochondrion	Short/branched-chain acyl-CoA dehydrogenase deficiency	Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent.	NA	Belongs to the acyl-CoA dehydrogenase family.	Lipid metabolism; mitochondrial fatty acid beta-oxidation.;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Metabolic pathways;Branched-chain amino acid catabolism	PE1	10
+NX_P45973	Chromobox protein homolog 5	191	22225	5.71	0	Nucleoplasm;Centromere;Nucleus;Chromosome	NA	Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.	Ubiquitinated.;Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.	NA	Factors involved in megakaryocyte development and platelet production;SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6	PE1	12
+NX_P45974	Ubiquitin carboxyl-terminal hydrolase 5	858	95786	4.91	0	Nucleoplasm;Cytosol	NA	Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.	NA	Belongs to the peptidase C19 family.	Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	12
+NX_P45983	Mitogen-activated protein kinase 8	427	48296	6.43	0	Cytoplasm;Nucleus	NA	JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.;Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity).	Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme (PubMed:11062067). Phosphorylated by TAOK2 (PubMed:17158878). May be phosphorylated at Thr-183 and Tyr-185 by MAP3K1/MEKK1 (PubMed:17761173).;MAPK8 is phosphorylated by PRKDC (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK signaling pathway;ErbB signaling pathway;Protein processing in endoplasmic reticulum;Wnt signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Fc epsilon RI signaling pathway;Neurotrophin signaling pathway;Dopaminergic synapse;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Adipocytokine signaling pathway;Type II diabetes mellitus;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Salmonella infection;Pertussis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Hepatitis C;Influenza A;HTLV-I infection;Herpes simplex infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;DSCAM interactions;Oxidative Stress Induced Senescence;NRAGE signals death through JNK;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors;NRIF signals cell death from the nucleus;Activation of BIM and translocation to mitochondria;Activation of BMF and translocation to mitochondria;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Interleukin-38 signaling	PE1	10
+NX_P45984	Mitogen-activated protein kinase 9	424	48139	5.41	0	Cytoplasm;Nucleus	NA	MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.;Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity).	Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK signaling pathway;ErbB signaling pathway;Protein processing in endoplasmic reticulum;Wnt signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Neurotrophin signaling pathway;Dopaminergic synapse;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Adipocytokine signaling pathway;Type II diabetes mellitus;Epithelial cell signaling in Helicobacter pylori infection;Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors	PE1	5
+NX_P45985	Dual specificity mitogen-activated protein kinase kinase 4	399	44288	8.28	0	Cytoplasm;Nucleoplasm;Cell junction;Nucleus	NA	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.	Activated by phosphorylation on Ser-257 and Thr-261 by MAP kinase kinase kinases (MAP3Ks).;MAP2K4 is phosphorylated by MAP3K1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K4 is phosphorylated by MAP3K9 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K4 is phosphorylated by MAP3K4 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K4 is phosphorylated by MAP3K5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K4 is phosphorylated by MAP3K8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	MAPK signaling pathway;ErbB signaling pathway;Toll-like receptor signaling pathway;Fc epsilon RI signaling pathway;GnRH signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Chagas disease (American trypanosomiasis);Influenza A;HTLV-I infection;Oxidative Stress Induced Senescence;Uptake and function of anthrax toxins;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;MAP3K8 (TPL2)-dependent MAPK1/3 activation	PE1	17
+NX_P46013	Proliferation marker protein Ki-67	3256	358694	9.49	0	Nucleoplasm;Nucleus;Nucleolus;Chromosome	NA	Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).	Phosphorylated. Hyperphosphorylated in mitosis (PubMed:10502411, PubMed:10653604). Hyperphosphorylated form does not bind DNA.	NA	NA	PE1	10
+NX_P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	1235	138408	5.99	0	Nucleoplasm;Cell membrane	Glycogen storage disease 9A	Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.	Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.	Belongs to the phosphorylase b kinase regulatory chain family.	Glycan biosynthesis; glycogen metabolism.;Calcium signaling pathway;Insulin signaling pathway;Glycogen breakdown (glycogenolysis)	PE1	X
+NX_P46020	Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform	1223	137312	5.8	0	Cytoplasmic vesicle;Cell membrane	Glycogen storage disease 9D	Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.	Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.	Belongs to the phosphorylase b kinase regulatory chain family.	Glycan biosynthesis; glycogen metabolism.;Calcium signaling pathway;Insulin signaling pathway;Glycogen breakdown (glycogenolysis)	PE1	X
+NX_P46059	Solute carrier family 15 member 1	708	78806	8.72	12	Membrane;Nucleoplasm;Cytosol	NA	Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.	NA	Belongs to the PTR2/POT transporter (TC 2.A.17) family.	Protein digestion and absorption;Proton/oligopeptide cotransporters	PE1	13
+NX_P46060	Ran GTPase-activating protein 1	587	63542	4.63	0	Cytoplasm;Nucleus membrane;Nucleoplasm;Nucleus envelope;Cytoplasmic vesicle;Cytosol;Spindle;Kinetochore	NA	GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).	Phosphorylation occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBE2I, on nuclear pore complex (NPC) diassembly and during mitosis.;Sumoylated (PubMed:11854305, PubMed:15037602, PubMed:26304119, PubMed:27160050). Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis (PubMed:11854305). Also required for interaction with RANBP2 and is mediated by UBE2I (PubMed:27160050).	Belongs to the RNA1 family.	RNA transport;Separation of Sister Chromatids;Rev-mediated nuclear export of HIV RNA;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;SUMOylation of DNA replication proteins	PE1	22
+NX_P46063	ATP-dependent DNA helicase Q1	649	73457	8.13	0	Nucleoplasm;Nucleus	NA	DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.	NA	Belongs to the helicase family. RecQ subfamily.	NA	PE1	12
+NX_P46087	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase	812	89302	9.27	0	Nucleolus;Nucleus	NA	Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).	Citrullinated by PADI4.	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	rRNA modification in the nucleus and cytosol;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	PE1	12
+NX_P46089	G-protein coupled receptor 3	330	35010	8.4	7	Cell membrane	NA	Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	1
+NX_P46091	G-protein coupled receptor 1	355	41431	6.98	7	Cytoplasmic vesicle;Nucleoplasm;Cell membrane	NA	Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (PubMed:18165312). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).;(Microbial infection) Coreceptor for HIV-1.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	2
+NX_P46092	C-C chemokine receptor type 10	362	38416	9.85	7	Endoplasmic reticulum;Cell membrane	NA	Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.	NA	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Intestinal immune network for IgA production;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	17
+NX_P46093	G-protein coupled receptor 4	362	40982	8.82	7	Cell membrane	NA	Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (q) signalling events;Class A/1 (Rhodopsin-like receptors)	PE2	19
+NX_P46094	Chemokine XC receptor 1	333	38508	8.94	7	Cell membrane	NA	Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.	NA	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (q) signalling events;Chemokine receptors bind chemokines	PE1	3
+NX_P46095	G-protein coupled receptor 6	362	37881	7.61	7	Cell membrane	NA	Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	6
+NX_P46098	5-hydroxytryptamine receptor 3A	478	55280	7.04	4	Cell membrane;Postsynaptic cell membrane	NA	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily.	Neurotransmitter receptors and postsynaptic signal transmission	PE1	11
+NX_P46100	Transcriptional regulator ATRX	2492	282586	6.2	0	PML body;Telomere;Nucleus	Alpha-thalassemia mental retardation syndrome, X-linked;Alpha-thalassemia myelodysplasia syndrome;Mental retardation-hypotonic facies syndrome, X-linked, 1	Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone H2AFY, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610).	Phosphorylated at serine residues during mitose. Phosphorylation may promote the release from the nuclear matrix and progression to mitosis.	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	X
+NX_P46108	Adapter molecule crk	304	33831	5.38	0	Cytoplasm;Cell membrane	NA	Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.	Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form.;Is phosphorylated by KIT.;Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form.;Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway.;CRK is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255);CRK is phosphorylated by FGFR1	Belongs to the CRK family.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Focal adhesion;Fc gamma R-mediated phagocytosis;Neurotrophin signaling pathway;Regulation of actin cytoskeleton;Insulin signaling pathway;Bacterial invasion of epithelial cells;Shigellosis;Pathways in cancer;Renal cell carcinoma;Chronic myeloid leukemia;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;ARMS-mediated activation;Regulation of signaling by CBL;Downstream signal transduction;p130Cas linkage to MAPK signaling for integrins;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;MET receptor recycling	PE1	17
+NX_P46109	Crk-like protein	303	33777	6.26	0	Nucleoplasm;Cytosol;Cell membrane	NA	May mediate the transduction of intracellular signals.	NA	Belongs to the CRK family.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Focal adhesion;Fc gamma R-mediated phagocytosis;Neurotrophin signaling pathway;Regulation of actin cytoskeleton;Insulin signaling pathway;Bacterial invasion of epithelial cells;Shigellosis;Pathways in cancer;Renal cell carcinoma;Chronic myeloid leukemia;Regulation of signaling by CBL;Frs2-mediated activation;Downstream signal transduction;MET activates RAP1 and RAC1;MET receptor recycling;Erythropoietin activates RAS	PE1	22
+NX_P46199	Translation initiation factor IF-2, mitochondrial	727	81317	6.71	0	Mitochondrion	NA	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.	Mitochondrial translation initiation	PE1	2
+NX_P46379	Large proline-rich protein BAG6	1132	119409	5.4	0	Extracellular exosome;Nucleoplasm;Cytosol;Nucleus	NA	Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).;ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:28104892, PubMed:27193484). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate to the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).;Mediates ricin-induced apoptosis.;Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639).	Ricin can induce a cleavage by the caspase CASP3. The released C-terminal peptide induces apoptosis.;(Microbial infection) In case of infection by L.pneumophila, ubiquitinated by the SCF(LegU1) complex.	NA	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	6
+NX_P46439	Glutathione S-transferase Mu 5	218	25675	6.91	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.	NA	Belongs to the GST superfamily. Mu family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation	PE1	1
+NX_P46459	Vesicle-fusing ATPase	744	82594	6.52	0	Cytoplasm;Cytosol	NA	Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).	Phosphorylation at Ser-569 interferes with homohexamerization.	Belongs to the AAA ATPase family.	Synaptic vesicle cycle;GABAergic synapse;Vasopressin-regulated water reabsorption;COPII-mediated vesicle transport;Trafficking of GluR2-containing AMPA receptors;Intra-Golgi traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network	PE1	17
+NX_P46527	Cyclin-dependent kinase inhibitor 1B	198	22073	6.54	0	Cytoplasm;Nucleoplasm;Endosome;Cytoplasmic vesicle;Nucleus	Multiple endocrine neoplasia 4	Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	Subject to degradation in the lysosome. Interaction with SNX6 promotes lysosomal degradation (By similarity).;Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK1 and CDK2 leads to protein ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF.;Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like complex; leads to its degradation.	Belongs to the CDI family.	ErbB signaling pathway;Cell cycle;Measles;Pathways in cancer;Prostate cancer;Chronic myeloid leukemia;Small cell lung cancer;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SCF(Skp2)-mediated degradation of p27/p21;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry;Constitutive Signaling by AKT1 E17K in Cancer;Cyclin D associated events in G1;AKT phosphorylates targets in the cytosol;RHO GTPases activate CIT;p53-Dependent G1 DNA Damage Response;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;PTK6 Regulates Cell Cycle;Estrogen-dependent nuclear events downstream of ESR-membrane signaling;FOXO-mediated transcription of cell cycle genes	PE1	12
+NX_P46531	Neurogenic locus notch homolog protein 1	2555	272505	4.95	1	Nucleoplasm;Nucleus;Cell membrane	Adams-Oliver syndrome 5;Aortic valve disease 1	Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).	Phosphorylated.;O-glycosylated on the EGF-like domains (PubMed:24226769). O-glucosylated at Ser-435 by KDELC1 and KDELC2 (PubMed:30127001). Contains both O-linked fucose and O-linked glucose in the EGF-like domains 11, 12 and 13, which are interacting with the residues on DLL4 (By similarity). O-linked glycosylation by GALNT11 is involved in determination of left/right symmetry: glycosylation promotes activation of NOTCH1, possibly by promoting cleavage by ADAM17, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (PubMed:24226769). MFNG-, RFNG- and LFNG-mediated modification of O-fucose residues at specific EGF-like domains results in inhibition of its activation by JAG1 and enhancement of its activation by DLL1 via an increased binding to DLL1 (By similarity).;Hydroxylated at Asn-1955 by HIF1AN. Hydroxylated at Asn-2022 by HIF1AN (By similarity). Hydroxylation reduces affinity for HI1AN and may thus indirectly modulate negative regulation of NICD (By similarity).;Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form (By similarity). Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by ADAM17 to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT) (PubMed:24226769). Following endocytosis, this fragment is then cleaved by one of the catalytic subunits of gamma-secretase (PSEN1 or PSEN2), to release a Notch-derived peptide containing the intracellular domain (NICD) from the membrane (PubMed:30598546).;Ubiquitinated. Undergoes 'Lys-29'-linked polyubiquitination by ITCH; promotes the lysosomal degradation of non-activated internalized NOTCH1 (PubMed:18628966, PubMed:23886940). Monoubiquitination at Lys-1759 is required for activation by gamma-secretase cleavage, it promotes interaction with AAK1, which stabilizes it. Deubiquitination by EIF3F is necessary for nuclear import of activated Notch (PubMed:24226769).;NOTCH1 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);NOTCH1 is phosphorylated by NLK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the NOTCH family.	Dorso-ventral axis formation;Notch signaling pathway;Prion diseases;Pre-NOTCH Processing in the Endoplasmic Reticulum;Pre-NOTCH Transcription and Translation;Pre-NOTCH Processing in Golgi;Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant;Constitutive Signaling by NOTCH1 HD Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;Defective LFNG causes SCDO3;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE1	9
+NX_P46597	Acetylserotonin O-methyltransferase	345	38453	5.05	0	NA	NA	Lack enzyme activity.;Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.	Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.;Tryptophan metabolism;Metabolic pathways;Serotonin and melatonin biosynthesis	PE1	X
+NX_P46663	B1 bradykinin receptor	353	40495	9.5	7	Cell membrane	NA	This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.	NA	Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Regulation of actin cytoskeleton;G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	14
+NX_P46695	Radiation-inducible immediate-early gene IEX-1	156	16903	8.61	1	Membrane	NA	May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.	Glycosylated.;Phosphorylated at Thr-18, Thr-123 and Ser-126 by MAPK1/ERK2 and probably MAPK3/ERK1. Upon phosphorylation by MAPK1/ERK2 and MAPK3/ERK1, acquires the ability to inhibit cell death induced by various stimuli.	Belongs to the IER3 family.	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	6
+NX_P46721	Solute carrier organic anion transporter family member 1A2	670	74145	5.69	12	Cell membrane	NA	Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.	NA	Belongs to the organo anion transporter (TC 2.A.60) family.	Bile secretion;Transport of organic anions;Recycling of bile acids and salts	PE1	12
+NX_P46734	Dual specificity mitogen-activated protein kinase kinase 3	347	39318	7.05	0	Nucleoplasm;Cytosol	NA	Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.	Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.;Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity (PubMed:8622669). Phosphorylated by TAOK2 (PubMed:11279118).;MAP2K3 is phosphorylated by TAOK1;MAP2K3 is phosphorylated by MAP3K7 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K3 is phosphorylated by MAP3K5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K3 is phosphorylated by TAOK2	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	MAPK signaling pathway;Toll-like receptor signaling pathway;Fc epsilon RI signaling pathway;GnRH signaling pathway;Amyotrophic lateral sclerosis (ALS);Toxoplasmosis;Influenza A;Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;Uptake and function of anthrax toxins	PE1	17
+NX_P46736	Lys-63-specific deubiquitinase BRCC36	316	36072	5.59	0	Nucleoplasm;Spindle pole;Cytoplasm;Nucleus	NA	Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).	NA	Belongs to the peptidase M67A family. BRCC36 subfamily.	G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Metalloprotease DUBs	PE1	X
+NX_P46776	60S ribosomal protein L27a	148	16561	11	0	Endoplasmic reticulum;Nucleus;Nucleolus;Cytosol	NA	NA	Hydroxylated on His-39 by MINA.	Belongs to the universal ribosomal protein uL15 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	11
+NX_P46777	60S ribosomal protein L5	297	34363	9.73	0	Endoplasmic reticulum;Cytosol;Cytoplasm;Nucleolus	Diamond-Blackfan anemia 6	Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868).	NA	Belongs to the universal ribosomal protein uL18 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	1
+NX_P46778	60S ribosomal protein L21	160	18565	10.49	0	Endoplasmic reticulum;Cytosol;Cytoplasm;Nucleolus	Hypotrichosis 12	Component of the large ribosomal subunit.	NA	Belongs to the eukaryotic ribosomal protein eL21 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	13
+NX_P46779	60S ribosomal protein L28	137	15748	12.02	0	Endoplasmic reticulum;Cytosol	NA	Component of the large ribosomal subunit.	NA	Belongs to the eukaryotic ribosomal protein eL28 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_P46781	40S ribosomal protein S9	194	22591	10.66	0	Cytoplasm	NA	NA	NA	Belongs to the universal ribosomal protein uS4 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_P46782	40S ribosomal protein S5	204	22876	9.73	0	Endoplasmic reticulum;Cytosol	NA	NA	NA	Belongs to the universal ribosomal protein uS7 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_P46783	40S ribosomal protein S10	165	18898	10.15	0	Cytoplasm;Nucleolus	Diamond-Blackfan anemia 9	Component of the 40S ribosomal subunit.	Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).;Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.	Belongs to the eukaryotic ribosomal protein eS10 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	6
+NX_P46821	Microtubule-associated protein 1B	2468	270634	4.73	0	Cytoplasm;Dendritic spine;Synapse;Cytosol;Cytoskeleton	NA	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.	S-nitrosylation at Cys-2464 enhances interaction with microtubules, and may act as an effector modification for neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction.;LC1 is generated from MAP1B by proteolytic processing.;MAP1B is phosphorylated by NLK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the MAP1 family.	NA	PE1	5
+NX_P46926	Glucosamine-6-phosphate isomerase 1	289	32669	6.42	0	Cytoplasm	NA	Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).	NA	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.	Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Glycolysis	PE1	5
+NX_P46934	E3 ubiquitin-protein ligase NEDD4	1319	149114	6.15	0	Cytoplasm;Cytosol;Cell membrane	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).;(Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding.	Auto-ubiquitinated.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;ISG15 antiviral mechanism;Downregulation of ERBB4 signaling;Regulation of PTEN stability and activity;Regulation of PTEN localization	PE1	15
+NX_P46937	Transcriptional coactivator YAP1	504	54462	5	0	Nucleolus;Cytoplasm;Nucleoplasm;Nucleus	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).;Can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).	Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.;Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation (PubMed:18158288, PubMed:20048001). Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage (PubMed:18280240). Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation (PubMed:20048001). Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regulation of apoptosis by YAP1 (PubMed:21364637).;YAP1 is phosphorylated by MAPK3	Belongs to the YAP1 family.	Signaling by Hippo;YAP1- and WWTR1 (TAZ)-stimulated gene expression;Nuclear signaling by ERBB4;RUNX3 regulates YAP1-mediated transcription;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX2 regulates osteoblast differentiation	PE1	11
+NX_P46939	Utrophin	3433	394466	5.2	0	Nucleoplasm;Cell membrane;Cytoskeleton;Postsynaptic cell membrane	NA	May play a role in anchoring the cytoskeleton to the plasma membrane.	NA	NA	NA	PE1	6
+NX_P46940	Ras GTPase-activating-like protein IQGAP1	1657	189252	6.08	0	Cytoplasm;Cell junction;Nucleus;Cell membrane	NA	Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816).	Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.	NA	Adherens junction;Regulation of actin cytoskeleton;MAP2K and MAPK activation;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Nephrin family interactions;RHO GTPases activate IQGAPs;Neutrophil degranulation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	15
+NX_P46952	3-hydroxyanthranilate 3,4-dioxygenase	286	32556	5.62	0	Cytosol	Vertebral, cardiac, renal, and limb defects syndrome 1	Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	NA	Belongs to the 3-HAO family.	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.;Tryptophan metabolism;Metabolic pathways;Tryptophan catabolism	PE1	2
+NX_P46976	Glycogenin-1	350	39384	5.27	0	Cytoplasmic vesicle	Polyglucosan body myopathy 2;Glycogen storage disease 15	Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.	Phosphorylated.;Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-195.	Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.	Glycan biosynthesis; glycogen biosynthesis.;Glycogen synthesis;Myoclonic epilepsy of Lafora;Glycogen breakdown (glycogenolysis);Glycogen storage disease type II (GAA);Glycogen storage disease type XV (GYG1);Glycogen storage disease type 0 (muscle GYS1);Neutrophil degranulation	PE1	3
+NX_P46977	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A	705	80530	8.28	13	Endoplasmic reticulum membrane;Endoplasmic reticulum;Nucleoplasm;Cytoplasmic vesicle;Cytosol	Congenital disorder of glycosylation 1W	Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A (PubMed:19167329).	NA	Belongs to the STT3 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;Asparagine N-linked glycosylation	PE1	11
+NX_P47211	Galanin receptor type 1	349	38953	9.55	7	Cell membrane	NA	Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.	Palmitoylated on at least one of the three cysteine residues present in the C-terminal part.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	18
+NX_P47224	Guanine nucleotide exchange factor MSS4	123	13839	5.37	0	Cytoskeleton	NA	Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.	NA	Belongs to the DSS4/MSS4 family.	NA	PE1	1
+NX_P47710	Alpha-S1-casein	185	21671	5.32	0	Secreted	NA	Important role in the capacity of milk to transport calcium phosphate.;Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.	Not glycosylated.	Belongs to the alpha-casein family.	Miscellaneous transport and binding events	PE1	4
+NX_P47712	Cytosolic phospholipase A2	749	85239	5.22	0	Cytoplasmic vesicle;Cytosol;Cytoplasm	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.	Activated by phosphorylation at both Ser-505 and Ser-727.	NA	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Synthesis of PA;ADP signalling through P2Y purinoceptor 1;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC;Platelet sensitization by LDL;phospho-PLA2 pathway;Acyl chain remodeling of CL;Arachidonic acid metabolism;COPI-independent Golgi-to-ER retrograde traffic	PE1	1
+NX_P47736	Rap1 GTPase-activating protein 1	663	73361	5.55	0	Cytosol;Golgi apparatus membrane	NA	GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.	NA	NA	Rap1 signalling;RET signaling	PE1	1
+NX_P47755	F-actin-capping protein subunit alpha-2	286	32949	5.57	0	Endoplasmic reticulum;Cytoplasm;Cytosol	NA	F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	NA	Belongs to the F-actin-capping protein alpha subunit family.	MHC class II antigen presentation;Factors involved in megakaryocyte development and platelet production;Advanced glycosylation endproduct receptor signaling;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	7
+NX_P47756	F-actin-capping protein subunit beta	277	31350	5.36	0	Cytoplasm;Sarcomere;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Cytoskeleton	NA	F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.	NA	Belongs to the F-actin-capping protein beta subunit family.	MHC class II antigen presentation;Factors involved in megakaryocyte development and platelet production;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	1
+NX_P47775	G-protein coupled receptor 12	334	36730	6.63	7	Cell membrane	NA	Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	13
+NX_P47804	RPE-retinal G protein-coupled receptor	291	31874	8.35	7	Membrane	Retinitis pigmentosa 44	Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.	Covalently binds all-trans- and 11-cis-retinal.	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	G alpha (i) signalling events;Opsins	PE1	10
+NX_P47813	Eukaryotic translation initiation factor 1A, X-chromosomal	144	16460	5.07	0	Cytoplasm	NA	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.	NA	Belongs to the eIF-1A family.	RNA transport;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	X
+NX_P47869	Gamma-aminobutyric acid receptor subunit alpha-2	451	51326	9.17	4	Postsynaptic cell membrane;Cytoplasmic vesicle membrane;Dendrite;Cell membrane	NA	Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity).	Glycosylated.	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;GABA receptor activation	PE1	4
+NX_P47870	Gamma-aminobutyric acid receptor subunit beta-2	512	59150	9.39	4	Postsynaptic cell membrane;Cytoplasmic vesicle membrane;Cell membrane	Epileptic encephalopathy, infantile or early childhood, 2	Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:8264558, PubMed:19763268, PubMed:27789573, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).	Glycosylated.	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;Signaling by ERBB4;GABA receptor activation	PE1	5
+NX_P47871	Glucagon receptor	477	54009	9.01	7	Golgi apparatus;Cell membrane	NA	G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.	Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding.	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;G alpha (s) signalling events;Glucagon signaling in metabolic regulation;Glucagon-type ligand receptors	PE1	17
+NX_P47872	Secretin receptor	440	50207	7.88	7	Cell membrane	NA	Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:7612008, PubMed:25332973). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity).	Phosphorylated on Ser and Thr residues at the cytoplasmic C-terminus by G protein-coupled receptor kinases (GRKs).	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;Pancreatic secretion;Bile secretion;G alpha (s) signalling events;Glucagon-type ligand receptors	PE1	2
+NX_P47874	Olfactory marker protein	163	18937	5.33	0	Cytoplasm	NA	May act as a modulator of the olfactory signal-transduction cascade.	NA	Belongs to the olfactory marker protein family.	NA	PE1	11
+NX_P47881	Olfactory receptor 3A1	315	34609	9.27	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	17
+NX_P47883	Putative olfactory receptor 3A4	348	37194	6.47	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	17
+NX_P47884	Olfactory receptor 1D4	311	35227	8.29	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE1	17
+NX_P47887	Olfactory receptor 1E2	323	36391	7.9	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	17
+NX_P47888	Olfactory receptor 3A3	321	34963	7.01	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	17
+NX_P47890	Olfactory receptor 1G1	313	34924	6.53	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	17
+NX_P47893	Olfactory receptor 3A2	321	35207	7.56	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	17
+NX_P47895	Aldehyde dehydrogenase family 1 member A3	512	56108	6.99	0	Nucleoplasm;Cytosol;Cytoplasm	Microphthalmia, isolated, 8	NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity).	NA	Belongs to the aldehyde dehydrogenase family.	Cofactor metabolism; retinol metabolism.;Glycolysis / Gluconeogenesis;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;beta-Alanine metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;RA biosynthesis pathway	PE1	15
+NX_P47897	Glutamine--tRNA ligase	775	87799	6.71	0	Cytoplasm;Cytosol	Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy	Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866).	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Metabolic pathways;Mitochondrial tRNA aminoacylation;Cytosolic tRNA aminoacylation;Selenoamino acid metabolism	PE1	3
+NX_P47898	5-hydroxytryptamine receptor 5A	357	40255	9	7	Cell membrane	NA	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Serotonin receptors	PE2	7
+NX_P47900	P2Y purinoceptor 1	373	42072	9.45	7	Cell membrane	NA	Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;P2Y receptors;ADP signalling through P2Y purinoceptor 1	PE1	3
+NX_P47901	Vasopressin V1b receptor	424	46971	9.21	7	Cell membrane	NA	Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;G alpha (q) signalling events;Vasopressin-like receptors;Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)	PE2	1
+NX_P47902	Homeobox protein CDX-1	265	28138	9.58	0	Nucleus	NA	Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).	NA	Belongs to the Caudal homeobox family.	NA	PE1	5
+NX_P47914	60S ribosomal protein L29	159	17752	11.66	0	Cytoplasm;Nucleolus;Endoplasmic reticulum;Cytosol;Nucleus	NA	Component of the large ribosomal subunit.	NA	Belongs to the eukaryotic ribosomal protein eL29 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	3
+NX_P47928	DNA-binding protein inhibitor ID-4	161	16622	8.69	0	Nucleoplasm;Nucleus	NA	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).	NA	NA	TGF-beta signaling pathway	PE1	6
+NX_P47929	Galectin-7	136	15075	7.02	0	Cytoplasm;Secreted;Nucleus	NA	Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.	NA	NA	NA	PE1	19
+NX_P47944	Metallothionein-4	62	6509	8.26	0	NA	NA	Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.	NA	Belongs to the metallothionein superfamily. Type 1 family.	Metallothioneins bind metals	PE2	16
+NX_P47972	Neuronal pentraxin-2	431	47042	5.45	0	Golgi apparatus;Centrosome;Secreted;Cytoskeleton	NA	Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).	NA	NA	NA	PE1	7
+NX_P47974	mRNA decay activator protein ZFP36L2	494	51063	8.52	0	Cytoplasm;Nucleus	NA	Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.	Phosphorylated by RPS6KA1 at Ser-490 and Ser-492 upon phorbol 12-myristate 13-acetate (PMA) treatment; this phosphorylation results in dissociation of the CCR4-NOT-deadenylase complex and induces p38 MAPK-mediated stabilization of the low-density lipoprotein (LDL) receptor (LDLR) mRNA (PubMed:25106868). Phosphorylation occurs during early preadipocyte differentiation (By similarity).	NA	NA	PE1	2
+NX_P47985	Cytochrome b-c1 complex subunit Rieske, mitochondrial	274	29668	8.55	1	Cytoplasm;Mitochondrion inner membrane	NA	Cytochrome b-c1 complex subunit Rieske, mitochondrial: Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (PubMed:28673544). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (PubMed:28673544).;Cytochrome b-c1 complex subunit 9: Possible component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (PubMed:28673544). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer, including this fragment, called subunit 9, which corresponds to the transit peptide (PubMed:28673544). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function (PubMed:28673544). It is therefore unsure whether the UQCRFS1 fragments, including this fragment, are structural subunits (PubMed:28673544).	Proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer (PubMed:28673544). Several fragments are generated during UQCRFS1 insertion, most probably due to the endogenous matrix-processing peptidase (MPP) activity (PubMed:28673544). The action of the protease is also necessary for the clearance of the UQCRFS1 fragments (PubMed:28673544).	NA	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport	PE1	19
+NX_P47989	Xanthine dehydrogenase/oxidase	1333	146424	7.86	0	Cytoplasm;Secreted;Nucleolus;Nucleoplasm;Peroxisome	Xanthinuria 1	Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).	Contains sulfhydryl groups that are easily oxidized (in vitro); this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O).;Subject to partial proteolysis; this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O).	Belongs to the xanthine dehydrogenase family.	Purine metabolism;Caffeine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Peroxisome;Purine catabolism;Butyrophilin (BTN) family interactions	PE1	2
+NX_P47992	Lymphotactin	114	12517	10.22	0	Secreted	NA	Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.	NA	Belongs to the intercrine gamma family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (q) signalling events;Chemokine receptors bind chemokines	PE1	1
+NX_P48023	Tumor necrosis factor ligand superfamily member 6	281	31485	9.41	1	Cell membrane;Secreted;Cytoplasmic vesicle lumen;Lysosome lumen;Nucleus	Autoimmune lymphoproliferative syndrome 1B	FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition.;Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process (PubMed:27806260).;Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260).	Monoubiquitinated.;N-glycosylated (PubMed:9228058). Glycosylation enhances apoptotic activity (PubMed:27806260).;Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.;The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells.;FASLG is phosphorylated by FGR (Phosphotyrosine:PTM-0255)	Belongs to the tumor necrosis factor family.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Apoptosis;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Type I diabetes mellitus;Chagas disease (American trypanosomiasis);African trypanosomiasis;Measles;Influenza A;Herpes simplex infection;Pathways in cancer;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;Caspase activation via Death Receptors in the presence of ligand;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;FasL/ CD95L signaling;Interleukin-4 and Interleukin-13 signaling;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;FOXO-mediated transcription of cell death genes	PE1	1
+NX_P48029	Sodium- and chloride-dependent creatine transporter 1	635	70523	6.02	12	Membrane	Cerebral creatine deficiency syndrome 1	Required for the uptake of creatine in muscles and brain.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.	Creatine metabolism	PE1	X
+NX_P48039	Melatonin receptor type 1A	350	39375	9.55	7	Cell membrane	NA	High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Class A/1 (Rhodopsin-like receptors)	PE1	4
+NX_P48047	ATP synthase subunit O, mitochondrial	213	23277	9.97	0	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.	Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3.	Belongs to the ATPase delta chain family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	21
+NX_P48048	ATP-sensitive inward rectifier potassium channel 1	391	44795	9.03	2	Cell membrane	Bartter syndrome 2, antenatal	In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.	Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane.	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily.	Aldosterone-regulated sodium reabsorption;Gastric acid secretion;Potassium transport channels	PE1	11
+NX_P48050	Inward rectifier potassium channel 4	445	49500	5.82	2	Cytoplasmic vesicle membrane;Cell membrane;Postsynaptic cell membrane	NA	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).	NA	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily.	Cholinergic synapse;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Classical Kir channels;Phase 4 - resting membrane potential	PE1	22
+NX_P48051	G protein-activated inward rectifier potassium channel 2	423	48451	5.24	2	Membrane	Keppen-Lubinsky syndrome	This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.	NA	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.	Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	PE1	21
+NX_P48052	Carboxypeptidase A2	419	47030	5.68	0	Golgi apparatus;Secreted	NA	NA	NA	Belongs to the peptidase M14 family.	Pancreatic secretion;Protein digestion and absorption	PE1	7
+NX_P48058	Glutamate receptor 4	902	100871	8.32	3	Dendrite;Cell membrane;Postsynaptic cell membrane	Neurodevelopmental disorder with or without seizures and gait abnormalities	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.	Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression.;Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;Dopaminergic synapse;Unblocking of NMDA receptors, glutamate binding and activation;Trafficking of AMPA receptors;Trafficking of GluR2-containing AMPA receptors;Activation of AMPA receptors;Synaptic adhesion-like molecules	PE1	11
+NX_P48059	LIM and senescent cell antigen-like-containing domain protein 1	325	37251	8.43	0	Focal adhesion;Cell membrane	NA	Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.	NA	NA	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components;Cell-extracellular matrix interactions	PE1	2
+NX_P48060	Glioma pathogenesis-related protein 1	266	30366	8.8	1	Membrane	NA	NA	NA	Belongs to the CRISP family.	PPARA activates gene expression;Neutrophil degranulation	PE1	12
+NX_P48061	Stromal cell-derived factor 1	93	10666	9.92	0	Secreted	NA	Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity).	Is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.;Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4.	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Axon guidance;Leukocyte transendothelial migration;Intestinal immune network for IgA production;Rheumatoid arthritis;G alpha (i) signalling events;Nuclear signaling by ERBB4;Chemokine receptors bind chemokines;Signaling by ROBO receptors;Estrogen-dependent gene expression	PE1	10
+NX_P48065	Sodium- and chloride-dependent betaine transporter	614	69368	5.96	12	Membrane;Cytoplasmic vesicle	NA	Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.	Amino acid transport across the plasma membrane;Na+/Cl- dependent neurotransmitter transporters;Creatine metabolism;Reuptake of GABA	PE1	12
+NX_P48066	Sodium- and chloride-dependent GABA transporter 3	632	70606	6.52	12	Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily.	GABAergic synapse;Na+/Cl- dependent neurotransmitter transporters;Creatine metabolism;Reuptake of GABA	PE1	3
+NX_P48067	Sodium- and chloride-dependent glycine transporter 1	706	78260	8.21	12	Membrane;Nucleoplasm;Golgi apparatus	Glycine encephalopathy with normal serum glycine	Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.	Na+/Cl- dependent neurotransmitter transporters	PE1	1
+NX_P48145	Neuropeptides B/W receptor type 1	328	36103	9.05	7	Cell membrane	NA	Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	8
+NX_P48146	Neuropeptides B/W receptor type 2	333	36861	9.35	7	Cell membrane	NA	Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	20
+NX_P48147	Prolyl endopeptidase	710	80700	5.53	0	Cytoplasm;Cytosol	NA	Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.	The N-terminus is blocked.	Belongs to the peptidase S9A family.	NA	PE1	6
+NX_P48163	NADP-dependent malic enzyme	572	64150	5.79	0	Nucleoplasm;Cytoplasm;Cytosol;Cell membrane	NA	NA	NA	Belongs to the malic enzymes family.	Pyruvate metabolism;Metabolic pathways;PPAR signaling pathway;PPARA activates gene expression;Pyruvate metabolism	PE1	6
+NX_P48165	Gap junction alpha-8 protein	433	48229	5.21	4	Gap junction;Cell membrane	Cataract 1, multiple types	Structural component of eye lens gap junctions (PubMed:18006672, PubMed:19756179). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:18006672, PubMed:19756179).	NA	Belongs to the connexin family. Alpha-type (group II) subfamily.	Gap junction assembly	PE1	1
+NX_P48167	Glycine receptor subunit beta	497	56122	9.03	4	Cytoplasm;Postsynaptic cell membrane;Cell membrane;Synapse;Dendrite	Hyperekplexia 2	Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub-subfamily.	Neuroactive ligand-receptor interaction;Neurotransmitter receptors and postsynaptic signal transmission	PE1	4
+NX_P48169	Gamma-aminobutyric acid receptor subunit alpha-4	554	61623	9.59	4	Cell membrane;Postsynaptic cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;GABA receptor activation	PE1	4
+NX_P48200	Iron-responsive element-binding protein 2	963	105059	6.62	0	Cytoplasm;Cytosol;Cell junction	Neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia	RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.	Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity.	Belongs to the aconitase/IPM isomerase family.	Iron uptake and transport	PE1	15
+NX_P48201	ATP synthase F(0) complex subunit C3, mitochondrial	142	14693	9.57	2	Mitochondrion membrane	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.	Trimethylated by ATPSCKMT at Lys-110. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.	Belongs to the ATPase C chain family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	2
+NX_P48230	Transmembrane 4 L6 family member 4	202	21396	4.91	4	Membrane;Cytosol;Cell membrane	NA	Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.	N-glycosylated. Glycosylation is required for the growth inhibitory effect.	Belongs to the L6 tetraspanin family.	NA	PE1	3
+NX_P48304	Lithostathine-1-beta	166	18665	5.67	0	Secreted	NA	Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.	All O-linked glycans consist of Gal-GlcNAc-Gal-GalNAc tetrasaccharide core and get elongated (microheterogeneity).	NA	NA	PE1	2
+NX_P48307	Tissue factor pathway inhibitor 2	235	26934	8.88	0	Secreted	NA	May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.	NA	NA	NA	PE1	7
+NX_P48357	Leptin receptor	1165	132494	6.09	1	Basolateral cell membrane;Secreted;Cell membrane	Leptin receptor deficiency	May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3.;Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.;Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).	On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. Phosphorylation of Tyr-1079 has a more accessory role.	Belongs to the type I cytokine receptor family. Type 2 subfamily.	Cytokine-cytokine receptor interaction;Neuroactive ligand-receptor interaction;Jak-STAT signaling pathway;Adipocytokine signaling pathway;Signaling by Leptin	PE1	1
+NX_P48378	DNA-binding protein RFX2	723	79987	6.29	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis-specific histone gene HIST1H1T (By similarity).	NA	Belongs to the RFX family.	NA	PE1	19
+NX_P48380	Transcription factor RFX3	749	83530	5.64	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430).	NA	Belongs to the RFX family.	NA	PE1	9
+NX_P48382	DNA-binding protein RFX5	616	65323	9.35	0	Nucleus	Bare lymphocyte syndrome 2	Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.	Phosphorylated.	Belongs to the RFX family.	Antigen processing and presentation;Tuberculosis;Primary immunodeficiency	PE1	1
+NX_P48426	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	406	46225	6.5	0	Golgi apparatus;Cytoplasm;Cell membrane;Cytosol;Nucleus	NA	Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.	NA	NA	Inositol phosphate metabolism;Phosphatidylinositol signaling system;Regulation of actin cytoskeleton;Synthesis of PIPs at the plasma membrane;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PI5P Regulates TP53 Acetylation;Synthesis of PIPs in the nucleus	PE1	10
+NX_P48431	Transcription factor SOX-2	317	34310	9.74	0	Nucleoplasm;Nucleus	Microphthalmia, syndromic, 3	Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).	Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.	NA	Transcriptional regulation of pluripotent stem cells;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;Deactivation of the beta-catenin transactivating complex;POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation;Interleukin-4 and Interleukin-13 signaling;Transcriptional Regulation by MECP2	PE1	3
+NX_P48436	Transcription factor SOX-9	509	56137	6.31	0	Nucleoplasm;Nucleus	46,XX sex reversal 2;Campomelic dysplasia;46,XY sex reversal 10	Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development (PubMed:24038782). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity).	Ubiquitinated. Ubiquitination leads to proteasomal degradation and is negatively regulated by DDRGK1.	NA	Deactivation of the beta-catenin transactivating complex;Transcriptional regulation by RUNX2	PE1	17
+NX_P48443	Retinoic acid receptor RXR-gamma	463	50871	7.55	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).	Acetylated by EP300.	Belongs to the nuclear hormone receptor family. NR2 subfamily.	PPAR signaling pathway;Adipocytokine signaling pathway;Pathways in cancer;Thyroid cancer;Small cell lung cancer;Non-small cell lung cancer;Nuclear Receptor transcription pathway;Signaling by Retinoic Acid	PE1	1
+NX_P48444	Coatomer subunit delta	511	57210	5.89	0	Golgi apparatus;Cytoplasm;COPI-coated vesicle membrane;Golgi apparatus membrane;Cytoplasmic vesicle	Short stature, rhizomelic, with microcephaly, micrognathia, and developmental delay	Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).	NA	Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	11
+NX_P48448	Aldehyde dehydrogenase family 3 member B2	385	42635	5.65	0	Lipid droplet	NA	Oxidizes medium and long chain aldehydes into non-toxic fatty acids.	Geranylgeranylation is important for localization to lipid droplets and enzyme activity.	Belongs to the aldehyde dehydrogenase family.	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.;Glycolysis / Gluconeogenesis;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;beta-Alanine metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways;Sphingolipid de novo biosynthesis	PE1	11
+NX_P48449	Lanosterol synthase	732	83309	6.16	0	Cytosol;Endoplasmic reticulum membrane	Hypotrichosis 14;Cataract 44	Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.	NA	Belongs to the terpene cyclase/mutase family.	Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.;Steroid biosynthesis;Metabolic pathways;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	21
+NX_P48454	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	512	58129	6.51	0	Cytoplasmic vesicle	NA	Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.	NA	Belongs to the PPP phosphatase family. PP-2B subfamily.	MAPK signaling pathway;Calcium signaling pathway;Oocyte meiosis;Apoptosis;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Osteoclast differentiation;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Long-term potentiation;Glutamatergic synapse;Dopaminergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Tuberculosis;HTLV-I infection;Activation of BAD and translocation to mitochondria;DARPP-32 events	PE1	8
+NX_P48506	Glutamate--cysteine ligase catalytic subunit	637	72766	5.74	0	Nucleoplasm;Cytosol;Nucleolus	Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency	NA	NA	Belongs to the glutamate--cysteine ligase type 3 family.	Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.;Glutathione metabolism;Metabolic pathways;Glutathione synthesis and recycling;Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)	PE1	6
+NX_P48507	Glutamate--cysteine ligase regulatory subunit	274	30727	5.7	0	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.	Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.;Glutathione metabolism;Metabolic pathways;Glutathione synthesis and recycling;Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)	PE1	1
+NX_P48509	CD151 antigen	253	28295	7.45	4	Membrane	Nephropathy with pretibial epidermolysis bullosa and deafness	(Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.;Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.	NA	Belongs to the tetraspanin (TM4SF) family.	Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly	PE1	11
+NX_P48539	Calmodulin regulator protein PCP4	62	6791	6.21	0	Nucleoplasm;Nucleolus	NA	Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls (PubMed:19106096, PubMed:23204517, PubMed:27876793). For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways (PubMed:21491429).	NA	Belongs to the PCP4 family.	NA	PE1	21
+NX_P48544	G protein-activated inward rectifier potassium channel 4	419	47668	5.24	2	Membrane	Hyperaldosteronism, familial, 3;Long QT syndrome 13	This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.	NA	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.	Dopaminergic synapse;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	PE1	11
+NX_P48546	Gastric inhibitory polypeptide receptor	466	53157	9.09	7	Cell membrane	NA	This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.	N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Glucagon-type ligand receptors	PE1	19
+NX_P48547	Potassium voltage-gated channel subfamily C member 1	511	57942	6.13	6	Presynaptic cell membrane;Cell membrane;Nucleus membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Axon	Epilepsy, progressive myoclonic 7	Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.	N-glycosylated; contains sialylated glycans.	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.	Voltage gated Potassium channels	PE1	11
+NX_P48549	G protein-activated inward rectifier potassium channel 1	501	56603	8.46	2	Membrane	NA	This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.	NA	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.	Glutamatergic synapse;Cholinergic synapse;Dopaminergic synapse;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	PE1	2
+NX_P48551	Interferon alpha/beta receptor 2	515	57759	4.37	1	Secreted;Cell membrane	Immunodeficiency 45	Is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).;Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569).;Are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950).	Glycosylated.;Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.	Belongs to the type II cytokine receptor family.	Cytokine-cytokine receptor interaction;Osteoclast differentiation;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Interferon alpha/beta signaling;Regulation of IFNA signaling	PE1	21
+NX_P48552	Nuclear receptor-interacting protein 1	1158	126942	8.36	0	Nucleolus;Nucleoplasm;Cytosol;Nucleus	Congenital anomalies of kidney and urinary tract 3	Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549).	Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.	NA	Circadian Clock;Estrogen-dependent gene expression;SUMOylation of transcription cofactors	PE1	21
+NX_P48553	Trafficking protein particle complex subunit 10	1259	142189	5.68	0	cis-Golgi network	NA	May play a role in vesicular transport from endoplasmic reticulum to Golgi.	NA	Belongs to the TMEM1 family.	COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs	PE1	21
+NX_P48556	26S proteasome non-ATPase regulatory subunit 8	350	39612	9.73	0	Golgi apparatus;Cytoplasm;Cytosol;Nucleus speckle	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.	NA	Belongs to the proteasome subunit S14 family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	19
+NX_P48594	Serpin B4	390	44854	5.86	0	Cytoplasm	NA	May act as a protease inhibitor to modulate the host immune response against tumor cells.	NA	Belongs to the serpin family. Ov-serpin subfamily.	Amoebiasis	PE1	18
+NX_P48595	Serpin B10	397	45403	5.8	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.	NA	Belongs to the serpin family. Ov-serpin subfamily.	Amoebiasis;Neutrophil degranulation	PE1	18
+NX_P48634	Protein PRRC2A	2157	228863	9.48	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	May play a role in the regulation of pre-mRNA splicing.	NA	NA	NA	PE1	6
+NX_P48637	Glutathione synthetase	474	52385	5.67	0	Nucleoplasm	Glutathione synthetase deficiency of erythrocytes;Glutathione synthetase deficiency	NA	NA	Belongs to the eukaryotic GSH synthase family.	Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.;Glutathione metabolism;Metabolic pathways;Glutathione synthesis and recycling;Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	PE1	20
+NX_P48643	T-complex protein 1 subunit epsilon	541	59671	5.45	0	Cytoplasm;Centrosome	Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).	NA	Belongs to the TCP-1 chaperonin family.	BBSome-mediated cargo-targeting to cilium;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	5
+NX_P48645	Neuromedin-U	174	19741	9.14	0	Secreted	NA	Neuromedin-U-25: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.;Neuromedin precursor-related peptide 36: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.;Neuromedin precursor-related peptide 33: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.	NA	Belongs to the NmU family.	G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	4
+NX_P48651	Phosphatidylserine synthase 1	473	55528	8.71	9	Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum membrane	Lenz-Majewski hyperostotic dwarfism	Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.	NA	Belongs to the phosphatidyl serine synthase family.	Phospholipid metabolism; phosphatidylserine biosynthesis.;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PS	PE1	8
+NX_P48664	Excitatory amino acid transporter 4	564	61565	9.26	8	Cell membrane;Cytoskeleton	NA	Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable).	NA	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A6 subfamily.	Glutamatergic synapse;Glutamate Neurotransmitter Release Cycle;Transport of inorganic cations/anions and amino acids/oligopeptides	PE1	19
+NX_P48668	Keratin, type II cytoskeletal 6C	564	60025	8.09	0	NA	Palmoplantar keratoderma, non-epidermolytic, focal or diffuse	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_P48681	Nestin	1621	177439	4.35	0	Cytoskeleton	NA	Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).	Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).	Belongs to the intermediate filament family.	NA	PE1	1
+NX_P48723	Heat shock 70 kDa protein 13	471	51927	5.52	0	Endoplasmic reticulum;Microsome	NA	Has peptide-independent ATPase activity.	NA	Belongs to the heat shock protein 70 family.	Regulation of HSF1-mediated heat shock response	PE1	21
+NX_P48728	Aminomethyltransferase, mitochondrial	403	43946	8.87	0	Nucleoplasm;Mitochondrion	Non-ketotic hyperglycinemia	The glycine cleavage system catalyzes the degradation of glycine.	NA	Belongs to the GcvT family.	Glycine, serine and threonine metabolism;One carbon pool by folate;Nitrogen metabolism;Metabolic pathways;Glycine degradation	PE1	3
+NX_P48729	Casein kinase I isoform alpha	337	38915	9.59	0	Cytoplasm;Nucleus speckle;Cilium basal body;Centrosome;Kinetochore	NA	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).	Autophosphorylated (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254)	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.	Wnt signaling pathway;Hedgehog signaling pathway;Degradation of beta-catenin by the destruction complex;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Activation of SMO;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex	PE1	5
+NX_P48730	Casein kinase I isoform delta	415	47330	9.77	0	Cytoplasm;Golgi apparatus;Cell membrane;Nucleolus;Nucleoplasm;Centrosome;Spindle;Perinuclear region;Nucleus	Advanced sleep phase syndrome, familial, 2	Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.	Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.	Hedgehog signaling pathway;Gap junction;Circadian rhythm - mammal;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Circadian Clock;Recruitment of NuMA to mitotic centrosomes;COPII-mediated vesicle transport;AURKA Activation by TPX2;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	17
+NX_P48735	Isocitrate dehydrogenase [NADP], mitochondrial	452	50909	8.88	0	Mitochondrion	Glioma;D-2-hydroxyglutaric aciduria 2	Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.	Acetylation at Lys-413 dramatically reduces catalytic activity. Deacetylated by SIRT3.	Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Citrate cycle (TCA cycle);Glutathione metabolism;Metabolic pathways;Peroxisome;Citric acid cycle (TCA cycle);Transcriptional activation of mitochondrial biogenesis	PE1	15
+NX_P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	1102	126454	7.23	0	Cytoplasm;Cytosol;Cell membrane	NA	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.	NA	Belongs to the PI3/PI4-kinase family.	Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.;Inositol phosphate metabolism;ErbB signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;mTOR signaling pathway;Apoptosis;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Cholinergic synapse;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Carbohydrate digestion and absorption;Bacterial invasion of epithelial cells;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Acute myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Synthesis of PIPs at the plasma membrane;GPVI-mediated activation cascade;G beta:gamma signalling through PI3Kgamma;Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	PE1	7
+NX_P48739	Phosphatidylinositol transfer protein beta isoform	271	31540	6.41	0	Golgi apparatus;Cytoplasm	NA	Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.	Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.	Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.	PI and PC transport between ER and Golgi membranes	PE1	22
+NX_P48740	Mannan-binding lectin serine protease 1	699	79247	5.29	0	Nucleoplasm;Cytosol;Secreted	3MC syndrome 1	May have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343).;Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction.	N-glycosylated. Some N-linked glycan are of the complex-type (By similarity).;But not isoform 2 is activated through autoproteolytic processing.;Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond.;The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.	Belongs to the peptidase S1 family.	Complement and coagulation cascades;Staphylococcus aureus infection;Scavenging by Class A Receptors;Initial triggering of complement;Lectin pathway of complement activation;Ficolins bind to repetitive carbohydrate structures on the target cell surface	PE1	3
+NX_P48741	Putative heat shock 70 kDa protein 7	367	40244	7.72	0	NA	NA	NA	NA	Belongs to the heat shock protein 70 family.	Regulation of HSF1-mediated heat shock response	PE5	1
+NX_P48742	LIM/homeobox protein Lhx1	406	44808	7.86	0	Nucleus;Golgi apparatus;Nucleoplasm;Nucleus membrane	NA	Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.	NA	NA	NA	PE1	17
+NX_P48745	CCN family member 3	357	39162	8.12	0	Cytoplasm;Gap junction;Secreted;Cytoplasmic vesicle	NA	Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891).	May be palmitoylated on Cys-244, which is important for extracellular secretion.	Belongs to the CCN family.	NA	PE1	8
+NX_P48751	Anion exchange protein 3	1232	135791	6.01	10	Membrane;Nucleoplasm	NA	Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-).	NA	Belongs to the anion exchanger (TC 2.A.31) family.	Bicarbonate transporters	PE1	2
+NX_P48764	Sodium/hydrogen exchanger 3	834	92855	7.05	10	Apical cell membrane;Cell membrane	Diarrhea 8, secretory sodium, congenital	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.	Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Proximal tubule bicarbonate reclamation;Protein digestion and absorption;Bile secretion;Mineral absorption;Sodium/Proton exchangers	PE1	5
+NX_P48775	Tryptophan 2,3-dioxygenase	406	47872	6.46	0	Cytosol;Cell membrane	Hypertryptophanemia	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	NA	Belongs to the tryptophan 2,3-dioxygenase family.	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.;Tryptophan metabolism;Metabolic pathways;Tryptophan catabolism	PE1	4
+NX_P48788	Troponin I, fast skeletal muscle	182	21339	8.87	0	Cell membrane;Cytoskeleton	Arthrogryposis, distal, 2B1	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	NA	Belongs to the troponin I family.	Striated Muscle Contraction	PE1	11
+NX_P48960	CD97 antigen	835	91869	6.5	7	Cytosol;Extracellular space;Cell membrane	NA	Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).	Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.	Class B/2 (Secretin family receptors);Neutrophil degranulation	PE1	19
+NX_P48995	Short transient receptor potential channel 1	793	91212	8.33	6	Membrane;Cytoplasmic vesicle	NA	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.	Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.	Calcium signaling pathway;Glutamatergic synapse;Pancreatic secretion;TRP channels;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of second messengers in netrin-1 signaling;Ion homeostasis	PE1	3
+NX_P49005	DNA polymerase delta subunit 2	469	51289	5.35	0	Nucleoplasm;Nucleus	NA	As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the POLZ complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).	NA	Belongs to the DNA polymerase delta/II small subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination;HTLV-I infection;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Termination of translesion DNA synthesis;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Polymerase switching on the C-strand of the telomere;Processive synthesis on the C-strand of the telomere;Telomere C-strand (Lagging Strand) Synthesis;Removal of the Flap Intermediate from the C-strand;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER	PE1	7
+NX_P49006	MARCKS-related protein	195	19529	4.68	0	Nucleoplasm;Cytosol;Cytoskeleton;Cell membrane	NA	Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).	Phosphorylated. Phosphorylation at Ser-120 and Thr-178 is non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8. May be phosphorylated by protein kinase C, which disrupts the interaction with calmodulin.	Belongs to the MARCKS family.	Fc gamma R-mediated phagocytosis;Leishmaniasis	PE1	1
+NX_P49019	Hydroxycarboxylic acid receptor 3	387	44478	9.09	7	Cell membrane	NA	Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Hydroxycarboxylic acid-binding receptors	PE1	12
+NX_P49023	Paxillin	591	64505	5.8	0	Cell cortex;Focal adhesion;Centrosome;Cytosol;Cytoskeleton	NA	Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).	Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389).;PXN is phosphorylated by LYN (Phosphotyrosine:PTM-0255);PXN is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	Belongs to the paxillin family.	Chemokine signaling pathway;VEGF signaling pathway;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;GAB1 signalosome;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	PE1	12
+NX_P49069	Calcium signal-modulating cyclophilin ligand	296	32953	8.2	2	Membrane;Nucleoplasm;Nucleolus;Cytoplasmic vesicle	NA	Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.	NA	NA	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	5
+NX_P49116	Nuclear receptor subfamily 2 group C member 2	596	65414	5.89	0	Nucleoplasm;Nucleus	NA	Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.	Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the non-phosphorylated form preferentially recruits the coactivator, PCAF (By similarity).	Belongs to the nuclear hormone receptor family. NR2 subfamily.	Nuclear Receptor transcription pathway	PE1	3
+NX_P49137	MAP kinase-activated protein kinase 2	400	45568	8.87	0	Nucleoplasm;Cytoplasm;Centrosome;Nucleus	NA	Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.	Sumoylation inhibits the protein kinase activity.;Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-222, Ser-272 and Thr-334.;MAPKAPK2 is phosphorylated by MAPK11 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	MAPK signaling pathway;VEGF signaling pathway;Neurotrophin signaling pathway;Regulation of HSF1-mediated heat shock response;Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;VEGFA-VEGFR2 Pathway;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;p38MAPK events;Synthesis of Leukotrienes (LT) and Eoxins (EX);CREB phosphorylation	PE1	1
+NX_P49146	Neuropeptide Y receptor type 2	381	42731	6.79	7	Cell membrane	NA	Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	4
+NX_P49184	Deoxyribonuclease-1-like 1	302	33893	5.45	0	Endoplasmic reticulum	NA	NA	NA	Belongs to the DNase I family.	Neutrophil degranulation	PE1	X
+NX_P49189	4-trimethylaminobutyraldehyde dehydrogenase	494	53802	5.69	0	Cytosol	NA	Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.	NA	Belongs to the aldehyde dehydrogenase family.	Amine and polyamine biosynthesis; carnitine biosynthesis.;Glycolysis / Gluconeogenesis;Ascorbate and aldarate metabolism;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Lysine degradation;Arginine and proline metabolism;Histidine metabolism;Tryptophan metabolism;beta-Alanine metabolism;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Carnitine synthesis	PE1	1
+NX_P49190	Parathyroid hormone 2 receptor	550	62236	6.65	7	Cell membrane	NA	This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).	NA	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Class B/2 (Secretin family receptors)	PE1	2
+NX_P49207	60S ribosomal protein L34	117	13293	11.48	0	Endoplasmic reticulum;Cytoplasm;Cytosol;Nucleolus	NA	Component of the large ribosomal subunit.	NA	Belongs to the eukaryotic ribosomal protein eL34 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	4
+NX_P49221	Protein-glutamine gamma-glutamyltransferase 4	684	77145	6.31	0	NA	NA	Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.	NA	Belongs to the transglutaminase superfamily. Transglutaminase family.	NA	PE1	3
+NX_P49223	Kunitz-type protease inhibitor 3	89	10252	6.21	0	Secreted	NA	NA	NA	NA	NA	PE1	20
+NX_P49238	CX3C chemokine receptor 1	355	40396	6.74	7	Cell membrane	Macular degeneration, age-related, 12	Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro) (PubMed:9726990).;Seem to be more potent HIV-1 coreceptors than isoform 1 (PubMed:14607932).	This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	3
+NX_P49247	Ribose-5-phosphate isomerase	311	33269	8.78	0	Cytoplasmic vesicle;Nucleoplasm;Cell membrane	Ribose 5-phosphate isomerase deficiency	NA	NA	Belongs to the ribose 5-phosphate isomerase family.	Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.;Pentose phosphate pathway;Metabolic pathways;Pentose phosphate pathway;RPIA deficiency: failed conversion of R5P to RU5P;RPIA deficiency: failed conversion of RU5P to R5P	PE1	2
+NX_P49257	Protein ERGIC-53	510	57549	6.3	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;Cytosol;Endoplasmic reticulum membrane;Golgi apparatus membrane	Factor V and factor VIII combined deficiency 1	Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.	The N-terminal may be partly blocked.	NA	Protein processing in endoplasmic reticulum;COPII-mediated vesicle transport;Transport to the Golgi and subsequent modification;Cargo concentration in the ER	PE1	18
+NX_P49279	Natural resistance-associated macrophage protein 1	550	59872	7.58	12	Membrane	NA	Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.	NA	Belongs to the NRAMP family.	Lysosome;Mineral absorption;ROS and RNS production in phagocytes;Metal ion SLC transporters;Neutrophil degranulation;Ion influx/efflux at host-pathogen interface	PE1	2
+NX_P49281	Natural resistance-associated macrophage protein 2	568	62266	5.72	12	Mitochondrion outer membrane;Mitochondrion;Cell membrane;Endosome membrane;Early endosome	Anemia, hypochromic microcytic, with iron overload 1	Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.	N-glycosylated.;Ubiquitinated by WWP2.	Belongs to the NRAMP family.	Lysosome;Mineral absorption;Iron uptake and transport;Metal ion SLC transporters;Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)	PE1	12
+NX_P49286	Melatonin receptor type 1B	362	40188	9.12	7	Cell membrane	NA	High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Class A/1 (Rhodopsin-like receptors)	PE1	11
+NX_P49321	Nuclear autoantigenic sperm protein	788	85238	4.26	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.	NA	Belongs to the NASP family.	NA	PE1	1
+NX_P49326	Dimethylaniline monooxygenase [N-oxide-forming] 5	533	60221	8.41	1	Microsome membrane;Endoplasmic reticulum;Cytosol;Endoplasmic reticulum membrane	NA	In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.	NA	Belongs to the FMO family.	Drug metabolism - cytochrome P450	PE1	1
+NX_P49327	Fatty acid synthase	2511	273427	6.01	0	Cytoplasm;Cytosol;Melanosome;Cell membrane	NA	Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	FASN is phosphorylated by MAPK3	NA	Fatty acid biosynthesis;Metabolic pathways;Insulin signaling pathway;ChREBP activates metabolic gene expression;Activation of gene expression by SREBF (SREBP);Fatty acyl-CoA biosynthesis;Vitamin B5 (pantothenate) metabolism	PE1	17
+NX_P49335	POU domain, class 3, transcription factor 4	361	39427	7.07	0	Nucleoplasm;Nucleus	Deafness, X-linked, 2	Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.	NA	Belongs to the POU transcription factor family. Class-3 subfamily.	NA	PE1	X
+NX_P49336	Cyclin-dependent kinase 8	464	53284	8.72	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Generic Transcription Pathway;PPARA activates gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Transcriptional regulation of white adipocyte differentiation	PE1	13
+NX_P49354	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	379	44409	4.96	0	Cytosol	NA	Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.	Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).;FNTA is phosphorylated by TGFBR1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein prenyltransferase subunit alpha family.	Inactivation, recovery and regulation of the phototransduction cascade;Apoptotic cleavage of cellular proteins	PE1	8
+NX_P49356	Protein farnesyltransferase subunit beta	437	48774	5.51	0	Centrosome	NA	Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.	NA	Belongs to the protein prenyltransferase subunit beta family.	Inactivation, recovery and regulation of the phototransduction cascade	PE1	14
+NX_P49366	Deoxyhypusine synthase	369	40971	5.22	0	Nucleoplasm;Cytosol;Cell membrane	NA	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.	NA	Belongs to the deoxyhypusine synthase family.	Protein modification; eIF5A hypusination.;Hypusine synthesis from eIF5A-lysine	PE1	19
+NX_P49368	T-complex protein 1 subunit gamma	545	60534	6.1	0	Cytoplasm;Cytosol;Cell membrane	NA	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).	NA	Belongs to the TCP-1 chaperonin family.	BBSome-mediated cargo-targeting to cilium;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	1
+NX_P49406	39S ribosomal protein L19, mitochondrial	292	33535	9.55	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bL19 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	2
+NX_P49407	Beta-arrestin-1	418	47066	5.84	0	Cytoplasm;Cell membrane;Clathrin-coated pit;Nucleoplasm;Pseudopodium;Cytoplasmic vesicle;Nucleus	NA	Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3. Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates to the recruitment of the ubiquitin-protein ligase to the receptor (PubMed:23886940).	The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and signaling. Ubiquitination appears to occur GPCR-specific. Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and subsequently promotes association with USP33.;Constitutively phosphorylated at Ser-412 in the cytoplasm. At the plasma membrane, is rapidly dephosphorylated, a process that is required for clathrin binding and ADRB2 endocytosis but not for ADRB2 binding and desensitization. Once internalized, is rephosphorylated.	Belongs to the arrestin family.	MAPK signaling pathway;Chemokine signaling pathway;Endocytosis;Phototransduction;G alpha (s) signalling events;Activation of SMO;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;MAP2K and MAPK activation;Thrombin signalling through proteinase activated receptors (PARs);Activated NOTCH1 Transmits Signal to the Nucleus;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	11
+NX_P49411	Elongation factor Tu, mitochondrial	452	49542	7.26	0	Mitochondrion	Combined oxidative phosphorylation deficiency 4	Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Mitochondrial translation elongation	PE1	16
+NX_P49418	Amphiphysin	695	76257	4.58	0	Cytosol;Synaptic vesicle membrane;Cell membrane;Cytoskeleton	NA	May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.	NA	NA	Fc gamma R-mediated phagocytosis;Clathrin-mediated endocytosis	PE1	7
+NX_P49419	Alpha-aminoadipic semialdehyde dehydrogenase	539	58487	8.21	0	Cytosol;Mitochondrion;Nucleus	Pyridoxine-dependent epilepsy	Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.	NA	Belongs to the aldehyde dehydrogenase family.	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.;Glycolysis / Gluconeogenesis;Ascorbate and aldarate metabolism;Fatty acid metabolism;Glycine, serine and threonine metabolism;Valine, leucine and isoleucine degradation;Lysine biosynthesis;Lysine degradation;Arginine and proline metabolism;Histidine metabolism;Tryptophan metabolism;beta-Alanine metabolism;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Lysine catabolism;Choline catabolism	PE1	5
+NX_P49427	Ubiquitin-conjugating enzyme E2 R1	236	26737	4.41	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:10329681, PubMed:10373550, PubMed:10871850, PubMed:11675391, PubMed:12037680, PubMed:15652359, PubMed:17461777, PubMed:17698585, PubMed:19112177, PubMed:19126550, PubMed:19945379, PubMed:20061386, PubMed:20347421).	Phosphorylated by CK2. Phosphorylation of the C-terminal tail by CK2 controles the nuclear localization.;Autoubiquitinated (PubMed:22496338, PubMed:11805320, PubMed:12060736). Autoubiquitination is promoted by the human herpes virus 1 protein ICP0 and leads to degradation by the Ubiquitin-proteasomal pathway (PubMed:11805320, PubMed:12060736).	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Herpes simplex infection;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	19
+NX_P49441	Inositol polyphosphate 1-phosphatase	399	43998	5.15	0	Cytosol;Centriolar satellite	NA	NA	NA	Belongs to the inositol monophosphatase superfamily.	Signal transduction; phosphatidylinositol signaling pathway.;Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of IP2, IP, and Ins in the cytosol	PE1	2
+NX_P49447	Cytochrome b561	251	27559	8.73	6	Secretory vesicle membrane	Orthostatic hypotension 2	Secretory vesicle-specific electron transport protein.	NA	NA	NA	PE1	17
+NX_P49448	Glutamate dehydrogenase 2, mitochondrial	558	61434	8.63	0	Mitochondrion matrix	NA	Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.	Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.	Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;D-Glutamine and D-glutamate metabolism;Nitrogen metabolism;Metabolic pathways;Proximal tubule bicarbonate reclamation;Transcriptional activation of mitochondrial biogenesis;Glutamate and glutamine metabolism	PE1	X
+NX_P49450	Histone H3-like centromeric protein A	140	15991	11.71	0	Kinetochore;Nucleoplasm;Centromere;Nucleus	NA	Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292).	Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway.;Phosphorylated by CDK1 at Ser-68 during early mitosis; this abolishes association with chromatin and centromeres, prevents interaction with HJURP and thereby prevents premature assembly of CENPA into centromeres (PubMed:25556658). Dephosphorylated at Ser-68 by PPP1CA during late mitosis (PubMed:25556658). Phosphorylation of Ser-7 by AURKA and AURKB during prophase is required for localization of AURKA and AURKB at inner centromere and is essential for normal cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18239465). Initial phosphorylation during prophase is mediated by AURKA and is maintained by AURKB.;Poly-ADP-ribosylated by PARP1.;Trimethylated by NTMT1 at the N-terminal glycine after cleavage of Met-1. Methylation is low before incorporation into nucleosomes and increases with cell cycle progression, with the highest levels in mitotic nucleosomes.	Belongs to the histone H3 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	2
+NX_P49454	Centromere protein F	3114	357527	5.06	0	Nucleus matrix;Nucleoplasm;Spindle;Perinuclear region;Kinetochore	Stromme syndrome	Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.	Hyperphosphorylated during mitosis.	Belongs to the centromere protein F family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Polo-like kinase mediated events;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	1
+NX_P49458	Signal recognition particle 9 kDa protein	86	10112	7.76	0	Cytoplasm	NA	Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.	NA	Belongs to the SRP9 family.	Protein export;SRP-dependent cotranslational protein targeting to membrane	PE1	1
+NX_P49459	Ubiquitin-conjugating enzyme E2 A	152	17315	5.06	0	NA	Mental retardation, X-linked, syndromic, Nascimento-type	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.	Phosphorylation at Ser-120 by CDK9 increases activity towards histone H2B.;UBE2A is phosphorylated by CDK1	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins	PE1	X
+NX_P49585	Choline-phosphate cytidylyltransferase A	367	41731	6.82	0	Membrane;Nucleoplasm;Cytosol	Spondylometaphyseal dysplasia with cone-rod dystrophy	Controls phosphatidylcholine synthesis.	The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation (By similarity).;Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.	Belongs to the cytidylyltransferase family.	Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PC	PE1	3
+NX_P49588	Alanine--tRNA ligase, cytoplasmic	968	106810	5.34	0	Cytoplasm;Cytosol	Epileptic encephalopathy, early infantile, 29;Charcot-Marie-Tooth disease 2N	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438).	ISGylated.	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation	PE1	16
+NX_P49589	Cysteine--tRNA ligase, cytoplasmic	748	85473	6.31	0	Cytoplasm;Cytosol	NA	NA	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation	PE1	11
+NX_P49590	Probable histidine--tRNA ligase, mitochondrial	506	56888	8.53	0	Mitochondrion matrix;Cytosol	Perrault syndrome 2	NA	NA	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	5
+NX_P49591	Serine--tRNA ligase, cytoplasmic	514	58777	6.05	0	Cytoplasm;Cytosol;Nucleus	Neurodevelopmental disorder with microcephaly, ataxia, and seizures	Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).	NA	Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.	Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.;Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation;Selenocysteine synthesis	PE1	1
+NX_P49593	Protein phosphatase 1F	454	49831	4.99	0	Nucleoplasm;Cell membrane	NA	Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.	NA	Belongs to the PP2C family.	Negative regulation of NMDA receptor-mediated neuronal transmission	PE1	22
+NX_P49619	Diacylglycerol kinase gamma	791	89124	6.36	0	Membrane;Cytoplasm;Cytoplasmic vesicle;Cell membrane	NA	Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.	NA	Belongs to the eukaryotic diacylglycerol kinase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Effects of PIP2 hydrolysis	PE1	3
+NX_P49638	Alpha-tocopherol transfer protein	278	31750	7.17	0	Cytoplasm	Ataxia with isolated vitamin E deficiency	Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity).	NA	NA	Vitamin E	PE1	8
+NX_P49639	Homeobox protein Hox-A1	335	36641	8.13	0	Nucleus	Athabaskan brainstem dysgenesis syndrome;Bosley-Salih-Alorainy syndrome	Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity).	NA	Belongs to the Antp homeobox family. Labial subfamily.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	7
+NX_P49640	Homeobox even-skipped homolog protein 1	407	42440	6.41	0	Nucleoplasm;Nucleus	NA	May play a role in the specification of neuronal cell types.	NA	Belongs to the even-skipped homeobox family.	NA	PE2	7
+NX_P49641	Alpha-mannosidase 2x	1150	130539	6.35	1	Cytosol;Golgi apparatus membrane	NA	Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.	NA	Belongs to the glycosyl hydrolase 38 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Reactions specific to the complex N-glycan synthesis pathway;Intra-Golgi traffic	PE1	15
+NX_P49642	DNA primase small subunit	420	49902	8.39	0	Cytoplasmic vesicle	NA	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.	NA	Belongs to the eukaryotic-type primase small subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Activation of the pre-replicative complex;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;Telomere C-strand synthesis initiation;DNA replication initiation	PE1	12
+NX_P49643	DNA primase large subunit	509	58806	7.97	0	Nucleoplasm	NA	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.	NA	Belongs to the eukaryotic-type primase large subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Activation of the pre-replicative complex;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;Telomere C-strand synthesis initiation;DNA replication initiation	PE1	6
+NX_P49662	Caspase-4	377	43262	5.69	0	Endoplasmic reticulum membrane;Mitochondrion;Inflammasome;Cell membrane;Secreted;Cytosol	NA	Inflammatory caspase (PubMed:7797510, PubMed:23516580, PubMed:25119034). Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS (PubMed:22246630, PubMed:26174085, PubMed:26173988, PubMed:26508369, PubMed:25964352). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:24879791, PubMed:25964352). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection (PubMed:25121752). In later stages of the infection, LPS from cytosolic Salmonella triggers CASP4 activation, which ultimately results in pyroptosis of infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation. Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found Alzheimer's patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Activated by direct binding to LPS without the need of an upstream sensor (PubMed:25119034). Does not directly process IL1B (PubMed:7743998, PubMed:7797592, PubMed:7797510). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).	In response to activation signals, including endoplasmic reticulum stress or treatment with amyloid-beta A4 protein fragments (such as amyloid-beta protein 40), undergoes autoproteolytic cleavage.	Belongs to the peptidase C14A family.	NOD1/2 Signaling Pathway	PE1	11
+NX_P49674	Casein kinase I isoform epsilon	416	47315	9.68	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.	Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.	Wnt signaling pathway;Hedgehog signaling pathway;Circadian rhythm - mammal;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Circadian Clock;Recruitment of NuMA to mitotic centrosomes;WNT mediated activation of DVL;AURKA Activation by TPX2;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	22
+NX_P49675	Steroidogenic acute regulatory protein, mitochondrial	285	31914	9.17	0	Mitochondrion	Adrenal hyperplasia 1	Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.	NA	NA	Steroid metabolism; cholesterol metabolism.;Pregnenolone biosynthesis	PE1	8
+NX_P49682	C-X-C chemokine receptor type 3	368	40660	7.92	7	Cell membrane	NA	Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.;Mediates the activity of CXCL11.;Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.	Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.;N-glycosylated.	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	X
+NX_P49683	Prolactin-releasing peptide receptor	370	41121	9.43	7	Cell membrane	NA	Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors	PE1	10
+NX_P49685	G-protein coupled receptor 15	360	40787	9.01	7	Cell membrane	NA	Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (s) signalling events	PE1	3
+NX_P49703	ADP-ribosylation factor-like protein 4D	201	22156	9.94	0	Golgi apparatus;Cytoplasm;Cell membrane;Nucleolus;Cytoplasmic vesicle;Nucleus	NA	Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	17
+NX_P49711	Transcriptional repressor CTCF	727	82785	6.51	0	Nucleoplasm;Centromere;Chromosome	Mental retardation, autosomal dominant 21	Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays an important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X- inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19. Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640).	Sumoylated on Lys-74 and Lys-689; sumoylation of CTCF contributes to the repressive function of CTCF on the MYC P2 promoter.	Belongs to the CTCF zinc-finger protein family.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	16
+NX_P49715	CCAAT/enhancer-binding protein alpha	358	37561	7.27	0	Nucleoplasm;Nucleolus;Nucleus;Cytoplasmic vesicle	Leukemia, acute myelogenous	Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation (PubMed:14660596).;Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation.;Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity).	Ubiquitinated by COP1 upon interaction with TRIB1.;Sumoylated, sumoylation blocks the inhibitory effect on cell proliferation by disrupting the interaction with SMARCA2.;Phosphorylation at Ser-190 is required for interaction with CDK2, CDK4 and SWI/SNF complex leading to cell cycle inhibition. Dephosphorylated at Ser-190 by protein phosphatase 2A (PP2A) through PI3K/AKT signaling pathway regulation (PubMed:15107404). Phosphorylation at Thr-226 and Thr-230 by GSK3 is constitutive in adipose tissue and lung. In liver, both Thr-226 and Thr-230 are phosphorylated only during feeding but not during fasting. Phosphorylation of the GSK3 consensus sites selectively decreases transactivation activity on IRE-controlled promoters.	Belongs to the bZIP family. C/EBP subfamily.	Pathways in cancer;Acute myeloid leukemia;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of granulopoiesis	PE1	19
+NX_P49716	CCAAT/enhancer-binding protein delta	269	28467	8.44	0	Nucleoplasm;Nucleus	NA	Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).	NA	Belongs to the bZIP family. C/EBP subfamily.	Transcriptional regulation of white adipocyte differentiation;Interleukin-4 and Interleukin-13 signaling	PE1	8
+NX_P49720	Proteasome subunit beta type-3	205	22949	6.14	0	Cytoplasm;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).	NA	Belongs to the peptidase T1B family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	17
+NX_P49721	Proteasome subunit beta type-2	201	22836	6.52	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).	NA	Belongs to the peptidase T1B family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	1
+NX_P49736	DNA replication licensing factor MCM2	904	101896	5.34	0	Nucleoplasm;Nucleus	Deafness, autosomal dominant, 70	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis.	Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. Phosphorylation by the CDC7-DBF4 complex during G1/S phase is required for the initiation of DNA replication.	Belongs to the MCM family.	DNA replication;Cell cycle;Orc1 removal from chromatin;Activation of ATR in response to replication stress;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;Unwinding of DNA;Switching of origins to a post-replicative state	PE1	3
+NX_P49746	Thrombospondin-3	956	104201	4.43	0	Cytoplasmic vesicle	NA	Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.	NA	Belongs to the thrombospondin family.	Phagosome;TGF-beta signaling pathway;Focal adhesion;ECM-receptor interaction;Malaria;Signaling by PDGF	PE1	1
+NX_P49747	Cartilage oligomeric matrix protein	757	82860	4.36	0	Golgi apparatus;Extracellular matrix	Pseudoachondroplasia;Multiple epiphyseal dysplasia 1	May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).	NA	Belongs to the thrombospondin family.	Phagosome;TGF-beta signaling pathway;Focal adhesion;ECM-receptor interaction;Malaria;Integrin cell surface interactions;ECM proteoglycans	PE1	19
+NX_P49748	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	655	70390	8.92	0	Mitochondrion;Nucleolus;Nucleoplasm;Cytosol;Mitochondrion inner membrane	Acyl-CoA dehydrogenase very long-chain deficiency	Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons.	S-nitrosylation at Cys-237 in liver improves catalytic efficiency.	Belongs to the acyl-CoA dehydrogenase family.	Lipid metabolism; mitochondrial fatty acid beta-oxidation.;Fatty acid metabolism;Metabolic pathways;XBP1(S) activates chaperone genes;Beta oxidation of palmitoyl-CoA to myristoyl-CoA	PE1	17
+NX_P49750	YLP motif-containing protein 1	2146	241645	6.12	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.	NA	NA	NA	PE1	14
+NX_P49753	Acyl-coenzyme A thioesterase 2, mitochondrial	483	53218	8.7	0	Mitochondrion	NA	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:16940157, PubMed:10944470). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity).	NA	Belongs to the C/M/P thioester hydrolase family.	Lipid metabolism; fatty acid metabolism.;Fatty acid elongation;Biosynthesis of unsaturated fatty acids;Mitochondrial Fatty Acid Beta-Oxidation;Peroxisomal protein import	PE1	14
+NX_P49754	Vacuolar protein sorting-associated protein 41 homolog	854	98566	5.56	0	trans-Golgi network;Clathrin-coated vesicle;Endosome membrane;Early endosome;Late endosome;Lysosome	NA	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660).	NA	Belongs to the VPS41 family.	NA	PE1	7
+NX_P49755	Transmembrane emp24 domain-containing protein 10	219	24976	6.98	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi apparatus;Endoplasmic reticulum membrane;Cell membrane;trans-Golgi network membrane;cis-Golgi network membrane;Secretory vesicle membrane;Melanosome	NA	Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.	NA	Belongs to the EMP24/GP25L family.	COPII-mediated vesicle transport;Cargo concentration in the ER;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	14
+NX_P49756	RNA-binding protein 25	843	100185	6.06	0	Cytoplasm;Nucleus speckle	NA	RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.	Sumoylated.	NA	Spliceosome	PE1	14
+NX_P49757	Protein numb homolog	651	70804	8.79	0	Membrane;Cell junction	NA	Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.	Are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.;Phosphorylated on Ser-276 and Ser-295 by CaMK1.;NUMB is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Notch signaling pathway;Degradation of GLI1 by the proteasome;Hedgehog 'on' state;Recycling pathway of L1;Activated NOTCH1 Transmits Signal to the Nucleus	PE1	14
+NX_P49758	Regulator of G-protein signaling 6	472	54423	7.05	0	Cytoplasm;Cell membrane;Nucleolus;Membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509).	NA	NA	G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	14
+NX_P49759	Dual specificity protein kinase CLK1	484	57291	9.05	0	Nucleoplasm;Nucleus;Nucleus membrane	NA	Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.	Autophosphorylates on all three types of residues.;Autophosphorylated (Phosphotyrosine:PTM-0255);CLK1 is phosphorylated by AKT2 (Phosphoserine,Phosphotyrosine:PTM-0253,PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.	Legionellosis	PE1	2
+NX_P49760	Dual specificity protein kinase CLK2	499	60090	9.69	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210).	Autophosphorylates on all three types of residues. Phosphorylation on Ser-34 and Thr-127 by AKT1 is induced by ionizing radiation or insulin. Phosphorylation plays a critical role in cell proliferation following low dose radiation and prevents cell death following high dose radiation. Phosphorylation at Thr-344 by PKB/AKT2 induces its kinase activity which is required for its stability. The phosphorylation status at Ser-142 influences its subnuclear localization; inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.	NA	PE1	1
+NX_P49761	Dual specificity protein kinase CLK3	638	73515	9.94	0	Cytoplasm;Nucleus speckle;Acrosome;Nucleoplasm;Nucleus;Cytoskeleton	NA	Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.	Autophosphorylates on all three types of residues.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.	NA	PE1	15
+NX_P49763	Placenta growth factor	221	24789	8.52	0	Nucleoplasm;Cytosol;Mitochondrion;Secreted	NA	Binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.;Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1.	N-glycosylated.	Belongs to the PDGF/VEGF growth factor family.	mTOR signaling pathway;Focal adhesion;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Bladder cancer;Rheumatoid arthritis;VEGF ligand-receptor interactions;VEGF binds to VEGFR leading to receptor dimerization	PE1	14
+NX_P49765	Vascular endothelial growth factor B	207	21602	8.46	0	Secreted	NA	Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.	VEGF-B186 is O-glycosylated.	Belongs to the PDGF/VEGF growth factor family.	Cytokine-cytokine receptor interaction;mTOR signaling pathway;Focal adhesion;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Bladder cancer;Rheumatoid arthritis;Platelet degranulation;VEGF ligand-receptor interactions;VEGF binds to VEGFR leading to receptor dimerization	PE1	11
+NX_P49767	Vascular endothelial growth factor C	419	46883	7.77	0	Secreted	Lymphatic malformation 4	Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.	Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.	Belongs to the PDGF/VEGF growth factor family.	Cytokine-cytokine receptor interaction;mTOR signaling pathway;Focal adhesion;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;Bladder cancer;Platelet degranulation;VEGF ligand-receptor interactions;VEGF binds to VEGFR leading to receptor dimerization	PE1	4
+NX_P49768	Presenilin-1	467	52668	5.18	9	Golgi apparatus;Endoplasmic reticulum membrane;Cell membrane;Early endosome;Growth cone;Cell junction;Nucleoplasm;Endoplasmic reticulum;Synapse;Golgi apparatus membrane;Early endosome membrane;Neuron projection;Axon;Cytoplasmic granule	Pick disease of the brain;Frontotemporal dementia;Cardiomyopathy, dilated 1U;Alzheimer disease 3;Acne inversa, familial, 3	Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15274632, PubMed:10545183, PubMed:10593990, PubMed:10206644, PubMed:10899933, PubMed:10811883, PubMed:12679784, PubMed:12740439, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874, PubMed:28269784, PubMed:20460383). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:9738936, PubMed:10593990, PubMed:10899933, PubMed:10811883). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:9738936, PubMed:11953314). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:25394380, PubMed:16959576). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity).	Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by caspase-3 to produce the fragment, PS1-CTF12.;After endoproteolysis, the C-terminal fragment (CTF) is phosphorylated on serine residues by PKA and/or PKC. Phosphorylation on Ser-346 inhibits endoproteolysis.	Belongs to the peptidase A22A family.	Wnt signaling pathway;Notch signaling pathway;Neurotrophin signaling pathway;Alzheimer's disease;Degradation of the extracellular matrix;EPH-ephrin mediated repulsion of cells;Nuclear signaling by ERBB4;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Regulated proteolysis of p75NTR;NOTCH2 Activation and Transmission of Signal to the Nucleus;NRIF signals cell death from the nucleus;Neutrophil degranulation;NOTCH3 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3;NOTCH4 Activation and Transmission of Signal to the Nucleus	PE1	14
+NX_P49770	Translation initiation factor eIF-2B subunit beta	351	38990	5.77	0	Nucleoplasm;Focal adhesion;Cell membrane	Leukodystrophy with vanishing white matter	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.	NA	Belongs to the eIF-2B alpha/beta/delta subunits family.	RNA transport;Recycling of eIF2:GDP	PE1	14
+NX_P49771	Fms-related tyrosine kinase 3 ligand	235	26416	7.6	1	Secreted;Cell membrane	NA	Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.	NA	NA	Cytokine-cytokine receptor interaction;Hematopoietic cell lineage;Pathways in cancer;RAF/MAP kinase cascade;PI3K Cascade;FLT3 Signaling;STAT5 Activation	PE1	19
+NX_P49773	Histidine triad nucleotide-binding protein 1	126	13802	6.43	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	Neuromyotonia and axonal neuropathy, autosomal recessive	Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.	NA	Belongs to the HINT family.	NA	PE1	5
+NX_P49788	Retinoic acid receptor responder protein 1	294	33285	8.74	1	Membrane;Golgi apparatus;Endoplasmic reticulum	NA	Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.	Not glycosylated.	Belongs to the protease inhibitor I47 (latexin) family.	NA	PE1	3
+NX_P49789	Bis(5'-adenosyl)-triphosphatase	147	16858	6.54	0	Cytoplasm;Mitochondrion;Cell membrane;Nucleolus;Nucleus	NA	Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.	Phosphorylation at Tyr-114 by SRC is required for induction of apoptosis.	NA	Purine metabolism;Small cell lung cancer;Non-small cell lung cancer	PE1	3
+NX_P49790	Nuclear pore complex protein Nup153	1475	153938	8.97	0	Nucleus membrane;Nucleus;Nuclear pore complex	NA	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).	O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.;Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation.;Phosphorylated in interphase, hyperphosphorylated during mitosis. May play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).	Belongs to the NUP153 family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	6
+NX_P49792	E3 SUMO-protein ligase RanBP2	3224	358199	5.86	0	Nucleus membrane;Nucleus envelope;Nucleus;Nuclear pore complex	Encephalopathy, acute, infection-induced, 3	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830).	The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.;Polyubiquitinated by PRKN, which leads to proteasomal degradation.;RANBP2 is phosphorylated by MAPK3	Belongs to the RanBP2 E3 ligase family.	Protein modification; protein sumoylation.;RNA transport;Separation of Sister Chromatids;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	2
+NX_P49795	Regulator of G-protein signaling 19	217	24636	5.43	0	Membrane;Cell junction;Nucleolus	NA	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.	Fatty acylated. Heavily palmitoylated in the cysteine string motif.;Phosphorylated, mainly on serine residues.	NA	G alpha (i) signalling events;G alpha (q) signalling events;G alpha (z) signalling events	PE1	20
+NX_P49796	Regulator of G-protein signaling 3	1198	132336	5.9	0	Cytoplasm;Nucleus;Cell membrane	NA	Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.	Phosphorylated by cyclic GMP-dependent protein kinase.;ISGylated.	NA	Axon guidance;G alpha (i) signalling events;G alpha (q) signalling events	PE1	9
+NX_P49798	Regulator of G-protein signaling 4	205	23256	8.69	0	Cytoskeleton	Schizophrenia	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.	Palmitoylated on Cys-2 and/or Cys-12.;Phosphorylated by cyclic GMP-dependent protein kinase.	NA	G alpha (i) signalling events;G alpha (q) signalling events;G alpha (z) signalling events	PE1	1
+NX_P49802	Regulator of G-protein signaling 7	495	57668	8.33	0	Cytoplasm;Mitochondrion;Cell membrane;Membrane;Cytosol	NA	Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). May play a role in synaptic vesicle exocytosis (PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).	Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.;Palmitoylated.;Ubiquitinated, leading to rapid proteasomal degradation.	NA	G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	1
+NX_P49810	Presenilin-2	448	50140	4.51	8	Endoplasmic reticulum membrane;Golgi apparatus membrane	Cardiomyopathy, dilated 1V;Alzheimer disease 4	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369).	Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.;Phosphorylated on serine residues.	Belongs to the peptidase A22A family.	Notch signaling pathway;Neurotrophin signaling pathway;Alzheimer's disease;EPH-ephrin mediated repulsion of cells;Nuclear signaling by ERBB4;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Regulated proteolysis of p75NTR;NOTCH2 Activation and Transmission of Signal to the Nucleus;NRIF signals cell death from the nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3;NOTCH4 Activation and Transmission of Signal to the Nucleus	PE1	1
+NX_P49815	Tuberin	1807	200608	6.98	0	Membrane;Cytoplasm;Cytosol	Lymphangioleiomyomatosis;Focal cortical dysplasia 2;Tuberous sclerosis 2	In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).	Phosphorylation at Ser-1387, Ser-1418 or Ser-1420 does not affect interaction with TSC1. Phosphorylation at Ser-939 and Thr-1462 by PKB/AKT1 is induced by growth factor stimulation. Phosphorylation by AMPK activates it and leads to negatively regulates the mTORC1 complex. Phosphorylated at Ser-1798 by RPS6KA1; phosphorylation inhibits TSC2 ability to suppress mTORC1 signaling. Phosphorylated by DAPK1.;Ubiquitinated by the DCX(FBXW5) E3 ubiquitin-protein ligase complex, leading to its subsequent degradation. Ubiquitinated by MYCBP2 independently of its phosphorylation status leading to subsequent degradation; association with TSC1 protects from ubiquitination.;TSC2 is phosphorylated by DAPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);TSC2 is phosphorylated by PRKAA1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	p53 signaling pathway;mTOR signaling pathway;Insulin signaling pathway;Macroautophagy;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;Constitutive Signaling by AKT1 E17K in Cancer;AKT phosphorylates targets in the cytosol;Inhibition of TSC complex formation by PKB;TBC/RABGAPs	PE1	16
+NX_P49821	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	464	50817	8.51	0	Cytosol;Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 4	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).	NA	Belongs to the complex I 51 kDa subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	11
+NX_P49840	Glycogen synthase kinase-3 alpha	483	50981	8.95	0	Cytosol	NA	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899).	Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.	Chemokine signaling pathway;Dopaminergic synapse;XBP1(S) activates chaperone genes;Constitutive Signaling by AKT1 E17K in Cancer;AKT phosphorylates targets in the cytosol	PE1	19
+NX_P49841	Glycogen synthase kinase-3 beta	420	46744	8.98	0	Nucleoplasm;Cytoplasm;Nucleus;Cell membrane	NA	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and ARNTL/BMLA1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899).	Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity.;Phosphorylated by AKT1 and ILK1. Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-216 (PubMed:25169422). Inactivated by phosphorylation at Ser-9 (Probable). Phosphorylated in a circadian manner in the hippocampus (By similarity).	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.	ErbB signaling pathway;Chemokine signaling pathway;Cell cycle;Wnt signaling pathway;Hedgehog signaling pathway;Axon guidance;Focal adhesion;T cell receptor signaling pathway;B cell receptor signaling pathway;Neurotrophin signaling pathway;Dopaminergic synapse;Insulin signaling pathway;Melanogenesis;Alzheimer's disease;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Endometrial cancer;Prostate cancer;Basal cell carcinoma;Degradation of beta-catenin by the destruction complex;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Regulation of HSF1-mediated heat shock response;CRMPs in Sema3A signaling;Constitutive Signaling by AKT1 E17K in Cancer;Disassembly of the destruction complex and recruitment of AXIN to the membrane;AKT phosphorylates targets in the cytosol;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;B-WICH complex positively regulates rRNA expression;Regulation of RUNX2 expression and activity;Ubiquitin-dependent degradation of Cyclin D	PE1	3
+NX_P49842	Serine/threonine-protein kinase 19	368	40916	9.8	0	Nucleus speckle;Nucleus	NA	Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding to its downstream effectors.	NA	Belongs to the STK19 family.	NA	PE1	6
+NX_P49848	Transcription initiation factor TFIID subunit 6	677	72668	8.83	0	Nucleoplasm;Cytosol;Nucleus	Alazami-Yuan syndrome	TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.;Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700).	In cells undergoing apoptosis, cleaved in a caspase-dependent manner to produce a 40 kDa product.	Belongs to the TAF6 family.	Basal transcription factors;Herpes simplex infection;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA polymerase II transcribes snRNA genes;Regulation of TP53 Activity through Phosphorylation	PE1	7
+NX_P49862	Kallikrein-7	253	27525	8.82	0	Secreted;Nucleus membrane;Cell membrane	NA	May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.	NA	Belongs to the peptidase S1 family. Kallikrein subfamily.	Degradation of the extracellular matrix	PE1	19
+NX_P49863	Granzyme K	264	28882	9.48	0	Cytoplasmic granule;Secreted	NA	NA	NA	Belongs to the peptidase S1 family. Granzyme subfamily.	NA	PE1	5
+NX_P49888	Sulfotransferase 1E1	294	35126	6.18	0	Cytosol;Nucleus membrane	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110).	NA	Belongs to the sulfotransferase 1 family.	Steroid hormone biosynthesis;Sulfur metabolism;Cytosolic sulfonation of small molecules	PE1	4
+NX_P49895	Type I iodothyronine deiodinase	249	28924	8.9	1	Endoplasmic reticulum membrane	NA	Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.	NA	Belongs to the iodothyronine deiodinase family.	Regulation of thyroid hormone activity	PE1	1
+NX_P49901	Sperm mitochondrial-associated cysteine-rich protein	116	12767	8.49	0	Mitochondrion membrane;Cytoplasm	NA	Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).	NA	NA	NA	PE1	1
+NX_P49902	Cytosolic purine 5'-nucleotidase	561	64970	5.75	0	Cytoplasm	Spastic paraplegia 45, autosomal recessive	May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.	NA	Belongs to the 5'(3')-deoxyribonucleotidase family.	Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Purine catabolism;Abacavir metabolism	PE1	10
+NX_P49903	Selenide, water dikinase 1	392	42911	5.65	0	Cytoplasm;Nucleoplasm;Nucleus membrane;Cell membrane	NA	Synthesizes selenophosphate from selenide and ATP.	NA	Belongs to the selenophosphate synthase 1 family. Class II subfamily.	Selenocompound metabolism;Metabolic pathways	PE1	10
+NX_P49908	Selenoprotein P	381	43174	8.08	0	Golgi apparatus;Nucleoplasm;Secreted	NA	Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.	Phosphorylation sites are present in the extracellular medium.	Belongs to the selenoprotein P family.	Platelet degranulation	PE1	5
+NX_P49910	Zinc finger protein 165	485	55771	6.74	0	Nucleus speckle;Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_P49913	Cathelicidin antimicrobial peptide	170	19301	9.48	0	Secreted	NA	Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.	The N-terminus is blocked.	Belongs to the cathelicidin family.	Salivary secretion;Tuberculosis;Neutrophil degranulation;Antimicrobial peptides	PE1	3
+NX_P49914	5-formyltetrahydrofolate cyclo-ligase	203	23256	7.71	0	Cytoplasm;Cytosol	Neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination	Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.	NA	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.	One carbon pool by folate;Metabolic pathways;Metabolism of folate and pterines	PE1	15
+NX_P49915	GMP synthase [glutamine-hydrolyzing]	693	76715	6.42	0	Cytoplasm;Cytosol	NA	Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.	NA	NA	Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.;Purine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Purine ribonucleoside monophosphate biosynthesis	PE1	3
+NX_P49916	DNA ligase 3	1009	112907	9.17	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).;Functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.	NA	Belongs to the ATP-dependent DNA ligase family.	Base excision repair;Resolution of AP sites via the single-nucleotide replacement pathway;APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through MMEJ (alt-NHEJ);Gap-filling DNA repair synthesis and ligation in GG-NER	PE1	17
+NX_P49917	DNA ligase 4	911	103971	8.17	0	Nucleoplasm;Cytosol;Nucleus	LIG4 syndrome;Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-positive with sensitivity to ionizing radiation	Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.	NA	Belongs to the ATP-dependent DNA ligase family.	Non-homologous end-joining;2-LTR circle formation;Nonhomologous End-Joining (NHEJ)	PE1	13
+NX_P49918	Cyclin-dependent kinase inhibitor 1C	316	32177	5.39	0	Nucleoplasm;Cytosol;Nucleus	Beckwith-Wiedemann syndrome;Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.	NA	Belongs to the CDI family.	Cell cycle;Cyclin D associated events in G1	PE1	11
+NX_P49959	Double-strand break repair protein MRE11	708	80593	5.61	0	Nucleoplasm;Telomere;Nucleus;Chromosome	Ataxia-telangiectasia-like disorder 1	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289, PubMed:30612738). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).	Ubiquitinated following DNA damage. Ubiquitination triggers interaction with UBQLN4, leading to MRE11 removal from chromatin and degradation by the proteasome.	Belongs to the MRE11/RAD32 family.	Homologous recombination;Non-homologous end-joining;Cytosolic sensors of pathogen-associated DNA;DNA Damage/Telomere Stress Induced Senescence;Meiotic recombination;G2/M DNA damage checkpoint;IRF3-mediated induction of type I IFN;Sensing of DNA Double Strand Breaks;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Single Strand Annealing (SSA);HDR through MMEJ (alt-NHEJ);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Nonhomologous End-Joining (NHEJ);Regulation of TP53 Activity through Phosphorylation	PE1	11
+NX_P49961	Ectonucleoside triphosphate diphosphohydrolase 1	510	57965	5.93	2	Membrane;Cytoskeleton	Spastic paraplegia 64, autosomal recessive	In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.	The N-terminus is blocked.;Palmitoylated in the N-terminal part.	Belongs to the GDA1/CD39 NTPase family.	Purine metabolism;Pyrimidine metabolism;Phosphate bond hydrolysis by NTPDase proteins	PE1	10
+NX_P50052	Type-2 angiotensin II receptor	363	41184	9.31	7	Cell membrane	NA	Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Renin-angiotensin system;G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	X
+NX_P50053	Ketohexokinase	298	32523	5.91	0	Cytosol	Fructosuria	Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.	NA	Belongs to the carbohydrate kinase PfkB family.	Carbohydrate metabolism; fructose metabolism.;Fructose and mannose metabolism;Metabolic pathways;Fructose catabolism;Essential fructosuria	PE1	2
+NX_P50120	Retinol-binding protein 2	134	15707	5.27	0	Golgi apparatus;Cytoplasm	NA	Intracellular transport of retinol.	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Vitamin digestion and absorption;Retinoid metabolism and transport	PE1	3
+NX_P50135	Histamine N-methyltransferase	292	33295	5.18	0	Nucleoplasm;Cytosol;Cytoplasm;Centrosome	Mental retardation, autosomal recessive 51	Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.	Histidine metabolism;Histidine catabolism;Metabolism of ingested SeMet, Sec, MeSec into H2Se	PE1	2
+NX_P50148	Guanine nucleotide-binding protein G(q) subunit alpha	359	42142	5.48	0	Nucleus speckle;Cell membrane;Nucleus membrane;Membrane;Cytosol;Nucleus	Sturge-Weber syndrome;Capillary malformations, congenital	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity).	(Microbial infection) Deamidated at Gln-209 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.	Belongs to the G-alpha family. G(q) subfamily.	Calcium signaling pathway;Vascular smooth muscle contraction;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;Dopaminergic synapse;Long-term depression;GnRH signaling pathway;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Alzheimer's disease;Huntington's disease;Chagas disease (American trypanosomiasis);African trypanosomiasis;Amoebiasis;G alpha (q) signalling events;ADP signalling through P2Y purinoceptor 1;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion;Acetylcholine regulates insulin secretion	PE1	9
+NX_P50150	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	75	8389	6.55	0	Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the G protein gamma family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	1
+NX_P50151	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	68	7205	7.71	0	Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.	NA	Belongs to the G protein gamma family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	9
+NX_P50213	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	366	39592	6.46	0	Mitochondrion	NA	Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.	NA	Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Citrate cycle (TCA cycle);Metabolic pathways;Citric acid cycle (TCA cycle)	PE1	15
+NX_P50219	Motor neuron and pancreas homeobox protein 1	401	40569	7.27	0	Nucleoplasm;Nucleolus;Nucleus;Cytosol	Currarino syndrome	Putative transcription factor involved in pancreas development and function.	NA	NA	Maturity onset diabetes of the young	PE1	7
+NX_P50221	Homeobox protein MOX-1	254	27997	7.79	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Klippel-Feil syndrome 2, autosomal recessive	Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.	NA	NA	NA	PE1	17
+NX_P50222	Homeobox protein MOX-2	304	33594	7.87	0	Nucleus speckle;Nucleus	NA	Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.	NA	NA	NA	PE1	7
+NX_P50225	Sulfotransferase 1A1	295	34165	6.16	0	Cytoplasm	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. Responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.	NA	Belongs to the sulfotransferase 1 family.	Sulfur metabolism;Cytosolic sulfonation of small molecules	PE1	16
+NX_P50226	Sulfotransferase 1A2	295	34310	7.75	0	Cytoplasm	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.	NA	Belongs to the sulfotransferase 1 family.	Sulfur metabolism;Cytosolic sulfonation of small molecules	PE1	16
+NX_P50238	Cysteine-rich protein 1	77	8533	9.05	0	Cytosol;Nucleus speckle;Centrosome;Cell membrane	NA	Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.	NA	NA	NA	PE1	14
+NX_P50281	Matrix metalloproteinase-14	582	65894	7.63	1	Cytoplasm;Membrane;Melanosome;Cytosol;Cytoskeleton	Winchester syndrome	Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140).	Tyrosine phosphorylated by PKDCC/VLK.;The precursor is cleaved by a furin endopeptidase.;MMP14 is phosphorylated by FGFR4	Belongs to the peptidase M10A family.	GnRH signaling pathway;Degradation of the extracellular matrix;Collagen degradation;Activation of Matrix Metalloproteinases	PE1	14
+NX_P50336	Protoporphyrinogen oxidase	477	50765	8.43	0	Golgi apparatus;Mitochondrion inner membrane;Cytoplasmic vesicle	Variegate porphyria	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.	NA	Belongs to the protoporphyrinogen oxidase family.	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.;Porphyrin and chlorophyll metabolism;Metabolic pathways;Heme biosynthesis	PE1	1
+NX_P50391	Neuropeptide Y receptor type 4	375	42195	8.46	7	Cell membrane	NA	Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE2	10
+NX_P50395	Rab GDP dissociation inhibitor beta	445	50663	6.11	0	Membrane;Cytoplasm	NA	Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.	NA	Belongs to the Rab GDI family.	Rho GTPase cycle;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs	PE1	10
+NX_P50402	Emerin	254	28994	5.29	1	Nucleus outer membrane;Nucleus membrane;Endoplasmic reticulum;Nucleus inner membrane;Nucleus envelope	Emery-Dreifuss muscular dystrophy 1, X-linked	Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.	Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.	NA	Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina;Nuclear Envelope Breakdown;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	X
+NX_P50406	5-hydroxytryptamine receptor 6	440	46954	9.27	7	Cell membrane	NA	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Serotonin receptors	PE1	1
+NX_P50416	Carnitine O-palmitoyltransferase 1, liver isoform	773	88368	8.85	2	Mitochondrion outer membrane;Mitochondrion	Carnitine palmitoyltransferase 1A deficiency	Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.	NA	Belongs to the carnitine/choline acetyltransferase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid metabolism;PPAR signaling pathway;Adipocytokine signaling pathway;PPARA activates gene expression;RORA activates gene expression;Signaling by Retinoic Acid;Import of palmitoyl-CoA into the mitochondrial matrix	PE1	11
+NX_P50440	Glycine amidinotransferase, mitochondrial	423	48455	8.26	0	Cytoplasm;Mitochondrion inner membrane;Mitochondrion	Cerebral creatine deficiency syndrome 3	Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.	NA	Belongs to the amidinotransferase family.	Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2.;Glycine, serine and threonine metabolism;Arginine and proline metabolism;Metabolic pathways;Creatine metabolism	PE1	15
+NX_P50443	Sulfate transporter	739	81662	8.67	8	Cytoplasmic vesicle;Cell membrane	Atelosteogenesis 2;Multiple epiphyseal dysplasia 4;Achondrogenesis 1B;Diastrophic dysplasia	Sulfate transporter. May play a role in endochondral bone formation.	NA	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Transport and synthesis of PAPS;Multifunctional anion exchangers;Defective SLC26A2 causes chondrodysplasias	PE1	5
+NX_P50452	Serpin B8	374	42767	5.41	0	Nucleoplasm;Cytosol;Cytoplasm	Peeling skin syndrome 5	Has an important role in epithelial desmosome-mediated cell-cell adhesion.	NA	Belongs to the serpin family. Ov-serpin subfamily.	Dissolution of Fibrin Clot	PE1	18
+NX_P50453	Serpin B9	376	42404	5.61	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Granzyme B inhibitor.	NA	Belongs to the serpin family. Ov-serpin subfamily.	Amoebiasis	PE1	6
+NX_P50454	Serpin H1	418	46441	8.75	0	Endoplasmic reticulum;Endoplasmic reticulum lumen	Osteogenesis imperfecta 10	Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.	NA	Belongs to the serpin family.	Collagen biosynthesis and modifying enzymes	PE1	11
+NX_P50458	LIM/homeobox protein Lhx2	406	44373	8.81	0	Nucleoplasm;Nucleus	NA	Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity).	NA	NA	Regulation of expression of SLITs and ROBOs	PE1	9
+NX_P50461	Cysteine and glycine-rich protein 3	194	20969	8.89	0	Cytoplasm;Sarcomere;Z line;Nucleus;Cytoskeleton	Cardiomyopathy, familial hypertrophic 12;Cardiomyopathy, dilated 1M	May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization.;Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity).	Phosphorylated by PKC/PRKCA.	NA	NA	PE1	11
+NX_P50479	PDZ and LIM domain protein 4	330	35398	8.07	0	Cytoplasm;Dendritic spine;Synaptosome;Lamellipodium;Recycling endosome membrane;Early endosome membrane;Cytosol;Perinuclear region;Nucleus;Cytoskeleton	NA	Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity).;Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration.	Phosphorylated on tyrosine residue(s). Can be dephosphorylated by PTPN13.	NA	NA	PE1	5
+NX_P50502	Hsc70-interacting protein	369	41332	5.18	0	Cytoplasm	NA	One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).	NA	Belongs to the FAM10 family.	Regulation of HSF1-mediated heat shock response	PE1	22
+NX_P50539	Max-interacting protein 1	228	26062	6.57	0	Nucleus;Nucleoplasm;Cytosol;Nucleolus	Prostate cancer	Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.	NA	NA	NA	PE1	10
+NX_P50542	Peroxisomal targeting signal 1 receptor	639	70865	4.43	0	Golgi apparatus;Cytoplasm;Cytosol;Peroxisome membrane	Peroxisome biogenesis disorder 2A;Peroxisome biogenesis disorder 2B;Rhizomelic chondrodysplasia punctata 5	Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.	Monoubiquitination at Cys-11 is required for proper export from peroxisomes and recycling.	Belongs to the peroxisomal targeting signal receptor family.	Peroxisome;E3 ubiquitin ligases ubiquitinate target proteins;Peroxisomal protein import	PE1	12
+NX_P50548	ETS domain-containing transcription factor ERF	548	58703	6.85	0	Nucleoplasm;Nucleus	Chitayat syndrome;Craniosynostosis 4	Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity).	Phosphorylated by multiple kinases including MAPK1/ERK2 at THR-526. Phosphorylation regulates the activity of ERF.	Belongs to the ETS family.	Oncogene Induced Senescence	PE1	19
+NX_P50549	ETS translocation variant 1	477	55131	5.7	0	Nucleoplasm;Nucleus	Ewing sarcoma	Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.	Sumoylated.;Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity.	Belongs to the ETS family.	NA	PE1	7
+NX_P50552	Vasodilator-stimulated phosphoprotein	380	39830	9.05	0	Cytoplasm;Filopodium membrane;Cell membrane;Cell junction;Focal adhesion;Lamellipodium membrane;Tight junction;Cytoskeleton	NA	Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.	Major substrate for cAMP-dependent (PKA) and cGMP-dependent protein kinase (PKG) in platelets. The preferred site for PKA is Ser-157, the preferred site for PKG/PRKG1, Ser-239. In ADP-activated platelets, phosphorylation by PKA or PKG on Ser-157 leads to fibrinogen receptor inhibition. Phosphorylation on Thr-278 requires prior phosphorylation on Ser-157 and Ser-239. In response to phorbol ester (PMA) stimulation, phosphorylated by PKC/PRKCA. In response to thrombin, phosphorylated by both PKC and ROCK1. Phosphorylation at Thr-278 by AMPK does not require prior phosphorylation at Ser-157 or Ser-239. Phosphorylation at Ser-157 by PKA is required for localization to the tight junctions in epithelial cells. Phosphorylation modulates F-actin binding, actin filament elongation and platelet activation. Phosphorylation at Ser-322 by AMPK also alters actin filament binding. Carbon monoxide (CO) promotes phosphorylation at Ser-157, while nitric oxide (NO) promotes phosphorylation at Ser-157, but also at Ser-239. Response to NO and CO is blunted in platelets from diabetic patients, and VASP is not phosphorylated efficiently at Ser-157 and Ser-239.	Belongs to the Ena/VASP family.	Focal adhesion;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Generation of second messenger molecules;Signaling by ROBO receptors;Cell-extracellular matrix interactions	PE1	19
+NX_P50553	Achaete-scute homolog 1	236	25454	8.93	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation.	NA	NA	NA	PE1	12
+NX_P50570	Dynamin-2	870	98064	7.04	0	Cytoplasm;Golgi apparatus;Phagosome membrane;Cell junction;Clathrin-coated pit;Phagocytic cup;Postsynaptic density;Synapse;Cytosol;Midbody;Cytoskeleton	Charcot-Marie-Tooth disease 2M;Myopathy, centronuclear, 1;Lethal congenital contracture syndrome 5;Charcot-Marie-Tooth disease, dominant, intermediate type, B	Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity).	Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2 (By similarity). Phosphorylated on tyrosine residues after activation of SRC (By similarity).;DNM2 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Endocytosis;Fc gamma R-mediated phagocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Bacterial invasion of epithelial cells;MHC class II antigen presentation;Toll Like Receptor 4 (TLR4) Cascade;Golgi Associated Vesicle Biogenesis;Retrograde neurotrophin signalling;Lysosome Vesicle Biogenesis;Recycling pathway of L1;Gap junction degradation;NOSTRIN mediated eNOS trafficking;Formation of annular gap junctions;Clathrin-mediated endocytosis	PE1	19
+NX_P50579	Methionine aminopeptidase 2	478	52892	5.57	0	Cytoplasm;Cytosol;Cell membrane	NA	Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.;Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.	Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.	Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.	Inactivation, recovery and regulation of the phototransduction cascade	PE1	12
+NX_P50583	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]	147	16829	5.23	0	Nucleoplasm	NA	Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.	NA	Belongs to the Nudix hydrolase family.	Purine metabolism;Pyrimidine metabolism;Detoxification of Reactive Oxygen Species	PE1	9
+NX_P50591	Tumor necrosis factor ligand superfamily member 10	281	32509	7.01	1	Secreted;Cell membrane;Cytoskeleton	NA	Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.	Tyrosine phosphorylated by PKDCC/VLK.	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;Apoptosis;Natural killer cell mediated cytotoxicity;Measles;Influenza A;Caspase activation via Death Receptors in the presence of ligand;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TRAIL signaling	PE1	3
+NX_P50607	Tubby protein homolog	506	55651	8.88	0	Cytoplasm;Cell membrane;Centriolar satellite;Secreted;Nucleolus;Nucleus	Retinal dystrophy and obesity	Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.	TUB is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	Belongs to the TUB family.	NA	PE1	11
+NX_P50613	Cyclin-dependent kinase 7	346	39038	8.66	0	Cytoplasm;Perinuclear region;Nucleus	NA	Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.	Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for activity. Phosphorylated at Ser-164 and Thr-170 by CDK2.;CDK7 is phosphorylated by PRKCB	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Basal transcription factors;Nucleotide excision repair;Cell cycle;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Tat-mediated elongation of the HIV-1 transcript;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Cyclin E associated events during G1/S transition;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A:Cdk2-associated events at S phase entry;Cyclin D associated events in G1;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Formation of Incision Complex in GG-NER;RNA polymerase II transcribes snRNA genes;TP53 Regulates Transcription of DNA Repair Genes;RUNX1 regulates transcription of genes involved in differentiation of HSCs	PE1	5
+NX_P50616	Protein Tob1	345	38155	6.45	0	Nucleoplasm;Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).	Phosphorylated on Ser and Thr residues.	Belongs to the BTG family.	RNA degradation	PE1	17
+NX_P50747	Biotin--protein ligase	726	80760	5.4	0	Cytoplasm;Cytosol;Mitochondrion	Holocarboxylase synthetase deficiency	Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.	NA	Belongs to the biotin--protein ligase family.	Biotin metabolism;Metabolic pathways;Biotin transport and metabolism;Defective HLCS causes multiple carboxylase deficiency	PE1	21
+NX_P50748	Kinetochore-associated protein 1	2209	250749	5.67	0	Kinetochore;Cytoplasm;Cell membrane;Cytosol;Spindle;Nucleus	NA	Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.	NA	NA	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	12
+NX_P50749	Ras association domain-containing protein 2	326	37790	8.93	0	Kinetochore;Golgi apparatus;Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.	Phosphorylated by STK3/MST2 and STK4/MST1.	NA	NA	PE1	20
+NX_P50750	Cyclin-dependent kinase 9	372	42778	8.97	0	Cytoplasm;Nucleoplasm;PML body;Cytosol;Nucleus	NA	Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.	N6-acetylation of Lys-44 by CBP/p300 promotes kinase activity, whereas acetylation of both Lys-44 and Lys-48 mediated by PCAF/KAT2B and GCN5/KAT2A reduces kinase activity. The acetylated form associates with PML bodies in the nuclear matrix and with the transcriptionally silent HIV-1 genome; deacetylated upon transcription stimulation.;Polyubiquitinated and thus activated by UBR5. This ubiquitination is promoted by TFIIS/TCEA1 and favors 'Ser-2' phosphorylation of RPB1/POLR2A CTD.;Dephosphorylation of Thr-186 by PPM1A and PPM1B blocks CDK9 activity and may lead to CDK9 proteasomal degradation. However, PPP1CA-mediated Thr-186 dephosphorylation is required to release P-TEFb from its inactive P-TEFb/7SK snRNP complex. Dephosphorylation of C-terminus Thr and Ser residues by protein phosphatase-1 (PP1) triggers CDK9 activity, contributing to the activation of HIV-1 transcription.;Autophosphorylation at Thr-186, Ser-347, Thr-350, Ser-353, Thr-354 and Ser-357 triggers kinase activity by promoting cyclin and substrate binding (e.g. HIV TAT) upon conformational changes. Thr-186 phosphorylation requires the calcium Ca(2+) signaling pathway, including CaMK1D and calmodulin. This inhibition is relieved by Thr-29 dephosphorylation. However, phosphorylation at Thr-29 is inhibitory within the HIV transcription initiation complex. Phosphorylation at Ser-175 inhibits kinase activity. Can be phosphorylated on either Thr-362 or Thr-363 but not on both simultaneously (PubMed:18566585).	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;Interactions of Tat with host cellular proteins;RNA polymerase II transcribes snRNA genes;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	9
+NX_P50851	Lipopolysaccharide-responsive and beige-like anchor protein	2863	319108	5.39	1	trans-Golgi network;Golgi apparatus;Cell membrane;Endoplasmic reticulum;Lysosome;Cytosol	Immunodeficiency, common variable, 8, with autoimmunity	May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules.	NA	NA	NA	PE1	4
+NX_P50876	E3 ubiquitin-protein ligase RNF144A	292	32890	5.91	1	Cytoplasmic vesicle;Cytoplasmic vesicle membrane;Cell membrane	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.	Autoubiquitinated.	Belongs to the RBR family. RNF144 subfamily.	Protein modification; protein ubiquitination.;E3 ubiquitin ligases ubiquitinate target proteins	PE1	2
+NX_P50895	Basal cell adhesion molecule	628	67405	5.53	1	Membrane;Nucleolus	NA	Laminin alpha-5 receptor. May mediate intracellular signaling.	Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.	NA	NA	PE1	19
+NX_P50897	Palmitoyl-protein thioesterase 1	306	34193	6.07	0	Golgi apparatus;Lysosome;Secreted;Cytoplasmic vesicle	Ceroid lipofuscinosis, neuronal, 1	Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748).	Glycosylated.	Belongs to the palmitoyl-protein thioesterase family.	Fatty acid elongation;Metabolic pathways;Lysosome;Fatty acyl-CoA biosynthesis	PE1	1
+NX_P50914	60S ribosomal protein L14	215	23432	10.94	0	Cytoplasm	NA	Component of the large ribosomal subunit.	NA	Belongs to the eukaryotic ribosomal protein eL14 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	3
+NX_P50990	T-complex protein 1 subunit theta	548	59621	5.42	0	Cytoplasm;Cilium basal body;Nucleoplasm;Centrosome;Cytosol;Cytoskeleton	NA	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).	NA	Belongs to the TCP-1 chaperonin family.	BBSome-mediated cargo-targeting to cilium;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Neutrophil degranulation	PE1	21
+NX_P50991	T-complex protein 1 subunit delta	539	57924	7.96	0	Cytoplasm;Cilium basal body;Nucleoplasm;Melanosome;Centrosome;Cytosol	NA	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).	NA	Belongs to the TCP-1 chaperonin family.	BBSome-mediated cargo-targeting to cilium;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	2
+NX_P50993	Sodium/potassium-transporting ATPase subunit alpha-2	1020	112265	5.47	10	Membrane;Cell membrane	Alternating hemiplegia of childhood 1;Migraine, familial hemiplegic, 2	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.	Cardiac muscle contraction;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Protein digestion and absorption;Bile secretion;Mineral absorption;Ion transport by P-type ATPases;Ion homeostasis	PE1	1
+NX_P50995	Annexin A11	505	54390	7.53	0	Cytoplasm;Nucleoplasm;Nucleus envelope;Melanosome;Cytosol;Spindle	Amyotrophic lateral sclerosis 23	Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.	NA	Belongs to the annexin family.	NA	PE1	10
+NX_P51003	Poly(A) polymerase alpha	745	82843	6.96	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.	Hyperphosphorylation on multiple CDK2 consensus and non-consensus sites in the C-terminal Ser/Thr-rich region represses PAP activity in late M-phase. Phosphorylation/dephosphorylation may regulate the interaction between PAP and CPSF (By similarity).;Polysumoylated. Varying sumolyation depending on tissue- and cell-type. Highly sumoylated in bladder and NIH 3T3 cells. Sumoylation is required for nuclear localization and enhances PAP stability. Desumoylated by SENP1. Inhibits polymerase activity (By similarity).;Acetylated in the C-terminus. Acetylation decreases interaction with NUDT21 and KPNB1, and inhibits nuclear localization through inhibiting binding to the importin alpha/beta complex (By similarity).	Belongs to the poly(A) polymerase family.	mRNA surveillance pathway;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	14
+NX_P51114	Fragile X mental retardation syndrome-related protein 1	621	69721	5.84	0	Cytoplasm;Cytosol	NA	RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity).	Arg-445 is dimethylated, probably to asymmetric dimethylarginine.	Belongs to the FMR1 family.	Signaling by BRAF and RAF fusions	PE1	3
+NX_P51116	Fragile X mental retardation syndrome-related protein 2	673	74223	5.95	0	Cytoplasm;Cytosol	NA	RNA-binding protein.	NA	Belongs to the FMR1 family.	NA	PE1	17
+NX_P51124	Granzyme M	257	27545	10.16	0	Cytoplasmic granule;Secreted	NA	Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.	NA	Belongs to the peptidase S1 family. Granzyme subfamily.	Alternative complement activation	PE1	19
+NX_P51148	Ras-related protein Rab-5C	216	23483	8.64	0	Early endosome membrane;Endosome;Melanosome;Cell membrane	NA	Protein transport. Probably involved in vesicular traffic (By similarity).	Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.	Belongs to the small GTPase superfamily. Rab family.	Endocytosis;Phagosome;Vasopressin-regulated water reabsorption;Amoebiasis;Tuberculosis;Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs;RAB geranylgeranylation	PE1	17
+NX_P51149	Ras-related protein Rab-7a	207	23490	6.39	0	Autophagosome membrane;Endosome membrane;Lipid droplet;Phagosome membrane;Lysosome membrane;Lysosome;Melanosome membrane;Late endosome membrane	Charcot-Marie-Tooth disease 2B	Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).	NA	Belongs to the small GTPase superfamily. Rab family.	Endocytosis;Phagosome;Salmonella infection;Amoebiasis;Tuberculosis;MHC class II antigen presentation;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs;RAB geranylgeranylation	PE1	3
+NX_P51151	Ras-related protein Rab-9A	201	22838	5.26	0	Endoplasmic reticulum membrane;Cell membrane;Phagosome membrane;Cytoplasmic vesicle membrane;Nucleoplasm;Melanosome;Phagosome;Late endosome;Golgi apparatus membrane;Cytosol	NA	Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.	NA	Belongs to the small GTPase superfamily. Rab family.	Measles;Retrograde transport at the Trans-Golgi-Network;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	X
+NX_P51153	Ras-related protein Rab-13	203	22774	9.27	0	Cell membrane;trans-Golgi network membrane;Cytoplasmic vesicle membrane;Tight junction;Lamellipodium;Recycling endosome membrane;Cytosol	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.	NA	Belongs to the small GTPase superfamily. Rab family.	Tight junction;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	1
+NX_P51157	Ras-related protein Rab-28	221	24841	5.7	0	Cilium basal body;Cell membrane	Cone-rod dystrophy 18	NA	NA	Belongs to the small GTPase superfamily. Rab family.	NA	PE1	4
+NX_P51159	Ras-related protein Rab-27A	221	24868	5.09	0	Membrane;Melanosome;Late endosome;Lysosome	Griscelli syndrome 2	Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	NA	Belongs to the small GTPase superfamily. Rab family.	Insulin processing;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	15
+NX_P51160	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	858	99147	5.5	0	Cell membrane	Cone dystrophy 4;Achromatopsia 5	As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.	NA	Belongs to the cyclic nucleotide phosphodiesterase family.	Purine metabolism	PE1	10
+NX_P51161	Gastrotropin	128	14371	6.29	0	Membrane;Cytoplasm	NA	Essential for the survival of colon cancer cells to bile acid-induced apoptosis.;Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	PPAR signaling pathway;Triglyceride catabolism;Recycling of bile acids and salts	PE1	5
+NX_P51164	Potassium-transporting ATPase subunit beta	291	33367	6.98	1	Cell membrane	NA	Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.	NA	Belongs to the X(+)/potassium ATPases subunit beta family.	Oxidative phosphorylation;Collecting duct acid secretion;Gastric acid secretion;Ion transport by P-type ATPases	PE1	13
+NX_P51168	Amiloride-sensitive sodium channel subunit beta	640	72659	5.89	2	Cytoplasmic vesicle membrane;Apical cell membrane	Liddle syndrome 1;Bronchiectasis with or without elevated sweat chloride 1;Pseudohypoaldosteronism 1, autosomal recessive	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.	Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.;N-glycosylated. N-glycosylation is required for interaction with BPIFA1.	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.	Taste transduction;Aldosterone-regulated sodium reabsorption;Stimuli-sensing channels	PE1	16
+NX_P51170	Amiloride-sensitive sodium channel subunit gamma	649	74270	7.47	2	Nucleoplasm;Apical cell membrane;Cell membrane	Bronchiectasis with or without elevated sweat chloride 3;Liddle syndrome 2	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.	Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.;ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.;Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.	Taste transduction;Aldosterone-regulated sodium reabsorption;Stimuli-sensing channels	PE1	16
+NX_P51172	Amiloride-sensitive sodium channel subunit delta	802	87850	8.87	2	Cytoskeleton;Cell membrane	NA	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.	NA	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1D subfamily.	Stimuli-sensing channels	PE1	1
+NX_P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	756	85665	6.23	0	Cytoskeleton	Nail disorder, non-syndromic congenital, 3	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Phosphatidylinositol signaling system;Synthesis of IP3 and IP4 in the cytosol	PE1	3
+NX_P51397	Death-associated protein 1	102	11165	9.3	0	Cytoplasm	NA	Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.	Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.	NA	NA	PE1	5
+NX_P51398	28S ribosomal protein S29, mitochondrial	398	45566	9.02	0	Nucleoplasm;Mitochondrion	NA	Involved in mediating interferon-gamma-induced cell death.	NA	Belongs to the mitochondrion-specific ribosomal protein mS29 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	1
+NX_P51449	Nuclear receptor ROR-gamma	518	58195	8.88	0	Nucleus	Immunodeficiency 42	Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches. Required for the generation of LTi (lymphoid tissue inducer) cells. Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus.;Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376).	NA	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Circadian rhythm - mammal;Nuclear Receptor transcription pathway;Interleukin-4 and Interleukin-13 signaling;RUNX3 Regulates Immune Response and Cell Migration	PE1	1
+NX_P51451	Tyrosine-protein kinase Blk	505	57706	7.98	0	Nucleoplasm;Cell membrane	Maturity-onset diabetes of the young 11	Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214).	Ubiquitination of activated BLK by the UBE3A ubiquitin protein ligase leads to its degradation by the ubiquitin-proteasome pathway.;Phosphorylated on tyrosine residues after antibody-mediated surface engagement of the B-cell antigen receptor (BCR).;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;RUNX1 regulates transcription of genes involved in BCR signaling	PE1	8
+NX_P51452	Dual specificity protein phosphatase 3	185	20478	7.66	0	Nucleoplasm;Cytosol;Nucleus	NA	Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.	DUSP3 is phosphorylated by SYK	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway;ERKs are inactivated	PE1	17
+NX_P51460	Insulin-like 3	131	14502	9.18	0	Secreted	Cryptorchidism	Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.	NA	Belongs to the insulin family.	Relaxin receptors;G alpha (s) signalling events	PE1	19
+NX_P51504	Zinc finger protein 80	273	31224	9.04	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE2	3
+NX_P51508	Zinc finger protein 81	661	75960	8.96	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	X
+NX_P51511	Matrix metalloproteinase-15	669	75807	7.03	1	Membrane;Nucleoplasm;Cytosol;Cell membrane	NA	Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.	The precursor is cleaved by a furin endopeptidase.	Belongs to the peptidase M10A family.	Degradation of the extracellular matrix;Collagen degradation;Activation of Matrix Metalloproteinases	PE1	16
+NX_P51512	Matrix metalloproteinase-16	607	69521	8.72	1	Extracellular matrix;Cell membrane;Cell surface;Cytoplasmic vesicle;Cytosol	NA	Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels.;Cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.	The precursor is cleaved by a furin endopeptidase.	Belongs to the peptidase M10A family.	Activation of Matrix Metalloproteinases	PE1	8
+NX_P51513	RNA-binding protein Nova-1	507	51727	8.8	0	Nucleoplasm;Nucleolus;Nucleus	NA	May regulate RNA splicing or metabolism in a specific subset of developing neurons.	NA	NA	NA	PE1	14
+NX_P51522	Zinc finger protein 83	516	59710	9.38	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P51523	Zinc finger protein 84	738	85457	9.05	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	12
+NX_P51530	DNA replication ATP-dependent helicase/nuclease DNA2	1060	120415	7.95	0	Mitochondrion;Nucleus	Seckel syndrome 8;Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 6	Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.	Acetylated by EP300, leading to stimulate the 5'-3' endonuclease, the 5'-3' helicase and DNA-dependent ATPase activities, possibly by increasing DNA substrate affinity.	Belongs to the DNA2/NAM7 helicase family.	DNA replication;G2/M DNA damage checkpoint;Removal of the Flap Intermediate from the C-strand;Removal of the Flap Intermediate;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	10
+NX_P51531	Probable global transcription activator SNF2L2	1590	181279	6.76	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus;Cytoskeleton	Nicolaides-Baraitser syndrome;Schizophrenia	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).	NA	Belongs to the SNF2/RAD54 helicase family.	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	9
+NX_P51532	Transcription activator BRG1	1647	184646	7.83	0	Nucleoplasm;Nucleus	Rhabdoid tumor predisposition syndrome 2;Coffin-Siris syndrome 4	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity).	NA	Belongs to the SNF2/RAD54 helicase family.	RMTs methylate histone arginines;Interleukin-7 signaling;Formation of the beta-catenin:TCF transactivating complex;Chromatin modifying enzymes;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	19
+NX_P51553	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	393	42794	8.75	0	Mitochondrion;Nucleolus	NA	Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.	NA	Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Citrate cycle (TCA cycle);Metabolic pathways;Mitochondrial protein import;Citric acid cycle (TCA cycle)	PE1	X
+NX_P51570	Galactokinase	392	42272	6.04	0	Golgi apparatus;Cytosol	Galactosemia II	Major enzyme for galactose metabolism.	NA	Belongs to the GHMP kinase family. GalK subfamily.	Carbohydrate metabolism; galactose metabolism.;Galactose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Galactose catabolism;Defective GALK1 can cause Galactosemia II (GALCT2)	PE1	17
+NX_P51571	Translocon-associated protein subunit delta	173	18999	5.76	1	Endoplasmic reticulum membrane	Congenital disorder of glycosylation 1Y	TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.	NA	Belongs to the TRAP-delta family.	Protein processing in endoplasmic reticulum;SRP-dependent cotranslational protein targeting to membrane	PE1	X
+NX_P51572	B-cell receptor-associated protein 31	246	27992	8.44	3	Endoplasmic reticulum;Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane	Deafness, dystonia, and cerebral hypomyelination	Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis.	Cleaved by CASP8 and other caspases.	Belongs to the BCAP29/BCAP31 family.	Protein processing in endoplasmic reticulum;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Apoptotic cleavage of cellular proteins;Apoptotic execution phase	PE1	X
+NX_P51575	P2X purinoceptor 1	399	44980	8.75	2	Membrane	NA	Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity).	NA	Belongs to the P2X receptor family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Elevation of cytosolic Ca2+ levels;Platelet homeostasis;Neutrophil degranulation	PE1	17
+NX_P51580	Thiopurine S-methyltransferase	245	28180	5.85	0	Cytoplasm	NA	Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.	Drug metabolism - other enzymes;Methylation;Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)	PE1	6
+NX_P51582	P2Y purinoceptor 4	365	40963	8.92	7	Cell membrane	NA	Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.	Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;P2Y receptors	PE1	X
+NX_P51587	Breast cancer type 2 susceptibility protein	3418	384202	6.29	0	Nucleoplasm;Cytosol;Centrosome;Nucleus	Breast cancer;Pancreatic cancer 2;Breast-ovarian cancer, familial, 2;Fanconi anemia complementation group D1;Glioma 3	Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180).	Ubiquitinated in the absence of DNA damage; this does not lead to proteasomal degradation. In contrast, ubiquitination in response to DNA damage leads to proteasomal degradation.;Phosphorylated by ATM upon irradiation-induced DNA damage. Phosphorylation by CHEK1 and CHEK2 regulates interaction with RAD51. Phosphorylation at Ser-3291 by CDK1 and CDK2 is low in S phase when recombination is active, but increases as cells progress towards mitosis; this phosphorylation prevents homologous recombination-dependent repair during S phase and G2 by inhibiting RAD51 binding.;BRCA2 is phosphorylated by PLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Homologous recombination;Fanconi anemia pathway;Pathways in cancer;Pancreatic cancer;Meiotic recombination;HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Presynaptic phase of homologous DNA pairing and strand exchange	PE1	13
+NX_P51589	Cytochrome P450 2J2	502	57611	8.76	0	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; arachidonate metabolism.;Arachidonic acid metabolism;Linoleic acid metabolism;Metabolic pathways;Xenobiotics;Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET);Fatty acids	PE1	1
+NX_P51606	N-acylglucosamine 2-epimerase	427	48831	5.95	0	Cytoplasm;Nucleus	NA	Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.	NA	Belongs to the N-acylglucosamine 2-epimerase family.	Amino-sugar metabolism; N-acetylneuraminate degradation.;Amino sugar and nucleotide sugar metabolism;Synthesis of UDP-N-acetyl-glucosamine	PE1	X
+NX_P51608	Methyl-CpG-binding protein 2	486	52441	9.95	0	Nucleoplasm;Nucleus	Autism, X-linked 3;Mental retardation, X-linked, syndromic, Lubs type;Encephalopathy, neonatal severe, due to MECP2 mutations;Rett syndrome;Mental retardation, X-linked, syndromic, 13;Angelman syndrome	Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation.;MECP2 is phosphorylated by CDKL5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Transcriptional Regulation by MECP2;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;MECP2 regulates transcription of genes involved in GABA signaling;Loss of MECP2 binding ability to the NCoR/SMRT complex;MECP2 regulates transcription of neuronal ligands;Loss of MECP2 binding ability to 5mC-DNA;MECP2 regulates transcription factors;Loss of phosphorylation of MECP2 at T308;Loss of MECP2 binding ability to 5hmC-DNA	PE1	X
+NX_P51610	Host cell factor 1	2035	208732	7.32	0	Nucleoplasm;Cytoplasm;Mitochondrion;Nucleus	Mental retardation, X-linked 3	(Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.;Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655).	Proteolytically cleaved at one or several PPCE--THET sites within the HCF repeats. Further cleavage of the primary N- and C-terminal chains results in a 'trimming' and accumulation of the smaller chains. Cleavage is promoted by O-glycosylation.;O-glycosylated. GlcNAcylation by OGT promotes proteolytic processing.;Ubiquitinated. Lys-1807 and Lys-1808 are ubiquitinated both via 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. BAP1 mediated deubiquitination of 'Lys-48'-linked polyubiquitin chains; deubiquitination by BAP1 does not seem to stabilize the protein.	NA	Herpes simplex infection;HATs acetylate histones;Transcriptional activation of mitochondrial biogenesis;UCH proteinases	PE1	X
+NX_P51617	Interleukin-1 receptor-associated kinase 1	712	76537	6.18	0	Cytoplasm;Mitochondrion;Lipid droplet;Nucleoplasm;Cytosol;Nucleus	NA	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.	Polyubiquitinated by TRAF6 after cell stimulation with IL-1-beta by PELI1, PELI2 and PELI3. Polyubiquitination occurs with polyubiquitin chains linked through 'Lys-63'. Ubiquitination promotes interaction with NEMO/IKBKG. Also sumoylated; leading to nuclear translocation.;Following recruitment on the activated receptor complex, phosphorylated on Thr-209, probably by IRAK4, resulting in a conformational change of the kinase domain, allowing further phosphorylations to take place. Thr-387 phosphorylation in the activation loop is required to achieve full enzymatic activity.;IRAK1 is phosphorylated by AKT1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);IRAK1 is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.	Apoptosis;Toll-like receptor signaling pathway;Neurotrophin signaling pathway;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Measles;PIP3 activates AKT signaling;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;p75NTR recruits signalling complexes;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 dependent cascade initiated on endosome;MyD88 cascade initiated on plasma membrane;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;NF-kB is activated and signals survival;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-1 signaling;Transcriptional Regulation by MECP2	PE1	X
+NX_P51636	Caveolin-2	162	18291	5.06	0	Cytoplasm;Golgi apparatus;Cell membrane;Caveola;Golgi apparatus membrane;Cytoplasmic vesicle;Nucleus	NA	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).	Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).	Belongs to the caveolin family.	Endocytosis;Focal adhesion;Bacterial invasion of epithelial cells;Extra-nuclear estrogen signaling	PE1	7
+NX_P51648	Aldehyde dehydrogenase family 3 member A2	485	54848	7.98	1	Microsome membrane;Endoplasmic reticulum membrane	Sjoegren-Larsson syndrome	Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490).	NA	Belongs to the aldehyde dehydrogenase family.	Glycolysis / Gluconeogenesis;Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Lysine degradation;Arginine and proline metabolism;Histidine metabolism;Tryptophan metabolism;beta-Alanine metabolism;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis;Alpha-oxidation of phytanate;Class I peroxisomal membrane protein import;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	17
+NX_P51649	Succinate-semialdehyde dehydrogenase, mitochondrial	535	57215	8.62	0	Mitochondrion	Succinic semialdehyde dehydrogenase deficiency	Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).	NA	Belongs to the aldehyde dehydrogenase family.	Amino-acid degradation; 4-aminobutanoate degradation.;Alanine, aspartate and glutamate metabolism;Butanoate metabolism;Metabolic pathways;Degradation of GABA	PE1	6
+NX_P51654	Glypican-3	580	65563	5.96	0	Cell membrane	Simpson-Golabi-Behmel syndrome 1	Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity).	O-glycosylated; contains heparan sulfate.;Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor (PubMed:14610063). This processing is essential for its role in inhibition of hedgehog signaling (PubMed:25653284). A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface (PubMed:14610063).	Belongs to the glypican family.	Retinoid metabolism and transport;HS-GAG biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Defective B3GALT6 causes EDSP2 and SEMDJL1;Post-translational protein phosphorylation	PE1	X
+NX_P51659	Peroxisomal multifunctional enzyme type 2	736	79686	8.96	0	Peroxisome	Perrault syndrome 1;D-bifunctional protein deficiency	Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Lipid metabolism; fatty acid beta-oxidation.;Primary bile acid biosynthesis;Metabolic pathways;Peroxisome;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Beta-oxidation of pristanoyl-CoA;alpha-linolenic acid (ALA) metabolism;Beta-oxidation of very long chain fatty acids;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins	PE1	5
+NX_P51665	26S proteasome non-ATPase regulatory subunit 7	324	37025	6.29	0	Nucleoplasm	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.	NA	Belongs to the peptidase M67A family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	16
+NX_P51668	Ubiquitin-conjugating enzyme E2 D1	147	16602	6.94	0	Cytoplasm	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148).	Autoubiquitinated in vitro.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Senescence-Associated Secretory Phenotype (SASP);Signaling by BMP;Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Negative regulators of DDX58/IFIH1 signaling;IKK complex recruitment mediated by RIP1;Ovarian tumor domain proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;Neddylation;TICAM1, RIP1-mediated IKK complex recruitment;Peroxisomal protein import	PE1	10
+NX_P51671	Eotaxin	97	10732	9.98	0	Secreted	NA	In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.	O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Asthma;Interleukin-4 and Interleukin-13 signaling	PE1	17
+NX_P51674	Neuronal membrane glycoprotein M6-a	278	31210	5.17	4	Dendritic spine;Cell membrane;Growth cone;Filopodium;Neuron projection;Axon	NA	Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.	NA	Belongs to the myelin proteolipid protein family.	NA	PE1	4
+NX_P51677	C-C chemokine receptor type 3	355	41044	8.49	7	Cell membrane	NA	Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.	NA	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	3
+NX_P51679	C-C chemokine receptor type 4	360	41403	7.47	7	Cell membrane	NA	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.	In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	3
+NX_P51681	C-C chemokine receptor type 5	352	40524	9.21	7	Cell membrane	Diabetes mellitus, insulin-dependent, 22	(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.;Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation.	Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.;Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.;Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.;O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Endocytosis;Toxoplasmosis;G alpha (i) signalling events;Chemokine receptors bind chemokines;Binding and entry of HIV virion;Interleukin-10 signaling	PE1	3
+NX_P51684	C-C chemokine receptor type 6	374	42494	9.23	7	Cell surface;Cell membrane	NA	Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).	NA	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines;Beta defensins	PE1	6
+NX_P51685	C-C chemokine receptor type 8	355	40844	8.66	7	Cell membrane	NA	Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.	NA	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	3
+NX_P51686	C-C chemokine receptor type 9	369	42016	8.54	7	Cell membrane	NA	Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.;(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.	NA	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Intestinal immune network for IgA production;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	3
+NX_P51687	Sulfite oxidase, mitochondrial	545	60283	5.72	0	Mitochondrion intermembrane space	Sulfite oxidase deficiency, isolated	NA	NA	NA	Energy metabolism; sulfur metabolism.;Sulfur metabolism;Sulfide oxidation to sulfate	PE1	12
+NX_P51688	N-sulphoglucosamine sulphohydrolase	502	56695	6.46	0	Lysosome	Mucopolysaccharidosis 3A	Catalyzes a step in lysosomal heparan sulfate degradation.	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Glycosaminoglycan degradation;Metabolic pathways;Lysosome;HS-GAG degradation;MPS IIIA - Sanfilippo syndrome A	PE1	17
+NX_P51689	Arylsulfatase D	593	64860	6.78	0	Cytoplasmic vesicle;Lipid droplet;Lysosome	NA	NA	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Glycosphingolipid metabolism;The activation of arylsulfatases	PE1	X
+NX_P51690	Arylsulfatase E	589	65669	6.48	0	Golgi apparatus;Golgi stack	Chondrodysplasia punctata 1, X-linked recessive	May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates.	N-glycosylated.;The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Glycosphingolipid metabolism;The activation of arylsulfatases	PE1	X
+NX_P51692	Signal transducer and activator of transcription 5B	787	89866	5.71	0	Cytoplasm;Nucleus	Growth hormone insensitivity with immunodeficiency	Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.	Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.	Belongs to the transcription factor STAT family.	ErbB signaling pathway;Chemokine signaling pathway;Jak-STAT signaling pathway;Measles;HTLV-I infection;Pathways in cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Interleukin-7 signaling;Prolactin receptor signaling;Growth hormone receptor signaling;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Interleukin-3, Interleukin-5 and GM-CSF signaling;Signaling by Leptin;Downstream signal transduction;Interleukin-20 family signaling;Interleukin-15 signaling;Interleukin-9 signaling;Interleukin-2 signaling;Interleukin-21 signaling;Erythropoietin activates STAT5;STAT5 Activation	PE1	17
+NX_P51693	Amyloid-like protein 1	650	72176	5.54	1	Cytoplasm;Cell membrane	NA	May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.;The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.	Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By similarity).;N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228.	Belongs to the APP family.	NA	PE1	19
+NX_P51784	Ubiquitin carboxyl-terminal hydrolase 11	963	109817	5.28	0	Cytoplasm;Nucleoplasm;Nucleus;Chromosome	NA	Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937).	NA	Belongs to the peptidase C19 family.	Association of TriC/CCT with target proteins during biosynthesis;Ub-specific processing proteases	PE1	X
+NX_P51786	Zinc finger protein 157	506	58291	8.83	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	X
+NX_P51787	Potassium voltage-gated channel subfamily KQT member 1	676	74699	9.88	6	Cell membrane;Basolateral cell membrane;Early endosome;Endoplasmic reticulum;Cytoplasmic vesicle membrane;Membrane raft	Jervell and Lange-Nielsen syndrome 1;Long QT syndrome 1;Diabetes mellitus, non-insulin-dependent;Short QT syndrome 2;Atrial fibrillation, familial, 3	Non-functional alone but modulatory when coexpressed with the full-length isoform 1.;Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity) (PubMed:10646604). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:19687231). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568).	Deubiquitinated by USP2; counteracts the NEDD4L-specific down-regulation of I(Ks) and restores the membrane localization.;Ubiquitinated by NEDD4L; promotes internalization (PubMed:22024150). The ubiquitinylated form is internalized through a clathrin-mediated endocytosis by interacting with AP2M1 and is recycled back to the cell membrane via RAB4A and RAB11A (PubMed:23529131).;Phosphorylation at Ser-27 by PKA; increases delayed rectifier potassium channel activity of the KCNQ1-KCNE1 complex through a macromolecular complex that includes PKA, PP1, and the targeting protein AKAP9.	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.	Cholinergic synapse;Gastric acid secretion;Pancreatic secretion;Protein digestion and absorption;Vibrio cholerae infection;Voltage gated Potassium channels;Phase 3 - rapid repolarisation;Phase 2 - plateau phase	PE1	11
+NX_P51788	Chloride channel protein 2	898	98535	8.7	10	Cytosol;Cell membrane	Juvenile myoclonic epilepsy 8;Juvenile absence epilepsy 2;Epilepsy, idiopathic generalized 11;Hyperaldosteronism, familial, 2;Leukoencephalopathy with ataxia	Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012).	Phosphorylated. Activated by dephosphorylation.	Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.	Mineral absorption;Stimuli-sensing channels	PE1	3
+NX_P51790	H(+)/Cl(-) exchange transporter 3	818	90966	5.88	10	Endoplasmic reticulum;Secretory vesicle membrane;Golgi apparatus membrane;Early endosome membrane;Cytoplasmic vesicle;Late endosome membrane	NA	Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.	N-glycosylated.	Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.	Stimuli-sensing channels	PE1	4
+NX_P51793	H(+)/Cl(-) exchange transporter 4	760	84917	6.43	10	Early endosome membrane;Cytoplasmic vesicle;Endoplasmic reticulum membrane;Late endosome membrane	Raynaud-Claes syndrome	Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.	NA	Belongs to the chloride channel (TC 2.A.49) family. ClC-4/CLCN4 subfamily.	Stimuli-sensing channels	PE1	X
+NX_P51795	H(+)/Cl(-) exchange transporter 5	746	83147	6.37	10	Golgi apparatus;Cell membrane;Endosome membrane;Golgi apparatus membrane;Cytosol	Nephrolithiasis 2;Low molecular weight proteinuria with hypercalciuria and nephrocalcinosis;Nephrolithiasis 1;Hypophosphatemic rickets, X-linked recessive	Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.	Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation.	Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.	Stimuli-sensing channels	PE1	X
+NX_P51797	Chloride transport protein 6	869	97289	6.39	10	Cytosol;Endosome membrane;Cell membrane	NA	Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.	N-glycosylated on several asparagine residues.	Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily.	Stimuli-sensing channels;Signaling by BRAF and RAF fusions	PE1	1
+NX_P51798	H(+)/Cl(-) exchange transporter 7	805	88679	8.66	10	Nucleoplasm;Lysosome membrane	Osteopetrosis, autosomal recessive 4;Osteopetrosis, autosomal dominant 2	Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen.	NA	Belongs to the chloride channel (TC 2.A.49) family. ClC-7/CLCN7 subfamily.	Stimuli-sensing channels	PE1	16
+NX_P51800	Chloride channel protein ClC-Ka	687	75285	7.62	10	Membrane	Bartter syndrome 4B, neonatal, with sensorineural deafness	Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.	NA	Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily.	Stimuli-sensing channels	PE1	1
+NX_P51801	Chloride channel protein ClC-Kb	687	75446	8.2	10	Cell membrane	Bartter syndrome 4B, neonatal, with sensorineural deafness;Bartter syndrome 3	Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.	NA	Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.	Collecting duct acid secretion;Stimuli-sensing channels	PE1	1
+NX_P51805	Plexin-A3	1871	207703	7.06	1	Cytoplasmic vesicle;Nucleoplasm;Cell membrane	NA	Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.	NA	Belongs to the plexin family.	Axon guidance;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Sema3A PAK dependent Axon repulsion;CRMPs in Sema3A signaling	PE1	X
+NX_P51808	Dynein light chain Tctex-type 3	116	13062	5.37	0	Nucleus;Kinetochore;Cytoskeleton	NA	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).	NA	Belongs to the dynein light chain Tctex-type family.	NA	PE1	X
+NX_P51809	Vesicle-associated membrane protein 7	220	24935	8.86	1	Endoplasmic reticulum membrane;Synaptosome;Phagosome membrane;Lysosome membrane;trans-Golgi network membrane;Secretory vesicle membrane;Cytoplasmic vesicle;Late endosome membrane	NA	Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.	NA	Belongs to the synaptobrevin family.	SNARE interactions in vesicular transport;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Interleukin-12 signaling;trans-Golgi Network Vesicle Budding	PE1	X
+NX_P51810	G-protein coupled receptor 143	404	43878	7.53	7	Apical cell membrane;Lysosome membrane;Melanosome membrane	Nystagmus congenital X-linked 6;Albinism ocular 1	Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.	Phosphorylated.;Glycosylated.	Belongs to the G-protein coupled receptor OA family.	G alpha (q) signalling events;Amine ligand-binding receptors	PE1	X
+NX_P51811	Membrane transport protein XK	444	50902	8.6	10	Membrane;Nucleoplasm;Mitochondrion;Cytoplasmic vesicle	McLeod syndrome	May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.	Not glycosylated.	Belongs to the XK family.	Peptide ligand-binding receptors	PE1	X
+NX_P51812	Ribosomal protein S6 kinase alpha-3	740	83736	6.41	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	Coffin-Lowry syndrome;Mental retardation, X-linked 19	Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3. Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1. Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).	N-terminal myristoylation results in an activated kinase in the absence of added growth factors.;Activated by phosphorylation at Ser-227 by PDPK1. Autophosphorylated on Ser-386, as part of the activation process. May be phosphorylated at Thr-365 and Ser-369 by MAPK1/ERK2 and MAPK3/ERK1. Can also be activated via phosphorylation at Ser-386 by MAPKAPK2.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	MAPK signaling pathway;Oocyte meiosis;mTOR signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Progesterone-mediated oocyte maturation;Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK;ERK/MAPK targets;CREB phosphorylation	PE1	X
+NX_P51813	Cytoplasmic tyrosine-protein kinase BMX	675	78011	8.7	0	Cytoplasm;Nucleoplasm;Cell membrane	NA	Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.	Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis leads to activation and is required for STAT3 phosphorylation by BMX.;BMX is phosphorylated by KDR (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.	Synthesis of PIPs at the plasma membrane;Apoptotic cleavage of cellular proteins	PE1	X
+NX_P51814	Zinc finger protein 41	821	93728	9.06	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	X
+NX_P51815	Zinc finger protein 75D	510	59298	9.35	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	X
+NX_P51816	AF4/FMR2 family member 2	1311	144771	8.23	0	Nucleus speckle	Mental retardation, X-linked, associated with fragile site FRAXE	RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.	NA	Belongs to the AF4 family.	NA	PE1	X
+NX_P51817	cAMP-dependent protein kinase catalytic subunit PRKX	358	40896	6.37	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.	Phosphorylated; autophosphorylates in vitro.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.	MAPK signaling pathway;Calcium signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Apoptosis;Vascular smooth muscle contraction;Wnt signaling pathway;Hedgehog signaling pathway;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Olfactory transduction;Taste transduction;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;PKA-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of Adenylate Cyclase	PE1	X
+NX_P51825	AF4/FMR2 family member 1	1210	131422	9.26	0	Nucleoplasm;Mitochondrion;Nucleus	NA	NA	NA	Belongs to the AF4 family.	NA	PE1	4
+NX_P51826	AF4/FMR2 family member 3	1226	133503	8.35	0	Nucleoplasm;Cytosol;Nucleus	NA	Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.	NA	Belongs to the AF4 family.	NA	PE1	2
+NX_P51828	Adenylate cyclase type 7	1080	120308	8.49	12	Membrane;Cytosol	NA	Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity).	Phosphorylated by PRKCD.	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Calcium signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;HTLV-I infection;Dilated cardiomyopathy;G alpha (i) signalling events;G alpha (s) signalling events;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G alpha (z) signalling events;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway	PE1	16
+NX_P51841	Retinal guanylyl cyclase 2	1108	124850	6.87	1	Photoreceptor outer segment membrane	NA	Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:7777544). Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).	There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Phototransduction;Inactivation, recovery and regulation of the phototransduction cascade	PE1	X
+NX_P51843	Nuclear receptor subfamily 0 group B member 1	470	51718	8.47	0	Cytoplasm;Nucleus speckle;Centriolar satellite;Cytoplasmic vesicle;Nucleus	46,XY sex reversal 2;Adrenal hypoplasia, congenital	Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).	NA	Belongs to the nuclear hormone receptor family. NR0 subfamily.	Nuclear Receptor transcription pathway	PE1	X
+NX_P51854	Transketolase-like protein 1	596	65333	5.56	0	Cytoplasm;Cytosol;Nucleus	NA	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	NA	Belongs to the transketolase family.	Pentose phosphate pathway;Metabolic pathways	PE1	X
+NX_P51857	Aldo-keto reductase family 1 member D1	326	37377	7.14	0	Cytoplasm;Nucleoplasm;Cytosol	Congenital bile acid synthesis defect 2	Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one).	NA	Belongs to the aldo/keto reductase family.	Primary bile acid biosynthesis;Steroid hormone biosynthesis;Metabolic pathways;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol	PE1	7
+NX_P51858	Hepatoma-derived growth factor	240	26788	4.7	0	Extracellular exosome;Cytoplasm;Nucleoplasm;Nucleus	NA	Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618).;Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719).;Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719).	Sumoylated with SUMO1. Sumoylation prevents binding to chromatin.;Phosphorylation at Ser-165 is likely to be required for secretion.	Belongs to the HDGF family.	XBP1(S) activates chaperone genes	PE1	1
+NX_P51861	Cerebellar degeneration-related antigen 1	262	31279	4.35	0	Golgi apparatus;Nucleoplasm;Centrosome	NA	NA	NA	NA	NA	PE1	X
+NX_P51864	Putative teratocarcinoma-derived growth factor 3	188	21181	8.2	0	Cell membrane	NA	Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Activates the Nodal-dependent signaling pathway.	NA	Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.	Signaling by NODAL;Regulation of signaling by NODAL	PE5	X
+NX_P51878	Caspase-5	434	49736	9.28	0	NA	NA	Mediator of programmed cell death (apoptosis). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).	The two subunits are derived from the precursor sequence by an autocatalytic mechanism.	Belongs to the peptidase C14A family.	NOD-like receptor signaling pathway	PE1	11
+NX_P51884	Lumican	338	38429	6.16	0	Extracellular matrix	NA	NA	Sulfated on tyrosine residue(s).	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Keratan sulfate biosynthesis;Defective CHST6 causes MCDC1;Keratan sulfate degradation;Defective B4GALT1 causes B4GALT1-CDG (CDG-2d);Integrin cell surface interactions;ECM proteoglycans;Defective ST3GAL3 causes MCT12 and EIEE15	PE1	12
+NX_P51888	Prolargin	382	43810	9.47	0	Extracellular matrix	NA	May anchor basement membranes to the underlying connective tissue.	NA	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Keratan sulfate biosynthesis;Defective CHST6 causes MCDC1;Keratan sulfate degradation;Defective B4GALT1 causes B4GALT1-CDG (CDG-2d);Defective ST3GAL3 causes MCT12 and EIEE15	PE1	1
+NX_P51911	Calponin-1	297	33170	9.14	0	Cytoskeleton	NA	Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).	NA	Belongs to the calponin family.	NA	PE1	19
+NX_P51946	Cyclin-H	323	37643	6.73	0	Nucleoplasm;Nucleus	NA	Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.	NA	Belongs to the cyclin family. Cyclin C subfamily.	Basal transcription factors;Nucleotide excision repair;Cell cycle;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Tat-mediated elongation of the HIV-1 transcript;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Cyclin E associated events during G1/S transition;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A:Cdk2-associated events at S phase entry;Cyclin D associated events in G1;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Formation of Incision Complex in GG-NER;TP53 Regulates Transcription of DNA Repair Genes;RUNX1 regulates transcription of genes involved in differentiation of HSCs	PE1	5
+NX_P51948	CDK-activating kinase assembly factor MAT1	309	35823	5.79	0	Nucleoplasm;Nucleus	NA	Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.	NA	NA	Basal transcription factors;Nucleotide excision repair;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Tat-mediated elongation of the HIV-1 transcript;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Cyclin E associated events during G1/S transition;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A:Cdk2-associated events at S phase entry;Cyclin D associated events in G1;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Formation of Incision Complex in GG-NER;TP53 Regulates Transcription of DNA Repair Genes;RUNX1 regulates transcription of genes involved in differentiation of HSCs	PE1	14
+NX_P51955	Serine/threonine-protein kinase Nek2	445	51763	9.03	0	Cytoplasm;Nucleolus;Nucleoplasm;Centromere;Spindle pole;Centrosome;Nucleus;Kinetochore	Retinitis pigmentosa 67	Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells.;Phosphorylates and activates NEK11 in G1/S-arrested cells.;Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856).	Activated by autophosphorylation. Protein phosphatase 1 represses autophosphorylation and activation of isoform 1 by dephosphorylation. Phosphorylation by STK3/MST2 is necessary for its localization to the centrosome.;NEK2 is phosphorylated by RPS6KA3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);NEK2 is phosphorylated by PLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;APC-Cdc20 mediated degradation of Nek2A;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	1
+NX_P51956	Serine/threonine-protein kinase Nek3	506	57705	6.72	0	Cytoplasm;Axon;Cytoskeleton	NA	Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.	Phosphorylation at Thr-479 regulates its catalytic activity.	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	NA	PE1	13
+NX_P51957	Serine/threonine-protein kinase Nek4	841	94597	8.04	0	Cytoplasm;Cytosol;Cilium	NA	Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.	NA	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	NA	PE1	3
+NX_P51959	Cyclin-G1	295	34074	9.06	0	Nucleoplasm;Nucleus	NA	May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).	NA	Belongs to the cyclin family. Cyclin G subfamily.	p53 signaling pathway;Regulation of TP53 Degradation	PE1	5
+NX_P51965	Ubiquitin-conjugating enzyme E2 E1	193	21404	8.77	0	Nucleoplasm;Nucleus	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.	ISGylation suppresses ubiquitin E2 enzyme activity.;Autoubiquitinated in vitro.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;ISG15 antiviral mechanism;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins	PE1	3
+NX_P51970	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	172	20105	7.58	0	Mitochondrion intermembrane space;Mitochondrion inner membrane;Mitochondrion	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	May contain intrachain disulfide bonds, as evidenced by its electrophoretic mobility under reducing vs non-reducing conditions.	Belongs to the complex I NDUFA8 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	9
+NX_P51991	Heterogeneous nuclear ribonucleoprotein A3	378	39595	9.1	0	Nucleus	NA	Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.	NA	NA	Spliceosome;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA	PE1	2
+NX_P51993	Alpha-(1,3)-fucosyltransferase 6	359	41860	8.92	1	Golgi stack membrane;Golgi apparatus	NA	Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.	NA	Belongs to the glycosyltransferase 10 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Lewis blood group biosynthesis	PE1	19
+NX_P52179	Myomesin-1	1685	187627	6.5	0	M line	NA	Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.	NA	NA	NA	PE1	18
+NX_P52198	Rho-related GTP-binding protein RhoN	227	25369	8.66	0	Acrosome membrane	NA	May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).	NA	Belongs to the small GTPase superfamily. Rho family.	NA	PE1	17
+NX_P52209	6-phosphogluconate dehydrogenase, decarboxylating	483	53140	6.8	0	Cytoplasm;Cytosol;Cytoskeleton	NA	Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.	NA	Belongs to the 6-phosphogluconate dehydrogenase family.	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.;Pentose phosphate pathway;Glutathione metabolism;Metabolic pathways;Pentose phosphate pathway	PE1	1
+NX_P52272	Heterogeneous nuclear ribonucleoprotein M	730	77516	8.84	0	Nucleoplasm;Nucleolus;Nucleus	NA	Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.	Sumoylated.	NA	Spliceosome;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;FGFR2 alternative splicing	PE1	19
+NX_P52292	Importin subunit alpha-1	529	57862	5.25	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.	KPNA2 is phosphorylated by MAPK3;KPNA2 is phosphorylated by ITK (Phosphotyrosine:PTM-0255)	Belongs to the importin alpha family.	Influenza A;ISG15 antiviral mechanism;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CaMK IV-mediated phosphorylation of CREB;NS1 Mediated Effects on Host Pathways;Sensing of DNA Double Strand Breaks;Estrogen-dependent gene expression	PE1	17
+NX_P52294	Importin subunit alpha-5	538	60222	4.94	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.	Polyubiquitinated in the presence of RAG1 (in vitro).	Belongs to the importin alpha family.	Influenza A;ISG15 antiviral mechanism;Vpr-mediated nuclear import of PICs;Integration of provirus;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Apoptosis induced DNA fragmentation	PE1	3
+NX_P52298	Nuclear cap-binding protein subunit 2	156	18001	8.34	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858).	NA	Belongs to the RRM NCBP2 family.	RNA transport;mRNA surveillance pathway;Spliceosome;snRNP Assembly;SLBP independent Processing of Histone Pre-mRNAs;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing;Processing of Capped Intron-Containing Pre-mRNA;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;Processing of Intronless Pre-mRNAs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;Regulation of expression of SLITs and ROBOs;RNA Polymerase II Transcription Termination	PE1	3
+NX_P52306	Rap1 GTPase-GDP dissociation stimulator 1	607	66317	5.17	0	Cytosol	NA	Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.	NA	NA	NA	PE1	4
+NX_P52333	Tyrosine-protein kinase JAK3	1124	125099	6.77	0	Cytoplasm;Cytosol;Endomembrane system;Cell membrane	Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.	Tyrosine phosphorylated in response to IL-2 and IL-4. Dephosphorylation of Tyr-980 and Tyr-981 by PTPN2 negatively regulates cytokine-mediated signaling (Probable).	Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.	Chemokine signaling pathway;Jak-STAT signaling pathway;Measles;HTLV-I infection;Primary immunodeficiency;RAF/MAP kinase cascade;Interleukin-7 signaling;Interleukin receptor SHC signaling;Interleukin-20 family signaling;Interleukin-4 and Interleukin-13 signaling;Interleukin-15 signaling;Interleukin-9 signaling;Interleukin-2 signaling;Interleukin-21 signaling	PE1	19
+NX_P52429	Diacylglycerol kinase epsilon	567	63927	8.02	2	Membrane;Nucleoplasm;Cytosol;Cytoplasm	Nephrotic syndrome 7;Hemolytic uremic syndrome atypical 7	Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.	NA	Belongs to the eukaryotic diacylglycerol kinase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Effects of PIP2 hydrolysis	PE1	17
+NX_P52434	DNA-directed RNA polymerases I, II, and III subunit RPABC3	150	17143	4.5	0	Nucleoplasm;Nucleolus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	NA	Belongs to the eukaryotic RPB8 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Huntington's disease;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Cytosolic sensors of pathogen-associated DNA;MicroRNA (miRNA) biogenesis;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	3
+NX_P52435	DNA-directed RNA polymerase II subunit RPB11-a	117	13293	5.63	0	Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).	NA	Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Huntington's disease;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;MicroRNA (miRNA) biogenesis;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	7
+NX_P52564	Dual specificity mitogen-activated protein kinase kinase 6	334	37492	7.01	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.	Weakly autophosphorylated. Phosphorylated at Ser-207 and Thr-211 by the majority of M3Ks, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2.;Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.;MAP2K6 is phosphorylated by MAP3K3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K6 is phosphorylated by MAP3K7 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K6 is phosphorylated by LRRK2;MAP2K6 is phosphorylated by MAP3K4 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K6 is phosphorylated by MAP3K2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K6 is phosphorylated by MAP3K5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	MAPK signaling pathway;Osteoclast differentiation;Toll-like receptor signaling pathway;Fc epsilon RI signaling pathway;GnRH signaling pathway;Amyotrophic lateral sclerosis (ALS);Toxoplasmosis;Influenza A;NOD1/2 Signaling Pathway;Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;Uptake and function of anthrax toxins;PI5P Regulates TP53 Acetylation;Interleukin-1 signaling;Myogenesis	PE1	17
+NX_P52565	Rho GDP-dissociation inhibitor 1	204	23207	5.03	0	Cytoplasm;Cytosol	Nephrotic syndrome 8	Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.	ARHGDIA is phosphorylated by FER;ARHGDIA is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the Rho GDI family.	Neurotrophin signaling pathway;Vasopressin-regulated water reabsorption;Axonal growth inhibition (RHOA activation);Rho GTPase cycle;Axonal growth stimulation	PE1	17
+NX_P52566	Rho GDP-dissociation inhibitor 2	201	22988	5.1	0	Cytosol	NA	Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).	NA	Belongs to the Rho GDI family.	Neurotrophin signaling pathway;Vasopressin-regulated water reabsorption;Rho GTPase cycle	PE1	12
+NX_P52569	Cationic amino acid transporter 2	658	71673	7.01	14	Cell junction;Cell membrane	NA	Functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport.;Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing.;Functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2.	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.	Amino acid transport across the plasma membrane	PE1	8
+NX_P52594	Arf-GAP domain and FG repeat-containing protein 1	562	58260	8.82	0	Cytoplasmic vesicle;Nucleus	NA	Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.	O-glycosylated.	NA	Influenza A;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	2
+NX_P52597	Heterogeneous nuclear ribonucleoprotein F	415	45672	5.38	0	Nucleoplasm	NA	Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.	Sumoylated.	NA	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;FGFR2 alternative splicing;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	10
+NX_P52630	Signal transducer and activator of transcription 2	851	97916	5.34	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	Immunodeficiency 44	Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).	Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response.;'Lys-48'-linked ubiquitination by DCST1 leads to STAT2 proteasomal degradation.	Belongs to the transcription factor STAT family.	Chemokine signaling pathway;Osteoclast differentiation;Jak-STAT signaling pathway;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Interferon alpha/beta signaling;Regulation of IFNA signaling;Interleukin-20 family signaling	PE1	12
+NX_P52655	Transcription initiation factor IIA subunit 1	376	41514	4.4	0	Nucleoplasm;Cytosol;Nucleus	NA	TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.	The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation.	Belongs to the TFIIA subunit 1 family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA polymerase II transcribes snRNA genes;Estrogen-dependent gene expression	PE1	14
+NX_P52657	Transcription initiation factor IIA subunit 2	109	12457	6.26	0	Nucleoplasm;Nucleus	NA	TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.	NA	Belongs to the TFIIA subunit 2 family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA polymerase II transcribes snRNA genes;Estrogen-dependent gene expression	PE1	15
+NX_P52701	DNA mismatch repair protein Msh6	1360	152786	6.5	0	Golgi apparatus;Chromosome;Nucleoplasm;Cytoplasmic vesicle;Nucleus	Endometrial cancer;Hereditary non-polyposis colorectal cancer 5;Colorectal cancer;Mismatch repair cancer syndrome	Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.	The N-terminus is blocked.;Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.;MSH6 is phosphorylated by PRKCZ (Phosphothreonine:PTM-0254)	Belongs to the DNA mismatch repair MutS family.	Mismatch repair;Pathways in cancer;Colorectal cancer;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Defective Mismatch Repair Associated With MSH2;Defective Mismatch Repair Associated With MSH6	PE1	2
+NX_P52732	Kinesin-like protein KIF11	1056	119159	5.47	0	Cytoplasm;Spindle pole;Spindle;Cytosol	Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation	Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).	A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.;Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase).	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.	MHC class II antigen presentation;Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	10
+NX_P52735	Guanine nucleotide exchange factor VAV2	878	101289	6.67	0	Cytoplasmic vesicle	NA	Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).	Phosphorylated on tyrosine residues in response to FGR activation.	NA	Chemokine signaling pathway;Focal adhesion;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Regulation of actin dynamics for phagocytic cup formation;GPVI-mediated activation cascade;EPH-ephrin mediated repulsion of cells;Rho GTPase cycle;NRAGE signals death through JNK;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;G alpha (12/13) signalling events;VEGFA-VEGFR2 Pathway;Signal transduction by L1;VEGFR2 mediated vascular permeability	PE1	9
+NX_P52736	Zinc finger protein 133	654	73388	9.26	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	May be involved in transcriptional regulation as a repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	20
+NX_P52737	Zinc finger protein 136	540	62784	9.32	0	Nucleolus;Nucleus	NA	May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_P52738	Zinc finger protein 140	457	52996	8.95	0	Nucleus	NA	May be involved in transcriptional regulation as a repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	12
+NX_P52739	Zinc finger protein 131	623	71422	5.1	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.	Ubiquitinated.;Monosumoylated at Lys-601 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination.	Belongs to the krueppel C2H2-type zinc-finger protein family.	SUMOylation of transcription cofactors	PE1	5
+NX_P52740	Zinc finger protein 132	706	80623	8.77	0	Cytoplasmic vesicle;Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P52741	Zinc finger protein 134	427	48480	8.96	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P52742	Zinc finger protein 135	658	75261	8.49	0	Cytosol;Nucleus	NA	Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_P52743	Putative zinc finger protein 137	207	24115	9.77	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE5	19
+NX_P52744	Zinc finger protein 138	262	30592	9.63	0	Nucleus	NA	May be involved in transcriptional regulation as a repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_P52746	Zinc finger protein 142	1687	187880	8.24	0	Nucleoplasm;Nucleolus;Nucleus	Neurodevelopmental disorder with impaired speech and hyperkinetic movements	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	2
+NX_P52747	Zinc finger protein 143	638	68896	5.64	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.	NA	Belongs to the GLI C2H2-type zinc-finger protein family.	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA polymerase II transcribes snRNA genes	PE1	11
+NX_P52756	RNA-binding protein 5	815	92154	5.94	0	Nucleoplasm;Nucleus	NA	Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.	NA	Belongs to the RBM5/RBM10 family.	mRNA Splicing - Major Pathway	PE1	3
+NX_P52757	Beta-chimaerin	468	53924	7.04	0	Membrane;Nucleoplasm	NA	GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.	NA	NA	Rho GTPase cycle	PE1	7
+NX_P52758	2-iminobutanoate/2-iminopropanoate deaminase	137	14494	8.73	0	Peroxisome;Cytoplasm;Mitochondrion;Nucleus	NA	Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.;Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex (PubMed:8973653, PubMed:30930054). Acts by bridging YTHDF2 and the ribonuclease P/MRP complex (PubMed:30930054). RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage (PubMed:30930054).	NA	Belongs to the RutC family.	Threonine catabolism	PE1	8
+NX_P52788	Spermine synthase	366	41268	4.87	0	Cytoplasm;Cytosol;Nucleus	X-linked syndromic mental retardation Snyder-Robinson type	Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).	NA	Belongs to the spermidine/spermine synthase family.	Amine and polyamine biosynthesis; spermine biosynthesis; spermine from spermidine: step 1/1.;Cysteine and methionine metabolism;Arginine and proline metabolism;beta-Alanine metabolism;Glutathione metabolism;Metabolic pathways;Metabolism of polyamines	PE1	X
+NX_P52789	Hexokinase-2	917	102380	5.71	0	Mitochondrion outer membrane;Cytosol;Mitochondrion	NA	Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175).	NA	Belongs to the hexokinase family.	Carbohydrate metabolism; hexose metabolism.;Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.;Glycolysis / Gluconeogenesis;Fructose and mannose metabolism;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Butirosin and neomycin biosynthesis;Metabolic pathways;Insulin signaling pathway;Type II diabetes mellitus;Carbohydrate digestion and absorption;Glycolysis	PE1	2
+NX_P52790	Hexokinase-3	923	99025	5.23	0	NA	NA	Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:8717435). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435).	NA	Belongs to the hexokinase family.	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.;Carbohydrate metabolism; hexose metabolism.;Glycolysis / Gluconeogenesis;Fructose and mannose metabolism;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Butirosin and neomycin biosynthesis;Metabolic pathways;Insulin signaling pathway;Type II diabetes mellitus;Carbohydrate digestion and absorption;Glycolysis;Neutrophil degranulation	PE1	5
+NX_P52797	Ephrin-A3	238	26350	8.85	0	Cell membrane	NA	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).	NA	Belongs to the ephrin family.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	1
+NX_P52798	Ephrin-A4	201	22386	6.89	0	Secreted;Cell membrane	NA	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.	NA	Belongs to the ephrin family.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	1
+NX_P52799	Ephrin-B2	333	36923	9.04	1	Nucleoplasm;Cytosol;Adherens junction;Cell membrane	NA	(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.;Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.	Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.	Belongs to the ephrin family.	Axon guidance;EPH-Ephrin signaling;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells	PE1	13
+NX_P52803	Ephrin-A5	228	26297	5.97	0	Cytoplasmic vesicle;Cytosol;Caveola;Cell membrane	NA	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.	NA	Belongs to the ephrin family.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	5
+NX_P52815	39S ribosomal protein L12, mitochondrial	198	21348	9.05	0	Mitochondrion	NA	Associates with mitochondrial RNA polymerase to activate transcription.	NA	Belongs to the bacterial ribosomal protein bL12 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	17
+NX_P52823	Stanniocalcin-1	247	27621	8.28	0	Secreted	NA	Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.	NA	Belongs to the stanniocalcin family.	NA	PE1	8
+NX_P52824	Diacylglycerol kinase theta	942	101155	7.35	0	Cytoplasm;Nucleus speckle;Cell membrane;Nucleus;Cytoskeleton	NA	Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity.	Phosphorylated by PRKCE and PRKCH in vitro.;DGKQ is phosphorylated by PRKCE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the eukaryotic diacylglycerol kinase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Effects of PIP2 hydrolysis	PE1	4
+NX_P52848	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1	882	100868	8.07	1	Golgi apparatus membrane	Mental retardation, autosomal recessive 46	Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:10758005, PubMed:12634318). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (PubMed:10758005, PubMed:12634318). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).	NA	Belongs to the sulfotransferase 1 family. NDST subfamily.	Glycan metabolism; heparin biosynthesis.;Glycan metabolism; heparan sulfate biosynthesis.;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;HS-GAG biosynthesis	PE1	5
+NX_P52849	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2	883	100875	8.81	1	Cytosol;Golgi apparatus membrane	NA	Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).	NA	Belongs to the sulfotransferase 1 family. NDST subfamily.	Glycan metabolism; heparan sulfate biosynthesis.;Glycan metabolism; heparin biosynthesis.;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;HS-GAG biosynthesis	PE1	10
+NX_P52888	Thimet oligopeptidase	689	78840	5.72	0	Cytoplasm;Cytosol	NA	Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.	NA	Belongs to the peptidase M3 family.	Renin-angiotensin system;African trypanosomiasis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	19
+NX_P52895	Aldo-keto reductase family 1 member C2	323	36735	7.13	0	Cytoplasm	46,XY sex reversal 8	Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.	NA	Belongs to the aldo/keto reductase family.	Steroid hormone biosynthesis;Metabolism of xenobiotics by cytochrome P450;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol	PE1	10
+NX_P52907	F-actin-capping protein subunit alpha-1	286	32923	5.45	0	Cytoplasm;Cytoskeleton	NA	F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.	NA	Belongs to the F-actin-capping protein alpha subunit family.	MHC class II antigen presentation;Factors involved in megakaryocyte development and platelet production;Advanced glycosylation endproduct receptor signaling;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;HSP90 chaperone cycle for steroid hormone receptors (SHR);Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	1
+NX_P52926	High mobility group protein HMGI-C	109	11832	10.63	0	Nucleoplasm;Nucleolus;Nucleus	NA	Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity).	Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity. Phosphorylated by NEK2 (By similarity).;HMGA2 is phosphorylated by CDK1;HMGA2 is phosphorylated by NEK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the HMGA family.	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	PE1	12
+NX_P52943	Cysteine-rich protein 2	208	22493	9.01	0	Nucleoplasm;Nucleolus;Cell membrane	NA	NA	NA	NA	NA	PE1	14
+NX_P52945	Pancreas/duodenum homeobox protein 1	283	30771	7.1	0	Nucleoplasm;Cytosol;Nucleus	Diabetes mellitus, non-insulin-dependent;Maturity-onset diabetes of the young 4;Pancreatic agenesis 1	Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.	Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol (By similarity).	Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.	Type II diabetes mellitus;Maturity onset diabetes of the young;Regulation of gene expression in beta cells;Regulation of gene expression in early pancreatic precursor cells	PE1	13
+NX_P52948	Nuclear pore complex protein Nup98-Nup96	1817	197579	5.97	0	Nucleoplasm;Nuclear pore complex;Nucleus membrane;Cytoplasmic vesicle	NA	Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134).	To isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively (PubMed:10087256, PubMed:20407419, PubMed:12191480, PubMed:18287282). Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96 (PubMed:20407419, PubMed:12191480).;Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation.;NUP98 is phosphorylated by NEK7 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the nucleoporin GLFG family.	RNA transport;Influenza A;Separation of Sister Chromatids;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	11
+NX_P52951	Homeobox protein GBX-2	348	37348	8.43	0	Nucleoplasm;Nucleus	NA	May act as a transcription factor for cell pluripotency and differentiation in the embryo.	NA	NA	NA	PE1	2
+NX_P52952	Homeobox protein Nkx-2.5	324	34918	9.46	0	Nucleoplasm;Cytosol;Nucleus	Atrial septal defect 7, with or without atrioventricular conduction defects;Conotruncal heart malformations;Ventricular septal defect 3;Tetralogy of Fallot;Hypoplastic left heart syndrome 2;Hypothyroidism, congenital, non-goitrous, 5	Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development.	NA	Belongs to the NK-2 homeobox family.	YAP1- and WWTR1 (TAZ)-stimulated gene expression;Physiological factors	PE1	5
+NX_P52954	Transcription factor LBX1	281	30221	6.47	0	Nucleoplasm;Nucleus	NA	Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.	NA	NA	NA	PE1	10
+NX_P52961	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	327	36335	8.53	0	Sarcoplasmic reticulum membrane	NA	Has ADP-ribosyltransferase activity toward GLP1R.	NA	Belongs to the Arg-specific ADP-ribosyltransferase family.	Alpha-defensins	PE2	11
+NX_P53004	Biliverdin reductase A	296	33428	6.06	0	Cytoplasm;Cytosol	Hyperbiliverdinemia	Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.	BLVRA is phosphorylated by PRKCB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.	Porphyrin-containing compound metabolism; protoheme degradation.;Porphyrin and chlorophyll metabolism;Heme degradation	PE1	7
+NX_P53007	Tricarboxylate transport protein, mitochondrial	311	34013	9.91	6	Mitochondrion inner membrane	Combined D-2- and L-2-hydroxyglutaric aciduria;Myasthenic syndrome, congenital, 23, presynaptic	Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate (PubMed:29031613, PubMed:29238895). Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate (PubMed:29031613). Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Gluconeogenesis;Fatty acyl-CoA biosynthesis	PE1	22
+NX_P53041	Serine/threonine-protein phosphatase 5	499	56879	5.88	0	Cytoplasm;Cell membrane;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.	Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form.	Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.	MAPK signaling pathway;Negative regulation of MAPK pathway;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;ESR-mediated signaling	PE1	19
+NX_P53350	Serine/threonine-protein kinase PLK1	603	68255	9.09	0	Midbody;Centrosome;Nucleus;Spindle;Kinetochore	NA	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710).	Catalytic activity is enhanced by phosphorylation of Thr-210. Phosphorylation at Thr-210 is first detected on centrosomes in the G2 phase of the cell cycle, peaks in prometaphase and gradually disappears from centrosomes during anaphase. Dephosphorylation at Thr-210 at centrosomes is probably mediated by protein phosphatase 1C (PP1C), via interaction with PPP1R12A/MYPT1. Autophosphorylation and phosphorylation of Ser-137 may not be significant for the activation of PLK1 during mitosis, but may enhance catalytic activity during recovery after DNA damage checkpoint. Phosphorylated in vitro by STK10.;Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) in anaphase and following DNA damage, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Ubiquitination and subsequent degradation prevents entry into mitosis and is essential to maintain an efficient G2 DNA damage checkpoint. Monoubiquitination at Lys-492 by the BCR(KLHL22) ubiquitin ligase complex does not lead to degradation: it promotes PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.;PLK1 is phosphorylated by STK10 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.	Cell cycle;Oocyte meiosis;Progesterone-mediated oocyte maturation;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Separation of Sister Chromatids;Activation of NIMA Kinases NEK9, NEK6, NEK7;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Condensation of Prophase Chromosomes;Polo-like kinase mediated events;Cyclin A/B1/B2 associated events during G2/M transition;Phosphorylation of the APC/C;Phosphorylation of Emi1;Recruitment of NuMA to mitotic centrosomes;Mitotic Metaphase/Anaphase Transition;Golgi Cisternae Pericentriolar Stack Reorganization;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Mitotic Telophase/Cytokinesis;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2	PE1	16
+NX_P53355	Death-associated protein kinase 1	1430	160046	6.37	0	Cytoplasm;Centrosome;Cytoskeleton	NA	Cannot induce apoptosis but can induce membrane blebbing.;Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.	Removal of the C-terminal tail of isoform 2 (corresponding to amino acids 296-337 of isoform 2) by proteolytic cleavage stimulates maximally its membrane-blebbing function.;Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex, leading to its degradation by the proteasome.;In response to mitogenic stimulation (PMA or EGF), phosphorylated at Ser-289; phosphorylation suppresses DAPK1 pro-apoptotic function. Autophosphorylation at Ser-308 inhibits its catalytic activity. Phosphorylation at Ser-734 by MAPK1 increases its catalytic activity and promotes cytoplasmic retention of MAPK1. Endoplasmic-stress can cause dephosphorylation at Ser-308.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.	Pathways in cancer;Bladder cancer;Caspase activation via Dependence Receptors in the absence of ligand	PE1	9
+NX_P53365	Arfaptin-2	341	37856	5.72	0	Golgi apparatus;Nucleoplasm;trans-Golgi network membrane;Nucleolus	NA	Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site (PubMed:31204568). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658).	NA	NA	Retrograde transport at the Trans-Golgi-Network	PE1	11
+NX_P53367	Arfaptin-1	373	41738	6.24	0	Golgi apparatus;Nucleoplasm;trans-Golgi network membrane;Cytoplasmic vesicle	NA	Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.	Phosphorylated by PRKD1; phosphorylation delocalizes ARFIP1 from the Golgi and disrupts its ability to inhibit the activity of ADP-ribosylation factor, an important component of the vesicle scission machinery.	NA	NA	PE1	4
+NX_P53370	Nucleoside diphosphate-linked moiety X motif 6	316	35679	8.15	0	Cytoplasm;Mitochondrion;Nucleus	NA	May contribute to the regulation of cell proliferation.	NA	Belongs to the Nudix hydrolase family.	NA	PE1	4
+NX_P53384	Cytosolic Fe-S cluster assembly factor NUBP1	320	34534	5.15	0	Cytoplasm;Microtubule organizing center;Centriole;Cell projection;Cilium basal body;Centrosome;Cilium axoneme;Cytosol;Nucleus	NA	Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity).	NA	Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.	Cytosolic iron-sulfur cluster assembly	PE1	16
+NX_P53396	ATP-citrate synthase	1101	120839	6.95	0	Nucleoplasm;Cytosol;Cell membrane	NA	Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.	Phosphorylated by PKA and GSK3 in a sequential manner; phosphorylation results in activation of its activity (PubMed:10653665). Phosphorylation on Thr-447 and Ser-451 depends on the phosphorylation state of Ser-455 (By similarity). Phosphorylation on Ser-455 is decreased by prior phosphorylation on the other 2 residues (By similarity).;ISGylated.;Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF (PubMed:23932781). Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites (PubMed:23932781). Acetylation promotes de novo lipid synthesis (PubMed:23932781). Deacetylated by SIRT2.;Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).	In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.;In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	Citrate cycle (TCA cycle);Metabolic pathways;ChREBP activates metabolic gene expression;Fatty acyl-CoA biosynthesis;Neutrophil degranulation	PE1	17
+NX_P53420	Collagen alpha-4(IV) chain	1690	164038	8.9	0	Basement membrane	Alport syndrome 2, autosomal recessive;Hematuria, benign familial	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.	Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.;Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.;The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.	Belongs to the type IV collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Pathways in cancer;Small cell lung cancer;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Non-integrin membrane-ECM interactions;Laminin interactions;Crosslinking of collagen fibrils;Anchoring fibril formation;Extracellular matrix organization;Collagen chain trimerization	PE1	2
+NX_P53539	Protein fosB	338	35928	4.78	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	FosB interacts with Jun proteins enhancing their DNA binding activity.	NA	Belongs to the bZIP family. Fos subfamily.	Osteoclast differentiation;Estrogen-dependent gene expression	PE1	19
+NX_P53567	CCAAT/enhancer-binding protein gamma	150	16408	9.77	0	Nucleoplasm;Nucleus	NA	Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.	NA	Belongs to the bZIP family. C/EBP subfamily.	Tuberculosis;ATF4 activates genes in response to endoplasmic reticulum stress	PE1	19
+NX_P53582	Methionine aminopeptidase 1	386	43215	6.75	0	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	NA	Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.	NA	Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	Inactivation, recovery and regulation of the phototransduction cascade	PE1	4
+NX_P53597	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	346	36250	9.01	0	Mitochondrion;Cell membrane	Mitochondrial DNA depletion syndrome 9	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	NA	Belongs to the succinate/malate CoA ligase alpha subunit family.	Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.;Citrate cycle (TCA cycle);Propanoate metabolism;Metabolic pathways;Citric acid cycle (TCA cycle)	PE1	2
+NX_P53602	Diphosphomevalonate decarboxylase	400	43405	6.8	0	Cytosol;Cell junction	Porokeratosis 7, multiple types	Performs the first committed step in the biosynthesis of isoprenes.	NA	Belongs to the diphosphomevalonate decarboxylase family.	Steroid biosynthesis; cholesterol biosynthesis.;Terpenoid backbone biosynthesis;Metabolic pathways;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP);Synthesis of Dolichyl-phosphate	PE1	16
+NX_P53609	Geranylgeranyl transferase type-1 subunit beta	377	42368	6.37	0	Endoplasmic reticulum;Nucleoplasm;Cytosol	NA	Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.	NA	Belongs to the protein prenyltransferase subunit beta family.	NA	PE1	5
+NX_P53611	Geranylgeranyl transferase type-2 subunit beta	331	36924	4.89	0	Cytoplasmic vesicle	NA	Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.	NA	Belongs to the protein prenyltransferase subunit beta family.	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;RAB geranylgeranylation	PE1	1
+NX_P53618	Coatomer subunit beta	953	107142	5.72	0	Golgi apparatus;Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Cell membrane;COPI-coated vesicle membrane;Golgi apparatus membrane;Cytoplasmic vesicle;Cytosol	NA	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments.	Proteolytically cleaved between Ser-528 and Ser-529 by CAPN8.	NA	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Neutrophil degranulation	PE1	11
+NX_P53621	Coatomer subunit alpha	1224	138346	7.7	0	Golgi apparatus;Cytoplasm;Secreted;COPI-coated vesicle membrane;Nucleoplasm;Golgi apparatus membrane;Cytosol	Autoimmune interstitial lung, joint, and kidney disease	Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.;The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).	NA	NA	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	1
+NX_P53634	Dipeptidyl peptidase 1	463	51854	6.53	0	Endoplasmic reticulum;Lysosome;Cytoplasmic vesicle	Haim-Munk syndrome;Papillon-Lefevre syndrome;Periodontititis, aggressive, 1	Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.	N-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes.;In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond.	Belongs to the peptidase C1 family.	Lysosome;MHC class II antigen presentation;COPII-mediated vesicle transport;Cargo concentration in the ER;Neutrophil degranulation	PE1	11
+NX_P53667	LIM domain kinase 1	647	72585	6.53	0	Cytoplasm;Nucleus speckle;Lamellipodium;Cytosol;Nucleus	NA	Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).;Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development.	Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF6 leads to proteasomal degradation through the 26S proteasome, modulating LIMK1 levels in the growth cone and its effect on axonal outgrowth. Also polyubiquitinated by RLIM (By similarity).;Autophosphorylated (By similarity). Phosphorylated on Thr-508 by ROCK1 and PAK1, resulting in activation. Phosphorylated by PAK4 which increases the ability of LIMK1 to phosphorylate cofilin. Phosphorylated at Ser-323 by MAPKAPK2 during activation of VEGFA-induced signaling, which results in activation of LIMK1 and promotion of actin reorganization, cell migration, and tubule formation of endothelial cells. Dephosphorylated and inactivated by SSH1. Phosphorylated by CDC42BP.;LIMK1 is phosphorylated by CDC42BPA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);LIMK1 is phosphorylated by PAK4 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	Axon guidance;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Sema3A PAK dependent Axon repulsion;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs	PE1	7
+NX_P53671	LIM domain kinase 2	638	72232	6.83	0	Cytoplasm;Nucleoplasm;Endoplasmic reticulum;Cytosol;Nucleus	NA	Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.	Phosphorylated on serine and/or threonine residues by ROCK1.	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	Axon guidance;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;EPHB-mediated forward signaling;Sema4D induced cell migration and growth-cone collapse;RHO GTPases Activate ROCKs	PE1	22
+NX_P53672	Beta-crystallin A2	197	22096	5.94	0	NA	Cataract 42	Crystallins are the dominant structural components of the vertebrate eye lens.	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	2
+NX_P53673	Beta-crystallin A4	196	22374	5.83	0	NA	Cataract 23, multiple types	Crystallins are the dominant structural components of the vertebrate eye lens.	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	22
+NX_P53674	Beta-crystallin B1	252	28023	8.59	0	NA	Cataract 17, multiple types	Crystallins are the dominant structural components of the vertebrate eye lens.	Specific cleavages in the N-terminal arm occur during lens maturation and give rise to truncated forms, leading to impaired oligomerization and protein insolubilization.	Belongs to the beta/gamma-crystallin family.	NA	PE1	22
+NX_P53675	Clathrin heavy chain 2	1640	187030	5.57	0	Coated pit;Cytoplasmic vesicle membrane;Cytoplasmic vesicle	NA	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity).	NA	Belongs to the clathrin heavy chain family.	Lysosome;Endocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Huntington's disease;Bacterial invasion of epithelial cells;EPH-ephrin mediated repulsion of cells;Gap junction degradation;Formation of annular gap junctions;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	22
+NX_P53677	AP-3 complex subunit mu-2	418	46977	7.15	0	Golgi apparatus;Cytoplasmic vesicle membrane	NA	Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.	NA	Belongs to the adaptor complexes medium subunit family.	Lysosome	PE1	8
+NX_P53680	AP-2 complex subunit sigma	142	17018	5.82	0	Coated pit;Cell membrane	Hypocalciuric hypercalcemia, familial 3	Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis.	NA	Belongs to the adaptor complexes small subunit family.	Endocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Huntington's disease;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Retrograde neurotrophin signalling;Recycling pathway of L1;Nef Mediated CD8 Down-regulation;WNT5A-dependent internalization of FZD4;Nef Mediated CD4 Down-regulation;Trafficking of GluR2-containing AMPA receptors;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance	PE1	19
+NX_P53701	Cytochrome c-type heme lyase	268	30602	6.25	0	Membrane;Mitochondrion inner membrane;Mitochondrion	Linear skin defects with multiple congenital anomalies 1	Links covalently the heme group to the apoprotein of cytochrome c.	NA	Belongs to the cytochrome c-type heme lyase family.	Porphyrin and chlorophyll metabolism	PE1	X
+NX_P53708	Integrin alpha-8	1063	117474	5.37	1	Membrane;Cell membrane	Renal hypodysplasia/aplasia 1	Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.	NA	Belongs to the integrin alpha chain family.	Focal adhesion;ECM-receptor interaction;Cell adhesion molecules (CAMs);Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Integrin cell surface interactions;ECM proteoglycans;Molecules associated with elastic fibres	PE1	10
+NX_P53778	Mitogen-activated protein kinase 12	367	41940	5.98	0	Cytoplasm;Nucleus speckle;Mitochondrion;Cytosol;Nucleus	NA	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.	Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway.;Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K3/MKK3 and MAP2K6/MKK6, which activates the enzyme.;MAPK12 is phosphorylated by MAP2K7	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK signaling pathway;Oocyte meiosis;VEGF signaling pathway;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Dopaminergic synapse;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Amyotrophic lateral sclerosis (ALS);Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Salmonella infection;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Hepatitis C;Influenza A;DSCAM interactions;NOD1/2 Signaling Pathway;VEGFA-VEGFR2 Pathway;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;p38MAPK events;Myogenesis	PE1	22
+NX_P53779	Mitogen-activated protein kinase 10	464	52585	6.33	0	Membrane;Cytoplasm;Mitochondrion;Nucleus	NA	Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).	Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro.;Palmitoylation regulates subcellular location and axonal development.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK signaling pathway;ErbB signaling pathway;Protein processing in endoplasmic reticulum;Wnt signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Fc epsilon RI signaling pathway;Neurotrophin signaling pathway;Dopaminergic synapse;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Adipocytokine signaling pathway;Type II diabetes mellitus;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Salmonella infection;Pertussis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Hepatitis C;Influenza A;HTLV-I infection;Herpes simplex infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors	PE1	4
+NX_P53794	Sodium/myo-inositol cotransporter	718	79694	7.01	12	Membrane;Cytosol;Cell membrane	NA	Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.	NA	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Inositol transporters	PE1	21
+NX_P53801	Pituitary tumor-transforming gene 1 protein-interacting protein	180	20324	9.14	1	Golgi apparatus;Cytoplasm;Cell membrane;Nucleus membrane;Membrane;Nucleoplasm;Nucleus	NA	May facilitate PTTG1 nuclear translocation.	NA	NA	NA	PE1	21
+NX_P53803	DNA-directed RNA polymerases I, II, and III subunit RPABC4	58	7004	9.27	0	Nucleoplasm;Nucleus;Nucleolus;Cytoskeleton	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.	NA	Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Huntington's disease;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Cytosolic sensors of pathogen-associated DNA;MicroRNA (miRNA) biogenesis;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	8
+NX_P53804	E3 ubiquitin-protein ligase TTC3	2025	229869	7.53	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.	Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.	NA	Protein modification; protein ubiquitination.	PE1	21
+NX_P53805	Calcipressin-1	252	28079	5.09	0	Cytosol	NA	Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity).	Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.	Belongs to the RCAN family.	NA	PE1	21
+NX_P53814	Smoothelin	917	99059	9.2	0	Nucleoplasm;Cytoskeleton	NA	Structural protein of the cytoskeleton.	NA	Belongs to the smoothelin family.	NA	PE1	22
+NX_P53816	Phospholipase A and acyltransferase 3	162	17937	7.76	1	Peroxisome membrane;Cytoplasm;Perinuclear region;Cell membrane	NA	Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852).;(Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PubMed:28077878). May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection (PubMed:28077878). Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome (PubMed:28077878). May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery (PubMed:28077878). The lipid-modifying enzyme activity is required for this process (PubMed:28077878).	NA	Belongs to the H-rev107 family.	Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI	PE1	11
+NX_P53985	Monocarboxylate transporter 1	500	53944	8.91	12	Cell junction;Cell membrane	Symptomatic deficiency in lactate transport;Monocarboxylate transporter 1 deficiency;Familial hyperinsulinemic hypoglycemia 7	Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	Pyruvate metabolism;Basigin interactions;Proton-coupled monocarboxylate transport;Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	PE1	1
+NX_P53990	IST1 homolog	364	39751	5.22	0	Cytoplasmic vesicle;Centrosome;Nucleus envelope;Midbody	NA	ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).	NA	Belongs to the IST1 family.	Neutrophil degranulation	PE1	16
+NX_P53992	Protein transport protein Sec24C	1094	118325	6.71	0	Golgi apparatus;Cytoplasm;Endoplasmic reticulum membrane;COPII-coated vesicle membrane;Cytoplasmic vesicle;Cytosol	NA	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).	NA	Belongs to the SEC23/SEC24 family. SEC24 subfamily.	Protein processing in endoplasmic reticulum;MHC class II antigen presentation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;Cargo concentration in the ER	PE1	10
+NX_P53999	Activated RNA polymerase II transcriptional coactivator p15	127	14395	9.6	0	Nucleoplasm;Nucleus;Nucleolus	NA	General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).	Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.	Belongs to the transcriptional coactivator PC4 family.	NA	PE1	5
+NX_P54098	DNA polymerase subunit gamma-1	1239	139562	6.46	0	Mitochondrion;Mitochondrion nucleoid	Sensory ataxic neuropathy dysarthria and ophthalmoparesis;Leigh syndrome;Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive, 1;Mitochondrial DNA depletion syndrome 4A;Mitochondrial DNA depletion syndrome 4B;Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 1;Spinocerebellar ataxia with epilepsy	Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.	NA	Belongs to the DNA polymerase type-A family.	Metabolic pathways	PE1	15
+NX_P54105	Methylosome subunit pICln	237	26215	3.97	0	Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.	NA	Belongs to the pICln (TC 1.A.47) family.	RNA transport;snRNP Assembly	PE1	11
+NX_P54107	Cysteine-rich secretory protein 1	249	28481	5.57	0	NA	NA	May have a role in sperm-egg fusion and maturation.	NA	Belongs to the CRISP family.	NA	PE1	6
+NX_P54108	Cysteine-rich secretory protein 3	245	27630	8.09	0	Secreted	NA	NA	NA	Belongs to the CRISP family.	Neutrophil degranulation	PE1	6
+NX_P54132	Bloom syndrome protein	1417	159000	7.33	0	Nucleoplasm;Cytosol;Nucleus	Bloom syndrome	ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9388193, PubMed:24816114, PubMed:25901030). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (PubMed:20639533, PubMed:24257077, PubMed:25901030).	Phosphorylated in response to DNA damage. Phosphorylation requires the FANCA-FANCC-FANCE-FANCF-FANCG protein complex, as well as the presence of RMI1.;BLM is phosphorylated by MAPK3;BLM is phosphorylated by CHEK1	Belongs to the helicase family. RecQ subfamily.	Homologous recombination;Fanconi anemia pathway;SUMOylation of DNA damage response and repair proteins;Meiotic recombination;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	15
+NX_P54136	Arginine--tRNA ligase, cytoplasmic	660	75379	6.26	0	Nucleoplasm;Cytoplasm;Cytosol	Leukodystrophy, hypomyelinating, 9	Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684).	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation;Selenoamino acid metabolism	PE1	5
+NX_P54198	Protein HIRA	1017	111835	8.4	0	Nucleoplasm;PML body;Nucleus	NA	Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.	Sumoylated.;Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo.	Belongs to the WD repeat HIR1 family.	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	PE1	22
+NX_P54219	Chromaffin granule amine transporter	525	56257	5.6	12	Cytoplasmic vesicle membrane;Synaptic vesicle membrane;Endoplasmic reticulum membrane	NA	Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.	NA	Belongs to the major facilitator superfamily. Vesicular transporter family.	Synaptic vesicle cycle;Dopaminergic synapse;Parkinson's disease;Na+/Cl- dependent neurotransmitter transporters	PE1	8
+NX_P54252	Ataxin-3	361	41250	4.69	0	Cell membrane;Nucleus matrix;Nucleolus;Nucleoplasm;Nucleus	Spinocerebellar ataxia 3	Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460).	Monoubiquitinated N-terminally by UBE2W, possibly leading to activate the deubiquitinating enzyme activity (PubMed:23696636).	NA	Protein processing in endoplasmic reticulum;Josephin domain DUBs;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	14
+NX_P54253	Ataxin-1	815	86923	8.49	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	Spinocerebellar ataxia 1	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity).	Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.;Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract.;Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of expanded poly-Gln repeats in spinocerebellar ataxia 1 (SCA1) patients impairs ubiquitination and degradation, leading to accumulation of ATXN1 in neurons and subsequent toxicity.	Belongs to the ATXN1 family.	NA	PE1	6
+NX_P54257	Huntingtin-associated protein 1	671	75506	4.68	0	Cytoplasm;Dendritic spine;Mitochondrion;Neuron projection;Early endosome;Growth cone;Nucleolus;Endoplasmic reticulum;Presynapse;Autophagosome;Lysosome;Cytosol;Axon;Dendrite;Synaptic vesicle;Nucleus;Cytoskeleton	NA	Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).	NA	NA	GABAergic synapse;Huntington's disease	PE1	17
+NX_P54259	Atrophin-1	1190	125414	9.01	0	Nucleoplasm;Cell junction;Perinuclear region;Nucleus	Dentatorubral-pallidoluysian atrophy	Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.	Phosphorylated in vitro by MAPK8/JNK1 on Ser-739. Mutant ATN1 sequences with expanded poly-Gln (polyQ) traits are more slowly phosphorylated.;Proteolytically cleaved, probably in the nucleus, to produce two C-terminal fragments of 140 kDa (F1) and 125 kDa (F2) each containing poly-Gln (polyQ) tracts. F2 is produced by cleavage by caspases and is exported into the cytoplasm. In vitro, cleavage increases with an increase in the number of polyQ tracts. C-terminal proteolytic products appear to be the cause of cell toxicity. In vitro cleavage at Asp-109.	NA	Regulation of PTEN gene transcription	PE1	12
+NX_P54274	Telomeric repeat-binding factor 1	439	50246	5.99	0	Nucleolus;Spindle;Telomere;Nucleus	NA	Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.	Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.;Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.;ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.	NA	Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine	PE1	8
+NX_P54277	PMS1 protein homolog 1	932	105830	6.23	0	Nucleoplasm;Nucleus	NA	Probably involved in the repair of mismatches in DNA.	NA	Belongs to the DNA mismatch repair MutL/HexB family.	NA	PE1	2
+NX_P54278	Mismatch repair endonuclease PMS2	862	95797	6.4	0	Nucleus	Hereditary non-polyposis colorectal cancer 4;Mismatch repair cancer syndrome	Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages.	NA	Belongs to the DNA mismatch repair MutL/HexB family.	Mismatch repair;Fanconi anemia pathway;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);TP53 Regulates Transcription of DNA Repair Genes;Defective Mismatch Repair Associated With MLH1;Defective Mismatch Repair Associated With PMS2	PE1	7
+NX_P54284	Voltage-dependent L-type calcium channel subunit beta-3	484	54532	5.93	0	Golgi apparatus;Cytoplasm;Cytoplasmic vesicle	NA	Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).	CACNB3 is phosphorylated by CAMK2D (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the calcium channel beta subunit family.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;NCAM1 interactions;Adrenaline,noradrenaline inhibits insulin secretion;Presynaptic depolarization and calcium channel opening;Regulation of insulin secretion;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	12
+NX_P54289	Voltage-dependent calcium channel subunit alpha-2/delta-1	1103	124568	5.12	1	Membrane;Cytoplasm	NA	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).	Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.	Belongs to the calcium channel subunit alpha-2/delta family.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	7
+NX_P54296	Myomesin-2	1465	164896	5.82	0	Mitochondrion;M line	NA	Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.	NA	NA	NA	PE1	8
+NX_P54315	Inactive pancreatic lipase-related protein 1	467	51848	5.47	0	Secreted	NA	May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Glycerolipid metabolism;Metabolic pathways;Pancreatic secretion;Fat digestion and absorption;Digestion of dietary lipid	PE1	10
+NX_P54317	Pancreatic lipase-related protein 2	469	51961	5.27	0	Secreted	NA	Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Glycerolipid metabolism;Metabolic pathways;Pancreatic secretion;Fat digestion and absorption;Digestion of dietary lipid	PE1	10
+NX_P54368	Ornithine decarboxylase antizyme 1	228	25406	7.12	0	Cytoplasmic vesicle;Centriolar satellite	NA	Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147).	NA	Belongs to the ODC antizyme family.	Regulation of ornithine decarboxylase (ODC)	PE1	19
+NX_P54577	Tyrosine--tRNA ligase, cytoplasmic	528	59143	6.61	0	Cytoplasm;Cytosol	Charcot-Marie-Tooth disease, dominant, intermediate type, C	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation	PE1	1
+NX_P54578	Ubiquitin carboxyl-terminal hydrolase 14	494	56069	5.2	0	Cytoplasm;Cytosol;Cell membrane	NA	Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation.	NA	Belongs to the peptidase C19 family. USP14/UBP6 subfamily.	Ub-specific processing proteases	PE1	18
+NX_P54619	5'-AMP-activated protein kinase subunit gamma-1	331	37579	6.42	0	Nucleoplasm;Cytosol	NA	AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.	Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.;PRKAG1 is phosphorylated by ULK2	Belongs to the 5'-AMP-activated protein kinase gamma subunit family.	Insulin signaling pathway;Adipocytokine signaling pathway;Hypertrophic cardiomyopathy (HCM);Macroautophagy;Translocation of SLC2A4 (GLUT4) to the plasma membrane;TP53 Regulates Metabolic Genes;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Energy dependent regulation of mTOR by LKB1-AMPK;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs;Lipophagy	PE1	12
+NX_P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2	552	62320	7.65	0	Golgi apparatus;Cytoplasm;Nucleus speckle;Nucleus	NA	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. In that process also activates WDR45 (PubMed:28561066). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1. Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation. Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity).	Phosphorylated at Thr-172 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-172 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-172, but at much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. Dephosphorylated by PPM1A and PPM1B at Thr-172 (mediated by STK11/LKB1).;Ubiquitinated.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	Regulation of autophagy;mTOR signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Hypertrophic cardiomyopathy (HCM);Macroautophagy;Translocation of SLC2A4 (GLUT4) to the plasma membrane;TP53 Regulates Metabolic Genes;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Energy dependent regulation of mTOR by LKB1-AMPK;AMPK inhibits chREBP transcriptional activation activity;Import of palmitoyl-CoA into the mitochondrial matrix;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs;Lipophagy	PE1	1
+NX_P54652	Heat shock-related 70 kDa protein 2	639	70021	5.56	0	Spindle	NA	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).	NA	Belongs to the heat shock protein 70 family.	Spliceosome;MAPK signaling pathway;Protein processing in endoplasmic reticulum;Endocytosis;Antigen processing and presentation;Legionellosis;Toxoplasmosis;Measles;Influenza A;Regulation of HSF1-mediated heat shock response;Meiotic synapsis;Attenuation phase;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	14
+NX_P54687	Branched-chain-amino-acid aminotransferase, cytosolic	386	42966	5.17	0	Cytoplasm	NA	Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.	NA	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Valine, leucine and isoleucine degradation;Valine, leucine and isoleucine biosynthesis;Pantothenate and CoA biosynthesis;Metabolic pathways;Branched-chain amino acid catabolism	PE1	12
+NX_P54707	Potassium-transporting ATPase alpha chain 2	1039	115511	6.12	10	Membrane	NA	Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.	Oxidative phosphorylation;Ion transport by P-type ATPases	PE1	13
+NX_P54709	Sodium/potassium-transporting ATPase subunit beta-3	279	31513	8.58	1	Melanosome;Cell membrane	NA	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.	NA	Belongs to the X(+)/potassium ATPases subunit beta family.	Cardiac muscle contraction;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Protein digestion and absorption;Bile secretion;Mineral absorption;Ion transport by P-type ATPases;Basigin interactions;Ion homeostasis	PE1	3
+NX_P54710	Sodium/potassium-transporting ATPase subunit gamma	66	7283	7.88	1	Membrane;Mitochondrion	Hypomagnesemia 2	May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.	NA	Belongs to the FXYD family.	Cardiac muscle contraction;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Protein digestion and absorption;Bile secretion;Mineral absorption;Ion transport by P-type ATPases;Ion homeostasis	PE1	11
+NX_P54725	UV excision repair protein RAD23 homolog A	363	39609	4.56	0	Nucleoplasm;Cytosol;Nucleus	NA	Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.;Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.;(Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.	NA	Belongs to the RAD23 family.	Nucleotide excision repair;Protein processing in endoplasmic reticulum;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Josephin domain DUBs	PE1	19
+NX_P54727	UV excision repair protein RAD23 homolog B	409	43171	4.79	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.;Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.;The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.	NA	Belongs to the RAD23 family.	Nucleotide excision repair;Protein processing in endoplasmic reticulum;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Josephin domain DUBs	PE1	9
+NX_P54750	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	535	61252	5.72	0	Cytoplasm;Nucleoplasm	NA	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.	Purine metabolism;Calcium signaling pathway;Taste transduction;G alpha (s) signalling events;cGMP effects;Cam-PDE 1 activation	PE1	2
+NX_P54753	Ephrin type-B receptor 3	998	110330	5.95	1	Dendrite;Cell membrane	NA	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.	Phosphorylated. Autophosphorylates upon ligand-binding. Autophosphorylation on Tyr-614 is required for interaction with SH2 domain-containing proteins.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells	PE1	3
+NX_P54756	Ephrin type-A receptor 5	1037	114803	6.53	1	Endoplasmic reticulum;Axon;Dendrite;Cell membrane	NA	Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).	Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion (By similarity).;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	4
+NX_P54760	Ephrin type-B receptor 4	987	108270	6.48	1	Cell membrane	Lymphatic malformation 7;Capillary malformation-arteriovenous malformation 2	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.	Phosphorylated; autophosphorylation is stimulated by EFNB2.;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells	PE1	7
+NX_P54762	Ephrin type-B receptor 1	984	109885	6.03	1	Cell membrane;Endoplasmic reticulum;Early endosome membrane;Cytosol;Dendrite	NA	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity).	Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation.;Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL.;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells	PE1	3
+NX_P54764	Ephrin type-A receptor 4	986	109860	6.21	1	Cell membrane;Early endosome;Adherens junction;Postsynaptic density;Axon;Dendrite	NA	Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (By similarity).	NA	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	2
+NX_P54792	Putative segment polarity protein dishevelled homolog DVL1P1	670	73254	6.02	0	Cytoplasm	NA	May play a role in the signal transduction pathway mediated by multiple Wnt genes.	NA	Belongs to the DSH family.	NA	PE5	22
+NX_P54793	Arylsulfatase F	590	65940	6.78	0	Cytosol;Secreted	NA	NA	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Glycosphingolipid metabolism;The activation of arylsulfatases	PE1	X
+NX_P54802	Alpha-N-acetylglucosaminidase	743	82266	6.2	0	Lysosome	Charcot-Marie-Tooth disease 2V;Mucopolysaccharidosis 3B	Involved in the degradation of heparan sulfate.	NA	Belongs to the glycosyl hydrolase 89 family.	Glycosaminoglycan degradation;Metabolic pathways;Lysosome;HS-GAG degradation;MPS IIIB - Sanfilippo syndrome B	PE1	17
+NX_P54803	Galactocerebrosidase	685	77063	6.17	0	Lysosome	Leukodystrophy, globoid cell	Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.	NA	Belongs to the glycosyl hydrolase 59 family.	Sphingolipid metabolism;Metabolic pathways;Lysosome;Glycosphingolipid metabolism	PE1	14
+NX_P54819	Adenylate kinase 2, mitochondrial	239	26478	7.67	0	Mitochondrion intermembrane space	Reticular dysgenesis	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	NA	Belongs to the adenylate kinase family. AK2 subfamily.	Purine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	1
+NX_P54821	Paired mesoderm homeobox protein 1	245	27296	9.48	0	Nucleoplasm;Nucleus	Agnathia-otocephaly complex	Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity).	NA	Belongs to the paired homeobox family.	NA	PE1	1
+NX_P54826	Growth arrest-specific protein 1	345	35693	5.35	0	Nucleus speckle;Cell membrane	NA	Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.	NA	NA	Hedgehog signaling pathway;Activation of SMO;Ligand-receptor interactions	PE1	9
+NX_P54829	Tyrosine-protein phosphatase non-receptor type 5	565	63538	4.82	2	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.	Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase.;PTPN5 is phosphorylated by MAPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PTPN5 is phosphorylated by MAPK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.	MAPK signaling pathway;Interleukin-37 signaling	PE1	11
+NX_P54840	Glycogen [starch] synthase, liver	703	80989	6.35	0	NA	Glycogen storage disease 0	Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.	Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (By similarity). Phosphorylation at Ser-8 is not required for interaction with GYG1 (By similarity). Interaction with GYG1 does not regulate the phosphorylation at Ser-8 and Ser-641 (By similarity).	Belongs to the glycosyltransferase 3 family.	Glycan biosynthesis; glycogen biosynthesis.;Starch and sucrose metabolism;Insulin signaling pathway;Glycogen synthesis;Glycogen storage disease type 0 (liver GYS2);Glycogen storage disease type IV (GBE1)	PE1	12
+NX_P54845	Neural retina-specific leucine zipper protein	237	25940	7.73	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Retinal degeneration autosomal recessive clumped pigment type;Retinitis pigmentosa 27	Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001).	Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation (By similarity).;Phosphorylated (PubMed:11477108, PubMed:17335001).	Belongs to the bZIP family.	NA	PE1	14
+NX_P54849	Epithelial membrane protein 1	157	17563	8.18	4	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the PMP-22/EMP/MP20 family.	NA	PE1	12
+NX_P54851	Epithelial membrane protein 2	167	19199	7.55	4	Cytoplasm;Cell membrane;Nucleoplasm;Golgi apparatus membrane;Cytosol;Apical cell membrane;Membrane raft;Nucleus	Nephrotic syndrome 10	Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration and cell contraction through PTK2 and SRC activation (PubMed:21637765, PubMed:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199). Positively regulates cell proliferation (PubMed:24814193). Plays a role during cell death and cell blebbing (PubMed:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956). May play a role in glomerular filtration (By similarity).	NA	Belongs to the PMP-22/EMP/MP20 family.	NA	PE1	16
+NX_P54852	Epithelial membrane protein 3	163	18429	8.18	4	Cytoplasmic vesicle;Golgi apparatus;Membrane;Cell membrane	NA	Probably involved in cell proliferation and cell-cell interactions.	NA	Belongs to the PMP-22/EMP/MP20 family.	NA	PE1	19
+NX_P54855	UDP-glucuronosyltransferase 2B15	530	61036	8.98	1	Microsome membrane;Endoplasmic reticulum membrane	NA	UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	4
+NX_P54868	Hydroxymethylglutaryl-CoA synthase, mitochondrial	508	56635	8.4	0	Mitochondrion	3-hydroxy-3-methylglutaryl-CoA synthase-2 deficiency	This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Succinylated. Desuccinylated by SIRT5. Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity.	Belongs to the thiolase-like superfamily. HMG-CoA synthase family.	Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation;Butanoate metabolism;Terpenoid backbone biosynthesis;Metabolic pathways;PPAR signaling pathway;PPARA activates gene expression;Synthesis of Ketone Bodies	PE1	1
+NX_P54886	Delta-1-pyrroline-5-carboxylate synthase	795	87302	6.66	0	Mitochondrion inner membrane;Mitochondrion	Cutis laxa, autosomal dominant, 3;Spastic paraplegia 9A, autosomal dominant;Cutis laxa, autosomal recessive, 3A;Spastic paraplegia 9B, autosomal recessive	Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.	NA	In the N-terminal section; belongs to the glutamate 5-kinase family.;In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.;Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.;Arginine and proline metabolism;Metabolic pathways;Glutamate and glutamine metabolism	PE1	10
+NX_P54920	Alpha-soluble NSF attachment protein	295	33233	5.23	0	Cell membrane	NA	Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433).	NA	Belongs to the SNAP family.	Synaptic vesicle cycle;Golgi Associated Vesicle Biogenesis;COPII-mediated vesicle transport;Intra-Golgi traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network	PE1	19
+NX_P54922	[Protein ADP-ribosylarginine] hydrolase	357	39507	6.05	0	Nucleoplasm;Nucleus membrane	NA	Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.	NA	Belongs to the ADP-ribosylglycohydrolase family.	NA	PE1	3
+NX_P55000	Secreted Ly-6/uPAR-related protein 1	103	11186	5.21	0	Secreted	Mal de Meleda	Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have an immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).	NA	NA	NA	PE1	8
+NX_P55001	Microfibrillar-associated protein 2	183	20826	4.86	0	Extracellular matrix	NA	Component of the elastin-associated microfibrils.	O-glycosylated.;Forms intermolecular disulfide bonds either with other MAGP-1 molecules or with other components of the microfibrils. May form transglutaminase cross-links.	Belongs to the MFAP family.	Molecules associated with elastic fibres;Elastic fibre formation	PE1	1
+NX_P55008	Allograft inflammatory factor 1	147	16703	5.97	0	Ruffle membrane;Cytosol;Phagocytic cup;Cytoskeleton	NA	Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.	Phosphorylated on serine residues.	NA	NA	PE1	6
+NX_P55010	Eukaryotic translation initiation factor 5	431	49223	5.41	0	Cytosol;Cell membrane	NA	Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).	NA	Belongs to the eIF-2-beta/eIF-5 family.	RNA transport;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	14
+NX_P55011	Solute carrier family 12 member 2	1212	131447	5.98	12	Membrane;Cytoplasmic vesicle;Cell membrane	NA	Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.	NA	Belongs to the SLC12A transporter family.	Salivary secretion;Pancreatic secretion;Vibrio cholerae infection;Cation-coupled Chloride cotransporters	PE1	5
+NX_P55017	Solute carrier family 12 member 3	1021	113139	8.1	12	Cell membrane	Gitelman syndrome	Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:21613606, PubMed:22009145). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (By similarity).	Phosphorylated in response to IL18.;Ubiquitinated; ubiquitination is essential for regulation of endocytosis. The BCR(KLHL3) complex was initially identified as a candidate ubiquitin ligase for SLC12A3 (PubMed:22406640). However, it was later shown that it is not the case.	Belongs to the SLC12A transporter family.	Cation-coupled Chloride cotransporters;Defective SLC12A3 causes Gitelman syndrome (GS)	PE1	16
+NX_P55036	26S proteasome non-ATPase regulatory subunit 4	377	40737	4.68	0	NA	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.	NA	Belongs to the proteasome subunit S5A family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	1
+NX_P55039	Developmentally-regulated GTP-binding protein 2	364	40746	9.02	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation.	Hydroxylated (with S stereochemistry) at C-3 of Lys-21 by JMJD7; this modification hinders trypsin-catalyzed proteolysis in vitro.;Polyubiquitinated.	Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.	NA	PE1	17
+NX_P55040	GTP-binding protein GEM	296	33949	8.77	0	Cell membrane	NA	Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.	Phosphorylated on tyrosine residues.	Belongs to the small GTPase superfamily. RGK family.	NA	PE1	8
+NX_P55042	GTP-binding protein RAD	308	33245	9.06	0	Golgi apparatus;Nucleoplasm;Cell membrane	NA	May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.	NA	Belongs to the small GTPase superfamily. RGK family.	NA	PE1	16
+NX_P55055	Oxysterols receptor LXR-beta	460	50974	7.9	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).	Sumoylated by SUMO2 at Lys-409 and Lys-447 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.	Belongs to the nuclear hormone receptor family. NR1 subfamily.	PPARA activates gene expression;Nuclear Receptor transcription pathway;VLDLR internalisation and degradation;SUMOylation of intracellular receptors	PE1	19
+NX_P55056	Apolipoprotein C-IV	127	14553	9.19	0	Secreted	NA	May participate in lipoprotein metabolism.	NA	Belongs to the apolipoprotein C4 family.	VLDL assembly;VLDL clearance	PE1	19
+NX_P55058	Phospholipid transfer protein	493	54739	6.53	0	Secreted	NA	Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.	NA	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	PPAR signaling pathway;HDL remodeling	PE1	20
+NX_P55060	Exportin-2	971	110417	5.51	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.	NA	Belongs to the XPO2/CSE1 family.	NA	PE1	20
+NX_P55061	Bax inhibitor 1	237	26538	8.79	6	Endoplasmic reticulum membrane	NA	Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).	NA	Belongs to the BI1 family.	NA	PE1	12
+NX_P55064	Aquaporin-5	265	28292	8.82	6	Cytoplasmic vesicle membrane;Apical cell membrane;Cell membrane	Keratoderma, palmoplantar, Bothnian type	Forms a water-specific channel (PubMed:8621489, PubMed:18768791). Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity).	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family.	Salivary secretion;Passive transport by Aquaporins	PE1	12
+NX_P55072	Transitional endoplasmic reticulum ATPase	806	89322	5.14	0	Stress granule;Endoplasmic reticulum;Nucleoplasm;Cytosol;Nucleus	Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 1;Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia;Charcot-Marie-Tooth disease 2Y	Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Plays a role in the regulation of stress granules (SGs) clearance process upon arsenite-induced response (PubMed:29804830). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042607, PubMed:23042605). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with DDX58/RIG-I: interaction takes place when DDX58/RIG-I is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).	Methylation at Lys-315 catalyzed by VCPKMT is increased in the presence of ASPSCR1. Lys-315 methylation may decrease ATPase activity.;ISGylated.;Phosphorylated by tyrosine kinases in response to T-cell antigen receptor activation. Phosphorylated in mitotic cells.	Belongs to the AAA ATPase family.	Protein processing in endoplasmic reticulum;Legionellosis;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Translesion Synthesis by POLH;HSF1 activation;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Ovarian tumor domain proteases;Josephin domain DUBs;Neutrophil degranulation;E3 ubiquitin ligases ubiquitinate target proteins;Protein methylation	PE1	9
+NX_P55073	Thyroxine 5-deiodinase	304	33947	6.25	1	Endosome membrane;Cell membrane	NA	Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.	NA	Belongs to the iodothyronine deiodinase family.	Regulation of thyroid hormone activity	PE1	14
+NX_P55075	Fibroblast growth factor 8	233	26525	10.44	0	Secreted	Hypogonadotropic hypogonadism 6 with or without anosmia	Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111).	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR1;Signaling by activated point mutants of FGFR3;FGFR4 ligand binding and activation;FGFR3c ligand binding and activation;FGFR1c ligand binding and activation;FGFR2c ligand binding and activation;FGFR3 mutant receptor activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;Phospholipase C-mediated cascade, FGFR4;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;FGFR3b ligand binding and activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;FGFRL1 modulation of FGFR1 signaling;Signaling by FGFR3 point mutants in cancer	PE1	10
+NX_P55081	Microfibrillar-associated protein 1	439	51958	4.95	0	Nucleoplasm;Centrosome;Nucleus	NA	Involved in pre-mRNA splicing as a component of the spliceosome.	NA	Belongs to the MFAP1 family.	Molecules associated with elastic fibres	PE1	15
+NX_P55082	Microfibril-associated glycoprotein 3	362	40165	4.87	1	Golgi apparatus;Nucleoplasm;Cell membrane	NA	Component of the elastin-associated microfibrils.	Glycosylated.	NA	Molecules associated with elastic fibres	PE1	5
+NX_P55083	Microfibril-associated glycoprotein 4	255	28648	5.38	0	Endoplasmic reticulum;Extracellular matrix	NA	Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed:26601954).	NA	NA	Molecules associated with elastic fibres	PE1	17
+NX_P55084	Trifunctional enzyme subunit beta, mitochondrial	474	51294	9.45	0	Mitochondrion outer membrane;Endoplasmic reticulum;Mitochondrion inner membrane;Mitochondrion	Mitochondrial trifunctional protein deficiency	Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:8135828, PubMed:29915090, PubMed:30850536). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity (PubMed:8135828, PubMed:29915090, PubMed:30850536).	NA	Belongs to the thiolase-like superfamily. Thiolase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid elongation;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Metabolic pathways;mitochondrial fatty acid beta-oxidation of unsaturated fatty acids;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA;Beta oxidation of hexanoyl-CoA to butanoyl-CoA;Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA;Beta oxidation of palmitoyl-CoA to myristoyl-CoA;Acyl chain remodeling of CL;Beta oxidation of myristoyl-CoA to lauroyl-CoA	PE1	2
+NX_P55085	Proteinase-activated receptor 2	397	44126	9.66	7	Cell membrane	NA	Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.	Monoubiquitinated by CBL at the plasma membrane and in early endosomes; not required for receptor endocytosis but for translocation to late endosomes or lysosomes. Deubiquitination involves STAMBP and USP8; required for lysosomal trafficking and receptor degradation.;Multiple phosphorylated on serine and threonine residues in the cytoplasmic region upon receptor activation; required for receptor desensitization and recruitment of beta-arrestin.;N-glycosylated and sialylated.;A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand (PubMed:10831593, PubMed:19864598, PubMed:9020112, PubMed:10805786, PubMed:16478888). Activating serine proteases include trypsin, mast cell tryptase, coagulation factors VII and Xa, myeloblastin/PRTN3 and membrane-type serine protease 1/ST14 (PubMed:10831593, PubMed:19864598, PubMed:9020112, PubMed:10805786, PubMed:16478888, PubMed:23202369). Subsequent cleavage by serine proteases, including neutrophil elastase and cathepsin G, leads to receptor deactivation (PubMed:12594060). At least in part, implicated proteases are also shown to activate the receptor; the glycosylation status of the receptor is thought to contribute to the difference (PubMed:12171601). In addition to conventional trypsin-like proteases activated by other proteases and glycosidases derived from bacteria, fungi and insects (PubMed:11447194, PubMed:11441110, PubMed:17404307, PubMed:18474671, PubMed:19864598). Activated by serine protease allergens such as dust mite Der p3 and Der p9 and mold Pen c13 (PubMed:11441110, PubMed:17404307). Activated by P.gingivalis arginine-specific (trypsin-like) cysteine proteinases called gingipains (PubMed:11447194). Activated by S.griseus exogenous chitinase (PubMed:18474671). Activated by A.alternata aspartate protease; the cleavage generates non-conventional processed forms (PubMed:19864598).	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;African trypanosomiasis;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	5
+NX_P55087	Aquaporin-4	323	34830	7.59	6	Endosome membrane;Cell membrane;Basolateral cell membrane;Cell junction;Cell projection;Sarcolemma	NA	Forms a water-specific channel (PubMed:7559426, PubMed:8601457, PubMed:19383790). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity).	Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40% (By similarity).;Not palmitoylated.;Palmitoylated on its N-terminal region.	Belongs to the MIP/aquaporin (TC 1.A.8) family.	Vasopressin-regulated water reabsorption;Bile secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins	PE1	18
+NX_P55089	Urocortin	124	13458	11.7	0	Endoplasmic reticulum;Secreted	NA	Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).	NA	Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	Class B/2 (Secretin family receptors);Synthesis, secretion, and deacylation of Ghrelin	PE1	2
+NX_P55103	Inhibin beta C chain	352	38238	6.66	0	Secreted	NA	Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.	NA	Belongs to the TGF-beta family.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Glycoprotein hormones	PE1	12
+NX_P55107	Growth/differentiation factor 10	478	53122	9.58	0	Cytoplasmic vesicle;Secreted	NA	Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.	NA	Belongs to the TGF-beta family.	NA	PE1	10
+NX_P55145	Mesencephalic astrocyte-derived neurotrophic factor	182	20700	8.94	0	Endoplasmic reticulum;Endoplasmic reticulum lumen;Secreted;Sarcoplasmic reticulum lumen	NA	Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (PubMed:12794311). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (By similarity). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (PubMed:18561914, PubMed:22637475, PubMed:29497057). Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475). Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PubMed:29497057). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions (PubMed:29497057).	May contain sialic acid residues.	Belongs to the ARMET family.	Platelet degranulation	PE1	3
+NX_P55157	Microsomal triglyceride transfer protein large subunit	894	99351	8.61	0	Endoplasmic reticulum;Cytosol	Abetalipoproteinemia	Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785).	NA	NA	VLDL assembly;Chylomicron assembly	PE1	4
+NX_P55160	Nck-associated protein 1-like	1127	128153	6.39	1	Cytoplasm;Cytosol;Cell membrane	NA	Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648).	NA	Belongs to the HEM-1/HEM-2 family.	Regulation of actin cytoskeleton;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;VEGFA-VEGFR2 Pathway;Neutrophil degranulation	PE1	12
+NX_P55196	Afadin	1824	206804	6.06	0	Cytoplasm;Cell membrane;Cell junction;Adherens junction;Nucleoplasm	NA	Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011).	AFDN is phosphorylated by MAPK3	NA	Adherens junction;Tight junction;Leukocyte transendothelial migration;Adherens junctions interactions	PE1	6
+NX_P55197	Protein AF-10	1068	113320	8.49	0	Nucleoplasm;Nucleus	NA	Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).	NA	NA	NA	PE1	10
+NX_P55198	Protein AF-17	1093	112048	8.93	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	17
+NX_P55199	RNA polymerase II elongation factor ELL	621	68265	9.43	0	Cajal body;Nucleus speckle;Nucleus	NA	Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.	NA	Belongs to the ELL/occludin family.	Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;Transcription-Coupled Nucleotide Excision Repair (TC-NER);RNA polymerase II transcribes snRNA genes;TP53 Regulates Transcription of DNA Repair Genes	PE1	19
+NX_P55201	Peregrin	1214	137499	8.16	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	Intellectual developmental disorder with dysmorphic facies and ptosis	Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:27939640). Preferentially mediates histone H3-K23 acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358).	Acetylated by KAT6A.	NA	HATs acetylate histones;Regulation of TP53 Activity through Acetylation	PE1	3
+NX_P55209	Nucleosome assembly protein 1-like 1	391	45374	4.36	0	Cytoplasm;Melanosome;Nucleus;Cytoskeleton	NA	Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity).	Monoglycylated on glutamate residues. Cannot be polyglycylated due to the absence of functional TTLL10 in human (By similarity).;Polyglutamylated by TTLL4 on glutamate residues, resulting in polyglutamate chains on the gamma-carboxyl group. Both polyglutamylation and monoglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	12
+NX_P55210	Caspase-7	303	34277	5.72	0	Cytoplasm	NA	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.	Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.	Belongs to the peptidase C14A family.	Apoptosis;Alzheimer's disease;Pertussis;Legionellosis;Caspase-mediated cleavage of cytoskeletal proteins;Apoptotic cleavage of cellular proteins;Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes;SMAC, XIAP-regulated apoptotic response	PE1	10
+NX_P55211	Caspase-9	416	46281	5.73	0	Mitochondrion	NA	Lacks activity is an dominant-negative inhibitor of caspase-9.;Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).	Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.;Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl; occurs in the response of cells to DNA damage.	Belongs to the peptidase C14A family.	p53 signaling pathway;Apoptosis;VEGF signaling pathway;Alzheimer's disease;Parkinson's disease;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Legionellosis;Toxoplasmosis;Tuberculosis;Influenza A;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Endometrial cancer;Prostate cancer;Small cell lung cancer;Non-small cell lung cancer;Viral myocarditis;NOD1/2 Signaling Pathway;Caspase activation via Dependence Receptors in the absence of ligand;Constitutive Signaling by AKT1 E17K in Cancer;AKT phosphorylates targets in the cytosol;Formation of apoptosome;Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes;Regulation of the apoptosome activity	PE1	1
+NX_P55212	Caspase-6	293	33310	6.46	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.	Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.	Belongs to the peptidase C14A family.	Apoptosis;Caspase-mediated cleavage of cytoskeletal proteins;Apoptotic cleavage of cellular proteins;Breakdown of the nuclear lamina;TP53 Regulates Transcription of Caspase Activators and Caspases	PE1	4
+NX_P55259	Pancreatic secretory granule membrane major glycoprotein GP2	537	59480	5.08	0	Secreted;Cell membrane	NA	NA	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	16
+NX_P55263	Adenosine kinase	362	40545	6.24	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Hypermethioninemia due to adenosine kinase deficiency	ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.	NA	Belongs to the carbohydrate kinase PfkB family.	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.;Purine metabolism;Metabolic pathways;Purine salvage	PE1	10
+NX_P55265	Double-stranded RNA-specific adenosine deaminase	1226	136066	8.86	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	Dyschromatosis symmetrica hereditaria;Aicardi-Goutieres syndrome 6	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:7972084, PubMed:7565688, PubMed:12618436). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication.	Sumoylation reduces RNA-editing activity.	NA	Cytosolic DNA-sensing pathway;Measles;Influenza A;Interferon alpha/beta signaling;C6 deamination of adenosine;Formation of editosomes by ADAR proteins	PE1	1
+NX_P55268	Laminin subunit beta-2	1798	195981	6.07	0	Cytoplasmic vesicle;Basement membrane;Cytosol	Nephrotic syndrome 5 with or without ocular abnormalities;Pierson syndrome	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	NA	NA	Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Non-integrin membrane-ECM interactions;Laminin interactions;MET activates PTK2 signaling;Post-translational protein phosphorylation	PE1	3
+NX_P55273	Cyclin-dependent kinase 4 inhibitor D	166	17700	5.69	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Interacts strongly with CDK4 and CDK6 and inhibits them.	NA	Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.	Cell cycle;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Cyclin D associated events in G1	PE1	19
+NX_P55283	Cadherin-4	916	100281	4.65	1	Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.	NA	NA	Cell adhesion molecules (CAMs);Adherens junctions interactions;Myogenesis	PE1	20
+NX_P55285	Cadherin-6	790	88309	4.77	1	Cell junction;Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	Adherens junctions interactions	PE1	5
+NX_P55286	Cadherin-8	799	88253	4.55	1	Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	Adherens junctions interactions	PE1	16
+NX_P55287	Cadherin-11	796	87965	4.75	1	Cell membrane	Elsahy-Waters syndrome	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	Adherens junctions interactions	PE1	16
+NX_P55289	Cadherin-12	794	88332	4.64	1	Cytoplasmic vesicle;Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	Adherens junctions interactions	PE1	5
+NX_P55290	Cadherin-13	713	78287	4.8	0	Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.	NA	NA	Adherens junctions interactions	PE1	16
+NX_P55291	Cadherin-15	814	88916	4.81	1	Golgi apparatus;Cell membrane	Mental retardation, autosomal dominant 3	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.	NA	NA	Cell adhesion molecules (CAMs);Adherens junctions interactions;Myogenesis	PE1	16
+NX_P55316	Forkhead box protein G1	489	52352	8.99	0	Nucleus	Rett syndrome congenital variant	Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.	NA	NA	Regulation of MECP2 expression and activity;FOXO-mediated transcription of cell cycle genes	PE1	14
+NX_P55317	Hepatocyte nuclear factor 3-alpha	472	49148	8.93	0	Nucleoplasm;Nucleus;Nucleolus	NA	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.	NA	NA	Estrogen-dependent gene expression	PE1	14
+NX_P55318	Hepatocyte nuclear factor 3-gamma	350	37140	7.01	0	Nucleoplasm;Nucleus	NA	Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.	NA	NA	Maturity onset diabetes of the young;Regulation of gene expression in beta cells	PE1	19
+NX_P55327	Tumor protein D52	224	24327	4.79	0	Golgi apparatus;Cytosol	NA	NA	NA	Belongs to the TPD52 family.	Golgi Associated Vesicle Biogenesis	PE1	8
+NX_P55344	Lens fiber membrane intrinsic protein	173	19674	9.64	4	Membrane	Cataract, multiple types 19	Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.	NA	Belongs to the PMP-22/EMP/MP20 family.	NA	PE1	19
+NX_P55345	Protein arginine N-methyltransferase 2	433	49042	5.03	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	NA	PE1	21
+NX_P55347	Homeobox protein PKNOX1	436	47607	4.79	0	Nucleoplasm;Nucleus	NA	Activates transcription in the presence of PBX1A and HOXA1.	NA	Belongs to the TALE/MEIS homeobox family.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	21
+NX_P55735	Protein SEC13 homolog	322	35541	5.22	0	Cytoplasm;Endoplasmic reticulum membrane;Nuclear pore complex;Lysosome membrane;Endoplasmic reticulum;COPII-coated vesicle membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity).;As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).	NA	Belongs to the WD repeat SEC13 family.	RNA transport;Protein processing in endoplasmic reticulum;Separation of Sister Chromatids;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;MHC class II antigen presentation;snRNP Assembly;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;COPII-mediated vesicle transport;NEP/NS2 Interacts with the Cellular Export Machinery;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	3
+NX_P55769	NHP2-like protein 1	128	14174	8.72	0	Nucleus;Nucleolus	NA	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:17412961).	NA	Belongs to the eukaryotic ribosomal protein eL8 family.	Ribosome biogenesis in eukaryotes;Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	22
+NX_P55771	Paired box protein Pax-9	341	36310	9.39	0	Nucleoplasm;Mitochondrion;Nucleus	Tooth agenesis, selective, 3	Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.	NA	NA	NA	PE1	14
+NX_P55773	C-C motif chemokine 23	120	13411	9.21	0	Secreted	NA	Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;G alpha (q) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands	PE1	17
+NX_P55774	C-C motif chemokine 18	89	9849	9.06	0	Secreted	NA	Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.	The Cys-30/Cys-54 disulfide bond is required for activity.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway	PE1	17
+NX_P55786	Puromycin-sensitive aminopeptidase	919	103276	5.49	0	Cytoplasm;Cytosol;Nucleus	NA	Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.	NA	Belongs to the peptidase M1 family.	Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	17
+NX_P55789	FAD-linked sulfhydryl oxidase ALR	205	23449	7.57	0	Cytoplasm;Mitochondrion;Mitochondrion intermembrane space;Secreted;Cytosol	Myopathy, mitochondrial progressive, with congenital cataract, hearing loss and developmental delay	May act as an autocrine hepatotrophic growth factor promoting liver regeneration.;FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.	NA	NA	Mitochondrial protein import	PE1	16
+NX_P55795	Heterogeneous nuclear ribonucleoprotein H2	449	49264	5.89	0	Nucleoplasm	Mental retardation, X-linked, syndromic, Bain type	This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).	NA	NA	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA	PE1	X
+NX_P55808	Glycoprotein Xg	180	19723	6.95	1	Cell membrane	NA	NA	O-glycosylated.	Belongs to the CD99 family.	NA	PE1	X
+NX_P55809	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	520	56158	7.13	0	Mitochondrion matrix;Mitochondrion	Succinyl-CoA:3-oxoacid CoA transferase deficiency	Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	NA	Belongs to the 3-oxoacid CoA-transferase family.	Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation;Butanoate metabolism;Utilization of Ketone Bodies	PE1	5
+NX_P55822	SH3 domain-binding glutamic acid-rich protein	239	26086	4.09	0	Cytosol;Cell membrane	NA	NA	NA	Belongs to the SH3BGR family.	NA	PE1	21
+NX_P55851	Mitochondrial uncoupling protein 2	309	33229	9.74	6	Mitochondrion inner membrane;Mitochondrion	NA	UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	The fatty acid cycling model;The proton buffering model	PE1	11
+NX_P55854	Small ubiquitin-related modifier 3	103	11637	5.32	0	Cytoplasm;PML body;Nucleus	NA	Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).	Polymeric chains can be formed through Lys-11 cross-linking.;Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.	Belongs to the ubiquitin family. SUMO subfamily.	RNA transport;SUMOylation of DNA damage response and repair proteins;SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;Formation of Incision Complex in GG-NER;SUMOylation of DNA replication proteins;SUMOylation of transcription factors;SUMOylation of chromatin organization proteins;SUMOylation of intracellular receptors;SUMOylation of transcription cofactors;SUMOylation of immune response proteins	PE1	21
+NX_P55884	Eukaryotic translation initiation factor 3 subunit B	814	92482	4.89	0	Nucleoplasm;Cytoplasm;Cytosol	NA	RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).;(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).	Phosphorylated. Phosphorylation is enhanced upon serum stimulation.	Belongs to the eIF-3 subunit B family.	RNA transport;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	7
+NX_P55895	V(D)J recombination-activating protein 2	527	59241	5.56	0	Nucleoplasm;Nucleus	Omenn syndrome;Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-positive;Combined cellular and humoral immune defects with granulomas	Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity).	NA	Belongs to the RAG2 family.	Primary immunodeficiency;MAPK6/MAPK4 signaling;Interleukin-7 signaling	PE1	11
+NX_P55899	IgG receptor FcRn large subunit p51	365	39743	6.09	1	Endosome membrane;Cell membrane	NA	Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995).;(Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.	NA	Belongs to the immunoglobulin superfamily.	NA	PE1	19
+NX_P55916	Mitochondrial uncoupling protein 3	312	34216	9.31	6	Nucleoplasm;Cytosol;Mitochondrion inner membrane;Cell membrane	Obesity	UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	The fatty acid cycling model;The proton buffering model	PE1	11
+NX_P55957	BH3-interacting domain death agonist	195	21995	5.27	0	Mitochondrion membrane;Cytoplasm;Cytosol;Mitochondrion outer membrane	NA	Induce ICE-like proteases and apoptosis.;The major proteolytic product p15 BID allows the release of cytochrome c (By similarity).;Does not induce apoptosis. Counters the protective effect of Bcl-2.	TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.;P15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.;BID is phosphorylated by MAPK3	NA	p53 signaling pathway;Apoptosis;Natural killer cell mediated cytotoxicity;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Tuberculosis;Pathways in cancer;Viral myocarditis;Activation, myristolyation of BID and translocation to mitochondria;Activation of BAD and translocation to mitochondria;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Activation, translocation and oligomerization of BAX;Activation and oligomerization of BAK protein;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	PE1	22
+NX_P56134	ATP synthase subunit f, mitochondrial	94	10918	9.7	1	Cytoplasm;Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.	NA	Belongs to the ATPase F chain family.	Oxidative phosphorylation;Metabolic pathways;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	7
+NX_P56159	GDNF family receptor alpha-1	465	51456	8.3	0	trans-Golgi network;Golgi apparatus;Cell membrane;Nucleoplasm;Endosome;Multivesicular body	NA	Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).	NA	Belongs to the GDNFR family.	RAF/MAP kinase cascade;NCAM1 interactions;RET signaling	PE1	10
+NX_P56177	Homeobox protein DLX-1	255	27320	9.71	0	Nucleus	NA	Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity).	NA	Belongs to the distal-less homeobox family.	NA	PE1	2
+NX_P56178	Homeobox protein DLX-5	289	31540	9.31	0	Nucleoplasm;Nucleus	Split-hand/foot malformation 1 with sensorineural hearing loss, autosomal recessive	Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.	Phosphorylated. Phosphorylation of Ser-34 and Ser-217 by MAPK14 enhances its transcriptional activity. Phosphorylation by CaMK2 increases its protein stability (By similarity).	Belongs to the distal-less homeobox family.	Regulation of RUNX2 expression and activity	PE1	7
+NX_P56179	Homeobox protein DLX-6	175	19708	9.95	0	Nucleus	NA	NA	NA	Belongs to the distal-less homeobox family.	Regulation of RUNX2 expression and activity	PE1	7
+NX_P56180	Putative tyrosine-protein phosphatase TPTE	551	64322	8.81	3	Membrane	NA	Could be involved in signal transduction.	NA	NA	Synthesis of PIPs at the Golgi membrane	PE1	21
+NX_P56181	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	108	11941	9.72	0	Mitochondrion inner membrane;Mitochondrion	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.	NA	Belongs to the complex I NDUFV3 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	21
+NX_P56182	Ribosomal RNA processing protein 1 homolog A	461	52839	9.39	0	Nucleolus	NA	Plays a critical role in the generation of 28S rRNA.	Methylated at Gln-427 by N6AMT1.	Belongs to the RRP1 family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	21
+NX_P56192	Methionine--tRNA ligase, cytoplasmic	900	101116	5.82	0	Cytosol;Nucleolus	Charcot-Marie-Tooth disease 2U;Interstitial lung and liver disease	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971).	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Selenocompound metabolism;Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation;Selenoamino acid metabolism	PE1	12
+NX_P56199	Integrin alpha-1	1179	130848	5.91	1	Membrane	NA	Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.	NA	Belongs to the integrin alpha chain family.	Focal adhesion;ECM-receptor interaction;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Integrin cell surface interactions;Other semaphorin interactions;CHL1 interactions;Platelet Adhesion to exposed collagen;Smooth Muscle Contraction;Laminin interactions	PE1	5
+NX_P56202	Cathepsin W	376	42120	7.14	0	Endoplasmic reticulum	NA	May have a specific function in the mechanism or regulation of T-cell cytolytic activity.;(Microbial infection) Plays a role during influenza virus infection in lungs cells ex vivo. Acts at the level of virus entering host cytoplasm from late endosome.	NA	Belongs to the peptidase C1 family.	Lysosome;Platelet degranulation	PE1	11
+NX_P56211	cAMP-regulated phosphoprotein 19	112	12323	9.07	0	Cytoplasm	NA	Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.	Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.	Belongs to the endosulfine family.	MASTL Facilitates Mitotic Progression	PE1	15
+NX_P56270	Myc-associated zinc finger protein	477	48608	9.21	0	Nucleoplasm;Nucleus	NA	May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.	NA	NA	NA	PE1	16
+NX_P56277	Cx9C motif-containing protein 4	68	7747	8.5	0	Cytoplasm;Mitochondrion;Nucleus	NA	NA	NA	Belongs to the CMC4 family.	Mitochondrial protein import	PE1	X
+NX_P56278	Protein p13 MTCP-1	107	12600	5.07	0	Nucleoplasm;Cell membrane	NA	Enhances the phosphorylation and activation of AKT1 and AKT2.	NA	Belongs to the TCL1 family.	NA	PE1	X
+NX_P56279	T-cell leukemia/lymphoma protein 1A	114	13460	4.98	0	Cytoplasm;Microsome;Nucleoplasm;Endoplasmic reticulum;Cytosol;Nucleus	NA	Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.	NA	Belongs to the TCL1 family.	NA	PE1	14
+NX_P56282	DNA polymerase epsilon subunit 2	527	59537	5.95	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity).	NA	Belongs to the DNA polymerase epsilon subunit B family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;HTLV-I infection;Activation of the pre-replicative complex;Termination of translesion DNA synthesis;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Telomere C-strand synthesis initiation;DNA replication initiation;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER	PE1	14
+NX_P56373	P2X purinoceptor 3	397	44289	7.88	2	Cell membrane	NA	Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).	NA	Belongs to the P2X receptor family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Elevation of cytosolic Ca2+ levels;Platelet homeostasis	PE1	11
+NX_P56377	AP-1 complex subunit sigma-2	157	18615	5.39	0	Golgi apparatus;Cytoplasmic vesicle membrane;Clathrin-coated pit	Pettigrew syndrome	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	NA	Belongs to the adaptor complexes small subunit family.	Lysosome;MHC class II antigen presentation;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Nef mediated downregulation of MHC class I complex cell surface expression	PE1	X
+NX_P56378	ATP synthase subunit ATP5MPL, mitochondrial	58	6662	10.08	1	Mitochondrion membrane;Cytoplasm;Mitochondrion;Nucleolus	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). Minor subunit required to maintain the ATP synthase population in the mitochondria (PubMed:24330338).	NA	Belongs to the small mitochondrial proteolipid family.	NA	PE1	14
+NX_P56381	ATP synthase subunit epsilon, mitochondrial	51	5780	9.93	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex V deficiency, nuclear type 3	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).	NA	Belongs to the eukaryotic ATPase epsilon family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	20
+NX_P56385	ATP synthase subunit e, mitochondrial	69	7933	9.34	0	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.	NA	Belongs to the ATPase e subunit family.	Oxidative phosphorylation;Metabolic pathways;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	4
+NX_P56470	Galectin-4	323	35941	9.21	0	Cell membrane	NA	Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.	NA	NA	NA	PE1	19
+NX_P56524	Histone deacetylase 4	1084	119040	6.49	0	Cytoplasm;Nucleus speckle;Nucleoplasm;Cytosol;Nucleus	Brachydactyly-mental retardation syndrome	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).	Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues by CaMK2D is required for the interaction with 14-3-3. Phosphorylation at Ser-350, within the PxLPxI/L motif, impairs the binding of ANKRA2 but generates a high-affinity docking site for 14-3-3.;Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.	Belongs to the histone deacetylase family. HD type 2 subfamily.	Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;SUMOylation of chromatin organization proteins;RUNX3 regulates p14-ARF;RUNX2 regulates chondrocyte maturation;SUMOylation of intracellular receptors	PE1	2
+NX_P56537	Eukaryotic translation initiation factor 6	245	26599	4.56	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).	Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.	Belongs to the eIF-6 family.	Ribosome biogenesis in eukaryotes	PE1	20
+NX_P56539	Caveolin-3	151	17259	5.5	0	Cell membrane;Caveola;Golgi apparatus membrane;Cytoplasmic vesicle;Sarcolemma	Long QT syndrome 9;Cardiomyopathy, familial hypertrophic;Myopathy, distal, Tateyama type;HyperCKmia;Sudden infant death syndrome;Rippling muscle disease 2	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (PubMed:19262564).	Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.	Belongs to the caveolin family.	Endocytosis;Focal adhesion;Bacterial invasion of epithelial cells;Smooth Muscle Contraction	PE1	3
+NX_P56545	C-terminal-binding protein 2	445	48945	6.47	0	Cytosol;Synapse;Nucleus	NA	Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).;Probably acts as a scaffold for specialized synapses.	NA	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Wnt signaling pathway;Notch signaling pathway;Pathways in cancer;Chronic myeloid leukemia;Repression of WNT target genes;TCF7L2 mutants don't bind CTBP	PE1	10
+NX_P56555	Down syndrome critical region protein 4	118	12955	7.76	0	NA	NA	NA	NA	NA	NA	PE2	21
+NX_P56556	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	128	15137	9.98	0	Mitochondrion inner membrane	Mitochondrial complex I deficiency, nuclear type 33	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly (PubMed:30245030). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I LYR family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	22
+NX_P56557	Transmembrane protein 50B	158	17936	5.23	4	Golgi apparatus;Endoplasmic reticulum membrane;Nucleolus;Golgi apparatus membrane	NA	NA	NA	Belongs to the UPF0220 family.	NA	PE1	21
+NX_P56559	ADP-ribosylation factor-like protein 4C	192	21487	9.17	0	Cytoplasm;Cytosol;Filopodium;Cell membrane	NA	Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	2
+NX_P56589	Peroxisomal biogenesis factor 3	373	42140	8.37	2	Peroxisome membrane;Nucleoplasm;Peroxisome	Peroxisome biogenesis disorder 10A;Peroxisome biogenesis disorder complementation group 12;Peroxisome biogenesis disorder 10B	Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.	NA	Belongs to the peroxin-3 family.	Peroxisome;ABC transporters in lipid homeostasis;Class I peroxisomal membrane protein import	PE1	6
+NX_P56597	Nucleoside diphosphate kinase homolog 5	212	24236	5.89	0	Nucleoplasm;Nucleus	NA	Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).	NA	Belongs to the NDK family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways	PE1	5
+NX_P56645	Period circadian protein homolog 3	1201	131888	6.44	0	Cytoplasm;Cytosol;Nucleus	Advanced sleep phase syndrome, familial, 3	Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme.	Ubiquitinated.;Phosphorylation by CSNK1E is weak and appears to require association with PER1 and translocation to the nucleus.	NA	Circadian rhythm - mammal;Herpes simplex infection	PE1	1
+NX_P56693	Transcription factor SOX-10	466	49911	6.19	0	Mitochondrion outer membrane;Cytoplasm;Nucleoplasm;Nucleus	Peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome and Hirschsprung disease;Waardenburg syndrome 2E;Waardenburg syndrome 4C	Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087).	NA	NA	NA	PE1	22
+NX_P56696	Potassium voltage-gated channel subfamily KQT member 4	695	77101	9.6	6	Basal cell membrane	Deafness, autosomal dominant, 2A	Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.	NA	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily.	Cholinergic synapse;Voltage gated Potassium channels	PE1	1
+NX_P56703	Proto-oncogene Wnt-3	355	39645	7.47	0	Extracellular matrix;Secreted	Tetraamelia syndrome 1	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406).	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors);TCF dependent signaling in response to WNT	PE1	17
+NX_P56704	Protein Wnt-3a	352	39365	8.52	0	Extracellular matrix;Secreted	NA	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720).	Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT3A.;Disulfide bonds have critical and distinct roles in secretion and activity. Loss of each conserved cysteine in WNT3A results in high molecular weight oxidized Wnt oligomers, which are formed through inter-Wnt disulfide bonding.;Palmitoleoylation by PORCN is required for efficient binding to frizzled receptors. Palmitoleoylation is required for proper trafficking to cell surface, vacuolar acidification is critical to release palmitoleoylated WNT3A from WLS in secretory vesicles (PubMed:20826466, PubMed:21244856, PubMed:24292069). Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway, possibly by promoting disulfide bond formation and oligomerization (PubMed:25731175).	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors);TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;Regulation of FZD by ubiquitination;RNF mutants show enhanced WNT signaling and proliferation;Disassembly of the destruction complex and recruitment of AXIN to the membrane	PE1	1
+NX_P56705	Protein Wnt-4	351	39052	8.92	0	Cytoplasmic vesicle;Extracellular matrix	46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs;Mullerian aplasia and hyperandrogenism	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:15317892, PubMed:16959810, PubMed:18179883, PubMed:18182450). Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity).	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors);TCF dependent signaling in response to WNT;PCP/CE pathway;Negative regulation of TCF-dependent signaling by WNT ligand antagonists	PE1	1
+NX_P56706	Protein Wnt-7b	349	39327	9.11	0	Extracellular matrix;Secreted	NA	Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314).	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors)	PE1	22
+NX_P56715	Oxygen-regulated protein 1	2156	240661	5.55	0	Photoreceptor outer segment;Cilium axoneme	Retinitis pigmentosa 1	Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme (By similarity).	NA	NA	NA	PE1	8
+NX_P56730	Neurotrypsin	875	97067	8.41	0	Nucleoplasm;Secreted;Cytoskeleton	Mental retardation, autosomal recessive 1	Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.	NA	Belongs to the peptidase S1 family.	NA	PE1	4
+NX_P56746	Claudin-15	228	24356	5.61	4	Tight junction;Cell membrane	NA	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake.	Palmitoylated.	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	7
+NX_P56747	Claudin-6	220	23292	8.32	4	Tight junction;Cell membrane	NA	(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.;Plays a major role in tight junction-specific obliteration of the intercellular space.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	16
+NX_P56748	Claudin-8	225	24845	9	4	Tight junction;Cell membrane	NA	Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation.	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	21
+NX_P56749	Claudin-12	244	27110	8.8	4	Tight junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	Tight junction interactions	PE1	7
+NX_P56750	Claudin-17	224	24603	9.8	4	Tight junction;Cell membrane	NA	Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	21
+NX_P56817	Beta-secretase 1	501	55764	5.31	1	trans-Golgi network;Cell membrane;Recycling endosome;Early endosome;Cell surface;Cytoplasmic vesicle membrane;Endosome;Endoplasmic reticulum;Late endosome;Lysosome;Dendrite;Axon;Membrane raft	NA	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142). Cleaves CHL1 (By similarity).	Phosphorylation at Ser-498 is required for interaction with GGA1 and retrograded transport from endosomal compartments to the trans-Golgi network. Non-phosphorylated BACE1 enters a direct recycling route to the cell surface.;Acetylated in the endoplasmic reticulum at Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300 and Lys-307. Acetylation by NAT8 and NAT8B is transient and deacetylation probably occurs in the Golgi. Acetylation regulates the maturation, the transport to the plasma membrane, the stability and the expression of the protein.;N-Glycosylated (PubMed:11083922, PubMed:17425515). Addition of a bisecting N-acetylglucosamine by MGAT3 blocks lysosomal targeting, further degradation and is required for maintaining stability under stress conditions (By similarity).;Palmitoylation mediates lipid raft localization.;Ubiquitinated at Lys-501, ubiquitination leads to lysosomal degradation (PubMed:27302062, PubMed:16033761, PubMed:20484053, PubMed:23109336). Monoubiquitinated and 'Lys-63'-linked polyubitinated (PubMed:20484053). Deubiquitnated by USP8; inhibits lysosomal degradation (PubMed:27302062).	Belongs to the peptidase A1 family.	Alzheimer's disease;Amyloid fiber formation	PE1	11
+NX_P56851	Epididymal secretory protein E3-beta	147	17584	6.51	0	Secreted	NA	Possible function in sperm maturation.	NA	NA	NA	PE1	14
+NX_P56856	Claudin-18	261	27856	8.39	4	Tight junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	3
+NX_P56880	Claudin-20	219	23515	6.98	4	Tight junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE2	6
+NX_P56915	Homeobox protein goosecoid	257	28150	8.86	0	Nucleus	Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities	Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.	NA	Belongs to the paired homeobox family. Bicoid subfamily.	NA	PE1	14
+NX_P56937	3-keto-steroid reductase	341	38206	8.35	1	Cell membrane	NA	Responsible for the reduction of the keto group on the C-3 of sterols.	Phosphorylated.	Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.	Steroid biosynthesis; estrogen biosynthesis.;Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.;Steroid biosynthesis;Steroid hormone biosynthesis;Metabolic pathways;Cholesterol biosynthesis	PE1	1
+NX_P56945	Breast cancer anti-estrogen resistance protein 1	870	93372	5.41	0	Cytoplasm;Cytosol;Focal adhesion;Cell membrane	NA	Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.	Dephosphorylated by PTPN14 at Tyr-128.;PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix.;BCAR1 is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255);BCAR1 is phosphorylated by BMX (Phosphotyrosine:PTM-0255)	Belongs to the CAS family.	Chemokine signaling pathway;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;VEGFA-VEGFR2 Pathway;Downstream signal transduction;p130Cas linkage to MAPK signaling for integrins;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	PE1	16
+NX_P56962	Syntaxin-17	302	33403	6.14	2	Autophagosome membrane;Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane;Smooth endoplasmic reticulum membrane;Nucleolus;COPII-coated vesicle membrane;Cytosol	NA	SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502). STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).	Phosphorylated at Tyr-157 probably by ABL1. Dephosphorylation by PTPN2; regulates exit from the endoplasmic reticulum (By similarity).	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;COPII-mediated vesicle transport	PE1	9
+NX_P56975	Pro-neuregulin-3, membrane-bound isoform	720	77901	7.79	1	Cytoplasmic vesicle;Secreted;Cell membrane	NA	Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.	Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.;Extensive glycosylation precedes the proteolytic cleavage (By similarity).;Is glycosylated.	Belongs to the neuregulin family.	ErbB signaling pathway;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;PI3K events in ERBB4 signaling;SHC1 events in ERBB4 signaling;Nuclear signaling by ERBB4;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling	PE1	10
+NX_P57052	Splicing regulator RBM11	281	32179	8.87	0	Nucleoplasm;Nucleus speckle	NA	Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.	NA	NA	NA	PE1	21
+NX_P57053	Histone H2B type F-S	126	13944	10.37	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.;Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.	Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.;GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.	Belongs to the histone H2B family.	Transcriptional regulation by small RNAs;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	21
+NX_P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	158	18089	8.8	2	Membrane;Cytoplasmic vesicle	Epileptic encephalopathy, early infantile, 55	Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.	NA	Belongs to the PIGP family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	21
+NX_P57055	Protein ripply3	190	20368	5.98	0	Nucleus	NA	Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity).	NA	Belongs to the ripply family.	NA	PE1	21
+NX_P57057	Glucose-6-phosphate exchanger SLC37A1	533	57648	8.61	12	Endoplasmic reticulum membrane	NA	Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.	NA	Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.	Gluconeogenesis	PE1	21
+NX_P57058	Hormonally up-regulated neu tumor-associated kinase	714	79686	9.24	0	Nucleoplasm;Cell membrane	NA	NA	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	NA	PE1	21
+NX_P57059	Serine/threonine-protein kinase SIK1	783	84902	6.81	0	Cytoplasm;Nucleus	Epileptic encephalopathy, early infantile, 30	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).	Phosphorylated at Thr-182 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39, leading to its activation. Phosphorylation at Thr-182 promotes autophosphorylation at Ser-186, which is required for sustained activity. Autophosphorylation at Ser-186 is maintained by sequential phosphorylation at Thr-182 by GSK3-beta. GSK3-beta cannot initiate phosphorylation at Thr-182, it can only maintain it. Phosphorylation at Ser-575 in response to cAMP signaling promotes translocation to the cytoplasm (PubMed:29211348). Phosphorylation at Thr-322 by CaMK1 following intracellular sodium concentration leads to activation.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.	Circadian Clock	PE1	21
+NX_P57060	RWD domain-containing protein 2B	319	36332	5.61	0	NA	NA	NA	NA	NA	NA	PE1	21
+NX_P57071	PR domain zinc finger protein 15	1507	169269	8.59	0	Nucleoplasm;Nucleus	NA	Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264).	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE1	21
+NX_P57073	Transcription factor SOX-8	446	47314	6.49	0	Nucleoplasm;Nucleus	NA	May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).	NA	NA	NA	PE1	16
+NX_P57075	Ubiquitin-associated and SH3 domain-containing protein A	661	74123	7.77	0	Golgi apparatus;Nucleoplasm;Cytoplasm;Nucleus	NA	Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.	NA	NA	NA	PE1	21
+NX_P57076	Cilia- and flagella-associated protein 298	290	33224	6.99	0	Cytoplasm;Cilium basal body	Ciliary dyskinesia, primary, 26	Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744). Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity).	NA	Belongs to the CFAP298 family.	NA	PE1	21
+NX_P57077	MAP3K7 C-terminal-like protein	242	27248	4.81	0	Cytoplasm;Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	21
+NX_P57078	Receptor-interacting serine/threonine-protein kinase 4	832	91611	6.69	0	Membrane;Cytoplasm	Bartsocas-Papas syndrome;CHAND syndrome	Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.	May be phosphorylated by MAP3K2 and MAP3K3.;Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.;Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426.;RIPK4 is phosphorylated by PRKCB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	NA	PE1	21
+NX_P57081	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4	412	45490	6.71	0	Nucleoplasm;Cytosol;Nucleus;Chromosome	Galloway-Mowat syndrome 6;Microcephaly, growth deficiency, seizures, and brain malformations	Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit (PubMed:12403464). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069).	NA	Belongs to the WD repeat TRM82 family.	tRNA modification; N(7)-methylguanine-tRNA biosynthesis.;tRNA modification in the nucleus and cytosol	PE1	21
+NX_P57082	T-box transcription factor TBX4	545	60204	7.34	0	Cytoplasmic vesicle;Nucleus	Ischiocoxopodopatellar syndrome	Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.	NA	NA	NA	PE1	17
+NX_P57086	SCAN domain-containing protein 1	179	19082	9.73	0	Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	May regulate transcriptional activity.	NA	NA	NA	PE1	20
+NX_P57087	Junctional adhesion molecule B	298	33207	9.23	1	Nucleoplasm;Tight junction;Cell membrane	NA	May play a role in the processes of lymphocyte homing to secondary lymphoid organs.	NA	Belongs to the immunoglobulin superfamily.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Epithelial cell signaling in Helicobacter pylori infection;Integrin cell surface interactions;Cell surface interactions at the vascular wall	PE1	21
+NX_P57088	Transmembrane protein 33	247	27978	9.76	3	Endoplasmic reticulum membrane;Nucleus envelope;Melanosome	NA	Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696).	NA	Belongs to the PER33/POM33 family.	NA	PE1	4
+NX_P57103	Sodium/calcium exchanger 3	927	103010	5.01	11	Mitochondrion outer membrane;Dendritic spine;Endoplasmic reticulum membrane;Cell membrane;Cell junction;Perikaryon;Sarcoplasm;Sarcolemma;Dendrite;Perinuclear region	NA	Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity).	NA	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.	Calcium signaling pathway;Protein digestion and absorption;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis;Mitochondrial calcium ion transport	PE1	14
+NX_P57105	Synaptojanin-2-binding protein	145	15928	5.86	1	Mitochondrion outer membrane;Mitochondrion	NA	Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.	NA	NA	NA	PE1	14
+NX_P57678	Gem-associated protein 4	1058	120037	5.7	0	Cytoplasm;Gem;Nucleolus;Cytosol;Nucleus	Neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.	NA	NA	RNA transport;snRNP Assembly	PE1	17
+NX_P57679	Ellis-van Creveld syndrome protein	992	111990	6.29	1	Cell membrane;Cilium;Cilium basal body;Nucleoplasm;Cilium membrane;Cytosol	Ellis-van Creveld syndrome;Acrofacial dysostosis, Weyers type	Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development.	NA	NA	Hedgehog 'on' state;Activation of SMO	PE1	4
+NX_P57682	Krueppel-like factor 3	345	38829	9.44	0	Nucleoplasm;Nucleus	NA	Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity).	Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-198 is the major site (By similarity).	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	4
+NX_P57721	Poly(rC)-binding protein 3	371	39465	8.22	0	Nucleoplasm;Cytoplasm;Mitochondrion;Cytoplasmic vesicle	NA	Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.	NA	NA	NA	PE1	21
+NX_P57723	Poly(rC)-binding protein 4	403	41482	8.42	0	Cytoplasm;Cytosol	NA	Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.	NA	NA	Transcriptional activation of cell cycle inhibitor p21;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;FOXO-mediated transcription of cell cycle genes	PE1	3
+NX_P57727	Transmembrane protease serine 3	454	49405	5.95	1	Endoplasmic reticulum membrane	Deafness, autosomal recessive, 8	Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).	Undergoes autoproteolytic activation.	Belongs to the peptidase S1 family.	NA	PE1	21
+NX_P57729	Ras-related protein Rab-38	211	23712	7.65	0	Mitochondrion;Cell membrane;Phagosome membrane;Melanosome;Phagosome;Melanosome membrane;Nucleus	NA	May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).	Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated.	Belongs to the small GTPase superfamily. Rab family.	RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	11
+NX_P57730	Caspase recruitment domain-containing protein 18	90	10138	6.27	0	NA	NA	Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.	NA	NA	NOD-like receptor signaling pathway	PE1	11
+NX_P57735	Ras-related protein Rab-25	213	23496	5.72	0	Cell membrane;Cell junction;Cytoplasmic vesicle;Cytosol;Pseudopodium membrane	NA	Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).	NA	Belongs to the small GTPase superfamily. Rab family.	RAB geranylgeranylation	PE1	1
+NX_P57737	Coronin-7	925	100605	5.51	0	trans-Golgi network;Cytoplasmic vesicle;Cytosol;Golgi apparatus membrane	NA	F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.	The membrane-associated form is phosphorylated on tyrosine residues.;Ubiquitinated via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: 'Lys-33'-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID.	Belongs to the WD repeat coronin family.	NA	PE1	16
+NX_P57738	T-cell leukemia translocation-altered gene protein	103	11341	5.51	2	Membrane;Cytosol	NA	May be required for cellular fusion during osteoclastogenesis.	NA	Belongs to the TCTA family.	NA	PE1	3
+NX_P57739	Claudin-2	230	24549	8.47	4	Nucleoplasm;Tight junction;Cell junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking.	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	X
+NX_P57740	Nuclear pore complex protein Nup107	925	106374	5.28	0	Nuclear pore complex;Nucleus membrane;Nucleoplasm;Centrosome;Kinetochore	Nephrotic syndrome 11;Galloway-Mowat syndrome 7;Ovarian dysgenesis 6	Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222).	NA	Belongs to the nucleoporin Nup84/Nup107 family.	RNA transport;Separation of Sister Chromatids;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	12
+NX_P57764	Gasdermin-D	484	52801	5	0	Inflammasome;Cell membrane;Secreted;Nucleoplasm;Cytosol	NA	Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter, possibly allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190, PubMed:27281216). Exhibits bactericidal activity. Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216).	Cleavage at Asp-275 by CASP1 (mature and uncleaved precursor forms) or CASP4 relieves autoinhibition and is sufficient to initiate pyroptosis (PubMed:26375003). Cleavage at Asp-87 by CASP3 (PubMed:28045099).	Belongs to the gasdermin family.	Neutrophil degranulation	PE1	8
+NX_P57768	Sorting nexin-16	344	39167	4.59	0	Cytoplasm;Lysosome;Early endosome membrane;Cytoplasmic vesicle;Late endosome membrane	NA	May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.	NA	Belongs to the sorting nexin family.	NA	PE1	8
+NX_P57771	Regulator of G-protein signaling 8	180	20917	9.36	0	Cell membrane;Perikaryon;Membrane;Dendrite;Nucleus	NA	Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).	NA	NA	G alpha (i) signalling events	PE1	1
+NX_P57772	Selenocysteine-specific elongation factor	596	65305	8.61	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.	Selenocysteine synthesis	PE1	3
+NX_P57773	Gap junction alpha-9 protein	515	58842	8.67	4	Gap junction;Cell membrane	NA	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Alpha-type (group II) subfamily.	Gap junction assembly	PE2	1
+NX_P57775	F-box/WD repeat-containing protein 4	412	46337	7.54	0	Golgi apparatus	Split-hand/foot malformation 3	Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Association of TriC/CCT with target proteins during biosynthesis;Neddylation	PE1	10
+NX_P57789	Potassium channel subfamily K member 10	538	59765	8.9	4	Membrane	NA	Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.	NA	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Gastric acid secretion;TWIK related potassium channel (TREK);Phase 4 - resting membrane potential	PE1	14
+NX_P57796	Calcium-binding protein 4	275	30433	5.27	0	Cytoplasm;Presynapse	Cone-rod synaptic disorder, congenital non-progressive	Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).	Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity (By similarity).	NA	NA	PE1	11
+NX_P58004	Sestrin-2	480	54494	5.57	0	Cytoplasm;Cytosol	NA	Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821).	Phosphorylated by ULK1 at multiple sites.	Belongs to the sestrin family.	p53 signaling pathway;TP53 Regulates Metabolic Genes	PE1	1
+NX_P58005	Sestrin-3	492	57291	5.84	0	Nucleoplasm;Cytosol;Cytoplasm	NA	May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).	NA	Belongs to the sestrin family.	p53 signaling pathway;TP53 Regulates Metabolic Genes	PE1	11
+NX_P58012	Forkhead box protein L2	376	38772	9.26	0	Nucleoplasm;Nucleus;Cytoskeleton	Premature ovarian failure 3;Blepharophimosis, ptosis, and epicanthus inversus syndrome	Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.	Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.;FOXL2 is phosphorylated by LATS1 (Phosphoserine:PTM-0253)	NA	SUMOylation of transcription factors	PE1	3
+NX_P58062	Serine protease inhibitor Kazal-type 7	85	9232	7.52	0	Secreted	NA	Probable serine protease inhibitor.	NA	NA	NA	PE1	5
+NX_P58107	Epiplakin	5088	555658	5.45	0	Basolateral cell membrane;Apicolateral cell membrane;Cell junction;Hemidesmosome;Cell projection;Tight junction;Cytoskeleton	NA	Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity).	NA	Belongs to the plakin or cytolinker family.	NA	PE1	8
+NX_P58166	Inhibin beta E chain	350	38561	9.49	0	Cytoplasmic vesicle;Secreted	NA	Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.	NA	Belongs to the TGF-beta family.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Glycoprotein hormones	PE1	12
+NX_P58170	Olfactory receptor 1D5	312	35424	8.76	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	17
+NX_P58173	Olfactory receptor 2B6	313	35414	8.64	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_P58180	Olfactory receptor 4D2	307	34958	9.1	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	17
+NX_P58181	Olfactory receptor 10A3	314	35535	8.87	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_P58182	Olfactory receptor 12D2	307	34813	8.79	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_P58215	Lysyl oxidase homolog 3	753	83166	6.4	0	Cytoplasm;Nucleus;Extracellular space	NA	Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII (PubMed:17018530).;Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed:17018530).;Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600).	The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.	Belongs to the lysyl oxidase family.	Elastic fibre formation;Crosslinking of collagen fibrils	PE1	2
+NX_P58294	Prokineticin-1	105	11715	9.01	0	Secreted	NA	Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.	NA	Belongs to the AVIT (prokineticin) family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	1
+NX_P58304	Visual system homeobox 2	361	39411	7.11	0	Nucleus	Microphthalmia with cataracts and iris abnormalities;Microphthalmia, isolated, 2;Microphthalmia, isolated, with coloboma, 3	Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters (PubMed:27301076). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1 (PubMed:17919464, PubMed:27477290). Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1 (By similarity). Acts as a negative transcriptional regulator of MITF (By similarity). Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements (PubMed:16236706, PubMed:27477290). Binds to the photoreceptor conserved element-1 (PCE-1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells (By similarity). Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation (By similarity). May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling (PubMed:27301076).	NA	Belongs to the paired homeobox family.	NA	PE1	14
+NX_P58317	Zinc finger protein 121	390	44694	8.37	0	Nucleoplasm;Nucleolus;Centrosome;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_P58335	Anthrax toxin receptor 2	489	53666	7.42	1	Endoplasmic reticulum membrane;Secreted;Cell membrane	Hyaline fibromatosis syndrome	Necessary for cellular interactions with laminin and the extracellular matrix.	NA	Belongs to the ATR family.	Uptake and function of anthrax toxins	PE1	4
+NX_P58340	Myeloid leukemia factor 1	268	30627	9.46	0	Cytoplasm;Cilium;Cilium basal body;Nucleoplasm;Cytosol;Nucleus	NA	Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.	Phosphorylation is required for binding to YWHAZ.	Belongs to the MLF family.	NA	PE1	3
+NX_P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	1594	177676	8.25	0	Extracellular matrix;Mitochondrion;Nucleolus	NA	Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.	The precursor is cleaved by a furin endopeptidase.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).;Subjected to an intracellular maturation process yielding a 120 kDa N-terminal fragment containing the metalloproteinase, disintegrin, one TSP type-1 and the Cys-rich domains and a 83 kDa C-terminal fragment containing the spacer 2 and four TSP type-1 domains.	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	5
+NX_P58400	Neurexin-1-beta	472	50424	8.19	1	Presynaptic cell membrane	NA	Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).	Highly O-glycosylated and minor N-glycosylated.	Belongs to the neurexin family.	Cell adhesion molecules (CAMs);Neurexins and neuroligins	PE1	2
+NX_P58401	Neurexin-2-beta	666	70927	5.96	1	Membrane	NA	Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.	NA	Belongs to the neurexin family.	Cell adhesion molecules (CAMs);Neurexins and neuroligins	PE1	11
+NX_P58417	Neurexophilin-1	271	31082	8.86	0	Secreted	NA	May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.	NA	Belongs to the neurexophilin family.	NA	PE1	7
+NX_P58418	Clarin-1	232	25719	8.8	4	Cell membrane	Retinitis pigmentosa 61;Usher syndrome 3A	May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina.	NA	Belongs to the clarin family.	NA	PE1	3
+NX_P58499	Protein FAM3B	235	25982	8.97	0	Cytoplasmic vesicle;Secreted	NA	Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.	O-glycosylated.;2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.	Belongs to the FAM3 family.	NA	PE1	21
+NX_P58505	Uncharacterized protein C21orf58	322	35003	10.06	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	21
+NX_P58511	Small integral membrane protein 11A	58	6886	9.87	1	Membrane;Focal adhesion	NA	NA	NA	Belongs to the SMIM11 family.	NA	PE1	21
+NX_P58512	Uncharacterized protein encoded by LINC01547	204	21308	5.95	0	NA	NA	NA	NA	NA	NA	PE2	21
+NX_P58513	Putative uncharacterized protein encoded by LINC00158	81	9586	9.89	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_P58546	Myotrophin	118	12895	5.27	0	Cytoplasm;Cell membrane;Cytosol;Perinuclear region;Nucleus	NA	Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.	NA	Belongs to the myotrophin family.	NA	PE1	7
+NX_P58549	FXYD domain-containing ion transport regulator 7	80	8524	8.5	1	Membrane	NA	NA	NA	Belongs to the FXYD family.	Ion transport by P-type ATPases;Ion homeostasis	PE1	19
+NX_P58550	Putative FXYD domain-containing ion transport regulator 8	94	10590	6.81	1	Membrane	NA	NA	NA	Belongs to the FXYD family.	NA	PE5	X
+NX_P58557	Endoribonuclease YbeY	167	19298	7.06	0	Nucleoplasm;Nucleus	NA	Single strand-specific metallo-endoribonuclease involved in rRNA maturation.	NA	Belongs to the endoribonuclease YbeY family.	NA	PE1	21
+NX_P58658	Protein eva-1 homolog C	441	49483	6.52	1	Membrane	NA	Binds heparin.	NA	Belongs to the EVA1 family.	NA	PE1	21
+NX_P58743	Prestin	744	81264	5.91	12	Cell membrane	Deafness, autosomal recessive, 61	Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).	NA	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	NA	PE2	7
+NX_P58753	Toll/interleukin-1 receptor domain-containing adapter protein	221	23883	7.56	0	Cytoplasm;Cell membrane;Membrane;Nucleoplasm;Cytosol;Cytoskeleton	NA	Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.	Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK.;Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation.	NA	Toll-like receptor signaling pathway;Pertussis;Tuberculosis;ER-Phagosome pathway;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4)	PE1	11
+NX_P58872	Rhomboid-related protein 3	404	45245	7.25	7	Membrane	NA	May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.	NA	Belongs to the peptidase S54 family.	NA	PE1	17
+NX_P58876	Histone H2B type 1-D	126	13936	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	ADP-ribosylated on Ser-7 in response to DNA damage.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.;GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_P59020	Down syndrome critical region protein 9	149	16743	11.26	0	NA	NA	NA	NA	NA	NA	PE2	21
+NX_P59022	Down syndrome critical region protein 10	87	9286	5.35	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_P59025	Receptor-transporting protein 1	263	30913	7.99	1	Cell membrane	NA	Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.	NA	Belongs to the TMEM7 family.	Olfactory Signaling Pathway	PE1	3
+NX_P59036	Putative uncharacterized protein encoded by LINC00310	64	7298	11.56	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_P59037	Putative uncharacterized protein encoded by LINC00313	77	8510	7.58	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_P59044	NACHT, LRR and PYD domains-containing protein 6	892	98768	8.43	0	Cytoplasm;Inflammasome;Nucleus membrane;Cell membrane	NA	As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity).	NA	Belongs to the NLRP family.	NA	PE1	11
+NX_P59045	NACHT, LRR and PYD domains-containing protein 11	1033	117779	7.98	0	Cytosol	NA	Involved in inflammation.	NA	Belongs to the NLRP family.	NA	PE1	19
+NX_P59046	NACHT, LRR and PYD domains-containing protein 12	1061	120173	6.59	0	Cytoplasm;Nucleoplasm;Nucleus speckle	Familial cold autoinflammatory syndrome 2	Plays an essential role as an potent mitigator of inflammation (PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (PubMed:30902577). Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity).	NA	Belongs to the NLRP family.	NA	PE1	19
+NX_P59047	NACHT, LRR and PYD domains-containing protein 5	1200	134342	6.08	0	Cytoplasm;Mitochondrion;Nucleolus	NA	As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.	NA	Belongs to the NLRP family.	NA	PE1	19
+NX_P59051	Putative uncharacterized protein encoded by BRWD1-AS2	145	16132	12.1	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_P59052	Putative uncharacterized protein B3GALT5-AS1	145	15706	9.21	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_P59074	Putative charged multivesicular body protein 4B-like protein CHMP4BP1	171	19069	5.17	0	NA	NA	NA	NA	Belongs to the SNF7 family.	NA	PE5	14
+NX_P59090	Putative uncharacterized protein TSPEAR-AS2	65	7097	9.38	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_P59091	Putative uncharacterized protein encoded by LINC00315	139	15087	9.9	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_P59095	StAR-related lipid transfer protein 6	220	25022	9.36	0	NA	NA	May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).	NA	NA	Pregnenolone biosynthesis	PE1	18
+NX_P59103	D-amino acid oxidase activator	153	18108	8.73	0	Golgi apparatus	Schizophrenia	Seems to activate D-amino acid oxidase.	NA	NA	NA	PE1	13
+NX_P59190	Ras-related protein Rab-15	212	24391	5.53	0	Cytoplasmic vesicle;Centriolar satellite;Cell membrane	NA	May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.	NA	Belongs to the small GTPase superfamily. Rab family.	RAB geranylgeranylation	PE1	14
+NX_P59282	Tubulin polymerization-promoting protein family member 2	170	18503	9.07	0	Cytoplasm	NA	May bind tubulin but has no microtubule bundling activity.	NA	Belongs to the TPPP family.	NA	PE1	14
+NX_P59510	A disintegrin and metalloproteinase with thrombospondin motifs 20	1910	214721	6.98	0	Extracellular matrix	NA	May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.	The precursor is cleaved by a furin endopeptidase.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE2	12
+NX_P59533	Taste receptor type 2 member 38	333	37892	9.6	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	7
+NX_P59534	Taste receptor type 2 member 39	338	38626	9.12	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	7
+NX_P59535	Taste receptor type 2 member 40	323	36812	9.95	7	Membrane	NA	Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	7
+NX_P59536	Taste receptor type 2 member 41	307	35896	9.98	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	7
+NX_P59537	Taste receptor type 2 member 43	309	35599	10.05	7	Cilium membrane;Membrane	NA	Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	12
+NX_P59538	Taste receptor type 2 member 31	309	35278	10.05	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	12
+NX_P59539	Taste receptor type 2 member 45	299	34278	10.06	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	12
+NX_P59540	Taste receptor type 2 member 46	309	35523	9.79	7	Membrane;Cilium membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	12
+NX_P59541	Taste receptor type 2 member 30	319	36874	10.12	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	12
+NX_P59542	Taste receptor type 2 member 19	299	33908	9.97	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	12
+NX_P59543	Taste receptor type 2 member 20	309	35358	10.06	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	12
+NX_P59544	Taste receptor type 2 member 50	299	34558	9.83	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	12
+NX_P59551	Taste receptor type 2 member 60	318	36337	9.94	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	7
+NX_P59646	FXYD domain-containing ion transport regulator 4	89	9373	7.65	1	Membrane	NA	NA	NA	Belongs to the FXYD family.	Aldosterone-regulated sodium reabsorption;Ion transport by P-type ATPases;Ion homeostasis	PE2	10
+NX_P59665	Neutrophil defensin 1	94	10201	6.54	0	Secreted	NA	Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.	Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-ribosylation.;ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.	Belongs to the alpha-defensin family.	Alpha-defensins;Defensins;Neutrophil degranulation	PE1	8
+NX_P59666	Neutrophil defensin 3	94	10245	5.71	0	Secreted	NA	Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.	NA	Belongs to the alpha-defensin family.	Alpha-defensins;Defensins	PE1	8
+NX_P59768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	71	7850	7.78	0	Cytoplasmic vesicle;Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).	NA	Belongs to the G protein gamma family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	14
+NX_P59773	Major intrinsically disordered NOTCH2-binding receptor 1-like	190	21573	7.86	1	Membrane	NA	NA	NA	Belongs to the MINAR family.	NA	PE2	5
+NX_P59780	AP-3 complex subunit sigma-2	193	22017	5.11	0	Golgi apparatus;Cytoplasmic vesicle membrane	NA	Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.	NA	Belongs to the adaptor complexes small subunit family.	Lysosome	PE1	15
+NX_P59796	Glutathione peroxidase 6	221	24971	6.21	0	Secreted	NA	NA	NA	Belongs to the glutathione peroxidase family.	Glutathione metabolism;Arachidonic acid metabolism;Detoxification of Reactive Oxygen Species	PE2	6
+NX_P59797	Selenoprotein V	346	36800	9.68	0	NA	NA	May be involved in a redox-related process.	NA	Belongs to the SelWTH family.	NA	PE1	19
+NX_P59817	Zinc finger protein 280A	542	60816	9.03	0	Nucleoplasm;Nucleus	NA	May function as a transcription factor.	NA	NA	NA	PE1	22
+NX_P59826	BPI fold-containing family B member 3	476	50342	6.27	0	Cytoplasm;Secreted	NA	May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).	NA	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	NA	PE1	20
+NX_P59827	BPI fold-containing family B member 4	614	65055	4.95	0	Cytoplasm;Secreted	NA	May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).	NA	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Antimicrobial peptides	PE1	20
+NX_P59861	Beta-defensin 131A	70	8199	7.59	0	Secreted	NA	Has antibacterial activity (Probable). Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion (PubMed:26649771).	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	4
+NX_P59901	Leukocyte immunoglobulin-like receptor subfamily A member 4	499	55165	8.29	1	Cell membrane	NA	Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760).	NA	NA	Osteoclast differentiation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_P59910	DnaJ homolog subfamily B member 13	316	36118	7.68	0	Flagellum;Cell membrane	Ciliary dyskinesia, primary, 34	Plays a role in the formation of the central complex of ciliary and flagellar axonemes.	NA	NA	NA	PE1	11
+NX_P59922	Putative olfactory receptor 2B8	312	35019	8.89	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	6
+NX_P59923	Zinc finger protein 445	1031	118963	9.5	0	Nucleoplasm;Cytosol;Mitochondrion;Nucleus	NA	Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	3
+NX_P59942	Mitochondrial coiled-coil domain protein 1	119	13259	7.85	0	Mitochondrion	NA	NA	NA	NA	NA	PE2	6
+NX_P59990	Keratin-associated protein 12-1	96	9737	8.22	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 12 family.	Keratinization	PE1	21
+NX_P59991	Keratin-associated protein 12-2	146	14689	8.17	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 12 family.	Keratinization	PE1	21
+NX_P59998	Actin-related protein 2/3 complex subunit 4	168	19667	8.53	0	Cell projection;Nucleus;Cytoskeleton	NA	Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).	NA	Belongs to the ARPC4 family.	Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;EPHB-mediated forward signaling;Clathrin-mediated endocytosis	PE1	3
+NX_P60002	Transcription elongation factor 1 homolog	83	9462	8.24	0	Cytosol;Nucleus	NA	Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.	NA	Belongs to the ELOF1 family.	NA	PE1	19
+NX_P60006	Anaphase-promoting complex subunit 15	121	14281	3.47	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.	NA	Belongs to the APC15 family.	APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	11
+NX_P60008	Spermatid-specific linker histone H1-like protein	231	25632	10.95	0	Nucleus;Chromosome	NA	DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.	NA	Belongs to the histone H1/H5 family.	NA	PE1	17
+NX_P60014	Keratin-associated protein 10-10	251	25571	7.35	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE1	21
+NX_P60022	Beta-defensin 1	68	7420	8.96	0	Membrane;Secreted	NA	Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	8
+NX_P60033	CD81 antigen	236	25809	5.09	4	Basolateral cell membrane;Cell membrane	Immunodeficiency, common variable, 6	(Microbial infection) Specifically required for Plasmodium falciparum infectivity of hepatocytes, controlling sporozoite entry into hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms.;(Microbial infection) Involved in SAMHD1-dependent restriction of HIV-1 replication. May support early replication of both R5- and X4-tropic HIV-1 viruses in T cells, likely via proteasome-dependent degradation of SAMHD1.;(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Association with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.;Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells (PubMed:20237408, PubMed:27881302, PubMed:16449649). Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production (PubMed:15161911, PubMed:20237408). In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype (PubMed:22307619, PubMed:23858057, PubMed:8766544). Present in MHC class II compartments, may also play a role in antigen presentation (PubMed:8409388, PubMed:8766544). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction (By similarity). In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (PubMed:28871089). Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity).	Not glycosylated.;Likely constitutively palmitoylated at low levels. Protein palmitoylation is up-regulated upon coligation of BCR and CD9-C2R-CD81 complexes in lipid rafts.	Belongs to the tetraspanin (TM4SF) family.	B cell receptor signaling pathway;Malaria;Hepatitis C;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of Complement cascade	PE1	11
+NX_P60059	Protein transport protein Sec61 subunit gamma	68	7741	10.01	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER).	NA	Belongs to the SecE/SEC61-gamma family.	Protein export;Protein processing in endoplasmic reticulum;Phagosome;Vibrio cholerae infection;ER-Phagosome pathway;SRP-dependent cotranslational protein targeting to membrane;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	7
+NX_P60153	Inactive ribonuclease-like protein 9	205	24307	6.18	0	Secreted	NA	Does not exhibit any ribonuclease activity.	NA	Belongs to the pancreatic ribonuclease family.	NA	PE1	14
+NX_P60174	Triosephosphate isomerase	286	30791	5.65	0	Nucleoplasm;Cytoplasm;Cytoplasmic vesicle	Triosephosphate isomerase deficiency	It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.;Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.	The initiator methionine for isoform 2 is removed.;TPI1 is phosphorylated by MAPK3	Belongs to the triosephosphate isomerase family.	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.;Carbohydrate biosynthesis; gluconeogenesis.;Glycolysis / Gluconeogenesis;Fructose and mannose metabolism;Inositol phosphate metabolism;Metabolic pathways;Glycolysis;Gluconeogenesis	PE1	12
+NX_P60201	Myelin proteolipid protein	277	30077	8.71	4	Myelin membrane;Cell membrane	Leukodystrophy, hypomyelinating, 1;Spastic paraplegia 2, X-linked	This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.	NA	Belongs to the myelin proteolipid protein family.	NA	PE1	X
+NX_P60228	Eukaryotic translation initiation factor 3 subunit E	445	52221	5.71	0	Cytoplasm;Cytosol;PML body	NA	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924).	NA	Belongs to the eIF-3 subunit E family.	RNA transport;Hepatitis C;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	8
+NX_P60321	Nanos homolog 2	138	15132	9.02	0	Cytoplasm;P-body;Perinuclear region	NA	Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).	NA	Belongs to the nanos family.	NA	PE1	19
+NX_P60323	Nanos homolog 3	173	18844	9.17	0	Golgi apparatus;Cytoplasm;Stress granule;Nucleolus;P-body;Nucleus	NA	Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.	NA	Belongs to the nanos family.	NA	PE1	19
+NX_P60328	Keratin-associated protein 12-3	96	9947	8.02	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 12 family.	Keratinization	PE1	21
+NX_P60329	Keratin-associated protein 12-4	112	11433	7.68	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 12 family.	Keratinization	PE1	21
+NX_P60331	Keratin-associated protein 10-1	282	28660	7.77	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE2	21
+NX_P60368	Keratin-associated protein 10-2	255	25616	7.52	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE2	21
+NX_P60369	Keratin-associated protein 10-3	221	22348	7.99	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE2	21
+NX_P60370	Keratin-associated protein 10-5	271	27626	7.5	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE1	21
+NX_P60371	Keratin-associated protein 10-6	365	36791	6	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE2	21
+NX_P60372	Keratin-associated protein 10-4	401	40429	7.12	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE1	21
+NX_P60409	Keratin-associated protein 10-7	370	37372	7.38	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE1	21
+NX_P60410	Keratin-associated protein 10-8	259	26299	7.82	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE1	21
+NX_P60411	Keratin-associated protein 10-9	292	30037	7.87	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE1	21
+NX_P60412	Keratin-associated protein 10-11	298	30243	7.93	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE1	21
+NX_P60413	Keratin-associated protein 10-12	245	25107	7.94	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 10 family.	Keratinization	PE1	21
+NX_P60468	Protein transport protein Sec61 subunit beta	96	9974	11.57	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis (By similarity).	NA	Belongs to the SEC61-beta family.	Protein export;Protein processing in endoplasmic reticulum;Phagosome;Vibrio cholerae infection;ER-Phagosome pathway;SRP-dependent cotranslational protein targeting to membrane;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	9
+NX_P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	403	47166	5.94	0	Cytoplasm;Secreted;Nucleoplasm;PML body;Cytosol;Nucleus	Macrocephaly/autism syndrome;Prostate cancer;Endometrial cancer;Squamous cell carcinoma of the head and neck;Lhermitte-Duclos disease;Cowden syndrome 1;Glioma 2	Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226, PubMed:16824732). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.;Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.	Monoubiquitinated; monoubiquitination is increased in presence of retinoic acid. Deubiquitinated by USP7; leading to its nuclear exclusion. Monoubiquitination of one of either Lys-13 and Lys-289 amino acid is sufficient to modulate PTEN compartmentalization. Ubiquitinated by XIAP/BIRC4.;Constitutively phosphorylated by CK2 under normal conditions. Phosphorylated in vitro by MAST1, MAST2, MAST3 and STK11. Phosphorylation results in an inhibited activity towards PIP3. Phosphorylation can both inhibit or promote PDZ-binding. Phosphorylation at Tyr-336 by FRK/PTK5 protects this protein from ubiquitin-mediated degradation probably by inhibiting its binding to NEDD4. Phosphorylation by ROCK1 is essential for its stability and activity. Phosphorylation by PLK3 promotes its stability and prevents its degradation by the proteasome.;PTEN is phosphorylated by MAST3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PTEN is phosphorylated by MAST1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PTEN is phosphorylated by MAST2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the PTEN phosphatase protein family.	Inositol phosphate metabolism;Phosphatidylinositol signaling system;p53 signaling pathway;Focal adhesion;Tight junction;Pathways in cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Small cell lung cancer;Synthesis of PIPs at the plasma membrane;Downstream TCR signaling;TP53 Regulates Metabolic Genes;Synthesis of IP3 and IP4 in the cytosol;Negative regulation of the PI3K/AKT network;PTEN Loss of Function in Cancer;Ub-specific processing proteases;Ovarian tumor domain proteases;Regulation of PTEN stability and activity;Regulation of PTEN localization;Regulation of PTEN mRNA translation;Transcriptional Regulation by MECP2	PE1	10
+NX_P60507	Endogenous retrovirus group FC1 Env polyprotein	584	65248	8.56	1	Virion;Cell membrane	NA	SU mediates receptor recognition.;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.;TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).	The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein (By similarity).;Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the gamma type-C retroviral envelope protein family. HERV class-I F(c)1 env subfamily.	NA	PE1	X
+NX_P60508	Syncytin-2	538	59523	9.14	1	Virion;Cell membrane	NA	This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732).;Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139).	The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity).;Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily.	NA	PE1	6
+NX_P60509	Endogenous retrovirus group PABLB member 1 Env polyprotein	514	58521	7.61	1	Cell membrane	NA	Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.	The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane domain (By similarity).	Belongs to the gamma type-C retroviral envelope protein family. HERV class-I R(b) env subfamily.	NA	PE2	3
+NX_P60510	Serine/threonine-protein phosphatase 4 catalytic subunit	307	35080	4.91	0	Cytoplasm;Cell membrane;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.	Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.	Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.	Processing of DNA double-strand break ends	PE1	16
+NX_P60520	Gamma-aminobutyric acid receptor-associated protein-like 2	117	13667	7.81	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Autophagosome;Cytosol;Nucleus	NA	Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.	The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes.;The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.	Belongs to the ATG8 family.	Regulation of autophagy;GABAergic synapse;Macroautophagy;TBC/RABGAPs	PE1	16
+NX_P60568	Interleukin-2	153	17628	7.67	0	Secreted	NA	Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.	NA	Belongs to the IL-2 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;T cell receptor signaling pathway;Intestinal immune network for IgA production;Type I diabetes mellitus;Chagas disease (American trypanosomiasis);Measles;HTLV-I infection;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;RAF/MAP kinase cascade;Interleukin receptor SHC signaling;RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs);Interleukin-2 signaling	PE1	4
+NX_P60602	Reactive oxygen species modulator 1	79	8183	9.58	1	Cytoplasm;Mitochondrion inner membrane	NA	Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.;Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.	NA	Belongs to the MGR2 family.	NA	PE1	20
+NX_P60604	Ubiquitin-conjugating enzyme E2 G2	165	18566	4.62	0	NA	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).	NA	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Parkinson's disease;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	21
+NX_P60606	Cortexin-1	82	9045	5.08	1	Membrane;Nucleoplasm;Cell junction;Cell membrane	NA	May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.	NA	Belongs to the cortexin family.	NA	PE2	19
+NX_P60608	Endogenous retrovirus group FC1 member 1 Env polyprotein	527	58319	8.65	0	Virion	NA	Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.	The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane domain (By similarity).	Belongs to the gamma type-C retroviral envelope protein family. HERV class-I F(c)2 env subfamily.	NA	PE1	7
+NX_P60660	Myosin light polypeptide 6	151	16930	4.56	0	NA	NA	Regulatory light chain of myosin. Does not bind calcium.	NA	NA	Vascular smooth muscle contraction;EPHA-mediated growth cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate CIT;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs	PE1	12
+NX_P60673	Profilin-3	137	14596	9.49	0	Nucleus;Cytoskeleton	NA	Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis.	NA	Belongs to the profilin family.	Regulation of actin cytoskeleton;Shigellosis;Salmonella infection	PE1	5
+NX_P60709	Actin, cytoplasmic 1	375	41737	5.29	0	Nucleus;Cytoskeleton	Baraitser-Winter syndrome 1;Dystonia, juvenile-onset	Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947).	Actin, cytoplasmic 1, N-terminally processed: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins (PubMed:29581253). In contrast, filament nucleation by the Arp2/3 complex is not affected (PubMed:29581253).;Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.;ISGylated.;Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes (PubMed:23673617). Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617).;Methylated at His-73 by SETD3 (PubMed:30526847, PubMed:30626964, PubMed:30785395). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity).;(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).	Belongs to the actin family.	Phagosome;Focal adhesion;Adherens junction;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Gastric acid secretion;Bacterial invasion of epithelial cells;Vibrio cholerae infection;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Influenza A;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Viral myocarditis;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Factors involved in megakaryocyte development and platelet production;HATs acetylate histones;RHO GTPases Activate Formins;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;VEGFA-VEGFR2 Pathway;Prefoldin mediated transfer of substrate to CCT/TriC;Folding of actin by CCT/TriC;Interaction between L1 and Ankyrins;Recycling pathway of L1;MAP2K and MAPK activation;Adherens junctions interactions;Gap junction degradation;RHO GTPases activate IQGAPs;Formation of annular gap junctions;Cell-extracellular matrix interactions;DNA Damage Recognition in GG-NER;B-WICH complex positively regulates rRNA expression;UCH proteinases;Clathrin-mediated endocytosis;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	7
+NX_P60763	Ras-related C3 botulinum toxin substrate 3	192	21379	8.43	0	Cytoplasm;Cell membrane;Endomembrane system;Lamellipodium;Perinuclear region;Cytoskeleton	NA	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.	(Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.	Belongs to the small GTPase superfamily. Rho family.	MAPK signaling pathway;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Focal adhesion;Adherens junction;Natural killer cell mediated cytotoxicity;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Viral myocarditis;Rho GTPase cycle;PCP/CE pathway	PE1	17
+NX_P60827	Complement C1q tumor necrosis factor-related protein 8	252	27685	9.7	0	Secreted	NA	May play a role as ligand of RXFP1.	Not N-glycosylated.	NA	NA	PE1	16
+NX_P60842	Eukaryotic initiation factor 4A-I	406	46154	5.32	0	Cytoplasm;Nucleus	NA	ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	NA	Belongs to the DEAD box helicase family. eIF4A subfamily.	RNA transport;ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Deadenylation of mRNA;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	PE1	17
+NX_P60852	Zona pellucida sperm-binding protein 1	638	70049	6.63	1	Extracellular matrix;Cell membrane	Oocyte maturation defect 1	Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.	Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.;O-glycosylated.	Belongs to the ZP domain family. ZPB subfamily.	Interaction With Cumulus Cells And The Zona Pellucida	PE1	11
+NX_P60866	40S ribosomal protein S20	119	13373	9.95	0	Endoplasmic reticulum;Cytoplasm;Cytosol	NA	NA	Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).	Belongs to the universal ribosomal protein uS10 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	8
+NX_P60880	Synaptosomal-associated protein 25	206	23315	4.66	0	Cell membrane;Photoreceptor inner segment;Synaptosome;Cytoplasmic vesicle;Cytosol;Perinuclear region	Myasthenic syndrome, congenital, 18	T-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.	(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type E (BoNT/E) which hydrolyzes the 180-Arg-|-Ile-181 bond and inhibits neurotransmitter release (PubMed:9886085).;(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type C (BoNT/C) which hydrolyzes the 198-Arg-|-Ala-199 bond and inhibits neurotransmitter release (PubMed:9886085, PubMed:17718519). C.botulinum type C only rarely infects humans.;Palmitoylated (PubMed:28757145). Cys-85 appears to be the main site, and palmitoylation is required for membrane association (By similarity).;(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type A (BoNT/A, botA) which hydrolyzes the 197-Gln-|-Arg-198 bond and inhibits neurotransmitter release (PubMed:15592454, PubMed:9886085).	Belongs to the SNAP-25 family.	SNARE interactions in vesicular transport;Synaptic vesicle cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Regulation of insulin secretion;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Toxicity of botulinum toxin type A (BoNT/A);Toxicity of botulinum toxin type C (BoNT/C);Toxicity of botulinum toxin type E (BoNT/E);Neutrophil degranulation;Other interleukin signaling	PE1	20
+NX_P60891	Ribose-phosphate pyrophosphokinase 1	318	34834	6.51	0	NA	ARTS syndrome;Phosphoribosylpyrophosphate synthetase superactivity;Charcot-Marie-Tooth disease, X-linked recessive, 5;Deafness, X-linked, 1	Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.	NA	Belongs to the ribose-phosphate pyrophosphokinase family.	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.;Pentose phosphate pathway;Purine metabolism;Metabolic pathways;5-Phosphoribose 1-diphosphate biosynthesis	PE1	X
+NX_P60893	Probable G-protein coupled receptor 85	370	41995	9.75	7	Endoplasmic reticulum;Golgi apparatus;Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	7
+NX_P60896	26S proteasome complex subunit SEM1	70	8278	3.81	0	Cytoplasm;Cytosol;Nucleus	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.	NA	Belongs to the DSS1/SEM1 family.	Proteasome;Homologous recombination;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	7
+NX_P60900	Proteasome subunit alpha type-6	246	27399	6.35	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).	NA	Belongs to the peptidase T1A family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	14
+NX_P60903	Protein S100-A10	97	11203	6.82	0	Cytoplasm;Mitochondrion	NA	Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.	NA	Belongs to the S-100 family.	Dissolution of Fibrin Clot	PE1	1
+NX_P60953	Cell division control protein 42 homolog	191	21259	6.16	0	Cell membrane;Centrosome;Spindle;Dendrite;Midbody;Cytoskeleton	Takenouchi-Kosaki syndrome	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (PubMed:15642749). Regulates cell migration (PubMed:17038317). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (PubMed:14978216). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (PubMed:26465210).	(Microbial infection) AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.;Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor RhoGDI.;(Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of CDC42 and leads to actin disassembly.;CDC42 is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.	MAPK signaling pathway;Chemokine signaling pathway;Endocytosis;Axon guidance;VEGF signaling pathway;Focal adhesion;Adherens junction;Tight junction;T cell receptor signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Regulation of actin cytoskeleton;GnRH signaling pathway;Bacterial invasion of epithelial cells;Epithelial cell signaling in Helicobacter pylori infection;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Pathways in cancer;Renal cell carcinoma;Pancreatic cancer;MAPK6/MAPK4 signaling;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;Factors involved in megakaryocyte development and platelet production;RHO GTPases Activate Formins;GPVI-mediated activation cascade;EPHB-mediated forward signaling;Rho GTPase cycle;VEGFA-VEGFR2 Pathway;EGFR downregulation;CD28 dependent Vav1 pathway;DCC mediated attractive signaling;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases activate KTN1;Inactivation of CDC42 and RAC1;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Myogenesis;G beta:gamma signalling through CDC42	PE1	1
+NX_P60981	Destrin	165	18506	8.06	0	NA	NA	Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.	ISGylated.	Belongs to the actin-binding proteins ADF family.	NA	PE1	20
+NX_P60983	Glia maturation factor beta	142	16713	5.19	0	NA	NA	This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.	Phosphorylated; stimulated by phorbol ester.	Belongs to the actin-binding proteins ADF family. GMF subfamily.	NA	PE1	14
+NX_P60985	Keratinocyte differentiation-associated protein	99	11050	6.72	0	Secreted	NA	May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.	NA	NA	NA	PE1	19
+NX_P61006	Ras-related protein Rab-8A	207	23668	9.15	0	Cytoplasm;Golgi apparatus;Cell membrane;Centriole;Phagosome membrane;Cilium;Cilium basal body;Nucleoplasm;Phagosome;Cilium axoneme;Recycling endosome membrane;Midbody	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). May be involved in ciliogenesis (PubMed:21844891, PubMed:30398148). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069).	Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.	Belongs to the small GTPase superfamily. Rab family.	Pancreatic secretion;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Translocation of SLC2A4 (GLUT4) to the plasma membrane;VxPx cargo-targeting to cilium;RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs;RAB geranylgeranylation	PE1	19
+NX_P61009	Signal peptidase complex subunit 3	180	20313	8.66	1	Microsome membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.;(Microbial infection) Plays an important role in virion production of flaviviruses such as West Nile virus, Japanese enchephalitis virus, Dengue virus type 2 and Yellow Fever virus.	NA	Belongs to the SPCS3 family.	Protein export;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);SRP-dependent cotranslational protein targeting to membrane;Synthesis, secretion, and deacylation of Ghrelin	PE1	4
+NX_P61011	Signal recognition particle 54 kDa protein	504	55705	8.87	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleolus	NA	Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).	NA	Belongs to the GTP-binding SRP family. SRP54 subfamily.	Protein export;SRP-dependent cotranslational protein targeting to membrane	PE1	14
+NX_P61018	Ras-related protein Rab-4B	213	23587	5.8	0	Cell membrane	NA	Protein transport. Probably involved in vesicular traffic (By similarity).	NA	Belongs to the small GTPase superfamily. Rab family.	Neutrophil degranulation;MET receptor recycling;RAB geranylgeranylation	PE1	19
+NX_P61019	Ras-related protein Rab-2A	212	23546	6.08	0	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane;Melanosome;Golgi apparatus membrane	NA	Required for protein transport from the endoplasmic reticulum to the Golgi complex.	NA	Belongs to the small GTPase superfamily. Rab family.	Golgi Cisternae Pericentriolar Stack Reorganization;RAB geranylgeranylation	PE1	8
+NX_P61020	Ras-related protein Rab-5B	215	23707	8.29	0	Cytoplasm;Cell membrane;Melanosome;Early endosome membrane;Cytoplasmic vesicle;Nucleus	NA	Protein transport. Probably involved in vesicular traffic (By similarity).	Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.	Belongs to the small GTPase superfamily. Rab family.	Endocytosis;Phagosome;Vasopressin-regulated water reabsorption;Amoebiasis;Tuberculosis;Clathrin-mediated endocytosis;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs;RAB geranylgeranylation	PE1	12
+NX_P61024	Cyclin-dependent kinases regulatory subunit 1	79	9660	8.89	0	NA	NA	Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	NA	Belongs to the CKS family.	Pathways in cancer;Small cell lung cancer;SCF(Skp2)-mediated degradation of p27/p21;Cyclin D associated events in G1	PE1	1
+NX_P61026	Ras-related protein Rab-10	200	22541	8.58	0	Endoplasmic reticulum membrane;Endosome membrane;Phagosome membrane;trans-Golgi network membrane;Cilium basal body;Cytoplasmic vesicle membrane;Recycling endosome membrane;Golgi apparatus membrane;Perinuclear region	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Plays also a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148).	Phosphorylation of Thr-73 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.	Belongs to the small GTPase superfamily. Rab family.	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	2
+NX_P61073	C-X-C chemokine receptor type 4	352	39746	8.46	7	Cell membrane;Early endosome;Cell junction;Late endosome;Lysosome	WHIM syndrome	(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:8849450, PubMed:8929542, PubMed:9427609, PubMed:10074122, PubMed:10756055).;Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. During wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).	Sulfation on Tyr-21 is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization. Tyr-7 and Tyr-12 are sulfated in a sequential manner after Tyr-21 is almost fully sulfated, with the binding affinity for CXCL12/SDF-1alpha increasing with the number of sulfotyrosines present. Sulfotyrosines Tyr-7 and Tyr-12 occupy clefts on opposing CXCL12 subunits, thus bridging the CXCL12 dimer interface and promoting CXCL12 dimerization.;O- and N-glycosylated. Asn-11 is the principal site of N-glycosylation. There appears to be very little or no glycosylation on Asn-176. N-glycosylation masks coreceptor function in both X4 and R5 laboratory-adapted and primary HIV-1 strains through inhibiting interaction with their Env glycoproteins. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.;Ubiquitinated after ligand binding, leading to its degradation (PubMed:28978524). Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S.;Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation.	Belongs to the G-protein coupled receptor 1 family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Endocytosis;Axon guidance;Leukocyte transendothelial migration;Intestinal immune network for IgA production;G alpha (i) signalling events;Chemokine receptors bind chemokines;Signaling by ROBO receptors;Binding and entry of HIV virion	PE1	2
+NX_P61077	Ubiquitin-conjugating enzyme E2 D3	147	16687	7.67	0	Endosome membrane;Cell membrane	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.	Phosphorylated by AURKB.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Antigen processing: Ubiquitination &amp; Proteasome degradation;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Signaling by BMP;Negative regulators of DDX58/IFIH1 signaling;IKK complex recruitment mediated by RIP1;E3 ubiquitin ligases ubiquitinate target proteins;Neddylation;TICAM1, RIP1-mediated IKK complex recruitment;Peroxisomal protein import	PE1	4
+NX_P61081	NEDD8-conjugating enzyme Ubc12	183	20900	7.57	0	Nucleoplasm;Cytosol;Nucleus	NA	Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.	The acetylation of Met-1 increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.	Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.	Protein modification; protein neddylation.;Ubiquitin mediated proteolysis;Dectin-1 mediated noncanonical NF-kB signaling;NIK-->noncanonical NF-kB signaling;Antigen processing: Ubiquitination &amp; Proteasome degradation;TGF-beta receptor signaling activates SMADs;Neddylation	PE1	19
+NX_P61086	Ubiquitin-conjugating enzyme E2 K	200	22407	5.33	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.	Sumoylation at Lys-14 impairs catalytic activity.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Negative regulators of DDX58/IFIH1 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	4
+NX_P61088	Ubiquitin-conjugating enzyme E2 N	152	17138	6.13	0	Cytoplasm;Nucleus	NA	The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.	Conjugation to ISG15 impairs formation of the thioester bond with ubiquitin but not interaction with UBE2V2.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Antigen processing: Ubiquitination &amp; Proteasome degradation;ISG15 antiviral mechanism;Downstream TCR signaling;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;G2/M DNA damage checkpoint;IKK complex recruitment mediated by RIP1;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;E3 ubiquitin ligases ubiquitinate target proteins;TICAM1, RIP1-mediated IKK complex recruitment;Interleukin-1 signaling	PE1	12
+NX_P61106	Ras-related protein Rab-14	215	23897	5.85	0	Cytoplasm;Recycling endosome;trans-Golgi network membrane;Phagosome;Golgi apparatus membrane;Early endosome membrane;Cytoplasmic vesicle;Nucleus	NA	Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.	NA	Belongs to the small GTPase superfamily. Rab family.	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Synthesis of PIPs at the plasma membrane;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	9
+NX_P61129	Zinc finger CCCH domain-containing protein 6	1189	131670	7.31	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	NA	NA	PE1	2
+NX_P61158	Actin-related protein 3	418	47371	5.61	0	Cytoplasm;Cell projection;Nucleus;Cytoskeleton	NA	ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563).	NA	Belongs to the actin family. ARP3 subfamily.	Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;EPHB-mediated forward signaling;Clathrin-mediated endocytosis	PE1	2
+NX_P61160	Actin-related protein 2	394	44761	6.29	0	Cytoplasm;Cell projection;Cytosol;Nucleus;Cytoskeleton	NA	ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).	NA	Belongs to the actin family. ARP2 subfamily.	Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;EPHB-mediated forward signaling;Clathrin-mediated endocytosis;Neutrophil degranulation	PE1	2
+NX_P61163	Alpha-centractin	376	42614	6.19	0	Cytoplasm;Cell cortex;Centrosome;Cytoskeleton	NA	Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.	NA	Belongs to the actin family. ARP1 subfamily.	Anchoring of the basal body to the plasma membrane;MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;AURKA Activation by TPX2;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	10
+NX_P61165	Transmembrane protein 258	79	9079	5.57	2	Membrane;Endoplasmic reticulum;Cytosol;Cell membrane	NA	Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:26472760, PubMed:27974209). Involved in ER homeostasis in the colonic epithelium (By similarity).	NA	Belongs to the OST5 family.	Protein modification; protein glycosylation.	PE1	11
+NX_P61201	COP9 signalosome complex subunit 2	443	51597	5.36	0	Cytoplasmic vesicle;Cytoplasm;Nucleus;Cytoskeleton	NA	Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.	Phosphorylated by CK2 and PKD kinases.	Belongs to the CSN2 family.	Formation of TC-NER Pre-Incision Complex;DNA Damage Recognition in GG-NER;Cargo recognition for clathrin-mediated endocytosis;Neddylation	PE1	15
+NX_P61204	ADP-ribosylation factor 3	181	20601	6.84	0	Golgi apparatus;Perinuclear region	NA	GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.	NA	Belongs to the small GTPase superfamily. Arf family.	Synthesis of PIPs at the Golgi membrane;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	12
+NX_P61218	DNA-directed RNA polymerases I, II, and III subunit RPABC2	127	14478	4.11	0	Nucleoplasm;Nucleus;Nucleolus	NA	DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).	NA	Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Huntington's disease;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Cytosolic sensors of pathogen-associated DNA;MicroRNA (miRNA) biogenesis;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	22
+NX_P61221	ATP-binding cassette sub-family E member 1	599	67314	8.63	0	Cytoplasm;Cytosol;Mitochondrion	NA	Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.	NA	Belongs to the ABC transporter superfamily. ABCE family.	Interferon alpha/beta signaling;OAS antiviral response	PE1	4
+NX_P61224	Ras-related protein Rap-1b	184	20825	5.65	0	Cytoplasm;Cell membrane;Cell junction;Cytosol;Nucleus	NA	GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.	NA	Belongs to the small GTPase superfamily. Ras family.	MAPK signaling pathway;Chemokine signaling pathway;Focal adhesion;Leukocyte transendothelial migration;Long-term potentiation;Neurotrophin signaling pathway;Pancreatic secretion;Renal cell carcinoma;MAP2K and MAPK activation;Integrin alphaIIb beta3 signaling;Rap1 signalling;GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;Neutrophil degranulation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates RAP1 and RAC1;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	12
+NX_P61225	Ras-related protein Rap-2b	183	20504	4.73	0	Recycling endosome membrane	NA	Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.	Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK.	Belongs to the small GTPase superfamily. Ras family.	Neutrophil degranulation	PE1	3
+NX_P61236	Protein yippee-like 3	119	13608	7.66	0	Nucleolus	NA	Involved in proliferation and apoptosis in myeloid precursor cells.	Probably ubiquitinated leading to its degradation by the proteasome.	Belongs to the yippee family.	NA	PE1	16
+NX_P61244	Protein max	160	18275	5.88	0	Golgi apparatus;Nucleoplasm;Cytoplasmic vesicle;Dendrite;Nucleus	Pheochromocytoma	Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.	Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.;MAX is phosphorylated by MAPK14 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the MAX family.	MAPK signaling pathway;Pathways in cancer;Small cell lung cancer;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry;Transcription of E2F targets under negative control by DREAM complex;Transcriptional Regulation by E2F6	PE1	14
+NX_P61247	40S ribosomal protein S3a	264	29945	9.75	0	Cytoplasm;Nucleolus;Endoplasmic reticulum;Cytosol;Nucleus	NA	May play a role during erythropoiesis through regulation of transcription factor DDIT3.	NA	Belongs to the eukaryotic ribosomal protein eS1 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	4
+NX_P61254	60S ribosomal protein L26	145	17258	10.55	0	NA	Diamond-Blackfan anemia 11	Component of the large ribosomal subunit.	NA	Belongs to the universal ribosomal protein uL24 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	17
+NX_P61266	Syntaxin-1B	288	33245	5.25	1	Membrane;Spindle;Centrosome;Nucleus	Generalized epilepsy with febrile seizures plus 9	Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity).	Phosphorylated by CK2.	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;Synaptic vesicle cycle;LGI-ADAM interactions;Toxicity of botulinum toxin type C (BoNT/C)	PE1	16
+NX_P61278	Somatostatin	116	12736	5.47	0	Secreted	NA	Somatostatin-14: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.;Neuronostatin: May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity). This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476).	C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure.	Belongs to the somatostatin family.	Gastric acid secretion;G alpha (i) signalling events;Peptide ligand-binding receptors;MECP2 regulates transcription of neuronal ligands	PE1	3
+NX_P61289	Proteasome activator complex subunit 3	254	29506	5.69	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).	Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1.;Phosphorylated by MAP3K3 (By similarity). Phosphorylation at Ser-247 promotes its association with CCAR2.	Belongs to the PA28 family.	Proteasome;Antigen processing and presentation;Hepatitis C;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	17
+NX_P61296	Heart- and neural crest derivatives-expressed protein 2	217	23666	9.23	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).	NA	NA	Transcriptional regulation by RUNX2	PE1	4
+NX_P61313	60S ribosomal protein L15	204	24146	11.62	0	Membrane	Diamond-Blackfan anemia 12	NA	NA	Belongs to the eukaryotic ribosomal protein eL15 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	3
+NX_P61326	Protein mago nashi homolog	146	17164	5.74	0	Nucleoplasm;Cytoplasm;Nucleus speckle;Nucleus	NA	Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638). Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.	NA	Belongs to the mago nashi family.	RNA transport;mRNA surveillance pathway;Spliceosome;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Regulation of expression of SLITs and ROBOs;RNA Polymerase II Transcription Termination	PE1	1
+NX_P61328	Fibroblast growth factor 12	243	27399	9.98	0	Nucleoplasm;Cytosol;Nucleus	Epileptic encephalopathy, early infantile, 47	Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;Phase 0 - rapid depolarisation	PE1	3
+NX_P61353	60S ribosomal protein L27	136	15798	10.56	0	Cytoplasm;Cytosol;Nucleolus;Rough endoplasmic reticulum	Diamond-Blackfan anemia 16	Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902).	NA	Belongs to the eukaryotic ribosomal protein eL27 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	17
+NX_P61366	Osteocrin	133	14722	9.62	0	Secreted	NA	Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).	NA	Belongs to the Osteocrin family.	NA	PE1	3
+NX_P61371	Insulin gene enhancer protein ISL-1	349	39036	8.64	0	Nucleoplasm;Nucleus	NA	DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity).	Phosphorylated.	NA	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);Regulation of expression of SLITs and ROBOs	PE1	5
+NX_P61421	V-type proton ATPase subunit d 1	351	40329	4.89	0	Membrane	NA	Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).	NA	Belongs to the V-ATPase V0D/AC39 subunit family.	Oxidative phosphorylation;Metabolic pathways;Lysosome;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Tuberculosis;Rheumatoid arthritis;Transferrin endocytosis and recycling;XBP1(S) activates chaperone genes;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	16
+NX_P61457	Pterin-4-alpha-carbinolamine dehydratase	104	12000	6.28	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	Hyperphenylalaninemia, BH4-deficient, D	Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.	NA	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.	Phenylalanine metabolism	PE1	10
+NX_P61513	60S ribosomal protein L37a	92	10275	10.44	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL43 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	2
+NX_P61550	Endogenous retrovirus group S71 member 1 Env polyprotein	626	68171	8.25	1	Cell membrane	NA	Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.	The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane domain (By similarity).	Belongs to the gamma type-C retroviral envelope protein family. HERV class-I T env subfamily.	NA	PE1	19
+NX_P61565	Endogenous retrovirus group K member 21 Env polyprotein	698	79236	9.22	1	Virion;Cell membrane	NA	SU mediates receptor recognition.;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.;TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.	NA	PE1	12
+NX_P61566	Endogenous retrovirus group K member 24 Env polyprotein	588	66585	8.23	1	Virion;Cell membrane	NA	TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).;SU mediates receptor recognition.;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.	NA	PE2	22
+NX_P61567	Endogenous retrovirus group K member 7 Env polyprotein	588	66649	8.55	1	Virion;Cell membrane	NA	Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.;TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).;SU mediates receptor recognition.	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.	NA	PE2	1
+NX_P61568	Putative endogenous retrovirus group K member 11-1 Env polyprotein	191	21462	6.29	0	Virion	NA	Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity).	NA	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-8) env subfamily.	NA	PE5	1
+NX_P61570	Endogenous retrovirus group K member 25 Env polyprotein	661	74892	9	1	Virion;Cell membrane	NA	Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity).;SU mediates receptor recognition.;TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.	NA	PE3	11
+NX_P61571	Endogenous retrovirus group K member 21 Rec protein	104	11722	10.39	0	Cytoplasm;Nucleolus	NA	Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).	NA	NA	NA	PE1	12
+NX_P61572	Endogenous retrovirus group K member 19 Rec protein	105	11828	10.22	0	Cytoplasm;Nucleolus	NA	Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).	NA	NA	NA	PE1	19
+NX_P61573	Endogenous retrovirus group K member 9 Rec protein	105	11828	10.22	0	Cytoplasm;Nucleolus	NA	Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).	NA	NA	NA	PE1	6
+NX_P61574	Endogenous retrovirus group K member 113 Rec protein	105	11920	10.13	0	Cytoplasm;Nucleolus	NA	Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).	NA	NA	NA	PE1	19
+NX_P61575	Endogenous retrovirus group K member 8 Rec protein	105	11844	10.22	0	Cytoplasm;Nucleolus	NA	Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).	NA	NA	NA	PE1	8
+NX_P61576	Endogenous retrovirus group K member 104 Rec protein	105	11735	9.95	0	Cytoplasm;Nucleolus	NA	Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).	NA	NA	NA	PE1	5
+NX_P61578	Endogenous retrovirus group K member 16 Rec protein	105	11808	10	0	Cytoplasm;Nucleolus	NA	Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).	NA	NA	NA	PE1	10
+NX_P61579	Endogenous retrovirus group K member 25 Rec protein	105	11828	10.22	0	Cytoplasm;Nucleolus	NA	Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).	NA	NA	NA	PE1	11
+NX_P61580	Endogenous retrovirus group K member 10 Np9 protein	75	8892	9.91	0	Nucleus	NA	May possess a function in tumorigenesis.	NA	NA	NA	PE1	5
+NX_P61581	Endogenous retrovirus group K member 24 Np9 protein	75	8893	9.74	0	Nucleus	NA	May possess a function in tumorigenesis.	NA	NA	NA	PE1	22
+NX_P61582	Endogenous retrovirus group K member 7 Np9 protein	75	8820	9.58	0	Nucleus	NA	May possess a function in tumorigenesis.	NA	NA	NA	PE3	1
+NX_P61583	Endogenous retrovirus group K member 5 Np9 protein	75	8907	9.66	0	Nucleus	NA	May possess a function in tumorigenesis.	NA	NA	NA	PE3	3
+NX_P61586	Transforming protein RhoA	193	21768	5.83	0	Cell cortex;Cleavage furrow;Cell membrane;Lamellipodium;Cytosol;Dendrite;Midbody;Cytoskeleton	NA	(Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague.;Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:8910519, PubMed:9121475). Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:16236794, PubMed:12900402). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:20974804, PubMed:23940119). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695). May be an activator of PLCE1 (PubMed:16103226). In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity).	(Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.;Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling (PubMed:11162591). Phosphorylation by SLK at Ser-188 in response to AGTR2 activation (By similarity).;Ubiquitinated by the BCR(KCTD13) and BCR(TNFAIP1) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and synaptic transmission in neurons.;(Microbial infection) Substrate for botulinum ADP-ribosyltransferase.;(Microbial infection) Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage.;(Microbial infection) AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.	Belongs to the small GTPase superfamily. Rho family.	Chemokine signaling pathway;Endocytosis;Vascular smooth muscle contraction;Wnt signaling pathway;TGF-beta signaling pathway;Axon guidance;Focal adhesion;Adherens junction;Tight junction;T cell receptor signaling pathway;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Regulation of actin cytoskeleton;Pancreatic secretion;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Pertussis;Tuberculosis;Pathways in cancer;Colorectal cancer;RHO GTPases Activate Rhotekin and Rhophilins;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);RHO GTPases Activate Formins;GPVI-mediated activation cascade;G beta:gamma signalling through PI3Kgamma;EPHB-mediated forward signaling;Axonal growth inhibition (RHOA activation);Rho GTPase cycle;Axonal growth stimulation;G alpha (12/13) signalling events;VEGFA-VEGFR2 Pathway;EPHA-mediated growth cone collapse;PCP/CE pathway;Sema4D mediated inhibition of cell attachment and migration;RHO GTPases activate PKNs;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate KTN1;PI3K/AKT activation;ERBB2 Regulates Cell Motility;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;Ovarian tumor domain proteases;Neutrophil degranulation;SLIT2:ROBO1 increases RHOA activity	PE1	3
+NX_P61587	Rho-related GTP-binding protein RhoE	244	27368	8.78	0	Golgi apparatus membrane	NA	Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.	NA	Belongs to the small GTPase superfamily. Rho family.	NA	PE1	2
+NX_P61599	N-alpha-acetyltransferase 20	178	20368	4.98	0	Cytoplasm;Cytosol;Nucleus	NA	Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.	NA	Belongs to the acetyltransferase family. ARD1 subfamily.	NA	PE1	20
+NX_P61601	Neurocalcin-delta	193	22245	5.23	0	NA	NA	May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.	NA	Belongs to the recoverin family.	Activation of Ca-permeable Kainate Receptor	PE1	8
+NX_P61604	10 kDa heat shock protein, mitochondrial	102	10932	8.89	0	Mitochondrion matrix	NA	Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).	NA	Belongs to the GroES chaperonin family.	NA	PE1	2
+NX_P61619	Protein transport protein Sec61 subunit alpha isoform 1	476	52265	8.3	10	Endoplasmic reticulum;Endoplasmic reticulum membrane	Familial juvenile hyperuricemic nephropathy 4	Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).	NA	Belongs to the SecY/SEC61-alpha family.	Protein export;Protein processing in endoplasmic reticulum;Phagosome;Vibrio cholerae infection;ER-Phagosome pathway;SRP-dependent cotranslational protein targeting to membrane	PE1	3
+NX_P61626	Lysozyme C	148	16537	9.38	0	Golgi apparatus;Nucleoplasm;Secreted;Cytoskeleton	Amyloidosis 8	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.	NA	Belongs to the glycosyl hydrolase 22 family.	Salivary secretion;Amyloid fiber formation;Neutrophil degranulation;Antimicrobial peptides	PE1	12
+NX_P61647	Alpha-2,8-sialyltransferase 8F	398	44836	9.19	1	Endoplasmic reticulum;Golgi apparatus membrane	NA	Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).	NA	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Sialic acid metabolism;N-Glycan antennae elongation	PE1	10
+NX_P61758	Prefoldin subunit 3	197	22626	6.64	0	Cytoplasm;Cytosol;Nucleus;Cytoplasmic vesicle	NA	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.	NA	Belongs to the prefoldin subunit alpha family.	Prefoldin mediated transfer of substrate to CCT/TriC	PE1	X
+NX_P61764	Syntaxin-binding protein 1	594	67569	6.5	0	Membrane;Nucleoplasm;Cytosol	Epileptic encephalopathy, early infantile, 4	Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.	STXBP1 is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	Belongs to the STXBP/unc-18/SEC1 family.	Synaptic vesicle cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Regulation of insulin secretion;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Neurexins and neuroligins	PE1	9
+NX_P61769	Beta-2-microglobulin	119	13715	6.06	0	Golgi apparatus;Cell membrane;Secreted;Cell surface;Cytosol	Amyloidosis 8;Immunodeficiency 43	Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).	Glycation of Ile-21 is observed in long-term hemodialysis patients.	Belongs to the beta-2-microglobulin family.	Antigen processing and presentation;ER-Phagosome pathway;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Endosomal/Vacuolar pathway;Interferon gamma signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;DAP12 signaling;Amyloid fiber formation;Nef mediated downregulation of MHC class I complex cell surface expression;DAP12 interactions;Neutrophil degranulation	PE1	15
+NX_P61803	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1	113	12497	6.52	3	Cytosol;Endoplasmic reticulum membrane	NA	Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of the DAD1 protein triggers apoptosis (PubMed:22467853).	NA	Belongs to the DAD/OST2 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;Asparagine N-linked glycosylation	PE1	14
+NX_P61812	Transforming growth factor beta-2 proprotein	414	47748	8.82	0	Extracellular matrix;Secreted	Loeys-Dietz syndrome 4	Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.;Latency-associated peptide: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity).;Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (PubMed:22772371, PubMed:22772368). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).	Transforming growth factor beta-2 proprotein: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-2 inactive.	Belongs to the TGF-beta family.	MAPK signaling pathway;Cytokine-cytokine receptor interaction;Cell cycle;Endocytosis;TGF-beta signaling pathway;Osteoclast differentiation;Leishmaniasis;Chagas disease (American trypanosomiasis);Malaria;Toxoplasmosis;Amoebiasis;Tuberculosis;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Chronic myeloid leukemia;Rheumatoid arthritis;Hypertrophic cardiomyopathy (HCM);Platelet degranulation;ECM proteoglycans;Molecules associated with elastic fibres	PE1	1
+NX_P61916	NPC intracellular cholesterol transporter 2	151	16570	7.57	0	Endoplasmic reticulum;Secreted;Lysosome	Niemann-Pick disease C2	Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:17018531, PubMed:11125141, PubMed:18772377, PubMed:29580834, PubMed:15937921). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).	NA	Belongs to the NPC2 family.	Lysosome;Neutrophil degranulation;LDL clearance	PE1	14
+NX_P61923	Coatomer subunit zeta-1	177	20198	4.69	0	Golgi apparatus;Cytoplasm;Cell membrane;COPI-coated vesicle membrane;Golgi apparatus membrane	NA	The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.;The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).	NA	Belongs to the adaptor complexes small subunit family.	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	12
+NX_P61925	cAMP-dependent protein kinase inhibitor alpha	76	7989	4.45	0	NA	NA	Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.	NA	Belongs to the PKI family.	NA	PE1	8
+NX_P61927	60S ribosomal protein L37	97	11078	11.74	0	Cytoplasm;Nucleolus;Nucleus	NA	Binds to the 23S rRNA.	NA	Belongs to the eukaryotic ribosomal protein eL37 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	5
+NX_P61952	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	73	8481	5.47	0	Cytoplasm;Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the G protein gamma family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	7
+NX_P61956	Small ubiquitin-related modifier 2	95	10871	5.32	0	PML body;Nucleus	NA	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).	Cleavage of precursor form by SENP1 or SENP2 is necessary for function.;Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.;Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.	Belongs to the ubiquitin family. SUMO subfamily.	RNA transport;SUMOylation of DNA damage response and repair proteins;Vitamin D (calciferol) metabolism;SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of transcription factors;SUMOylation of chromatin organization proteins;SUMOylation of intracellular receptors;SUMOylation of SUMOylation proteins;SUMOylation of transcription cofactors	PE1	17
+NX_P61960	Ubiquitin-fold modifier 1	85	9118	9.36	0	Cytoplasm;Nucleus	Leukodystrophy, hypomyelinating, 14	Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer (PubMed:15071506, PubMed:20018847, PubMed:29868776). The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847, PubMed:29868776). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes (PubMed:15071506, PubMed:20018847). TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable).	NA	Belongs to the UFM1 family.	NA	PE1	13
+NX_P61962	DDB1- and CUL4-associated factor 7	342	38926	5.27	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	NA	Belongs to the WD repeat DCAF7 family.	Protein modification; protein ubiquitination.;Association of TriC/CCT with target proteins during biosynthesis;Neddylation	PE1	17
+NX_P61964	WD repeat-containing protein 5	334	36588	8.54	0	Nucleoplasm;Nucleus	NA	Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.	NA	Belongs to the WD repeat WDR5/wds family.	PKMTs methylate histone lysines;RMTs methylate histone arginines;HATs acetylate histones;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Neddylation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	9
+NX_P61966	AP-1 complex subunit sigma-1A	158	18733	5.6	0	Golgi apparatus;Clathrin-coated pit;Cytoplasmic vesicle membrane	Mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	NA	Belongs to the adaptor complexes small subunit family.	Lysosome;MHC class II antigen presentation;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Nef mediated downregulation of MHC class I complex cell surface expression	PE1	7
+NX_P61968	LIM domain transcription factor LMO4	165	17994	8.75	0	Nucleoplasm;Midbody ring	NA	Probable transcriptional factor.	NA	NA	NA	PE1	1
+NX_P61970	Nuclear transport factor 2	127	14478	5.1	0	Nucleus outer membrane;Nuclear pore complex;Nucleoplasm;Nucleus inner membrane;Cytosol;Cytoskeleton	NA	Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.	NA	NA	NA	PE1	16
+NX_P61978	Heterogeneous nuclear ribonucleoprotein K	463	50976	5.39	0	Nucleoplasm;Cytoplasm;Podosome	Au-Kline syndrome	One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.	Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination.;O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.;Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions.;Arg-296 and Arg-299 are dimethylated, probably to asymmetric dimethylarginine.	NA	Spliceosome;Herpes simplex infection;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;SUMOylation of RNA binding proteins	PE1	9
+NX_P61981	14-3-3 protein gamma	247	28303	4.8	0	Cytoplasm	Epileptic encephalopathy, early infantile, 56	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.	Phosphorylated by various PKC isozymes.	Belongs to the 14-3-3 family.	Cell cycle;Oocyte meiosis;Neurotrophin signaling pathway;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Translocation of SLC2A4 (GLUT4) to the plasma membrane;TP53 Regulates Metabolic Genes;Activation of BAD and translocation to mitochondria;Recruitment of NuMA to mitotic centrosomes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;RHO GTPases activate PKNs;AURKA Activation by TPX2;Regulation of localization of FOXO transcription factors	PE1	7
+NX_P62068	Ubiquitin carboxyl-terminal hydrolase 46	366	42442	6.39	0	Nucleolus	NA	Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014).	NA	Belongs to the peptidase C19 family. USP12/USP46 subfamily.	NA	PE1	4
+NX_P62070	Ras-related protein R-Ras2	204	23400	5.74	0	Nucleoplasm;Cytosol;Cell membrane	Ovarian cancer	It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.	May be post-translationally modified by both palmitoylation and polyisoprenylation.	Belongs to the small GTPase superfamily. Ras family.	MAPK signaling pathway;Tight junction;Regulation of actin cytoskeleton;HTLV-I infection	PE1	11
+NX_P62072	Mitochondrial import inner membrane translocase subunit Tim10	90	10333	5.89	0	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.	NA	Belongs to the small Tim family.	Mitochondrial protein import	PE1	11
+NX_P62079	Tetraspanin-5	268	30337	4.59	4	Cell membrane	NA	Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44.	NA	Belongs to the tetraspanin (TM4SF) family.	Amyloid fiber formation	PE1	4
+NX_P62081	40S ribosomal protein S7	194	22127	10.09	0	Nucleolus;Endoplasmic reticulum;Centrosome;Cytosol;Nucleus	Diamond-Blackfan anemia 8	Required for rRNA maturation.	Phosphorylated by NEK6.;Ubiquitinated. Deubiquitinated by DESI2, leading to its stabilization.;RPS7 is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the eukaryotic ribosomal protein eS7 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	2
+NX_P62136	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	330	37512	5.94	0	Cytoplasm;Cell membrane;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).;(Microbial infection) Necessary for alphaviruses replication.	Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation.;PPP1CA is phosphorylated by FGR (Phosphotyrosine:PTM-0255)	Belongs to the PPP phosphatase family. PP-1 subfamily.	Oocyte meiosis;Vascular smooth muscle contraction;Focal adhesion;Long-term potentiation;Dopaminergic synapse;Regulation of actin cytoskeleton;Insulin signaling pathway;Herpes simplex infection;Triglyceride catabolism;Circadian Clock;DARPP-32 events;Downregulation of TGF-beta receptor signaling	PE1	11
+NX_P62140	Serine/threonine-protein phosphatase PP1-beta catalytic subunit	327	37187	5.84	0	Cytoplasm;Cell membrane;Nucleolus;Nucleoplasm;Cytosol;Nucleus	Noonan syndrome-like disorder with loose anagen hair 2	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).	PPP1CB is phosphorylated by CDC42BPA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the PPP phosphatase family. PP-1 subfamily.	Oocyte meiosis;Vascular smooth muscle contraction;Focal adhesion;Long-term potentiation;Dopaminergic synapse;Regulation of actin cytoskeleton;Insulin signaling pathway;Herpes simplex infection;Regulation of PLK1 Activity at G2/M Transition;Triglyceride catabolism;Circadian Clock;Downregulation of TGF-beta receptor signaling;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs	PE1	2
+NX_P62166	Neuronal calcium sensor 1	190	21879	4.71	0	Golgi apparatus;Cytoplasm;Cell membrane;Membrane;Postsynaptic density;Perinuclear region	NA	Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).	NA	Belongs to the recoverin family.	NA	PE1	9
+NX_P62191	26S proteasome regulatory subunit 4	440	49185	5.87	0	Cytoplasm;Membrane;Nucleoplasm;Cytosol;Nucleus	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.	NA	Belongs to the AAA ATPase family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	14
+NX_P62195	26S proteasome regulatory subunit 8	406	45626	7.11	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.	NA	Belongs to the AAA ATPase family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	17
+NX_P62241	40S ribosomal protein S8	208	24205	10.32	0	Cytoplasm;Nucleolus;Membrane;Endoplasmic reticulum;Cytosol;Nucleus	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eS8 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	1
+NX_P62244	40S ribosomal protein S15a	130	14840	10.14	0	Cytoplasm	Diamond-Blackfan anemia 20	Structural component of the ribosome (PubMed:23636399). Required for proper erythropoiesis (PubMed:27909223).	NA	Belongs to the universal ribosomal protein uS8 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	16
+NX_P62249	40S ribosomal protein S16	146	16445	10.21	0	Endoplasmic reticulum;Cytosol;Cytoplasm	NA	NA	NA	Belongs to the universal ribosomal protein uS9 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_P62253	Ubiquitin-conjugating enzyme E2 G1	170	19509	5.2	0	Nucleoplasm;Cytosol	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.	Autoubiquitinated in vitro.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Parkinson's disease;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	17
+NX_P62256	Ubiquitin-conjugating enzyme E2 H	183	20655	4.55	0	Mitochondrion	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:8132613, PubMed:17588522, PubMed:20061386). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613).	Autoubiquitinated in vitro in the presence of NEDD4L.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	7
+NX_P62258	14-3-3 protein epsilon	255	29174	4.63	0	Cytoplasm;Melanosome;Nucleus	NA	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).	NA	Belongs to the 14-3-3 family.	Cell cycle;Oocyte meiosis;Neurotrophin signaling pathway;Regulation of HSF1-mediated heat shock response;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Signaling by Hippo;TP53 Regulates Metabolic Genes;Activation of BAD and translocation to mitochondria;HSF1 activation;Recruitment of NuMA to mitotic centrosomes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;RHO GTPases activate PKNs;NADE modulates death signalling;AURKA Activation by TPX2;RAB GEFs exchange GTP for GDP on RABs;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	PE1	17
+NX_P62263	40S ribosomal protein S14	151	16273	10.07	0	Endoplasmic reticulum;Cytosol	NA	NA	NA	Belongs to the universal ribosomal protein uS11 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	5
+NX_P62266	40S ribosomal protein S23	143	15808	10.5	0	Endoplasmic reticulum;Cytoplasm;Cytosol;Rough endoplasmic reticulum	Brachycephaly, trichomegaly, and developmental delay	Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28257692, PubMed:23636399, PubMed:25957688, PubMed:25901680). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25957688, PubMed:25901680). Plays an important role in translational accuracy (PubMed:28257692).	Hydroxylation at Pro-62 affects translation termination efficiency.	Belongs to the universal ribosomal protein uS12 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	5
+NX_P62269	40S ribosomal protein S18	152	17719	10.99	0	Cytoplasm;Cytosol	NA	Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.	NA	Belongs to the universal ribosomal protein uS13 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	6
+NX_P62273	40S ribosomal protein S29	56	6677	10.16	0	Endoplasmic reticulum;Cytosol;Cytoplasm;Rough endoplasmic reticulum	Diamond-Blackfan anemia 13	NA	NA	Belongs to the universal ribosomal protein uS14 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	14
+NX_P62277	40S ribosomal protein S13	151	17222	10.53	0	Endoplasmic reticulum;Nucleolus	NA	NA	NA	Belongs to the universal ribosomal protein uS15 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	11
+NX_P62280	40S ribosomal protein S11	158	18431	10.31	0	Endoplasmic reticulum;Cytosol;Nucleolus	NA	NA	Citrullinated by PADI4.	Belongs to the universal ribosomal protein uS17 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_P62304	Small nuclear ribonucleoprotein E	92	10804	9.46	0	Cytosol;Nucleus	Hypotrichosis 11	Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:23246290, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). May indirectly play a role in hair development (PubMed:23246290).	NA	Belongs to the snRNP Sm proteins family.	Spliceosome;snRNP Assembly;SLBP independent Processing of Histone Pre-mRNAs;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	1
+NX_P62306	Small nuclear ribonucleoprotein F	86	9725	4.7	0	Nucleus;Nucleolus;Cytosol	NA	Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319).	NA	Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.	Spliceosome;snRNP Assembly;SLBP independent Processing of Histone Pre-mRNAs;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	12
+NX_P62308	Small nuclear ribonucleoprotein G	76	8496	8.98	0	Cytosol;Nucleus	NA	Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319).	NA	Belongs to the snRNP Sm proteins family.	Spliceosome;snRNP Assembly;SLBP independent Processing of Histone Pre-mRNAs;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	2
+NX_P62310	U6 snRNA-associated Sm-like protein LSm3	102	11845	4.58	0	Nucleoplasm;Nucleolus;Nucleus	NA	Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).	NA	Belongs to the snRNP Sm proteins family.	RNA degradation;Spliceosome;mRNA Splicing - Major Pathway;mRNA decay by 5' to 3' exoribonuclease	PE1	3
+NX_P62312	U6 snRNA-associated Sm-like protein LSm6	80	9128	9.61	0	Cytoplasm;Nucleus;Cytoskeleton	NA	Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway (Probable).	NA	Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.	RNA degradation;Spliceosome;mRNA Splicing - Major Pathway;mRNA decay by 5' to 3' exoribonuclease	PE1	4
+NX_P62314	Small nuclear ribonucleoprotein Sm D1	119	13282	11.56	0	Cytosol;Nucleus	NA	Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (Probable).	Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.	Belongs to the snRNP core protein family.	Spliceosome;Systemic lupus erythematosus;snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	18
+NX_P62316	Small nuclear ribonucleoprotein Sm D2	118	13527	9.92	0	Cytosol;Nucleus	NA	Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077).	NA	Belongs to the snRNP core protein family.	Spliceosome;snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	19
+NX_P62318	Small nuclear ribonucleoprotein Sm D3	126	13916	10.33	0	Nucleoplasm;Cytosol;Nucleus	NA	Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).	Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.	Belongs to the snRNP core protein family.	Spliceosome;Systemic lupus erythematosus;snRNP Assembly;SLBP independent Processing of Histone Pre-mRNAs;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	22
+NX_P62324	Protein BTG1	171	19209	8.35	0	Nucleoplasm;Cytosol	NA	Anti-proliferative protein.	NA	Belongs to the BTG family.	RNA degradation;FOXO-mediated transcription of cell cycle genes	PE1	12
+NX_P62328	Thymosin beta-4	44	5053	5.02	0	Cytoplasmic vesicle;Nucleoplasm;Cytosol;Cytoskeleton	NA	Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.;Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.	NA	Belongs to the thymosin beta family.	Regulation of actin cytoskeleton;Platelet degranulation	PE1	X
+NX_P62330	ADP-ribosylation factor 6	175	20082	9.04	0	Filopodium membrane;Cleavage furrow;Endosome membrane;Cell membrane;trans-Golgi network membrane;Early endosome membrane;Recycling endosome membrane;Ruffle;Cytosol;Midbody ring	NA	(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.;GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:21170023, PubMed:16737952, PubMed:7589240, PubMed:18400762). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity).	NA	Belongs to the small GTPase superfamily. Arf family.	Endocytosis;Fc gamma R-mediated phagocytosis;Clathrin-mediated endocytosis;MET receptor recycling;TBC/RABGAPs	PE1	14
+NX_P62333	26S proteasome regulatory subunit 10B	389	44173	7.09	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.	NA	Belongs to the AAA ATPase family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	14
+NX_P62341	Thioredoxin reductase-like selenoprotein T	195	22324	8.79	1	Endoplasmic reticulum membrane	NA	Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).	May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity).	Belongs to the SelWTH family. Selenoprotein T subfamily.	NA	PE1	3
+NX_P62380	TATA box-binding protein-like protein 1	186	20887	9.61	0	Nucleus;Cytoplasm;Nucleoplasm;Nucleolus	NA	Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.	NA	Belongs to the TBP family.	Basal transcription factors;Huntington's disease;HTLV-I infection;Herpes simplex infection	PE1	6
+NX_P62424	60S ribosomal protein L7a	266	29996	10.61	0	Cytoplasmic vesicle;Nucleolus	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL8 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	9
+NX_P62487	DNA-directed RNA polymerase II subunit RPB7	172	19294	5.33	0	Nucleoplasm;Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.	NA	Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Huntington's disease;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;MicroRNA (miRNA) biogenesis;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	11
+NX_P62491	Ras-related protein Rab-11A	216	24394	6.12	0	Golgi apparatus;Cleavage furrow;Cell membrane;Centriolar satellite;Cytoplasmic vesicle membrane;Recycling endosome membrane;Phagosome;Cytoplasmic vesicle	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.	NA	Belongs to the small GTPase superfamily. Rab family.	Endocytosis;Endocrine and other factor-regulated calcium reabsorption;Vasopressin-regulated water reabsorption;Pancreatic secretion;Anchoring of the basal body to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;VxPx cargo-targeting to cilium;Vasopressin regulates renal water homeostasis via Aquaporins;TBC/RABGAPs;RAB geranylgeranylation	PE1	15
+NX_P62495	Eukaryotic peptide chain release factor subunit 1	437	49031	5.51	0	Cytoplasm	NA	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (PubMed:7990965, PubMed:24486019). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).	Methylated at Gln-185 by N6AMT1.;Hydroxylation at Lys-63 by JMJD4 promotes its translational termination efficiency.	Belongs to the eukaryotic release factor 1 family.	mRNA surveillance pathway;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs	PE1	5
+NX_P62502	Epididymal-specific lipocalin-6	163	18045	4.84	0	Secreted	NA	May play a role in male fertility.	NA	Belongs to the calycin superfamily. Lipocalin family.	NA	PE1	9
+NX_P62508	Estrogen-related receptor gamma	458	51306	6.04	0	Nucleoplasm;Nucleus	NA	Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.	Acetylated by PCAF/KAT2 (in vitro).;Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.;Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.	Belongs to the nuclear hormone receptor family. NR3 subfamily.	Nuclear Receptor transcription pathway	PE1	1
+NX_P62633	Cellular nucleic acid-binding protein	177	19463	8	0	Endoplasmic reticulum;Nucleoplasm;Cytosol;Cytoplasm	Dystrophia myotonica 2	Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.	Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.	NA	NA	PE1	3
+NX_P62683	Endogenous retrovirus group K member 21 Gag polyprotein	666	74000	8.86	0	Cell membrane	NA	The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).;Specific enzymatic cleavages may yield mature proteins.	Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.	NA	PE1	12
+NX_P62684	Endogenous retrovirus group K member 113 Gag polyprotein	666	74038	8.95	0	Cell membrane	NA	The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	Specific enzymatic cleavages may yield mature proteins.;Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).	Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.	NA	PE1	19
+NX_P62685	Endogenous retrovirus group K member 8 Gag polyprotein	647	72181	8.88	0	Cell membrane	NA	The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	Specific enzymatic cleavages may yield mature proteins.;Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).	Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.	NA	PE1	8
+NX_P62699	Protein yippee-like 5	121	13842	6.82	0	Nucleus;Nucleoplasm;Spindle pole;Centrosome;Cytosol;Midbody	NA	Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for normal cell proliferation (By similarity).	NA	Belongs to the yippee family.	Neutrophil degranulation	PE1	2
+NX_P62701	40S ribosomal protein S4, X isoform	263	29598	10.16	0	Cytoplasm;Nucleus;Nucleolus	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eS4 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	X
+NX_P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	309	35575	5.21	0	Cytoplasm;Nucleoplasm;Spindle pole;Centromere;Nucleus	NA	PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.	Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.;May be monoubiquitinated by NOSIP.;Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.	Belongs to the PPP phosphatase family. PP-1 subfamily.	mRNA surveillance pathway;Oocyte meiosis;Wnt signaling pathway;TGF-beta signaling pathway;Tight junction;Dopaminergic synapse;Long-term depression;Chagas disease (American trypanosomiasis);Hepatitis C;Degradation of beta-catenin by the destruction complex;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Negative regulation of MAPK pathway;Cyclin A/B1/B2 associated events during G2/M transition;MASTL Facilitates Mitotic Progression;RAF activation;DARPP-32 events;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Cyclin D associated events in G1;CTLA4 inhibitory signaling;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Spry regulation of FGF signaling;Platelet sensitization by LDL;ERK/MAPK targets;Integration of energy metabolism;PP2A-mediated dephosphorylation of key metabolic factors;ERKs are inactivated;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Regulation of TP53 Degradation;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	8
+NX_P62736	Actin, aortic smooth muscle	377	42009	5.24	0	Cytoskeleton	Aortic aneurysm, familial thoracic 6;Multisystemic smooth muscle dysfunction syndrome;Moyamoya disease 5	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Methylated at His-75 by SETD3.;(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).;Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.;Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.	Belongs to the actin family.	Vascular smooth muscle contraction;Smooth Muscle Contraction;NOTCH4 Intracellular Domain Regulates Transcription	PE1	10
+NX_P62745	Rho-related GTP-binding protein RhoB	196	22123	5.1	0	Nucleus;Cleavage furrow;Late endosome membrane;Cell membrane	NA	Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.	(Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.;Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.	Belongs to the small GTPase superfamily. Rho family.	RHO GTPases Activate Rhotekin and Rhophilins;RHO GTPases Activate Formins;GPVI-mediated activation cascade;Rho GTPase cycle;G alpha (12/13) signalling events;RHO GTPases activate PKNs;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate CIT;RHO GTPases Activate ROCKs	PE1	2
+NX_P62750	60S ribosomal protein L23a	156	17695	10.44	0	Endoplasmic reticulum;Nucleus;Nucleolus;Cytosol	NA	Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195).	Citrullinated by PADI4.;N-terminus is methylated by METTL11A/NTM1.	Belongs to the universal ribosomal protein uL23 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	17
+NX_P62753	40S ribosomal protein S6	249	28681	10.85	0	Endoplasmic reticulum;Nucleolus;Nucleus;Cytosol	NA	May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.	Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.;Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.;RPS6 is phosphorylated by RPS6KB2 (Phosphoserine:PTM-0253)	Belongs to the eukaryotic ribosomal protein eS6 family.	Ribosome;mTOR signaling pathway;Insulin signaling pathway;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;mTORC1-mediated signalling;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	9
+NX_P62760	Visinin-like protein 1	191	22142	5.01	0	NA	NA	Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.	NA	Belongs to the recoverin family.	NA	PE1	2
+NX_P62805	Histone H4	103	11367	11.36	0	Nucleoplasm;Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Sumoylated, which is associated with transcriptional repression.;Butyrylation of histones marks active promoters and competes with histone acetylation.;Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing.;Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.;Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.;Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.;Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).;HIST1H4A is phosphorylated by DAPK3 (Phosphothreonine:PTM-0254)	Belongs to the histone H4 family.	Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Transcriptional regulation by small RNAs;PKMTs methylate histone lysines;RMTs methylate histone arginines;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;HDMs demethylate histones;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;SUMOylation of chromatin organization proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	12
+NX_P62807	Histone H2B type 1-C/E/F/G/I	126	13906	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.;Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.	Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes.;Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.	Belongs to the histone H2B family.	Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_P62820	Ras-related protein Rab-1A	205	22678	5.93	0	Cytoplasm;Golgi apparatus;Early endosome;Membrane;Endoplasmic reticulum;Melanosome;Cytosol	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.	Phosphorylated by CDK1 kinase during mitosis.;Phosphocholinated at Ser-79 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB.	Belongs to the small GTPase superfamily. Rab family.	Legionellosis;Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	2
+NX_P62826	GTP-binding nuclear protein Ran	216	24423	7.01	0	Cytoplasm;Nucleoplasm;Nucleus envelope;Melanosome;Cytosol;Nucleus	NA	GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:8276887, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:26272610). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:7819259, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:29040603, PubMed:11336674, PubMed:26272610). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:8421051, PubMed:12194828, PubMed:29040603). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640).	Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding.	Belongs to the small GTPase superfamily. Ran family.	Ribosome biogenesis in eukaryotes;RNA transport;HTLV-I infection;Rev-mediated nuclear export of HIV RNA;Nuclear import of Rev protein;Transcriptional regulation by small RNAs;MicroRNA (miRNA) biogenesis;Regulation of cholesterol biosynthesis by SREBP (SREBF);NEP/NS2 Interacts with the Cellular Export Machinery;tRNA processing in the nucleus	PE1	12
+NX_P62829	60S ribosomal protein L23	140	14865	10.51	0	Cytoplasm;Cytosol	NA	NA	NA	Belongs to the universal ribosomal protein uL14 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	17
+NX_P62834	Ras-related protein Rap-1A	184	20987	6.39	0	Cytoplasm;Cell membrane;Early endosome;Cell junction;Perinuclear region	NA	Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.	NA	Belongs to the small GTPase superfamily. Ras family.	MAPK signaling pathway;Chemokine signaling pathway;Focal adhesion;Leukocyte transendothelial migration;Long-term potentiation;Neurotrophin signaling pathway;Pancreatic secretion;Renal cell carcinoma;MAP2K and MAPK activation;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;ARMS-mediated activation;Integrin alphaIIb beta3 signaling;Frs2-mediated activation;Rap1 signalling;GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;Neutrophil degranulation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates RAP1 and RAC1	PE1	1
+NX_P62837	Ubiquitin-conjugating enzyme E2 D2	147	16735	7.69	0	NA	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.	NA	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Shigellosis;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Negative regulators of DDX58/IFIH1 signaling;IKK complex recruitment mediated by RIP1;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;Neddylation;TICAM1, RIP1-mediated IKK complex recruitment;Peroxisomal protein import	PE1	5
+NX_P62841	40S ribosomal protein S15	145	17040	10.39	0	Cytoplasm;Nucleolus;Endoplasmic reticulum;Cytosol;Nucleus	NA	NA	NA	Belongs to the universal ribosomal protein uS19 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_P62847	40S ribosomal protein S24	133	15423	10.79	0	Endoplasmic reticulum;Cytosol;Nucleus	Diamond-Blackfan anemia 3	Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.	NA	Belongs to the eukaryotic ribosomal protein eS24 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	10
+NX_P62851	40S ribosomal protein S25	125	13742	10.12	0	Endoplasmic reticulum;Cytoplasm;Cytosol	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eS25 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	11
+NX_P62854	40S ribosomal protein S26	115	13015	11.01	0	Cytoplasm;Cytosol;Rough endoplasmic reticulum	Diamond-Blackfan anemia 10	NA	NA	Belongs to the eukaryotic ribosomal protein eS26 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	12
+NX_P62857	40S ribosomal protein S28	69	7841	10.7	0	Cytoplasm;Cytosol;Rough endoplasmic reticulum	Diamond-Blackfan anemia 15, with mandibulofacial dysostosis	NA	NA	Belongs to the eukaryotic ribosomal protein eS28 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_P62861	40S ribosomal protein S30	59	6648	12.15	0	Endoplasmic reticulum;Nucleolus;Nucleus;Cytosol	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eS30 family.	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	11
+NX_P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	340	37377	5.6	0	NA	Mental retardation, autosomal dominant 42	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.	Belongs to the WD repeat G protein beta family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Taste transduction;Phototransduction;G alpha (i) signalling events;Olfactory Signaling Pathway;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	1
+NX_P62875	DNA-directed RNA polymerases I, II, and III subunit RPABC5	67	7645	7.65	0	Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).	NA	Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Huntington's disease;Viral Messenger RNA Synthesis;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Cytosolic sensors of pathogen-associated DNA;MicroRNA (miRNA) biogenesis;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;TP53 Regulates Transcription of DNA Repair Genes;Estrogen-dependent gene expression	PE1	11
+NX_P62877	E3 ubiquitin-protein ligase RBX1	108	12274	6.49	0	Cytoplasm;Nucleoplasm;Nucleus	NA	E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:10230407, PubMed:10579999, PubMed:15983046, PubMed:16678110, PubMed:19112177, PubMed:19679664, PubMed:23455478, PubMed:27565346, PubMed:29769719, PubMed:11961546, PubMed:22748924). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Recruits the E2 ubiquitin-conjugating enzyme CDC34 to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.	NA	Belongs to the RING-box family.	Protein modification; protein ubiquitination.;Nucleotide excision repair;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Wnt signaling pathway;TGF-beta signaling pathway;Circadian rhythm - mammal;Pathways in cancer;Renal cell carcinoma;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Degradation of DVL;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;Orc1 removal from chromatin;Antigen processing: Ubiquitination &amp; Proteasome degradation;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Prolactin receptor signaling;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Recognition of DNA damage by PCNA-containing replication complex;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;DNA Damage Recognition in GG-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX2 expression and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling	PE1	22
+NX_P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	340	37331	5.6	0	Perinuclear region	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the WD repeat G protein beta family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	7
+NX_P62888	60S ribosomal protein L30	115	12784	9.65	0	Endoplasmic reticulum;Cytoplasm;Cytosol;Nucleolus	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL30 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	8
+NX_P62891	60S ribosomal protein L39	51	6407	12.55	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL39 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	X
+NX_P62899	60S ribosomal protein L31	125	14463	10.54	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL31 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	2
+NX_P62906	60S ribosomal protein L10a	217	24831	9.94	0	Endoplasmic reticulum;Cytosol;Nucleolus	NA	Component of the large ribosomal subunit.	NA	Belongs to the universal ribosomal protein uL1 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	6
+NX_P62910	60S ribosomal protein L32	135	15860	11.32	0	Endoplasmic reticulum;Cytoplasm;Cytosol	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL32 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	3
+NX_P62913	60S ribosomal protein L11	178	20252	9.64	0	Cytoplasm;Nucleolus;Cytoplasmic vesicle	Diamond-Blackfan anemia 7	Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity).	NA	Belongs to the universal ribosomal protein uL5 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	1
+NX_P62917	60S ribosomal protein L8	257	28025	11.04	0	Cytoplasm;Nucleolus;Endoplasmic reticulum;Cytosol;Nucleus	NA	Component of the large ribosomal subunit.	Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia.	Belongs to the universal ribosomal protein uL2 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	8
+NX_P62937	Peptidyl-prolyl cis-trans isomerase A	165	18012	7.68	0	Cytoplasm;Secreted	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.	Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.	Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.	Integration of provirus;Budding and maturation of HIV virion;Platelet degranulation;Basigin interactions;Assembly Of The HIV Virion;APOBEC3G mediated resistance to HIV-1 infection;Binding and entry of HIV virion;Uncoating of the HIV Virion;Early Phase of HIV Life Cycle;Minus-strand DNA synthesis;Plus-strand DNA synthesis;Neutrophil degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Calcineurin activates NFAT	PE1	7
+NX_P62942	Peptidyl-prolyl cis-trans isomerase FKBP1A	108	11951	7.89	0	Cytosol;Sarcoplasmic reticulum membrane	NA	Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.	NA	Belongs to the FKBP-type PPIase family. FKBP1 subfamily.	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling activates SMADs;TGFBR1 LBD Mutants in Cancer;Calcineurin activates NFAT	PE1	20
+NX_P62945	60S ribosomal protein L41	25	3456	12.96	0	Endoplasmic reticulum;Cytoplasm;Nucleus;Nucleolus	NA	Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.	NA	Belongs to the eukaryotic ribosomal protein eL41 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	12
+NX_P62952	Bladder cancer-associated protein	87	9876	6.21	2	Membrane;Nucleolus	NA	May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.	NA	Belongs to the BLCAP family.	NA	PE1	20
+NX_P62955	Voltage-dependent calcium channel gamma-7 subunit	275	31003	6.65	4	Cell membrane	NA	Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2 (PubMed:21172611).	NA	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	19
+NX_P62979	Ubiquitin-40S ribosomal protein S27a	156	17965	9.68	0	Cytoplasm;Nucleolus;Endoplasmic reticulum;Cytosol;Nucleus	NA	40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.;Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.	Ubiquitin: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.;Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).	In the N-terminal section; belongs to the ubiquitin family.;In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.	Ribosome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;ISG15 antiviral mechanism;Translesion Synthesis by POLH;Regulation of PLK1 Activity at G2/M Transition;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);NOD1/2 Signaling Pathway;Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;Stimuli-sensing channels;Senescence-Associated Secretory Phenotype (SASP);Amyloid fiber formation;p75NTR recruits signalling complexes;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Negative regulation of MAPK pathway;Circadian Clock;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;EGFR downregulation;TCF dependent signaling in response to WNT;Iron uptake and transport;APC/C:Cdc20 mediated degradation of Cyclin B;APC-Cdc20 mediated degradation of Nek2A;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;Downregulation of TGF-beta receptor signaling;Deactivation of the beta-catenin transactivating complex;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Oncogene Induced Senescence;Glycogen synthesis;Myoclonic epilepsy of Lafora;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;Regulation of FZD by ubiquitination;Regulation of innate immune responses to cytosolic DNA;ER Quality Control Compartment (ERQC);Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;Activated NOTCH1 Transmits Signal to the Nucleus;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Cyclin D associated events in G1;Regulation of signaling by CBL;ABC-family proteins mediated transport;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Spry regulation of FGF signaling;Downregulation of ERBB4 signaling;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;IRAK2 mediated activation of TAK1 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Recognition of DNA damage by PCNA-containing replication complex;Downregulation of ERBB2:ERBB3 signaling;NF-kB is activated and signals survival;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Assembly Of The HIV Virion;NRIF signals cell death from the nucleus;Regulation of necroptotic cell death;Defective CFTR causes cystic fibrosis;Stabilization of p53;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Pink/Parkin Mediated Mitophagy;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Formation of Incision Complex in GG-NER;Fanconi Anemia Pathway;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;Major pathway of rRNA processing in the nucleolus and cytosol;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Regulation of TP53 Activity through Phosphorylation;Selenocysteine synthesis;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;UCH proteinases;Ub-specific processing proteases;Ovarian tumor domain proteases;Josephin domain DUBs;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Metalloprotease DUBs;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Negative regulation of MET activity;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;TICAM1, RIP1-mediated IKK complex recruitment;Regulation of PTEN localization;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;NOTCH3 Activation and Transmission of Signal to the Nucleus;Peroxisomal protein import;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	2
+NX_P62987	Ubiquitin-60S ribosomal protein L40	128	14728	9.87	0	Cytoplasm;Cell membrane;Endoplasmic reticulum;Nucleoplasm;Cytosol;Nucleus	NA	60S ribosomal protein L40: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.;Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.	Ubiquitin: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.;Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).	In the N-terminal section; belongs to the ubiquitin family.;In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.	Ribosome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;ISG15 antiviral mechanism;Translesion Synthesis by POLH;Regulation of PLK1 Activity at G2/M Transition;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);NOD1/2 Signaling Pathway;Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;Stimuli-sensing channels;Senescence-Associated Secretory Phenotype (SASP);Amyloid fiber formation;p75NTR recruits signalling complexes;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Negative regulation of MAPK pathway;Circadian Clock;L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;EGFR downregulation;TCF dependent signaling in response to WNT;Iron uptake and transport;APC/C:Cdc20 mediated degradation of Cyclin B;APC-Cdc20 mediated degradation of Nek2A;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;Downregulation of TGF-beta receptor signaling;Deactivation of the beta-catenin transactivating complex;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Oncogene Induced Senescence;Glycogen synthesis;Myoclonic epilepsy of Lafora;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK;Regulation of FZD by ubiquitination;Regulation of innate immune responses to cytosolic DNA;ER Quality Control Compartment (ERQC);Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;Activated NOTCH1 Transmits Signal to the Nucleus;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Cyclin D associated events in G1;Regulation of signaling by CBL;ABC-family proteins mediated transport;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Spry regulation of FGF signaling;Downregulation of ERBB4 signaling;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;IRAK2 mediated activation of TAK1 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Recognition of DNA damage by PCNA-containing replication complex;Downregulation of ERBB2:ERBB3 signaling;NF-kB is activated and signals survival;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Assembly Of The HIV Virion;NRIF signals cell death from the nucleus;Regulation of necroptotic cell death;Defective CFTR causes cystic fibrosis;Stabilization of p53;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Pink/Parkin Mediated Mitophagy;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Formation of Incision Complex in GG-NER;Fanconi Anemia Pathway;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;Major pathway of rRNA processing in the nucleolus and cytosol;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Regulation of TP53 Activity through Phosphorylation;Selenocysteine synthesis;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;UCH proteinases;Ub-specific processing proteases;Ovarian tumor domain proteases;Josephin domain DUBs;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Metalloprotease DUBs;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Negative regulation of MET activity;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;TICAM1, RIP1-mediated IKK complex recruitment;Regulation of PTEN localization;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;NOTCH3 Activation and Transmission of Signal to the Nucleus;Peroxisomal protein import;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	19
+NX_P62993	Growth factor receptor-bound protein 2	217	25206	5.89	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Endosome;Nucleus	NA	Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element.;Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.;Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.	NA	Belongs to the GRB2/sem-5/DRK family.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Dorso-ventral axis formation;Osteoclast differentiation;Focal adhesion;Gap junction;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Neurotrophin signaling pathway;Insulin signaling pathway;GnRH signaling pathway;Hepatitis C;Pathways in cancer;Renal cell carcinoma;Endometrial cancer;Glioma;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;RAF/MAP kinase cascade;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;PI3K Cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;Role of LAT2/NTAL/LAB on calcium mobilization;Interleukin receptor SHC signaling;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;EGFR downregulation;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;EGFR Transactivation by Gastrin;Signaling by SCF-KIT;Regulation of KIT signaling;CD28 dependent Vav1 pathway;Signaling by cytosolic FGFR1 fusion mutants;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Interleukin-3, Interleukin-5 and GM-CSF signaling;Signal regulatory protein family interactions;NCAM signaling for neurite out-growth;Regulation of signaling by CBL;Signal attenuation;Insulin receptor signalling cascade;Tie2 Signaling;Spry regulation of FGF signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Signalling to RAS;Costimulation by the CD28 family;SOS-mediated signalling;Downstream signal transduction;GAB1 signalosome;Constitutive Signaling by EGFRvIII;Signaling by FGFR4 in disease;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;SHC-related events triggered by IGF1R;GRB2:SOS provides linkage to MAPK signaling for Integrins;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR3 fusions in cancer;RET signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Negative regulation of MET activity;MET activates RAS signaling;MET activates RAP1 and RAC1;MET activates PI3K/AKT signaling;MET activates PTPN11;MET receptor recycling;InlB-mediated entry of Listeria monocytogenes into host cell;Interleukin-15 signaling;Activated NTRK2 signals through RAS;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK3 signals through RAS;Activated NTRK2 signals through PI3K;Erythropoietin activates RAS;FLT3 Signaling;STAT5 Activation	PE1	17
+NX_P62995	Transformer-2 protein homolog beta	288	33666	11.25	0	Nucleoplasm;Cytosol;Nucleus	NA	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.	Dimethylation at Arg-241 is probably asymmetric.;Phosphorylated in the RS domains.	Belongs to the splicing factor SR family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	3
+NX_P63000	Ras-related C3 botulinum toxin substrate 1	192	21450	8.77	0	Cytoplasm;Cell membrane;Nucleolus;Nucleoplasm;Lamellipodium;Melanosome;Cytosol	Mental retardation, autosomal dominant 48	Has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.;Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:1643658, PubMed:28886345). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:1643658). In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In neurons, is involved in dendritic spine formation and synaptic plasticity (By similarity). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.	(Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.;(Microbial infection) AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.;GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome.	Belongs to the small GTPase superfamily. Rho family.	MAPK signaling pathway;Chemokine signaling pathway;Phagosome;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Adherens junction;Toll-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Regulation of actin cytoskeleton;Pancreatic secretion;Amyotrophic lateral sclerosis (ALS);Bacterial invasion of epithelial cells;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Salmonella infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Viral myocarditis;MAPK6/MAPK4 signaling;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;Translocation of SLC2A4 (GLUT4) to the plasma membrane;DSCAM interactions;Factors involved in megakaryocyte development and platelet production;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;RHO GTPases Activate Formins;GPVI-mediated activation cascade;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;Rho GTPase cycle;NRAGE signals death through JNK;DAP12 signaling;FCERI mediated MAPK activation;VEGFA-VEGFR2 Pathway;Signal transduction by L1;VEGFR2 mediated vascular permeability;PCP/CE pathway;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Sema4D mediated inhibition of cell attachment and migration;Signaling by SCF-KIT;CD28 dependent Vav1 pathway;Sema3A PAK dependent Axon repulsion;Nef and signal transduction;DCC mediated attractive signaling;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate IQGAPs;RHO GTPases Activate NADPH Oxidases;RHO GTPases activate PAKs;RHO GTPases activate KTN1;Activation of RAC1;Inactivation of CDC42 and RAC1;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;Neutrophil degranulation;MET activates RAP1 and RAC1;Activated NTRK2 signals through CDK5;NTRK2 activates RAC1;Activation of RAC1 downstream of NMDARs	PE1	7
+NX_P63010	AP-2 complex subunit beta	937	104553	5.22	0	Cytoplasmic vesicle;Coated pit;Cell membrane	NA	Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.	Phosphorylation at Tyr-737 by SRC occurs at the plasma membrane in clathrin-coated vesicles (CCVs).;AP2B1 is phosphorylated by SRC;AP2B1 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the adaptor complexes large subunit family.	Endocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Huntington's disease;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Retrograde neurotrophin signalling;Recycling pathway of L1;Nef Mediated CD8 Down-regulation;WNT5A-dependent internalization of FZD4;Nef Mediated CD4 Down-regulation;Trafficking of GluR2-containing AMPA receptors;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance	PE1	17
+NX_P63027	Vesicle-associated membrane protein 2	116	12663	7.84	1	Synaptic vesicle membrane;Synaptosome;Cell membrane	NA	Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.	(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 59-Lys-|-Leu-60 bond and inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.;(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 76-Gln-|-Phe-77 bond and probably inhibits neurotransmitter release (PubMed:7803399).;(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 58-Gln-|-Lys-59 bond and probably inhibits neurotransmitter release (PubMed:19543288).;(Microbial infection) Targeted and hydrolyzed by C.tetani tetanus toxin (tetX) which hydrolyzes the 76-Gln-|-Phe-77 bond and probably inhibits neurotransmitter release (PubMed:7803399).;Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.;VAMP2 is phosphorylated by PRKCZ (Phosphoserine:PTM-0253);VAMP2 is phosphorylated by PRKD3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the synaptobrevin family.	SNARE interactions in vesicular transport;Synaptic vesicle cycle;Vasopressin-regulated water reabsorption;Salivary secretion;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;Acetylcholine Neurotransmitter Release Cycle;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;GABA synthesis, release, reuptake and degradation;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Regulation of insulin secretion;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Toxicity of botulinum toxin type D (BoNT/D);Toxicity of botulinum toxin type F (BoNT/F);Toxicity of botulinum toxin type G (BoNT/G);Toxicity of botulinum toxin type B (BoNT/B);Toxicity of tetanus toxin (TeNT);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Other interleukin signaling;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane;trans-Golgi Network Vesicle Budding	PE1	17
+NX_P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	394	45665	5.59	0	Cell membrane	Pseudohypoparathyroidism 1A;Progressive osseous heteroplasia;Pseudohypoparathyroidism 1C;Albright hereditary osteodystrophy;GNAS hyperfunction;McCune-Albright syndrome;ACTH-independent macronodular adrenal hyperplasia 1;Pseudohypoparathyroidism 1B	Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).	GNAS is phosphorylated by PTK6	Belongs to the G-alpha family. G(s) subfamily.	Calcium signaling pathway;Vascular smooth muscle contraction;Gap junction;Glutamatergic synapse;Dopaminergic synapse;Long-term depression;Taste transduction;GnRH signaling pathway;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Vasopressin-regulated water reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;Vibrio cholerae infection;Chagas disease (American trypanosomiasis);Amoebiasis;Dilated cardiomyopathy;G alpha (i) signalling events;G alpha (s) signalling events;Hedgehog 'off' state;PKA activation in glucagon signalling;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;Prostacyclin signalling through prostacyclin receptor;G alpha (z) signalling events;Glucagon-type ligand receptors	PE1	20
+NX_P63096	Guanine nucleotide-binding protein G(i) subunit alpha-1	354	40361	5.69	0	Golgi apparatus;Cytoplasm;Cell cortex;Cell membrane;Membrane;Centrosome;Nucleus	NA	Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364).	Myristoylation at Gly-2 is required for membrane anchoring before palmitoylation.;(Microbial infection) Deamidated at Gln-204 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.;Palmitoylation at Cys-3 varies with membrane lipid composition.	Belongs to the G-alpha family. G(i/o/t/z) subfamily.	Chemokine signaling pathway;Axon guidance;Tight junction;Gap junction;Leukocyte transendothelial migration;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Long-term depression;Progesterone-mediated oocyte maturation;Melanogenesis;Gastric acid secretion;Pertussis;Chagas disease (American trypanosomiasis);Toxoplasmosis;G alpha (i) signalling events;G alpha (s) signalling events;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (z) signalling events;Regulation of insulin secretion;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling	PE1	7
+NX_P63098	Calcineurin subunit B type 1	170	19300	4.64	0	Cytoplasm;Cytosol;Sarcolemma;Cell membrane	NA	Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.	NA	Belongs to the calcineurin regulatory subunit family.	MAPK signaling pathway;Calcium signaling pathway;Oocyte meiosis;Apoptosis;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Long-term potentiation;Glutamatergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Tuberculosis;FCERI mediated Ca+2 mobilization;Activation of BAD and translocation to mitochondria;DARPP-32 events;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation;Calcineurin activates NFAT	PE1	2
+NX_P63104	14-3-3 protein zeta/delta	245	27745	4.73	0	Cytoplasm;Melanosome	NA	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).	The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53.;YWHAZ is phosphorylated by IGF1R (Phosphotyrosine:PTM-0255)	Belongs to the 14-3-3 family.	Cell cycle;Oocyte meiosis;Neurotrophin signaling pathway;Pathogenic Escherichia coli infection;Translocation of SLC2A4 (GLUT4) to the plasma membrane;TP53 Regulates Metabolic Genes;Activation of BAD and translocation to mitochondria;Deactivation of the beta-catenin transactivating complex;Interleukin-3, Interleukin-5 and GM-CSF signaling;KSRP (KHSRP) binds and destabilizes mRNA;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;RHO GTPases activate PKNs;GP1b-IX-V activation signalling;Rap1 signalling;Negative regulation of NOTCH4 signaling;NOTCH4 Activation and Transmission of Signal to the Nucleus;Regulation of localization of FOXO transcription factors	PE1	8
+NX_P63119	Endogenous retrovirus group K member 21 Pro protein	156	17107	7.92	0	NA	NA	Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE3	12
+NX_P63120	Endogenous retrovirus group K member 19 Pro protein	156	17107	7.92	0	NA	NA	Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE3	19
+NX_P63121	Endogenous retrovirus group K member 113 Pro protein	156	17136	5.86	0	NA	NA	Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE3	19
+NX_P63122	Endogenous retrovirus group K member 8 Pro protein	156	17206	8.56	0	NA	NA	Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE3	8
+NX_P63123	Endogenous retrovirus group K member 18 Pro protein	156	17101	7.95	0	NA	NA	Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE3	1
+NX_P63124	Endogenous retrovirus group K member 104 Pro protein	156	17121	5.86	0	NA	NA	Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution (By similarity).	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE3	5
+NX_P63125	Endogenous retrovirus group K member 25 Pro protein	156	17077	7.92	0	NA	NA	Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases.	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE3	11
+NX_P63126	Endogenous retrovirus group K member 9 Gag polyprotein	666	74005	9.02	0	Cell membrane	NA	The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).;Specific enzymatic cleavages may yield mature proteins.	Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.	NA	PE1	6
+NX_P63127	Endogenous retrovirus group K member 9 Pro protein	156	17194	8.56	0	NA	NA	Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution (By similarity).	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE3	6
+NX_P63128	Endogenous retrovirus group K member 9 Pol protein	1117	123620	9.04	0	Cell membrane	NA	The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution (By similarity).;Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity).	Specific enzymatic cleavages may yield mature proteins.;Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).	Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.	NA	PE3	6
+NX_P63129	Endogenous retrovirus group K member 24 Pro protein	156	17139	7.92	0	NA	NA	Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases.	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE3	22
+NX_P63130	Endogenous retrovirus group K member 7 Gag polyprotein	666	74111	8.99	0	Cell membrane	NA	The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	Specific enzymatic cleavages may yield mature proteins.;Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).	Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.	NA	PE3	1
+NX_P63131	Endogenous retrovirus group K member 7 Pro protein	156	17078	5.86	0	NA	NA	Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases.	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE3	1
+NX_P63132	Endogenous retrovirus group K member 113 Pol protein	956	107766	9.06	0	NA	NA	Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	NA	Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.	NA	PE3	19
+NX_P63133	Endogenous retrovirus group K member 8 Pol protein	956	107703	9.11	0	NA	NA	Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	NA	Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.	NA	PE3	8
+NX_P63135	Endogenous retrovirus group K member 7 Pol protein	1459	165184	9.09	0	NA	NA	Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	NA	Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.	NA	PE3	1
+NX_P63136	Endogenous retrovirus group K member 25 Pol protein	954	107472	9.14	0	NA	NA	Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity).	NA	Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.	NA	PE3	11
+NX_P63145	Endogenous retrovirus group K member 24 Gag polyprotein	666	74040	8.99	0	Cell membrane	NA	The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).;Specific enzymatic cleavages may yield mature proteins.	Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.	NA	PE1	22
+NX_P63146	Ubiquitin-conjugating enzyme E2 B	152	17312	4.91	0	Nucleus;Cell membrane	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.	NA	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Recognition of DNA damage by PCNA-containing replication complex;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins	PE1	5
+NX_P63151	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	447	51692	5.82	0	NA	NA	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	NA	Belongs to the phosphatase 2A regulatory subunit B family.	mRNA surveillance pathway;Tight junction;Dopaminergic synapse;Chagas disease (American trypanosomiasis);Hepatitis C;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Initiation of Nuclear Envelope Reformation;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin D associated events in G1	PE1	8
+NX_P63162	Small nuclear ribonucleoprotein-associated protein N	240	24614	11.2	0	Nucleus	NA	May be involved in tissue-specific alternative RNA processing events.	NA	Belongs to the snRNP SmB/SmN family.	mRNA Splicing - Major Pathway	PE1	15
+NX_P63165	Small ubiquitin-related modifier 1	101	11557	5.34	0	Cytoplasm;Nucleus speckle;Cell membrane;Nucleus membrane;Nucleolus;Nucleoplasm;PML body;Nucleus	Non-syndromic orofacial cleft 10	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).	Polymeric SUMO1 chains undergo polyubiquitination by RNF4.;Cleavage of precursor form by SENP1 or SENP2 is necessary for function.	Belongs to the ubiquitin family. SUMO subfamily.	RNA transport;SUMOylation of DNA damage response and repair proteins;G2/M DNA damage checkpoint;SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);Regulation of IFNG signaling;SUMO is proteolytically processed;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of transcription factors;SUMOylation of chromatin organization proteins;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;SUMOylation of intracellular receptors;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins	PE1	2
+NX_P63167	Dynein light chain 1, cytoplasmic	89	10366	6.89	0	Mitochondrion;Centrosome;Nucleus;Cytoskeleton	NA	Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.;Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.;Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.;Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.	Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.	Belongs to the dynein light chain family.	Vasopressin-regulated water reabsorption;Separation of Sister Chromatids;Macroautophagy;Anchoring of the basal body to the plasma membrane;MHC class II antigen presentation;Intraflagellar transport;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Recruitment of NuMA to mitotic centrosomes;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Activation of BIM and translocation to mitochondria;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;AURKA Activation by TPX2;Neutrophil degranulation;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	12
+NX_P63172	Dynein light chain Tctex-type 1	113	12452	5	0	Golgi apparatus;Nucleoplasm;Spindle;Cytoplasm	NA	Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity). Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (PubMed:27502274).;Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.;(Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site.	Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIM:178600]. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity).;DYNLT1 is phosphorylated by FYN (Phosphotyrosine:PTM-0255)	Belongs to the dynein light chain Tctex-type family.	Neutrophil degranulation	PE1	6
+NX_P63173	60S ribosomal protein L38	70	8218	10.1	0	Endoplasmic reticulum;Cytosol	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL38 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	17
+NX_P63208	S-phase kinase-associated protein 1	163	18658	4.4	0	Nucleoplasm;Cytosol	NA	Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.	Undergoes autophagy-mediated degradation in the liver in a time-dependent manner.	Belongs to the SKP1 family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Wnt signaling pathway;TGF-beta signaling pathway;Circadian rhythm - mammal;Herpes simplex infection;Activation of NF-kappaB in B cells;SCF-beta-TrCP mediated degradation of Emi1;Vpu mediated degradation of CD4;Degradation of beta-catenin by the destruction complex;FCERI mediated NF-kB activation;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;Orc1 removal from chromatin;Antigen processing: Ubiquitination &amp; Proteasome degradation;Regulation of PLK1 Activity at G2/M Transition;Downstream TCR signaling;SCF(Skp2)-mediated degradation of p27/p21;Circadian Clock;Prolactin receptor signaling;Iron uptake and transport;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Cyclin D associated events in G1;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX2 expression and activity;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling	PE1	5
+NX_P63211	Guanine nucleotide-binding protein G(T) subunit gamma-T1	74	8496	4.76	0	Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the G protein gamma family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Phototransduction;G alpha (i) signalling events;Olfactory Signaling Pathway;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	7
+NX_P63215	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	75	8305	7.65	0	Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the G protein gamma family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Taste transduction;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	11
+NX_P63218	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	68	7318	9.9	0	Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the G protein gamma family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	1
+NX_P63220	40S ribosomal protein S21	83	9111	8.68	0	Endoplasmic reticulum;Cytoplasm;Cytosol;Rough endoplasmic reticulum	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eS21 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	20
+NX_P63241	Eukaryotic translation initiation factor 5A-1	154	16832	5.07	0	Cytoplasm;Endoplasmic reticulum membrane;Nuclear pore complex;Nucleoplasm;Cytosol;Nucleus	NA	MRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.	EIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).;Acetylated. Deacetylated by SIRT2.	Belongs to the eIF-5A family.	Hypusine synthesis from eIF5A-lysine	PE1	17
+NX_P63244	Receptor of activated protein C kinase 1	317	35077	7.6	0	Cytoplasm;Perinuclear region;Cell membrane;Perikaryon;Nucleoplasm;Phagocytic cup;Cytoplasmic vesicle;Dendrite;Nucleus	NA	(Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs.;(Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses.;(Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs.;(Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells.;Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158).	Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC.;(Microbial infection) Phosphorylated by vaccinia virus B1 kinase on serine and threonine residues; this phosphorylation remodels the ribosome properties, favoring the viral mRNA translation.	Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.	Measles;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production	PE1	5
+NX_P63252	Inward rectifier potassium channel 2	427	48288	5.47	2	Membrane	Short QT syndrome 3;Long QT syndrome 7;Atrial fibrillation, familial, 9	Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.	S-nitrosylation increases the open probability and inward rectifying currents.	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.	Cholinergic synapse;Gastric acid secretion;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Classical Kir channels;Phase 4 - resting membrane potential	PE1	17
+NX_P63261	Actin, cytoplasmic 2	375	41793	5.31	0	Cytoplasm;Cytoskeleton	Deafness, autosomal dominant, 20;Baraitser-Winter syndrome 2	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.;Methylated at His-73 by SETD3.;Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.;(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).;Actin, cytoplasmic 2, N-terminally processed: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins (PubMed:29581253). In contrast, filament nucleation by the Arp2/3 complex is not affected (PubMed:29581253).	Belongs to the actin family.	Phagosome;Focal adhesion;Adherens junction;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Vibrio cholerae infection;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Influenza A;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Viral myocarditis;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases Activate Formins;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Recycling pathway of L1;MAP2K and MAPK activation;Adherens junctions interactions;Gap junction degradation;RHO GTPases activate IQGAPs;Formation of annular gap junctions;Cell-extracellular matrix interactions;Clathrin-mediated endocytosis;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	17
+NX_P63267	Actin, gamma-enteric smooth muscle	376	41877	5.31	0	Cytoskeleton	Visceral myopathy	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.;Methylated at His-74 by SETD3.;Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.;(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-51 of one monomer and Glu-271 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).	Belongs to the actin family.	Vascular smooth muscle contraction;Smooth Muscle Contraction	PE1	2
+NX_P63272	Transcription elongation factor SPT4	117	13193	8.29	0	Nucleoplasm;Nucleus	NA	Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.	NA	Belongs to the SPT4 family.	Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;RNA polymerase II transcribes snRNA genes;TP53 Regulates Transcription of DNA Repair Genes	PE1	17
+NX_P63279	SUMO-conjugating enzyme UBC9	158	18007	8.87	0	Cytoplasm;Nucleus	NA	Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705).	Phosphorylation at Ser-71 significantly enhances SUMOylation activity.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein sumoylation.;RNA transport;Ubiquitin mediated proteolysis;SUMOylation of DNA damage response and repair proteins;Meiotic synapsis;Vitamin D (calciferol) metabolism;SUMO is transferred from E1 to E2 (UBE2I, UBC9);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of transcription factors;SUMOylation of chromatin organization proteins;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;SUMOylation of intracellular receptors;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins	PE1	16
+NX_P63302	Selenoprotein W	87	9448	9.3	0	Cytoplasm	NA	Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).	NA	Belongs to the SelWTH family. Selenoprotein W subfamily.	NA	PE1	19
+NX_P63313	Thymosin beta-10	44	5026	5.31	0	Cytoskeleton	NA	Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).	NA	Belongs to the thymosin beta family.	NA	PE1	2
+NX_P63316	Troponin C, slow skeletal and cardiac muscles	161	18403	4.04	0	Nucleoplasm;Mitochondrion;Cytoskeleton	Cardiomyopathy, familial hypertrophic 13;Cardiomyopathy, dilated 1Z	Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.	NA	Belongs to the troponin C family.	Calcium signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Striated Muscle Contraction	PE1	3
+NX_P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	309	35594	5.3	0	Spindle pole;Cytoplasm;Centromere;Nucleus	Neurodevelopmental disorder and language delay with or without structural brain abnormalities	PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.	Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.;Polyubiquitinated, leading to its degradation by the proteasome.;Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.;PPP2CA is phosphorylated by CSNK2A1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PPP2CA is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the PPP phosphatase family. PP-1 subfamily.	mRNA surveillance pathway;Oocyte meiosis;Wnt signaling pathway;TGF-beta signaling pathway;Tight junction;Dopaminergic synapse;Long-term depression;Chagas disease (American trypanosomiasis);Hepatitis C;Degradation of beta-catenin by the destruction complex;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Negative regulation of MAPK pathway;Initiation of Nuclear Envelope Reformation;Cyclin A/B1/B2 associated events during G2/M transition;MASTL Facilitates Mitotic Progression;RAF activation;DARPP-32 events;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Cyclin D associated events in G1;CTLA4 inhibitory signaling;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Spry regulation of FGF signaling;Platelet sensitization by LDL;ERK/MAPK targets;Integration of energy metabolism;PP2A-mediated dephosphorylation of key metabolic factors;ERKs are inactivated;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Regulation of TP53 Degradation;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	5
+NX_P67809	Y-box-binding protein 1	324	35924	9.87	0	Cytoplasm;Extracellular exosome;Secreted;Nucleolus;Cytoplasmic vesicle;Cytosol;Cytoplasmic granule;Nucleus	NA	DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:8188694, PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:8188694, PubMed:18809583). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673).	Ubiquitinated by RBBP6; leading to a decrease of YBX1 transcactivational ability.;In the absence of phosphorylation the protein is retained in the cytoplasm.;Cleaved by a 20S proteasomal protease in response to agents that damage DNA. Cleavage takes place in the absence of ubiquitination and ATP. The resulting N-terminal fragment accumulates in the nucleus (By similarity).	Belongs to the YBX1 family.	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Noncanonical activation of NOTCH3	PE1	1
+NX_P67812	Signal peptidase complex catalytic subunit SEC11A	179	20625	9.48	1	Microsome membrane;Endoplasmic reticulum membrane	NA	Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.	NA	Belongs to the peptidase S26B family.	Protein export;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);SRP-dependent cotranslational protein targeting to membrane;Synthesis, secretion, and deacylation of Ghrelin	PE1	15
+NX_P67870	Casein kinase II subunit beta	215	24942	5.33	0	NA	NA	Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.	Phosphorylated by alpha subunit.	Belongs to the casein kinase 2 subunit beta family.	Ribosome biogenesis in eukaryotes;Wnt signaling pathway;Adherens junction;Tight junction;Measles;Herpes simplex infection;Synthesis of PC;Signal transduction by L1;Condensation of Prometaphase Chromosomes;WNT mediated activation of DVL;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Regulation of TP53 Activity through Phosphorylation;Neutrophil degranulation;Receptor Mediated Mitophagy;Regulation of PTEN stability and activity;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	6
+NX_P67936	Tropomyosin alpha-4 chain	248	28522	4.67	0	Cytoplasm;Cytosol;Cytoskeleton	NA	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432).	NA	Belongs to the tropomyosin family.	Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Striated Muscle Contraction;Smooth Muscle Contraction	PE1	19
+NX_P68032	Actin, alpha cardiac muscle 1	377	42019	5.23	0	Cytoskeleton	Cardiomyopathy, familial hypertrophic 11;Atrial septal defect 5;Cardiomyopathy, dilated 1R	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.;Methylated at His-75 by SETD3.;Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.;(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).	Belongs to the actin family.	Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Striated Muscle Contraction	PE1	15
+NX_P68036	Ubiquitin-conjugating enzyme E2 L3	154	17862	8.68	0	Cytoplasm;Nucleus	NA	Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.	Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation. Autoubiquitinated in vitro (PubMed:22496338).	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Parkinson's disease;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins	PE1	22
+NX_P68104	Elongation factor 1-alpha 1	462	50141	9.1	0	Cytoplasm;Nucleolus;Nucleus;Cell membrane	NA	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.	Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2 (PubMed:26497934).;ISGylated.;Trimethylated at Lys-79 by EEF1AKMT1 (PubMed:26545399). Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation (PubMed:28108655). Trimethylated at Lys-318 by EEF1AKMT2 (PubMed:25144183). Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs (PubMed:28520920). Trimethylated at Gly-2 by EEF1AKNMT (PubMed:30143613). Mono- and dimethylated at Lys-55 by EEF1AKNMT; dimethylated form is predominant (PubMed:30143613, PubMed:30612740).;EEF1A1 is phosphorylated by TXK (Phosphotyrosine:PTM-0255);EEF1A1 is phosphorylated by RAF1 (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254)	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	RNA transport;Legionellosis;Peptide chain elongation;HSF1 activation;Eukaryotic Translation Elongation;Neutrophil degranulation;Protein methylation;Chaperone Mediated Autophagy	PE1	6
+NX_P68106	Peptidyl-prolyl cis-trans isomerase FKBP1B	108	11783	8.62	0	Sarcoplasmic reticulum;Cytoplasm;Cytoplasmic vesicle	NA	Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.	NA	Belongs to the FKBP-type PPIase family. FKBP1 subfamily.	Stimuli-sensing channels;Ion homeostasis	PE1	2
+NX_P68133	Actin, alpha skeletal muscle	377	42051	5.23	0	Cytoskeleton	Myopathy, actin, congenital, with excess of thin myofilaments;Nemaline myopathy 3;Myopathy, scapulohumeroperoneal;Myopathy, congenital, with fiber-type disproportion	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.;Methylated at His-75 by SETD3.;(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).;Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.	Belongs to the actin family.	Striated Muscle Contraction	PE1	1
+NX_P68363	Tubulin alpha-1B chain	451	50152	4.94	0	Cytoplasm;Cytoskeleton	NA	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution.;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.;Detyrosinated tubulin alpha-1B chain: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).;Tubulin alpha-1B chain: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules (PubMed:26972003). In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).;Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	12
+NX_P68366	Tubulin alpha-4A chain	448	49924	4.95	0	Cytoskeleton	Amyotrophic lateral sclerosis 22, with or without frontotemporal dementia	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.;TUBA4A is phosphorylated by ABL2 (Phosphotyrosine:PTM-0255)	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;MHC class II antigen presentation;Intraflagellar transport;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Platelet degranulation;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;AURKA Activation by TPX2;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	2
+NX_P68371	Tubulin beta-4B chain	445	49831	4.79	0	Cytoplasm;Cytoskeleton	Leber congenital amaurosis with early-onset deafness	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;MHC class II antigen presentation;Intraflagellar transport;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;AURKA Activation by TPX2;COPI-dependent Golgi-to-ER retrograde traffic;Neutrophil degranulation;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	9
+NX_P68400	Casein kinase II subunit alpha	391	45144	7.29	0	Nucleus	Okur-Chung neurodevelopmental syndrome	Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073).	Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.	Ribosome biogenesis in eukaryotes;Wnt signaling pathway;Adherens junction;Tight junction;Measles;Herpes simplex infection;Synthesis of PC;Signal transduction by L1;Condensation of Prometaphase Chromosomes;WNT mediated activation of DVL;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Regulation of TP53 Activity through Phosphorylation;Receptor Mediated Mitophagy;Regulation of PTEN stability and activity;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	20
+NX_P68402	Platelet-activating factor acetylhydrolase IB subunit beta	229	25569	5.57	0	Cytoplasm;Cytosol;Nucleolus;Cell membrane	NA	Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit.	NA	Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.	Ether lipid metabolism;Metabolic pathways;COPI-independent Golgi-to-ER retrograde traffic;Neutrophil degranulation	PE1	11
+NX_P68431	Histone H3.1	136	15404	11.13	0	Nucleus;Chromosome	Glioma	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.;Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.;Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:30257210). Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac) (PubMed:30257210).;Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.;Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.;Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin.;Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes (PubMed:29211711). It gives a specific tag for epigenetic transcription activation (PubMed:29211711).;Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.;Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.	Belongs to the histone H3 family.	Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Transcriptional regulation by small RNAs;PKMTs methylate histone lysines;RMTs methylate histone arginines;Factors involved in megakaryocyte development and platelet production;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Interleukin-7 signaling;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;HDMs demethylate histones;Chromatin modifying enzymes;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_P68543	UBX domain-containing protein 2A	259	29278	5.91	0	Cytoplasm;Centrosome;Nucleus	NA	NA	NA	NA	NA	PE1	2
+NX_P68871	Hemoglobin subunit beta	147	15998	6.74	0	Cytoplasm;Nucleus	Beta-thalassemia;Sickle cell anemia;Beta-thalassemia, dominant, inclusion body type;Heinz body anemias	LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.;Involved in oxygen transport from the lung to the various peripheral tissues.;Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.	Glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage. This takes place slowly and continuously throughout the 120-day life span of the red blood cell. The rate of glycation is increased in patients with diabetes mellitus.;Acetylated on Lys-60, Lys-83 and Lys-145 upon aspirin exposure.;S-nitrosylated; a nitric oxide group is first bound to Fe(2+) and then transferred to Cys-94 to allow capture of O(2).	Belongs to the globin family.	African trypanosomiasis;Malaria;Factors involved in megakaryocyte development and platelet production;Scavenging of heme from plasma;Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Neutrophil degranulation;Chaperone Mediated Autophagy;Microautophagy	PE1	11
+NX_P69849	Nodal modulator 3	1222	134134	5.44	1	Membrane	NA	May antagonize Nodal signaling.	NA	NA	NA	PE2	16
+NX_P69891	Hemoglobin subunit gamma-1	147	16140	6.64	0	NA	NA	Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.	Acetylation of Gly-2 converts Hb F to the minor Hb F1.	Belongs to the globin family.	Factors involved in megakaryocyte development and platelet production	PE1	11
+NX_P69892	Hemoglobin subunit gamma-2	147	16126	6.64	0	NA	Cyanosis transient neonatal	Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.	Acetylation of Gly-2 converts Hb F to the minor Hb F1.	Belongs to the globin family.	Factors involved in megakaryocyte development and platelet production	PE1	11
+NX_P69905	Hemoglobin subunit alpha	142	15258	8.72	0	NA	Alpha-thalassemia;Hemoglobin H disease;Heinz body anemias	Involved in oxygen transport from the lung to the various peripheral tissues.	The initiator Met is not cleaved in variant Thionville and is acetylated.	Belongs to the globin family.	African trypanosomiasis;Malaria;African trypanosomiasis;Malaria;Scavenging of heme from plasma;Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide	PE1	16
+NX_P78310	Coxsackievirus and adenovirus receptor	365	40030	7.49	1	Cell membrane;Basolateral cell membrane;Adherens junction;Cell junction;Secreted;Tight junction	NA	(Microbial infection) Acts as a receptor for adenovirus type C.;Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.;(Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.	Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.;N-glycosylated.	NA	Viral myocarditis;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall	PE1	21
+NX_P78312	Protein FAM193A	1265	139988	6.04	0	Cytosol;Cell membrane	NA	NA	NA	Belongs to the FAM193 family.	NA	PE1	4
+NX_P78314	SH3 domain-binding protein 2	561	62244	7.67	0	Nucleoplasm;Cytoskeleton	Cherubism	Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.	Phosphorylated. Phosphorylation at Tyr-448 may stimulate the activity of the LYN kinase (By similarity).	NA	Natural killer cell mediated cytotoxicity	PE1	4
+NX_P78316	Nucleolar protein 14	857	97668	7.33	0	Nucleoplasm;Nucleolus	NA	Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).	NA	Belongs to the NOP14 family.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	4
+NX_P78317	E3 ubiquitin-protein ligase RNF4	190	21319	6.59	0	Cytoplasm;Nucleoplasm;PML body;Nucleus;Cytoskeleton	NA	E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.	Autoubiquitinated.;Sumoylated; conjugated by one or two SUMO1 moieties.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Processing of DNA double-strand break ends	PE1	4
+NX_P78318	Immunoglobulin-binding protein 1	339	39222	5.26	0	Cytoplasm;Cytoskeleton	Mental retardation, X-linked, syndromic, 28	Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.	Phosphorylated.;Monoubiquitination by MID1 triggers calpain-mediated cleavage and switches IGBP1 activity from protective to destructive.	Belongs to the IGBP1/TAP42 family.	NA	PE1	X
+NX_P78324	Tyrosine-protein phosphatase non-receptor type substrate 1	504	54967	6.51	1	Membrane	NA	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.	N-glycosylated.;Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.;SIRPA is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	NA	Osteoclast differentiation;Cell surface interactions at the vascular wall;Signal regulatory protein family interactions;Neutrophil degranulation	PE1	20
+NX_P78325	Disintegrin and metalloproteinase domain-containing protein 8	824	88771	7.63	1	Membrane	NA	Possible involvement in extravasation of leukocytes.	NA	NA	Degradation of the extracellular matrix;Neutrophil degranulation	PE1	10
+NX_P78329	Cytochrome P450 4F2	520	59853	6.6	0	Microsome membrane;Endoplasmic reticulum membrane	Coumarin resistance	A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:18577768, PubMed:10833273, PubMed:10660572, PubMed:11997390, PubMed:17341693, PubMed:18574070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) (PubMed:18577768). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10660572, PubMed:17341693, PubMed:18574070). Plays a role in the oxidative inactivation of eicosanoids, including both proinflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:8026587, PubMed:9799565, PubMed:10833273, PubMed:10660572, PubMed:17341693, PubMed:18574070, PubMed:18577768). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids (PubMed:18065749). Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites (PubMed:15145985). Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening (PubMed:16547005, PubMed:18182499). Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues (PubMed:11997390). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:19297519, PubMed:24138531).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; arachidonate metabolism.;Lipid metabolism; leukotriene B4 degradation.;Cofactor degradation; phylloquinone degradation.;Arachidonic acid metabolism;Metabolic pathways;Miscellaneous substrates;Fatty acids;Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE);Eicosanoids;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	19
+NX_P78330	Phosphoserine phosphatase	225	25008	5.53	0	Cytosol	Phosphoserine phosphatase deficiency	Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.	NA	Belongs to the HAD-like hydrolase superfamily. SerB family.	Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.;Glycine, serine and threonine metabolism;Metabolic pathways;Serine biosynthesis	PE1	7
+NX_P78332	RNA-binding protein 6	1123	128644	5.93	0	Cytosol;Nucleus speckle;Nucleus	NA	Specifically binds poly(G) RNA homopolymers in vitro.	NA	NA	NA	PE1	3
+NX_P78333	Glypican-5	572	63707	6.38	0	Nucleoplasm;Cytosol;Cell membrane;Extracellular space	NA	Cell surface proteoglycan that bears heparan sulfate.	NA	Belongs to the glypican family.	Retinoid metabolism and transport;HS-GAG biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Release of Hh-Np from the secreting cell;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	13
+NX_P78334	Gamma-aminobutyric acid receptor subunit epsilon	506	57972	8.36	4	Postsynaptic cell membrane;Cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse	PE2	X
+NX_P78337	Pituitary homeobox 1	314	34128	9.13	0	Nucleolus;Nucleus	Liebenberg syndrome;Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.	NA	Belongs to the paired homeobox family. Bicoid subfamily.	NA	PE1	5
+NX_P78344	Eukaryotic translation initiation factor 4 gamma 2	907	102362	6.7	0	Cytosol	NA	Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.	Phosphorylation; hyperphosphorylated during mitosis.	Belongs to the eukaryotic initiation factor 4G family.	RNA transport;Viral myocarditis;ISG15 antiviral mechanism	PE1	11
+NX_P78345	Ribonuclease P protein subunit p38	283	31834	9.94	0	Nucleolus	NA	Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9037013, PubMed:9630247, PubMed:10444065, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).	NA	Belongs to the eukaryotic ribosomal protein eL8 family.	Ribosome biogenesis in eukaryotes;RNA transport;tRNA processing in the nucleus;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	10
+NX_P78346	Ribonuclease P protein subunit p30	268	29321	9.11	0	Nucleoplasm;Cytosol;Nucleolus;Cytoskeleton	NA	Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9037013, PubMed:9630247, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).	NA	Belongs to the eukaryotic/archaeal RNase P protein component 3 family.	Ribosome biogenesis in eukaryotes;RNA transport;tRNA processing in the nucleus;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	10
+NX_P78347	General transcription factor II-I	998	112416	6.09	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.	Sumoylated.;Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation.;GTF2I is phosphorylated by ITK (Phosphotyrosine:PTM-0255);GTF2I is phosphorylated by BTK (Phosphotyrosine:PTM-0255)	Belongs to the TFII-I family.	Basal transcription factors;Herpes simplex infection	PE1	7
+NX_P78348	Acid-sensing ion channel 1	528	59909	5.48	2	Golgi apparatus;Cell membrane	NA	Function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency.;Does not display proton-gated cation channel activity.;Can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.;Can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.	Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel.	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily.	Stimuli-sensing channels	PE1	12
+NX_P78352	Disks large homolog 4	724	80495	5.58	0	Cytoplasm;Dendritic spine;Cell membrane;Presynapse;Postsynaptic density;Synapse;Axon;Dendrite	NA	Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.	Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis.;Palmitoylated (PubMed:26701913). Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses (By similarity). Palmitoylation may play a role in glutamate receptor GRIA1 synapse clustering (By similarity). Depalmitoylated by ABHD17A and ABHD17B and to a lesser extent by ABHD17C, ABHD12, ABHD13, LYPLA1 and LYPLA2 (PubMed:26701913). Undergoes rapid synaptic palmitoylation/depalmitoylation cycles during neuronal development which slow down in mature neurons (By similarity).	Belongs to the MAGUK family.	Glutamatergic synapse;Huntington's disease;RAF/MAP kinase cascade;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;Signaling by ERBB4;Trafficking of AMPA receptors;LGI-ADAM interactions;NrCAM interactions;Activation of Ca-permeable Kainate Receptor;RHO GTPases activate CIT;Synaptic adhesion-like molecules;Neurexins and neuroligins;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	17
+NX_P78356	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	416	47378	6.9	0	Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Nucleoplasm;Nucleus	NA	Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.	Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels.	NA	Inositol phosphate metabolism;Phosphatidylinositol signaling system;Regulation of actin cytoskeleton;Synthesis of PIPs at the plasma membrane;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PI5P Regulates TP53 Acetylation;Synthesis of PIPs in the nucleus	PE1	17
+NX_P78357	Contactin-associated protein 1	1384	156267	6.61	1	Membrane;Nucleoplasm;Paranodal septate junction	Lethal congenital contracture syndrome 7;Neuropathy, congenital hypomyelinating, 3	Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.	NA	Belongs to the neurexin family.	Cell adhesion molecules (CAMs);Neurofascin interactions	PE1	17
+NX_P78358	Cancer/testis antigen 1	180	17992	8.79	0	Cytoplasm	NA	NA	NA	Belongs to the CTAG/PCC1 family.	NA	PE1	X
+NX_P78362	SRSF protein kinase 2	688	77527	4.87	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.	Proteolytically cleaved at Asp-139 and Asp-403 by caspase-3 during apoptotic cell death. Cleavage at Asp-139 which is the major site of cleavage, produces a small N-terminal fragment that translocates into nucleus and promotes VP16-induced apoptosis.;Phosphorylation at Thr-492 by PKB/AKT1 enhances its stimulatory activity in triggering cyclin-D1 (CCND1) expression and promoting apoptosis in neurons, which can be blocked by YWHAB. It also enhances its protein kinase activity toward ACIN1 and SRSF2, promotes its nuclear translocation and prevents its proteolytic cleavage.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.	NA	PE1	7
+NX_P78363	Retinal-specific phospholipid-transporting ATPase ABCA4	2273	255944	5.89	12	Membrane;Endoplasmic reticulum	Macular degeneration, age-related, 2;Stargardt disease 1;Cone-rod dystrophy 3;Fundus flavimaculatus;Retinitis pigmentosa 19	Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylethanolamine (PubMed:24097981). In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.	NA	Belongs to the ABC transporter superfamily. ABCA family.	ABC transporters;The canonical retinoid cycle in rods (twilight vision);ABC-family proteins mediated transport;Retinoid cycle disease events	PE1	1
+NX_P78364	Polyhomeotic-like protein 1	1004	105534	9.17	0	Nucleoplasm;Nucleus	Microcephaly 11, primary, autosomal recessive	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.	NA	NA	SUMOylation of DNA damage response and repair proteins;Oxidative Stress Induced Senescence;SUMOylation of RNA binding proteins;SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins	PE1	12
+NX_P78367	Homeobox protein Nkx-3.2	333	34814	8.12	0	Nucleoplasm;Nucleus	Spondylo-megaepiphyseal-metaphyseal dysplasia	Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity).	NA	Belongs to the NK-3 homeobox family.	Regulation of RUNX2 expression and activity	PE1	4
+NX_P78368	Casein kinase I isoform gamma-2	415	47457	9.16	0	Cytoplasmic vesicle;Cytoplasm	NA	Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.	Autophosphorylated.	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.	Hedgehog signaling pathway;Sphingolipid de novo biosynthesis;Disassembly of the destruction complex and recruitment of AXIN to the membrane	PE1	19
+NX_P78369	Claudin-10	228	24488	8.32	4	Tight junction;Cell membrane	HELIX syndrome	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28771254, PubMed:28686597).	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	13
+NX_P78371	T-complex protein 1 subunit beta	535	57488	6.01	0	Cytoplasm;Cytosol	NA	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).	NA	Belongs to the TCP-1 chaperonin family.	BBSome-mediated cargo-targeting to cilium;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Neutrophil degranulation	PE1	12
+NX_P78380	Oxidized low-density lipoprotein receptor 1	273	30959	6.94	1	Cell membrane;Secreted;Nucleoplasm;Cytoplasmic vesicle;Membrane raft	NA	Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.	N-glycosylated.;The intrachain disulfide-bonds prevent N-glycosylation at some sites.	NA	PPAR signaling pathway;Phagosome;Cell surface interactions at the vascular wall;Neutrophil degranulation	PE1	12
+NX_P78381	UDP-galactose translocator	396	41307	9.98	10	Golgi apparatus;Golgi apparatus membrane	Congenital disorder of glycosylation 2M	Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function.	NA	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.	Transport of nucleotide sugars;Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)	PE1	X
+NX_P78382	CMP-sialic acid transporter	337	36779	9.11	10	Golgi apparatus membrane	Congenital disorder of glycosylation 2F	Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function (PubMed:15576474). Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter. Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (By similarity).	NA	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.	Transport of nucleotide sugars;Sialic acid metabolism;Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F);Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)	PE1	6
+NX_P78383	Solute carrier family 35 member B1	322	35760	9.36	8	Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum membrane;Cytoplasmic vesicle	NA	Probable sugar transporter.	NA	Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.	NA	PE1	17
+NX_P78385	Keratin, type II cuticular Hb3	493	54195	5.54	0	NA	Monilethrix;Erythrokeratodermia variabilis et progressiva 5	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_P78386	Keratin, type II cuticular Hb5	507	55802	6.27	0	NA	Ectodermal dysplasia 4, hair/nail type	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_P78395	Melanoma antigen preferentially expressed in tumors	509	57890	6.44	0	Nucleoplasm;Nucleus;Cell membrane	NA	Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.	NA	Belongs to the PRAME family.	NA	PE1	22
+NX_P78396	Cyclin-A1	465	52358	4.99	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.	Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.	Belongs to the cyclin family. Cyclin AB subfamily.	Cell cycle;Progesterone-mediated oocyte maturation;Pathways in cancer;Acute myeloid leukemia;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SCF(Skp2)-mediated degradation of p27/p21;G0 and Early G1;G1/S-Specific Transcription;Cyclin A/B1/B2 associated events during G2/M transition;Regulation of APC/C activators between G1/S and early anaphase;Cyclin A:Cdk2-associated events at S phase entry;Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes;G2 Phase;p53-Dependent G1 DNA Damage Response;Processing of DNA double-strand break ends;Regulation of TP53 Activity through Phosphorylation;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Degradation;Ub-specific processing proteases	PE1	13
+NX_P78406	mRNA export factor	368	40968	7.96	0	Cytoplasm;Nucleolus;Nucleoplasm;Spindle pole;Nucleus	NA	Plays a role in mitotic bipolar spindle formation (PubMed:17172455). Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.	NA	Belongs to the WD repeat rae1 family.	RNA transport;Influenza A;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	20
+NX_P78410	Butyrophilin subfamily 3 member A2	334	36428	5.23	1	Cell membrane	NA	Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.	N-glycosylated.	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Butyrophilin (BTN) family interactions	PE1	6
+NX_P78411	Iroquois-class homeodomain protein IRX-5	483	50361	6.03	0	Cytosol;Nucleus speckle;Nucleus;Cytoskeleton	Hamamy syndrome	Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.	NA	Belongs to the TALE/IRO homeobox family.	NA	PE1	16
+NX_P78412	Iroquois-class homeodomain protein IRX-6	446	48240	5.81	0	Nucleoplasm;Mitochondrion;Nucleus	NA	NA	NA	Belongs to the TALE/IRO homeobox family.	NA	PE2	16
+NX_P78413	Iroquois-class homeodomain protein IRX-4	519	54445	5.84	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Likely to be an important mediator of ventricular differentiation during cardiac development.	NA	Belongs to the TALE/IRO homeobox family.	NA	PE1	5
+NX_P78414	Iroquois-class homeodomain protein IRX-1	480	49621	5.78	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the TALE/IRO homeobox family.	NA	PE1	5
+NX_P78415	Iroquois-class homeodomain protein IRX-3	501	52119	4.88	0	Cytoplasmic vesicle;Nucleus	NA	Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.	NA	Belongs to the TALE/IRO homeobox family.	NA	PE1	16
+NX_P78417	Glutathione S-transferase omega-1	241	27566	6.24	0	Nucleoplasm;Cytosol	NA	Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.	NA	Belongs to the GST superfamily. Omega family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Methylation;Glutathione conjugation;Vitamin C (ascorbate) metabolism;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	10
+NX_P78423	Fractalkine	397	42203	6.08	1	Secreted;Cell membrane	NA	Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350).	A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.;O-glycosylated with core 1 or possibly core 8 glycans.	Belongs to the intercrine delta family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	16
+NX_P78424	POU domain, class 6, transcription factor 2	691	73265	7.31	0	Nucleus	Hereditary susceptibility to Wilms tumor 5	Does not bind DNA.;Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'.	NA	Belongs to the POU transcription factor family. Class-6 subfamily.	NA	PE1	7
+NX_P78426	Homeobox protein Nkx-6.1	367	37849	9.46	0	Nucleoplasm;Nucleus	NA	Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).	NA	NA	Maturity onset diabetes of the young;Regulation of gene expression in beta cells;Regulation of gene expression in early pancreatic precursor cells	PE1	4
+NX_P78504	Protein jagged-1	1218	133799	5.7	1	Membrane;Golgi apparatus;Cell membrane	Tetralogy of Fallot;Alagille syndrome 1;Deafness, congenital heart defects, and posterior embryotoxon	Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).	NA	NA	Notch signaling pathway;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;RUNX3 regulates NOTCH signaling;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus	PE1	20
+NX_P78508	ATP-sensitive inward rectifier potassium channel 10	379	42508	8.18	2	Membrane;Basolateral cell membrane	Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance	May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.	NA	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.	Gastric acid secretion;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Potassium transport channels	PE1	1
+NX_P78509	Reelin	3460	388388	5.54	0	Extracellular matrix;Focal adhesion;Cell membrane	Lissencephaly 2;Epilepsy, familial temporal lobe, 7	Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity).	NA	Belongs to the reelin family.	Focal adhesion;ECM-receptor interaction;Reelin signalling pathway	PE1	7
+NX_P78524	Suppression of tumorigenicity 5 protein	1137	126485	9.35	0	Nucleoplasm;Cell cortex;Recycling endosome;Cell membrane	NA	May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).;Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.;May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480).	Phosphorylated. Phosphorylation decreases ITSN1 binding.	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	11
+NX_P78527	DNA-dependent protein kinase catalytic subunit	4128	469089	6.75	0	Nucleoplasm;Nucleolus;Nucleus	Immunodeficiency 26 with or without neurologic abnormalities	Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805). Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:15574326, PubMed:11955432, PubMed:12649176, PubMed:14734805). Required to protect and align broken ends of DNA (PubMed:15574326, PubMed:11955432, PubMed:12649176, PubMed:14734805). May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:15574326, PubMed:11955432, PubMed:12649176, PubMed:14734805). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription (PubMed:15574326, PubMed:11955432, PubMed:12649176, PubMed:14734805). Recognizes the substrate consensus sequence [ST]-Q (PubMed:15574326, PubMed:11955432, PubMed:12649176, PubMed:14734805). Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:2507541, PubMed:2247066, PubMed:1597196, PubMed:8407951, PubMed:8464713, PubMed:9362500, PubMed:9139719, PubMed:10026262, PubMed:10467406, PubMed:12509254, PubMed:11889123, PubMed:14612514, PubMed:14704337, PubMed:16397295, PubMed:26237645, PubMed:28712728). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).	Autophosphorylated on Ser-2056, Thr-2609, Thr-2638 and Thr-2647. Ser-2056 and Thr-2609 are DNA damage-inducible phosphorylation sites (inducible with ionizing radiation, IR) dephosphorylated by PPP5C. Autophosphorylation induces a conformational change that leads to remodeling of the DNA-PK complex, requisite for efficient end processing and DNA repair.;Polyubiquitinated by RNF144A, leading to proteasomal degradation.;S-nitrosylated by GAPDH.;PRKDC is phosphorylated by LYN (Phosphotyrosine:PTM-0255);PRKDC is phosphorylated by PRKCD;PRKDC is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	Belongs to the PI3/PI4-kinase family.	Non-homologous end-joining;Cell cycle;Cytosolic sensors of pathogen-associated DNA;IRF3-mediated induction of type I IFN;Nonhomologous End-Joining (NHEJ);E3 ubiquitin ligases ubiquitinate target proteins	PE1	8
+NX_P78536	Disintegrin and metalloproteinase domain-containing protein 17	824	93021	5.5	1	Membrane;Cytosol	Inflammatory skin and bowel disease, neonatal, 1	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity).	The precursor is cleaved by a furin endopeptidase.;Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding.	NA	Notch signaling pathway;Alzheimer's disease;Epithelial cell signaling in Helicobacter pylori infection;Collagen degradation;Nuclear signaling by ERBB4;Growth hormone receptor signaling;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Signaling by EGFR;Regulated proteolysis of p75NTR;Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant;Constitutive Signaling by NOTCH1 HD Domain Mutants;Release of Hh-Np from the secreting cell;TNF signaling	PE1	2
+NX_P78537	Biogenesis of lysosome-related organelles complex 1 subunit 1	153	17263	9.37	0	Mitochondrion intermembrane space;Mitochondrion matrix;Lysosome membrane;Cytosol	NA	May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.;Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).	NA	Belongs to the BLOC1S1 family.	Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis	PE1	12
+NX_P78539	Sushi repeat-containing protein SRPX	464	51572	8.98	0	Cell surface	NA	May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.	NA	NA	NA	PE1	X
+NX_P78540	Arginase-2, mitochondrial	354	38578	6	0	Mitochondrion	NA	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189).	NA	Belongs to the arginase family.	Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.;Arginine and proline metabolism;Metabolic pathways;Amoebiasis;Urea cycle	PE1	14
+NX_P78543	Protein BTG2	158	17416	8.29	0	Nucleoplasm;Cytoplasmic vesicle	NA	Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.	Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.	Belongs to the BTG family.	RNA degradation;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	1
+NX_P78545	ETS-related transcription factor Elf-3	371	41454	5.52	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).	NA	Belongs to the ETS family.	Pre-NOTCH Transcription and Translation	PE1	1
+NX_P78549	Endonuclease III-like protein 1	312	34390	9.72	0	Mitochondrion;Nucleus	Familial adenomatous polyposis 3	Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.	NA	Belongs to the Nth/MutY family.	Base excision repair;Displacement of DNA glycosylase by APEX1;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Defective NTHL1 substrate processing;Defective NTHL1 substrate binding	PE1	16
+NX_P78552	Interleukin-13 receptor subunit alpha-1	427	48760	5.7	1	Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.	NA	Belongs to the type I cytokine receptor family. Type 5 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-4 and Interleukin-13 signaling	PE1	X
+NX_P78556	C-C motif chemokine 20	96	10762	9.21	0	Secreted	NA	Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255).	C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Rheumatoid arthritis;G alpha (i) signalling events;Chemokine receptors bind chemokines;Interleukin-10 signaling	PE1	2
+NX_P78559	Microtubule-associated protein 1A	2803	305485	4.85	0	Cytosol;Cytoskeleton	NA	Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.	LC2 is generated from MAP1A by proteolytic processing.;Phosphorylated by CSNK1D.;MAP1A is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the MAP1 family.	NA	PE1	15
+NX_P78560	Death domain-containing protein CRADD	199	22745	6.32	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Mental retardation, autosomal recessive 34, with variant lissencephaly	Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253).	NA	NA	TP53 Regulates Transcription of Caspase Activators and Caspases	PE1	12
+NX_P78562	Phosphate-regulating neutral endopeptidase PHEX	749	86474	8.91	1	Cell membrane	Hypophosphatemic rickets, X-linked dominant	Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (PubMed:9593714, PubMed:15664000, PubMed:18162525, PubMed:18597632). Cleaves ASARM peptides between Ser and Glu or Asp residues (PubMed:18597632). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:18597632). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:18597632, PubMed:18162525). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (PubMed:12220505).	NA	Belongs to the peptidase M13 family.	NA	PE1	X
+NX_P78563	Double-stranded RNA-specific editase 1	741	80763	9.11	0	Nucleoplasm;Nucleus;Cytosol;Nucleolus	NA	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis.	NA	NA	C6 deamination of adenosine;Formation of editosomes by ADAR proteins	PE1	21
+NX_P79483	HLA class II histocompatibility antigen, DR beta 3 chain	266	29962	8.81	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;Lysosome membrane;trans-Golgi network membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Hematopoietic cell lineage;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_P79522	Proline-rich protein 3	188	20640	9.87	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	6
+NX_P80075	C-C motif chemokine 8	99	11246	9.47	0	Secreted	NA	Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.	N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway	PE1	17
+NX_P80098	C-C motif chemokine 7	99	11200	9.72	0	Secreted	NA	Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.	O-glycosylated.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway	PE1	17
+NX_P80108	Phosphatidylinositol-glycan-specific phospholipase D	840	92336	5.91	0	Secreted	NA	This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.	NA	Belongs to the GPLD1 family.	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Post-translational modification: synthesis of GPI-anchored proteins	PE1	6
+NX_P80162	C-X-C motif chemokine 6	114	11897	9.91	0	Secreted	NA	Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).	NA	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Pertussis;Rheumatoid arthritis;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	4
+NX_P80188	Neutrophil gelatinase-associated lipocalin	198	22588	9.02	0	Endoplasmic reticulum;Cytoplasmic granule lumen;Secreted;Cytoplasmic vesicle lumen	NA	Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821). Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368).	NA	Belongs to the calycin superfamily. Lipocalin family.	Iron uptake and transport;Neutrophil degranulation;Metal sequestration by antimicrobial proteins;Interleukin-4 and Interleukin-13 signaling	PE1	9
+NX_P80192	Mitogen-activated protein kinase kinase kinase 9	1104	121895	5.63	0	Nucleoplasm;Nucleolus	NA	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.	Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	NA	PE1	14
+NX_P80217	Interferon-induced 35 kDa protein	286	31546	5.75	0	Nucleoplasm;Cytosol;Nucleus	NA	Not yet known.	NA	Belongs to the NMI family.	Interferon alpha/beta signaling	PE1	17
+NX_P80294	Metallothionein-1H	61	6039	8.49	0	NA	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	NA	Belongs to the metallothionein superfamily. Type 1 family.	Mineral absorption;Metallothioneins bind metals	PE1	16
+NX_P80297	Metallothionein-1X	61	6068	8.38	0	Cytoplasm;Nucleus	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525).	NA	Belongs to the metallothionein superfamily. Type 1 family.	Mineral absorption;Metallothioneins bind metals	PE1	16
+NX_P80303	Nucleobindin-2	420	50223	5.03	0	Golgi apparatus;Cytoplasm;Secreted;Membrane;Endoplasmic reticulum;Nucleus envelope	NA	Calcium-binding protein. May have a role in calcium homeostasis.;Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity).	NA	Belongs to the nucleobindin family.	NA	PE1	11
+NX_P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	405	44127	9.42	0	Endoplasmic reticulum;Cytoplasmic vesicle;Microsome	Apparent mineralocorticoid excess	Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Steroid hormone biosynthesis;Metabolism of xenobiotics by cytochrome P450;Metabolic pathways;Aldosterone-regulated sodium reabsorption;Glucocorticoid biosynthesis	PE1	16
+NX_P80370	Protein delta homolog 1	383	41300	5.43	1	Membrane;Cytoplasm;Golgi apparatus	NA	May have a role in neuroendocrine differentiation.	N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.	NA	Activated NOTCH1 Transmits Signal to the Nucleus	PE1	14
+NX_P80404	4-aminobutyrate aminotransferase, mitochondrial	500	56439	8.17	0	Mitochondrion matrix;Mitochondrion	GABA transaminase deficiency	Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.	NA	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Alanine, aspartate and glutamate metabolism;Valine, leucine and isoleucine degradation;beta-Alanine metabolism;Propanoate metabolism;Butanoate metabolism;Metabolic pathways;GABAergic synapse;Degradation of GABA	PE1	16
+NX_P80511	Protein S100-A12	92	10575	5.83	0	Cytoplasm;Secreted;Cell membrane;Cytoskeleton	NA	S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.	NA	Belongs to the S-100 family.	Advanced glycosylation endproduct receptor signaling;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;Neutrophil degranulation	PE1	1
+NX_P80723	Brain acid soluble protein 1	227	22693	4.64	0	Growth cone;Cell membrane	NA	NA	NA	Belongs to the BASP1 family.	NA	PE1	5
+NX_P80748	Immunoglobulin lambda variable 3-21	117	12446	5.03	0	Secreted;Cell membrane	NA	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).	NA	NA	FCERI mediated NF-kB activation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of actin dynamics for phagocytic cup formation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Cell surface interactions at the vascular wall;Regulation of Complement cascade;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;Initial triggering of complement;Classical antibody-mediated complement activation;FCGR activation;Scavenging of heme from plasma;Fc epsilon receptor (FCERI) signaling;CD22 mediated BCR regulation	PE1	22
+NX_P81133	Single-minded homolog 1	766	85515	7.03	0	Nucleus speckle;Nucleus	NA	Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.	NA	NA	NA	PE1	6
+NX_P81172	Hepcidin	84	9408	9.24	0	Secreted	Hemochromatosis 2B	Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317).;Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).	NA	Belongs to the hepcidin family.	NA	PE1	19
+NX_P81274	G-protein-signaling modulator 2	684	76662	5.97	0	Cytoplasm;Cell cortex;Lateral cell membrane;Spindle pole;Cytosol	Chudley-McCullough syndrome	Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays also an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity).	NA	Belongs to the GPSM family.	G alpha (i) signalling events	PE1	1
+NX_P81277	Prolactin-releasing peptide	87	9639	11.66	0	Secreted	NA	Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.	NA	NA	Peptide ligand-binding receptors	PE1	2
+NX_P81408	Protein FAM189B	668	71355	8.87	4	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the FAM189 family.	NA	PE1	1
+NX_P81534	Beta-defensin 103	67	7697	10.15	0	Secreted;Nucleus	NA	Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	8
+NX_P81605	Dermcidin	110	11284	6.09	0	Secreted	NA	Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.;DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443).	NA	NA	Antimicrobial peptides	PE1	12
+NX_P81877	Single-stranded DNA-binding protein 2	361	37828	6.16	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	5
+NX_P82094	TATA element modulatory factor	1093	122842	4.88	0	Golgi apparatus;Cytoplasm;Nucleus;Golgi apparatus membrane	NA	Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).	Phosphorylated by FER.;TMF1 is phosphorylated by FER	NA	Retrograde transport at the Trans-Golgi-Network	PE1	3
+NX_P82251	b(0,+)-type amino acid transporter 1	487	53481	8.4	12	Apical cell membrane	Cystinuria	Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule.	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily.	Protein digestion and absorption;Amino acid transport across the plasma membrane;Basigin interactions;Defective SLC3A1 causes cystinuria (CSNU);Defective SLC7A9 causes cystinuria (CSNU)	PE1	19
+NX_P82279	Protein crumbs homolog 1	1406	154183	4.84	1	Cytoplasmic vesicle;Apical cell membrane;Secreted	Leber congenital amaurosis 8;Retinitis pigmentosa 12;Pigmented paravenous chorioretinal atrophy	Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.	Extensively glycosylated.	Belongs to the Crumbs protein family.	NA	PE1	1
+NX_P82650	28S ribosomal protein S22, mitochondrial	360	41280	7.7	0	Mitochondrion	Combined oxidative phosphorylation deficiency 5;Ovarian dysgenesis 7	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mS22 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	3
+NX_P82663	28S ribosomal protein S25, mitochondrial	173	20116	8.99	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mS25 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	3
+NX_P82664	28S ribosomal protein S10, mitochondrial	201	22999	7.78	0	Mitochondrion;Cytoskeleton	NA	NA	NA	Belongs to the universal ribosomal protein uS10 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	6
+NX_P82673	28S ribosomal protein S35, mitochondrial	323	36844	8.41	0	Cytosol;Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mS35 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	12
+NX_P82675	28S ribosomal protein S5, mitochondrial	430	48006	9.93	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uS5 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	2
+NX_P82909	28S ribosomal protein S36, mitochondrial	103	11466	9.99	0	Mitochondrion	NA	NA	NA	NA	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	5
+NX_P82912	28S ribosomal protein S11, mitochondrial	194	20616	10.82	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uS11 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	15
+NX_P82914	28S ribosomal protein S15, mitochondrial	257	29842	10.48	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uS15 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	1
+NX_P82921	28S ribosomal protein S21, mitochondrial	87	10689	9.96	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bS21 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	1
+NX_P82930	28S ribosomal protein S34, mitochondrial	218	25650	9.98	0	Mitochondrion	Combined oxidative phosphorylation deficiency 32	Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.	NA	Belongs to the mitochondrion-specific ribosomal protein mS34 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	16
+NX_P82932	28S ribosomal protein S6, mitochondrial	125	14227	9.3	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bS6 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	21
+NX_P82933	28S ribosomal protein S9, mitochondrial	396	45835	9.54	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uS9 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	2
+NX_P82970	High mobility group nucleosome-binding domain-containing protein 5	282	31525	4.5	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.	NA	Belongs to the HMGN family.	NA	PE1	X
+NX_P82979	SAP domain-containing ribonucleoprotein	210	23671	6.1	0	Cytosol;Nucleus speckle;Nucleus	NA	Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.	NA	NA	Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	12
+NX_P82980	Retinol-binding protein 5	135	15931	6.09	0	Golgi apparatus;Cytoplasmic vesicle;Cytoplasm	NA	Intracellular transport of retinol.	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	NA	PE1	12
+NX_P82987	ADAMTS-like protein 3	1691	188692	8.2	0	Cytoplasmic vesicle;Extracellular matrix	NA	NA	Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	15
+NX_P83105	Serine protease HTRA4	476	50979	8.37	0	Secreted	NA	Serine protease.	NA	Belongs to the peptidase S1C family.	NA	PE1	8
+NX_P83110	Serine protease HTRA3	453	48608	6.71	0	Cytoplasmic vesicle;Secreted	NA	Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).	NA	Belongs to the peptidase S1C family.	NA	PE1	4
+NX_P83111	Serine beta-lactamase-like protein LACTB, mitochondrial	547	60694	8.71	0	Mitochondrion	NA	Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758).	NA	Belongs to the peptidase S12 family.	NA	PE1	15
+NX_P83369	U7 snRNA-associated Sm-like protein LSm11	360	39500	10.99	0	Nucleoplasm;Nucleus	NA	Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA.	Not methylated.	Belongs to the snRNP Sm proteins family.	SLBP independent Processing of Histone Pre-mRNAs;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	5
+NX_P83436	Conserved oligomeric Golgi complex subunit 7	770	86344	5.27	0	Golgi apparatus;Golgi apparatus membrane	Congenital disorder of glycosylation 2E	Required for normal Golgi function.	NA	Belongs to the COG7 family.	Intra-Golgi traffic;COPI-mediated anterograde transport;Retrograde transport at the Trans-Golgi-Network	PE1	16
+NX_P83731	60S ribosomal protein L24	157	17779	11.26	0	Endoplasmic reticulum;Cytoplasm;Cytosol	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL24 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	3
+NX_P83859	Orexigenic neuropeptide QRFP	136	14941	10.25	0	Secreted	NA	Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity).	NA	Belongs to the RFamide neuropeptide family.	G alpha (q) signalling events;Orexin and neuropeptides FF and QRFP bind to their respective receptors	PE2	9
+NX_P83876	Thioredoxin-like protein 4A	142	16786	5.53	0	Nucleoplasm;Cytosol;Nucleus membrane;Nucleus	Burn-McKeown syndrome	Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).	The disulfide bond seen in structures determined by X-ray crystallography (PubMed:10610776) and NMR (PubMed:12911302) is not essential for protein folding and function (PubMed:12911302 and PubMed:17467737).	Belongs to the DIM1 family.	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	18
+NX_P83881	60S ribosomal protein L36a	106	12441	10.59	0	Cytoplasm	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL42 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	X
+NX_P83916	Chromobox protein homolog 1	185	21418	4.85	0	Nucleoplasm;Nucleus	NA	Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.	Not phosphorylated.;Ubiquitinated.	NA	NA	PE1	17
+NX_P84022	Mothers against decapentaplegic homolog 3	425	48081	6.73	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	Loeys-Dietz syndrome 3;Colorectal cancer	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.	Poly-ADP-ribosylated by PARP1 and PARP2. ADP-ribosylation negatively regulates SMAD3 transcriptional responses during the course of TGF-beta signaling.;Acetylation in the nucleus by EP300 in the MH2 domain regulates positively its transcriptional activity and is enhanced by TGF-beta.;Phosphorylated on serine and threonine residues. Enhanced phosphorylation in the linker region on Thr-179, Ser-204 and Ser-208 on EGF and TGF-beta treatment. Ser-208 is the main site of MAPK-mediated phosphorylation. CDK-mediated phosphorylation occurs in a cell-cycle dependent manner and inhibits both the transcriptional activity and antiproliferative functions of SMAD3. This phosphorylation is inhibited by flavopiridol. Maximum phosphorylation at the G(1)/S junction. Also phosphorylated on serine residues in the C-terminal SXS motif by TGFBR1 and ACVR1. TGFBR1-mediated phosphorylation at these C-terminal sites is required for interaction with SMAD4, nuclear location and transactivational activity, and appears to be a prerequisite for the TGF-beta mediated phosphorylation in the linker region. Dephosphorylated in the C-terminal SXS motif by PPM1A. This dephosphorylation disrupts the interaction with SMAD4, promotes nuclear export and terminates TGF-beta-mediated signaling. Phosphorylation at Ser-418 by CSNK1G2/CK1 promotes ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Phosphorylated by PDPK1.;Ubiquitinated. Monoubiquitinated, leading to prevent DNA-binding (PubMed:21947082). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (PubMed:21947082). Ubiquitinated by RNF111, leading to its degradation: only SMAD3 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD3 and regulating its turnover (By similarity). Undergoes STUB1-mediated ubiquitination and degradation (PubMed:24613385).;SMAD3 is phosphorylated by ACVR1C;SMAD3 is phosphorylated by PDPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the dwarfin/SMAD family.	Cell cycle;Endocytosis;Wnt signaling pathway;TGF-beta signaling pathway;Adherens junction;Chagas disease (American trypanosomiasis);HTLV-I infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Chronic myeloid leukemia;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;Signaling by NODAL;Signaling by Activin;SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD4 MH2 Domain Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;Ub-specific processing proteases;RUNX3 regulates CDKN1A transcription;RUNX3 regulates BCL2L11 (BIM) transcription;Interleukin-37 signaling;NOTCH4 Intracellular Domain Regulates Transcription;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell cycle genes	PE1	15
+NX_P84074	Neuron-specific calcium-binding protein hippocalcin	193	22427	4.87	0	Membrane;Cytosol	Dystonia 2, torsion, autosomal recessive	Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity).	Myristoylation facilitates association with membranes.	Belongs to the recoverin family.	NA	PE1	1
+NX_P84077	ADP-ribosylation factor 1	181	20697	6.31	0	Golgi apparatus;Cell membrane;Synaptosome;trans-Golgi network membrane;Membrane;Postsynaptic density;Cytosol;Perinuclear region	Periventricular nodular heterotopia 8	(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.;GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).	Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3.	Belongs to the small GTPase superfamily. Arf family.	Vibrio cholerae infection;Legionellosis;MHC class II antigen presentation;Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Nef Mediated CD4 Down-regulation;Intra-Golgi traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;trans-Golgi Network Vesicle Budding	PE1	1
+NX_P84085	ADP-ribosylation factor 5	180	20530	6.3	0	Membrane;Golgi apparatus;trans-Golgi network membrane;Perinuclear region	NA	(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.;GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.	NA	Belongs to the small GTPase superfamily. Arf family.	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	7
+NX_P84090	Enhancer of rudimentary homolog	104	12259	5.62	0	Nucleoplasm;Cytosol;Nucleus	NA	May have a role in the cell cycle.	NA	Belongs to the E(R) family.	NA	PE1	14
+NX_P84095	Rho-related GTP-binding protein RhoG	191	21309	8.41	0	Cell membrane	NA	Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.	NA	Belongs to the small GTPase superfamily. Rho family.	Bacterial invasion of epithelial cells;Shigellosis;Salmonella infection;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;GPVI-mediated activation cascade;Rho GTPase cycle;RHO GTPases activate KTN1;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Neutrophil degranulation	PE1	11
+NX_P84098	60S ribosomal protein L19	196	23466	11.48	0	Cytosol;Nucleolus	NA	NA	Citrullinated by PADI4.	Belongs to the eukaryotic ribosomal protein eL19 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	17
+NX_P84101	Small EDRK-rich factor 2	59	6900	10.44	0	Nucleolus;Cytoplasm;Nucleoplasm;Nucleus	NA	Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (PubMed:20723760).	NA	Belongs to the SERF family.	NA	PE1	15
+NX_P84103	Serine/arginine-rich splicing factor 3	164	19330	11.64	0	Cytoplasm;Nucleoplasm;Nucleus speckle;Nucleus	NA	Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). RNA-binding is semi-sequence specific (PubMed:17036044).	Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain.;SRSF3 is phosphorylated by SRPK1 (Phosphoserine:PTM-0253);SRSF3 is phosphorylated by CLK4 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRSF3 is phosphorylated by CLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRSF3 is phosphorylated by SRPK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the splicing factor SR family.	Spliceosome;Herpes simplex infection;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	6
+NX_P84157	Matrix-remodeling-associated protein 7	204	21466	4.24	1	Membrane;Endoplasmic reticulum	NA	NA	NA	NA	NA	PE1	17
+NX_P84243	Histone H3.3	136	15328	11.27	0	Nucleoplasm;Nucleus;Chromosome	Glioma	Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.;Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.;Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes (PubMed:29211711). It gives a specific tag for epigenetic transcription activation (PubMed:29211711).;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.;Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.;Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac) (PubMed:30257210).;Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.;Ubiquitinated. Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).;Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.;Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.	Belongs to the histone H3 family.	Systemic lupus erythematosus;Systemic lupus erythematosus;Transcriptional regulation by small RNAs;Factors involved in megakaryocyte development and platelet production;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	17
+NX_P84550	SKI family transcriptional corepressor 1	965	99831	6.11	0	Nucleus	NA	Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling.	NA	Belongs to the SKI family.	NA	PE1	15
+NX_P84996	Protein ALEX	626	67948	11.55	0	Ruffle;Cell membrane	ACTH-independent macronodular adrenal hyperplasia 1;Pseudohypoparathyroidism 1B;Colorectal cancer;GNAS hyperfunction	May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame.	NA	Belongs to the ALEX family.	Calcium signaling pathway;Vascular smooth muscle contraction;Gap junction;Glutamatergic synapse;Dopaminergic synapse;Long-term depression;Taste transduction;GnRH signaling pathway;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Vasopressin-regulated water reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;Vibrio cholerae infection;Chagas disease (American trypanosomiasis);Amoebiasis;Dilated cardiomyopathy	PE1	20
+NX_P85037	Forkhead box protein K1	733	75457	9.41	0	Nucleolus;Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164).	Phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with YWHAE/14-3-3-epsilon and retention in the cytoplasm. In response to mTORC1 signaling, phosphorylation by GSK3 is prevented, leading to translocation to the nucleus.	NA	UCH proteinases	PE1	7
+NX_P85298	Rho GTPase-activating protein 8	464	53484	9.45	0	Nucleoplasm	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	NA	NA	Rho GTPase cycle	PE1	22
+NX_P85299	Proline-rich protein 5	388	42753	8.31	0	NA	NA	Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. MTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. MTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. MTORC2 promotes the serum-induced formation of stress-fibers or F-actin. MTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. MTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. MTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.	NA	Belongs to the PROTOR family.	PIP3 activates AKT signaling;VEGFR2 mediated vascular permeability;CD28 dependent PI3K/Akt signaling;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation	PE1	22
+NX_P86397	Hydroxyacyl-thioester dehydratase type 2, mitochondrial	168	18559	9.1	0	Mitochondrion;Nucleolus	NA	Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis.	NA	Belongs to the HTD2 family.	Fatty acyl-CoA biosynthesis	PE1	3
+NX_P86434	Putative uncharacterized protein ADORA2A-AS1	159	17238	6.18	0	NA	NA	NA	NA	NA	NA	PE5	22
+NX_P86452	Zinc finger BED domain-containing protein 6	979	109973	6.09	0	Nucleolus;Nucleus	NA	Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity).	NA	NA	NA	PE1	1
+NX_P86478	Proline-rich protein 20E	221	23262	5.85	0	NA	NA	NA	NA	Belongs to the PRR20 family.	NA	PE1	13
+NX_P86479	Proline-rich protein 20C	221	23262	5.85	0	NA	NA	NA	NA	Belongs to the PRR20 family.	NA	PE1	13
+NX_P86480	Proline-rich protein 20D	221	23262	5.85	0	NA	NA	NA	NA	Belongs to the PRR20 family.	NA	PE1	13
+NX_P86481	Proline-rich protein 20B	221	23262	5.85	0	NA	NA	NA	NA	Belongs to the PRR20 family.	NA	PE2	13
+NX_P86496	Proline-rich protein 20A	221	23262	5.85	0	NA	NA	NA	NA	Belongs to the PRR20 family.	NA	PE2	13
+NX_P86790	Vacuolar fusion protein CCZ1 homolog B	482	55866	6.07	0	Cytoplasmic vesicle;Lysosome membrane	NA	NA	NA	Belongs to the CCZ1 family.	RAB GEFs exchange GTP for GDP on RABs	PE1	7
+NX_P86791	Vacuolar fusion protein CCZ1 homolog	482	55866	6.07	0	Cytoplasmic vesicle;Lysosome membrane	NA	Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991).	NA	Belongs to the CCZ1 family.	RAB GEFs exchange GTP for GDP on RABs	PE1	7
+NX_P87889	Endogenous retrovirus group K member 10 Gag polyprotein	666	74139	8.95	0	Cell membrane	NA	The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).;Specific enzymatic cleavages may yield mature proteins.	Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.	NA	PE1	5
+NX_P98066	Tumor necrosis factor-inducible gene 6 protein	277	31203	6.3	0	NA	NA	Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.	NA	NA	Neutrophil degranulation	PE1	2
+NX_P98073	Enteropeptidase	1019	112935	4.89	1	Membrane;Nucleolus;Cell membrane	Enterokinase deficiency	Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.	The chains are derived from a single precursor that is cleaved by a trypsin-like protease.	Belongs to the peptidase S1 family.	NA	PE1	21
+NX_P98077	SHC-transforming protein 2	582	61916	6.29	0	Cytosol	NA	Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).	Phosphorylated on tyrosines by the Trk receptors.	NA	ErbB signaling pathway;Chemokine signaling pathway;VEGF signaling pathway;Focal adhesion;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Insulin signaling pathway;Bacterial invasion of epithelial cells;Glioma;Chronic myeloid leukemia;RAF/MAP kinase cascade;VEGFA-VEGFR2 Pathway;Signalling to RAS	PE1	19
+NX_P98082	Disabled homolog 2	770	82448	5.34	0	Cytoplasm;Cell membrane;Nucleolus;Clathrin-coated pit;Clathrin-coated vesicle membrane;Cytoplasmic vesicle	NA	Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.	Phosphorylated. Phosphorylation during mitosis is leading to membrane displacement (By similarity).	NA	Endocytosis;Gap junction degradation;Formation of annular gap junctions;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	5
+NX_P98088	Mucin-5AC	5654	585570	6.71	0	Secreted	NA	Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.	Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.;C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	11
+NX_P98095	Fibulin-2	1184	126573	4.73	0	Extracellular matrix;Cell membrane	NA	Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).	O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or Ser-348.	Belongs to the fibulin family.	Molecules associated with elastic fibres	PE1	3
+NX_P98153	Integral membrane protein DGCR2/IDD	550	60811	5.11	1	Membrane	NA	Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.	NA	NA	NA	PE1	22
+NX_P98155	Very low-density lipoprotein receptor	873	96098	4.62	1	Centriolar satellite;Clathrin-coated pit;Membrane;Cytoplasmic vesicle;Cytoskeleton	Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1	Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).	Ubiquitinated at Lys-839 by MYLIP leading to degradation.	NA	Reelin signalling pathway;VLDLR internalisation and degradation;VLDL clearance	PE1	9
+NX_P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	4391	468830	6.06	0	Nucleoplasm;Cytosol;Basement membrane;Cell membrane	Dyssegmental dysplasia Silverman-Handmaker type;Schwartz-Jampel syndrome	The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.;Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.;Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.	Proteolytic processing produces the C-terminal angiogenic peptide, endorepellin. This peptide can be further processed to produce the LG3 peptide.;N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Perlecan contains three heparan sulfate chains. The LG3 peptide contains at least three and up to five potential O-glycosylation sites but no N-glycosylation.	NA	ECM-receptor interaction;Degradation of the extracellular matrix;Retinoid metabolism and transport;HS-GAG biosynthesis;Amyloid fiber formation;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Integrin cell surface interactions;ECM proteoglycans;Non-integrin membrane-ECM interactions;Laminin interactions;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	1
+NX_P98161	Polycystin-1	4303	462529	6.28	11	Golgi apparatus;Endoplasmic reticulum;Cilium;Cell membrane	Polycystic kidney disease 1 with or without polycystic liver disease	Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Both PKD1 and PKD2 are required for channel activity (PubMed:27214281). Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.	After synthesis, undergoes cleavage between Leu-3048 and Thr-3049 in the GPS domain. Cleavage at the GPS domain occurs through a cis-autoproteolytic mechanism involving an ester-intermediate via N-O acyl rearrangement. This process takes place in the early secretory pathway, depends on initial N-glycosylation, and requires the REJ domain. There is evidence that cleavage at GPS domain is incomplete. Uncleaved and cleaved products may have different functions in vivo.	Belongs to the polycystin family.	VxPx cargo-targeting to cilium	PE1	16
+NX_P98164	Low-density lipoprotein receptor-related protein 2	4655	521958	4.89	1	Mitochondrion;Coated pit;Endosome lumen;Cytoplasmic vesicle;Apical cell membrane;Axon;Dendrite	Donnai-Barrow syndrome	Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity).	A fraction undergoes proteolytic cleavage of the extracellular domain at the cell membrane to generate a cytoplasmic tail fragment. This is internalized into the early endosome from where it trafficks in an LDLRAP1/ARH-dependent manner to the endocytic recycling compartment (ERC). In the ERC, it is further cleaved by gamma-secretase to release a fragment which translocates to the nucleus and mediates transcriptional repression.;N-glycosylation is required for ligand binding.	Belongs to the LDLR family.	Hedgehog signaling pathway;Retinoid metabolism and transport;Vitamin D (calciferol) metabolism;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	2
+NX_P98168	Zinc finger X-linked protein ZXDA	799	84771	7.35	0	Nucleus	NA	Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.	NA	Belongs to the ZXD family.	NA	PE1	X
+NX_P98169	Zinc finger X-linked protein ZXDB	803	84792	6.46	0	Nucleus	NA	Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.	NA	Belongs to the ZXD family.	NA	PE1	X
+NX_P98170	E3 ubiquitin-protein ligase XIAP	497	56685	6.22	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	Lymphoproliferative syndrome, X-linked, 2	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.	Phosphorylation by PKB/AKT protects XIAP against ubiquitination and protects the protein against proteasomal degradation.;S-Nitrosylation down-regulates its E3 ubiquitin-protein ligase activity.;Autoubiquitinated and degraded by the proteasome in apoptotic cells.	Belongs to the IAP family.	Ubiquitin mediated proteolysis;Apoptosis;Focal adhesion;NOD-like receptor signaling pathway;Toxoplasmosis;HTLV-I infection;Pathways in cancer;Small cell lung cancer;Deactivation of the beta-catenin transactivating complex;RIPK1-mediated regulated necrosis;Activation of caspases through apoptosome-mediated cleavage;Regulation of necroptotic cell death;SMAC (DIABLO) binds to IAPs;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Regulation of PTEN stability and activity;Regulation of PTEN localization;Regulation of the apoptosome activity;SMAC, XIAP-regulated apoptotic response	PE1	X
+NX_P98171	Rho GTPase-activating protein 4	946	105026	5.96	0	Cytoplasm;Nucleoplasm;Focal adhesion	NA	Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.	NA	NA	Rho GTPase cycle	PE1	X
+NX_P98172	Ephrin-B1	346	38007	9.1	1	Membrane raft;Nucleus;Cell membrane	Craniofrontonasal syndrome	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity).	Proteolytically processed. The ectodomain is cleaved, probably by a metalloprotease, to produce a membrane-tethered C-terminal fragment. This fragment is then further processed by the gamma-secretase complex to yield a soluble intracellular domain peptide which can translocate to the nucleus. The intracellular domain peptide is highly labile suggesting that it is targeted for degradation by the proteasome.;Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.	Belongs to the ephrin family.	Axon guidance;EPH-Ephrin signaling;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells	PE1	X
+NX_P98173	Protein FAM3A	230	25152	8.9	0	Endoplasmic reticulum;Nucleoplasm;Secreted;Nucleolus	NA	May act as a defensin against invading fungal microorganisms.	NA	Belongs to the FAM3 family.	NA	PE1	X
+NX_P98174	FYVE, RhoGEF and PH domain-containing protein 1	961	106561	6.14	0	Cytoplasm;Cell membrane;Lamellipodium;Ruffle;Cytosol;Cytoskeleton	Aarskog-Scott syndrome	Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.	NA	NA	Regulation of actin cytoskeleton;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	X
+NX_P98175	RNA-binding protein 10	930	103533	5.69	0	Nucleus speckle;Nucleus	TARP syndrome	May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233).	NA	NA	NA	PE1	X
+NX_P98177	Forkhead box protein O4	505	53684	5.13	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.	Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization. May be phosphorylated at multiple sites by NLK.;Acetylation by CREBBP/CBP, which is induced by peroxidase stress, inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity.;Monoubiquitinated; monoubiquitination is induced by oxidative stress and reduced by deacetylase inhibitors; results in its relocalization to the nucleus and its increased transcriptional activity. Deubiquitinated by USP7; deubiquitination is induced by oxidative stress; enhances its interaction with USP7 and consequently, deubiquitination; increases its translocation to the cytoplasm and inhibits its transcriptional activity. Hydrogene-peroxide-induced ubiquitination and USP7-mediated deubiquitination have no major effect on its protein stability.;FOXO4 is phosphorylated by NLK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;Ub-specific processing proteases;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell death genes;Regulation of localization of FOXO transcription factors;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes	PE1	X
+NX_P98179	RNA-binding protein 3	157	17170	8.86	0	Cytoplasm;Nucleoplasm;Dendrite;Nucleus	NA	Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity).	Arg-105 is dimethylated, probably to asymmetric dimethylarginine.;Phosphorylated.	NA	NA	PE1	X
+NX_P98182	Zinc finger protein 200	395	45534	8.64	0	Mitochondrion;Nucleus	NA	Could have a role in spermatogenesis.	NA	NA	Generic Transcription Pathway	PE1	16
+NX_P98187	Cytochrome P450 4F8	520	59995	8.73	1	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions (PubMed:10791960, PubMed:16112640, PubMed:15789615). Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predominantly at omega-2 position to form (18R)-hydroxyeicosatetraenoic acid (18R-HETE) (PubMed:10791960). Exhibits omega-1 hydroxylase activity toward prostaglandin (PG) H1, PGH2 and PGI2 (PubMed:10791960, PubMed:15789615). Catalyzes the epoxidation of double bonds of PUFAs, including docosahexaenoic and docosapentaenoic acids (PubMed:16112640). Shows little activity against PGD2, PGE1, PGE2, PGF2alpha, and leukotriene B4.	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; fatty acid metabolism.;Fatty acids;Eicosanoids;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	19
+NX_P98194	Calcium-transporting ATPase type 2C member 1	919	100577	6.34	10	Golgi apparatus;Golgi apparatus membrane	Hailey-Hailey disease	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.	Ion transport by P-type ATPases	PE1	3
+NX_P98196	Probable phospholipid-transporting ATPase IH	1134	129756	6.17	10	Cell membrane;Recycling endosome;Early endosome;Endoplasmic reticulum;Cytoplasmic vesicle	NA	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases;Neutrophil degranulation	PE1	13
+NX_P98198	Phospholipid-transporting ATPase ID	1209	137440	6.57	10	Endoplasmic reticulum membrane;Cell membrane	NA	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases	PE1	1
+NX_P99999	Cytochrome c	105	11749	9.59	0	Mitochondrion intermembrane space;Mitochondrion;Nucleus	Thrombocytopenia 4	Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.;Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Binds 1 heme group per subunit.;Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.	Belongs to the cytochrome c family.	p53 signaling pathway;Apoptosis;Alzheimer's disease;Parkinson's disease;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Legionellosis;Toxoplasmosis;Tuberculosis;Influenza A;Herpes simplex infection;Pathways in cancer;Colorectal cancer;Small cell lung cancer;Viral myocarditis;Detoxification of Reactive Oxygen Species;Respiratory electron transport;Transcriptional activation of mitochondrial biogenesis;TP53 Regulates Metabolic Genes;Formation of apoptosome;Activation of caspases through apoptosome-mediated cleavage;Release of apoptotic factors from the mitochondria;SMAC (DIABLO) binds to IAPs;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes;Regulation of the apoptosome activity	PE1	7
+NX_Q00005	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform	443	51710	6.01	0	Mitochondrion outer membrane;Cytoplasm;Mitochondrion;Membrane;Cytoskeleton	Spinocerebellar ataxia 12	Regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity).;The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity).	NA	Belongs to the phosphatase 2A regulatory subunit B family.	mRNA surveillance pathway;Tight junction;Dopaminergic synapse;Chagas disease (American trypanosomiasis);Hepatitis C	PE1	5
+NX_Q00013	55 kDa erythrocyte membrane protein	466	52296	6.91	0	Cytoplasm;Cell membrane;Centriolar satellite;Stereocilium;Nucleus	NA	Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).	Palmitoylated.	Belongs to the MAGUK family.	NA	PE1	X
+NX_Q00056	Homeobox protein Hox-A4	320	34499	9.95	0	Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.	NA	Belongs to the Antp homeobox family. Deformed subfamily.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	7
+NX_Q00059	Transcription factor A, mitochondrial	246	29097	9.74	0	Mitochondrion;Mitochondrion nucleoid	Mitochondrial DNA depletion syndrome 15, hepatocerebral type	Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.	Phosphorylation by PKA within the HMG box 1 impairs DNA binding and promotes degradation by the AAA+ Lon protease.	NA	Huntington's disease;Transcriptional activation of mitochondrial biogenesis;Mitochondrial transcription initiation	PE1	10
+NX_Q00169	Phosphatidylinositol transfer protein alpha isoform	270	31806	6.12	0	Cytoplasm	NA	Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.	NA	Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.	Role of second messengers in netrin-1 signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	17
+NX_Q00266	S-adenosylmethionine synthase isoform type-1	395	43648	5.86	0	NA	Methionine adenosyltransferase deficiency	Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.	An intrachain disulfide bond can be formed. The protein structure shows that the relevant Cys residues are in a position that would permit formation of a disulfide bond.;S-nitrosylation of Cys-120 inactivates the enzyme.	Belongs to the AdoMet synthase family.	Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.;Cysteine and methionine metabolism;Metabolic pathways;Methylation;Sulfur amino acid metabolism;Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD);Metabolism of ingested SeMet, Sec, MeSec into H2Se	PE1	10
+NX_Q00325	Phosphate carrier protein, mitochondrial	362	40095	9.45	6	Mitochondrion inner membrane;Mitochondrion	Mitochondrial phosphate carrier deficiency	Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	12
+NX_Q00341	Vigilin	1268	141456	6.43	0	Cytoplasm;Cytosol;Nucleus	NA	Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.	NA	NA	HDL clearance	PE1	2
+NX_Q00403	Transcription initiation factor IIB	316	34833	8.67	0	Nucleoplasm;Nucleus;Chromosome	NA	General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:1876184, PubMed:1946368, PubMed:1517211, PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:7601352, PubMed:9420329, PubMed:12931194, PubMed:27193682). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8504927, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:9420329, PubMed:16230532, PubMed:7675079, PubMed:10619841). Modulates transcription start site selection (PubMed:10318856). Exhibits also autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194).	Acetylated (PubMed:24441171). Autoacetylated; autoacetylation at Lys-238 stimulates transcription activation (PubMed:12931194).	Belongs to the TFIIB family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA polymerase II transcribes snRNA genes	PE1	1
+NX_Q00444	Homeobox protein Hox-C5	222	24976	9.57	0	Nucleoplasm;Cell junction;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Antp homeobox family.	NA	PE1	12
+NX_Q00526	Cyclin-dependent kinase 3	305	35046	8.86	0	Cytosol	NA	Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	17
+NX_Q00532	Cyclin-dependent kinase-like 1	358	41803	9.04	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	14
+NX_Q00534	Cyclin-dependent kinase 6	326	36938	6.02	0	Cytoplasm;Nucleoplasm;Centrosome;Ruffle;Cytosol;Nucleus	Microcephaly 12, primary, autosomal recessive	Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. Erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).	Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Cell cycle;p53 signaling pathway;Measles;Pathways in cancer;Pancreatic cancer;Glioma;Melanoma;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Cyclin D associated events in G1;Regulation of RUNX1 Expression and Activity;Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6;Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	PE1	7
+NX_Q00535	Cyclin-dependent-like kinase 5	292	33304	7.57	0	Cytoplasm;Cell membrane;Growth cone;Perikaryon;Nucleoplasm;Lamellipodium;Postsynaptic density;Nucleus	Lissencephaly 7, with cerebellar hypoplasia	Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.	Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity.;Phosphorylation at Ser-159 is essential for maximal catalytic activity.;CDK5 is phosphorylated by CDK7	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Axon guidance;Alzheimer's disease;Factors involved in megakaryocyte development and platelet production;DARPP-32 events;CRMPs in Sema3A signaling;Regulation of TP53 Activity through Phosphorylation;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Activated NTRK2 signals through CDK5	PE1	7
+NX_Q00536	Cyclin-dependent kinase 16	496	55716	7.23	0	Cytoplasm;Synaptosome;Cell membrane;Cytosol;Secretory vesicle;Cytoskeleton	NA	Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).	Phosphorylation at Ser-153 inhibits kinase activity.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	X
+NX_Q00537	Cyclin-dependent kinase 17	523	59582	9.1	0	Nucleoplasm;Cytosol	NA	May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	12
+NX_Q00577	Transcriptional activator protein Pur-alpha	322	34911	6.07	0	Nucleus	Mental retardation, autosomal dominant 31	This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.	NA	Belongs to the PUR DNA-binding protein family.	NA	PE1	5
+NX_Q00587	Cdc42 effector protein 1	391	40295	6.64	0	Endomembrane system;Cytoskeleton;Cell membrane	NA	Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts.	NA	Belongs to the BORG/CEP family.	NA	PE1	22
+NX_Q00597	Fanconi anemia group C protein	558	63429	5.77	0	Cytoplasm;Nucleoplasm;Nucleus	Fanconi anemia complementation group C	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	NA	NA	Fanconi anemia pathway;Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes	PE1	9
+NX_Q00604	Norrin	133	15044	9.17	0	Cytoplasmic vesicle;Nucleoplasm;Secreted;Nucleolus	Vitreoretinopathy, exudative 2;Norrie disease	Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.	NA	NA	NA	PE1	X
+NX_Q00610	Clathrin heavy chain 1	1675	191615	5.48	0	Coated pit;Cytoplasmic vesicle membrane;Endosome;Melanosome;Lysosome;Cytoplasmic vesicle;Cytosol;Spindle	Mental retardation, autosomal dominant 56	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872).	NA	Belongs to the clathrin heavy chain family.	Lysosome;Endocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Huntington's disease;Bacterial invasion of epithelial cells;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Golgi Associated Vesicle Biogenesis;Retrograde neurotrophin signalling;Lysosome Vesicle Biogenesis;Recycling pathway of L1;Gap junction degradation;WNT5A-dependent internalization of FZD4;Formation of annular gap junctions;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;Entry of Influenza Virion into Host Cell via Endocytosis;LDL clearance	PE1	17
+NX_Q00613	Heat shock factor protein 1	529	57260	5.02	0	Kinetochore;Cytoplasm;Nucleoplasm;Spindle pole;Centrosome;Cytosol;Perinuclear region;Nucleus	NA	(Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300.;Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:1871105, PubMed:11447121, PubMed:1986252, PubMed:7760831, PubMed:7623826, PubMed:8946918, PubMed:8940068, PubMed:9341107, PubMed:9121459, PubMed:9727490, PubMed:9499401, PubMed:9535852, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:25963659, PubMed:26754925). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:9727490, PubMed:11583998, PubMed:16278218). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:1871105, PubMed:1986252, PubMed:8455624, PubMed:7935471, PubMed:7623826, PubMed:8940068, PubMed:9727490, PubMed:9499401, PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:25963659, PubMed:26754925). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925).	Acetylated on Lys-118; this acetylation is decreased in a IER5-dependent manner (PubMed:26754925). Acetylated on Lys-118, Lys-208 and Lys-298; these acetylations occur in a EP300-dependent manner (PubMed:24581496, PubMed:27189267). Acetylated on Lys-80; this acetylation inhibits DNA-binding activity upon heat shock (PubMed:19229036). Deacetylated on Lys-80 by SIRT1; this deacetylation increases DNA-binding activity (PubMed:19229036).;Ubiquitinated by SCF(BTRC) and degraded following stimulus-dependent phosphorylation at Ser-216 by PLK1 in mitosis (PubMed:18794143). Polyubiquitinated (PubMed:24581496). Undergoes proteasomal degradation upon heat shock and during the attenuation and recovery phase period of the heat shock response (PubMed:24581496).;Sumoylated with SUMO1 and SUMO2 upon heat shock in a ERK2-dependent manner (PubMed:12646186, PubMed:12665592). Sumoylated by SUMO1 on Lys-298; sumoylation occurs upon heat shock and promotes its localization to nuclear stress bodies and DNA-binding activity (PubMed:11514557). Phosphorylation on Ser-303 and Ser-307 is probably a prerequisite for sumoylation (PubMed:12646186, PubMed:12665592).;Phosphorylated (PubMed:9499401, PubMed:10359787, PubMed:11583998, PubMed:26159920). Phosphorylated in unstressed cells; this phosphorylation is constitutive and implicated in the repression of HSF1 transcriptional activity (PubMed:8946918, PubMed:8940068, PubMed:9121459, PubMed:16278218). Phosphorylated on Ser-121 by MAPKAPK2; this phosphorylation promotes interaction with HSP90 proteins and inhibits HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Phosphorylation on Ser-303 by GSK3B/GSK3-beta and on Ser-307 by MAPK3 within the regulatory domain is involved in the repression of HSF1 transcriptional activity and occurs in a RAF1-dependent manner (PubMed:8946918, PubMed:8940068, PubMed:9121459, PubMed:9535852, PubMed:10747973, PubMed:12646186). Phosphorylation on Ser-303 and Ser-307 increases HSF1 nuclear export in a YWHAE- and XPO1/CRM1-dependent manner (PubMed:12917326). Phosphorylation on Ser-307 is a prerequisite for phosphorylation on Ser-303 (PubMed:8940068). According to PubMed:9535852, Ser-303 is not phosphorylated in unstressed cells. Phosphorylated on Ser-419 by PLK1; phosphorylation promotes nuclear translocation upon heat shock (PubMed:15661742). Hyperphosphorylated upon heat shock and during the attenuation and recovery phase period of the heat shock response (PubMed:11447121, PubMed:12659875, PubMed:24581496). Phosphorylated on Thr-142; this phosphorylation increases HSF1 transactivation activity upon heat shock (PubMed:12659875). Phosphorylation on Ser-230 by CAMK2A; this phosphorylation enhances HSF1 transactivation activity upon heat shock (PubMed:11447121). Phosphorylation on Ser-326 by MAPK12; this phosphorylation enhances HSF1 nuclear translocation, homotrimerization and transactivation activities upon heat shock (PubMed:15760475, PubMed:27354066). Phosphorylated on Ser-320 by PRKACA/PKA; this phosphorylation promotes nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Phosphorylated on Ser-363 by MAPK8; this phosphorylation occurs upon heat shock, induces HSF1 translocation into nuclear stress bodies and negatively regulates transactivation activity (PubMed:10747973). Neither basal nor stress-inducible phosphorylation on Ser-230, Ser-292, Ser-303, Ser-307, Ser-314, Ser-319, Ser-320, Thr-323, Ser-326, Ser-338, Ser-344, Ser-363, Thr-367, Ser-368 and Thr-369 within the regulatory domain is involved in the regulation of HSF1 subcellular localization or DNA-binding activity; however, it negatively regulates HSF1 transactivation activity (PubMed:25963659). Phosphorylated on Ser-216 by PLK1 in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex inducing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Dephosphorylated on Ser-121, Ser-307, Ser-314, Thr-323 and Thr-367 by phosphatase PPP2CA in an IER5-dependent manner, leading to HSF1-mediated transactivation activity (PubMed:26754925).;HSF1 is phosphorylated by PRKCQ (Phosphoserine:PTM-0253)	Belongs to the HSF family.	Legionellosis;Regulation of HSF1-mediated heat shock response;Attenuation phase;HSF1-dependent transactivation;HSF1 activation	PE1	8
+NX_Q00653	Nuclear factor NF-kappa-B p100 subunit	900	96749	5.84	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	Immunodeficiency, common variable, 10	Is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.;NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. P52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. P52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor.	Constitutive processing is tightly suppressed by its C-terminal processing inhibitory domain, named PID, which contains the death domain.;While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p52 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.;Subsequent to MAP3K14-dependent serine phosphorylation, p100 polyubiquitination occurs then triggering its proteasome-dependent processing.	NA	MAPK signaling pathway;Osteoclast differentiation;Legionellosis;HTLV-I infection;Pathways in cancer;Dectin-1 mediated noncanonical NF-kB signaling;NIK-->noncanonical NF-kB signaling;PKMTs methylate histone lysines;The NLRP3 inflammasome;RIP-mediated NFkB activation via ZBP1;DEx/H-box helicases activate type I IFN and inflammatory cytokines production;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;IkBA variant leads to EDA-ID;Interleukin-1 processing;SUMOylation of immune response proteins	PE1	10
+NX_Q00688	Peptidyl-prolyl cis-trans isomerase FKBP3	224	25177	9.29	0	Cytosol;Nucleus	NA	FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.	NA	Belongs to the FKBP-type PPIase family.	NA	PE1	14
+NX_Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	1185	134024	5.96	0	Cytosol	NA	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;Vascular smooth muscle contraction;Wnt signaling pathway;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;Dopaminergic synapse;Long-term depression;Taste transduction;GnRH signaling pathway;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Alzheimer's disease;Huntington's disease;Chagas disease (American trypanosomiasis);African trypanosomiasis;Amoebiasis;G alpha (q) signalling events;Ca2+ pathway;G beta:gamma signalling through PLC beta;Presynaptic function of Kainate receptors;Synthesis of IP3 and IP4 in the cytosol;PLC beta mediated events;Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion;Acetylcholine regulates insulin secretion	PE1	15
+NX_Q00765	Receptor expression-enhancing protein 5	189	21493	8.25	2	Membrane;Endoplasmic reticulum	NA	May promote functional cell surface expression of olfactory receptors.	NA	Belongs to the DP1 family.	Olfactory Signaling Pathway	PE1	5
+NX_Q00796	Sorbitol dehydrogenase	357	38325	8.23	0	Mitochondrion membrane;Cytosol;Flagellum	NA	Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively (PubMed:3365415). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia (PubMed:12962626, PubMed:29966615, PubMed:25105142). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (PubMed:16278369). May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor (PubMed:3365415).	NA	Belongs to the zinc-containing alcohol dehydrogenase family.	Fructose and mannose metabolism;Metabolic pathways;Fructose biosynthesis;Formation of xylulose-5-phosphate	PE1	15
+NX_Q00839	Heterogeneous nuclear ribonucleoprotein U	825	90584	5.76	0	Cytoplasm;Nucleus speckle;Nucleus matrix;Chromosome;Cell surface;Midbody;Spindle pole;Nucleoplasm;Centrosome;Nucleus;Spindle;Cytoplasmic granule;Kinetochore	Epileptic encephalopathy, early infantile, 54	DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:8174554, PubMed:28622508). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:8174554, PubMed:9353307, PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Contributes also to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:7509195, PubMed:1324173, PubMed:9204873, PubMed:9405365, PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:28622508). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity).;(Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm.	Citrullinated by PADI4.;Arg-739 is dimethylated, probably to asymmetric dimethylarginine (Ref.8). Arg-733 is dimethylated, probably to asymmetric dimethylarginine (By similarity).;Cleaved at Asp-100 by CASP3 during T-cell apoptosis, resulting in a loss of DNA- and chromatin-binding activities (PubMed:9405365, PubMed:10671544).;Extensively phosphorylated (PubMed:7993898). Phosphorylated on Ser-59 by PLK1 and dephosphorylated by protein phosphatase 2A (PP2A) in mitosis (PubMed:25986610).	NA	Spliceosome;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA	PE1	1
+NX_Q00872	Myosin-binding protein C, slow-type	1141	128294	5.78	0	Cytoplasm	Arthrogryposis, distal, 1B;Lethal congenital contracture syndrome 4	Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.	NA	Belongs to the immunoglobulin superfamily. MyBP family.	Striated Muscle Contraction	PE1	12
+NX_Q00887	Pregnancy-specific beta-1-glycoprotein 9	426	48272	8.27	0	Secreted	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall	PE1	19
+NX_Q00888	Pregnancy-specific beta-1-glycoprotein 4	419	47113	9.34	0	Secreted	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall	PE1	19
+NX_Q00889	Pregnancy-specific beta-1-glycoprotein 6	435	48814	8.86	0	Secreted	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall	PE1	19
+NX_Q008S8	Epithelial cell-transforming sequence 2 oncogene-like	904	104880	8.65	0	NA	NA	May act as a guanine nucleotide exchange factor (GEF).	NA	NA	NA	PE1	6
+NX_Q00973	Beta-1,4 N-acetylgalactosaminyltransferase 1	533	58882	8.93	1	Golgi apparatus membrane	Spastic paraplegia 26, autosomal recessive	Involved in the biosynthesis of gangliosides GM2, GD2 and GA2.	NA	Belongs to the glycosyltransferase 2 family.	Sphingolipid metabolism.;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Glycosphingolipid metabolism	PE1	12
+NX_Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	2339	262496	8.78	24	Membrane	NA	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.	Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK.	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily.	MAPK signaling pathway;Calcium signaling pathway;Synaptic vesicle cycle;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Taste transduction;Type II diabetes mellitus;Presynaptic depolarization and calcium channel opening	PE1	9
+NX_Q00978	Interferon regulatory factor 9	393	43696	5.58	0	Cytoplasm;Cytosol;Nucleus	NA	Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.	NA	Belongs to the IRF family.	Osteoclast differentiation;Jak-STAT signaling pathway;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Interferon gamma signaling;Interferon alpha/beta signaling	PE1	14
+NX_Q00987	E3 ubiquitin-protein ligase Mdm2	491	55233	4.6	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity).	Phosphorylation on Ser-166 by SGK1 activates ubiquitination of p53/TP53. Phosphorylated at multiple sites near the RING domain by ATM upon DNA damage; this prevents oligomerization and E3 ligase processivity and impedes constitutive p53/TP53 degradation.;Autoubiquitination leads to proteasomal degradation; resulting in p53/TP53 activation it may be regulated by SFN. Also ubiquitinated by TRIM13. Deubiquitinated by USP2 leads to its accumulation and increases deubiquitination and degradation of p53/TP53. Deubiquitinated by USP7 leading to its stabilization.;MDM2 is phosphorylated by HIPK2	Belongs to the MDM2/MDM4 family.	Cell cycle;p53 signaling pathway;Ubiquitin mediated proteolysis;Endocytosis;Pathways in cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Oxidative Stress Induced Senescence;Oncogene Induced Senescence;Trafficking of AMPA receptors;Constitutive Signaling by AKT1 E17K in Cancer;AKT phosphorylates targets in the cytosol;Stabilization of p53;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;SUMOylation of transcription factors;Ub-specific processing proteases;Regulation of RUNX3 expression and activity;SUMOylation of ubiquitinylation proteins	PE1	12
+NX_Q00994	Protein BEX3	111	12958	5.31	0	Cytoplasm;Cytosol;Nucleus	NA	May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.	Ubiquitinated. Degraded by the proteasome (By similarity).	Belongs to the BEX family.	Neurotrophin signaling pathway;NADE modulates death signalling	PE1	X
+NX_Q00G26	Perilipin-5	463	50791	5.08	0	Cytoplasmic vesicle;Cytoplasm;Mitochondrion;Lipid droplet	NA	Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity).	Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation (By similarity).	Belongs to the perilipin family.	NA	PE1	19
+NX_Q00LT1	Photoreceptor disk component PRCD	54	6007	7.96	0	Endoplasmic reticulum;Golgi apparatus;Photoreceptor outer segment;Membrane	Retinitis pigmentosa 36	Involved in vision.	Phosphorylated.;Palmitoylated at Cys-2 (PubMed:27613864). Palmitoylation is essential for protein stability and trafficking to the photoreceptor outer segment, but does not appear to be essential for membrane localization (PubMed:27613864). Probably palmitoylated by ZDHHC3 (PubMed:27613864).	Belongs to the PRCD family.	NA	PE1	17
+NX_Q01064	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	536	61380	5.33	0	Cytoplasm	NA	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.	Purine metabolism;Calcium signaling pathway;G alpha (s) signalling events;cGMP effects;Cam-PDE 1 activation	PE1	12
+NX_Q01081	Splicing factor U2AF 35 kDa subunit	240	27872	9.09	0	Nucleoplasm;Nucleus speckle;Nucleus	Myelodysplastic syndrome	Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.	NA	Belongs to the splicing factor SR family.	Spliceosome;Shigellosis;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	21
+NX_Q01082	Spectrin beta chain, non-erythrocytic 1	2364	274609	5.39	0	Golgi apparatus;Cytoplasm;Cell membrane;M line;Cytoskeleton	NA	Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.	SPTBN1 is phosphorylated by MAPK3	Belongs to the spectrin family.	RAF/MAP kinase cascade;Interaction between L1 and Ankyrins;Nephrin family interactions;NCAM signaling for neurite out-growth;COPI-mediated anterograde transport	PE1	2
+NX_Q01085	Nucleolysin TIAR	375	41591	7.62	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytoplasmic granule;Nucleus	NA	RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.	Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.;TIAL1 is phosphorylated by MAPK14 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	FGFR2 alternative splicing	PE1	10
+NX_Q01094	Transcription factor E2F1	437	46920	4.79	0	Nucleoplasm;Centrosome;Nucleus	NA	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599).	Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis.;Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation. Acetylated by P/CAF/KAT2B.	Belongs to the E2F/DP family.	Cell cycle;HTLV-I infection;Pathways in cancer;Pancreatic cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Oxidative Stress Induced Senescence;CDC6 association with the ORC:origin complex;G1/S-Specific Transcription;Pre-NOTCH Transcription and Translation;Cyclin E associated events during G1/S transition;Oncogene Induced Senescence;Cyclin A:Cdk2-associated events at S phase entry;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Cyclin D associated events in G1;G2 Phase;Activation of PUMA and translocation to mitochondria;Activation of NOXA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;Transcriptional Regulation by E2F6;Transcriptional regulation of granulopoiesis	PE1	20
+NX_Q01101	Insulinoma-associated protein 1	510	52923	9.19	0	Nucleus	NA	Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (PubMed:23721412). Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation.	NA	Belongs to the INSM1 family.	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	PE1	20
+NX_Q01105	Protein SET	290	33489	4.23	0	Endoplasmic reticulum;Nucleoplasm;Nucleus;Cytosol	Mental retardation, autosomal dominant 58	Inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.;Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning.;Are potent inhibitors of protein phosphatase 2A.;Anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition.	Is phosphorylated on Ser-15 and Ser-24.;Cleaved after Lys-176 by GZMA. The cleavage inhibits its nucleosome assembly activity and disrupts the inhibition on NME1.;Is acetylated on Lys-11.;Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).;N-terminus of isoform 1 is methylated by METTL11A/NTM1. Mainly trimethylated (By similarity).	Belongs to the nucleosome assembly protein (NAP) family.	Condensation of Prophase Chromosomes;HuR (ELAVL1) binds and stabilizes mRNA	PE1	9
+NX_Q01113	Interleukin-9 receptor	521	57147	5.27	1	Secreted;Cell membrane	NA	This is a receptor for interleukin-9.	NA	Belongs to the type I cytokine receptor family. Type 4 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Interleukin-9 signaling	PE1	X
+NX_Q01118	Sodium channel protein type 7 subunit alpha	1682	193493	8.26	24	Cell membrane	NA	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 656) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.	Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	2
+NX_Q01130	Serine/arginine-rich splicing factor 2	221	25476	11.86	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.	Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6, which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation.;Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation.;SRSF2 is phosphorylated by SRPK1 (Phosphoserine:PTM-0253);SRSF2 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRSF2 is phosphorylated by SRPK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the splicing factor SR family.	Spliceosome;Herpes simplex infection;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	17
+NX_Q01151	CD83 antigen	205	23042	8.45	1	Membrane	NA	May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.	NA	NA	NA	PE1	6
+NX_Q01167	Forkhead box protein K2	660	69062	9.56	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027).	Hyperphosphorylated during mitosis by CDK1 and, to a lower extent, CDK2 (PubMed:20810654). Phosphorylation at Ser-373 and Ser-428 affects stability by promoting degradation (PubMed:20810654).	NA	UCH proteinases	PE1	17
+NX_Q01196	Runt-related transcription factor 1	453	48737	9.4	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	Familial platelet disorder with associated myeloid malignancy	Shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation.;Interferes with the transactivation activity of RUNX1.;Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity).	Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with KAT6A.;Methylated.;Phosphorylated in Ser-249 Thr-273 and Ser-276 by HIPK2 when associated with CBFB and DNA. This phosphorylation promotes subsequent EP300 phosphorylation.;RUNX1 is phosphorylated by HIPK1	NA	Pathways in cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Pre-NOTCH Transcription and Translation;Organic cation transport;RUNX3 regulates p14-ARF;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of RUNX1 Expression and Activity;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;RUNX1 regulates estrogen receptor mediated transcription;RUNX1 regulates transcription of genes involved in WNT signaling;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes;RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs);RUNX1 regulates transcription of genes involved in BCR signaling;RUNX2 regulates genes involved in differentiation of myeloid cells;RUNX1 regulates expression of components of tight junctions;RUNX1 regulates transcription of genes involved in interleukin signaling;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	21
+NX_Q01201	Transcription factor RelB	579	62134	5.84	0	Nucleoplasm;Cytosol;Centrosome;Nucleus	Immunodeficiency 53	NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063).	Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation.	NA	MAPK signaling pathway;Osteoclast differentiation;HTLV-I infection;Dectin-1 mediated noncanonical NF-kB signaling;NIK-->noncanonical NF-kB signaling;CD209 (DC-SIGN) signaling	PE1	19
+NX_Q01344	Interleukin-5 receptor subunit alpha	420	47685	5.36	1	Membrane	NA	This is the receptor for interleukin-5. The alpha chain binds to IL5.	NA	Belongs to the type I cytokine receptor family. Type 5 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;RAF/MAP kinase cascade;Interleukin receptor SHC signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling	PE1	3
+NX_Q01362	High affinity immunoglobulin epsilon receptor subunit beta	244	26534	5.05	4	Membrane	NA	High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.	Phosphorylated on tyrosine residues by LYN.	Belongs to the MS4A family.	Fc epsilon RI signaling pathway;Asthma;FCERI mediated NF-kB activation;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;Fc epsilon receptor (FCERI) signaling	PE1	11
+NX_Q01415	N-acetylgalactosamine kinase	458	50378	6.19	0	Nucleoplasm;Cytosol	NA	Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.	NA	Belongs to the GHMP kinase family. GalK subfamily.	Galactose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways	PE1	15
+NX_Q01432	AMP deaminase 3	767	88812	6.51	0	Nucleus membrane	Adenosine monophosphate deaminase deficiency erythrocyte type	AMP deaminase plays a critical role in energy metabolism.	NA	Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.;Purine metabolism;Metabolic pathways;Purine salvage;Neutrophil degranulation	PE1	11
+NX_Q01433	AMP deaminase 2	879	100688	6.46	0	Cytosol	Spastic paraplegia 63, autosomal recessive;Pontocerebellar hypoplasia 9	AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.	Methylated at Gln-6 by N6AMT1.	Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.;Purine metabolism;Metabolic pathways;Purine salvage	PE1	1
+NX_Q01449	Myosin regulatory light chain 2, atrial isoform	175	19448	4.83	0	NA	NA	NA	NA	NA	Focal adhesion;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Smooth Muscle Contraction	PE1	7
+NX_Q01453	Peripheral myelin protein 22	160	17891	7.75	4	Cell membrane	Dejerine-Sottas syndrome;Charcot-Marie-Tooth disease 1E;Hereditary neuropathy with liability to pressure palsies;Inflammatory demyelinating polyneuropathy;Charcot-Marie-Tooth disease 1A	Might be involved in growth regulation, and in myelinization in the peripheral nervous system.	NA	Belongs to the PMP-22/EMP/MP20 family.	NA	PE1	17
+NX_Q01459	Di-N-acetylchitobiase	385	43760	6.19	0	Cytosol;Lysosome	NA	Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.	NA	Belongs to the glycosyl hydrolase 18 family.	NA	PE1	1
+NX_Q01469	Fatty acid-binding protein 5	135	15164	6.6	0	Cytoplasm;Cell membrane;Secreted;Postsynaptic density;Synapse;Cytosol;Nucleus	NA	Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987).	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	PPAR signaling pathway;Triglyceride catabolism;Signaling by Retinoic Acid;Neutrophil degranulation	PE1	8
+NX_Q01484	Ankyrin-2	3957	433715	5.03	0	Mitochondrion;T-tubule;Cell membrane;Postsynaptic cell membrane;Recycling endosome;Early endosome;Membrane;Lysosome;Apical cell membrane;Z line;M line;Cytoskeleton	Long QT syndrome 4	Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).	Phosphorylated at multiple sites by different protein kinases and each phosphorylation event regulates the protein's structure and function.	NA	Interaction between L1 and Ankyrins;COPI-mediated anterograde transport	PE1	4
+NX_Q01518	Adenylyl cyclase-associated protein 1	475	51901	8.24	0	Cytosol;Cell membrane	NA	Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.	NA	Belongs to the CAP family.	Platelet degranulation;Role of ABL in ROBO-SLIT signaling;Neutrophil degranulation	PE1	1
+NX_Q01523	Defensin-5	94	10071	8.3	0	Cytoplasmic vesicle;Secretory vesicle;Secreted;Midbody	NA	Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.	Glycosylated.	Belongs to the alpha-defensin family.	Alpha-defensins;Defensins	PE1	8
+NX_Q01524	Defensin-6	100	10975	5.21	0	Secreted	NA	Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.	NA	Belongs to the alpha-defensin family.	Alpha-defensins;Defensins	PE1	8
+NX_Q01534	Testis-specific Y-encoded protein 1	308	35012	5.29	0	Cytoplasm;Nucleus	NA	May be involved in sperm differentiation and proliferation.	Phosphorylated.	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	Y
+NX_Q01538	Myelin transcription factor 1	1121	122329	4.81	0	Nucleoplasm;Cytosol;Nucleus	NA	Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.	NA	Belongs to the MYT1 family.	NA	PE1	20
+NX_Q01543	Friend leukemia integration 1 transcription factor	452	50982	6.57	0	Nucleoplasm;Nucleus	Bleeding disorder, platelet-type 21;Ewing sarcoma	Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.	NA	Belongs to the ETS family.	Transcriptional regulation of granulopoiesis	PE1	11
+NX_Q01546	Keratin, type II cytoskeletal 2 oral	638	65841	8.38	0	NA	NA	Probably contributes to terminal cornification.	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q01581	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	520	57294	5.22	0	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	NA	This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	NA	Belongs to the thiolase-like superfamily. HMG-CoA synthase family.	Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation;Butanoate metabolism;Terpenoid backbone biosynthesis;Metabolic pathways;PPARA activates gene expression;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	5
+NX_Q01628	Interferon-induced transmembrane protein 3	133	14632	6.49	1	Endosome;Lysosome membrane;Late endosome membrane;Cell membrane	NA	IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.	Not glycosylated.;Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.;Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiquitination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site.	Belongs to the CD225/Dispanin family.	Interferon alpha/beta signaling	PE1	11
+NX_Q01629	Interferon-induced transmembrane protein 2	132	14632	6.89	1	Cell membrane	NA	IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.	Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.	Belongs to the CD225/Dispanin family.	Interferon alpha/beta signaling	PE1	11
+NX_Q01638	Interleukin-1 receptor-like 1	556	63358	8.63	1	Cytosol;Focal adhesion;Secreted;Cell membrane	NA	Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.;Inhibits IL-33 signaling.	NA	Belongs to the interleukin-1 receptor family.	PIP3 activates AKT signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-33 signaling	PE1	2
+NX_Q01650	Large neutral amino acids transporter small subunit 1	507	55010	7.9	12	Cell membrane;Apical cell membrane;Lysosome membrane;Cytoplasmic vesicle;Cytosol	NA	The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744).	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.	Tryptophan catabolism;Amino acid transport across the plasma membrane;Basigin interactions	PE1	16
+NX_Q01658	Protein Dr1	176	19444	4.69	0	Nucleoplasm;Nucleus	NA	The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.	Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.	Belongs to the NC2 beta/DR1 family.	HATs acetylate histones	PE1	1
+NX_Q01664	Transcription factor AP-4	338	38726	5.63	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.	NA	NA	NA	PE1	16
+NX_Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	2161	245141	6.32	24	Membrane;Nucleus membrane	Primary aldosteronism, seizures, and neurologic abnormalities;Sinoatrial node dysfunction and deafness	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines.	NA	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.	MAPK signaling pathway;Calcium signaling pathway;Cardiac muscle contraction;Vascular smooth muscle contraction;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;GnRH signaling pathway;Type II diabetes mellitus;Carbohydrate digestion and absorption;Alzheimer's disease;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;NCAM1 interactions;Adrenaline,noradrenaline inhibits insulin secretion;Regulation of insulin secretion;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	3
+NX_Q01718	Adrenocorticotropic hormone receptor	297	33927	9.02	7	Cell membrane	Glucocorticoid deficiency 1	Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (s) signalling events;Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	PE1	18
+NX_Q01726	Melanocyte-stimulating hormone receptor	317	34706	8.78	7	Cell membrane	Melanoma, cutaneous malignant 5	Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Melanogenesis;Peptide ligand-binding receptors;G alpha (s) signalling events	PE1	16
+NX_Q01740	Dimethylaniline monooxygenase [N-oxide-forming] 1	532	60311	6.8	1	Microsome membrane;Endoplasmic reticulum membrane	NA	This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.	NA	Belongs to the FMO family.	Drug metabolism - cytochrome P450;FMO oxidises nucleophiles	PE1	1
+NX_Q01780	Exosome component 10	885	100831	8.68	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.	NA	NA	RNA degradation;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	1
+NX_Q01804	OTU domain-containing protein 4	1114	124045	6.25	0	Cytoplasm;Cytosol;Nucleus	NA	Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111).	Phosphorylated on Ser-202 and Ser-204 likely by CSNK2A1-CSNK2A2 serine/threonine-protein kinase complex. Activates 'Lys-63'-specific deubiquitinase activity.	NA	NA	PE1	4
+NX_Q01813	ATP-dependent 6-phosphofructokinase, platelet type	784	85596	7.5	0	Cytoplasm;Cytosol	NA	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.	GlcNAcylation decreases enzyme activity.	Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Fructose and mannose metabolism;Galactose metabolism;Metabolic pathways;Glycolysis	PE1	10
+NX_Q01814	Plasma membrane calcium-transporting ATPase 2	1243	136876	5.66	10	Synapse;Cell membrane	NA	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.	Calcium signaling pathway;Salivary secretion;Pancreatic secretion;Ion transport by P-type ATPases;Reduction of cytosolic Ca++ levels;Ion homeostasis	PE1	3
+NX_Q01826	DNA-binding protein SATB1	763	85957	6.1	0	Nucleus;Nucleoplasm;Nucleus matrix;PML body	NA	Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity).	Sumoylated. Sumoylation promotes cleavage by caspases.;Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation.;Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms cannot dimerize and lose transcription regulation function because of impaired DNA and chromatin association.	Belongs to the CUT homeobox family.	Apoptotic cleavage of cellular proteins;SUMOylation of chromatin organization proteins	PE1	3
+NX_Q01831	DNA repair protein complementing XP-C cells	940	105953	9.03	0	Nucleoplasm;Cytoplasm;Nucleus;Cell membrane	Xeroderma pigmentosum complementation group C	Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity.;The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.	Sumoylated; sumoylation promotes ubiquitination by RNF111.;Ubiquitinated upon UV irradiation; the ubiquitination requires the UV-DDB complex, appears to be reversible and does not serve as a signal for degradation (PubMed:15882621, PubMed:23751493). Ubiquitinated by RNF11 via 'Lys-63'-linked ubiquitination (PubMed:23751493). Ubiquitination by RNF111 is polysumoylation-dependent and promotes nucleotide excision repair (PubMed:23751493).	Belongs to the XPC family.	SUMOylation of DNA damage response and repair proteins;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER	PE1	3
+NX_Q01844	RNA-binding protein EWS	656	68478	9.37	0	Cytoplasm;Cell membrane;Nucleolus;Nucleoplasm;Nucleus	Ewing sarcoma;Angiomatoid fibrous histiocytoma	Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	Phosphorylated; calmodulin-binding inhibits phosphorylation of Ser-266.;Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8.	Belongs to the RRM TET family.	NA	PE1	22
+NX_Q01850	Cerebellar degeneration-related protein 2	454	51855	5.01	0	Nucleoplasm	NA	NA	NA	Belongs to the CDR2 family.	NA	PE1	16
+NX_Q01851	POU domain, class 4, transcription factor 1	419	42697	9.15	0	Cytoplasm;Nucleus	NA	Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have antiapoptotic effect on neuronal cells.;Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.	NA	Belongs to the POU transcription factor family. Class-4 subfamily.	Regulation of TP53 Activity through Association with Co-factors	PE1	13
+NX_Q01860	POU domain, class 5, transcription factor 1	360	38571	5.69	0	Cytoplasm;Nucleus	NA	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.	ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.;Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation.;Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression.	Belongs to the POU transcription factor family. Class-5 subfamily.	Transcriptional regulation of pluripotent stem cells;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	PE1	6
+NX_Q01892	Transcription factor Spi-B	262	28819	5.35	0	Cytoplasm;Nucleus	NA	Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.	NA	Belongs to the ETS family.	NA	PE1	19
+NX_Q01954	Zinc finger protein basonuclin-1	994	110972	7	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional activator (By similarity). Likely specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). May also play a role in the differentiation of oocytes and the early development of embryos (By similarity).	Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization.	NA	NA	PE1	15
+NX_Q01955	Collagen alpha-3(IV) chain	1670	161813	9.28	0	Endoplasmic reticulum;Cytoplasmic vesicle;Basement membrane	Alport syndrome 2, autosomal recessive;Alport syndrome 3, autosomal dominant;Hematuria, benign familial	Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.;Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.	Contains an additional N-linked glycosylation site.;Phosphorylated. Thought to be phosphorylated by CERT, but CERT does not have kinase activity.;The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.;Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.;Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.	Belongs to the type IV collagen family.	Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Non-integrin membrane-ECM interactions;Laminin interactions;Crosslinking of collagen fibrils;Anchoring fibril formation;Extracellular matrix organization;Collagen chain trimerization	PE1	2
+NX_Q01959	Sodium-dependent dopamine transporter	620	68495	6.46	12	Cytoplasmic vesicle;Cell membrane	Parkinsonism-dystonia infantile	Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.	SLC6A3 is phosphorylated by MAPK14 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SLC6A3 is phosphorylated by MAPK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SLC6A3 is phosphorylated by MAPK9 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.	Dopaminergic synapse;Parkinson's disease;Na+/Cl- dependent neurotransmitter transporters;Dopamine clearance from the synaptic cleft;Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS);Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	PE1	5
+NX_Q01968	Inositol polyphosphate 5-phosphatase OCRL	901	104205	6.13	0	trans-Golgi network;Phagosome membrane;Photoreceptor outer segment;Centriolar satellite;Cilium;Clathrin-coated pit;Endosome;Lysosome;Early endosome membrane;Cytoplasmic vesicle;Cytosol;Cytoskeleton	Dent disease 2;Lowe oculocerebrorenal syndrome	Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:7761412, PubMed:15474001, PubMed:9430698, PubMed:10764818). Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:7761412, PubMed:25869668). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788).	NA	Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane;Rho GTPase cycle;Golgi Associated Vesicle Biogenesis;Synthesis of IP2, IP, and Ins in the cytosol;Synthesis of IP3 and IP4 in the cytosol;Clathrin-mediated endocytosis	PE1	X
+NX_Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	1234	138799	5.68	0	Membrane;Nucleoplasm	NA	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;Vascular smooth muscle contraction;Wnt signaling pathway;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;Dopaminergic synapse;Long-term depression;GnRH signaling pathway;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Alzheimer's disease;Huntington's disease;Chagas disease (American trypanosomiasis);African trypanosomiasis;Amoebiasis;G alpha (q) signalling events;Ca2+ pathway;G beta:gamma signalling through PLC beta;Presynaptic function of Kainate receptors;Synthesis of IP3 and IP4 in the cytosol;PLC beta mediated events;Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion;Acetylcholine regulates insulin secretion	PE1	11
+NX_Q01973	Inactive tyrosine-protein kinase transmembrane receptor ROR1	937	104283	6.76	1	Membrane;Axon;Cytoskeleton	Deafness, autosomal recessive, 108	Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).	NA	Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	PE1	1
+NX_Q01974	Tyrosine-protein kinase transmembrane receptor ROR2	943	104757	6.1	1	Cell membrane	Robinow syndrome autosomal recessive;Brachydactyly B1	Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443).	ROR2 is phosphorylated by GSK3A	Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	PCP/CE pathway;WNT5A-dependent internalization of FZD2, FZD5 and ROR2	PE1	9
+NX_Q01995	Transgelin	201	22611	8.87	0	Cytoplasm;Cytosol;Mitochondrion;Cytoskeleton	NA	Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.	NA	Belongs to the calponin family.	NA	PE1	11
+NX_Q02040	A-kinase anchor protein 17A	695	80735	9.76	0	Cytosol;Nucleus speckle	NA	Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.	NA	NA	NA	PE1	X
+NX_Q02045	Myosin light chain 5	173	19534	4.87	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	Focal adhesion;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Smooth Muscle Contraction	PE1	4
+NX_Q02078	Myocyte-specific enhancer factor 2A	507	54811	7.72	0	Nucleoplasm;Nucleus	Coronary artery disease, autosomal dominant, 1	Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.	Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 3 and caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.;Acetylation on Lys-403 activates transcriptional activity. Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity). Hyperacetylation by p300 leads to enhanced cardiac myocyte growth and heart failure.;Sumoylation on Lys-403 is enhanced by PIAS1 and represses transcriptional activity. Phosphorylation on Ser-408 is required for sumoylation. Has no effect on nuclear location nor on DNA binding. Sumoylated with SUMO1 and, to a lesser extent with SUMO2 and SUMO3. PIASx facilitates sumoylation in postsynaptic dendrites in the cerebellar cortex and promotes their morphogenesis (By similarity).;Constitutive phosphorylation on Ser-408 promotes Lys-403 sumoylation thus preventing acetylation at this site. Dephosphorylation on Ser-408 by PPP3CA upon neuron depolarization promotes a switch from sumoylation to acetylation on residue Lys-403 leading to inhibition of dendrite claw differentiation. Phosphorylation on Thr-312 and Thr-319 are the main sites involved in p38 MAPK signaling and activate transcription. Phosphorylated on these sites by MAPK14/p38alpha and MAPK11/p38beta, but not by MAPK13/p38delta nor by MAPK12/p38gamma. Phosphorylation on Ser-408 by CDK5 induced by neurotoxicity inhibits MEF2A transcriptional activation leading to apoptosis of cortical neurons. Phosphorylation on Thr-312, Thr-319 and Ser-355 can be induced by EGF.	Belongs to the MEF2 family.	ERK/MAPK targets;Myogenesis	PE1	15
+NX_Q02080	Myocyte-specific enhancer factor 2B	365	38639	9.58	0	Nucleoplasm;Cytosol;Cell junction;Nucleus	NA	Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.	NA	Belongs to the MEF2 family.	Myogenesis	PE1	19
+NX_Q02083	N-acylethanolamine-hydrolyzing acid amidase	359	40066	8.88	0	Membrane;Lysosome	NA	Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine (PubMed:15655246, PubMed:17980170, PubMed:18793752, PubMed:30301806). Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine (PubMed:15655246).	N-glycosylated (PubMed:17980170, PubMed:18793752, PubMed:30301806). Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine.;Autoproteolytic cleavage at pH 4.5 gives rise to the alpha and beta subunit (PubMed:15655246, PubMed:22040171, PubMed:17980170, PubMed:18793752, PubMed:30301806). Cleavage gives rise to a conformation change that activates the enzyme (PubMed:17980170, PubMed:18793752, PubMed:30301806, PubMed:22040171). The same catalytic Cys residue mediates the autoproteolytic cleavage and subsequent hydrolysis of lipid substrates (PubMed:17980170, PubMed:18793752) (Probable).;A disulfide bond is seen in the crystal structure of the human protein, but the Cys residues are not conserved in rodents.	Belongs to the acid ceramidase family.	Lipid metabolism; fatty acid metabolism.;Neurotransmitter release cycle	PE1	4
+NX_Q02086	Transcription factor Sp2	613	64900	9.95	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	17
+NX_Q02094	Ammonium transporter Rh type A	409	44198	6.35	12	Membrane;Endoplasmic reticulum	Regulator type Rh-null hemolytic anemia;Overhydrated hereditary stomatocytosis	Associated with rhesus blood group antigen expression (PubMed:19744193). May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane (PubMed:11062476, PubMed:11861637). Involved in ammonia transport across the erythrocyte membrane (PubMed:21849667, PubMed:22012326). Seems to act in monovalent cation transport (PubMed:18931342, PubMed:21849667).	Glycosylated.	Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.	Rhesus glycoproteins mediate ammonium transport;Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)	PE1	6
+NX_Q02108	Guanylate cyclase soluble subunit alpha-1	690	77452	6.75	0	Nucleoplasm;Cytoplasm	Moyamoya disease 6 with or without achalasia	NA	NA	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Vascular smooth muscle contraction;Gap junction;Long-term depression;Salivary secretion;Smooth Muscle Contraction;Nitric oxide stimulates guanylate cyclase	PE1	4
+NX_Q02127	Dihydroorotate dehydrogenase (quinone), mitochondrial	395	42867	9.66	1	Nucleoplasm;Cytosol;Mitochondrion inner membrane;Mitochondrion	Postaxial acrofacial dysostosis	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.	The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration.	Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.;Pyrimidine metabolism;Metabolic pathways;Pyrimidine biosynthesis	PE1	16
+NX_Q02153	Guanylate cyclase soluble subunit beta-1	619	70514	5.2	0	Cytoplasm;Cytosol	NA	Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.	NA	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Vascular smooth muscle contraction;Gap junction;Long-term depression;Salivary secretion;Smooth Muscle Contraction;Nitric oxide stimulates guanylate cyclase	PE1	4
+NX_Q02156	Protein kinase C epsilon type	737	83674	6.73	0	Cytoplasm;Cell membrane;Cytoplasmic vesicle;Perinuclear region;Nucleus;Cytoskeleton	NA	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.	Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729. Phosphorylation in the hinge domain at Ser-350 by MAPK11 or MAPK14, Ser-346 by GSK3B and Ser-368 by autophosphorylation is required for interaction with YWHAB.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Vascular smooth muscle contraction;Tight junction;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Type II diabetes mellitus;Effects of PIP2 hydrolysis;SHC1 events in ERBB2 signaling;G alpha (z) signalling events;Role of phospholipids in phagocytosis;DAG and IP3 signaling	PE1	2
+NX_Q02161	Blood group Rh(D) polypeptide	417	45211	8.71	11	Cytoplasm;Cell membrane	NA	May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.	Palmitoylated.	Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.	Rhesus blood group biosynthesis	PE1	1
+NX_Q02218	2-oxoglutarate dehydrogenase, mitochondrial	1023	115935	6.39	0	Mitochondrion matrix;Mitochondrion;Nucleus	NA	2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate (PubMed:24495017). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed:24495017). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).	OGDH is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	Belongs to the alpha-ketoglutarate dehydrogenase family.	Citrate cycle (TCA cycle);Lysine degradation;Tryptophan metabolism;Metabolic pathways;Citric acid cycle (TCA cycle);Lysine catabolism;Glyoxylate metabolism and glycine degradation	PE1	7
+NX_Q02221	Cytochrome c oxidase subunit 6A2, mitochondrial	97	10815	10.91	0	Mitochondrion inner membrane	NA	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase subunit 6A family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease	PE1	16
+NX_Q02223	Tumor necrosis factor receptor superfamily member 17	184	20165	5.24	1	Endomembrane system;Cell membrane	NA	Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.	NA	NA	Cytokine-cytokine receptor interaction;Intestinal immune network for IgA production;TNFs bind their physiological receptors	PE1	16
+NX_Q02224	Centromere-associated protein E	2701	316415	5.51	0	Nucleoplasm;Centromere;Cytosol;Spindle;Kinetochore;Cytoskeleton	Microcephaly 13, primary, autosomal recessive	Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:7889940, PubMed:23891108, PubMed:25395579). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity).	Sumoylated with SUMO2 and SUMO3. The sumoylation mediates the association to the kinetochore.;The C-terminal inhibitory domain is phosphorylated. Phosphorylation relieves autoinhibition of the kinetochore motor (By similarity).	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Separation of Sister Chromatids;MHC class II antigen presentation;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-dependent Golgi-to-ER retrograde traffic	PE1	4
+NX_Q02241	Kinesin-like protein KIF23	960	110059	8.76	0	Nucleoplasm;Spindle;Nucleus;Midbody ring	NA	Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.	Ubiquitinated. Deubiquitinated by USP8/UBPY.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	MHC class II antigen presentation;Kinesins;Mitotic Telophase/Cytokinesis;COPI-dependent Golgi-to-ER retrograde traffic	PE1	15
+NX_Q02246	Contactin-2	1040	113393	8.11	0	Cell membrane	Epilepsy, familial adult myoclonic, 5	In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.	NA	Belongs to the immunoglobulin superfamily. Contactin family.	Cell adhesion molecules (CAMs);NCAM1 interactions;L1CAM interactions;NrCAM interactions	PE1	1
+NX_Q02252	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	535	57840	8.72	0	Mitochondrion	Methylmalonate semialdehyde dehydrogenase deficiency	Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.	NA	Belongs to the aldehyde dehydrogenase family.	Valine, leucine and isoleucine degradation;beta-Alanine metabolism;Inositol phosphate metabolism;Propanoate metabolism;Metabolic pathways;Branched-chain amino acid catabolism	PE1	14
+NX_Q02297	Pro-neuregulin-1, membrane-bound isoform	640	70392	9	1	Cell membrane;Secreted;Membrane;Nucleoplasm;Nucleus	NA	Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart.;May play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).	Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.;N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage (By similarity).	Belongs to the neuregulin family.	ErbB signaling pathway;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;PI3K events in ERBB4 signaling;SHC1 events in ERBB4 signaling;Nuclear signaling by ERBB4;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;GRB7 events in ERBB2 signaling;Downregulation of ERBB2:ERBB3 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling;Long-term potentiation	PE1	8
+NX_Q02318	Sterol 26-hydroxylase, mitochondrial	531	60235	9.05	0	Mitochondrion inner membrane;Mitochondrion	Cerebrotendinous xanthomatosis	Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid (PubMed:9660774, PubMed:12077124, PubMed:21411718, PubMed:28190002). Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways (PubMed:9660774, PubMed:1708392, PubMed:11412116, PubMed:2019602, PubMed:7915755, PubMed:9186905, PubMed:9790667). May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism (PubMed:9660774, PubMed:12077124). Plays a role in cholestanol metabolism in the cerebellum. Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation (PubMed:28190002). Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium (PubMed:21411718). May play a redundant role in vitamin D biosynthesis. Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (PubMed:15465040).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; bile acid biosynthesis.;Steroid metabolism; cholesterol degradation.;Hormone biosynthesis; cholecalciferol biosynthesis.;Primary bile acid biosynthesis;Metabolic pathways;PPAR signaling pathway;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol;Endogenous sterols;Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)	PE1	2
+NX_Q02325	Plasminogen-like protein B	96	10971	6.11	0	Secreted	NA	May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.	NA	NA	NA	PE3	2
+NX_Q02338	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	343	38157	9.1	0	Mitochondrion matrix;Mitochondrion inner membrane;Mitochondrion	NA	NA	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Synthesis and degradation of ketone bodies;Butanoate metabolism;Metabolic pathways;Synthesis of Ketone Bodies;Utilization of Ketone Bodies	PE1	3
+NX_Q02363	DNA-binding protein inhibitor ID-2	134	14917	7.82	0	Cytoplasm;Nucleoplasm;Centrosome;Nucleus	NA	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.	NA	NA	TGF-beta signaling pathway	PE1	2
+NX_Q02383	Semenogelin-2	582	65444	9.09	0	Secreted	NA	Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.	Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide.	Belongs to the semenogelin family.	NA	PE1	20
+NX_Q02386	Zinc finger protein 45	682	78242	8.98	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q02388	Collagen alpha-1(VII) chain	2944	295220	5.95	0	Basement membrane	Epidermolysis bullosa dystrophica, autosomal recessive;Epidermolysis bullosa dystrophica, with subcorneal cleavage;Nail disorder, non-syndromic congenital, 8;Epidermolysis bullosa dystrophica, autosomal dominant;Epidermolysis bullosa dystrophica, Bart type;Epidermolysis bullosa dystrophica, pretibial type;Epidermolysis bullosa pruriginosa;Transient bullous dermolysis of the newborn	Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	NA	Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;Assembly of collagen fibrils and other multimeric structures;Laminin interactions;COPII-mediated vesicle transport;Anchoring fibril formation;Extracellular matrix organization;Cargo concentration in the ER;Collagen chain trimerization	PE1	3
+NX_Q02410	Amyloid-beta A4 precursor protein-binding family A member 1	837	92865	4.84	0	Golgi apparatus;Cytoplasm;Perinuclear region;Nucleus	NA	Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.	NA	NA	Dopamine Neurotransmitter Release Cycle;Neurexins and neuroligins;Assembly and cell surface presentation of NMDA receptors	PE1	9
+NX_Q02413	Desmoglein-1	1049	113748	4.9	1	Desmosome;Cell membrane	Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE;Palmoplantar keratoderma 1, striate, focal, or diffuse	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	NA	NA	Staphylococcus aureus infection;Apoptotic cleavage of cell adhesion proteins;Neutrophil degranulation;Formation of the cornified envelope;Keratinization	PE1	18
+NX_Q02446	Transcription factor Sp4	784	81985	6.61	0	Nucleoplasm;Cytosol;Nucleus	NA	Binds to GT and GC boxes promoters elements. Probable transcriptional activator.	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	7
+NX_Q02447	Transcription factor Sp3	781	81925	5.09	0	Nucleus;PML body	NA	Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.	Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity. Ceramides can also regulate acetylation/deacetylation events through altering the interaction of HDAC with SP3. In vitro, C(18)-ceramides, but not C(16)-ceramides, increase the interaction of HDAC1 with SP3 and enhance the deacetylation of SP3 and the subsequent repression of the TERT promoter.;Not glycosylated.;Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-551 being the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Sumoylation on Lys-551 represses the transactivation activity, except for the largest isoform, L-Sp3, which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity.	Belongs to the Sp1 C2H2-type zinc-finger protein family.	SUMOylation of transcription factors	PE1	2
+NX_Q02487	Desmocollin-2	901	99962	5.19	1	Desmosome;Cell membrane	Arrhythmogenic right ventricular dysplasia, familial, 11	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.	NA	NA	Arrhythmogenic right ventricular cardiomyopathy (ARVC);Formation of the cornified envelope;Keratinization	PE1	18
+NX_Q02505	Mucin-3A	3323	345127	5.14	1	Membrane;Secreted	NA	Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.	Highly O-glycosylated and probably also N-glycosylated.	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	7
+NX_Q02509	Otoconin-90	477	51728	4.76	0	Secreted	NA	Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity.	NA	Belongs to the phospholipase A2 family.	NA	PE2	8
+NX_Q02535	DNA-binding protein inhibitor ID-3	119	12999	5.55	0	Nucleoplasm;Nucleus	NA	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.	NA	NA	TGF-beta signaling pathway	PE1	1
+NX_Q02539	Histone H1.1	215	21842	10.99	0	Nucleus;Chromosome	NA	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).	Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.;H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.;HIST1H1A is phosphorylated by LMTK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the histone H1/H5 family.	Formation of Senescence-Associated Heterochromatin Foci (SAHF);Apoptosis induced DNA fragmentation	PE1	6
+NX_Q02543	60S ribosomal protein L18a	176	20762	10.72	0	Cytosol;Nucleolus	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL20 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_Q02548	Paired box protein Pax-5	391	42149	9.08	0	Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	Leukemia, acute lymphoblastic, 3	May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.	O-glycosylated.	NA	RUNX1 regulates transcription of genes involved in BCR signaling	PE1	9
+NX_Q02556	Interferon regulatory factor 8	426	48356	6.38	0	Cytoplasm;Nucleoplasm;Nucleus	Immunodeficiency 32A;Immunodeficiency 32B	Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed:29434592).	Sumoylated with SUMO3. Desumoylated by SENP1.;Ubiquitinated (PubMed:25122610). Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes (By similarity). Ubiquitination leads to its degradation by the proteasome (PubMed:25122610).	Belongs to the IRF family.	Pertussis;Interferon gamma signaling;Interferon alpha/beta signaling	PE1	16
+NX_Q02575	Helix-loop-helix protein 1	133	14618	9.06	0	Golgi apparatus;Nucleus	NA	May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.	NA	NA	NA	PE2	1
+NX_Q02577	Helix-loop-helix protein 2	135	15018	7.91	0	Nucleoplasm;Nucleus	NA	May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.	NA	NA	NA	PE1	1
+NX_Q02641	Voltage-dependent L-type calcium channel subunit beta-1	598	65714	6.33	0	Sarcolemma;Cell membrane	NA	Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964).	CACNB1 is phosphorylated by CAMK2D (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the calcium channel beta subunit family.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;NCAM1 interactions;Presynaptic depolarization and calcium channel opening;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	17
+NX_Q02643	Growth hormone-releasing hormone receptor	423	47402	6.26	7	Cell membrane	Growth hormone deficiency, isolated, 4	Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.	NA	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Glucagon-type ligand receptors	PE1	7
+NX_Q02742	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase	428	49799	8.65	1	Nucleus speckle;Golgi apparatus membrane	NA	Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes.	GCNT1 is phosphorylated by PRKCB (Phosphoserine:PTM-0253)	Belongs to the glycosyltransferase 14 family.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	9
+NX_Q02747	Guanylin	115	12388	4.56	0	Secreted	NA	Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.	NA	Belongs to the guanylin family.	Digestion	PE1	1
+NX_Q02750	Dual specificity mitogen-activated protein kinase kinase 1	393	43439	6.18	0	Cytoplasm;Cell membrane;Membrane;Spindle pole body;Centrosome;Cytosol;Nucleus	Cardiofaciocutaneous syndrome 3	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.	Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.;Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (BRAF or MEKK1) positively regulates kinase activity (PubMed:29433126, PubMed:8131746). Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK (PubMed:16129686). MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK (PubMed:16129686).;MAP2K1 is phosphorylated by CAMK2G (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP2K1 is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Vascular smooth muscle contraction;Dorso-ventral axis formation;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Gap junction;Toll-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Long-term depression;Regulation of actin cytoskeleton;Insulin signaling pathway;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Prion diseases;Influenza A;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Thyroid cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;Uptake and function of anthrax toxins;Signal transduction by L1;RAF activation;MAP2K and MAPK activation;MAPK3 (ERK1) activation;Negative feedback regulation of MAPK pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	15
+NX_Q02763	Angiopoietin-1 receptor	1124	125830	6.46	1	Cell membrane;Cell junction;Centriolar satellite;Focal adhesion;Secreted;Cytoskeleton	Dominantly inherited venous malformations;Glaucoma 3, primary congenital, E	Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1.	Ubiquitinated. The phosphorylated receptor is ubiquitinated and internalized, leading to its degradation.;Proteolytic processing leads to the shedding of the extracellular domain (soluble TIE-2 alias sTIE-2).;Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. One subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation occurs in a sequential manner, where Tyr-992 in the kinase activation loop is phosphorylated first, followed by autophosphorylation at Tyr-1108 and at additional tyrosine residues. ANGPT1-induced phosphorylation is impaired during hypoxia, due to increased expression of ANGPT2. Phosphorylation is important for interaction with GRB14, PIK3R1 and PTPN11. Phosphorylation at Tyr-1102 is important for interaction with SHC1, GRB2 and GRB7. Phosphorylation at Tyr-1108 is important for interaction with DOK2 and for coupling to downstream signal transduction pathways in endothelial cells. Dephosphorylated by PTPRB.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.	Rheumatoid arthritis;RAF/MAP kinase cascade;Tie2 Signaling	PE1	9
+NX_Q02779	Mitogen-activated protein kinase kinase kinase 10	954	103694	6.56	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	Activates the JUN N-terminal pathway.	Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.;MAP3K10 is phosphorylated by MAPK9 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	NA	PE1	19
+NX_Q02790	Peptidyl-prolyl cis-trans isomerase FKBP4	459	51805	5.35	0	Mitochondrion;Nucleoplasm;Cytosol;Axon;Nucleus;Cytoskeleton	NA	Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.	Phosphorylation by CK2 results in loss of HSP90 binding activity.	NA	Attenuation phase;HSP90 chaperone cycle for steroid hormone receptors (SHR);Estrogen-dependent gene expression;ESR-mediated signaling	PE1	12
+NX_Q02809	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	727	83550	6.46	0	Cytoplasmic vesicle;Nucleoplasm;Rough endoplasmic reticulum membrane	Ehlers-Danlos syndrome, kyphoscoliotic type, 1	Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:8621606, PubMed:10686424, PubMed:15854030). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable).	NA	NA	Lysine degradation;Collagen biosynthesis and modifying enzymes	PE1	1
+NX_Q02817	Mucin-2	5179	540300	5.49	0	Secreted	NA	Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.	At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.;May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.;O-glycosylated.	NA	Vibrio cholerae infection;Amoebiasis;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	11
+NX_Q02818	Nucleobindin-1	461	53879	5.15	0	Golgi apparatus;Cytoplasm;cis-Golgi network membrane;Secreted;Cytoskeleton	NA	Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity).	O-glycosylated.	Belongs to the nucleobindin family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	19
+NX_Q02833	Ras association domain-containing protein 7	373	39945	5.5	0	Centriolar satellite;Centrosome	NA	Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.	Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli.	NA	NA	PE1	11
+NX_Q02846	Retinal guanylyl cyclase 1	1103	120059	7.15	1	Membrane	Leber congenital amaurosis 1;Choroidal dystrophy, central areolar, 1;Cone-rod dystrophy 6	Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.	NA	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Olfactory transduction;Phototransduction;Inactivation, recovery and regulation of the phototransduction cascade	PE1	17
+NX_Q02878	60S ribosomal protein L6	288	32728	10.59	0	Cytoplasm;Cytosol;Rough endoplasmic reticulum;Cytoskeleton	NA	(Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378).;Component of the large ribosomal subunit.	NA	Belongs to the eukaryotic ribosomal protein eL6 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	12
+NX_Q02880	DNA topoisomerase 2-beta	1626	183267	8.14	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.	TOP2B is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the type II topoisomerase family.	SUMOylation of DNA replication proteins	PE1	3
+NX_Q02928	Cytochrome P450 4A11	519	59348	8.96	0	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PubMed:10553002, PubMed:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:15611369). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10620324, PubMed:10660572, PubMed:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PubMed:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PubMed:18065749). Has little activity toward prostaglandins A1 and E1 (PubMed:7679927).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; arachidonate metabolism.;Lipid metabolism; oxylipin biosynthesis.;Fatty acid metabolism;Arachidonic acid metabolism;Retinol metabolism;Metabolic pathways;PPAR signaling pathway;Vascular smooth muscle contraction;Miscellaneous substrates;PPARA activates gene expression;Fatty acids;Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE);Eicosanoids;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	1
+NX_Q02930	Cyclic AMP-responsive element-binding protein 5	508	56918	8.76	0	Nucleoplasm;Cell membrane;Nucleus;Cytoplasmic vesicle	NA	Binds to the cAMP response element and activates transcription.	NA	Belongs to the bZIP family.	Cholinergic synapse;Dopaminergic synapse;Vasopressin-regulated water reabsorption;Huntington's disease;Prostate cancer	PE1	7
+NX_Q02952	A-kinase anchor protein 12	1782	191482	4.37	0	Cytoplasm;Cell cortex;Cell membrane;Membrane;Cytosol;Cytoskeleton	NA	Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).	NA	NA	NA	PE1	6
+NX_Q02962	Paired box protein Pax-2	417	44706	7.25	0	Golgi apparatus;Nucleolus;Nucleus	Focal segmental glomerulosclerosis 7;Papillorenal syndrome	Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS.	NA	NA	NA	PE1	10
+NX_Q02978	Mitochondrial 2-oxoglutarate/malate carrier protein	314	34062	9.92	6	Mitochondrion inner membrane	NA	Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Gluconeogenesis	PE1	17
+NX_Q02985	Complement factor H-related protein 3	330	37323	7.72	0	Secreted	Hemolytic uremic syndrome atypical 1	Might be involved in complement regulation.	NA	NA	Regulation of Complement cascade	PE1	1
+NX_Q03001	Dystonin	7570	860662	5.14	0	Cell cortex;Endoplasmic reticulum membrane;Cell membrane;H zone;Hemidesmosome;Membrane;Nucleoplasm;Stress fiber;Nucleus envelope;Cytosol;Axon;Z line;Nucleus;Cytoskeleton	Epidermolysis bullosa simplex, autosomal recessive 2;Neuropathy, hereditary sensory and autonomic, 6	Required for bundling actin filaments around the nucleus.;Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.;Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.;Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity).	NA	NA	Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly	PE1	6
+NX_Q03013	Glutathione S-transferase Mu 4	218	25561	5.6	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1-chloro-2,4-dinitrobenzene.	NA	Belongs to the GST superfamily. Mu family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation;Biosynthesis of maresin conjugates in tissue regeneration (MCTR)	PE1	1
+NX_Q03014	Hematopoietically-expressed homeobox protein HHEX	270	30022	6.72	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).	NA	NA	Maturity onset diabetes of the young	PE1	10
+NX_Q03052	POU domain, class 3, transcription factor 1	451	45496	7.29	0	Nucleoplasm;Nucleus	NA	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.	NA	Belongs to the POU transcription factor family. Class-3 subfamily.	NA	PE1	1
+NX_Q03060	cAMP-responsive element modulator	345	37006	5.4	0	Nucleoplasm;Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.;Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).	Is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.;Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro.;CREM is phosphorylated by CAMK1D (Phosphoserine:PTM-0253)	Belongs to the bZIP family.	Circadian Clock	PE1	10
+NX_Q03111	Protein ENL	559	62056	8.75	0	Nucleoplasm;Nucleus	NA	Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.	NA	NA	Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation	PE1	19
+NX_Q03112	Histone-lysine N-methyltransferase MECOM	1230	138136	6	0	Cytoplasm;Nucleus speckle;Nucleus	Radioulnar synostosis with amegakaryocytic thrombocytopenia 2	Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.;Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.	May be acetylated by CREBBP and KAT2B.;Phosphorylated.	NA	PKMTs methylate histone lysines;Regulation of PTEN gene transcription	PE1	3
+NX_Q03113	Guanine nucleotide-binding protein subunit alpha-12	381	44279	9.84	0	Cytoplasm;Cytosol;Lateral cell membrane;Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).	NA	Belongs to the G-alpha family. G(12) subfamily.	MAPK signaling pathway;Vascular smooth muscle contraction;Long-term depression;Regulation of actin cytoskeleton;G alpha (12/13) signalling events;Thrombin signalling through proteinase activated receptors (PARs)	PE1	7
+NX_Q03135	Caveolin-1	178	20472	5.64	0	trans-Golgi network;Golgi apparatus;Cytoplasm;Cell membrane;Caveola;Golgi apparatus membrane;Membrane raft;Nucleus	Congenital generalized lipodystrophy 3;Lipodystrophy, familial partial, 7;Pulmonary hypertension, primary, 3	May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).	Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination (PubMed:21822278). Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation (PubMed:23335559).;The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.;Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.	Belongs to the caveolin family.	Endocytosis;Focal adhesion;Bacterial invasion of epithelial cells;Viral myocarditis;VEGFR2 mediated vascular permeability;Triglyceride catabolism;Basigin interactions;Disassembly of the destruction complex and recruitment of AXIN to the membrane;eNOS activation;NOSTRIN mediated eNOS trafficking;Extra-nuclear estrogen signaling;FOXO-mediated transcription of cell cycle genes	PE1	7
+NX_Q03154	Aminoacylase-1	408	45885	5.77	0	Cytoplasm	Aminoacylase-1 deficiency	Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).	NA	Belongs to the peptidase M20A family.	Arginine and proline metabolism;Metabolic pathways;Aflatoxin activation and detoxification;Defective ACY1 causes encephalopathy	PE1	3
+NX_Q03164	Histone-lysine N-methyltransferase 2A	3969	431764	9.22	0	Nucleoplasm;Cytosol;Nucleus	Wiedemann-Steiner syndrome	Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation (PubMed:12453419, PubMed:20677832, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity).	Proteolytic cleavage by TASP1 generates MLL cleavage product N320 and MLL cleavage product C180, which reassemble through a non-covalent association. 2 cleavage sites exist, cleavage site 1 (CS1) and cleavage site 2 (CS2), to generate MLL cleavage products N320 and C180. CS2 is the major site.	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	Lysine degradation;PKMTs methylate histone lysines;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Transcriptional regulation of granulopoiesis	PE1	11
+NX_Q03167	Transforming growth factor beta receptor type 3	851	93499	5.45	1	Cell membrane;Cytosol;Secreted;Extracellular space	NA	Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.	Extensively modified by glycosaminoglycan groups (GAG).	NA	NA	PE1	1
+NX_Q03169	Tumor necrosis factor alpha-induced protein 2	654	72661	6.06	0	Golgi apparatus;Nucleoplasm;Nucleus membrane;Cytosol	NA	May play a role as a mediator of inflammation and angiogenesis.	NA	Belongs to the SEC6 family.	NA	PE1	14
+NX_Q03181	Peroxisome proliferator-activated receptor delta	441	49903	7.53	0	Nucleus	NA	Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.	NA	Belongs to the nuclear hormone receptor family. NR1 subfamily.	PPAR signaling pathway;Wnt signaling pathway;Pathways in cancer;Acute myeloid leukemia;Nuclear Receptor transcription pathway;Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex;Import of palmitoyl-CoA into the mitochondrial matrix	PE1	6
+NX_Q03188	Centromere protein C	943	106834	9.43	0	Nucleoplasm;Nucleus;Centromere;Kinetochore	NA	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.	NA	Belongs to the CENP-C/MIF2 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	4
+NX_Q03252	Lamin-B2	620	69948	5.5	0	Nucleus inner membrane;Nucleus membrane	Partial acquired lipodystrophy;Epilepsy, progressive myoclonic 9	Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.	B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.	Belongs to the intermediate filament family.	NA	PE1	19
+NX_Q03393	6-pyruvoyl tetrahydrobiopterin synthase	145	16386	6.2	0	Cytosol	Hyperphenylalaninemia, BH4-deficient, A	Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.	Phosphorylation of Ser-19 is required for maximal enzyme activity.	Belongs to the PTPS family.	Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.;Folate biosynthesis;Metabolic pathways;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	PE1	11
+NX_Q03395	Rod outer segment membrane protein 1	351	37205	5.65	4	Photoreceptor inner segment membrane;Cytosol;Photoreceptor outer segment membrane;Cell membrane	Retinitis pigmentosa 7	Plays a role in rod outer segment (ROS) morphogenesis (By similarity). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (By similarity). Plays a role in the organization of the ROS and maintenance of ROS disk diameter (By similarity). Involved in the maintenance of the retina outer nuclear layer (By similarity).	NA	Belongs to the PRPH2/ROM1 family.	NA	PE1	11
+NX_Q03403	Trefoil factor 2	129	14284	5.51	0	Secreted	NA	Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).	NA	NA	NA	PE1	21
+NX_Q03405	Urokinase plasminogen activator surface receptor	335	36978	6.19	0	Secreted;Invadopodium membrane;Cell membrane	NA	Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.	NA	NA	Complement and coagulation cascades;Attachment of GPI anchor to uPAR;Dissolution of Fibrin Clot;Neutrophil degranulation	PE1	19
+NX_Q03426	Mevalonate kinase	396	42451	6.02	0	Cytoplasmic vesicle;Cytosol;Cytoplasm;Peroxisome	Hyperimmunoglobulinemia D and periodic fever syndrome;Mevalonic aciduria;Porokeratosis 3, multiple types	Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:9325256, PubMed:18302342).	NA	Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.;Terpenoid backbone biosynthesis;Metabolic pathways;Peroxisome;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	12
+NX_Q03431	Parathyroid hormone/parathyroid hormone-related peptide receptor	593	66361	8.25	7	Cell membrane	Enchondromatosis multiple;Metaphyseal chondrodysplasia, Jansen type;Primary failure of tooth eruption;Chondrodysplasia Blomstrand type;Eiken skeletal dysplasia	Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.	N-glycosylated.	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;Endocrine and other factor-regulated calcium reabsorption;G alpha (s) signalling events;Class B/2 (Secretin family receptors)	PE1	3
+NX_Q03468	DNA excision repair protein ERCC-6	1493	168416	8.28	0	Nucleus	UV-sensitive syndrome 1;De Sanctis-Cacchione syndrome;Cerebro-oculo-facio-skeletal syndrome 1;Cockayne syndrome B;Macular degeneration, age-related, 5	Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:20541997, PubMed:26620705). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). It is required for transcription-coupled repair complex formation (PubMed:16916636). It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-blocking lesions (PubMed:16916636). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function. Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740).	Sumoylation at Lys-205 in an UV-radiation-dependent manner is essential for its transcription-coupled nucleotide excision repair activity.;Phosphorylated in a cell cycle-dependent manner at Ser-158 by cyclin A-CDK2 and at Ser-10 by ATM in response to DNA damage (PubMed:29203878). Phosphorylation at these two sites promotes the intramolecular interaction of the N-terminal domain with the helicase ATP-binding domain, thereby probably releasing the inhibitory effect of the N-terminal domain on its ATPase activity (PubMed:29203878). Phosphorylation is essential for its chromatin remodeling activity (PubMed:29203878).;Ubiquitinated at the C-terminus. Ubiquitination by the CSA complex leads to ERCC6 proteasomal degradation in a UV-dependent manner. Stabilized following interaction with KIAA1530/UVSSA, which promotes recruitment of deubiquitinating enzyme USP7, leading to deubiquitination of ERCC6 thereby preventing UV-induced degradation of ERCC6 by the proteasome.	Belongs to the SNF2/RAD54 helicase family.	Nucleotide excision repair;RNA Polymerase I Transcription Initiation;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	PE1	10
+NX_Q03518	Antigen peptide transporter 1	808	87218	8.24	10	Endoplasmic reticulum membrane;Endoplasmic reticulum;Centriolar satellite	Bare lymphocyte syndrome 1	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.	NA	Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.	ABC transporters;Phagosome;Antigen processing and presentation;Herpes simplex infection;Primary immunodeficiency;ER-Phagosome pathway;Antigen Presentation: Folding, assembly and peptide loading of class I MHC	PE1	6
+NX_Q03519	Antigen peptide transporter 2	686	75664	8.24	9	Endoplasmic reticulum membrane;Endoplasmic reticulum;Nucleus speckle	Bare lymphocyte syndrome 1	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.	NA	Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.	ABC transporters;Phagosome;Antigen processing and presentation;Herpes simplex infection;Primary immunodeficiency;ER-Phagosome pathway;Antigen Presentation: Folding, assembly and peptide loading of class I MHC	PE1	6
+NX_Q03591	Complement factor H-related protein 1	330	37651	7.39	0	Secreted	Hemolytic uremic syndrome atypical 1	Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.	N-glycosylated. Two forms are observed; one with a single side chain and the other with two.	NA	Regulation of Complement cascade	PE1	1
+NX_Q03692	Collagen alpha-1(X) chain	680	66158	9.68	0	Endoplasmic reticulum;Extracellular matrix	Schmid type metaphyseal chondrodysplasia	Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	NA	Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;Assembly of collagen fibrils and other multimeric structures;Non-integrin membrane-ECM interactions;Collagen chain trimerization	PE1	6
+NX_Q03701	CCAAT/enhancer-binding protein zeta	1054	120974	5.65	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Stimulates transcription from the HSP70 promoter.	NA	Belongs to the CBF/MAK21 family.	NA	PE1	2
+NX_Q03721	Potassium voltage-gated channel subfamily C member 4	635	69767	6.56	6	Membrane;Cytosol;Nucleolus	NA	This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.	Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily.	Voltage gated Potassium channels	PE1	1
+NX_Q03828	Homeobox even-skipped homolog protein 2	476	47800	9.12	0	Nucleus	NA	NA	NA	Belongs to the even-skipped homeobox family.	NA	PE2	2
+NX_Q03923	Zinc finger protein 85	595	68736	9.45	0	Nucleoplasm;Nucleus	NA	May be a transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q03924	Zinc finger protein 117	483	56376	9.46	0	Nucleolus;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE2	7
+NX_Q03933	Heat shock factor protein 2	536	60348	4.7	0	Cytoplasm;Nucleoplasm;Nucleus	NA	DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.	NA	Belongs to the HSF family.	NA	PE1	6
+NX_Q03936	Zinc finger protein 92	586	68487	9.4	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q03938	Zinc finger protein 90	601	69058	9.36	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q03989	AT-rich interactive domain-containing protein 5A	594	64074	9.34	0	Nucleoplasm;Nucleolus;Nucleus	NA	Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity).	Phosphorylated by MAPK14 on serine residues involving a TLR4 signaling pathway upon lipopolysaccharide (LPS) stimulation leading to its ubiquitination and proteasomal degradation.;Ubiquitinated leading to proteasomal degradation; involving WWP1 linked to MAPK14-mediated phosphorylation upon LPS stimulation.	NA	NA	PE1	2
+NX_Q04118	Basic salivary proline-rich protein 3	309	30980	10.8	0	Secreted	NA	Acts as a receptor for the Gram-negative bacterium F.nucleatum.	Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine. The endoprotease may be of microbial origin. Besides on the N-terminal of mature PRB3, pyroglutamate formation found on at least Gln-67, Gln-88, Gln-214 and Gln-295.;N- and O-glycosylated; contains about 50% carbohydrate. This is composed of highly fucosylated N-linked saccharides, the major structure is a biantennary asialosaccharide containing 2 fucose residues on one antenna and an unsubstituted terminal lactosamine sequence on the other. The Gram-negative bacterium F.nucleatum binds to carbohydrates containing unsubstituted GalBeta1,4GlcNAc residues. N-glycosylation on Asn-87 is prevalent in head and neck cancer patients.;The Gl-8 variant contains an interchain disulfide bond with salivary peroxidase.	NA	NA	PE1	12
+NX_Q04206	Transcription factor p65	551	60219	5.46	0	Cytoplasm;Cytosol;Nucleus	Mucocutaneous ulceration, chronic	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression.	Phosphorylation at Ser-311 disrupts the interaction with EHMT1 and promotes transcription factor activity (By similarity). Phosphorylation on Ser-536 stimulates acetylation on Lys-310 and interaction with CBP; the phosphorylated and acetylated forms show enhanced transcriptional activity. Phosphorylation at Ser-276 by RPS6KA4 and RPS6KA5 promotes its transactivation and transcriptional activities.;Sumoylation by PIAS3 negatively regulates DNA-bound activated NF-kappa-B.;Sulfhydration at Cys-38 mediates the anti-apoptotic activity by promoting the interaction with RPS3 and activating the transcription factor activity.;Ubiquitinated by RNF182, leading to its proteasomal degradation. Degradation is required for termination of NF-kappa-B response.;S-nitrosylation of Cys-38 inactivates the enzyme activity.;Proteolytically cleaved within a conserved N-terminus region required for base-specific contact with DNA in a CPEN1-mediated manner, and hence inhibits NF-kappa-B transcriptional activity (PubMed:18212740).;Reversibly acetylated; the acetylation seems to be mediated by CBP, the deacetylation by HDAC3 and SIRT2. Acetylation at Lys-122 enhances DNA binding and impairs association with NFKBIA. Acetylation at Lys-310 is required for full transcriptional activity in the absence of effects on DNA binding and NFKBIA association. Acetylation at Lys-310 promotes interaction with BRD4. Acetylation can also lower DNA-binding and results in nuclear export. Interaction with BRMS1 promotes deacetylation of Lys-310. Lys-310 is deacetylated by SIRT2.;Monomethylated at Lys-310 by SETD6. Monomethylation at Lys-310 is recognized by the ANK repeats of EHMT1 and promotes the formation of repressed chromatin at target genes, leading to down-regulation of NF-kappa-B transcription factor activity. Phosphorylation at Ser-311 disrupts the interaction with EHMT1 without preventing monomethylation at Lys-310 and relieves the repression of target genes (By similarity).	NA	MAPK signaling pathway;Chemokine signaling pathway;Apoptosis;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Neurotrophin signaling pathway;Adipocytokine signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Salmonella infection;Pertussis;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Tuberculosis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Herpes simplex infection;Pathways in cancer;Pancreatic cancer;Prostate cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Activation of NF-kappaB in B cells;FCERI mediated NF-kB activation;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;PKMTs methylate histone lysines;Downstream TCR signaling;The NLRP3 inflammasome;Senescence-Associated Secretory Phenotype (SASP);RIP-mediated NFkB activation via ZBP1;DEx/H-box helicases activate type I IFN and inflammatory cytokines production;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;Transcriptional regulation of white adipocyte differentiation;CLEC7A/inflammasome pathway;CD209 (DC-SIGN) signaling;IkBA variant leads to EDA-ID;Regulated proteolysis of p75NTR;NF-kB is activated and signals survival;Interleukin-1 processing;Interleukin-1 signaling;SUMOylation of immune response proteins	PE1	11
+NX_Q04323	UBX domain-containing protein 1	297	33325	5.23	0	Nucleoplasm;Cytoplasm	NA	Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172). Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.	NA	NA	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	PE1	11
+NX_Q04446	1,4-alpha-glucan-branching enzyme	702	80474	5.87	0	Nucleoplasm;Cytosol	Glycogen storage disease 4;Polyglucosan body neuropathy, adult form	Required for normal glycogen accumulation (PubMed:8463281, PubMed:26199317, PubMed:8613547). The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable).	NA	Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.	Glycan biosynthesis; glycogen biosynthesis.;Starch and sucrose metabolism;Metabolic pathways;Glycogen synthesis;Glycogen storage disease type IV (GBE1)	PE1	3
+NX_Q04609	Glutamate carboxypeptidase 2	750	84331	6.5	1	Cytoplasm;Cell membrane	NA	Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.;Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.	The N-terminus is blocked.;The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.	Belongs to the peptidase M28 family. M28B subfamily.	Vitamin digestion and absorption;Aspartate and asparagine metabolism	PE1	11
+NX_Q04637	Eukaryotic translation initiation factor 4 gamma 1	1599	175491	5.25	0	Cytosol	Parkinson disease 18	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.	Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.;Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.;EIF4G1 is phosphorylated by MAPK3;EIF4G1 is phosphorylated by PAK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the eukaryotic initiation factor 4G family.	RNA transport;Viral myocarditis;AUF1 (hnRNP D0) binds and destabilizes mRNA;ISG15 antiviral mechanism;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Deadenylation of mRNA;mTORC1-mediated signalling;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Regulation of expression of SLITs and ROBOs	PE1	3
+NX_Q04656	Copper-transporting ATPase 1	1500	163373	5.92	8	Golgi apparatus;Cell membrane;trans-Golgi network membrane;Endoplasmic reticulum;Cytoplasmic vesicle;Cytosol	Menkes disease;Occipital horn syndrome;Distal spinal muscular atrophy, X-linked, 3	May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.	Mineral absorption;Ion transport by P-type ATPases;Detoxification of Reactive Oxygen Species;Ion influx/efflux at host-pathogen interface	PE1	X
+NX_Q04671	P protein	838	92850	6.84	12	Cytosol;Melanosome membrane;Cell membrane	Albinism, oculocutaneous, 2	Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.	NA	Belongs to the CitM (TC 2.A.11) transporter family.	Melanin biosynthesis	PE1	15
+NX_Q04695	Keratin, type I cytoskeletal 17	432	48106	4.97	0	Cytoplasm	Pachyonychia congenita 2;Steatocystoma multiplex	Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.	Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q04721	Neurogenic locus notch homolog protein 2	2471	265405	4.95	1	Nucleoplasm;Cytoplasm;Nucleus;Cell membrane	Hajdu-Cheney syndrome;Alagille syndrome 2	Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).	Hydroxylated by HIF1AN.;Can be either O-glucosylated or O-xylosylated at Ser-613 by POGLUT1.;Phosphorylated by GSK3. GSK3-mediated phosphorylation is necessary for NOTCH2 recognition by FBXW7, ubiquitination and degradation via the ubiquitin proteasome pathway.;Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form (By similarity). Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC) (By similarity). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT) (By similarity). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity).	Belongs to the NOTCH family.	Dorso-ventral axis formation;Notch signaling pathway;Pre-NOTCH Processing in the Endoplasmic Reticulum;Pre-NOTCH Transcription and Translation;Pre-NOTCH Processing in Golgi;Notch-HLH transcription pathway;NOTCH2 intracellular domain regulates transcription;NOTCH2 Activation and Transmission of Signal to the Nucleus;Defective LFNG causes SCDO3;NOTCH4 Intracellular Domain Regulates Transcription	PE1	1
+NX_Q04724	Transducin-like enhancer protein 1	770	83201	6.79	0	Nucleoplasm;Nucleus	NA	Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.	Ubiquitinated by XIAP/BIRC4.;Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.	Belongs to the WD repeat Groucho/TLE family.	Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex;Repression of WNT target genes;NOTCH1 Intracellular Domain Regulates Transcription	PE1	9
+NX_Q04725	Transducin-like enhancer protein 2	743	79841	6.16	0	Focal adhesion;Nucleus	NA	Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).	Ubiquitinated by XIAP/BIRC4.	Belongs to the WD repeat Groucho/TLE family.	Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex;Repression of WNT target genes;NOTCH1 Intracellular Domain Regulates Transcription	PE1	19
+NX_Q04726	Transducin-like enhancer protein 3	772	83417	6.72	0	Nucleoplasm;Nucleus	NA	Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).	Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.	Belongs to the WD repeat Groucho/TLE family.	Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex;Repression of WNT target genes;NOTCH1 Intracellular Domain Regulates Transcription;Estrogen-dependent gene expression	PE1	15
+NX_Q04727	Transducin-like enhancer protein 4	773	83755	7.2	0	Nucleoplasm;Nucleus	NA	Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).	Ubiquitinated by XIAP/BIRC4.;Phosphorylated. PAX5 binding increases phosphorylation (By similarity).	Belongs to the WD repeat Groucho/TLE family.	Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex;Repression of WNT target genes;NOTCH1 Intracellular Domain Regulates Transcription	PE1	9
+NX_Q04741	Homeobox protein EMX1	257	28039	9.85	0	Cytoplasm;Nucleus;Nucleolus	NA	Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.	NA	Belongs to the EMX homeobox family.	NA	PE1	2
+NX_Q04743	Homeobox protein EMX2	252	28303	9.83	0	Nucleoplasm;Nucleus	Schizencephaly	Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.	NA	Belongs to the EMX homeobox family.	NA	PE1	10
+NX_Q04756	Hepatocyte growth factor activator	655	70682	6.99	0	Secreted	NA	Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.	NA	Belongs to the peptidase S1 family.	MET Receptor Activation	PE1	4
+NX_Q04759	Protein kinase C theta type	706	81865	7.69	0	Cytoplasm;Centriolar satellite;Cell membrane	NA	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1.	Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PRKCQ upon antigen receptor ligation. Following TCR stimulation, phosphorylated at Tyr-90 and Ser-685.;PRKCQ is phosphorylated by FYN (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Vascular smooth muscle contraction;Tight junction;T cell receptor signaling pathway;Adipocytokine signaling pathway;Measles;FCERI mediated NF-kB activation;Downstream TCR signaling;Effects of PIP2 hydrolysis;Netrin-1 signaling;Inactivation, recovery and regulation of the phototransduction cascade;G alpha (z) signalling events;Apoptotic cleavage of cellular proteins;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	10
+NX_Q04760	Lactoylglutathione lyase	184	20778	5.12	0	Nucleoplasm;Cytosol;Cell membrane	NA	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.	Glutathionylation at Cys-139 inhibits enzyme activity.;Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B.;Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B.	Belongs to the glyoxalase I family.	Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.;Pyruvate metabolism;Pyruvate metabolism	PE1	6
+NX_Q04771	Activin receptor type-1	509	57153	7.12	1	Membrane;Cytosol;Nucleolus	Fibrodysplasia ossificans progressiva	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).	NA	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway	PE1	2
+NX_Q04828	Aldo-keto reductase family 1 member C1	323	36788	8.02	0	Cytoplasm	NA	Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.	NA	Belongs to the aldo/keto reductase family.	Steroid hormone biosynthesis;Metabolism of xenobiotics by cytochrome P450;Retinoid metabolism and transport;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol	PE1	10
+NX_Q04837	Single-stranded DNA-binding protein, mitochondrial	148	17260	9.59	0	Mitochondrion;Mitochondrion nucleoid	NA	This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.	NA	NA	DNA replication;Mismatch repair;Homologous recombination;Transcriptional activation of mitochondrial biogenesis	PE1	7
+NX_Q04844	Acetylcholine receptor subunit epsilon	493	54697	5.15	4	Cell membrane;Postsynaptic cell membrane	Myasthenic syndrome, congenital, 4B, fast-channel;Myasthenic syndrome, congenital, 4A, slow-channel;Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.	Neuroactive ligand-receptor interaction;Highly sodium permeable acetylcholine nicotinic receptors	PE1	17
+NX_Q04864	Proto-oncogene c-Rel	619	68520	5.56	0	Nucleus	NA	Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.	REL is phosphorylated by IKBKE	NA	Activation of NF-kappaB in B cells	PE1	2
+NX_Q04900	Sialomucin core protein 24	197	20917	8.3	1	Cell membrane;Endosome membrane;Lysosome membrane;Secreted;Endoplasmic reticulum;Endosome	Deafness, autosomal dominant, 66	Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).	The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.;Highly N- and O-glycosylated; contains sialic acid.	Belongs to the CD164 family.	Lysosome	PE1	6
+NX_Q04912	Macrophage-stimulating protein receptor	1400	152241	6.09	1	Membrane;Cytosol	Nasopharyngeal carcinoma, 3	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.	Proteolytic processing yields the two subunits.;Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site.;Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.	Belongs to the protein kinase superfamily. Tyr protein kinase family.	Signaling by MST1	PE1	3
+NX_Q04917	14-3-3 protein eta	246	28219	4.76	0	Cytoplasm	NA	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.	Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.	Belongs to the 14-3-3 family.	Cell cycle;Oocyte meiosis;Neurotrophin signaling pathway;Translocation of SLC2A4 (GLUT4) to the plasma membrane;TP53 Regulates Metabolic Genes;Activation of BAD and translocation to mitochondria;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;RHO GTPases activate PKNs	PE1	22
+NX_Q04941	Proteolipid protein 2	152	16691	6.8	4	Membrane	NA	May play a role in cell differentiation in the intestinal epithelium.	NA	NA	NA	PE1	X
+NX_Q05048	Cleavage stimulation factor subunit 1	431	48358	6.12	0	Nucleoplasm;Nucleus	NA	One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (PubMed:10669729). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (PubMed:10669729).	The N-terminus is blocked.	NA	mRNA surveillance pathway;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	20
+NX_Q05066	Sex-determining region Y protein	204	23884	9.55	0	Cytoplasm;Nucleus speckle;Nucleus	46,XY sex reversal 1;46,XX sex reversal 1	Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.	Phosphorylated on serine residues by PKA. Phosphorylation by PKA enhances its DNA-binding activity and stimulates transcription repression.;Acetylation of Lys-136 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3.;Poly-ADP-ribosylated by PARP1. ADP-ribosylation reduces its DNA-binding activity.	Belongs to the SRY family.	Deactivation of the beta-catenin transactivating complex	PE1	Y
+NX_Q05084	Islet cell autoantigen 1	483	54645	5.55	0	Cytoplasm;Synaptic vesicle membrane;Secretory vesicle membrane;Golgi apparatus membrane;Cytoplasmic vesicle;Cytosol	NA	May play a role in neurotransmitter secretion.	NA	NA	Type I diabetes mellitus	PE1	7
+NX_Q05086	Ubiquitin-protein ligase E3A	875	100688	5.12	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Angelman syndrome	(Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses.;E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990). Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533).	Phosphorylation at Tyr-659 by ABL1 impairs E3 ligase activity and protects p53/TP53 from degradation in (HPV)-infected cells.	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	15
+NX_Q05193	Dynamin-1	864	97408	6.73	0	Cytoplasm;Nucleoplasm;Cytoskeleton	Epileptic encephalopathy, early infantile, 31	Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.	DNM1 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Endocytosis;Fc gamma R-mediated phagocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Bacterial invasion of epithelial cells;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Toll Like Receptor 4 (TLR4) Cascade;Retrograde neurotrophin signalling;Recycling pathway of L1;Gap junction degradation;Formation of annular gap junctions;Clathrin-mediated endocytosis	PE1	9
+NX_Q05195	Max dimerization protein 1	221	25254	8.68	0	Nucleoplasm;Cytosol;Mitochondrion;Nucleus	NA	Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.	Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome.	NA	NA	PE1	2
+NX_Q05209	Tyrosine-protein phosphatase non-receptor type 12	780	88106	5.4	0	Cytoplasm;Cell membrane;Podosome;Focal adhesion;Cytosol	NA	Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).	Phosphorylated by STK24/MST3 and this results in inhibition of its activity.;PTPN12 is phosphorylated by STK24 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.	Signaling by PDGF;EGFR downregulation;SHC1 events in ERBB2 signaling;Downregulation of ERBB2 signaling;Interleukin-37 signaling	PE1	7
+NX_Q05215	Early growth response protein 4	589	61623	8.74	0	Nucleus	NA	Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).	NA	Belongs to the EGR C2H2-type zinc-finger protein family.	NA	PE2	2
+NX_Q05315	Galectin-10	142	16453	6.83	0	Cytosol;Cytoplasmic granule	NA	Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).	NA	NA	NA	PE1	19
+NX_Q05329	Glutamate decarboxylase 2	585	65411	6.45	0	Cytoplasmic vesicle;Cytosol;Presynaptic cell membrane;Golgi apparatus membrane	NA	Catalyzes the production of GABA.	Palmitoylated; which is required for presynaptic clustering.;Phosphorylated; which does not affect kinetic parameters or subcellular location.	Belongs to the group II decarboxylase family.	Alanine, aspartate and glutamate metabolism;beta-Alanine metabolism;Taurine and hypotaurine metabolism;Butanoate metabolism;Metabolic pathways;GABAergic synapse;Type I diabetes mellitus;GABA synthesis;GABA synthesis, release, reuptake and degradation;MECP2 regulates transcription of genes involved in GABA signaling	PE1	10
+NX_Q05397	Focal adhesion kinase 1	1052	119233	6.19	0	Cell cortex;Cell membrane;Focal adhesion;Centrosome;Cytoplasmic vesicle;Cytosol;Nucleus;Cytoskeleton	NA	(FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.;Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1.	Sumoylated; this enhances autophosphorylation.;Phosphorylated on tyrosine residues upon activation, e.g. Upon integrin signaling. Tyr-397 is the major autophosphorylation site, but other kinases can also phosphorylate this residue. Phosphorylation at Tyr-397 promotes interaction with SRC and SRC family members, leading to phosphorylation at Tyr-576, Tyr-577 and at additional tyrosine residues. FGR promotes phosphorylation at Tyr-397 and Tyr-576. FER promotes phosphorylation at Tyr-577, Tyr-861 and Tyr-925, even when cells are not adherent. Tyr-397, Tyr-576 and Ser-722 are phosphorylated only when cells are adherent. Phosphorylation at Tyr-397 is important for interaction with BMX, PIK3R1 and SHC1. Phosphorylation at Tyr-925 is important for interaction with GRB2. Dephosphorylated by PTPN11; PTPN11 is recruited to PTK2 via EPHA2 (tyrosine phosphorylated). Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly; this dephosphorylation could be catalyzed by PTPN11 and regulated by ZFYVE21. Phosphorylation on tyrosine residues is enhanced by NTN1 (By similarity).;PTK2 is phosphorylated by EPHA1	Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.	ErbB signaling pathway;Chemokine signaling pathway;Axon guidance;VEGF signaling pathway;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Amoebiasis;Pathways in cancer;Small cell lung cancer;RAF/MAP kinase cascade;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;EPHB-mediated forward signaling;VEGFA-VEGFR2 Pathway;Apoptotic cleavage of cellular proteins;Signal regulatory protein family interactions;NCAM signaling for neurite out-growth;DCC mediated attractive signaling;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;MET activates PTK2 signaling;Extra-nuclear estrogen signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	8
+NX_Q05469	Hormone-sensitive lipase	1076	116598	6.25	0	Cytosol;Caveola;Cell membrane	Lipodystrophy, familial partial, 6	In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.	Phosphorylation by AMPK may block translocation to lipid droplets.	Belongs to the 'GDXG' lipolytic enzyme family.	Glycerolipid metabolism; triacylglycerol degradation.;Insulin signaling pathway;Triglyceride catabolism	PE1	19
+NX_Q05481	Zinc finger protein 91	1191	137217	9.45	0	Nucleus	NA	Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidence is required to confirm this result in vivo (PubMed:11470777).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q05513	Protein kinase C zeta type	592	67660	5.49	0	Cytoplasm;Cell membrane;Cell junction;Membrane;Endosome;Cytosol	NA	Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance.;Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).	CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the kinase.;PRKCZ is phosphorylated by PRKCQ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PRKCZ is phosphorylated by PAK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Chemokine signaling pathway;Endocytosis;Tight junction;Insulin signaling pathway;Type II diabetes mellitus;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);GPVI-mediated activation cascade;VEGFR2 mediated cell proliferation;RHO GTPases Activate NADPH Oxidases;Estrogen-stimulated signaling through PRKCZ	PE1	1
+NX_Q05516	Zinc finger and BTB domain-containing protein 16	673	74274	6.02	0	Nuclear body;Nucleus	Skeletal defects, genital hypoplasia, and mental retardation	Acts as a transcriptional repressor (PubMed:24359566). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	11
+NX_Q05519	Serine/arginine-rich splicing factor 11	484	53542	10.52	0	Nucleus speckle;Nucleus	NA	May function in pre-mRNA splicing.	NA	Belongs to the splicing factor SR family.	Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	1
+NX_Q05586	Glutamate receptor ionotropic, NMDA 1	938	105373	9.03	3	Postsynaptic cell membrane;Postsynaptic density;Cell membrane	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive;Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761).	NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.;GRIN1 is phosphorylated by EPHB2 (Phosphotyrosine:PTM-0255)	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Long-term potentiation;Glutamatergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Huntington's disease;RAF/MAP kinase cascade;EPHB-mediated forward signaling;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;Synaptic adhesion-like molecules;Neurexins and neuroligins;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	9
+NX_Q05639	Elongation factor 1-alpha 2	463	50470	9.11	0	Nucleus	Mental retardation, autosomal dominant 38;Epileptic encephalopathy, early infantile, 33	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.	Trimethylated at Lys-165 by EEF1AKMT3 (PubMed:28108655). Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs (PubMed:28520920). Trimethylated at the N-terminus by EEF1AKNMT (PubMed:30143613). Mono- and dimethylated at Lys-55 by EEF1AKNMT; dimethylated form is predominant (PubMed:30143613, PubMed:30612740).	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	RNA transport;Legionellosis;Eukaryotic Translation Elongation	PE1	20
+NX_Q05655	Protein kinase C delta type	676	77505	7.93	0	Golgi apparatus;Cytoplasm;Cell membrane;Endoplasmic reticulum;Cytosol;Perinuclear region;Nucleus	Autoimmune lymphoproliferative syndrome 3	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462).	Proteolytically cleaved into a catalytic subunit and a regulatory subunit by caspase-3 during apoptosis which results in kinase activation.;Autophosphorylated and/or phosphorylated at Thr-507, within the activation loop; phosphorylation at Thr-507 is not a prerequisite for enzymatic activity. Autophosphorylated at Ser-299, Ser-302 and Ser-304. Upon TNFSF10/TRAIL treatment, phosphorylated at Tyr-155; phosphorylation is required for its translocation to the endoplasmic reticulum and cleavage by caspase-3. Phosphorylated at Tyr-313, Tyr-334 and Tyr-567; phosphorylation of Tyr-313 and Tyr-567 following thrombin stimulation potentiates its kinase activity. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Chemokine signaling pathway;Vascular smooth muscle contraction;Tight junction;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Neurotrophin signaling pathway;GnRH signaling pathway;Type II diabetes mellitus;CLEC7A (Dectin-1) signaling;Interferon gamma signaling;Effects of PIP2 hydrolysis;SHC1 events in ERBB2 signaling;G alpha (z) signalling events;Apoptotic cleavage of cellular proteins;Role of phospholipids in phagocytosis;VEGFR2 mediated cell proliferation;HuR (ELAVL1) binds and stabilizes mRNA;RHO GTPases Activate NADPH Oxidases;Calmodulin induced events;DAG and IP3 signaling;Neutrophil degranulation	PE1	3
+NX_Q05682	Caldesmon	793	93231	5.62	0	Cell membrane;Stress fiber;Myofibril;Cytoskeleton	NA	Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).	In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).	Belongs to the caldesmon family.	Vascular smooth muscle contraction;Smooth Muscle Contraction	PE1	7
+NX_Q05707	Collagen alpha-1(XIV) chain	1796	193515	5.16	0	Cytoplasmic vesicle;Extracellular matrix	NA	Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.;May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding.;Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates.	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.	Protein digestion and absorption;Collagen degradation;Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	8
+NX_Q05823	2-5A-dependent ribonuclease	741	83533	6.2	0	Cytoplasm;Cytosol;Mitochondrion	Prostate cancer, hereditary, 1	Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.	NA	Belongs to the protein kinase superfamily.	Hepatitis C;Influenza A;Herpes simplex infection;Interferon alpha/beta signaling;OAS antiviral response	PE1	1
+NX_Q05901	Neuronal acetylcholine receptor subunit beta-3	458	52729	8.15	4	Postsynaptic cell membrane;Cell membrane	NA	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily.	Neuroactive ligand-receptor interaction;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly calcium permeable nicotinic acetylcholine receptors	PE2	8
+NX_Q05923	Dual specificity protein phosphatase 2	314	34400	8.24	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway;RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway	PE1	2
+NX_Q05925	Homeobox protein engrailed-1	392	40115	9.55	0	Nucleoplasm;Nucleus;Nucleolus	NA	NA	NA	Belongs to the engrailed homeobox family.	NA	PE1	2
+NX_Q05932	Folylpolyglutamate synthase, mitochondrial	587	64609	8.17	0	Cytoplasm;Mitochondrion matrix;Mitochondrion inner membrane	NA	Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.	NA	Belongs to the folylpolyglutamate synthase family.	Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.;Folate biosynthesis;Metabolic pathways;Metabolism of folate and pterines	PE1	9
+NX_Q05940	Synaptic vesicular amine transporter	514	55713	5.69	12	Cytoplasmic vesicle;Centrosome;Cytoplasmic vesicle membrane	Parkinsonism-dystonia, infantile, 2	Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed:23363473). Requisite for vesicular amine storage prior to secretion via exocytosis.	NA	Belongs to the major facilitator superfamily. Vesicular transporter family.	Synaptic vesicle cycle;Dopaminergic synapse;Parkinson's disease;Na+/Cl- dependent neurotransmitter transporters;Norepinephrine Neurotransmitter Release Cycle;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle	PE1	10
+NX_Q05952	Nuclear transition protein 2	138	15641	11.59	0	Nucleus;Chromosome	NA	Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.	NA	Belongs to the nuclear transition protein 2 family.	NA	PE1	16
+NX_Q05996	Zona pellucida sperm-binding protein 2	745	82357	6	1	Extracellular matrix;Cell membrane	Oocyte maturation defect 6	Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy (PubMed:29895852). The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (PubMed:29895852).	O-glycosylated; contains sulfate-substituted glycans.;N-glycosylated.;Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos.;Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.	Belongs to the ZP domain family. ZPA subfamily.	Interaction With Cumulus Cells And The Zona Pellucida	PE1	16
+NX_Q05BQ5	MBT domain-containing protein 1	628	70547	7.96	0	Nucleoplasm;Cytosol;Nucleus	NA	Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4.	NA	NA	NA	PE1	17
+NX_Q05BU3	Putative protein FAM86JP	40	4003	11.83	0	NA	NA	NA	NA	NA	NA	PE5	3
+NX_Q05BV3	Echinoderm microtubule-associated protein-like 5	1969	219427	7.87	0	Cytoskeleton	NA	May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.	NA	Belongs to the WD repeat EMAP family.	NA	PE1	14
+NX_Q05C16	Leucine-rich repeat-containing protein 63	580	66309	9.26	0	Golgi apparatus	NA	NA	NA	NA	NA	PE1	13
+NX_Q05D32	CTD small phosphatase-like protein 2	466	52999	6.03	0	Nucleoplasm	NA	Probable phosphatase.	NA	Belongs to the CTDSPL2 family.	NA	PE1	15
+NX_Q05D60	Deuterosome assembly protein 1	604	70977	5.87	0	Cytoplasm	NA	Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).	NA	Belongs to the CEP63 family.	NA	PE1	11
+NX_Q05DH4	Protein FAM160A1	1040	116621	4.76	0	Cytosol	NA	NA	NA	Belongs to the UPF0518 family.	NA	PE1	4
+NX_Q06033	Inter-alpha-trypsin inhibitor heavy chain H3	890	99849	5.49	0	Secreted	NA	May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.	Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.	Belongs to the ITIH family.	Platelet degranulation	PE1	3
+NX_Q06055	ATP synthase F(0) complex subunit C2, mitochondrial	141	14637	9.26	2	Mitochondrion membrane	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.	Trimethylated by ATPSCKMT at Lys-109. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.	Belongs to the ATPase C chain family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	12
+NX_Q06124	Tyrosine-protein phosphatase non-receptor type 11	597	68436	6.87	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Noonan syndrome 1;Metachondromatosis;LEOPARD syndrome 1;Leukemia, juvenile myelomonocytic	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).	Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.;PTPN11 is phosphorylated by JAK2;PTPN11 is phosphorylated by FGFR2;PTPN11 is phosphorylated by FGFR3;PTPN11 is phosphorylated by INSR	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.	Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Adipocytokine signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Herpes simplex infection;Renal cell carcinoma;Chronic myeloid leukemia;Interferon alpha/beta signaling;PD-1 signaling;PI3K Cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;FRS-mediated FGFR2 signaling;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;GPVI-mediated activation cascade;Regulation of IFNA signaling;Prolactin receptor signaling;Signaling by SCF-KIT;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;Interleukin-3, Interleukin-5 and GM-CSF signaling;Signal regulatory protein family interactions;Netrin mediated repulsion signals;PECAM1 interactions;CTLA4 inhibitory signaling;MAPK3 (ERK1) activation;Tie2 Signaling;Regulation of IFNG signaling;Spry regulation of FGF signaling;Platelet sensitization by LDL;Interleukin-6 signaling;Signaling by Leptin;Costimulation by the CD28 family;MAPK1 (ERK2) activation;Downstream signal transduction;GAB1 signalosome;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-20 family signaling;RET signaling;MET activates PTPN11;Regulation of RUNX1 Expression and Activity;Interleukin-37 signaling;Activated NTRK2 signals through FRS2 and FRS3;FLT3 Signaling;STAT5 Activation	PE1	12
+NX_Q06136	3-ketodihydrosphingosine reductase	332	36187	6.75	2	Endoplasmic reticulum membrane	Erythrokeratodermia variabilis et progressiva 4	Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis	PE1	18
+NX_Q06141	Regenerating islet-derived protein 3-alpha	175	19395	7.56	0	Secreted	NA	Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.	Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.	NA	Antimicrobial peptides	PE1	2
+NX_Q06187	Tyrosine-protein kinase BTK	659	76281	7.83	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	Growth hormone deficiency, isolated, 3, with agammaglobulinemia;X-linked agammaglobulinemia	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.	Following B-cell receptor (BCR) engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-551 by LYN and SYK. Phosphorylation at Tyr-551 is followed by autophosphorylation of Tyr-223 which may create a docking site for a SH2 containing protein. Phosphorylation at Ser-180 by PRKCB, leads in translocation of BTK back to the cytoplasmic fraction. Phosphorylation at Ser-21 and Ser-115 creates a binding site for PIN1 at these Ser-Pro motifs, and promotes it's recruitment.;BTK is phosphorylated by PRKCA (Phosphoserine:PTM-0253);BTK is phosphorylated by PRKCG (Phosphoserine:PTM-0253);BTK is phosphorylated by PRKCE (Phosphoserine:PTM-0253);BTK is phosphorylated by JAK1 (Phosphotyrosine:PTM-0255);BTK is phosphorylated by PRKCQ (Phosphoserine:PTM-0253);BTK is phosphorylated by PRKCB (Phosphoserine:PTM-0253);BTK is phosphorylated by PRKCZ (Phosphoserine:PTM-0253)	Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.	Osteoclast differentiation;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Primary immunodeficiency;ER-Phagosome pathway;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;G alpha (q) signalling events;DAP12 signaling;FCERI mediated Ca+2 mobilization;G alpha (12/13) signalling events;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;G beta:gamma signalling through BTK	PE1	X
+NX_Q06190	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha	1150	130278	5.09	0	Golgi apparatus	NA	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	NA	NA	mRNA surveillance pathway;Dopaminergic synapse	PE1	3
+NX_Q06203	Amidophosphoribosyltransferase	517	57399	6.3	0	Midbody ring	NA	NA	NA	In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.;Purine metabolism;Alanine, aspartate and glutamate metabolism;Metabolic pathways;Purine ribonucleoside monophosphate biosynthesis	PE1	4
+NX_Q06210	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	699	78806	6.66	0	Nucleoplasm;Nucleolus	Myasthenic syndrome, congenital, 12	Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.	NA	NA	Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.;Alanine, aspartate and glutamate metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;XBP1(S) activates chaperone genes;Synthesis of UDP-N-acetyl-glucosamine;Defective GFPT1 causes CMSTA1	PE1	2
+NX_Q06250	Putative Wilms tumor upstream neighbor 1 gene protein	92	10039	11.65	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q06265	Exosome complex component RRP45	439	48949	5.19	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	Pontocerebellar hypoplasia 1D	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.	NA	Belongs to the RNase PH family.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;mRNA decay by 3' to 5' exoribonuclease;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	4
+NX_Q06278	Aldehyde oxidase	1338	147918	6.79	0	Cytoplasm	NA	Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.	NA	Belongs to the xanthine dehydrogenase family.	Valine, leucine and isoleucine degradation;Tyrosine metabolism;Tryptophan metabolism;Vitamin B6 metabolism;Nicotinate and nicotinamide metabolism;Drug metabolism - cytochrome P450;Metabolic pathways;Vitamins B6 activation to pyridoxal phosphate	PE1	2
+NX_Q06323	Proteasome activator complex subunit 1	249	28723	5.78	0	Cytosol;Nucleus	NA	Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.	NA	Belongs to the PA28 family.	Proteasome;Antigen processing and presentation;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	14
+NX_Q06330	Recombining binding protein suppressor of hairless	500	55637	6.8	0	Cytoplasm;Nucleoplasm;Nucleus	Adams-Oliver syndrome 3	Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).	NA	Belongs to the Su(H) family.	Notch signaling pathway;Pre-NOTCH Transcription and Translation;Notch-HLH transcription pathway;NOTCH2 intracellular domain regulates transcription;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE1	4
+NX_Q06413	Myocyte-specific enhancer factor 2C	473	51221	8.14	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus;Sarcoplasm	Mental retardation, autosomal dominant 20	Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1.	Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.;Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity).;Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity.;Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity.	Belongs to the MEF2 family.	MAPK signaling pathway;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;ERK/MAPK targets;MECP2 regulates transcription factors;Myogenesis	PE1	5
+NX_Q06416	Putative POU domain, class 5, transcription factor 1B	359	38588	6.26	0	Nucleus	NA	Shows weak transcriptional activator activity.	NA	Belongs to the POU transcription factor family. Class-5 subfamily.	NA	PE5	8
+NX_Q06418	Tyrosine-protein kinase receptor TYRO3	890	96905	5.47	1	Cell membrane	NA	(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.;(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.;Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.	Autophosphorylated.;TYRO3 is phosphorylated by AXL (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);Autophosphorylated	Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.	NA	PE1	15
+NX_Q06432	Voltage-dependent calcium channel gamma-1 subunit	222	25028	6.64	4	Sarcolemma	NA	Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.	N-glycosylated.	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	17
+NX_Q06455	Protein CBFA2T1	604	67566	8.15	0	Nucleoplasm;Nucleus	NA	Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588).	NA	Belongs to the CBFA2T family.	NA	PE1	8
+NX_Q06481	Amyloid-like protein 2	763	86956	4.73	1	Cytoplasmic vesicle;Nucleus;Cell membrane	NA	May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).	The BPTI/Kunitz inhibitor domain is O-glycosylated.	Belongs to the APP family.	Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	11
+NX_Q06495	Sodium-dependent phosphate transport protein 2A	639	68937	8.99	8	Nucleus speckle;Cell membrane;Apical cell membrane;Nucleoplasm;Cytosol;Spindle	Hypercalcemia, infantile, 2;Fanconi renotubular syndrome 2;Nephrolithiasis/osteoporosis, hypophosphatemic, 1	Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.	NA	Belongs to the SLC34A transporter family.	Type II Na+/Pi cotransporters;Surfactant metabolism;Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)	PE1	5
+NX_Q06520	Bile salt sulfotransferase	285	33780	5.71	0	Cytoplasm;Cytosol	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.	The N-terminus is blocked.	Belongs to the sulfotransferase 1 family.	Metabolism of xenobiotics by cytochrome P450;Bile secretion;PPARA activates gene expression;Cytosolic sulfonation of small molecules	PE1	19
+NX_Q06546	GA-binding protein alpha chain	454	51295	4.87	0	Nucleoplasm;Nucleus	NA	Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.	NA	Belongs to the ETS family.	Transcriptional activation of mitochondrial biogenesis	PE1	21
+NX_Q06547	GA-binding protein subunit beta-1	395	42483	4.77	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.	NA	NA	Transcriptional activation of mitochondrial biogenesis	PE1	15
+NX_Q06587	E3 ubiquitin-protein ligase RING1	406	42429	5.44	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.	NA	NA	Protein modification; protein ubiquitination.;SUMOylation of DNA damage response and repair proteins;Oxidative Stress Induced Senescence;SUMOylation of RNA binding proteins;SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins	PE1	6
+NX_Q06609	DNA repair protein RAD51 homolog 1	339	36966	5.44	0	Cytoplasm;Mitochondrion matrix;Nucleolus;Chromosome;Centrosome;Cytosol;Perinuclear region;Nucleus	Breast cancer;Mirror movements 2;Fanconi anemia, complementation group R	Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).	Ubiquitinated by the SCF(FBH1) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. Ubiquitinated by RFWD3 in response to DNA damage: ubiquitination leads to degradation by the proteasome, promoting homologous recombination (PubMed:28575658).;Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.;RAD51 is phosphorylated by CHEK1	Belongs to the RecA family. RAD51 subfamily.	Homologous recombination;Fanconi anemia pathway;Pathways in cancer;Pancreatic cancer;Meiotic recombination;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Presynaptic phase of homologous DNA pairing and strand exchange;Transcriptional Regulation by E2F6	PE1	15
+NX_Q06643	Lymphotoxin-beta	244	25390	5.25	1	Membrane;Centrosome	NA	Is probably non-functional.;Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface.	NA	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;Rheumatoid arthritis;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	PE1	6
+NX_Q06710	Paired box protein Pax-8	450	48218	7.72	0	Nucleoplasm;Nucleus	Hypothyroidism, congenital, non-goitrous, 2	Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.	NA	NA	Pathways in cancer;Thyroid cancer	PE1	2
+NX_Q06730	Zinc finger protein 33A	810	94384	8.42	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	10
+NX_Q06732	Zinc finger protein 33B	778	90683	8.6	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	10
+NX_Q06787	Synaptic functional regulator FMR1	632	71174	7	0	Cajal body;Dendritic spine;Filopodium tip;Presynaptic cell membrane;Postsynaptic cell membrane;Growth cone;Cytosol;Dendrite;Cytoplasm;Cell membrane;Synaptosome;Synapse;Neuron projection;Stress granule;Chromosome;Axon;Perikaryon;Nucleolus;Centromere;Cytoplasmic ribonucleoprotein granule;Perinuclear region;Nucleus	Fragile X tremor/ataxia syndrome;Premature ovarian failure 1;Fragile X syndrome	Binds to RNA homopolymer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304).;Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs (PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Plays a role in mRNA nuclear export (By similarity). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postnyaptic dendritic spines (PubMed:11532944, PubMed:11157796, PubMed:12594214, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes (PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:14703574, PubMed:17057366, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (PubMed:17057366). Plays also a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:19097999, PubMed:19166269). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:7692601, PubMed:11719189, PubMed:11157796, PubMed:12594214, PubMed:17417632, PubMed:23235829, PubMed:24448548). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (PubMed:23235829). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:11719189, PubMed:18579868, PubMed:25464849, PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (PubMed:7692601, PubMed:11532944, PubMed:12594214, PubMed:15282548, PubMed:18653529). Binds also to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (PubMed:15805463). Binds mRNAs containing U-rich target sequences (PubMed:12927206). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain (PubMed:14703574, PubMed:17057366). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (PubMed:18936162). In vitro, binds to RNA homopolymer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:7688265, PubMed:7781595, PubMed:12950170, PubMed:15381419, PubMed:8156595). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteosomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Recently, has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). Finally, FMR1 may be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AFX/H2A.x and BRCA1 phosphorylations (PubMed:24813610).;(Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components.;Binds to RNA homopolymer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304).	Undergoes proteolytic cleavage; may be specifically cleaved by calpain-1/CAPN1 in cajal bodies (PubMed:24204304).;Methylated; methylation is necessary for heterodimerization with FXR1, association with polyribosomes, recruitment into stress granules and translation of FMR1 target mRNAs (PubMed:16636078). Methylated by PRMT1, PRMT3 and PRMT4, in vitro (PubMed:16922515).;Monoubiquitinated. Polyubiquitinated. Ubiquitinated and targeted for proteasomal degradation after activation of metabotropic glutamate receptor (mGluR).;Phosphorylated (PubMed:14532325). Phosphorylated on several serine residues. Phosphorylation at Ser-500 is required for phosphorylation of other nearby serine residues. Phosphorylation has no effect on the binding of individual mRNA species, but may affect the association with polyribosome. Unphosphorylated FMR1 is associated with actively translating polyribosome, whereas a fraction of phosphorylated FMR1 is associated with apparently stalled polyribosome. Dephosphorylation by an activated phosphatase may release the FMR1-mediated translational repression and allow synthesis of a locally required protein at snypases (By similarity).	Belongs to the FMR1 family.	NA	PE1	X
+NX_Q06828	Fibromodulin	376	43179	5.66	0	Extracellular matrix	NA	Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).	Binds keratan sulfate chains.	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Keratan sulfate biosynthesis;Defective CHST6 causes MCDC1;Keratan sulfate degradation;Defective B4GALT1 causes B4GALT1-CDG (CDG-2d);ECM proteoglycans;Defective ST3GAL3 causes MCT12 and EIEE15	PE1	1
+NX_Q06830	Peroxiredoxin-1	199	22110	8.27	0	Cytoplasm;Melanosome;Mitochondrion	NA	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).	The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.;Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.	Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.	Peroxisome;Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	PE1	1
+NX_Q06889	Early growth response protein 3	387	42613	8.62	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Probable transcription factor involved in muscle spindle development.	NA	Belongs to the EGR C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_Q06945	Transcription factor SOX-4	474	47263	6.87	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.	NA	NA	Deactivation of the beta-catenin transactivating complex	PE1	6
+NX_Q07001	Acetylcholine receptor subunit delta	517	58895	6.12	4	Postsynaptic cell membrane;Nucleoplasm;Cytosol;Cell membrane	Myasthenic syndrome, congenital, 3C, associated with acetylcholine receptor deficiency;Multiple pterygium syndrome, lethal type;Myasthenic syndrome, congenital, 3A, slow-channel;Myasthenic syndrome, congenital, 3B, fast-channel	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily.	Neuroactive ligand-receptor interaction;Highly sodium permeable acetylcholine nicotinic receptors	PE1	2
+NX_Q07002	Cyclin-dependent kinase 18	474	54424	8.84	0	Cytoskeleton	NA	May play a role in signal transduction cascades in terminally differentiated cells.	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	1
+NX_Q07011	Tumor necrosis factor receptor superfamily member 9	255	27899	8.12	1	Membrane;Nucleolus;Cell membrane	NA	Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.	NA	NA	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	1
+NX_Q07020	60S ribosomal protein L18	188	21634	11.73	0	Cytoplasm;Nucleolus;Rough endoplasmic reticulum;Endoplasmic reticulum;Cytosol;Nucleus	Diamond-Blackfan anemia 18	Component of the large ribosomal subunit.	RPL18 is phosphorylated by MAPK3	Belongs to the eukaryotic ribosomal protein eL18 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_Q07021	Complement component 1 Q subcomponent-binding protein, mitochondrial	282	31362	4.74	0	Cytoplasm;Mitochondrion;Cell membrane;Mitochondrion matrix;Secreted;Nucleolus;Nucleus	Combined oxidative phosphorylation deficiency 33	(Microbial infection) Involved in replication of Rubella virus.;(Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A.;(Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA.;Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection.	NA	Belongs to the MAM33 family.	Herpes simplex infection;Intrinsic Pathway of Fibrin Clot Formation	PE1	17
+NX_Q07065	Cytoskeleton-associated protein 4	602	66022	5.63	1	Endoplasmic reticulum membrane;Nucleus speckle;Cell membrane;Cytosol;Perinuclear region;Cytoskeleton	NA	High-affinity epithelial cell surface receptor for APF.;Mediates the anchoring of the endoplasmic reticulum to microtubules.	Increased phosphorylation during mitosis prevents binding to microtubules.;Reversibly palmitoylated. Palmitoylation at Cys-100 by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization.	NA	Protein processing in endoplasmic reticulum;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Surfactant metabolism;Neutrophil degranulation;Post-translational protein phosphorylation	PE1	12
+NX_Q07075	Glutamyl aminopeptidase	957	109244	5.31	1	Cell membrane	NA	Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.	NA	Belongs to the peptidase M1 family.	Renin-angiotensin system;Metabolism of Angiotensinogen to Angiotensins	PE1	4
+NX_Q07092	Collagen alpha-1(XVI) chain	1604	157751	8.14	0	Golgi apparatus;Cytosol;Extracellular matrix;Cell membrane	NA	Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.;Glycosylated.	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.	Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;Collagen chain trimerization	PE1	1
+NX_Q07108	Early activation antigen CD69	199	22559	6.16	1	Membrane	NA	Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.	Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.	NA	NA	PE1	12
+NX_Q07157	Tight junction protein ZO-1	1748	195459	6.24	0	Golgi apparatus;Cell membrane;Cell junction;Gap junction;Podosome;Tight junction	NA	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).	Phosphorylated at tyrosine redidues in response to epidermal growth factor (EGF) (PubMed:19332538, PubMed:7542259). This response is dependent on an intact actin microfilament system (PubMed:7542259). Dephosphorylated by PTPRJ (PubMed:19332538).	Belongs to the MAGUK family.	Adherens junction;Tight junction;Gap junction;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Salmonella infection;Signaling by Hippo;Apoptotic cleavage of cell adhesion proteins;RUNX1 regulates expression of components of tight junctions;Regulation of gap junction activity	PE1	15
+NX_Q07283	Trichohyalin	1943	253925	5.73	0	NA	Uncombable hair syndrome 3	Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.	Substrate of transglutaminase. Some 200 arginines are probably converted to citrullines by peptidylarginine deimidase.	Belongs to the S100-fused protein family.	Formation of the cornified envelope	PE1	1
+NX_Q07325	C-X-C motif chemokine 9	125	14019	10.39	0	Secreted	NA	Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.	NA	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Toll-like receptor signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	4
+NX_Q07326	Phosphatidylinositol-glycan biosynthesis class F protein	219	24890	8.88	6	Endoplasmic reticulum membrane	NA	Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI.	NA	Belongs to the PIGF family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	2
+NX_Q07343	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	736	83343	5.09	0	Golgi apparatus;Cytosol	NA	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.;Purine metabolism;DARPP-32 events	PE1	1
+NX_Q07352	mRNA decay activator protein ZFP36L1	338	36314	8.12	0	Cytoplasm;P-body;Cytoplasmic granule;Nucleus	NA	Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).	Ubiquitinated. Ubiquitination leads to proteasomal degradation, a process inhibited by phosphorylations at Ser-90, Ser-92 and Ser-203 (PubMed:17030608).;Phosphorylated (PubMed:19179481). Phosphorylated by RPS6KA1 at Ser-334 upon phorbol 12-myristate 13-acetate (PMA) treatment; this phosphorylation results in dissociation of the CCR4-NOT deadenylase complex and induces p38 MAPK-mediated stabilization of the low-density lipoprotein receptor LDLR mRNA (PubMed:25106868). Phosphorylated by protein kinase AKT1 at Ser-92 and Ser-203 in response to insulin; these phosphorylations stabilize ZFP36L1, increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization (PubMed:15538381, PubMed:17030608). AKT1-mediated phosphorylation at Ser-92 does not impair ARE-containing RNA-binding (PubMed:15538381). Phosphorylated at Ser-54, Ser-92 and Ser-203 by MAPKAPK2; these phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization in a protein kinase AKT1-independent manner (PubMed:18326031). MAPKAPK2-mediated phosphorylations at Ser-54, Ser-92 and Ser-203 do not impair ARE-containing RNA-binding (PubMed:18326031). Phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization during early adipogenesis in a p38 MAPK- and AKT-dependent manner (By similarity).	NA	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	PE1	14
+NX_Q07444	NKG2-E type II integral membrane protein	240	27100	8.36	1	Membrane;Cytoplasmic vesicle	NA	Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	NA	NA	Antigen processing and presentation;Natural killer cell mediated cytotoxicity	PE2	12
+NX_Q07507	Dermatopontin	201	24005	4.7	0	Cytoplasmic vesicle;Extracellular matrix	NA	Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).	Sulfated on tyrosine residue(s).	Belongs to the dermatopontin family.	NA	PE1	1
+NX_Q075Z2	Binder of sperm protein homolog 1	132	15693	6.8	0	Secreted	NA	Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B.	NA	Belongs to the seminal plasma protein family.	NA	PE1	19
+NX_Q07617	Sperm-associated antigen 1	926	103639	6.46	0	Cytoplasm;Cytosol	Ciliary dyskinesia, primary, 28	May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity.	NA	NA	NA	PE1	8
+NX_Q07627	Keratin-associated protein 1-1	177	18235	5.55	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 1 family.	Keratinization	PE1	17
+NX_Q07654	Trefoil factor 3	94	10181	6.52	0	Nucleoplasm;Cytoplasm;Extracellular matrix;Nucleolus	NA	Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).	NA	NA	Estrogen-dependent gene expression	PE1	21
+NX_Q07666	KH domain-containing, RNA-binding, signal transduction-associated protein 1	443	48227	8.73	0	Membrane;Cytoplasm;Nucleoplasm;Nucleus	NA	Which is expressed in growth-arrested cells only, inhibits S phase.;Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity).	Acetylated. Positively correlates with ability to bind RNA.;Arginine methylation is required for nuclear localization. Also can affect interaction with other proteins. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 AND FNBP4/FBP30.;Tyrosine phosphorylated by several non-receptor tyrosine kinases including LCK, FYN and JAK3. Also tyrosine phosphorylated by the non-receptor tyrosine kinase SRMS in an EGF-dependent manner (PubMed:29496907). Negatively correlates with ability to bind RNA but required for many interactions with proteins. Phosphorylation by PTK6 negatively regulates its RNA binding ability. Phosphorylation by PTK6 at Tyr-440 dictates the nuclear localization of KHDRBS1. Phosphorylation at Tyr-387 disrupts interaction with APC. Phosphorylation at tyrosine residues by FYN inverts activity on modulation of BCL2L1 alternative splicing.;KHDRBS1 is phosphorylated by SRC	Belongs to the KHDRBS family.	PTK6 Regulates Proteins Involved in RNA Processing	PE1	1
+NX_Q07687	Homeobox protein DLX-2	328	34243	9.25	0	Nucleus speckle;Nucleus	NA	Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.	NA	Belongs to the distal-less homeobox family.	NA	PE1	2
+NX_Q07699	Sodium channel subunit beta-1	218	24707	4.88	1	Cell membrane;Perikaryon;Secreted;Cell projection;Axon	Epileptic encephalopathy, early infantile, 52;Atrial fibrillation, familial, 13;Brugada syndrome 5;Generalized epilepsy with febrile seizures plus 1	Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth (PubMed:21994374). Has no regulatory function on the SCN2A sodium channel complex (PubMed:14622265).;Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.	NA	Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	19
+NX_Q07812	Apoptosis regulator BAX	192	21184	5.08	1	Mitochondrion outer membrane;Cytoplasm	NA	Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.	NA	Belongs to the Bcl-2 family.	p53 signaling pathway;Protein processing in endoplasmic reticulum;Apoptosis;Neurotrophin signaling pathway;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Prion diseases;Tuberculosis;HTLV-I infection;Pathways in cancer;Colorectal cancer;Release of apoptotic factors from the mitochondria;Activation, translocation and oligomerization of BAX;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Transcriptional regulation by RUNX2;NTRK3 as a dependence receptor	PE1	19
+NX_Q07817	Bcl-2-like protein 1	233	26049	4.86	1	Mitochondrion outer membrane;Mitochondrion;Mitochondrion matrix;Nucleus membrane;Synaptic vesicle membrane;Centrosome;Cytosol;Mitochondrion inner membrane	NA	Promotes apoptosis.;Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.;Also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).	Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis.;Ubiquitinated by RNF183 during prolonged ER stress, leading to degradation by the proteosome.;Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.	Belongs to the Bcl-2 family.	Apoptosis;Jak-STAT signaling pathway;Amyotrophic lateral sclerosis (ALS);Toxoplasmosis;HTLV-I infection;Pathways in cancer;Pancreatic cancer;Chronic myeloid leukemia;Small cell lung cancer;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;The NLRP1 inflammasome;Interleukin-4 and Interleukin-13 signaling	PE1	20
+NX_Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	350	37337	5.51	1	Membrane;Cytoplasm;Nucleoplasm;Mitochondrion	NA	Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.;Promotes apoptosis.;Inhibits apoptosis.	Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.;Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.;Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.;Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.;MCL1 is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the Bcl-2 family.	Interleukin-4 and Interleukin-13 signaling	PE1	1
+NX_Q07837	Neutral and basic amino acid transport protein rBAT	685	78852	5.61	1	Membrane;Mitochondrion;Nucleus	Cystinuria;Hypotonia-cystinuria syndrome	Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule.	NA	NA	Protein digestion and absorption;Amino acid transport across the plasma membrane;Defective SLC3A1 causes cystinuria (CSNU);Defective SLC7A9 causes cystinuria (CSNU)	PE1	2
+NX_Q07864	DNA polymerase epsilon catalytic subunit A	2286	261518	5.98	0	Nucleoplasm;Nucleus;Cell membrane	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency;Facial dysmorphism, immunodeficiency, livedo, and short stature;Colorectal cancer 12	Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication (By similarity). It is also involved in DNA synthesis during DNA repair (PubMed:27573199).	NA	Belongs to the DNA polymerase type-B family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;HTLV-I infection;Activation of the pre-replicative complex;Termination of translesion DNA synthesis;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Telomere C-strand synthesis initiation;DNA replication initiation;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER	PE1	12
+NX_Q07866	Kinesin light chain 1	573	65310	5.87	0	Cell membrane;Growth cone;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Cytoskeleton	NA	Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.	NA	Belongs to the kinesin light chain family.	Salmonella infection;MHC class II antigen presentation;Kinesins;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic	PE1	14
+NX_Q07869	Peroxisome proliferator-activated receptor alpha	468	52225	5.86	0	Nucleoplasm;Nucleus	NA	Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.	PPARA is phosphorylated by CDK7	Belongs to the nuclear hormone receptor family. NR1 subfamily.	PPAR signaling pathway;Adipocytokine signaling pathway;Hepatitis C;PPARA activates gene expression;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Nuclear Receptor transcription pathway;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);SUMOylation of intracellular receptors	PE1	22
+NX_Q07889	Son of sevenless homolog 1	1333	152464	6.38	0	Cytosol	Noonan syndrome 4;Fibromatosis, gingival, 1	Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).	Phosphorylation at Ser-1134 and Ser-1161 by RPS6KA3 create YWHAB and YWHAE binding sites and which contribute to the negative regulation of EGF-induced MAPK1/3 phosphorylation.	NA	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Dorso-ventral axis formation;Focal adhesion;Gap junction;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Neurotrophin signaling pathway;Regulation of actin cytoskeleton;Insulin signaling pathway;GnRH signaling pathway;Hepatitis C;Pathways in cancer;Renal cell carcinoma;Endometrial cancer;Glioma;Prostate cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;RAF/MAP kinase cascade;SHC-mediated cascade:FGFR1;FRS-mediated FGFR1 signaling;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;Role of LAT2/NTAL/LAB on calcium mobilization;Interleukin receptor SHC signaling;Rho GTPase cycle;NRAGE signals death through JNK;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;G alpha (12/13) signalling events;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;GRB2 events in ERBB2 signaling;EGFR Transactivation by Gastrin;Signaling by SCF-KIT;Regulation of KIT signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;NCAM signaling for neurite out-growth;Signal attenuation;Insulin receptor signalling cascade;Tie2 Signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Signalling to RAS;Activation of RAC1;SOS-mediated signalling;Downstream signal transduction;Constitutive Signaling by EGFRvIII;Signaling by FGFR4 in disease;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;SHC-related events triggered by IGF1R;GRB2:SOS provides linkage to MAPK signaling for Integrins;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR3 fusions in cancer;RET signaling;MET activates RAS signaling;Interleukin-15 signaling;Activated NTRK2 signals through RAS;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK3 signals through RAS;Erythropoietin activates RAS;FLT3 Signaling	PE1	2
+NX_Q07890	Son of sevenless homolog 2	1332	152979	6.39	0	Cytoplasmic vesicle;Nucleoplasm	Noonan syndrome 9	Promotes the exchange of Ras-bound GDP by GTP.	NA	NA	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Dorso-ventral axis formation;Focal adhesion;Gap junction;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Neurotrophin signaling pathway;Regulation of actin cytoskeleton;Insulin signaling pathway;GnRH signaling pathway;Hepatitis C;Pathways in cancer;Renal cell carcinoma;Endometrial cancer;Glioma;Prostate cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;Activation of RAC1;Interleukin-15 signaling	PE1	14
+NX_Q07912	Activated CDC42 kinase 1	1038	114569	6.84	0	Clathrin-coated vesicle;Cell membrane;Adherens junction;Clathrin-coated pit;Cytoplasmic vesicle membrane;Endosome;Cytosol;Perinuclear region;Nucleus	NA	Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370).	Polyubiquitinated by NEDD4 and NEDD4L. Degradation can be induced by EGF and is lysosome-dependent (By similarity).;Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-518 is required for interaction with SRC and is observed during association with clathrin-coated pits.;TNK2 is phosphorylated by HCK (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family.	NA	PE1	3
+NX_Q07954	Prolow-density lipoprotein receptor-related protein 1	4544	504606	5.16	1	Cytoplasm;Cell membrane;Coated pit;Nucleoplasm;Cytoplasmic vesicle;Nucleus	Keratosis pilaris atrophicans	(Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.;Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).	Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.;The N-terminus is blocked.;Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.;Phosphorylated on serine and threonine residues.	Belongs to the LDLR family.	Alzheimer's disease;Malaria;Retinoid metabolism and transport;Scavenging of heme from plasma	PE1	12
+NX_Q07955	Serine/arginine-rich splicing factor 1	248	27745	10.37	0	Cytoplasm;Nucleoplasm;Nucleus speckle	NA	Act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.;Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing.	Asymmetrically dimethylated at arginines, probably by PRMT1, methylation promotes localization to nuclear speckles.;Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Phosphorylated by SRPK1 at multiple serines in its RS domain via a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds to a docking groove in the large lobe of the kinase domain of SRPK1 and this induces certain structural changes in SRPK1 and/or RRM 2 domain of SRSF1, allowing RRM 2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM 2, which then docks at the docking groove of SRPK1. This also signals RRM 2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed.;SRSF1 is phosphorylated by SRPK1 (Phosphoserine:PTM-0253);SRSF1 is phosphorylated by PRKACA;SRSF1 is phosphorylated by SRPK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRSF1 is phosphorylated by CLK4 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRSF1 is phosphorylated by SRPK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRSF1 is phosphorylated by CLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the splicing factor SR family.	Spliceosome;Herpes simplex infection;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	17
+NX_Q07960	Rho GTPase-activating protein 1	439	50436	5.85	0	Cytoplasm;Cytoplasmic vesicle	NA	GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.	NA	NA	Rho GTPase cycle	PE1	11
+NX_Q07973	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	514	58875	8.94	0	Nucleoplasm;Mitochondrion;Cell membrane	Hypercalcemia, infantile, 1	Has a role in maintaining calcium homeostasis. Catalyzes the adrenodoxin-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.	NA	Belongs to the cytochrome P450 family.	Vitamin D (calciferol) metabolism;Vitamins;Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)	PE1	20
+NX_Q08043	Alpha-actinin-3	901	103241	5.37	0	NA	NA	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.	NA	Belongs to the alpha-actinin family.	Focal adhesion;Adherens junction;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Amoebiasis;Systemic lupus erythematosus;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Striated Muscle Contraction;Nephrin family interactions	PE1	11
+NX_Q08050	Forkhead box protein M1	763	84283	8	0	Nucleoplasm;Nucleolus;Cytosol;Nucleus	NA	Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.	Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators.	NA	Polo-like kinase mediated events;Cyclin A/B1/B2 associated events during G2/M transition	PE1	12
+NX_Q08116	Regulator of G-protein signaling 1	209	23858	8.8	0	Cytosol;Cell membrane	NA	Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).	NA	NA	G alpha (i) signalling events;G alpha (q) signalling events	PE1	1
+NX_Q08117	TLE family member 5	197	21970	5.9	0	Nucleoplasm;Nucleus	NA	Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.	Ubiquitinated by XIAP/BIRC4.	Belongs to the WD repeat Groucho/TLE family.	Repression of WNT target genes	PE1	19
+NX_Q08170	Serine/arginine-rich splicing factor 4	494	56678	11.52	0	Nucleus speckle	NA	Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.	Extensively phosphorylated on serine residues in the RS domain.;SRSF4 is phosphorylated by SRPK1 (Phosphoserine:PTM-0253)	Belongs to the splicing factor SR family.	Spliceosome;Herpes simplex infection;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	1
+NX_Q08174	Protocadherin-1	1060	114743	4.91	1	Nucleoplasm;Cell junction;Nucleolus;Cell membrane	NA	May be involved in cell-cell interaction processes and in cell adhesion.	NA	NA	NA	PE1	5
+NX_Q08188	Protein-glutamine gamma-glutamyltransferase E	693	76632	5.62	0	Cytoplasm	Uncombable hair syndrome 2	Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.	Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471 (PubMed:8099584) or between Pro-465 and Phe-466 (PubMed:16565075). Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS, but not by CTSB, CTSD nor CTSV (PubMed:16565075).	Belongs to the transglutaminase superfamily. Transglutaminase family.	NA	PE1	20
+NX_Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	521	58688	5.58	0	Cytoplasm;Dendritic spine;Cell membrane;Nucleoplasm;Cytosol;Z line;Sarcolemma	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development;Epileptic encephalopathy, infantile or early childhood, 1	Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:23468591, PubMed:27974827, PubMed:22343722). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118).	PPP3CA is phosphorylated by CAMK2D (Phosphoserine:PTM-0253)	Belongs to the PPP phosphatase family. PP-2B subfamily.	MAPK signaling pathway;Calcium signaling pathway;Oocyte meiosis;Apoptosis;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Osteoclast differentiation;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Long-term potentiation;Glutamatergic synapse;Dopaminergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Tuberculosis;HTLV-I infection;FCERI mediated Ca+2 mobilization;DARPP-32 events;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation;Calcineurin activates NFAT	PE1	4
+NX_Q08211	ATP-dependent RNA helicase A	1270	140958	6.41	0	Cytoplasm;Nucleolus;Nucleoplasm;Centrosome;Nucleus	NA	Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:9111062, PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:25062910, PubMed:24990949, PubMed:28221134). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:9111062, PubMed:10198287). Binds also to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11149922, PubMed:9323138, PubMed:9662397, PubMed:11038348, PubMed:11416126, PubMed:15355351, PubMed:28221134). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Acts also as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:9162007, PubMed:10924507, PubMed:11402034). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588).;(Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:9892698, PubMed:11096080). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Plays also a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886).	Phosphorylated by PRKDC; phosphorylation occurs in a RNA-dependent manner (PubMed:14704337). Phosphorylated by EIF2AK2/PKR; this phosphorylation reduces its association with double-stranded RNA (PubMed:19229320).;Methylated (PubMed:15084609). PRMT1-mediated methylation of undefined Arg residues in the RGG region is required for nuclear import of DHX9 (PubMed:15084609).	Belongs to the DEAD box helicase family. DEAH subfamily.	mRNA Splicing - Major Pathway;RIP-mediated NFkB activation via ZBP1;DEx/H-box helicases activate type I IFN and inflammatory cytokines production	PE1	1
+NX_Q08257	Quinone oxidoreductase	329	35207	8.56	0	Cytoplasm;Cytosol	NA	Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.	NA	PE1	1
+NX_Q08289	Voltage-dependent L-type calcium channel subunit beta-2	660	73581	8.11	0	Spindle;Sarcolemma;Cytoskeleton	Brugada syndrome 4	The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.	Regulated through phosphorylation at Thr-554 by CaMK2D.;CACNB2 is phosphorylated by CAMK2D (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the calcium channel beta subunit family.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;NCAM1 interactions;Adrenaline,noradrenaline inhibits insulin secretion;Presynaptic depolarization and calcium channel opening;Regulation of insulin secretion;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	10
+NX_Q08334	Interleukin-10 receptor subunit beta	325	36995	5.03	1	Membrane;Cytosol	Inflammatory bowel disease 25	Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.	NA	Belongs to the type II cytokine receptor family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Toxoplasmosis;Tuberculosis;Interleukin-20 family signaling;Interleukin-10 signaling;Other interleukin signaling	PE1	21
+NX_Q08345	Epithelial discoidin domain-containing receptor 1	913	101128	6.38	1	Nucleoplasm;Cell junction;Secreted;Cell membrane	NA	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.	Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.;Autophosphorylated in response to fibrillar collagen binding.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	Non-integrin membrane-ECM interactions	PE1	6
+NX_Q08357	Sodium-dependent phosphate transporter 2	652	70392	6.09	12	Cytoplasm;Cell membrane	Basal ganglia calcification, idiopathic, 1	Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not significantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.	NA	Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.	Sodium-coupled phosphate cotransporters;Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	PE1	8
+NX_Q08378	Golgin subfamily A member 3	1498	167355	5.34	0	Golgi stack membrane;Nucleoplasm;Golgi apparatus;Cytoplasm	NA	Golgi auto-antigen; probably involved in maintaining Golgi structure.	Cleaved by caspases in apoptotic cells.	NA	NA	PE1	12
+NX_Q08379	Golgin subfamily A member 2	1002	113086	5	0	Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment membrane;Spindle pole;cis-Golgi network membrane	NA	Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).	Cleaved by caspases at the onset of apoptosis.;Phosphorylated at Ser-37 by CDK1 at the onset of mitosis, inhibiting the interaction with p115/USO1 and triggering Golgi disassembly (PubMed:20421892, PubMed:26165940). Phosphorylated at Ser-37 in prophase as the Golgi complex starts to break down, and remains phosphorylated during further breakdown and partitioning of the Golgi fragments in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble (By similarity).;Methylation by PRMT5 is required for Golgi ribbon formation. While dimethylation at Arg-30 and Arg-35 are confirmed in vivo, it is unclear whether Arg-18 is methylated in vivo.	Belongs to the GOLGA2 family.	Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	PE1	9
+NX_Q08380	Galectin-3-binding protein	585	65331	5.13	0	Extracellular matrix;Secreted	NA	Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.	NA	NA	Platelet degranulation	PE1	17
+NX_Q08397	Lysyl oxidase homolog 1	574	63110	7.25	0	Endoplasmic reticulum;Extracellular space	Exfoliation syndrome	Active on elastin and collagen substrates.	The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.	Belongs to the lysyl oxidase family.	Elastic fibre formation;Crosslinking of collagen fibrils	PE1	15
+NX_Q08426	Peroxisomal bifunctional enzyme	723	79495	9.24	0	Peroxisome	Fanconi renotubular syndrome 3	NA	Acetylated, leading to enhanced enzyme activity. Acetylation is enhanced by up to 80% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with highest increase on Lys-346. Acetylation and enzyme activity increased by about 1.5% on addition of fatty acids.	In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.;In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Lysine degradation;Tryptophan metabolism;beta-Alanine metabolism;Propanoate metabolism;Butanoate metabolism;Metabolic pathways;PPAR signaling pathway;Peroxisome;Beta-oxidation of very long chain fatty acids;Peroxisomal protein import	PE1	3
+NX_Q08431	Lactadherin	387	43105	8.47	0	Cytoplasm;Secreted;Membrane;Cytosol;Nucleus	NA	Medin is the main constituent of aortic medial amyloid.;Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.	Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.	NA	Amyloid fiber formation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	15
+NX_Q08462	Adenylate cyclase type 2	1091	123603	8.4	12	Membrane;Cytoplasm;Cell membrane	NA	Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).	Phosphorylated by RAF1.	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Calcium signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;HTLV-I infection;Dilated cardiomyopathy;G alpha (i) signalling events;G alpha (s) signalling events;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G alpha (z) signalling events;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway	PE1	5
+NX_Q08477	Cytochrome P450 4F3	520	59847	7.57	1	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:8486631, PubMed:9675028, PubMed:11461919, PubMed:15145985, PubMed:16547005, PubMed:16820285, PubMed:18182499, PubMed:18065749, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). May play a role in inactivation of proinflammatory and anti-inflammatory oxylipins during the resolution of inflammation (PubMed:8486631, PubMed:9675028, PubMed:11461919, PubMed:15145985, PubMed:15364545, PubMed:16547005, PubMed:16820285, PubMed:18182499, PubMed:18065749, PubMed:18577768).;Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of oxylipins in myeloid cells, displaying higher affinity for arachidonate metabolite leukotriene B4 (LTB4) (PubMed:8486631, PubMed:9675028, PubMed:11461919, PubMed:15364545). Inactivates LTB4 via three successive oxidative transformations to 20-hydroxy-LTB4, then to 20-oxo-LTB4 and to 20-carboxy-LTB4 (PubMed:9675028). Exhibits omega-hydroxylase activity toward long-chain fatty acid epoxides with preference for 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (EET) and 9,10-epoxyoctadecanoate (PubMed:15145985). Omega-hydroxylates monohydroxy polyunsaturated fatty acids (PUFAs), including hydroxyeicosatetraenoates (HETEs) and hydroxyeicosapentaenoates (HEPEs), to dihydroxy compounds (PubMed:15364545, PubMed:9675028). Contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Has low hydroxylase activity toward PUFAs (PubMed:18577768, PubMed:11461919).;Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of polyunsaturated fatty acids (PUFAs) (PubMed:11461919, PubMed:16820285, PubMed:18577768). Participates in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:11461919, PubMed:16820285, PubMed:18577768). Exhibits high omega-hydroxylase activity toward other PUFAs, including eicosatrienoic acid (ETA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (PubMed:16820285, PubMed:18577768). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of PUFAs with lower efficiency (PubMed:18577768). Contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid and hexacosanoic acid, by catalyzing successive omega-oxidations and to the corresponding dicarboxylic acids, thereby initiating chain shortening (PubMed:16547005, PubMed:18182499). Omega-hydroxylates long-chain 3-hydroxy fatty acids, likely initiating the oxidative conversion to the corresponding 3-hydroxydicarboxylic fatty acids (PubMed:18065749). Has omega-hydroxylase activity toward long-chain fatty acid epoxides with preference for 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (EET) and 9,10-epoxyoctadecanoate (PubMed:15145985). Has lower affinity for leukotriene B4 (LTB4) compared with CYP4F3A, yet may contribute to the inactivation of LTB4 in liver (PubMed:15145985).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; arachidonate metabolism.;Lipid metabolism; leukotriene B4 degradation.;Arachidonic acid metabolism;Metabolic pathways;Miscellaneous substrates;Fatty acids;Eicosanoids;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	19
+NX_Q08493	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	712	79902	5.06	0	Cilium	NA	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.;Purine metabolism;G alpha (s) signalling events;DARPP-32 events	PE1	19
+NX_Q08495	Dematin	405	45514	8.94	0	Cytoplasm;Cell membrane;Endomembrane system;Cell projection;Membrane;Cytosol;Perinuclear region;Cytoskeleton	NA	Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.	The N-terminus is blocked.;Phosphorylated. Phosphorylation at Ser-403 by PKA causes the C-terminal headpiece domain to associate with the N-terminal core domain, and leads to the inhibition of its actin bundling activity.	Belongs to the villin/gelsolin family.	Miscellaneous transport and binding events	PE1	8
+NX_Q08499	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	809	91115	5.31	0	Cytoplasm;Cell membrane;Membrane;Centrosome;Cytosol;Apical cell membrane;Cytoskeleton	Acrodysostosis 2, with or without hormone resistance	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.	Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation.;Are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59.;Are activated by phosphorylation (in vitro), but not isoform 6.;Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation (By similarity).	Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.;Purine metabolism;G alpha (s) signalling events;DARPP-32 events	PE1	5
+NX_Q08554	Desmocollin-1	894	99987	5.25	1	Desmosome;Cell membrane	NA	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.	NA	NA	Neutrophil degranulation;Formation of the cornified envelope;Keratinization	PE1	18
+NX_Q08623	Pseudouridine-5'-phosphatase	228	25249	5.18	0	NA	NA	Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine.	NA	Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.	Pyrimidine salvage	PE1	X
+NX_Q08629	Testican-1	439	49124	5.74	0	Cytoplasmic vesicle;Extracellular matrix	NA	May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.	O-glycosylated. Glycosaminoglycan that contains chondroitin sulfate and heparan sulfate.	NA	NA	PE1	5
+NX_Q08648	Sperm-associated antigen 11B	103	11431	11.49	0	Secreted	NA	May have antimicrobial activity. May also play a role sperm maturation, storage, and protection.	NA	Belongs to the SPAG11 family.	NA	PE1	8
+NX_Q08708	CMRF35-like molecule 6	224	24830	9.38	1	Golgi apparatus;Mitochondrion;Cell membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the CD300 family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	17
+NX_Q08722	Leukocyte surface antigen CD47	323	35214	6.82	5	Cytoplasmic vesicle;Cell membrane	NA	Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.	NA	NA	ECM-receptor interaction;Integrin cell surface interactions;Cell surface interactions at the vascular wall;Signal regulatory protein family interactions;Neutrophil degranulation	PE1	3
+NX_Q08752	Peptidyl-prolyl cis-trans isomerase D	370	40764	6.77	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleolus	NA	(Microbial infection) May be involved in hepatitis C virus (HCV) replication and release.;PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines.	NA	Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.	Calcium signaling pathway;Parkinson's disease;Huntington's disease;ESR-mediated signaling	PE1	4
+NX_Q08828	Adenylate cyclase type 1	1119	123440	8.77	12	Cytoplasm;Mitochondrion;Cell membrane;Membrane;Membrane raft	Deafness, autosomal recessive, 44	Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).	N-glycosylated.	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Calcium signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;Chagas disease (American trypanosomiasis);Amoebiasis;HTLV-I infection;G alpha (i) signalling events;G alpha (s) signalling events;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G alpha (z) signalling events;CREB1 phosphorylation through the activation of Adenylate Cyclase;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway	PE1	7
+NX_Q08830	Fibrinogen-like protein 1	312	36379	5.58	0	Secreted	NA	Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).	NA	NA	NA	PE1	8
+NX_Q08881	Tyrosine-protein kinase ITK/TSK	620	71831	7.51	0	Cytoplasm;Nucleus	Lymphoproliferative syndrome 1	Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity).	Phosphorylated at Tyr-512 in the activation loop of the kinase domain by LCK. Subsequent autophosphorylation at Tyr-180 leads to the kinase activation. The autophosphorylated Tyr-180 lies within the substrate binding sequence of the SH3 domain.;Ubiquitinated.;ITK is phosphorylated by PRKCG (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254);ITK is phosphorylated by PRKCB (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254);ITK is phosphorylated by PRKCA (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254)	Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.	Chemokine signaling pathway;T cell receptor signaling pathway;Leukocyte transendothelial migration;Generation of second messenger molecules;FCERI mediated Ca+2 mobilization	PE1	5
+NX_Q08945	FACT complex subunit SSRP1	709	81075	6.45	0	Nucleolus;Chromosome;Nucleoplasm;Cytosol;Nucleus	NA	Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.	Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity.;Ubiquitinated. Polyubiquitinated following caspase cleavage resulting in degradation of the N-terminal ubiquitinated part of the cleaved protein.;Sumoylated.	Belongs to the SSRP1 family.	Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation	PE1	11
+NX_Q08999	Retinoblastoma-like protein 2	1139	128367	7.27	0	Nucleoplasm;Nucleus;Nucleolus;Cytosol	NA	Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.	During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.	Belongs to the retinoblastoma protein (RB) family.	Cell cycle;TGF-beta signaling pathway;G0 and Early G1;G1/S-Specific Transcription;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry;Cyclin D associated events in G1;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;FOXO-mediated transcription of cell cycle genes	PE1	16
+NX_Q08AD1	Calmodulin-regulated spectrin-associated protein 2	1489	168089	6.36	0	Golgi apparatus;Cytosol;Cytoskeleton	NA	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242).	NA	Belongs to the CAMSAP1 family.	NA	PE1	1
+NX_Q08AE8	Protein spire homolog 1	756	85544	8.89	0	Cell membrane;Cytoplasmic vesicle membrane;Endosome;Nucleoplasm;Cytosol;Perinuclear region;Cytoskeleton	NA	Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).	NA	Belongs to the spire family.	Dorso-ventral axis formation	PE1	18
+NX_Q08AF3	Schlafen family member 5	891	101055	8.54	0	Cytoplasmic vesicle;Nucleoplasm	NA	May have a role in hematopoietic cell differentiation.	NA	Belongs to the Schlafen family. Subgroup III subfamily.	NA	PE1	17
+NX_Q08AF8	Putative golgin subfamily A member 8F/8G	430	48405	5.41	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE5	15
+NX_Q08AG5	Zinc finger protein 844	666	76934	9.14	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q08AG7	Mitotic-spindle organizing protein 1	82	8479	4.76	0	Spindle;Centrosome	NA	Required for gamma-tubulin complex recruitment to the centrosome.	NA	Belongs to the MOZART1 family.	Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes	PE1	13
+NX_Q08AH1	Acyl-coenzyme A synthetase ACSM1, mitochondrial	577	65273	8.54	0	Mitochondrion matrix;Mitochondrion	NA	Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065). Capable of activating medium-chain fatty acids (e.g. Butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. Benzoate (PubMed:10434065). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Butanoate metabolism;Metabolic pathways;Conjugation of benzoate with glycine;Conjugation of phenylacetate with glutamine	PE1	16
+NX_Q08AH3	Acyl-coenzyme A synthetase ACSM2A, mitochondrial	577	64223	8.34	0	Mitochondrion	NA	Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. Butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. Benzoate (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Butanoate metabolism;Metabolic pathways;Conjugation of salicylate with glycine	PE1	16
+NX_Q08AI6	Putative sodium-coupled neutral amino acid transporter 11	406	44825	6.12	10	Membrane	NA	Putative sodium-dependent amino acid/proton antiporter.	NA	Belongs to the amino acid/polyamine transporter 2 family.	NA	PE2	2
+NX_Q08AI8	Protein mab-21-like 4	447	49565	6.02	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	NA	NA	PE1	2
+NX_Q08AM6	Protein VAC14 homolog	782	87973	5.76	0	Microsome membrane;Cytoplasmic vesicle;Cytosol;Endosome membrane	Striatonigral degeneration, childhood-onset	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.	NA	Belongs to the VAC14 family.	HTLV-I infection;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane	PE1	16
+NX_Q08AN1	Zinc finger protein 616	781	90273	9.66	0	Centrosome;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q08E93	Protein FAM27E3	113	13507	11.89	0	NA	NA	NA	NA	Belongs to the FAM27 family.	NA	PE1	9
+NX_Q08ER8	Zinc finger protein 543	600	68404	8.18	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q08ET2	Sialic acid-binding Ig-like lectin 14	396	43970	8.24	1	Cell membrane	NA	Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.	NA	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	DAP12 interactions;Neutrophil degranulation	PE1	19
+NX_Q08J23	RNA cytosine C(5)-methyltransferase NSUN2	767	86471	6.33	0	Extracellular exosome;Cytoplasm;Mitochondrion;Nucleolus;Nucleoplasm;Spindle	Mental retardation, autosomal recessive 5	RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31358969, PubMed:31199786). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). TRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847).	Phosphorylated at Ser-139 by AURKB during mitosis, leading to abolish methyltransferase activity and the interaction with NPM1.	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.	tRNA modification in the nucleus and cytosol	PE1	5
+NX_Q09013	Myotonin-protein kinase	629	69385	4.92	1	Mitochondrion outer membrane;Nucleus outer membrane;Endoplasmic reticulum membrane;Cell membrane;Mitochondrion membrane;Cytoplasmic vesicle;Cytosol;Sarcoplasmic reticulum membrane	Dystrophia myotonica 1	Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.	Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK.;Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity.;DMPK is phosphorylated by RAF1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.	Ion homeostasis	PE1	19
+NX_Q09019	Dystrophia myotonica WD repeat-containing protein	674	70438	6.9	0	Cell membrane;Perikaryon;Dendrite;Nucleus;Cytoskeleton	NA	NA	NA	NA	NA	PE1	19
+NX_Q09028	Histone-binding protein RBBP4	425	47656	4.74	0	Nucleus	NA	Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.	NA	Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.	PKMTs methylate histone lysines;RNA Polymerase I Transcription Initiation;Oxidative Stress Induced Senescence;PRC2 methylates histones and DNA;HDACs deacetylate histones;Deposition of new CENPA-containing nucleosomes at the centromere;G0 and Early G1;G1/S-Specific Transcription;Polo-like kinase mediated events;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry;Activation of anterior HOX genes in hindbrain development during early embryogenesis;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;Transcriptional Regulation by E2F6;Regulation of PTEN gene transcription	PE1	1
+NX_Q09161	Nuclear cap-binding protein subunit 1	790	91839	5.99	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (PubMed:26382858).	NA	Belongs to the NCBP1 family.	RNA transport;mRNA surveillance pathway;Spliceosome;snRNP Assembly;SLBP independent Processing of Histone Pre-mRNAs;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing;Processing of Capped Intron-Containing Pre-mRNA;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;Processing of Intronless Pre-mRNAs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;Signaling by FGFR2 IIIa TM;Regulation of expression of SLITs and ROBOs;RNA Polymerase II Transcription Termination	PE1	9
+NX_Q09327	Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	533	61313	8.54	1	Golgi apparatus membrane	NA	It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate (PubMed:19403558). Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location (PubMed:19403558). Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation (PubMed:26801611). In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage (By similarity).	NA	Belongs to the glycosyltransferase 17 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Reactions specific to the hybrid N-glycan synthesis pathway	PE1	22
+NX_Q09328	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A	741	84543	8.41	1	Secreted;Golgi apparatus membrane	NA	Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A: Promotes proliferation of umbilical vein endothelial cells and angiogenesis, at least in part by promoting the release of the growth factor FGF2 from the extracellular matrix.;Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2 (PubMed:10395745, PubMed:22614033, PubMed:30140003). Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling. Required for efficient interaction between TGFB1 and its receptor. Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF. MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways. Promotes cell migration. Contributes to the regulation of the inflammatory response. MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens. Required for normal leukocyte evasation and accumulation at sites of inflammation (By similarity). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis (PubMed:22614033).	A secreted form is released from the membrane after cleavage by gamma-secretase.;N-glycosylated.	Belongs to the glycosyltransferase 18 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;N-Glycan antennae elongation	PE1	2
+NX_Q09428	ATP-binding cassette sub-family C member 8	1581	176992	7.99	17	Golgi apparatus;Cytosol;Nucleolus;Cell membrane	Transient neonatal diabetes mellitus 2;Leucine-induced hypoglycemia;Diabetes mellitus, permanent neonatal;Familial hyperinsulinemic hypoglycemia 1	Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.	NA	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.	ABC transporters;Type II diabetes mellitus;Regulation of insulin secretion;ATP sensitive Potassium channels;Defective ABCC8 can cause hypoglycemias and hyperglycemias	PE1	11
+NX_Q09470	Potassium voltage-gated channel subfamily A member 1	495	56466	5.08	6	Presynaptic cell membrane;Cell membrane;Cell junction;Perikaryon;Membrane;Endoplasmic reticulum;Presynapse;Synapse;Cytoplasmic vesicle;Axon;Dendrite	Myokymia isolated 1;Episodic ataxia 1	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:12077175, PubMed:17156368). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:19968958, PubMed:19307729, PubMed:19903818). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses (PubMed:11026449, PubMed:17136396). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:23903368, PubMed:19307729).	N-glycosylated.;Palmitoylated on Cys-243; which may be required for membrane targeting.;Phosphorylated on tyrosine residues. Phosphorylation increases in response to NRG1; this inhibits channel activity (By similarity). Phosphorylation at Ser-446 regulates channel activity by down-regulating expression at the cell membrane (PubMed:23774215).	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.	Voltage gated Potassium channels	PE1	12
+NX_Q09472	Histone acetyltransferase p300	2414	264161	8.81	0	Cytoplasm;Nucleoplasm;Nucleus;Chromosome	Menke-Hennekam syndrome 2;Rubinstein-Taybi syndrome 2	(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein.;Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degragation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA) or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation or propionylation, respectively (PubMed:25818647, PubMed:17267393). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (E)-but-2-enoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950).	Citrullinated at Arg-2142 by PADI4, which impairs methylation by CARM1 and promotes interaction with NCOA2/GRIP1.;Methylated at Arg-580 and Arg-604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates apoptotic response. Also methylated at Arg-2142 by CARM1, which impairs interaction with NCOA2/GRIP1.;Acetylated on Lys at up to 17 positions by intermolecular autocatalysis. Deacetylated in the transcriptional repression domain (CRD1) by SIRT1, preferentially at Lys-1020. Deacetylated by SIRT2, preferentially at Lys-418, Lys-423, Lys-1542, Lys-1546, Lys-1549, Lys-1699, Lys-1704 and Lys-1707.;Sumoylated; sumoylation in the transcriptional repression domain (CRD1) mediates transcriptional repression. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3.;Phosphorylated by HIPK2 in a RUNX1-dependent manner. This phosphorylation that activates EP300 happens when RUNX1 is associated with DNA and CBFB. Phosphorylated by ROCK2 and this enhances its activity. Phosphorylation at Ser-89 by AMPK reduces interaction with nuclear receptors, such as PPARG.;Probable target of ubiquitination by FBXO3, leading to rapid proteasome-dependent degradation.;EP300 is phosphorylated by HIPK2;EP300 is phosphorylated by ROCK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Cell cycle;Wnt signaling pathway;Notch signaling pathway;TGF-beta signaling pathway;Adherens junction;Jak-STAT signaling pathway;Long-term potentiation;Melanogenesis;Huntington's disease;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Pathways in cancer;Renal cell carcinoma;Prostate cancer;HATs acetylate histones;PPARA activates gene expression;Formation of the beta-catenin:TCF transactivating complex;TRAF6 mediated IRF7 activation;Pre-NOTCH Transcription and Translation;Regulation of gene expression by Hypoxia-inducible Factor;RORA activates gene expression;Circadian Clock;Polo-like kinase mediated events;Attenuation phase;NOTCH2 intracellular domain regulates transcription;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Transcriptional regulation of white adipocyte differentiation;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;TRAF3-dependent IRF activation pathway;CD209 (DC-SIGN) signaling;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;Regulation of TP53 Activity through Acetylation;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Regulation of TP53 Activity through Methylation;Metalloprotease DUBs;Activation of the TFAP2 (AP-2) family of transcription factors;PI5P Regulates TP53 Acetylation;Regulation of RUNX3 expression and activity;RUNX3 regulates NOTCH signaling;RUNX3 regulates p14-ARF;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;NOTCH3 Intracellular Domain Regulates Transcription;Estrogen-dependent gene expression;SUMOylation of transcription cofactors;NOTCH4 Intracellular Domain Regulates Transcription;FOXO-mediated transcription of cell death genes;Regulation of FOXO transcriptional activity by acetylation;Transcriptional regulation of granulopoiesis	PE1	22
+NX_Q09666	Neuroblast differentiation-associated protein AHNAK	5890	629101	5.8	0	Cytosol;Nucleus;Cell membrane	NA	May be required for neuronal cell differentiation.	NA	NA	NA	PE1	11
+NX_Q09FC8	Zinc finger protein 415	603	68798	9.16	0	Cytoplasm;Nucleus;Nucleolus;Cytoskeleton	NA	Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53.	NA	NA	Generic Transcription Pathway	PE1	19
+NX_Q09MP3	RAD51-associated protein 2	1159	133907	7.11	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q0D2H9	Putative golgin subfamily A member 8D	430	48423	5.41	0	NA	NA	NA	NA	Belongs to the GOLGA8 family.	NA	PE5	15
+NX_Q0D2I5	Intermediate filament family orphan 1	559	61979	4.83	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	NA	PE1	12
+NX_Q0D2J5	Zinc finger protein 763	394	46099	9.32	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE2	19
+NX_Q0D2K0	Magnesium transporter NIPA4	466	50058	7.09	9	Membrane	Ichthyosis, congenital, autosomal recessive 6	Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway.	NA	Belongs to the NIPA family.	Miscellaneous transport and binding events	PE1	5
+NX_Q0D2K2	Kelch-like protein 30	578	63976	5.59	0	Centriolar satellite	NA	NA	NA	NA	NA	PE1	2
+NX_Q0D2K3	Protein ripply1	151	16379	4.32	0	Nucleus	NA	Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity).	NA	Belongs to the ripply family.	NA	PE1	X
+NX_Q0D2K5	Putative EGF-like and EMI domain-containing protein 1	195	21632	8.36	0	NA	NA	NA	NA	NA	NA	PE5	3
+NX_Q0GE19	Sodium/bile acid cotransporter 7	340	37432	9.68	10	Endoplasmic reticulum membrane;Cell membrane;Golgi apparatus membrane	Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis	Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization (PubMed:30082715, PubMed:29878199). Also involved in the regulation of cellular calcium homeostasis (PubMed:30082715, PubMed:31191616). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).	NA	Belongs to the unknown BART superfamily-1 (UBS1) (TC 2.A.93) family.	NA	PE1	4
+NX_Q0IIM8	TBC1 domain family member 8B	1120	128709	5.66	0	Cytosol	Nephrotic syndrome 20	Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein.	NA	NA	Golgi Associated Vesicle Biogenesis	PE1	X
+NX_Q0IIN9	Putative uncharacterized protein ZNF252P-AS1	211	22478	8.78	0	NA	NA	NA	NA	NA	NA	PE5	8
+NX_Q0JRZ9	F-BAR domain only protein 2	810	88924	6.42	0	Cytoplasmic vesicle;Cytosol;Centrosome;Clathrin-coated pit	NA	Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.	Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination (By similarity).	Belongs to the FCHO family.	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	5
+NX_Q0P140	Putative uncharacterized protein HSD52	79	8416	4.93	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q0P5N6	ADP-ribosylation factor-like protein 16	197	20936	8.57	0	NA	NA	NA	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	17
+NX_Q0P5P2	Uncharacterized protein C17orf67	90	10670	8.74	0	Secreted	NA	NA	NA	NA	NA	PE1	17
+NX_Q0P641	Uncharacterized protein C2orf80	193	22038	9.47	0	Golgi apparatus	NA	NA	NA	NA	NA	PE2	2
+NX_Q0P651	Protein ABHD18	414	46954	9.37	0	Secreted;Nucleus membrane	NA	NA	NA	Belongs to the AB hydrolase superfamily.	NA	PE1	4
+NX_Q0P670	Uncharacterized protein SPEM2	501	57131	9.69	1	Membrane	NA	NA	NA	NA	NA	PE1	17
+NX_Q0P6D2	Divergent protein kinase domain 1C	419	46420	6.38	1	Endoplasmic reticulum membrane	NA	NA	Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.	Belongs to the DIPK family.	NA	PE1	18
+NX_Q0P6D6	Coiled-coil domain-containing protein 15	951	110484	6.05	0	Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	11
+NX_Q0P6H9	Transmembrane protein 62	643	73133	9.34	6	Nucleolus;Membrane;Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	15
+NX_Q0PNE2	Elongator complex protein 6	266	29793	6.36	0	Nucleoplasm;Cytosol;Centrosome	NA	Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:22854966). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity).	NA	Belongs to the ELP6 family.	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.;HATs acetylate histones	PE1	3
+NX_Q0VAA2	Leucine-rich repeat-containing protein 74A	488	54535	5.22	0	NA	NA	NA	NA	NA	NA	PE1	14
+NX_Q0VAA5	PI-PLC X domain-containing protein 2	305	34777	9.51	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE2	3
+NX_Q0VAF6	Syncollin	134	14405	8.11	0	Secretory vesicle membrane	NA	Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity).	Contains intrachain disulfide bonds.	NA	NA	PE1	19
+NX_Q0VAK6	Leiomodin-3	560	64914	5.42	0	Cytoplasm;A band;M line;Cytoskeleton	Nemaline myopathy 10	Essential for the organization of sarcomeric actin thin filaments in skeletal muscle (PubMed:25250574). Increases the rate of actin polymerization (PubMed:25250574).	Ubiquitinated, leading to its degradation. Interaction with KLHL40 negatively regulates ubiquitination and degradation.	Belongs to the tropomodulin family.	NA	PE1	3
+NX_Q0VAM2	Ras-GEF domain-containing family member 1B	473	55359	8.19	0	Early endosome;Nucleoplasm;Late endosome;Cytoplasmic vesicle;Midbody	NA	Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).	NA	NA	NA	PE1	4
+NX_Q0VAQ4	Small cell adhesion glycoprotein	97	10679	4.21	1	Cytoplasmic vesicle membrane;Nucleoplasm;Cell membrane	NA	May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.	O-glycosylated. The O-glycan is modified with sialic acid residues.	Belongs to the SMAGP family.	NA	PE1	12
+NX_Q0VD83	Apolipoprotein B receptor	1097	115634	4.38	0	Cell membrane	NA	Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.	There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R).	NA	VLDL clearance	PE1	16
+NX_Q0VD86	Protein INCA1	236	26817	6.92	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity).	Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues.	Belongs to the INCA family.	NA	PE1	17
+NX_Q0VDD5	Putative uncharacterized protein encoded by MIR22HG	57	6478	11.21	0	NA	NA	NA	NA	NA	NA	PE5	17
+NX_Q0VDD7	Uncharacterized protein C19orf57	668	69556	4.71	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q0VDD8	Dynein heavy chain 14, axonemal	3507	399895	6.52	0	Centrosome;Cilium axoneme	NA	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).	NA	Belongs to the dynein heavy chain family.	NA	PE1	1
+NX_Q0VDE8	Adipogenin	80	9465	4.68	1	Membrane;Nucleus	NA	Plays a role in stimulating adipocyte differentiation and development.	NA	Belongs to the adipogenin family.	NA	PE2	20
+NX_Q0VDF9	Heat shock 70 kDa protein 14	509	54794	5.41	0	Cytosol	NA	Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.	NA	Belongs to the heat shock protein 70 family.	Regulation of HSF1-mediated heat shock response	PE1	10
+NX_Q0VDG4	Secernin-3	424	48544	5.38	0	Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the peptidase C69 family. Secernin subfamily.	NA	PE1	2
+NX_Q0VDI3	Transmembrane protein 267	215	24217	8.91	3	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	5
+NX_Q0VF49	Uncharacterized protein KIAA2012	1180	135305	8.53	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q0VF96	Cingulin-like protein 1	1302	149079	5.51	0	Tight junction;Cell junction;Nucleus	Aromatase excess syndrome	May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons.	NA	Belongs to the cingulin family.	NA	PE1	15
+NX_Q0VFX4	Putative uncharacterized protein LOC100128554	171	18056	8.78	0	NA	NA	NA	NA	NA	NA	PE2	12
+NX_Q0VFZ6	Coiled-coil domain-containing protein 173	552	66403	8.92	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q0VG06	Fanconi anemia core complex-associated protein 100	881	93433	5.12	0	Nucleoplasm;Nucleus	NA	Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed.	NA	NA	Fanconi anemia pathway;Fanconi Anemia Pathway	PE1	17
+NX_Q0VG73	Putative uncharacterized protein LOC152225	95	10763	6.38	0	NA	NA	NA	NA	NA	NA	PE5	3
+NX_Q0VG99	Mesoderm posterior protein 2	397	41760	7.05	0	Nucleus	Spondylocostal dysostosis 2, autosomal recessive	Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.	Degraded by the proteasome.	NA	NA	PE1	15
+NX_Q0VGE8	Zinc finger protein 816	651	75725	9.44	0	Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q0VGL1	Ragulator complex protein LAMTOR4	99	10741	6.07	0	Cytoplasmic vesicle;Lysosome	NA	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.	NA	Belongs to the LAMTOR4 family.	Macroautophagy;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;mTOR signalling;mTORC1-mediated signalling;Regulation of PTEN gene transcription	PE1	7
+NX_Q0WX57	Ubiquitin carboxyl-terminal hydrolase 17-like protein 24	530	59711	8.35	0	Endoplasmic reticulum;Nucleolus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE1	4
+NX_Q0Z7S8	Fatty acid-binding protein 9	132	15093	7.79	0	Cytoplasm	NA	NA	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Triglyceride catabolism	PE1	8
+NX_Q0ZGT2	Nexilin	675	80658	5.31	0	Cytoplasm;Cell membrane;Adherens junction;Z line;Cytoskeleton	Cardiomyopathy, familial hypertrophic 20;Cardiomyopathy, dilated 1CC	Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.	NA	NA	NA	PE1	1
+NX_Q0ZLH3	Pejvakin	352	39913	9.18	0	Mitochondrion	Deafness, autosomal recessive, 59	Essential in the activity of auditory pathway neurons.	NA	Belongs to the gasdermin family.	NA	PE1	2
+NX_Q10469	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	447	51550	8.99	1	Golgi apparatus;Golgi apparatus membrane	Congenital disorder of glycosylation 2A	Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans.	NA	Belongs to the glycosyltransferase 16 (GT16) protein family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Reactions specific to the complex N-glycan synthesis pathway;Defective MGAT2 causes MGAT2-CDG (CDG-2a)	PE1	14
+NX_Q10471	Polypeptide N-acetylgalactosaminyltransferase 2	571	64733	8.63	1	Golgi stack membrane;Golgi apparatus;Secreted	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins;COPI-independent Golgi-to-ER retrograde traffic	PE1	1
+NX_Q10472	Polypeptide N-acetylgalactosaminyltransferase 1	559	64219	7.83	1	Golgi stack membrane;Secreted	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins;COPI-independent Golgi-to-ER retrograde traffic	PE1	18
+NX_Q10567	AP-1 complex subunit beta-1	949	104637	4.94	0	Golgi apparatus;Cytoplasmic vesicle;Cytosol;Clathrin-coated vesicle membrane	NA	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP1B1 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the adaptor complexes large subunit family.	Lysosome;MHC class II antigen presentation;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Nef mediated downregulation of MHC class I complex cell surface expression	PE1	22
+NX_Q10570	Cleavage and polyadenylation specificity factor subunit 1	1443	160884	5.99	0	Nucleoplasm	NA	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.	The N-terminus is blocked.	Belongs to the CPSF1 family.	mRNA surveillance pathway;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;tRNA processing in the nucleus;RNA Polymerase II Transcription Termination	PE1	8
+NX_Q10571	Transcriptional activator MN1	1320	136001	6.22	0	Nucleoplasm	NA	Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable).	NA	NA	NA	PE1	22
+NX_Q10586	D site-binding protein	325	34349	9.34	0	Nucleus	NA	This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.	NA	Belongs to the bZIP family. PAR subfamily.	BMAL1:CLOCK,NPAS2 activates circadian gene expression	PE1	19
+NX_Q10587	Thyrotroph embryonic factor	303	33248	5.81	0	Nucleus	NA	Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.	NA	Belongs to the bZIP family. PAR subfamily.	NA	PE1	22
+NX_Q10588	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	318	35724	7.97	0	Cell membrane	NA	Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.	NA	Belongs to the ADP-ribosyl cyclase family.	Nicotinate and nicotinamide metabolism;Metabolic pathways;Calcium signaling pathway;Salivary secretion;Pancreatic secretion;Nicotinate metabolism;Neutrophil degranulation;Post-translational modification: synthesis of GPI-anchored proteins	PE1	4
+NX_Q10589	Bone marrow stromal antigen 2	180	19769	5.43	1	trans-Golgi network;Golgi apparatus;Cytoplasm;Cell membrane;Apical cell membrane;Late endosome;Cytosol;Membrane raft	NA	Are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439).;IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.;Acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed:23028328).;Is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439).	The GPI anchor is essential for its antiviral activity.;Monoubiquitinated by KSHV E3 ubiquitin-protein ligase K5, leading to its targeting to late endosomes and degradation.	Belongs to the tetherin family.	Interferon alpha/beta signaling;Neutrophil degranulation	PE1	19
+NX_Q10713	Mitochondrial-processing peptidase subunit alpha	525	58253	6.45	0	Mitochondrion matrix;Mitochondrion inner membrane;Mitochondrion	Spinocerebellar ataxia, autosomal recessive, 2	Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which is required for maturation of the majority of mitochondrial precursor proteins (PubMed:25808372). Most MPP cleavage sites follow an arginine at position -2 (By similarity).	NA	Belongs to the peptidase M16 family.	Mitochondrial protein import;Processing of SMDT1	PE1	9
+NX_Q107X0	Putative protein KRIP1	134	14401	9.73	0	Cytoplasm;Nucleus	NA	NA	NA	NA	NA	PE5	19
+NX_Q10981	Galactoside 2-alpha-L-fucosyltransferase 2	343	39017	8.69	1	Golgi stack membrane;Cytosol;Cell membrane	NA	Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).	NA	Belongs to the glycosyltransferase 11 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Glycosphingolipid biosynthesis - globo series;Metabolic pathways;Lewis blood group biosynthesis;ABO blood group biosynthesis	PE1	19
+NX_Q11128	Alpha-(1,3)-fucosyltransferase 5	374	43008	8.54	1	Golgi stack membrane	NA	May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.	NA	Belongs to the glycosyltransferase 10 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Lewis blood group biosynthesis	PE2	19
+NX_Q11130	Alpha-(1,3)-fucosyltransferase 7	342	39239	10.07	1	Golgi stack membrane;Golgi apparatus	NA	Catalyzes alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.	NA	Belongs to the glycosyltransferase 10 family.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Lewis blood group biosynthesis	PE1	9
+NX_Q11201	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	340	39075	9.21	1	Golgi stack membrane;Secreted	NA	Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.	The soluble form derives from the membrane form by proteolytic processing.	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Glycosaminoglycan biosynthesis - keratan sulfate;Glycosphingolipid biosynthesis - globo series;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Sialic acid metabolism;Termination of O-glycan biosynthesis;Keratan sulfate biosynthesis	PE1	8
+NX_Q11203	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase	375	42171	9.1	1	Golgi stack membrane;Secreted	Epileptic encephalopathy, early infantile, 15;Mental retardation, autosomal recessive 12	Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc.	The soluble form derives from the membrane form by proteolytic processing.	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;Glycosaminoglycan biosynthesis - keratan sulfate;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Sialic acid metabolism;Termination of O-glycan biosynthesis;Keratan sulfate biosynthesis;Pre-NOTCH Processing in Golgi;Defective ST3GAL3 causes MCT12 and EIEE15;Lewis blood group biosynthesis	PE1	1
+NX_Q11206	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4	333	38045	9.45	1	Golgi stack membrane;Secreted	NA	Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant.	The soluble form derives from the membrane form by proteolytic processing.	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Sialic acid metabolism;Termination of O-glycan biosynthesis;Keratan sulfate biosynthesis;Pre-NOTCH Processing in Golgi;N-Glycan antennae elongation;Lewis blood group biosynthesis	PE1	11
+NX_Q12756	Kinesin-like protein KIF1A	1690	191064	5.86	0	Cytosol;Neuron projection;Centriolar satellite;Cytoskeleton	Mental retardation, autosomal dominant 9;Spastic paraplegia 30, autosomal recessive;Neuropathy, hereditary sensory, 2C	Motor for anterograde axonal transport of synaptic vesicle precursors.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	2
+NX_Q12765	Secernin-1	414	46382	4.66	0	Cytoplasm;Cytosol	NA	Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).	NA	Belongs to the peptidase C69 family. Secernin subfamily.	NA	PE1	7
+NX_Q12766	HMG domain-containing protein 3	1538	168334	8.39	0	Nucleus;Nucleolus	NA	NA	NA	NA	NA	PE1	5
+NX_Q12767	Transmembrane protein 94	1356	151151	5.99	10	Membrane	Intellectual developmental disorder with cardiac defects and dysmorphic facies	NA	NA	NA	NA	PE1	17
+NX_Q12768	WASH complex subunit 5	1159	134286	6.54	0	Nucleoplasm;Endoplasmic reticulum;Early endosome;Cytosol	Ritscher-Schinzel syndrome 1;Spastic paraplegia 8, autosomal dominant	Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666).	NA	Belongs to the strumpellin family.	NA	PE1	8
+NX_Q12769	Nuclear pore complex protein Nup160	1436	162121	5.31	0	Nuclear pore complex	Nephrotic syndrome 19	Involved in poly(A)+ RNA transport.	NA	NA	RNA transport;Separation of Sister Chromatids;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	11
+NX_Q12770	Sterol regulatory element-binding protein cleavage-activating protein	1279	139729	6.41	8	COPII-coated vesicle membrane;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).	Ubiquitinated at Lys-454 and Lys-466. RNF145 triggers ubiquitination of SCAP, likely inhibiting SCAP:SREBPF2 complex transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2.	Belongs to the WD repeat SCAP family.	Regulation of cholesterol biosynthesis by SREBP (SREBF)	PE1	3
+NX_Q12772	Sterol regulatory element-binding protein 2	1141	123688	8.72	2	Endoplasmic reticulum membrane;Endoplasmic reticulum;Nucleoplasm;COPII-coated vesicle membrane;Golgi apparatus membrane;Cytoplasmic vesicle;Nucleus	NA	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.	At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.;Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression.	Belongs to the SREBP family.	PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of cholesterol biosynthesis by SREBP (SREBF)	PE1	22
+NX_Q12774	Rho guanine nucleotide exchange factor 5	1597	176799	5.37	0	Cytoplasm;Cell membrane;Podosome;Nucleoplasm;Cytosol;Nucleus	NA	Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity).	Activation of SRC induces tyrosine phosphorylation of ARHGEF5.	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	7
+NX_Q12778	Forkhead box protein O1	655	69662	6.28	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Rhabdomyosarcoma 2	Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity).	Methylation inhibits AKT1-mediated phosphorylation at Ser-256 and is increased by oxidative stress.;Once in the nucleus, acetylated by CREBBP/EP300. Acetylation diminishes the interaction with target DNA and attenuates the transcriptional activity. It increases the phosphorylation at Ser-256. Deacetylation by SIRT1 results in reactivation of the transcriptional activity. Oxidative stress by hydrogen peroxide treatment appears to promote deacetylation and uncoupling of insulin-induced phosphorylation. By contrast, resveratrol acts independently of acetylation.;Acetylated. Acetylation at Lys-262, Lys-265 and Lys-274 are necessary for autophagic cell death induction. Deacetylated by SIRT2 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagic cell death.;Ubiquitinated by SKP2. Ubiquitination leads to proteasomal degradation.;Phosphorylation by NLK promotes nuclear export and inhibits the transcriptional activity. In response to growth factors, phosphorylation on Thr-24, Ser-256 and Ser-322 by PKB/AKT1 promotes nuclear export and inactivation of transactivational activity. Phosphorylation on Thr-24 is required for binding 14-3-3 proteins. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24 and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CDK1, leading to nuclear exclusion and loss of function. Stress signals, such as response to oxygen or nitric oxide, attenuate the PKB/AKT1-mediated phosphorylation leading to nuclear retention. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Dephosphorylated on Thr-24 and Ser-256 by PP2A in beta-cells under oxidative stress leading to nuclear retention (By similarity). Phosphorylation of Ser-249 by CDK1 disrupts binding of 14-3-3 proteins leading to nuclear accumulation and has no effect on DNA-binding nor transcriptional activity. Phosphorylation by STK4/MST1 on Ser-212, upon oxidative stress, inhibits binding to 14-3-3 proteins and nuclear export.;FOXO1 is phosphorylated by PAK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);FOXO1 is phosphorylated by NLK (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254);FOXO1 is phosphorylated by ROCK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Insulin signaling pathway;Pathways in cancer;Prostate cancer;MAPK6/MAPK4 signaling;Regulation of gene expression in beta cells;AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;AKT-mediated inactivation of FOXO1A;Interleukin-4 and Interleukin-13 signaling;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell death genes;Regulation of localization of FOXO transcription factors;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes	PE1	13
+NX_Q12788	Transducin beta-like protein 3	808	89035	6.44	0	Nucleolus	NA	NA	NA	NA	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	16
+NX_Q12789	General transcription factor 3C polypeptide 1	2109	238875	7.01	0	Nucleoplasm;Nucleolus;Nucleus	NA	Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.	NA	Belongs to the TFIIIC subunit 1 family.	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter	PE1	16
+NX_Q12791	Calcium-activated potassium channel subunit alpha-1	1236	137560	6.66	7	Cell membrane	Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy	Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).	Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity.;Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network.	Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.	Vascular smooth muscle contraction;Salivary secretion;Pancreatic secretion;Ca2+ activated K+ channels;cGMP effects	PE1	10
+NX_Q12792	Twinfilin-1	350	40283	6.48	0	Cytoplasm;Cytosol;Cytoskeleton	NA	Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).	Phosphorylated on serine and threonine residues.	Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.	NA	PE1	12
+NX_Q12794	Hyaluronidase-1	435	48368	6.31	0	Secreted;Lysosome	Mucopolysaccharidosis 9	May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.	NA	Belongs to the glycosyl hydrolase 56 family.	Glycosaminoglycan degradation;Metabolic pathways;Lysosome;Hyaluronan uptake and degradation;CS/DS degradation;MPS IX - Natowicz syndrome	PE1	3
+NX_Q12796	Proline-rich nuclear receptor coactivator 1	327	35225	10.51	0	Nucleoplasm;Nucleolus;Nucleus	NA	Nuclear receptor coactivator. May play a role in signal transduction.	NA	Belongs to the PNRC family. PNRC1 subfamily.	NA	PE1	6
+NX_Q12797	Aspartyl/asparaginyl beta-hydroxylase	758	85863	4.92	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Sarcoplasmic reticulum membrane	Facial dysmorphism, lens dislocation, anterior segment abnormalities, and spontaneous filtering blebs	Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions.;Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.;Regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells.	NA	Belongs to the aspartyl/asparaginyl beta-hydroxylase family.	Stimuli-sensing channels;Ion homeostasis	PE1	8
+NX_Q12798	Centrin-1	172	19570	4.79	0	Centrosome	NA	Plays a fundamental role in microtubule-organizing center structure and function (PubMed:8175926). Plays a role in sperm cilia formation (By similarity).	NA	Belongs to the centrin family.	NA	PE1	18
+NX_Q12799	T-complex protein 10A homolog	353	38267	8.46	0	NA	NA	NA	NA	Belongs to the TCP10 family.	NA	PE1	6
+NX_Q12800	Alpha-globin transcription factor CP2	502	57256	5.53	0	Nucleoplasm;Cytosol;Nucleus	NA	Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.	NA	Belongs to the grh/CP2 family. CP2 subfamily.	NA	PE1	12
+NX_Q12802	A-kinase anchor protein 13	2813	307550	5.12	0	Cytoplasm;Cell cortex;Membrane;Cytosol;Nucleus	NA	Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity).	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	15
+NX_Q12805	EGF-containing fibulin-like extracellular matrix protein 1	493	54641	4.95	0	Extracellular matrix;Mitochondrion;Extracellular space	Doyne honeycomb retinal dystrophy	Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.	NA	Belongs to the fibulin family.	Molecules associated with elastic fibres	PE1	2
+NX_Q12809	Potassium voltage-gated channel subfamily H member 2	1159	126655	8.2	6	Cell membrane	Short QT syndrome 1;Long QT syndrome 2	Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.;Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.;Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661).	Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.	Voltage gated Potassium channels;Phase 3 - rapid repolarisation	PE1	7
+NX_Q12815	Tastin	778	83857	7.2	0	Cytoplasm	NA	Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.	NA	NA	NA	PE1	12
+NX_Q12816	Trophinin	1431	143716	9.18	0	Nucleoplasm;Nucleolus	NA	Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.	NA	NA	NA	PE1	X
+NX_Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	385	44141	5.86	0	Nucleoplasm;Nucleus;Nucleolus	Coffin-Siris syndrome 3;Rhabdoid tumor predisposition syndrome 1;Schwannomatosis 1	Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.	NA	Belongs to the SNF5 family.	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	22
+NX_Q12829	Ras-related protein Rab-40B	278	30956	9.68	0	Cell membrane	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the small GTPase superfamily. Rab family.	Protein modification; protein ubiquitination.;RAB geranylgeranylation	PE1	17
+NX_Q12830	Nucleosome-remodeling factor subunit BPTF	3046	338262	6.15	0	Cytoplasm;Nucleus	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.	Phosphorylation enhances DNA-binding.;Highly susceptible to proteolysis.	Belongs to the PBTF family.	NA	PE1	17
+NX_Q12834	Cell division cycle protein 20 homolog	499	54723	9.33	0	Nucleoplasm;Spindle pole;Centrosome;Cytosol	NA	Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.	Phosphorylated during mitosis, probably by maturation promoting factor (MPF). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161. Phosphorylated by NEK2.;Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex.;Dephosphorylated by CTDP1.;Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).;CDC20 is phosphorylated by NEK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the WD repeat CDC20/Fizzy family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;HTLV-I infection;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;Antigen processing: Ubiquitination &amp; Proteasome degradation;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;APC-Cdc20 mediated degradation of Nek2A;Phosphorylation of Emi1;Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Ub-specific processing proteases	PE1	1
+NX_Q12836	Zona pellucida sperm-binding protein 4	540	59400	6.23	1	Extracellular matrix;Cell membrane	NA	Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.	Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.	Belongs to the ZP domain family. ZPB subfamily.	Interaction With Cumulus Cells And The Zona Pellucida	PE1	1
+NX_Q12837	POU domain, class 4, transcription factor 2	409	43087	9.33	0	Cytoplasm;Nucleus speckle;Nucleus	NA	Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:19266028, PubMed:23805044). Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity).	NA	Belongs to the POU transcription factor family. Class-4 subfamily.	Regulation of TP53 Activity through Association with Co-factors	PE1	4
+NX_Q12840	Kinesin heavy chain isoform 5A	1032	117378	5.65	0	Perikaryon;Nucleoplasm;Cytosol;Spindle;Perinuclear region;Cytoskeleton	Amyotrophic lateral sclerosis 25;Spastic paraplegia 10, autosomal dominant;Myoclonus, intractable, neonatal	Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.	Dopaminergic synapse;MHC class II antigen presentation;Insulin processing;Kinesins;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic	PE1	12
+NX_Q12841	Follistatin-related protein 1	308	34986	5.39	0	Cytoplasmic vesicle;Cytosol;Secreted	NA	May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).	NA	NA	Signaling by BMP;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	3
+NX_Q12846	Syntaxin-4	297	34180	5.92	1	Cell membrane	NA	Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.	STX4 is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);STX4 is phosphorylated by PRKCG (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);STX4 is phosphorylated by PRKCE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);STX4 is phosphorylated by PRKCB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;Vasopressin-regulated water reabsorption;ER-Phagosome pathway;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Disinhibition of SNARE formation;Other interleukin signaling;trans-Golgi Network Vesicle Budding	PE1	16
+NX_Q12849	G-rich sequence factor 1	480	53126	5.83	0	Cytoplasm;Mitochondrion matrix;Mitochondrion	NA	Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381).	NA	NA	Viral mRNA Translation	PE1	4
+NX_Q12851	Mitogen-activated protein kinase kinase kinase kinase 2	820	91556	5.91	0	Cytoplasmic vesicle;Cytoplasm;Golgi apparatus membrane;Basolateral cell membrane	NA	Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. Regulation of vesicle targeting or fusion.	Polyubiquitinated through 'Lys-48'-polyubiquitin chains, allowing proteasomal turnover. Ubiquitination requires the kinase activity of MAP4K2/GCK.;Autophosphorylated in response to tumor necrosis factor (TNF), endotoxins or proinflammatory stimuli. Autophosphorylation leads to activation.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	MAPK signaling pathway	PE1	11
+NX_Q12852	Mitogen-activated protein kinase kinase kinase 12	859	93219	6.03	0	Nucleoplasm;Cytoplasm;Cell junction;Cell membrane	NA	Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway.	Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated (By similarity).;The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway	PE1	12
+NX_Q12857	Nuclear factor 1 A-type	509	55944	8.66	0	Nucleoplasm;Nucleus	Brain malformations with or without urinary tract defects	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	NA	Belongs to the CTF/NF-I family.	RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation	PE1	1
+NX_Q12860	Contactin-1	1018	113320	5.62	0	Cell membrane	Myopathy, congenital, Compton-North	Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).	NA	Belongs to the immunoglobulin superfamily. Contactin family.	Cell adhesion molecules (CAMs);L1CAM interactions;Activated NOTCH1 Transmits Signal to the Nucleus;NOTCH2 Activation and Transmission of Signal to the Nucleus;Neurofascin interactions	PE1	12
+NX_Q12864	Cadherin-17	832	92219	4.99	1	Nucleoplasm;Cell junction;Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.	NA	NA	Adherens junctions interactions	PE1	8
+NX_Q12866	Tyrosine-protein kinase Mer	999	110249	5.51	1	Cell membrane;Membrane;Endoplasmic reticulum;Cytosol;Midbody	Retinitis pigmentosa 38	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.	Autophosphorylated on Tyr-749, Tyr-753 and Tyr-754 in the activation loop allowing full activity. Autophosphorylated on Tyr-872 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 (By similarity).	Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.	Cell surface interactions at the vascular wall	PE1	2
+NX_Q12870	Transcription factor 15	199	20816	9.97	0	Nucleus speckle;Nucleus	NA	May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.	NA	NA	NA	PE2	20
+NX_Q12872	Splicing factor, suppressor of white-apricot homolog	951	104822	8.11	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10.	NA	NA	NA	PE1	12
+NX_Q12873	Chromodomain-helicase-DNA-binding protein 3	2000	226592	6.92	0	Centriolar satellite;Nucleolus;Nucleoplasm;Centrosome;Nucleus	Snijders Blok-Campeau syndrome	Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.	NA	Belongs to the SNF2/RAD54 helicase family.	RNA Polymerase I Transcription Initiation;HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;SUMOylation of chromatin organization proteins;Regulation of PTEN gene transcription	PE1	17
+NX_Q12874	Splicing factor 3A subunit 3	501	58849	5.27	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:8022796, PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277).	NA	Belongs to the SF3A3 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	1
+NX_Q12879	Glutamate receptor ionotropic, NMDA 2A	1464	165283	6.67	3	Dendritic spine;Cell membrane;Postsynaptic cell membrane;Cytoplasmic vesicle membrane;Synapse	Epilepsy, focal, with speech disorder and with or without mental retardation	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).	GRIN2A is phosphorylated by EPHB2 (Phosphotyrosine:PTM-0255)	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2A/GRIN2A subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Long-term potentiation;Glutamatergic synapse;Dopaminergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Systemic lupus erythematosus;Unblocking of NMDA receptors, glutamate binding and activation;Synaptic adhesion-like molecules;Neurexins and neuroligins;MECP2 regulates neuronal receptors and channels;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	16
+NX_Q12882	Dihydropyrimidine dehydrogenase [NADP(+)]	1025	111401	6.8	0	Cytoplasm	Dihydropyrimidine dehydrogenase deficiency	Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.	NA	Belongs to the dihydropyrimidine dehydrogenase family.	Amino-acid biosynthesis; beta-alanine biosynthesis.;Pyrimidine metabolism;beta-Alanine metabolism;Pantothenate and CoA biosynthesis;Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine catabolism	PE1	1
+NX_Q12884	Prolyl endopeptidase FAP	760	87713	6.21	1	Cytoplasm;Cell membrane;Secreted;Lamellipodium membrane;Cell surface;Membrane;Invadopodium membrane;Ruffle membrane	NA	Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.	The N-terminus may be blocked.;N-glycosylated.	Belongs to the peptidase S9B family.	NA	PE1	2
+NX_Q12887	Protoheme IX farnesyltransferase, mitochondrial	443	48910	9.36	7	Mitochondrion membrane;Cytosol;Mitochondrion;Nucleolus	Leigh syndrome;Mitochondrial complex IV deficiency	Converts protoheme IX and farnesyl diphosphate to heme O.	NA	Belongs to the UbiA prenyltransferase family.	Oxidative phosphorylation;Porphyrin and chlorophyll metabolism;Metabolic pathways;Heme biosynthesis	PE1	17
+NX_Q12888	TP53-binding protein 1	1972	213574	4.62	0	Nucleus;Kinetochore;Chromosome	NA	Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112).	Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.;Phosphorylated at basal level in the absence of DNA damage (PubMed:11042216, PubMed:11331310). Phosphorylated by ATM in response to DNA damage: phosphorylation at different sites promotes interaction with different set of proteins: phosphorylation at the N-terminus by ATM (residues from 6-178) promotes interaction with PAXIP1 and non-homologous end joining (NHEJ) of dysfunctional telomeres (PubMed:23727112). Phosphorylation by ATM at residues that are located more C-terminus (residues 300-650) leads to promote interaction with RIF1 (PubMed:23727112, PubMed:23333306, PubMed:28241136). Interaction with RIF1 leads to disrupt interaction with NUDT16L1/TIRR (PubMed:28241136). Phosphorylation at Thr-1609 and Ser-1618 in the UDR motif blocks interaction with H2AK15ub (PubMed:24703952). Dephosphorylated by PPP4C (PubMed:24703952). Hyperphosphorylation during mitosis correlates with its exclusion from chromatin and DNA lesions. Hyperphosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation (PubMed:17553757, PubMed:21144835). Dephosphorylated by PPP5C (PubMed:19176521).;TP53BP1 is phosphorylated by MAPK3	NA	G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);SUMOylation of transcription factors	PE1	15
+NX_Q12889	Oviduct-specific glycoprotein	678	75421	8.9	0	Secretory vesicle	NA	Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.	NA	Belongs to the glycosyl hydrolase 18 family.	Interaction With Cumulus Cells And The Zona Pellucida	PE1	1
+NX_Q12891	Hyaluronidase-2	473	53860	8.47	0	Cell membrane	NA	Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.	NA	Belongs to the glycosyl hydrolase 56 family.	Glycosaminoglycan degradation;Metabolic pathways;Hyaluronan uptake and degradation	PE1	3
+NX_Q12893	Transmembrane protein 115	351	38197	8.31	4	Golgi stack membrane;Golgi apparatus	NA	May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.	NA	Belongs to the TMEM115 family.	COPI-mediated anterograde transport	PE1	3
+NX_Q12894	Interferon-related developmental regulator 2	506	54814	8.21	0	NA	NA	NA	NA	Belongs to the IFRD family.	NA	PE1	3
+NX_Q12899	Tripartite motif-containing protein 26	539	62166	4.98	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.	Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction.	Belongs to the TRIM/RBCC family.	Interferon gamma signaling	PE1	6
+NX_Q12901	Zinc finger protein 155	538	62081	8.81	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q12904	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1	312	34353	8.61	0	Golgi apparatus;Secreted;Endoplasmic reticulum;Cytosol;Nucleus	Leukodystrophy, hypomyelinating, 3	Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550).	Cleaved by caspase-7 in response to apoptosis to produce EMAP-II.	NA	Cytosolic tRNA aminoacylation;Selenoamino acid metabolism	PE1	4
+NX_Q12905	Interleukin enhancer-binding factor 2	390	43062	5.19	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.	NA	NA	Neutrophil degranulation	PE1	1
+NX_Q12906	Interleukin enhancer-binding factor 3	894	95338	8.86	0	Cytoplasm;Mitochondrion;Nucleolus;Nucleoplasm;Nucleus	NA	RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).	Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.;Methylated by protein arginine N-methyltransferase 1.	NA	NA	PE1	19
+NX_Q12907	Vesicular integral-membrane protein VIP36	356	40229	6.46	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).	NA	NA	Protein processing in endoplasmic reticulum;COPII-mediated vesicle transport;Cargo concentration in the ER	PE1	5
+NX_Q12908	Ileal sodium/bile acid cotransporter	348	37714	6.79	7	Membrane	Primary bile acid malabsorption	Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.	NA	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.	Bile secretion;Recycling of bile acids and salts	PE1	13
+NX_Q12912	Lymphoid-restricted membrane protein	555	62122	5.62	1	Cytoplasm;Endoplasmic reticulum membrane;Chromosome;Membrane;Nucleoplasm;Spindle pole;Nucleus envelope;Centrosome;Cytoplasmic vesicle;Cytosol	NA	Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion.	The removal of the C-terminal lumenal domain occurs by proteolytic processing.	Belongs to the LRMP family.	Neutrophil degranulation	PE1	12
+NX_Q12913	Receptor-type tyrosine-protein phosphatase eta	1337	145941	5.38	1	Ruffle membrane;Cell junction;Cell membrane	NA	Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.	N- and O-glycosylated.	Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.	Adherens junction;Phosphorylation of CD3 and TCR zeta chains;Neutrophil degranulation;Negative regulation of MET activity	PE1	11
+NX_Q12918	Killer cell lectin-like receptor subfamily B member 1	225	25415	5.95	1	Membrane;Nucleoplasm;Cytosol	NA	Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.	N-glycosylated. Contains sialic acid residues.	NA	Malaria;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	12
+NX_Q12923	Tyrosine-protein phosphatase non-receptor type 13	2485	276906	5.99	0	Nucleolus;Nucleoplasm;Lamellipodium;Cytosol;Nucleus;Cytoskeleton	NA	Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.	Synthesis of PIPs at the plasma membrane;Interleukin-37 signaling	PE1	4
+NX_Q12926	ELAV-like protein 2	359	39504	9.22	0	NA	NA	RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity).	NA	Belongs to the RRM elav family.	mRNA Splicing - Major Pathway	PE1	9
+NX_Q12929	Epidermal growth factor receptor kinase substrate 8	822	91882	7.1	0	Golgi apparatus;Cell cortex;Synaptosome;Growth cone;Stereocilium;Ruffle membrane	Deafness, autosomal recessive, 102	Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.	Phosphorylation at Ser-625 and Thr-629 by MAPK following BDNF treatment promotes removal from actin and filopodia formation (By similarity). Phosphorylated by several receptor tyrosine kinases.;Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during G2 phase, leading to its transient degradation and subsequent cell shape changes required to allow mitotic progression. Reappears at the midzone of dividing cells (By similarity).	Belongs to the EPS8 family.	NA	PE1	12
+NX_Q12931	Heat shock protein 75 kDa, mitochondrial	704	80110	8.3	0	Mitochondrion matrix;Mitochondrion inner membrane;Mitochondrion	NA	Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.	TRAP1 is phosphorylated by SRC (Phosphotyrosine:PTM-0255)	Belongs to the heat shock protein 90 family.	Respiratory electron transport	PE1	16
+NX_Q12933	TNF receptor-associated factor 2	501	55859	7.66	0	Cytoplasm;Cytosol	NA	Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.	Phosphorylated at several serine residues within the first 128 amino acid residues. Phosphorylated at Thr-117 in response to signaling via TNF and TNFRSF1A. Phosphorylation at Thr-117 is required for 'Lys-63'-linked polyubiquitination, but not for 'Lys-48'-linked polyubiquitination. Phosphorylation at Thr-117 is important for interaction with IKKA and IKKB, activation of IKK and subsequent activation of NF-kappa-B.;Undergoes both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination. Polyubiquitinated via 'Lys-63'-linked ubiquitin in response to TNF signaling; this requires prior phosphorylation at Thr-117. 'Lys-63'-linked polyubiquitination promotes TRAF2-mediated activation of NF-kappa-B. Can be polyubiquitinated at several Lys residues via 'Lys-48'-linked ubiquitin chains in response to TNF signaling, leading to proteasomal degradation. Autoubiquitinated, leading to its subsequent proteasomal degradation. Polyubiquitinated by BIRC2 and SIAH2, leading to its subsequent proteasomal degradation. Deubiquitinated by CYLD, a protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains.	Belongs to the TNF receptor-associated factor family. A subfamily.	Protein modification; protein ubiquitination.;MAPK signaling pathway;Protein processing in endoplasmic reticulum;Apoptosis;Osteoclast differentiation;RIG-I-like receptor signaling pathway;Adipocytokine signaling pathway;Hepatitis C;Herpes simplex infection;Pathways in cancer;Small cell lung cancer;TNFR2 non-canonical NF-kB pathway;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;TNFR1-induced proapoptotic signaling;Caspase activation via Death Receptors in the presence of ligand;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TNF signaling;Regulation of necroptotic cell death;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases	PE1	9
+NX_Q12934	Filensin	665	74544	5.09	0	Cytosol;Cell cortex;Cytoskeleton;Cell membrane	Cataract 33, multiple types	NA	NA	Belongs to the intermediate filament family.	NA	PE1	20
+NX_Q12946	Forkhead box protein F1	379	40122	9.24	0	Nucleoplasm;Nucleus	Alveolar capillary dysplasia with misalignment of pulmonary veins	Probable transcription activator for a number of lung-specific genes.	NA	NA	NA	PE1	16
+NX_Q12947	Forkhead box protein F2	444	45993	9.2	0	Nucleus	NA	Probable transcription activator for a number of lung-specific genes (PubMed:8626802). Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (PubMed:29374064).	NA	NA	NA	PE1	6
+NX_Q12948	Forkhead box protein C1	553	56789	8.7	0	Nucleoplasm;Cytosol;Nucleus	Axenfeld-Rieger syndrome 3;Anterior segment dysgenesis 3	DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:15299087, PubMed:15684392, PubMed:16492674, PubMed:27907090, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:16449236, PubMed:17210863, PubMed:19793056, PubMed:19279310, PubMed:25786029, PubMed:27804176). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:7957066, PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176). Upon DNA-binding, promotes DNA bending (PubMed:7957066, PubMed:14506133). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963).	Sumoylated preferentially with SUMO2 or SUMO3 (PubMed:22493429). Desumoylated by SENP2 (PubMed:22493429).;Ubiquitinated, leading to its proteasomal degradation (PubMed:16492674).;Phosphorylated (PubMed:11782474, PubMed:19279310, PubMed:25786029). Phosphorylated on Ser-272 in response to epidermal growth factor (EGF) in a ERK1/2 MAPK-dependent signaling pathway; phosphorylation contributes to its protein stability and transcriptional activity (PubMed:16492674).	NA	NA	PE1	6
+NX_Q12950	Forkhead box protein D4	439	47309	9.38	0	Nucleus	NA	NA	NA	NA	NA	PE2	9
+NX_Q12951	Forkhead box protein I1	378	40973	5.89	0	Cytoplasmic vesicle;Nucleolus;Nucleus	NA	Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity).	NA	NA	NA	PE1	5
+NX_Q12952	Forkhead box protein L1	345	36490	9.64	0	Nucleus	NA	Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).	NA	NA	NA	PE1	16
+NX_Q12955	Ankyrin-3	4377	480410	6.07	0	Golgi apparatus;T-tubule;Cell membrane;Postsynaptic cell membrane;Lysosome;Axon;Sarcolemma;Cytoskeleton	Mental retardation, autosomal recessive 37	In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368).;May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.	NA	NA	Interaction between L1 and Ankyrins;COPI-mediated anterograde transport	PE1	10
+NX_Q12959	Disks large homolog 1	904	100455	5.51	0	Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Basolateral cell membrane;Cell junction;Membrane;Postsynaptic density;Synapse;Cytoplasmic vesicle;Apical cell membrane;Sarcolemma	NA	Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497).	Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A (By similarity).	Belongs to the MAGUK family.	T cell receptor signaling pathway;HTLV-I infection;RAF/MAP kinase cascade;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;Trafficking of AMPA receptors;NrCAM interactions;Activation of Ca-permeable Kainate Receptor;Synaptic adhesion-like molecules;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	3
+NX_Q12962	Transcription initiation factor TFIID subunit 10	218	21711	6.12	0	Nucleoplasm;Nucleus	NA	TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.	Lysine deamination at Lys-189 to form allysine is mediated by LOXL2. Allysine formation by LOXL2 results in release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription.;Monomethylated at Lys-189 by SETD7, leading to increased affinity for RNA polymerase II.	Belongs to the TAF10 family.	Basal transcription factors;Herpes simplex infection;HATs acetylate histones;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation;Ub-specific processing proteases	PE1	11
+NX_Q12965	Unconventional myosin-Ie	1108	127062	9.01	0	Cytoplasm;Clathrin-coated vesicle;Cell junction;Cytoplasmic vesicle;Cytoskeleton	Focal segmental glomerulosclerosis 6	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	15
+NX_Q12967	Ral guanine nucleotide dissociation stimulator	914	100607	5.52	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.	NA	NA	Pathways in cancer;Colorectal cancer;Pancreatic cancer;p38MAPK events	PE1	9
+NX_Q12968	Nuclear factor of activated T-cells, cytoplasmic 3	1075	115594	5.91	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Along with NFATC4, involved in embryonic heart development (By similarity).	Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.;NFATC3 is phosphorylated by CSNK1A1	NA	Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;HTLV-I infection;FCERI mediated Ca+2 mobilization;CLEC7A (Dectin-1) induces NFAT activation;Calcineurin activates NFAT	PE1	16
+NX_Q12972	Nuclear inhibitor of protein phosphatase 1	351	38479	6.87	0	Cytoplasm;Nucleoplasm;Nucleus speckle;Nucleus	NA	Is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.;Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.	May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity). Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA.	NA	NA	PE1	1
+NX_Q12974	Protein tyrosine phosphatase type IVA 2	167	19127	8.67	0	Cytoplasm;Early endosome;Cell membrane	NA	Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.	Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.	Belongs to the protein-tyrosine phosphatase family.	RAB geranylgeranylation	PE1	1
+NX_Q12979	Active breakpoint cluster region-related protein	859	97598	6.12	0	Dendritic spine;Nucleoplasm;Synapse;Cytosol;Axon	NA	Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity).	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	17
+NX_Q12980	GATOR complex protein NPRL3	569	63605	6.5	0	Cytosol;Lysosome membrane	Epilepsy, familial focal, with variable foci 3	As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.	NA	Belongs to the NPR3 family.	NA	PE1	16
+NX_Q12981	Vesicle transport protein SEC20	228	26132	9.06	1	Mitochondrion membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311). Plays also a role in apoptosis (PubMed:7954800, PubMed:15272311, PubMed:23896122). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).	Polyubiquitinated (PubMed:21931693, PubMed:23896122). 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1 (PubMed:21931693). Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion (PubMed:23896122).	Belongs to the SEC20 family.	SNARE interactions in vesicular transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	5
+NX_Q12982	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2	314	36018	4.7	0	Cytoplasm;Perinuclear region	NA	Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.	NA	NA	Myogenesis	PE1	15
+NX_Q12983	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3	259	27832	6.66	1	Mitochondrion outer membrane;Cytosol;Mitochondrion	NA	Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.	NA	Belongs to the NIP3 family.	Legionellosis	PE1	10
+NX_Q12986	Transcriptional repressor NF-X1	1120	124395	8.67	0	Nucleoplasm;Cytosol;Nucleus	NA	Binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.;Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma.	Is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation.;Is not polyubiquitinated.	Belongs to the NFX1 family.	NA	PE1	9
+NX_Q12988	Heat shock protein beta-3	150	16966	5.66	0	Cytoplasm;Nucleus speckle;Nucleus	Neuronopathy, distal hereditary motor, 2C	Inhibitor of actin polymerization.	NA	Belongs to the small heat shock protein (HSP20) family.	NA	PE1	5
+NX_Q12996	Cleavage stimulation factor subunit 3	717	82922	8.26	0	Nucleoplasm;Nucleus	NA	One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.	NA	NA	mRNA surveillance pathway;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	11
+NX_Q12999	Tetraspanin-31	210	23053	8.3	4	Golgi apparatus;Membrane;Nucleoplasm;Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	12
+NX_Q13002	Glutamate receptor ionotropic, kainate 2	908	102583	8.05	3	Cell membrane;Postsynaptic cell membrane	Mental retardation, autosomal recessive 6	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).	Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome (By similarity).;Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation.;Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1 (By similarity).	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;Activation of Ca-permeable Kainate Receptor;Activation of Na-permeable kainate receptors	PE1	6
+NX_Q13003	Glutamate receptor ionotropic, kainate 3	919	104037	7.28	3	Cell membrane;Postsynaptic cell membrane	NA	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.	NA	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;Presynaptic function of Kainate receptors;Activation of Ca-permeable Kainate Receptor	PE1	1
+NX_Q13007	Interleukin-24	206	23825	8.95	0	Secreted	NA	Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.	Ubiquitination at Lys-122 promotes proteasomal degradation.	Belongs to the IL-10 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling	PE1	1
+NX_Q13009	T-lymphoma invasion and metastasis-inducing protein 1	1591	177508	6.17	0	Cell membrane;Cell junction;Nucleus membrane;Nucleoplasm;Cytosol;Cytoskeleton	NA	Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.	NA	Belongs to the TIAM family.	Chemokine signaling pathway;Regulation of actin cytoskeleton;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;Activated NTRK2 signals through CDK5	PE1	21
+NX_Q13011	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial	328	35816	8.16	0	Peroxisome;Mitochondrion	NA	Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.	NA	Belongs to the enoyl-CoA hydratase/isomerase family.	Lipid metabolism; fatty acid beta-oxidation.;Peroxisome;Peroxisomal protein import	PE1	19
+NX_Q13015	Protein AF1q	90	10061	4.39	0	Cytoplasm;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312).	Ubiquitinated, leading to degradation.	Belongs to the MLLT11 family.	NA	PE1	1
+NX_Q13017	Rho GTPase-activating protein 5	1502	172460	6.18	0	Endoplasmic reticulum;Cytosol;Cytoplasm;Cell membrane	NA	GTPase-activating protein for Rho family members (PubMed:8537347).	NA	NA	Focal adhesion;Leukocyte transendothelial migration;Rho GTPase cycle	PE1	14
+NX_Q13018	Secretory phospholipase A2 receptor	1463	168600	5.73	1	Cytosol;Secreted;Cell membrane	NA	Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.	The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity).	NA	Phagosome;Tuberculosis;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI	PE1	2
+NX_Q13021	MAL-like protein	153	17350	6.15	4	Membrane	NA	NA	NA	Belongs to the MAL family.	NA	PE1	2
+NX_Q13023	A-kinase anchor protein 6	2319	256720	4.9	0	Sarcoplasmic reticulum;Nucleus membrane	NA	Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.	NA	NA	NA	PE1	14
+NX_Q13029	PR domain zinc finger protein 2	1718	188915	7.02	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE1	1
+NX_Q13033	Striatin-3	797	87209	5.17	0	Cytoplasm;Membrane;Nucleoplasm;Cytosol;Cytoskeleton	NA	Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.	NA	Belongs to the WD repeat striatin family.	NA	PE1	14
+NX_Q13042	Cell division cycle protein 16 homolog	620	71656	5.55	0	Cytoplasm;Spindle;Centrosome	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.	Belongs to the APC6/CDC16 family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	13
+NX_Q13043	Serine/threonine-protein kinase 4	487	55630	4.97	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.	Proteolytically cleaved by caspase-3 during apoptosis at Asp-326 and Asp-349 resulting in a 37 kDa or a 39 kDa subunit respectively. The 39 kDa subunit is further cleaved into the 37 kDa form. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N). It is less likely that cleavage at Asp-349 is a prerequisite for activation as this site is not conserved in the murine ortholog.;Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-387 by PKB/AKT1, leads to inhibition of its: kinase activity, nuclear translocation and autophosphorylation at Thr-183. It also diminishes its cleavage by caspases and its ability to phosphorylate FOXO3.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	MAPK signaling pathway;Pathways in cancer;Non-small cell lung cancer;Signaling by Hippo	PE1	20
+NX_Q13045	Protein flightless-1 homolog	1269	144751	5.75	0	Centriolar satellite;Focal adhesion;Nucleoplasm;Centrosome;Cytosol;Nucleus;Cytoskeleton	NA	May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.	NA	NA	NA	PE1	17
+NX_Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	419	47027	8.65	0	Secreted	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall	PE5	19
+NX_Q13049	E3 ubiquitin-protein ligase TRIM32	653	71989	6.59	0	Cytoplasm;Cytoskeleton	Muscular dystrophy, limb-girdle, autosomal recessive 8;Bardet-Biedl syndrome 11	Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.	Ubiquitinated.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Regulation of innate immune responses to cytosolic DNA	PE1	9
+NX_Q13057	Bifunctional coenzyme A synthase	564	62329	6.51	0	Cytoplasm;Mitochondrion matrix	Pontocerebellar hypoplasia 12;Neurodegeneration with brain iron accumulation 6	Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.	NA	In the central section; belongs to the eukaryotic CoaD family.	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.;Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.;Pantothenate and CoA biosynthesis;Metabolic pathways;Coenzyme A biosynthesis	PE1	17
+NX_Q13061	Triadin	729	81595	9.42	1	Cytosol;Sarcoplasmic reticulum membrane;Cell membrane	Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness	Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.	Phosphorylated by CaMK2.;N-glycosylated.	NA	Stimuli-sensing channels;Ion homeostasis	PE1	6
+NX_Q13064	Probable E3 ubiquitin-protein ligase makorin-3	507	55645	5.52	0	Nucleoplasm;Cytosol;Cell membrane	Precocious puberty, central 2	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	NA	NA	Protein modification; protein ubiquitination.	PE1	15
+NX_Q13065	G antigen 1	117	12885	4.12	0	NA	NA	Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis.	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q13066	G antigen 2B/2C	116	12786	4.34	0	NA	NA	Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q13069	G antigen 5	117	12924	4.19	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q13070	G antigen 6	117	12892	4.19	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q13072	B melanoma antigen 1	43	4810	5	0	Secreted	NA	Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.	NA	Belongs to the BAGE family.	NA	PE2	13
+NX_Q13075	Baculoviral IAP repeat-containing protein 1	1403	159582	5.68	0	NA	NA	Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.;Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.	NA	NA	NOD-like receptor signaling pathway;Legionellosis;NOD-like receptor signaling pathway;Legionellosis	PE1	5
+NX_Q13077	TNF receptor-associated factor 1	416	46164	5.77	0	Nucleoplasm;Cytoplasm	NA	Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.	Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.	NA	Herpes simplex infection;Pathways in cancer;Small cell lung cancer;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway	PE1	9
+NX_Q13084	39S ribosomal protein L28, mitochondrial	256	30157	8.34	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bL28 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	16
+NX_Q13085	Acetyl-CoA carboxylase 1	2346	265554	5.95	0	Cytoplasm;Cytosol;Nucleolus;Cytoskeleton	Acetyl-CoA carboxylase 1 deficiency	Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA, a key metabolite in the fatty acid synthetic (PubMed:20952656, PubMed:20457939). Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (PubMed:20952656, PubMed:20457939).	Phosphorylation on Ser-1263 is required for interaction with BRCA1.	NA	Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.;Fatty acid biosynthesis;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Insulin signaling pathway;ChREBP activates metabolic gene expression;Activation of gene expression by SREBF (SREBP);Import of palmitoyl-CoA into the mitochondrial matrix;Biotin transport and metabolism;Defective HLCS causes multiple carboxylase deficiency;Fatty acyl-CoA biosynthesis	PE1	17
+NX_Q13087	Protein disulfide-isomerase A2	525	58206	4.89	0	Endoplasmic reticulum lumen	NA	Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.	Glycosylated.;The disulfide-linked homodimer exhibits an enhanced chaperone activity.	Belongs to the protein disulfide isomerase family.	NA	PE1	16
+NX_Q13093	Platelet-activating factor acetylhydrolase	441	50077	7.23	0	Extracellular space	Asthma;Platelet-activating factor acetylhydrolase deficiency;Atopic hypersensitivity	Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Ether lipid metabolism;Metabolic pathways;Synthesis, secretion, and deacylation of Ghrelin	PE1	6
+NX_Q13094	Lymphocyte cytosolic protein 2	533	60188	5.89	0	Cytoplasm	NA	Involved in T-cell antigen receptor mediated signaling.	Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components.;LCP2 is phosphorylated by ZAP70 (Phosphotyrosine:PTM-0255)	NA	Osteoclast differentiation;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Generation of second messenger molecules;GPVI-mediated activation cascade;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization	PE1	5
+NX_Q13098	COP9 signalosome complex subunit 1	491	55537	6.3	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.	NA	Belongs to the CSN1 family.	Formation of TC-NER Pre-Incision Complex;DNA Damage Recognition in GG-NER;Cargo recognition for clathrin-mediated endocytosis;Neddylation	PE1	17
+NX_Q13099	Intraflagellar transport protein 88 homolog	833	94270	6.2	0	Cytoplasm;Centriole;Cilium;Cilium basal body;Centrosome;Flagellum	NA	Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.	NA	NA	Intraflagellar transport;Hedgehog 'off' state	PE1	13
+NX_Q13103	Secreted phosphoprotein 24	211	24338	8.59	0	Secreted	NA	Could coordinate an aspect of bone turnover.	Phosphorylation sites are present in the extracellular medium.	Belongs to the SPP2 family.	Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	2
+NX_Q13105	Zinc finger and BTB domain-containing protein 17	803	87928	6	0	Nucleus	NA	Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).	Undergoes 'Lys-48'-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner.	Belongs to the krueppel C2H2-type zinc-finger protein family.	XBP1(S) activates chaperone genes	PE1	1
+NX_Q13106	Zinc finger protein 154	437	49865	9.11	0	Nucleoplasm;Nucleus;Nucleolus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q13107	Ubiquitin carboxyl-terminal hydrolase 4	963	108565	5.47	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403). Deubiquitinates PDPK1 (PubMed:22347420). Deubiquitinates TRIM21 (PubMed:16316627). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234). May also play a role in the regulation of quality control in the ER (PubMed:16339847).	Monoubiquitinated by TRIM21. Ubiquitination does not lead to its proteasomal degradation. Autodeubiquitinated.	Belongs to the peptidase C19 family. USP4 subfamily.	TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases	PE1	3
+NX_Q13111	Chromatin assembly factor 1 subunit A	956	106910	5.69	0	Nucleoplasm;Cytosol;Nucleus	NA	Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity).	NA	Belongs to the CHAF1A family.	NA	PE1	19
+NX_Q13112	Chromatin assembly factor 1 subunit B	559	61493	7.18	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.	Differentially phosphorylated during cell cycle. During mitosis the p60 subunit of inactive CAF-1 is hyperphosphorylated and displaced into the cytosol. Progressivly dephosphorylated from G1 to S and G2 phase. Phosphorylated p60 is recruited to chromatin undergoing DNA repair after UV irradiation in G1, S or G2 phases.	Belongs to the WD repeat HIR1 family.	NA	PE1	21
+NX_Q13113	PDZK1-interacting protein 1	114	12227	4.79	1	Membrane;Cytosol;Nucleus speckle	NA	May play an important role in tumor biology.	NA	NA	NA	PE1	1
+NX_Q13114	TNF receptor-associated factor 3	568	64490	8.23	0	Cytoplasm;Endosome;Mitochondrion	Encephalopathy, acute, infection-induced, Herpes-specific, 5	Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.	Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40. 'Lys-48'-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Undergoes 'Lys-63'-linked ubiquitination during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling. Deubiquitinated by OTUB1, OTUB2 and OTUD5.	Belongs to the TNF receptor-associated factor family. A subfamily.	Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Hepatitis C;Herpes simplex infection;Pathways in cancer;Small cell lung cancer;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;Negative regulators of DDX58/IFIH1 signaling;TRAF3-dependent IRF activation pathway;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;TRAF3 deficiency - HSE;Ovarian tumor domain proteases;TICAM1-dependent activation of IRF3/IRF7	PE1	14
+NX_Q13115	Dual specificity protein phosphatase 4	394	42953	7.1	0	Nucleoplasm;Nucleus	NA	Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.	Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein.	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway;RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway;ERKs are inactivated	PE1	8
+NX_Q13117	Deleted in azoospermia protein 2	558	63111	8.84	0	Cytoplasm;Nucleus	Spermatogenic failure Y-linked 2	RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.	NA	Belongs to the RRM DAZ family.	NA	PE1	Y
+NX_Q13118	Krueppel-like factor 10	480	52555	9.29	0	Nucleus	NA	Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.	Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_Q13123	Protein Red	557	65602	6.26	0	Nucleus speckle;Chromosome;Nucleoplasm;Spindle pole;Nucleus	NA	Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353).;(Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.	NA	Belongs to the RED family.	NA	PE1	5
+NX_Q13126	S-methyl-5'-thioadenosine phosphorylase	283	31236	6.75	0	Cytoplasm;Cytosol;Nucleus	Diaphyseal medullary stenosis with malignant fibrous histiocytoma	Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	NA	Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.	Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.;Cysteine and methionine metabolism;Metabolic pathways;Methionine salvage pathway;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	9
+NX_Q13127	RE1-silencing transcription factor	1097	121872	6.3	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	Fibromatosis, gingival, 5;Wilms tumor 6	Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247, PubMed:11741002, PubMed:11779185). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433).;Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity).	Ubiquitinated; ubiquitination is mediated by BTRC and leads to proteasomal degradation in G2 phase (PubMed:18354482, PubMed:21258371). Ubiquitination increases during neuronal differentiation (PubMed:21258371). Deubiquitinated by USP7; leading to its stabilization and promoting the maintenance of neural progenitor cells (PubMed:21258371).;Phosphorylated; phosphorylation is required for ubiquitination.;O-glycosylated.	NA	HDACs deacetylate histones;Regulation of PTEN gene transcription	PE1	4
+NX_Q13129	Zinc finger protein Rlf	1914	217953	6.32	0	Nucleoplasm;Nucleus;Nucleolus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_Q13131	5'-AMP-activated protein kinase catalytic subunit alpha-1	559	64009	8.32	0	Cytoplasm;Nucleus speckle;Nucleus	NA	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. In that process also activates WDR45 (PubMed:28561066). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.	Ubiquitinated.;Phosphorylated at Thr-183 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-183 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-183, but at a much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. Dephosphorylated by PPM1A and PPM1B.;PRKAA1 is phosphorylated by ULK2	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	Regulation of autophagy;mTOR signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Hypertrophic cardiomyopathy (HCM);Macroautophagy;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs	PE1	5
+NX_Q13133	Oxysterols receptor LXR-alpha	447	50396	7.61	0	Cytoplasm;Nucleus	NA	Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).	Ubiquitinated leading to its degradation by the proteasome.	Belongs to the nuclear hormone receptor family. NR1 subfamily.	PPAR signaling pathway;Hepatitis C;PPARA activates gene expression;Nuclear Receptor transcription pathway;VLDLR internalisation and degradation;SUMOylation of intracellular receptors	PE1	11
+NX_Q13136	Liprin-alpha-1	1202	135779	5.91	0	Cytoplasm;Cytosol;Focal adhesion	NA	May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.	NA	Belongs to the liprin family. Liprin-alpha subfamily.	Acetylcholine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Receptor-type tyrosine-protein phosphatases	PE1	11
+NX_Q13137	Calcium-binding and coiled-coil domain-containing protein 2	446	52254	4.94	0	Autophagosome membrane;Cytoplasm;Cytoplasmic vesicle;Cytosol;Perinuclear region;Nucleus;Cytoskeleton	NA	Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).	NA	Belongs to the CALCOCO family.	NA	PE1	17
+NX_Q13144	Translation initiation factor eIF-2B subunit epsilon	721	80380	4.98	0	Cytosol	Leukodystrophy with vanishing white matter	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.	Polyubiquitinated, probably by NEDD4.;Phosphorylated at Ser-544 by DYRK2; this is required for subsequent phosphorylation by GSK3B (By similarity). Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function.;EIF2B5 is phosphorylated by DYRK1A (Phosphoserine:PTM-0253)	Belongs to the eIF-2B gamma/epsilon subunits family.	RNA transport;Recycling of eIF2:GDP	PE1	3
+NX_Q13145	BMP and activin membrane-bound inhibitor homolog	260	29108	7.91	1	Membrane;Cytoplasmic vesicle;Nucleolus;Lipid droplet	NA	Negatively regulates TGF-beta signaling.	NA	Belongs to the BAMBI family.	Downregulation of TGF-beta receptor signaling	PE1	10
+NX_Q13148	TAR DNA-binding protein 43	414	44740	5.85	0	Nucleoplasm;Stress granule;Cytoplasm;Nucleus	Amyotrophic lateral sclerosis 10	RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:23398327, PubMed:19765185). Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980).	Hyperphosphorylated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU. Phosphorylated upon cellular stress.;Ubiquitinated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.;Cleaved to generate C-terminal fragments in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.	NA	NA	PE1	1
+NX_Q13151	Heterogeneous nuclear ribonucleoprotein A0	305	30841	9.34	0	Nucleoplasm;Nucleus	NA	MRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.	Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.;Arg-291 is dimethylated, probably to asymmetric dimethylarginine.;HNRNPA0 is phosphorylated by MKNK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA	PE1	5
+NX_Q13153	Serine/threonine-protein kinase PAK 1	545	60647	5.55	0	Cytoplasm;Invadopodium;Cell membrane;Focal adhesion;Chromosome;Nucleoplasm;Ruffle membrane;Cytosol	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:30290153). Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation. Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667).	Autophosphorylated in trans, meaning that in a dimer, one kinase molecule phosphorylates the other one. Activated by autophosphorylation at Thr-423 in response to a conformation change, triggered by interaction with GTP-bound CDC42 or RAC1. Activated by phosphorylation at Thr-423 by BRSK2 and by PDPK1. Phosphorylated by JAK2 in response to PRL; this increases PAK1 kinase activity. Phosphorylated at Ser-21 by PKB/AKT; this reduces interaction with NCK1 and association with focal adhesion sites. Upon DNA damage, phosphorylated at Thr-212 and translocates to the nucleoplasm (PubMed:23260667). Phosphorylated at tyrosine residues, which can be enhanced by NTN1 (By similarity).;PAK1 is phosphorylated by BMX (Phosphotyrosine:PTM-0255);PAK1 is phosphorylated by PDPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;Axon guidance;Focal adhesion;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Epithelial cell signaling in Helicobacter pylori infection;Renal cell carcinoma;MAPK6/MAPK4 signaling;Regulation of actin dynamics for phagocytic cup formation;DSCAM interactions;Generation of second messenger molecules;EPHB-mediated forward signaling;Ephrin signaling;FCERI mediated MAPK activation;Signal transduction by L1;VEGFR2 mediated vascular permeability;CD28 dependent Vav1 pathway;Sema3A PAK dependent Axon repulsion;CD209 (DC-SIGN) signaling;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs;Activation of RAC1;G beta:gamma signalling through CDC42	PE1	11
+NX_Q13155	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	320	35349	8.45	0	Cytosol;Nucleus	Leukodystrophy, hypomyelinating, 17	Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.	Ubiquitinated by PRKN, leading to its degradation by the proteasome. Mutant PRKN fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.;Phosphorylated on serine residues in response to UV irradiation.	NA	Cytosolic tRNA aminoacylation;Selenoamino acid metabolism	PE1	7
+NX_Q13156	Replication protein A 30 kDa subunit	261	28868	6.07	0	Nucleus	NA	As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.	NA	Belongs to the replication factor A protein 2 family.	DNA replication;Nucleotide excision repair;Mismatch repair;Homologous recombination;Fanconi anemia pathway;Activation of the pre-replicative complex	PE1	X
+NX_Q13158	FAS-associated death domain protein	208	23279	5.48	0	Nucleoplasm;Cytosol	Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations	Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	NA	NA	Apoptosis;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Alzheimer's disease;Chagas disease (American trypanosomiasis);Tuberculosis;Herpes simplex infection;Pathways in cancer;TNFR1-induced proapoptotic signaling;Caspase activation via Death Receptors in the presence of ligand;TRIF-mediated programmed cell death;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TRAIL signaling;FasL/ CD95L signaling;TLR3-mediated TICAM1-dependent programmed cell death	PE1	11
+NX_Q13162	Peroxiredoxin-4	271	30540	5.86	0	Endoplasmic reticulum;Cytoplasm;Cytosol	NA	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.	The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.	Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.	Neutrophil degranulation	PE1	X
+NX_Q13163	Dual specificity mitogen-activated protein kinase kinase 5	448	50112	5.98	0	Nucleolus;Cytoskeleton	NA	Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.	Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.;Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.;MAP2K5 is phosphorylated by MAPK6	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	MAPK signaling pathway;Gap junction;Neurotrophin signaling pathway;Signalling to ERK5	PE1	15
+NX_Q13164	Mitogen-activated protein kinase 7	816	88386	5.6	0	Cytoplasm;Nucleoplasm;PML body;Cytosol;Nucleus	NA	Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.	Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK signaling pathway;Gap junction;Neurotrophin signaling pathway;GnRH signaling pathway;Senescence-Associated Secretory Phenotype (SASP);Gastrin-CREB signalling pathway via PKC and MAPK;ERK/MAPK targets;ERKs are inactivated;Signalling to ERK5;RET signaling	PE1	17
+NX_Q13166	CATR tumorigenic conversion 1 protein	79	9224	8	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_Q13177	Serine/threonine-protein kinase PAK 2	524	58043	5.69	0	Cytoplasm;Membrane;Nucleoplasm;Cytoplasmic vesicle;Perinuclear region;Nucleus	NA	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.	During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34.;Ubiquitinated, leading to its proteasomal degradation.;PAK-2p34 is myristoylated.;Full-length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated, with PAK-2p27 being phosphorylated on serine and PAK-2p34 on threonine residues, respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PAK2 is phosphorylated by FYN (Phosphotyrosine:PTM-0255);PAK2 is phosphorylated by SYK (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	MAPK signaling pathway;ErbB signaling pathway;Axon guidance;Focal adhesion;T cell receptor signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;Regulation of activated PAK-2p34 by proteasome mediated degradation;MAPK6/MAPK4 signaling;Generation of second messenger molecules;Ephrin signaling;FCERI mediated MAPK activation;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;CD28 dependent Vav1 pathway;Sema3A PAK dependent Axon repulsion;CD209 (DC-SIGN) signaling;Nef and signal transduction;Smooth Muscle Contraction;RHO GTPases activate PAKs;Activation of RAC1;Regulation of PAK-2p34 activity by PS-GAP/RHG10;Stimulation of the cell death response by PAK-2p34;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	3
+NX_Q13183	Solute carrier family 13 member 2	592	64410	6.55	12	Membrane	NA	Cotransport of sodium ions and dicarboxylates such as succinate and citrate.	NA	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.	Sodium-coupled sulphate, di- and tri-carboxylate transporters	PE1	17
+NX_Q13185	Chromobox protein homolog 3	183	20811	5.23	0	Nucleoplasm;Nucleus	NA	Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).	Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.;CBX3 is phosphorylated by PIM1 (Phosphoserine:PTM-0253)	NA	RNA Polymerase I Promoter Escape;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Transcriptional Regulation by E2F6	PE1	7
+NX_Q13188	Serine/threonine-protein kinase 3	491	56301	5.12	0	Cytoplasm;Nucleus;Cytoskeleton	NA	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38.	Phosphorylation at Thr-117 and Thr-384 by PKB/AKT1, leads to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation, and increase in its binding to RAF1.;Proteolytically cleaved by caspase-3 during apoptosis. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N).	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	MAPK signaling pathway;Signaling by Hippo	PE1	8
+NX_Q13190	Syntaxin-5	355	39673	9.21	1	Golgi apparatus;Nucleoplasm;Endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi apparatus membrane	NA	Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.	NA	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;COPII-mediated vesicle transport;Cargo concentration in the ER;Intra-Golgi traffic;COPI-mediated anterograde transport;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	11
+NX_Q13191	E3 ubiquitin-protein ligase CBL-B	982	109450	8.15	0	Nucleoplasm;Cytosol;Cytoplasm	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).	Auto-ubiquitinated upon EGF-mediated cell activation or upon T-cell costimulation by CD28; which promotes proteasomal degradation.;Phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation.	NA	Protein modification; protein ubiquitination.;ErbB signaling pathway;Ubiquitin mediated proteolysis;Endocytosis;Jak-STAT signaling pathway;T cell receptor signaling pathway;Insulin signaling pathway;Bacterial invasion of epithelial cells;Measles;Pathways in cancer;Chronic myeloid leukemia;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	3
+NX_Q13200	26S proteasome non-ATPase regulatory subunit 2	908	100200	5.08	0	NA	NA	Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.;Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.	NA	Belongs to the proteasome subunit S2 family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	3
+NX_Q13201	Multimerin-1	1228	138110	8.15	0	Endoplasmic reticulum;Secreted	NA	Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein.	The N-terminus is blocked.;Extensively N-glycosylated.	NA	Platelet degranulation	PE1	4
+NX_Q13202	Dual specificity protein phosphatase 8	625	65827	8.58	0	Cytoplasm;Cytosol;Nucleus	NA	Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway;RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway	PE1	11
+NX_Q13203	Myosin-binding protein H	477	52050	6.3	0	Nucleoplasm;Mitochondrion;Nucleolus	NA	Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.	NA	Belongs to the immunoglobulin superfamily. MyBP family.	NA	PE1	1
+NX_Q13206	Probable ATP-dependent RNA helicase DDX10	875	100888	8.72	0	Cytoplasm;Nucleus;Nucleolus	NA	Putative ATP-dependent RNA helicase.	NA	Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.	NA	PE1	11
+NX_Q13207	T-box transcription factor TBX2	712	75066	9.13	0	Nucleoplasm;Cytosol;Nucleus	Vertebral anomalies and variable endocrine and T-cell dysfunction	Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation.	NA	NA	NA	PE1	17
+NX_Q13214	Semaphorin-3B	749	83122	9.17	0	Endoplasmic reticulum;Secreted	NA	Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.	NA	Belongs to the semaphorin family.	Axon guidance	PE1	3
+NX_Q13216	DNA excision repair protein ERCC-8	396	44055	5.91	0	Nucleus matrix;Nucleus speckle;Nucleus	UV-sensitive syndrome 2;Cockayne syndrome A	Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair; involved in repair of DSSBs by non-homologous end joining (NHEJ) (PubMed:29545921).	NA	NA	Protein modification; protein ubiquitination.;Nucleotide excision repair;Ubiquitin mediated proteolysis;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Neddylation	PE1	5
+NX_Q13217	DnaJ homolog subfamily C member 3	504	57580	5.83	0	Endoplasmic reticulum	Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.	NA	NA	Protein processing in endoplasmic reticulum;Influenza A;XBP1(S) activates chaperone genes;Viral mRNA Translation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation	PE1	13
+NX_Q13219	Pappalysin-1	1627	180973	5.76	0	Secreted	NA	Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.	There appear to be no free sulfhydryl groups.	Belongs to the peptidase M43B family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	PE1	9
+NX_Q13224	Glutamate receptor ionotropic, NMDA 2B	1484	166367	6.47	3	Cell membrane;Postsynaptic cell membrane	Epileptic encephalopathy, early infantile, 27;Mental retardation, autosomal dominant 6, with or without seizures	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).	Phosphorylated on tyrosine residues (By similarity). Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (By similarity).	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily.	Neuroactive ligand-receptor interaction;Long-term potentiation;Glutamatergic synapse;Dopaminergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Systemic lupus erythematosus;RAF/MAP kinase cascade;EPHB-mediated forward signaling;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;Synaptic adhesion-like molecules;Neurexins and neuroligins;Activated NTRK2 signals through FYN;MECP2 regulates neuronal receptors and channels;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	12
+NX_Q13227	G protein pathway suppressor 2	327	36689	9.52	0	Nucleoplasm;Cytosol;Mitochondrion;Nucleus	NA	Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:19858209, PubMed:24943844). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (PubMed:20159957). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (By similarity). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the proinflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity (By similarity). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (By similarity). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). Acts as a tumor-suppressor in liposarcoma (PubMed:27460081).;(Microbial infection) Required for efficient replication of hepatitis C virus (HCV) by promoting the interaction between VAPA and HCV virus protein NS5A.	Methylated at Arg-312 and Arg-323 by PRMT6. Methylation at Arg-323 protects from degradation by the proteasome.;Ubiquitinated at the C-terminus by SIAH2; leading to its degradation by the proteasome. Interaction with TBL1X and methylation at Arg-323 protect GPS2 against ubiquitination and degradation.;Sumoylation regulates its subcellular location (PubMed:24943844). Sumoylation at Lys-45 and Lys-71 regulates the shuttling between the cytoplasm and the nucleus (PubMed:24943844). Sumoylation at Lys-71 is required for interaction with TBL1X (By similarity). Sumoylated at Lys-45 and Lys-71 in mitochondrion (By similarity). Desumoylation by SENP1 leads to relocation from the mitochondria to the nucleus (By similarity).	NA	HTLV-I infection;PPARA activates gene expression;HDACs deacetylate histones;Regulation of MECP2 expression and activity;Loss of MECP2 binding ability to the NCoR/SMRT complex	PE1	17
+NX_Q13228	Methanethiol oxidase	472	52391	5.93	0	Membrane;Nucleus;Nucleolus;Cytosol	Extraoral halitosis due to methanethiol oxidase deficiency	Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).	The N-terminus is blocked.;Phosphorylated.	Belongs to the selenium-binding protein family.	Organosulfur degradation.	PE1	1
+NX_Q13231	Chitotriosidase-1	466	51681	6.55	0	Secreted;Lysosome	NA	Has no enzymatic activity.;Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens.	NA	Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.	Amino sugar and nucleotide sugar metabolism;Digestion of dietary carbohydrate;Neutrophil degranulation	PE1	1
+NX_Q13232	Nucleoside diphosphate kinase 3	169	19015	7.71	0	Nucleoplasm;Cytosol	NA	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.	NA	Belongs to the NDK family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	16
+NX_Q13233	Mitogen-activated protein kinase kinase kinase 1	1512	164470	7.93	0	Cytosol	46,XY sex reversal 6	Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).	Autophosphorylated.;MAP3K1 is phosphorylated by MAP4K2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway;Ubiquitin mediated proteolysis;RIG-I-like receptor signaling pathway;Neurotrophin signaling pathway;GnRH signaling pathway;HTLV-I infection;FCERI mediated MAPK activation;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;TRAF6 mediated NF-kB activation;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 cascade initiated on plasma membrane	PE1	5
+NX_Q13237	cGMP-dependent protein kinase 2	762	87432	8.67	0	Apical cell membrane	NA	Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).	Myristoylation mediates membrane localization.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.	Gap junction;Long-term depression;Olfactory transduction;Salivary secretion;Ca2+ pathway;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;cGMP effects	PE1	4
+NX_Q13239	Src-like-adapter	276	31156	7.61	0	Cytoplasm;Endosome	NA	Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.	SLA is phosphorylated by KIT	NA	NA	PE1	8
+NX_Q13241	Natural killer cells antigen CD94	179	20513	5.19	1	Cell membrane	NA	Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	NA	NA	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Graft-versus-host disease;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 signaling;DAP12 interactions	PE1	12
+NX_Q13242	Serine/arginine-rich splicing factor 9	221	25542	8.74	0	Nucleoplasm;Nucleolus;Nucleus	NA	Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.	Extensively phosphorylated on serine residues in the RS domain.	Belongs to the splicing factor SR family.	Spliceosome;Herpes simplex infection;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	12
+NX_Q13243	Serine/arginine-rich splicing factor 5	272	31264	11.59	0	Nucleus;Nucleoplasm;Cytosol;Nucleolus	NA	Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.	Extensively phosphorylated on serine residues in the RS domain.;SRSF5 is phosphorylated by CLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRSF5 is phosphorylated by CLK4 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRSF5 is phosphorylated by SRPK1 (Phosphoserine:PTM-0253);SRSF5 is phosphorylated by SRPK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the splicing factor SR family.	Spliceosome;Herpes simplex infection;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	14
+NX_Q13247	Serine/arginine-rich splicing factor 6	344	39587	11.42	0	Nucleus speckle;Nucleus	NA	Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.	Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10.;SRSF6 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRSF6 is phosphorylated by CLK4;SRSF6 is phosphorylated by CLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRSF6 is phosphorylated by SRPK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SRSF6 is phosphorylated by SRPK1 (Phosphoserine:PTM-0253)	Belongs to the splicing factor SR family.	Spliceosome;Herpes simplex infection;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	20
+NX_Q13253	Noggin	232	25774	9.13	0	Secreted	Stapes ankylosis with broad thumb and toes;Tarsal-carpal coalition syndrome;Multiple synostoses syndrome 1;Symphalangism, proximal 1A;Brachydactyly B2	Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732).	NA	Belongs to the noggin family.	TGF-beta signaling pathway;Signaling by BMP	PE1	17
+NX_Q13255	Metabotropic glutamate receptor 1	1194	132357	6.27	7	Cytoplasmic vesicle;Cell membrane	Spinocerebellar ataxia 44;Spinocerebellar ataxia, autosomal recessive, 13	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890). May function in the light response in the retina (By similarity).	NA	Belongs to the G-protein coupled receptor 3 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Gap junction;Long-term potentiation;Glutamatergic synapse;Long-term depression;Huntington's disease;G alpha (q) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors);Neurexins and neuroligins	PE1	6
+NX_Q13257	Mitotic spindle assembly checkpoint protein MAD2A	205	23510	5.02	0	Kinetochore;Cytoplasm;Nucleoplasm;Spindle pole;Nucleus	NA	Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.	Phosphorylated on multiple serine residues. The level of phosphorylation varies during the cell cycle and is highest during mitosis. Phosphorylation abolishes interaction with MAD1L1 and reduces interaction with CDC20. Phosphorylated by NEK2.;MAD2L1 is phosphorylated by NEK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the MAD2 family.	Cell cycle;Oocyte meiosis;Progesterone-mediated oocyte maturation;HTLV-I infection;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of mitotic proteins;APC-Cdc20 mediated degradation of Nek2A;Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	4
+NX_Q13258	Prostaglandin D2 receptor	359	40271	9.39	7	Cell membrane	Asthma-related traits 1	Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Prostanoid ligand receptors	PE1	14
+NX_Q13261	Interleukin-15 receptor subunit alpha	267	28233	8.64	1	Endoplasmic reticulum membrane;Nucleus membrane;Membrane;Cell surface;Golgi apparatus membrane;Cytoplasmic vesicle membrane;Extracellular space	NA	High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910).;Does not bind IL15.;Does not bind IL15.;Does not bind IL15.;Does not bind IL15.	A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (PubMed:15265897). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor (PubMed:15265897).;N-glycosylated and O-glycosylated.	NA	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Intestinal immune network for IgA production;HTLV-I infection;Interleukin-15 signaling	PE1	10
+NX_Q13263	Transcription intermediary factor 1-beta	835	88550	5.52	0	Nucleoplasm;Nucleus	NA	(Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1.;Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity).	Citrullinated by PADI4.;ATM-induced phosphorylation on Ser-824 represses sumoylation leading to the de-repression of expression of a subset of genes involved in cell cycle control and apoptosis in response to genotoxic stress. Dephosphorylation by the phosphatases, PPP1CA and PP1CB forms, allows sumoylation and expression of TRIM28 target genes.;Auto-ubiquitinated; enhanced by MAGEA2 and MAGEC2.;Sumoylation/desumoylation events regulate TRIM28-mediated transcriptional repression. Sumoylation is required for interaction with CHD3 and SETDB1 and the corepressor activity. Represses and is repressed by Ser-824 phosphorylation. Enhances the TRIM28 corepressor activity, inhibiting transcriptional activity of a number of genes including GADD45A and CDKN1A/p21. Lys-554, Lys-779 and Lys-804 are the major sites of sumoylation. In response to Dox-induced DNA damage, enhanced phosphorylation on Ser-824 prevents sumoylation and allows de-repression of CDKN1A/p21.;TRIM28 is phosphorylated by FES (Phosphotyrosine:PTM-0255)	Belongs to the TRIM/RBCC family.	Protein modification; protein sumoylation.;Generic Transcription Pathway;SUMOylation of transcription cofactors	PE1	19
+NX_Q13268	Dehydrogenase/reductase SDR family member 2, mitochondrial	280	29927	9.21	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion;Nucleus	NA	Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	NA	PE1	14
+NX_Q13275	Semaphorin-3F	785	88381	8.59	0	Secreted	NA	May play a role in cell motility and cell adhesion.	NA	Belongs to the semaphorin family.	Axon guidance	PE1	3
+NX_Q13277	Syntaxin-3	289	33155	5.31	1	Membrane;Nucleoplasm;Nucleus	NA	Potentially involved in docking of synaptic vesicles at presynaptic active zones.	NA	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;Synaptic vesicle cycle;Other interleukin signaling	PE1	11
+NX_Q13278	Putative protein RIG	110	11984	8.36	0	NA	NA	May serve as a molecular marker for or play a role in the malignant progression of glioblastomas.	NA	NA	NA	PE5	11
+NX_Q13283	Ras GTPase-activating protein-binding protein 1	466	52164	5.36	0	Cytoplasm;Stress granule;Cell membrane;Perikaryon;Cytosol;Nucleus	NA	ATP- and magnesium-dependent helicase that plays an essential role in innate immunity (PubMed:30510222). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA (PubMed:30804210). In addition, plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510). Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510).	Phosphorylated exclusively on serine residues. Hyperphosphorylated in quiescent fibroblasts. Hypophosphorylation leads to a decrease in endoribonuclease activity (By similarity). RASA1-dependent phosphorylation of Ser-149 induces a conformational change that prevents self-association. Dephosphorylation after HRAS activation is required for stress granule assembly. Ser-149 phosphorylation induces partial nuclear localization.;(Microbial infection) Cleaved by human enterovirus 71; this cleavage induces the disassembly of cytoplasmic stress granules (PubMed:30006004). Cleaved by Foot-and-mouth disease virus; this cleavage suppresses the formation of cytoplasmic stress granules (PubMed:30404792).;Arg-435 is dimethylated, probably to asymmetric dimethylarginine.	NA	NA	PE1	5
+NX_Q13285	Steroidogenic factor 1	461	51636	7.81	0	Nucleus	Adrenal insufficiency, NR5A1-related;Premature ovarian failure 7;46,XX sex reversal 4;46,XY sex reversal 3;Spermatogenic failure 8	Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.	Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity.;Acetylation stimulates the transcriptional activity.;Sumoylation reduces CDK7-mediated phosphorylation on Ser-203.	Belongs to the nuclear hormone receptor family. NR5 subfamily.	Transcriptional regulation of pluripotent stem cells;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors	PE1	9
+NX_Q13286	Battenin	438	47623	5.93	6	Lysosome membrane;Late endosome;Lysosome	Ceroid lipofuscinosis, neuronal, 3	Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Farnesylation is important for trafficking to lysosomes.;Highly glycosylated.	Belongs to the battenin family.	Lysosome	PE1	16
+NX_Q13287	N-myc-interactor	307	35057	5.24	0	Nucleoplasm;Cytoplasm;Cytosol	NA	May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.	NA	Belongs to the NMI family.	NA	PE1	2
+NX_Q13291	Signaling lymphocytic activation molecule	335	37231	8.7	1	Secreted;Cell membrane	NA	(Microbial infection) Acts as a receptor for Measles virus; also including isoform 4.;Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity). Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396).	Phosphorylated on tyrosine residues by FYN.	NA	Measles	PE1	1
+NX_Q13296	Mammaglobin-A	93	10499	4.17	0	Secreted	NA	NA	NA	Belongs to the secretoglobin family. Lipophilin subfamily.	NA	PE1	11
+NX_Q13303	Voltage-gated potassium channel subunit beta-2	367	41000	9.11	0	Cytoplasm;Cell membrane;Synaptosome;Membrane;Axon;Cytoskeleton	NA	Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity).	Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1.	Belongs to the shaker potassium channel beta subunit family.	Voltage gated Potassium channels;Neutrophil degranulation	PE1	1
+NX_Q13304	Uracil nucleotide/cysteinyl leukotriene receptor	367	40989	9.58	7	Cytoplasmic vesicle;Cell membrane	NA	Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;G alpha (q) signalling events;P2Y receptors;Leukotriene receptors	PE1	2
+NX_Q13308	Inactive tyrosine-protein kinase 7	1070	118392	6.67	1	Membrane;Cell junction	NA	Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.	MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	NA	PE1	6
+NX_Q13309	S-phase kinase-associated protein 2	424	47761	6.67	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.;Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.	Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13.;Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3.	NA	Protein modification; protein ubiquitination.;Cell cycle;Ubiquitin mediated proteolysis;Herpes simplex infection;Pathways in cancer;Small cell lung cancer;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Orc1 removal from chromatin;Antigen processing: Ubiquitination &amp; Proteasome degradation;SCF(Skp2)-mediated degradation of p27/p21;Cyclin D associated events in G1;Ub-specific processing proteases;Neddylation;Regulation of RUNX2 expression and activity	PE1	5
+NX_Q13310	Polyadenylate-binding protein 4	644	70783	9.31	0	Cytoplasm;Cytosol	NA	Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).	Arg-518 is dimethylated, probably to asymmetric dimethylarginine.	Belongs to the polyadenylate-binding protein type-1 family.	RNA transport;mRNA surveillance pathway;RNA degradation	PE1	1
+NX_Q13315	Serine-protein kinase ATM	3056	350687	6.39	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	Ataxia telangiectasia	Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C (PubMed:9843217, PubMed:9733515, PubMed:10550055, PubMed:10766245, PubMed:10839545, PubMed:10910365, PubMed:10802669, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:30612738). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878).	Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent autophosphorylation on Ser-1981. Acetylated in vitro by KAT5/TIP60.;Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA damage-mediated activation of the kinase.;ATM is phosphorylated by NUAK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the PI3/PI4-kinase family. ATM subfamily.	Cell cycle;p53 signaling pathway;Apoptosis;HTLV-I infection;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of HSF1-mediated heat shock response;DNA Damage/Telomere Stress Induced Senescence;Meiotic recombination;G2/M DNA damage checkpoint;Stabilization of p53;Sensing of DNA Double Strand Breaks;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Nonhomologous End-Joining (NHEJ);TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;TP53 Regulates Transcription of Caspase Activators and Caspases	PE1	11
+NX_Q13316	Dentin matrix acidic phosphoprotein 1	513	55782	4	0	Cytoplasm;Extracellular matrix;Nucleus	Hypophosphatemic rickets, autosomal recessive, 1	May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.	Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif.	NA	ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	4
+NX_Q13319	Cyclin-dependent kinase 5 activator 2	367	38705	9.76	0	Cell membrane	NA	Activator of CDK5/TPKII.	Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39).	Belongs to the cyclin-dependent kinase 5 activator family.	NA	PE1	2
+NX_Q13322	Growth factor receptor-bound protein 10	594	67231	8.06	0	Cytoplasm;Cytoplasmic vesicle	NA	Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.	Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation (By similarity). Phosphorylated at Tyr-67 by TEC.;GRB10 is phosphorylated by RET (Phosphotyrosine:PTM-0255)	Belongs to the GRB7/10/14 family.	Signaling by SCF-KIT;IRS activation;Signal attenuation;Insulin receptor signalling cascade;RET signaling	PE1	7
+NX_Q13323	Bcl-2-interacting killer	160	18016	4.21	1	Mitochondrion membrane;Endomembrane system	NA	Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.	Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.	NA	NA	PE1	22
+NX_Q13324	Corticotropin-releasing factor receptor 2	411	47688	7.87	7	Cell membrane	NA	G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.	A N-glycosylation site within the signal peptide impedes its proper cleavage and function.	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Class B/2 (Secretin family receptors);Synthesis, secretion, and deacylation of Ghrelin	PE1	7
+NX_Q13325	Interferon-induced protein with tetratricopeptide repeats 5	482	55847	7	0	Ruffle membrane;Cell membrane	NA	Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375).	NA	Belongs to the IFIT family.	NA	PE1	10
+NX_Q13326	Gamma-sarcoglycan	291	32379	5.64	1	Sarcolemma;Cytoskeleton	Muscular dystrophy, limb-girdle, autosomal recessive 5	Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.	NA	Belongs to the sarcoglycan beta/delta/gamma/zeta family.	Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Viral myocarditis	PE1	13
+NX_Q13330	Metastasis-associated protein MTA1	715	80786	9.34	0	Cytoplasm;Nucleoplasm;Nucleus envelope;Cytosol;Nucleus;Cytoskeleton	NA	Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression.;Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity).	Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER).;Acetylation is essential for its transcriptional coactivator activity.;Sumoylation positively regulates its transcriptional corepressor activity but does not affect the protein stability. Sumoylated preferentially by SUMO2 or SUMO3 than SUMO1. Sumoylation is enhanced by PIAS1/3/4 and preferentially sumoylated by SUMO2 in the presence of PIAS1/3/4. Desumoylated by SENP1.;Ubiquitinated by COP1, which leads to proteasomal degradation.;MTA1 is phosphorylated by CSNK1G2	NA	RNA Polymerase I Transcription Initiation;HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;SUMOylation of transcription factors;Regulation of PTEN gene transcription	PE1	14
+NX_Q13332	Receptor-type tyrosine-protein phosphatase S	1948	217041	6.06	1	Cell membrane;Synaptosome;Growth cone;Perikaryon;Synaptic vesicle membrane;Postsynaptic density;Cytosol;Neuron projection;Axon	NA	Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).	A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).	Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.	ECM proteoglycans;Synaptic adhesion-like molecules;Receptor-type tyrosine-protein phosphatases;Signaling by NTRK3 (TRKC)	PE1	19
+NX_Q13336	Urea transporter 1	389	42528	6.79	8	Basolateral cell membrane;Cell membrane	NA	Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.	NA	Belongs to the urea transporter family.	Transport of bile salts and organic acids, metal ions and amine compounds	PE1	18
+NX_Q13342	Nuclear body protein SP140	867	98223	5.21	0	Cytoplasm;Mitochondrion;Nucleolus;PML body;Nucleus	NA	Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382).	Phosphorylation at Thr-726 promotes binding of PIN1 and subsequent isomerization of Pro-727.	NA	NA	PE1	2
+NX_Q13347	Eukaryotic translation initiation factor 3 subunit I	325	36502	5.38	0	Cytoplasm;Cytosol	NA	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).	Phosphorylated by TGF-beta type II receptor.	Belongs to the eIF-3 subunit I family.	RNA transport;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	1
+NX_Q13349	Integrin alpha-D	1161	126758	5.5	1	Membrane	NA	Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.	NA	Belongs to the integrin alpha chain family.	Regulation of actin cytoskeleton;Integrin cell surface interactions	PE1	16
+NX_Q13351	Krueppel-like factor 1	362	38221	6.67	0	Nucleoplasm;Nucleus	Anemia, congenital dyserythropoietic, 4	Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.	Sumoylated; sumoylation, promoted by PIAS1, leads to repression of megakaryocyte differentiation. Also promotes the interaction with the CDH4 subunit of the NuRD repression complex (By similarity).;Phosphorylated primarily on serine residues in the transactivation domain. Phosphorylation on Thr-23 is critical for the transactivation activity (By similarity).;Acetylated; can be acetylated on both Lys-274 and Lys-288. Acetylation on Lys-274 (by CBP) appears to be the major site affecting EKLF transactivation activity (By similarity).	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q13352	Centromere protein R	177	20194	9.13	0	Kinetochore;Cytoplasm;Nucleoplasm;Centromere;Nucleus	NA	Transcription coregulator that can have both coactivator and corepressor functions.;But not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.	NA	NA	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;NRIF signals cell death from the nucleus;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	1
+NX_Q13356	RING-type E3 ubiquitin-protein ligase PPIL2	520	58823	8.92	0	Nucleoplasm;Nucleus	NA	Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).	NA	Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Basigin interactions	PE1	22
+NX_Q13360	Zinc finger protein 177	481	54782	8.53	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q13361	Microfibrillar-associated protein 5	173	19612	5.64	0	Extracellular matrix	Aortic aneurysm, familial thoracic 9	May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (PubMed:8557636).	Forms intermolecular disulfide bonds either with other MAGP-2 molecules or with other components of the microfibrils.;N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycan heterogeneity at Thr-54: HexHexNAc (major) and HexHexNAc + sulfate (minor).	Belongs to the MFAP family.	Molecules associated with elastic fibres;Elastic fibre formation	PE1	12
+NX_Q13362	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	524	61061	6.41	0	Golgi apparatus;Nucleoplasm;Centromere;Cytosol;Nucleus	NA	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.	Is phosphorylated on serine residues.;Phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.	Belongs to the phosphatase 2A regulatory subunit B56 family.	mRNA surveillance pathway;Oocyte meiosis;Wnt signaling pathway;Dopaminergic synapse;Degradation of beta-catenin by the destruction complex;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Negative regulation of MAPK pathway;RAF activation;Disassembly of the destruction complex and recruitment of AXIN to the membrane;CTLA4 inhibitory signaling;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Platelet sensitization by LDL;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Regulation of TP53 Degradation	PE1	14
+NX_Q13363	C-terminal-binding protein 1	440	47535	6.28	0	Nucleoplasm;Cytoplasm;Nucleus	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.	ADP-ribosylated; when cells are exposed to brefeldin A.;Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.;The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Wnt signaling pathway;Notch signaling pathway;Pathways in cancer;Chronic myeloid leukemia;Deactivation of the beta-catenin transactivating complex;Repression of WNT target genes;TCF7L2 mutants don't bind CTBP;SUMOylation of transcription cofactors	PE1	4
+NX_Q13367	AP-3 complex subunit beta-2	1082	119059	5.43	0	Nucleoplasm;Golgi apparatus;Cytosol;Clathrin-coated vesicle membrane	Epileptic encephalopathy, early infantile, 48	Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.	NA	Belongs to the adaptor complexes large subunit family.	Lysosome	PE1	15
+NX_Q13368	MAGUK p55 subfamily member 3	585	66152	6.34	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the MAGUK family.	NA	PE1	17
+NX_Q13370	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	1112	124333	5.61	6	Membrane;Endoplasmic reticulum	NA	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.	Purine metabolism;Insulin signaling pathway;Progesterone-mediated oocyte maturation;G alpha (s) signalling events;PDE3B signalling	PE1	11
+NX_Q13371	Phosducin-like protein	301	34282	4.65	0	Cytoplasm;Nucleoplasm;Cilium;Cytosol	NA	Acts as a positive regulator of hedgehog signaling and regulates ciliary function.;Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.;Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.	NA	Belongs to the phosducin family.	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	9
+NX_Q13387	C-Jun-amino-terminal kinase-interacting protein 2	824	87975	4.36	0	Cytoplasm	NA	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).	NA	Belongs to the JIP scaffold family.	MAPK signaling pathway	PE1	22
+NX_Q13393	Phospholipase D1	1074	124184	8.91	0	Endoplasmic reticulum membrane;Perinuclear region;Late endosome membrane;Golgi apparatus membrane	Cardiac valvular defect, developmental	Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).	NA	Belongs to the phospholipase D family.	Glycerophospholipid metabolism;Ether lipid metabolism;Metabolic pathways;Endocytosis;Fc gamma R-mediated phagocytosis;Glutamatergic synapse;GnRH signaling pathway;Pathways in cancer;Pancreatic cancer;Synthesis of PA;Role of phospholipids in phagocytosis;Synthesis of PG;Neutrophil degranulation	PE1	3
+NX_Q13394	Putative nucleotidyltransferase MAB21L1	359	40956	8.94	0	Nucleus	NA	Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is unclear whether it displays nucleotidyltransferase activity in vivo (PubMed:27271801). Binds single-stranded RNA (ssRNA) (PubMed:27271801).	NA	Belongs to the mab-21 family.	NA	PE1	13
+NX_Q13395	Probable methyltransferase TARBP1	1621	181675	6.66	0	Nucleus speckle	NA	Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs.;(Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II (PubMed:7638159, PubMed:8626763, PubMed:8846792). Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA (PubMed:7638159, PubMed:8626763, PubMed:8846792).	NA	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.	NA	PE1	1
+NX_Q13398	Zinc finger protein 211	564	64535	8.83	0	Cytoplasm;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q13401	Putative postmeiotic segregation increased 2-like protein 3	168	18716	4.52	0	NA	NA	NA	NA	Belongs to the DNA mismatch repair MutL/HexB family.	NA	PE5	7
+NX_Q13402	Unconventional myosin-VIIa	2215	254390	8.79	0	Cytoplasm;Cytosol;Cell cortex;Cytoskeleton	Usher syndrome 1B;Deafness, autosomal dominant, 11;Deafness, autosomal recessive, 2	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	The canonical retinoid cycle in rods (twilight vision)	PE1	11
+NX_Q13404	Ubiquitin-conjugating enzyme E2 variant 1	147	16495	7.71	0	Nucleus	NA	Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.	NA	Belongs to the ubiquitin-conjugating enzyme family.	FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IKK complex recruitment mediated by RIP1;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;TICAM1, RIP1-mediated IKK complex recruitment;Interleukin-1 signaling	PE1	20
+NX_Q13405	39S ribosomal protein L49, mitochondrial	166	19198	9.47	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL49 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	11
+NX_Q13409	Cytoplasmic dynein 1 intermediate chain 2	638	71457	5.08	0	Cytoplasm;Nucleolus;Endoplasmic reticulum;Cytosol;Nucleus;Cytoskeleton	NA	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.	The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding.	Belongs to the dynein intermediate chain family.	Phagosome;Vasopressin-regulated water reabsorption;Salmonella infection;Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Recruitment of NuMA to mitotic centrosomes;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;AURKA Activation by TPX2;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	2
+NX_Q13410	Butyrophilin subfamily 1 member A1	526	58960	5.38	1	Membrane;Secreted	NA	May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).	N-glycosylated.	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Butyrophilin (BTN) family interactions	PE1	6
+NX_Q13415	Origin recognition complex subunit 1	861	97350	9.34	0	Nucleoplasm;Nucleus	Meier-Gorlin syndrome 1	Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Phosphorylated during mitosis.	Belongs to the ORC1 family.	Cell cycle;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;Activation of ATR in response to replication stress;CDC6 association with the ORC:origin complex;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;G1/S-Specific Transcription;E2F-enabled inhibition of pre-replication complex formation;Assembly of the ORC complex at the origin of replication	PE1	1
+NX_Q13416	Origin recognition complex subunit 2	577	65972	6.07	0	Nucleoplasm;Cytosol;Nucleus	NA	Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.	NA	Belongs to the ORC2 family.	Cell cycle;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;Activation of ATR in response to replication stress;CDC6 association with the ORC:origin complex;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;E2F-enabled inhibition of pre-replication complex formation;Assembly of the ORC complex at the origin of replication	PE1	2
+NX_Q13418	Integrin-linked protein kinase	452	51419	8.3	0	Cell membrane;Cell junction;Focal adhesion;Sarcomere;Nucleoplasm;Lamellipodium	NA	Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).	Autophosphorylated on serine residues.	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	PPAR signaling pathway;Focal adhesion;Bacterial invasion of epithelial cells;Endometrial cancer;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;Cell-extracellular matrix interactions	PE1	11
+NX_Q13421	Mesothelin	630	68986	6.03	0	Golgi apparatus;Cell membrane;Secreted;Nucleoplasm;Cytoplasmic vesicle	NA	Membrane-anchored forms may play a role in cellular adhesion.;Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.	Both MPF and the cleaved form of mesothelin are N-glycosylated.;Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.	Belongs to the mesothelin family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational modification: synthesis of GPI-anchored proteins;Post-translational protein phosphorylation	PE1	16
+NX_Q13422	DNA-binding protein Ikaros	519	57528	6.12	0	Cytoplasm;Nucleus	Immunodeficiency, common variable, 13	Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).	Sumoylated. Simulataneous sumoylation on the 2 sites results in a loss of both HDAC-dependent and HDAC-independent repression. Has no effect on pericentromeric heterochromatin location. Desumoylated by SENP1 (By similarity).;Phosphorylation controls cell-cycle progression from late G(1) stage to S stage. Hyperphosphorylated during G2/M phase. Dephosphorylated state during late G(1) phase. Phosphorylation on Thr-140 is required for DNA and pericentromeric location during mitosis. CK2 is the main kinase, in vitro. GSK3 and CDK may also contribute to phosphorylation of the C-terminal serine and threonine residues. Phosphorylation on these C-terminal residues reduces the DNA-binding ability. Phosphorylation/dephosphorylation events on Ser-13 and Ser-295 regulate TDT expression during thymocyte differentiation. Dephosphorylation by protein phosphatase 1 regulates stability and pericentromeric heterochromatin location. Phosphorylated in both lymphoid and non-lymphoid tissues (By similarity). Phosphorylation at Ser-361 and Ser-364 downstream of SYK induces nuclear translocation.;Polyubiquitinated.	Belongs to the Ikaros C2H2-type zinc-finger protein family.	NOTCH3 Intracellular Domain Regulates Transcription	PE1	7
+NX_Q13423	NAD(P) transhydrogenase, mitochondrial	1086	113896	8.31	14	Mitochondrion inner membrane;Mitochondrion	Glucocorticoid deficiency 4 with or without mineralocorticoid deficiency	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (PubMed:22634753).	NA	In the N-terminal section; belongs to the AlaDH/PNT family.;In the C-terminal section; belongs to the PNT beta subunit family.	Nicotinate and nicotinamide metabolism;Metabolic pathways;Citric acid cycle (TCA cycle)	PE1	5
+NX_Q13424	Alpha-1-syntrophin	505	53895	6.35	0	Cell junction;Sarcolemma;Cytoskeleton	Long QT syndrome 12	Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).	Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).	Belongs to the syntrophin family.	NA	PE1	20
+NX_Q13425	Beta-2-syntrophin	540	57950	9.03	0	Membrane;Cell junction;Secretory vesicle membrane;Cytoskeleton	NA	Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.	Phosphorylated. Partially dephosphorylated upon insulin stimulation.	Belongs to the syntrophin family.	NA	PE1	16
+NX_Q13426	DNA repair protein XRCC4	336	38287	4.91	0	Nucleoplasm;Nucleus	Short stature, microcephaly, and endocrine dysfunction	Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.	Monoubiquitinated.;Phosphorylated by PRKDC. The phosphorylation seems not to be necessary for binding to DNA. Phosphorylation by CK2 promotes interaction with APTX.;Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. Has no effect on ubiquitination.	Belongs to the XRCC4 family.	Non-homologous end-joining;SUMOylation of DNA damage response and repair proteins;2-LTR circle formation;Nonhomologous End-Joining (NHEJ)	PE1	5
+NX_Q13427	Peptidyl-prolyl cis-trans isomerase G	754	88617	10.29	0	Nucleus matrix;Nucleus speckle;Nucleus;Cytosol	NA	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.	NA	NA	NA	PE1	2
+NX_Q13428	Treacle protein	1488	152106	9.06	0	Nucleolus	Treacher Collins syndrome 1	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).	Ubiquitinated. Monoubiquitination by the BCR(KBTBD8) complex promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).	NA	Ribosome biogenesis in eukaryotes	PE1	5
+NX_Q13432	Protein unc-119 homolog A	240	26962	6	0	Spindle pole;Spindle;Centrosome	Immunodeficiency 13	Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A.	NA	Belongs to the PDE6D/unc-119 family.	NA	PE1	17
+NX_Q13433	Zinc transporter ZIP6	755	85047	6.45	6	Nucleoplasm;Cytosol;Cell membrane	NA	May act as a zinc-influx transporter.	N-glycosylated.	Belongs to the ZIP transporter (TC 2.A.5) family.	Zinc influx into cells by the SLC39 gene family	PE1	18
+NX_Q13434	Putative E3 ubiquitin-protein ligase makorin-4	485	52910	5.08	0	NA	NA	May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	NA	NA	Protein modification; protein ubiquitination.	PE5	X
+NX_Q13435	Splicing factor 3B subunit 2	895	100228	5.52	0	Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).	Methylation at Arg-508 by PRMT9 is required for the interaction with SMN1.	NA	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	11
+NX_Q13438	Protein OS-9	667	75562	4.8	0	Endoplasmic reticulum;Endoplasmic reticulum lumen	NA	Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.	Intramolecular disulfide bonds.;Are N-glycosylated.	Belongs to the OS-9 family.	Protein processing in endoplasmic reticulum;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;ER Quality Control Compartment (ERQC);ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis	PE1	12
+NX_Q13439	Golgin subfamily A member 4	2230	261140	5.33	0	Golgi apparatus;Cytoplasm;trans-Golgi network membrane;Nucleoplasm;Golgi apparatus membrane	NA	Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197).	NA	NA	Retrograde transport at the Trans-Golgi-Network	PE1	3
+NX_Q13442	28 kDa heat- and acid-stable phosphoprotein	181	20630	8.84	0	Cytosol;Cell membrane	NA	Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.	NA	Belongs to the PDAP1 family.	Neutrophil degranulation	PE1	7
+NX_Q13443	Disintegrin and metalloproteinase domain-containing protein 9	819	90556	7.71	1	Endoplasmic reticulum;Cytoplasmic vesicle;Secreted;Cell membrane	Cone-rod dystrophy 9	May act as alpha-secretase for amyloid precursor protein (APP).;Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.	Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).;Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9.	NA	Collagen degradation	PE1	8
+NX_Q13444	Disintegrin and metalloproteinase domain-containing protein 15	863	92959	6.3	1	Endomembrane system;Adherens junction;Flagellum;Cytoplasmic vesicle;Acrosome	NA	Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.	Phosphorylation increases association with PTKs.;The precursor is cleaved by a furin endopeptidase.	NA	Degradation of the extracellular matrix;Invadopodia formation	PE1	1
+NX_Q13445	Transmembrane emp24 domain-containing protein 1	227	25206	4.39	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;cis-Golgi network membrane;Endoplasmic reticulum membrane;Cell membrane	NA	Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.	NA	Belongs to the EMP24/GP25L family.	NA	PE1	19
+NX_Q13449	Limbic system-associated membrane protein	338	37393	6.55	0	Cytosol;Cell membrane	NA	Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity).	NA	Belongs to the immunoglobulin superfamily. IgLON family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	3
+NX_Q13451	Peptidyl-prolyl cis-trans isomerase FKBP5	457	51212	5.71	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.	NA	NA	HSP90 chaperone cycle for steroid hormone receptors (SHR);ESR-mediated signaling;MECP2 regulates neuronal receptors and channels	PE1	6
+NX_Q13454	Tumor suppressor candidate 3	348	39676	9.93	4	Endoplasmic reticulum membrane	Mental retardation, autosomal recessive 7	Magnesium transporter.;Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.	NA	Belongs to the OST3/OST6 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;Miscellaneous transport and binding events;Asparagine N-linked glycosylation	PE1	8
+NX_Q13459	Unconventional myosin-IXb	2157	243401	8.91	0	Cytosol;Cell cortex;Perinuclear region;Cytoskeleton	Celiac disease 4	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Regulation of actin dynamics for phagocytic cup formation;Rho GTPase cycle;SLIT2:ROBO1 increases RHOA activity	PE1	19
+NX_Q13461	Forkhead box protein E3	319	33234	9.72	0	Nucleus	Anterior segment dysgenesis 2;Aortic aneurysm, familial thoracic 11;Cataract 34, multiple types	Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed:27218149).	NA	NA	NA	PE1	1
+NX_Q13464	Rho-associated protein kinase 1	1354	158175	5.66	0	Cytoplasm;Cell membrane;Bleb;Centriole;Lamellipodium;Golgi apparatus membrane;Ruffle;Cytoskeleton	NA	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.	Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.;Autophosphorylated on serine and threonine residues.;Autophosphorylated (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Chemokine signaling pathway;Vascular smooth muscle contraction;Wnt signaling pathway;TGF-beta signaling pathway;Axon guidance;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;EPHB-mediated forward signaling;G alpha (12/13) signalling events;VEGFA-VEGFR2 Pathway;EPHA-mediated growth cone collapse;Apoptotic cleavage of cellular proteins;Sema4D induced cell migration and growth-cone collapse;RHO GTPases Activate ROCKs;Neutrophil degranulation	PE1	18
+NX_Q13467	Frizzled-5	585	64507	8.69	7	Cell membrane;Perikaryon;Synapse;Golgi apparatus membrane;Axon;Dendrite	NA	Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).	Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.	Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Asymmetric localization of PCP proteins;Class B/2 (Secretin family receptors);Ca2+ pathway;Regulation of FZD by ubiquitination;RNF mutants show enhanced WNT signaling and proliferation;Disassembly of the destruction complex and recruitment of AXIN to the membrane;WNT5A-dependent internalization of FZD2, FZD5 and ROR2	PE1	2
+NX_Q13469	Nuclear factor of activated T-cells, cytoplasmic 2	925	100146	6.87	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.	Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome.;In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, all these sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 or Ser-56 is phosphorylated; which is required for full transcriptional activity.	NA	MAPK signaling pathway;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Osteoclast differentiation;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;HTLV-I infection;FCERI mediated Ca+2 mobilization;CLEC7A (Dectin-1) induces NFAT activation;Calcineurin activates NFAT;RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	PE1	20
+NX_Q13470	Non-receptor tyrosine-protein kinase TNK1	666	72468	9.57	0	Membrane;Cytoplasm;Cell junction	NA	Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.	Autophosphorylated on tyrosine residues.	Belongs to the protein kinase superfamily. Tyr protein kinase family.	NA	PE1	17
+NX_Q13472	DNA topoisomerase 3-alpha	1001	112372	8.69	0	Mitochondrion matrix	Microcephaly, growth restriction, and increased sister chromatid exchange 2;Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 5	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity (PubMed:30057030). It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2 (PubMed:29290614).	NA	Belongs to the type IA topoisomerase family.	Homologous recombination;Fanconi anemia pathway;Meiotic recombination;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	17
+NX_Q13474	Dystrophin-related protein 2	957	107962	5.82	0	Nucleus speckle;Cell membrane;Perikaryon;Postsynaptic density;Dendrite	NA	Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.	NA	NA	NA	PE1	X
+NX_Q13477	Mucosal addressin cell adhesion molecule 1	382	40155	5	1	Membrane	NA	Lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.;Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.	The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.	NA	Cell adhesion molecules (CAMs);Intestinal immune network for IgA production;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions	PE1	19
+NX_Q13478	Interleukin-18 receptor 1	541	62304	8.06	1	Membrane;Mitochondrion	NA	Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).	N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.	Belongs to the interleukin-1 receptor family.	Cytokine-cytokine receptor interaction;Interleukin-18 signaling;Interleukin-37 signaling	PE1	2
+NX_Q13480	GRB2-associated-binding protein 1	694	76616	5.63	0	Cytosol;Nucleolus;Cell membrane	Deafness, autosomal recessive, 26	Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).	Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.;GAB1 is phosphorylated by HCK;GAB1 is phosphorylated by SRC (Phosphotyrosine:PTM-0255);GAB1 is phosphorylated by MST1R (Phosphotyrosine:PTM-0255)	Belongs to the GAB family.	ErbB signaling pathway;Neurotrophin signaling pathway;Bacterial invasion of epithelial cells;Renal cell carcinoma;PI3K Cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;PI3K events in ERBB2 signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;GAB1 signalosome;Constitutive Signaling by EGFRvIII;Signaling by FGFR4 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR3 fusions in cancer;RET signaling;MET activates RAP1 and RAC1;MET activates PI3K/AKT signaling;MET activates PTPN11;MET receptor recycling;Activated NTRK2 signals through PI3K;Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	PE1	4
+NX_Q13485	Mothers against decapentaplegic homolog 4	552	60439	6.5	0	Cytoplasm;Nucleoplasm;Centrosome;Cytosol;Nucleus	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome;Pancreatic cancer;Myhre syndrome;Juvenile polyposis syndrome;Colorectal cancer	In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.	Monoubiquitinated on Lys-519 by E3 ubiquitin-protein ligase TRIM33. Monoubiquitination hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination by USP9X restores its competence to mediate TGF-beta signaling.;Phosphorylated by PDPK1.;SMAD4 is phosphorylated by PDPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the dwarfin/SMAD family.	Cell cycle;Wnt signaling pathway;TGF-beta signaling pathway;Adherens junction;HTLV-I infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Chronic myeloid leukemia;Transcriptional regulation of pluripotent stem cells;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Signaling by BMP;TGF-beta receptor signaling activates SMADs;Signaling by NODAL;Signaling by Activin;SMAD4 MH2 Domain Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;Ub-specific processing proteases;RUNX3 regulates CDKN1A transcription;RUNX3 regulates BCL2L11 (BIM) transcription;RUNX2 regulates bone development;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell cycle genes	PE1	18
+NX_Q13487	snRNA-activating protein complex subunit 2	334	35556	5.79	0	Nucleoplasm;Cytosol;Nucleus	NA	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.	NA	NA	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA polymerase II transcribes snRNA genes	PE1	19
+NX_Q13488	V-type proton ATPase 116 kDa subunit a isoform 3	830	92968	6.66	8	Membrane;Mitochondrion	Osteopetrosis, autosomal recessive 1	Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation.	NA	Belongs to the V-ATPase 116 kDa subunit family.	Oxidative phosphorylation;Metabolic pathways;Lysosome;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Tuberculosis;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport;Neutrophil degranulation	PE1	11
+NX_Q13489	Baculoviral IAP repeat-containing protein 3	604	68372	5.71	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.	Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.	Belongs to the IAP family.	Ubiquitin mediated proteolysis;Apoptosis;Focal adhesion;NOD-like receptor signaling pathway;Toxoplasmosis;HTLV-I infection;Pathways in cancer;Small cell lung cancer;TNFR2 non-canonical NF-kB pathway;NOD1/2 Signaling Pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;IKK complex recruitment mediated by RIP1;RIPK1-mediated regulated necrosis;Regulation of necroptotic cell death;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases;TICAM1, RIP1-mediated IKK complex recruitment	PE1	11
+NX_Q13490	Baculoviral IAP repeat-containing protein 2	618	69900	6.27	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.	Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.	Belongs to the IAP family.	Ubiquitin mediated proteolysis;Apoptosis;Focal adhesion;NOD-like receptor signaling pathway;Toxoplasmosis;HTLV-I infection;Pathways in cancer;Small cell lung cancer;TNFR2 non-canonical NF-kB pathway;NOD1/2 Signaling Pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;Apoptotic cleavage of cellular proteins;IKK complex recruitment mediated by RIP1;RIPK1-mediated regulated necrosis;Regulation of necroptotic cell death;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases;TICAM1, RIP1-mediated IKK complex recruitment	PE1	11
+NX_Q13491	Neuronal membrane glycoprotein M6-b	265	28989	5.53	4	Cell membrane	NA	May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.	NA	Belongs to the myelin proteolipid protein family.	NA	PE1	X
+NX_Q13492	Phosphatidylinositol-binding clathrin assembly protein	652	70755	7.7	0	Golgi apparatus;Clathrin-coated vesicle;Cell membrane;Clathrin-coated pit;Cytoplasmic vesicle;Nucleus	NA	Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654).	NA	Belongs to the PICALM/SNAP91 family.	Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	11
+NX_Q13495	Mastermind-like domain-containing protein 1	774	83231	8.54	0	Nucleoplasm;Nucleus	Hypospadias 2, X-linked	Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ.	NA	Belongs to the mastermind family.	Pre-NOTCH Transcription and Translation;Notch-HLH transcription pathway;NOTCH2 intracellular domain regulates transcription;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE1	X
+NX_Q13496	Myotubularin	603	69932	8.38	0	Cytoplasm;Cell membrane;Sarcomere;Filopodium;Late endosome;Ruffle	Myopathy, centronuclear, X-linked	Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:11001925, PubMed:10900271, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane	PE1	X
+NX_Q13501	Sequestosome-1	440	47687	5.1	0	Sarcomere;Endoplasmic reticulum;Autophagosome;PML body;Late endosome;Cytoplasmic vesicle;Cytosol;Lysosome;Nucleus	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3;Paget disease of bone 3;Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset;Myopathy, distal, with rimmed vacuoles	Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Promotes relocalization of 'Lys-63'-linked ubiquitinated TMEM173/STING to autophagosomes (PubMed:29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357).	Phosphorylated. May be phosphorylated by PRKCZ (By similarity). Phosphorylated in vitro by TTN (PubMed:15802564). Phosphorylation at Ser-403 by ULK1 is stimulated by SESN2 (PubMed:25040165). Phosphorylated at Ser-403 by TBK1, leading to promote relocalization of 'Lys-63'-linked ubiquitinated TMEM173/STING to autophagosomes (PubMed:29496741). Phosphorylation at Ser-349 by MTOR promotes interaction with KEAP1 and inactivation of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (By similarity).;Ubiquitinated by RNF26: ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Deubiquitination by USP15 releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Ubiquitinated by the BCR(KEAP1) complex at Lys-420, increasing SQSTM1 sequestering activity and promoting its degradation (PubMed:28380357). Ubiquitinated via 'Lys-29' and 'Lys-33'-linked polyubiquitination leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896).;SQSTM1 is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Osteoclast differentiation;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;NRIF signals cell death from the nucleus;Pink/Parkin Mediated Mitophagy;Interleukin-1 signaling	PE1	5
+NX_Q13503	Mediator of RNA polymerase II transcription subunit 21	144	15564	4.29	0	Nucleoplasm;Nucleolus;Cytosol;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 21 family.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	12
+NX_Q13505	Metaxin-1	466	51463	9.8	1	Membrane;Mitochondrion;Mitochondrion outer membrane	NA	Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	Belongs to the metaxin family.	Mitochondrial protein import;Cristae formation	PE1	1
+NX_Q13506	NGFI-A-binding protein 1	487	54401	6.24	0	Golgi apparatus;Nucleoplasm;Nucleus;Cell membrane	NA	Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.	NA	Belongs to the NAB family.	NA	PE1	2
+NX_Q13507	Short transient receptor potential channel 3	836	96009	6.25	6	Membrane	Spinocerebellar ataxia 41	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.	TRPC3 is phosphorylated by PRKCG (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily.	TRP channels;Effects of PIP2 hydrolysis;Role of second messengers in netrin-1 signaling;Elevation of cytosolic Ca2+ levels;MECP2 regulates neuronal receptors and channels	PE1	4
+NX_Q13508	Ecto-ADP-ribosyltransferase 3	389	43923	5.71	0	Cell membrane	NA	NA	O-glycosylated with core 1 or possibly core 8 glycans.	Belongs to the Arg-specific ADP-ribosyltransferase family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	4
+NX_Q13509	Tubulin beta-3 chain	450	50433	4.83	0	Lamellipodium;Filopodium;Cytoskeleton	Cortical dysplasia, complex, with other brain malformations 1;Fibrosis of extraocular muscles, congenital, 3A	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977).	Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;TUBB3 is phosphorylated by GRK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	16
+NX_Q13510	Acid ceramidase	395	44660	7.52	0	Cytoplasm;Secreted;Nucleus;Lysosome	Farber lipogranulomatosis;Spinal muscular atrophy with progressive myoclonic epilepsy	May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity.;Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:10610716, PubMed:7744740, PubMed:15655246, PubMed:11451951). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:10610716). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (PubMed:7744740, PubMed:15655246). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:12764132, PubMed:12815059). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (PubMed:12764132). Has also an N-acylethanolamine hydrolase activity (PubMed:15655246). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (PubMed:17713573). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (PubMed:22261821).	N-glycosylated.;Proteolytically cleaved into two chains alpha and beta that remain associated via a disulfide bond (PubMed:7744740, PubMed:11451951, PubMed:30525581, PubMed:29692406). Cleavage gives rise to a conformation change that activates the enzyme. The same catalytic Cys residue mediates the autoproteolytic cleavage and subsequent hydrolysis of lipid substrates (PubMed:30525581, PubMed:29692406). The beta chain may undergo an additional C-terminal processing (PubMed:12815059).	Belongs to the acid ceramidase family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Lysosome;Glycosphingolipid metabolism;Neutrophil degranulation	PE1	8
+NX_Q13515	Phakinin	415	45880	5.41	0	Cytosol;Cell cortex;Cytoskeleton;Cell membrane	Cataract 12, multiple types	Involved in stabilization of lens fiber cell cytoskeleton.	NA	Belongs to the intermediate filament family.	NA	PE1	3
+NX_Q13516	Oligodendrocyte transcription factor 2	323	32385	9.28	0	Cytoplasm;Nucleoplasm;Nucleus;Cell membrane	NA	Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.	NA	NA	NA	PE1	21
+NX_Q13519	Prepronociceptin	176	20295	8.73	0	Secreted	NA	Orphanin FQ2: Has potent analgesic activity.;Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.;Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.	The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.;Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.	Belongs to the opioid neuropeptide precursor family.	G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	8
+NX_Q13520	Aquaporin-6	282	29370	8.88	6	Cytoplasmic vesicle membrane	NA	Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family.	Passive transport by Aquaporins	PE2	12
+NX_Q13522	Protein phosphatase 1 regulatory subunit 1A	171	19011	5.9	0	NA	NA	Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.	Phosphorylation of Thr-35 is required for activity.	Belongs to the protein phosphatase inhibitor 1 family.	Long-term potentiation	PE1	12
+NX_Q13523	Serine/threonine-protein kinase PRP4 homolog	1007	116987	10.26	0	Nucleus speckle;Nucleus	NA	Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.	Phosphorylated by Clk1.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.	NA	PE1	6
+NX_Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	163	18243	8.95	0	Cytoplasm;Nucleus speckle;Nucleoplasm;Cytosol;Nucleus	NA	Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, Ref. 21). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354).	Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its ability to induce centrosome amplification, chromosome instability and cell transformation.	NA	RIG-I-like receptor signaling pathway;ISG15 antiviral mechanism;Negative regulators of DDX58/IFIH1 signaling;RHO GTPases Activate NADPH Oxidases;Regulation of TP53 Activity through Phosphorylation;PI5P Regulates TP53 Acetylation	PE1	19
+NX_Q13530	Serine incorporator 3	473	52580	7.43	8	Perinuclear region;Cell membrane;Golgi apparatus membrane	NA	Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).	N-glycosylated.	Belongs to the TDE1 family.	Serine biosynthesis	PE1	20
+NX_Q13535	Serine/threonine-protein kinase ATR	2644	301367	7.17	0	Golgi apparatus;Chromosome;Nucleoplasm;PML body;Nucleus	Seckel syndrome 1;Cutaneous telangiectasia and cancer syndrome, familial	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.	Phosphorylated; autophosphorylates in vitro.	Belongs to the PI3/PI4-kinase family. ATM subfamily.	Fanconi anemia pathway;Cell cycle;p53 signaling pathway;HTLV-I infection;Regulation of HSF1-mediated heat shock response;Meiotic synapsis;Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation	PE1	3
+NX_Q13536	Protein CROC-4	156	17231	6.39	0	Nucleus	NA	May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes transcription of the FOS promoter.	NA	NA	NA	PE2	1
+NX_Q13541	Eukaryotic translation initiation factor 4E-binding protein 1	118	12580	5.32	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.	Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-37, Thr-46, Ser-65 and Thr-70) or associated with eIF4E.;Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.;EIF4EBP1 is phosphorylated by MAPK3	Belongs to the eIF4E-binding protein family.	RNA transport;ErbB signaling pathway;mTOR signaling pathway;Insulin signaling pathway;Acute myeloid leukemia;mTORC1-mediated signalling;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	PE1	8
+NX_Q13542	Eukaryotic translation initiation factor 4E-binding protein 2	120	12939	6.16	0	Nucleoplasm;Mitochondrion	NA	Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).	Phosphorylation at Thr-37, Thr-46, Ser-65, Thr-70 and Ser-83 is mediated by MTOR and corresponds to the hyperphosphorylated form: it abolishes binding to EIF4E by inducing folding of intrinsically disordered regions (PubMed:24207126, PubMed:25533957). First phosphorylated at Thr-37 and Thr-46 by MTOR, inducing folding of region encompassing residues from Pro-18 to Arg-62 of into a four-stranded beta-domain that sequesters the helical YXXXXLPhi motif into a partly buried beta-strand, blocking accessibility to EIF4E. Protein phosphorylated at Thr-37 and Thr-46 is however unstable and subsequent phosphorylation at Ser-65, Thr-70 and Ser-83 is required to stabilize the fold, decreasing affinity for EIF4E by a factor of 4000 (PubMed:24207126, PubMed:25533957). Phosphorylated in response to insulin, EGF and PDGF.;Deamidated at Asn-99 and Asn-102 to aspartate (Asp) in brain. Deamidation promotes interaction with RPTOR, subsequent phosphorylation by mTORC1 and increased translation, leading to impair kinetics of excitatory synaptic transmission. Deamidation takes place during postnatal development, when the PI3K-Akt-mTOR signaling is reduced, suggesting it acts as a compensatory mechanism to promote translation despite attenuated PI3K-Akt-mTOR signaling in neuron development. Deamidation converts Asn residues into a mixture of Asp and isoaspartate; interactions with PCMT1 is required to prevent isoaspartate accumulation and convert isoaspartate to Asp.	Belongs to the eIF4E-binding protein family.	NA	PE1	10
+NX_Q13546	Receptor-interacting serine/threonine-protein kinase 1	671	75931	5.92	0	Cytoplasm;Cytosol;Cell membrane	Immunodeficiency 57	Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules (PubMed:15258597). Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death (PubMed:15258597). RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (PubMed:19524513, PubMed:19524512).	Ubiquitinated by 'Lys-11'-, 'Lys-48'-, 'Lys-63'- and linear-linked type ubiquitin (PubMed:15258597, PubMed:16603398, PubMed:18450452, PubMed:21455173, PubMed:21931591, PubMed:29883609, Ref.33). Polyubiquitination with 'Lys-63'-linked chains by TRAF2 induces association with the IKK complex (PubMed:15258597). Deubiquitination of 'Lys-63'-linked chains and polyubiquitination with 'Lys-48'-linked chains by TNFAIP3 leads to RIPK1 proteasomal degradation and consequently down-regulates TNF-alpha-induced NFkappa-B signaling (PubMed:15258597). 'Lys-48'-linked polyubiquitination by RFFL or RNF34 also promotes proteasomal degradation and negatively regulates TNF-alpha-induced NF-kappa-B signaling (PubMed:18450452, Ref.33). Linear polyubiquitinated; the head-to-tail linear polyubiquitination ('Met-1'-linked) is mediated by the LUBAC complex and decreases protein kinase activity (PubMed:21455173). Deubiquitination of linear polyubiquitin by CYLD promotes the kinase activity (By similarity). Also ubiquitinated with 'Lys-11'-linked chains (PubMed:21455173). Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B (PubMed:21931591). Ubiquitinated with 'Lys-63'-linked chains by PELI1 (PubMed:29883609).;RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:18408713, PubMed:19524513). Phosphorylation of Ser-161 by RIPK3 is necessary for the formation of the necroptosis-inducing complex (PubMed:18408713).;Proteolytically cleaved by caspase-8 during TNF-induced apoptosis (PubMed:10521396). Cleavage abolishes NF-kappa-B activation and enhances pro-apoptotic signaling through the TRADD-FADD interaction (PubMed:10521396).	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	Apoptosis;Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Hepatitis C;TRP channels;RIP-mediated NFkB activation via ZBP1;TNFR1-induced proapoptotic signaling;Caspase activation via Death Receptors in the presence of ligand;TRIF-mediated programmed cell death;IKK complex recruitment mediated by RIP1;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TNF signaling;Regulation of necroptotic cell death;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases;Ovarian tumor domain proteases;TICAM1, RIP1-mediated IKK complex recruitment;TLR3-mediated TICAM1-dependent programmed cell death	PE1	6
+NX_Q13547	Histone deacetylase 1	482	55103	5.31	0	Nucleoplasm;Nucleus	NA	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.	Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by KCTD11, leading to proteasomal degradation.;Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5.;Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.	Belongs to the histone deacetylase family. HD type 1 subfamily.	Cell cycle;Notch signaling pathway;Huntington's disease;Pathways in cancer;Chronic myeloid leukemia;Factors involved in megakaryocyte development and platelet production;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Formation of the beta-catenin:TCF transactivating complex;HDACs deacetylate histones;G0 and Early G1;G1/S-Specific Transcription;Notch-HLH transcription pathway;Deactivation of the beta-catenin transactivating complex;Repression of WNT target genes;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;p75NTR negatively regulates cell cycle via SC1;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;SUMOylation of chromatin organization proteins;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of PTEN gene transcription;Estrogen-dependent gene expression;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;MECP2 regulates transcription of neuronal ligands;Loss of MECP2 binding ability to 5mC-DNA;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	1
+NX_Q13554	Calcium/calmodulin-dependent protein kinase type II subunit beta	666	72678	6.87	0	Cytoskeleton;Centrosome;Synapse;Sarcoplasmic reticulum membrane	Mental retardation, autosomal dominant 54	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.	Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	ErbB signaling pathway;Calcium signaling pathway;Oocyte meiosis;Wnt signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Olfactory transduction;GnRH signaling pathway;Melanogenesis;Gastric acid secretion;Tuberculosis;Glioma;RAF/MAP kinase cascade;Ion transport by P-type ATPases;Interferon gamma signaling;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Ras activation upon Ca2+ influx through NMDA receptor;HSF1-dependent transactivation;RAF activation;Trafficking of AMPA receptors;CaMK IV-mediated phosphorylation of CREB;Phase 0 - rapid depolarisation;Ion homeostasis;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Regulation of MECP2 expression and activity;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	7
+NX_Q13555	Calcium/calmodulin-dependent protein kinase type II subunit gamma	558	62607	7.9	0	Sarcoplasmic reticulum membrane	NA	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.	Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	ErbB signaling pathway;Calcium signaling pathway;Oocyte meiosis;Wnt signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Olfactory transduction;GnRH signaling pathway;Melanogenesis;Gastric acid secretion;Tuberculosis;Glioma;RAF/MAP kinase cascade;Ion transport by P-type ATPases;Interferon gamma signaling;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Ras activation upon Ca2+ influx through NMDA receptor;HSF1-dependent transactivation;RAF activation;Trafficking of AMPA receptors;CaMK IV-mediated phosphorylation of CREB;Phase 0 - rapid depolarisation;Ion homeostasis;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Regulation of MECP2 expression and activity;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	10
+NX_Q13557	Calcium/calmodulin-dependent protein kinase type II subunit delta	499	56369	6.81	0	Sarcolemma;Sarcoplasmic reticulum membrane	NA	Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.	Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	ErbB signaling pathway;Calcium signaling pathway;Oocyte meiosis;Wnt signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Olfactory transduction;GnRH signaling pathway;Melanogenesis;Gastric acid secretion;Tuberculosis;Glioma;RAF/MAP kinase cascade;Ion transport by P-type ATPases;Interferon gamma signaling;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;HSF1-dependent transactivation;RAF activation;Trafficking of AMPA receptors;CaMK IV-mediated phosphorylation of CREB;Phase 0 - rapid depolarisation;Ion homeostasis;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Regulation of MECP2 expression and activity;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	4
+NX_Q13561	Dynactin subunit 2	401	44231	5.1	0	Membrane;Endosome;Centrosome	NA	Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.	NA	Belongs to the dynactin subunit 2 family.	Vasopressin-regulated water reabsorption;Huntington's disease;Anchoring of the basal body to the plasma membrane;MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;AURKA Activation by TPX2;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	12
+NX_Q13562	Neurogenic differentiation factor 1	356	39920	5.2	0	Cytoplasm;Nucleus	Maturity-onset diabetes of the young 6;Diabetes mellitus, non-insulin-dependent	Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).	Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth. Phosphorylated by MAPK1; phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells (By similarity).	NA	Maturity onset diabetes of the young;Regulation of gene expression in beta cells;Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	PE1	2
+NX_Q13563	Polycystin-2	968	109691	5.49	6	Golgi apparatus;Endoplasmic reticulum membrane;Cell membrane;Basolateral cell membrane;Endoplasmic reticulum;Cytoplasmic vesicle membrane;Cilium membrane	Polycystic kidney disease 2 with or without polycystic liver disease	Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Can also form a functional, homotetrameric ion channel (PubMed:29899465). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity).	N-glycosylated. The four subunits in a tetramer probably differ in the extent of glycosylation; simultaneous glycosylation of all experimentally validated sites would probably create steric hindrance. Thus, glycosylation at Asn-305 is not compatible with glycosylation at Asn-328; only one of these two residues is glycosylated at a given time.;Phosphorylated. Phosphorylation is important for protein function; a mutant that lacks the N-terminal phosphorylation sites cannot complement a zebrafish pkd2-deficient mutant (PubMed:16551655). PKD-mediated phosphorylation at the C-terminus regulates its function in the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:20881056). PKA-mediated phosphorylation at a C-terminal site strongly increases the open probability of the channel, but does not increase single channel conductance (PubMed:26269590).	Belongs to the polycystin family.	VxPx cargo-targeting to cilium	PE1	4
+NX_Q13564	NEDD8-activating enzyme E1 regulatory subunit	534	60246	5.25	0	Cytoplasm;Cell membrane;Nucleoplasm;Centrosome;Cytoskeleton	NA	Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.	Ubiquitinated by TRIP12, leading to its degradation by the proteasome.	Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Protein modification; protein neddylation.;Alzheimer's disease;Neddylation	PE1	16
+NX_Q13568	Interferon regulatory factor 5	498	56044	5.54	0	Cytoplasm;Nucleus	Inflammatory bowel disease 14;Systemic lupus erythematosus 10;Rheumatoid arthritis	Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.	Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.;'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.;IRF5 is phosphorylated by TBK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the IRF family.	Toll-like receptor signaling pathway;Interferon gamma signaling;Interferon alpha/beta signaling	PE1	7
+NX_Q13569	G/T mismatch-specific thymine DNA glycosylase	410	46053	6.36	0	Nucleoplasm;Nucleus	NA	DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.	Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA.	Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.	Base excision repair;SUMOylation of DNA damage response and repair proteins;Displacement of DNA glycosylase by APEX1;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;TET1,2,3 and TDG demethylate DNA	PE1	12
+NX_Q13571	Lysosomal-associated transmembrane protein 5	262	29937	8.95	5	Cytosol;Lysosome membrane	NA	May have a special functional role during embryogenesis and in adult hematopoietic cells.	NA	Belongs to the LAPTM4/LAPTM5 transporter family.	Lysosome	PE1	1
+NX_Q13572	Inositol-tetrakisphosphate 1-kinase	414	45621	5.78	0	Mitochondrion	NA	Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525).	Acetylation by EP300 and CREBBP destabilizes ITPK1, and down-regulates enzymatic activity. Deacetylated by SIRT1.	Belongs to the ITPK1 family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Factors involved in megakaryocyte development and platelet production;Synthesis of IP3 and IP4 in the cytosol;Synthesis of pyrophosphates in the cytosol	PE1	14
+NX_Q13573	SNW domain-containing protein 1	536	61494	9.52	0	Nucleoplasm;Cytosol;Nucleus	NA	(Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter.;(Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters.;Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD.	NA	Belongs to the SNW family.	Spliceosome;Notch signaling pathway;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;mRNA Splicing - Major Pathway;Pre-NOTCH Transcription and Translation;Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE1	14
+NX_Q13574	Diacylglycerol kinase zeta	1117	124128	9.24	0	Cytoplasm;Nucleus speckle;Cell membrane;Lamellipodium;Nucleus	NA	Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols.;But not isoform 1 regulates RASGRP1 activity (PubMed:11257115). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Activates PIP5K1A activity via generation of phosphatidic acid (PubMed:15157668).	Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.	Belongs to the eukaryotic diacylglycerol kinase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Effects of PIP2 hydrolysis	PE1	11
+NX_Q13576	Ras GTPase-activating-like protein IQGAP2	1575	180578	5.47	0	Cytoplasmic vesicle;Cell membrane	NA	Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.	NA	NA	Regulation of actin cytoskeleton;RHO GTPases activate IQGAPs;Neutrophil degranulation	PE1	5
+NX_Q13585	Melatonin-related receptor	617	67369	7.64	7	Nucleoplasm;Cell membrane	NA	Does not bind melatonin.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction	PE1	X
+NX_Q13586	Stromal interaction molecule 1	685	77423	6.19	1	Endoplasmic reticulum membrane;Cell membrane;Sarcoplasmic reticulum;Endoplasmic reticulum;Cytoskeleton	Myopathy, tubular aggregate, 1;Stormorken syndrome;Immunodeficiency 10	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679).	Glycosylation is required for cell surface expression.;Phosphorylated predominantly on Ser residues.	NA	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Elevation of cytosolic Ca2+ levels;Ion homeostasis	PE1	11
+NX_Q13588	GRB2-related adapter protein	217	25337	6.54	0	Membrane;Synapse	Deafness, autosomal recessive, 114	Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing (PubMed:30610177).	NA	Belongs to the GRB2/sem-5/DRK family.	Signaling by SCF-KIT	PE1	17
+NX_Q13591	Semaphorin-5A	1074	120615	7.03	1	Membrane	NA	Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.	NA	Belongs to the semaphorin family.	Axon guidance;O-glycosylation of TSR domain-containing proteins;Other semaphorin interactions;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	5
+NX_Q13595	Transformer-2 protein homolog alpha	282	32689	11.27	0	Nucleoplasm;Cytoplasmic vesicle;Nucleus;Nucleolus	NA	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.	Phosphorylated in the RS domains.	Belongs to the splicing factor SR family.	Spliceosome	PE1	7
+NX_Q13596	Sorting nexin-1	522	59070	5.08	0	Endosome membrane;trans-Golgi network membrane;Endosome;Lamellipodium;Lysosome;Early endosome membrane	NA	Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).	NA	Belongs to the sorting nexin family.	NA	PE1	15
+NX_Q13601	KRR1 small subunit processome component homolog	381	43665	9.78	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	NA	Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).	NA	Belongs to the KRR1 family.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	12
+NX_Q13606	Olfactory receptor 5I1	314	36049	8.25	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q13607	Olfactory receptor 2F1	317	35350	8.65	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_Q13608	Peroxisome assembly factor 2	980	104061	5.96	0	Cytoplasm;Photoreceptor outer segment;Peroxisome membrane;Nucleoplasm;Cytoplasmic vesicle;Nucleus	Peroxisome biogenesis disorder 4A;Peroxisome biogenesis disorder complementation group 4;Heimler syndrome 2;Peroxisome biogenesis disorder 4B	Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.	NA	Belongs to the AAA ATPase family.	Peroxisome;Peroxisomal protein import	PE1	6
+NX_Q13609	Deoxyribonuclease gamma	305	35504	9.35	0	Golgi apparatus;Endoplasmic reticulum;Secreted;Nucleus	Systemic lupus erythematosus 16	Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA (PubMed:9070308, PubMed:9714828, PubMed:14646506, PubMed:10807908, PubMed:27293190). Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis (PubMed:23229555, PubMed:24312463). The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (By similarity). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:27293190). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).	Poly-ADP-ribosylated by PARP1. ADP-ribosylation negatively regulates enzymatic activity during apoptosis.	Belongs to the DNase I family.	NA	PE1	3
+NX_Q13610	Periodic tryptophan protein 1 homolog	501	55828	4.6	0	Golgi apparatus;Nucleus;Nucleolus;Chromosome	NA	Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309).	NA	Belongs to the WD repeat PWP1 family.	NA	PE1	12
+NX_Q13613	Myotubularin-related protein 1	665	74678	6.69	0	Cytoplasm;Centrosome;Cell membrane	NA	Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:11733541, PubMed:27018598). Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown by PubMed:27018598, while PubMed:11733541 find no activity with this substrate.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Fructose and mannose metabolism;Synthesis of PIPs at the plasma membrane	PE1	X
+NX_Q13614	Myotubularin-related protein 2	643	73381	7.02	0	Cytoplasm;Endosome membrane;Early endosome membrane;Cytoplasmic vesicle;Axon;Perinuclear region	Charcot-Marie-Tooth disease 4B1	Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11733541, PubMed:12668758, PubMed:21372139, PubMed:14690594). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (By similarity). Stabilizes SBF2/MTMR13 at the membranes (By similarity). Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity).	Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures.	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Fructose and mannose metabolism;Synthesis of PIPs at the ER membrane;Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane	PE1	11
+NX_Q13615	Myotubularin-related protein 3	1198	133619	5.51	0	Membrane;Cytoplasm;Cytosol;Nucleoplasm	NA	Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Macroautophagy;Synthesis of PIPs at the plasma membrane	PE1	22
+NX_Q13616	Cullin-1	776	89679	8.19	0	Cytoplasm;Nucleoplasm;Nucleolus	NA	Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143, PubMed:25503564). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of CCNE1, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.	Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (PubMed:10597293, PubMed:10713156, PubMed:15537541, PubMed:18805092).;(Microbial infection) Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome (PubMed:20190741).	Belongs to the cullin family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Wnt signaling pathway;TGF-beta signaling pathway;Circadian rhythm - mammal;Herpes simplex infection;Activation of NF-kappaB in B cells;SCF-beta-TrCP mediated degradation of Emi1;Degradation of beta-catenin by the destruction complex;FCERI mediated NF-kB activation;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;Orc1 removal from chromatin;Antigen processing: Ubiquitination &amp; Proteasome degradation;Regulation of PLK1 Activity at G2/M Transition;Downstream TCR signaling;SCF(Skp2)-mediated degradation of p27/p21;Circadian Clock;Prolactin receptor signaling;Iron uptake and transport;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Cyclin D associated events in G1;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX2 expression and activity;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling	PE1	7
+NX_Q13617	Cullin-2	745	86983	6.46	0	Nucleoplasm	NA	Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).	Neddylated; which enhances the ubiquitination activity of ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes. CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity).	Belongs to the cullin family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Pathways in cancer;Renal cell carcinoma;Antigen processing: Ubiquitination &amp; Proteasome degradation;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Neddylation;Regulation of expression of SLITs and ROBOs	PE1	10
+NX_Q13618	Cullin-3	768	88930	8.68	0	Cytoplasm;Golgi apparatus;Spindle pole;Centrosome;Flagellum;Spindle;Nucleus	Pseudohypoaldosteronism 2E	Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation (PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway (PubMed:29769719). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (PubMed:15983046). In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (PubMed:25270598). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (PubMed:27798626). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525).	Neddylated. Attachment of NEDD8 is required for the E3 ubiquitin-protein ligase activity of the BCR complex. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.	Belongs to the cullin family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Degradation of DVL;Hedgehog 'on' state;Regulation of RAS by GAPs;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	2
+NX_Q13619	Cullin-4A	759	87680	8.29	0	NA	NA	Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). With CUL4B, contributes to ribosome biogenesis (PubMed:26711351).	Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.;(Microbial infection) Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome.	Belongs to the cullin family.	Protein modification; protein ubiquitination.;Nucleotide excision repair;Ubiquitin mediated proteolysis;Recognition of DNA damage by PCNA-containing replication complex;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;DNA Damage Recognition in GG-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;Neddylation	PE1	13
+NX_Q13620	Cullin-4B	913	103982	7.01	0	Nucleus	Mental retardation, X-linked, syndromic, 15	Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. With CUL4A, contributes to ribosome biogenesis (PubMed:26711351).	Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.	Belongs to the cullin family.	Protein modification; protein ubiquitination.;Nucleotide excision repair;Ubiquitin mediated proteolysis;Recognition of DNA damage by PCNA-containing replication complex;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;DNA Damage Recognition in GG-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;Neddylation	PE1	X
+NX_Q13621	Solute carrier family 12 member 1	1099	121450	7.18	12	Membrane;Cytoplasmic vesicle;Nucleoplasm	Bartter syndrome 1, antenatal	Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system.	NA	Belongs to the SLC12A transporter family.	Cation-coupled Chloride cotransporters;Defective SLC12A1 causes Bartter syndrome 1 (BS1)	PE1	15
+NX_Q13625	Apoptosis-stimulating of p53 protein 2	1128	125616	5.78	0	Cytosol;Cell junction;Perinuclear region;Nucleus	NA	Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.	TP53BP2 is phosphorylated by YES1 (Phosphotyrosine:PTM-0255)	Belongs to the ASPP family.	Activation of PUMA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of Death Receptors and Ligands;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Regulation of TP53 Activity through Association with Co-factors	PE1	1
+NX_Q13627	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	763	85584	8.9	0	Nucleolus;Cytosol;Nucleus speckle;Nucleus	Mental retardation, autosomal dominant 7	Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).	Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).;DYRK1A is phosphorylated by LATS2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.	G0 and Early G1	PE1	21
+NX_Q13630	GDP-L-fucose synthase	321	35893	6.12	0	Nucleoplasm;Cytosol	NA	Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.	NA	Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.	Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.;Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;GDP-fucose biosynthesis	PE1	8
+NX_Q13634	Cadherin-18	790	88073	4.98	1	Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	Adherens junctions interactions	PE1	5
+NX_Q13635	Protein patched homolog 1	1447	160545	6.42	12	Golgi apparatus;Cell membrane	Holoprosencephaly 7;Basal cell carcinoma;Basal cell nevus syndrome	Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.	Glycosylation is necessary for SHH binding.;In the absence of Hh ligands, ubiquitination by ITCH at Lys-1426 promotes endocytosis and both proteasomal and lysosomal degradation.	Belongs to the patched family.	Hedgehog signaling pathway;Pathways in cancer;Basal cell carcinoma;Hedgehog 'on' state;Class B/2 (Secretin family receptors);Hedgehog 'off' state;Activation of SMO;Ligand-receptor interactions	PE1	9
+NX_Q13636	Ras-related protein Rab-31	194	21569	6.59	0	trans-Golgi network;Cytoplasm;Phagosome membrane;Early endosome;trans-Golgi network membrane;Phagosome	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.	NA	Belongs to the small GTPase superfamily. Rab family.	Endocytosis;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	18
+NX_Q13637	Ras-related protein Rab-32	225	24997	6.08	0	Mitochondrion outer membrane;Mitochondrion;Phagosome membrane;Melanosome;Phagosome;Cytosol;Melanosome membrane	NA	Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).	NA	Belongs to the small GTPase superfamily. Rab family.	RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	6
+NX_Q13639	5-hydroxytryptamine receptor 4	388	43761	8.06	7	Endosome;Cell membrane	NA	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.	HTR4 is phosphorylated by GRK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Serotonin receptors	PE1	5
+NX_Q13641	Trophoblast glycoprotein	420	46032	6.35	1	Nucleoplasm;Cell membrane	NA	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.	Highly glycosylated.	NA	NA	PE1	6
+NX_Q13642	Four and a half LIM domains protein 1	323	36263	9.25	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	Reducing body myopathy, X-linked 1A, severe, with infantile or early childhood onset;Reducing body myopathy, X-linked 1B, with late childhood or adult onset;Scapuloperoneal myopathy, X-linked dominant;Emery-Dreifuss muscular dystrophy 6, X-linked;Myopathy, X-linked, with postural muscle atrophy;Uruguay faciocardiomusculoskeletal syndrome	May have an involvement in muscle development or hypertrophy.	NA	NA	NA	PE1	X
+NX_Q13643	Four and a half LIM domains protein 3	280	31192	5.79	0	Cytoplasm;Nucleoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_Q13651	Interleukin-10 receptor subunit alpha	578	63003	5.23	1	Cytoplasm;Cell membrane	Inflammatory bowel disease 28	Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683).	Ubiquitinated by BTRC; ubiquitination leads to endocytosis and subsequent degradation of IL10RA.;Phosphorylated. Phosphorylation of the cytoplasmic tail induced STAT3 activation.	Belongs to the type II cytokine receptor family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Toxoplasmosis;Tuberculosis;Interleukin-10 signaling	PE1	11
+NX_Q13670	Putative postmeiotic segregation increased 2-like protein 11	270	28555	6.23	0	NA	NA	NA	NA	Belongs to the DNA mismatch repair MutL/HexB family.	NA	PE5	7
+NX_Q13671	Ras and Rab interactor 1	783	84099	8.3	0	Cytoplasm;Nucleus membrane;Membrane;Nucleoplasm;Cytoskeleton	NA	Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.	Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.	Belongs to the RIN (Ras interaction/interference) family.	RAB GEFs exchange GTP for GDP on RABs	PE1	11
+NX_Q13683	Integrin alpha-7	1181	128948	5.47	1	Membrane;Cytoplasmic vesicle;Nucleus speckle;Cell membrane	Muscular dystrophy congenital due to integrin alpha-7 deficiency	Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity.;Promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.	ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes.;A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin.	Belongs to the integrin alpha chain family.	Focal adhesion;ECM-receptor interaction;Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Integrin cell surface interactions;ECM proteoglycans;Laminin interactions	PE1	12
+NX_Q13685	Angio-associated migratory cell protein	434	46751	4.29	0	Cytoplasm;Cytosol;Cytoskeleton;Cell membrane	NA	Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.	NA	NA	NA	PE1	2
+NX_Q13686	Nucleic acid dioxygenase ALKBH1	389	43832	6.61	0	Endoplasmic reticulum;Nucleoplasm;Mitochondrion;Nucleus	NA	Dioxygenase that acts as on nucleic acids, such as DNA and tRNA (PubMed:18603530, PubMed:27745969, PubMed:27497299). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:18603530, PubMed:27497299). A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment (PubMed:27745969, PubMed:27497299). Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs (PubMed:27745969). Acts as a regulator of translation initiation and elongation in response to glucose deprivation: regulates both translation initiation, by mediating demethylation of tRNA(Met), and translation elongation, N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation (PubMed:27745969). In mitochondrion, specifically interacts with mt-tRNA(Met) and mediates oxidation of mt-tRNA(Met) methylated at cytosine(34) to form 5-formylcytosine (f(5)c) at this position (PubMed:27497299). Mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299). Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:30017583). N(6)-methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (By similarity). Demethylates mRNAs containing N(3)-methylcytidine modification (PubMed:31188562). Also able to repair alkylated single-stranded DNA by oxidative demethylation, but with low activity (PubMed:18603530). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites (PubMed:19959401). DNA lyase activity does not require alpha-ketboglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product (PubMed:19959401, PubMed:23577621). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation (By similarity).	NA	Belongs to the alkB family.	NA	PE1	14
+NX_Q13698	Voltage-dependent L-type calcium channel subunit alpha-1S	1873	212350	6.17	24	T-tubule	Thyrotoxic periodic paralysis 1;Malignant hyperthermia 5;Periodic paralysis hypokalemic 1	Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.	The alpha-1S subunit is found in two isoforms in the skeletal muscle: a minor form of 212 kDa containing the complete amino acid sequence, and a major form of 190 kDa derived from the full-length form by post-translational proteolysis close to Phe-1690.;Both the minor and major forms are phosphorylated in vitro by PKA. Phosphorylation by PKA activates the calcium channel.	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily.	MAPK signaling pathway;Calcium signaling pathway;Cardiac muscle contraction;Vascular smooth muscle contraction;Cholinergic synapse;GABAergic synapse;GnRH signaling pathway;Alzheimer's disease;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;NCAM1 interactions;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	1
+NX_Q13702	43 kDa receptor-associated protein of the synapse	412	46328	8.48	0	Cell membrane;Postsynaptic cell membrane;Centrosome;Cytosol;Cytoskeleton	Fetal akinesia deformation sequence 2;Myasthenic syndrome, congenital, 11, associated with acetylcholine receptor deficiency	Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.	Ubiquitinated by the BCR(KLHL8) complex, leading to its degradation.	Belongs to the RAPsyn family.	NA	PE1	11
+NX_Q13705	Activin receptor type-2B	512	57724	5.46	1	Nucleoplasm;Cytosol;Nucleus;Cell membrane	Heterotaxy, visceral, 4, autosomal	Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.	Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity.	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Signaling by BMP;Signaling by NODAL;Signaling by Activin;Regulation of signaling by NODAL	PE1	3
+NX_Q13724	Mannosyl-oligosaccharide glucosidase	837	91918	8.97	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	Type IIb congenital disorder of glycosylation	Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.	NA	Belongs to the glycosyl hydrolase 63 family.	Glycan metabolism; N-glycan degradation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;Defective MOGS causes MOGS-CDG (CDG-2b);N-glycan trimming in the ER and Calnexin/Calreticulin cycle	PE1	2
+NX_Q13733	Sodium/potassium-transporting ATPase subunit alpha-4	1029	114166	6.23	10	Cell membrane	NA	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.	Cardiac muscle contraction;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Protein digestion and absorption;Bile secretion;Mineral absorption;Ion transport by P-type ATPases;Ion homeostasis	PE1	1
+NX_Q13740	CD166 antigen	583	65102	5.92	1	Axon;Dendrite;Secreted;Cell membrane	NA	Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity).;Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.	Glycosylated.	NA	Cell adhesion molecules (CAMs);L1CAM interactions	PE1	3
+NX_Q13751	Laminin subunit beta-3	1172	129572	7.14	0	Cytoplasmic vesicle;Basement membrane	Epidermolysis bullosa, junctional, Herlitz type;Generalized atrophic benign epidermolysis bullosa;Amelogenesis imperfecta 1A	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	NA	NA	Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer;Degradation of the extracellular matrix;Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly;Non-integrin membrane-ECM interactions;Laminin interactions;Anchoring fibril formation;MET activates PTK2 signaling	PE1	1
+NX_Q13753	Laminin subunit gamma-2	1193	130976	5.83	0	Basement membrane;Cytosol	Epidermolysis bullosa, junctional, Herlitz type	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.	NA	NA	Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer;Degradation of the extracellular matrix;Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly;Non-integrin membrane-ECM interactions;Laminin interactions;Anchoring fibril formation;MET activates PTK2 signaling	PE1	1
+NX_Q13761	Runt-related transcription factor 3	415	44356	9.53	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).	Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.;RUNX3 is phosphorylated by SRC (Phosphotyrosine:PTM-0255)	NA	Binding of TCF/LEF:CTNNB1 to target gene promoters;Regulation of RUNX3 expression and activity;RUNX3 regulates YAP1-mediated transcription;RUNX3 Regulates Immune Response and Cell Migration;RUNX3 regulates CDKN1A transcription;RUNX3 regulates WNT signaling;RUNX3 regulates NOTCH signaling;RUNX3 regulates RUNX1-mediated transcription;RUNX3 regulates p14-ARF;RUNX3 regulates BCL2L11 (BIM) transcription	PE1	1
+NX_Q13765	Nascent polypeptide-associated complex subunit alpha	215	23384	4.52	0	Cytoplasm;Nucleus	NA	Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.	Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation (By similarity). Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization.	Belongs to the NAC-alpha family.	NA	PE1	12
+NX_Q13769	THO complex subunit 5 homolog	683	78508	6.41	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.;Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.	Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes (By similarity). Phosphorylation at Tyr-225 modulates mRNA binding.	Belongs to the THOC5 family.	RNA transport;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	22
+NX_Q13772	Nuclear receptor coactivator 4	614	69726	5.72	0	Golgi apparatus;Cytosol;Nucleolus	NA	Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.	NA	NA	Pathways in cancer;Thyroid cancer	PE1	10
+NX_Q13790	Apolipoprotein F	326	35399	5.42	0	Secreted	NA	Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.	O-glycosylated with core 1 or possibly core 8 glycans.	Belongs to the apolipoprotein F family.	LDL remodeling	PE1	12
+NX_Q13794	Phorbol-12-myristate-13-acetate-induced protein 1	54	6030	10.3	0	Cytoplasmic vesicle;Mitochondrion	NA	Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.	NA	Belongs to the PMAIP1 family.	p53 signaling pathway;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Activation of NOXA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	PE1	18
+NX_Q13795	ADP-ribosylation factor-related protein 1	201	22614	7.5	0	trans-Golgi network;Golgi apparatus	NA	Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.	NA	Belongs to the small GTPase superfamily. Arf family.	Retrograde transport at the Trans-Golgi-Network	PE1	20
+NX_Q13796	Protein Shroom2	1616	176410	6.64	0	Cell membrane;Apical cell membrane;Cell junction;Tight junction;Cytosol;Cytoskeleton	NA	May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity).	NA	Belongs to the shroom family.	NA	PE1	X
+NX_Q13797	Integrin alpha-9	1035	114489	5.76	1	Cell membrane;Cell junction;Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.	NA	Belongs to the integrin alpha chain family.	Focal adhesion;ECM-receptor interaction;Cell adhesion molecules (CAMs);Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Signal transduction by L1;Integrin cell surface interactions;ECM proteoglycans	PE1	3
+NX_Q13813	Spectrin alpha chain, non-erythrocytic 1	2472	284539	5.22	0	Cytoplasmic vesicle;Cell cortex;Cytoskeleton	Epileptic encephalopathy, early infantile, 5	Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.	Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.	Belongs to the spectrin family.	Tight junction;RAF/MAP kinase cascade;Interaction between L1 and Ankyrins;Caspase-mediated cleavage of cytoskeletal proteins;Nephrin family interactions;NCAM signaling for neurite out-growth;COPI-mediated anterograde transport;Neutrophil degranulation	PE1	9
+NX_Q13822	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	863	98994	7.14	0	Golgi apparatus;Nucleoplasm;Secreted;Cytoskeleton	NA	Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931). Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573). Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949). May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor (PubMed:1733949, PubMed:11559573).	N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity.	Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.	Ether lipid metabolism;Vitamin B5 (pantothenate) metabolism	PE1	8
+NX_Q13823	Nucleolar GTP-binding protein 2	731	83655	9.27	0	Nucleolus	NA	GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195).	NA	Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Ribosome biogenesis in eukaryotes	PE1	1
+NX_Q13825	Methylglutaconyl-CoA hydratase, mitochondrial	339	35609	9.53	0	Mitochondrion	3-methylglutaconic aciduria 1	Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA (PubMed:11738050, PubMed:12434311, PubMed:12655555). Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Has very low enoyl-CoA hydratase activity (PubMed:7892223). Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs (PubMed:7892223).	NA	Belongs to the enoyl-CoA hydratase/isomerase family.	Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3.;Valine, leucine and isoleucine degradation;Metabolic pathways;Branched-chain amino acid catabolism	PE1	9
+NX_Q13829	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2	316	36204	8.26	0	Nucleolus;Endosome;Cytoplasm;Nucleus	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.	Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA.	Belongs to the BACURD family.	Protein modification; protein ubiquitination.	PE1	17
+NX_Q13835	Plakophilin-1	747	82861	9.29	0	Nucleoplasm;Desmosome;Nucleus;Cell membrane	Ectodermal dysplasia-skin fragility syndrome	Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.	NA	Belongs to the beta-catenin family.	Apoptotic cleavage of cell adhesion proteins;Neutrophil degranulation;Formation of the cornified envelope;Keratinization	PE1	1
+NX_Q13838	Spliceosome RNA helicase DDX39B	428	48991	5.44	0	Cytoplasm;Nucleus speckle;Nucleus	NA	Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect.;Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.	NA	Belongs to the DEAD box helicase family. DECD subfamily.	RNA transport;mRNA surveillance pathway;Spliceosome;Influenza A;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	6
+NX_Q13867	Bleomycin hydrolase	455	52562	5.87	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.	NA	Belongs to the peptidase C1 family.	Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	17
+NX_Q13868	Exosome complex component RRP4	293	32789	7.06	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	Short stature, hearing loss, retinitis pigmentosa, and distinctive facies	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.	NA	Belongs to the RRP4 family.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;mRNA decay by 3' to 5' exoribonuclease;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	9
+NX_Q13873	Bone morphogenetic protein receptor type-2	1038	115201	5.82	1	Nucleoplasm;Cell membrane	Pulmonary venoocclusive disease 1, autosomal dominant;Pulmonary hypertension, primary, 1	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.	NA	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Signaling by BMP	PE1	2
+NX_Q13875	Myelin-associated oligodendrocyte basic protein	183	20959	11.35	0	Cytosol;Perinuclear region	NA	May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.	NA	NA	Transcriptional Regulation by MECP2	PE1	3
+NX_Q13882	Protein-tyrosine kinase 6	451	51834	6.56	0	Cytoplasm;Cell membrane;Membrane;Nucleoplasm;Ruffle;Cytosol;Nucleus	NA	Inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.;Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.	Autophosphorylated. Autophosphorylation of Tyr-342 leads to an increase of kinase activity. Tyr-447 binds to the SH2 domain when phosphorylated and negatively regulates kinase activity.;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily.	SCF(Skp2)-mediated degradation of p27/p21;Cyclin D associated events in G1;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;PTK6 Expression;ERBB2 Activates PTK6 Signaling;PTK6 promotes HIF1A stabilization;PTK6 Activates STAT3;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;PTK6 Regulates Proteins Involved in RNA Processing;PTK6 Regulates Cell Cycle;PTK6 Down-Regulation	PE1	20
+NX_Q13884	Beta-1-syntrophin	538	58061	8.81	0	Cell junction;Sarcolemma;Cytoskeleton	NA	Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.	Phosphorylated by CaM-kinase II.	Belongs to the syntrophin family.	NA	PE1	8
+NX_Q13885	Tubulin beta-2A chain	445	49907	4.78	0	Cytoskeleton	Cortical dysplasia, complex, with other brain malformations 5	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).	Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	6
+NX_Q13886	Krueppel-like factor 9	244	27235	8.8	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835).	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	9
+NX_Q13887	Krueppel-like factor 5	457	50792	8.86	0	Golgi apparatus;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.	Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.	Belongs to the krueppel C2H2-type zinc-finger protein family.	Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of granulopoiesis	PE1	13
+NX_Q13888	General transcription factor IIH subunit 2	395	44419	6.28	0	Nucleus	NA	Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.	NA	Belongs to the GTF2H2 family.	Basal transcription factors;Nucleotide excision repair;Basal transcription factors;Nucleotide excision repair;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Tat-mediated elongation of the HIV-1 transcript;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;TP53 Regulates Transcription of DNA Repair Genes	PE1	5
+NX_Q13889	General transcription factor IIH subunit 3	308	34378	6.59	0	Nucleoplasm;Nucleus	NA	Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.	NA	Belongs to the TFB4 family.	Basal transcription factors;Nucleotide excision repair;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Tat-mediated elongation of the HIV-1 transcript;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;TP53 Regulates Transcription of DNA Repair Genes	PE1	12
+NX_Q13895	Bystin	437	49601	8.19	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.	NA	Belongs to the bystin family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	6
+NX_Q13901	Nuclear nucleic acid-binding protein C1D	141	16019	9	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	NA	Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).	Phosphorylated by PRKDC.	Belongs to the C1D family.	RNA degradation;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	2
+NX_Q13905	Rap guanine nucleotide exchange factor 1	1077	120548	5.64	0	Cytoplasmic vesicle;Early endosome	NA	Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.	Phosphorylation at Tyr-504 enhances activity as Rap guanine nucleotide exchange factor.	NA	Regulation of signaling by CBL;Frs2-mediated activation;Downstream signal transduction;MET activates RAP1 and RAC1;Erythropoietin activates RAS	PE1	9
+NX_Q13907	Isopentenyl-diphosphate Delta-isomerase 1	227	26319	5.93	0	Peroxisome	NA	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).	NA	Belongs to the IPP isomerase type 1 family.	Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.;Terpenoid backbone biosynthesis;Metabolic pathways;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	10
+NX_Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	2221	248977	6.33	24	T-tubule;Cell membrane;Perikaryon;Sarcolemma;Postsynaptic density;Dendrite	Brugada syndrome 3;Timothy syndrome	(Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930).;Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).	Phosphorylation by PKA activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA.	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.	MAPK signaling pathway;Calcium signaling pathway;Cardiac muscle contraction;Vascular smooth muscle contraction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;GnRH signaling pathway;Type II diabetes mellitus;Alzheimer's disease;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;NCAM1 interactions;Adrenaline,noradrenaline inhibits insulin secretion;Regulation of insulin secretion;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	12
+NX_Q13938	Calcyphosin	275	30240	5.67	0	Nucleoplasm;Cytoplasm;Cytosol;Cell membrane	NA	Calcium-binding protein. May play a role in cellular signaling events (Potential).	NA	NA	NA	PE1	19
+NX_Q13939	Calicin	588	66582	8.49	0	Calyx	NA	Possible morphogenetic cytoskeletal element in spermiogenic differentiation.	NA	NA	NA	PE1	9
+NX_Q13946	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	482	55505	7.1	0	Cytoplasm;Cytosol	NA	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.;Purine metabolism;G alpha (s) signalling events	PE1	8
+NX_Q13948	Protein CASP	678	77455	5.35	1	Golgi apparatus membrane	NA	May be involved in intra-Golgi retrograde transport.	NA	Belongs to the CASP family.	Intra-Golgi traffic	PE1	7
+NX_Q13950	Runt-related transcription factor 2	521	56648	9.03	0	Nucleoplasm;Nucleus	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly;Cleidocranial dysplasia	Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28738062, PubMed:28703881). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.	Phosphorylated; probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation (By similarity). Phosphorylation at Ser-451 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression.;Is phosphorylated on Ser-340.;RUNX2 is phosphorylated by HIPK3	NA	YAP1- and WWTR1 (TAZ)-stimulated gene expression;Regulation of RUNX2 expression and activity;Transcriptional regulation by RUNX2;RUNX2 regulates osteoblast differentiation;RUNX2 regulates genes involved in cell migration;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX2 regulates bone development;RUNX2 regulates chondrocyte maturation;RUNX2 regulates genes involved in differentiation of myeloid cells	PE1	6
+NX_Q13951	Core-binding factor subunit beta	182	21508	6.23	0	Nucleoplasm;Cytosol;Nucleus	NA	Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.	NA	Belongs to the CBF-beta family.	Regulation of RUNX3 expression and activity;RUNX3 Regulates Immune Response and Cell Migration;RUNX3 regulates RUNX1-mediated transcription;RUNX3 regulates p14-ARF;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Transcriptional regulation by RUNX2;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of RUNX1 Expression and Activity;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;RUNX1 regulates estrogen receptor mediated transcription;RUNX1 regulates transcription of genes involved in WNT signaling;RUNX2 regulates osteoblast differentiation;RUNX2 regulates genes involved in cell migration;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes;RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs);RUNX1 regulates transcription of genes involved in BCR signaling;RUNX2 regulates bone development;RUNX2 regulates chondrocyte maturation;RUNX2 regulates genes involved in differentiation of myeloid cells;RUNX1 regulates expression of components of tight junctions;RUNX1 regulates transcription of genes involved in interleukin signaling;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	16
+NX_Q13952	Nuclear transcription factor Y subunit gamma	458	50302	5.78	0	Nucleoplasm;Nucleus	NA	Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.	NA	Belongs to the NFYC/HAP5 subunit family.	Antigen processing and presentation;Tuberculosis;PPARA activates gene expression;ATF4 activates genes in response to endoplasmic reticulum stress;Activation of gene expression by SREBF (SREBP);ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes	PE1	1
+NX_Q13956	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	83	9074	9.3	0	NA	Cone dystrophy, retinal 3A	Participates in processes of transmission and amplification of the visual signal. CGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.	NA	Belongs to the rod/cone cGMP-PDE gamma subunit family.	Purine metabolism	PE1	12
+NX_Q13972	Ras-specific guanine nucleotide-releasing factor 1	1273	145234	7.18	0	Golgi apparatus	NA	Promotes the exchange of Ras-bound GDP by GTP.	Ubiquitinated and degraded following phosphorylation by PLK2.;Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.;Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome.;RASGRF1 is phosphorylated by TNK2 (Phosphotyrosine:PTM-0255);RASGRF1 is phosphorylated by PLK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);RASGRF1 is phosphorylated by SRC	NA	MAPK signaling pathway;Focal adhesion;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor	PE1	15
+NX_Q13976	cGMP-dependent protein kinase 1	671	76364	5.74	0	Cytoplasm;Cytosol;Cytoplasmic vesicle	Aortic aneurysm, familial thoracic 8	Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates MRVI1/IRAG and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle.	Autophosphorylation increases kinase activity.;65 kDa monomer is produced by proteolytic cleavage.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.	Vascular smooth muscle contraction;Gap junction;Long-term depression;Olfactory transduction;Salivary secretion;Ca2+ pathway;Rap1 signalling;cGMP effects	PE1	10
+NX_Q14002	Carcinoembryonic antigen-related cell adhesion molecule 7	265	29379	5.36	0	Apical cell membrane;Cell membrane	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	19
+NX_Q14003	Potassium voltage-gated channel subfamily C member 3	757	80578	6.08	6	Cell cortex;Presynaptic cell membrane;Cell membrane;Perikaryon;Dendritic spine membrane;Axon;Dendrite;Cytoskeleton	Spinocerebellar ataxia 13	Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484).	N-glycosylated.	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily.	Voltage gated Potassium channels	PE1	19
+NX_Q14004	Cyclin-dependent kinase 13	1512	164923	9.71	0	Nucleus speckle	Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder	Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	TP53 Regulates Transcription of DNA Repair Genes;Neutrophil degranulation	PE1	7
+NX_Q14005	Pro-interleukin-16	1332	141752	8.34	0	Cytoplasm;Nucleus speckle;Cell membrane;Secreted;Cytosol;Nucleus;Midbody ring	NA	Is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.;Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.;May act as a scaffolding protein that anchors ion channels in the membrane.	Is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.	NA	Other interleukin signaling	PE1	15
+NX_Q14008	Cytoskeleton-associated protein 5	2032	225495	7.95	0	Cell membrane;Nucleolus;Spindle pole;Centrosome;Spindle;Kinetochore	NA	Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448).	NA	Belongs to the TOG/XMAP215 family.	Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Recruitment of NuMA to mitotic centrosomes;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;AURKA Activation by TPX2	PE1	11
+NX_Q14011	Cold-inducible RNA-binding protein	172	18648	9.51	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.	Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).;Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation.	NA	NA	PE1	19
+NX_Q14012	Calcium/calmodulin-dependent protein kinase type 1	370	41337	5.12	0	Cytoplasm;Cytosol;Nucleus	NA	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.	Polybiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL12), leading to proteasomal degradation.;Phosphorylated by CaMKK1 and CaMKK2 on Thr-177.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	Negative regulation of NMDA receptor-mediated neuronal transmission;Activation of RAC1 downstream of NMDARs	PE1	3
+NX_Q14019	Coactosin-like protein	142	15945	5.54	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.	NA	Belongs to the actin-binding proteins ADF family. Coactosin subfamily.	Neutrophil degranulation	PE1	16
+NX_Q14028	Cyclic nucleotide-gated cation channel beta-1	1251	139678	4.76	6	Membrane;Cytoplasmic vesicle;Cytosol	Retinitis pigmentosa 45	Is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.;Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.	NA	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB1 subfamily.	Olfactory transduction;Phototransduction;VxPx cargo-targeting to cilium;Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade	PE1	16
+NX_Q14031	Collagen alpha-6(IV) chain	1691	163807	9.31	0	Endoplasmic reticulum;Basement membrane	Deafness, X-linked, 6	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.;Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.;The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.	Belongs to the type IV collagen family.	Focal adhesion;ECM-receptor interaction;Protein digestion and absorption;Amoebiasis;Pathways in cancer;Small cell lung cancer;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Non-integrin membrane-ECM interactions;Laminin interactions;Crosslinking of collagen fibrils;Anchoring fibril formation;Extracellular matrix organization;Collagen chain trimerization	PE1	X
+NX_Q14032	Bile acid-CoA:amino acid N-acyltransferase	418	46299	6.5	0	Peroxisome;Cytosol;Cytoplasmic vesicle	Familial hypercholanemia	Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PubMed:12810727, PubMed:8034703, PubMed:2037576, PubMed:12239217). More than 95% of the BAs are N-acyl amidates with glycine and taurine (PubMed:8034703). Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (PubMed:12810727). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (PubMed:12810727). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (PubMed:12810727, PubMed:8034703, PubMed:12239217). In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (PubMed:12810727).	NA	Belongs to the C/M/P thioester hydrolase family.	Primary bile acid biosynthesis;Taurine and hypotaurine metabolism;Biosynthesis of unsaturated fatty acids;Metabolic pathways;Peroxisome;Bile secretion;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Recycling of bile acids and salts;Peroxisomal protein import	PE1	9
+NX_Q14050	Collagen alpha-3(IX) chain	684	63616	7.58	0	Nucleoplasm;Extracellular matrix;Cytoskeleton	Intervertebral disc disease;Multiple epiphyseal dysplasia 3	Structural component of hyaline cartilage and vitreous of the eye.	Covalently linked to the telopeptides of type II collagen by lysine-derived cross-links.;Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.	Protein digestion and absorption;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	20
+NX_Q14055	Collagen alpha-2(IX) chain	689	65131	9.23	0	Nucleoplasm;Extracellular matrix;Cytoplasmic vesicle	Multiple epiphyseal dysplasia 2;Intervertebral disc disease;Stickler syndrome 5	Structural component of hyaline cartilage and vitreous of the eye.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.;Covalently linked to the telopeptides of type II collagen by lysine-derived cross-links.	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.	Protein digestion and absorption;Signaling by PDGF;NCAM1 interactions;Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	1
+NX_Q14061	Cytochrome c oxidase copper chaperone	63	6915	6.8	0	Cytoplasm;Mitochondrion intermembrane space;Mitochondrion	NA	Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).	NA	Belongs to the COX17 family.	Oxidative phosphorylation;Metabolic pathways;Mitochondrial protein import	PE1	3
+NX_Q14088	Ras-related protein Rab-33A	237	26593	8.07	0	Cytoplasmic vesicle;Cytoplasm;Cell membrane	NA	NA	NA	Belongs to the small GTPase superfamily. Rab family.	TBC/RABGAPs;RAB geranylgeranylation	PE1	X
+NX_Q14093	Cylicin-2	348	39079	9.74	0	Calyx	NA	Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.	NA	NA	NA	PE1	9
+NX_Q14094	Cyclin-I	377	42557	8.23	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the cyclin family.	NA	PE1	4
+NX_Q14103	Heterogeneous nuclear ribonucleoprotein D0	355	38434	7.61	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.	Arg-345 is dimethylated, probably to asymmetric dimethylarginine.;Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine phosphorylation (By similarity).;HNRNPD is phosphorylated by MAPK3	NA	AUF1 (hnRNP D0) binds and destabilizes mRNA;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA	PE1	4
+NX_Q14106	Protein Tob2	344	36632	6.45	0	Cytoplasm;Cytosol	NA	Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.	NA	Belongs to the BTG family.	RNA degradation	PE1	22
+NX_Q14108	Lysosome membrane protein 2	478	54290	5	2	Cytosol;Lysosome membrane	Epilepsy, progressive myoclonic 4, with or without renal failure	Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.;(Microbial infection) Acts as a receptor for enterovirus 71.	NA	Belongs to the CD36 family.	Lysosome;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	4
+NX_Q14112	Nidogen-2	1375	151254	5.09	0	Basement membrane;Cell membrane	NA	Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.	Highly N- and O-glycosylated.	NA	Laminin interactions	PE1	14
+NX_Q14114	Low-density lipoprotein receptor-related protein 8	963	105634	4.88	1	Secreted;Cell membrane	Myocardial infarction 1	Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity).	Ubiquitinated by MYLIP leading to degradation.;Tyrosine phosphorylated upon apoE binding.;Undergoes sequential, furin and gamma-secretase dependent, proteolytic processing, resulting in the extracellular release of the entire ligand-binding domain as a soluble polypeptide and in the intracellular domain (ICD) release into the cytoplasm. The gamma-secretase-dependent proteolytical processing occurs after the bulk of the extracellular domain has been shed, in a furin-dependent manner, in alternatively spliced isoforms carrying the furin cleavage site. Hypoglycosylation (mainly hypo-O-glycosylation) leads to increased extracellular cleavage, which in turn results in accelerating release of the intracellular domain (ICD) by the gamma-secretase. The resulting receptor fragment is able to inhibit Reelin signaling and in particular the Reelin-induced DAB1 phosphorylation (By similarity).;O-glycosylated. Some alternatively spliced isoforms lack the O-linked sugar domain (By similarity).	Belongs to the LDLR family.	Retinoid metabolism and transport;Platelet sensitization by LDL	PE1	1
+NX_Q14116	Interleukin-18	193	22326	4.54	0	Golgi apparatus;Nucleoplasm;Cytosol;Secreted	NA	A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).	The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.	Belongs to the IL-1 family.	Cytokine-cytokine receptor interaction;NOD-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Salmonella infection;Legionellosis;African trypanosomiasis;Malaria;Tuberculosis;Influenza A;Rheumatoid arthritis;Interleukin-1 processing;Interleukin-4 and Interleukin-13 signaling;Interleukin-10 signaling;Interleukin-18 signaling	PE1	11
+NX_Q14117	Dihydropyrimidinase	519	56630	6.81	0	NA	Dihydropyrimidinase deficiency	Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.	Carboxylation allows a single lysine to coordinate two zinc ions.	Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.	Pyrimidine metabolism;beta-Alanine metabolism;Pantothenate and CoA biosynthesis;Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine catabolism	PE1	8
+NX_Q14118	Dystroglycan	895	97441	8.71	1	Cell membrane;Postsynaptic cell membrane;Nucleoplasm;Extracellular space;Cytoplasmic vesicle;Sarcolemma;Cytoskeleton	Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A9;Muscular dystrophy-dystroglycanopathy limb-girdle C9	The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.;Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.;(Microbial infection) Alpha-dystroglycan acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:19324387, PubMed:17360738). Alpha-dystroglycan acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927).;Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells.	Autolytic cleavage produces the alpha and beta subunits. In cutaneous cells, as well as in certain pathological conditions, shedding of beta-dystroglcan can occur releasing a peptide of about 30 kDa.;The beta subunit is N-glycosylated.;SRC-mediated phosphorylation of the PPXY motif of the beta subunit recruits SH2 domain-containing proteins, but inhibits binding to WWW domain-containing proteins, DMD and UTRN. This phosphorylation also inhibits nuclear entry.;O-glycosylated. POMGNT1 catalyzes the initial addition of N-acetylglucosamine, giving rise to the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety and thus providing the necessary basis for the addition of further carbohydrate moieties (PubMed:27493216). Alpha-dystroglycan is heavily O-glycosylated comprising of up to two thirds of its mass and the carbohydrate composition differs depending on tissue type. Mucin-type O-glycosylation is important for ligand binding activity. O-mannosylation of alpha-DAG1 is found in high abundance in both brain and muscle where the most abundant glycan is Sia-alpha-2-3-Gal-beta-1-4-Glc-NAc-beta-1-2-Man. In muscle, glycosylation on Thr-317, Thr-319 and Thr-379 by a phosphorylated O-mannosyl glycan with the structure 2-(N-acetylamido)-2-deoxygalactosyl-beta-1,3-2-(N-acetylamido)-2-deoxyglucosyl-beta-1,4-6-phosphomannose is mediated by like-acetylglucosaminyltransferase (LARGE1) protein and is required for laminin binding (PubMed:20044576, PubMed:21987822, PubMed:24256719). O-mannosylation is also required for binding lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses. The O-glycosyl hexose on Thr-367, Thr-369, Thr-372, Thr-381 and Thr-388 is probably mannose. O-glycosylated in the N-terminal region with a core 1 or possibly core 8 glycan.	NA	ECM-receptor interaction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Viral myocarditis;ECM proteoglycans;Non-integrin membrane-ECM interactions;Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2;O-linked glycosylation;Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3;Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1;Regulation of expression of SLITs and ROBOs	PE1	3
+NX_Q14119	Vascular endothelial zinc finger 1	521	56931	9.62	0	Nucleoplasm;Nucleus	NA	Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	17
+NX_Q14123	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	709	80760	8.88	0	Nucleoplasm	Deafness, autosomal dominant, 74	Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8557689, PubMed:29860631). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.	Purine metabolism;Calcium signaling pathway;Olfactory transduction;Cam-PDE 1 activation	PE1	7
+NX_Q14126	Desmoglein-2	1118	122294	5.13	1	Cell junction;Desmosome;Cell membrane	Cardiomyopathy, dilated 1BB;Arrhythmogenic right ventricular dysplasia, familial, 10	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	NA	NA	Arrhythmogenic right ventricular cardiomyopathy (ARVC);Apoptotic cleavage of cell adhesion proteins;Formation of the cornified envelope;Keratinization	PE1	18
+NX_Q14129	Protein DGCR6	220	24989	7.02	0	Nucleus	NA	May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.	NA	Belongs to the gonadal family.	NA	PE1	22
+NX_Q14134	Tripartite motif-containing protein 29	588	65835	6.73	0	Cytoplasm;Nucleoplasm;Cytoskeleton;Lysosome	NA	Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.	Constitutively phosphorylated by PKC on serine/threonine in A431 cells.	NA	Interferon gamma signaling	PE1	11
+NX_Q14135	Transcription cofactor vestigial-like protein 4	290	30948	8.49	0	Nucleoplasm;Nucleolus;Nucleus	NA	May act as a specific coactivator for the mammalian TEFs.	NA	Belongs to the vestigial family.	NA	PE1	3
+NX_Q14137	Ribosome biogenesis protein BOP1	746	83630	5.8	0	Nucleoplasm;Nucleolus	NA	Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	NA	Belongs to the WD repeat BOP1/ERB1 family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	8
+NX_Q14139	Ubiquitin conjugation factor E4 A	1066	122561	5.11	0	Cytoplasm;Nucleus speckle	NA	Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.	NA	Belongs to the ubiquitin conjugation factor E4 family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	11
+NX_Q14140	SERTA domain-containing protein 2	314	33897	4.42	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.	Polyubiquitinated, which promotes proteasomal degradation.	NA	NA	PE1	2
+NX_Q14141	Septin-6	434	49717	6.24	0	Kinetochore;Cytoplasm;Cleavage furrow;Flagellum;Spindle;Midbody	NA	Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	NA	PE1	X
+NX_Q14142	Tripartite motif-containing protein 14	442	49773	8.13	0	Mitochondrion outer membrane;Nucleoplasm;Cytosol	NA	Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593).	Ubiquitinated (PubMed:24379373). Undergoes 'Lys-63'-linked polyubiquitination; this modification allows IKBKG/NEMO recruitment to MAVS.	Belongs to the TRIM/RBCC family.	Interferon gamma signaling	PE1	9
+NX_Q14145	Kelch-like ECH-associated protein 1	624	69666	6	0	Cytoplasm;Centriolar satellite;Nucleoplasm;Cytosol;Nucleus	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15983046, PubMed:15601839). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:19489739, PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835).	Degraded via a proteasomal-independent process during selective autophagy: interaction with phosphorylated SQSTM1/p62 sequesters KEAP1 in inclusion bodies, leading to its degradation.;Auto-ubiquitinated by the BCR(KEAP1) complex (PubMed:15572695, PubMed:15983046). Quinone-induced oxidative stress, but not sulforaphane, increases its ubiquitination (PubMed:15572695, PubMed:15983046). Ubiquitination and subsequent degradation is most pronounced following prolonged exposure of cells to oxidative stress, particularly in glutathione-deficient cells that are highly susceptible to oxidative stress (PubMed:15572695, PubMed:15983046).;Non-enzymatic covalent modifications of reactive cysteines by electrophile metabolites inactivate the BCR(KEAP1) complex (PubMed:17127771, PubMed:18251510, PubMed:29590092, PubMed:30323285). Accumulation of fumarate promotes the formation of cysteine S-succination (S-(2-succinyl)cysteine), leading to inactivate the BCR(KEAP1) complex and promote NFE2L2/NRF2 nuclear accumulation and activation (By similarity). Nitric oxide-dependent 8-Nitro-cGMP formation promotes cysteine guanylation (S-cGMP-cysteine), leading to NFE2L2/NRF2 nuclear accumulation and activation (By similarity). Itaconate, an anti-inflammatory metabolite generated in response to lipopolysaccharide, alkylates cysteines, activating NFE2L2/NRF2 (PubMed:29590092). Methylglyoxal, a reactive metabolite that accumulates when the glycolytic enzyme PGK1 is inhibited, promotes formation of a methylimidazole cross-link between proximal Cys-151 and Arg-135 on another KEAP1 molecule, resulting in an inactive dimer that inactivates the BCR(KEAP1) complex (PubMed:30323285).	Belongs to the KEAP1 family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Ub-specific processing proteases;Neddylation	PE1	19
+NX_Q14146	Unhealthy ribosome biogenesis protein 2 homolog	1524	170544	6.97	0	Nucleolus	NA	NA	NA	NA	NA	PE1	1
+NX_Q14147	Probable ATP-dependent RNA helicase DHX34	1143	128120	7.37	0	Nucleoplasm;Cytoskeleton	NA	Probable ATP-binding RNA helicase.	NA	Belongs to the DEAD box helicase family. DEAH subfamily.	NA	PE1	19
+NX_Q14149	MORC family CW-type zinc finger protein 3	939	107113	5.42	0	Nucleoplasm;Nucleus matrix;Mitochondrion;PML body	NA	Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).	Sumoylation is involved in interaction with PML and localization to PML nuclear bodies.	NA	NA	PE1	21
+NX_Q14151	Scaffold attachment factor B2	953	107473	5.84	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.	NA	NA	NA	PE1	19
+NX_Q14152	Eukaryotic translation initiation factor 3 subunit A	1382	166569	6.38	0	Cytoplasm;Nucleoplasm;Cytosol	NA	(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).;(Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634).;RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).	Phosphorylated. Phosphorylation is enhanced upon serum stimulation.	Belongs to the eIF-3 subunit A family.	RNA transport;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	10
+NX_Q14153	Protein FAM53B	422	45768	6.33	0	Cytosol;Nucleus	NA	Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization.	NA	Belongs to the FAM53 family.	NA	PE1	10
+NX_Q14154	DAP3-binding cell death enhancer 1	515	55920	9.37	0	Golgi apparatus;Nucleoplasm;Mitochondrion	NA	Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.	NA	NA	NA	PE1	5
+NX_Q14155	Rho guanine nucleotide exchange factor 7	803	90012	6.66	0	Ruffle;Lamellipodium;Cell cortex;Focal adhesion	NA	Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.	Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1.;ARHGEF7 is phosphorylated by LRRK2	NA	Regulation of actin cytoskeleton;Ephrin signaling;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;EGFR downregulation;Activation of RAC1 downstream of NMDARs	PE1	13
+NX_Q14156	Protein EFR3 homolog A	821	92924	6.24	0	Cytosol;Cell membrane	NA	Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825).	Palmitoylated at its N-terminus, anchoring the protein to the plasma membrane.	Belongs to the EFR3 family.	NA	PE1	8
+NX_Q14157	Ubiquitin-associated protein 2-like	1087	114535	6.61	0	Cytosol;Nucleus speckle	NA	Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).	Acetylated.	NA	NA	PE1	1
+NX_Q14159	DNA repair-scaffolding protein	915	100316	6.22	0	Nucleoplasm;Nucleus	NA	Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.	NA	NA	Resolution of D-loop Structures through Holliday Junction Intermediates	PE1	8
+NX_Q14160	Protein scribble homolog	1630	174885	5.01	0	Cytoplasm;Cell membrane;Adherens junction;Postsynapse;Cell junction;Nucleoplasm;Presynapse;Lamellipodium	Neural tube defects	Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.	Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.	Belongs to the LAP (LRR and PDZ) protein family.	Asymmetric localization of PCP proteins	PE1	8
+NX_Q14161	ARF GTPase-activating protein GIT2	759	84543	6.78	0	Cytoskeleton	NA	GTPase-activating protein for the ADP ribosylation factor family.	NA	NA	Endocytosis	PE1	12
+NX_Q14162	Scavenger receptor class F member 1	830	87387	5.98	1	Membrane	NA	Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).	NA	NA	Scavenging by Class F Receptors	PE1	17
+NX_Q14164	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	716	80462	7.91	0	Cytoplasm;Cytosol;PML body;Nucleus	NA	Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.	Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1.;'Lys-63'-linked polyubiquitinated at Lys-30 and Lys-401 by TRAF2:BIRC2 and TRAF2:BIRC3 complexes. Ubiquitination is induced by LPS, TNFA and interleukin-1 and required for full kinase activity and KF-kappa-B pathway activation.;Autophosphorylated and phosphorylated by IKBKB/IKKB. Phosphorylation at Ser-172 is enhanced by the interaction with DDX3X. Phosphorylated at Thr-501 upon IFN activation.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Hepatitis C;Measles;Influenza A;Herpes simplex infection;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;TRAF3-dependent IRF activation pathway;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;TICAM1-dependent activation of IRF3/IRF7;SUMOylation of immune response proteins	PE1	1
+NX_Q14165	Malectin	292	32234	5.27	1	Endoplasmic reticulum membrane	NA	Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).	NA	Belongs to the malectin family.	N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Neutrophil degranulation	PE1	12
+NX_Q14166	Tubulin--tyrosine ligase-like protein 12	644	74404	5.33	0	Cytoplasm;Cell membrane;Centrosome;Cytosol;Nucleus;Spindle;Midbody	NA	Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935).	NA	Belongs to the tubulin--tyrosine ligase family.	Carboxyterminal post-translational modifications of tubulin	PE1	22
+NX_Q14168	MAGUK p55 subfamily member 2	576	64581	6.32	0	Mitochondrion;Membrane;Postsynaptic density;Cytosol;Dendrite;Cytoskeleton	NA	Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017).	Phosphorylated by SRC.	Belongs to the MAGUK family.	NA	PE1	17
+NX_Q14181	DNA polymerase alpha subunit B	598	65948	5.13	0	Nucleoplasm;Nucleus	NA	May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.	Phosphorylated in a cell cycle-dependent manner, in G2/M phase.	Belongs to the DNA polymerase alpha subunit B family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Activation of the pre-replicative complex;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;Telomere C-strand synthesis initiation;DNA replication initiation	PE1	11
+NX_Q14183	Double C2-like domain-containing protein alpha	400	43959	6.83	0	Synaptosome;Cell junction;Nucleolus;Nucleoplasm;Synaptic vesicle membrane;Lysosome	NA	Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.	NA	NA	NA	PE1	16
+NX_Q14184	Double C2-like domain-containing protein beta	412	45922	8.25	0	Cytoplasm;Cytoplasmic granule;Cell membrane	NA	Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity).	NA	NA	NA	PE1	17
+NX_Q14185	Dedicator of cytokinesis protein 1	1865	215346	7.29	0	Membrane;Nucleoplasm;Cytoplasm	NA	Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).	NA	Belongs to the DOCK family.	Focal adhesion;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Shigellosis;Regulation of actin dynamics for phagocytic cup formation;Factors involved in megakaryocyte development and platelet production;VEGFA-VEGFR2 Pathway;DCC mediated attractive signaling;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	PE1	10
+NX_Q14186	Transcription factor Dp-1	410	45070	5.74	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).	Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.;Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation.;TFDP1 is phosphorylated by NLK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the E2F/DP family.	Cell cycle;TGF-beta signaling pathway;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Oxidative Stress Induced Senescence;G0 and Early G1;G1/S-Specific Transcription;Pre-NOTCH Transcription and Translation;Cyclin E associated events during G1/S transition;Oncogene Induced Senescence;Cyclin A:Cdk2-associated events at S phase entry;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Cyclin D associated events in G1;Activation of PUMA and translocation to mitochondria;Activation of NOXA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;Transcriptional Regulation by E2F6;Transcriptional regulation of granulopoiesis	PE1	13
+NX_Q14188	Transcription factor Dp-2	446	49236	6.17	0	Nucleoplasm;Spindle;Nucleus;Cytoplasmic vesicle	NA	Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).	Ser-24 is probably phosphorylated by CDK2.	Belongs to the E2F/DP family.	Cell cycle;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Oxidative Stress Induced Senescence;G0 and Early G1;G1/S-Specific Transcription;Pre-NOTCH Transcription and Translation;Cyclin E associated events during G1/S transition;Oncogene Induced Senescence;Cyclin A:Cdk2-associated events at S phase entry;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Cyclin D associated events in G1;Activation of PUMA and translocation to mitochondria;Activation of NOXA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;Transcriptional Regulation by E2F6;Transcriptional regulation of granulopoiesis	PE1	3
+NX_Q14190	Single-minded homolog 2	667	73219	9.03	0	Nucleoplasm;Nucleus	NA	Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.	NA	NA	NA	PE1	21
+NX_Q14191	Werner syndrome ATP-dependent helicase	1432	162461	5.96	0	Nucleoplasm;Nucleolus;Nucleus speckle;Nucleus	Colorectal cancer;Werner syndrome	Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.	Phosphorylated by PRKDC.;WRN is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	Belongs to the helicase family. RecQ subfamily.	SUMOylation of DNA damage response and repair proteins;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	8
+NX_Q14192	Four and a half LIM domains protein 2	279	32193	7.8	0	Cytoplasm;Focal adhesion;Z line;Nucleus;Cytoskeleton	NA	May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).	NA	NA	Osteoclast differentiation;PPARA activates gene expression	PE1	2
+NX_Q14194	Dihydropyrimidinase-related protein 1	572	62184	6.55	0	Cytoplasm;Cytosol;Spindle;Centrosome	NA	Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.	NA	Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.	CRMPs in Sema3A signaling	PE1	4
+NX_Q14195	Dihydropyrimidinase-related protein 3	570	61963	6.04	0	Cytoplasm;Cytosol;Growth cone	NA	Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).	Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.	Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.	CRMPs in Sema3A signaling	PE1	5
+NX_Q14197	Peptidyl-tRNA hydrolase ICT1, mitochondrial	206	23630	10.09	0	Nucleoplasm;Mitochondrion	NA	Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.	NA	Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	17
+NX_Q14201	Protein BTG3	252	29116	9.12	0	NA	NA	Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.	NA	Belongs to the BTG family.	RNA degradation	PE1	21
+NX_Q14202	Zinc finger MYM-type protein 3	1370	152379	6.01	0	Nucleoplasm;Nucleus	NA	Plays a role in the regulation of cell morphology and cytoskeletal organization.	NA	NA	NA	PE1	X
+NX_Q14203	Dynactin subunit 1	1278	141695	5.61	0	Cytoplasm;Cell cortex;Centriole;Centrosome;Nucleus envelope;Spindle;Cytoskeleton	Amyotrophic lateral sclerosis;Perry syndrome;Neuronopathy, distal hereditary motor, 7B	Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020).	Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.;Phosphorylation by SLK at Thr-145, Thr-146 and Thr-147 targets DCTN1 to the centrosome. It is uncertain if SLK phosphorylates all three threonines or one or two of them. PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope, promotes its dissociation from microtubules during early mitosis and positively regulates nuclear envelope breakdown during prophase.;DCTN1 is phosphorylated by PRKACA	Belongs to the dynactin 150 kDa subunit family.	Vasopressin-regulated water reabsorption;Huntington's disease;Anchoring of the basal body to the plasma membrane;MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;XBP1(S) activates chaperone genes;Recruitment of NuMA to mitotic centrosomes;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;AURKA Activation by TPX2;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	2
+NX_Q14204	Cytoplasmic dynein 1 heavy chain 1	4646	532408	6.01	0	Cytoplasm;Cytosol;Centrosome;Cytoskeleton	Charcot-Marie-Tooth disease 2O;Mental retardation, autosomal dominant 13;Spinal muscular atrophy, lower extremity-predominant 1, autosomal dominant	Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074).	NA	Belongs to the dynein heavy chain family.	Phagosome;Vasopressin-regulated water reabsorption;Salmonella infection;Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Recruitment of NuMA to mitotic centrosomes;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;AURKA Activation by TPX2;Neutrophil degranulation;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	14
+NX_Q14206	Calcipressin-2	197	21997	5.84	0	Nucleoplasm;Mitochondrion	NA	Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.	NA	Belongs to the RCAN family.	NA	PE1	6
+NX_Q14207	Protein NPAT	1427	154290	5.63	0	Cajal body;Nucleoplasm;Nucleus	NA	Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.	Phosphorylated at Ser-775, Ser-779, Ser-1100, Thr-1270 and Thr-1350 by CCNE1/CDK2 at G1-S transition and until prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription. Also phosphorylated by CCNA1/CDK2 in vitro.	Belongs to the NPAT family.	NA	PE1	11
+NX_Q14209	Transcription factor E2F2	437	47506	4.75	0	Nucleus	NA	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.	Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.	Belongs to the E2F/DP family.	Cell cycle;HTLV-I infection;Pathways in cancer;Pancreatic cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Oxidative Stress Induced Senescence;CDC6 association with the ORC:origin complex;Oncogene Induced Senescence;Cyclin D associated events in G1	PE1	1
+NX_Q14210	Lymphocyte antigen 6D	128	13286	8.59	0	Cell membrane	NA	May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification.	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	8
+NX_Q14213	Interleukin-27 subunit beta	229	25396	9.41	0	Secreted	NA	Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.	NA	Belongs to the type I cytokine receptor family. Type 3 subfamily.	Interleukin-35 Signalling;Interleukin-27 signaling	PE1	19
+NX_Q14232	Translation initiation factor eIF-2B subunit alpha	305	33712	6.91	0	Cytosol	Leukodystrophy with vanishing white matter	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.	NA	Belongs to the eIF-2B alpha/beta/delta subunits family.	RNA transport;Recycling of eIF2:GDP	PE1	12
+NX_Q14236	Early lymphoid activation gene protein	149	17843	10.16	0	NA	NA	May function as an early signal that helps mediate the activation of T-cells.	NA	NA	NA	PE2	X
+NX_Q14240	Eukaryotic initiation factor 4A-II	407	46402	5.33	0	NA	NA	ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	NA	Belongs to the DEAD box helicase family. eIF4A subfamily.	RNA transport;ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Deadenylation of mRNA;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	PE1	3
+NX_Q14241	Elongin-A	798	89909	9.59	0	Cytosol;Nucleus speckle;Nucleus	NA	SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).	NA	NA	Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes	PE1	1
+NX_Q14242	P-selectin glycoprotein ligand 1	412	43201	4.35	1	Membrane	NA	A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.;(Microbial infection) Acts as a receptor for enterovirus 71.	Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for interaction with selectins and for functioning in leukocyte rolling. The modification containing the sialyl Lewis X glycan is on Thr-57. No sulfated O-glycans. Some N-glycosylation.;Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51, whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and leukocyte rolling.	NA	Cell adhesion molecules (CAMs);Staphylococcus aureus infection;Cell surface interactions at the vascular wall	PE1	12
+NX_Q14244	Ensconsin	749	84052	9.62	0	Basolateral cell membrane;Cytosol;Perinuclear region;Cytoskeleton	NA	Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.	The association with microtubules is regulated by phosphorylation during the cell cycle. During interphase only phosphorylated on serine. Phosphorylated on threonine in mitosis.	Belongs to the MAP7 family.	NA	PE1	6
+NX_Q14246	Adhesion G protein-coupled receptor E1	886	97683	6.42	7	Cell membrane	NA	Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.	NA	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	Class B/2 (Secretin family receptors)	PE1	19
+NX_Q14247	Src substrate cortactin	550	61586	5.24	0	Golgi apparatus;Dendritic spine;Cell cortex;Cell membrane;Cell junction;Podosome;Cell projection;Focal adhesion;Clathrin-coated pit;Lamellipodium;Ruffle;Cytoplasmic vesicle;Cytosol;Dendrite;Cytoskeleton	NA	Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).	Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.;CTTN is phosphorylated by PKN2 (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254);CTTN is phosphorylated by FER	NA	Tight junction;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;RHO GTPases activate PAKs;Clathrin-mediated endocytosis	PE1	11
+NX_Q14249	Endonuclease G, mitochondrial	297	32620	9.53	0	Mitochondrion	NA	Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).	NA	Belongs to the DNA/RNA non-specific endonuclease family.	Apoptosis	PE1	9
+NX_Q14254	Flotillin-2	428	47064	5.19	0	Cell membrane;Membrane;Endosome;Caveola;Cytoplasmic vesicle	NA	May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.	ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.	Belongs to the band 7/mec-2 family. Flotillin subfamily.	Insulin signaling pathway;Synaptic adhesion-like molecules	PE1	17
+NX_Q14257	Reticulocalbin-2	317	36876	4.26	0	Endoplasmic reticulum;Endoplasmic reticulum lumen	NA	Not known. Binds calcium.	NA	Belongs to the CREC family.	NA	PE1	15
+NX_Q14258	E3 ubiquitin/ISG15 ligase TRIM25	630	70973	8.44	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1 (PubMed:17392790, PubMed:30193849). Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).	Auto-ISGylated.	NA	Protein modification; protein ubiquitination.;RIG-I-like receptor signaling pathway;Influenza A;ISG15 antiviral mechanism;Interferon gamma signaling;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;Termination of translesion DNA synthesis;TRAF3-dependent IRF activation pathway;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Ovarian tumor domain proteases	PE1	17
+NX_Q14264	Endogenous retrovirus group 3 member 1 Env polyprotein	604	67942	6.84	0	Cytoplasmic vesicle;Virion	NA	SU mediates receptor recognition.;TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro.	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins (By similarity). Has been mainly detected in vivo as an 65 kDa unprocessed polyprotein precursor.;The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity).	Belongs to the gamma type-C retroviral envelope protein family. HERV class-I R env subfamily.	NA	PE1	7
+NX_Q14289	Protein-tyrosine kinase 2-beta	1009	115875	5.91	0	Cytoplasm;Cell cortex;Cell membrane;Focal adhesion;Lamellipodium;Cytosol;Perinuclear region;Nucleus	NA	Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2.	Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration; this activation is indirect and may be mediated by production of reactive oxygen species (ROS). Tyr-402 is the major autophosphorylation site, but other kinases can also phosphorylate Tyr-402. Autophosphorylation occurs in trans, i.e. One subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-402 promotes interaction with SRC and SRC family members, leading to phosphorylation at Tyr-579; Tyr-580 and Tyr-881. Phosphorylation at Tyr-881 is important for interaction with GRB2. Phosphorylated on tyrosine residues upon activation of FGR and PKC. Recruitment by NPHP1 to cell matrix adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha-lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity. Phosphorylation by MYLK promotes ITGB2 activation and is thus essential to trigger neutrophil transmigration during lung injury. Dephosphorylated by PTPN12.;PTK2B is phosphorylated by MYLK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.	Calcium signaling pathway;Chemokine signaling pathway;Natural killer cell mediated cytotoxicity;Leukocyte transendothelial migration;GnRH signaling pathway;VEGFA-VEGFR2 Pathway;Signal regulatory protein family interactions;Interleukin-2 signaling	PE1	8
+NX_Q14296	Fas-activated serine/threonine kinase	549	61104	9.96	0	Mitochondrion matrix;Nucleus speckle;Mitochondrion	NA	Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.;Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.	Autophosphorylated on serine/threonine residues. Activated by dephosphorylation.	Belongs to the FAST protein kinase family.	NA	PE1	7
+NX_Q14314	Fibroleukin	439	50229	7.09	0	Secreted	NA	May play a role in physiologic lymphocyte functions at mucosal sites.	NA	NA	Neutrophil degranulation	PE1	7
+NX_Q14315	Filamin-C	2725	291022	5.65	0	Cytoplasm;Cell membrane;Membrane;Cytosol;Z line;Cytoskeleton	Myopathy, distal, 4;Myopathy, myofibrillar, 5;Cardiomyopathy, familial restrictive 5;Cardiomyopathy, familial hypertrophic 26	Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.	Ubiquitinated by FBXL22, leading to proteasomal degradation.	Belongs to the filamin family.	MAPK signaling pathway;Focal adhesion;Salmonella infection;Cell-extracellular matrix interactions	PE1	7
+NX_Q14318	Peptidyl-prolyl cis-trans isomerase FKBP8	412	44562	4.78	1	Mitochondrion membrane;Endoplasmic reticulum;Cytosol;Mitochondrion	NA	Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	NA	Ub-specific processing proteases	PE1	19
+NX_Q14320	Protein FAM50A	339	40242	6.39	0	Nucleoplasm;Nucleus	NA	May be a DNA-binding protein or transcriptional factor.	NA	Belongs to the FAM50 family.	NA	PE1	X
+NX_Q14324	Myosin-binding protein C, fast-type	1141	128072	7.44	0	NA	NA	Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.	NA	Belongs to the immunoglobulin superfamily. MyBP family.	Striated Muscle Contraction	PE1	19
+NX_Q14330	N-arachidonyl glycine receptor	331	38134	9.38	7	Cytoplasmic vesicle membrane;Cell membrane	NA	Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937).	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Class A/1 (Rhodopsin-like receptors)	PE1	13
+NX_Q14331	Protein FRG1	258	29172	9.1	0	Cajal body;Cytoplasm;Z line;Nucleolus	Facioscapulohumeral muscular dystrophy 1	Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B.	NA	Belongs to the FRG1 family.	NA	PE1	4
+NX_Q14332	Frizzled-2	565	63554	8.47	7	Cell membrane;Cell junction;Membrane;Nucleoplasm;Nucleus	Omodysplasia 2	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.	Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Asymmetric localization of PCP proteins;Class B/2 (Secretin family receptors);TCF dependent signaling in response to WNT;Ca2+ pathway;Disassembly of the destruction complex and recruitment of AXIN to the membrane;WNT5A-dependent internalization of FZD2, FZD5 and ROR2	PE1	17
+NX_Q14344	Guanine nucleotide-binding protein subunit alpha-13	377	44050	8.12	0	Cytoplasm;Cell membrane;Melanosome;Cytosol;Nucleus	NA	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).	Palmitoylation is critical for proper membrane localization and signaling.;Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation.;GNA13 is phosphorylated by ITK (Phosphotyrosine:PTM-0255)	Belongs to the G-alpha family. G(12) subfamily.	Vascular smooth muscle contraction;Long-term depression;Regulation of actin cytoskeleton;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs)	PE1	17
+NX_Q14353	Guanidinoacetate N-methyltransferase	236	26318	5.74	0	NA	Cerebral creatine deficiency syndrome 2	Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor (PubMed:26003046, PubMed:24415674, PubMed:26319512). Important in nervous system development (PubMed:24415674).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.	Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2.;Glycine, serine and threonine metabolism;Arginine and proline metabolism;Metabolic pathways;Creatine metabolism;Transcriptional Regulation by MECP2	PE1	19
+NX_Q14376	UDP-glucose 4-epimerase	348	38282	6.26	0	Nucleoplasm;Cytosol;Cell membrane	Epimerase-deficiency galactosemia	Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.	NA	Belongs to the NAD(P)-dependent epimerase/dehydratase family.	Carbohydrate metabolism; galactose metabolism.;Galactose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Defective GALE can cause Epimerase-deficiency galactosemia (EDG);Galactose catabolism	PE1	1
+NX_Q14390	Glutathione hydrolase light chain 2	218	23661	5.11	0	NA	NA	NA	NA	Belongs to the gamma-glutamyltransferase family.	NA	PE2	22
+NX_Q14392	Transforming growth factor beta activator LRRC32	662	71979	5.73	1	Cell surface;Nucleoplasm;Cell membrane	NA	Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).	NA	Belongs to the LRRC32/LRRC33 family.	NA	PE1	11
+NX_Q14393	Growth arrest-specific protein 6	678	74925	5.46	0	Cytosol;Centriolar satellite;Secreted	NA	Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.;(Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).	Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.;Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.	NA	Cell surface interactions at the vascular wall;Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins;Post-translational protein phosphorylation	PE1	13
+NX_Q14397	Glucokinase regulatory protein	625	68685	6.24	0	Cytoplasm;Mitochondrion;Nucleus;Cytoskeleton	NA	Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961).	NA	Belongs to the GCKR family.	Regulation of Glucokinase by Glucokinase Regulatory Protein;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	PE1	2
+NX_Q14406	Chorionic somatomammotropin hormone-like 1	222	25391	5.56	0	Secreted	NA	May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation.	NA	Belongs to the somatotropin/prolactin family.	NA	PE1	17
+NX_Q14409	Glycerol kinase 3	553	60598	6	0	Mitochondrion outer membrane;Cytoplasm	NA	Key enzyme in the regulation of glycerol uptake and metabolism.	NA	Belongs to the FGGY kinase family.	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.;Triglyceride biosynthesis	PE1	4
+NX_Q14410	Glycerol kinase 2	553	60594	5.57	0	Mitochondrion outer membrane;Cytoplasm	NA	Key enzyme in the regulation of glycerol uptake and metabolism.	NA	Belongs to the FGGY kinase family.	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.;Glycerolipid metabolism;Metabolic pathways;PPAR signaling pathway;Triglyceride biosynthesis	PE1	4
+NX_Q14416	Metabotropic glutamate receptor 2	872	95568	8.5	7	Dendrite;Synapse;Cell membrane	NA	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.	NA	Belongs to the G-protein coupled receptor 3 family.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	3
+NX_Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	1141	124979	5.66	6	Membrane;Cell membrane	Hypertension and brachydactyly syndrome	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.	Purine metabolism;Insulin signaling pathway;Progesterone-mediated oocyte maturation;G alpha (s) signalling events	PE1	12
+NX_Q14435	Polypeptide N-acetylgalactosaminyltransferase 3	633	72610	8.2	1	Golgi stack membrane;Golgi apparatus	Tumoral calcinosis, hyperphosphatemic, familial, 1	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins;FGFR3c ligand binding and activation;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	PE1	2
+NX_Q14439	G-protein coupled receptor 176	515	56998	8.81	7	Cell membrane	NA	Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (s) signalling events	PE1	15
+NX_Q14442	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H	188	21081	6.29	0	Cytoplasm	Glycosylphosphatidylinositol biosynthesis defect 17	Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.	NA	Belongs to the PIGH family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	14
+NX_Q14444	Caprin-1	709	78366	5.14	0	Cytoplasm;Cytosol;Dendrite	NA	May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.	O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.	Belongs to the caprin family.	NA	PE1	11
+NX_Q14449	Growth factor receptor-bound protein 14	540	60988	8.56	0	Nucleoplasm;Cytoplasm;Cytosol;Endosome membrane	NA	Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.	Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2.;GRB14 is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the GRB7/10/14 family.	Tie2 Signaling	PE1	2
+NX_Q14451	Growth factor receptor-bound protein 7	532	59681	8.82	0	Cytoplasm;Cell membrane;Focal adhesion;Cell projection;Cytosol;Cytoplasmic granule	NA	Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).	Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases.;GRB7 is phosphorylated by RET (Phosphotyrosine:PTM-0255);GRB7 is phosphorylated by EPHB1 (Phosphotyrosine:PTM-0255)	Belongs to the GRB7/10/14 family.	Signaling by SCF-KIT;Tie2 Signaling;GRB7 events in ERBB2 signaling;Downstream signal transduction;RET signaling	PE1	17
+NX_Q14457	Beclin-1	450	51896	4.83	0	Cytoplasm;Endoplasmic reticulum membrane;Mitochondrion;Endosome membrane;trans-Golgi network membrane;Endosome;Autophagosome;Mitochondrion membrane;Nucleus	NA	Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.;Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.	Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy (PubMed:19180116). In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy (PubMed:23878393).;Polyubiquitinated by NEDD4, both with 'Lys-11'- and 'Lys-63'-linkages (PubMed:21936852). 'Lys-11'-linked polyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted (PubMed:21936852). Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). Polyubiquitinated at Lys-402 with 'Lys-48'-linkages (PubMed:28445460). 'Lys-48'-linked polyubiquitination of Lys-402 leads to degradation (PubMed:28445460). Deubiquitinated by ATXN3, leading to stabilization (PubMed:28445460).;Proteolytically processed by caspases including CASP8 and CASP3; the C-terminal fragments lack autophagy-inducing capacity and are proposed to induce apoptosis. Thus the cleavage is proposed to be an determinant to switch from autophagy to apoptosis pathways affecting cellular homeostasis including viral infections and survival of tumor cells.	Belongs to the beclin family.	Regulation of autophagy;Macroautophagy;Ub-specific processing proteases	PE1	17
+NX_Q14469	Transcription factor HES-1	280	29541	9.66	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.	NA	NA	Fanconi anemia pathway;Notch signaling pathway;Maturity onset diabetes of the young;NOTCH2 intracellular domain regulates transcription;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;RUNX3 regulates NOTCH signaling;RUNX2 regulates osteoblast differentiation;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE1	3
+NX_Q14493	Histone RNA hairpin-binding protein	270	31286	7.06	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs.	Phosphorylated on Thr-61 and Thr-62 in the S-phase. Phosphorylation of Thr-62 by CDK1 primes phosphorylation of Thr-61 by CK2. Phosphorylation of Thr-62 is required for its degradation by the proteasome at the end of the S phase. Its degradation is not required for histone mRNA degradation at the end of the S phase. All the phosphorylated forms detected are present in the cytoplasm. Both unphosphorylated and phosphorylated forms bind the stem-loop structure of histone mRNAs. Phosphorylation at Thr-171 increases affinity for histone mRNAs.	Belongs to the SLBP family.	Transport of the SLBP Dependant Mature mRNA;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	4
+NX_Q14494	Endoplasmic reticulum membrane sensor NFE2L1	772	84704	4.52	1	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane;Nucleus	NA	Endoplasmic reticulum membrane sensor NFE2L1: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482).;Transcription factor NRF1: CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses (PubMed:8932385, PubMed:9421508). Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response (PubMed:8932385, PubMed:9421508). Activates or represses expression of target genes, depending on the context (PubMed:8932385, PubMed:9421508). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess, such as CD36 (By similarity). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes, such as GCLC, GCLM, GSS, MT1 and MT2 (By similarity). Plays an essential role during fetal liver hematopoiesis: probably has a protective function against oxidative stress and is involved in lipid homeostasis in the liver (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (PubMed:20932482). Also involved in regulating glucose flux (By similarity). Together with CEBPB; represses expression of DSPP during odontoblast differentiation (PubMed:15308669). In response to ascorbic acid induction, activates expression of SP7/Osterix in osteoblasts.	Endoplasmic reticulum membrane sensor NFE2L1: Cleaved at Leu-104 by the aspartyl protease DDI2 following retrotranslocation, releasing the protein from the endoplasmic reticulum membrane and forming the transcription factor NRF1 that translocates into the nucleus (PubMed:24448410, PubMed:27676297, PubMed:27676298, PubMed:27528193). Ubiquitination is prerequisite for cleavage by aspartyl protease DDI2 (PubMed:27676298).;Endoplasmic reticulum membrane sensor NFE2L1: Ubiquitinated by the SCF(FBXW7) complex and SYVN1/HRD1, leading to its degradation by the proteasome (PubMed:20932482). Ubiquitinated during retrotranslocation to the cytosolic side of the membrane: ubiquitination does not lead to degradation and is required for processing by the aspartyl protease DDI2 and subsequent release from the endoplasmic reticulum membrane (PubMed:24998528, PubMed:27676298).;Transcription factor NRF1: Ubiquitinated by the SCF(BTRC) complex in the nucleus, leading to its degradation by the proteasome.;Transcription factor NRF1: Phosphorylation by CK2 at Ser-528 inhibits transcription factor activity, possibly by affecting DNA-binding activity (By similarity). Phosphorylation at Ser-599 is required for interaction with CEBPB (PubMed:15308669).;Endoplasmic reticulum membrane sensor NFE2L1: N-glycosylated in normal conditions, when it has a single-pass type II membrane protein topology, with the DNA-binding domain facing the endoplasmic reticulum lumen (PubMed:20932482, PubMed:24998528, PubMed:24448410, PubMed:27528193). Deglycosylated during retrotranslocation to the cytosolic side of the membrane, to have a single-pass type III membrane protein topology with the major part of the protein facing the cytosol (PubMed:20932482, PubMed:24998528, PubMed:24448410).	Belongs to the bZIP family. CNC subfamily.	NA	PE1	17
+NX_Q14498	RNA-binding protein 39	530	59380	10.1	0	Nucleus speckle;Centriolar satellite;Nucleoplasm;Nucleus;Cytoskeleton	NA	Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process.	NA	Belongs to the splicing factor SR family.	NA	PE1	20
+NX_Q14500	ATP-sensitive inward rectifier potassium channel 12	433	49001	5.63	2	Membrane;Cell membrane	NA	Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.	NA	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.	Cholinergic synapse;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Classical Kir channels;Phase 4 - resting membrane potential	PE1	17
+NX_Q14507	Epididymal secretory protein E3-alpha	147	17646	8.64	0	Secreted	NA	Possible function in sperm maturation.	NA	NA	NA	PE1	14
+NX_Q14508	WAP four-disulfide core domain protein 2	124	12993	4.69	0	Secreted	NA	Broad range protease inhibitor.	NA	NA	NA	PE1	20
+NX_Q14511	Enhancer of filamentation 1	834	92861	6.23	0	Golgi apparatus;Cytoplasm;Cell cortex;Cell membrane;Focal adhesion;Nucleoplasm;Lamellipodium;Cytosol;Spindle;Nucleus	NA	Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.	Cell cycle-regulated processing produces four isoforms: p115, p105, p65, and p55.;PTK2/FAK1 phosphorylates the protein at the YDYVHL motif (conserved among all cas proteins). The SRC family kinases (FYN, SRC, LCK and CRK) are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Ligation of either integrin beta-1 or B-cell antigen receptor on tonsillar B-cells and B-cell lines promotes tyrosine phosphorylation and both integrin and BCR-mediated tyrosine phosphorylation requires an intact actin network. In fibroblasts transformation with oncogene v-ABL results in an increase in tyrosine phosphorylation. Transiently phosphorylated following CD3 cross-linking and this phosphorylated form binds to CRK and C3G. A mutant lacking the SH3 domain is phosphorylated upon CD3 cross-linking but not upon integrin beta-1 cross-linking. Tyrosine phosphorylation occurs upon stimulation of the G-protein coupled C1a calcitonin receptor. Calcitonin-stimulated tyrosine phosphorylation is mediated by calcium- and protein kinase C-dependent mechanisms and requires the integrity of the actin cytoskeleton. Phosphorylation at Ser-369 induces proteasomal degradation.	Belongs to the CAS family.	NA	PE1	6
+NX_Q14512	Fibroblast growth factor-binding protein 1	234	26264	9.28	0	Extracellular space;Cell membrane	NA	Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.	NA	Belongs to the fibroblast growth factor-binding protein family.	FGFR2b ligand binding and activation	PE1	4
+NX_Q14515	SPARC-like protein 1	664	75208	4.71	0	Extracellular matrix	NA	NA	N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.	Belongs to the SPARC family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	4
+NX_Q14517	Protocadherin Fat 1	4588	506273	4.85	1	Perinuclear region;Nucleus;Cell membrane	NA	Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.	Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.	NA	NA	PE1	4
+NX_Q14520	Hyaluronan-binding protein 2	560	62672	6.09	0	Secreted	Thyroid cancer, non-medullary, 5	Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (PubMed:8827452, PubMed:10754382, PubMed:11217080). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560).	Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments (By similarity).	Belongs to the peptidase S1 family.	NA	PE1	10
+NX_Q14524	Sodium channel protein type 5 subunit alpha	2016	226940	5.34	24	T-tubule;Cell membrane;Nucleolus;Nucleoplasm;Perinuclear region	Progressive familial heart block 1A;Familial paroxysmal ventricular fibrillation 1;Atrial standstill 1;Atrial fibrillation, familial, 10;Brugada syndrome 1;Long QT syndrome 3;Sick sinus syndrome 1;Sudden infant death syndrome;Cardiomyopathy, dilated 1E	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1309946, PubMed:21447824, PubMed:25370050, PubMed:23420830, PubMed:23085483, PubMed:26279430, PubMed:26392562, PubMed:26776555). It is a tetrodotoxin-resistant Na(+) channel isoform (PubMed:1309946). This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (PubMed:19074138).	Ubiquitinated by NEDD4L; which promotes its endocytosis. Does not seem to be ubiquitinated by NEDD4 or WWP2.;Phosphorylation at Ser-1503 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents (Probable). Regulated through phosphorylation by CaMK2D (By similarity).;Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 868) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.5/SCN5A subfamily.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	3
+NX_Q14525	Keratin, type I cuticular Ha3-II	404	46214	4.81	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q14526	Hypermethylated in cancer 1 protein	733	76508	6.38	0	Nucleus	NA	Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.	Sumoylated on Lys-333 by a PIAS family member, which enhances interaction with MTA1, positively regulates transcriptional repression activity and is enhanced by HDAC4.;Acetylated on several residues, including Lys-333. Lys-333 is deacetylated by SIRT1.	Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.	SUMOylation of transcription factors	PE1	17
+NX_Q14527	Helicase-like transcription factor	1009	113929	8.82	0	Nucleus;Cytoplasm;Nucleoplasm;Nucleolus	NA	Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.	NA	Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily.	Protein modification; protein ubiquitination.;E3 ubiquitin ligases ubiquitinate target proteins	PE1	3
+NX_Q14532	Keratin, type I cuticular Ha2	448	50343	4.78	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q14533	Keratin, type II cuticular Hb1	505	54928	5.4	0	NA	Monilethrix	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q14534	Squalene monooxygenase	574	63923	8.8	0	Microsome membrane;Cytoplasmic vesicle;Cytosol;Endoplasmic reticulum membrane	NA	Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.	Ubiquitinated by MARCH6 in response to high cholesterol levels in intracellular membranes, leading to proteasomal degradation.	Belongs to the squalene monooxygenase family.	Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.;Steroid biosynthesis;Metabolic pathways;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	8
+NX_Q14541	Hepatocyte nuclear factor 4-gamma	408	45877	8.68	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor. Has a lower transcription activation potential than HNF4-alpha.	NA	Belongs to the nuclear hormone receptor family. NR2 subfamily.	Maturity onset diabetes of the young;Regulation of gene expression in beta cells;Nuclear Receptor transcription pathway	PE1	8
+NX_Q14542	Equilibrative nucleoside transporter 2	456	50113	5.76	11	Basolateral cell membrane;Nucleoplasm;Nucleus membrane	NA	Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.	NA	Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	PE1	11
+NX_Q14549	Homeobox protein GBX-1	363	37629	7.04	0	Nucleus	NA	NA	NA	NA	NA	PE1	7
+NX_Q14554	Protein disulfide-isomerase A5	519	59594	8.08	0	Golgi apparatus;Cell membrane;Nucleolus;Nucleoplasm;Endoplasmic reticulum lumen	NA	NA	NA	Belongs to the protein disulfide isomerase family.	XBP1(S) activates chaperone genes	PE1	3
+NX_Q14558	Phosphoribosyl pyrophosphate synthase-associated protein 1	356	39394	6.73	0	Cytosol	NA	Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.	NA	Belongs to the ribose-phosphate pyrophosphokinase family.	NA	PE1	17
+NX_Q14562	ATP-dependent RNA helicase DHX8	1220	139315	8.54	0	Nucleoplasm;Nucleus	NA	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946).	NA	Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.	Spliceosome	PE1	17
+NX_Q14563	Semaphorin-3A	771	88889	7.05	0	Nucleoplasm;Secreted;Cytoplasmic vesicle	Hypogonadotropic hypogonadism 16 with or without anosmia	Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.	NA	Belongs to the semaphorin family.	Axon guidance;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Sema3A PAK dependent Axon repulsion;CRMPs in Sema3A signaling	PE1	7
+NX_Q14565	Meiotic recombination protein DMC1/LIM15 homolog	340	37681	5.62	0	Nucleoplasm;Nucleus;Chromosome	NA	May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.	NA	Belongs to the RecA family. DMC1 subfamily.	Meiotic recombination	PE1	22
+NX_Q14566	DNA replication licensing factor MCM6	821	92889	5.29	0	Nucleoplasm;Nucleus	NA	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.	O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.	Belongs to the MCM family.	DNA replication;Cell cycle;Orc1 removal from chromatin;Activation of ATR in response to replication stress;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;Unwinding of DNA;Switching of origins to a post-replicative state	PE1	2
+NX_Q14568	Heat shock protein HSP 90-alpha A2	343	39365	4.57	0	Cytoplasm	NA	Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.	NA	Belongs to the heat shock protein 90 family.	NA	PE1	11
+NX_Q14571	Inositol 1,4,5-trisphosphate receptor type 2	2701	308064	6.01	6	Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum membrane	Anhidrosis, isolated, with normal sweat glands	Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).	Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.	Belongs to the InsP3 receptor family.	Calcium signaling pathway;Phosphatidylinositol signaling system;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;Dopaminergic synapse;Long-term depression;GnRH signaling pathway;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Alzheimer's disease;Effects of PIP2 hydrolysis;FCERI mediated Ca+2 mobilization;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Ca2+ pathway;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;VEGFR2 mediated cell proliferation;Regulation of insulin secretion;PLC beta mediated events;CLEC7A (Dectin-1) induces NFAT activation;Elevation of cytosolic Ca2+ levels;DAG and IP3 signaling;Ion homeostasis	PE1	12
+NX_Q14573	Inositol 1,4,5-trisphosphate receptor type 3	2671	304106	6.05	6	Cytoplasmic vesicle;Endoplasmic reticulum membrane	NA	Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.	Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity).	Belongs to the InsP3 receptor family.	Calcium signaling pathway;Phosphatidylinositol signaling system;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;Dopaminergic synapse;Long-term depression;Taste transduction;GnRH signaling pathway;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Alzheimer's disease;Effects of PIP2 hydrolysis;FCERI mediated Ca+2 mobilization;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Ca2+ pathway;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;VEGFR2 mediated cell proliferation;Regulation of insulin secretion;PLC beta mediated events;CLEC7A (Dectin-1) induces NFAT activation;Elevation of cytosolic Ca2+ levels;DAG and IP3 signaling;Ion homeostasis	PE1	6
+NX_Q14574	Desmocollin-3	896	99969	5.77	1	Cell junction;Desmosome;Cell membrane	Hypotrichosis and recurrent skin vesicles	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.	NA	NA	Formation of the cornified envelope;Keratinization	PE1	18
+NX_Q14576	ELAV-like protein 3	367	39547	9.33	0	NA	NA	RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity).	NA	Belongs to the RRM elav family.	NA	PE1	19
+NX_Q14582	Max dimerization protein 4	209	23528	6.46	0	Cytosol;Nucleus	NA	Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).	NA	NA	Nuclear signaling by ERBB4	PE1	4
+NX_Q14584	Zinc finger protein 266	549	62116	8.93	0	Cytoplasmic vesicle;Nucleoplasm;Cytoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q14585	Zinc finger protein 345	488	55383	8.7	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q14586	Zinc finger protein 267	743	87376	9.14	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_Q14587	Zinc finger protein 268	947	108374	9.14	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.;Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	12
+NX_Q14588	Zinc finger protein 234	700	80560	8.96	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q14590	Zinc finger protein 235	738	83977	8.91	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q14592	Zinc finger protein 460	562	63665	6.55	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q14593	Zinc finger protein 273	569	64971	9.62	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q14596	Next to BRCA1 gene 1 protein	966	107413	5.03	0	Cytoplasm;M line;Nucleoplasm;Autophagosome;Lysosome;Cytoplasmic vesicle;Nucleus	NA	Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.	NA	NA	NA	PE1	17
+NX_Q14602	Putative DNA-binding protein inhibitor ID-2B	36	4055	10.27	0	NA	NA	NA	NA	NA	NA	PE5	3
+NX_Q14623	Indian hedgehog protein	411	45251	8.98	0	Extracellular space;Cell membrane	Acrocapitofemoral dysplasia;Brachydactyly A1	Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).	Cholesterylation is required for N-product targeting to lipid rafts and multimerization.;Palmitoylated. N-palmitoylation is required for N-product multimerization and full activity.;The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity (By similarity).	Belongs to the hedgehog family.	Hedgehog signaling pathway;Hedgehog ligand biogenesis;Hedgehog 'on' state;Class B/2 (Secretin family receptors);Activation of SMO;Release of Hh-Np from the secreting cell;Ligand-receptor interactions;HHAT G278V abrogates palmitoylation of Hh-Np;RUNX2 regulates chondrocyte maturation	PE1	2
+NX_Q14624	Inter-alpha-trypsin inhibitor heavy chain H4	930	103357	6.51	0	Cytoplasmic vesicle;Secreted	NA	Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.	N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma.;Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment.	Belongs to the ITIH family.	Platelet degranulation	PE1	3
+NX_Q14626	Interleukin-11 receptor subunit alpha	422	45222	8.03	1	Membrane	Craniosynostosis and dental anomalies	Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.	NA	Belongs to the type I cytokine receptor family. Type 3 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;IL-6-type cytokine receptor ligand interactions	PE1	9
+NX_Q14627	Interleukin-13 receptor subunit alpha-2	380	44176	4.84	1	Cell membrane;Cell junction;Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).	NA	Belongs to the type I cytokine receptor family. Type 5 subfamily.	Jak-STAT signaling pathway;Interleukin-4 and Interleukin-13 signaling	PE1	X
+NX_Q14641	Early placenta insulin-like peptide	139	15445	9.28	0	Secreted	NA	May play an important role in trophoblast development and in the regulation of bone formation.	NA	Belongs to the insulin family.	NA	PE1	9
+NX_Q14642	Inositol polyphosphate-5-phosphatase A	412	47820	6.58	0	Endoplasmic reticulum;Cell membrane	NA	Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.	NA	Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of IP2, IP, and Ins in the cytosol	PE1	10
+NX_Q14643	Inositol 1,4,5-trisphosphate receptor type 1	2758	313929	5.71	6	Cytoplasmic vesicle;Secretory vesicle membrane;Endoplasmic reticulum membrane;Perinuclear region	Spinocerebellar ataxia 15;Spinocerebellar ataxia 29;Gillespie syndrome	Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).	Palmitoylated by ZDHHC6 in immune cells, leading to regulate ITPR1 stability and function.;Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked (By similarity).;Phosphorylated on tyrosine residues.;Phosphorylated by cAMP kinase (PKA). Phosphorylation prevents the ligand-induced opening of the calcium channels. Phosphorylation by PKA increases the interaction with inositol 1,4,5-trisphosphate and decreases the interaction with AHCYL1.	Belongs to the InsP3 receptor family.	Calcium signaling pathway;Phosphatidylinositol signaling system;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;Dopaminergic synapse;Long-term depression;GnRH signaling pathway;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Alzheimer's disease;Huntington's disease;Effects of PIP2 hydrolysis;FCERI mediated Ca+2 mobilization;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Ca2+ pathway;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Role of phospholipids in phagocytosis;VEGFR2 mediated cell proliferation;Regulation of insulin secretion;PLC beta mediated events;cGMP effects;CLEC7A (Dectin-1) induces NFAT activation;Elevation of cytosolic Ca2+ levels;DAG and IP3 signaling;Ion homeostasis	PE1	3
+NX_Q14644	Ras GTPase-activating protein 3	834	95699	6.76	0	Cell membrane	NA	Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.	NA	NA	Regulation of RAS by GAPs;Signaling by RAS mutants	PE1	13
+NX_Q14651	Plastin-1	629	70253	5.28	0	Cytoplasm	NA	Actin-bundling protein in the absence of calcium.	Phosphorylated.	NA	NA	PE1	3
+NX_Q14653	Interferon regulatory factor 3	427	47219	5.17	0	Cytoplasm;Cytosol;Nucleus	Encephalopathy, acute, infection-induced, Herpes-specific, 7	Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:25636800, PubMed:27302953). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591).	(Microbial infection) Phosphorylation and subsequent activation of IRF3 is inhibited by vaccinia virus protein E3.;Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitination involves TRIM21 leading to proteasomal degradation.;ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by disrupting PIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation.;Constitutively phosphorylated on many Ser/Thr residues (PubMed:22394562, PubMed:23478265, PubMed:23746807). Activated following phosphorylation by TBK1 and IKBKE (PubMed:23478265, PubMed:23746807, PubMed:25636800). Innate adapter protein MAVS, TMEM173/STING or TICAM1 are first activated by viral RNA, cytosolic DNA, and bacterial lipopolysaccharide (LPS), respectively, leading to activation of the kinases TBK1 and IKBKE (PubMed:25636800). These kinases then phosphorylate the adapter proteins on the pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs (PubMed:25636800).;IRF3 is phosphorylated by IKBKB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the IRF family.	Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Pertussis;Hepatitis C;Measles;Influenza A;Herpes simplex infection;ISG15 antiviral mechanism;Interferon gamma signaling;Interferon alpha/beta signaling;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN;IRF3 mediated activation of type 1 IFN;TRAF3-dependent IRF activation pathway;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;TICAM1-dependent activation of IRF3/IRF7	PE1	19
+NX_Q14654	ATP-sensitive inward rectifier potassium channel 11	390	43541	8.15	2	Membrane	Familial hyperinsulinemic hypoglycemia 2;Maturity-onset diabetes of the young 13;Diabetes mellitus, permanent neonatal;Transient neonatal diabetes mellitus 3	This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.	Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.	ABC-family proteins mediated transport;Regulation of insulin secretion;ATP sensitive Potassium channels;Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia;Ion homeostasis;Defective ABCC8 can cause hypoglycemias and hyperglycemias	PE1	11
+NX_Q14656	Transmembrane protein 187	261	29148	9.05	6	Membrane;Golgi apparatus;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	X
+NX_Q14657	EKC/KEOPS complex subunit LAGE3	143	14804	8.88	0	Cytoplasm;Nucleoplasm;Nucleus	Galloway-Mowat syndrome 2, X-linked	Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.	NA	Belongs to the CTAG/PCC1 family.	tRNA modification in the nucleus and cytosol	PE1	X
+NX_Q14667	Protein KIAA0100	2235	253700	6.71	0	Cytosol;Nucleus speckle;Secreted	NA	May be involved in membrane trafficking.	NA	Belongs to the SABRE family.	NA	PE1	17
+NX_Q14669	E3 ubiquitin-protein ligase TRIP12	1992	220434	8.76	0	Nucleoplasm;Nucleus speckle	Mental retardation, autosomal dominant 49	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744).	NA	Belongs to the UPL family. K-HECT subfamily.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	2
+NX_Q14671	Pumilio homolog 1	1186	126473	6.35	0	Cytoplasm;Nucleoplasm;P-body;Cytosol;Cytoplasmic granule	Spinocerebellar ataxia 47	Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:21572425, PubMed:18328718, PubMed:21653694, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233).	Phosphorylation at Ser-714 promotes RNA-binding activity. Following growth factor stimulation phosphorylated at Ser-714, promoting binding to the 3'-UTR of CDKN1B/p27 mRNA.	NA	Golgi Associated Vesicle Biogenesis	PE1	1
+NX_Q14674	Separin	2120	233175	7.65	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.	Phosphorylated by CDK1. There are 8 Ser/Thr phosphorylation sites. Among them, Ser-1126 phosphorylation is the major site, which conducts to the enzyme inactivation.;Autocleaves. This function, which is not essential for its protease activity, is unknown.	NA	Cell cycle;Oocyte meiosis;Separation of Sister Chromatids	PE1	12
+NX_Q14676	Mediator of DNA damage checkpoint protein 1	2089	226666	5.35	0	Nucleoplasm;Nucleus;Chromosome	NA	Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.	Sumoylation at Lys-1840 by PIAS4 following DNA damage promotes ubiquitin-mediated degradation.;Ubiquitinated by RNF4, leading to proteasomal degradation; undergoes 'Lys-48'-linked polyubiquitination.;Phosphorylated upon exposure to ionizing radiation (IR), ultraviolet radiation (UV), and hydroxyurea (HU). Phosphorylation in response to IR requires ATM, NBN, and possibly CHEK2. Also phosphorylated during the G2/M phase of the cell cycle and during activation of the mitotic spindle checkpoint. Phosphorylation at Thr-4 by ATM stabilizes and enhances homodimerization via the FHA domain.;MDC1 is phosphorylated by MAPK3	NA	SUMOylation of DNA damage response and repair proteins;G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);TP53 Regulates Transcription of DNA Repair Genes	PE1	6
+NX_Q14677	Clathrin interactor 1	625	68259	6.01	0	Cytoplasm;Clathrin-coated vesicle;Membrane;Nucleoplasm;Cytoplasmic vesicle;Perinuclear region	NA	Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.	CLINT1 is phosphorylated by MAPK3	Belongs to the epsin family.	Golgi Associated Vesicle Biogenesis	PE1	5
+NX_Q14678	KN motif and ankyrin repeat domain-containing protein 1	1352	147289	5.18	0	Ruffle membrane;Cytoplasm;Nucleus;Cell membrane	Cerebral palsy, spastic quadriplegic 2	Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration (PubMed:25961457). Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1 (PubMed:25961457). Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways (PubMed:25961457).	NA	NA	Estrogen-dependent gene expression	PE1	9
+NX_Q14679	Tubulin polyglutamylase TTLL4	1199	133378	9.04	0	Mitochondrion;Cilium;Cilium basal body	NA	Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase: generates monoglutamylation of CGAS, leading to impair the nucleotidyltransferase activity of CGAS.	NA	Belongs to the tubulin--tyrosine ligase family.	Carboxyterminal post-translational modifications of tubulin	PE1	2
+NX_Q14680	Maternal embryonic leucine zipper kinase	651	74642	8.92	0	Cell membrane	NA	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.	Autophosphorylated: autophosphorylation of the T-loop at Thr-167 and Ser-171 is required for activation. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8 (Probable).	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	NA	PE1	9
+NX_Q14681	BTB/POZ domain-containing protein KCTD2	263	28527	5.21	0	NA	NA	NA	NA	NA	NA	PE1	17
+NX_Q14683	Structural maintenance of chromosomes protein 1A	1233	143233	7.51	0	Kinetochore;Nucleoplasm;Nucleus;Chromosome	Cornelia de Lange syndrome 2	Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.	Phosphorylated by ATM upon ionizing radiation in a NBS1-dependent manner. Phosphorylated by ATR upon DNA methylation in a MSH2/MSH6-dependent manner. Phosphorylation of Ser-957 and Ser-966 activates it and is required for S-phase checkpoint activation.	Belongs to the SMC family. SMC1 subfamily.	Cell cycle;Oocyte meiosis;Separation of Sister Chromatids;SUMOylation of DNA damage response and repair proteins;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion;Meiotic synapsis;Estrogen-dependent gene expression	PE1	X
+NX_Q14684	Ribosomal RNA processing protein 1 homolog B	758	84428	9.77	0	Nucleoplasm;Nucleolus;Chromosome	NA	(Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA.;Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015).	Citrullinated by PADI4.	Belongs to the RRP1 family.	NA	PE1	21
+NX_Q14686	Nuclear receptor coactivator 6	2063	219145	9.4	0	Nucleoplasm;Nucleus	NA	Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.	Phosphorylated by PRKDC.;Phosphorylation on Ser-884 leads to a strong decrease in binding to ESR1 and ESR2.	NA	PPARA activates gene expression;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	20
+NX_Q14687	Genetic suppressor element 1	1217	136164	7.36	0	Nucleoplasm;Mitochondrion	NA	NA	NA	NA	NA	PE1	16
+NX_Q14689	Disco-interacting protein 2 homolog A	1571	170369	8.35	0	Nucleoplasm;Nucleus	NA	May provide positional cues for axon pathfinding and patterning in the central nervous system.	NA	Belongs to the DIP2 family.	NA	PE1	21
+NX_Q14690	Protein RRP5 homolog	1871	208701	8.99	0	Cytoplasmic vesicle;Nucleolus	NA	Involved in the biogenesis of rRNA.;Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.	NA	NA	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	10
+NX_Q14691	DNA replication complex GINS protein PSF1	196	22988	6.96	0	Nucleoplasm;Nucleus	Immunodeficiency 55	Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.	NA	Belongs to the GINS1/PSF1 family.	Unwinding of DNA	PE1	20
+NX_Q14692	Ribosome biogenesis protein BMS1 homolog	1282	145807	6.04	0	Nucleoplasm;Nucleolus	Aplasia cutis congenita, non-syndromic	May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	10
+NX_Q14693	Phosphatidate phosphatase LPIN1	890	98664	6.14	0	Cytosol;Endoplasmic reticulum membrane;Nucleus membrane;Cell membrane	Myoglobinuria, acute recurrent, autosomal recessive	Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).	Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway. Phosphorylation is decreased by epinephrine. Phosphorylation may not directly affect the catalytic activity but may regulate the localization. Dephosphorylated by the CTDNEP1-CNEP1R1 complex (By similarity).;Sumoylated.	Belongs to the lipin family.	Synthesis of PC;Synthesis of PE;Triglyceride biosynthesis;Depolymerisation of the Nuclear Lamina	PE1	2
+NX_Q14694	Ubiquitin carboxyl-terminal hydrolase 10	798	87134	5.19	0	Cytoplasm;Early endosome;Nucleoplasm;Cytosol;Nucleus	NA	Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384).	Ubiquitinated. Deubiquitinated by USP13.;Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus.	Belongs to the peptidase C19 family. USP10 subfamily.	Termination of translesion DNA synthesis;Ub-specific processing proteases	PE1	16
+NX_Q14695	Uncharacterized protein KIAA0087	138	14937	9.04	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_Q14696	LRP chaperone MESD	234	26077	7.6	0	Endoplasmic reticulum;Cytosol;Nucleus	NA	Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity).	NA	Belongs to the MESD family.	NA	PE1	15
+NX_Q14697	Neutral alpha-glucosidase AB	944	106874	5.74	0	Golgi apparatus;Endoplasmic reticulum;Melanosome	Polycystic kidney disease 3 with or without polycystic liver disease	Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053).	NA	Belongs to the glycosyl hydrolase 31 family.	Glycan metabolism; N-glycan metabolism.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Calnexin/calreticulin cycle	PE1	11
+NX_Q14699	Raftlin	578	63146	5.46	0	Cytoplasm;Cell membrane;Early endosome;Endosome;Membrane raft	NA	Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216).	NA	Belongs to the raftlin family.	NA	PE1	3
+NX_Q14703	Membrane-bound transcription factor site-1 protease	1052	117749	8.91	1	Endoplasmic reticulum membrane;Golgi apparatus membrane	Spondyloepiphyseal dysplasia, Kondo-Fu type	Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. Involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes (PubMed:30046013). It is required for the activation of CREB3L2/BBF2H7, a transcriptional activator of MIA3/TANGO and other genes controlling mega vesicle formation. Therefore, it plays a key role in the regulation of mega vesicle-mediated collagen trafficking (PubMed:30046013).	The 148 kDa zymogen is processed progressively into two membrane-bound 120 and 106 kDa forms in the endoplasmic reticulum, and late into a secreted 98 kDa form. The propeptide is autocatalytically removed through an intramolecular cleavage after Leu-186. Further cleavage generates 14, 10, and 8 kDa intermediates.	Belongs to the peptidase S8 family.	Protein processing in endoplasmic reticulum;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Regulation of cholesterol biosynthesis by SREBP (SREBF);ATF6 (ATF6-alpha) activates chaperones;CREB3 factors activate genes;Post-translational protein phosphorylation;Assembly of active LPL and LIPC lipase complexes	PE1	16
+NX_Q14714	Sarcospan	243	26618	8.12	4	Postsynaptic cell membrane;Cell membrane;Nucleus membrane;Endoplasmic reticulum;Nucleoplasm;Sarcolemma	NA	Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.	NA	NA	NA	PE1	12
+NX_Q14721	Potassium voltage-gated channel subfamily B member 1	858	95878	8.32	6	Lateral cell membrane;Synaptosome;Postsynaptic cell membrane;Cell membrane;Perikaryon;Membrane;Synapse;Dendrite;Axon;Sarcolemma	Epileptic encephalopathy, early infantile, 26	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:8081723, PubMed:1283219, PubMed:10484328, PubMed:12560340, PubMed:19074135, PubMed:19717558, PubMed:24901643). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity).	Acetylated. Acetylation occurs in pancreatic beta cells in response to stimulation by incretin hormones in a histone acetyltransferase (HAT)/histone deacetylase (HDAC)-dependent signaling pathway, promoting beta cell survival.;Phosphorylated. Differential C-terminal phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating in hippocampal neurons. Ser-607 and Tyr-128 are significant sites of voltage-gated regulation through phosphorylation/dephosphorylation activities. Tyr-128 can be phosphorylated by Src and dephosphorylated by cytoplasmic form of the phosphatase PTPRE. CDK5-induced Ser-607 phosphorylation increases in response to acute blockade of neuronal activity. Phosphorylated on Tyr-128 by Src and on Ser-805 by MAPK14/P38MAPK; phosphorylations are necessary and sufficient for an increase in plasma membrane insertion, apoptotic potassium current surge and completion of the neuronal cell death program. Phosphorylated on Ser-520, Ser-607, Ser-656 and Ser-805 by CDK5; phosphorylation is necessary for KCNB1 channel clustering formation. The Ser-607 phosphorylation state differs between KCNB1-containing clusters on the proximal and distal portions of the axon initial segment (AIS). Highly phosphorylated on serine residues in the C-terminal cytoplasmic tail in resting neurons. Phosphorylated in pancreatic beta cells in response to incretin hormones stimulation in a PKA- and RPS6KA5/MSK1-dependent signaling pathway, promoting beta cell survival. Phosphorylation on Ser-567 is reduced during postnatal development with low levels at P2 and P5; levels then increase to reach adult levels by P14. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are sensitive to calcineurin-mediated dephosphorylation contributing to the modulation of the voltage-dependent gating properties. Dephosphorylation by phosphatase PTPRE confers neuroprotection by its inhibitory influence on the neuronal apoptotic potassium current surge in a Zn(2+)-dependent manner. Dephosphorylated at Ser-607 by protein phosphatase PPP1CA. Hypoxia-, seizure- or glutamate-induced neuronal activity promote calcium/calcineurin-dependent dephosphorylation resulting in a loss of KCNB1-containing clustering and enhanced channel activity. In response to brain ischemia, Ser-567 and Ser-607 are strongly dephosphorylated while Ser-457 and Ser-720 are less dephosphorylated. In response to brain seizures, phosphorylation levels on Ser-567 and Ser-607 are greatly reduced. Phosphorylated/dephosphorylated by Src or FYN tyrosine-protein kinases and tyrosine phosphatase PTPRE in primary Schwann cells and sciatic nerve tissue (By similarity).;Sumoylated on Lys-474, preferentially with SUMO1; sumoylation induces a positive shift in the voltage-dependence of activation and inhibits channel activity (PubMed:19223394). Sumoylation increases the frequency of repetitive action potential firing at the cell surface of hippocampal neurons and decreases its frequency in pancreatic beta cells (PubMed:19223394). Desumoylated by SENP1 (PubMed:19223394).	Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.	Taste transduction;Voltage gated Potassium channels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	PE1	20
+NX_Q14722	Voltage-gated potassium channel subunit beta-1	419	46563	9.1	0	Cytoplasm;Cell membrane;Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).;Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity).	NA	Belongs to the shaker potassium channel beta subunit family.	Voltage gated Potassium channels	PE1	3
+NX_Q14728	Major facilitator superfamily domain-containing protein 10	455	48339	9.68	11	Nucleus inner membrane;Nucleoplasm;Nucleus membrane	NA	Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.	NA	Belongs to the major facilitator superfamily.	NA	PE1	4
+NX_Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	602	69992	8.24	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Mental retardation, autosomal dominant 35	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	NA	Belongs to the phosphatase 2A regulatory subunit B56 family.	mRNA surveillance pathway;Oocyte meiosis;Wnt signaling pathway;Dopaminergic synapse;Degradation of beta-catenin by the destruction complex;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Negative regulation of MAPK pathway;RAF activation;DARPP-32 events;Disassembly of the destruction complex and recruitment of AXIN to the membrane;CTLA4 inhibitory signaling;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Platelet sensitization by LDL;ERK/MAPK targets;Integration of energy metabolism;PP2A-mediated dephosphorylation of key metabolic factors;ERKs are inactivated;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	6
+NX_Q14739	Delta(14)-sterol reductase LBR	615	70703	9.41	8	Cytoplasm;Endoplasmic reticulum membrane;Nucleus membrane;Nucleus inner membrane;Nucleus	Pelger-Huet anomaly;Reynolds syndrome;Pelger-Huet anomaly with mild skeletal anomalies;Greenberg dysplasia	Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:9630650, PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963).	Phosphorylated by CDK1 in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated by SRPK1. In late anaphase LBR is dephosphorylated, probably by PP1 and/or PP2A, allowing reassociation with chromatin.;LBR is phosphorylated by SRPK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);LBR is phosphorylated by SRPK1 (Phosphoserine:PTM-0253)	Belongs to the ERG4/ERG24 family.	Steroid biosynthesis; cholesterol biosynthesis.;Cholesterol biosynthesis;Regulation of MECP2 expression and activity	PE1	1
+NX_Q14746	Conserved oligomeric Golgi complex subunit 2	738	83208	6.2	0	Golgi apparatus;Golgi apparatus membrane	Congenital disorder of glycosylation 2Q	Required for normal Golgi morphology and function.	NA	Belongs to the COG2 family.	Intra-Golgi traffic;COPI-mediated anterograde transport;Retrograde transport at the Trans-Golgi-Network	PE1	1
+NX_Q14749	Glycine N-methyltransferase	295	32742	6.55	0	Cytoplasm;Cytosol	Glycine N-methyltransferase deficiency	Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.	Glycine, serine and threonine metabolism;Glyoxylate metabolism and glycine degradation;Metabolism of ingested SeMet, Sec, MeSec into H2Se	PE1	6
+NX_Q14761	Protein tyrosine phosphatase receptor type C-associated protein	206	21196	4.39	1	Membrane	NA	NA	Phosphorylated on tyrosine residues.	NA	NA	PE1	11
+NX_Q14764	Major vault protein	893	99327	5.34	0	Cytoplasm;Cytosol;Perinuclear region;Nuclear pore complex	NA	Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.	Dephosphorylated by PTPN11.;Phosphorylated on Tyr residues after EGF stimulation.;MVP is phosphorylated by SRC	NA	Neutrophil degranulation	PE1	16
+NX_Q14765	Signal transducer and activator of transcription 4	748	85941	6.2	0	Cytoplasm;Nucleus	Systemic lupus erythematosus 11;Rheumatoid arthritis	Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.	Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).	Belongs to the transcription factor STAT family.	Jak-STAT signaling pathway;Interleukin-20 family signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Interleukin-35 Signalling;Interleukin-12 signaling;Interleukin-23 signaling;Interleukin-21 signaling	PE1	2
+NX_Q14766	Latent-transforming growth factor beta-binding protein 1	1721	186796	5.63	0	Cytosol;Extracellular matrix;Secreted	NA	Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742).	Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix.;N-terminus is blocked.;Contains hydroxylated asparagine residues.	Belongs to the LTBP family.	TGF-beta signaling pathway;Molecules associated with elastic fibres;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	2
+NX_Q14767	Latent-transforming growth factor beta-binding protein 2	1821	195052	5.06	0	Nucleoplasm;Extracellular matrix	Glaucoma 3, primary congenital, D;Weill-Marchesani syndrome 3;Microspherophakia and/or megalocornea, with ectopia lentis and with or without secondary glaucoma	May play an integral structural role in elastic-fiber architectural organization and/or assembly.	Contains hydroxylated asparagine residues.;N-Glycosylated.	Belongs to the LTBP family.	Molecules associated with elastic fibres	PE1	14
+NX_Q14773	Intercellular adhesion molecule 4	271	29265	10.13	1	Secreted;Cell membrane	NA	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.	N- and O-glycosylated.	Belongs to the immunoglobulin superfamily. ICAM family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions	PE1	19
+NX_Q14774	H2.0-like homeobox protein	488	50789	8.7	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).	NA	Belongs to the H2.0 homeobox family.	NA	PE1	1
+NX_Q14781	Chromobox protein homolog 2	532	56081	10.02	0	Nucleoplasm;Nucleus;Chromosome	46,XY sex reversal 5	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).	NA	NA	SUMOylation of DNA damage response and repair proteins;Oxidative Stress Induced Senescence;SUMOylation of RNA binding proteins;SUMOylation of chromatin organization proteins;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins	PE1	17
+NX_Q14789	Golgin subfamily B member 1	3259	376019	4.96	1	Golgi apparatus;Golgi apparatus membrane	NA	May participate in forming intercisternal cross-bridges of the Golgi complex.	NA	NA	Golgi Associated Vesicle Biogenesis;COPI-mediated anterograde transport	PE1	3
+NX_Q14790	Caspase-8	479	55391	5	0	Cytoplasm;Nucleoplasm;Cytosol	Caspase-8 deficiency	Lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.;Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.	Phosphorylation on Ser-387 during mitosis by CDK1 inhibits activation by proteolysis and prevents apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes.;Generation of the subunits requires association with the death-inducing signaling complex (DISC), whereas additional processing is likely due to the autocatalytic activity of the activated protease. GZMB and CASP10 can be involved in these processing events.	Belongs to the peptidase C14A family.	p53 signaling pathway;Apoptosis;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Alzheimer's disease;Huntington's disease;Legionellosis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Herpes simplex infection;Pathways in cancer;Viral myocarditis;NOD1/2 Signaling Pathway;Caspase-mediated cleavage of cytoskeletal proteins;Activation, myristolyation of BID and translocation to mitochondria;Apoptotic cleavage of cellular proteins;CLEC7A/inflammasome pathway;TNFR1-induced proapoptotic signaling;Caspase activation via Death Receptors in the presence of ligand;TRIF-mediated programmed cell death;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TRAIL signaling;Regulation of necroptotic cell death;FasL/ CD95L signaling;Apoptotic execution phase;Regulation of TNFR1 signaling;TLR3-mediated TICAM1-dependent programmed cell death	PE1	2
+NX_Q147U1	Zinc finger protein 846	533	60552	9.21	0	Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q147U7	Single-pass membrane and coiled-coil domain-containing protein 1	214	24598	9.2	1	Membrane	NA	NA	NA	NA	NA	PE2	3
+NX_Q147X3	N-alpha-acetyltransferase 30	362	39320	5.38	0	Cytoplasm;Cytosol;Nucleus	NA	Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate.	NA	Belongs to the acetyltransferase family. MAK3 subfamily.	Retrograde transport at the Trans-Golgi-Network	PE1	14
+NX_Q14802	FXYD domain-containing ion transport regulator 3	87	9263	6.8	1	Nucleoplasm;Cell membrane	NA	Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447).;Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials.;Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials.	Glutathionylated.	Belongs to the FXYD family.	Ion transport by P-type ATPases;Ion homeostasis	PE1	19
+NX_Q14807	Kinesin-like protein KIF22	665	73262	9.5	0	Nucleus speckle;Nucleus;Cytoskeleton	Spondyloepimetaphyseal dysplasia with joint laxity, 2	Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205).	Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	MHC class II antigen presentation;Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	16
+NX_Q14814	Myocyte-specific enhancer factor 2D	521	55938	7.73	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity).	Acetylated on Lys-439 by CREBBP. Acetylated by EP300. Deacetylated by SIRT1 and HDAC3.;Sumoylated on Lys-439 with SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity. Desumoylated by SENP3.;Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity).;Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phosphorylation on Ser-180 can be enhanced by EGF. Phosphorylated and activated by CaMK4.;MEF2D is phosphorylated by CAMK4	Belongs to the MEF2 family.	Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Myogenesis	PE1	1
+NX_Q14831	Metabotropic glutamate receptor 7	915	102251	8.2	7	Cytosol;Cell membrane	NA	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.	NA	Belongs to the G-protein coupled receptor 3 family.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	3
+NX_Q14832	Metabotropic glutamate receptor 3	879	98879	7.93	7	Cell membrane	NA	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.	NA	Belongs to the G-protein coupled receptor 3 family.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	7
+NX_Q14833	Metabotropic glutamate receptor 4	912	101868	9.07	7	Cell membrane	NA	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.	NA	Belongs to the G-protein coupled receptor 3 family.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	6
+NX_Q14839	Chromodomain-helicase-DNA-binding protein 4	1912	218005	5.62	0	Centrosome;Nucleus	Sifrim-Hitz-Weiss syndrome	Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.	NA	Belongs to the SNF2/RAD54 helicase family.	RNA Polymerase I Transcription Initiation;HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;Regulation of PTEN gene transcription	PE1	12
+NX_Q14847	LIM and SH3 domain protein 1	261	29717	6.61	0	Cytoplasm;Cell cortex;Cell membrane;Focal adhesion;Cytosol;Cytoskeleton	NA	Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).	NA	NA	NA	PE1	17
+NX_Q14849	StAR-related lipid transfer protein 3	445	50502	8.53	4	Endoplasmic reticulum;Nucleoplasm;Late endosome membrane;Cytoplasmic vesicle	NA	Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).	NA	Belongs to the STARD3 family.	Pregnenolone biosynthesis	PE1	17
+NX_Q14863	POU domain, class 6, transcription factor 1	301	32645	9.24	0	Nucleus;Cytoskeleton	NA	Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').	NA	Belongs to the POU transcription factor family. Class-6 subfamily.	NA	PE1	12
+NX_Q14865	AT-rich interactive domain-containing protein 5B	1188	132375	8.89	0	Cell membrane;Nucleoplasm;Endoplasmic reticulum;Cytosol;Nucleus	Leukemia, acute lymphoblastic	Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.	Methylation at Lys-336 prevents DNA-binding. Demethylation by PHF2 promotes recruitment of the PHF2-ARID5B complex to promoters.	Belongs to the ARID5B family.	HDMs demethylate histones	PE1	10
+NX_Q14872	Metal regulatory transcription factor 1	753	80957	5.14	0	Nucleoplasm;Nucleus	NA	Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).	NA	NA	PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);MTF1 activates gene expression	PE1	1
+NX_Q14894	Ketimine reductase mu-crystallin	314	33776	5.06	0	Cytoplasm;Cytosol	Deafness, autosomal dominant, 40	Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.	NA	Belongs to the ornithine cyclodeaminase/mu-crystallin family.	Lysine catabolism	PE1	16
+NX_Q14896	Myosin-binding protein C, cardiac-type	1274	140762	6.24	0	NA	Left ventricular non-compaction 10;Cardiomyopathy, dilated 1MM;Cardiomyopathy, familial hypertrophic 4	Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.	Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction (By similarity).;Polyubiquitinated.;MYBPC3 is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254);MYBPC3 is phosphorylated by PRKCE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the immunoglobulin superfamily. MyBP family.	Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;Striated Muscle Contraction	PE1	11
+NX_Q14914	Prostaglandin reductase 1	329	35870	8.45	0	Cytoplasm	NA	Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.	NA	Belongs to the NADP-dependent oxidoreductase L4BD family.	Synthesis of Leukotrienes (LT) and Eoxins (EX);Synthesis of Lipoxins (LX)	PE1	9
+NX_Q14916	Sodium-dependent phosphate transport protein 1	467	51132	8.89	10	Golgi apparatus;Apical cell membrane	NA	Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney (PubMed:27906618).	NA	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.	Organic anion transporters	PE1	6
+NX_Q14919	Dr1-associated corepressor	205	22350	5.04	0	Cytosol;Nucleus	NA	The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.	Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.	Belongs to the NC2 alpha/DRAP1 family.	Signaling by NODAL;Signaling by Activin	PE1	11
+NX_Q14929	Zinc finger protein 169	603	68488	9.36	0	Cytosol;Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	9
+NX_Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	902	95449	5.29	0	Cytosol;Nucleus speckle;Nucleus	NA	Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:7749981, PubMed:11514544, PubMed:11997522, PubMed:17875713, PubMed:17213202, PubMed:18668201, PubMed:25663301). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:7749981, PubMed:18668201, PubMed:18347059). Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity).	Ubiquitinated, leading to degradation by the proteasome. Ubiquitination may be stimulated by GSK3B-dependent phosphorylation. Polyubiquitin linkage mainly occurs through 'Lys-48'.;Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin/PPP3CA. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7/ERK5 and MAPK14/p38, on Ser-213 and Ser-217 by MAPK8/JNK1 and MAPK9/JNK2, and on Ser-289 and Ser-344 by RPS6KA3 (PubMed:11997522, PubMed:17875713, PubMed:17213202, PubMed:18347059). Phosphorylated by GSK3B (PubMed:18347059). Phosphorylation by GSK3B markedly increases NFATC4 ubiquitination (By similarity). Phosphorylation at Ser-168 and Ser-170 is stimulated by UV irradiation (PubMed:18347059). Phosphorylation determines subcellular location: the hyperphosphorylated protein is cytosolic, while the dephosphorylated form is targeted to the nucleus.;NFATC4 is phosphorylated by RPS6KA3 (Phosphoserine:PTM-0253);NFATC4 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	MAPK signaling pathway;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;HTLV-I infection	PE1	14
+NX_Q14938	Nuclear factor 1 X-type	502	55098	8.9	0	Nucleus	Marshall-Smith syndrome;Sotos syndrome 2	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.	NA	Belongs to the CTF/NF-I family.	RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation	PE1	19
+NX_Q14940	Sodium/hydrogen exchanger 5	896	99011	7.33	12	Membrane;Nucleoplasm;Cytosol	NA	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).	Phosphorylated (Possible).	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Sodium/Proton exchangers	PE1	16
+NX_Q14943	Killer cell immunoglobulin-like receptor 3DS1	382	42475	9.59	1	Cell membrane	NA	Receptor on natural killer (NK) cells for MHC class I molecules. Upon interaction with peptide-free HLA-F open conformer, triggers NK cell degranulation and anti-viral cytokine production.	NA	Belongs to the immunoglobulin superfamily.	DAP12 interactions	PE1	19
+NX_Q14952	Killer cell immunoglobulin-like receptor 2DS3	304	33717	6.1	1	Cell membrane	NA	Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.	NA	Belongs to the immunoglobulin superfamily.	Antigen processing and presentation;Natural killer cell mediated cytotoxicity	PE2	19
+NX_Q14953	Killer cell immunoglobulin-like receptor 2DS5	304	33698	6.26	1	Cell membrane	NA	Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:28685972, PubMed:18624290, PubMed:18682925). Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry (PubMed:28685972).	N-glycosylated, glycosylation varies depending on the allele which alters cell surface expression levels.	Belongs to the immunoglobulin superfamily.	DAP12 interactions	PE1	19
+NX_Q14954	Killer cell immunoglobulin-like receptor 2DS1	304	33618	6.09	1	Cell membrane	NA	Receptor on natural killer (NK) cells for some HLA-C alleles such as w6. Does not inhibit the activity of NK cells.	NA	Belongs to the immunoglobulin superfamily.	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 interactions	PE1	19
+NX_Q14956	Transmembrane glycoprotein NMB	572	63923	6.17	1	Early endosome membrane;Melanosome membrane;Cell membrane	Amyloidosis, primary localized cutaneous, 3	Could be a melanogenic enzyme.	NA	Belongs to the PMEL/NMB family.	PTK6 promotes HIF1A stabilization	PE1	7
+NX_Q14957	Glutamate receptor ionotropic, NMDA 2C	1233	134209	8.82	3	Postsynaptic cell membrane;Cell membrane	NA	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).	NA	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Long-term potentiation;Glutamatergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Unblocking of NMDA receptors, glutamate binding and activation;Synaptic adhesion-like molecules;Neurexins and neuroligins;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	17
+NX_Q14964	Ras-related protein Rab-39A	217	25007	7.57	0	Phagosome membrane;Lysosome;Phagosome;Cell membrane	NA	Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (PubMed:24349490). May be involved in multiple neurite formation (By similarity).	NA	Belongs to the small GTPase superfamily. Rab family.	Intra-Golgi traffic;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	11
+NX_Q14966	Zinc finger protein 638	1978	220625	6.02	0	Nucleoplasm;Nucleus speckle;Cytoplasmic vesicle	NA	Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity).	NA	NA	Transcriptional regulation of white adipocyte differentiation	PE1	2
+NX_Q14973	Sodium/bile acid cotransporter	349	38119	9.07	8	Membrane	NA	(Microbial infection) Acts as a receptor for hepatitis B virus.;The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.	NA	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.	Bile secretion;Recycling of bile acids and salts	PE1	14
+NX_Q14974	Importin subunit beta-1	876	97170	4.68	0	Cytoplasm;Nucleus membrane;Nucleoplasm;Nucleus envelope;Cytosol	NA	Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.	Mono-ADP-ribosylated by PARP16.	Belongs to the importin beta family. Importin beta-1 subfamily.	RNA transport;ISG15 antiviral mechanism;Nuclear import of Rev protein;Transport of Ribonucleoproteins into the Host Nucleus;Regulation of cholesterol biosynthesis by SREBP (SREBF);NS1 Mediated Effects on Host Pathways;Neutrophil degranulation;Apoptosis induced DNA fragmentation	PE1	17
+NX_Q14978	Nucleolar and coiled-body phosphoprotein 1	699	73603	9.46	0	Cytoplasm;Nucleolus	NA	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).	Ubiquitinated. Monoubiquitination by the BCR(KBTBD8) complex promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).;Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. NOLC1 is one of the mostly phosphorylated proteins in the cell.	Belongs to the NOLC1 family.	NA	PE1	10
+NX_Q14980	Nuclear mitotic apparatus protein 1	2115	238260	5.63	0	Cell cortex;Lateral cell membrane;Cell membrane;Nucleus matrix;Chromosome;Nucleoplasm;Spindle pole;Centrosome;Cytosol;Nucleus;Cytoskeleton	NA	Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity).	O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status (PubMed:20068230).;Phosphorylation and dephosphorylation on Thr-2055 regulates the extent of cortical NUMA1 and the dynein-dynactin complex localization during mitotic metaphase and anaphase (PubMed:23921553). In metaphase, phosphorylation on Thr-2055 occurs in a kinase CDK1-dependent manner; this phosphorylation maintains low levels of cortical dynein-dynactin complex at metaphase, and hence proper spindle positioning (PubMed:7769006, PubMed:23921553, PubMed:24371089). In anaphase, dephosphorylated on Thr-2055 by phosphatase PPP2CA; this dephosphorylation stimulates its membrane association and with the dynein-dynactin complex its enrichment at the cell cortex, and hence robust spindle elongation (PubMed:23921553, PubMed:24371089). Probably also phosphorylated on Thr-2015 and Ser-2087 by CDK1; these phosphorylations may regulate its cell cortex recruitment during metaphase and anaphase (PubMed:23870127). Phosphorylated on Thr-1047, Ser-1769, Ser-1772, Ser-1789 and Ser-1834 by PLK1; these phosphorylations induce cortical dynein-dynactin complex dissociation from the NUMA1-GPSM2 complex and negatively regulates cortical dynein-dynactin complex localization (PubMed:22327364).;ADP-ribosylated by TNKS at the onset of mitosis; ADP-ribosylation is not required for its localization to spindle poles (PubMed:16076287).;Ubiquitinated with 'Lys-63'-linked polyubiquitin chains. Deubiquitination by the BRISC complex is important for the incorporation of NUMA1 into mitotic spindle poles and normal spindle pole function, probably by modulating interactions between NUMA1, dynein-dynactin complex and importin-beta.;NUMA1 is phosphorylated by MAPK3	NA	Recruitment of NuMA to mitotic centrosomes;Mitotic Prophase	PE1	11
+NX_Q14982	Opioid-binding protein/cell adhesion molecule	345	38008	6.45	0	Cell membrane	Ovarian cancer	Binds opioids in the presence of acidic lipids; probably involved in cell contact.	NA	Belongs to the immunoglobulin superfamily. IgLON family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	11
+NX_Q14990	Outer dense fiber protein 1	250	28366	8.46	0	NA	NA	Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.	NA	NA	NA	PE1	8
+NX_Q14993	Collagen alpha-1(XIX) chain	1142	115221	8.57	0	Extracellular matrix	NA	May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.	Collagen degradation;Collagen biosynthesis and modifying enzymes;Collagen chain trimerization	PE1	6
+NX_Q14994	Nuclear receptor subfamily 1 group I member 3	352	39942	8.55	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoskeleton	NA	Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.	Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Nuclear Receptor transcription pathway	PE1	1
+NX_Q14995	Nuclear receptor subfamily 1 group D member 2	579	64625	8.04	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle (By similarity). Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (By similarity). Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (By similarity). May play a role in the circadian control of neutrophilic inflammation in the lung (By similarity).	Ubiquitinated by SIAH2; leading to proteasomal degradation.;Deacetylated by HDAC1. Acetylation and deacetylation regulate its transcriptional regulatory activity.;Phosphorylated by CSNK1E; phosphorylation enhances its cytoplasmic localization.;Under more reducing intracellular redox conditions, Cys-384 is in its heme-bound state, which is optimal for recruitment of the NCOR1/HDAC3 corepressor complex and repression of target genes. When subjected to oxidative stress conditions, Cys-384 undergoes oxidation to form a disulfide bridge with Cys-374, also triggering a ligand switch that results in release of bound heme and derepression of target genes.	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Nuclear Receptor transcription pathway	PE1	3
+NX_Q14997	Proteasome activator complex subunit 4	1843	211334	6.45	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.	NA	Belongs to the BLM10 family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	2
+NX_Q14999	Cullin-7	1698	191161	5.57	0	Golgi apparatus;Cytoplasm;Perinuclear region;Centrosome	3M syndrome 1	Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions.	According to a report, may not be neddylated despite the conserved consensus site for neddylation at Lys-1576.	Belongs to the cullin family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;XBP1(S) activates chaperone genes;Neddylation	PE1	6
+NX_Q149M9	NACHT domain- and WD repeat-containing protein 1	1564	174552	6.28	0	Cytosol	NA	May play a role in the control of androgen receptor (AR) protein steady-state levels.	NA	NA	NA	PE1	19
+NX_Q149N8	E3 ubiquitin-protein ligase SHPRH	1683	193079	7.3	0	Mitochondrion	NA	E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.	NA	Belongs to the SNF2/RAD54 helicase family.	Protein modification; protein ubiquitination.;E3 ubiquitin ligases ubiquitinate target proteins	PE1	6
+NX_Q14BN4	Sarcolemmal membrane-associated protein	828	95198	5.35	1	Endoplasmic reticulum;Sarcolemma;Centrosome	NA	May play a role during myoblast fusion.	NA	Belongs to the SLMAP family.	NA	PE1	3
+NX_Q14C86	GTPase-activating protein and VPS9 domain-containing protein 1	1478	164980	5.09	0	Membrane;Cytosol;Endosome;Cell membrane	NA	Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.	NA	Belongs to the GAPVD1 family.	Clathrin-mediated endocytosis;RAB GEFs exchange GTP for GDP on RABs	PE1	9
+NX_Q14C87	Transmembrane protein 132D	1099	122309	5.5	1	Membrane	NA	May serve as a cell-surface marker for oligodendrocyte differentiation.	NA	Belongs to the TMEM132 family.	NA	PE1	12
+NX_Q14CB8	Rho GTPase-activating protein 19	494	55756	9.41	0	Nucleus;Cell membrane	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	NA	NA	Rho GTPase cycle	PE1	10
+NX_Q14CM0	FERM and PDZ domain-containing protein 4	1322	144379	5.12	0	Dendritic spine	Mental retardation, X-linked 104	Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.	NA	NA	NA	PE1	X
+NX_Q14CN2	Calcium-activated chloride channel regulator 4	919	101283	5.27	1	Cell membrane;Apical cell membrane;Secreted;Nucleoplasm;Cytosol	NA	May be involved in mediating calcium-activated chloride conductance.	The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.	Belongs to the CLCR family.	Olfactory transduction;Pancreatic secretion;Stimuli-sensing channels	PE1	1
+NX_Q14CN4	Keratin, type II cytoskeletal 72	511	55877	6.53	0	NA	NA	Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q14CS0	UBX domain-containing protein 2B	331	37077	5.49	0	Golgi apparatus;Endoplasmic reticulum;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807).	NA	Belongs to the NSFL1C family.	NA	PE1	8
+NX_Q14CW9	Ataxin-7-like protein 3	347	38651	6.62	0	Nucleus speckle;Nucleus;Cell membrane	NA	Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583).	NA	Belongs to the SGF11 family.	HATs acetylate histones	PE1	17
+NX_Q14CX5	Transmembrane protein 180	517	57381	8.21	11	Membrane;Golgi apparatus;Cytosol	NA	NA	NA	NA	NA	PE2	10
+NX_Q14CX7	N-alpha-acetyltransferase 25, NatB auxiliary subunit	972	112292	6.21	0	Golgi apparatus;Cytoplasm;Cytosol	NA	Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.	NA	Belongs to the MDM20/NAA25 family.	NA	PE1	12
+NX_Q14CZ0	UPF0472 protein C16orf72	275	30926	7.77	0	Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	Belongs to the UPF0472 family.	NA	PE1	16
+NX_Q14CZ7	FAST kinase domain-containing protein 3, mitochondrial	662	75689	8.62	0	Nucleoplasm;Mitochondrion	NA	Required for normal mitochondrial respiration (PubMed:20869947). Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity (PubMed:27789713).	NA	Belongs to the FAST kinase family.	NA	PE1	5
+NX_Q14CZ8	Hepatocyte cell adhesion molecule	416	46026	9.2	1	Membrane;Cytoplasmic vesicle;Cytoplasm	Leukoencephalopathy, megalencephalic, with subcortical cysts, 2B;Leukoencephalopathy, megalencephalic, with subcortical cysts, 2A	Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation.	N-glycosylated.	NA	NA	PE1	11
+NX_Q14D04	Ventricular zone-expressed PH domain-containing protein homolog 1	833	94745	6.26	0	Nucleoplasm;Cytosol;Nucleolus;Cell membrane	NA	Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.	NA	Belongs to the MELT/VEPH family.	NA	PE1	3
+NX_Q14D33	Receptor-transporting protein 5	572	60488	6.12	1	Membrane	NA	NA	NA	NA	Olfactory Signaling Pathway	PE1	2
+NX_Q14DG7	Transmembrane protein 132B	1078	119477	4.63	1	Membrane	NA	NA	NA	Belongs to the TMEM132 family.	NA	PE1	12
+NX_Q15003	Condensin complex subunit 2	741	82563	4.92	0	Cytoplasm;Chromosome;Nucleoplasm;Cytosol;Nucleus	Microcephaly 23, primary, autosomal recessive	Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).	Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).	Belongs to the CND2 (condensin subunit 2) family.	Condensation of Prometaphase Chromosomes	PE1	2
+NX_Q15004	PCNA-associated factor	111	11986	9.85	0	Perinuclear region;Centrosome;Nucleus	NA	PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.	Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome.	NA	Termination of translesion DNA synthesis	PE1	15
+NX_Q15005	Signal peptidase complex subunit 2	226	25003	8.69	2	Microsome membrane;Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Nucleoplasm	NA	Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.	NA	Belongs to the SPCS2 family.	Protein export;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);SRP-dependent cotranslational protein targeting to membrane;Synthesis, secretion, and deacylation of Ghrelin	PE1	11
+NX_Q15006	ER membrane protein complex subunit 2	297	34834	6.15	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the EMC2 family.	NA	PE1	8
+NX_Q15007	Pre-mRNA-splicing regulator WTAP	396	44244	5.12	0	Nucleoplasm;Cytoplasm;Nucleus speckle	NA	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).	NA	Belongs to the fl(2)d family.	Processing of Capped Intron-Containing Pre-mRNA	PE1	6
+NX_Q15008	26S proteasome non-ATPase regulatory subunit 6	389	45531	5.45	0	Golgi apparatus;Cytoplasmic vesicle;Cytoplasm;Nucleus	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.	NA	Belongs to the proteasome subunit S10 family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	3
+NX_Q15011	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein	391	43720	5.11	2	Cytosol;Endoplasmic reticulum membrane;Cell membrane	NA	Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982).	NA	NA	Protein processing in endoplasmic reticulum;ATF4 activates genes in response to endoplasmic reticulum stress	PE1	16
+NX_Q15012	Lysosomal-associated transmembrane protein 4A	233	26801	6.1	4	Golgi apparatus;Endomembrane system;Cell membrane;Cytoplasmic vesicle	NA	May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.	NA	Belongs to the LAPTM4/LAPTM5 transporter family.	Lysosome	PE1	2
+NX_Q15013	MAD2L1-binding protein	274	31052	5.94	0	Nucleus membrane;Nucleolus;Nucleoplasm;Spindle;Nucleus	NA	May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.	NA	Belongs to the MAD2L1BP family.	NA	PE1	6
+NX_Q15014	Mortality factor 4-like protein 2	288	32308	9.72	0	Nucleoplasm;Nucleus	NA	Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.	NA	NA	HATs acetylate histones	PE1	X
+NX_Q15018	BRISC complex subunit Abraxas 2	415	46901	5.83	0	Cytoplasm;Spindle pole;Cytosol;Nucleus;Cytoskeleton	NA	Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148).	NA	Belongs to the FAM175 family. Abro1 subfamily.	Metalloprotease DUBs	PE1	10
+NX_Q15019	Septin-2	361	41487	6.15	0	Kinetochore;Cytoplasm;Cell cortex;Cleavage furrow;Cell membrane;Nucleoplasm;Flagellum;Cilium membrane;Spindle;Midbody;Cytoskeleton	NA	Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	Anchoring of the basal body to the plasma membrane	PE1	2
+NX_Q15020	Squamous cell carcinoma antigen recognized by T-cells 3	963	109935	5.45	0	Cajal body;Nucleoplasm;Cytoplasm;Nucleus speckle	NA	Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.;U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity).	NA	NA	NA	PE1	12
+NX_Q15021	Condensin complex subunit 1	1401	157182	6.19	0	Cytoplasm;Nucleolus;Chromosome;Nucleoplasm;Cytosol;Nucleus	Microcephaly 21, primary, autosomal recessive	Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).	Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).	Belongs to the CND1 (condensin subunit 1) family.	Condensation of Prometaphase Chromosomes	PE1	12
+NX_Q15022	Polycomb protein SUZ12	739	83055	8.98	0	Nucleoplasm;Nucleolus;Nucleus	NA	Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.	Sumoylated, probably by PIAS2.	Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.	PKMTs methylate histone lysines;Oxidative Stress Induced Senescence;PRC2 methylates histones and DNA;Activation of anterior HOX genes in hindbrain development during early embryogenesis;SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6;Regulation of PTEN gene transcription	PE1	17
+NX_Q15024	Exosome complex component RRP42	291	31821	5.08	0	Cytoplasm;Nucleus;Nucleus speckle;Nucleolus	NA	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.	NA	Belongs to the RNase PH family.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;mRNA decay by 3' to 5' exoribonuclease;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	3
+NX_Q15025	TNFAIP3-interacting protein 1	636	71864	6.23	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.	Phosphorylation at Tyr-552 by SRC-family kinases recruits phosphoinositide-3-kinase (PI3K) PIK3CD:p85 heterodimer which results in integrin activation and leukocyte adhesion to activated endothelium during inflammation.	NA	Ovarian tumor domain proteases	PE1	5
+NX_Q15027	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1	740	81536	7.6	0	Golgi apparatus;Cytoplasm;Recycling endosome membrane	NA	GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.	Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.	NA	Endocytosis	PE1	17
+NX_Q15029	116 kDa U5 small nuclear ribonucleoprotein component	972	109436	4.84	0	Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	Mandibulofacial dysostosis with microcephaly	Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30705154). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661).	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	17
+NX_Q15031	Probable leucine--tRNA ligase, mitochondrial	903	101976	8.46	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	Hydrops, lactic acidosis, and sideroblastic anemia;Perrault syndrome 4	NA	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	3
+NX_Q15032	R3H domain-containing protein 1	1099	120696	8.91	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	2
+NX_Q15034	Probable E3 ubiquitin-protein ligase HERC3	1050	117188	5.86	0	Cytoplasmic vesicle;Cytosol;Cytoplasm	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	Ubiquitinated; which promotes degradation by the proteasome.	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	4
+NX_Q15035	Translocating chain-associated membrane protein 2	370	43328	9.32	8	Membrane;Cytosol	NA	Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293).	NA	Belongs to the TRAM family.	NA	PE1	6
+NX_Q15036	Sorting nexin-17	470	52901	7.07	0	Cytoplasmic vesicle membrane;Early endosome;Cytoplasm;Cytoplasmic vesicle	NA	Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:28892079, PubMed:22492727). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798).	NA	Belongs to the sorting nexin family.	NA	PE1	2
+NX_Q15038	DAZ-associated protein 2	168	17319	6.69	0	Cytoplasm;Nucleus speckle;Nucleus	NA	NA	Ubiquitinated by SMURF2, leading to proteasomal degradation.	NA	NA	PE1	12
+NX_Q15040	Josephin-1	202	23198	8.78	0	Cytoplasm;Cell membrane	NA	Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.	Monoubiquitinated (By similarity). Ubiquitination activates deubiquitination activity in vitro.	NA	Josephin domain DUBs	PE1	22
+NX_Q15041	ADP-ribosylation factor-like protein 6-interacting protein 1	203	23363	9.38	3	Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Endomembrane system;Endoplasmic reticulum	Spastic paraplegia 61, autosomal recessive	Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579).	NA	Belongs to the ARL6ip family.	NA	PE1	16
+NX_Q15042	Rab3 GTPase-activating protein catalytic subunit	981	110524	5.38	0	Nucleoplasm;Cytosol;Cytoplasm	Warburg micro syndrome 1	Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.	NA	Belongs to the Rab3-GAP catalytic subunit family.	COPI-independent Golgi-to-ER retrograde traffic;RAB GEFs exchange GTP for GDP on RABs	PE1	2
+NX_Q15043	Zinc transporter ZIP14	492	54212	5.16	6	Cytoplasm;Golgi apparatus;Cell membrane;Endoplasmic reticulum;Lamellipodium	Hyperostosis cranialis interna;Hypermanganesemia with dystonia 2	Broad-scope metal ion transporter with a preference for zinc uptake (PubMed:29621230). Also mediates cellular uptake of nontransferrin-bound iron.	NA	Belongs to the ZIP transporter (TC 2.A.5) family.	Zinc influx into cells by the SLC39 gene family	PE1	8
+NX_Q15046	Lysine--tRNA ligase	597	68048	5.94	0	Cytoplasm;Mitochondrion;Cell membrane;Secreted;Cytosol;Nucleus	Deafness, autosomal recessive, 89;Charcot-Marie-Tooth disease, recessive, intermediate type, B	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739).;(Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.	Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE).	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation;Cytosolic tRNA aminoacylation;Selenoamino acid metabolism	PE1	16
+NX_Q15047	Histone-lysine N-methyltransferase SETDB1	1291	143157	5.74	0	Cytoplasm;Chromosome;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:17952062). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:27732843, PubMed:14536086). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086, PubMed:15327775). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).	Degraded by the proteasome, shielded by interaction with ATF7IP.	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	Lysine degradation;PKMTs methylate histone lysines	PE1	1
+NX_Q15048	Leucine-rich repeat-containing protein 14	493	54513	6.43	0	Nucleoplasm;Cytoplasm;Cytosol	NA	Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.	NA	Belongs to the PRAME family. LRRC14 subfamily.	NA	PE1	8
+NX_Q15049	Membrane protein MLC1	377	41141	7.46	8	Membrane;Endoplasmic reticulum;Perinuclear region;Cell membrane	Leukoencephalopathy, megalencephalic, with subcortical cysts, 1	Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.	NA	NA	NA	PE1	22
+NX_Q15050	Ribosome biogenesis regulatory protein homolog	365	41193	10.69	0	Nucleolus	NA	Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.	Citrullinated by PADI4.	Belongs to the RRS1 family.	NA	PE1	8
+NX_Q15051	IQ calmodulin-binding motif-containing protein 1	598	68929	9.19	0	Spindle;Centrosome;Centriole;Cytoskeleton	Senior-Loken syndrome 5;Leber congenital amaurosis 10	Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655).	NA	NA	Anchoring of the basal body to the plasma membrane	PE1	3
+NX_Q15052	Rho guanine nucleotide exchange factor 6	776	87499	5.79	0	Lamellipodium;Cytosol	NA	Acts as a RAC1 guanine nucleotide exchange factor (GEF).	NA	NA	Regulation of actin cytoskeleton;Pancreatic cancer;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components;G beta:gamma signalling through CDC42	PE1	X
+NX_Q15053	Uncharacterized protein KIAA0040	99	11435	9.54	1	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_Q15054	DNA polymerase delta subunit 3	466	51400	9.38	0	Nucleoplasm;Cytoplasm;Nucleus	NA	As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the POLZ complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).	Ubiquitinated, but not targeted to the proteasome (PubMed:16934752). Sumoylated (PubMed:16934752, PubMed:25218447). Sumoylation with SUMO3 may be predominant (PubMed:16934752).;Phosphorylation at Ser-458 is catalyzed in vitro by PKA. It is thought to decrease the affinity for PCNA and Pol-delta4 processivity (PubMed:22148433). Can also be phosphorylated in vitro by CDK1-cyclin-A complex, as well as CDK2-cyclin-A and CDK2-cyclin-E complexes. PCNA interferes with CDK-cyclin phosphorylation (PubMed:11595739).	NA	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination;HTLV-I infection;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Termination of translesion DNA synthesis;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Polymerase switching on the C-strand of the telomere;Processive synthesis on the C-strand of the telomere;Telomere C-strand (Lagging Strand) Synthesis;Removal of the Flap Intermediate from the C-strand;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER	PE1	11
+NX_Q15056	Eukaryotic translation initiation factor 4H	248	27385	6.67	0	Cytoplasm;Nucleoplasm;Cytosol;Perinuclear region;Nucleus	NA	Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.	NA	NA	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	PE1	7
+NX_Q15057	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2	778	88029	6.38	0	Endosome;Endosome membrane	NA	GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).	NA	NA	Endocytosis	PE1	3
+NX_Q15058	Kinesin-like protein KIF14	1648	186492	8.06	0	Cytoplasm;Nucleus;Cytosol;Spindle;Midbody;Midbody ring	Microcephaly 20, primary, autosomal recessive;Meckel syndrome 12	Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	RHO GTPases activate CIT	PE1	1
+NX_Q15059	Bromodomain-containing protein 3	726	79542	9.39	0	Nucleus	NA	Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).	NA	NA	NA	PE1	9
+NX_Q15061	WD repeat-containing protein 43	677	74891	5.37	0	Nucleoplasm;Nucleus;Nucleolus fibrillar center;Nucleolus	NA	Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity).	NA	Belongs to the UTP5 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	2
+NX_Q15063	Periostin	836	93314	7.27	0	Golgi apparatus;Nucleoplasm;Extracellular matrix;Secreted	NA	Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).	Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding (PubMed:18450759). According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833).	NA	NA	PE1	13
+NX_Q15067	Peroxisomal acyl-coenzyme A oxidase 1	660	74424	8.35	0	Peroxisome;Nucleolus	Adrenoleukodystrophy, pseudoneonatal	Is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA (PubMed:17603022).;Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (PubMed:17458872, PubMed:17603022).;Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (PubMed:17603022).;Is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (PubMed:17603022).	NA	Belongs to the acyl-CoA oxidase family.	Lipid metabolism; peroxisomal fatty acid beta-oxidation.;Fatty acid metabolism;alpha-Linolenic acid metabolism;Biosynthesis of unsaturated fatty acids;Metabolic pathways;PPAR signaling pathway;Peroxisome;PPARA activates gene expression;alpha-linolenic acid (ALA) metabolism;Beta-oxidation of very long chain fatty acids;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins	PE1	17
+NX_Q15070	Mitochondrial inner membrane protein OXA1L	435	48548	9.53	5	Mitochondrion inner membrane;Mitochondrion	NA	Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria.	NA	Belongs to the OXA1/ALB3/YidC family.	Protein export;Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	14
+NX_Q15072	Zinc finger protein OZF	292	33308	9.15	0	Nucleolus;Nucleus	NA	NA	Sumoylated.	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q15075	Early endosome antigen 1	1411	162466	5.55	0	Endoplasmic reticulum;Cytoplasm;Early endosome membrane;Cytoplasmic vesicle	NA	Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.	NA	NA	Toll Like Receptor 9 (TLR9) Cascade	PE1	12
+NX_Q15077	P2Y purinoceptor 6	328	36429	9.61	7	Cell membrane	NA	Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;P2Y receptors	PE1	11
+NX_Q15078	Cyclin-dependent kinase 5 activator 1	307	34060	9.44	0	Cell membrane;Perikaryon;Nucleoplasm;Cytoplasmic vesicle;Neuron projection;Perinuclear region;Nucleus	NA	P35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.	Myristoylated. A proper myristoylation signal is essential for the proper distribution of p35.;Phosphorylation at Ser-8 and Thr-138 by CDK5 prevents calpain-mediated proteolysis.;The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo (By similarity).;Ubiquitinated. Degradation of p35 by proteasome results in down-regulation of CDK5 activity. During this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation.	Belongs to the cyclin-dependent kinase 5 activator family.	Alzheimer's disease;CRMPs in Sema3A signaling;Regulation of TP53 Activity through Phosphorylation;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Activated NTRK2 signals through CDK5	PE1	17
+NX_Q15080	Neutrophil cytosol factor 4	339	39032	6.4	0	Membrane;Cytosol;Endosome membrane	Granulomatous disease, chronic, cytochrome-b-positive 3, autosomal recessive	Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.	NA	NA	Phagosome;Osteoclast differentiation;Leukocyte transendothelial migration;Leishmaniasis;Detoxification of Reactive Oxygen Species;VEGFA-VEGFR2 Pathway;ROS and RNS production in phagocytes;Cross-presentation of particulate exogenous antigens (phagosomes);RHO GTPases Activate NADPH Oxidases	PE1	22
+NX_Q15084	Protein disulfide-isomerase A6	440	48121	4.95	0	Cell membrane;Endoplasmic reticulum;Melanosome;Cytosol;Endoplasmic reticulum lumen	NA	May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).	NA	Belongs to the protein disulfide isomerase family.	Protein processing in endoplasmic reticulum;XBP1(S) activates chaperone genes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	2
+NX_Q15102	Platelet-activating factor acetylhydrolase IB subunit gamma	231	25734	6.33	0	Cytoplasm;Cytoskeleton	NA	Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.	NA	Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.	Ether lipid metabolism;Metabolic pathways;COPI-independent Golgi-to-ER retrograde traffic	PE1	19
+NX_Q15109	Advanced glycosylation end product-specific receptor	404	42803	5.83	1	Cell junction;Secreted;Nucleolus;Cell membrane	NA	Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.	NA	NA	Advanced glycosylation endproduct receptor signaling;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation	PE1	6
+NX_Q15111	Inactive phospholipase C-like protein 1	1095	122728	5.46	0	Cytoplasm	NA	Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.	Phosphorylated by the catalytic subunit of PKA. Phosphorylation of Thr-93 resulted in dissociation of PPP1C from PRIP1 (By similarity).	NA	GABAergic synapse	PE1	2
+NX_Q15113	Procollagen C-endopeptidase enhancer 1	449	47972	7.41	0	Golgi apparatus;Cytoplasmic vesicle;Secreted	NA	Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.;C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.	C-terminally processed at multiple positions.	NA	Collagen biosynthesis and modifying enzymes;Crosslinking of collagen fibrils	PE1	7
+NX_Q15116	Programmed cell death protein 1	288	31647	8.25	1	Cell membrane	Systemic lupus erythematosus 2	Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).;The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28951311). The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:28951311). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:22658127, PubMed:25034862, PubMed:25399552).	Ubiquitinated at Lys-233 by the SCF(FBXO38) complex, leading to its proteasomal degradation (PubMed:30487606). Ubiquitinated via 'Lys-48'-linked polyubiquitin chains (PubMed:30487606).;Tyrosine phosphorylated at Tyr-223 (within ITIM motif) and Tyr-248 (ITSM motif) upon ligand binding. Phosphorylation at Tyr-248 promotes the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta.;N-glycosylation at Asn-58 consists of two N-acetylglucosamine units and one fucose (PubMed:28165004). N-glycosylation does not affect binding to nivolumab drug (PubMed:28165004).	NA	Cell adhesion molecules (CAMs);T cell receptor signaling pathway;PD-1 signaling	PE1	2
+NX_Q15118	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	436	49244	8.92	0	Mitochondrion matrix;Mitochondrion;Nucleolus	NA	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.	Phosphorylated by constitutively activated ABL1, FGFR1, FLT3 and JAK2 (in vitro), and this may also occur in cancer cells that express constitutively activated ABL1, FGFR1, FLT3 and JAK2. Phosphorylation at Tyr-243 and Tyr-244 strongly increases kinase activity, while phosphorylation at Tyr-136 has a lesser effect.	Belongs to the PDK/BCKDK protein kinase family.	T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Neurotrophin signaling pathway;Toxoplasmosis;Hepatitis C;Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex	PE1	2
+NX_Q15119	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	407	46154	6.14	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	NA	Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.	NA	Belongs to the PDK/BCKDK protein kinase family.	Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex	PE1	17
+NX_Q15120	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	406	46939	8.46	0	Mitochondrion matrix;Mitochondrion;Nucleolus	Charcot-Marie-Tooth disease, X-linked dominant, 6	Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.	NA	Belongs to the PDK/BCKDK protein kinase family.	Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex	PE1	X
+NX_Q15121	Astrocytic phosphoprotein PEA-15	130	15040	4.93	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.	Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.	NA	RAF/MAP kinase cascade;RAF-independent MAPK1/3 activation	PE1	1
+NX_Q15124	Phosphoglucomutase-like protein 5	567	62225	6.81	0	Adherens junction;Cytoskeleton	NA	Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity.	NA	Belongs to the phosphohexose mutase family.	NA	PE1	9
+NX_Q15125	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	230	26353	7.76	4	Endoplasmic reticulum;Cytoplasmic vesicle;Endoplasmic reticulum membrane;Nucleus envelope	MEND syndrome;Chondrodysplasia punctata 2, X-linked dominant	Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.	NA	Belongs to the EBP family.	Steroid biosynthesis; cholesterol biosynthesis.;Steroid biosynthesis;Metabolic pathways;Cholesterol biosynthesis via desmosterol;Cholesterol biosynthesis via lathosterol	PE1	X
+NX_Q15126	Phosphomevalonate kinase	192	21995	5.56	0	Cytosol	Porokeratosis 1, multiple types	NA	NA	NA	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.;Terpenoid backbone biosynthesis;Metabolic pathways;Peroxisome;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	1
+NX_Q15131	Cyclin-dependent kinase 10	360	41038	9.06	0	Nucleoplasm;Cilium basal body;Midbody;Midbody ring	Al Kaissi syndrome	Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	16
+NX_Q15139	Serine/threonine-protein kinase D1	912	101704	6.16	0	trans-Golgi network;Cytoplasm;Cytosol;Cell membrane	Congenital heart defects and ectodermal dysplasia	Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity).	Phosphorylated at Ser-397 and Ser-401 by MAPK13 during regulation of insulin secretion in pancreatic beta cells (PubMed:19135240). Phosphorylated by DAPK1 (PubMed:17703233). Phosphorylated at Tyr-95 and by ABL at Tyr-463, which primes the kinase in response to oxidative stress, and promotes a second step activating phosphorylation at Ser-738/Ser-742 by PKRD (PubMed:12637538, PubMed:15024053, PubMed:17804414). Phosphorylated on Ser-910 upon S.enterica infection in macrophages (By similarity).;PRKD1 is phosphorylated by DAPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.	Sphingolipid de novo biosynthesis	PE1	14
+NX_Q15147	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	1175	134464	6.47	0	Nucleoplasm;Cytoskeleton	Auriculocondylar syndrome 2	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;Vascular smooth muscle contraction;Wnt signaling pathway;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;Dopaminergic synapse;Long-term depression;GnRH signaling pathway;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Alzheimer's disease;Huntington's disease;Chagas disease (American trypanosomiasis);African trypanosomiasis;Amoebiasis;G alpha (q) signalling events;Synthesis of IP3 and IP4 in the cytosol;PLC beta mediated events	PE1	20
+NX_Q15149	Plectin	4684	531791	5.74	0	Cytoplasm;Focal adhesion;Hemidesmosome;Cytosol;Cytoskeleton	Epidermolysis bullosa simplex, with muscular dystrophy;Epidermolysis bullosa simplex, Ogna type;Epidermolysis bullosa simplex with pyloric atresia;Epidermolysis bullosa simplex with nail dystrophy;Muscular dystrophy, limb-girdle, autosomal recessive 17	Plays a major role in the maintenance of myofiber integrity.;Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle.	Phosphorylated by CDK1; regulates dissociation from intermediate filaments during mitosis.	Belongs to the plakin or cytolinker family.	Caspase-mediated cleavage of cytoskeletal proteins;Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly	PE1	8
+NX_Q15154	Pericentriolar material 1 protein	2024	228544	4.95	0	Centriolar satellite;Cilium basal body;Nucleus membrane;Centrosome;Cytosol;Cytoplasmic granule;Cytoskeleton	NA	Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Involved in the biogenesis of cilia (PubMed:20551181, PubMed:24121310).	Variant Ser-159 is phosphorylated.;Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown (PubMed:29973724). Phosphorylation by DYRK3 promotes disassembly of pericentriolar material (PubMed:29973724).;Ubiquitinated. Undergoes monoubiquitination catalyzed by the E3 ubiquitin-protein ligase MIB1 in proliferating cells, preventing cilia formation (PubMed:24121310). Monoubiquitination by MIB1 is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, resulting in cilia formation initiation (PubMed:24121310).	Belongs to the PCM1 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	8
+NX_Q15155	Nodal modulator 1	1222	134324	5.54	1	Membrane;Endoplasmic reticulum	NA	May antagonize Nodal signaling.	NA	NA	NA	PE1	16
+NX_Q15165	Serum paraoxonase/arylesterase 2	354	39381	5.33	0	Membrane	NA	Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.	The signal sequence is not cleaved.	Belongs to the paraoxonase family.	Metabolic pathways;Synthesis of 5-eicosatetraenoic acids	PE1	7
+NX_Q15166	Serum paraoxonase/lactonase 3	354	39607	5.24	0	Extracellular space	NA	Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. Lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.	The signal sequence is not cleaved.	Belongs to the paraoxonase family.	Metabolic pathways;Synthesis of 5-eicosatetraenoic acids	PE1	7
+NX_Q15170	Transcription elongation factor A protein-like 1	157	18354	11.2	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.	Phosphorylation of Ser-36 and Ser-37 is critical for transcriptional repression.	Belongs to the TFS-II family. TFA subfamily.	NA	PE1	X
+NX_Q15172	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	486	56194	6.28	0	Cytoplasm;Centromere;Nucleus;Cytosol	NA	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Phosphorylated on serine residues.	Belongs to the phosphatase 2A regulatory subunit B56 family.	mRNA surveillance pathway;Oocyte meiosis;Wnt signaling pathway;Dopaminergic synapse;Degradation of beta-catenin by the destruction complex;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Negative regulation of MAPK pathway;RAF activation;Disassembly of the destruction complex and recruitment of AXIN to the membrane;CTLA4 inhibitory signaling;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Platelet sensitization by LDL;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	1
+NX_Q15173	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform	497	57393	6.27	0	Cytoplasm	NA	As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.	Ubiquitinated by E3 CUL3-KLHL15 complex; this modification leads to proteasomal degradation.	Belongs to the phosphatase 2A regulatory subunit B56 family.	mRNA surveillance pathway;Oocyte meiosis;Wnt signaling pathway;Dopaminergic synapse;Degradation of beta-catenin by the destruction complex;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;XBP1(S) activates chaperone genes;Negative regulation of MAPK pathway;RAF activation;Disassembly of the destruction complex and recruitment of AXIN to the membrane;CTLA4 inhibitory signaling;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Platelet sensitization by LDL;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	11
+NX_Q15181	Inorganic pyrophosphatase	289	32660	5.54	0	Cytoplasmic vesicle;Cytoplasm	NA	NA	NA	Belongs to the PPase family.	Oxidative phosphorylation;Cytosolic tRNA aminoacylation;Pyrophosphate hydrolysis	PE1	10
+NX_Q15185	Prostaglandin E synthase 3	160	18697	4.35	0	Nucleoplasm;Cytoplasm;Cytosol	NA	Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).	NA	Belongs to the p23/wos2 family.	Lipid metabolism; prostaglandin biosynthesis.;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Attenuation phase;HSF1 activation;Aryl hydrocarbon receptor signalling;HSP90 chaperone cycle for steroid hormone receptors (SHR);Estrogen-dependent gene expression;ESR-mediated signaling	PE1	12
+NX_Q15195	Plasminogen-like protein A	96	10915	6.11	0	Secreted	NA	May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction (By similarity).	NA	NA	NA	PE2	2
+NX_Q15198	Platelet-derived growth factor receptor-like protein	375	41861	8.75	0	Golgi apparatus;Nucleoplasm;Secreted;Nucleolus	Colorectal cancer	NA	NA	NA	NA	PE1	8
+NX_Q15208	Serine/threonine-protein kinase 38	465	54190	6.7	0	Cytoplasm;Nucleus	NA	Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.	ISGylated.;Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B.;STK38 is phosphorylated by STK3	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	NA	PE1	6
+NX_Q15223	Nectin-1	517	57158	5.77	1	Secreted;Presynaptic cell membrane;Cell membrane	Ectodermal dysplasia, Margarita Island type;Non-syndromic orofacial cleft 7	(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV.;Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.	NA	Belongs to the nectin family.	Cell adhesion molecules (CAMs);Adherens junction;Herpes simplex infection;Adherens junctions interactions;Nectin/Necl trans heterodimerization	PE1	11
+NX_Q15233	Non-POU domain-containing octamer-binding protein	471	54232	9.01	0	Nucleoplasm;Nucleus;Nucleus speckle;Nucleolus	Mental retardation, X-linked, syndromic, 34	DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).	The N-terminus is blocked.	NA	NA	PE1	X
+NX_Q15238	Pregnancy-specific beta-1-glycoprotein 5	335	37713	9	0	Secreted	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall	PE1	19
+NX_Q15256	Receptor-type tyrosine-protein phosphatase R	657	73834	8.62	1	Cytosol;Cell junction;Perinuclear region;Cell membrane	NA	Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).	PTPRR is phosphorylated by MAPK7 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily.	MAPK signaling pathway	PE1	12
+NX_Q15257	Serine/threonine-protein phosphatase 2A activator	358	40668	5.63	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.	NA	Belongs to the PTPA-type PPIase family.	NA	PE1	9
+NX_Q15262	Receptor-type tyrosine-protein phosphatase kappa	1439	162102	5.59	1	Cytoplasmic vesicle;Adherens junction;Cell junction;Cell membrane	NA	Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.	This protein undergoes proteolytic processing.	Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.	EGFR downregulation	PE1	6
+NX_Q15269	Periodic tryptophan protein 2 homolog	919	102452	5.76	0	Cytosol;Nucleolus	NA	NA	NA	Belongs to the WD repeat PWP2 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	21
+NX_Q15270	NK1 transcription factor-related protein 1	411	40659	5.93	0	Nucleus	NA	NA	NA	Belongs to the NK-1 homeobox family.	NA	PE2	4
+NX_Q15274	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	297	30846	5.81	0	NA	NA	Involved in the catabolism of quinolinic acid (QA).	NA	Belongs to the NadC/ModD family.	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.;Nicotinate and nicotinamide metabolism;Metabolic pathways;Nicotinate metabolism	PE1	16
+NX_Q15276	Rab GTPase-binding effector protein 1	862	99290	4.95	0	Cytoplasmic vesicle;Early endosome;Cytoplasm;Recycling endosome	NA	Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity).	Proteolytic cleavage by caspases in apoptotic cells causes loss of endosome fusion activity.	Belongs to the rabaptin family.	Endocytosis;TBC/RABGAPs	PE1	17
+NX_Q15283	Ras GTPase-activating protein 2	850	96614	6.84	0	Cytoplasm;Perinuclear region;Cytoplasmic vesicle	NA	Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).	NA	NA	MAPK signaling pathway;Regulation of RAS by GAPs;Signaling by RAS mutants	PE1	3
+NX_Q15286	Ras-related protein Rab-35	201	23025	8.53	0	Clathrin-coated vesicle;Cell membrane;Clathrin-coated pit;Endosome;Melanosome	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.	Phosphocholinated by L.pneumophila AnkX. Both GDP-bound and GTP-bound forms can be phosphocholinated. Phosphocholination inhibits the GEF activity of DENND1A.;AMPylation at Tyr-77 by L.pneumophila DrrA occurs in the switch 2 region and leads to moderate inactivation of the GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB35 constitutively active.	Belongs to the small GTPase superfamily. Rab family.	RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs;RAB geranylgeranylation	PE1	12
+NX_Q15287	RNA-binding protein with serine-rich domain 1	305	34208	11.85	0	Cytoplasm;Nucleoplasm;Nucleus speckle;Nucleus	NA	Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.	Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro.	Belongs to the splicing factor SR family.	RNA transport;mRNA surveillance pathway;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Regulation of expression of SLITs and ROBOs;RNA Polymerase II Transcription Termination	PE1	16
+NX_Q15291	Retinoblastoma-binding protein 5	538	59153	4.96	0	Nucleoplasm;Nucleus;Nucleolus	NA	In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.	NA	NA	PKMTs methylate histone lysines;Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Neddylation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	1
+NX_Q15293	Reticulocalbin-1	331	38890	4.86	0	Endoplasmic reticulum;Endoplasmic reticulum lumen	NA	May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.	O-glycosylated. O-mannosylated by POMT1 and POMT2 and elongated by POMGNT1.	Belongs to the CREC family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	11
+NX_Q15303	Receptor tyrosine-protein kinase erbB-4	1308	146808	5.98	1	Mitochondrion;Nucleus;Cell membrane	Amyotrophic lateral sclerosis 19	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1.	Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. One subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Ligands trigger phosphorylation at specific tyrosine residues, thereby creating binding sites for scaffold proteins and effectors. Constitutively phosphorylated at a basal level when overexpressed in heterologous systems; ligand binding leads to increased phosphorylation. Phosphorylation at Tyr-1035 is important for interaction with STAT1. Phosphorylation at Tyr-1056 is important for interaction with PIK3R1. Phosphorylation at Tyr-1242 is important for interaction with SHC1. Phosphorylation at Tyr-1188 may also contribute to the interaction with SHC1.;Ubiquitinated. During mitosis, the ERBB4 intracellular domain is ubiquitinated by the APC/C complex and targeted to proteasomal degradation.	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.	ErbB signaling pathway;Calcium signaling pathway;Endocytosis;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;PI3K events in ERBB4 signaling;SHC1 events in ERBB4 signaling;Nuclear signaling by ERBB4;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Downregulation of ERBB4 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling;Estrogen-dependent gene expression;Long-term potentiation	PE1	2
+NX_Q15306	Interferon regulatory factor 4	451	51772	6.39	0	Nucleoplasm;Cytosol;Nucleus	Multiple myeloma	Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).	Phosphorylation by ROCK2 regulates IL-17 and IL-21 production.;IRF4 is phosphorylated by ROCK2 (Phosphoserine:PTM-0253)	Belongs to the IRF family.	Interferon gamma signaling;Interferon alpha/beta signaling;Interleukin-4 and Interleukin-13 signaling	PE1	6
+NX_Q15311	RalA-binding protein 1	655	76063	5.68	0	Membrane;Cytoplasmic vesicle;Cytosol;Nucleus membrane	NA	Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.	NA	NA	Pathways in cancer;Pancreatic cancer;Rho GTPase cycle	PE1	18
+NX_Q15319	POU domain, class 4, transcription factor 3	338	37052	9.16	0	Nucleoplasm;Cytoplasm;Nucleus	Deafness, autosomal dominant, 15	Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity).	NA	Belongs to the POU transcription factor family. Class-4 subfamily.	NA	PE1	5
+NX_Q15323	Keratin, type I cuticular Ha1	416	47237	4.84	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q15326	Zinc finger MYND domain-containing protein 11	602	70963	8.83	0	Nucleoplasm;Nucleus;Chromosome	Mental retardation, autosomal dominant 30	Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.;(Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction.	Sumoylated following its interaction with PIAS1 and UBE2I.;Ubiquitinated, leading to proteasomal degradation.	NA	NA	PE1	10
+NX_Q15327	Ankyrin repeat domain-containing protein 1	319	36252	7.12	0	Nucleoplasm;Nucleus;Nucleolus	Total anomalous pulmonary venous return	May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.	NA	NA	PPARA activates gene expression	PE1	10
+NX_Q15329	Transcription factor E2F5	346	37610	4.94	0	Nucleoplasm;Nucleus;Nucleolus;Cytoplasmic vesicle	NA	Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.	NA	Belongs to the E2F/DP family.	Cell cycle;TGF-beta signaling pathway;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;G0 and Early G1;G1/S-Specific Transcription;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry;Cyclin D associated events in G1;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	PE1	8
+NX_Q15334	Lethal(2) giant larvae protein homolog 1	1064	115418	5.87	0	trans-Golgi network membrane;Golgi apparatus membrane;Early endosome membrane;Axon;Cytoskeleton	NA	Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.	Phosphorylated at least at Ser-663 by PRKCI.	Belongs to the WD repeat L(2)GL family.	Tight junction	PE1	17
+NX_Q15345	Leucine-rich repeat-containing protein 41	812	88650	8.75	0	Nucleoplasm;Nucleus	NA	Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	1
+NX_Q15349	Ribosomal protein S6 kinase alpha-2	733	83239	8.82	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.	N-terminal myristoylation results in an activated kinase in the absence of added growth factors.;Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	MAPK signaling pathway;Oocyte meiosis;mTOR signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Progesterone-mediated oocyte maturation;Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK;ERK/MAPK targets;CREB phosphorylation	PE1	6
+NX_Q15361	Transcription termination factor 1	905	103051	9.41	0	Nucleoplasm;Nucleolus;Nucleus	NA	Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.	NA	NA	NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Termination;Surfactant metabolism;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	PE1	9
+NX_Q15363	Transmembrane emp24 domain-containing protein 2	201	22761	5.08	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane;cis-Golgi network membrane;Golgi stack membrane;COPI-coated vesicle membrane;Cytoplasmic vesicle membrane;Cytoplasmic vesicle	NA	Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.	NA	Belongs to the EMP24/GP25L family.	Pre-NOTCH Processing in Golgi;COPII-mediated vesicle transport;Cargo concentration in the ER;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	12
+NX_Q15365	Poly(rC)-binding protein 1	356	37498	6.66	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).	Phosphorylated; lowers poly(rC)-binding activity.;PCBP1 is phosphorylated by AKT2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Spliceosome;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA	PE1	2
+NX_Q15366	Poly(rC)-binding protein 2	365	38580	6.33	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509).;(Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).	Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.;(Microbial infection) Proteolyticaly cleaved by picornavirus proteinase 3CD.	NA	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;Negative regulators of DDX58/IFIH1 signaling	PE1	12
+NX_Q15369	Elongin-C	112	12473	4.74	0	Cytoplasmic vesicle;Nucleolus;Cell junction;Nucleus	NA	SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).;The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.	NA	Belongs to the SKP1 family.	Ubiquitin mediated proteolysis;Pathways in cancer;Renal cell carcinoma;Vif-mediated degradation of APOBEC3G;Antigen processing: Ubiquitination &amp; Proteasome degradation;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes;Neddylation;Regulation of expression of SLITs and ROBOs	PE1	8
+NX_Q15370	Elongin-B	118	13133	4.73	0	Nucleus	NA	The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.;SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).	NA	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Pathways in cancer;Renal cell carcinoma;Vif-mediated degradation of APOBEC3G;Antigen processing: Ubiquitination &amp; Proteasome degradation;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes;Neddylation;Regulation of expression of SLITs and ROBOs	PE1	16
+NX_Q15375	Ephrin type-A receptor 7	998	112097	5.58	1	Cell membrane	NA	Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.	Phosphorylated.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	6
+NX_Q15382	GTP-binding protein Rheb	184	20497	5.65	0	Golgi apparatus membrane;Endomembrane system;Endoplasmic reticulum membrane;Cytosol	NA	Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.	Farnesylation is important for efficiently activating mTORC1-mediated signaling.;Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation.	Belongs to the small GTPase superfamily. Rheb family.	mTOR signaling pathway;Insulin signaling pathway;Macroautophagy;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;mTOR signalling;mTORC1-mediated signalling;Regulation of PTEN gene transcription	PE1	7
+NX_Q15386	Ubiquitin-protein ligase E3C	1083	123923	6.27	0	Nucleoplasm;Mitochondrion;Nucleus;Cell membrane	NA	E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.	NA	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	7
+NX_Q15388	Mitochondrial import receptor subunit TOM20 homolog	145	16298	8.81	1	Mitochondrion outer membrane;Mitochondrion	NA	Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	Belongs to the Tom20 family.	Mitochondrial protein import;Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases	PE1	1
+NX_Q15389	Angiopoietin-1	498	57513	6.3	0	Secreted	NA	Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.	Glycosylated.	NA	Rheumatoid arthritis;RAF/MAP kinase cascade;Tie2 Signaling	PE1	8
+NX_Q15390	Mitochondrial fission regulator 1	333	37000	9.1	0	Cytosol;Mitochondrion	NA	May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity).	NA	Belongs to the MTFR1 family.	NA	PE1	8
+NX_Q15391	P2Y purinoceptor 14	338	38971	9.54	7	Cell membrane	NA	Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;P2Y receptors	PE2	3
+NX_Q15392	Delta(24)-sterol reductase	516	60101	8.42	1	Endoplasmic reticulum membrane;Golgi apparatus membrane	Desmosterolosis	Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:25637936, PubMed:22178193). In addition to its cholesterol-synthesizing activity, can protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892).	NA	Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Steroid biosynthesis; cholesterol biosynthesis.;Steroid biosynthesis;Metabolic pathways;Cholesterol biosynthesis via desmosterol;Cholesterol biosynthesis via lathosterol	PE1	1
+NX_Q15393	Splicing factor 3B subunit 3	1217	135577	5.13	0	Nucleoplasm;Nucleus;Nucleolus	NA	Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).	NA	Belongs to the RSE1 family.	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	16
+NX_Q15397	Pumilio homolog 3	648	73584	9.65	0	Nucleoplasm;Nucleolus;Chromosome	NA	Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity).	NA	NA	NA	PE1	9
+NX_Q15398	Disks large-associated protein 5	846	95115	9.11	0	Cytoplasm;Centriolar satellite;Cytosol;Spindle;Nucleus	NA	Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.	Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.;Ubiquitinated, leading to its degradation.	Belongs to the SAPAP family.	NOTCH3 Intracellular Domain Regulates Transcription	PE1	14
+NX_Q15399	Toll-like receptor 1	786	90291	6.62	1	Golgi apparatus;Phagosome membrane;Membrane raft;Cell membrane	NA	Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.	NA	Belongs to the Toll-like receptor family.	Toll-like receptor signaling pathway;Tuberculosis;ER-Phagosome pathway;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);Toll Like Receptor TLR1:TLR2 Cascade;Beta defensins;Regulation of TLR by endogenous ligand	PE1	4
+NX_Q15404	Ras suppressor protein 1	277	31540	8.57	0	Cytoplasmic vesicle	NA	Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.	NA	NA	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	PE1	10
+NX_Q15406	Nuclear receptor subfamily 6 group A member 1	480	54383	5.87	0	Nucleoplasm;Cytosol;Centrosome;Nucleus	NA	Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).	NA	Belongs to the nuclear hormone receptor family. NR6 subfamily.	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;Nuclear Receptor transcription pathway	PE1	9
+NX_Q15413	Ryanodine receptor 3	4870	552042	5.47	7	Microsome membrane;Membrane;Sarcoplasmic reticulum;Cytoplasmic vesicle;Sarcoplasmic reticulum membrane	NA	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling.	NA	Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily.	Calcium signaling pathway;Salivary secretion;Alzheimer's disease;Stimuli-sensing channels;Ion homeostasis	PE1	15
+NX_Q15415	RNA-binding motif protein, Y chromosome, family 1 member F/J	496	55728	9.89	0	Nucleus	NA	RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.	NA	NA	NA	PE1	Y
+NX_Q15417	Calponin-3	329	36414	5.69	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	NA	Belongs to the calponin family.	NA	PE1	1
+NX_Q15418	Ribosomal protein S6 kinase alpha-1	735	82723	7.68	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).	Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1.;N-terminal myristoylation results in an activated kinase in the absence of added growth factors.;RPS6KA1 is phosphorylated by MAPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	MAPK signaling pathway;Oocyte meiosis;mTOR signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Progesterone-mediated oocyte maturation;Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK;ERK/MAPK targets;CREB phosphorylation	PE1	1
+NX_Q15424	Scaffold attachment factor B1	915	102642	5.32	0	Nucleoplasm;Nucleus	NA	Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation.	Sumoylated by PIAS1 with SUMO1 and SUMO2/3, desumoylated by SENP1. Sumoylation is required for transcriptional repressor activity.	NA	SUMOylation of transcription cofactors	PE1	19
+NX_Q15427	Splicing factor 3B subunit 4	424	44386	8.55	0	Nucleus speckle;Nucleus	Acrofacial dysostosis 1, Nager type	Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).	NA	Belongs to the SF3B4 family.	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	1
+NX_Q15428	Splicing factor 3A subunit 2	464	49256	9.65	0	Nucleoplasm;Nucleus	NA	Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29361316, PubMed:29360106, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106).	NA	Belongs to the SF3A2 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	19
+NX_Q15431	Synaptonemal complex protein 1	976	114192	5.78	0	Centromere;Nucleus;Chromosome	NA	Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility.	NA	NA	Meiotic synapsis	PE1	1
+NX_Q15434	RNA-binding motif, single-stranded-interacting protein 2	407	43959	9.15	0	Nucleoplasm;Nucleolus;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	12
+NX_Q15435	Protein phosphatase 1 regulatory subunit 7	360	41564	4.84	0	Nucleolus;Nucleus	NA	Regulatory subunit of protein phosphatase 1.	NA	Belongs to the SDS22 family.	NA	PE1	2
+NX_Q15436	Protein transport protein Sec23A	765	86161	6.64	0	Endoplasmic reticulum membrane;Nucleoplasm;COPII-coated vesicle membrane;Cytoplasmic vesicle;Cytosol	Craniolenticulosutural dysplasia	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity).	NA	Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Protein processing in endoplasmic reticulum;MHC class II antigen presentation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;Cargo concentration in the ER	PE1	14
+NX_Q15437	Protein transport protein Sec23B	767	86479	6.43	0	COPII-coated vesicle membrane;Cytosol;Endoplasmic reticulum membrane;Cytoplasmic vesicle	Cowden syndrome 7;Anemia, congenital dyserythropoietic, 2	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.	NA	Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Protein processing in endoplasmic reticulum	PE1	20
+NX_Q15438	Cytohesin-1	398	46413	5.41	0	Cell membrane;Adherens junction;Nucleolus;Nucleoplasm;Tight junction;Cytosol	NA	Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.	Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation.	NA	Intra-Golgi traffic	PE1	17
+NX_Q15459	Splicing factor 3A subunit 1	793	88886	5.15	0	Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277).	NA	NA	Spliceosome;mRNA Splicing - Major Pathway	PE1	22
+NX_Q15464	SH2 domain-containing adapter protein B	509	55042	9.1	0	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	NA	Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.	Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.;SHB is phosphorylated by FGFR1 (Phosphotyrosine:PTM-0255)	NA	VEGFA-VEGFR2 Pathway	PE1	9
+NX_Q15465	Sonic hedgehog protein	462	49607	8.1	0	Cell membrane	Triphalangeal thumb-polysyndactyly syndrome;Preaxial polydactyly 2;Hypoplasia or aplasia of tibia with polydactyly;Solitary median maxillary central incisor;Laurin-Sandrow syndrome;Holoprosencephaly 3;Microphthalmia, isolated, with coloboma, 5	Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).;Sonic hedgehog protein N-product: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (PubMed:24863049). Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (PubMed:10753901). In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (PubMed:10753901).	Sonic hedgehog protein N-product: The lipidated N- and C-terminal peptides of ShhNp can be cleaved (shedding)(PubMed:24522195). The N-terminal palmitoylated peptide is cleaved at the Cardin-Weintraub (CW) motif site (PubMed:24522195). The cleavage reduced the interactions with heparan sulfate. The cleavage is enhanced by SCUBE2 (PubMed:24522195, PubMed:23118222).;Sonic hedgehog protein N-product: N-palmitoylation by HHAT of ShhN is required for sonic hedgehog protein N-product multimerization and full activity (By similarity). It is a prerequisite for the membrane-proximal positioning and the subsequent shedding of this N-terminal peptide (PubMed:24522195).;Sonic hedgehog protein: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (ShhN) (By similarity). Cholesterylation is required for the sonic hedgehog protein N-product targeting to lipid rafts and multimerization (PubMed:24522195, PubMed:26875496). ShhN is the active species in both local and long-range signaling, whereas the C-product (ShhC) is degraded in the reticulum endoplasmic (By similarity).	Belongs to the hedgehog family.	Hedgehog signaling pathway;Pathways in cancer;Basal cell carcinoma;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Hedgehog 'on' state;Class B/2 (Secretin family receptors);Activation of SMO;Release of Hh-Np from the secreting cell;Ligand-receptor interactions;HHAT G278V abrogates palmitoylation of Hh-Np	PE1	7
+NX_Q15466	Nuclear receptor subfamily 0 group B member 2	257	28058	8.28	0	Cytoplasm;Nucleus	Obesity	Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity).	Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.	Belongs to the nuclear hormone receptor family. NR0 subfamily.	Bile secretion;Nuclear Receptor transcription pathway	PE1	1
+NX_Q15468	SCL-interrupting locus protein	1287	142955	6.01	0	Cytosol;Cell membrane;Centriole	Microcephaly 7, primary, autosomal recessive	Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124).	Phosphorylated following the activation of the mitotic checkpoint.;Ubiquitinated.	NA	NA	PE1	1
+NX_Q15475	Homeobox protein SIX1	284	32210	9.24	0	Nucleoplasm;Cytoplasm;Nucleolus;Nucleus	Deafness, autosomal dominant, 23;Branchiootic syndrome 3	Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.	Ubiquitinated by the anaphase promoting complex (APC), leading to its proteasomal degradation.;Phosphorylated during interphase; becomes hyperphosphorylated during mitosis. Hyperphosphorylation impairs binding to promoter elements.	Belongs to the SIX/Sine oculis homeobox family.	NA	PE1	14
+NX_Q15477	Helicase SKI2W	1246	137755	5.72	0	Cytoplasm;Nucleoplasm;Nucleus	Trichohepatoenteric syndrome 2	Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).	NA	Belongs to the helicase family. SKI2 subfamily.	RNA degradation;Association of TriC/CCT with target proteins during biosynthesis;mRNA decay by 3' to 5' exoribonuclease	PE1	6
+NX_Q15485	Ficolin-2	313	34001	6.31	0	Secreted	NA	May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.	NA	Belongs to the ficolin lectin family.	Initial triggering of complement;Lectin pathway of complement activation;Ficolins bind to repetitive carbohydrate structures on the target cell surface	PE1	9
+NX_Q15486	Putative inactive beta-glucuronidase-like protein SMA3	140	15381	5.71	0	NA	NA	NA	NA	Belongs to the glycosyl hydrolase 2 family.	NA	PE5	5
+NX_Q15493	Regucalcin	299	33253	5.89	0	Nucleoplasm;Cytoplasm	NA	Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).	NA	Belongs to the SMP-30/CGR1 family.	Pentose phosphate pathway;Ascorbate and aldarate metabolism;Metabolic pathways	PE1	X
+NX_Q15506	Sperm surface protein Sp17	151	17406	4.76	0	Membrane;Cytoplasmic vesicle	NA	Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).	NA	NA	NA	PE1	11
+NX_Q15513	Protein SPHAR	63	7515	8.46	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q15517	Corneodesmosin	529	51522	8.69	0	Secreted	Peeling skin syndrome 1;Hypotrichosis 2	Important for the epidermal barrier integrity.	NA	NA	Formation of the cornified envelope	PE1	6
+NX_Q15526	Surfeit locus protein 1	300	33331	9.64	2	Mitochondrion inner membrane	Charcot-Marie-Tooth disease 4K;Leigh syndrome	Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.	NA	Belongs to the SURF1 family.	Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	9
+NX_Q15527	Surfeit locus protein 2	256	29648	9.33	0	Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the SURF2 family.	NA	PE1	9
+NX_Q15528	Mediator of RNA polymerase II transcription subunit 22	200	22221	4.56	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 22 family.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	9
+NX_Q15532	Protein SSXT	418	45929	5.95	0	Nucleoplasm;Cytosol;Nucleus	NA	Function in nuclear receptor coactivation.;Function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).;Appears to function synergistically with RBM14 as a transcriptional coactivator.	NA	Belongs to the SS18 family.	NA	PE1	18
+NX_Q15542	Transcription initiation factor TFIID subunit 5	800	86830	5.4	0	Nucleoplasm;Nucleus	NA	TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed.	NA	Belongs to the WD repeat TAF5 family.	Basal transcription factors;Herpes simplex infection;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA polymerase II transcribes snRNA genes;Regulation of TP53 Activity through Phosphorylation	PE1	10
+NX_Q15543	Transcription initiation factor TFIID subunit 13	124	14287	4.72	0	Nucleoplasm;Nucleus;Nucleolus	Mental retardation, autosomal recessive 60	Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells.	NA	Belongs to the TAF13 family.	Basal transcription factors;Herpes simplex infection;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA polymerase II transcribes snRNA genes;Regulation of TP53 Activity through Phosphorylation	PE1	1
+NX_Q15544	Transcription initiation factor TFIID subunit 11	211	23307	4.78	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).	NA	Belongs to the TAF11 family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA polymerase II transcribes snRNA genes;Regulation of TP53 Activity through Phosphorylation	PE1	6
+NX_Q15545	Transcription initiation factor TFIID subunit 7	349	40259	5.07	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).	Phosphorylated by CIITA. Phosphorylation at Ser-264 by TAF1 in early G1 phase disrupts binding to TAF1.	Belongs to the TAF7 family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation	PE1	5
+NX_Q15546	Monocyte to macrophage differentiation factor	238	27667	9.09	7	Cytoplasmic vesicle;Lysosome membrane;Late endosome membrane	NA	Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion.	NA	Belongs to the ADIPOR family.	NA	PE2	17
+NX_Q15554	Telomeric repeat-binding factor 2	542	59594	9.38	0	Nucleoplasm;Telomere;Nucleus	NA	Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.	Phosphorylated upon DNA damage, most probably by ATM. Phosphorylated TERF2 is not bound to telomeric DNA, and rapidly localizes to damage sites.;Methylated by PRMT1 at multiple arginines within the N-terminal Arg-rich region. Methylation may control association with telomeres.	NA	Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine	PE1	16
+NX_Q15555	Microtubule-associated protein RP/EB family member 2	327	37031	5.36	0	Nucleoplasm;Cytoskeleton	Skin creases, congenital symmetric circumferential, 2	May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).	NA	Belongs to the MAPRE family.	NA	PE1	18
+NX_Q15560	Transcription elongation factor A protein 2	299	33601	9.32	0	Nucleoplasm;Centrosome;Nucleus	NA	Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.	NA	Belongs to the TFS-II family.	NA	PE1	20
+NX_Q15561	Transcriptional enhancer factor TEF-3	434	48329	6.88	0	Nucleoplasm;Nucleus	NA	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.	NA	NA	YAP1- and WWTR1 (TAZ)-stimulated gene expression;RUNX3 regulates YAP1-mediated transcription	PE1	12
+NX_Q15562	Transcriptional enhancer factor TEF-4	447	49243	6.06	0	Nucleoplasm;Nucleus	NA	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.	NA	NA	YAP1- and WWTR1 (TAZ)-stimulated gene expression;RUNX3 regulates YAP1-mediated transcription	PE1	19
+NX_Q15569	Dual specificity testis-specific protein kinase 1	626	67684	8.44	0	NA	NA	Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).	Autophosphorylated on serine and tyrosine residues.	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	PE1	9
+NX_Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	869	95213	8.91	0	Nucleoplasm;Nucleus;Nucleolus	NA	Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.	NA	NA	NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;SIRT1 negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression	PE1	16
+NX_Q15573	TATA box-binding protein-associated factor RNA polymerase I subunit A	450	52676	9.15	0	Nucleoplasm;Nucleus	NA	Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.	NA	NA	NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;SIRT1 negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression	PE1	1
+NX_Q15582	Transforming growth factor-beta-induced protein ig-h3	683	74681	7.62	0	Extracellular matrix;Secreted	Corneal dystrophy, Groenouw type 1;Corneal dystrophy, epithelial basement membrane;Corneal dystrophy, Avellino type;Corneal dystrophy, lattice type 3A;Corneal dystrophy, Reis-Bucklers type;Corneal dystrophy, Thiel-Behnke type;Corneal dystrophy, lattice type 1	Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).	The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain.;Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; these residues may be required for binding to calcium (PubMed:18450759). According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833).	NA	Amyloid fiber formation	PE1	5
+NX_Q15583	Homeobox protein TGIF1	401	43013	9.17	0	Nucleoplasm;Nucleus	Holoprosencephaly 4	Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.	NA	Belongs to the TALE/TGIF homeobox family.	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity	PE1	18
+NX_Q15596	Nuclear receptor coactivator 2	1464	159157	6.19	0	Nucleoplasm;Nucleus	NA	Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).	NA	Belongs to the SRC/p160 nuclear receptor coactivator family.	HATs acetylate histones;PPARA activates gene expression;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Endogenous sterols;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Recycling of bile acids and salts;Synthesis of bile acids and bile salts;Estrogen-dependent gene expression;SUMOylation of transcription cofactors	PE1	8
+NX_Q15599	Na(+)/H(+) exchange regulatory cofactor NHE-RF2	337	37414	7.8	0	Apical cell membrane;Endomembrane system;Nucleus;Cell membrane	NA	Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus.	NA	NA	Aldosterone-regulated sodium reabsorption	PE1	16
+NX_Q155Q3	Dixin	683	77478	5.85	0	Stress fiber;Cytoplasm;Cytosol;Focal adhesion	NA	Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.	Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation.;Phosphorylated on tyrosine and serine residues.	Belongs to the DIXDC1 family.	NA	PE1	11
+NX_Q15612	Olfactory receptor 1Q1	314	35598	9.12	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q15615	Olfactory receptor 4D1	310	35240	8.74	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	17
+NX_Q15617	Olfactory receptor 8G1	311	34904	8.37	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q15619	Olfactory receptor 1C1	314	35042	8.18	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q15620	Olfactory receptor 8B8	311	34482	8.28	7	Cell membrane	NA	Odorant receptor (Potential). May be involved in taste perception.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q15622	Olfactory receptor 7A5	319	35579	8.33	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_Q15628	Tumor necrosis factor receptor type 1-associated DEATH domain protein	312	34247	5.94	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.	NA	NA	Apoptosis;RIG-I-like receptor signaling pathway;Adipocytokine signaling pathway;Tuberculosis;Hepatitis C;TNFR1-induced proapoptotic signaling;Caspase activation via Death Receptors in the presence of ligand;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TNF signaling;Regulation of necroptotic cell death;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway	PE1	16
+NX_Q15629	Translocating chain-associated membrane protein 1	374	43072	9.65	8	Endoplasmic reticulum membrane	NA	Stimulatory or required for the translocation of secretory proteins across the ER membrane.	NA	Belongs to the TRAM family.	Protein processing in endoplasmic reticulum;SRP-dependent cotranslational protein targeting to membrane	PE1	8
+NX_Q15631	Translin	228	26183	6.01	0	Endoplasmic reticulum;Nucleoplasm;Cytoplasm;Nucleus	NA	Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.;DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.	NA	Belongs to the translin family.	Small interfering RNA (siRNA) biogenesis	PE1	2
+NX_Q15633	RISC-loading complex subunit TARBP2	366	39039	6.11	0	Cytoplasm;Nucleoplasm;Perinuclear region;Nucleus	NA	(Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs (PubMed:2011739, PubMed:11438532, PubMed:12475984). This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha (PubMed:11438532). May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR (PubMed:12475984). Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system (PubMed:30626973).;Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.	NA	Belongs to the TARBP2 family.	MicroRNA (miRNA) biogenesis;Small interfering RNA (siRNA) biogenesis	PE1	12
+NX_Q15637	Splicing factor 1	639	68330	9.07	0	Nucleoplasm;Nucleus	NA	Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.	Is phosphorylated on Ser-463.;Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly.	Belongs to the BBP/SF1 family.	mRNA Splicing - Major Pathway	PE1	11
+NX_Q15642	Cdc42-interacting protein 4	601	68352	5.55	0	Golgi apparatus;Cell cortex;Cell membrane;Nucleoplasm;Phagocytic cup;Lysosome;Cytoplasmic vesicle;Perinuclear region;Cytoskeleton	NA	Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.	Tyrosine phosphorylated. Also phosphorylated by PKA.	Belongs to the FNBP1 family.	Insulin signaling pathway;Rho GTPase cycle;Clathrin-mediated endocytosis	PE1	19
+NX_Q15643	Thyroid receptor-interacting protein 11	1979	227586	5.18	0	Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment membrane;cis-Golgi network membrane;Nucleoplasm;Cytoskeleton	Odontochondrodysplasia;Achondrogenesis 1A	Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription.	NA	NA	Intraflagellar transport;Intra-Golgi traffic	PE1	14
+NX_Q15645	Pachytene checkpoint protein 2 homolog	432	48551	5.73	0	Nucleoplasm	Mosaic variegated aneuploidy syndrome 3	Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959).	NA	Belongs to the AAA ATPase family. PCH2 subfamily.	NA	PE1	5
+NX_Q15646	2'-5'-oligoadenylate synthase-like protein	514	59226	7.96	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleolus	NA	Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.	NA	Belongs to the 2-5A synthase family.	Interferon gamma signaling;Interferon alpha/beta signaling;OAS antiviral response	PE1	12
+NX_Q15648	Mediator of RNA polymerase II transcription subunit 1	1581	168478	8.88	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).	Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus.;MED1 is phosphorylated by MAPK3	Belongs to the Mediator complex subunit 1 family.	Generic Transcription Pathway;PPARA activates gene expression;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Nuclear Receptor transcription pathway;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Estrogen-dependent gene expression	PE1	17
+NX_Q15649	Zinc finger HIT domain-containing protein 3	155	17607	5.51	0	Cytoplasm;Mitochondrion;Nucleus	PEHO syndrome	NA	NA	NA	NA	PE1	17
+NX_Q15650	Activating signal cointegrator 1	581	66146	8.05	0	Nucleoplasm;Cytosol;Centrosome;Nucleus	Muscular dystrophy, congenital, Davignon-Chauveau type;Spinal muscular atrophy with congenital bone fractures 1	Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity).	Phosphorylated by NEK6.;Polyufmylated by the UFM1-conjugating system composed of the enzymes UBA5, UFC1 and UFL1. Deufmylated by the protease UFSP2. Ufmylation of TRIP4 is promoted by ligand-bound nuclear receptors that compete with UFSP2 for interaction with TRIP4. Nuclear receptors-induced ufmylation promotes the recruitment of additional transcriptional coactivators like EP300 and NCOA1 and therefore the assembly of a coactivator complex facilitating nuclear receptor-mediated transcription.;TRIP4 is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	15
+NX_Q15651	High mobility group nucleosome-binding domain-containing protein 3	99	10666	9.66	0	Nucleoplasm;Cytosol;Nucleus	NA	Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).	NA	Belongs to the HMGN family.	NA	PE1	6
+NX_Q15652	Probable JmjC domain-containing histone demethylation protein 2C	2540	284525	7.95	0	Nucleoplasm;Cytosol;Nucleus	NA	Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).	NA	Belongs to the JHDM2 histone demethylase family.	Factors involved in megakaryocyte development and platelet production	PE1	10
+NX_Q15653	NF-kappa-B inhibitor beta	356	37771	4.7	0	Cytoplasm;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.	Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.;NFKBIB is phosphorylated by CHUK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the NF-kappa-B inhibitor family.	Chemokine signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Neurotrophin signaling pathway;Adipocytokine signaling pathway;Shigellosis;Leishmaniasis;Toxoplasmosis;Measles;Influenza A;Herpes simplex infection;Activation of NF-kappaB in B cells;RIP-mediated NFkB activation via ZBP1;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation	PE1	19
+NX_Q15654	Thyroid receptor-interacting protein 6	476	50288	7.19	0	Cytoplasm;Cell membrane;Focal adhesion;Cytosol;Nucleus;Cytoskeleton	NA	Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.	Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.	Belongs to the zyxin/ajuba family.	NOD-like receptor signaling pathway	PE1	7
+NX_Q15661	Tryptase alpha/beta-1	275	30515	6.62	0	Secreted	NA	Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.;Cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).	NA	Belongs to the peptidase S1 family. Tryptase subfamily.	Activation of Matrix Metalloproteinases	PE1	16
+NX_Q15669	Rho-related GTP-binding protein RhoH	191	21331	9.17	0	Golgi apparatus;Cytoplasm;Cell membrane;Cytoplasmic vesicle	Epidermodysplasia verruciformis 4	Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils.	Phosphorylated on tyrosine by LCK. Phosphorylated by FYN. Phosphorylation enhances the interactions with ZAP70 and SYK and is critical for its function in thymocyte development (By similarity).	Belongs to the small GTPase superfamily. Rho family.	Leukocyte transendothelial migration;Rho GTPase cycle	PE1	4
+NX_Q15672	Twist-related protein 1	202	20954	9.48	0	Nucleus	Saethre-Chotzen syndrome;Craniosynostosis 1;Robinow-Sorauf syndrome;Sweeney-Cox syndrome	Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).	NA	NA	Interleukin-4 and Interleukin-13 signaling;Regulation of RUNX2 expression and activity;Transcriptional regulation by RUNX2	PE1	7
+NX_Q15678	Tyrosine-protein phosphatase non-receptor type 14	1187	135261	8.53	0	Nucleoplasm;Cytoplasm;Nucleus;Cytoskeleton	Choanal atresia and lymphedema	Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.	Ubiquitinated by the ECS (Elongin BC-CUL2/5-SOCS-box protein)/LRR1 E3 ligase complex and subsequently targeted to proteasomal degradation.	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.	Interleukin-37 signaling	PE1	1
+NX_Q15691	Microtubule-associated protein RP/EB family member 1	268	29999	5.02	0	Golgi apparatus;Centriolar satellite;Centrosome;Cytosol;Cytoskeleton	NA	Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:12388762). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). May play a role in cell migration (By similarity).	NA	Belongs to the MAPRE family.	Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Recruitment of NuMA to mitotic centrosomes;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2	PE1	20
+NX_Q15695	Putative U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1	479	57643	9.44	0	Nucleus	NA	NA	NA	NA	NA	PE5	5
+NX_Q15696	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2	482	58045	9.75	0	Nucleus	NA	Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.	Phosphorylated in the RS domain by SRPK1.;ZRSR2 is phosphorylated by SRPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	mRNA Splicing - Minor Pathway	PE1	X
+NX_Q15697	Zinc finger protein 174	407	46455	9.66	0	Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	16
+NX_Q15699	ALX homeobox protein 1	326	36961	8.8	0	Golgi apparatus;Nucleoplasm;Nucleus	Frontonasal dysplasia 3	Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:9753625, PubMed:8756334). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509).	Acetylated at Lys-131 by EP300; increases interaction with EP300 and stimulates ALX1 transcriptional activity.	Belongs to the paired homeobox family.	NA	PE1	12
+NX_Q156A1	Ataxin-8	80	10272	5.28	0	Nucleus	Spinocerebellar ataxia 8	NA	NA	NA	NA	PE1	13
+NX_Q15700	Disks large homolog 2	870	97552	6.03	0	Cell membrane;Perikaryon;Membrane;Postsynaptic density;Synapse;Cytoplasmic vesicle;Axon	NA	Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).	Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.	Belongs to the MAGUK family.	RAF/MAP kinase cascade;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;Neurexins and neuroligins;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	11
+NX_Q15714	TSC22 domain family protein 1	1073	109677	5.38	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.	NA	Belongs to the TSC-22/Dip/Bun family.	NA	PE1	13
+NX_Q15717	ELAV-like protein 1	326	36092	9.23	0	Cytoplasm;Stress granule;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010).	Phosphorylated by MAPKAPK2 (PubMed:14517288). Phosphorylated by PRKCD (PubMed:18285462).;Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.	Belongs to the RRM elav family.	mRNA Splicing - Major Pathway;HuR (ELAVL1) binds and stabilizes mRNA	PE1	19
+NX_Q15722	Leukotriene B4 receptor 1	352	37557	11.11	7	Cell membrane	NA	Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.	Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.;LTB4R is phosphorylated by GRK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Leukotriene receptors	PE1	14
+NX_Q15723	ETS-related transcription factor Elf-2	593	63967	6.15	0	Nucleoplasm;Nucleus	NA	Transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.;May function in repression of RUNX1-mediated transactivation.	NA	Belongs to the ETS family.	RUNX1 regulates transcription of genes involved in BCR signaling	PE1	4
+NX_Q15726	Metastasis-suppressor KiSS-1	138	14705	10.17	0	Cytoplasmic vesicle;Secreted	Hypogonadotropic hypogonadism 13 with or without anosmia	Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.	Processed by MMP2 and MMP9.	Belongs to the KISS1 family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	1
+NX_Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	1006	107197	9.22	0	Cytoplasm;Cytosol;Nucleolus	NA	Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity).	NA	Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the plasma membrane;Synthesis of IP2, IP, and Ins in the cytosol;Synthesis of IP3 and IP4 in the cytosol	PE1	22
+NX_Q15738	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	373	41900	8.16	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Lipid droplet	CK syndrome;Congenital hemidysplasia with ichthyosiform erythroderma and limb defects	Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis.	NA	Belongs to the 3-beta-HSD family.	Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.;Steroid biosynthesis;Metabolic pathways;Cholesterol biosynthesis	PE1	X
+NX_Q15742	NGFI-A-binding protein 2	525	56594	6.5	0	Nucleoplasm;Cytosol;Nucleus	NA	Lacks repression ability (By similarity).;Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.	Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.	Belongs to the NAB family.	NA	PE1	12
+NX_Q15743	Ovarian cancer G-protein coupled receptor 1	365	41077	7.87	7	Cell membrane	Amelogenesis imperfecta, hypomaturation type, 2A6	Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (q) signalling events;Class A/1 (Rhodopsin-like receptors)	PE1	14
+NX_Q15744	CCAAT/enhancer-binding protein epsilon	281	30603	9.13	0	Nucleoplasm;Cytosol;Nucleus	Specific granule deficiency 1	Transcriptional activator (PubMed:26019275). C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588).	Phosphorylated.	Belongs to the bZIP family. C/EBP subfamily.	Transcriptional regulation of granulopoiesis	PE1	14
+NX_Q15746	Myosin light chain kinase, smooth muscle	1914	210715	5.85	0	Cytoplasm;Cleavage furrow;Cell membrane;Stress fiber;Lamellipodium;Cytoskeleton	Aortic aneurysm, familial thoracic 7	Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. Apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis.	Can probably be down-regulated by phosphorylation. Tyrosine phosphorylation by ABL1 increases kinase activity, reverses MLCK-mediated inhibition of Arp2/3-mediated actin polymerization, and enhances CTTN-binding. Phosphorylation by SRC at Tyr-464 and Tyr-471 promotes CTTN binding.;Acetylated at Lys-608 by NAA10/ARD1 via a calcium-dependent signaling; this acetylation represses kinase activity and reduces tumor cell migration.;The C-terminus is deglutamylated by AGTPBP1/CCP1, AGBL1/CCP4 and AGBL4/CCP6, leading to the formation of Myosin light chain kinase, smooth muscle, deglutamylated form. The consequences of C-terminal deglutamylation are unknown (By similarity).;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MYLK is phosphorylated by SRC (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	Calcium signaling pathway;Vascular smooth muscle contraction;Focal adhesion;Regulation of actin cytoskeleton;Gastric acid secretion;Smooth Muscle Contraction;RHO GTPases activate PAKs	PE1	3
+NX_Q15750	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	504	54644	5.31	0	Cytosol;Nucleus speckle	NA	May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.	Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.	NA	MAPK signaling pathway;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;Leishmaniasis;Toxoplasmosis;Herpes simplex infection;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;IRAK2 mediated activation of TAK1 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling	PE1	22
+NX_Q15751	Probable E3 ubiquitin-protein ligase HERC1	4861	532228	5.69	0	Membrane;Golgi apparatus;Cytosol	Macrocephaly, dysmorphic facies, and psychomotor retardation	Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	NA	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	15
+NX_Q15758	Neutral amino acid transporter B(0)	541	56598	5.34	8	Melanosome;Cell membrane	NA	(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.;Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).;(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.;(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.	NA	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.	Protein digestion and absorption;Amino acid transport across the plasma membrane	PE1	19
+NX_Q15759	Mitogen-activated protein kinase 11	364	41357	5.56	0	Cytoplasm;Mitochondrion;Nucleus	NA	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment.	Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6, which activates the enzyme.;Autophosphorylated	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK signaling pathway;VEGF signaling pathway;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Dopaminergic synapse;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Amyotrophic lateral sclerosis (ALS);Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Salmonella infection;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Hepatitis C;Influenza A;DSCAM interactions;NOD1/2 Signaling Pathway;Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;VEGFA-VEGFR2 Pathway;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;KSRP (KHSRP) binds and destabilizes mRNA;p38MAPK events;RHO GTPases Activate NADPH Oxidases;ERK/MAPK targets;Activation of the AP-1 family of transcription factors;Regulation of TP53 Activity through Phosphorylation;Myogenesis	PE1	22
+NX_Q15760	Probable G-protein coupled receptor 19	415	47687	9.6	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	12
+NX_Q15761	Neuropeptide Y receptor type 5	445	50727	9	7	Cell membrane	NA	Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors	PE2	4
+NX_Q15762	CD226 antigen	336	38614	8.11	1	Midbody;Cell membrane	NA	Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).	NA	NA	Cell adhesion molecules (CAMs);Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	18
+NX_Q15768	Ephrin-B3	340	35835	8.85	1	Membrane	NA	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).;(Microbial infection) Acts as a receptor for nipah virus and hendra virus.	NA	Belongs to the ephrin family.	Axon guidance;EPH-Ephrin signaling;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells	PE1	17
+NX_Q15771	Ras-related protein Rab-30	203	23058	4.91	0	trans-Golgi network;Cytoplasm;Golgi apparatus;Membrane;Cytoplasmic vesicle	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.	NA	Belongs to the small GTPase superfamily. Rab family.	Intra-Golgi traffic;RAB geranylgeranylation	PE1	11
+NX_Q15772	Striated muscle preferentially expressed protein kinase	3267	354289	8.82	0	Cytoplasmic vesicle;Nucleus	Myopathy, centronuclear, 5	May have a role in regulating the growth and differentiation of arterial smooth muscle cells.	May be autophosphorylated.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	2
+NX_Q15773	Myeloid leukemia factor 2	248	28147	6.4	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	Belongs to the MLF family.	NA	PE1	12
+NX_Q15776	Zinc finger protein with KRAB and SCAN domains 8	578	65816	7.04	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	6
+NX_Q15777	Metallophosphoesterase MPPED2	294	33360	5.85	0	Cytoplasmic vesicle;Mitochondrion;Nucleolus	NA	Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.	NA	Belongs to the UPF0046 family.	NA	PE1	11
+NX_Q15782	Chitinase-3-like protein 2	390	43501	7.11	0	Secreted	NA	Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.	NA	Belongs to the glycosyl hydrolase 18 family.	NA	PE1	1
+NX_Q15784	Neurogenic differentiation factor 2	382	41361	6.29	0	Nucleus	Epileptic encephalopathy, early infantile, 72	Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity).	NA	NA	NA	PE1	17
+NX_Q15785	Mitochondrial import receptor subunit TOM34	309	34559	9.12	0	Mitochondrion outer membrane;Cytoplasm	NA	Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.	NA	Belongs to the Tom34 family.	NA	PE1	20
+NX_Q15788	Nuclear receptor coactivator 1	1441	156757	5.84	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.;Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response.	Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.;Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.	Belongs to the SRC/p160 nuclear receptor coactivator family.	HATs acetylate histones;PPARA activates gene expression;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Endogenous sterols;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Recycling of bile acids and salts;Synthesis of bile acids and bile salts;Estrogen-dependent gene expression;SUMOylation of transcription cofactors	PE1	2
+NX_Q15796	Mothers against decapentaplegic homolog 2	467	52306	6.13	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.	Acetylation increases DNA binding activity in vitro and enhances its association with target promoters in vivo. Acetylation in the nucleus by EP300 is enhanced by TGF-beta.;Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases. TGF-beta-induced Ser-465/467 phosphorylation declines progressively in a KMT5A-dependent manner. Able to interact with SMURF2 when phosphorylated on Ser-465/467, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1.;Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity.;In response to TGF-beta, ubiquitinated by NEDD4L; which promotes its degradation. Monoubiquitinated, leading to prevent DNA-binding (By similarity). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (PubMed:21947082). Ubiquitinated by RNF111, leading to its degradation: only SMAD2 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD2 and regulating its turnover (By similarity).;SMAD2 is phosphorylated by ACVR1C;SMAD2 is phosphorylated by ACVR1B (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the dwarfin/SMAD family.	Cell cycle;Endocytosis;Wnt signaling pathway;TGF-beta signaling pathway;Adherens junction;Chagas disease (American trypanosomiasis);HTLV-I infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Transcriptional regulation of pluripotent stem cells;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;Signaling by NODAL;Signaling by Activin;SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD4 MH2 Domain Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;Ub-specific processing proteases;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell cycle genes	PE1	18
+NX_Q15797	Mothers against decapentaplegic homolog 1	465	52260	6.9	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.	Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4.;Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (By similarity).	Belongs to the dwarfin/SMAD family.	TGF-beta signaling pathway;Signaling by BMP;Ub-specific processing proteases;RUNX2 regulates bone development	PE1	4
+NX_Q15800	Methylsterol monooxygenase 1	293	35216	6.75	3	Endoplasmic reticulum membrane	Microcephaly, congenital cataract, and psoriasiform dermatitis	Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol.	NA	Belongs to the sterol desaturase family.	Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6.;Steroid biosynthesis;Metabolic pathways;Cholesterol biosynthesis	PE1	4
+NX_Q15811	Intersectin-1	1721	195422	7.76	0	Cytoplasm;Cell membrane;Synaptosome;Recycling endosome;Endomembrane system;Clathrin-coated pit;Endosome;Lamellipodium;Nucleus envelope;Cytoplasmic vesicle	NA	Plays a role in synaptic vesicle endocytosis in brain neurons.;Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688).	NA	NA	EPHB-mediated forward signaling;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	21
+NX_Q15813	Tubulin-specific chaperone E	527	59346	6.32	0	Cytoplasm;Cytoskeleton	Hypoparathyroidism-retardation-dysmorphism syndrome;Kenny-Caffey syndrome 1;Encephalopathy, progressive, with amyotrophy and optic atrophy	Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.	NA	Belongs to the TBCE family.	Post-chaperonin tubulin folding pathway	PE1	1
+NX_Q15814	Tubulin-specific chaperone C	346	39248	5.55	0	Cytoplasm;Cytosol	NA	Tubulin-folding protein; involved in the final step of the tubulin folding pathway.	NA	Belongs to the TBCC family.	Post-chaperonin tubulin folding pathway	PE1	6
+NX_Q15818	Neuronal pentraxin-1	432	47122	6.16	0	Secretory vesicle	NA	May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.	NA	NA	NA	PE1	17
+NX_Q15819	Ubiquitin-conjugating enzyme E2 variant 2	145	16363	7.79	0	Cytoplasm;Nucleus	NA	Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.	NA	Belongs to the ubiquitin-conjugating enzyme family.	Antigen processing: Ubiquitination &amp; Proteasome degradation;G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Formation of Incision Complex in GG-NER;E3 ubiquitin ligases ubiquitinate target proteins	PE1	8
+NX_Q15822	Neuronal acetylcholine receptor subunit alpha-2	529	59765	5.69	4	Postsynaptic cell membrane;Cell membrane	Epilepsy, nocturnal frontal lobe, 4;Seizures, benign familial infantile, 6	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily.	Neuroactive ligand-receptor interaction;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly calcium permeable nicotinic acetylcholine receptors	PE1	8
+NX_Q15825	Neuronal acetylcholine receptor subunit alpha-6	494	56898	6.16	4	Postsynaptic cell membrane;Cell membrane	NA	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-6/CHRNA6 sub-subfamily.	Neuroactive ligand-receptor interaction;Cholinergic synapse;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Highly calcium permeable nicotinic acetylcholine receptors	PE1	8
+NX_Q15828	Cystatin-M	149	16511	8.32	0	Cytosol;Secreted;Cell membrane	NA	Shows moderate inhibition of cathepsin B but is not active against cathepsin C.	Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor.	Belongs to the cystatin family.	NA	PE1	11
+NX_Q15831	Serine/threonine-protein kinase STK11	433	48636	7.12	0	Cytoplasm;Mitochondrion;Membrane;Nucleoplasm;Cytosol;Nucleus	Testicular germ cell tumor;Peutz-Jeghers syndrome	Has a role in spermiogenesis.;Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).	Phosphorylated by ATM at Thr-363 following ionizing radiation (IR). Phosphorylation at Ser-428 by RPS6KA1 and/or some PKA is required to inhibit cell growth. Phosphorylation at Ser-428 is also required during neuronal polarization to mediate phosphorylation of BRSK1 and BRSK2 (By similarity). Phosphorylation by PKC/PRKCZ at Ser-428 promotes peroxynitrite-induced nuclear export of STK11, leading to PTEN activation and subsequent inhibition of AKT signaling. Phosphorylation by PKC/PRKCZ at Ser-399 in isoform 2 promotes metformin (or peroxynitrite)-induced nuclear export of STK11 and activation of AMPK. UV radiation-induced phosphorylation at Thr-363 mediates CDKN1A degradation (By similarity).;Acetylated. Deacetylation at Lys-48 enhances cytoplasmic localization and kinase activity in vitro.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.	mTOR signaling pathway;Adipocytokine signaling pathway;Energy dependent regulation of mTOR by LKB1-AMPK;AMPK inhibits chREBP transcriptional activation activity;Regulation of TP53 Activity through Phosphorylation;FOXO-mediated transcription of cell death genes	PE1	19
+NX_Q15833	Syntaxin-binding protein 2	593	66453	6.11	0	Cytosol	Familial hemophagocytic lymphohistiocytosis 5	Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.	NA	Belongs to the STXBP/unc-18/SEC1 family.	Platelet degranulation;Other interleukin signaling	PE1	19
+NX_Q15834	Coiled-coil domain-containing protein 85B	202	22091	5.06	0	Adherens junction;Centrosome;Nucleus	NA	(Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication.;Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity).	NA	Belongs to the CCDC85 family.	NA	PE1	11
+NX_Q15835	Rhodopsin kinase GRK1	563	63526	5.63	0	Membrane;Photoreceptor outer segment	Night blindness, congenital stationary, Oguchi type 2	Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).	Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP.;Farnesylation is required for full activity.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Chemokine signaling pathway;Endocytosis;Phototransduction;Inactivation, recovery and regulation of the phototransduction cascade	PE1	13
+NX_Q15836	Vesicle-associated membrane protein 3	100	11309	8.89	1	Membrane;Synaptosome	NA	SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.	(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln-|-Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120).;(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln-|-Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120).;(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys-|-Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.	Belongs to the synaptobrevin family.	SNARE interactions in vesicular transport;Phagosome;ER-Phagosome pathway;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	1
+NX_Q15842	ATP-sensitive inward rectifier potassium channel 8	424	47968	9.38	2	Membrane	Hypertrichotic osteochondrodysplasia;Sudden infant death syndrome	This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity).	NA	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ8 subfamily.	ATP sensitive Potassium channels	PE1	12
+NX_Q15843	NEDD8	81	9072	7.99	0	Nucleoplasm;Cytosol;Nucleus	NA	Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.	Cleavage of precursor form by UCHL3 or SENP8 is necessary for function.	Belongs to the ubiquitin family.	Iron uptake and transport;TGF-beta receptor signaling activates SMADs;UCH proteinases;Cargo recognition for clathrin-mediated endocytosis;Neddylation	PE1	14
+NX_Q15846	Clusterin-like protein 1	466	54215	5.09	0	Endoplasmic reticulum;Secreted;Cell membrane	NA	NA	NA	Belongs to the clusterin family.	NA	PE1	18
+NX_Q15847	Adipogenesis regulatory factor	76	7855	5.17	0	Nucleoplasm;Cytosol;Nucleus	NA	Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin.	NA	NA	Transcriptional regulation of white adipocyte differentiation	PE1	10
+NX_Q15848	Adiponectin	244	26414	5.42	0	Secreted	Adiponectin deficiency;Diabetes mellitus, non-insulin-dependent	Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.	O-glycosylated. Not N-glycosylated. O-linked glycans on hydroxylysines consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. Sialylated to varying degrees depending on tissue. Thr-22 appears to be the major site of sialylation. Higher sialylation found in SGBS adipocytes than in HEK fibroblasts. Sialylation is not required neither for heterodimerization nor for secretion. Not sialylated on the glycosylated hydroxylysines. Desialylated forms are rapidly cleared from the circulation.;HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagen-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes.;Succination of Cys-36 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits polymerization and secretion of adiponectin. Adiponectin is a major target for succination in both adipocytes and adipose tissue of diabetic mammals. It was proposed that succination of proteins is a biomarker of mitochondrial stress and accumulation of Krebs cycle intermediates in adipose tissue in diabetes and that succination of adiponectin may contribute to the decrease in plasma adiponectin in diabetes.	NA	PPAR signaling pathway;Adipocytokine signaling pathway;Type II diabetes mellitus;Transcriptional regulation of white adipocyte differentiation;AMPK inhibits chREBP transcriptional activation activity	PE1	3
+NX_Q15849	Urea transporter 2	920	101209	6.51	17	Apical cell membrane	NA	Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.	NA	Belongs to the urea transporter family.	Transport of bile salts and organic acids, metal ions and amine compounds	PE1	18
+NX_Q15853	Upstream stimulatory factor 2	346	36955	4.97	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.	NA	NA	Estrogen-dependent gene expression	PE1	19
+NX_Q15858	Sodium channel protein type 9 subunit alpha	1988	226372	6.55	24	Neuron projection;Focal adhesion;Cytoskeleton;Cell membrane	Primary erythermalgia;Febrile seizures, familial, 3B;Paroxysmal extreme pain disorder;Generalized epilepsy with febrile seizures plus 7;Indifference to pain, congenital, autosomal recessive	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).	Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.;Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents.	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	2
+NX_Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	2313	261731	8.52	24	Membrane;Cytosol;Cytoskeleton;Cell membrane	Epileptic encephalopathy, early infantile, 69	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.	NA	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily.	MAPK signaling pathway;Calcium signaling pathway;Type II diabetes mellitus;Presynaptic depolarization and calcium channel opening;Regulation of insulin secretion	PE1	1
+NX_Q15884	Protein FAM189A2	450	49703	6.57	1	Membrane	NA	NA	NA	Belongs to the FAM189 family.	NA	PE1	9
+NX_Q15904	V-type proton ATPase subunit S1	470	52026	5.73	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane;Cell membrane;Endoplasmic reticulum;Cytosol;Cytoskeleton	Immunodeficiency 47	Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).	N-glycosylated.	Belongs to the vacuolar ATPase subunit S1 family.	Oxidative phosphorylation;Metabolic pathways;Lysosome;Phagosome;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Tuberculosis;Rheumatoid arthritis;Transferrin endocytosis and recycling;Insulin receptor recycling;Ion channel transport	PE1	X
+NX_Q15906	Vacuolar protein sorting-associated protein 72 homolog	364	40594	6.09	0	Nucleus speckle;Nucleus	NA	Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AFZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.	NA	Belongs to the VPS72/YL1 family.	HATs acetylate histones	PE1	1
+NX_Q15907	Ras-related protein Rab-11B	218	24489	5.64	0	Phagosome membrane;Centriolar satellite;Synaptic vesicle membrane;Recycling endosome membrane;Cytoplasmic vesicle	Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.	Citrullinated by PADI4.	Belongs to the small GTPase superfamily. Rab family.	Endocytosis;Vasopressin-regulated water reabsorption;TBC/RABGAPs;RAB geranylgeranylation	PE1	19
+NX_Q15910	Histone-lysine N-methyltransferase EZH2	746	85363	6.65	0	Nucleoplasm;Nucleus	Weaver syndrome	Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.	Glycosylated: O-GlcNAcylation at Ser-75 by OGT increases stability of EZH2 and facilitates the formation of H3K27me3 by the PRC2/EED-EZH2 complex.;Phosphorylated by AKT1. Phosphorylation by AKT1 reduces methyltransferase activity. Phosphorylation at Thr-345 by CDK1 and CDK2 promotes maintenance of H3K27me3 levels at EZH2-target loci, thus leading to epigenetic gene silencing.;Sumoylated.	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.	PKMTs methylate histone lysines;Oxidative Stress Induced Senescence;PRC2 methylates histones and DNA;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Transcriptional Regulation by E2F6;Regulation of PTEN gene transcription	PE1	7
+NX_Q15911	Zinc finger homeobox protein 3	3703	404419	5.82	0	Cytoplasm;Nucleus	NA	Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010).	Ubiquitinated, leading to its proteasomal degradation.;Adult brain-derived ZFHX3 is sensitive, but embryonic brain-derived ZFHX3 is resistant to calpain 1-mediated proteolysis.;Nuclear localization is essential for its sumoylation.;Phosphorylation decreases its sensitivity to calpain-mediated proteolysis.	NA	RUNX3 regulates CDKN1A transcription	PE1	16
+NX_Q15915	Zinc finger protein ZIC 1	447	48309	8.7	0	Cytoplasm;Nucleoplasm;Nucleus	Craniosynostosis 6	Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).	NA	Belongs to the GLI C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q15916	Zinc finger and BTB domain-containing protein 6	424	48236	6.29	0	Nucleoplasm;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	9
+NX_Q15928	Zinc finger protein 141	474	55249	9.43	0	Nucleus	Polydactyly, postaxial A6	May be involved in transcriptional regulation as a repressor. Plays a role in limb development.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	4
+NX_Q15929	Putative zinc finger protein 56	161	18651	8.85	0	Nucleus	NA	NA	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE5	19
+NX_Q15935	Zinc finger protein 77	545	61964	9.04	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q15937	Zinc finger protein 79	498	55350	8.54	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	9
+NX_Q15940	Putative zinc finger protein 726P1	193	22988	9.85	0	NA	NA	NA	NA	NA	Generic Transcription Pathway	PE5	19
+NX_Q15942	Zyxin	572	61277	6.22	0	Cytoplasm;Focal adhesion;Nucleus;Cytoskeleton	NA	Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).	ZYX is phosphorylated by MAPK3	Belongs to the zyxin/ajuba family.	Focal adhesion	PE1	7
+NX_Q15973	Zinc finger protein 124	351	40217	9.11	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q16048	Putative pro-MCH-like protein 1	86	9715	6.72	0	NA	NA	NA	NA	Belongs to the melanin-concentrating hormone family.	NA	PE5	5
+NX_Q16082	Heat shock protein beta-2	182	20233	5.07	0	Cytoplasm;Nucleus	NA	May regulate the kinase DMPK.	NA	Belongs to the small heat shock protein (HSP20) family.	NA	PE1	11
+NX_Q16099	Glutamate receptor ionotropic, kainate 4	956	107246	6.3	3	Cell membrane;Postsynaptic cell membrane	NA	Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.	NA	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;Activation of Ca-permeable Kainate Receptor	PE2	11
+NX_Q16134	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial	617	68495	7.31	0	Mitochondrion inner membrane	Glutaric aciduria 2C	Accepts electrons from ETF and reduces ubiquinone.	NA	Belongs to the ETF-QO/FixC family.	Respiratory electron transport	PE1	4
+NX_Q16143	Beta-synuclein	134	14288	4.41	0	Cytoplasm	NA	Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.	Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.	Belongs to the synuclein family.	MTF1 activates gene expression	PE1	5
+NX_Q16181	Septin-7	437	50680	8.76	0	Cytoplasm;Cleavage furrow;Nucleolus;Midbody;Cilium axoneme;Flagellum;Cytosol;Spindle;Kinetochore;Cytoskeleton	NA	Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	MAPK6/MAPK4 signaling	PE1	7
+NX_Q16186	Proteasomal ubiquitin receptor ADRM1	407	42153	4.96	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.	NA	Belongs to the ADRM1 family.	UCH proteinases;Ub-specific processing proteases	PE1	20
+NX_Q16204	Coiled-coil domain-containing protein 6	474	53291	6.87	0	Cytoplasm;Cytosol;Cytoskeleton	NA	NA	NA	NA	Pathways in cancer;Thyroid cancer	PE1	10
+NX_Q16206	Ecto-NOX disulfide-thiol exchanger 2	610	70082	5.67	0	Extracellular space;Cell membrane	NA	May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.	Glycosylated.	Belongs to the ENOX family.	NA	PE1	X
+NX_Q16222	UDP-N-acetylhexosamine pyrophosphorylase	522	58769	5.92	0	Cytoplasm;Nucleoplasm;Cytosol;Cell membrane	NA	Has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.;Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc.	NA	Belongs to the UDPGP type 1 family.	Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Synthesis of UDP-N-acetyl-glucosamine	PE1	1
+NX_Q16236	Nuclear factor erythroid 2-related factor 2	605	67827	4.67	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	Immunodeficiency, developmental delay, and hypohomocysteinemia	Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919).	Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.;Glycation impairs transcription factor activity by preventing heterodimerization with small Maf proteins (PubMed:31398338). Deglycation by FN3K restores activity (PubMed:31398338).;Acetylation at Lys-596 and Lys-599 increases nuclear localization whereas deacetylation by SIRT1 enhances cytoplasmic presence.;Ubiquitinated in the cytoplasm by the BCR(KEAP1) E3 ubiquitin ligase complex leading to its degradation (PubMed:15601839, PubMed:15983046, PubMed:19489739). In response to oxidative stress, electrophile metabolites, such as sulforaphane, modify KEAP1, leading to inhibit activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and activity (PubMed:19489739, PubMed:29590092). In response to autophagy, the BCR(KEAP1) complex is inactivated (By similarity).	Belongs to the bZIP family. CNC subfamily.	Protein processing in endoplasmic reticulum	PE1	2
+NX_Q16254	Transcription factor E2F4	413	43960	4.66	0	Nucleoplasm;Nucleus	NA	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.	Differentially phosphorylated in vivo.	Belongs to the E2F/DP family.	Cell cycle;TGF-beta signaling pathway;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;G0 and Early G1;G1/S-Specific Transcription;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry;Cyclin D associated events in G1;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	PE1	16
+NX_Q16270	Insulin-like growth factor-binding protein 7	282	29130	8.25	0	Golgi apparatus;Secreted	Retinal arterial macroaneurysm with supravalvular pulmonic stenosis	Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.	N-glycosylated.	NA	Senescence-Associated Secretory Phenotype (SASP);Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	4
+NX_Q16280	Cyclic nucleotide-gated olfactory channel	664	76048	5.88	6	Membrane	NA	Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.	NA	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.	VxPx cargo-targeting to cilium	PE2	X
+NX_Q16281	Cyclic nucleotide-gated cation channel alpha-3	694	78838	7.56	6	Membrane	Achromatopsia 2	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.	NA	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily.	Olfactory transduction	PE1	2
+NX_Q16288	NT-3 growth factor receptor	839	94428	6.12	1	Membrane;Nucleus membrane;Nucleolus	NA	Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.	Ligand-mediated auto-phosphorylation.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	Neurotrophin signaling pathway;Receptor-type tyrosine-protein phosphatases;NTRK3 as a dependence receptor;Activated NTRK3 signals through RAS;Activated NTRK3 signals through PI3K;Signaling by NTRK3 (TRKC);NTF3 activates NTRK3 signaling;Activated NTRK3 signals through PLCG1	PE1	15
+NX_Q16322	Potassium voltage-gated channel subfamily A member 10	511	57785	4.85	6	Membrane;Nucleoplasm;Cytosol	NA	Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.	NA	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily.	Voltage gated Potassium channels	PE1	1
+NX_Q16342	Programmed cell death protein 2	344	38592	5.25	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.	Ubiquitinated by PRKN, promoting proteasomal degradation.	NA	NA	PE1	6
+NX_Q16348	Solute carrier family 15 member 2	729	81783	8.4	12	Cell membrane	NA	Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity).	NA	Belongs to the PTR2/POT transporter (TC 2.A.17) family.	Proton/oligopeptide cotransporters	PE1	3
+NX_Q16352	Alpha-internexin	499	55391	5.34	0	Cytoskeleton	NA	Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.	O-glycosylated.	Belongs to the intermediate filament family.	NA	PE1	10
+NX_Q16363	Laminin subunit alpha-4	1823	202524	5.89	0	Basement membrane;Cytosol;Cell membrane	Cardiomyopathy, dilated 1JJ	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	NA	NA	Focal adhesion;ECM-receptor interaction;African trypanosomiasis;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer;ECM proteoglycans;Non-integrin membrane-ECM interactions;Laminin interactions;MET activates PTK2 signaling	PE1	6
+NX_Q16378	Proline-rich protein 4	134	15097	6.5	0	Secreted	NA	NA	NA	NA	NA	PE1	12
+NX_Q16384	Protein SSX1	188	21931	9.46	0	NA	NA	Could act as a modulator of transcription.	NA	Belongs to the SSX family.	NA	PE1	X
+NX_Q16385	Protein SSX2	188	21620	5.61	0	Nucleus	NA	Could act as a modulator of transcription.	NA	Belongs to the SSX family.	NA	PE1	X
+NX_Q16394	Exostosin-1	746	86255	9.16	1	Endoplasmic reticulum membrane;Golgi apparatus membrane	Tricho-rhino-phalangeal syndrome 2;Hereditary multiple exostoses 1;Chondrosarcoma	Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).	NA	Belongs to the glycosyltransferase 47 family.	Protein modification; protein glycosylation.;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;HS-GAG biosynthesis;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS	PE1	8
+NX_Q16401	26S proteasome non-ATPase regulatory subunit 5	504	56196	5.35	0	Nucleoplasm;Cytosol	NA	Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.	NA	Belongs to the proteasome subunit S5B/HSM3 family.	Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	9
+NX_Q16445	Gamma-aminobutyric acid receptor subunit alpha-6	453	51024	8.39	4	Cell membrane;Postsynaptic cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;GABA receptor activation	PE1	5
+NX_Q16473	Putative tenascin-XA	311	33740	5.29	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_Q16478	Glutamate receptor ionotropic, kainate 5	980	109265	8.54	3	Postsynaptic cell membrane;Nucleoplasm;Cell membrane	NA	Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.	NA	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;Activation of Ca-permeable Kainate Receptor	PE1	19
+NX_Q16512	Serine/threonine-protein kinase N1	942	103932	5.99	0	Cytoplasm;Cleavage furrow;Cell membrane;Nucleoplasm;Midbody;Endosome;Cytosol;Nucleus	NA	PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.	Autophosphorylated; preferably on serine. Phosphorylated during mitosis.;(Microbial infection) In case of infection, polyubiquitinated by the bacterial E3 ubiquitin-protein ligase SspH1, leading to its proteasomal degradation.;Activated by limited proteolysis with trypsin.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Salmonella infection;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RHO GTPases activate PKNs	PE1	19
+NX_Q16513	Serine/threonine-protein kinase N2	984	112035	5.95	0	Cytoplasm;Cleavage furrow;Cell membrane;Cell junction;Membrane;Nucleoplasm;Midbody;Lamellipodium;Centrosome;Cytosol;Nucleus;Cytoskeleton	NA	(Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.;PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747).	Activated by limited proteolysis with trypsin (By similarity). Proteolytically cleaved by caspase-3 during the induction of apoptotic cell death.;Autophosphorylated. Phosphorylated during mitosis. Phosphorylated by CDK10 (PubMed:27104747).	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Salmonella infection;RHO GTPases activate PKNs	PE1	1
+NX_Q16514	Transcription initiation factor TFIID subunit 12	161	17924	7.78	0	Nucleus	NA	TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.	NA	Belongs to the TAF12 family.	Basal transcription factors;HATs acetylate histones;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation	PE1	1
+NX_Q16515	Acid-sensing ion channel 2	512	57709	5.07	2	Cell membrane	NA	Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.	NA	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily.	Taste transduction;Stimuli-sensing channels	PE1	17
+NX_Q16517	Neuronatin	81	9237	10.17	0	NA	NA	May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.	NA	Belongs to the neuronatin family.	NA	PE2	20
+NX_Q16518	Retinoid isomerohydrolase	533	60948	6.05	0	Microsome membrane;Cytoplasm;Cell membrane	Leber congenital amaurosis 2;Retinitis pigmentosa 20	Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).	Palmitoylation by LRAT regulates ligand binding specificity; the palmitoylated form (membrane form) specifically binds all-trans-retinyl-palmitate, while the soluble unpalmitoylated form binds all-trans-retinol (vitamin A) (By similarity).	Belongs to the carotenoid oxygenase family.	Retinol metabolism;The canonical retinoid cycle in rods (twilight vision)	PE1	1
+NX_Q16520	Basic leucine zipper transcriptional factor ATF-like	125	14120	8.82	0	Nucleoplasm;Cytoplasm;Nucleus	NA	AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).	Phosphorylated.;Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription (By similarity).	Belongs to the bZIP family.	Interleukin-4 and Interleukin-13 signaling	PE1	14
+NX_Q16526	Cryptochrome-1	586	66395	8.27	0	Cytoplasm;Nucleus membrane;Nucleoplasm;Nucleus;Cytoskeleton	Delayed sleep phase syndrome	Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-ARNTL/BMAL1 independently of PER proteins and is found at CLOCK-ARNTL/BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-ARNTL/BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Inhibits hepatic gluconeogenesis by decreasing nuclear FOXO1 levels that downregulates gluconeogenic gene expression (By similarity). Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4 (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Plays an essential role in the generation of circadian rhythms in the retina (By similarity). Represses the transcriptional activity of NR1I2 (By similarity).	Undergoes autophagy-mediated degradation in the liver in a time-dependent manner. Autophagic degradation of CRY1 (an inhibitor of gluconeogenesis) occurs during periods of reduced feeding allowing induction of gluconeogenesis and maintenance of blood glucose levels.;Phosphorylation on Ser-247 by MAPK is important for the inhibition of CLOCK-ARNTL/BMAL1-mediated transcriptional activity. Phosphorylation by CSNK1E requires interaction with PER1 or PER2. Phosphorylation at Ser-71 and Ser-280 by AMPK decreases protein stability. Phosphorylation at Ser-568 exhibits a robust circadian rhythm with a peak at CT8, increases protein stability, prevents SCF(FBXL3)-mediated degradation and is antagonized by interaction with PRKDC.;Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complexes, regulating the balance between degradation and stabilization. The SCF(FBXL3) complex is mainly nuclear and mediates ubiquitination and subsequent degradation of CRY1. In contrast, cytoplasmic SCF(FBXL21) complex-mediated ubiquitination leads to stabilize CRY1 and counteract the activity of the SCF(FBXL3) complex. The SCF(FBXL3) and SCF(FBXL21) complexes probably mediate ubiquitination at different Lys residues. Ubiquitination at Lys-11 and Lys-107 are specifically ubiquitinated by the SCF(FBXL21) complex but not by the SCF(FBXL3) complex. Ubiquitination may be inhibited by PER2 (PubMed:17463251, PubMed:22798407, PubMed:27565346). Deubiquitinated by USP7 (By similarity).	Belongs to the DNA photolyase class-1 family.	Circadian rhythm - mammal;Circadian Clock	PE1	12
+NX_Q16527	Cysteine and glycine-rich protein 2	193	20954	8.95	0	Nucleus	NA	Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.	NA	NA	NA	PE1	12
+NX_Q16531	DNA damage-binding protein 1	1140	126968	5.14	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity).	Ubiquitinated by CUL4A. Subsequently degraded by ubiquitin-dependent proteolysis.;Phosphorylated by ABL1.;DDB1 is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	Belongs to the DDB1 family.	Protein modification; protein ubiquitination.;Nucleotide excision repair;Ubiquitin mediated proteolysis;Nucleotide excision repair;Ubiquitin mediated proteolysis;Recognition of DNA damage by PCNA-containing replication complex;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;DNA Damage Recognition in GG-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;Neddylation	PE1	11
+NX_Q16533	snRNA-activating protein complex subunit 1	368	42994	9.53	0	Nucleoplasm;Nucleus;Nucleolus	NA	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.	NA	NA	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA polymerase II transcribes snRNA genes	PE1	14
+NX_Q16534	Hepatic leukemia factor	295	33199	7.76	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the bZIP family. PAR subfamily.	NA	PE2	17
+NX_Q16537	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	467	54699	6.51	0	Cytoplasm;Cytosol	NA	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Phosphorylated on serine residues.	Belongs to the phosphatase 2A regulatory subunit B56 family.	mRNA surveillance pathway;Oocyte meiosis;Wnt signaling pathway;Dopaminergic synapse;Degradation of beta-catenin by the destruction complex;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Negative regulation of MAPK pathway;RAF activation;Disassembly of the destruction complex and recruitment of AXIN to the membrane;CTLA4 inhibitory signaling;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Platelet sensitization by LDL;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	14
+NX_Q16538	Probable G-protein coupled receptor 162	588	63930	8.83	7	Centriolar satellite;Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	12
+NX_Q16539	Mitogen-activated protein kinase 14	360	41293	5.48	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	NA	(Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minute and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573).;Activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2.;Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression.;May play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'.	Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and enhances kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC3.;Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway.;Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation can also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323 phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP16. PPM1D also mediates dephosphorylation and inactivation of MAPK14 (PubMed:21283629).;MAPK14 is phosphorylated by MAP2K7	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK signaling pathway;VEGF signaling pathway;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Dopaminergic synapse;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Amyotrophic lateral sclerosis (ALS);Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Salmonella infection;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Hepatitis C;Influenza A;DSCAM interactions;NOD1/2 Signaling Pathway;Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;VEGFA-VEGFR2 Pathway;ADP signalling through P2Y purinoceptor 1;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;KSRP (KHSRP) binds and destabilizes mRNA;p38MAPK events;Platelet sensitization by LDL;RHO GTPases Activate NADPH Oxidases;ERK/MAPK targets;Activation of the AP-1 family of transcription factors;Regulation of TP53 Activity through Phosphorylation;Neutrophil degranulation;Myogenesis	PE1	6
+NX_Q16540	39S ribosomal protein L23, mitochondrial	153	17781	9.69	0	Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the universal ribosomal protein uL23 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	11
+NX_Q16543	Hsp90 co-chaperone Cdc37	378	44468	5.17	0	Cytoplasm;Cytosol;Nucleus	NA	Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).	Constitutively sumoylated by UBE2I.	Belongs to the CDC37 family.	Signaling by ERBB2;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Constitutive Signaling by EGFRvIII;Downregulation of ERBB2 signaling	PE1	19
+NX_Q16548	Bcl-2-related protein A1	175	20132	5.32	0	Cytoplasm	NA	Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity).	NA	Belongs to the Bcl-2 family.	NA	PE1	15
+NX_Q16549	Proprotein convertase subtilisin/kexin type 7	785	86247	5.51	1	trans-Golgi network membrane	NA	Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.	N-glycosylated.;Cysteine residues in the cytoplasmic tail are probably palmitoylated.	Belongs to the peptidase S8 family.	NA	PE1	11
+NX_Q16552	Interleukin-17A	155	17504	8.82	0	Secreted	NA	Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).	Found both in glycosylated and nonglycosylated forms.	Belongs to the IL-17 family.	Cytokine-cytokine receptor interaction;Rheumatoid arthritis;Interleukin-17 signaling;Interleukin-4 and Interleukin-13 signaling	PE1	6
+NX_Q16553	Lymphocyte antigen 6E	131	13507	8.06	0	Cell membrane	NA	Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response.	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	8
+NX_Q16555	Dihydropyrimidinase-related protein 2	572	62294	5.95	0	Membrane;Cytosol;Cell membrane;Cytoskeleton	NA	Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.	Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.;3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.;DPYSL2 is phosphorylated by FES;DPYSL2 is phosphorylated by YES1 (Phosphotyrosine:PTM-0255)	Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.	Axon guidance;Recycling pathway of L1;CRMPs in Sema3A signaling	PE1	8
+NX_Q16557	Pregnancy-specific beta-1-glycoprotein 3	428	47945	8.74	0	Secreted	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall	PE1	19
+NX_Q16558	Calcium-activated potassium channel subunit beta-1	191	21797	9.12	2	Membrane	NA	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.	N-glycosylated.	Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.	Vascular smooth muscle contraction;Ca2+ activated K+ channels;cGMP effects	PE1	5
+NX_Q16559	T-cell acute lymphocytic leukemia protein 2	108	12291	10.48	0	Cytosol	NA	NA	TAL2 is phosphorylated by MAPK7 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	9
+NX_Q16560	U11/U12 small nuclear ribonucleoprotein 35 kDa protein	246	29450	9.86	0	Nucleus;Nucleolus	NA	NA	NA	NA	mRNA Splicing - Minor Pathway	PE1	12
+NX_Q16563	Synaptophysin-like protein 1	259	28565	8.69	4	Cytoplasmic vesicle membrane;Melanosome	NA	NA	NA	Belongs to the synaptophysin/synaptobrevin family.	NA	PE1	7
+NX_Q16566	Calcium/calmodulin-dependent protein kinase type IV	473	51926	5.6	0	Nucleus;Cytoplasm;Nucleoplasm;Nucleolus	NA	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.	Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.;Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	Calcium signaling pathway;Osteoclast differentiation;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Transcriptional activation of mitochondrial biogenesis;CaMK IV-mediated phosphorylation of CREB;Regulation of MECP2 expression and activity;Loss of phosphorylation of MECP2 at T308;Negative regulation of NMDA receptor-mediated neuronal transmission	PE1	5
+NX_Q16568	Cocaine- and amphetamine-regulated transcript protein	116	12829	8.55	0	Secreted	NA	Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.	NA	Belongs to the CART family.	NA	PE1	5
+NX_Q16570	Atypical chemokine receptor 1	336	35553	6.1	7	Membrane;Recycling endosome;Early endosome	NA	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.	NA	Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.	Malaria;Peptide ligand-binding receptors	PE1	1
+NX_Q16572	Vesicular acetylcholine transporter	532	56903	5.81	12	Membrane	Myasthenic syndrome, congenital, 21, presynaptic	Involved in acetylcholine transport into synaptic vesicles.	NA	Belongs to the major facilitator superfamily. Vesicular transporter family.	Synaptic vesicle cycle;Cholinergic synapse;Acetylcholine Neurotransmitter Release Cycle;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	10
+NX_Q16576	Histone-binding protein RBBP7	425	47820	4.89	0	Nucleus	NA	Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.	NA	Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.	PKMTs methylate histone lysines;RMTs methylate histone arginines;HATs acetylate histones;RNA Polymerase I Transcription Initiation;Oxidative Stress Induced Senescence;PRC2 methylates histones and DNA;HDACs deacetylate histones;Deposition of new CENPA-containing nucleosomes at the centromere;Activation of anterior HOX genes in hindbrain development during early embryogenesis;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;Neddylation;Transcriptional Regulation by E2F6;Regulation of PTEN gene transcription	PE1	X
+NX_Q16581	C3a anaphylatoxin chemotactic receptor	482	53864	6.2	7	Cell membrane	NA	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.	O-glycosylated.;Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Staphylococcus aureus infection;G alpha (i) signalling events;Peptide ligand-binding receptors;Regulation of Complement cascade;Neutrophil degranulation	PE1	12
+NX_Q16584	Mitogen-activated protein kinase kinase kinase 11	847	92688	8.4	0	Cytosol;Centriolar satellite;Centrosome	NA	Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.	Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	11
+NX_Q16585	Beta-sarcoglycan	318	34777	8.86	1	Cytosol;Sarcolemma;Cytoskeleton	Muscular dystrophy, limb-girdle, autosomal recessive 4	Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.	Disulfide bonds are present.	Belongs to the sarcoglycan beta/delta/gamma/zeta family.	Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Viral myocarditis	PE1	4
+NX_Q16586	Alpha-sarcoglycan	387	42875	5.5	1	Sarcolemma;Cytoskeleton	Muscular dystrophy, limb-girdle, autosomal recessive 3	Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.	NA	Belongs to the sarcoglycan alpha/epsilon family.	Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Viral myocarditis	PE1	17
+NX_Q16587	Zinc finger protein 74	644	72207	8.77	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	May play a role in RNA metabolism.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	22
+NX_Q16589	Cyclin-G2	344	38866	5.33	0	Cytoplasm;Nucleoplasm;Cytosol	NA	May play a role in growth regulation and in negative regulation of cell cycle progression.	NA	Belongs to the cyclin family. Cyclin G subfamily.	p53 signaling pathway;FOXO-mediated transcription of cell cycle genes	PE1	4
+NX_Q16594	Transcription initiation factor TFIID subunit 9	264	28974	8.77	0	Nucleus	NA	Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.	NA	Belongs to the TAF9 family.	Ribosome biogenesis in eukaryotes;Basal transcription factors;HATs acetylate histones;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA polymerase II transcribes snRNA genes;Regulation of TP53 Activity through Phosphorylation	PE1	5
+NX_Q16595	Frataxin, mitochondrial	210	23135	8.8	0	Cytosol;Mitochondrion	Friedreich ataxia	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.	Processed in two steps by mitochondrial processing peptidase (MPP). MPP first cleaves the precursor to intermediate form and subsequently converts the intermediate to yield frataxin mature form (frataxin(81-210)) which is the predominant form. The additional forms, frataxin(56-210) and frataxin(78-210), seem to be produced when the normal maturation process is impaired; their physiological relevance is unsure.;FXN is phosphorylated by PASK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the frataxin family.	Mitochondrial protein import;Mitochondrial iron-sulfur cluster biogenesis	PE1	9
+NX_Q16600	Zinc finger protein 239	458	51591	7.71	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	10
+NX_Q16602	Calcitonin gene-related peptide type 1 receptor	461	52929	6.27	7	Cell membrane	NA	Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.	NA	Belongs to the G-protein coupled receptor 2 family.	Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;G alpha (s) signalling events;Calcitonin-like ligand receptors	PE1	2
+NX_Q16609	Putative apolipoprotein(a)-like protein 2	132	14886	5.21	0	Secreted	NA	NA	NA	NA	NA	PE5	6
+NX_Q16610	Extracellular matrix protein 1	540	60674	6.25	0	Nucleoplasm;Cytosol;Extracellular matrix	Lipoid proteinosis	Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.	NA	NA	Platelet degranulation	PE1	1
+NX_Q16611	Bcl-2 homologous antagonist/killer	211	23409	5.66	1	Mitochondrion outer membrane	NA	Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.	NA	Belongs to the Bcl-2 family.	Protein processing in endoplasmic reticulum;Release of apoptotic factors from the mitochondria;Activation and oligomerization of BAK protein	PE1	6
+NX_Q16612	Neuronal regeneration-related protein	68	7909	9.16	0	Cytoplasm;Cytoplasmic vesicle	NA	May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.	Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.	NA	NA	PE1	5
+NX_Q16613	Serotonin N-acetyltransferase	207	23344	7.2	0	Cytoplasm;Cytosol	NA	Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.	CAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.	Belongs to the acetyltransferase family. AANAT subfamily.	Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.;Tryptophan metabolism;Metabolic pathways;Serotonin and melatonin biosynthesis	PE1	17
+NX_Q16617	Protein NKG7	165	17665	5.88	4	Cytoplasmic vesicle;Cytoplasmic granule membrane;Cell membrane	NA	NA	NA	Belongs to the PMP-22/EMP/MP20 family.	NA	PE1	19
+NX_Q16619	Cardiotrophin-1	201	21227	9.18	0	Secreted	NA	Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.	NA	Belongs to the IL-6 superfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;IL-6-type cytokine receptor ligand interactions	PE1	16
+NX_Q16620	BDNF/NT-3 growth factors receptor	822	91999	6.01	1	Cell membrane;Endosome membrane;Postsynaptic density;Early endosome membrane;Dendrite;Cytosol;Axon;Perinuclear region	Obesity, hyperphagia, and developmental delay;Epileptic encephalopathy, early infantile, 58	Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.	Is not phosphorylated.;Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).;Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	MAPK signaling pathway;Neurotrophin signaling pathway;NGF-independant TRKA activation;Activated NTRK2 signals through RAS;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through CDK5;NTRK2 activates RAC1;NTF4 activates NTRK2 (TRKB) signaling;Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through PI3K;Activated NTRK2 signals through FYN;BDNF activates NTRK2 (TRKB) signaling;NTF3 activates NTRK2 (TRKB) signaling	PE1	9
+NX_Q16621	Transcription factor NF-E2 45 kDa subunit	373	41473	4.89	0	Cytoplasm;Nucleoplasm;PML body;Cytoskeleton	NA	Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.	Sumoylated. Sumoylation is required for translocation to nuclear bodies PODs, anchoring to the gene loci, and transactivation of the beta-globin gene.;Ubiquitinated mainly by 'Lys63'-linked ubiquitin. Polyubiquitination with 'Lys63'-linked ubiquitin by ITCH retains NFE2 in the cytoplasm preventing its transactivation activity. In undifferentiated erythrocyte, ubiquitinated after MAPK8-mediatd phosphorylation leading to protein degradation (By similarity).;Phosphorylated on serine residues. In undifferentiated erythrocytes, phosphorylated by MAPK8 which then leads to ubiquitination and protein degradation.	Belongs to the bZIP family. CNC subfamily.	Factors involved in megakaryocyte development and platelet production;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	12
+NX_Q16623	Syntaxin-1A	288	33023	5.14	1	Secreted;Synaptic vesicle membrane;Cell membrane;Synaptosome	NA	Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Plays also an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity).	Phosphorylated by CK2 (By similarity). Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1.;Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis.	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;Synaptic vesicle cycle;Insulin processing;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation;LGI-ADAM interactions;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Regulation of insulin secretion;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Toxicity of botulinum toxin type C (BoNT/C);Neurexins and neuroligins;Other interleukin signaling;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	7
+NX_Q16625	Occludin	522	59144	5.77	4	Tight junction;Cell junction;Cell membrane	Pseudo-TORCH syndrome 1	May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.	Dephosphorylated by PTPRJ. The tyrosine phosphorylation on Tyr-398 and Tyr-402 reduces its ability to interact with TJP1. Phosphorylation at Ser-490 also attenuates the interaction with TJP1.;OCLN is phosphorylated by MAPK3;OCLN is phosphorylated by YES1	Belongs to the ELL/occludin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Pathogenic Escherichia coli infection;Hepatitis C;Apoptotic cleavage of cell adhesion proteins;RUNX1 regulates expression of components of tight junctions	PE1	5
+NX_Q16626	Male-enhanced antigen 1	185	19905	4.13	0	Nucleoplasm;Cytosol	NA	May play an important role in spermatogenesis and/or testis development.	NA	NA	NA	PE1	6
+NX_Q16627	C-C motif chemokine 14	93	10678	8.95	0	Secreted	NA	Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.	HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.;The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway	PE1	17
+NX_Q16629	Serine/arginine-rich splicing factor 7	238	27367	11.83	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.	Extensively phosphorylated on serine residues in the RS domain.;SRSF7 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the splicing factor SR family.	Spliceosome;Herpes simplex infection;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	2
+NX_Q16630	Cleavage and polyadenylation specificity factor subunit 6	551	59210	6.66	0	Cytoplasm;Nucleoplasm;Nucleus speckle;Nucleus	NA	Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460).	Phosphorylated (PubMed:29276085). Phosphorylated in the Arg/Ser-rich domain by SRPK1, in vitro (PubMed:29276085).;Symmetrically dimethylated on arginine residues in the GAR motif by PRMT5 in a WDR77- and CLNS1A-dependent manner (PubMed:20562214). Asymmetrically dimethylated on arginine residues in the GAR motif by PRMT1 (PubMed:20562214).	Belongs to the RRM CPSF6/7 family.	mRNA surveillance pathway;Signaling by FGFR1 in disease;Signaling by cytosolic FGFR1 fusion mutants	PE1	12
+NX_Q16633	POU domain class 2-associating factor 1	256	27436	4.87	0	Nucleus	NA	Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.	Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.	Belongs to the POU2AF1 family.	NA	PE1	11
+NX_Q16635	Tafazzin	292	33459	9.1	1	Membrane;Endoplasmic reticulum;Cytoplasm;Cell membrane	Barth syndrome	Some isoforms may be involved in cardiolipin (CL) metabolism.	NA	Belongs to the taffazin family.	Glycerophospholipid metabolism;Mitochondrial protein import;Acyl chain remodeling of CL	PE1	X
+NX_Q16637	Survival motor neuron protein	294	31849	6.13	0	Cajal body;Cytoplasm;Z line;Neuron projection;Gem;Perikaryon;Cytosol;Axon;Cytoplasmic granule;Nucleus	Spinal muscular atrophy 3;Spinal muscular atrophy 1;Spinal muscular atrophy 2;Spinal muscular atrophy 4	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).	NA	Belongs to the SMN family.	RNA transport;RNA transport;snRNP Assembly	PE1	5
+NX_Q16643	Drebrin	649	71429	4.41	0	Cytoplasm;Cell cortex;Cell membrane;Growth cone;Cell junction;Dendrite;Cytoskeleton	Alzheimer disease	Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity).	DBN1 is phosphorylated by ABL2 (Phosphotyrosine:PTM-0255)	NA	NA	PE1	5
+NX_Q16644	MAP kinase-activated protein kinase 3	382	42987	6.87	0	Nucleoplasm;Cytoplasm;Nucleus	Macular dystrophy, patterned, 3	Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.	Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1. Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-201, Ser-251 and Thr-313 (By similarity).;MAPKAPK3 is phosphorylated by MAPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAPKAPK3 is phosphorylated by MAPK12 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAPKAPK3 is phosphorylated by MAPK10 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAPKAPK3 is phosphorylated by MAPK9 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAPKAPK3 is phosphorylated by MAPK13 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAPKAPK3 is phosphorylated by MAPK14 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	MAPK signaling pathway;VEGF signaling pathway;Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;VEGFA-VEGFR2 Pathway;p38MAPK events	PE1	3
+NX_Q16647	Prostacyclin synthase	500	57104	6.8	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	Essential hypertension	Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).	NA	Belongs to the cytochrome P450 family.	Arachidonic acid metabolism;Metabolic pathways;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol;Nicotinamide salvaging;Eicosanoids;Sterols are 12-hydroxylated by CYP8B1	PE1	20
+NX_Q16649	Nuclear factor interleukin-3-regulated protein	462	51472	6.7	0	Nucleus	NA	Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity).	NA	Belongs to the bZIP family. NFIL3 subfamily.	Circadian Clock	PE1	9
+NX_Q16650	T-box brain protein 1	682	74053	6.89	0	Nucleus	Intellectual developmental disorder with autism and speech delay	Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:25232744, PubMed:30250039). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity).	NA	NA	NA	PE1	2
+NX_Q16651	Prostasin	343	36431	5.52	1	Cell membrane;Extracellular space	NA	Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).	NA	Belongs to the peptidase S1 family.	Formation of the cornified envelope	PE1	16
+NX_Q16653	Myelin-oligodendrocyte glycoprotein	247	28193	8.87	2	Cell membrane	Narcolepsy 7	Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.;(Microbial infection) Acts as a receptor for rubella virus.	NA	Belongs to the immunoglobulin superfamily. BTN/MOG family.	NA	PE1	6
+NX_Q16654	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	411	46469	6.19	0	Mitochondrion matrix	NA	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.	NA	Belongs to the PDK/BCKDK protein kinase family.	Signaling by Retinoic Acid;Regulation of pyruvate dehydrogenase (PDH) complex	PE1	7
+NX_Q16655	Melanoma antigen recognized by T-cells 1	118	13157	8.29	1	Golgi apparatus;trans-Golgi network membrane;Endoplasmic reticulum membrane;Melanosome	NA	Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.	Acylated.	NA	NA	PE1	9
+NX_Q16656	Nuclear respiratory factor 1	503	53541	4.94	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.	Phosphorylation enhances DNA binding.	Belongs to the NRF1/Ewg family.	Huntington's disease;PPARA activates gene expression;Transcriptional activation of mitochondrial biogenesis	PE1	7
+NX_Q16658	Fascin	493	54530	6.84	0	Cell cortex;Invadopodium;Cell membrane;Cell junction;Stress fiber;Filopodium;Cytosol;Microvillus;Cytoskeleton	NA	Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).	Phosphorylation at Ser-39 inhibits actin-binding (PubMed:8647875, PubMed:8999969). Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF (PubMed:22155786).	Belongs to the fascin family.	Interleukin-4 and Interleukin-13 signaling	PE1	7
+NX_Q16659	Mitogen-activated protein kinase 6	721	82681	4.91	0	Cytoplasm;Cytosol;Nucleus	NA	Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).	Ubiquitination at Met-1 leads to degradation by the proteasome pathway.;Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.;MAPK6 is phosphorylated by MAPKAPK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK6/MAPK4 signaling	PE1	15
+NX_Q16661	Guanylate cyclase activator 2B	112	12069	6.02	0	Secreted	NA	Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.	NA	Belongs to the guanylin family.	Digestion	PE1	1
+NX_Q16663	C-C motif chemokine 15	113	12248	8.49	0	Golgi apparatus;Secreted;Cytoplasmic vesicle	NA	Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway	PE1	17
+NX_Q16665	Hypoxia-inducible factor 1-alpha	826	92670	5.17	0	Cytoplasm;Nucleus speckle;Cell membrane;Nucleoplasm;Nucleus	NA	Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.	Polyubiquitinated; in normoxia, following hydroxylation and interaction with VHL. Lys-532 appears to be the principal site of ubiquitination. Clioquinol, the Cu/Zn-chelator, inhibits ubiquitination through preventing hydroxylation at Asn-803. Ubiquitinated by a CUL2-based E3 ligase.;Requires phosphorylation for DNA-binding. Phosphorylation at Ser-247 by CSNK1D/CK1 represses kinase activity and impairs ARNT binding. Phosphorylation by GSK3-beta and PLK3 promote degradation by the proteasome.;Sumoylated; with SUMO1 under hypoxia. Sumoylation is enhanced through interaction with RWDD3. Both sumoylation and desumoylation seem to be involved in the regulation of its stability during hypoxia. Sumoylation can promote either its stabilization or its VHL-dependent degradation by promoting hydroxyproline-independent HIF1A-VHL complex binding, thus leading to HIF1A ubiquitination and proteasomal degradation. Desumoylation by SENP1 increases its stability amd transcriptional activity. There is a disaccord between various publications on the effect of sumoylation and desumoylation on its stability and transcriptional activity.;Acetylation of Lys-532 by ARD1 increases interaction with VHL and stimulates subsequent proteasomal degradation (PubMed:12464182). Deacetylation of Lys-709 by SIRT2 increases its interaction with and hydroxylation by EGLN1 thereby inactivating HIF1A activity by inducing its proteasomal degradation (PubMed:24681946).;In normoxia, is hydroxylated on Pro-402 and Pro-564 in the oxygen-dependent degradation domain (ODD) by EGLN1/PHD2 and EGLN2/PHD1 (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). EGLN3/PHD3 has also been shown to hydroxylate Pro-564 (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). Deubiquitinated by USP20 (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization (PubMed:11292861, PubMed:11566883, PubMed:12351678, PubMed:15776016, PubMed:25974097). In normoxia, is hydroxylated on Asn-803 by HIF1AN, thus abrogating interaction with CREBBP and EP300 and preventing transcriptional activation (PubMed:12080085). This hydroxylation is inhibited by the Cu/Zn-chelator, Clioquinol (PubMed:12080085). Repressed by iron ion, via Fe(2+) prolyl hydroxylase (PHD) enzymes-mediated hydroxylation and subsequent proteasomal degradation (PubMed:28296633).;S-nitrosylation of Cys-800 may be responsible for increased recruitment of p300 coactivator necessary for transcriptional activity of HIF-1 complex.;The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains.	NA	mTOR signaling pathway;Pathways in cancer;Renal cell carcinoma;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Regulation of gene expression by Hypoxia-inducible Factor;Circadian Clock;NOTCH1 Intracellular Domain Regulates Transcription;PTK6 Expression;PTK6 promotes HIF1A stabilization;Ub-specific processing proteases;Interleukin-4 and Interleukin-13 signaling;Neddylation;Cellular response to hypoxia	PE1	14
+NX_Q16666	Gamma-interferon-inducible protein 16	785	88256	9.31	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.	Ubiquitinated by human herpes simplex virus 1 (HHV-1) ICP0 protein; leading to degradation by the proteasome.;Seems to show a minor degree of complex carbohydrate addition.;Phosphorylated on Ser and Thr.;Lysine acetylation in the multipartite nuclear localization signal (NLS) regulates the subcellular location. In vitro can be acetylated by p300/EP300 coupled to cytoplasmic localization.	Belongs to the HIN-200 family.	STING mediated induction of host immune responses;IRF3-mediated induction of type I IFN	PE1	1
+NX_Q16667	Cyclin-dependent kinase inhibitor 3	212	23805	5.97	0	Cytoplasm;Cytosol;Perinuclear region	Hepatocellular carcinoma	May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.	NA	Belongs to the protein-tyrosine phosphatase family.	NA	PE1	14
+NX_Q16670	Zinc finger and SCAN domain-containing protein 26	478	55254	8.36	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	6
+NX_Q16671	Anti-Muellerian hormone type-2 receptor	573	62750	5.53	1	Centriolar satellite;Membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	Persistent Muellerian duct syndrome 2	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	NA	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Signaling by BMP	PE1	12
+NX_Q16674	Melanoma-derived growth regulatory protein	131	14509	9.04	0	Secreted	NA	Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.	May possess two intramolecular disulfide bonds.	Belongs to the MIA/OTOR family.	NA	PE1	19
+NX_Q16676	Forkhead box protein D1	465	46140	5.03	0	Nucleus	NA	Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes (PubMed:27805902).	NA	NA	NA	PE1	5
+NX_Q16678	Cytochrome P450 1B1	543	60846	9.18	0	Microsome membrane;Endoplasmic reticulum membrane;Mitochondrion	Glaucoma 3, primary congenital, A;Anterior segment dysgenesis 6;Glaucoma 1, open angle, A	A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant hydroxylase activity toward E2 at the C-4 position (PubMed:11555828, PubMed:12865317). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (PubMed:10426814). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376, PubMed:15258110). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed:20972997). Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (PubMed:21068195). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (PubMed:10426814). Plays an important role in retinal vascular development. Under hyperoxic O2 conditions, promotes retinal angiogenesis and capillary morphogenesis, likely by metabolizing the oxygenated products generated during the oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression (By similarity).	NA	Belongs to the cytochrome P450 family.	Steroid hormone biosynthesis.;Cofactor metabolism; retinol metabolism.;Lipid metabolism; arachidonate metabolism.;Steroid hormone biosynthesis;Tryptophan metabolism;Metabolism of xenobiotics by cytochrome P450;Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET);Endogenous sterols;Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE);Defective CYP1B1 causes Glaucoma	PE1	2
+NX_Q16690	Dual specificity protein phosphatase 5	384	42047	8.69	0	Nucleus	NA	Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway;RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway	PE1	10
+NX_Q16695	Histone H3.1t	136	15508	11.13	0	Nucleoplasm;Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.;Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).;Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity).;Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).;Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.;Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation.;Ubiquitinated.;Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).;Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).;Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication (By similarity).	Belongs to the histone H3 family.	Systemic lupus erythematosus;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;Condensation of Prophase Chromosomes;DNA Damage/Telomere Stress Induced Senescence;Meiotic recombination;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ)	PE1	1
+NX_Q16696	Cytochrome P450 2A13	494	56688	9.31	0	Microsome membrane;Endoplasmic reticulum membrane	NA	Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.	NA	Belongs to the cytochrome P450 family.	Caffeine metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Xenobiotics;Aflatoxin activation and detoxification;Fatty acids;CYP2E1 reactions	PE1	19
+NX_Q16698	2,4-dienoyl-CoA reductase, mitochondrial	335	36068	9.35	0	Cytosol;Mitochondrion	2,4-dienoyl-CoA reductase deficiency	Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	PE1	8
+NX_Q16706	Alpha-mannosidase 2	1144	131141	7.24	1	Golgi apparatus;Golgi apparatus membrane	NA	Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.	Glycosylated.	Belongs to the glycosyl hydrolase 38 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Reactions specific to the complex N-glycan synthesis pathway;Intra-Golgi traffic	PE1	5
+NX_Q16718	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	116	13459	5.75	0	Mitochondrion inner membrane	NA	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFA5 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	7
+NX_Q16719	Kynureninase	465	52352	6.56	0	Nucleoplasm;Cytosol	Vertebral, cardiac, renal, and limb defects syndrome 2;Hydroxykynureninuria	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.	NA	Belongs to the kynureninase family.	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.;Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.;Tryptophan metabolism;Metabolic pathways;Tryptophan catabolism	PE1	2
+NX_Q16720	Plasma membrane calcium-transporting ATPase 3	1220	134197	5.45	10	Cell membrane	Spinocerebellar ataxia, X-linked 1	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.	Calcium signaling pathway;Salivary secretion;Pancreatic secretion;Ion transport by P-type ATPases;Reduction of cytosolic Ca++ levels;Ion homeostasis	PE1	X
+NX_Q16739	Ceramide glucosyltransferase	394	44854	7.94	5	Cytoplasm;Golgi apparatus membrane;Cell membrane	NA	Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (PubMed:8643456, PubMed:1532799). Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (PubMed:8643456). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction. They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway. They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope. The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity).	NA	Belongs to the glycosyltransferase 2 family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Glycosphingolipid metabolism	PE1	9
+NX_Q16740	ATP-dependent Clp protease proteolytic subunit, mitochondrial	277	30180	8.26	0	Mitochondrion matrix;Mitochondrion	Perrault syndrome 3	Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.	NA	Belongs to the peptidase S14 family.	NA	PE1	19
+NX_Q16760	Diacylglycerol kinase delta	1214	134525	7.62	0	Membrane;Cytoplasm;Cytosol	NA	May function as signaling molecule.;May be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis.	H domain is phosphorylated.	Belongs to the eukaryotic diacylglycerol kinase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Effects of PIP2 hydrolysis	PE1	2
+NX_Q16762	Thiosulfate sulfurtransferase	297	33429	6.77	0	Mitochondrion matrix;Mitochondrion	NA	Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.	NA	NA	Cysteine and methionine metabolism;Metabolic pathways;Sulfur relay system;Sulfide oxidation to sulfate;Degradation of cysteine and homocysteine	PE1	22
+NX_Q16763	Ubiquitin-conjugating enzyme E2 S	222	23845	8.45	0	Nucleoplasm;Cell membrane	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874).	Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	19
+NX_Q16769	Glutaminyl-peptide cyclotransferase	361	40877	6.12	0	Cytosol;Secreted	NA	Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.	NA	Belongs to the glutaminyl-peptide cyclotransferase family.	Neutrophil degranulation	PE1	2
+NX_Q16772	Glutathione S-transferase A3	222	25302	9.21	0	Cytoplasm	NA	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively.	NA	Belongs to the GST superfamily. Alpha family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation	PE1	6
+NX_Q16773	Kynurenine--oxoglutarate transaminase 1	422	47875	6.02	0	Cytoplasm;Cytosol	NA	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.	NA	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.;Tryptophan metabolism;Selenocompound metabolism;Metabolic pathways;Tryptophan catabolism;Glutamate and glutamine metabolism;Phenylalanine metabolism	PE1	9
+NX_Q16774	Guanylate kinase	197	21726	6.11	0	Photoreceptor inner segment;Cytosol	NA	Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664).	NA	Belongs to the guanylate kinase family.	Purine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates;Abacavir metabolism	PE1	1
+NX_Q16775	Hydroxyacylglutathione hydrolase, mitochondrial	308	33806	8.34	0	Cytoplasm;Mitochondrion matrix	NA	Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.	NA	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.	Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.;Pyruvate metabolism;Pyruvate metabolism	PE1	16
+NX_Q16777	Histone H2A type 2-C	129	13988	10.9	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).;Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.;Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Deiminated on Arg-4 in granulocytes upon calcium entry.	Belongs to the histone H2A family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;RMTs methylate histone arginines;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	1
+NX_Q16778	Histone H2B type 2-E	126	13920	10.31	0	Nucleus;Chromosome	NA	Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.;Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	1
+NX_Q16787	Laminin subunit alpha-3	3333	366649	7.03	0	Endoplasmic reticulum;Basement membrane	Laryngoonychocutaneous syndrome;Epidermolysis bullosa, junctional, Herlitz type	Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.;Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	NA	NA	Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer;Degradation of the extracellular matrix;ECM proteoglycans;Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly;Non-integrin membrane-ECM interactions;Laminin interactions;Anchoring fibril formation;MET activates PTK2 signaling	PE1	18
+NX_Q16790	Carbonic anhydrase 9	459	49698	4.64	1	Cell membrane;Nucleolus;Microvillus membrane;Cytosol;Nucleus	NA	Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.	Asn-346 bears high-mannose type glycan structures.	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Regulation of gene expression by Hypoxia-inducible Factor;Reversible hydration of carbon dioxide	PE1	9
+NX_Q16795	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	377	42510	9.81	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 26	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Required for proper complex I assembly (PubMed:28671271). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	Acetylated on lysine residues. BLOC1S1 is required for acetylation (PubMed:22309213). Acetylated by CLOCK in a circadian manner (PubMed:28985504).	Belongs to the complex I NDUFA9 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	12
+NX_Q16798	NADP-dependent malic enzyme, mitochondrial	604	67068	8.16	0	Mitochondrion matrix	NA	NA	NA	Belongs to the malic enzymes family.	Pyruvate metabolism;Metabolic pathways;Citric acid cycle (TCA cycle)	PE1	11
+NX_Q16799	Reticulon-1	776	83618	4.62	2	Endoplasmic reticulum;Endoplasmic reticulum membrane;Nucleus;Golgi apparatus membrane	NA	May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.	Isoforms RTN1-A and RTN1-B are phosphorylated.	NA	NA	PE1	14
+NX_Q16816	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	387	45024	6.4	0	NA	NA	Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity).	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	Calcium signaling pathway;Insulin signaling pathway;Glycogen breakdown (glycogenolysis)	PE1	7
+NX_Q16819	Meprin A subunit alpha	746	84419	5.43	1	Membrane	NA	NA	N-glycosylated; contains GlcNAc, galactose, mannose and a small amount of fucose.	NA	Protein digestion and absorption	PE1	6
+NX_Q16820	Meprin A subunit beta	701	79571	5.45	1	Secreted;Cell membrane	NA	Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.	N-glycosylated; contains high mannose and/or complex biantennary structures.;O-glycosylation protect the C-terminal region from proteolytic cleavage and diminish secretion, this seems to be specific to human.;Proteolytically activated by trypsin in the intestinal lumen and kallikrein-related peptidases in other tissues.	NA	Protein digestion and absorption	PE1	18
+NX_Q16821	Protein phosphatase 1 regulatory subunit 3A	1122	125767	4.91	1	Membrane	Diabetes mellitus, non-insulin-dependent	Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity).	Phosphorylation at Ser-46 by ISPK stimulates the dephosphorylation of glycogen synthase and phosphorylase kinase.	NA	Insulin signaling pathway	PE1	7
+NX_Q16822	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	640	70699	7.57	0	Mitochondrion	Mitochondrial phosphoenolpyruvate carboxykinase deficiency	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.	NA	Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.	Carbohydrate biosynthesis; gluconeogenesis.;Glycolysis / Gluconeogenesis;Citrate cycle (TCA cycle);Pyruvate metabolism;Metabolic pathways;PPAR signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Proximal tubule bicarbonate reclamation;Gluconeogenesis	PE1	14
+NX_Q16825	Tyrosine-protein phosphatase non-receptor type 21	1174	133281	8	0	Golgi apparatus;Cell membrane;Centriolar satellite;Nucleoplasm;Cytosol;Cytoskeleton	NA	NA	PTPN21 is phosphorylated by BMX (Phosphotyrosine:PTM-0255)	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.	NA	PE1	14
+NX_Q16827	Receptor-type tyrosine-protein phosphatase O	1216	138344	5.68	1	Membrane	Nephrotic syndrome 6	Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).	NA	Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.	Signaling by NTRK3 (TRKC)	PE1	12
+NX_Q16828	Dual specificity protein phosphatase 6	381	42320	4.75	0	Nucleoplasm;Cytosol;Cytoplasm	Hypogonadotropic hypogonadism 19 with or without anosmia	Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway;RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway;ERKs are inactivated	PE1	12
+NX_Q16829	Dual specificity protein phosphatase 7	419	44957	5.73	0	Cytoplasm	NA	Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway;RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway;ERKs are inactivated	PE1	3
+NX_Q16831	Uridine phosphorylase 1	310	33934	8.17	0	Nucleoplasm	NA	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	NA	Belongs to the PNP/UDP phosphorylase family.	Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.;Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine catabolism;Pyrimidine salvage	PE1	7
+NX_Q16832	Discoidin domain-containing receptor 2	855	96736	5.2	1	Cell membrane;Cytoskeleton	Spondyloepimetaphyseal dysplasia short limb-hand type;Warburg-Cinotti syndrome	Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.	N-glycosylated.;Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and subsequent autophosphorylation on additional tyrosine residues.;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	Non-integrin membrane-ECM interactions	PE1	1
+NX_Q16836	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	314	34294	8.88	0	Mitochondrion matrix;Mitochondrion	Familial hyperinsulinemic hypoglycemia 4;3-alpha-hydroxyacyl-CoA dehydrogenase deficiency	Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.	Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity).	Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid elongation;Fatty acid metabolism;Valine, leucine and isoleucine degradation;Lysine degradation;Tryptophan metabolism;Butanoate metabolism;Metabolic pathways;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA;Beta oxidation of hexanoyl-CoA to butanoyl-CoA;Beta oxidation of butanoyl-CoA to acetyl-CoA;Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	PE1	4
+NX_Q16842	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2	350	40173	8.59	1	Golgi stack membrane;Cytoplasmic vesicle;Secreted	NA	Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.	The soluble form derives from the membrane form by proteolytic processing.	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Glycosaminoglycan biosynthesis - keratan sulfate;Glycosphingolipid biosynthesis - globo series;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Sialic acid metabolism;Termination of O-glycan biosynthesis;Keratan sulfate biosynthesis	PE1	16
+NX_Q16849	Receptor-type tyrosine-protein phosphatase-like N	979	105848	6.67	1	Cell membrane;Perikaryon;Membrane;Endoplasmic reticulum;Endosome;Secretory vesicle membrane;Synapse;Axon;Nucleus	NA	ICA512-transmembrane fragment: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2.;Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity).;ICA512-cleaved cytosolic fragment: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (PubMed:15596545, PubMed:16622421, PubMed:18178618). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068).	Sumoylated at two sites including Lys-754. Sumoylation decreases interaction with STAT5.;O-glycosylated with core 1 or possibly core 8 glycans.;Subject to proteolytic cleavage at multiple sites (PubMed:11483505). Subject to cleavage on a pair of basic residues (By similarity). On exocytosis of secretory granules in pancreatic beta-cells ICA512-TMF is transiently inserted in the plasma-membrane and cleaved by mu-type calpain CPN1 to yield ICA512-CCF (By similarity).;N-glycosylated.	Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.	Type I diabetes mellitus	PE1	2
+NX_Q16850	Lanosterol 14-alpha demethylase	503	56806	8.72	1	Microsome membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.	NA	Belongs to the cytochrome P450 family.	Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.;Steroid biosynthesis;Metabolic pathways;Endogenous sterols;Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)	PE1	7
+NX_Q16851	UTP--glucose-1-phosphate uridylyltransferase	508	56940	8.15	0	Cytoplasm;Nucleoplasm;Mitochondrion;Centrosome	NA	Plays a central role as a glucosyl donor in cellular metabolic pathways.	NA	Belongs to the UDPGP type 1 family.	Pentose and glucuronate interconversions;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Glycogen synthesis;Formation of the active cofactor, UDP-glucuronate	PE1	2
+NX_Q16853	Membrane primary amine oxidase	763	84622	6.05	1	Golgi apparatus;Cytosol;Cell membrane	NA	Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.	N- and O-glycosylated.;Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.	Belongs to the copper/topaquinone oxidase family.	Glycine, serine and threonine metabolism;Tyrosine metabolism;Phenylalanine metabolism;beta-Alanine metabolism;Metabolic pathways;Phase I - Functionalization of compounds	PE1	17
+NX_Q16854	Deoxyguanosine kinase, mitochondrial	277	32056	8.76	0	Mitochondrion	Mitochondrial DNA depletion syndrome 3;Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4;Portal hypertension, non-cirrhotic	Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents.	NA	Belongs to the DCK/DGK family.	Purine metabolism;Metabolic pathways;Purine salvage	PE1	2
+NX_Q16864	V-type proton ATPase subunit F	119	13370	5.29	0	NA	NA	Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	NA	Belongs to the V-ATPase F subunit family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	7
+NX_Q16873	Leukotriene C4 synthase	150	16567	10.2	4	Nucleus outer membrane;Endoplasmic reticulum membrane;Nucleoplasm;Endoplasmic reticulum;Cytosol	NA	Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.	NA	Belongs to the MAPEG family.	Arachidonic acid metabolism;Metabolic pathways;Synthesis of Leukotrienes (LT) and Eoxins (EX);Synthesis of Lipoxins (LX);Synthesis of 5-eicosatetraenoic acids;Biosynthesis of maresin conjugates in tissue regeneration (MCTR);Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)	PE1	5
+NX_Q16875	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	520	59609	8.49	0	Nucleoplasm	NA	Synthesis and degradation of fructose 2,6-bisphosphate.	Phosphorylation by AMPK stimulates activity.	In the C-terminal section; belongs to the phosphoglycerate mutase family.	Fructose and mannose metabolism;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	10
+NX_Q16877	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4	469	54040	6.21	0	Nucleolus	NA	Synthesis and degradation of fructose 2,6-bisphosphate.	NA	In the C-terminal section; belongs to the phosphoglycerate mutase family.	Fructose and mannose metabolism;Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PE1	3
+NX_Q16878	Cysteine dioxygenase type 1	200	22972	6.11	0	Nucleoplasm;Cytosol	NA	Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.	The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.	Belongs to the cysteine dioxygenase family.	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.;Cysteine and methionine metabolism;Taurine and hypotaurine metabolism;Metabolic pathways;Degradation of cysteine and homocysteine	PE1	5
+NX_Q16880	2-hydroxyacylsphingosine 1-beta-galactosyltransferase	541	61438	9.54	1	Membrane;Mitochondrion	NA	Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.	NA	Belongs to the UDP-glycosyltransferase family.	Sphingolipid metabolism; galactosylceramide biosynthesis.;Sphingolipid metabolism;Metabolic pathways;Glycosphingolipid metabolism	PE1	4
+NX_Q16881	Thioredoxin reductase 1, cytoplasmic	649	70906	7.16	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Also mediates cell death induced by a combination of interferon-beta and retinoic acid.;May possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions.;Enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only.	ISGylated.;The N-terminus of isoform 5 is blocked.	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Pyrimidine metabolism;Selenocompound metabolism;Detoxification of Reactive Oxygen Species;PPARA activates gene expression;Uptake and function of diphtheria toxin;TP53 Regulates Metabolic Genes;Interconversion of nucleotide di- and triphosphates;Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;Metabolism of ingested MeSeO2H into MeSeH	PE1	12
+NX_Q16890	Tumor protein D53	204	22449	5.45	0	Cytosol;Cell junction;Cell membrane	NA	NA	NA	Belongs to the TPD52 family.	Golgi Associated Vesicle Biogenesis	PE1	6
+NX_Q16891	MICOS complex subunit MIC60	758	83678	6.08	1	Mitochondrion inner membrane;Mitochondrion	NA	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180).	NA	Belongs to the MICOS complex subunit Mic60 family.	Cristae formation	PE1	2
+NX_Q17R31	Putative deoxyribonuclease TATDN3	274	30333	6.67	0	Golgi apparatus;Nucleoplasm;Focal adhesion;Nucleus	NA	Putative deoxyribonuclease.	NA	Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.	NA	PE1	1
+NX_Q17R55	Protein FAM187B	369	42387	6.46	1	Membrane	NA	NA	NA	Belongs to the FAM187 family.	NA	PE1	19
+NX_Q17R60	Interphotoreceptor matrix proteoglycan 1	797	89387	4.79	0	Photoreceptor outer segment;Extracellular matrix;Secreted	Macular dystrophy, vitelliform, 4	May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.	The N-terminus is blocked.;Highly glycosylated (N- and O-linked carbohydrates and sialic acid).	NA	NA	PE1	6
+NX_Q17R89	Rho GTPase-activating protein 44	818	89247	6.13	0	Recycling endosome;Presynapse;Dendritic spine;Dendrite	NA	GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity).	NA	NA	Rho GTPase cycle	PE1	17
+NX_Q17R98	Zinc finger protein 827	1081	119165	6.43	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	4
+NX_Q17RA5	Putative uncharacterized protein C21orf62-AS1	79	8913	7.76	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_Q17RB0	Retrotransposon Gag-like protein 8B	113	13246	5.17	0	NA	NA	NA	NA	Belongs to the FAM127 family.	NA	PE1	X
+NX_Q17RB8	LON peptidase N-terminal domain and RING finger protein 1	773	86725	6.93	0	Cytosol;Centrosome;Cell membrane	NA	NA	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	8
+NX_Q17RC7	Exocyst complex component 3-like protein 4	722	79896	5.92	0	NA	NA	NA	NA	Belongs to the SEC6 family.	NA	PE1	14
+NX_Q17RD7	Synaptotagmin-16	645	72274	5.39	0	Cytosol	NA	May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.	NA	Belongs to the synaptotagmin family.	NA	PE1	14
+NX_Q17RF5	Odontogenesis associated phosphoprotein	130	15556	10.51	0	Secreted	Amelogenesis imperfecta, hypomaturation type, 2A4	May promote nucleation of hydroxyapatite.	NA	NA	NA	PE1	4
+NX_Q17RG1	BTB/POZ domain-containing protein KCTD19	926	104938	5.84	0	NA	NA	NA	NA	NA	NA	PE1	16
+NX_Q17RH7	Putative protein TPRXL	258	24139	11.48	0	NA	NA	NA	NA	NA	NA	PE5	3
+NX_Q17RM4	Coiled-coil domain-containing protein 142	750	81643	6.58	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q17RN3	Protein FAM98C	349	37329	6.89	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	Belongs to the FAM98 family.	NA	PE1	19
+NX_Q17RP2	Tigger transposable element-derived protein 6	521	58656	6.34	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus;Cytoskeleton	NA	NA	NA	Belongs to the tigger transposable element derived protein family.	NA	PE1	5
+NX_Q17RQ9	NTPase KAP family P-loop domain-containing protein 1	610	67780	9.13	3	Membrane	NA	NA	NA	NA	NA	PE1	19
+NX_Q17RR3	Pancreatic lipase-related protein 3	467	52254	8.56	0	Secreted	NA	NA	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Glycerolipid metabolism;Metabolic pathways;Digestion of dietary lipid	PE2	10
+NX_Q17RS7	Flap endonuclease GEN homolog 1	908	102884	8.04	0	Nucleoplasm;Nucleus	NA	Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation (PubMed:19020614, PubMed:26682650). Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction (PubMed:26578604). Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA (PubMed:28049850). Has also endonuclease activity on 5'-flap and replication fork (RF) DNA substrates (PubMed:26578604).	NA	Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.	Resolution of D-loop Structures through Holliday Junction Intermediates	PE1	2
+NX_Q17RW2	Collagen alpha-1(XXIV) chain	1714	175496	8.46	0	Extracellular matrix	NA	May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development.	NA	Belongs to the fibrillar collagen family.	Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;MET activates PTK2 signaling;Collagen chain trimerization	PE1	1
+NX_Q17RY0	Cytoplasmic polyadenylation element-binding protein 4	729	80152	6.7	0	Cytoplasm;Dendritic spine;Golgi apparatus;Perinuclear region;Growth cone;Endoplasmic reticulum;Nucleoplasm;Postsynaptic density;Cytoplasmic vesicle;Axon;Dendrite	NA	Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).	NA	Belongs to the RRM CPEB family.	NA	PE1	5
+NX_Q17RY6	Lymphocyte antigen 6K	165	18673	7.43	0	Cytoplasm;Cell membrane;Secreted;Nucleoplasm;Membrane raft;Acrosome	NA	Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth (PubMed:18089789).	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	8
+NX_Q18PE1	Protein Dok-7	504	53097	6.43	0	Nucleoplasm;Mitochondrion;Synapse;Cell membrane	Myasthenic syndrome, congenital, 10;Fetal akinesia deformation sequence 3	Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.	DOK7 is phosphorylated by MUSK (Phosphotyrosine:PTM-0255)	NA	NA	PE1	4
+NX_Q19AV6	Zinc finger SWIM domain-containing protein 7	140	15386	6.7	0	Cytosol;Nucleus	NA	Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.	NA	Belongs to the SWS1 family.	NA	PE1	17
+NX_Q19T08	Endothelial cell-specific chemotaxis regulator	205	21295	7.73	1	Cytoplasmic vesicle;Nucleoplasm;Cytoplasm;Cell membrane	NA	Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.	May be heavily O-glycosylated.	Belongs to the ECSCR family.	NA	PE1	5
+NX_Q1A5X6	IQ domain-containing protein J	159	18226	9.52	0	NA	NA	NA	NA	NA	NA	PE2	3
+NX_Q1A5X7	Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1	153	18091	5.71	0	Nucleus	NA	NA	NA	NA	NA	PE5	15
+NX_Q1AE95	Transmembrane protein 183B	376	42940	9.25	1	Membrane	NA	NA	NA	Belongs to the TMEM183 family.	NA	PE2	3
+NX_Q1ED39	Lysine-rich nucleolar protein 1	458	51589	9.86	0	Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	16
+NX_Q1EHB4	Sodium-coupled monocarboxylate transporter 2	618	67647	8.44	13	Endoplasmic reticulum;Apical cell membrane	NA	Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity).	NA	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Multifunctional anion exchangers	PE1	11
+NX_Q1HG43	Dual oxidase maturation factor 1	343	37815	6.3	5	Membrane	NA	May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1.	NA	Belongs to the DUOXA family.	NA	PE1	15
+NX_Q1HG44	Dual oxidase maturation factor 2	320	34787	8.51	5	Endoplasmic reticulum membrane	Thyroid dyshormonogenesis 5	Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis.	N-glycosylated.	Belongs to the DUOXA family.	NA	PE1	15
+NX_Q1KMD3	Heterogeneous nuclear ribonucleoprotein U-like protein 2	747	85105	4.85	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	11
+NX_Q1L5Z9	LON peptidase N-terminal domain and RING finger protein 2	754	83654	5.65	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	2
+NX_Q1L6U9	Prostate-associated microseminoprotein	139	14993	6.96	0	Cytoplasmic vesicle;Cytosol;Secreted	NA	NA	NA	Belongs to the beta-microseminoprotein family.	NA	PE1	9
+NX_Q1MSJ5	Centrosome and spindle pole-associated protein 1	1256	145522	6.37	0	Spindle pole;Spindle;Centriolar satellite;Centrosome	Joubert syndrome 21	May play a role in cell-cycle-dependent microtubule organization.	Phosphorylated. Phosphorylation increases in colcemide-treated cells.	NA	NA	PE1	8
+NX_Q1MX18	Protein inscuteable homolog	579	63469	5.37	0	Cytoplasm;Cell cortex	NA	May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity).	NA	NA	NA	PE1	11
+NX_Q1RMZ1	S-adenosylmethionine sensor upstream of mTORC1	405	46324	5.75	0	Cytosol	NA	S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).	NA	Belongs to the BMT2 family.	NA	PE1	7
+NX_Q1RN00	Putative uncharacterized protein LOC151760	199	22217	9.19	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_Q1T7F1	Putative chemokine-related protein B42	81	8815	6.05	0	Cytoplasm	NA	NA	NA	NA	NA	PE5	19
+NX_Q1W209	Embryonic stem cell-related gene protein	222	24186	9.39	0	Nucleus	NA	NA	NA	NA	NA	PE2	3
+NX_Q1W4C9	Serine protease inhibitor Kazal-type 13	94	11051	8.51	0	Nucleoplasm;Secreted;Cell membrane	NA	May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity).	NA	NA	NA	PE1	5
+NX_Q1W6H9	Protein FAM110C	321	33863	9.93	0	Spindle pole;Centrosome;Nucleus;Cytoskeleton	NA	May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.	NA	Belongs to the FAM110 family.	NA	PE1	2
+NX_Q1X8D7	Leucine-rich repeat-containing protein 36	754	83823	6.68	0	NA	NA	NA	NA	NA	NA	PE1	16
+NX_Q1XH10	SKI/DACH domain-containing protein 1	908	98148	8.68	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	Belongs to the DACH/dachshund family.	NA	PE1	10
+NX_Q1ZYL8	Izumo sperm-egg fusion protein 4	232	26510	7.18	0	Secreted	NA	NA	NA	Belongs to the Izumo family.	Acrosome Reaction and Sperm:Oocyte Membrane Binding	PE1	19
+NX_Q1ZZU3	DNA repair protein SWI5 homolog	235	26739	10.25	0	Nucleoplasm;Cytosol;Nucleus	NA	Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.	NA	Belongs to the SWI5/SAE3 family.	NA	PE1	9
+NX_Q24JP5	Transmembrane protein 132A	1023	110110	5.43	1	Endoplasmic reticulum membrane;Mitochondrion;Golgi apparatus membrane	NA	May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).	NA	Belongs to the TMEM132 family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	11
+NX_Q24JQ0	Transmembrane protein 241	296	32647	8.97	10	Membrane;Cytoplasmic vesicle;Golgi apparatus	NA	NA	NA	Belongs to the TMEM241 family.	NA	PE2	18
+NX_Q27J81	Inverted formin-2	1249	135624	5.26	0	Endoplasmic reticulum;Perinuclear region;Nucleus	Charcot-Marie-Tooth disease, dominant, intermediate type, E;Focal segmental glomerulosclerosis 5	Severs actin filaments and accelerates their polymerization and depolymerization.	NA	Belongs to the formin homology family.	NA	PE1	14
+NX_Q29974	HLA class II histocompatibility antigen, DRB1-16 beta chain	266	30030	7.64	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;Lysosome membrane;trans-Golgi network membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_Q29980	MHC class I polypeptide-related sequence B	383	42646	6.5	1	Cell membrane	Rheumatoid arthritis	Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.	Proteolytically cleaved and released from the cell surface of tumor cells.	Belongs to the MHC class I family. MIC subfamily.	Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	6
+NX_Q29983	MHC class I polypeptide-related sequence A	383	42915	6.49	1	Cytoplasm;Cell membrane	Psoriatic arthritis;Psoriasis 1	Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.	N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.;Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.	Belongs to the MHC class I family. MIC subfamily.	Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	6
+NX_Q29RF7	Sister chromatid cohesion protein PDS5 homolog A	1337	150830	8.15	0	Nucleoplasm;Nucleus	NA	Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.	NA	Belongs to the PDS5 family.	Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion	PE1	4
+NX_Q2HXU8	C-type lectin domain family 12 member B	276	31616	5.5	1	Cell membrane	NA	Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.	NA	NA	NA	PE1	12
+NX_Q2I0M4	Leucine-rich repeat-containing protein 26	334	34857	9.6	1	Cytoskeleton;Nucleolus;Cell membrane	NA	Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.	NA	NA	NA	PE1	9
+NX_Q2I0M5	R-spondin-4	234	26171	9.38	0	Secreted	Nail disorder, non-syndromic congenital, 4	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076).	Tyr-112 may be phosphorylated; however as this position is probably extracellular, the vivo relevance is not proven.	Belongs to the R-spondin family.	Regulation of FZD by ubiquitination	PE1	20
+NX_Q2KHM9	Protein moonraker	967	109407	7.6	0	Cytosol;Centrosome;Centriolar satellite;Centriole	Orofaciodigital syndrome 15	Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806).	NA	NA	NA	PE1	17
+NX_Q2KHN1	RING finger protein 151	245	27412	9.07	0	Cytoplasm;Nucleus	NA	May be involved in acrosome formation of spermatids.	NA	NA	NA	PE1	16
+NX_Q2KHR2	DNA-binding protein RFX7	1363	146896	6.29	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	NA	NA	Belongs to the RFX family.	NA	PE1	15
+NX_Q2KHR3	Glutamine and serine-rich protein 1	1735	189972	6.61	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	11
+NX_Q2KHT3	Protein CLEC16A	1053	117715	5.55	0	Cytoplasmic vesicle;Nucleoplasm;Lysosome membrane;Endosome membrane	Diabetes mellitus, insulin-dependent	Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.	NA	Belongs to the CLEC16A/gop-1 family.	NA	PE1	16
+NX_Q2KHT4	Germ cell-specific gene 1 protein	349	39248	8.25	4	Endoplasmic reticulum membrane	NA	May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.	NA	Belongs to the GSG1 family.	NA	PE1	12
+NX_Q2KJY2	Kinesin-like protein KIF26B	2108	223883	8.76	0	Cytoplasm;Cell membrane;Cytoskeleton	NA	Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity).	Polyubiquitinated by NEDD4, resulting in proteasomal degradation.;Phosphorylation at Thr-1855 and Ser-1958 by CDKs, mainly CDK2 and CDK5, enhances the interaction with NEDD4, polyubiquitination, and subsequent proteasomal degradation. Phosphorylation occurs upon loss of interaction with microtubules (By similarity).	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	1
+NX_Q2L4Q9	Serine protease 53	553	58410	5.46	0	Secreted	NA	In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.	NA	Belongs to the peptidase S1 family.	NA	PE2	16
+NX_Q2LD37	Transmembrane protein KIAA1109	5005	555482	6.12	1	Membrane;Nucleoplasm;Centrosome	Alkuraya-Kucinskas syndrome	NA	NA	NA	NA	PE1	4
+NX_Q2M1K9	Zinc finger protein 423	1284	144605	6.43	0	Nucleoplasm;Nucleus	Joubert syndrome 19;Nephronophthisis 14	Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	16
+NX_Q2M1P5	Kinesin-like protein KIF7	1343	150587	6.37	0	Cilium;Cilium basal body	Al-Gazali-Bakalinova syndrome;Hydrolethalus syndrome 2;Joubert syndrome 12;Bardet-Biedl syndrome;Acrocallosal syndrome	Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity).	Polyubiquitinated by UBR3.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.	Hedgehog 'on' state;Hedgehog 'off' state	PE1	15
+NX_Q2M1V0	Intestine-specific homeobox	245	27011	8.91	0	Nucleoplasm;Nucleus	NA	Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine (By similarity).	NA	NA	NA	PE2	22
+NX_Q2M1Z3	Rho GTPase-activating protein 31	1444	156985	5.55	0	Lamellipodium;Focal adhesion	Adams-Oliver syndrome 1	Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration.	Phosphorylation on Thr-789 reduces GAP activity.	NA	Rho GTPase cycle	PE1	3
+NX_Q2M218	Zinc finger protein 630	657	76094	9.07	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	X
+NX_Q2M238	Putative RRN3-like protein RRN3P1	152	17255	9.03	0	NA	NA	NA	NA	Belongs to the RRN3 family.	NA	PE5	16
+NX_Q2M243	Coiled-coil domain-containing protein 27	656	75354	5.53	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q2M296	Methenyltetrahydrofolate synthase domain-containing protein	383	42173	8.93	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	16
+NX_Q2M2D7	TBC1 domain family member 28	210	24072	9.69	0	NA	NA	NA	NA	NA	NA	PE2	17
+NX_Q2M2E3	Outer dense fiber protein 4	257	29233	6.71	3	Membrane	NA	Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.	NA	NA	NA	PE1	17
+NX_Q2M2E5	Uncharacterized protein C5orf64	130	14817	9.54	0	Secreted	NA	NA	NA	NA	NA	PE2	5
+NX_Q2M2H8	Probable maltase-glucoamylase 2	2515	277990	5.02	1	Membrane;Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the glycosyl hydrolase 31 family.	NA	PE1	7
+NX_Q2M2I3	Protein FAM83E	478	51780	9.42	0	NA	NA	May play a role in MAPK signaling.	NA	Belongs to the FAM83 family.	NA	PE1	19
+NX_Q2M2I5	Keratin, type I cytoskeletal 24	525	55087	4.89	0	Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q2M2I8	AP2-associated protein kinase 1	961	103885	6.16	0	Presynapse;Cell membrane;Clathrin-coated pit;Cytosol	NA	Display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.;Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis.	Autophosphorylated.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	2
+NX_Q2M2W7	UPF0450 protein C17orf58	97	11219	10.7	0	Cytosol;Cell membrane	NA	NA	NA	Belongs to the UPF0450 family.	NA	PE1	17
+NX_Q2M2Z5	Centrosomal protein kizuna	673	75111	5.44	0	Centrosome;Cilium basal body	Retinitis pigmentosa 69	Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.	Phosphorylation at Thr-379 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization.	Belongs to the kizuna family.	NA	PE1	20
+NX_Q2M329	Coiled-coil domain-containing protein 96	555	62711	4.92	0	Centrosome	NA	NA	NA	NA	NA	PE1	4
+NX_Q2M385	Macrophage-expressed gene 1 protein	716	78587	7.77	1	Cytoplasmic vesicle membrane	NA	Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores (By similarity). By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (By similarity). Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (PubMed:23753625, PubMed:26402460, PubMed:30609079). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity).	Monoubiquitinated in response to bacterial infection; ubiquitination is required for vesicular localization and antibacterial activity and can be blocked by bacterial cell cycle inhibiting factor (cif) (By similarity).	Belongs to the MPEG1 family.	NA	PE1	11
+NX_Q2M389	WASH complex subunit 4	1173	136403	7.1	0	Nucleoplasm;Early endosome	Mental retardation, autosomal recessive 43	Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in the regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093).	NA	Belongs to the SWIP family.	NA	PE1	12
+NX_Q2M3A8	Putative uncharacterized protein MRGPRG-AS1	158	16456	6.69	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q2M3C6	Transmembrane protein 266	531	58444	4.63	4	Cytosol;Perikaryon;Dendrite;Cell membrane	NA	Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529). Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529). Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529). Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529).	NA	NA	NA	PE1	15
+NX_Q2M3C7	A-kinase anchor protein SPHKAP	1700	186456	5.04	0	Cytoplasm	NA	Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.	NA	Belongs to the AKAP110 family.	NA	PE1	2
+NX_Q2M3D2	Exocyst complex component 3-like protein 2	409	45859	7.65	0	Nucleoplasm;Golgi apparatus;Cytosol;Cytoplasmic vesicle	NA	NA	NA	Belongs to the SEC6 family.	NA	PE1	19
+NX_Q2M3G0	ATP-binding cassette sub-family B member 5	1257	138641	7.29	11	Cell membrane	NA	Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.	NA	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.	ABC transporters;ABC-family proteins mediated transport	PE1	7
+NX_Q2M3G4	Protein Shroom1	852	90786	5.81	0	Cytoplasmic vesicle;Cytoskeleton	NA	May be involved in the assembly of microtubule arrays during cell elongation.	NA	Belongs to the shroom family.	NA	PE1	5
+NX_Q2M3M2	Sodium/glucose cotransporter 4	681	74073	6.71	14	Membrane;Cytosol;Cytoskeleton	NA	Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose.	NA	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Cellular hexose transport	PE1	1
+NX_Q2M3R5	Solute carrier family 35 member G1	365	39836	8.46	10	Endoplasmic reticulum membrane;Cell membrane	NA	May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.	NA	Belongs to the TMEM20 family.	NA	PE1	10
+NX_Q2M3T9	Hyaluronidase-4	481	54249	8.68	2	Membrane	NA	Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.	NA	Belongs to the glycosyl hydrolase 56 family.	Glycosaminoglycan degradation;Metabolic pathways	PE1	7
+NX_Q2M3V2	Ankyrin repeat domain-containing protein SOWAHA	549	57443	10.19	0	NA	NA	NA	NA	Belongs to the SOWAH family.	NA	PE1	5
+NX_Q2M3W8	Zinc finger protein 181	571	65842	9.12	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q2M3X9	Zinc finger protein 674	581	67199	9.32	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	X
+NX_Q2M5E4	Regulator of G-protein signaling 21	152	17671	6.6	0	NA	NA	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.	NA	NA	G alpha (i) signalling events;G alpha (q) signalling events	PE2	1
+NX_Q2MJR0	Sprouty-related, EVH1 domain-containing protein 3	410	42670	8.67	0	Membrane;Nucleoplasm;Cytosol;Cell membrane	NA	Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.	Phosphorylated on tyrosine.	NA	Regulation of RAS by GAPs;Signaling by RAS mutants	PE1	19
+NX_Q2MKA7	R-spondin-1	263	28959	9.46	0	Secreted;Nucleus	Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805).	NA	Belongs to the R-spondin family.	Regulation of FZD by ubiquitination	PE1	1
+NX_Q2MV58	Tectonic-1	587	63570	5.32	0	Nucleoplasm;Secreted;Cilium basal body;Cytoskeleton	Joubert syndrome 13	Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity).	NA	Belongs to the tectonic family.	Anchoring of the basal body to the plasma membrane	PE1	12
+NX_Q2NKJ3	CST complex subunit CTC1	1217	134609	8.23	0	Telomere;Nucleus	Cerebroretinal microangiopathy with calcifications and cysts 1	Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Involved in telomere maintenance (PubMed:19854131, PubMed:22863775). Involved in genome stability (PubMed:22863775). May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity).	NA	Belongs to the CTC1 family.	NA	PE1	17
+NX_Q2NKQ1	Small G protein signaling modulator 1	1148	129718	5.43	0	trans-Golgi network;Cytoplasmic vesicle membrane;Cytoplasm	NA	Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B.	NA	Belongs to the RUTBC family.	NA	PE1	22
+NX_Q2NKX8	DNA excision repair protein ERCC-6-like	1250	141103	5.19	0	Chromosome;Nucleoplasm;Centromere;Centrosome;Cytosol;Kinetochore	NA	DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin (PubMed:17218258). Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328).	Phosphorylation by PLK1 prevents the association with chromosome arms and restricts its localization to the kinetochore-centromere region.	Belongs to the SNF2/RAD54 helicase family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	X
+NX_Q2NKX9	UPF0561 protein C2orf68	166	18751	8.44	0	Nucleoplasm;Nucleus membrane;Nucleolus;Mitochondrion	NA	NA	NA	Belongs to the UPF0561 family.	NA	PE1	2
+NX_Q2NL67	Protein mono-ADP-ribosyltransferase PARP6	630	71115	8.6	0	Cell membrane	NA	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.	Auto-mono-ADP-ribosylated.	NA	Nicotinamide salvaging	PE1	15
+NX_Q2NL68	Proline and serine-rich protein 3	480	51075	6.63	0	Golgi apparatus	NA	NA	NA	NA	NA	PE1	19
+NX_Q2NL82	Pre-rRNA-processing protein TSR1 homolog	804	91810	6.98	0	Nucleoplasm;Nucleolus	NA	Required during maturation of the 40S ribosomal subunit in the nucleolus.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	17
+NX_Q2NL98	Vimentin-type intermediate filament-associated coiled-coil protein	169	18348	5.44	0	Cytoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q2PPJ7	Ral GTPase-activating protein subunit alpha-2	1873	210770	5.74	0	Cytoplasm;Cytosol;Cell membrane	NA	Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.	NA	NA	Translocation of SLC2A4 (GLUT4) to the plasma membrane	PE1	20
+NX_Q2PZI1	Probable C-mannosyltransferase DPY19L1	675	77319	9.13	11	Membrane;Cytoplasmic vesicle	NA	Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.	NA	Belongs to the dpy-19 family.	NA	PE1	7
+NX_Q2Q1W2	E3 ubiquitin-protein ligase TRIM71	868	93385	7.57	0	P-body;Focal adhesion;Cytoskeleton;Cell membrane	NA	E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233).	Autoubiquitinated.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	3
+NX_Q2QD12	Ribulose-phosphate 3-epimerase-like protein 1	228	25023	5.21	0	NA	NA	Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.	NA	Belongs to the ribulose-phosphate 3-epimerase family.	Carbohydrate degradation.;Pentose phosphate pathway	PE1	10
+NX_Q2QGD7	Zinc finger protein ZXDC	858	89988	8.48	0	Nucleolus;Nucleus	NA	Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.	Sumoylated at Lys-660 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain.	Belongs to the ZXD family.	NA	PE1	3
+NX_Q2QL34	Mpv17-like protein	196	22116	9.92	4	Peroxisome membrane;Cytoplasmic vesicle	NA	Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes.	NA	Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisome	PE1	16
+NX_Q2T9J0	Peroxisomal leader peptide-processing protease	566	59309	5.82	0	Nucleoplasm;Cytosol;Peroxisome;Centrosome	NA	Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.	Self-cleavage gives rise to an N-terminal 15-kDa fragment and C-terminal 45-kDa fragment upon import into the peroxisomes. The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.	Belongs to the peptidase S1B family.	Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins	PE1	10
+NX_Q2T9K0	Transmembrane protein 44	475	52201	8.12	7	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	3
+NX_Q2T9L4	Inhibitory synaptic factor 1	293	31928	4.91	0	Nucleoplasm;Cytosol;Postsynaptic density	NA	Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.	NA	Belongs to the INSYN1 family.	NA	PE2	15
+NX_Q2TAA2	Isoamyl acetate-hydrolyzing esterase 1 homolog	248	27599	5.13	0	Nucleoplasm	NA	Probable lipase.	NA	Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.	NA	PE1	2
+NX_Q2TAA5	GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase	492	55651	8.78	2	Endoplasmic reticulum;Endoplasmic reticulum membrane	Congenital disorder of glycosylation 1P	Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain.	NA	Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.	N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG11 causes ALG11-CDG (CDG-1p)	PE1	13
+NX_Q2TAA8	Translin-associated factor X-interacting protein 1	658	76773	4.99	0	Nucleoplasm;Cytosol;Perinuclear region	NA	Possible role in spermatogenesis.	NA	NA	NA	PE1	16
+NX_Q2TAC2	Coiled-coil domain-containing protein 57	915	103039	6.13	0	Cytosol;Centriolar satellite;Cytoskeleton	NA	NA	NA	NA	NA	PE1	17
+NX_Q2TAC6	Kinesin-like protein KIF19	998	111332	8.87	0	Cell membrane;Centrosome;Cilium;Cytoskeleton	NA	Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	17
+NX_Q2TAK8	PWWP domain-containing DNA repair factor 3A	710	78636	8.83	0	Nucleoplasm;Cytosol;Nucleus	NA	Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.	NA	Belongs to the PWWP3A family.	NA	PE1	19
+NX_Q2TAL5	Smoothelin-like protein 2	461	50196	8.8	0	NA	NA	NA	NA	Belongs to the smoothelin family.	NA	PE1	17
+NX_Q2TAL6	Brorin	325	35282	5.29	0	Basement membrane;Synapse	NA	BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).	NA	NA	NA	PE1	7
+NX_Q2TAL8	Glutamine-rich protein 1	776	86436	5.59	0	Nucleoplasm	Ververi-Brady syndrome	NA	NA	NA	NA	PE1	3
+NX_Q2TAM9	Tumor suppressor candidate gene 1 protein	212	23390	11.18	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	9
+NX_Q2TAP0	Golgin subfamily A member 7B	167	18335	5.77	0	Golgi apparatus membrane	NA	May be involved in protein transport from Golgi to cell surface.	NA	Belongs to the ERF4 family.	NA	PE1	10
+NX_Q2TAY7	WD40 repeat-containing protein SMU1	513	57544	6.74	0	Cytoplasm;Nucleus speckle;Nucleus;Cytoplasmic vesicle	NA	(Microbial infection) Required, together with IK, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.;Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (PubMed:24945353). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).	NA	Belongs to the WD repeat SMU1 family.	NA	PE1	9
+NX_Q2TAZ0	Autophagy-related protein 2 homolog A	1938	212860	5.57	0	Lipid droplet;Preautophagosomal structure membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Involved in autophagosome assembly, regulating the size of nascent autophagosomes (PubMed:28561066). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066).	NA	Belongs to the ATG2 family.	NA	PE1	11
+NX_Q2TB10	Zinc finger protein 800	664	75236	9.54	0	Nucleolus;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	7
+NX_Q2TB18	Protein asteroid homolog 1	679	77093	8.39	0	Endoplasmic reticulum	NA	Possible role in EGF receptor signaling.	NA	Belongs to the asteroid family.	NA	PE1	3
+NX_Q2TB90	Hexokinase HKDC1	917	102545	6.77	0	Mitochondrion membrane;Mitochondrion	NA	Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (PubMed:30517626). Has low glucose phosphorylating activity compared to other hexokinases (PubMed:30517626). Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity).	NA	Belongs to the hexokinase family.	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.;Carbohydrate metabolism; hexose metabolism.;Glycolysis / Gluconeogenesis;Fructose and mannose metabolism;Galactose metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Butirosin and neomycin biosynthesis;Metabolic pathways;Insulin signaling pathway;Type II diabetes mellitus;Carbohydrate digestion and absorption	PE1	10
+NX_Q2TBA0	Kelch-like protein 40	621	69257	5.15	0	Cytoplasm;A band;I band	Nemaline myopathy 8	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity).	NA	Belongs to the KLHL40 family.	NA	PE1	3
+NX_Q2TBC4	Prickle-like protein 4	344	37551	5.47	0	Spindle;Centriolar satellite	NA	NA	NA	Belongs to the prickle / espinas / testin family.	NA	PE2	6
+NX_Q2TBE0	CWF19-like protein 2	894	103787	8.78	0	Cytosol;Nucleus speckle	NA	NA	NA	Belongs to the CWF19 family.	NA	PE1	11
+NX_Q2TBF2	WSC domain-containing protein 2	565	63817	8.99	1	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the WSCD family.	NA	PE1	12
+NX_Q2TV78	Putative macrophage stimulating 1-like protein	715	79694	8.16	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family. Plasminogen subfamily.	NA	PE1	1
+NX_Q2UY09	Collagen alpha-1(XXVIII) chain	1125	116657	6.1	0	Nucleoplasm;Basement membrane;Cytosol	NA	May act as a cell-binding protein.	NA	Belongs to the VWA-containing collagen family.	Collagen biosynthesis and modifying enzymes;Collagen chain trimerization	PE1	7
+NX_Q2V2M9	FH1/FH2 domain-containing protein 3	1422	158613	5.7	0	Z line;Cytoskeleton	NA	May play a role in actin filament polymerization in cardiomyocytes.;Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity).	Phosphorylated on Thr-1474 and Thr-1476 by CK2.	Belongs to the formin homology family.	NA	PE1	18
+NX_Q2VIQ3	Chromosome-associated kinesin KIF4B	1234	140035	5.88	0	Nucleus matrix;Cytoskeleton	NA	Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.	MHC class II antigen presentation;Kinesins;Recycling pathway of L1;COPI-dependent Golgi-to-ER retrograde traffic	PE1	5
+NX_Q2VIR3	Eukaryotic translation initiation factor 2 subunit 3B	472	51229	8.67	0	NA	NA	As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.	NA	PE1	12
+NX_Q2VPA4	Complement component receptor 1-like protein	569	62714	6.95	0	Membrane;Cytoplasm;Secreted	NA	NA	NA	Belongs to the receptors of complement activation (RCA) family.	NA	PE1	1
+NX_Q2VPB7	AP-5 complex subunit beta-1	878	93949	5.61	0	Golgi apparatus;Nucleoplasm;Cytoplasmic vesicle	NA	As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.	NA	NA	NA	PE1	11
+NX_Q2VPJ9	Leucine-rich repeat-containing protein 75B	315	34740	9.42	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the LRRC75 family.	NA	PE2	22
+NX_Q2VPK5	Cytoplasmic tRNA 2-thiolation protein 2	515	56107	5.94	0	Cytoplasm	Microcephaly, facial dysmorphism, renal agenesis, and ambiguous genitalia syndrome	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	NA	Belongs to the CTU2/NCS2 family.	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.;Sulfur relay system;tRNA modification in the nucleus and cytosol	PE1	16
+NX_Q2VWA4	SKI family transcriptional corepressor 2	1001	104235	6.02	0	Cytoplasm;Nucleus	NA	Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system.	NA	Belongs to the SKI family.	NA	PE1	18
+NX_Q2VWP7	Protogenin	1150	127076	7.37	1	Membrane;Cytoplasmic vesicle;Cytosol;Cell membrane	NA	May play a role in anteroposterior axis elongation.	NA	Belongs to the immunoglobulin superfamily. DCC family.	NA	PE1	15
+NX_Q2VY69	Zinc finger protein 284	593	69019	8.77	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q2VYF4	LETM1 domain-containing protein LETM2, mitochondrial	491	55921	9.31	1	Nucleoplasm;Cytosol;Mitochondrion inner membrane;Nucleus	NA	NA	NA	NA	NA	PE1	8
+NX_Q2WEN9	Carcinoembryonic antigen-related cell adhesion molecule 16	425	45873	5.94	0	Secreted	Deafness, autosomal dominant, 4B;Deafness, autosomal recessive, 113	Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.	NA	Belongs to the immunoglobulin superfamily. CEA family.	NA	PE1	19
+NX_Q2WGJ6	Kelch-like protein 38	581	65541	8.19	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	8
+NX_Q2WGJ8	Transmembrane protein 249	235	27046	9.88	2	Membrane	NA	NA	NA	NA	NA	PE1	8
+NX_Q2WGJ9	Fer-1-like protein 6	1857	209308	5.98	1	Membrane	NA	NA	NA	Belongs to the ferlin family.	NA	PE1	8
+NX_Q2WGN9	GRB2-associated-binding protein 4	574	62367	7.35	0	NA	NA	NA	NA	Belongs to the GAB family.	NA	PE2	22
+NX_Q2Y0W8	Electroneutral sodium bicarbonate exchanger 1	1093	122938	6.22	11	Membrane;Cell membrane	NA	Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.	NA	Belongs to the anion exchanger (TC 2.A.31) family.	Bicarbonate transporters	PE1	12
+NX_Q2YD98	UV-stimulated scaffold protein A	709	80591	5.93	0	Nucleoplasm;Chromosome	UV-sensitive syndrome 3	Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.	Monoubiquitinated: ubiquitination does not increase in response to UV.	Belongs to the UVSSA family.	Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER	PE1	4
+NX_Q30134	HLA class II histocompatibility antigen, DRB1-8 beta chain	266	30004	6.66	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;trans-Golgi network membrane;Lysosome membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_Q30154	HLA class II histocompatibility antigen, DR beta 5 chain	266	30056	6.45	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;Lysosome membrane;trans-Golgi network membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to down-regulation of MHC class II.	Belongs to the MHC class II family.	Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Hematopoietic cell lineage;Intestinal immune network for IgA production;Type I diabetes mellitus;Leishmaniasis;Toxoplasmosis;Staphylococcus aureus infection;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis;MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_Q30167	HLA class II histocompatibility antigen, DRB1-10 beta chain	266	30002	7.66	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;trans-Golgi network membrane;Lysosome membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_Q30201	Hereditary hemochromatosis protein	348	40108	6.12	1	Nucleoplasm;Cell membrane	Microvascular complications of diabetes 7;Variegate porphyria;Hemochromatosis 1	Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.	NA	Belongs to the MHC class I family.	Transferrin endocytosis and recycling	PE1	6
+NX_Q309B1	Tripartite motif-containing protein 16-like protein	348	40306	5.86	0	Cytoplasm	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE1	17
+NX_Q30KP8	Beta-defensin 136	78	8755	9.18	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	8
+NX_Q30KP9	Beta-defensin 135	77	8754	9.54	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	8
+NX_Q30KQ1	Beta-defensin 133	61	7213	9.06	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	6
+NX_Q30KQ4	Beta-defensin 116	102	11544	8.71	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	20
+NX_Q30KQ5	Beta-defensin 115	88	10071	8.77	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	20
+NX_Q30KQ6	Beta-defensin 114	69	8318	7.5	0	Secreted	NA	Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	6
+NX_Q30KQ7	Beta-defensin 113	82	9640	9.1	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	6
+NX_Q30KQ8	Beta-defensin 112	113	12991	8.82	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	6
+NX_Q30KQ9	Beta-defensin 110	67	8001	9.06	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	6
+NX_Q30KR1	Putative beta-defensin 109B	87	9886	8.91	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins	PE5	8
+NX_Q32M45	Anoctamin-4	955	111462	8.45	8	Cell membrane	NA	Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity).	NA	Belongs to the anoctamin family.	Stimuli-sensing channels	PE1	12
+NX_Q32M78	Zinc finger protein 699	642	73956	8.6	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q32M84	BTB/POZ domain-containing protein 16	506	58481	9.29	0	Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	10
+NX_Q32M88	Protein-glucosylgalactosylhydroxylysine glucosidase	737	80655	5.11	0	Cytosol	NA	Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.	NA	Belongs to the glycosyl hydrolase 65 family.	NA	PE1	11
+NX_Q32M92	Uncharacterized protein C15orf32	178	20262	9.34	0	NA	NA	NA	NA	NA	NA	PE2	15
+NX_Q32MH5	Protein FAM214A	1076	121670	8.12	0	Nucleoplasm	NA	NA	NA	Belongs to the FAM214 family.	NA	PE1	15
+NX_Q32MK0	Myosin light chain kinase 3	819	88393	5.76	0	Nucleoplasm;Cytoplasm;Cytoplasmic vesicle	NA	Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).	Phosphorylated on serine residues.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	Calcium signaling pathway;Vascular smooth muscle contraction;Focal adhesion;Regulation of actin cytoskeleton;Gastric acid secretion	PE1	16
+NX_Q32MQ0	Zinc finger protein 750	723	77361	8.45	0	Nucleus	Seborrhea-like dermatitis with psoriasiform elements	Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.	NA	NA	Generic Transcription Pathway	PE1	17
+NX_Q32MZ4	Leucine-rich repeat flightless-interacting protein 1	808	89253	4.59	0	Cytoplasm;Cytosol;Nucleus	NA	Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.	NA	Belongs to the LRRFIP family.	Signaling by FGFR1 in disease;Signaling by cytosolic FGFR1 fusion mutants;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	PE1	2
+NX_Q32NB8	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial	556	62730	9.08	0	Cytoplasmic vesicle;Cell junction;Mitochondrion;Cytoskeleton	NA	Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.	NA	Belongs to the CDP-alcohol phosphatidyltransferase class-II family.	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PG	PE1	17
+NX_Q32NC0	UPF0711 protein C18orf21	220	24827	10.27	0	Nucleolus;Cell membrane	NA	NA	NA	Belongs to the UPF0711 family.	NA	PE1	18
+NX_Q32P28	Prolyl 3-hydroxylase 1	736	83394	5.05	0	Endoplasmic reticulum;Cytoplasmic vesicle;Extracellular matrix;Nucleolus	Osteogenesis imperfecta 8	Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.	O-glycosylated; chondroitin sulfate.	Belongs to the leprecan family.	Collagen biosynthesis and modifying enzymes	PE1	1
+NX_Q32P41	tRNA (guanine(37)-N1)-methyltransferase	509	58246	8.78	0	Cytoplasm;Mitochondrion matrix;Nucleolus;Nucleoplasm;Nucleus	Combined oxidative phosphorylation deficiency 26	Involved in mitochondrial tRNA methylation (PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.	Synthesis of wybutosine at G37 of tRNA(Phe)	PE1	14
+NX_Q32P44	Echinoderm microtubule-associated protein-like 3	896	95197	6.69	0	Cytoskeleton	NA	May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.	NA	Belongs to the WD repeat EMAP family.	NA	PE1	11
+NX_Q32P51	Heterogeneous nuclear ribonucleoprotein A1-like 2	320	34225	9.08	0	Cytoplasm;Nucleus	NA	Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.	NA	NA	Spliceosome	PE1	13
+NX_Q32Q52	Uncharacterized protein C12orf74	190	21196	8.68	0	NA	NA	NA	NA	NA	NA	PE2	12
+NX_Q32ZL2	Phospholipid phosphatase-related protein type 5	321	35427	6.58	6	Cytosol;Cell membrane	NA	Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction.	NA	Belongs to the PA-phosphatase related phosphoesterase family.	Lysosphingolipid and LPA receptors	PE2	1
+NX_Q330K2	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6	333	38176	9.44	0	Cytoplasm;Mitochondrion inner membrane;Nucleus	Mitochondrial complex I deficiency, nuclear type 17	Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1.	NA	Belongs to the NDUFAF6 family.	Complex I biogenesis	PE1	8
+NX_Q33E94	Transcription factor RFX4	735	83368	6.38	0	Nucleoplasm;Nucleus	NA	Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development.	NA	Belongs to the RFX family.	NA	PE1	12
+NX_Q38SD2	Leucine-rich repeat serine/threonine-protein kinase 1	2015	225393	6.25	0	Cytoplasm;Cytosol;Mitochondrion	NA	NA	Autophosphorylated	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.	NA	PE1	15
+NX_Q3B726	DNA-directed RNA polymerase I subunit RPA43	338	37432	6.53	0	Nucleoplasm;Nucleolus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.	NA	Belongs to the eukaryotic RPA43 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;B-WICH complex positively regulates rRNA expression	PE1	7
+NX_Q3B7I2	Protein canopy homolog 1	92	10960	4.92	0	NA	NA	NA	NA	Belongs to the canopy family.	NA	PE2	7
+NX_Q3B7J2	Glucose-fructose oxidoreductase domain-containing protein 2	385	42255	6.02	0	Nucleoplasm;Cytosol;Extracellular matrix	NA	Promotes matrix assembly.	NA	Belongs to the Gfo/Idh/MocA family.	NA	PE1	16
+NX_Q3B7S5	Small integral membrane protein 21	101	11722	10.62	1	Membrane	NA	NA	NA	NA	NA	PE2	18
+NX_Q3B7T1	Erythroid differentiation-related factor 1	1238	138528	5.93	0	Nucleoplasm;Cytosol;Centrosome;Nucleus	NA	Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.	NA	NA	NA	PE1	10
+NX_Q3B7T3	Protein BEAN1	259	28626	7.8	1	Membrane;Nucleoplasm;Centrosome	Spinocerebellar ataxia 31	NA	NA	NA	NA	PE1	16
+NX_Q3B820	Protein FAM161A	660	76752	8.21	0	Cilium;Cilium basal body	Retinitis pigmentosa 28	Involved in ciliogenesis.	NA	Belongs to the FAM161 family.	NA	PE1	2
+NX_Q3B8N2	Galectin-9B	356	39660	9.6	0	NA	NA	Binds galactosides.	NA	NA	NA	PE1	17
+NX_Q3B8N5	Prospero homeobox protein 2	592	65586	9.28	0	Nucleus	NA	Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity).	NA	Belongs to the Prospero homeodomain family.	NA	PE2	14
+NX_Q3BBV0	Neuroblastoma breakpoint family member 1	1214	139258	4.74	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE1	1
+NX_Q3BBV2	Putative neuroblastoma breakpoint family member 8	869	99215	4.6	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE5	1
+NX_Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	400	42176	8.14	4	Membrane	NA	NA	NA	Belongs to the MS4A family.	NA	PE2	11
+NX_Q3C1V1	Uncharacterized protein C11orf91	193	20547	9.42	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	11
+NX_Q3C1V8	Brain-specific homeobox protein homolog	233	25933	6.96	0	Nucleus	NA	DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance (By similarity).	NA	Belongs to the distal-less homeobox family.	NA	PE2	11
+NX_Q3C1V9	Putative uncharacterized protein ENSP00000334305	767	84939	7.76	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q3I5F7	Putative acyl-coenzyme A thioesterase 6	207	22991	8.81	0	Cytoplasm	NA	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). It is unclear if human acyl-coenzyme A thioesterase 6/ACOT6 has an acyl-CoA thioesterase (Probable).	NA	Belongs to the C/M/P thioester hydrolase family.	Beta-oxidation of very long chain fatty acids	PE2	14
+NX_Q3KNS1	Patched domain-containing protein 3	767	86872	5.84	8	Membrane	NA	May play a role in sperm development or sperm function.	NA	Belongs to the patched family.	NA	PE1	10
+NX_Q3KNS6	Zinc finger protein 829	432	50142	8.21	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q3KNT7	Putative NOL1/NOP2/Sun domain family member 5B	163	17679	5.47	0	NA	NA	NA	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	NA	PE5	7
+NX_Q3KNT9	Transmembrane protein 95	176	19597	8.98	1	Membrane	NA	NA	NA	NA	NA	PE2	17
+NX_Q3KNV8	Polycomb group RING finger protein 3	242	28115	8.54	0	Nucleoplasm;Nucleus	NA	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).	NA	NA	NA	PE1	4
+NX_Q3KNW1	Zinc finger protein SNAI3	292	32474	9.45	0	Nucleoplasm;Nucleus	NA	Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).	NA	Belongs to the snail C2H2-type zinc-finger protein family.	NA	PE2	16
+NX_Q3KNW5	Solute carrier family 10 member 6	377	41259	8.15	9	Membrane	NA	Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.	Glycosylated.	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.	Transport of bile salts and organic acids, metal ions and amine compounds	PE1	4
+NX_Q3KP22	Membrane-anchored junction protein	176	20078	10.11	1	Nucleus inner membrane;Telomere	NA	Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.	NA	Belongs to the MAJIN family.	NA	PE1	11
+NX_Q3KP31	Zinc finger protein 791	576	66872	9.39	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q3KP44	Ankyrin repeat domain-containing protein 55	614	68414	6.72	0	Nucleoplasm;Cytosol;Nucleus speckle	NA	NA	NA	NA	NA	PE1	5
+NX_Q3KP66	Innate immunity activator protein	663	72914	9.42	0	Cytoplasm;Nucleus	Inflammatory bowel disease 29	Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).	NA	NA	NA	PE1	1
+NX_Q3KPI0	Carcinoembryonic antigen-related cell adhesion molecule 21	293	32373	5.83	1	Membrane	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	NA	PE1	19
+NX_Q3KQU3	MAP7 domain-containing protein 1	841	92820	10.12	0	Cytosol;Spindle;Cytoskeleton	NA	NA	NA	Belongs to the MAP7 family.	NA	PE1	1
+NX_Q3KQV3	Zinc finger protein 792	632	71577	8.36	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q3KQV9	UDP-N-acetylhexosamine pyrophosphorylase-like protein 1	507	57030	5.94	0	Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the UDPGP type 1 family.	Amino sugar and nucleotide sugar metabolism;Metabolic pathways	PE1	9
+NX_Q3KQZ1	Solute carrier family 25 member 35	300	32438	9.21	6	Cytoplasmic vesicle;Mitochondrion inner membrane;Mitochondrion	NA	NA	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	17
+NX_Q3KR16	Pleckstrin homology domain-containing family G member 6	790	88960	6.63	0	Cleavage furrow;Cell junction;Spindle pole;Spindle;Centrosome;Microvillus	NA	Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.	NA	NA	NA	PE1	12
+NX_Q3KR37	Protein Aster-B	738	85400	5.84	1	Endoplasmic reticulum membrane;Cell membrane;Nucleolus;Nucleoplasm;Cytoskeleton	NA	Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity).	NA	NA	NA	PE1	11
+NX_Q3KRA6	UPF0538 protein C2orf76	126	14609	6.42	0	Endoplasmic reticulum	NA	NA	NA	Belongs to the UPF0538 family.	NA	PE1	2
+NX_Q3KRA9	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6	238	26483	8.9	0	Cytoplasm;Nucleoplasm;Focal adhesion;Nucleus	NA	Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.	NA	Belongs to the alkB family.	NA	PE1	19
+NX_Q3KRB8	Rho GTPase-activating protein 11B	267	30251	9.27	0	Cytoplasmic vesicle	NA	Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503). Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not possess GTPase activator activity (PubMed:25721503).	NA	NA	Rho GTPase cycle	PE2	15
+NX_Q3L8U1	Chromodomain-helicase-DNA-binding protein 9	2897	326022	6.56	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).	Phosphorylated on serine and tyrosine residues.	Belongs to the SNF2/RAD54 helicase family.	PPARA activates gene expression;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PE1	16
+NX_Q3LFD5	Putative ubiquitin carboxyl-terminal hydrolase 41	358	41394	8.36	0	NA	NA	May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).	NA	Belongs to the peptidase C19 family.	ISG15 antiviral mechanism	PE1	22
+NX_Q3LHN0	Keratin-associated protein 25-1	102	11738	9.01	0	Cytosol;Nucleus membrane;Cell membrane	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the PMG family.	Keratinization	PE3	21
+NX_Q3LHN1	Keratin-associated protein 21-3	58	6456	7.51	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	NA	Keratinization	PE3	21
+NX_Q3LHN2	Keratin-associated protein 19-2	52	5737	8.48	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 19 family.	Keratinization	PE3	21
+NX_Q3LI54	Keratin-associated protein 19-8	63	6918	8.91	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 19 family.	Keratinization	PE2	21
+NX_Q3LI58	Keratin-associated protein 21-1	79	7937	8.15	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	NA	Keratinization	PE2	21
+NX_Q3LI59	Keratin-associated protein 21-2	83	8564	8.4	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	NA	Keratinization	PE2	21
+NX_Q3LI60	Keratin-associated protein 20-3	44	4909	7.61	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 20 family.	NA	PE3	21
+NX_Q3LI61	Keratin-associated protein 20-2	65	6961	8.63	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 20 family.	Keratinization	PE1	21
+NX_Q3LI62	Putative keratin-associated protein 20-4	44	4623	9.06	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the KRTAP type 20 family.	NA	PE2	21
+NX_Q3LI63	Keratin-associated protein 20-1	56	6202	8.24	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 20 family.	Keratinization	PE2	21
+NX_Q3LI64	Keratin-associated protein 6-1	71	7279	8.36	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 6 family.	Keratinization	PE1	21
+NX_Q3LI66	Keratin-associated protein 6-2	62	6654	6.65	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 6 family.	Keratinization	PE1	21
+NX_Q3LI67	Keratin-associated protein 6-3	103	10409	7.35	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 6 family.	Keratinization	PE3	21
+NX_Q3LI68	Keratin-associated protein 22-2	45	5218	8.39	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the KRTAP type 20 family.	NA	PE2	21
+NX_Q3LI70	Keratin-associated protein 19-6	58	6267	8.97	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 19 family.	Keratinization	PE2	21
+NX_Q3LI72	Keratin-associated protein 19-5	72	7624	8.32	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 19 family.	Keratinization	PE1	21
+NX_Q3LI73	Keratin-associated protein 19-4	84	9106	8.93	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 19 family.	Keratinization	PE2	21
+NX_Q3LI76	Keratin-associated protein 15-1	137	14979	8.15	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the PMG family.	Keratinization	PE1	21
+NX_Q3LI77	Keratin-associated protein 13-4	160	17755	9.08	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the PMG family.	Keratinization	PE1	21
+NX_Q3LI81	Keratin-associated protein 27-1	207	22345	5.45	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the PMG family.	Keratinization	PE2	21
+NX_Q3LI83	Keratin-associated protein 24-1	254	27719	8.71	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the PMG family.	Keratinization	PE1	21
+NX_Q3LIE5	Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase	342	39529	5.31	0	NA	NA	Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).	NA	Belongs to the ADPRibase-Mn family.	Purine metabolism;Glycerophospholipid metabolism;Phosphate bond hydrolysis by NUDT proteins	PE1	17
+NX_Q3LXA3	Triokinase/FMN cyclase	575	58947	7.12	0	Nucleoplasm;Cytosol	NA	Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090).	NA	Belongs to the dihydroxyacetone kinase (DAK) family.	Glycerolipid metabolism;Metabolic pathways;RIG-I-like receptor signaling pathway;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Fructose catabolism	PE1	11
+NX_Q3MHD2	Protein LSM12 homolog	195	21701	7.62	0	Cytoplasm;Cytosol	NA	NA	NA	Belongs to the LSM12 family.	NA	PE1	17
+NX_Q3MII6	TBC1 domain family member 25	688	76327	5.75	0	Cytoplasm;Autophagosome	NA	Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.	NA	NA	TBC/RABGAPs	PE1	X
+NX_Q3MIN7	Ral guanine nucleotide dissociation stimulator-like 3	710	78079	7.6	0	Nucleoplasm;Cytosol	NA	Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).	NA	NA	NA	PE1	19
+NX_Q3MIP1	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2	535	58446	9.58	1	Membrane;Centrosome	NA	NA	NA	Belongs to the ITPRIP family.	NA	PE1	16
+NX_Q3MIR4	Cell cycle control protein 50B	351	38941	8.06	2	Cell membrane	NA	Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane.	NA	Belongs to the CDC50/LEM3 family.	NA	PE1	14
+NX_Q3MIS6	Zinc finger protein 528	628	72138	9.37	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q3MIT2	Putative tRNA pseudouridine synthase Pus10	529	60244	6.1	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.	Proteolytically cleaved during TRAIL-induced cell death. Cleaved, in vitro, either by caspase-3 or caspase-8.	Belongs to the pseudouridine synthase Pus10 family.	NA	PE1	2
+NX_Q3MIV0	Keratin-associated protein 22-1	48	5275	6.48	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	NA	Keratinization	PE2	21
+NX_Q3MIW9	Mucin-like protein 3	517	56347	9.01	1	Cytoplasm;Cell membrane	NA	May modulate NF-kappaB signaling and play a role in cell growth.	NA	NA	NA	PE1	6
+NX_Q3MIX3	Uncharacterized aarF domain-containing protein kinase 5	580	65828	9.05	1	Membrane;Cytosol;Cell membrane	NA	The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).	NA	Belongs to the protein kinase superfamily. ADCK protein kinase family.	NA	PE1	8
+NX_Q3MJ13	WD repeat-containing protein 72	1102	123425	6.22	0	Cytoplasmic vesicle	Amelogenesis imperfecta, hypomaturation type, 2A3	Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane.	NA	NA	NA	PE1	15
+NX_Q3MJ16	Cytosolic phospholipase A2 epsilon	868	99190	5.46	0	Cytosol;Lysosome membrane	NA	Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position.	NA	NA	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC	PE1	15
+NX_Q3MJ40	Coiled-coil domain-containing protein 144B	725	82951	4.93	0	NA	NA	NA	NA	Belongs to the CCDC144 family.	NA	PE2	17
+NX_Q3MJ62	Zinc finger and SCAN domain-containing protein 23	389	44955	5.91	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_Q3MUY2	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y	71	8058	6.69	2	Endoplasmic reticulum membrane	Hyperphosphatasia with mental retardation syndrome 6	Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA.	NA	NA	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	4
+NX_Q3SX64	Outer dense fiber protein 3-like protein 2	289	30781	10	0	NA	NA	NA	NA	Belongs to the ODF3 family.	NA	PE1	19
+NX_Q3SXM0	DDB1- and CUL4-associated factor 4-like protein 1	396	44264	8.65	0	NA	NA	NA	NA	NA	NA	PE1	4
+NX_Q3SXM5	Inactive hydroxysteroid dehydrogenase-like protein 1	330	37002	8.93	0	Cytoplasmic vesicle;Mitochondrion;Cytoskeleton	NA	NA	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.	NA	PE1	16
+NX_Q3SXP7	Protein shisa-like-1	199	22573	8.95	1	Membrane;Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the shisa family.	NA	PE2	22
+NX_Q3SXR2	Uncharacterized protein C3orf36	165	16908	8.66	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE2	3
+NX_Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	679	74754	5.46	1	Endoplasmic reticulum membrane;Mitochondrion;Perikaryon;Nucleoplasm;Cytosol;Dendrite	Night blindness, congenital stationary, 1F	Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (By similarity). Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina (PubMed:28334377). Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (By similarity). Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (By similarity). May also have a role in cone synapse formation (By similarity). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (PubMed:22673519). Could be a regulator of the FGFRs (PubMed:22673519).	Glycosylated.	NA	NA	PE1	4
+NX_Q3SXY8	ADP-ribosylation factor-like protein 13B	428	48643	6.2	0	Cilium membrane;Cytosol;Cilium;Cytoskeleton	Joubert syndrome 8	Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidence is required to confirm these data.	Sumoylation is required for PKD2 entry into cilium.	Belongs to the small GTPase superfamily. Arf family.	ARL13B-mediated ciliary trafficking of INPP5E	PE1	3
+NX_Q3SXZ3	Zinc finger protein 718	478	55359	9.53	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	Generic Transcription Pathway	PE1	4
+NX_Q3SXZ7	Probable tubulin polyglutamylase TTLL9	439	51472	8.96	0	Nucleoplasm;Cilium basal body;Cytoskeleton	NA	Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Acts when complexed with other proteins. By mediating tubulin polyglutamylation, plays a role in the establishment of microtubule heterogeneity in sperm flagella.	NA	Belongs to the tubulin--tyrosine ligase family.	Carboxyterminal post-translational modifications of tubulin	PE2	20
+NX_Q3SY00	Testis-specific protein 10-interacting protein	556	62381	10.08	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_Q3SY05	Putative uncharacterized protein encoded by LINC00303	128	14562	9.74	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q3SY17	Solute carrier family 25 member 52	297	33721	9.69	6	Mitochondrion inner membrane	NA	NA	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE2	18
+NX_Q3SY46	Keratin-associated protein 13-3	172	19236	8.78	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the PMG family.	Keratinization	PE1	21
+NX_Q3SY52	Zinc finger protein interacting with ribonucleoprotein K	487	54786	9.1	0	Nucleus;Cytoskeleton	NA	May be a transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q3SY56	Transcription factor Sp6	376	39840	6.81	0	Nucleoplasm;Spindle;Centrosome;Nucleus	NA	Promotes cell proliferation.	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	17
+NX_Q3SY69	Mitochondrial 10-formyltetrahydrofolate dehydrogenase	923	101746	6.13	0	Mitochondrion	NA	NA	NA	In the N-terminal section; belongs to the GART family.;In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	One carbon pool by folate;Metabolism of folate and pterines	PE1	12
+NX_Q3SY77	UDP-glucuronosyltransferase 3A2	523	59547	8.51	1	Nucleoplasm;Golgi apparatus;Cytosol;Membrane	NA	UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).	NA	Belongs to the UDP-glycosyltransferase family.	Glucuronidation	PE1	5
+NX_Q3SY84	Keratin, type II cytoskeletal 71	523	57292	6.27	0	Cytoskeleton	Hypotrichosis 13	Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q3SY89	Elongin-A3 member B	546	59760	9.83	0	Nucleus	NA	SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).	NA	NA	Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes	PE2	18
+NX_Q3SYA9	Putative POM121-like protein 1	428	45448	9.17	0	NA	NA	NA	NA	Belongs to the POM121 family.	NA	PE5	22
+NX_Q3SYB3	Forkhead box protein D4-like 6	417	45787	9.76	0	Nucleus	NA	NA	NA	NA	NA	PE1	9
+NX_Q3SYC2	2-acylglycerol O-acyltransferase 2	334	38196	9.47	3	Endoplasmic reticulum membrane;Perinuclear region	NA	Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.	NA	Belongs to the diacylglycerol acyltransferase family.	Glycerolipid metabolism; triacylglycerol biosynthesis.;Fat digestion and absorption;Triglyceride biosynthesis	PE1	11
+NX_Q3SYF9	Keratin-associated protein 19-7	63	6644	8.49	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 19 family.	Keratinization	PE1	21
+NX_Q3SYG4	Protein PTHB1	887	99280	5.35	0	Cilium membrane;Cytoplasm;Centrosome;Centriolar satellite	Bardet-Biedl syndrome 9	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.	NA	NA	BBSome-mediated cargo-targeting to cilium	PE1	7
+NX_Q3T8J9	GON-4-like protein	2241	248620	4.94	0	Nucleoplasm;Nucleus	NA	Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.	NA	NA	NA	PE1	1
+NX_Q3T906	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta	1256	143622	6.74	2	Golgi apparatus;Golgi apparatus membrane	Mucolipidosis type II;Mucolipidosis type III complementation group A	Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.	The alpha- and beta-subunits are generated by a proteolytic cleavage by MBTPS1 protease at the Lys-928-Asp-929 bond.	Belongs to the stealth family.	Lysosome	PE1	12
+NX_Q3V5L5	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	792	89535	8.68	1	Golgi apparatus membrane;Nucleoplasm;Spindle;Cytoskeleton	NA	Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.	NA	Belongs to the glycosyltransferase 18 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Other types of O-glycan biosynthesis;Metabolic pathways	PE1	17
+NX_Q3V6T2	Girdin	1871	216042	5.9	0	Cell membrane;Centriole;Cilium basal body;Membrane;Lamellipodium;Cytoplasmic vesicle;Cytosol	PEHO-like syndrome	Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382).	Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration.	Belongs to the CCDC88 family.	NA	PE1	2
+NX_Q3Y452	Testis development-related protein 1	100	10472	6.81	0	Cytoplasm	NA	NA	NA	NA	NA	PE1	6
+NX_Q3YBM2	Transmembrane protein 176B	270	29056	8.81	4	Golgi apparatus;Nucleoplasm;Nucleus membrane;Cell membrane	NA	May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).	NA	Belongs to the TMEM176 family.	NA	PE1	7
+NX_Q3YBR2	Transforming growth factor beta regulator 1	411	44946	8.73	0	Nucleoplasm;Nucleus	NA	Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.	Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.	Belongs to the TBRG1 family.	NA	PE1	11
+NX_Q3YEC7	Rab-like protein 6	729	79549	5.11	0	Cytoplasm;Cytosol;Centrosome;Nucleus	NA	May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.	Is O-glycosylated, while other isoforms are not.	Belongs to the small GTPase superfamily. Rab family.	NA	PE1	9
+NX_Q3ZAQ7	Vacuolar ATPase assembly integral membrane protein VMA21	101	11354	6.56	2	Endoplasmic reticulum-Golgi intermediate compartment membrane;COPII-coated vesicle membrane;Endoplasmic reticulum membrane	Myopathy, X-linked, with excessive autophagy	Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.	NA	Belongs to the VMA21 family.	NA	PE1	X
+NX_Q3ZCM7	Tubulin beta-8 chain	444	49776	4.79	0	Spindle;Cytoskeleton	Oocyte maturation defect 2	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871).	Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;MHC class II antigen presentation;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	10
+NX_Q3ZCN5	Otogelin-like protein	2332	262091	5.01	0	Cytosol;Secreted	Deafness, autosomal recessive, 84B	NA	NA	Belongs to the otogelin family.	NA	PE1	12
+NX_Q3ZCQ2	Annexin-2 receptor	193	21682	4.88	0	Nucleoplasm;Cytosol	NA	May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.	NA	NA	NA	PE1	5
+NX_Q3ZCQ3	Membrane protein FAM174B	159	16967	8.88	1	Membrane;Cytoskeleton	NA	NA	NA	Belongs to the FAM174 family.	NA	PE1	15
+NX_Q3ZCQ8	Mitochondrial import inner membrane translocase subunit TIM50	353	39646	8.55	1	Nucleoplasm;Mitochondrion inner membrane;Nucleus speckle;Mitochondrion	3-methylglutaconic aciduria 9	May participate in the release of snRNPs and SMN from the Cajal body.;Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.	NA	Belongs to the TIM50 family.	Mitochondrial protein import	PE1	19
+NX_Q3ZCT1	Zinc finger protein 260	412	47222	9.28	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q3ZCT8	Kelch repeat and BTB domain-containing protein 12	623	71096	5.65	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_Q3ZCU0	Protein GVQW3	254	29382	9.76	0	Endoplasmic reticulum;Nucleoplasm;Centrosome	NA	NA	NA	NA	NA	PE2	11
+NX_Q3ZCV2	Lymphocyte expansion molecule	418	47583	9.85	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q3ZCW2	Galectin-related protein	172	18986	5.12	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Does not bind lactose, and may not bind carbohydrates.	NA	NA	NA	PE1	2
+NX_Q3ZCX4	Zinc finger protein 568	644	74369	8.58	0	Nucleoplasm;Nucleus	NA	Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q3ZLR7	Transcription factor SPT20 homolog-like 1	823	89431	9	0	NA	NA	NA	NA	Belongs to the SPT20 family.	NA	PE2	X
+NX_Q3ZM63	Embryonic testis differentiation protein homolog A	59	6991	10.43	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_Q400G9	Archaemetzincin-1	498	54924	5.64	0	NA	NA	Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2.	NA	Belongs to the peptidase M54 family.	NA	PE1	7
+NX_Q401N2	Zinc-activated ligand-gated ion channel	412	45816	8.45	4	Cell membrane	NA	Zinc-activated ligand-gated ion channel.	Glycosylated.	Belongs to the ligand-gated ion channel (TC 1.A.9) family.	NA	PE1	17
+NX_Q460N3	Protein mono-ADP-ribosyltransferase PARP15	678	74576	9.02	0	Mitochondrion;Nucleus	NA	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:16061477, PubMed:25043379, PubMed:25635049). Acts as a negative regulator of transcription (PubMed:16061477).	NA	NA	NA	PE1	3
+NX_Q460N5	Protein mono-ADP-ribosyltransferase PARP14	1801	202800	6.81	0	Cytoplasm;Cytosol;Nucleus	NA	ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:27796300, PubMed:18851833, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300).	Auto-ADP-ribosylated.	NA	Nicotinamide salvaging	PE1	3
+NX_Q494R0	Putative uncharacterized protein FBXL19-AS1	122	13218	9.41	0	NA	NA	NA	NA	NA	NA	PE5	16
+NX_Q494R4	Coiled-coil domain-containing protein 153	210	23858	9.34	0	Cytosol	NA	NA	NA	Belongs to the UPF0610 family.	NA	PE1	11
+NX_Q494U1	Pleckstrin homology domain-containing family N member 1	611	66409	9.06	0	Nucleus speckle;Mitochondrion;Cell membrane;Mitochondrion membrane;Cytoskeleton	NA	Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 (PubMed:29180010). Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) (PubMed:18191643). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells (PubMed:29531808) (By similarity).	Phosphorylation is essential for its mitochondrial localization and regulates its interaction with C1QBP.	NA	NA	PE1	1
+NX_Q494V2	Cilia- and flagella-associated protein 100	611	71117	6.65	0	Cilium axoneme	NA	May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.	NA	Belongs to the CFAP100 family.	NA	PE1	3
+NX_Q494W8	CHRNA7-FAM7A fusion protein	412	46218	6.11	5	Membrane	NA	NA	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family.	NA	PE1	15
+NX_Q494X3	Zinc finger protein 404	552	65425	9.32	0	Nucleus;Nucleolus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q495A1	T-cell immunoreceptor with Ig and ITIM domains	244	26319	5.5	1	Cell membrane	NA	Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.	NA	NA	NA	PE1	3
+NX_Q495B1	Ankyrin repeat and death domain-containing protein 1A	522	57550	6.22	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	15
+NX_Q495C1	Probable E3 SUMO-protein ligase RNF212	297	33365	9.04	0	Nucleus;Chromosome	NA	SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).	NA	NA	Protein modification; protein sumoylation.	PE1	4
+NX_Q495D7	Putative uncharacterized protein encoded by LINC01559	138	15996	9.11	0	NA	NA	NA	NA	NA	NA	PE2	12
+NX_Q495M3	Proton-coupled amino acid transporter 2	483	53216	8.4	11	Cytoplasm;Cell membrane	Iminoglycinuria;Hyperglycinuria	Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity).	NA	Belongs to the amino acid/polyamine transporter 2 family.	Amino acid transport across the plasma membrane;Proton-coupled neutral amino acid transporters;Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)	PE1	5
+NX_Q495M9	Usher syndrome type-1G protein	461	51489	6.48	0	Cytosol;Cell membrane;Cytoskeleton	Usher syndrome 1G	Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.	NA	NA	NA	PE1	17
+NX_Q495N2	Proton-coupled amino acid transporter 3	470	51735	5.91	11	Membrane	NA	NA	NA	Belongs to the amino acid/polyamine transporter 2 family.	NA	PE2	5
+NX_Q495T6	Membrane metallo-endopeptidase-like 1	779	89367	5.64	1	Membrane;Secreted	NA	Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).	N-glycosylated.	Belongs to the peptidase M13 family.	NA	PE1	1
+NX_Q495W5	Alpha-(1,3)-fucosyltransferase 11	492	55816	5.59	1	Golgi stack membrane;Golgi apparatus;Nucleus membrane	NA	Probable fucosyltransferase.	NA	Belongs to the glycosyltransferase 10 family.	Protein modification; protein glycosylation.;Lewis blood group biosynthesis	PE1	10
+NX_Q495X7	Tripartite motif-containing protein 60	471	55114	8.68	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE2	4
+NX_Q495Y7	Putative speedy protein E7	208	25253	8.71	0	NA	NA	NA	NA	Belongs to the Speedy/Ringo family.	NA	PE5	7
+NX_Q495Y8	Speedy protein E2	402	48300	9.78	0	NA	NA	NA	NA	Belongs to the Speedy/Ringo family.	NA	PE1	7
+NX_Q495Z4	Putative uncharacterized protein ASB16-AS1	193	20099	11.93	0	NA	NA	NA	NA	NA	NA	PE5	17
+NX_Q496A3	Spermatogenesis-associated serine-rich protein 1	300	33705	7.08	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	6
+NX_Q496F6	CMRF35-like molecule 2	205	22918	8.22	1	Cell membrane	NA	Probably acts as an activating receptor.	N-glycosylated.	Belongs to the CD300 family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 interactions	PE1	17
+NX_Q496H8	Neuritin-like protein	165	17786	8.35	0	Cell membrane	NA	NA	NA	Belongs to the neuritin family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	16
+NX_Q496J9	Synaptic vesicle glycoprotein 2C	727	82342	4.92	12	Nucleoplasm;Synaptic vesicle membrane;Cytoplasmic vesicle	NA	(Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:27313224). Recognition by BoNT/A relies on both protein-protein and protein-N-glycosylation; glycosylation of Asn-559 increases its affinity for BoNT/A (PubMed:27313224). Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed:29649119).;(Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); note that type D does not usually infect humans.;Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.	N-glycosylated. Upon expression in a kidney cell line the most abundant glycan on Asn-534 is GlcNAc(3)Hex(5), while on Asn-559 and Asn-565 the most abundant glycan is GlcNAc2Fuc1Man3GlcNAc3Gal3. Both Asn-559 and Asn-565 have a high degree of glycan heterogeneity (PubMed:27313224).	Belongs to the major facilitator superfamily.	ECM-receptor interaction;Toxicity of botulinum toxin type D (BoNT/D);Toxicity of botulinum toxin type F (BoNT/F);Toxicity of botulinum toxin type A (BoNT/A)	PE1	5
+NX_Q496M5	Inactive serine/threonine-protein kinase PLK5	336	36329	5.99	0	Cytoplasm;Nucleolus	NA	Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.	NA	PE1	19
+NX_Q496Y0	LON peptidase N-terminal domain and RING finger protein 3	759	84490	7	0	Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	X
+NX_Q499Y3	Putative uncharacterized protein C10orf88-like	187	20452	7.62	0	NA	NA	NA	NA	NA	NA	PE1	10
+NX_Q499Z3	Schlafen-like protein 1	407	45603	5.61	0	Cytosol	NA	NA	NA	Belongs to the Schlafen family. Subgroup I subfamily.	NA	PE1	1
+NX_Q499Z4	Zinc finger protein 672	452	50224	10.01	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_Q49A17	Polypeptide N-acetylgalactosaminyltransferase-like 6	601	69788	7.11	1	Golgi apparatus membrane	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE2	4
+NX_Q49A26	Putative oxidoreductase GLYR1	553	60547	9.26	0	Nucleoplasm;Cytosol;Nucleus;Chromosome	NA	Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984). Facilitates Pol II transcription through nucleosomes (PubMed:29759984). Binds DNA (in vitro) (PubMed:29759984). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Promotes KDM1B demethylase activity (PubMed:23260659). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). Putative oxidoreductase (PubMed:23260659).	NA	Belongs to the HIBADH-related family. NP60 subfamily.	NA	PE1	16
+NX_Q49A33	Putative zinc finger protein 876	203	23384	9.13	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE5	4
+NX_Q49A88	Coiled-coil domain-containing protein 14	953	106302	8.65	0	Centriolar satellite;Centrosome	NA	Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.	NA	NA	NA	PE1	3
+NX_Q49A92	Uncharacterized protein C8orf34	538	59434	5.76	0	Golgi apparatus;Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	8
+NX_Q49AA0	Zinc finger protein 69 homolog	526	61181	8.78	0	Nucleoplasm;Nucleus	NA	Putative transcription factor that appears to regulate lipid metabolism.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q49AG3	Zinc finger BED domain-containing protein 5	693	78911	8.57	0	Golgi apparatus;Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	11
+NX_Q49AH0	Cerebral dopamine neurotrophic factor	187	20964	7.5	0	Secreted	NA	Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).	NA	Belongs to the ARMET family.	NA	PE1	10
+NX_Q49AJ0	Protein FAM135B	1406	155770	5.53	0	Nucleoplasm;Nucleus membrane	NA	NA	NA	Belongs to the FAM135 family.	NA	PE1	8
+NX_Q49AM1	Transcription termination factor 2, mitochondrial	385	44414	9.15	0	Mitochondrion;Mitochondrion nucleoid	NA	Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species.	NA	Belongs to the mTERF family.	NA	PE1	12
+NX_Q49AM3	Tetratricopeptide repeat protein 31	519	57105	8.52	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	2
+NX_Q49AN0	Cryptochrome-2	593	66947	8.66	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of NAMPT (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Represses the transcriptional activity of NR1I2 (By similarity).	Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2. Phosphorylated in a circadian manner at Ser-554 and Ser-558 in the suprachiasmatic nucleus (SCN) and liver. Phosphorylation at Ser-558 by DYRK1A promotes subsequent phosphorylation at Ser-554 by GSK3-beta: the two-step phosphorylation at the neighboring Ser residues leads to its proteasomal degradation.;Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complexes, regulating the balance between degradation and stabilization. The SCF(FBXL3) complex is mainly nuclear and mediates ubiquitination and subsequent degradation of CRY2. In contrast, cytoplasmic SCF(FBXL21) complex-mediated ubiquitination leads to stabilize CRY2 and counteract the activity of the SCF(FBXL3) complex. The SCF(FBXL3) and SCF(FBXL21) complexes probably mediate ubiquitination at different Lys residues. The SCF(FBXL3) complex recognizes and binds CRY2 phosphorylated at Ser-554 and Ser-558. Ubiquitination may be inhibited by PER2. Deubiquitinated by USP7 (By similarity).	Belongs to the DNA photolyase class-1 family.	Circadian rhythm - mammal;Circadian Clock	PE1	11
+NX_Q49AR2	UPF0489 protein C5orf22	442	49967	4.65	0	Nucleus membrane	NA	NA	NA	Belongs to the UPF0489 family.	NA	PE1	5
+NX_Q49AS3	Putative protein LRRC37A5P	106	12596	10.02	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_Q49B96	Cytochrome c oxidase assembly protein COX19	90	10394	8.95	0	Cytosol;Mitochondrion intermembrane space;Mitochondrion	NA	Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis (PubMed:23345593). May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity).	NA	Belongs to the COX19 family.	Mitochondrial protein import	PE1	7
+NX_Q49MG5	Microtubule-associated protein 9	647	74234	7.59	0	Cytoplasm;Spindle;Cytoskeleton	NA	Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.	NA	NA	NA	PE1	4
+NX_Q49MI3	Ceramide kinase-like protein	558	62622	8.57	0	trans-Golgi network;Cytoplasm;Nucleolus;Endoplasmic reticulum;Nucleoplasm;Cytosol	Retinitis pigmentosa 26	Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions.	Phosphorylated on serine residues.	NA	NA	PE1	2
+NX_Q49SQ1	Probable G-protein coupled receptor 33	333	38232	9.57	7	Cell membrane	NA	Orphan receptor; could be a chemoattractant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	14
+NX_Q4AC94	C2 domain-containing protein 3	2353	260389	6.7	0	Nucleoplasm;Centriolar satellite;Cilium basal body;Centriole	Orofaciodigital syndrome 14	Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3.	NA	NA	Anchoring of the basal body to the plasma membrane	PE1	11
+NX_Q4AC99	Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2	568	65249	6.05	0	NA	NA	NA	NA	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	NA	PE1	11
+NX_Q4ADV7	RAB6A-GEF complex partner protein 1	1423	159301	5.95	1	Membrane;Cytosol	NA	The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.	NA	Belongs to the RIC1 family.	Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network;RAB GEFs exchange GTP for GDP on RABs	PE1	9
+NX_Q4AE62	Glycosyltransferase-like domain-containing protein 1	458	52597	6.83	0	Cytosol	NA	NA	NA	Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.	NA	PE1	2
+NX_Q4FZB7	Histone-lysine N-methyltransferase KMT5B	885	99188	8.98	0	Nucleoplasm;Nucleus;Chromosome	Mental retardation, autosomal dominant 51	Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.	Lysine degradation;PKMTs methylate histone lysines	PE1	11
+NX_Q4G0A6	Probable ubiquitin carboxyl-terminal hydrolase MINDY-4	757	84372	6.47	0	Cytoplasmic vesicle;Cytosol	NA	Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.	NA	Belongs to the MINDY deubiquitinase family. FAM188 subfamily.	NA	PE1	7
+NX_Q4G0F5	Vacuolar protein sorting-associated protein 26B	336	39155	6.85	0	Membrane;Cytoplasm;Early endosome;Late endosome	NA	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).	NA	Belongs to the VPS26 family.	NA	PE1	11
+NX_Q4G0G2	Putative uncharacterized protein H1FX-AS1	97	11005	6.8	0	NA	NA	NA	NA	NA	NA	PE5	3
+NX_Q4G0G5	Secretoglobin family 2B member 2	96	10563	4.57	0	Secreted	NA	NA	NA	Belongs to the secretoglobin family.	NA	PE2	19
+NX_Q4G0I0	Protein CCSMST1	132	15004	6.51	1	Membrane	NA	NA	NA	Belongs to the CCSMST1 family.	NA	PE1	16
+NX_Q4G0J3	La-related protein 7	582	66899	9.57	0	Nucleoplasm;Cytosol	Alazami syndrome	Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.	NA	NA	NA	PE1	4
+NX_Q4G0M1	Erythroferrone	354	37279	9.88	0	Secreted	NA	Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake.	N-glycosylated.	Belongs to the adipolin/erythroferrone family.	NA	PE1	2
+NX_Q4G0N0	Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase	100	11568	5.61	1	Golgi stack membrane	NA	NA	NA	Belongs to the glycosyltransferase 6 family.	NA	PE1	9
+NX_Q4G0N4	NAD kinase 2, mitochondrial	442	49433	8.46	0	Mitochondrion	2,4-dienoyl-CoA reductase deficiency	Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.	NA	Belongs to the NAD kinase family.	Nicotinate metabolism	PE1	5
+NX_Q4G0N7	Protein FAM229B	80	8717	9.02	0	Golgi apparatus;Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the FAM229 family.	NA	PE1	6
+NX_Q4G0N8	Sodium/hydrogen exchanger 10	1177	135206	6.72	16	Flagellum membrane	NA	Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity).	NA	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Stimuli-sensing channels	PE1	3
+NX_Q4G0P3	Hydrocephalus-inducing protein homolog	5121	575892	5.73	0	Cytosol;Cilium;Cell membrane	Ciliary dyskinesia, primary, 5	Required for ciliary motility.	NA	NA	NA	PE1	16
+NX_Q4G0S4	Cytochrome P450 27C1	372	42632	9.31	0	Membrane;Cytoplasmic vesicle	NA	Catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4-didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4-didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid.	NA	Belongs to the cytochrome P450 family.	NA	PE1	2
+NX_Q4G0S7	Coiled-coil domain-containing protein 152	254	29979	9.11	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	5
+NX_Q4G0T1	Scavenger receptor cysteine-rich domain-containing protein SCART1	1027	108611	5.76	1	Membrane	NA	May play a role in the immune system, perhaps as a co-receptor on alphabeta and gammadelta T-cells.	NA	NA	NA	PE1	10
+NX_Q4G0U5	Cilia- and flagella-associated protein 221	840	96891	8.79	0	Cytoplasm;Cilium axoneme	NA	May play a role in cilium morphogenesis.	NA	Belongs to the PCDP1 family.	NA	PE1	2
+NX_Q4G0W2	Dual specificity phosphatase 28	176	18324	8.61	0	Cytosol;Nucleus speckle	NA	Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro) (PubMed:24531476, PubMed:29121083). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine (PubMed:29121083). The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site (PubMed:29121083).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	2
+NX_Q4G0X4	BTB/POZ domain-containing protein KCTD21	260	29643	6.09	0	Cytosol	NA	Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).	NA	NA	Protein modification; protein ubiquitination.	PE1	11
+NX_Q4G0X9	Coiled-coil domain-containing protein 40	1142	130113	5.21	0	Cytoplasm;Cilium;Cytoskeleton	Ciliary dyskinesia, primary, 15	Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131974). Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (PubMed:21131974).	NA	Belongs to the CCDC40 family.	NA	PE1	17
+NX_Q4G0Z9	Minichromosome maintenance domain-containing protein 2	681	76219	6.79	0	Cytoskeleton	NA	Plays an important role in meiotic recombination and associated DNA double-strand break repair.	NA	NA	NA	PE1	8
+NX_Q4G112	Heat shock factor protein 5	596	65278	6.78	0	Nucleus	NA	May act as a transcriptional factor.	NA	Belongs to the HSF family.	NA	PE1	17
+NX_Q4G148	Glucoside xylosyltransferase 1	440	50567	8.92	1	Membrane	NA	Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.	NA	Belongs to the glycosyltransferase 8 family.	Other types of O-glycan biosynthesis	PE1	12
+NX_Q4G163	F-box only protein 43	708	78402	8.4	0	NA	NA	Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).	Phosphorylated on Ser-76, Thr-234 and Ser-334 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation.;Ubiquitinated in response to calcium, which promotes proteasomal degradation.	NA	Protein modification; protein ubiquitination.;Oocyte meiosis	PE1	8
+NX_Q4G176	Malonate--CoA ligase ACSF3, mitochondrial	576	64130	8.64	0	Mitochondrion	Combined malonic and methylmalonic aciduria	Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester (PubMed:21846720, PubMed:21841779). May have some preference toward very-long-chain substrates (PubMed:17762044).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Synthesis of very long-chain fatty acyl-CoAs	PE1	16
+NX_Q4G1C9	GLIPR1-like protein 2	344	40179	4.88	1	Membrane;Golgi apparatus;Cytosol;Cytoplasmic vesicle	NA	NA	NA	Belongs to the CRISP family.	NA	PE1	12
+NX_Q4J6C6	Prolyl endopeptidase-like	727	83927	5.96	0	trans-Golgi network;Cytoplasm;Golgi apparatus;Cytosol;Nucleus;Cytoskeleton	Myasthenic syndrome, congenital, 22;Hypotonia-cystinuria syndrome	Serine peptidase whose precise substrate specificity remains unclear (PubMed:16143824, PubMed:16385448, PubMed:28726805). Does not cleave peptides after a arginine or lysine residue (PubMed:16143824). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636). May play a role in the regulation of synaptic vesicle exocytosis (PubMed:24610330).	NA	Belongs to the peptidase S9A family.	NA	PE1	2
+NX_Q4JDL3	Tyrosine-protein phosphatase non-receptor type 20	420	48423	5.54	0	Cytoplasm;Centriolar satellite;Centrosome;Nucleus	NA	Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.	Interleukin-37 signaling	PE1	10
+NX_Q4KMG0	Cell adhesion molecule-related/down-regulated by oncogenes	1287	139147	6.04	1	Cell membrane	Holoprosencephaly 11	Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).	N-glycosylated.	NA	Activation of SMO;Ligand-receptor interactions;Myogenesis	PE1	11
+NX_Q4KMG9	Transmembrane protein 52B	183	20002	5.39	1	Membrane;Focal adhesion	NA	NA	NA	NA	NA	PE1	12
+NX_Q4KMP7	TBC1 domain family member 10B	808	87199	9.27	0	Cytoplasm	NA	Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A.	NA	NA	TBC/RABGAPs	PE1	16
+NX_Q4KMQ1	Taperin	711	75556	6.82	0	Stereocilium;Cell membrane	Deafness, autosomal recessive, 79	NA	NA	Belongs to the taperin family.	NA	PE1	9
+NX_Q4KMQ2	Anoctamin-6	910	106165	7.92	10	Cytosol;Cell membrane	Scott syndrome	Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.	NA	Belongs to the anoctamin family.	Stimuli-sensing channels;Neutrophil degranulation	PE1	12
+NX_Q4KMX7	Protein FAM106A	169	18795	5.78	0	NA	NA	NA	NA	Belongs to the FAM106 family.	NA	PE2	17
+NX_Q4KMZ1	IQ domain-containing protein C	466	53032	8.22	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	1
+NX_Q4KMZ8	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1	207	23552	5.21	3	Cell membrane	NA	NA	NA	Belongs to the NKAIN family.	NA	PE2	1
+NX_Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	1693	189223	7.87	0	Membrane;Cytoplasm;Cytoplasmic vesicle	NA	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.	NA	NA	Synthesis of IP3 and IP4 in the cytosol	PE1	3
+NX_Q4L180	Filamin A-interacting protein 1-like	1135	130382	6.17	0	Membrane;Cytoplasm;Nucleus;Cell membrane	NA	Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.	NA	Belongs to the FILIP1 family.	NA	PE1	3
+NX_Q4L235	Beta-alanine-activating enzyme	1098	122597	6.9	0	NA	NA	Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA.	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	NA	PE1	4
+NX_Q4LDE5	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1	3571	390170	5.32	0	Membrane;Cytoplasm;Secreted	NA	May play a role in the cell attachment process.	O-glycosylated with core 1 or possibly core 8 glycans.	NA	NA	PE1	9
+NX_Q4LDG9	Dynein light chain 1, axonemal	190	21533	5.87	0	Nucleoplasm;Centriolar satellite;Cilium axoneme	Ciliary dyskinesia, primary, 16	Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (PubMed:21496787).	NA	Belongs to the dynein light chain LC1-type family.	Huntington's disease	PE1	14
+NX_Q4LDR2	Cortexin-3	81	8933	4.56	1	Membrane	NA	NA	NA	Belongs to the cortexin family.	NA	PE2	5
+NX_Q4LE39	AT-rich interactive domain-containing protein 4B	1312	147809	5.04	0	Nucleoplasm;Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).	NA	NA	NoRC negatively regulates rRNA expression;HDACs deacetylate histones	PE1	1
+NX_Q4LEZ3	Alanine and arginine-rich domain-containing protein	155	17575	5.81	0	Lipid droplet	NA	NA	NA	NA	NA	PE1	8
+NX_Q4QY38	Beta-defensin 134	66	7552	6.52	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	8
+NX_Q4U2R6	39S ribosomal protein L51, mitochondrial	128	15095	11.27	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL51 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	12
+NX_Q4U2R8	Solute carrier family 22 member 6	563	61816	9.05	12	Cell membrane	NA	Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.	Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane.	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Organic anion transport	PE1	11
+NX_Q4UJ75	Ankyrin repeat domain-containing protein 20A4	823	94149	8.11	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q4V321	G antigen 13	117	12957	4.17	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE2	X
+NX_Q4V326	G antigen 2E	110	12217	4.3	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE2	X
+NX_Q4V328	GRIP1-associated protein 1	841	96006	5.08	0	Recycling endosome membrane;Synapse;Early endosome membrane;Cytoplasmic vesicle;Cytosol;Axon;Dendrite	NA	Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity).;GRASP-1 C-terminal chain: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.	Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Proteolytic cleavage is required for JNK signaling activation.	NA	NA	PE1	X
+NX_Q4V339	COBW domain-containing protein 6	395	43964	4.76	0	NA	NA	NA	NA	Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.	NA	PE2	9
+NX_Q4V348	Zinc finger protein 658B	819	94331	8.9	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	9
+NX_Q4V9L6	Transmembrane protein 119	283	29203	4.5	1	Cytoplasm;Endoplasmic reticulum membrane;Cell membrane	NA	Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).	NA	NA	NA	PE1	12
+NX_Q4VC05	B-cell CLL/lymphoma 7 protein family member A	210	22810	5.01	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the BCL7 family.	NA	PE1	12
+NX_Q4VC12	Putative protein MSS51 homolog, mitochondrial	460	51289	6.49	0	Cytoplasmic vesicle;Cytosol	NA	NA	NA	NA	NA	PE1	10
+NX_Q4VC31	Coiled-coil domain-containing protein 58	144	16620	7.67	0	Mitochondrion;Nucleolus;Cytoskeleton	NA	NA	NA	Belongs to the CCDC58 family.	NA	PE1	3
+NX_Q4VC39	Putative HIG1 domain family member 2B	106	11405	8.55	2	Membrane	NA	NA	NA	NA	NA	PE5	15
+NX_Q4VC44	FLYWCH-type zinc finger-containing protein 1	716	80108	8.68	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	16
+NX_Q4VCS5	Angiomotin	1084	118085	7.27	0	Nucleoplasm;Tight junction;Cell junction	NA	Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.	Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation.	Belongs to the angiomotin family.	Signaling by Hippo	PE1	X
+NX_Q4VNC0	Probable cation-transporting ATPase 13A5	1218	137327	8.19	10	Membrane	NA	NA	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.	Ion transport by P-type ATPases	PE1	3
+NX_Q4VNC1	Probable cation-transporting ATPase 13A4	1196	133987	6.27	11	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.	Ion transport by P-type ATPases	PE1	3
+NX_Q4VX62	Putative uncharacterized protein C6orf99	202	22766	8.57	0	NA	NA	NA	NA	NA	NA	PE4	6
+NX_Q4VX76	Synaptotagmin-like protein 3	610	68560	9.41	0	Cytoplasmic vesicle;Endomembrane system;Nucleolus	NA	May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).	NA	NA	NA	PE1	6
+NX_Q4VXA5	KH homology domain-containing protein 1	237	27160	8.58	2	Membrane;Cytosol;Mitochondrion	NA	NA	NA	Belongs to the KHDC1 family.	NA	PE2	6
+NX_Q4VXF1	Putative protein FAM74A3	159	18188	9.41	1	Membrane	NA	NA	NA	Belongs to the FAM74 family.	NA	PE5	9
+NX_Q4VXU2	Polyadenylate-binding protein 1-like	614	68392	9.06	0	Cytosol;Nucleus	NA	NA	NA	Belongs to the polyadenylate-binding protein type-1 family.	RNA transport;mRNA surveillance pathway;RNA degradation	PE1	20
+NX_Q4W4Y0	Uncharacterized protein C14orf28	310	36306	6.18	0	Cytosol	NA	NA	NA	NA	NA	PE2	14
+NX_Q4W5G0	Tigger transposable element-derived protein 2	525	59623	9.12	0	Nucleus	NA	NA	NA	Belongs to the tigger transposable element derived protein family.	NA	PE1	4
+NX_Q4W5N1	Putative ATP-binding cassette sub-family A member 11	156	17479	9.43	0	NA	NA	NA	NA	Belongs to the ABC transporter superfamily. ABCA family.	NA	PE2	4
+NX_Q4W5P6	Protein TMEM155	130	14221	10.29	0	Secreted	NA	NA	NA	NA	NA	PE2	4
+NX_Q4ZG55	Protein GREB1	1949	216467	6.49	1	Membrane;Cytosol;Mitochondrion	NA	May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.	NA	Belongs to the GREB1 family.	Estrogen-dependent gene expression	PE1	2
+NX_Q4ZHG4	Fibronectin type III domain-containing protein 1	1894	205558	9.35	0	Nucleus speckle;Secreted	NA	May be an activator of G protein signaling.	NA	NA	NA	PE1	6
+NX_Q4ZIN3	Membralin	620	67889	5.14	4	Endoplasmic reticulum;Nucleus speckle;Endoplasmic reticulum membrane	NA	May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.	NA	Belongs to the membralin family.	NA	PE1	19
+NX_Q4ZJI4	Sodium/hydrogen exchanger 9B1	515	56054	8.27	13	Flagellum membrane	NA	Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility.	NA	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Stimuli-sensing channels	PE1	4
+NX_Q502W6	von Willebrand factor A domain-containing protein 3B	1294	145748	7.01	0	Nucleoplasm;Cytoplasm;Cytosol	Spinocerebellar ataxia, autosomal recessive, 22	NA	NA	NA	NA	PE1	2
+NX_Q502W7	Coiled-coil domain-containing protein 38	563	65315	8.81	0	Centrosome	NA	NA	NA	NA	NA	PE1	12
+NX_Q502X0	MORN repeat-containing protein 2	79	8939	5.4	0	Nucleoplasm;Nucleus;Acrosome	NA	Might have a role in spermatogenesis.	NA	NA	NA	PE1	2
+NX_Q504Q3	PAN2-PAN3 deadenylation complex catalytic subunit PAN2	1202	135368	5.64	0	Cytoplasm;P-body;Nucleus	NA	Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.	NA	Belongs to the peptidase C19 family. PAN2 subfamily.	RNA degradation;Deadenylation of mRNA	PE1	12
+NX_Q504T8	Midnolin	468	49213	9.67	0	Nucleoplasm;Nucleolus;Cytosol;Nucleus	NA	Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.	NA	NA	NA	PE1	19
+NX_Q504U0	Renal cancer differentiation gene 1 protein	113	11899	4.24	0	Cytoplasm;Nucleoplasm	NA	NA	NA	NA	NA	PE1	4
+NX_Q504Y0	Zinc transporter ZIP12	691	76666	5.85	8	Membrane	NA	Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia.	NA	Belongs to the ZIP transporter (TC 2.A.5) family.	NA	PE1	10
+NX_Q504Y2	Extracellular tyrosine-protein kinase PKDCC	493	54132	8.76	0	Golgi apparatus;Secreted	NA	Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).	N-glycosylated.;Phosphorylated on tyrosines; probably via autophosphorylation.	Belongs to the protein kinase superfamily.	NA	PE1	2
+NX_Q504Y3	Zinc finger CW-type PWWP domain protein 2	356	41376	5.56	0	Nucleus speckle	NA	NA	NA	NA	NA	PE1	3
+NX_Q50LG9	Leucine-rich repeat-containing protein 24	513	55257	9.24	1	Membrane;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	8
+NX_Q52LA3	Protein lin-52 homolog	116	13001	4.89	0	Nucleus speckle	NA	NA	NA	Belongs to the lin-52 family.	G0 and Early G1;G1/S-Specific Transcription;Polo-like kinase mediated events;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	PE1	14
+NX_Q52LC2	V-type proton ATPase subunit S1-like protein	224	25310	9.6	1	Membrane;Cytosol;Nucleolus	NA	NA	NA	Belongs to the vacuolar ATPase subunit S1 family.	NA	PE2	5
+NX_Q52LD8	Raftlin-2	501	55922	5.56	0	Cell membrane	NA	Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling.	NA	Belongs to the raftlin family.	NA	PE1	2
+NX_Q52LG2	Keratin-associated protein 13-2	175	18727	8.72	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the PMG family.	Keratinization	PE1	21
+NX_Q52LJ0	Protein FAM98B	433	45547	8.88	0	Cytoplasmic vesicle;Nucleoplasm;Cytoplasm;Nucleus	NA	Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). Promotes colorectal cancer cell malignancy (PubMed:28040436).	NA	Belongs to the FAM98 family.	tRNA processing in the nucleus	PE1	15
+NX_Q52LR7	Enhancer of polycomb homolog 2	807	91095	8.95	0	Nucleus speckle;Nucleus	NA	May play a role in transcription or DNA repair.	NA	Belongs to the enhancer of polycomb family.	NA	PE1	2
+NX_Q52LW3	Rho GTPase-activating protein 29	1261	142064	6.32	0	Nucleoplasm;Cytosol;Centrosome;Cell membrane	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.	NA	NA	Rho GTPase cycle	PE1	1
+NX_Q52M58	Putative uncharacterized protein C14orf177	125	13861	9.23	0	NA	NA	NA	NA	NA	NA	PE2	14
+NX_Q52M75	Putative uncharacterized protein encoded by LINC01554	96	10857	9.96	0	NA	NA	NA	NA	NA	NA	PE4	5
+NX_Q52M93	Zinc finger protein 585B	769	88066	9.26	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q52MB2	Coiled-coil domain-containing protein 184	194	20484	4.04	0	Cytoplasm;Cytosol;Mitochondrion	NA	NA	NA	NA	NA	PE1	12
+NX_Q52WX2	Serine/threonine-protein kinase SBK1	424	46252	9.28	0	Cytoplasm	NA	May be involved in signal-transduction pathways related to the control of brain development.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	16
+NX_Q537H7	Spermatogenesis-associated protein 45	98	11356	10.08	0	NA	NA	NA	NA	Belongs to the SPATA45 family.	NA	PE1	1
+NX_Q538Z0	Leucine zipper protein 6	58	6437	9.7	0	Lipid droplet	NA	NA	NA	NA	NA	PE1	7
+NX_Q53EL6	Programmed cell death protein 4	469	51735	5.07	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).	Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.;Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.	Belongs to the PDCD4 family.	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	10
+NX_Q53EL9	Seizure protein 6 homolog	994	107425	5.16	1	Cell membrane	NA	May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity).	Glycosylated.	Belongs to the SEZ6 family.	NA	PE1	17
+NX_Q53EP0	Fibronectin type III domain-containing protein 3B	1204	132888	5.64	1	Membrane;Endoplasmic reticulum	NA	May be a positive regulator of adipogenesis.	NA	Belongs to the FNDC3 family.	NA	PE1	3
+NX_Q53EQ6	Tigger transposable element-derived protein 5	642	69222	8.68	0	Nucleus	NA	NA	NA	Belongs to the tigger transposable element derived protein family.	NA	PE1	8
+NX_Q53ET0	CREB-regulated transcription coactivator 2	693	73302	6.6	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).	Asymmetric dimethylation of arginine resisues by PRMT6 enhances the association of CRTC2 with CREB on the promoters of gluconeogenic genes.;Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity (PubMed:15589160, PubMed:17210223). CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site (PubMed:17210223). This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs (SIK1 and SIK2) by LKB1 (PubMed:15454081, PubMed:16817901). Following adenylyl cyclase activation, dephosphorylated at Ser-171 by PPP3CA/calcineurin A resulting in CRTC2 dissociation from 14-3-3 proteins and PPP3CA (By similarity). Both insulin and AMPK increase this phosphorylation of CRTC2 while glucagon suppresses it (PubMed:15454081). Phosphorylation at Ser-274 by MARK2 is induced under low glucose conditions and dephosphorylated in response to glucose influx (PubMed:18626018). Phosphorylation at Ser-274 promotes interaction with 14-3-3 proteins and translocation to the cytoplasm (PubMed:18626018).	Belongs to the TORC family.	HTLV-I infection;Circadian Clock;Transcriptional activation of mitochondrial biogenesis	PE1	1
+NX_Q53EU6	Glycerol-3-phosphate acyltransferase 3	434	48705	9.05	3	Cytosol;Endoplasmic reticulum membrane;Cell membrane	NA	Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427).	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Glycerolipid metabolism; triacylglycerol biosynthesis.;Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.;Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PA	PE1	4
+NX_Q53EV4	Leucine-rich repeat-containing protein 23	343	39761	4.57	0	Nucleolus	NA	NA	NA	NA	NA	PE1	12
+NX_Q53EZ4	Centrosomal protein of 55 kDa	464	54178	6.55	0	Cytoplasm;Cleavage furrow;Centriole;Cell membrane;Centriolar satellite;Centrosome;Midbody;Midbody ring	Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly	Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986).	There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis, prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at the final stages of cell division to complete cytokinesis successfully.	NA	NA	PE1	10
+NX_Q53F19	Nuclear cap-binding protein subunit 3	620	70593	5.55	0	Cytoplasm;Nucleus speckle;Nucleus	NA	Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858).	NA	Belongs to the NCBP3 family.	NA	PE1	17
+NX_Q53F39	Metallophosphoesterase 1	396	45141	6.71	2	Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment membrane;Nucleoplasm;cis-Golgi network membrane	NA	Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.	NA	Belongs to the metallophosphoesterase superfamily. MPPE1 family.	NA	PE1	18
+NX_Q53FA7	Quinone oxidoreductase PIG3	332	35536	6.66	0	Cytoplasmic vesicle	NA	May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.	p53 signaling pathway;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	PE1	2
+NX_Q53FD0	Zinc finger C2HC domain-containing protein 1C	456	51658	9.58	0	Cytoplasm;Nucleus speckle;Mitochondrion	NA	NA	NA	Belongs to the ZC2HC1 family.	NA	PE1	14
+NX_Q53FE4	Uncharacterized protein C4orf17	359	39644	9.4	0	NA	NA	NA	NA	NA	NA	PE1	4
+NX_Q53FP2	Transmembrane protein 35A	167	18440	10.09	4	Cytoplasmic vesicle;Cytosol;Peroxisome membrane;Focal adhesion	NA	A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.	NA	Belongs to the DoxX family.	NA	PE1	X
+NX_Q53FT3	Protein Hikeshi	197	21628	5.27	0	Cytoplasm;Nucleus speckle;Nucleoplasm;Cytosol;Nucleus	Leukodystrophy, hypomyelinating, 13	Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.	NA	Belongs to the OPI10 family.	Regulation of HSF1-mediated heat shock response	PE1	11
+NX_Q53FV1	ORM1-like protein 2	153	17363	9.64	2	Endoplasmic reticulum membrane	NA	Negative regulator of sphingolipid synthesis.	NA	Belongs to the ORM family.	Sphingolipid de novo biosynthesis	PE1	12
+NX_Q53FZ2	Acyl-coenzyme A synthetase ACSM3, mitochondrial	586	66153	9.16	0	Mitochondrion matrix	NA	Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Butanoate metabolism;Metabolic pathways;Beta oxidation of butanoyl-CoA to acetyl-CoA	PE1	16
+NX_Q53G44	Interferon-induced protein 44-like	452	51322	6.33	0	Cytoplasm;Nucleoplasm	NA	Exhibits a low antiviral activity against hepatitis C virus.	NA	Belongs to the IFI44 family.	NA	PE1	1
+NX_Q53G59	Kelch-like protein 12	568	63277	5.26	0	Cytoplasmic vesicle;Centriolar satellite;COPII-coated vesicle	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export (PubMed:27716508). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (PubMed:16547521). The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins (PubMed:18303015, PubMed:20100572, PubMed:27716508).	Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteaseome: ubiquitination by the SCF(FBXL17) complex takes place when aberrant BTB domain dimers are formed.	NA	Protein modification; protein ubiquitination.;Degradation of DVL	PE1	1
+NX_Q53GA4	Pleckstrin homology-like domain family A member 2	152	17092	9.3	0	Membrane;Cytoplasm;Nucleolus	NA	Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).	NA	Belongs to the PHLDA2 family.	NA	PE1	11
+NX_Q53GD3	Choline transporter-like protein 4	710	79254	8.91	10	Membrane;Apical cell membrane	Deafness, autosomal dominant, 72	Has also thiamine pyrophosphate transporter activity.;Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity) (PubMed:23651124, PubMed:28013291). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed:24379411).	N-glycosylated; N-glycosylation of Asn-69, Asn-155 and Asn-393 is required for a proper thiamine pyrophosphate uptake.	Belongs to the CTL (choline transporter-like) family.	Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds	PE1	6
+NX_Q53GG5	PDZ and LIM domain protein 3	364	39232	6.42	0	Cytosol;Z line	NA	May play a role in the organization of actin filament arrays within muscle cells.	NA	NA	NA	PE1	4
+NX_Q53GI3	Zinc finger protein 394	561	64256	8.14	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q53GL0	Pleckstrin homology domain-containing family O member 1	409	46237	8.93	0	Cytoplasm;Mitochondrion;Nucleus;Cell membrane	NA	Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.	C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage.	NA	NA	PE1	1
+NX_Q53GL7	Protein mono-ADP-ribosyltransferase PARP10	1025	109998	4.9	0	Golgi apparatus;Cytoplasm;Cytosol;Nucleolus	NA	ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737).	Auto-mono-ADP-ribosylated on glutamate and lysine residues.;Stimulated through its phosphorylation by CDK2 (PubMed:16455663). Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions (PubMed:16455663). Phosphorylation is suppressed in growth-arrested cells (PubMed:16455663).	NA	Nicotinamide salvaging	PE1	8
+NX_Q53GQ0	Very-long-chain 3-oxoacyl-CoA reductase	312	34324	9.34	3	Endoplasmic reticulum membrane	NA	Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.	Lipid metabolism; fatty acid biosynthesis.;Steroid biosynthesis; estrogen biosynthesis.;Fatty acid elongation;Steroid hormone biosynthesis;Biosynthesis of unsaturated fatty acids;Metabolic pathways;Synthesis of very long-chain fatty acyl-CoAs;Androgen biosynthesis	PE1	11
+NX_Q53GS7	Nucleoporin GLE1	698	79836	7.06	0	Cytoplasm;Nuclear pore complex;Nucleolus;Nucleus membrane;Nucleus	Congenital arthrogryposis with anterior horn cell disease;Lethal congenital contracture syndrome 1	Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).	NA	Belongs to the GLE1 family.	Transport of Mature mRNA derived from an Intron-Containing Transcript	PE1	9
+NX_Q53GS9	U4/U6.U5 tri-snRNP-associated protein 2	565	65381	9.02	0	Nucleoplasm;Nucleus	NA	Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity (PubMed:18728397).	NA	Belongs to the peptidase C19 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	2
+NX_Q53GT1	Kelch-like protein 22	634	71667	5.28	0	Golgi apparatus;Centrosome;Lysosome;Cytosol;Spindle;Nucleus;Cytoskeleton	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (PubMed:19995937, PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy (PubMed:29769719).	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	22
+NX_Q53H12	Acylglycerol kinase, mitochondrial	422	47137	8.3	0	Cytoplasmic vesicle;Mitochondrion intermembrane space;Mitochondrion inner membrane;Mitochondrion	Mitochondrial DNA depletion syndrome 10;Cataract 38	Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762). Does not phosphorylate sphingosine (PubMed:15939762). Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed:28712724, PubMed:28712726). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed:28712724). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed:15939762).	NA	Belongs to the AGK family.	Lipid metabolism; glycerolipid metabolism.;Glycerolipid metabolism;Metabolic pathways;Glycerophospholipid biosynthesis;Signaling by BRAF and RAF fusions	PE1	7
+NX_Q53H47	Histone-lysine N-methyltransferase SETMAR	684	78034	6.75	0	Nucleus;Nucleolus;Chromosome	NA	Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750).	Methylated. Methylation regulates activity in DNA decatenation.;Phosphorylated at Ser-508 by CHEK1 and dephosphorylated by protein phosphatase 2A/PP2A. Phosphorylation at Ser-508 is enhanced by DNA damage and promotes recruitment to damaged DNA. It stimulates DNA repair and impairs replication fork restart.	In the N-terminal section; belongs to the class V-like SAM-binding methyltransferase superfamily.;In the C-terminal section; belongs to the mariner transposase family.	Lysine degradation	PE1	3
+NX_Q53H54	tRNA wybutosine-synthesizing protein 2 homolog	448	50236	8.21	0	Nucleoplasm;Mitochondrion	NA	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.	tRNA modification; wybutosine-tRNA(Phe) biosynthesis.;Synthesis of wybutosine at G37 of tRNA(Phe)	PE1	8
+NX_Q53H64	Putative ANKRD40 C-terminal-like protein	114	13397	7.65	0	NA	NA	NA	NA	NA	NA	PE2	17
+NX_Q53H76	Phospholipase A1 member A	456	49715	7.11	0	Nucleoplasm;Cytosol;Nucleus speckle;Secreted	NA	Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI).;Hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Acyl chain remodelling of PS	PE1	3
+NX_Q53H80	Akirin-2	203	22496	8.96	0	Nucleoplasm;Nucleus	NA	Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).	NA	Belongs to the akirin family.	NA	PE1	6
+NX_Q53H82	Endoribonuclease LACTB2	288	32806	6.32	0	Golgi apparatus;Nucleoplasm;Mitochondrion matrix;Cytosol	NA	Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.	NA	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.	NA	PE1	8
+NX_Q53H96	Pyrroline-5-carboxylate reductase 3	274	28663	7.66	0	Nucleoplasm;Cytoplasm;Cytosol	NA	Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.	NA	Belongs to the pyrroline-5-carboxylate reductase family.	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.;Arginine and proline metabolism;Metabolic pathways;Glutamate and glutamine metabolism	PE1	8
+NX_Q53HC0	Coiled-coil domain-containing protein 92	331	36961	8.96	0	Nucleoplasm;Centrosome;Centriole	NA	NA	NA	NA	NA	PE1	12
+NX_Q53HC5	Kelch-like protein 26	615	68139	6.04	0	NA	NA	NA	NA	NA	NA	PE1	19
+NX_Q53HC9	EARP and GARP complex-interacting protein 1	387	43603	4.87	0	trans-Golgi network;Nucleoplasm;Nucleolus;Cytoskeleton	NA	Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex.	NA	Belongs to the WD repeat EIPR1 family.	NA	PE1	2
+NX_Q53HI1	Protein unc-50 homolog	259	30373	9.5	5	Endoplasmic reticulum;Golgi apparatus membrane;Nucleus inner membrane	NA	May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity).	NA	Belongs to the unc-50 family.	NA	PE1	2
+NX_Q53HL2	Borealin	280	31323	9.88	0	Cytoplasm;Nucleolus;Nucleoplasm;Centromere;Spindle;Cytoskeleton	NA	Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.	Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-230. Phosphorylation (probably by CDK1) promotes targeting of the CPC to centromeric DNA.;Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3.	Belongs to the borealin family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;SUMOylation of DNA replication proteins	PE1	1
+NX_Q53HV7	Single-strand selective monofunctional uracil DNA glycosylase	270	29862	6.18	0	Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.	NA	Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.	Base excision repair;Displacement of DNA glycosylase by APEX1;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine	PE1	12
+NX_Q53LP3	Ankyrin repeat domain-containing protein SOWAHC	525	55672	6.55	0	Cytosol	NA	NA	NA	Belongs to the SOWAH family.	NA	PE1	2
+NX_Q53QV2	Protein LBH	105	12217	4.33	0	Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.	NA	Belongs to the LBH family.	NA	PE1	2
+NX_Q53QW1	Testis-expressed protein 44	395	41589	4.97	0	Cytoplasm	NA	NA	NA	NA	NA	PE1	2
+NX_Q53QZ3	Rho GTPase-activating protein 15	475	54544	9.42	0	Cytoplasm;Golgi apparatus;Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.	NA	NA	Rho GTPase cycle	PE1	2
+NX_Q53R12	Transmembrane 4 L6 family member 20	229	25075	6.4	4	Membrane;Endoplasmic reticulum membrane;Focal adhesion;Cell membrane	Specific language impairment 5	Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).	Cleaved by signal peptidase at Ser-14 but the peptide does not act as a signal peptide. Cleavage is inhibited by ceramide which inverts the orientation of TM4SF20 in membranes exposing the N-terminus to the cytosol and not to the endoplasmic reticulum lumen.;Glycosylated at Asn-132, Asn-148 and Asn-163 in presence of ceramide which inverts the orientation of TM4SF20 in membranes exposing these residues to the endoplasmic reticulum lumen.	Belongs to the L6 tetraspanin family.	NA	PE1	2
+NX_Q53R41	FAST kinase domain-containing protein 1, mitochondrial	847	97411	7.8	0	Nucleoplasm;Mitochondrion	NA	Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity.	NA	Belongs to the FAST kinase family.	NA	PE1	2
+NX_Q53RD9	Fibulin-7	439	47376	7.88	0	Cell junction;Extracellular matrix;Cell membrane	NA	An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation.	N-glycosylated.	Belongs to the fibulin family.	NA	PE1	2
+NX_Q53RE8	Ankyrin repeat domain-containing protein 39	183	19651	6.39	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the ANKRD39 family.	NA	PE1	2
+NX_Q53RT3	Retroviral-like aspartic protease 1	343	36991	5.28	1	Membrane	NA	NA	Undergoes autocleavage which is necessary for activation of the protein.	NA	NA	PE1	2
+NX_Q53RY4	Keratinocyte-associated protein 3	240	25627	8.12	4	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the TMEM54 family.	NA	PE1	2
+NX_Q53S08	Ras-related protein Rab-6D	254	28242	6.41	0	NA	NA	NA	NA	Belongs to the small GTPase superfamily. Rab family.	NA	PE2	2
+NX_Q53S33	BolA-like protein 3	107	12114	9.66	0	Cytosol;Mitochondrion;Nucleus	Multiple mitochondrial dysfunctions syndrome 2 with hyperglycinemia	Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1 (PubMed:27532772).	NA	Belongs to the BolA/IbaG family.	NA	PE1	2
+NX_Q53S58	Transmembrane protein 177	311	33760	9.66	3	Nucleoplasm;Mitochondrion inner membrane;Nucleolus	NA	Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.	NA	Belongs to the TMEM177 family.	NA	PE1	2
+NX_Q53S99	Folate transporter-like protein C2orf83	150	16373	6.18	0	Endoplasmic reticulum	NA	NA	NA	Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.	NA	PE2	2
+NX_Q53SF7	Cordon-bleu protein-like 1	1128	123868	6.14	0	Cell junction	NA	NA	NA	NA	NA	PE1	2
+NX_Q53SZ7	Proline-rich protein 30	412	44690	10.39	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q53T59	HCLS1-binding protein 3	392	42780	4.89	0	Cytosol;Nucleolus	NA	May be a modulator of IL-2 signaling.	NA	NA	NA	PE1	2
+NX_Q53T94	TATA box-binding protein-associated factor RNA polymerase I subunit B	588	68832	8.27	0	Nucleoplasm;Nucleolus	NA	Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.	NA	Belongs to the RRN7/TAF1B family.	NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;SIRT1 negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression	PE1	2
+NX_Q53TN4	Cytochrome b reductase 1	286	31641	8.89	6	Membrane;Golgi apparatus;Cytosol	NA	Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.	NA	NA	Mineral absorption;Iron uptake and transport	PE1	2
+NX_Q53TQ3	INO80 complex subunit D	1027	113202	7.83	0	Nucleus	NA	Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	NA	Belongs to the INO80D family.	DNA Damage Recognition in GG-NER;UCH proteinases	PE1	2
+NX_Q53TS8	C2 calcium-dependent domain-containing protein 6	623	71159	6.55	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q562E7	WD repeat-containing protein 81	1941	211697	5.37	0	Autophagosome membrane;Mitochondrion;Lysosome membrane;Nucleoplasm;Early endosome membrane;Cytosol;Late endosome membrane	Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 2;Hydrocephalus, congenital, 3, with brain anomalies	Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity).	NA	Belongs to the WD repeat WDR81 family.	NA	PE1	17
+NX_Q562F6	Shugoshin 2	1265	144739	8.09	0	Nucleoplasm;Nucleus;Centromere;Kinetochore	NA	Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.	NA	Belongs to the shugoshin family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	2
+NX_Q562R1	Beta-actin-like protein 2	376	42003	5.39	0	Cytoskeleton	NA	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).;Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity).	Belongs to the actin family.	NA	PE1	5
+NX_Q567U6	Coiled-coil domain-containing protein 93	631	73198	8.24	0	Cytoplasmic vesicle;Early endosome;Cell membrane	NA	(Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.;Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:28892079, PubMed:25355947). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947).	NA	Belongs to the CCDC93 family.	NA	PE1	2
+NX_Q567V2	Mpv17-like protein 2	206	23180	9.41	3	Membrane;Mitochondrion inner membrane	NA	Required for the assembly and stability of the mitochondrial ribosome (PubMed:24948607). Is a positive regulator of mitochondrial protein synthesis (PubMed:24948607).	NA	Belongs to the peroxisomal membrane protein PXMP2/4 family.	NA	PE1	19
+NX_Q569G3	Uncharacterized protein C5orf47	176	19206	10.49	0	NA	NA	NA	NA	NA	NA	PE1	5
+NX_Q569H4	Protein Largen	304	32812	9.09	0	Nucleoplasm;Cytosol;Midbody	NA	Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration.	NA	NA	NA	PE1	5
+NX_Q569K4	Zinc finger protein 385B	471	50407	9.92	0	Nucleolus;Nucleus	NA	May play a role in p53/TP53-mediated apoptosis.	NA	NA	NA	PE1	2
+NX_Q569K6	Coiled-coil domain-containing protein 157	752	83941	6.76	0	NA	NA	NA	NA	NA	NA	PE1	22
+NX_Q56A73	Spindlin-4	249	28660	7.13	0	Cytosol;Nucleolus	NA	Exhibits H3K4me3-binding activity.	NA	Belongs to the SPIN/STSY family.	NA	PE1	X
+NX_Q56NI9	N-acetyltransferase ESCO2	601	68307	9.46	0	Golgi apparatus;Cell junction;Chromosome;Nucleoplasm;Nucleus	Roberts syndrome;SC phocomelia syndrome	Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234).	NA	Belongs to the acetyltransferase family. ECO subfamily.	Establishment of Sister Chromatid Cohesion	PE1	8
+NX_Q56P03	E2F-associated phosphoprotein	285	32762	5	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol;Nucleus	NA	May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.	NA	NA	NA	PE1	14
+NX_Q56P42	Pyrin domain-containing protein 2	97	10795	5.21	0	Cytoplasm;Nucleus	NA	May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17339483, PubMed:17178784). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464).	NA	NA	NA	PE1	3
+NX_Q56UN5	Mitogen-activated protein kinase kinase kinase 19	1328	150537	6.61	0	Cytosol	NA	NA	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	NA	PE1	2
+NX_Q56UQ5	TPT1-like protein	140	15757	5.81	0	NA	NA	NA	NA	Belongs to the TCTP family.	NA	PE2	X
+NX_Q56VL3	OCIA domain-containing protein 2	154	16954	9.24	0	Endosome;Mitochondrion	NA	NA	NA	NA	NA	PE1	4
+NX_Q587I9	Vesicle transport protein SFT2C	215	21790	9.96	4	Membrane	NA	May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.	NA	Belongs to the SFT2 family.	NA	PE1	2
+NX_Q587J7	Putative ATP-dependent RNA helicase TDRD12	1177	132578	6.3	0	NA	NA	Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.	NA	NA	PIWI-interacting RNA (piRNA) biogenesis	PE1	19
+NX_Q587J8	KHDC3-like protein	217	24306	9.47	0	NA	Hydatidiform mole, recurrent, 2	NA	NA	Belongs to the KHDC1 family.	NA	PE1	6
+NX_Q58A44	Prostate collagen triple helix protein	107	10968	10.45	0	Cytoplasm	NA	May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.	NA	NA	NA	PE1	13
+NX_Q58A45	PAN2-PAN3 deadenylation complex subunit PAN3	887	95613	8.8	0	P-body	NA	Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.	NA	Belongs to the protein kinase superfamily. PAN3 family.	RNA degradation;Deadenylation of mRNA	PE1	13
+NX_Q58DX5	Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2	795	88682	5.78	1	Membrane;Nucleoplasm	NA	May be catalytically inactive.	NA	Belongs to the peptidase M28 family. M28B subfamily.	NA	PE1	3
+NX_Q58EX2	Protein sidekick-2	2172	239396	6.62	1	Nucleoplasm;Synapse;Cell membrane	NA	Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions.	NA	Belongs to the sidekick family.	SDK interactions	PE1	17
+NX_Q58EX7	Puratrophin-1	1191	130803	5.43	0	Cell junction	NA	Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.	NA	NA	NA	PE1	16
+NX_Q58F21	Bromodomain testis-specific protein	947	107954	9.05	0	Nucleus	Spermatogenic failure 21	Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time (PubMed:22901802). In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.	NA	NA	NA	PE1	1
+NX_Q58FF3	Putative endoplasmin-like protein	399	45859	5.14	0	NA	NA	Putative molecular chaperone.	NA	Belongs to the heat shock protein 90 family.	NA	PE5	15
+NX_Q58FF6	Putative heat shock protein HSP 90-beta 4	505	58264	4.65	0	Cytoplasm	NA	Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.	NA	Belongs to the heat shock protein 90 family.	NA	PE5	15
+NX_Q58FF7	Putative heat shock protein HSP 90-beta-3	597	68325	4.71	0	Cytoplasm	NA	Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.	NA	Belongs to the heat shock protein 90 family.	NA	PE5	4
+NX_Q58FF8	Putative heat shock protein HSP 90-beta 2	381	44349	4.79	0	Cytoplasm	NA	Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.	NA	Belongs to the heat shock protein 90 family.	NA	PE1	4
+NX_Q58FG0	Putative heat shock protein HSP 90-alpha A5	334	38738	6.15	0	Cytoplasm	NA	Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.	NA	Belongs to the heat shock protein 90 family.	NA	PE1	3
+NX_Q58FG1	Putative heat shock protein HSP 90-alpha A4	418	47712	5.07	0	Cytoplasm	NA	Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.	NA	Belongs to the heat shock protein 90 family.	NA	PE5	4
+NX_Q58G82	Putative synaptotagmin-14-like protein	188	21436	9.56	0	NA	NA	Plays a role in melanocyte differentiation; enhances dendrite outgrowth, melanin content and tyrosinase activity through the modulation of ERK and/or CREB pathways (PubMed:23999003).	NA	Belongs to the synaptotagmin family.	NA	PE5	4
+NX_Q58HT5	Acyl-CoA wax alcohol acyltransferase 1	328	37759	9.06	2	Endoplasmic reticulum membrane	NA	Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15671038). Shows a strong preference for decyl alcohol (C10), with less activity towards C16 and C18 alcohols (PubMed:15671038). Shows a strong preference for saturated acyl-CoAs (PubMed:15671038).	NA	Belongs to the diacylglycerol acyltransferase family.	Arachidonic acid metabolism;Wax biosynthesis	PE1	X
+NX_Q58WW2	DDB1- and CUL4-associated factor 6	860	96292	5.14	0	Nucleoplasm;Focal adhesion;Nucleus	NA	Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	NA	NA	Protein modification; protein ubiquitination.;Neddylation	PE1	1
+NX_Q59EK9	RUN domain-containing protein 3A	446	49747	5.19	0	Cytoplasmic vesicle	NA	May act as an effector of RAP2A in neuronal cells.	NA	Belongs to the RUNDC3 family.	NA	PE1	17
+NX_Q59GN2	Putative 60S ribosomal protein L39-like 5	51	6323	12.32	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL39 family.	NA	PE5	3
+NX_Q59H18	Serine/threonine-protein kinase TNNI3K	835	92851	6.27	0	Cytoplasm;Nucleus	Cardiac conduction disease with or without dilated cardiomyopathy	May play a role in cardiac physiology.	Autophosphorylated.	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	NA	PE1	1
+NX_Q5BIV9	Shadow of prion protein	151	14522	11.36	0	Cell membrane	NA	Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).	N-glycosylated.	Belongs to the SPRN family.	Post-translational modification: synthesis of GPI-anchored proteins	PE2	10
+NX_Q5BJD5	Transmembrane protein 41B	291	32513	9.6	6	Peroxisome;Endoplasmic reticulum membrane	NA	Required for normal motor neuron development (By similarity). Required for autophagosome formation (PubMed:30093494).	NA	Belongs to the TMEM41 family.	NA	PE1	11
+NX_Q5BJE1	Coiled-coil domain-containing protein 178	867	102011	6.34	0	NA	NA	NA	NA	NA	NA	PE1	18
+NX_Q5BJF2	Sigma intracellular receptor 2	176	20848	9.42	4	Endoplasmic reticulum;Rough endoplasmic reticulum membrane;Nucleus membrane	NA	Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337). Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588).	NA	Belongs to the TMEM97/sigma-2 receptor family.	NA	PE1	17
+NX_Q5BJF6	Outer dense fiber protein 2	829	95401	7.53	0	Centriole;Cilium;Spindle pole;Centrosome;Flagellum	NA	Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.	Tyrosine phosphorylated. Phosphorylated by TSSK4 on Ser-95.	Belongs to the ODF2 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	9
+NX_Q5BJH2	Transmembrane protein 128	165	18822	6.27	4	Membrane	NA	NA	NA	NA	NA	PE1	4
+NX_Q5BJH7	Protein YIF1B	314	34435	9.21	5	Membrane;Golgi apparatus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the YIF1 family.	NA	PE1	19
+NX_Q5BKT4	Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase	473	55606	9.4	12	Endoplasmic reticulum membrane	NA	Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.	NA	Belongs to the ALG10 glucosyltransferase family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	PE1	12
+NX_Q5BKU9	Oxidoreductase-like domain-containing protein 1	147	15855	8.57	0	Cytoplasmic vesicle;Cytosol	NA	NA	NA	NA	NA	PE1	17
+NX_Q5BKX5	UPF0692 protein C19orf54	351	37779	7.13	0	NA	NA	NA	NA	Belongs to the UPF0692 family.	NA	PE1	19
+NX_Q5BKX6	Solute carrier family 45 member 4	768	83878	5.33	12	Membrane;Cell membrane	NA	NA	NA	Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.	NA	PE1	8
+NX_Q5BKX8	Caveolae-associated protein 4	364	41899	8.29	0	Golgi apparatus;Cytoplasm;Cell membrane;Sarcomere;Nucleoplasm;Caveola;Cytosol;Sarcolemma	NA	Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105).	NA	Belongs to the CAVIN family.	NA	PE1	9
+NX_Q5BKY1	Leucine-rich repeat-containing protein 10	277	31642	8.79	0	Nucleus	NA	May play important roles in cardiac development and/or cardiac function.	NA	NA	NA	PE1	12
+NX_Q5BKY6	Putative uncharacterized protein DKFZp434K191	102	10947	7.82	0	NA	NA	NA	NA	NA	NA	PE1	22
+NX_Q5BKY9	Protein FAM133B	247	28385	10.02	0	Nucleus	NA	NA	NA	Belongs to the FAM133 family.	NA	PE1	7
+NX_Q5BKZ1	DBIRD complex subunit ZNF326	582	65654	5.08	0	Golgi apparatus;Nucleoplasm;Nucleus matrix;Cytoplasmic vesicle	NA	Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro.	NA	Belongs to the AKAP95 family.	NA	PE1	1
+NX_Q5BLP8	Neuropeptide-like protein C4orf48	95	10170	8.69	0	Cytosol;Secreted	NA	NA	NA	NA	NA	PE1	4
+NX_Q5BN46	UPF0691 protein C9orf116	136	15260	9.06	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the UPF0691 family.	NA	PE1	9
+NX_Q5BVD1	TPA-induced transmembrane protein	217	24295	4.02	1	Endoplasmic reticulum membrane	NA	NA	NA	NA	NA	PE1	3
+NX_Q5C9Z4	Nucleolar MIF4G domain-containing protein 1	860	96257	8.28	0	Nucleolus	NA	Plays a role in targeting PPP1CA to the nucleolus.	NA	Belongs to the CWC22 family.	NA	PE1	7
+NX_Q5CZ79	Ankyrin repeat domain-containing protein 20B	823	93909	8.55	0	NA	NA	NA	NA	NA	NA	PE2	2
+NX_Q5CZA5	Zinc finger protein 805	627	71143	7.83	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q5CZC0	Fibrous sheath-interacting protein 2	6907	780607	6.27	0	Mitochondrion;Cytoskeleton	Spermatogenic failure 34	Plays a role in spermatogenesis.	NA	NA	NA	PE1	2
+NX_Q5D0E6	DALR anticodon-binding domain-containing protein 3	543	59363	7.07	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	3
+NX_Q5D1E8	Endoribonuclease ZC3H12A	599	65699	6.5	0	Cytoplasm;Nucleoplasm;P-body;Rough endoplasmic reticulum membrane;Cytosol;Cytoplasmic granule;Nucleus	NA	(Microbial infection) Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species.;(Microbial infection) Binds to Japanese encephalitis virus (JEV) and Dengue virus (DEN) RNAs.;Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:26320658, PubMed:26134560, PubMed:22561375). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (By similarity).	Proteolytically cleaved between Arg-111 and Arg-214 by MALT1 in activated T-cells; cleavage at Arg-111 is critical for promoting ZC3H12A degradation in response to T-cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling T-cell activation and Th17 cell differentiation.;(Microbial infection) Rapidly degraded in activated T-cells in response to phorbol 13-acetate 12-myristate (PMA) during HIV-1 viral infection (PubMed:24191027).;Ubiquitinated; ubiquitination is induced in response to interleukin IL1 receptor stimuli in a IKBKB/IKKB and IRAK1-dependent manner, leading to proteasome-mediated degradation (By similarity).;Phosphorylated by IRAK1; phosphorylation is necessary for subsequent phosphorylation by the I-kappa-B-kinase (IKK) complex. Phosphorylated by I-kappa-B-kinase (IKK) subunits IKBKB/IKKB and CHUK/IKKA at Ser-438 and Ser-442; these phosphorylations promote ubiquitin proteasome-mediated degradation of ZC3H12A and hence facilitates rapid and robust production of IL-6 mRNA in response to toll-like receptor (TLR) or IL-1 receptor stimuli (By similarity).	Belongs to the ZC3H12 family.	NA	PE1	1
+NX_Q5D862	Filaggrin-2	2391	248073	8.45	0	Cytoplasm;Cytoplasmic granule	Peeling skin syndrome 6	Essential for normal cell-cell adhesion in the cornified cell layers (PubMed:29758285). Important for proper integrity and mechanical strength of the stratum corneum of the epidermis (PubMed:29505760).	May be processed by calpain-1/CAPN1 in the uppermost epidermal layers.;Deiminated by PADI1, PADI2 or PADI3 in vitro. The deiminated form is degraded by calpain-1/CAPN1 more quickly and into shorter peptides than the intact protein.	In the N-terminal section; belongs to the S-100 family.;Belongs to the S100-fused protein family.	Neutrophil degranulation	PE1	1
+NX_Q5DID0	Uromodulin-like 1	1318	144294	5.75	1	Cytoplasm;Cell membrane	NA	NA	NA	NA	NA	PE2	21
+NX_Q5DJT8	Cancer/testis antigen family 45 member A2	189	21363	9.67	0	NA	NA	NA	NA	Belongs to the CT45 family.	NA	PE2	X
+NX_Q5DT21	Serine protease inhibitor Kazal-type 9	86	9756	9.17	0	Nucleoplasm;Secreted;Cytoplasmic vesicle	NA	Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.	NA	NA	Formation of the cornified envelope	PE1	5
+NX_Q5DX21	Immunoglobulin superfamily member 11	431	46120	6.63	1	Nucleoplasm;Cytosol;Cell junction;Cell membrane	NA	Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.	N-glycosylated.	NA	NA	PE1	3
+NX_Q5EB52	Mesoderm-specific transcript homolog protein	335	38830	9.75	3	Golgi apparatus;Cytosol;Endoplasmic reticulum membrane	NA	NA	NA	Belongs to the AB hydrolase superfamily.	NA	PE1	7
+NX_Q5EBL2	Zinc finger protein 628	1059	110887	8.69	0	Nucleoplasm;Nucleus	NA	Transcription activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3' (By similarity).	NA	NA	NA	PE1	19
+NX_Q5EBL4	RILP-like protein 1	403	47108	5.13	0	Centriole;Cell membrane;Cilium basal body;Nucleoplasm;Cytosol	NA	Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (PubMed:14668488). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (PubMed:30398148).	S-nitrosylation is required for the interaction with GAPDH.	Belongs to the RILPL family.	NA	PE1	12
+NX_Q5EBL8	PDZ domain-containing protein 11	140	16131	6.65	0	Cytoplasm;Cell membrane;Adherens junction;Secreted;Nucleus	NA	Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.	NA	NA	Ion transport by P-type ATPases;Biotin transport and metabolism;Vitamin B5 (pantothenate) metabolism;Transport of vitamins, nucleosides, and related molecules;Ion influx/efflux at host-pathogen interface	PE1	X
+NX_Q5EBM0	UMP-CMP kinase 2, mitochondrial	449	49448	6.57	0	Mitochondrion	NA	May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.	NA	Belongs to the thymidylate kinase family.	Pyrimidine metabolism;Metabolic pathways	PE1	2
+NX_Q5EBM4	Putative zinc finger protein 542	170	19729	9.47	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE5	19
+NX_Q5EBN2	Putative tripartite motif-containing protein 61	209	24047	8.83	0	Endoplasmic reticulum;Nucleolus	NA	NA	NA	NA	NA	PE2	4
+NX_Q5EE01	Centromere protein W	88	10061	11.29	0	Kinetochore;Nucleus matrix;Nucleolus;Nucleoplasm;Centromere;Nucleus	NA	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.	NA	Belongs to the CENP-W/WIP1 family.	Deposition of new CENPA-containing nucleosomes at the centromere	PE1	6
+NX_Q5EG05	Caspase recruitment domain-containing protein 16	197	22625	8.72	0	Mitochondrion	NA	Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.	NA	NA	NA	PE1	11
+NX_Q5F1R6	DnaJ homolog subfamily C member 21	531	62028	5.34	0	Cytoplasm;Nucleolus;Nucleus;Cytoplasmic vesicle	Bone marrow failure syndrome 3	May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA.	NA	NA	NA	PE1	5
+NX_Q5FBB7	Shugoshin 1	561	64190	9.27	0	Kinetochore;Nucleoplasm;Spindle pole;Centromere;Centrosome;Cytosol;Nucleus	Chronic atrial and intestinal dysrhythmia	Plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.;Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity.	Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1.;Phosphorylation by NEK2 is essential for chromosome congression in mitosis and for the proper attachment of spindle microtubule to the kinetochore. Phosphorylated by PLK1 and AUKRB.	Belongs to the shugoshin family.	Oocyte meiosis;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	3
+NX_Q5FVE4	Long-chain-fatty-acid--CoA ligase ACSBG2	666	74354	8.67	0	Membrane;Cytoplasm;Cytosol	NA	Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:16371355, PubMed:16762313). Has increased ability to activate oleic and linoleic acid (PubMed:16371355). May play a role in spermatogenesis (PubMed:15685348).	NA	Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.	Fatty acid metabolism;Metabolic pathways;PPAR signaling pathway;Adipocytokine signaling pathway;Synthesis of very long-chain fatty acyl-CoAs	PE1	19
+NX_Q5FWE3	Proline-rich transmembrane protein 3	981	102197	7.7	7	Membrane;Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	3
+NX_Q5FWF4	DNA annealing helicase and endonuclease ZRANB3	1079	123248	8.74	0	Nucleoplasm;Nucleus;Chromosome	NA	DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558).	NA	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	2
+NX_Q5FWF5	N-acetyltransferase ESCO1	840	94983	9.27	0	Nucleus;Chromosome	NA	Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053).	Phosphorylated during mitosis, when associated with chromosomes.	Belongs to the acetyltransferase family. ECO subfamily.	Establishment of Sister Chromatid Cohesion	PE1	18
+NX_Q5FWF6	Zinc finger protein 789	425	49984	9.3	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	7
+NX_Q5FWF7	F-box only protein 48	155	18241	6.9	0	Nucleus	NA	NA	NA	NA	NA	PE1	2
+NX_Q5FYA8	Arylsulfatase H	562	63525	8.48	2	Membrane	NA	NA	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Glycosphingolipid metabolism;The activation of arylsulfatases	PE2	X
+NX_Q5FYB0	Arylsulfatase J	599	67235	9.15	0	Secreted;Cytoskeleton	NA	NA	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Glycosphingolipid metabolism;The activation of arylsulfatases	PE1	4
+NX_Q5FYB1	Arylsulfatase I	569	64030	8.82	0	Golgi apparatus;Endoplasmic reticulum;Secreted	NA	Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts.	The oxidation of Cys-93 residue to 3-oxoalanine (also known as C(alpha)-formylglycine) by SUMF1/Sulfatase-modifying factor 1, seems critical for catalytic activity.	Belongs to the sulfatase family.	Glycosphingolipid metabolism;The activation of arylsulfatases	PE1	5
+NX_Q5GAN3	Probable inactive ribonuclease-like protein 13	156	17845	8.87	0	Secreted	NA	Does not exhibit any ribonuclease activity.	NA	Belongs to the pancreatic ribonuclease family.	NA	PE1	14
+NX_Q5GAN4	Probable inactive ribonuclease-like protein 12	147	17177	6.64	0	Secreted	NA	Does not exhibit any ribonuclease activity.	NA	Belongs to the pancreatic ribonuclease family.	NA	PE2	14
+NX_Q5GAN6	Inactive ribonuclease-like protein 10	216	24008	4.86	0	Secreted	NA	Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity).	The N-terminus is blocked. Glycosylated (By similarity).	Belongs to the pancreatic ribonuclease family.	NA	PE2	14
+NX_Q5GFL6	von Willebrand factor A domain-containing protein 2	755	82012	8.38	0	Secreted	NA	NA	A 55 kDa form is produced by proteolytic cleavage.	NA	NA	PE1	10
+NX_Q5GH70	XK-related protein 9	373	43406	8.55	8	Membrane;Mitochondrion	NA	NA	NA	Belongs to the XK family.	NA	PE1	8
+NX_Q5GH72	XK-related protein 7	579	63826	9.22	7	Membrane	NA	NA	NA	Belongs to the XK family.	NA	PE1	20
+NX_Q5GH73	XK-related protein 6	641	71638	8.19	7	Membrane;Cytoskeleton	NA	NA	NA	Belongs to the XK family.	NA	PE1	8
+NX_Q5GH76	XK-related protein 4	650	71501	8.08	10	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the XK family.	NA	PE1	8
+NX_Q5GH77	XK-related protein 3	459	53448	9.13	10	Cell membrane	NA	NA	NA	Belongs to the XK family.	NA	PE1	22
+NX_Q5GJ75	Tumor necrosis factor alpha-induced protein 8-like protein 3	292	32659	8.75	0	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	NA	Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.	NA	Belongs to the TNFAIP8 family.	PI Metabolism	PE1	15
+NX_Q5GLZ8	Probable E3 ubiquitin-protein ligase HERC4	1057	118563	5.8	0	Cytosol;Nucleolus	NA	Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.	NA	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	10
+NX_Q5H8A3	Neuromedin-S	153	17731	9.76	0	Secreted	NA	Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.	NA	Belongs to the NmU family.	G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (q) signalling events	PE2	2
+NX_Q5H8A4	GPI ethanolamine phosphate transferase 2	983	108173	6.7	12	Cytoplasmic vesicle;Nucleoplasm;Endoplasmic reticulum membrane	Mental retardation, autosomal recessive 53	Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.	NA	Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	4
+NX_Q5H8C1	FRAS1-related extracellular matrix protein 1	2179	244154	5.55	0	Basement membrane	Manitoba oculotrichoanal syndrome;Trigonocephaly 2;Bifid nose, with or without anorectal and renal anomalies	Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development.	NA	Belongs to the FRAS1 family.	NA	PE1	9
+NX_Q5H913	ADP-ribosylation factor-like protein 13A	290	33003	9.24	0	NA	NA	NA	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	X
+NX_Q5H943	Kita-kyushu lung cancer antigen 1	113	12784	10.2	1	Cell membrane	NA	NA	NA	NA	NA	PE1	X
+NX_Q5H9B9	Putative BMP-2-inducible kinase-like protein	411	46091	5.4	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_Q5H9E4	Solute carrier family 25 member 53	307	34481	9.86	6	Mitochondrion inner membrane	NA	NA	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	X
+NX_Q5H9F3	BCL-6 corepressor-like protein 1	1711	182526	6.9	0	Nucleoplasm;Nucleus;Cell membrane	Shukla-Vernon syndrome	Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.	NA	Belongs to the BCOR family.	NA	PE1	X
+NX_Q5H9I0	Transcription factor Dp family member 3	405	44967	5.91	0	Cytoplasm;Nucleus	NA	Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.	NA	Belongs to the E2F/DP family.	NA	PE1	X
+NX_Q5H9J7	Protein BEX5	111	12602	4.73	0	Cytoplasm	NA	NA	Ubiquitinated (Probable). Degraded by the proteasome.	Belongs to the BEX family.	NA	PE1	X
+NX_Q5H9J9	T-complex protein 11 X-linked protein 2	407	46373	5.07	0	NA	NA	NA	NA	Belongs to the TCP11 family.	NA	PE2	X
+NX_Q5H9K5	Zinc finger matrin-type protein 1	638	74755	8.65	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE2	X
+NX_Q5H9L2	Transcription elongation factor A protein-like 5	206	23307	4.74	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the TFS-II family. TFA subfamily.	NA	PE1	X
+NX_Q5H9L4	Transcription initiation factor TFIID subunit 7-like	462	52588	4.55	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Probably functions as a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis (By similarity).	NA	Belongs to the TAF7 family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation	PE1	X
+NX_Q5H9M0	PWWP domain-containing DNA repair factor 3B	696	79040	4.88	0	NA	NA	NA	NA	Belongs to the PWWP3A family.	NA	PE1	X
+NX_Q5H9R4	Armadillo repeat-containing X-linked protein 4	2290	235964	5.65	1	Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the eutherian X-chromosome-specific Armcx family.	NA	PE1	X
+NX_Q5H9R7	Serine/threonine-protein phosphatase 6 regulatory subunit 3	873	97669	4.5	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance.	NA	Belongs to the SAPS family.	COPII-mediated vesicle transport	PE1	11
+NX_Q5H9S7	DDB1- and CUL4-associated factor 17	520	58778	6.58	2	Membrane;Nucleoplasm;Nucleolus	Woodhouse-Sakati syndrome	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	NA	NA	Protein modification; protein ubiquitination.;Neddylation	PE1	2
+NX_Q5H9T9	Fibrous sheath CABYR-binding protein	825	87956	4.22	0	Cytoplasm;Flagellum	NA	May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium.	Phosphorylated by PKA upon spermatozoa capacitation conditions.	NA	NA	PE1	14
+NX_Q5H9U9	Probable ATP-dependent RNA helicase DDX60-like	1706	197674	8.57	0	Cytosol;Cell membrane	NA	NA	NA	Belongs to the helicase family.	NA	PE1	4
+NX_Q5HY64	Putative protein FAM47C	1035	115338	6.74	0	NA	NA	NA	NA	Belongs to the FAM47 family.	NA	PE1	X
+NX_Q5HY92	Fidgetin	759	82146	6.24	0	Cell membrane;Nucleus matrix;Cell junction;Nucleoplasm;Centrosome;Cytoplasmic vesicle;Cytosol	NA	ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.	NA	Belongs to the AAA ATPase family.	NA	PE1	2
+NX_Q5HY98	Zinc finger protein 766	468	54507	9.55	0	Centrosome;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q5HYA8	Meckelin	995	111745	6.34	6	Endoplasmic reticulum membrane;Cilium;Cilium basal body;Cell membrane	Joubert syndrome 6;Meckel syndrome 3;RHYNS syndrome;Nephronophthisis 11;Bardet-Biedl syndrome 14;COACH syndrome	Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC).	NA	NA	Anchoring of the basal body to the plasma membrane	PE1	8
+NX_Q5HYC2	Uncharacterized protein KIAA2026	2103	228087	9.18	0	Nucleoplasm;Cytosol;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	9
+NX_Q5HYI7	Metaxin-3	312	35093	7.64	0	Mitochondrion outer membrane;Mitochondrion	NA	Could function in transport of proteins into the mitochondrion.	NA	Belongs to the metaxin family.	NA	PE1	5
+NX_Q5HYI8	Rab-like protein 3	236	26423	6.6	0	Nucleoplasm	NA	NA	NA	Belongs to the small GTPase superfamily. Rab family.	NA	PE1	3
+NX_Q5HYJ1	Trans-2,3-enoyl-CoA reductase-like	363	42009	9.63	3	Membrane;Endoplasmic reticulum	Ventricular tachycardia, catecholaminergic polymorphic, 3	NA	NA	Belongs to the steroid 5-alpha reductase family.	Synthesis of very long-chain fatty acyl-CoAs	PE1	4
+NX_Q5HYJ3	Protein FAM76B	339	38708	9.38	0	Nucleoplasm;Nucleolus;Nucleus speckle;Nucleus	NA	NA	NA	Belongs to the FAM76 family.	NA	PE1	11
+NX_Q5HYK3	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial	327	37140	6.47	0	Mitochondrion inner membrane;Mitochondrion;Nucleolus	NA	Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.	Cofactor biosynthesis; ubiquinone biosynthesis.;Ubiquinone and other terpenoid-quinone biosynthesis;Metabolic pathways;Ubiquinol biosynthesis	PE1	12
+NX_Q5HYK7	SH3 domain-containing protein 19	790	86525	8.54	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization.	NA	NA	Golgi Associated Vesicle Biogenesis	PE1	4
+NX_Q5HYK9	Zinc finger protein 667	610	70161	9.79	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q5HYL7	Transmembrane protein 196	178	19025	8.52	4	Membrane;Golgi apparatus;Nucleoplasm	NA	NA	NA	NA	NA	PE2	7
+NX_Q5HYM0	Probable ribonuclease ZC3H12B	836	94205	7.6	0	Endoplasmic reticulum;Golgi apparatus;Cytoplasmic vesicle	NA	May function as RNase and regulate the levels of target RNA species.	NA	Belongs to the ZC3H12 family.	NA	PE2	X
+NX_Q5HYN5	Cancer/testis antigen family 45 member A1	189	21273	9.85	0	NA	NA	NA	NA	Belongs to the CT45 family.	NA	PE2	X
+NX_Q5HYR2	Doublesex- and mab-3-related transcription factor C1	192	20139	6.5	0	NA	NA	NA	NA	Belongs to the DMRT family.	NA	PE2	X
+NX_Q5HYW2	NHS-like protein 2	1225	133286	7.66	0	Cell junction;Cell membrane	NA	NA	NA	Belongs to the NHS family.	NA	PE1	X
+NX_Q5HYW3	Retrotransposon Gag-like protein 5	569	64711	4.71	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	X
+NX_Q5I0G3	Putative malate dehydrogenase 1B	518	58651	5.85	0	NA	NA	NA	NA	Belongs to the LDH/MDH superfamily. MDH type 2 family.	NA	PE1	2
+NX_Q5I0X4	Uncharacterized protein C6orf226	101	10566	8.02	0	Nucleus speckle	NA	NA	NA	NA	NA	PE1	6
+NX_Q5I0X7	Tetratricopeptide repeat protein 32	151	17296	4.86	0	Nucleoplasm;Mitochondrion	NA	NA	NA	NA	NA	PE1	2
+NX_Q5I7T1	Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase	473	55448	9.33	12	Cell membrane	NA	Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (PubMed:14525949). Has a role in maintenance of cochlear outer hair cell function (By similarity).	NA	Belongs to the ALG10 glucosyltransferase family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	PE1	12
+NX_Q5IJ48	Protein crumbs homolog 2	1285	134265	5.31	1	Apical cell membrane;Secreted	Focal segmental glomerulosclerosis 9;Ventriculomegaly with cystic kidney disease	Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB. Also required for maintenance of the apical polarity complex during development of the cortex.	O-glucosylated by POGLUT1 at Ser-267; consists of an O-glucose trisaccharide, in which the O-glucose is elongated by the addition of two xylose residues. O-glucosylation is required for localization at the plasma membrane.	Belongs to the Crumbs protein family.	NA	PE1	9
+NX_Q5J5C9	Beta-defensin 121	76	8456	8.99	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	20
+NX_Q5J8M3	ER membrane protein complex subunit 4	183	20087	8.84	2	Membrane;Focal adhesion	NA	May mediate anti-apoptotic activity.	NA	Belongs to the EMC4 family.	NA	PE1	15
+NX_Q5J8X5	Membrane-spanning 4-domains subfamily A member 13	152	17307	8.82	4	Membrane	NA	May be involved in signal transduction as a component of a multimeric receptor complex.	NA	Belongs to the MS4A family.	NA	PE2	11
+NX_Q5JNZ3	Zinc finger protein 311	666	76322	9.03	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	6
+NX_Q5JNZ5	Putative 40S ribosomal protein S26-like 1	115	13002	10.55	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eS26 family.	NA	PE5	X
+NX_Q5JPB2	Zinc finger protein 831	1677	177949	8.67	0	NA	NA	NA	NA	NA	NA	PE1	20
+NX_Q5JPE7	Nodal modulator 2	1267	139439	5.5	1	Endoplasmic reticulum membrane	NA	May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN.	NA	NA	NA	PE1	16
+NX_Q5JPF3	Ankyrin repeat domain-containing protein 36C	1778	199748	8.02	0	NA	NA	NA	NA	Belongs to the ANKRD36 family.	NA	PE1	2
+NX_Q5JPH6	Probable glutamate--tRNA ligase, mitochondrial	523	58689	8.97	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	Combined oxidative phosphorylation deficiency 12	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).	NA	Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.	Porphyrin and chlorophyll metabolism;Aminoacyl-tRNA biosynthesis;Metabolic pathways;Mitochondrial tRNA aminoacylation	PE1	16
+NX_Q5JPI3	Uncharacterized protein C3orf38	329	37541	6.01	0	Nucleoplasm;Cytosol;Cell membrane	NA	May be involved in apoptosis regulation.	NA	NA	NA	PE1	3
+NX_Q5JPI9	EEF1A lysine methyltransferase 2	291	31830	5.77	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	Protein methylation	PE1	10
+NX_Q5JQC4	Cancer/testis antigen 47A	288	30100	4.2	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_Q5JQC9	A-kinase anchor protein 4	854	94477	6.56	0	Flagellum	NA	Major structural component of sperm fibrous sheath. Plays a role in sperm motility.	NA	Belongs to the AKAP110 family.	NA	PE1	X
+NX_Q5JQD4	Putative peptide YY-3	70	7832	4.43	0	Secreted	NA	NA	NA	Belongs to the NPY family.	NA	PE5	X
+NX_Q5JQF7	Putative uncharacterized protein encoded by LINC01556	62	7289	11.22	0	NA	NA	NA	NA	NA	NA	PE4	6
+NX_Q5JQF8	Polyadenylate-binding protein 1-like 2	200	22799	9.18	0	NA	NA	NA	NA	NA	RNA transport;mRNA surveillance pathway;RNA degradation;RNA transport;mRNA surveillance pathway;RNA degradation	PE1	X
+NX_Q5JQS5	Olfactory receptor 2B11	317	35342	9.12	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q5JQS6	Germinal center-associated signaling and motility-like protein	135	15712	6.22	0	Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q5JR12	Protein phosphatase 1J	505	54834	7.19	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the PP2C family.	NA	PE1	1
+NX_Q5JR59	Microtubule-associated tumor suppressor candidate 2	1369	150195	6.23	0	Cytoskeleton	NA	Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.	NA	In the C-terminal section; belongs to the MTUS1 family.	NA	PE1	13
+NX_Q5JR98	Tctex1 domain-containing protein 4	221	23353	9.87	0	NA	NA	NA	NA	Belongs to the dynein light chain Tctex-type family.	NA	PE1	1
+NX_Q5JRA6	Transport and Golgi organization protein 1 homolog	1907	213702	4.76	1	Cytoplasmic vesicle;Endoplasmic reticulum membrane	NA	Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536).	NA	Belongs to the MIA/OTOR family. Tango1 subfamily.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo concentration in the ER;Post-translational protein phosphorylation	PE1	1
+NX_Q5JRC9	Protein FAM47A	791	90592	9.24	0	NA	NA	NA	NA	Belongs to the FAM47 family.	NA	PE1	X
+NX_Q5JRK9	Putative G antigen family E member 3	111	12041	4.06	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q5JRM2	Uncharacterized protein CXorf66	361	39944	9.59	1	Membrane	NA	NA	NA	NA	NA	PE1	X
+NX_Q5JRS4	Olfactory receptor 10J3	329	36549	8.66	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q5JRV8	Transmembrane protein 255A	349	38449	8.23	4	Membrane;Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the TMEM255 family.	NA	PE2	X
+NX_Q5JRX3	Presequence protease, mitochondrial	1037	117413	6.45	0	Mitochondrion matrix;Mitochondrion	NA	Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469). Has an ATP-independent activity (PubMed:16849325). Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155). Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469). Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155). Also degrades other unstructured peptides (PubMed:19196155). It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469). It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469). Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469).	A disulfide bond locks the enzyme in the closed conformation preventing substrate entry into the catalytic chamber.	Belongs to the peptidase M16 family. PreP subfamily.	Mitochondrial protein import	PE1	10
+NX_Q5JS13	Ras-specific guanine nucleotide-releasing factor RalGPS1	557	62133	9.21	0	Cytoplasm;Cell membrane	NA	Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for.	NA	NA	NA	PE1	9
+NX_Q5JS37	NHL repeat-containing protein 3	347	38283	5.98	0	Secreted	NA	NA	NA	NA	Neutrophil degranulation	PE1	13
+NX_Q5JS54	Proteasome assembly chaperone 4	123	13775	6.04	0	Nucleoplasm;Cytoplasm;Mitochondrion	NA	Chaperone protein which promotes assembly of the 20S proteasome.	NA	Belongs to the PSMG4 family.	NA	PE1	6
+NX_Q5JSH3	WD repeat-containing protein 44	913	101366	5.29	0	trans-Golgi network;Golgi apparatus;Endosome membrane;Cytosol;Perinuclear region	NA	Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).	WDR44 is phosphorylated by PASK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	X
+NX_Q5JSJ4	Integrator complex subunit 6-like	861	96673	8.89	0	Mitochondrion;Centrosome;Nucleus	NA	NA	NA	NA	NA	PE1	X
+NX_Q5JSL3	Dedicator of cytokinesis protein 11	2073	237671	7.87	0	Nucleus membrane;Nucleolus	NA	Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42.	NA	Belongs to the DOCK family.	Factors involved in megakaryocyte development and platelet production	PE1	X
+NX_Q5JSP0	FYVE, RhoGEF and PH domain-containing protein 3	725	79401	5.78	0	Nucleoplasm;Cytosol;Cytoplasm;Cytoskeleton	NA	Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).	NA	NA	Regulation of actin cytoskeleton;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	9
+NX_Q5JSQ8	Putative KHDC1-like protein	128	14546	5.41	0	NA	NA	NA	NA	Belongs to the KHDC1 family.	NA	PE5	6
+NX_Q5JSS6	Meiosis expressed gene 1 protein homolog	88	10795	9.14	0	NA	NA	Essential for spermiogenesis.	NA	Belongs to the MEIG1 family.	NA	PE1	10
+NX_Q5JST6	EF-hand domain-containing family member C2	749	87397	7.14	0	Nucleoplasm;Nucleolus;Cell membrane	NA	NA	NA	NA	NA	PE1	X
+NX_Q5JSZ5	Protein PRRC2B	2229	242967	8.55	0	Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	9
+NX_Q5JT25	Ras-related protein Rab-41	222	25038	5.14	0	Cytoplasm	NA	Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.	NA	Belongs to the small GTPase superfamily. Rab family.	Intra-Golgi traffic;RAB geranylgeranylation	PE1	X
+NX_Q5JT78	Putative uncharacterized protein C1orf137	98	10987	7.65	0	NA	NA	NA	NA	NA	NA	PE4	1
+NX_Q5JT82	Krueppel-like factor 17	389	42577	6.27	0	Nucleus	NA	Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_Q5JTB6	Placenta-specific protein 9	97	10309	4.8	0	Secreted	NA	NA	NA	Belongs to the PLAC9 family.	NA	PE1	10
+NX_Q5JTC6	APC membrane recruitment protein 1	1135	124029	4.77	0	Cytoplasmic vesicle;Cytoplasm;Nucleus;Cell membrane	Osteopathia striata with cranial sclerosis	Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.	NA	Belongs to the Amer family.	Degradation of beta-catenin by the destruction complex;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Beta-catenin phosphorylation cascade;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex	PE1	X
+NX_Q5JTD0	Tight junction-associated protein 1	557	61821	5.67	0	Golgi apparatus;Tight junction	NA	NA	NA	NA	Tight junction	PE1	6
+NX_Q5JTD7	Leucine-rich repeat-containing protein 73	316	33409	4.73	0	Cytosol	NA	NA	NA	NA	NA	PE1	6
+NX_Q5JTH9	RRP12-like protein	1297	143702	8.97	1	Cell membrane;Nucleus membrane;Nucleolus;Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the RRP12 family.	NA	PE1	10
+NX_Q5JTJ3	Cytochrome c oxidase assembly factor 6 homolog	125	14116	8.54	0	Nucleoplasm;Mitochondrion intermembrane space;Mitochondrion	Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 4	Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.	NA	Belongs to the cytochrome c oxidase subunit 6B family.	Mitochondrial protein import	PE1	1
+NX_Q5JTN6	WD repeat-containing protein 38	314	34312	8.89	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_Q5JTV8	Torsin-1A-interacting protein 1	583	66248	8.22	1	Nucleus inner membrane;Nucleus membrane	Myopathy, autosomal recessive, with rigid spine and distal joint contractures	Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.	NA	Belongs to the TOR1AIP family.	NA	PE1	1
+NX_Q5JTW2	Centrosomal protein of 78 kDa	689	76396	8.47	0	Centrosome;Cilium basal body;Centriole	Cone-rod dystrophy and hearing loss 1	May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). May play a role in cilium biogenesis (PubMed:27588451).	NA	Belongs to the CEP78 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	9
+NX_Q5JTY5	COBW domain-containing protein 3	395	44038	4.76	0	NA	NA	NA	NA	Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.	NA	PE2	9
+NX_Q5JTZ5	Uncharacterized protein C9orf152	239	26314	8.94	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	9
+NX_Q5JTZ9	Alanine--tRNA ligase, mitochondrial	985	107340	5.87	0	Mitochondrion	Combined oxidative phosphorylation deficiency 8;Leukoencephalopathy, progressive, with ovarian failure	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.	NA	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	6
+NX_Q5JU00	Dynein regulatory complex subunit 5	501	55632	6.31	0	Flagellum;Cytoplasmic vesicle;Flagellum axoneme	NA	Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.	NA	Belongs to the DRC5 family.	NA	PE1	6
+NX_Q5JU67	Cilia- and flagella-associated protein 157	520	60533	8.88	0	Cytosol;Cilium basal body;Cell membrane	NA	Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure.	NA	Belongs to the CFAP157 family.	NA	PE1	9
+NX_Q5JU69	Torsin-2A	321	35714	8.13	0	Endoplasmic reticulum lumen	NA	NA	NA	Belongs to the ClpA/ClpB family. Torsin subfamily.	NA	PE1	9
+NX_Q5JU85	IQ motif and SEC7 domain-containing protein 2	1488	162784	8.78	0	Cytoplasmic vesicle;Cytoplasm	Mental retardation, X-linked 1	Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins.	NA	Belongs to the BRAG family.	Endocytosis	PE1	X
+NX_Q5JUK2	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1	328	34526	5.27	0	Cytoplasm;Nucleus speckle;Nucleus	Spermatogenic failure 32;Ovarian dysgenesis 5	Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity).	NA	NA	NA	PE1	9
+NX_Q5JUK3	Potassium channel subfamily T member 1	1230	138343	7.48	6	Cell membrane	Epileptic encephalopathy, early infantile, 14;Epilepsy, nocturnal frontal lobe, 5	Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).	Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity (By similarity).	Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily.	NA	PE1	9
+NX_Q5JUK9	P antigen family member 3	113	12480	4.61	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q5JUQ0	Protein FAM78A	283	31968	8.22	0	Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	Belongs to the FAM78 family.	NA	PE1	9
+NX_Q5JUR7	Testis-expressed protein 30	227	25585	8.9	0	NA	NA	NA	NA	NA	NA	PE1	13
+NX_Q5JUW0	KRAB domain-containing protein 4	171	20100	5.54	0	NA	NA	NA	NA	NA	Generic Transcription Pathway	PE1	X
+NX_Q5JUX0	Spindlin-3	258	29207	6.31	0	Nucleoplasm	NA	Exhibits H3K4me3-binding activity.	NA	Belongs to the SPIN/STSY family.	NA	PE1	X
+NX_Q5JV73	FERM and PDZ domain-containing protein 3	1810	199209	8.44	0	NA	NA	NA	NA	NA	Neutrophil degranulation	PE1	X
+NX_Q5JVF3	PCI domain-containing protein 2	399	46030	8.78	0	Nucleoplasm;Cytoplasm;Nucleolus;Nuclear pore complex	NA	Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:22307388) (Probable). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells (PubMed:24896180).	NA	Belongs to the CSN12 family.	NA	PE1	13
+NX_Q5JVG2	Zinc finger protein 484	852	98221	8.68	0	Nucleoplasm;Cytosol;Nucleus membrane;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	9
+NX_Q5JVG8	Zinc finger protein 506	444	51537	9.42	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q5JVL4	EF-hand domain-containing protein 1	640	73990	5.82	0	Spindle pole;Spindle;Centrosome	Juvenile absence epilepsy 1;Juvenile myoclonic epilepsy 1	Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization (PubMed:19734894, PubMed:28370826). Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142). May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581).	NA	NA	NA	PE1	6
+NX_Q5JVS0	Intracellular hyaluronan-binding protein 4	413	45785	6.97	0	Cajal body;Cytoplasm;Golgi apparatus;Stress granule;Nucleus speckle;Gem;Nuclear body;Nucleolus;Sarcoplasm;Nucleoplasm;Cytosol;Nucleus	NA	RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Involved in mRNA translation regulation, probably at the initiation step (PubMed:21771594). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).	Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375.;Methylated (PubMed:16879614). Methylation is decreased by phorbol 12-myristate 13-acetate (PMA)-activated PKC, in vitro (PubMed:16879614).	NA	Platelet degranulation	PE1	9
+NX_Q5JVX7	Uncharacterized protein C1orf141	400	46135	9.7	0	Cytoskeleton	NA	NA	NA	NA	NA	PE2	1
+NX_Q5JW98	Calcium homeostasis modulator protein 4	314	35060	6.44	4	Membrane	NA	Pore-forming subunit of a voltage-gated ion channel.	NA	Belongs to the CALHM family.	NA	PE1	6
+NX_Q5JWF2	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	1037	111025	4.91	0	Apical cell membrane;Cell membrane	ACTH-independent macronodular adrenal hyperplasia 1;Pseudohypoparathyroidism 1B;Pseudohypoparathyroidism 1C;GNAS hyperfunction	Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity).	NA	Belongs to the G-alpha family. G(s) subfamily.	Calcium signaling pathway;Vascular smooth muscle contraction;Gap junction;Glutamatergic synapse;Dopaminergic synapse;Long-term depression;Taste transduction;GnRH signaling pathway;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Vasopressin-regulated water reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;Vibrio cholerae infection;Chagas disease (American trypanosomiasis);Amoebiasis;Dilated cardiomyopathy;G alpha (i) signalling events;G alpha (s) signalling events;Hedgehog 'off' state;PKA activation in glucagon signalling;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;Prostacyclin signalling through prostacyclin receptor;G alpha (z) signalling events;Glucagon-type ligand receptors	PE1	20
+NX_Q5JWF8	Actin-like protein 10	245	26751	9.5	0	NA	NA	NA	NA	Belongs to the actin family.	NA	PE1	20
+NX_Q5JWR5	Protein dopey-1	2465	277355	5.88	0	Cytoplasmic vesicle;Nucleoplasm;Golgi apparatus membrane	NA	May be involved in protein traffic between late Golgi and early endosomes.	NA	Belongs to the dopey family.	NA	PE1	6
+NX_Q5JX69	Protein FAM209B	171	19499	9.08	1	Membrane	NA	NA	NA	Belongs to the FAM209 family.	NA	PE1	20
+NX_Q5JX71	Protein FAM209A	171	19603	9.51	1	Membrane	NA	NA	NA	Belongs to the FAM209 family.	NA	PE1	20
+NX_Q5JXA9	Signal-regulatory protein beta-2	342	36968	5.47	1	Membrane;Nucleus	NA	NA	NA	NA	NA	PE1	20
+NX_Q5JXB2	Putative ubiquitin-conjugating enzyme E2 N-like	153	17377	5.66	0	NA	NA	NA	NA	Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin mediated proteolysis	PE1	X
+NX_Q5JXC2	Migration and invasion-inhibitory protein	388	42824	8.68	0	Nucleoplasm;Cytosol	NA	Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.	Is degraded by the ubiquitin-proteasome pathway.	NA	NA	PE1	1
+NX_Q5JXM2	Methyltransferase-like protein 24	366	41330	9.41	0	Secreted	NA	NA	NA	Belongs to the methyltransferase superfamily.	NA	PE2	6
+NX_Q5JXX5	Glycine receptor subunit alpha-4	417	47728	8.5	3	Postsynaptic cell membrane;Cell membrane;Perikaryon;Synapse;Dendrite	NA	Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA4 sub-subfamily.	Neurotransmitter receptors and postsynaptic signal transmission	PE2	X
+NX_Q5JXX7	Transmembrane protein 31	168	19813	6.09	2	Membrane;Nucleolus	NA	NA	NA	NA	NA	PE1	X
+NX_Q5JY77	G-protein coupled receptor-associated sorting protein 1	1395	156865	4.64	0	Cytoplasm;Cytosol	NA	Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.	NA	Belongs to the GPRASP family.	NA	PE1	X
+NX_Q5JYT7	Uncharacterized protein KIAA1755	1200	130846	5.97	0	Golgi apparatus;Nucleolus;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	20
+NX_Q5JZY3	Ephrin type-A receptor 10	1008	109716	6.52	1	Secreted;Cell membrane	NA	Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.	NA	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	1
+NX_Q5K130	Putative chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein	101	10963	9.55	0	NA	NA	NA	NA	NA	NA	PE5	12
+NX_Q5K131	Chronic lymphocytic leukemia up-regulated protein 1	121	14228	9.08	0	Cytoplasm	NA	NA	NA	NA	NA	PE2	12
+NX_Q5K4E3	Polyserase-2	855	91955	5.41	0	Extracellular matrix	NA	Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1.	N-glycosylated.;The 3 protease domains are not proteolytically cleaved.	Belongs to the peptidase S1 family.	NA	PE1	16
+NX_Q5K4L6	Solute carrier family 27 member 3	683	73550	6.64	1	Mitochondrion membrane;Endoplasmic reticulum	NA	Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Synthesis of very long-chain fatty acyl-CoAs	PE1	1
+NX_Q5K651	Sterile alpha motif domain-containing protein 9	1589	184281	7.98	0	Cytoplasm;Cytosol;Cytoplasmic vesicle	MIRAGE syndrome;Tumoral calcinosis, normophosphatemic, familial	May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion.	NA	NA	NA	PE1	7
+NX_Q5KSL6	Diacylglycerol kinase kappa	1271	141829	5.36	0	Membrane;Cytoplasm	NA	Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).	Phosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2).	Belongs to the eukaryotic diacylglycerol kinase family.	Effects of PIP2 hydrolysis	PE1	X
+NX_Q5KU26	Collectin-12	742	81515	5.48	1	Membrane;Golgi apparatus;Cell junction;Cytoplasmic vesicle	NA	Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.	NA	NA	Phagosome;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Scavenging by Class A Receptors	PE1	18
+NX_Q5M775	Cytospin-B	1068	118585	6.29	0	Nucleolus;Membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	NA	NA	Belongs to the cytospin-A family.	NA	PE1	17
+NX_Q5M7Z0	E3 ubiquitin-protein ligase RNFT1	435	49710	8.85	6	Endoplasmic reticulum membrane;Nucleolus	NA	E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.	NA	NA	Protein modification; protein ubiquitination.	PE1	17
+NX_Q5M8T2	Solute carrier family 35 member D3	416	44183	6.94	10	Membrane;Centriolar satellite	NA	May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.	NA	Belongs to the TPT transporter family. SLC35D subfamily.	NA	PE1	6
+NX_Q5M9N0	Coiled-coil domain-containing protein 158	1113	127140	6.08	0	NA	NA	NA	NA	NA	NA	PE1	4
+NX_Q5M9Q1	NKAP-like protein	402	46312	9.73	0	Nucleus	NA	Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.	NA	Belongs to the NKAP family.	NA	PE2	6
+NX_Q5MAI5	Cyclin-dependent kinase-like 4	379	43384	9	0	Cytoplasm	NA	NA	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	2
+NX_Q5MCW4	Zinc finger protein 569	686	79583	8.97	0	Golgi apparatus;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q5MIZ7	Serine/threonine-protein phosphatase 4 regulatory subunit 3B	849	97458	4.87	0	Cytoplasm;Nucleus speckle;Nucleoplasm;Centrosome;Nucleus	NA	Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.	NA	Belongs to the SMEK family.	NA	PE1	2
+NX_Q5MJ07	Sperm protein associated with the nucleus on the X chromosome N5	72	8277	8.6	0	NA	NA	NA	NA	Belongs to the SPAN-X family.	NA	PE2	X
+NX_Q5MJ08	Sperm protein associated with the nucleus on the X chromosome N4	99	11168	9.25	0	NA	NA	NA	NA	Belongs to the SPAN-X family.	NA	PE1	X
+NX_Q5MJ09	Sperm protein associated with the nucleus on the X chromosome N3	141	15595	4.22	0	NA	NA	NA	NA	Belongs to the SPAN-X family.	NA	PE1	X
+NX_Q5MJ10	Sperm protein associated with the nucleus on the X chromosome N2	180	19917	3.86	0	NA	NA	NA	NA	Belongs to the SPAN-X family.	NA	PE1	X
+NX_Q5MJ68	Speedy protein C	293	33166	8.4	0	Cytoplasm	NA	Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.	NA	Belongs to the Speedy/Ringo family.	Oocyte meiosis;Progesterone-mediated oocyte maturation	PE1	11
+NX_Q5MJ70	Speedy protein A	313	36463	9.07	0	Nucleoplasm;Nucleus	NA	Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962).	NA	Belongs to the Speedy/Ringo family.	Oocyte meiosis;Progesterone-mediated oocyte maturation	PE1	2
+NX_Q5MNV8	F-box only protein 47	452	51968	8.69	0	NA	NA	Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.	NA	NA	NA	PE2	17
+NX_Q5MNZ6	WD repeat domain phosphoinositide-interacting protein 3	344	38122	7.53	0	Golgi apparatus;Nucleoplasm;Preautophagosomal structure;Lysosome;Cytosol	Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures	Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735).	NA	Belongs to the WD repeat SVP1 family.	Macroautophagy	PE1	17
+NX_Q5MNZ9	WD repeat domain phosphoinositide-interacting protein 1	446	48673	6.14	0	trans-Golgi network;Golgi apparatus;Clathrin-coated vesicle;Preautophagosomal structure membrane;Nucleoplasm;Endosome;Cytosol;Cytoskeleton	NA	Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy (PubMed:28561066). Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes (PubMed:28561066). There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:28561066). Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.	NA	Belongs to the WD repeat SVP1 family.	Macroautophagy;XBP1(S) activates chaperone genes	PE1	17
+NX_Q5MY95	Ectonucleoside triphosphate diphosphohydrolase 8	495	53904	5.19	2	Nucleoplasm;Cytoplasmic vesicle;Cytosol;Cell membrane	NA	Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.	N-glycosylated.	Belongs to the GDA1/CD39 NTPase family.	Purine metabolism;Pyrimidine metabolism;Phosphate bond hydrolysis by NTPDase proteins	PE1	9
+NX_Q5NDL2	EGF domain-specific O-linked N-acetylglucosamine transferase	527	62011	6.58	0	Nucleoplasm;Cytosol;Endoplasmic reticulum lumen;Nucleus membrane	Adams-Oliver syndrome 4	Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.	NA	Belongs to the glycosyltransferase 61 family.	NA	PE1	3
+NX_Q5NE16	Putative inactive cathepsin L-like protein CTSL3P	218	25059	6.64	0	NA	NA	NA	NA	Belongs to the peptidase C1 family.	NA	PE5	9
+NX_Q5NUL3	Free fatty acid receptor 4	377	42241	9.52	7	Cell membrane	NA	Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.	Phosphorylated. FFA stimulation facilitates phosphorylation.	Belongs to the G-protein coupled receptor 1 family.	G alpha (q) signalling events;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Free fatty acid receptors	PE1	10
+NX_Q5PR19	Putative UPF0607 protein LOC392364	223	24634	10.47	0	NA	NA	NA	NA	Belongs to the UPF0607 family.	NA	PE2	9
+NX_Q5PRF9	Protein Smaug homolog 2	694	75483	6.37	0	Cytoplasm;Cytosol;Nucleus	NA	Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.	NA	Belongs to the SMAUG family.	NA	PE1	19
+NX_Q5PSV4	Breast cancer metastasis-suppressor 1-like protein	323	37629	5.04	0	Nucleoplasm;Nucleus	NA	Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.	NA	Belongs to the BRMS1 family.	NA	PE1	14
+NX_Q5PT55	Sodium/bile acid cotransporter 5	438	48871	9.02	9	Membrane;Cell membrane	NA	NA	NA	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.	NA	PE1	8
+NX_Q5QFB9	Protein PAPPAS	102	12196	9.78	2	Endoplasmic reticulum membrane	NA	NA	NA	NA	NA	PE5	9
+NX_Q5QGS0	Neurite extension and migration factor	1516	167551	6.03	0	Cytoplasm;Nucleoplasm;Midbody;Cytosol;Spindle;Nucleus	Mental retardation, X-linked 98	Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1).	NA	NA	NA	PE1	X
+NX_Q5QGT7	Receptor-transporting protein 2	225	26068	5.63	1	Cell membrane	NA	Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.	NA	Belongs to the TMEM7 family.	Olfactory Signaling Pathway	PE1	3
+NX_Q5QGZ9	C-type lectin domain family 12 member A	265	30762	8.87	1	Cell membrane	NA	Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.	Highly N-glycosylated. Glycosylation varies between cell types.	NA	Neutrophil degranulation	PE1	12
+NX_Q5QJ38	Trichohyalin-like protein 1	904	99275	4.62	0	Nucleolus;Nucleus membrane	NA	NA	NA	Belongs to the S-100 family.	NA	PE1	1
+NX_Q5QJ74	Tubulin-specific chaperone cofactor E-like protein	424	48195	5.23	0	Cytosol;Cytoskeleton	NA	Acts as a regulator of tubulin stability.	NA	NA	NA	PE1	11
+NX_Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	756	84469	5.86	0	Nucleolus;Nucleus	NA	Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.	NA	NA	NA	PE1	1
+NX_Q5QJU3	Alkaline ceramidase 2	275	31309	7.87	7	Golgi apparatus membrane	NA	Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates (PubMed:20089856). Also hydrolyzes dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990). As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage (PubMed:26943039, PubMed:28294157, PubMed:29229990). Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (PubMed:18945876).	NA	Belongs to the alkaline ceramidase family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis	PE1	9
+NX_Q5QNW6	Histone H2B type 2-F	126	13920	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).;Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.	Belongs to the histone H2B family.	Systemic lupus erythematosus;HATs acetylate histones;HDACs deacetylate histones;Ub-specific processing proteases	PE1	1
+NX_Q5QP82	DDB1- and CUL4-associated factor 10	559	60582	7.3	0	Nucleolus	NA	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	NA	Belongs to the WD repeat DCAF10 family.	Protein modification; protein ubiquitination.;Neddylation	PE1	9
+NX_Q5R372	Rab GTPase-activating protein 1-like	815	92513	5.18	0	Golgi apparatus;Early endosome;Cytoplasmic vesicle	Leukemia, acute myelogenous	GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).	NA	NA	NA	PE1	1
+NX_Q5R387	Putative inactive group IIC secretory phospholipase A2	149	16844	8.89	0	Secreted	NA	Inactive phospholipase.	NA	Belongs to the phospholipase A2 family.	NA	PE2	1
+NX_Q5R3F8	Protein phosphatase 1 regulatory subunit 29	820	89687	7.56	1	Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.	NA	NA	NA	PE1	22
+NX_Q5R3I4	Tetratricopeptide repeat protein 38	469	52787	5.61	0	Cytosol	NA	NA	NA	Belongs to the TTC38 family.	NA	PE1	22
+NX_Q5R3K3	Calcium homeostasis modulator protein 6	315	34458	8.87	4	Membrane	NA	Pore-forming subunit of a voltage-gated ion channel.	NA	Belongs to the CALHM family.	NA	PE1	6
+NX_Q5RGS3	Protein FAM74A1	127	14779	10.5	1	Membrane	NA	NA	NA	Belongs to the FAM74 family.	NA	PE1	9
+NX_Q5RHP9	Glutamate-rich protein 3	1530	168466	4.84	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q5RI15	Cytochrome c oxidase assembly protein COX20, mitochondrial	118	13291	9	2	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex IV deficiency	Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:23125284). Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme (PubMed:24403053).	NA	Belongs to the COX20 family.	Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	1
+NX_Q5RIA9	COBW domain-containing protein 5	395	44068	4.76	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.	NA	PE2	9
+NX_Q5RKV6	Exosome complex component MTR3	272	28235	6.06	0	Cytoplasm;Nucleolus;Nucleus	NA	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.	NA	Belongs to the RNase PH family.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;mRNA decay by 3' to 5' exoribonuclease;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	16
+NX_Q5RL73	RNA-binding protein 48	367	41808	8.92	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the RBM48 family.	NA	PE1	7
+NX_Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2	2527	286103	6.35	0	Mitochondrion outer membrane;Endoplasmic reticulum membrane;Lysosome;Perikaryon;Nucleoplasm;Endosome;Synaptic vesicle membrane;Golgi apparatus membrane;Cytoplasmic vesicle;Axon;Dendrite	Parkinson disease 8	Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, autophagy, and vesicle trafficking (PubMed:20949042, PubMed:22012985, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:30635421, PubMed:21850687, PubMed:23395371, PubMed:17114044, PubMed:24687852, PubMed:26014385, PubMed:25201882). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421, PubMed:23395371). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Independent of its kinase activity, inhibits the proteosomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29212815).	Autophosphorylated (PubMed:28202711, PubMed:28720718, PubMed:29127255, PubMed:29212815, PubMed:30635421). Phosphorylation of Ser-910 and either Ser-935 or Ser-1444 facilitates interaction with YWHAG (PubMed:28202711). Phosphorylation of Ser-910 and/or Ser-935 facilitates interaction with SFN (PubMed:28202711).;LRRK2 is phosphorylated by PRKG2;LRRK2 is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	Parkinson's disease;PTK6 promotes HIF1A stabilization	PE1	12
+NX_Q5SGD2	Protein phosphatase 1L	360	41053	5.58	1	Membrane;Nucleoplasm;Cytosol	NA	Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.	NA	Belongs to the PP2C family.	Sphingolipid de novo biosynthesis	PE1	3
+NX_Q5SNT2	Transmembrane protein 201	666	72236	9.42	5	Nucleoplasm;Spindle pole;Nucleus membrane;Nucleus inner membrane	NA	Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860).;May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090).	NA	Belongs to the TMEM201 family.	NA	PE1	1
+NX_Q5SNV9	Uncharacterized protein C1orf167	1468	162423	10.71	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q5SQ64	Lymphocyte antigen 6 complex locus protein G6f	297	32465	8.91	1	Cell membrane	NA	May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.	N-glycosylated.	NA	Platelet degranulation	PE1	6
+NX_Q5SQ80	Ankyrin repeat domain-containing protein 20A2	823	94087	8.12	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q5SQH8	Uncharacterized protein C6orf136	315	35794	8.99	0	NA	NA	NA	NA	NA	NA	PE1	6
+NX_Q5SQI0	Alpha-tubulin N-acetyltransferase 1	421	46810	9.97	0	Cytoplasm;Golgi apparatus;Axon;Focal adhesion;Clathrin-coated pit;Cytosol;Spindle;Cytoskeleton	NA	Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.	Autoacetylation strongly increases tubulin acetylation.	Belongs to the acetyltransferase ATAT1 family.	Cilium Assembly	PE1	6
+NX_Q5SQN1	Synaptosomal-associated protein 47	464	52562	8.87	0	Endomembrane system;Perinuclear region;Cytosol	NA	Plays a role in intracellular membrane fusion.	NA	Belongs to the SVAP1 family.	SNARE interactions in vesicular transport	PE1	1
+NX_Q5SQQ9	Ventral anterior homeobox 1	334	34713	9.47	0	Nucleoplasm;Nucleolus;Nucleus	Microphthalmia, syndromic, 11	Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity).	NA	Belongs to the EMX homeobox family.	NA	PE1	10
+NX_Q5SQS7	SH2 domain-containing protein 4B	431	51232	5.87	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_Q5SQS8	Uncharacterized protein C10orf120	335	39268	9.5	0	NA	NA	NA	NA	NA	NA	PE1	10
+NX_Q5SR53	Putative uncharacterized protein PIK3CD-AS1	167	18168	9.65	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q5SR56	Hippocampus abundant transcript-like protein 1	506	54545	5.16	12	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE1	9
+NX_Q5SRD0	WASH complex subunit 2D	308	33372	5.2	0	NA	NA	NA	NA	Belongs to the FAM21 family.	NA	PE3	10
+NX_Q5SRD1	Putative mitochondrial import inner membrane translocase subunit Tim23B	257	28048	9.47	2	Mitochondrion inner membrane	NA	May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. The PAM complex (By similarity).	NA	Belongs to the Tim17/Tim22/Tim23 family.	NA	PE5	10
+NX_Q5SRE5	Nucleoporin NUP188 homolog	1749	196043	6.27	0	Nucleoplasm;Cytosol;Nucleolus;Nuclear pore complex	NA	May function as a component of the nuclear pore complex (NPC).	NA	NA	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	9
+NX_Q5SRE7	Phytanoyl-CoA dioxygenase domain-containing protein 1	291	32411	5.88	0	Nucleus speckle	NA	Probably lack enzyme activity.;Has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA.	NA	Belongs to the PhyH family. PHYHD1 subfamily.	NA	PE1	9
+NX_Q5SRH9	Tetratricopeptide repeat protein 39A	613	69778	7.25	0	Centrosome	NA	NA	NA	Belongs to the TTC39 family.	NA	PE1	1
+NX_Q5SRI9	Glycoprotein endo-alpha-1,2-mannosidase	462	53671	9.14	1	Golgi apparatus;Golgi apparatus membrane	NA	NA	Undergoes proteolytic cleavage in the C-terminal region.	Belongs to the glycosyl hydrolase 99 family.	N-glycan trimming and elongation in the cis-Golgi	PE1	6
+NX_Q5SRN2	Testis-expressed basic protein 1	563	61626	9.28	2	Membrane	NA	NA	NA	NA	NA	PE1	6
+NX_Q5SRR4	Lymphocyte antigen 6 complex locus protein G5c	150	16650	8.04	0	Nucleoplasm;Cytosol;Secreted	NA	May have a role in hematopoietic cell differentiation.	N-glycosylated.	NA	NA	PE1	6
+NX_Q5SSG8	Mucin-21	566	54228	4.8	1	Cell membrane	NA	NA	O-glycosylated.	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	6
+NX_Q5SSJ5	Heterochromatin protein 1-binding protein 3	553	61207	9.69	0	Nucleus speckle;Nucleus;Chromosome	NA	Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).	NA	NA	NA	PE1	1
+NX_Q5SSQ6	Suppressor APC domain-containing protein 1	148	16650	7.88	0	Cytoplasmic vesicle;Cell junction	NA	NA	NA	NA	NA	PE2	6
+NX_Q5ST30	Valine--tRNA ligase, mitochondrial	1063	118490	6.56	0	Mitochondrion	Combined oxidative phosphorylation deficiency 20	NA	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	6
+NX_Q5STR5	Small integral membrane protein 40	79	8950	4.39	1	Membrane	NA	NA	NA	NA	NA	PE1	6
+NX_Q5SV17	Transmembrane protein 240	173	19908	7.71	2	Synapse;Cell membrane	Spinocerebellar ataxia 21	NA	NA	Belongs to the TMEM240 family.	NA	PE1	1
+NX_Q5SV97	PGC-1 and ERR-induced regulator in muscle protein 1	790	81351	5.4	0	Cytoplasm;Nucleus	NA	Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.	NA	NA	Transcriptional activation of mitochondrial biogenesis	PE1	1
+NX_Q5SVJ3	Uncharacterized protein C1orf100	147	17617	9.64	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	1
+NX_Q5SVQ8	Zinc finger and BTB domain-containing protein 41	909	105192	8.17	0	Nucleoplasm;Cytosol;Nucleus membrane;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	1
+NX_Q5SVS4	Kidney mitochondrial carrier protein 1	291	32475	9.49	6	Nucleoplasm;Mitochondrion inner membrane	NA	Probable transporter.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	13
+NX_Q5SVZ6	Zinc finger MYM-type protein 1	1142	128717	7.51	0	Centriolar satellite;Nucleus	NA	NA	NA	NA	NA	PE1	1
+NX_Q5SW24	Dapper homolog 2	774	82700	9.09	0	NA	NA	Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).	NA	Belongs to the dapper family.	NA	PE1	6
+NX_Q5SW79	Centrosomal protein of 170 kDa	1584	175293	6.64	0	Spindle;Centriole	NA	Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092).	Phosphorylated; probably by PLK1.;CEP170 is phosphorylated by PLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the CEP170 family.	NA	PE1	1
+NX_Q5SW96	Low density lipoprotein receptor adapter protein 1	308	33885	6.25	0	Cytoplasm;Cytoskeleton	Hypercholesterolemia, autosomal recessive	Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).	NA	NA	Endocytosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;LDL clearance;Chylomicron clearance	PE1	1
+NX_Q5SWA1	Protein phosphatase 1 regulatory subunit 15B	713	79152	4.59	0	Golgi apparatus	Microcephaly, short stature, and impaired glucose metabolism 2	Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.	NA	Belongs to the PPP1R15 family.	NA	PE1	1
+NX_Q5SWH9	Transmembrane protein 69	247	27551	9.98	5	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_Q5SWL7	PRAME family member 14	426	49433	8.7	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE3	1
+NX_Q5SWL8	PRAME family member 19	479	55208	7.99	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE3	1
+NX_Q5SWW7	Uncharacterized protein C10orf55	151	16057	6.95	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	10
+NX_Q5SWX8	Protein odr-4 homolog	454	51103	5.62	2	Membrane;Nucleoplasm;Cell membrane	NA	May play a role in the trafficking of a subset of G-protein coupled receptors.	NA	Belongs to the ODR-4 family.	NA	PE1	1
+NX_Q5SXH7	Pleckstrin homology domain-containing family S member 1	462	51763	5.55	0	Cytoplasmic vesicle;Centrosome	NA	NA	NA	NA	NA	PE1	10
+NX_Q5SXM1	Zinc finger protein 678	525	61411	9.36	0	Nucleolus;Cytosol;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q5SXM2	snRNA-activating protein complex subunit 4	1469	159433	8.51	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.	NA	NA	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA polymerase II transcribes snRNA genes	PE1	9
+NX_Q5SXM8	DNL-type zinc finger protein	178	19204	9.88	0	Nucleoplasm;Mitochondrion	NA	May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.	NA	NA	NA	PE1	9
+NX_Q5SY13	Putative uncharacterized protein encoded by COL5A1-AS1	56	6588	10.35	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_Q5SY16	Polynucleotide 5'-hydroxyl-kinase NOL9	702	79323	9.3	0	Nucleus;Nucleolus;Cytoskeleton	NA	Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA.	NA	Belongs to the Clp1 family. NOL9/GRC3 subfamily.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	1
+NX_Q5SY68	Protein S100-A7-like 2	101	11302	4.99	0	NA	NA	NA	NA	Belongs to the S-100 family.	NA	PE1	1
+NX_Q5SY80	Cation channel sperm-associated protein subunit epsilon	951	109662	6.86	1	Flagellum membrane	NA	Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.	NA	Belongs to the CATSPERD family.	NA	PE1	1
+NX_Q5SY85	Protein FAM201A	155	16478	9.12	0	NA	NA	NA	NA	NA	NA	PE4	9
+NX_Q5SYB0	FERM and PDZ domain-containing protein 1	1578	173437	5.14	0	Cytosol;Cell membrane	NA	Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.	NA	NA	NA	PE1	9
+NX_Q5SYC1	Clavesin-2	327	38000	5.8	0	Early endosome membrane;Clathrin-coated vesicle;trans-Golgi network membrane	NA	Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).	NA	NA	Lysosome Vesicle Biogenesis	PE1	6
+NX_Q5SYE7	NHS-like protein 1	1610	170668	6.52	0	Nucleoplasm;Nucleus membrane	NA	NA	NA	Belongs to the NHS family.	NA	PE1	6
+NX_Q5SZB4	Uncharacterized protein C9orf50	431	47639	10.38	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q5SZD1	Uncharacterized protein C6orf141	244	26754	8.14	0	Nucleus membrane	NA	NA	NA	NA	NA	PE1	6
+NX_Q5SZD4	Glycine N-acyltransferase-like protein 3	288	32704	9.06	0	NA	NA	Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway.	NA	Belongs to the glycine N-acyltransferase family.	Lipid metabolism.;Conjugation of salicylate with glycine;Conjugation of benzoate with glycine	PE1	6
+NX_Q5SZI1	Low-density lipoprotein receptor class A domain-containing protein 2	272	28581	5.45	1	Membrane	NA	NA	NA	Belongs to the LDLR family.	NA	PE1	1
+NX_Q5SZJ8	BEN domain-containing protein 6	279	31222	8.54	0	Nucleoplasm;Nucleus;Cell membrane	NA	Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214).	NA	NA	NA	PE1	6
+NX_Q5SZK8	FRAS1-related extracellular matrix protein 2	3169	351157	4.89	1	Cytosol;Cell membrane	Fraser syndrome 2	Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.	NA	Belongs to the FRAS1 family.	NA	PE1	13
+NX_Q5SZL2	Centrosomal protein of 85 kDa-like	805	91808	5.98	0	Centrosome	NA	NA	NA	Belongs to the CEP85 family.	NA	PE1	6
+NX_Q5SZQ8	CUGBP Elav-like family member 3	465	50548	8.74	0	Cytoplasm;Nucleoplasm;Nucleus	NA	RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.	NA	Belongs to the CELF/BRUNOL family.	NA	PE1	1
+NX_Q5T011	KICSTOR complex protein SZT2	3432	378029	5.85	0	Lysosome membrane;Peroxisome;Nucleoplasm;Cytoplasmic vesicle;Cytoskeleton	Epileptic encephalopathy, early infantile, 18	As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity).	NA	NA	NA	PE1	1
+NX_Q5T013	Putative hydroxypyruvate isomerase	277	30406	5.36	0	Golgi apparatus;Cytosol;Cell membrane	NA	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).	NA	Belongs to the hyi family.	Glyoxylate and dicarboxylate metabolism;Metabolic pathways	PE1	1
+NX_Q5T035	Putative uncharacterized protein C9orf129	196	20715	6.78	0	Mitochondrion	NA	NA	NA	NA	NA	PE2	9
+NX_Q5T036	Uncharacterized protein FAM120AOS	256	27929	11.93	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q5T089	MORN repeat-containing protein 1	497	53850	6.64	0	Nucleoplasm;Mitochondrion	NA	NA	NA	NA	NA	PE1	1
+NX_Q5T0B9	Zinc finger protein 362	420	45814	9.7	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_Q5T0D9	Tumor protein p63-regulated gene 1-like protein	272	30212	6.85	0	Presynaptic active zone;Cytosol;Synaptic vesicle membrane;Cytoplasmic vesicle	NA	Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release.	Phosphorylated. Phosphorylation promotes association with synaptic vesicle membranes.	Belongs to the TPRG1 family.	NA	PE1	1
+NX_Q5T0F9	Coiled-coil and C2 domain-containing protein 1B	858	94224	5.18	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.	NA	Belongs to the CC2D1 family.	NA	PE1	1
+NX_Q5T0J3	Putative uncharacterized protein C1orf220	134	15074	9.92	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q5T0J7	Testis-expressed protein 35	233	26518	9.22	0	Cytoskeleton	NA	NA	NA	NA	NA	PE1	1
+NX_Q5T0L3	Spermatogenesis-associated protein 46	261	29150	7.48	0	Nucleus membrane	NA	Play a role in spermiogenesis and fertilization.	NA	NA	NA	PE1	1
+NX_Q5T0N1	Cilia- and flagella-associated protein 70	1121	125721	5.57	0	Cilium	NA	NA	NA	Belongs to the CFAP70 family.	NA	PE1	10
+NX_Q5T0N5	Formin-binding protein 1-like	605	70065	6.2	0	Cytoplasm;Cell cortex;Cell membrane;Cytoplasmic vesicle;Cytosol;Cytoskeleton	NA	Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.	NA	Belongs to the FNBP1 family.	Clathrin-mediated endocytosis	PE1	1
+NX_Q5T0T0	E3 ubiquitin-protein ligase MARCH8	291	32965	8.1	2	Early endosome membrane;Cytoplasmic vesicle membrane;Lysosome membrane	NA	E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.	NA	NA	Protein modification; protein ubiquitination.	PE1	10
+NX_Q5T0U0	Coiled-coil domain-containing protein 122	273	32206	6.54	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	13
+NX_Q5T0W9	Protein FAM83B	1011	114799	9.04	0	Membrane;Cytoplasm	NA	Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.	NA	Belongs to the FAM83 family.	NA	PE1	6
+NX_Q5T0Z8	Uncharacterized protein C6orf132	1188	124034	9.48	0	Golgi apparatus;Cytosol	NA	NA	NA	NA	NA	PE1	6
+NX_Q5T124	UBX domain-containing protein 11	520	57373	5.06	0	Cytosol;Nucleolus;Cytoskeleton	NA	May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).	NA	NA	NA	PE1	1
+NX_Q5T160	Probable arginine--tRNA ligase, mitochondrial	578	65505	8.41	0	Mitochondrion matrix	Pontocerebellar hypoplasia 6	NA	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	6
+NX_Q5T197	E3 ubiquitin-protein ligase DCST1	706	80712	9.28	6	Cell membrane	NA	E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.	NA	NA	Protein modification; protein ubiquitination.	PE1	1
+NX_Q5T1A1	DC-STAMP domain-containing protein 2	773	86230	8.51	6	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q5T1B0	Axonemal dynein light chain domain-containing protein 1	1012	118027	5.49	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q5T1B1	Uncharacterized protein C10orf91	145	15403	6.9	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_Q5T1C6	Acyl-coenzyme A thioesterase THEM4	240	27130	8.58	0	Cytoplasm;Mitochondrion;Cell membrane;Mitochondrion intermembrane space;Ruffle membrane;Mitochondrion inner membrane	NA	Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.	Phosphorylated.	Belongs to the THEM4/THEM5 thioesterase family.	PIP3 activates AKT signaling;VEGFR2 mediated vascular permeability;CD28 dependent PI3K/Akt signaling;Activation of AKT2;Negative regulation of the PI3K/AKT network;Mitochondrial Fatty Acid Beta-Oxidation	PE1	1
+NX_Q5T1H1	Protein eyes shut homolog	3165	350796	5.5	0	Photoreceptor outer segment;Cilium;Centrosome;Cilium axoneme;Interphotoreceptor matrix	Retinitis pigmentosa 25	Required to maintain the integrity of photoreceptor cells (PubMed:18836446). Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (By similarity).	NA	Belongs to the EYS family.	NA	PE1	6
+NX_Q5T1J5	Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial	151	15490	9.95	0	Mitochondrion	NA	NA	NA	NA	NA	PE5	9
+NX_Q5T1J6	Protein FAM182A	154	17173	6.49	0	NA	NA	NA	NA	NA	NA	PE2	20
+NX_Q5T1M5	FK506-binding protein 15	1219	133630	5.11	0	Cytoplasm;Early endosome;Nucleolus;Cytosol;Axon	NA	May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.	NA	Belongs to the FKBP-type PPIase family.	NA	PE1	9
+NX_Q5T1N1	Protein AKNAD1	836	92864	6.36	0	NA	NA	NA	NA	Belongs to the AKNA family.	NA	PE2	1
+NX_Q5T1Q4	Solute carrier family 35 member F1	408	45346	7.04	10	Membrane;Nucleoplasm;Cytosol;Centriolar satellite	NA	Putative solute transporter.	NA	Belongs to the SLC35F solute transporter family.	NA	PE1	6
+NX_Q5T1R4	Transcription factor HIVEP3	2406	259465	7.85	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.	Phosphorylated on threonine and serine residues.	NA	Regulation of RUNX2 expression and activity	PE1	1
+NX_Q5T1S8	Noncompact myelin-associated protein	102	11082	9.86	1	Cell membrane	NA	Plays a role in myelin formation.	Glycosylated.	NA	NA	PE2	1
+NX_Q5T1V6	Probable ATP-dependent RNA helicase DDX59	619	68810	7.18	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoskeleton	Orofaciodigital syndrome 5	NA	NA	Belongs to the DEAD box helicase family. DDX59 subfamily.	NA	PE1	1
+NX_Q5T200	Zinc finger CCCH domain-containing protein 13	1668	196635	9.45	0	Nucleoplasm;Nucleus speckle;Nucleus membrane;Cytoskeleton	NA	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity).	NA	Belongs to the ZC3H13 family.	NA	PE1	13
+NX_Q5T215	Trafficking protein particle complex subunit 3-like protein	181	20566	8.11	0	cis-Golgi network;Endoplasmic reticulum	NA	May play a role in vesicular transport from endoplasmic reticulum to Golgi.	NA	Belongs to the TRAPP small subunits family. BET3 subfamily.	NA	PE1	6
+NX_Q5T230	Undifferentiated embryonic cell transcription factor 1	341	36439	10.9	0	Nucleus	NA	Acts as a transcriptional coactivator of ATF2.	Phosphorylated.	NA	NA	PE1	10
+NX_Q5T280	Putative methyltransferase C9orf114	376	42009	7.11	0	Spindle;Centrosome;Kinetochore	NA	Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325). Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (PubMed:28431233).	NA	Belongs to the class IV-like SAM-binding methyltransferase superfamily.	NA	PE1	9
+NX_Q5T292	Transmembrane protein 273	105	11325	9.58	1	Membrane	NA	NA	NA	NA	NA	PE1	10
+NX_Q5T2D2	Trem-like transcript 2 protein	321	35127	9.68	1	Cell membrane	NA	Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	6
+NX_Q5T2D3	OTU domain-containing protein 3	398	45124	8.47	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains.	NA	NA	Ovarian tumor domain proteases;Regulation of PTEN stability and activity	PE1	1
+NX_Q5T2E6	Armadillo-like helical domain-containing protein 3	689	78710	6.13	1	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the ARMH3 family.	NA	PE1	10
+NX_Q5T2L2	Putative aldo-keto reductase family 1 member C8	129	14588	5.92	0	Cytoplasm	NA	NA	NA	Belongs to the aldo/keto reductase family.	NA	PE5	10
+NX_Q5T2N8	ATPase family AAA domain-containing protein 3C	411	46380	9.37	0	NA	NA	NA	NA	Belongs to the AAA ATPase family.	NA	PE1	1
+NX_Q5T2Q4	Cyclin-Y-like protein 2	361	41278	6.17	0	NA	NA	NA	NA	Belongs to the cyclin family. Cyclin Y subfamily.	NA	PE3	10
+NX_Q5T2R2	Decaprenyl-diphosphate synthase subunit 1	415	46261	9.17	0	Cytosol;Mitochondrion	Coenzyme Q10 deficiency, primary, 2	Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.	NA	Belongs to the FPP/GGPP synthase family.	Cofactor biosynthesis; ubiquinone biosynthesis.;Terpenoid backbone biosynthesis;Ubiquinol biosynthesis	PE1	10
+NX_Q5T2S8	Armadillo repeat-containing protein 4	1044	115679	7.98	0	Cilium axoneme;Cilium basal body	Ciliary dyskinesia, primary, 23	Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly.	NA	NA	NA	PE1	10
+NX_Q5T2T1	MAGUK p55 subfamily member 7	576	65524	6.65	0	Adherens junction;Cell junction;Membrane;Nucleoplasm;Tight junction	NA	Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.	NA	Belongs to the MAGUK family.	NA	PE1	10
+NX_Q5T2W1	Na(+)/H(+) exchange regulatory cofactor NHE-RF3	519	57129	5.36	0	Cell membrane;Membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).	NA	Belongs to the NHER family.	NA	PE1	1
+NX_Q5T319	Protein FAM182B	152	15775	6.04	0	NA	NA	NA	NA	NA	NA	PE2	20
+NX_Q5T3F8	CSC1-like protein 2	832	94958	7.23	10	Membrane;Cell membrane;Cytoskeleton	NA	Acts as an osmosensitive calcium-permeable cation channel.	NA	Belongs to the CSC1 (TC 1.A.17) family.	NA	PE1	6
+NX_Q5T3I0	G patch domain-containing protein 4	446	50381	9.64	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	1
+NX_Q5T3J3	Ligand-dependent nuclear receptor-interacting factor 1	769	84568	9.72	0	Nucleoplasm;Nucleus matrix;Centriolar satellite;Chromosome	NA	Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211).	NA	Belongs to the LRIF1 family.	NA	PE1	1
+NX_Q5T3U5	Multidrug resistance-associated protein 7	1492	161629	6.64	17	Cell membrane	NA	ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.	NA	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.	ABC transporters;ABC-family proteins mediated transport	PE1	6
+NX_Q5T3Y7	Putative uncharacterized protein BVES-AS1	98	11178	9.18	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_Q5T440	Putative transferase CAF17, mitochondrial	356	38155	9.88	0	Mitochondrion	Spastic paraplegia 74, autosomal recessive;Multiple mitochondrial dysfunctions syndrome 3	Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway.	NA	Belongs to the GcvT family. CAF17 subfamily.	NA	PE1	1
+NX_Q5T442	Gap junction gamma-2 protein	439	47002	7.56	4	Cytosol;Gap junction;Cell membrane	Lymphatic malformation 3;Leukodystrophy, hypomyelinating, 2;Spastic paraplegia 44, autosomal recessive	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.	NA	Belongs to the connexin family. Gamma-type subfamily.	Gap junction assembly	PE1	1
+NX_Q5T447	E3 ubiquitin-protein ligase HECTD3	861	97113	5.47	0	Perinuclear region	NA	E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	1
+NX_Q5T481	RNA-binding protein 20	1227	134357	5.48	0	Golgi apparatus;Nucleolus;Nucleoplasm;Nucleus;Cytoskeleton	Cardiomyopathy, dilated 1DD	RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin).	NA	NA	NA	PE1	10
+NX_Q5T4B2	Inactive glycosyltransferase 25 family member 3	595	67592	5.7	0	Nucleoplasm;Endoplasmic reticulum lumen;Cell junction;Nucleolus	NA	Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro.	NA	Belongs to the glycosyltransferase 25 family.	NA	PE1	9
+NX_Q5T4D3	Protein O-mannosyl-transferase TMTC4	741	82991	9.11	12	Membrane;Cytoplasmic vesicle;Endoplasmic reticulum	NA	Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.	NA	Belongs to the TMTC family.	Protein modification; protein glycosylation.	PE1	13
+NX_Q5T4F4	Protrudin	411	45843	5.09	2	Endoplasmic reticulum membrane;Growth cone membrane;Nucleoplasm;Recycling endosome membrane;Cytoplasmic vesicle;Cytosol	Spastic paraplegia 33, autosomal dominant	Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701).	Phosphorylated. Phosphorylation is induced by NGF through the MAPK/ERK pathway and modulates interaction with RAB11A.	NA	NA	PE1	10
+NX_Q5T4F7	Secreted frizzled-related protein 5	317	35563	8.88	0	Secreted	NA	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.	NA	Belongs to the secreted frizzled-related protein (sFRP) family.	Wnt signaling pathway	PE1	10
+NX_Q5T4H9	Protein CASC10	136	14851	11.17	0	Nucleoplasm	NA	NA	NA	NA	NA	PE2	10
+NX_Q5T4I8	Putative uncharacterized protein C6orf52	152	17383	4.52	0	Nucleus speckle;Cytoskeleton	NA	NA	NA	NA	NA	PE2	6
+NX_Q5T4S7	E3 ubiquitin-protein ligase UBR4	5183	573841	5.7	2	Cytoplasm;Membrane;Nucleoplasm;Centrosome;Cytosol;Nucleus;Cytoskeleton	NA	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.	NA	Belongs to the UBR4 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neutrophil degranulation	PE1	1
+NX_Q5T4T1	Transmembrane protein 170B	132	14360	10.4	3	Centrosome;Cell membrane	NA	Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets (PubMed:29367600).	NA	Belongs to the TMEM170 family.	NA	PE1	6
+NX_Q5T4T6	Synaptonemal complex protein 2-like	812	93599	5.57	0	Nucleoplasm;Centromere;Nucleus	NA	Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes.	NA	Belongs to the SYCP2 family.	NA	PE1	6
+NX_Q5T4W7	Artemin	220	22878	11.7	0	Secreted	NA	Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.	NA	Belongs to the TGF-beta family. GDNF subfamily.	RAF/MAP kinase cascade;NCAM1 interactions;RET signaling	PE1	1
+NX_Q5T5A4	Protein C1orf194	169	19350	9.27	0	Cytoplasm;Cytosol;Nucleus speckle;Cytoskeleton	NA	May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis (PubMed:31199454).	NA	NA	NA	PE1	1
+NX_Q5T5A8	Late cornified envelope protein 3C	94	9729	8.73	0	NA	NA	A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035).	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5T5B0	Late cornified envelope protein 3E	92	9507	9.07	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5T5C0	Syntaxin-binding protein 5	1151	127573	6.96	0	Cytoplasm;Cell membrane;Cytoplasmic vesicle membrane;Synapse;Cytosol;Synaptic vesicle	NA	Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity).	NA	Belongs to the WD repeat L(2)GL family.	NA	PE1	6
+NX_Q5T5D7	Zinc finger protein 684	378	43945	9.06	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q5T5F5	Uncharacterized protein ADAMTSL4-AS1	129	14090	11.14	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q5T5J6	Transcriptional protein SWT1	900	103222	8.98	0	Cytosol	NA	NA	NA	Belongs to the SWT1 family.	NA	PE1	1
+NX_Q5T5M9	Cyclin-J	372	42581	6.75	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	Belongs to the cyclin family.	NA	PE1	10
+NX_Q5T5N4	Uncharacterized protein C6orf118	469	53772	8.61	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	6
+NX_Q5T5P2	Sickle tail protein homolog	1943	214116	6.59	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Required for normal development of intervertebral disks.	NA	NA	NA	PE1	10
+NX_Q5T5S1	Coiled-coil domain-containing protein 183	534	62689	8.93	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_Q5T5U3	Rho GTPase-activating protein 21	1958	217462	7.85	0	Cell membrane;Cell junction;Cytoplasmic vesicle membrane;Golgi apparatus membrane;Cytoskeleton	NA	Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.	Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes.	NA	Rho GTPase cycle	PE1	10
+NX_Q5T5X7	BEN domain-containing protein 3	828	94475	5.29	0	Nucleoplasm;Nucleus;Nucleolus	NA	Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671).	Sumoylated at Lys-20 by SUMO1 and at Lys-512 by SUMO1, SUMO2 and SUMO3. Sumoylation probably occurs sequentially, with that of Lys-20 preceding that of Lys-512. It does not alter association with heterochromatin, but is required for the repression of transcription.	NA	NA	PE1	6
+NX_Q5T5Y3	Calmodulin-regulated spectrin-associated protein 1	1602	177972	6.28	0	Cytosol;Spindle;Cytoskeleton	NA	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24486153, PubMed:24706919, PubMed:24117850). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850).	NA	Belongs to the CAMSAP1 family.	NA	PE1	9
+NX_Q5T601	Adhesion G-protein coupled receptor F1	910	101365	8.91	7	Secreted;Cell membrane	NA	Orphan receptor.	Glycosylated.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	6
+NX_Q5T619	Zinc finger protein 648	568	62341	8.97	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_Q5T653	39S ribosomal protein L2, mitochondrial	305	33301	11.29	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL2 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	6
+NX_Q5T655	Cilia- and flagella-associated protein 58	872	103417	8.44	0	Cytoplasmic vesicle;Cytosol;Cilium;Cell membrane	NA	NA	NA	Belongs to the CFAP58 family.	NA	PE1	10
+NX_Q5T681	Uncharacterized protein C10orf62	223	25128	7.08	0	NA	NA	NA	NA	NA	NA	PE1	10
+NX_Q5T686	Arginine vasopressin-induced protein 1	147	16773	10.84	0	Nucleoplasm;Cell membrane	NA	May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.	NA	NA	NA	PE1	10
+NX_Q5T6C5	Ataxin-7-like protein 2	722	77181	9.4	0	Cytoplasmic vesicle;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	1
+NX_Q5T6F0	DDB1- and CUL4-associated factor 12	453	50517	9.23	0	Cytoplasm;Centrosome	NA	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	NA	Belongs to the WD repeat DCAF12 family.	Protein modification; protein ubiquitination.	PE1	9
+NX_Q5T6F2	Ubiquitin-associated protein 2	1119	117116	6.89	0	Cytosol	NA	NA	NA	NA	NA	PE1	9
+NX_Q5T6J7	Probable gluconokinase	187	20578	5.84	0	Cytosol;Mitochondrion	NA	NA	NA	Belongs to the gluconokinase GntK/GntV family.	Carbohydrate acid metabolism; D-gluconate degradation.	PE1	9
+NX_Q5T6L9	Endoplasmic reticulum membrane-associated RNA degradation protein	678	77788	6.28	2	Cytosol;Endoplasmic reticulum membrane	Periventricular nodular heterotopia 6	May play a role in neuronal migration during embryonic development.	NA	NA	NA	PE1	6
+NX_Q5T6M2	Putative uncharacterized protein encoded by LINC00242	205	23040	11.95	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_Q5T6R2	Putative phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2P1	138	15541	6.89	0	NA	NA	NA	NA	NA	NA	PE5	13
+NX_Q5T6S3	PHD finger protein 19	580	65591	9.08	0	Nucleus	NA	Inhibit transcription from an HSV-tk promoter.;Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2).	NA	Belongs to the Polycomblike family.	PRC2 methylates histones and DNA	PE1	9
+NX_Q5T6V5	Queuosine salvage protein	341	39029	5.61	0	Golgi apparatus	NA	Involved in salvaging queuosine.	NA	Belongs to the queuosine salvage protein family.	NA	PE1	9
+NX_Q5T6X4	Protein FAM162B	162	17685	10.77	1	Membrane	NA	NA	NA	Belongs to the UPF0389 family.	NA	PE1	6
+NX_Q5T6X5	G-protein coupled receptor family C group 6 member A	926	104753	8.29	7	Cell membrane	NA	Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.	N-glycosylated.	Belongs to the G-protein coupled receptor 3 family.	G alpha (q) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	6
+NX_Q5T700	Low-density lipoprotein receptor class A domain-containing protein 1	205	21834	5.33	1	Membrane;Golgi apparatus;Nucleoplasm	NA	NA	NA	Belongs to the LDLR family.	NA	PE1	1
+NX_Q5T742	Uncharacterized protein C10orf25	122	14441	10.26	0	Secreted	NA	NA	NA	NA	NA	PE2	10
+NX_Q5T749	Keratinocyte proline-rich protein	579	64136	8.72	0	Cytoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_Q5T750	Skin-specific protein 32	250	26238	8.41	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q5T751	Late cornified envelope protein 1C	118	11543	8.83	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE2	1
+NX_Q5T752	Late cornified envelope protein 1D	114	11230	8.82	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5T753	Late cornified envelope protein 1E	118	11616	8.71	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5T754	Late cornified envelope protein 1F	118	11654	8.83	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5T764	Interferon-induced protein with tetratricopeptide repeats 1B	474	54993	7.62	0	NA	NA	NA	NA	Belongs to the IFIT family.	Hepatitis C;Herpes simplex infection	PE1	10
+NX_Q5T7B8	Kinesin-like protein KIF24	1368	151903	6.69	0	Centriole	NA	Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Anchoring of the basal body to the plasma membrane	PE1	9
+NX_Q5T7M4	Adipolin	302	32416	9.41	0	Cytoplasmic vesicle;Secreted	NA	Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.	Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN. Insulin enhances endogenous C1QTNF12 cleavage.	Belongs to the adipolin/erythroferrone family.	NA	PE1	1
+NX_Q5T7M9	Divergent protein kinase domain 1A	428	49024	6.92	1	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane	NA	NA	Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.	Belongs to the DIPK family.	NA	PE1	1
+NX_Q5T7N2	LINE-1 type transposase domain-containing protein 1	865	98850	4.87	0	NA	NA	NA	NA	Belongs to the transposase 22 family.	NA	PE1	1
+NX_Q5T7N3	KN motif and ankyrin repeat domain-containing protein 4	995	107342	5.15	0	Cytoplasm;Cytosol;Cytoskeleton	NA	May be involved in the control of cytoskeleton formation by regulating actin polymerization.	NA	NA	NA	PE1	1
+NX_Q5T7N8	Protein FAM27D1	215	24905	11.93	0	NA	NA	NA	NA	Belongs to the FAM27 family.	NA	PE3	9
+NX_Q5T7P2	Late cornified envelope protein 1A	110	10982	8.84	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5T7P3	Late cornified envelope protein 1B	118	11626	8.83	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5T7P6	Transmembrane protein 78	136	15193	4.87	2	Membrane	NA	NA	NA	NA	NA	PE2	1
+NX_Q5T7P8	Synaptotagmin-6	510	57325	8.47	1	Cell membrane;Membrane;Synaptic vesicle membrane;Cytoplasmic vesicle;Cytosol	NA	May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).	NA	Belongs to the synaptotagmin family.	NA	PE1	1
+NX_Q5T7R7	Uncharacterized protein C1orf185	199	22411	7.67	1	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q5T7V8	RAB6-interacting golgin	394	44993	6.66	0	Golgi apparatus;Cytoplasm;Nucleolus;Nucleoplasm;Cytosol	Geroderma osteodysplasticum	NA	NA	Belongs to the GORAB family.	NA	PE1	1
+NX_Q5T7W0	Zinc finger protein 618	954	104956	6.7	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	9
+NX_Q5T7W7	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2	516	58263	6.89	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	9
+NX_Q5T848	Probable G-protein coupled receptor 158	1215	135489	8.57	7	Cytosol;Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 3 family.	NA	PE1	10
+NX_Q5T870	Proline-rich protein 9	116	12904	4.96	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q5T871	Late cornified envelope-like proline-rich protein 1	98	10697	8.44	0	NA	NA	NA	NA	Belongs to the cornifin (SPRR) family.	Formation of the cornified envelope	PE1	1
+NX_Q5T890	DNA excision repair protein ERCC-6-like 2	1561	177127	8.83	0	Mitochondrion;Nucleoplasm;Centrosome;Cytosol;Nucleus	Bone marrow failure syndrome 2	May be involved in early DNA damage response.	Phosphorylated by NEK6.;ERCC6L2 is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	9
+NX_Q5T8A7	Protein phosphatase 1 regulatory subunit 26	1209	127351	8.84	0	Nucleoplasm;Nucleolus	NA	Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation.	NA	NA	NA	PE1	9
+NX_Q5T8D3	Acyl-CoA-binding domain-containing protein 5	534	60092	5.19	1	Peroxisome;Peroxisome membrane	NA	Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.	NA	Belongs to the ATG37 family.	Peroxisomal lipid metabolism;Class I peroxisomal membrane protein import	PE1	10
+NX_Q5T8I3	Protein FAM102B	360	39308	6.62	0	Cytosol;Nucleolus	NA	NA	NA	Belongs to the FAM102 family.	NA	PE1	1
+NX_Q5T8I9	Small RNA 2'-O-methyltransferase	393	44525	5.16	0	Cytoplasm;Focal adhesion;Cell membrane	NA	Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.	NA	Belongs to the methyltransferase superfamily. HEN1 family.	PIWI-interacting RNA (piRNA) biogenesis	PE1	1
+NX_Q5T8P6	RNA-binding protein 26	1007	113597	9.21	0	Nucleus speckle	NA	NA	NA	NA	NA	PE1	13
+NX_Q5T8R8	Uncharacterized protein C9orf66	295	31184	11.77	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_Q5T953	Immediate early response gene 5-like protein	404	42109	6.45	0	Nucleoplasm	NA	NA	NA	Belongs to the IER family.	NA	PE1	9
+NX_Q5T9A4	ATPase family AAA domain-containing protein 3B	648	72573	9.3	0	Mitochondrion inner membrane	NA	May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. May act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.	NA	Belongs to the AAA ATPase family.	Neutrophil degranulation	PE1	1
+NX_Q5T9C2	Protein FAM102A	384	41785	8.83	0	Cytosol	NA	May play a role in estrogen action.	NA	Belongs to the FAM102 family.	NA	PE1	9
+NX_Q5T9C9	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	394	44572	9.63	0	Membrane;Cytoplasm;Cytosol	NA	May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Endocytosis	PE1	9
+NX_Q5T9G4	Armadillo repeat-containing protein 12	340	38632	8.02	0	Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	6
+NX_Q5T9L3	Protein wntless homolog	541	62253	6.98	7	Endoplasmic reticulum membrane;Cell membrane;Endoplasmic reticulum;Cytoplasmic vesicle membrane;Golgi apparatus membrane;Early endosome membrane;Cytosol	NA	Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).	NA	Belongs to the wntless family.	WNT ligand biogenesis and trafficking	PE1	1
+NX_Q5T9S5	Coiled-coil domain-containing protein 18	1454	168962	5.52	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q5T9Z0	Transmembrane epididymal protein 1	273	31315	8.02	6	Membrane	NA	NA	NA	Belongs to the TMEM45 family.	NA	PE2	1
+NX_Q5TA31	E3 ubiquitin-protein ligase RNF187	235	26190	5.7	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.	Ubiquitinated; undergoes 'Lys-48'-linked autoubiquitination in the absence of growth factors and MAP3K1-induced 'Lys-63'-linked polyubiquitination (PubMed:20852630). 'Lys-48'-autoubiquitination leads to degradation by the proteasome, while MAP3K1-induced 'Lys-63'-linked polyubiquitination results in the stabilization of the protein (PubMed:20852630). 'Lys-48'- and 'Lys-63'-linked polyubiquitinations occur most probably on the same 3 C-terminal lysine residues (Lys-195, Lys-223 and Lys-224) and are thus mutually exclusive (PubMed:20852630). Other sites of ubiquitination are not excluded (PubMed:20852630). 'Lys-63'-linked polyubiquitination by TRIM7 in response to growth factor signaling via the MEK/ERK pathway enhances protein stability (PubMed:25851810).;Arginine methylation by PRMT1 stabilizes RNF187 by facilitating K63-linked ubiquitin chain formation, and enables dimerization, c-Jun interaction and subsequent AP1 target gene expression.	NA	Protein modification; protein ubiquitination.	PE1	1
+NX_Q5TA45	Integrator complex subunit 11	600	67663	8.27	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).	NA	Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.	RNA polymerase II transcribes snRNA genes	PE1	1
+NX_Q5TA50	Ceramide-1-phosphate transfer protein	214	24365	6.71	0	Nucleus outer membrane;Cell membrane;Endosome membrane;trans-Golgi network membrane;Cytosol	NA	Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed:28011644). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996).	NA	Belongs to the GLTP family.	Glycosphingolipid metabolism	PE1	1
+NX_Q5TA76	Late cornified envelope protein 3A	89	9146	8.81	0	NA	NA	A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035).	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5TA77	Late cornified envelope protein 3B	95	9812	8.57	0	NA	NA	A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035).	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5TA78	Late cornified envelope protein 4A	99	9980	8.64	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5TA79	Late cornified envelope protein 2A	106	10846	8.32	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5TA81	Late cornified envelope protein 2C	110	11224	8.56	0	NA	NA	Precursors of the cornified envelope of the stratum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5TA82	Late cornified envelope protein 2D	110	11180	8.54	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5TA89	Transcription factor HES-5	166	18226	9.52	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).	NA	NA	Notch signaling pathway;NOTCH2 intracellular domain regulates transcription;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE2	1
+NX_Q5TAA0	Tetratricopeptide repeat protein 22	569	63361	5.29	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q5TAB7	Protein ripply2	128	13906	4.42	0	Nucleus	Spondylocostal dysostosis 6, autosomal recessive	Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity).	NA	Belongs to the ripply family.	NA	PE1	6
+NX_Q5TAG4	Neuroblastoma breakpoint family member 12	1457	167689	4.75	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE2	1
+NX_Q5TAH2	Sodium/hydrogen exchanger 11	1124	129053	6.5	15	Membrane	NA	Involved in pH regulation.	NA	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Stimuli-sensing channels	PE1	1
+NX_Q5TAP6	U3 small nucleolar RNA-associated protein 14 homolog C	766	87188	6.7	0	Nucleolus	NA	Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).	NA	Belongs to the UTP14 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	13
+NX_Q5TAQ9	DDB1- and CUL4-associated factor 8	597	66852	5.21	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	Giant axonal neuropathy 2, autosomal dominant	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	NA	Belongs to the WD repeat DCAF8 family.	Protein modification; protein ubiquitination.;Neddylation	PE1	1
+NX_Q5TAT6	Collagen alpha-1(XIII) chain	717	69950	9.27	1	Postsynaptic cell membrane;Cell membrane	Myasthenic syndrome, congenital, 19	Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625).	NA	NA	Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;Collagen chain trimerization	PE1	10
+NX_Q5TAX3	Terminal uridylyltransferase 4	1644	185166	8.3	0	Cytoplasm;Nucleolus;Cytoplasmic ribonucleoprotein granule;Cytosol;Nucleus	NA	Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:16643855, PubMed:19703396, PubMed:18172165) (By similarity). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351).	NA	Belongs to the DNA polymerase type-B-like family.	Deadenylation of mRNA	PE1	1
+NX_Q5TB30	DEP domain-containing protein 1A	811	92960	8.91	0	Nucleoplasm;Nucleus;Nucleolus	NA	May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.	NA	NA	NA	PE1	1
+NX_Q5TB80	Centrosomal protein of 162 kDa	1403	161943	5.36	0	Cell membrane;Centriole;Cytosol;Spindle;Nucleus	NA	Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules.	NA	Belongs to the CEP162 family.	Anchoring of the basal body to the plasma membrane	PE1	6
+NX_Q5TBA9	Protein furry homolog	3013	338875	5.66	0	Cytoplasm;Spindle pole;Centrosome	NA	Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.	Phosphorylated by AURKA, CDK1 and PLK1.;FRY is phosphorylated by AURKA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the furry protein family.	NA	PE1	13
+NX_Q5TBB1	Ribonuclease H2 subunit B	312	35139	9.19	0	Nucleoplasm;Nucleus	Aicardi-Goutieres syndrome 2	Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.	NA	Belongs to the RNase H2 subunit B family.	DNA replication	PE1	13
+NX_Q5TBC7	Bcl-2-like protein 15	163	17725	4.33	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q5TBE3	Uncharacterized protein C9orf153	101	11254	9.26	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_Q5TBK1	NEDD4-binding protein 2-like 1	243	28981	10.07	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	13
+NX_Q5TC04	Putative uncharacterized protein ATP1A1-AS1	95	10240	6.05	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q5TC12	ATP synthase mitochondrial F1 complex assembly factor 1	328	36437	8.12	0	Mitochondrion	NA	May play an essential role for the assembly of the mitochondrial F1-F0 complex.	NA	Belongs to the ATP11 family.	NA	PE1	1
+NX_Q5TC63	Growth hormone-regulated TBC protein 1	336	38554	9	0	NA	NA	May act as a GTPase-activating protein for Rab family protein(s).	NA	NA	NA	PE1	13
+NX_Q5TC79	Zinc finger and BTB domain-containing protein 37	503	56055	6.3	0	Nucleoplasm;Nucleus;Nucleolus;Cytosol	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	1
+NX_Q5TC82	Roquin-1	1133	125736	6.86	0	Cytosol;P-body;Cytoplasmic granule;Cell membrane	NA	Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25504471, PubMed:25026078). MiRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Show the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670).	Proteolytically cleaved after Arg-510 and Arg-579 by MALT1 in activated CD4(+) T cells; cleavage at Arg-510 and Arg-579 is critical for promoting RC3H1 degradation in response to T-cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling Th17 cell differentiation.	NA	Protein modification; protein ubiquitination.	PE1	1
+NX_Q5TC84	Opioid growth factor receptor-like protein 1	451	51252	5.81	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	Belongs to the opioid growth factor receptor family.	NA	PE1	6
+NX_Q5TCH4	Cytochrome P450 4A22	519	59246	9.21	0	Microsome membrane;Endoplasmic reticulum membrane	NA	Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.	NA	Belongs to the cytochrome P450 family.	Fatty acid metabolism;Arachidonic acid metabolism;Retinol metabolism;Metabolic pathways;PPAR signaling pathway;Vascular smooth muscle contraction;Miscellaneous substrates;Fatty acids;Eicosanoids;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	1
+NX_Q5TCM9	Late cornified envelope protein 5A	118	11795	8.75	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	1481	162949	8.26	0	Tight junction;Cell junction;Nucleus;Cell membrane	NA	Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.	Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.	Belongs to the MAGUK family.	Tight junction	PE1	1
+NX_Q5TCS8	Adenylate kinase 9	1911	221413	4.96	0	Nucleoplasm;Cytoplasm;Nucleus;Nucleus membrane	NA	Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP.	NA	Belongs to the adenylate kinase family.	Interconversion of nucleotide di- and triphosphates	PE1	6
+NX_Q5TCX8	Mitogen-activated protein kinase kinase kinase 21	1036	113957	8.97	0	Cytosol;Cell membrane	NA	Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.	Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	NA	PE1	1
+NX_Q5TCY1	Tau-tubulin kinase 1	1321	142737	5.46	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.	NA	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.	NA	PE1	6
+NX_Q5TCZ1	SH3 and PX domain-containing protein 2A	1133	125289	9.01	0	Cytoplasm;Podosome	NA	Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.	Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR.	Belongs to the SH3PXD2 family.	Invadopodia formation	PE1	10
+NX_Q5TD94	Radial spoke head protein 4 homolog A	716	80733	4.38	0	Nucleoplasm;Cilium axoneme;Cilium	Ciliary dyskinesia, primary, 11	Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules.	NA	Belongs to the flagellar radial spoke RSP4/6 family.	NA	PE1	6
+NX_Q5TD97	Four and a half LIM domains protein 5	284	32720	7.77	0	Nucleus	NA	May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.	NA	NA	NA	PE1	6
+NX_Q5TDH0	Protein DDI1 homolog 2	399	44523	4.95	0	Nucleoplasm;Cytosol;Chromosome	NA	Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612).	NA	Belongs to the DDI1 family.	NA	PE1	1
+NX_Q5TDP6	Lengsin	509	57278	5.96	0	Nucleoplasm;Cytoplasmic vesicle	NA	May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity).	NA	Belongs to the glutamine synthetase family.	NA	PE1	6
+NX_Q5TEA3	Uncharacterized protein C20orf194	1177	132287	6.11	0	Cytosol;Nucleolus	NA	May act as an effector for ARL3.	NA	NA	NA	PE1	20
+NX_Q5TEA6	Protein sel-1 homolog 2	688	77964	9.25	1	Membrane	NA	NA	NA	Belongs to the sel-1 family.	NA	PE1	20
+NX_Q5TEC3	Zinc finger protein 697	545	60461	6.88	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q5TEJ8	Protein THEMIS2	643	72049	5.77	0	Nucleoplasm	NA	May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.	Phosphorylation at Tyr-632 is induced by LPS.	Belongs to the themis family.	NA	PE1	1
+NX_Q5TEU4	Arginine-hydroxylase NDUFAF5, mitochondrial	345	38918	6.14	0	Mitochondrion inner membrane	Mitochondrial complex I deficiency, nuclear type 16	Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages (PubMed:18940309, PubMed:27226634). Acts by mediating hydroxylation of 'Arg-111' of NDUFS7 (PubMed:27226634). May also have methyltransferase activity (Probable).	NA	Belongs to the methyltransferase superfamily.	Complex I biogenesis	PE1	20
+NX_Q5TEV5	Putative uncharacterized protein C1orf134	83	9093	9.72	0	Secreted	NA	NA	NA	NA	NA	PE3	1
+NX_Q5TEZ4	Putative uncharacterized protein encoded by LINC01590	76	8388	8.84	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_Q5TEZ5	Uncharacterized protein C6orf163	329	38553	6.49	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	6
+NX_Q5TF21	Protein SOGA3	947	103199	5.81	1	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the SOGA family.	NA	PE1	6
+NX_Q5TF39	Sodium-dependent glucose transporter 1	518	56218	5.27	12	Apical cell membrane	NA	May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.	NA	Belongs to the major facilitator superfamily.	Cellular hexose transport	PE1	6
+NX_Q5TF58	Intermediate filament family orphan 2	517	57328	4.86	0	Nucleoplasm;Cell membrane	NA	NA	NA	Belongs to the intermediate filament family.	NA	PE1	1
+NX_Q5TFE4	5'-nucleotidase domain-containing protein 1	455	51845	5.94	0	NA	NA	NA	NA	Belongs to the 5'(3')-deoxyribonucleotidase family.	NA	PE1	6
+NX_Q5TFG8	Zinc finger C2HC domain-containing protein 1B	222	24665	10.32	0	NA	NA	NA	NA	Belongs to the ZC2HC1 family.	NA	PE1	6
+NX_Q5TFQ8	Signal-regulatory protein beta-1 isoform 3	398	43359	7.7	1	Membrane	NA	Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.	NA	NA	Osteoclast differentiation	PE1	20
+NX_Q5TG30	Rho GTPase-activating protein 40	622	68908	7.7	0	Nucleoplasm;Cytosol;Centrosome;Cell membrane	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	NA	NA	Rho GTPase cycle	PE2	20
+NX_Q5TG53	Putative uncharacterized protein SERTAD4-AS1	156	16212	10.6	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q5TG92	Putative uncharacterized protein C1orf195	126	13826	10.19	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q5TGI0	Failed axon connections homolog	409	46843	5.34	1	Membrane;Nucleoplasm	NA	May play a role in axonal development.	NA	Belongs to the FAX family.	NA	PE1	6
+NX_Q5TGI4	Sterile alpha motif domain-containing protein 5	173	19231	9.19	0	Cytoplasmic vesicle;Cytoplasm	NA	NA	NA	NA	NA	PE1	6
+NX_Q5TGJ6	Hepatoma-derived growth factor-like protein 1	251	27234	4.5	0	NA	NA	NA	NA	Belongs to the HDGF family.	NA	PE1	6
+NX_Q5TGL8	PX domain-containing protein 1	231	26560	4.94	0	Cell membrane	NA	NA	NA	NA	NA	PE1	6
+NX_Q5TGP6	Maestro heat-like repeat-containing protein family member 9	573	65050	5.94	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q5TGS1	Transcription factor HES-3	186	19968	9.74	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor of genes that require a bHLH protein for their transcription.	NA	NA	NA	PE2	1
+NX_Q5TGU0	Translocator protein 2	170	19129	8.48	5	Endoplasmic reticulum membrane	NA	Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocyte maturation.	NA	Belongs to the TspO/BZRP family.	NA	PE1	6
+NX_Q5TGY1	Transmembrane and coiled-coil domain-containing protein 4	634	67910	5.59	3	Membrane;Endoplasmic reticulum	NA	NA	NA	Belongs to the TMCO4 family.	NA	PE1	1
+NX_Q5TGY3	AT-hook DNA-binding motif-containing protein 1	1603	168349	9.21	0	Nucleoplasm	Mental retardation, autosomal dominant 25	NA	NA	NA	NA	PE1	1
+NX_Q5TGZ0	MICOS complex subunit MIC10	78	8808	8.69	1	Mitochondrion inner membrane;Mitochondrion	NA	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	NA	Belongs to the MICOS complex subunit Mic10 family.	Cristae formation	PE1	1
+NX_Q5TH69	Brefeldin A-inhibited guanine nucleotide-exchange protein 3	2177	240652	5.54	1	Cytoplasm;Secretory vesicle membrane;Secretory vesicle	NA	Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786).	NA	NA	NA	PE1	6
+NX_Q5TH74	O(6)-methylguanine-induced apoptosis 2	334	36786	9.79	0	Nucleoplasm;Cytoplasm;Nucleus	NA	May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.	NA	Belongs to the STPG1 family.	NA	PE1	1
+NX_Q5THJ4	Vacuolar protein sorting-associated protein 13D	4388	491916	6.15	0	Cytoplasmic vesicle;Nucleoplasm;Cytosol	Spinocerebellar ataxia, autosomal recessive 4	Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis.	NA	Belongs to the VPS13 family.	NA	PE1	1
+NX_Q5THK1	Protein PRR14L	2151	237300	5.93	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	22
+NX_Q5THR3	EF-hand calcium-binding domain-containing protein 6	1501	172930	8.67	0	Nucleoplasm;Nucleus	NA	Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.	NA	NA	NA	PE1	22
+NX_Q5TI25	Neuroblastoma breakpoint family member 14	921	105853	4.5	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE2	1
+NX_Q5TIA1	Meiosis inhibitor protein 1	1274	141161	6.24	0	NA	NA	Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity).	NA	NA	NA	PE1	22
+NX_Q5TID7	Coiled-coil domain-containing protein 181	509	60103	5.7	0	Flagellum;Nucleus speckle;Cytoskeleton	NA	Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.	NA	Belongs to the CCDC181 family.	NA	PE1	1
+NX_Q5TIE3	von Willebrand factor A domain-containing protein 5B1	1220	133802	8.45	0	Cytosol;Mitochondrion;Secreted;Cell membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q5TKA1	Protein lin-9 homolog	542	61946	9.17	0	Nucleoplasm	NA	Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.	NA	Belongs to the lin-9 family.	G0 and Early G1;G1/S-Specific Transcription;Polo-like kinase mediated events;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	PE1	1
+NX_Q5TYM5	Protein FAM72A	149	16619	5.54	0	Cytoplasm;Mitochondrion	NA	May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation.	NA	Belongs to the FAM72 family.	NA	PE1	1
+NX_Q5TYW1	Zinc finger protein 658	1059	122274	8.63	0	Nucleus	NA	Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	9
+NX_Q5TYW2	Ankyrin repeat domain-containing protein 20A1	823	94048	7.97	0	Cell membrane	NA	NA	NA	NA	NA	PE2	9
+NX_Q5TYX0	PRAME family member 5	476	54886	8.53	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_Q5TZ20	Olfactory receptor 2G6	316	34890	8.85	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q5TZA2	Rootletin	2017	228523	5.45	0	Centriole;Centrosome;Cilium basal body;Cell membrane	NA	Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858).	Phosphorylated by NEK2 which may regulate its association with centrosomes.;CROCC is phosphorylated by NEK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the rootletin family.	NA	PE1	1
+NX_Q5TZF3	Ankyrin repeat domain-containing protein 45	266	29977	4.62	0	Cytosol;Centrosome;Cell membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q5TZJ5	Spermatogenesis-associated protein 31A1	1347	148561	9.07	1	Membrane	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA31 family.	NA	PE1	9
+NX_Q5TZK3	Protein FAM74A4/A6	123	14773	10.66	0	NA	NA	NA	NA	Belongs to the FAM74 family.	NA	PE1	9
+NX_Q5U3C3	Transmembrane protein 164	297	33508	8.41	7	Membrane;Cytoplasmic vesicle;Cell junction	NA	NA	NA	Belongs to the TMEM164 family.	NA	PE1	X
+NX_Q5U4N7	Protein GDF5OS, mitochondrial	250	28211	12.03	0	Mitochondrion	NA	NA	NA	NA	NA	PE2	20
+NX_Q5U4P2	Aspartate beta-hydroxylase domain-containing protein 1	390	41128	8.94	1	Membrane	NA	NA	NA	Belongs to the aspartyl/asparaginyl beta-hydroxylase family.	NA	PE1	16
+NX_Q5U5Q3	RNA-binding E3 ubiquitin-protein ligase MEX3C	659	69366	4.93	0	Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	18
+NX_Q5U5R9	Probable E3 ubiquitin-protein ligase HECTD2	776	88122	8.42	0	Nucleoplasm	NA	Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	10
+NX_Q5U5X0	Complex III assembly factor LYRM7	104	11955	9.67	0	Mitochondrion matrix	Mitochondrial complex III deficiency, nuclear 8	Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.	NA	Belongs to the complex I LYR family.	NA	PE1	5
+NX_Q5U5X8	Protein FAM222A	452	46792	9.2	0	Nucleoplasm;Mitochondrion;Focal adhesion;Cell membrane	NA	NA	NA	Belongs to the FAM222 family.	NA	PE1	12
+NX_Q5U5Z8	Cytosolic carboxypeptidase 2	902	104194	9.14	0	Cytosol;Cilium basal body;Centriole	NA	Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.	NA	Belongs to the peptidase M14 family.	Carboxyterminal post-translational modifications of tubulin	PE1	11
+NX_Q5U623	Activating transcription factor 7-interacting protein 2	682	75764	7.96	0	Nucleus	NA	Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable).	NA	Belongs to the MCAF family.	NA	PE1	16
+NX_Q5U649	Uncharacterized protein C12orf60	245	27626	7.73	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	12
+NX_Q5U651	Ras-interacting protein 1	963	103457	8.17	0	Perinuclear region;Golgi stack	NA	Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.	NA	NA	NA	PE1	19
+NX_Q5UAW9	G-protein coupled receptor 157	335	36623	9.27	7	Cilium membrane;Cell junction;Nucleolus;Cell membrane	NA	Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger.	NA	Belongs to the G-protein coupled receptor 2 family.	NA	PE1	1
+NX_Q5UCC4	ER membrane protein complex subunit 10	262	27347	5.78	1	Membrane;Secreted	NA	Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.	Glycosylated.	Belongs to the EMC10 family.	NA	PE1	19
+NX_Q5UE93	Phosphoinositide 3-kinase regulatory subunit 6	754	84258	7.58	0	Golgi apparatus;Cytoplasm;Cell membrane;Nucleoplasm;Cytosol	NA	Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.	NA	NA	Synthesis of PIPs at the plasma membrane;GPVI-mediated activation cascade;G beta:gamma signalling through PI3Kgamma	PE1	17
+NX_Q5UIP0	Telomere-associated protein RIF1	2472	274466	5.39	0	Cell membrane;Chromosome;Nucleoplasm;Telomere;Spindle;Nucleus	NA	Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity).	NA	Belongs to the RIF1 family.	Nonhomologous End-Joining (NHEJ)	PE1	2
+NX_Q5VIR6	Vacuolar protein sorting-associated protein 53 homolog	699	79653	5.74	0	Recycling endosome;trans-Golgi network membrane;Endosome membrane	Pontocerebellar hypoplasia 2E	Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).	NA	Belongs to the VPS53 family.	Retrograde transport at the Trans-Golgi-Network	PE1	17
+NX_Q5VIY5	Zinc finger protein 468	522	60573	9.1	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q5VSD8	Putative uncharacterized protein LOC401522	79	8201	9.82	0	NA	NA	NA	NA	NA	NA	PE4	9
+NX_Q5VSG8	Glycoprotein endo-alpha-1,2-mannosidase-like protein	457	51317	6.47	1	Golgi apparatus;Golgi apparatus membrane	NA	NA	NA	Belongs to the glycosyl hydrolase 99 family.	NA	PE1	1
+NX_Q5VSL9	Striatin-interacting protein 1	837	95576	5.92	0	Cytoplasm;Cytosol	NA	Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.	NA	Belongs to the STRIP family.	NA	PE1	1
+NX_Q5VSP4	Putative lipocalin 1-like protein 1	162	17918	4.93	0	Secreted	NA	May bind a variety of ligands including lipids.	NA	Belongs to the calycin superfamily. Lipocalin family.	NA	PE5	9
+NX_Q5VSR9	Sperm protein associated with the nucleus on the X chromosome N1	72	8263	5.79	0	NA	NA	NA	NA	Belongs to the SPAN-X family.	NA	PE2	X
+NX_Q5VST6	Alpha/beta hydrolase domain-containing protein 17B	288	32215	5.89	0	Postsynaptic density;Dendritic spine;Recycling endosome membrane;Cell membrane	NA	Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913).	Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.	Belongs to the AB hydrolase superfamily. ABHD17 family.	NA	PE1	9
+NX_Q5VST9	Obscurin	7968	868484	5.69	0	Cell membrane;M line;Cytosol;Z line;Sarcolemma;Nucleus	NA	Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662).	Autophosphorylated by protein kinase domains 1 and 2.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	1
+NX_Q5VSY0	G kinase-anchoring protein 1	366	42078	8.89	0	Golgi apparatus;Cytosol;Centriolar satellite	NA	Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.	GKAP1 is phosphorylated by PRKG1	Belongs to the GKAP1 family.	NA	PE1	9
+NX_Q5VT03	NUT family member 2D	806	86276	6.98	0	NA	NA	NA	NA	Belongs to the NUT family.	NA	PE2	10
+NX_Q5VT06	Centrosome-associated protein 350	3117	350930	5.95	0	Centriole;Cilium basal body;Centrosome;Spindle;Nucleus	NA	Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385).	Phosphorylated during mitosis.	NA	NA	PE1	1
+NX_Q5VT25	Serine/threonine-protein kinase MRCK alpha	1732	197307	6.16	0	Cytoplasm;Lamellipodium;Cytoskeleton	NA	Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.	NA	PE1	1
+NX_Q5VT28	Protein FAM27A/B/C	67	7388	7.82	0	NA	NA	NA	NA	Belongs to the FAM27 family.	NA	PE3	9
+NX_Q5VT33	Putative uncharacterized protein encoded by LINC01545	79	9515	10.54	0	NA	NA	NA	NA	NA	NA	PE4	X
+NX_Q5VT40	Protein FAM78B	261	29835	9.46	0	Golgi apparatus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the FAM78 family.	NA	PE2	1
+NX_Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	1461	156020	6.97	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	NA	RNA polymerase II transcribes snRNA genes	PE1	1
+NX_Q5VT66	Mitochondrial amidoxime-reducing component 1	337	37499	9.12	1	Mitochondrion outer membrane;Membrane;Mitochondrion	NA	As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.	NA	NA	Phase I - Functionalization of compounds	PE1	1
+NX_Q5VT79	Annexin A8-like protein 1	327	36879	5.56	0	NA	NA	NA	NA	Belongs to the annexin family.	NA	PE1	10
+NX_Q5VT97	Rho GTPase-activating protein SYDE2	1194	133230	8.83	0	Golgi apparatus;Nucleolus	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	NA	NA	Rho GTPase cycle	PE1	1
+NX_Q5VT98	PRAME family member 20	475	54784	8.45	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_Q5VT99	Leucine-rich repeat-containing protein 38	294	32082	4.82	1	Cell membrane	NA	Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium.	NA	NA	NA	PE1	1
+NX_Q5VTA0	PRAME family member 17	474	54769	8.41	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_Q5VTB9	E3 ubiquitin-protein ligase RNF220	566	62765	5.7	0	Cytoplasm	NA	E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).	Auto-ubiquitinated; leads to proteasomal degradation.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	1
+NX_Q5VTD9	Zinc finger protein Gfi-1b	330	37492	9.25	0	Nucleoplasm;Nucleus	Bleeding disorder, platelet-type 17	Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.	Methylation at Lys-8 in the SNAG domain seems required for the recruitment of the corepressor complex.	NA	NA	PE1	9
+NX_Q5VTE0	Putative elongation factor 1-alpha-like 3	462	50185	9.15	0	Cytoplasm	NA	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Eukaryotic Translation Elongation	PE5	9
+NX_Q5VTE6	Protein angel homolog 2	544	62339	8	0	Nucleoplasm;Mitochondrion;Nucleus	NA	NA	NA	Belongs to the CCR4/nocturin family.	NA	PE1	1
+NX_Q5VTH2	Protein Flattop	177	19293	10.09	0	Apical cell membrane;Cilium;Cilium basal body	NA	Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.	NA	Belongs to the Flattop family.	NA	PE1	1
+NX_Q5VTH9	WD repeat-containing protein 78	848	94573	5.53	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q5VTJ3	Kelch domain-containing protein 7A	777	84479	7.93	1	Membrane;Nucleus speckle	NA	NA	NA	NA	NA	PE1	1
+NX_Q5VTL7	Fibronectin type III domain-containing protein 7	733	78236	5.46	0	Nucleoplasm;Secreted;Cytoskeleton	NA	NA	NA	NA	NA	PE1	1
+NX_Q5VTL8	Pre-mRNA-splicing factor 38B	546	64468	10.54	0	Nucleus	NA	May be required for pre-mRNA splicing.	NA	Belongs to the PRP38 family.	Spliceosome	PE1	1
+NX_Q5VTM2	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9	703	77972	8.14	0	NA	NA	Putative GTPase-activating protein.	NA	Belongs to the centaurin gamma-like family.	NA	PE2	10
+NX_Q5VTQ0	Tetratricopeptide repeat protein 39B	682	76956	7.16	0	Endoplasmic reticulum	NA	Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3).	NA	Belongs to the TTC39 family.	NA	PE1	9
+NX_Q5VTR2	E3 ubiquitin-protein ligase BRE1A	975	113662	5.73	0	Nucleoplasm;Nucleus	NA	Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.	NA	Belongs to the BRE1 family.	Protein modification; protein ubiquitination.;E3 ubiquitin ligases ubiquitinate target proteins	PE1	9
+NX_Q5VTT2	Protein C9orf135	229	26445	6.75	1	Cytoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	9
+NX_Q5VTT5	Myomesin-3	1437	162189	5.89	0	Golgi apparatus;Cytoplasmic vesicle;M line;Cytoskeleton	NA	May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.	NA	NA	NA	PE1	1
+NX_Q5VTU8	ATP synthase subunit epsilon-like protein, mitochondrial	51	5807	10.15	0	Mitochondrion inner membrane	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).	NA	Belongs to the eukaryotic ATPase epsilon family.	NA	PE1	13
+NX_Q5VTY9	Protein-cysteine N-palmitoyltransferase HHAT	493	57313	6.9	10	Golgi apparatus;Endoplasmic reticulum membrane	NA	Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP.	NA	Belongs to the membrane-bound acyltransferase family. HHAT subfamily.	Hedgehog ligand biogenesis;HHAT G278V abrogates palmitoylation of Hh-Np	PE1	1
+NX_Q5VU36	Spermatogenesis-associated protein 31A5	1347	148687	9	1	Membrane	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA31 family.	NA	PE2	9
+NX_Q5VU43	Myomegalin	2346	265103	5.35	0	Golgi apparatus;Centrosome;Cytoskeleton	NA	Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity).;Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697).	NA	NA	NA	PE1	1
+NX_Q5VU57	Cytosolic carboxypeptidase 6	503	58230	8.66	0	Golgi apparatus;Cytosol;Cilium basal body;Centriole	NA	Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.	NA	Belongs to the peptidase M14 family.	Carboxyterminal post-translational modifications of tubulin	PE1	1
+NX_Q5VU65	Nuclear pore membrane glycoprotein 210-like	1888	210605	7.15	1	Membrane;Nucleus	NA	NA	NA	Belongs to the NUP210 family.	RNA transport	PE1	1
+NX_Q5VU69	Uncharacterized protein C1orf189	101	12131	9.72	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q5VU92	DDB1- and CUL4-associated factor 12-like protein 1	463	51201	8.84	0	NA	NA	NA	NA	Belongs to the WD repeat DCAF12 family.	NA	PE1	X
+NX_Q5VU97	VWFA and cache domain-containing protein 1	1274	142290	5.97	1	Membrane;Nucleoplasm;Nucleolus	NA	May regulate voltage-dependent calcium channels.	NA	Belongs to the calcium channel subunit alpha-2/delta family.	NA	PE1	1
+NX_Q5VUA4	Zinc finger protein 318	2279	251112	6.78	0	Nucleoplasm;Cytosol;Nucleus	NA	Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.;Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.	NA	NA	NA	PE1	6
+NX_Q5VUB5	Protein FAM171A1	890	97854	6.12	1	Nucleoplasm;Cell membrane	NA	Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation.	NA	Belongs to the FAM171 family.	NA	PE1	10
+NX_Q5VUD6	Divergent protein kinase domain 1B	431	48583	9	1	Nucleoplasm;Endoplasmic reticulum membrane;Nucleus;Cytoplasmic vesicle	NA	NA	Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.	Belongs to the DIPK family.	NA	PE1	9
+NX_Q5VUE5	Uncharacterized protein C1orf53	145	15483	9.03	0	Cytoplasmic vesicle;Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q5VUG0	Scm-like with four MBT domains protein 2	894	100563	6.14	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Transcriptional repressor of HOXB13 gene.	NA	NA	NA	PE1	10
+NX_Q5VUJ5	Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7	663	73211	6.25	0	NA	NA	Putative GTPase-activating protein.	NA	Belongs to the centaurin gamma-like family.	NA	PE5	10
+NX_Q5VUJ6	Leucine-rich repeat and calponin homology domain-containing protein 2	765	84588	6.11	0	Nucleolus;Cell membrane	NA	May play a role in the organization of the cytoskeleton.	NA	NA	NA	PE1	X
+NX_Q5VUJ9	Dynein regulatory complex protein 8	269	29714	8.92	0	Flagellum axoneme;Cytosol;Cell membrane	NA	Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.	NA	Belongs to the DRC8 family.	NA	PE1	1
+NX_Q5VUM1	Succinate dehydrogenase assembly factor 4, mitochondrial	108	12213	9.43	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	NA	Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity).	NA	Belongs to the SDHAF4 family.	NA	PE1	6
+NX_Q5VUR7	Ankyrin repeat domain-containing protein 20A3	823	94108	8.12	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q5VUY0	Arylacetamide deacetylase-like 3	407	46155	7.54	0	NA	NA	NA	NA	Belongs to the 'GDXG' lipolytic enzyme family.	NA	PE2	1
+NX_Q5VUY2	Arylacetamide deacetylase-like 4	407	46082	8.54	1	Membrane	NA	NA	NA	Belongs to the 'GDXG' lipolytic enzyme family.	NA	PE2	1
+NX_Q5VV11	Putative UPF0633 protein ENSP00000303136	94	10769	11.91	0	NA	NA	NA	NA	Belongs to the UPF0633 family.	NA	PE5	9
+NX_Q5VV16	Forkhead box protein D4-like 5	416	45780	9.58	0	Nucleus	NA	NA	NA	NA	NA	PE2	9
+NX_Q5VV17	OTU domain-containing protein 1	481	51063	5.68	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin.	NA	NA	NA	PE1	10
+NX_Q5VV41	Rho guanine nucleotide exchange factor 16	709	80105	6.9	0	Cytoplasm	NA	Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	1
+NX_Q5VV42	Threonylcarbamoyladenosine tRNA methylthiotransferase	579	65111	7.2	1	Cytoplasmic vesicle;Endoplasmic reticulum membrane	Diabetes mellitus, non-insulin-dependent	Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.	NA	Belongs to the methylthiotransferase family. CDKAL1 subfamily.	tRNA modification in the nucleus and cytosol	PE1	6
+NX_Q5VV43	Dyslexia-associated protein KIAA0319	1072	117763	5.34	1	Early endosome membrane;Cytoplasmic vesicle;Cell membrane	Dyslexia 2	Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites.	N-glycosylated.;O-glycosylated.;Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus.	NA	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	6
+NX_Q5VV52	Zinc finger protein 691	315	35810	7.9	0	Nucleoplasm;Nucleus;Nucleolus;Cytoplasmic vesicle	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q5VV63	Attractin-like protein 1	1379	152639	7.31	1	Membrane;Nucleoplasm;Mitochondrion	NA	May play a role in melanocortin signaling pathways that regulate energy homeostasis.	NA	NA	NA	PE1	10
+NX_Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	1664	177544	6.11	0	Nucleoplasm;Nucleus	NA	Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.	NA	NA	Transcriptional activation of mitochondrial biogenesis	PE1	10
+NX_Q5VVB8	Transmembrane protein 244	128	14657	5.82	3	Membrane	NA	NA	NA	NA	NA	PE2	6
+NX_Q5VVC0	Uncharacterized protein C1orf146	180	20418	9.03	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q5VVH5	Interleukin-1 receptor-associated kinase 1-binding protein 1	260	29106	9.07	0	Cytoplasmic vesicle;Cytoplasm;Nucleus	NA	Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).	Phosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity).	Belongs to the IRAK1BP1 family.	NA	PE1	6
+NX_Q5VVJ2	Histone H2A deubiquitinase MYSM1	828	95032	5.4	0	Nucleoplasm;Nucleus;Cell membrane	Bone marrow failure syndrome 4	Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis and lymphocyte differentiation (PubMed:28115216, PubMed:26220525).	NA	Belongs to the peptidase M67A family. MYSM1 subfamily.	Metalloprotease DUBs	PE1	1
+NX_Q5VVM6	Coiled-coil domain-containing protein 30	783	91333	5.57	0	NA	NA	NA	NA	Belongs to the prefoldin subunit beta family.	NA	PE1	1
+NX_Q5VVP1	Spermatogenesis-associated protein 31A6	1343	147818	8.99	1	Membrane	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA31 family.	NA	PE2	9
+NX_Q5VVQ6	Ubiquitin thioesterase OTU1	348	38322	5.77	0	Nucleoplasm;Cytoplasm;Cytosol;Cell membrane	NA	Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622).	NA	NA	Protein processing in endoplasmic reticulum;Ovarian tumor domain proteases	PE1	1
+NX_Q5VVS0	Putative uncharacterized protein C1orf140	124	13926	6.89	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q5VVW2	GTPase-activating Rap/Ran-GAP domain-like protein 3	1013	112852	7.57	0	Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	Belongs to the GARNL3 family.	NA	PE1	9
+NX_Q5VVX9	Ubiquitin-conjugating enzyme E2 U	321	37741	5.06	0	NA	NA	Catalyzes the covalent attachment of ubiquitin to other proteins.	Autoubiquitinated in vitro in the presence of UBR5.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	1
+NX_Q5VVY1	Alpha N-terminal protein methyltransferase 1B	283	32400	6.51	0	Nucleus	NA	Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.	NA	Belongs to the methyltransferase superfamily. NTM1 family.	NA	PE1	1
+NX_Q5VW00	DDB1- and CUL4-associated factor 12-like protein 2	463	50803	9.36	0	NA	NA	NA	NA	Belongs to the WD repeat DCAF12 family.	NA	PE1	X
+NX_Q5VW22	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6	663	73127	6.41	0	NA	NA	Putative GTPase-activating protein.	NA	Belongs to the centaurin gamma-like family.	NA	PE2	10
+NX_Q5VW32	BRO1 domain-containing protein BROX	411	46476	7.55	0	Membrane;Nucleoplasm;Golgi apparatus;Cytosol	NA	NA	NA	Belongs to the BROX family.	NA	PE1	1
+NX_Q5VW36	Focadhesin	1801	200072	6.17	3	Membrane;Mitochondrion;Focal adhesion	NA	Potential tumor suppressor in gliomas.	NA	NA	NA	PE1	9
+NX_Q5VW38	Protein GPR107	600	66990	6.77	7	Golgi apparatus;Nucleoplasm;trans-Golgi network membrane;Cell membrane	NA	Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity).;(Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum.	Cleaved by FURIN to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.	Belongs to the LU7TM family.	NA	PE1	9
+NX_Q5VWC8	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4	232	27520	8.76	6	Endoplasmic reticulum membrane	NA	Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.	NA	Belongs to the very long-chain fatty acids dehydratase HACD family.	Lipid metabolism; fatty acid biosynthesis.;Synthesis of very long-chain fatty acyl-CoAs	PE1	9
+NX_Q5VWG9	Transcription initiation factor TFIID subunit 3	929	103582	9.13	0	Nucleoplasm;Nucleus;Nucleus membrane	NA	Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.	NA	Belongs to the TAF3 family.	Basal transcription factors;Herpes simplex infection;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation	PE1	10
+NX_Q5VWI1	Transcription elongation regulator 1-like protein	586	65660	9.84	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_Q5VWJ9	Sorting nexin-30	437	49677	5.21	0	Nucleoplasm;Cytosol;Nucleolus	NA	May be involved in several stages of intracellular trafficking.	NA	Belongs to the sorting nexin family.	NA	PE1	9
+NX_Q5VWK0	Neuroblastoma breakpoint family member 6	638	72239	4.84	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE2	1
+NX_Q5VWK5	Interleukin-23 receptor	629	71722	5.32	1	Cell membrane	Inflammatory bowel disease 17	Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.	Phosphorylated in response to IL23.	Belongs to the type I cytokine receptor family. Type 2 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-4 and Interleukin-13 signaling;Interleukin-23 signaling	PE1	1
+NX_Q5VWM3	PRAME family member 18	479	55334	8.31	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_Q5VWM4	PRAME family member 8	474	53655	5.99	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_Q5VWM5	PRAME family member 9/15	478	55420	8.82	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_Q5VWM6	Putative PRAME family member 13	474	54914	8.85	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE5	1
+NX_Q5VWN6	Protein TASOR 2	2430	268843	5.61	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the TASOR family.	NA	PE1	10
+NX_Q5VWP2	Terminal nucleotidyltransferase 5C	391	44944	5.45	0	Nucleoplasm;Cytoplasm;Nucleus	NA	(Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.;Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.	NA	Belongs to the TENT family.	NA	PE1	1
+NX_Q5VWP3	Muscular LMNA-interacting protein	458	50429	5.96	0	Nucleoplasm;Nucleus envelope;PML body;Sarcolemma;Nucleus	NA	Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD.	NA	NA	NA	PE1	6
+NX_Q5VWQ0	Lysine-specific demethylase 9	802	90072	8.85	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture.	Phosphorylated by PKA.	Belongs to the round spermatid basic protein 1 family.	NA	PE1	1
+NX_Q5VWQ8	Disabled homolog 2-interacting protein	1189	131625	8.92	0	Membrane;Cytoplasm;Dendrite;Cell membrane	NA	Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively.	In response to TNF-alpha-induction, phosphorylated at Ser-728; phosphorylation leads to a conformational change, and thus, increases its association with 14-3-3 proteins, MAP3K5, RIPK1 and TRAF2 in endothelial cells; also stimulates regulatory p85 subunit sequestring and PI3K-p85 complex activity inhibition.	NA	Regulation of RAS by GAPs;Signaling by RAS mutants	PE1	9
+NX_Q5VWT5	FYN-binding protein 2	728	82070	8.58	0	Membrane raft	NA	Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation (PubMed:27335501).	Phosphorylation is required for its function in T-cell activation.	NA	NA	PE1	1
+NX_Q5VWW1	Complement C1q-like protein 3	255	26719	6.29	0	Secreted	NA	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).	NA	NA	NA	PE1	10
+NX_Q5VWX1	KH domain-containing, RNA-binding, signal transduction-associated protein 2	349	38927	5.94	0	Nucleus	NA	RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.	Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis (By similarity).;Methylated.;KHDRBS2 is phosphorylated by PTK6	Belongs to the KHDRBS family.	PTK6 Regulates Proteins Involved in RNA Processing	PE1	6
+NX_Q5VWZ2	Lysophospholipase-like protein 1	237	26316	7.71	0	Cytosol	NA	Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.	NA	Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	NA	PE1	1
+NX_Q5VX52	Spermatogenesis-associated protein 1	459	52946	8.93	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q5VX71	Sushi domain-containing protein 4	490	53778	4.78	1	Membrane;Cytoplasmic vesicle;Secreted	NA	Acts as complement inhibitor by disrupting the formation of the classical C3 convertase.;Inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.	NA	NA	NA	PE2	1
+NX_Q5VXD3	Sterile alpha motif domain-containing protein 13	122	13570	4.98	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	1
+NX_Q5VXH4	PRAME family member 6	476	54852	8.54	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_Q5VXH5	PRAME family member 7	474	53627	5.99	0	NA	NA	NA	NA	Belongs to the PRAME family.	NA	PE2	1
+NX_Q5VXI9	Lipase member N	398	45534	6.35	0	Secreted	Ichthyosis, congenital, autosomal recessive 8	Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Formation of the cornified envelope	PE2	10
+NX_Q5VXJ0	Lipase member K	399	45563	8.39	0	Secreted	NA	Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Formation of the cornified envelope	PE2	10
+NX_Q5VXM1	CUB domain-containing protein 2	449	48752	5.81	0	Secreted	NA	NA	NA	NA	NA	PE2	1
+NX_Q5VXT5	Synaptophysin-like protein 2	272	30156	5.4	4	Membrane;Cytosol;Cell membrane	NA	Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.	NA	Belongs to the synaptophysin/synaptobrevin family.	NA	PE1	1
+NX_Q5VXU1	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2	208	23831	4.94	4	Cytosol;Cell membrane	NA	NA	NA	Belongs to the NKAIN family.	NA	PE2	6
+NX_Q5VXU3	Cysteine-rich hydrophobic domain-containing protein 1	224	25616	4.51	0	Cytoplasmic vesicle;Cytosol;Nucleus speckle;Cell membrane	NA	NA	Palmitoylated.	Belongs to the CHIC family.	NA	PE1	X
+NX_Q5VXU9	Protein shortage in chiasmata 1 ortholog	1444	165202	5.1	0	Cytoplasmic vesicle;Cytosol;Chromosome	NA	ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (PubMed:29742103). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (PubMed:29742103).	NA	Belongs to the XPF family. Highly divergent.	NA	PE1	9
+NX_Q5VY09	Immediate early response gene 5 protein	327	33704	4.91	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	NA	Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193).	NA	Belongs to the IER family.	NA	PE1	1
+NX_Q5VY43	Platelet endothelial aggregation receptor 1	1037	110666	6.4	1	Nucleoplasm;Cell junction;Centrosome;Cell membrane	NA	When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.	Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.	Belongs to the MEGF family.	NA	PE1	1
+NX_Q5VY80	UL16-binding protein 6	246	27509	5.96	0	Endoplasmic reticulum;Cell membrane	NA	Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.	NA	Belongs to the MHC class I family.	Natural killer cell mediated cytotoxicity;Post-translational modification: synthesis of GPI-anchored proteins	PE1	6
+NX_Q5VYJ5	MAM and LDL-receptor class A domain-containing protein 1	2156	241008	5.04	1	Golgi apparatus;Cytoplasmic vesicle membrane	NA	Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.	NA	NA	NA	PE1	10
+NX_Q5VYK3	Proteasome adapter and scaffold protein ECM29	1845	204291	6.74	0	Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Multivesicular body;Endoplasmic reticulum;Nucleoplasm;Endosome;Centrosome;Cytoplasmic vesicle;Nucleus	NA	Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity).	NA	Belongs to the ECM29 family.	NA	PE1	9
+NX_Q5VYM1	Uncharacterized protein C9orf131	1079	117724	7	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	9
+NX_Q5VYP0	Spermatogenesis-associated protein 31A3	1347	148706	8.99	1	Membrane	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA31 family.	NA	PE2	9
+NX_Q5VYS4	Mesenteric estrogen-dependent adipogenesis protein	303	34190	6.06	0	Cytoplasm	NA	Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.	NA	NA	NA	PE1	13
+NX_Q5VYS8	Terminal uridylyltransferase 7	1495	171229	6.4	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:19703396, PubMed:22898984, PubMed:18172165, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351).	NA	Belongs to the DNA polymerase type-B-like family.	Deadenylation of mRNA	PE1	9
+NX_Q5VYV0	Forkhead box protein B2	432	45581	9.55	0	Nucleus	NA	Transcription factor.	NA	NA	NA	PE2	9
+NX_Q5VYV7	Protein SLX4IP	408	45552	9.5	0	Cytosol	NA	NA	NA	Belongs to the SLX4IP family.	NA	PE1	20
+NX_Q5VYX0	Renalase	342	37847	6.06	0	Secreted	NA	Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.	NA	Belongs to the renalase family.	Nicotinamide salvaging	PE1	10
+NX_Q5VYY1	Ankyrin repeat domain-containing protein 22	191	21849	9.07	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	10
+NX_Q5VYY2	Lipase member M	423	48233	6.64	0	Secreted	NA	Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Formation of the cornified envelope	PE2	10
+NX_Q5VZ03	Nucleoredoxin-like protein 2	156	17614	6.9	0	Cytosol	NA	May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons.	NA	Belongs to the nucleoredoxin family.	NA	PE2	9
+NX_Q5VZ18	SH2 domain-containing adapter protein E	495	53950	9.23	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q5VZ19	Tudor domain-containing protein 10	366	40941	8.1	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	1
+NX_Q5VZ46	Uncharacterized protein KIAA1614	1190	126604	9.1	0	Cytoplasmic vesicle;Nucleus membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q5VZ52	MORN repeat-containing protein 5	161	18731	5.58	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_Q5VZ66	Janus kinase and microtubule-interacting protein 3	844	98529	5.53	0	Golgi apparatus	NA	NA	NA	Belongs to the JAKMIP family.	NA	PE1	10
+NX_Q5VZ72	Izumo sperm-egg fusion protein 3	239	27768	8.62	1	Cell membrane	NA	NA	NA	Belongs to the Izumo family.	Acrosome Reaction and Sperm:Oocyte Membrane Binding	PE1	9
+NX_Q5VZ89	DENN domain-containing protein 4C	1909	212711	6.39	0	Golgi apparatus;Cell membrane;Cytoplasmic vesicle membrane;Cytoplasmic vesicle;Cytosol	NA	Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.	Phosphorylated in response to insulin.	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	9
+NX_Q5VZB9	Doublesex- and mab-3-related transcription factor A1	504	53125	9.15	0	Cytoplasmic vesicle;Nucleus	NA	NA	NA	Belongs to the DMRT family.	NA	PE1	9
+NX_Q5VZE5	N-alpha-acetyltransferase 35, NatC auxiliary subunit	725	83639	6.6	0	Cytoplasm;Cytoplasmic vesicle	NA	Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.	NA	Belongs to the MAK10 family.	Retrograde transport at the Trans-Golgi-Network	PE1	9
+NX_Q5VZF2	Muscleblind-like protein 2	373	40518	8.77	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).	NA	Belongs to the muscleblind family.	NA	PE1	13
+NX_Q5VZI3	Transmembrane protein 268	342	37569	5.19	2	Membrane;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	9
+NX_Q5VZK9	F-actin-uncapping protein LRRC16A	1371	151557	8.02	0	Cytoplasm;Cell membrane;Lamellipodium;Cytosol;Cytoskeleton	NA	Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667).	NA	Belongs to the CARMIL family.	Factors involved in megakaryocyte development and platelet production	PE1	6
+NX_Q5VZL5	Zinc finger MYM-type protein 4	1548	172788	6.46	0	Nucleoplasm;Cytosol;Nucleolus	NA	Plays a role in the regulation of cell morphology and cytoskeletal organization.	NA	NA	NA	PE1	1
+NX_Q5VZM2	Ras-related GTP-binding protein B	374	43250	5.85	0	Cytoplasm;Lysosome	NA	Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.	NA	Belongs to the GTR/RAG GTP-binding protein family.	Macroautophagy;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;mTOR signalling;mTORC1-mediated signalling;Regulation of PTEN gene transcription	PE1	X
+NX_Q5VZP5	Inactive dual specificity phosphatase 27	1158	130176	5.1	0	Nucleoplasm;Sarcomere	NA	May be required for myofiber maturation.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	1
+NX_Q5VZQ5	Testis-expressed protein 36	186	21545	9.79	0	NA	NA	NA	NA	NA	NA	PE1	10
+NX_Q5VZR2	NUT family member 2G	741	79011	8.51	0	NA	NA	NA	NA	Belongs to the NUT family.	NA	PE2	9
+NX_Q5VZR4	Hippocampus abundant transcript-like protein 2	150	16372	7.77	3	Membrane	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE2	9
+NX_Q5VZT2	Putative uncharacterized protein C10orf113	155	17689	10.01	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_Q5VZV1	Protein-lysine methyltransferase METTL21C	264	29565	4.85	0	Nucleus	NA	Protein-lysine methyltransferase.	NA	Belongs to the methyltransferase superfamily. METTL21 family.	NA	PE1	13
+NX_Q5VZY2	Phospholipid phosphatase 4	271	30395	8.5	6	Membrane;Nucleoplasm;Nucleolus	NA	Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.	NA	Belongs to the PA-phosphatase related phosphoesterase family.	Role of phospholipids in phagocytosis	PE1	10
+NX_Q5W041	Armadillo repeat-containing protein 3	872	96405	5.89	0	NA	NA	NA	NA	NA	NA	PE1	10
+NX_Q5W064	Lipase member J	366	42388	6.11	0	NA	NA	NA	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Formation of the cornified envelope	PE2	10
+NX_Q5W0A0	Glutamate-rich protein 6B	696	81686	4.73	0	NA	NA	NA	NA	Belongs to the ERICH6 family.	NA	PE1	13
+NX_Q5W0B1	ORC ubiquitin ligase 1	726	81116	5.53	0	Cytoplasm;Chromosome;Nucleoplasm;Cytosol;Nucleus	NA	E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578).	Auto-ubiquitinated.	NA	NA	PE1	13
+NX_Q5W0B7	Transmembrane protein 236	351	39663	9.36	6	Membrane	NA	NA	NA	Belongs to the TMEM236 family.	NA	PE1	10
+NX_Q5W0N0	Uncharacterized protein C9orf57	161	18115	8.62	1	Membrane	NA	NA	NA	NA	NA	PE2	9
+NX_Q5W0Q7	SUMO-specific isopeptidase USPL1	1092	120440	5.8	0	Cajal body	NA	SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172).	NA	Belongs to the peptidase C19 family.	NA	PE1	13
+NX_Q5W0U4	B box and SPRY domain-containing protein	402	44381	5.99	0	Membrane;Cytoplasm;Cytosol;Nucleoplasm	NA	May regulate epithelial calcium transport by inhibiting TRPV5 activity.	NA	NA	NA	PE1	9
+NX_Q5W0V3	Protein FAM160B1	765	86558	5.13	0	Cytosol;Nucleus speckle	NA	NA	NA	Belongs to the UPF0518 family.	NA	PE1	10
+NX_Q5W0Z9	Palmitoyltransferase ZDHHC20	365	42278	7.87	4	Cytoplasmic vesicle;Golgi apparatus membrane;Perinuclear region;Cell membrane	NA	Catalyzes palmitoylation of Cys residues on target proteins (PubMed:27153536, PubMed:29326245). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245).	Autopalmitoylated (in vitro).	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	13
+NX_Q5W111	SPRY domain-containing protein 7	196	21666	6.22	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	13
+NX_Q5W150	Putative uncharacterized protein MGC163334	140	15095	9.75	0	NA	NA	NA	NA	NA	NA	PE1	20
+NX_Q5W186	Cystatin-9	159	18135	8.18	0	Secreted	NA	May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation (PubMed:12535658). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria (PubMed:23922243).	NA	Belongs to the cystatin family.	NA	PE2	20
+NX_Q5W188	Putative cystatin-9-like protein CST9LP1	147	17316	4.97	0	Secreted	NA	NA	NA	Belongs to the cystatin family.	NA	PE5	20
+NX_Q5W5W9	Regulated endocrine-specific protein 18	228	24956	5.35	0	Golgi apparatus;Endoplasmic reticulum;Secretory vesicle lumen	NA	May play an important regulatory role in corticotrophs.	NA	Belongs to the RESP18 family.	NA	PE2	2
+NX_Q5W5X9	Tetratricopeptide repeat protein 23	447	50009	8.6	0	Cytosol;Cilium;Cell membrane	NA	Participates positively in the ciliary Hedgehog (Hh) signaling.	NA	NA	NA	PE1	15
+NX_Q5XG85	Putative UPF0633 protein LOC554249	94	10725	11.96	0	NA	NA	NA	NA	Belongs to the UPF0633 family.	NA	PE5	9
+NX_Q5XG87	Terminal nucleotidyltransferase 4A	772	82360	9.56	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Nucleus membrane	NA	Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078).	NA	Belongs to the DNA polymerase type-B-like family.	RNA degradation;Signaling by BRAF and RAF fusions	PE1	5
+NX_Q5XG92	Carboxylesterase 4A	561	63529	9.37	0	Cytosol;Secreted	NA	Probable carboxylesterase.	NA	Belongs to the type-B carboxylesterase/lipase family.	NA	PE1	16
+NX_Q5XG99	LysM and putative peptidoglycan-binding domain-containing protein 4	296	32066	5.99	1	Membrane;Cytosol;Cytoskeleton	NA	NA	NA	NA	NA	PE1	15
+NX_Q5XKE5	Keratin, type II cytoskeletal 79	535	57836	6.75	0	Nucleoplasm;Cytosol;Nucleus membrane	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q5XKK7	Protein FAM219B	198	21103	8.54	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	Belongs to the FAM219 family.	NA	PE1	15
+NX_Q5XKL5	BTB/POZ domain-containing protein 8	378	42793	5.68	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	1
+NX_Q5XKP0	MICOS complex subunit MIC13	118	13087	9.44	1	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	Combined oxidative phosphorylation deficiency 37	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex.	NA	Belongs to the MICOS complex subunit Mic13 family.	Cristae formation	PE1	19
+NX_Q5XKR4	Homeobox protein orthopedia	325	34159	9.54	0	Nucleus	NA	Probably involved in the differentiation of hypothalamic neuroendocrine cells.	NA	Belongs to the paired homeobox family. Bicoid subfamily.	NA	PE1	5
+NX_Q5XKR9	Protein FAM104B	115	13109	9.64	0	NA	NA	NA	NA	Belongs to the FAM104 family.	NA	PE1	X
+NX_Q5XLA6	Caspase recruitment domain-containing protein 17	110	11868	5.34	0	Cytoplasm	NA	Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.	NA	NA	NA	PE1	11
+NX_Q5XPI4	E3 ubiquitin-protein ligase RNF123	1314	148515	6.31	0	Cytoplasm;Cytosol	NA	Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle (PubMed:15531880, PubMed:16227581). Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity (PubMed:27312109). Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS (PubMed:27312109).	Ubiquitinated, leading to its degradation. Deubiquitinated by USP19, thereby stimulating CDKN1B ubiquitin-dependent degradation.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Ub-specific processing proteases	PE1	3
+NX_Q5XUX0	F-box only protein 31	539	60664	6.56	0	Golgi apparatus;Nucleoplasm;Cytosol	Mental retardation, autosomal recessive 45	Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.	Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.	Belongs to the FBXO31 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	16
+NX_Q5XUX1	F-box/WD repeat-containing protein 9	488	54115	6.02	0	Cytosol	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Association of TriC/CCT with target proteins during biosynthesis;Neddylation	PE1	19
+NX_Q5XX13	F-box/WD repeat-containing protein 10	1052	119846	9.47	0	Nucleoplasm	NA	Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Association of TriC/CCT with target proteins during biosynthesis;Neddylation	PE1	17
+NX_Q5XXA6	Anoctamin-1	986	114078	8.76	10	Nucleoplasm;Cytoplasm;Cell membrane	NA	Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.	NA	Belongs to the anoctamin family.	Stimuli-sensing channels	PE1	11
+NX_Q5Y7A7	HLA class II histocompatibility antigen, DRB1-13 beta chain	266	30008	6.51	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;Lysosome membrane;trans-Golgi network membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_Q5YKI7	Putative gametogenetin-binding protein 1	109	12309	5.3	0	Membrane;Cytoplasm;Golgi apparatus	NA	May be involved in spermatogenesis.	NA	NA	NA	PE5	6
+NX_Q5ZPR3	CD276 antigen	534	57235	4.77	1	Membrane;Cytoplasmic vesicle	NA	Is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.;May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses.	NA	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Cell adhesion molecules (CAMs)	PE1	15
+NX_Q60I27	ALS2 C-terminal-like protein	953	107748	5.75	0	Cytoplasm	NA	Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	3
+NX_Q629K1	Triple QxxK/R motif-containing protein	86	9683	9.36	1	Endoplasmic reticulum membrane	NA	May play a role in cell growth and maintenance of cell morphology.	NA	Belongs to the TRIQK family.	NA	PE1	8
+NX_Q63HK3	Zinc finger protein with KRAB and SCAN domains 2	967	110941	8.68	0	Nucleoplasm;Golgi apparatus;Nucleus;Nucleolus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	16
+NX_Q63HK5	Teashirt homolog 3	1081	118566	6.83	0	Mitochondrion;Cell membrane;Growth cone;Nucleoplasm;Nucleus	NA	Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity).	NA	Belongs to the teashirt C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q63HM1	Kynurenine formamidase	303	33992	5.57	0	Cytosol;Mitochondrion;Nucleus	NA	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	NA	Belongs to the kynurenine formamidase family.	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.;Tryptophan metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Tryptophan catabolism	PE1	17
+NX_Q63HM2	Pecanex-like protein 4	1172	132702	5.88	15	Membrane;Cytoplasm;Cytosol;Nucleus	NA	NA	NA	Belongs to the pecanex family.	NA	PE1	14
+NX_Q63HM9	PI-PLC X domain-containing protein 3	321	36313	5.87	0	Golgi apparatus;Cytoplasm	NA	NA	NA	NA	NA	PE1	5
+NX_Q63HN1	Putative protein FAM205B	556	61860	7.14	0	NA	NA	NA	NA	Belongs to the FAM205 family.	NA	PE5	9
+NX_Q63HN8	E3 ubiquitin-protein ligase RNF213	5207	591407	6.05	0	Cytosol	Moyamoya disease 2	E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892, PubMed:26278786, PubMed:26766444, PubMed:26126547). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity (PubMed:24658080, PubMed:26126547).	Autoubiquitinated.	Belongs to the AAA ATPase family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	17
+NX_Q63HQ0	AP-1 complex-associated regulatory protein	302	34280	4.79	0	trans-Golgi network;Golgi apparatus;Cell membrane;Early endosome;Late endosome	NA	Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.	Palmitoylated.	NA	NA	PE1	4
+NX_Q63HQ2	Pikachurin	1017	111271	7.24	0	Presynaptic active zone;Extracellular matrix;Synaptic cleft	NA	Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity).	O-glycosylated; contains chondroitin sulfate and heparan sulfate.	NA	NA	PE1	5
+NX_Q63HR2	Tensin-2	1409	152580	8.67	0	Focal adhesion;Cell membrane	NA	Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.	NA	NA	NA	PE1	12
+NX_Q63ZE4	Solute carrier family 22 member 10	541	60257	8.89	11	Membrane	NA	NA	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	NA	PE2	11
+NX_Q63ZY3	KN motif and ankyrin repeat domain-containing protein 2	851	91174	5.44	0	Cytoplasm;Mitochondrion	Palmoplantar keratoderma and woolly hair;Nephrotic syndrome 16	Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity).	Phosphorylated by casein kinase II upon estrogen stimulation (PubMed:17476305). Phosphorylation induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription (PubMed:17476305).	NA	NA	PE1	19
+NX_Q63ZY6	Putative methyltransferase NSUN5C	315	34347	9.01	0	NA	NA	May have S-adenosyl-L-methionine-dependent methyl-transferase activity.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	NA	PE5	7
+NX_Q641Q2	WASH complex subunit 2A	1341	147184	4.69	0	Early endosome membrane;Cell membrane	NA	Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L.	NA	Belongs to the FAM21 family.	NA	PE1	10
+NX_Q641Q3	Meteorin-like protein	311	34398	8.72	0	Secreted	NA	Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).	NA	Belongs to the meteorin family.	NA	PE1	17
+NX_Q643R3	Lysophospholipid acyltransferase LPCAT4	524	57219	9.17	2	Endoplasmic reticulum membrane	NA	Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors.	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Lipid metabolism; phospholipid metabolism.;Glycerophospholipid metabolism;Ether lipid metabolism;Metabolic pathways;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE	PE1	15
+NX_Q64ET8	Protein FRG2	278	30490	7.6	0	Nucleus	NA	NA	NA	Belongs to the FRG2 family.	NA	PE2	4
+NX_Q64LD2	WD repeat-containing protein 25	544	60161	9.21	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	14
+NX_Q658K8	Putative elongation factor 1-delta-like protein	133	14137	5.94	0	NA	NA	NA	NA	Belongs to the EF-1-beta/EF-1-delta family.	NA	PE5	13
+NX_Q658L1	Stabilizer of axonemal microtubules 2	398	45933	9.12	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	Belongs to the FAM154 family.	NA	PE1	15
+NX_Q658N2	WSC domain-containing protein 1	575	65694	9.34	1	Membrane;Golgi apparatus;Nucleoplasm	NA	NA	NA	Belongs to the WSCD family.	NA	PE1	17
+NX_Q658P3	Metalloreductase STEAP3	488	54601	8.86	6	Cytosol;Nucleolus;Endosome membrane	Anemia, hypochromic microcytic, with iron overload 2	Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.	Glycosylated.;Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.	Belongs to the STEAP family.	p53 signaling pathway;Transferrin endocytosis and recycling;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	PE1	2
+NX_Q658T7	Putative protein FAM90A2P	463	50084	10.2	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE5	8
+NX_Q658Y4	Protein FAM91A1	838	93909	5.95	0	trans-Golgi network;Nucleoplasm;Cytoplasmic vesicle;Cytoskeleton	NA	As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1.	NA	Belongs to the FAM91 family.	NA	PE1	8
+NX_Q659A1	Little elongation complex subunit 2	982	110011	6.69	0	Nucleoplasm;Nucleus	NA	Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.	NA	Belongs to the ICE2 family.	RNA polymerase II transcribes snRNA genes	PE1	15
+NX_Q659C4	La-related protein 1B	914	105322	7.33	0	Cytosol	NA	NA	NA	Belongs to the LARP family.	NA	PE1	4
+NX_Q66GS9	Centrosomal protein of 135 kDa	1140	133490	5.87	0	Focal adhesion;Centriole	Microcephaly 8, primary, autosomal recessive	Involved in early centriole assembly/duplication/biogenesis/formation/. Required for centriole elongation. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.;Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865).	NA	Belongs to the CEP135/TSGA10 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	4
+NX_Q66K14	TBC1 domain family member 9B	1250	140525	5.14	1	Membrane;Nucleoplasm;Nucleolus;Cell membrane	NA	May act as a GTPase-activating protein for Rab family protein(s).	NA	NA	NA	PE1	5
+NX_Q66K41	Zinc finger protein 385C	424	44235	10.42	0	Nucleus	NA	NA	NA	NA	NA	PE1	17
+NX_Q66K64	DDB1- and CUL4-associated factor 15	600	66463	6.14	0	Cytoplasmic vesicle;Mitochondrion	NA	May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase.	NA	NA	Protein modification; protein ubiquitination.	PE1	19
+NX_Q66K66	Transmembrane protein 198	360	39475	9.97	7	Membrane;Cytoplasmic vesicle;Cell membrane	NA	Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.	NA	Belongs to the TMEM198 family.	NA	PE1	2
+NX_Q66K74	Microtubule-associated protein 1S	1059	112211	6.93	0	Cytosol;Spindle;Nucleus;Cytoskeleton	NA	Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).	NA	Belongs to the MAP1 family.	NA	PE1	19
+NX_Q66K79	Carboxypeptidase Z	652	73655	8.22	0	Extracellular matrix;Cell membrane	NA	Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.	NA	Belongs to the peptidase M14 family.	NA	PE1	4
+NX_Q66K80	Putative uncharacterized protein RUSC1-AS1	236	24494	10.2	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q66K89	Transcription factor E4F1	784	83496	5.91	0	Nucleoplasm;Cytoplasm	NA	May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.;Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.	May be sumoylated by UBE2I upon interaction with CDKN2A.;Phosphorylated; p120E4F and p50E4F are both phosphorylated. Phosphorylation is cell cycle-dependent and differentially regulates DNA-binding activity and function of both forms.;Proteolytic cleavage produces a 50 kDa N-terminal peptide (p50E4F) which has a DNA-binding activity and activates transcription in presence of the adenoviral E1A protein. The major full-length protein (p120E4F) functions as a repressor of transcription.	NA	Protein modification; protein ubiquitination.	PE1	16
+NX_Q66LE6	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform	453	52042	5.96	0	Cytoplasm	NA	B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).	NA	Belongs to the phosphatase 2A regulatory subunit B family.	mRNA surveillance pathway;Tight junction;Dopaminergic synapse;Chagas disease (American trypanosomiasis);Hepatitis C;MASTL Facilitates Mitotic Progression	PE1	10
+NX_Q66PJ3	ADP-ribosylation factor-like protein 6-interacting protein 4	421	44915	10.93	0	Nucleus speckle;Nucleolus	NA	Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA.	NA	Belongs to the ARL6IP4 family.	NA	PE1	12
+NX_Q674R7	Autophagy-related protein 9B	924	101019	8.62	6	Autophagosome membrane	NA	Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity).	NA	Belongs to the ATG9 family.	Macroautophagy	PE1	7
+NX_Q674X7	Kazrin	775	86351	6.57	0	Cytoplasm;Nucleus speckle;Desmosome;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.	NA	Belongs to the kazrin family.	Formation of the cornified envelope	PE1	1
+NX_Q676U5	Autophagy-related protein 16-1	607	68265	6.2	0	Cytoplasm;Cytosol;Preautophagosomal structure membrane	Inflammatory bowel disease 10	Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).	Phosphorylation at Ser-139 promotes association with the ATG12-ATG5 conjugate to form the ATG12-ATG5-ATG16L1 complex.;Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli.	Belongs to the WD repeat ATG16 family.	Macroautophagy	PE1	2
+NX_Q67FW5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1	361	40713	6.97	0	Nucleolus	NA	Putative glycosyltransferase.	NA	Belongs to the glycosyltransferase 2 family.	O-linked glycosylation of mucins	PE1	17
+NX_Q684P5	Rap1 GTPase-activating protein 2	730	80056	6.22	0	Cytoplasm;Cytosol;Perinuclear region;Nucleus membrane	NA	GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.	In vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not regulate GAP activity.	NA	Rap1 signalling	PE1	17
+NX_Q685J3	Mucin-17	4493	451741	4.03	1	Secreted;Cell membrane	NA	Probably plays a role in maintaining homeostasis on mucosal surfaces.	N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.;Probably cleaved within the SEA domain.	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	7
+NX_Q687X5	Metalloreductase STEAP4	459	51981	9.39	6	Early endosome membrane;Nucleoplasm;Golgi apparatus membrane;Cell membrane	NA	Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193).	NA	Belongs to the STEAP family.	NA	PE1	7
+NX_Q68BL7	Olfactomedin-like protein 2A	652	73054	7.89	0	Nucleoplasm;Cytosol;Secreted	NA	NA	O-glycosylated but not N-glycosylated.;May be cleaved at Lys-295 after secretion.	NA	NA	PE1	9
+NX_Q68BL8	Olfactomedin-like protein 2B	750	83999	5.07	0	Cytosol;Secreted	NA	NA	O-glycosylated and N-glycosylated.	NA	NA	PE1	1
+NX_Q68CJ6	Nuclear GTPase SLIP-GC	796	91132	8.85	0	Nucleus speckle	NA	Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).	NA	NA	NA	PE1	8
+NX_Q68CJ9	Cyclic AMP-responsive element-binding protein 3-like protein 3	461	49077	4.99	1	Endoplasmic reticulum membrane;Nucleus	NA	Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.	N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1 or possibly core 8 glycans.;Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).	Belongs to the bZIP family. ATF subfamily.	Cholinergic synapse;Dopaminergic synapse;Melanogenesis;Vasopressin-regulated water reabsorption;Huntington's disease;Prostate cancer;CREB3 factors activate genes;Assembly of active LPL and LIPC lipase complexes	PE1	19
+NX_Q68CK6	Acyl-coenzyme A synthetase ACSM2B, mitochondrial	577	64271	8.5	0	Mitochondrion	NA	Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065, PubMed:12616642). Capable of activating medium-chain fatty acids (e.g. Butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. Benzoate (PubMed:10434065, PubMed:12616642).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Butanoate metabolism;Metabolic pathways;Conjugation of salicylate with glycine;Conjugation of benzoate with glycine;Conjugation of phenylacetate with glutamine	PE1	16
+NX_Q68CL5	Tubulin polyglutamylase complex subunit 2	300	33318	6.25	0	Cytoskeleton	NA	NA	NA	NA	Carboxyterminal post-translational modifications of tubulin	PE1	18
+NX_Q68CP4	Heparan-alpha-glucosaminide N-acetyltransferase	663	73293	8.69	11	Lysosome membrane	Mucopolysaccharidosis 3C;Retinitis pigmentosa 73	Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase.	Glycosylated.;Undergoes intralysosomal proteolytic cleavage; occurs within the end of the first and/or the beginning of the second luminal domain and is essential for the activation of the enzyme.	NA	Glycosaminoglycan degradation;Metabolic pathways;Lysosome;HS-GAG degradation;MPS IIIC - Sanfilippo syndrome C;Neutrophil degranulation	PE1	8
+NX_Q68CP9	AT-rich interactive domain-containing protein 2	1835	197391	7.08	0	Nucleoplasm;Nucleus;Cell membrane	Coffin-Siris syndrome 6	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.	NA	NA	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	12
+NX_Q68CQ1	Maestro heat-like repeat-containing protein family member 7	1323	145647	6.51	2	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q68CQ4	Digestive organ expansion factor homolog	756	87055	5.6	0	Nucleolus;Nucleus	NA	Regulates the p53 pathway to control the expansion growth of digestive organs.	NA	Belongs to the def family.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	1
+NX_Q68CQ7	Glycosyltransferase 8 domain-containing protein 1	371	41935	9.37	1	Membrane;Mitochondrion	NA	NA	NA	Belongs to the glycosyltransferase 8 family.	NA	PE1	3
+NX_Q68CR1	Protein sel-1 homolog 3	1132	128567	6.87	1	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	4
+NX_Q68CR7	Leucine-rich repeat-containing protein 66	880	97778	6.01	2	Membrane	NA	NA	NA	NA	NA	PE1	4
+NX_Q68CZ1	Protein fantom	1315	151201	5.21	0	Cytoplasm;Cell membrane;Cilium basal body;Tight junction;Centrosome;Cilium axoneme;Cytosol	COACH syndrome;Meckel syndrome 5;Joubert syndrome 7	Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (PubMed:19464661). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (PubMed:19464661). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (By similarity). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (By similarity).	NA	Belongs to the RPGRIP1 family.	Anchoring of the basal body to the plasma membrane;Hedgehog 'off' state	PE1	16
+NX_Q68CZ2	Tensin-3	1445	155266	6.34	0	Focal adhesion	NA	May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).	EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner.	NA	MET interacts with TNS proteins	PE1	7
+NX_Q68CZ6	HAUS augmin-like complex subunit 3	603	69650	5.4	0	Spindle;Mitochondrion;Centrosome;Cytoskeleton	NA	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.	NA	Belongs to the HAUS3 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	4
+NX_Q68D06	Schlafen family member 13	897	102045	6.55	0	Cytoplasm;Cytoskeleton	NA	Endoribonuclease that cleaves tRNAs and rRNAs (PubMed:29563550). Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem (PubMed:29563550). Does not act on tRNA(Sec) (PubMed:29563550). Able to restrict HIV-1 virus replication; ability to inhibit HIV-1 replication is dependent on endoribonuclease activity (PubMed:29563550).	NA	Belongs to the Schlafen family. Subgroup III subfamily.	NA	PE1	17
+NX_Q68D10	Protein SPT2 homolog	685	75599	9.79	0	Nucleoplasm;Nucleus;Nucleolus	NA	Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026).	SPTY2D1 is phosphorylated by PTK6	Belongs to the SPT2 family.	NA	PE1	11
+NX_Q68D20	Protein PMS2CL	193	20909	5.15	0	NA	NA	NA	NA	Belongs to the DNA mismatch repair MutL/HexB family.	NA	PE1	7
+NX_Q68D42	Transmembrane protein 215	235	25806	5.23	2	Membrane;Endoplasmic reticulum;Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE2	9
+NX_Q68D51	DENN domain-containing protein 2C	928	106865	8.75	0	Nucleoplasm	NA	Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	1
+NX_Q68D85	Natural cytotoxicity triggering receptor 3 ligand 1	454	50827	5.39	1	Cell membrane	NA	Triggers NCR3-dependent natural killer cell activation.	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	11
+NX_Q68D86	Coiled-coil domain-containing protein 102B	513	60448	5.71	0	Cytosol;Mitochondrion	NA	NA	NA	NA	NA	PE1	18
+NX_Q68D91	Metallo-beta-lactamase domain-containing protein 2	279	31372	6.41	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.	NA	PE1	5
+NX_Q68DA7	Formin-1	1419	157578	8.67	0	Cytoplasm;Cell membrane;Adherens junction;Nucleoplasm;Cytosol;Nucleus	NA	Plays a role in the formation of adherens junction and the polymerization of linear actin cables.	Phosphorylated on serine and possibly threonine residues.	Belongs to the formin homology family. Cappuccino subfamily.	NA	PE1	15
+NX_Q68DC2	Ankyrin repeat and SAM domain-containing protein 6	871	92219	6.91	0	Cytoplasm;Cilium;Nucleolus;Nucleoplasm;Cytosol	Nephronophthisis 16	Required for renal function.	Hydroxylated at Asn-138, most probably by HIF1AN. This hydroxylation results in decreased NEK8-binding.	NA	NA	PE1	9
+NX_Q68DD2	Cytosolic phospholipase A2 zeta	849	95082	5.28	0	Nucleoplasm;Cytosol;Lysosome membrane;Cytoplasmic vesicle	NA	Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity).	NA	NA	Fc gamma R-mediated phagocytosis;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC	PE1	15
+NX_Q68DE3	Basic helix-loop-helix domain-containing protein USF3	2245	241653	7.41	0	Nucleoplasm;Nucleolus;Centrosome;Nucleus	NA	Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties.	NA	NA	NA	PE1	3
+NX_Q68DH5	G-protein coupled receptor-associated protein LMBRD2	695	81172	7.25	9	Nucleoplasm;Cytosol;Cell membrane	NA	Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway (PubMed:28388415). May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable).	NA	Belongs to the LIMR family.	NA	PE1	5
+NX_Q68DI1	Zinc finger protein 776	518	59613	8.68	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q68DK2	Zinc finger FYVE domain-containing protein 26	2539	284576	5.97	0	Centrosome;Midbody	Spastic paraplegia 15, autosomal recessive	Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.	NA	NA	NA	PE1	14
+NX_Q68DK7	Male-specific lethal 1 homolog	614	67128	9.1	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026).	Sumoylated with SUMO1.	Belongs to the msl-1 family.	HATs acetylate histones	PE1	17
+NX_Q68DL7	Uncharacterized protein C18orf63	685	77230	9.83	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	18
+NX_Q68DN1	Uncharacterized protein C2orf16	1984	224321	10.09	0	Nucleus	NA	NA	NA	NA	NA	PE1	2
+NX_Q68DQ2	Very large A-kinase anchor protein	2970	330633	5.1	0	Nucleoplasm;Cytosol	NA	Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	3
+NX_Q68DU8	BTB/POZ domain-containing protein KCTD16	428	49138	8.4	0	Nucleus speckle;Presynaptic cell membrane;Postsynaptic cell membrane	NA	Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).	NA	NA	NA	PE1	5
+NX_Q68DV7	E3 ubiquitin-protein ligase RNF43	783	85722	8.1	1	Endoplasmic reticulum membrane;Nucleus envelope;Cell membrane	Sessile serrated polyposis cancer syndrome	E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity).	Autoubiquitinated.	Belongs to the ZNRF3 family.	Protein modification; protein ubiquitination.;Regulation of FZD by ubiquitination;RNF mutants show enhanced WNT signaling and proliferation	PE1	17
+NX_Q68DX3	FERM and PDZ domain-containing protein 2	1309	144282	6.29	0	Cytoplasm;Tight junction;Basolateral cell membrane	NA	May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2).	NA	NA	NA	PE1	10
+NX_Q68DY1	Zinc finger protein 626	528	60893	9.29	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus membrane;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q68DY9	Zinc finger protein 772	489	55367	7.78	0	Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q68E01	Integrator complex subunit 3	1043	118070	5.53	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.;Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).	NA	Belongs to the Integrator subunit 3 family.	RNA polymerase II transcribes snRNA genes	PE1	1
+NX_Q68EA5	Zinc finger protein 57	555	64428	9.06	0	Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q68EM7	Rho GTPase-activating protein 17	881	95437	7.22	0	Cytoplasm;Cell membrane;Membrane;Nucleoplasm;Tight junction;Cytosol	NA	Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.	NA	NA	Rho GTPase cycle	PE1	16
+NX_Q68EN5	Uncharacterized protein KIAA0895-like	471	53446	9.27	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	16
+NX_Q68G74	LIM/homeobox protein Lhx8	356	39301	8.61	0	Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor involved in differentiation of certain neurons and mesenchymal cells.	NA	NA	NA	PE1	1
+NX_Q68G75	LEM domain-containing protein 1	181	20326	8.74	1	Membrane;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	1
+NX_Q68J44	Dual specificity phosphatase DUPD1	220	25336	5.68	0	Cytoplasm	NA	Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	10
+NX_Q69383	Endogenous retrovirus group K member 6 Rec protein	105	11828	10.22	0	Cytoplasm;Nucleolus	NA	Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts.	NA	NA	NA	PE1	7
+NX_Q69384	Endogenous retrovirus group K member 6 Env polyprotein	699	79218	9.14	1	Virion;Cell membrane	NA	Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.;SU mediates receptor recognition.;TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.	NA	PE1	7
+NX_Q693B1	BTB/POZ domain-containing protein KCTD11	232	25887	6.2	0	Nucleoplasm	NA	Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.	NA	NA	Protein modification; protein ubiquitination.	PE1	17
+NX_Q695T7	Sodium-dependent neutral amino acid transporter B(0)AT1	634	71110	4.92	12	Apical cell membrane;Cell membrane	Hartnup disorder;Iminoglycinuria;Hyperglycinuria	Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:18424768, PubMed:18484095, PubMed:19185582, PubMed:26240152). This uptake is sodium-dependent and chloride-independent (PubMed:19185582, PubMed:15286788). Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:19185582, PubMed:18424768).	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily.	Protein digestion and absorption;Mineral absorption;Amino acid transport across the plasma membrane;Na+/Cl- dependent neurotransmitter transporters;Defective SLC6A19 causes Hartnup disorder (HND);Defective SLC6A19 causes Hartnup disorder (HND)	PE1	5
+NX_Q69YG0	Transmembrane protein 42	159	16991	8.97	4	Membrane;Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	3
+NX_Q69YH5	Cell division cycle-associated protein 2	1023	112676	8.71	0	Nucleoplasm;Nucleus	NA	Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.	Phosphorylated by CDK1. May regulate its subcellular location.	NA	NA	PE1	8
+NX_Q69YI7	Nuclear apoptosis-inducing factor 1	327	35164	6.73	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Induces apoptosis.	NA	Belongs to the NAIF1 family.	NA	PE1	9
+NX_Q69YL0	Protein NCBP2AS2	99	10891	12	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_Q69YN2	CWF19-like protein 1	538	60619	6.87	0	Golgi apparatus;Nucleoplasm	Spinocerebellar ataxia, autosomal recessive, 17	NA	NA	Belongs to the CWF19 family.	NA	PE1	10
+NX_Q69YN4	Protein virilizer homolog	1812	202025	4.9	0	Nucleoplasm;Cytoplasm;Nucleus speckle;Nucleus	NA	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755).	NA	Belongs to the vir family.	NA	PE1	8
+NX_Q69YQ0	Cytospin-A	1117	124602	5.52	0	Spindle;Gap junction;Cytoskeleton	Facial clefting, oblique, 1;Opitz GBBB syndrome 2;Hypertelorism, Teebi type	Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.	NA	Belongs to the cytospin-A family.	NA	PE1	22
+NX_Q69YU3	Ankyrin repeat domain-containing protein 34A	496	52636	9.5	0	Cytosol	NA	NA	Methylated at Gln-15 by N6AMT1.	Belongs to the ANKRD34 family.	NA	PE1	1
+NX_Q69YU5	Uncharacterized protein C12orf73	71	8023	9.21	0	Centrosome;Mitochondrion;Secreted;Cell membrane	NA	NA	NA	NA	NA	PE1	12
+NX_Q69YW2	Protein stum homolog	141	15007	6.7	2	Membrane;Cytosol;Cell membrane	NA	NA	NA	Belongs to the SPEC3 family. Stum subfamily.	NA	PE1	1
+NX_Q69YZ2	Transmembrane protein 200B	307	32750	11.44	2	Membrane	NA	NA	NA	Belongs to the TMEM200 family.	NA	PE1	1
+NX_Q6A162	Keratin, type I cytoskeletal 40	431	48139	4.35	0	NA	NA	May play a role in late hair differentiation.	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q6A163	Keratin, type I cytoskeletal 39	491	55651	5.19	0	NA	NA	May play a role in late hair differentiation.	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q6A1A2	Putative 3-phosphoinositide-dependent protein kinase 2	396	44765	8.61	0	Membrane;Cytoplasm	NA	Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity).	Phosphorylated on tyrosine and serine/threonine.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.	NA	PE5	16
+NX_Q6A555	Thioredoxin domain-containing protein 8	127	14575	9.56	0	Golgi apparatus;Cytoplasm	NA	May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.	NA	Belongs to the thioredoxin family.	NA	PE1	9
+NX_Q6AHZ1	Zinc finger protein 518A	1483	166782	9.38	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	10
+NX_Q6AI08	HEAT repeat-containing protein 6	1181	128781	6.64	0	Mitochondrion	NA	Amplification-dependent oncogene.	NA	NA	NA	PE1	17
+NX_Q6AI12	Ankyrin repeat domain-containing protein 40	368	41088	4.88	0	Golgi apparatus;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	17
+NX_Q6AI14	Sodium/hydrogen exchanger 4	798	89814	8.76	10	Cell membrane;Basolateral cell membrane;Nucleoplasm;Cytoplasmic granule membrane;Apical cell membrane	NA	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity).	May be phosphorylated.	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Gastric acid secretion;Sodium/Proton exchangers	PE2	2
+NX_Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	1079	115084	6.38	0	Nucleoplasm	NA	Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.	NA	NA	NA	PE1	6
+NX_Q6AW86	Zinc finger protein 324B	544	60602	9.78	0	Nucleolus;Nucleus;Cytosol	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6AWC2	Protein WWC2	1192	133891	5.4	0	Cytoskeleton	NA	NA	NA	Belongs to the WWC family.	NA	PE1	4
+NX_Q6AWC8	Putative uncharacterized protein LOC100129027	147	16804	9.84	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q6AZW8	Zinc finger protein 660	331	38270	9.46	0	Nucleolus;Nucleus;Cytosol	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	3
+NX_Q6AZY7	Scavenger receptor class A member 3	606	65137	6.08	1	Golgi apparatus;Endoplasmic reticulum membrane;Endoplasmic reticulum;Golgi apparatus membrane;Cytosol	NA	Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.	NA	NA	NA	PE1	8
+NX_Q6AZZ1	E3 ubiquitin-protein ligase TRIM68	485	56259	6.07	0	Nucleoplasm;Cytosol;Perinuclear region;Nucleus	NA	Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.	Auto-ubiquitinated.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Interferon gamma signaling	PE1	11
+NX_Q6B0B8	Tigger transposable element-derived protein 3	471	52027	7.12	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	NA	NA	Belongs to the tigger transposable element derived protein family.	NA	PE1	11
+NX_Q6B0I6	Lysine-specific demethylase 4D	523	58603	9.28	0	Nucleoplasm;Nucleus	NA	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.	NA	Belongs to the JHDM3 histone demethylase family.	HDMs demethylate histones	PE1	11
+NX_Q6B0K9	Hemoglobin subunit mu	141	15618	6.12	0	NA	NA	NA	NA	Belongs to the globin family.	NA	PE1	16
+NX_Q6B8I1	Dual specificity protein phosphatase 13 isoform A	188	20658	7.08	0	Cytoplasm	NA	Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates (PubMed:15252030, PubMed:29106959). Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	10
+NX_Q6B9Z1	Insulin growth factor-like family member 4	124	13885	6.06	0	Cytosol;Secreted	NA	NA	NA	Belongs to the IGFL family.	NA	PE2	19
+NX_Q6BAA4	Fc receptor-like B	426	46904	9.16	0	Endoplasmic reticulum;Cytosol;Cytoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_Q6BCY4	NADH-cytochrome b5 reductase 2	276	31458	8.49	0	Golgi apparatus;Nucleoplasm	NA	NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1).	NA	Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Amino sugar and nucleotide sugar metabolism;Erythrocytes take up carbon dioxide and release oxygen	PE1	11
+NX_Q6BDI9	Rab15 effector protein	236	26571	6.89	0	Early endosome membrane	NA	Regulates transferrin receptor recycling from the endocytic recycling compartment.	NA	NA	NA	PE1	12
+NX_Q6BDS2	UHRF1-binding protein 1	1440	159485	5.75	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus membrane	NA	May act as a negative regulator of cell growth.	NA	NA	NA	PE1	6
+NX_Q6BEB4	Transcription factor Sp5	398	41964	9.43	0	Nucleoplasm;Nucleolus;Nucleus	NA	Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	2
+NX_Q6DCA0	AMMECR1-like protein	310	34499	9.18	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	2
+NX_Q6DD87	Zinc finger protein 787	382	40428	8.25	0	Nucleoplasm;Nucleus;Mitochondrion;Nucleolus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q6DD88	Atlastin-3	541	60542	5.43	2	Endoplasmic reticulum;Endoplasmic reticulum membrane	Neuropathy, hereditary sensory, 1F	GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977).	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	NA	PE1	11
+NX_Q6DHV5	Protein CC2D2B	1058	122955	6.68	0	Nucleolus	NA	NA	NA	NA	NA	PE2	10
+NX_Q6DHV7	Adenosine deaminase-like protein	355	40264	5.89	0	Cytoskeleton	NA	Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).	NA	Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	Abacavir metabolism;Purine salvage	PE1	15
+NX_Q6DHY5	TBC1 domain family member 3G	549	62231	9.2	0	Cell membrane	NA	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).	Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.;Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.	NA	NA	PE1	17
+NX_Q6DJT9	Zinc finger protein PLAG1	500	55909	8.84	0	Nucleus speckle;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.	Sumoylated with SUMO1; which inhibits transcriptional activity, but does not affect nuclear localization. Blockers of sumoylation pathway such as SENP3 and inactive UBE2I increases transcriptional capacity. Sumoylation is increased in the presence of PIAS1.;Acetylated by lysine acetyltransferase EP300; which activates transcriptional capacity. Lysine residues that are sumoylated also seem to be target for acetylation.	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_Q6DKI1	60S ribosomal protein L7-like 1	255	29669	10.52	0	Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the universal ribosomal protein uL30 family.	NA	PE1	6
+NX_Q6DKI2	Galectin-9C	356	39607	9.36	0	NA	NA	Binds galactosides.	NA	NA	NA	PE1	17
+NX_Q6DKI7	Transmembrane protein PVRIG	326	34344	9.27	3	Endoplasmic reticulum;Nucleolus;Cell membrane	NA	Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.	NA	NA	NA	PE1	7
+NX_Q6DKJ4	Nucleoredoxin	435	48392	4.88	0	Golgi apparatus;Cytosol;Nucleus	NA	Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).	NA	Belongs to the nucleoredoxin family.	NA	PE1	17
+NX_Q6DKK2	Tetratricopeptide repeat protein 19, mitochondrial	380	42457	5.57	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex III deficiency, nuclear 2	Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1 (PubMed:21278747, PubMed:28673544). Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity (PubMed:28673544).	NA	Belongs to the TTC19 family.	NA	PE1	17
+NX_Q6DN03	Putative histone H2B type 2-C	193	21472	10.7	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.	Belongs to the histone H2B family.	NA	PE5	1
+NX_Q6DN12	Multiple C2 and transmembrane domain-containing protein 2	878	99596	7.48	2	Membrane;Nucleoplasm;Cytosol	NA	Might play a role in the development of cardiac outflow tract.	NA	Belongs to the MCTP family.	NA	PE1	15
+NX_Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	999	111624	8.39	2	Endoplasmic reticulum membrane;Recycling endosome;Nucleoplasm;Synaptic vesicle membrane;Cytosol	NA	Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity.	NA	Belongs to the MCTP family.	NA	PE1	5
+NX_Q6DN72	Fc receptor-like protein 6	434	47748	7.53	1	Cell membrane	NA	Acts as a MHC class II receptor (PubMed:20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291). Does not act as an Fc receptor (PubMed:18991291).	Phosphorylated on Tyr residues. Tyrosine phosphorylation induces association with phosphatase PTPN11, PTPN6, INPP5D, INPPL1 and GRB2.	NA	NA	PE1	1
+NX_Q6DN90	IQ motif and SEC7 domain-containing protein 1	963	108314	6.49	0	Cytoplasm;Nucleolus;Nucleus;Cytoplasmic vesicle	NA	Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.	NA	Belongs to the BRAG family.	Endocytosis	PE1	3
+NX_Q6DRA6	Putative histone H2B type 2-D	164	18018	10.6	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.	Belongs to the histone H2B family.	NA	PE5	1
+NX_Q6DT37	Serine/threonine-protein kinase MRCK gamma	1551	172459	5.91	0	Cytoplasm;Cytosol	NA	May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.	NA	PE1	11
+NX_Q6DWJ6	Probable G-protein coupled receptor 139	353	40679	9.43	7	Cell membrane	NA	Orphan receptor. Seems to act through a G(q/11)-mediated pathway.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	16
+NX_Q6E0U4	Dermokine	476	47082	6.8	0	Nucleoplasm;Cytosol;Secreted	NA	May act as a soluble regulator of keratinocyte differentiation.	O-glycosylated.	Belongs to the dermokine family.	NA	PE1	19
+NX_Q6E213	Acyl-CoA wax alcohol acyltransferase 2	333	38094	9.42	3	Endoplasmic reticulum membrane	NA	Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349, PubMed:15671038, PubMed:16106050, PubMed:28420705). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively (PubMed:15220349, PubMed:15671038). Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis-specific retinyl ester synthesis (PubMed:16106050, PubMed:24799687). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates (PubMed:24799687).	NA	Belongs to the diacylglycerol acyltransferase family.	Retinol metabolism;Vitamin digestion and absorption;Acyl chain remodeling of DAG and TAG;The retinoid cycle in cones (daylight vision);Wax biosynthesis	PE1	X
+NX_Q6EBC2	Interleukin-31	164	18205	5.28	0	Secreted	NA	Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).	NA	NA	IL-6-type cytokine receptor ligand interactions	PE1	12
+NX_Q6ECI4	Zinc finger protein 470	717	82650	8.91	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6EEV4	DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5	148	15131	8.68	0	NA	NA	NA	NA	NA	NA	PE1	15
+NX_Q6EEV6	Small ubiquitin-related modifier 4	95	10685	6.57	0	NA	Diabetes mellitus, insulin-dependent, 5	Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.	In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.	Belongs to the ubiquitin family. SUMO subfamily.	RNA transport	PE1	6
+NX_Q6EIG7	C-type lectin domain family 6 member A	209	23998	5.86	1	Membrane	NA	Binds high-mannose carbohydrates in a Ca(2+)-dependent manner (PubMed:28652405). Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity).	NA	NA	Dectin-2 family	PE1	12
+NX_Q6EKJ0	General transcription factor II-I repeat domain-containing protein 2B	949	107233	5.62	0	Nucleus	NA	NA	NA	Belongs to the TFII-I family.	NA	PE1	7
+NX_Q6EMB2	Tubulin polyglutamylase TTLL5	1281	143577	8.82	0	Cytoplasm;Cell membrane;Cilium;Cilium basal body;Nucleus envelope;Cytosol;Nucleus	Cone-rod dystrophy 19	Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691).	NA	Belongs to the tubulin--tyrosine ligase family.	Carboxyterminal post-translational modifications of tubulin	PE1	14
+NX_Q6EMK4	Vasorin	673	71713	7.16	1	Mitochondrion;Secreted;Nucleolus;Membrane;Nucleoplasm	NA	May act as an inhibitor of TGF-beta signaling.	N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor).	NA	NA	PE1	16
+NX_Q6F5E7	Protein TXNRD3NB	133	14331	8.23	0	NA	NA	NA	NA	NA	NA	PE2	3
+NX_Q6F5E8	Capping protein, Arp2/3 and myosin-I linker protein 2	1435	154689	6.31	0	Cytoplasm;Cell membrane;Lamellipodium;Ruffle;Cytoskeleton	Immunodeficiency 58	Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647349, PubMed:27647348, PubMed:28112205).	NA	Belongs to the CARMIL family.	NA	PE1	16
+NX_Q6FHJ7	Secreted frizzled-related protein 4	346	39827	9.12	0	Secreted	Pyle disease	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).	NA	Belongs to the secreted frizzled-related protein (sFRP) family.	Wnt signaling pathway	PE1	7
+NX_Q6FI13	Histone H2A type 2-A	130	14095	10.9	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Deiminated on Arg-4 in granulocytes upon calcium entry.;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.;Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).	Belongs to the histone H2A family.	Systemic lupus erythematosus;Systemic lupus erythematosus;Transcriptional regulation by small RNAs;RMTs methylate histone arginines;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	1
+NX_Q6FI81	Anamorsin	312	33582	5.44	0	Cytoplasm;Mitochondrion intermembrane space;Mitochondrion;Nucleus	NA	Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity).	NA	Belongs to the anamorsin family.	Cytosolic iron-sulfur cluster assembly	PE1	16
+NX_Q6FIF0	AN1-type zinc finger protein 6	208	22555	6.87	0	Cytoplasm	NA	Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).	NA	NA	Peroxisomal protein import	PE1	15
+NX_Q6GMR7	Fatty-acid amide hydrolase 2	532	58304	9.2	1	Membrane	NA	Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.	NA	Belongs to the amidase family.	Arachidonic acid metabolism	PE1	X
+NX_Q6GMV1	Putative glycosyltransferase ALG1-like	187	21132	4.96	0	NA	NA	Putative glycosyltransferase.	NA	Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.	NA	PE2	3
+NX_Q6GMV2	SET and MYND domain-containing protein 5	418	47341	4.98	0	Mitochondrion	NA	NA	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE1	2
+NX_Q6GMV3	Putative peptidyl-tRNA hydrolase PTRHD1	140	15805	9.2	0	Nucleoplasm	NA	NA	NA	Belongs to the PTH2 family. PTRHD1 subfamily.	NA	PE1	2
+NX_Q6GPH4	XIAP-associated factor 1	301	34626	8.57	0	Nucleoplasm;Cytoplasm;Mitochondrion;Nucleus	NA	Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.	NA	NA	Interferon alpha/beta signaling	PE1	17
+NX_Q6GPH6	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1	555	63395	6	1	Membrane	NA	NA	NA	Belongs to the ITPRIP family.	NA	PE1	2
+NX_Q6GPI1	Chymotrypsinogen B2	263	27923	7.98	0	Extracellular space	NA	NA	NA	Belongs to the peptidase S1 family.	Cobalamin (Cbl, vitamin B12) transport and metabolism;Activation of Matrix Metalloproteinases	PE1	16
+NX_Q6GQQ9	OTU domain-containing protein 7B	843	92526	6.27	0	Nucleoplasm;Cytoplasm;Nucleus;Cytoskeleton	NA	Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.	Phosphorylated by EGFR.	Belongs to the peptidase C64 family.	TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ovarian tumor domain proteases	PE1	1
+NX_Q6GTS8	N-fatty-acyl-amino acid synthase/hydrolase PM20D1	502	55741	6.2	0	Secreted	NA	Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration.	NA	Belongs to the peptidase M20A family.	NA	PE1	1
+NX_Q6GTX8	Leukocyte-associated immunoglobulin-like receptor 1	287	31412	5.4	1	Cell membrane	NA	Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.	N-glycosylated.;Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK.	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Neutrophil degranulation	PE1	19
+NX_Q6GV28	Transmembrane protein 225	225	25828	8.4	4	Acrosome membrane	NA	Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.	NA	NA	NA	PE2	11
+NX_Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	2036	229832	5.79	0	Cytoplasm;Cytosol;Mitochondrion;Nucleus	NA	Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.	NA	NA	NA	PE1	14
+NX_Q6H3X3	UL-16 binding protein 5	334	37106	6.88	1	Cell membrane;Endoplasmic reticulum;Secreted;Cytoplasmic vesicle	NA	Stimulates natural killer cells to secrete IFNG.;Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.;Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG.	The functional form is cleaved C-terminally of the GPI-anchor and yields a 28 kDa protein.	Belongs to the MHC class I family.	Natural killer cell mediated cytotoxicity;Post-translational modification: synthesis of GPI-anchored proteins	PE1	6
+NX_Q6H8Q1	Actin-binding LIM protein 2	611	67812	8.29	0	Cytoplasm;Nucleoplasm;Mitochondrion	NA	May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.	NA	NA	Axon guidance;DCC mediated attractive signaling	PE1	4
+NX_Q6H9L7	Isthmin-2	571	63906	4.7	0	Nucleoplasm;Secreted	NA	NA	NA	Belongs to the isthmin family.	NA	PE1	14
+NX_Q6HA08	Astacin-like metalloendopeptidase	431	45936	7.67	0	Cytoplasm;Cytoplasmic granule;Secretory vesicle;Cell membrane	NA	Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity).	NA	NA	NA	PE1	2
+NX_Q6I9Y2	THO complex subunit 7 homolog	204	23743	5.47	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	NA	The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.;Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.	NA	Belongs to the THOC7 family.	RNA transport;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	3
+NX_Q6IA17	Single Ig IL-1-related receptor	410	45679	6.02	1	Membrane;Cytosol;Nucleolus	NA	Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.	NA	Belongs to the interleukin-1 receptor family.	MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Interleukin-37 signaling	PE1	11
+NX_Q6IA69	Glutamine-dependent NAD(+) synthetase	706	79285	6.02	0	Golgi apparatus;Cytosol;Cytoplasmic vesicle	NA	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD (PubMed:12547821). Uses L-glutamine as a nitrogen source (PubMed:12547821).	NA	In the C-terminal section; belongs to the NAD synthetase family.	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.;Nicotinate and nicotinamide metabolism;Metabolic pathways;Nicotinate metabolism	PE1	11
+NX_Q6IA86	Elongator complex protein 2	826	92500	5.6	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Mental retardation, autosomal recessive 58	Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244).	NA	Belongs to the WD repeat ELP2 family.	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.;HATs acetylate histones	PE1	18
+NX_Q6IAA8	Ragulator complex protein LAMTOR1	161	17745	5.01	0	Golgi apparatus;Cell membrane;Lysosome membrane;Cytoplasmic vesicle;Late endosome membrane	NA	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.	NA	Belongs to the LAMTOR1 family.	Macroautophagy;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;mTOR signalling;mTORC1-mediated signalling;Neutrophil degranulation;Regulation of PTEN gene transcription	PE1	11
+NX_Q6IAN0	Dehydrogenase/reductase SDR family member 7B	325	35119	9.59	1	Cytosol;Cell junction;Endoplasmic reticulum membrane;Cell membrane	NA	Putative oxidoreductase.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Plasmalogen biosynthesis	PE1	17
+NX_Q6IB77	Glycine N-acyltransferase	296	33924	8.38	0	Mitochondrion	NA	Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.	NA	Belongs to the glycine N-acyltransferase family.	Conjugation of salicylate with glycine;Conjugation of benzoate with glycine	PE1	11
+NX_Q6IBS0	Twinfilin-2	349	39548	6.37	0	Stereocilium;Perinuclear region;Cell membrane;Cytoskeleton	NA	Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).	In vitro, phosphorylated by PRKCZ, CK2 and SRC.	Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.	NA	PE1	3
+NX_Q6IBW4	Condensin-2 complex subunit H2	605	68227	4.66	0	Nucleoplasm;Nucleus;Chromosome;Cytoskeleton	NA	Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007).	NA	Belongs to the CND2 H2 (condensin-2 subunit 2) family.	Condensation of Prophase Chromosomes	PE1	22
+NX_Q6IC83	Uncharacterized protein C22orf42	251	27691	5.02	0	NA	NA	NA	NA	NA	NA	PE2	22
+NX_Q6IC98	GRAM domain-containing protein 4	578	66408	8.98	3	Mitochondrion membrane;Endoplasmic reticulum membrane	NA	Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity).	NA	NA	NA	PE1	22
+NX_Q6ICB0	Desumoylating isopeptidase 1	168	18263	4.86	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234).	NA	Belongs to the DeSI family.	NA	PE1	22
+NX_Q6ICB4	Sesquipedalian-2	259	28338	6.66	0	trans-Golgi network;Clathrin-coated vesicle;Early endosome;Recycling endosome	NA	Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.	NA	Belongs to the sesquipedalian family.	NA	PE1	22
+NX_Q6ICC9	Retrotransposon Gag-like protein 6	239	26154	11.18	0	Cytosol;Nucleus speckle	NA	NA	NA	Belongs to the LDOC1 family.	NA	PE1	22
+NX_Q6ICG6	Uncharacterized protein KIAA0930	404	45794	8.06	0	Mitochondrion;Nucleus membrane	NA	NA	NA	NA	NA	PE1	22
+NX_Q6ICG8	Postacrosomal sheath WW domain-binding protein	309	31909	7.66	0	NA	NA	May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.	NA	NA	NA	PE1	22
+NX_Q6ICH7	Aspartate beta-hydroxylase domain-containing protein 2	369	41699	7.47	1	Membrane	NA	May function as 2-oxoglutarate-dependent dioxygenase.	NA	Belongs to the aspartyl/asparaginyl beta-hydroxylase family.	NA	PE1	22
+NX_Q6ICI0	Transmembrane protein 211	200	21740	8.82	4	Membrane	NA	NA	NA	Belongs to the TMEM211 family.	NA	PE2	22
+NX_Q6ICL3	Transport and Golgi organization protein 2 homolog	276	30937	5.04	0	Golgi apparatus	Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration	NA	NA	Belongs to the Tango2 family.	NA	PE1	22
+NX_Q6ICL7	Solute carrier family 35 member E4	350	36747	9.66	8	Membrane;Cytosol	NA	Putative transporter.	NA	Belongs to the TPT transporter family. SLC35E subfamily.	NA	PE1	22
+NX_Q6IE36	Ovostatin homolog 2	1432	161251	5.16	0	Secreted	NA	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.	NA	Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.	NA	PE2	12
+NX_Q6IE37	Ovostatin homolog 1	1185	134499	5.17	0	Secreted	NA	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.	NA	Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.	NA	PE2	12
+NX_Q6IE38	Serine protease inhibitor Kazal-type 14	97	11057	9.17	0	Secreted	NA	May be a serine protease inhibitor.	NA	NA	NA	PE2	5
+NX_Q6IE81	Protein Jade-1	842	95533	8.2	0	Cytoplasm;Nucleus;Mitochondrion;Cilium basal body	NA	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.	NA	Belongs to the JADE family.	HATs acetylate histones	PE1	4
+NX_Q6IED9	Putative diacylglycerol O-acyltransferase 2-like protein DGAT2L7P	249	27571	9.67	0	NA	NA	Probable acyltransferase uses fatty acyl-CoA as substrate.	NA	Belongs to the diacylglycerol acyltransferase family.	Acyl chain remodeling of DAG and TAG	PE5	7
+NX_Q6IEE7	Transmembrane protein 132E	1074	116150	5.66	1	Golgi apparatus;Membrane;Nucleoplasm;Cytosol;Nucleus	Deafness, autosomal recessive, 99	Required for normal inner ear hair cell function and hearing.	NA	Belongs to the TMEM132 family.	NA	PE1	17
+NX_Q6IEE8	Schlafen family member 12-like	588	67096	8.34	1	Membrane	NA	NA	NA	Belongs to the Schlafen family.	NA	PE2	17
+NX_Q6IEG0	U11/U12 small nuclear ribonucleoprotein 48 kDa protein	339	39965	6.49	0	Nucleoplasm;Cytosol;Nucleus	NA	Likely involved in U12-type 5' splice site recognition.	NA	NA	mRNA Splicing - Minor Pathway	PE1	6
+NX_Q6IEU7	Olfactory receptor 5M10	315	35592	8.56	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q6IEV9	Olfactory receptor 4C11	310	35003	9.11	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q6IEY1	Olfactory receptor 4F3/4F16/4F29	312	35074	9.04	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory transduction;Olfactory Signaling Pathway	PE2	5
+NX_Q6IEZ7	Olfactory receptor 2T5	315	35595	8.71	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q6IF00	Olfactory receptor 2T2	324	36228	9.03	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q6IF36	Putative olfactory receptor 8G2	304	33950	7.11	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	11
+NX_Q6IF42	Olfactory receptor 2A2	318	35820	8.74	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_Q6IF63	Olfactory receptor 52W1	320	34414	9.04	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q6IF82	Olfactory receptor 4A47	309	34760	8.77	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q6IF99	Olfactory receptor 10K2	312	35029	8.92	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q6IFG1	Olfactory receptor 52E8	317	35913	9.4	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q6IFH4	Olfactory receptor 6B2	312	35029	8.41	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	2
+NX_Q6IFN5	Olfactory receptor 7E24	339	38279	7.14	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_Q6IMI4	Sulfotransferase 6B1	303	34919	6.01	0	Cytoplasm	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).	NA	Belongs to the sulfotransferase 1 family.	Cytosolic sulfonation of small molecules	PE2	2
+NX_Q6IMI6	Sulfotransferase 1C3	304	35889	6.43	0	Cytoplasm	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.	NA	Belongs to the sulfotransferase 1 family.	NA	PE1	2
+NX_Q6IMN6	Caprin-2	1127	125925	6.28	0	Cytoplasm;Mitochondrion;Cell membrane;Nucleoplasm;Centrosome;Cytosol	NA	Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112).	NA	Belongs to the caprin family.	NA	PE1	12
+NX_Q6IN84	rRNA methyltransferase 1, mitochondrial	353	38638	8.15	0	Mitochondrion	NA	S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.	NA	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.	rRNA modification in the mitochondrion	PE1	17
+NX_Q6IN85	Serine/threonine-protein phosphatase 4 regulatory subunit 3A	833	95368	4.83	0	Cytoplasm;Nucleus speckle;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.	NA	Belongs to the SMEK family.	NA	PE1	14
+NX_Q6IN97	Putative protein FRMPD2-like	320	35161	5.87	0	NA	NA	NA	NA	NA	NA	PE5	10
+NX_Q6IPM2	IQ domain-containing protein E	695	77298	9.15	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cilium membrane;Cytosol	Polydactyly, postaxial, A7	Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682).	NA	NA	Activation of SMO	PE1	7
+NX_Q6IPR1	Electron transfer flavoprotein regulatory factor 1	90	10864	9.92	0	Mitochondrion	NA	Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB).	NA	Belongs to the complex I LYR family.	NA	PE1	12
+NX_Q6IPR3	tRNA wybutosine-synthesizing protein 3 homolog	259	29794	7.59	0	Cytosol;Cell membrane	NA	Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).	NA	Belongs to the TYW3 family.	tRNA modification; wybutosine-tRNA(Phe) biosynthesis.;Synthesis of wybutosine at G37 of tRNA(Phe)	PE1	1
+NX_Q6IPT2	Protein FAM71E1	247	27609	8.86	0	Nucleolus	NA	NA	NA	Belongs to the FAM71 family.	NA	PE1	19
+NX_Q6IPT4	NADH-cytochrome b5 reductase-like	315	35892	5.05	0	Nucleoplasm	NA	NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	NA	Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Erythrocytes take up carbon dioxide and release oxygen	PE2	1
+NX_Q6IPU0	Centromere protein P	288	33165	5.9	0	Nucleus;Nucleoplasm;Centromere;Nucleolus	NA	Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.	NA	Belongs to the CENP-P/CTF19 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	9
+NX_Q6IPW1	Uncharacterized protein C11orf71	123	13249	11.73	0	Nucleoplasm	NA	NA	NA	NA	NA	PE2	11
+NX_Q6IPX1	TBC1 domain family member 3C	549	62187	9.24	0	Cell membrane	NA	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).	Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.;Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.	NA	NA	PE2	17
+NX_Q6IPX3	Transcription elongation factor A protein-like 6	200	22298	5.15	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the TFS-II family. TFA subfamily.	NA	PE1	X
+NX_Q6IQ16	Speckle-type POZ protein-like	392	44647	6.99	0	Cytoplasmic vesicle;Nucleus	NA	Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.	NA	Belongs to the Tdpoz family.	Protein modification; protein ubiquitination.;Hedgehog 'on' state	PE1	2
+NX_Q6IQ19	Centriole, cilia and spindle-associated protein	270	30216	7.7	0	Centriole;Cilium;Cilium basal body;Spindle;Centrosome;Cilium axoneme;Axon;Cytoskeleton	NA	Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity).	NA	Belongs to the CCSAP family.	NA	PE1	1
+NX_Q6IQ20	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	393	45596	5.71	0	Nucleoplasm;Nucleus envelope;Golgi apparatus membrane;Early endosome membrane;Cytosol	NA	Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid (PubMed:25684574, PubMed:14634025, PubMed:16527816). Responsible for the generation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (PubMed:14634025). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose (By similarity).	NA	Belongs to the NAPE-PLD family.	Biosynthesis of A2E, implicated in retinal degradation	PE1	7
+NX_Q6IQ21	Zinc finger protein 770	691	80007	9.64	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	15
+NX_Q6IQ22	Ras-related protein Rab-12	244	27248	8.68	0	Lysosome membrane;Autophagosome;Recycling endosome membrane;Golgi apparatus membrane;Cytoplasmic vesicle	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity).	Phosphorylation of Ser-106 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.	Belongs to the small GTPase superfamily. Rab family.	RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	18
+NX_Q6IQ23	Pleckstrin homology domain-containing family A member 7	1121	127135	9.39	0	Cytoplasm;Cell junction;Adherens junction;Nucleoplasm;Centrosome;Cytosol	NA	Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011).	NA	NA	NA	PE1	11
+NX_Q6IQ26	DENN domain-containing protein 5A	1287	147096	6.21	0	Cytoplasmic vesicle;Golgi apparatus;Golgi apparatus membrane	Epileptic encephalopathy, early infantile, 49	Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity).	NA	Belongs to the RAB6IP1 family.	RAB GEFs exchange GTP for GDP on RABs	PE1	11
+NX_Q6IQ32	Activity-dependent neuroprotector homeobox protein 2	1131	122833	9.3	0	Cytosol;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	18
+NX_Q6IQ49	Replication stress response regulator SDE2	451	49742	5.77	0	Golgi apparatus;Nucleus speckle;Cell membrane;Cytosol;Nucleus	NA	Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S-phase progression (PubMed:27906959).	Both SDE2-UBL and the mature SDE2 are polyubiquitinated.;The protein is cleaved at Gly-77 by a deubiquitinating enzyme to form the active SDE2.	Belongs to the SDE2 family.	NA	PE1	1
+NX_Q6IQ55	Tau-tubulin kinase 2	1244	137412	6.54	0	Centriole;Cilium;Cilium basal body;Cytosol;Nucleus	Spinocerebellar ataxia 11	Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.	NA	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.	Anchoring of the basal body to the plasma membrane	PE1	15
+NX_Q6IS14	Eukaryotic translation initiation factor 5A-1-like	154	16773	4.85	0	Cytoplasm;Endoplasmic reticulum membrane;Nucleus;Nuclear pore complex	NA	MRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).	EIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).	Belongs to the eIF-5A family.	NA	PE1	10
+NX_Q6IS24	Polypeptide N-acetylgalactosaminyltransferase 17	598	67751	9.07	1	Golgi apparatus;Nucleolus;Nucleoplasm;Golgi apparatus membrane;Nucleus	NA	May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	7
+NX_Q6ISB3	Grainyhead-like protein 2 homolog	625	71105	6.06	0	Membrane;Nucleoplasm;Nucleus	Deafness, autosomal dominant, 28;Corneal dystrophy, posterior polymorphous, 4;Ectodermal dysplasia/short stature syndrome	Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:29309642, PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293).	NA	Belongs to the grh/CP2 family. Grainyhead subfamily.	NA	PE1	8
+NX_Q6ISS4	Leukocyte-associated immunoglobulin-like receptor 2	152	16280	5.13	0	Secreted	NA	NA	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q6ISU1	Pre T-cell antigen receptor alpha	281	29266	6.58	1	Membrane	NA	The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.	NA	NA	Notch signaling pathway;NOTCH3 Intracellular Domain Regulates Transcription	PE1	6
+NX_Q6IV72	Zinc finger protein 425	752	87721	9.43	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Acts as a transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q6IWH7	Anoctamin-7	933	105532	8.11	8	Endoplasmic reticulum;Cytosol;Cell junction;Cell membrane	NA	Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22075693). May play a role in cell-cell interactions (PubMed:17308099).	NA	Belongs to the anoctamin family.	Stimuli-sensing channels	PE1	2
+NX_Q6J272	Protein FAM166A	317	36165	7.68	0	NA	NA	NA	NA	Belongs to the UPF0605 family.	NA	PE1	9
+NX_Q6J4K2	Mitochondrial sodium/calcium exchanger protein	584	64231	8.32	13	Mitochondrion inner membrane	NA	Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K(+) (PubMed:15060069).	Phosphorylation at Ser-258 by PKA prevents calcium overload.	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.	Sodium/Calcium exchangers;Mitochondrial calcium ion transport	PE1	12
+NX_Q6J9G0	Tyrosine-protein kinase STYK1	422	47577	7.1	1	Membrane;Golgi apparatus;Nucleoplasm;Cell membrane	NA	Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).	NA	Belongs to the protein kinase superfamily. Tyr protein kinase family.	NA	PE1	12
+NX_Q6JBY9	CapZ-interacting protein	416	44504	5.34	0	Cell membrane	NA	Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.	Dephosphorylation results in its dissociation from CAPZA2.;RCSD1 is phosphorylated by MAPKAPK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	1
+NX_Q6JEL2	Kelch-like protein 10	608	68942	5.47	0	Cytoplasm	Spermatogenic failure 11	May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.	NA	NA	Protein modification; protein ubiquitination.	PE1	17
+NX_Q6JQN1	Acyl-CoA dehydrogenase family member 10	1059	118834	8.33	0	NA	NA	Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA.	NA	Belongs to the acyl-CoA dehydrogenase family.	Mitochondrial Fatty Acid Beta-Oxidation	PE1	12
+NX_Q6JVE5	Epididymal-specific lipocalin-12	192	21500	5.48	0	Secreted	NA	Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity).	NA	Belongs to the calycin superfamily. Lipocalin family.	Transport of fatty acids	PE2	9
+NX_Q6JVE6	Epididymal-specific lipocalin-10	187	20759	10.36	0	Secreted	NA	May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.	NA	Belongs to the calycin superfamily. Lipocalin family.	NA	PE1	9
+NX_Q6JVE9	Epididymal-specific lipocalin-8	175	19080	6.83	0	Secreted	NA	May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.	NA	Belongs to the calycin superfamily. Lipocalin family.	NA	PE2	9
+NX_Q6K0P9	Pyrin and HIN domain-containing protein 1	492	55065	9.82	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.	NA	Belongs to the HIN-200 family.	NA	PE1	1
+NX_Q6KB66	Keratin, type II cytoskeletal 80	452	50525	5.58	0	Cytoskeleton	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q6KC79	Nipped-B-like protein	2804	316051	8.09	0	Chromosome;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	Cornelia de Lange syndrome 1	Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity).	NA	Belongs to the SCC2/Nipped-B family.	Cohesin Loading onto Chromatin	PE1	5
+NX_Q6KCM7	Calcium-binding mitochondrial carrier protein SCaMC-2	469	52663	8.54	6	Cytoplasmic vesicle;Mitochondrion inner membrane;Mitochondrion	NA	Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	9
+NX_Q6KF10	Growth/differentiation factor 6	455	50662	9.1	0	Nucleoplasm;Secreted;Nucleus membrane;Cytoplasmic vesicle	Leber congenital amaurosis 17;Multiple synostoses syndrome 4;Microphthalmia, isolated, 4;Klippel-Feil syndrome 1, autosomal dominant	Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity).	NA	Belongs to the TGF-beta family.	TGF-beta signaling pathway	PE1	8
+NX_Q6L8G4	Keratin-associated protein 5-11	156	14610	8.16	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 5 family.	Keratinization	PE1	11
+NX_Q6L8G5	Keratin-associated protein 5-10	202	17984	8.19	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 5 family.	Keratinization	PE2	11
+NX_Q6L8G8	Keratin-associated protein 5-7	165	15150	8.05	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 5 family.	Keratinization	PE2	11
+NX_Q6L8G9	Keratin-associated protein 5-6	129	11784	8.18	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 5 family.	Keratinization	PE1	11
+NX_Q6L8H1	Keratin-associated protein 5-4	288	25249	8.38	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 5 family.	Keratinization	PE1	11
+NX_Q6L8H2	Keratin-associated protein 5-3	238	22106	8.32	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 5 family.	Keratinization	PE1	11
+NX_Q6L8H4	Keratin-associated protein 5-1	278	24194	8.39	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 5 family.	Keratinization	PE2	11
+NX_Q6L8Q7	2',5'-phosphodiesterase 12	609	67352	6.11	0	Mitochondrion matrix	NA	Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:30389976, PubMed:26055709). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709).	NA	Belongs to the CCR4/nocturin family.	OAS antiviral response	PE1	3
+NX_Q6L9T8	Protein FAM72D	149	16688	6.27	0	NA	NA	NA	NA	Belongs to the FAM72 family.	NA	PE2	1
+NX_Q6L9W6	Beta-1,4-N-acetylgalactosaminyltransferase 3	998	114975	7.07	1	Golgi stack membrane;Golgi apparatus;Cytoplasmic vesicle	NA	Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa.	NA	Belongs to the chondroitin N-acetylgalactosaminyltransferase family.	NA	PE1	12
+NX_Q6MZM0	Hephaestin-like protein 1	1159	131603	6.27	1	Membrane	NA	May function as a ferroxidase and may be involved in copper transport and homeostasis.	NA	Belongs to the multicopper oxidase family.	NA	PE1	11
+NX_Q6MZM9	Proline-rich protein 27	219	22720	4.82	0	Endoplasmic reticulum;Secreted	NA	NA	NA	NA	NA	PE1	4
+NX_Q6MZN7	HLA class I histocompatibility antigen protein P5	132	14098	7.83	0	NA	NA	NA	NA	NA	NA	PE2	6
+NX_Q6MZP7	Protein lin-54 homolog	749	79494	9.22	0	Cytosol;Nucleus	NA	Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258).	NA	Belongs to the lin-54 family.	G0 and Early G1;G1/S-Specific Transcription;Polo-like kinase mediated events;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	PE1	4
+NX_Q6MZQ0	Proline-rich protein 5-like	368	40836	6.28	0	Cytosol;Cytoskeleton	NA	Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062).	Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid.	Belongs to the PROTOR family.	NA	PE1	11
+NX_Q6MZT1	Regulator of G-protein signaling 7-binding protein	257	28962	8.79	0	Cytoplasm;Cell membrane;Cytosol;Nucleus;Cytoskeleton	NA	Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation.	Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling. Upon depalmitoylation, it is targeted into the nucleus.	Belongs to the RGS7BP/RGS9BP family.	NA	PE1	5
+NX_Q6MZW2	Follistatin-related protein 4	842	93096	5.88	0	Mitochondrion;Secreted;Nucleus membrane	NA	NA	NA	NA	NA	PE1	5
+NX_Q6MZZ7	Calpain-13	669	76696	7.01	0	Nucleoplasm	NA	Probable non-lysosomal thiol-protease.	NA	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	2
+NX_Q6N021	Methylcytosine dioxygenase TET2	2002	223811	8.22	0	Nucleoplasm	Myelodysplastic syndrome;Polycythemia vera	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.	May be glycosylated. It is unclear whether interaction with OGT leads to GlcNAcylation. According to a report, it is not GlcNAcylated by OGT (PubMed:23353889). In contrast, another group reports GlcNAcylation by OGT in mouse ortholog.	Belongs to the TET family.	TET1,2,3 and TDG demethylate DNA	PE1	4
+NX_Q6N022	Teneurin-4	2769	307957	6.1	1	Cytoplasm;Cell projection;Nucleus;Cell membrane	Tremor, hereditary essential 5	Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity).	NA	Belongs to the tenascin family. Teneurin subfamily.	NA	PE1	11
+NX_Q6N043	Zinc finger protein 280D	979	109285	8.51	0	Cytoplasm;Golgi apparatus;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	May function as a transcription factor.	NA	NA	NA	PE1	15
+NX_Q6N063	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2	350	38996	5.45	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the OGFOD2 family.	NA	PE1	12
+NX_Q6N069	N-alpha-acetyltransferase 16, NatA auxiliary subunit	864	101462	8.06	0	Cytosol	NA	Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.	NA	NA	NA	PE1	13
+NX_Q6N075	Molybdate-anion transporter	450	49765	7.96	12	Golgi apparatus;Cell membrane	NA	Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.	NA	Belongs to the major facilitator superfamily.	NA	PE1	12
+NX_Q6NS38	DNA oxidative demethylase ALKBH2	261	29322	9.68	0	Nucleoplasm;Nucleus	NA	Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.	NA	Belongs to the alkB family.	ALKBH2 mediated reversal of alkylation damage	PE1	12
+NX_Q6NSI1	Putative ankyrin repeat domain-containing protein 26-like protein	321	35437	5.23	0	NA	NA	NA	NA	NA	NA	PE5	16
+NX_Q6NSI3	Protein FAM53A	398	42585	9.21	0	Nucleoplasm;Nucleus	NA	May play an important role in neural development; the dorsomedial roof of the third ventricle.	NA	Belongs to the FAM53 family.	NA	PE1	4
+NX_Q6NSI4	RPA-related protein RADX	855	97554	8.65	0	Cytoskeleton;Chromosome	NA	Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897).	NA	NA	NA	PE1	X
+NX_Q6NSI8	Uncharacterized protein KIAA1841	718	82007	6.5	0	Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the KIAA1841 family.	NA	PE1	2
+NX_Q6NSJ0	Myogenesis-regulating glycosidase	714	81087	8.6	1	Endoplasmic reticulum membrane;Nucleus membrane;Mitochondrion	Basal ganglia calcification, idiopathic, 7, autosomal recessive	Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2.	NA	Belongs to the glycosyl hydrolase 31 family.	NA	PE1	9
+NX_Q6NSJ2	Pleckstrin homology-like domain family B member 3	640	71912	6.16	0	Cytosol;Nucleus speckle;Cell membrane	NA	NA	NA	NA	NA	PE1	19
+NX_Q6NSJ5	Volume-regulated anion channel subunit LRRC8E	796	90247	6.52	4	Endoplasmic reticulum;Endoplasmic reticulum membrane;Cell membrane	NA	Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731).	NA	Belongs to the LRRC8 family.	Miscellaneous transport and binding events	PE1	19
+NX_Q6NSW5	Putative DENN domain-containing protein 10 B	357	40514	6.09	0	Late endosome	NA	May be a guanine nucleotide exchange factor (GEF).	NA	Belongs to the DENND10 family.	NA	PE5	X
+NX_Q6NSW7	Homeobox protein NANOGP8	305	34673	5.85	0	Nucleus	NA	May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation.	NA	Belongs to the Nanog homeobox family.	NA	PE2	15
+NX_Q6NSX1	Coiled-coil domain-containing protein 70	233	28767	5.7	0	Secreted;Cell membrane	NA	NA	NA	NA	NA	PE1	13
+NX_Q6NSZ9	Zinc finger and SCAN domain-containing protein 25	544	61474	7.82	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q6NT04	Tigger transposable element-derived protein 7	549	63236	8.91	0	Cytosol;Nucleus;Cell membrane	NA	NA	NA	Belongs to the tigger transposable element derived protein family.	NA	PE1	16
+NX_Q6NT16	MFS-type transporter SLC18B1	456	48869	5.15	12	Membrane;Golgi apparatus;Cytosol	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE1	6
+NX_Q6NT32	Carboxylesterase 5A	575	63926	5.98	0	Secreted	NA	Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.	N-glycosylated.	Belongs to the type-B carboxylesterase/lipase family.	Drug metabolism - other enzymes;Metabolic pathways	PE1	16
+NX_Q6NT46	G antigen 2A	116	12785	4.37	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q6NT52	Choriogonadotropin subunit beta variant 2	163	17374	8.91	0	Secreted	NA	NA	NA	Belongs to the glycoprotein hormones subunit beta family.	NA	PE2	19
+NX_Q6NT55	Cytochrome P450 4F22	531	61958	8.95	0	Microsome membrane;Endoplasmic reticulum membrane	Ichthyosis, congenital, autosomal recessive 5	NA	NA	Belongs to the cytochrome P450 family.	Miscellaneous substrates;Fatty acids;Eicosanoids;Synthesis of Leukotrienes (LT) and Eoxins (EX);Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)	PE1	19
+NX_Q6NT76	Homeobox-containing protein 1	420	47278	5.72	0	Cajal body;Cytoplasm;Nucleoplasm;Telomere;PML body;Cytosol;Nucleus	NA	Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958).	NA	NA	NA	PE1	8
+NX_Q6NT89	TMF-regulated nuclear protein 1	227	23482	11.43	0	Nucleus	NA	DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points (By similarity).	Ubiquitinated, leading to its degradation by the proteasome.	NA	NA	PE1	1
+NX_Q6NTE8	MRN complex-interacting protein	343	37743	8.98	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).	Phosphorylated; phosphorylation is constitutive and occurs in the absence of any DNA-damaging stimulus. Phosphorylation on Ser-115 is necessary for its nuclear retention.	Belongs to the MRNIP family.	NA	PE1	5
+NX_Q6NTF7	DNA dC->dU-editing enzyme APOBEC-3H	200	23532	8.84	0	Nucleoplasm;P-body;Nucleus;Cytoplasm	NA	DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	mRNA Editing: C to U Conversion;Formation of the Editosome	PE1	22
+NX_Q6NTF9	Rhomboid domain-containing protein 2	364	39202	9.48	5	Golgi apparatus;cis-Golgi network membrane	NA	NA	NA	Belongs to the peptidase S54 family.	NA	PE1	7
+NX_Q6NUI1	Putative coiled-coil domain-containing protein 144 N-terminal-like	221	23810	6.67	0	Nucleoplasm;Cell membrane	NA	NA	NA	Belongs to the CCDC144 family.	NA	PE5	17
+NX_Q6NUI2	Glycerol-3-phosphate acyltransferase 2, mitochondrial	795	87835	7.74	2	Mitochondrion outer membrane;Mitochondrion	NA	Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity.	NA	Belongs to the GPAT/DAPAT family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.;Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PA;Triglyceride biosynthesis	PE1	2
+NX_Q6NUI6	Chondroadherin-like protein	762	82388	9.2	0	Extracellular matrix;Secreted	NA	Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.	NA	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.	NA	PE1	22
+NX_Q6NUJ1	Proactivator polypeptide-like 1	521	56627	7.12	0	Cytosol;Secreted	NA	May activate the lysosomal degradation of sphingolipids.	NA	NA	Lysosome	PE1	4
+NX_Q6NUJ2	Uncharacterized protein C11orf87	197	20623	9.85	1	Membrane	NA	NA	NA	NA	NA	PE1	11
+NX_Q6NUJ5	PWWP domain-containing protein 2B	590	63967	8.52	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	10
+NX_Q6NUK1	Calcium-binding mitochondrial carrier protein SCaMC-1	477	53354	6	6	Mitochondrion inner membrane;Mitochondrion	Fontaine progeroid syndrome	Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	1
+NX_Q6NUK4	Receptor expression-enhancing protein 3	255	29264	9.57	3	Endoplasmic reticulum membrane	NA	Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.	NA	Belongs to the DP1 family.	Olfactory Signaling Pathway	PE1	10
+NX_Q6NUM6	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B	668	76946	5.86	0	NA	NA	Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).	NA	Belongs to the TYW1 family.	tRNA modification; wybutosine-tRNA(Phe) biosynthesis.	PE2	7
+NX_Q6NUM9	All-trans-retinol 13,14-reductase	610	66820	8.54	0	Endoplasmic reticulum membrane;Nucleolus	NA	Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation.	NA	Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.	Retinol metabolism;Retinoid metabolism and transport	PE1	2
+NX_Q6NUN0	Acyl-coenzyme A synthetase ACSM5, mitochondrial	579	64760	8.69	0	Cytoplasmic vesicle;Mitochondrion matrix	NA	Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism.	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Butanoate metabolism;Metabolic pathways;Conjugation of salicylate with glycine	PE1	16
+NX_Q6NUN7	Jhy protein homolog	778	88569	9.28	0	Golgi apparatus;Nucleoplasm	NA	Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces.	NA	NA	NA	PE1	11
+NX_Q6NUN9	Zinc finger protein 746	644	69136	6.41	0	Cytoplasm;Nucleus	NA	Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.	Ubiquitinated by PRKN. 'Lys-48'-linked polyubiquitination by PRKN leads to degradation by the proteasome and may play a key role in regulation of neuron death.	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q6NUP7	Serine/threonine-protein phosphatase 4 regulatory subunit 4	873	99452	7.96	0	Cytoplasm;Cytosol	NA	Putative regulatory subunit of serine/threonine-protein phosphatase 4.	NA	NA	NA	PE1	14
+NX_Q6NUQ1	RAD50-interacting protein 1	792	90632	5.29	0	Golgi apparatus;Cytoplasm;Endoplasmic reticulum membrane	NA	Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870).	NA	Belongs to the RINT1 family.	COPI-dependent Golgi-to-ER retrograde traffic	PE1	7
+NX_Q6NUQ4	Transmembrane protein 214	689	77151	9.28	2	Endoplasmic reticulum;Golgi apparatus;Cytosol;Endoplasmic reticulum membrane	NA	Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.	NA	Belongs to the TMEM214 family.	NA	PE1	2
+NX_Q6NUR6	Putative protein RNF216-like	42	5133	5.4	0	NA	NA	NA	NA	NA	NA	PE5	7
+NX_Q6NUS6	Tectonic-3	607	66157	8.6	1	Membrane;Endoplasmic reticulum;Cytoskeleton	Orofaciodigital syndrome 4;Joubert syndrome 18	Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.	NA	Belongs to the tectonic family.	Anchoring of the basal body to the plasma membrane	PE1	10
+NX_Q6NUS8	UDP-glucuronosyltransferase 3A1	523	59151	8.2	1	Membrane;Cytoplasmic vesicle;Cytosol	NA	UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).	NA	Belongs to the UDP-glycosyltransferase family.	Glucuronidation	PE1	5
+NX_Q6NUT2	Probable C-mannosyltransferase DPY19L2	758	87374	9.24	11	Membrane;Nucleoplasm;Mitochondrion	Spermatogenic failure 9	Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation.	NA	Belongs to the dpy-19 family.	NA	PE1	12
+NX_Q6NUT3	Major facilitator superfamily domain-containing protein 12	480	52075	8.67	12	Membrane;Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE1	19
+NX_Q6NV74	Uncharacterized protein KIAA1211-like	962	102157	8.14	0	Centrosome;Cytoskeleton	NA	NA	NA	NA	NA	PE1	2
+NX_Q6NV75	Probable G-protein coupled receptor 153	609	65361	7.9	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	1
+NX_Q6NVH7	ATPase SWSAP1	229	24311	5.09	0	Nucleus	NA	ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity.	NA	NA	NA	PE1	19
+NX_Q6NVU6	Inactive Ufm1-specific protease 1	142	15060	5.9	0	NA	NA	NA	NA	Belongs to the peptidase C78 family.	NA	PE1	7
+NX_Q6NVV0	Putative makorin-5	33	3805	3.31	0	NA	NA	NA	NA	NA	NA	PE5	12
+NX_Q6NVV1	Putative 60S ribosomal protein L13a protein RPL13AP3	102	12135	10.76	0	NA	NA	NA	NA	Belongs to the universal ribosomal protein uL13 family.	NA	PE5	14
+NX_Q6NVV3	Magnesium transporter NIPA3	410	44638	5.68	9	Membrane;Golgi apparatus	NA	Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).	NA	Belongs to the NIPA family.	Miscellaneous transport and binding events	PE1	4
+NX_Q6NVV7	Cysteine-rich DPF motif domain-containing protein 1	123	13877	8.34	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the CDPF1 family.	NA	PE1	22
+NX_Q6NVV9	Putative disintegrin and metalloproteinase domain-containing protein 5	412	47181	6.34	0	NA	NA	This is a non catalytic metalloprotease-like protein.	NA	NA	NA	PE5	8
+NX_Q6NVY1	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	386	43482	8.38	0	Nucleoplasm;Mitochondrion	3-hydroxyisobutryl-CoA hydrolase deficiency	Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.	NA	Belongs to the enoyl-CoA hydratase/isomerase family.	Amino-acid degradation; L-valine degradation.;Valine, leucine and isoleucine degradation;beta-Alanine metabolism;Propanoate metabolism;Metabolic pathways;Branched-chain amino acid catabolism	PE1	2
+NX_Q6NW29	RWD domain-containing protein 4	188	21251	5.24	0	Cytoskeleton	NA	NA	NA	NA	NA	PE1	4
+NX_Q6NW34	Nucleolus and neural progenitor protein	567	64552	9.79	0	Nucleoplasm;Nucleolus;Nucleus	NA	May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.	NA	Belongs to the nepro family.	NA	PE1	3
+NX_Q6NW40	RGM domain family member B	437	47547	5.92	0	Nucleoplasm;Membrane raft;Cell membrane	NA	Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.	GPI-anchored.;Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.	Belongs to the repulsive guidance molecule (RGM) family.	Netrin-1 signaling	PE1	5
+NX_Q6NWY9	Pre-mRNA-processing factor 40 homolog B	871	99358	6.39	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleus	NA	May be involved in pre-mRNA splicing.	NA	Belongs to the PRPF40 family.	NA	PE1	12
+NX_Q6NX45	Zinc finger protein 774	483	55068	8.72	0	Cytosol;Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	15
+NX_Q6NX49	Zinc finger protein 544	715	81742	8.15	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6NXE6	Armadillo repeat-containing protein 6	501	54142	5.83	0	Cytosol	NA	NA	NA	Belongs to the ARMC6 family.	NA	PE1	19
+NX_Q6NXG1	Epithelial splicing regulatory protein 1	681	75585	6.24	0	Nucleoplasm;Nucleus	Deafness, autosomal recessive, 109	MRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity).	NA	Belongs to the ESRP family.	FGFR2 alternative splicing;Signaling by BRAF and RAF fusions	PE1	8
+NX_Q6NXN4	Putative C-mannosyltransferase DPY19L2P1	242	28036	9.85	3	Membrane	NA	Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.	NA	Belongs to the dpy-19 family.	NA	PE2	7
+NX_Q6NXP0	EF-hand calcium-binding domain-containing protein 12	572	66551	9.51	0	Nucleoplasm;Nucleus;Midbody ring	NA	NA	NA	NA	NA	PE1	3
+NX_Q6NXP2	Protein FAM71F2	309	34516	6.15	0	Nucleoplasm	NA	NA	NA	Belongs to the FAM71 family.	NA	PE1	7
+NX_Q6NXP6	NADP-dependent oxidoreductase domain-containing protein 1	359	39880	6.2	0	NA	NA	Probable oxidoreductase.	NA	Belongs to the pyrroline-5-carboxylate reductase family.	NA	PE1	14
+NX_Q6NXR0	Interferon-inducible GTPase 5	463	50288	5.22	0	NA	NA	NA	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.	NA	PE1	19
+NX_Q6NXR4	TELO2-interacting protein 2	508	56915	6.63	0	Centrosome	Mental retardation, autosomal recessive 39	Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.	NA	Belongs to the TTI2 family.	NA	PE1	8
+NX_Q6NXS1	Protein phosphatase inhibitor 2 family member B	205	23106	4.77	0	NA	NA	Inhibitor of protein-phosphatase 1.	NA	Belongs to the protein phosphatase inhibitor 2 family.	NA	PE1	5
+NX_Q6NXT1	Ankyrin repeat domain-containing protein 54	300	32505	5.84	0	Cytoplasm;Nucleoplasm;Midbody;Nucleus;Cytoskeleton	NA	Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.	NA	NA	NA	PE1	22
+NX_Q6NXT2	Histone H3.3C	135	15214	11.11	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.	Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.;Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-122 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).;Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression (By similarity).;Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).;Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).;Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-41 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).;Methylation at Lys-5 (H3K4me) is linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) requires preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-56 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication (By similarity).;Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.	Belongs to the histone H3 family.	Systemic lupus erythematosus	PE1	12
+NX_Q6NXT4	Zinc transporter 6	461	51116	9.28	6	Golgi apparatus;trans-Golgi network membrane	NA	Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.	NA	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.	Insulin processing;Zinc efflux and compartmentalization by the SLC30 family	PE1	2
+NX_Q6NXT6	Transmembrane anterior posterior transformation protein 1 homolog	567	64260	8.56	5	Membrane;Cytoplasmic vesicle;Centrosome;Cilium basal body	Osteochondrodysplasia, complex lethal, Symoens-Barnes-Gistelinck type	(Microbial infection) In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169.;Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity).	NA	Belongs to the TAPT1 family.	NA	PE1	4
+NX_Q6NY19	KN motif and ankyrin repeat domain-containing protein 3	840	88425	5.17	0	Cell membrane	NA	May be involved in the control of cytoskeleton formation by regulating actin polymerization.	NA	NA	NA	PE1	19
+NX_Q6NYC1	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6	403	46462	8.84	0	Cytoplasm;Nucleoplasm;Nucleolus	NA	Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:24498420, PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24498420, PubMed:24360279). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002).	Hydroxylates its own N-terminus; hydroxylation is required for homooligomerization.	Belongs to the JMJD6 family.	HDMs demethylate histones	PE1	17
+NX_Q6NYC8	Phostensin	613	67943	5.38	0	Nucleoplasm;Cell membrane;Cytoskeleton	NA	May target protein phosphatase 1 to F-actin cytoskeleton.;May target protein phosphatase 1 to F-actin cytoskeleton.	NA	NA	NA	PE1	6
+NX_Q6NZ36	Fanconi anemia core complex-associated protein 20	180	19869	6.9	0	Nucleoplasm;Cell junction;Nucleus;Chromosome	NA	Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.	NA	NA	Fanconi Anemia Pathway	PE1	1
+NX_Q6NZ63	STEAP family member 1B	245	28815	8.82	4	Membrane	NA	NA	NA	Belongs to the STEAP family.	NA	PE2	7
+NX_Q6NZ67	Mitotic-spindle organizing protein 2B	158	16226	10.16	0	Cytoplasm;Spindle;Centrosome	NA	NA	NA	Belongs to the MOZART2 family.	Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes	PE1	2
+NX_Q6NZI2	Caveolae-associated protein 1	390	43476	5.51	0	Mitochondrion;Microsome;Cell membrane;Endoplasmic reticulum;Caveola;Cytoplasmic vesicle;Cytosol;Nucleus	Congenital generalized lipodystrophy 4	Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity).	Monoubiquitinated.;Five truncated forms are found in the caveolae. These are thought to be the result of proteolysis and may be phosphorylation-dependent.;Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity. Phosphorylation at Tyr-156 is essential for its functionin the regulation of ribosomal transcriptional activity.	Belongs to the CAVIN family.	RNA Polymerase I Transcription Termination	PE1	17
+NX_Q6NZY4	Zinc finger CCHC domain-containing protein 8	707	78577	4.8	0	Nucleoplasm;Nucleus	NA	Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). May be involved in pre-mRNA splicing (Probable).	Phosphorylation at Thr-492 by GSK3 is triggered in cells entering mitosis; this phosphorylation is greatly enhanced by nocodazole treatment, but reduced by lithium.	Belongs to the ZCCHC8 family.	NA	PE1	12
+NX_Q6NZY7	Cdc42 effector protein 5	148	15207	6.9	0	Endomembrane system;Cytoskeleton	NA	Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity).	NA	Belongs to the BORG/CEP family.	MAPK6/MAPK4 signaling	PE1	19
+NX_Q6P047	Uncharacterized protein C8orf74	294	33735	7.74	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	8
+NX_Q6P050	F-box and leucine-rich protein 22	247	27269	9.99	0	Cytosol;Z line;Nucleolus	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	15
+NX_Q6P087	Mitochondrial mRNA pseudouridine synthase RPUSD3	351	38461	10.33	0	Nucleoplasm;Mitochondrion matrix	NA	Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis (PubMed:27667664).	NA	Belongs to the pseudouridine synthase RluA family.	NA	PE1	3
+NX_Q6P093	Arylacetamide deacetylase-like 2	401	46099	7.2	0	Secreted	NA	NA	NA	Belongs to the 'GDXG' lipolytic enzyme family.	NA	PE2	3
+NX_Q6P0A1	Protein FAM180B	183	20302	4.74	0	Secreted	NA	NA	NA	Belongs to the FAM180 family.	NA	PE1	11
+NX_Q6P0N0	Mis18-binding protein 1	1132	129085	9.31	0	Nucleolus;Chromosome;Centromere;Cytosol;Nucleus	NA	Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.	NA	NA	Deposition of new CENPA-containing nucleosomes at the centromere	PE1	14
+NX_Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	1798	196436	8.41	0	Cytosol;Cytoskeleton;Cell membrane	NA	Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).	Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination (By similarity).	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	NA	PE1	1
+NX_Q6P158	Putative ATP-dependent RNA helicase DHX57	1386	155604	7.83	0	Cytosol;Nucleolus;Cytoskeleton	NA	Probable ATP-binding RNA helicase.	NA	Belongs to the DEAD box helicase family. DEAH subfamily.	NA	PE1	2
+NX_Q6P161	39S ribosomal protein L54, mitochondrial	138	15819	9.6	0	Mitochondrion	NA	NA	NA	NA	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	19
+NX_Q6P179	Endoplasmic reticulum aminopeptidase 2	960	110462	6.25	1	Golgi apparatus;Endoplasmic reticulum membrane	NA	Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.	N-glycosylated.	Belongs to the peptidase M1 family.	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	PE1	5
+NX_Q6P1A2	Lysophospholipid acyltransferase 5	487	56035	8.88	9	Endoplasmic reticulum membrane	NA	Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.	NA	Belongs to the membrane-bound acyltransferase family.	Lipid metabolism; phospholipid metabolism.;Glycerophospholipid metabolism;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE	PE1	12
+NX_Q6P1J6	Phospholipase B1, membrane-associated	1458	163081	5.57	1	Apical cell membrane	NA	Membrane-associated phospholipase. Exhibits a calcium-independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity).	Undergoes proteolytic cleavage in the ileum.	Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;Vitamin digestion and absorption;Retinoid metabolism and transport;Acyl chain remodelling of PC	PE1	2
+NX_Q6P1J9	Parafibromin	531	60577	9.63	0	Nucleoplasm;Cytosol;Nucleus	Hyperparathyroidism 2 with jaw tumors;Hyperparathyroidism 1;Parathyroid carcinoma	Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors.	Phosphorylated. Dephosphorylated by PTPN11.	Belongs to the CDC73 family.	Hedgehog 'on' state;Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;Formation of the beta-catenin:TCF transactivating complex;E3 ubiquitin ligases ubiquitinate target proteins	PE1	1
+NX_Q6P1K1	Heme transporter HRG1	146	16419	9.66	4	Cytoplasmic vesicle;Lysosome membrane;Endosome membrane	NA	Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.	NA	Belongs to the HRG family.	NA	PE1	12
+NX_Q6P1K2	Polyamine-modulated factor 1	205	23339	5.39	0	Kinetochore;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.	NA	NA	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	1
+NX_Q6P1K8	General transcription factor IIH subunit 2-like protein	395	44452	6.13	0	Nucleus	NA	Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.	NA	Belongs to the GTF2H2 family.	Basal transcription factors;Nucleotide excision repair;Basal transcription factors;Nucleotide excision repair	PE1	5
+NX_Q6P1L5	Protein FAM117B	589	61968	9.86	0	Nucleoplasm;Centrosome	NA	NA	NA	NA	NA	PE1	2
+NX_Q6P1L6	Zinc finger protein 343	599	69220	9.19	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	20
+NX_Q6P1L8	39S ribosomal protein L14, mitochondrial	145	15948	10.26	0	Mitochondrion	NA	Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).	NA	Belongs to the universal ribosomal protein uL14 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	6
+NX_Q6P1M0	Long-chain fatty acid transport protein 4	643	72064	8.77	2	Membrane;Cytoplasmic vesicle;Endoplasmic reticulum membrane	Ichthyosis prematurity syndrome	Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	PPAR signaling pathway;Fat digestion and absorption;Transport of fatty acids;Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)	PE1	9
+NX_Q6P1M3	LLGL scribble cell polarity complex component 2	1020	113448	7.22	0	Cytoplasmic vesicle;Cytosol;Cytoplasm	NA	Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.	Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex.	Belongs to the WD repeat L(2)GL family.	Tight junction	PE1	17
+NX_Q6P1M9	Armadillo repeat-containing X-linked protein 5	558	62346	8.85	0	Cytosol;Nucleus speckle;Cell membrane	NA	NA	NA	Belongs to the eutherian X-chromosome-specific Armcx family.	NA	PE1	X
+NX_Q6P1N0	Coiled-coil and C2 domain-containing protein 1A	951	104062	8.22	0	Cytoplasm;Cell membrane;Nucleolus;Centrosome;Cytosol;Nucleus	Mental retardation, autosomal recessive 3	Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.	Phosphorylation on Ser-208 by CDK1 promotes spindle pole localization and association with SCC1/RAD21.	Belongs to the CC2D1 family.	NA	PE1	19
+NX_Q6P1N9	Putative deoxyribonuclease TATDN1	297	33602	6.51	0	Nucleoplasm;Nucleus	NA	Putative deoxyribonuclease.	NA	Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.	NA	PE1	8
+NX_Q6P1Q0	LETM1 domain-containing protein 1	360	41790	10.32	1	Mitochondrion outer membrane;Nucleoplasm;Mitochondrion;Nucleolus	NA	Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.	NA	NA	NA	PE1	12
+NX_Q6P1Q9	tRNA N(3)-methylcytidine methyltransferase METTL2B	378	43426	5.59	0	NA	NA	S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU).	NA	Belongs to the methyltransferase superfamily. METL family.	Histidine metabolism;Tyrosine metabolism	PE1	7
+NX_Q6P1R3	Myb/SANT-like DNA-binding domain-containing protein 2	559	61319	5.86	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	11
+NX_Q6P1R4	tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like	473	53230	8.65	0	Cell membrane	NA	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.	NA	Belongs to the Dus family. Dus1 subfamily.	NA	PE1	17
+NX_Q6P1S2	Protein C3orf33	294	33765	9.85	1	Membrane;Nucleoplasm;Cytosol;Secreted	NA	Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.	NA	NA	NA	PE1	3
+NX_Q6P1W5	Uncharacterized protein C1orf94	598	65353	8.56	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q6P1X5	Transcription initiation factor TFIID subunit 2	1199	136971	8.45	0	Nucleus	Mental retardation, autosomal recessive 40	Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.	NA	Belongs to the TAF2 family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation	PE1	8
+NX_Q6P1X6	UPF0598 protein C8orf82	216	23889	9.36	0	Nucleoplasm	NA	NA	NA	Belongs to the UPF0598 family.	NA	PE1	8
+NX_Q6P280	Zinc finger protein 529	563	65865	8.54	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6P2C0	WD repeat-containing protein 93	686	77378	5.99	0	Cytoskeleton	NA	NA	NA	NA	NA	PE1	15
+NX_Q6P2C8	Mediator of RNA polymerase II transcription subunit 27	311	35432	9.37	0	Nucleus;Nucleoplasm;Cytosol;Nucleolus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 27 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	9
+NX_Q6P2D0	Zinc finger protein 1 homolog	407	47516	8.85	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_Q6P2D8	X-ray radiation resistance-associated protein 1	792	89864	9.06	0	Nucleoplasm;Cytoplasm;Nucleus	NA	May be involved in the response of cells to X-ray radiation.	NA	NA	NA	PE1	11
+NX_Q6P2E9	Enhancer of mRNA-decapping protein 4	1401	151661	5.55	0	Nucleoplasm;Cytosol;P-body;Nucleus	NA	In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).	NA	Belongs to the WD repeat EDC4 family.	RNA degradation;mRNA decay by 5' to 3' exoribonuclease	PE1	16
+NX_Q6P2H3	Centrosomal protein of 85 kDa	762	85639	5.68	0	Golgi apparatus;Nucleolus;Spindle pole;Centrosome;Cytosol	NA	Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856).	NA	Belongs to the CEP85 family.	NA	PE1	1
+NX_Q6P2H8	Transmembrane protein 53	277	31630	8.81	1	Membrane;Golgi apparatus;Focal adhesion	NA	NA	NA	Belongs to the TMEM53 family.	NA	PE1	1
+NX_Q6P2I3	Fumarylacetoacetate hydrolase domain-containing protein 2B	314	34613	7.64	0	NA	NA	May have hydrolase activity.	NA	Belongs to the FAH family.	NA	PE1	2
+NX_Q6P2I7	Endogenous Bornavirus-like nucleoprotein 2	272	30450	9.2	0	Nucleoplasm;Nucleus	NA	May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human.	NA	NA	NA	PE2	3
+NX_Q6P2M8	Calcium/calmodulin-dependent protein kinase type 1B	343	38500	6.28	0	Golgi apparatus;Cytoplasm;Cell membrane;Cytosol;Nucleus	NA	Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).	Phosphorylated by CAMKK1.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	NA	PE1	X
+NX_Q6P2P2	Protein arginine N-methyltransferase 9	845	94501	5.12	0	Nucleoplasm;Cytosol;Cytoplasm;Cytoskeleton	NA	Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	NA	PE1	4
+NX_Q6P2Q9	Pre-mRNA-processing-splicing factor 8	2335	273600	8.95	0	Nucleoplasm;Nucleus speckle;Nucleus	Retinitis pigmentosa 13	Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.	NA	NA	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	17
+NX_Q6P2S7	Putative tetratricopeptide repeat protein 41	1318	151684	8.53	0	Cytoplasm	NA	NA	NA	NA	NA	PE5	12
+NX_Q6P387	Uncharacterized protein C16orf46	395	43418	8.79	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE2	16
+NX_Q6P3R8	Serine/threonine-protein kinase Nek5	708	81445	9.05	0	NA	NA	NA	NA	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	NA	PE1	13
+NX_Q6P3S1	DENN domain-containing protein 1B	775	86552	5.54	0	Clathrin-coated vesicle;Cytosol;Nucleus speckle	Asthma	Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822).	Phosphorylated on serine and/or threonine, possibly regulating the guanine nucleotide exchange factor (GEF) activity.	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	1
+NX_Q6P3S6	F-box only protein 42	717	77839	7.07	0	Nucleoplasm	NA	Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.	NA	NA	NA	PE1	1
+NX_Q6P3V2	Zinc finger protein 585A	769	87974	9.26	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6P3W2	DnaJ homolog subfamily C member 24	149	17139	4.53	0	Cytosol;Cytoskeleton	NA	Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).	NA	Belongs to the DPH4 family.	Protein modification; peptidyl-diphthamide biosynthesis.;Synthesis of diphthamide-EEF2	PE1	11
+NX_Q6P3W6	Neuroblastoma breakpoint family member 10	841	96426	4.63	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE1	1
+NX_Q6P3W7	SCY1-like protein 2	929	103709	8.45	0	Clathrin-coated vesicle;trans-Golgi network membrane;Perinuclear region;Endosome membrane	NA	Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system.	According to PubMed:15809293, autophosphorylated in presence of poly-L-lysine.	Belongs to the protein kinase superfamily.	NA	PE1	12
+NX_Q6P3X3	Tetratricopeptide repeat protein 27	843	96632	5.42	0	Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the TTC27 family.	NA	PE1	2
+NX_Q6P3X8	PiggyBac transposable element-derived protein 2	592	68011	8.82	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	1
+NX_Q6P435	Putative uncharacterized SMG1-like protein	159	17652	9.6	0	NA	NA	NA	NA	NA	NA	PE5	16
+NX_Q6P444	Mitochondrial fission regulator 2	385	43384	6.53	0	Cytoplasmic vesicle;Mitochondrion	NA	May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity).	NA	Belongs to the MTFR1 family.	NA	PE1	6
+NX_Q6P461	Acyl-coenzyme A synthetase ACSM6, mitochondrial	480	53585	8.73	0	Mitochondrion	NA	Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism.	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Beta oxidation of butanoyl-CoA to acetyl-CoA	PE2	10
+NX_Q6P474	Putative pyridoxal-dependent decarboxylase domain-containing protein 2	469	51810	5.65	0	NA	NA	NA	NA	Belongs to the group II decarboxylase family.	NA	PE5	16
+NX_Q6P499	NIPA-like protein 3	406	44742	8.1	9	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the NIPA family.	Miscellaneous transport and binding events	PE1	1
+NX_Q6P4A7	Sideroflexin-4	337	37998	9.3	5	Mitochondrion inner membrane	Combined oxidative phosphorylation deficiency 18	Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (PubMed:30442778).	NA	Belongs to the sideroflexin family.	NA	PE1	10
+NX_Q6P4A8	Phospholipase B-like 1	553	63255	9.11	0	Lysosome	NA	In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.	The maturation cleavages that produces chains A and B are required to open the putative substrate binding pocket. Both chains A and B remain associated in the mature protein.	Belongs to the phospholipase B-like family.	Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC	PE1	12
+NX_Q6P4D5	Protein FAM122C	195	22522	9.92	0	Nucleoplasm	NA	NA	NA	Belongs to the FAM122 family.	NA	PE1	X
+NX_Q6P4E1	Protein CASC4	436	49498	5.14	1	Membrane;Golgi apparatus	NA	NA	NA	Belongs to the GOLM1/CASC4 family.	NA	PE1	15
+NX_Q6P4F1	Alpha-(1,3)-fucosyltransferase 10	479	56094	8.62	1	Golgi stack membrane;Endoplasmic reticulum;Nucleoplasm;Golgi apparatus	NA	Probable fucosyltransferase.	NA	Belongs to the glycosyltransferase 10 family.	Protein modification; protein glycosylation.;Lewis blood group biosynthesis	PE1	8
+NX_Q6P4F2	Ferredoxin-2, mitochondrial	186	19888	5.31	0	Mitochondrion matrix;Mitochondrion	Mitochondrial myopathy, episodic, with optic atrophy and reversible leukoencephalopathy	Essential for heme A and Fe/S protein biosynthesis.	NA	Belongs to the adrenodoxin/putidaredoxin family.	Mitochondrial iron-sulfur cluster biogenesis;Pregnenolone biosynthesis;Endogenous sterols;Electron transport from NADPH to Ferredoxin;Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	PE1	19
+NX_Q6P4F7	Rho GTPase-activating protein 11A	1023	113866	9.19	0	Cytosol;Nucleolus	NA	NA	NA	NA	Rho GTPase cycle	PE1	15
+NX_Q6P4H8	ATP synthase subunit C lysine N-methyltransferase	233	26110	9.04	1	Cytoplasm;Cell membrane;Nucleoplasm;Mitochondrion membrane;Cytoplasmic vesicle	NA	Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090).	NA	Belongs to the ANT/ATPSC lysine N-methyltransferase family.	NA	PE1	5
+NX_Q6P4I2	WD repeat-containing protein 73	378	41685	5.46	0	Spindle pole;Spindle;Cleavage furrow;Cytosol	Galloway-Mowat syndrome 1	May play a role in the regulation of microtubule organization and dynamics (PubMed:25466283).	NA	Belongs to the WD repeat WDR73 family.	NA	PE1	15
+NX_Q6P4Q7	Metal transporter CNNM4	775	86607	5.75	3	Cytoskeleton;Cell membrane	Jalili syndrome	Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function.	NA	Belongs to the ACDP family.	NA	PE1	2
+NX_Q6P4R8	Nuclear factor related to kappa-B-binding protein	1299	139001	9.29	0	Nucleoplasm;Nucleus	NA	Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.;Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.	NA	Belongs to the NFRKB family.	DNA Damage Recognition in GG-NER;UCH proteinases	PE1	11
+NX_Q6P531	Glutathione hydrolase 6	493	50509	5.66	1	Membrane	NA	Cleaves glutathione conjugates.	NA	Belongs to the gamma-glutamyltransferase family.	Sulfur metabolism; glutathione metabolism.;Taurine and hypotaurine metabolism;Cyanoamino acid metabolism;Glutathione metabolism;Arachidonic acid metabolism;Metabolic pathways;Aflatoxin activation and detoxification;Glutathione synthesis and recycling	PE1	17
+NX_Q6P575	Putative inactive beta-glucuronidase protein GUSBP11	273	29908	6.54	0	NA	NA	NA	NA	Belongs to the glycosyl hydrolase 2 family.	NA	PE5	22
+NX_Q6P582	Mitotic-spindle organizing protein 2A	158	16221	9.66	0	Cytoplasm;Spindle;Centrosome	NA	NA	NA	Belongs to the MOZART2 family.	Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes	PE1	2
+NX_Q6P587	Acylpyruvase FAHD1, mitochondrial	224	24843	6.96	0	Nucleoplasm;Cytosol;Mitochondrion	NA	Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (PubMed:15551868, PubMed:21878618). Also has oxaloacetate decarboxylase activity (PubMed:25575590).	NA	Belongs to the FAH family.	Citric acid cycle (TCA cycle)	PE1	16
+NX_Q6P589	Tumor necrosis factor alpha-induced protein 8-like protein 2	184	20556	8.54	0	Cytoplasmic vesicle	NA	Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).	NA	Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.	PI Metabolism	PE1	1
+NX_Q6P597	Kinesin light chain 3	504	55364	6.06	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.	NA	Belongs to the kinesin light chain family.	Salmonella infection;MHC class II antigen presentation;Kinesins;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic	PE1	19
+NX_Q6P5Q4	Leiomodin-2	547	61675	5.63	0	Cytoskeleton;Myofibril;M line;Sarcomere	NA	Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:26370058, PubMed:25250574, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713).	NA	Belongs to the tropomodulin family.	NA	PE1	7
+NX_Q6P5R6	60S ribosomal protein L22-like 1	122	14607	9.37	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL22 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	3
+NX_Q6P5S2	Protein LEG1 homolog	330	37926	5.78	0	Secreted	NA	May be involved in early liver development.	NA	Belongs to the LEG1 family.	NA	PE1	6
+NX_Q6P5S7	Ribonuclease kappa	137	15420	9.21	2	Membrane	NA	(Microbial infection) Required for the initial stages of clathrin-mediated endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, and influenza viruses (PubMed:26056282). Not required for clathrin-mediated endocytosis and macropinocytosis (PubMed:26056282).;Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.	NA	Belongs to the RNase K family.	NA	PE1	17
+NX_Q6P5W5	Zinc transporter ZIP4	647	68408	5.27	6	Recycling endosome membrane;Cell membrane	Acrodermatitis enteropathica, zinc-deficiency type	Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity).	NA	Belongs to the ZIP transporter (TC 2.A.5) family.	Zinc influx into cells by the SLC39 gene family;Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)	PE1	8
+NX_Q6P5X5	UPF0545 protein C22orf39	142	16805	8.22	0	Endoplasmic reticulum	NA	NA	NA	Belongs to the UPF0545 family.	NA	PE1	22
+NX_Q6P5X7	Transmembrane protein 71	295	32983	6.06	2	Membrane;Mitochondrion	NA	NA	NA	Belongs to the TMEM71 family.	NA	PE2	8
+NX_Q6P5Z2	Serine/threonine-protein kinase N3	889	99421	8.77	0	Cytoplasmic vesicle;Perinuclear region;Nucleus	NA	Contributes to invasiveness in malignant prostate cancer.	Autophosphorylated.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Salmonella infection;RHO GTPases activate PKNs	PE1	9
+NX_Q6P656	Cilia- and flagella-associated protein 161	301	34294	5.84	0	NA	NA	May play a role in motile cilia function, possibly by acting on dynein arm assembly.	NA	NA	NA	PE1	15
+NX_Q6P6B1	Glutamate-rich protein 5	374	39936	4.46	0	Nucleoplasm;Golgi apparatus;Cytosol	NA	NA	NA	NA	NA	PE1	8
+NX_Q6P6B7	Ankyrin repeat domain-containing protein 16	361	39284	6.82	0	Endoplasmic reticulum;Cytoplasm;Nucleus	NA	Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides.	NA	NA	NA	PE1	10
+NX_Q6P6C2	RNA demethylase ALKBH5	394	44256	9.19	0	Golgi apparatus;Nucleoplasm;Nucleus speckle;Cytosol	NA	Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity).	NA	Belongs to the alkB family.	Reversal of alkylation damage by DNA dioxygenases	PE1	17
+NX_Q6P7N7	Transmembrane protein 81	255	28468	8.92	1	Membrane;Cytoskeleton	NA	NA	NA	NA	NA	PE2	1
+NX_Q6P988	Palmitoleoyl-protein carboxylesterase NOTUM	496	55699	7.52	0	Secreted	NA	Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).	NA	Belongs to the pectinacetylesterase family. Notum subfamily.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Release of Hh-Np from the secreting cell;Post-translational protein phosphorylation	PE1	17
+NX_Q6P995	Protein FAM171B	826	92181	8.79	1	Membrane;Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the FAM171 family.	NA	PE1	2
+NX_Q6P996	Pyridoxal-dependent decarboxylase domain-containing protein 1	788	86707	5.25	0	NA	NA	NA	NA	Belongs to the group II decarboxylase family.	NA	PE1	16
+NX_Q6P9A1	Zinc finger protein 530	599	68837	9.01	0	Cytoplasmic vesicle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6P9A2	Polypeptide N-acetylgalactosaminyltransferase 18	607	69561	6.07	1	Mitochondrion;Golgi apparatus membrane	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	11
+NX_Q6P9A3	Zinc finger protein 549	640	74439	8.88	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6P9B6	MTOR-associated protein MEAK7	456	50994	5.81	0	Cytoplasm;Nucleolus;Membrane;Nucleoplasm;Lysosome;Cytosol	NA	Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193).	NA	NA	NA	PE1	16
+NX_Q6P9B9	Integrator complex subunit 5	1019	107995	6.58	3	Cytoplasm;Nucleus membrane;Nucleoplasm;Cytosol;Nucleus	NA	Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).	NA	Belongs to the Integrator subunit 5 family.	RNA polymerase II transcribes snRNA genes	PE1	11
+NX_Q6P9F0	Coiled-coil domain-containing protein 62	684	77748	5.73	0	Cytoplasm;Nucleoplasm;Nucleus;Cell membrane	NA	Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.	NA	NA	NA	PE1	12
+NX_Q6P9F5	Tripartite motif-containing protein 40	258	29336	7.54	0	NA	NA	May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.	NA	Belongs to the TRIM/RBCC family.	NA	PE1	6
+NX_Q6P9F7	Volume-regulated anion channel subunit LRRC8B	803	92390	6.4	4	Nucleus speckle;Endoplasmic reticulum membrane;Cell membrane	NA	Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731).	NA	Belongs to the LRRC8 family.	Miscellaneous transport and binding events	PE1	1
+NX_Q6P9G0	Cytochrome b5 domain-containing protein 1	228	26689	5.37	0	Golgi apparatus;Nucleolus	NA	NA	NA	Belongs to the cytochrome b5 family.	NA	PE1	17
+NX_Q6P9G4	Transmembrane protein 154	183	20498	4.5	1	Membrane;Nucleoplasm;Nucleus membrane	NA	NA	NA	NA	NA	PE1	4
+NX_Q6P9G9	Zinc finger protein 449	518	59932	6.96	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	X
+NX_Q6P9H4	Connector enhancer of kinase suppressor of ras 3	555	61904	8.94	0	Cytoplasm;Cytosol;Mitochondrion;Apical cell membrane	NA	Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).	NA	Belongs to the CNKSR family.	NA	PE1	6
+NX_Q6P9H5	GTPase IMAP family member 6	292	32949	4.86	0	Cytosol	NA	NA	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.	NA	PE1	7
+NX_Q6PB30	Putative chondrosarcoma-associated gene 1 protein	78	8697	10.94	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_Q6PCB0	von Willebrand factor A domain-containing protein 1	445	46804	7.18	0	Basement membrane	NA	Promotes matrix assembly.	N-glycosylated.	NA	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	1
+NX_Q6PCB5	Lysine-specific demethylase RSBN1L	846	94870	8.91	0	Nucleus speckle;Nucleus;Cell membrane	NA	Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins.	NA	Belongs to the round spermatid basic protein 1 family.	NA	PE1	7
+NX_Q6PCB6	Alpha/beta hydrolase domain-containing protein 17C	329	35831	5.42	0	Postsynaptic density;Dendritic spine;Recycling endosome membrane	NA	Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95.	Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.	Belongs to the AB hydrolase superfamily. ABHD17 family.	NA	PE1	15
+NX_Q6PCB7	Long-chain fatty acid transport protein 1	646	71108	8.83	1	Cytoplasm;Mitochondrion;Cell membrane;Endomembrane system;Cytosol	NA	Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane (PubMed:28178239). Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	PPAR signaling pathway;PPARA activates gene expression;Transport of fatty acids	PE1	19
+NX_Q6PCB8	Embigin	327	36881	6.13	1	Synapse;Cell membrane	NA	Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity).	NA	NA	Proton-coupled monocarboxylate transport	PE1	5
+NX_Q6PCD5	E3 ubiquitin-protein ligase RFWD3	774	85094	6.02	0	Cytoplasm;Nucleoplasm;PML body;Cytosol;Nucleus	Fanconi anemia, complementation group W	E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658). Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929). Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658). Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098). May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098). In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 (PubMed:20173098).	Phosphorylated at Ser-46 and Ser-63 upon DNA damage by ATM or ATR. ATM phosphorylation occurs at early times upon DNA damage, while ATR is the major kinase at later times. Phosphorylation by ATM and ATR is required to stabilize p53/TP53. Part of the phosphorylation depends upon RPA2 presence.	NA	Protein modification; protein ubiquitination.	PE1	16
+NX_Q6PCE3	Glucose 1,6-bisphosphate synthase	622	70442	6.81	0	Mitochondrion	NA	Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars as acceptors, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate. 5 or 6-phosphosugars are bad substrates, with the exception of glucose 6-phosphate. Also synthesizes ribose 1,5-bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities.	NA	Belongs to the phosphohexose mutase family.	Starch and sucrose metabolism;Glycolysis;Glycogen synthesis;Glycogen breakdown (glycogenolysis);Galactose catabolism	PE1	11
+NX_Q6PCT2	F-box/LRR-repeat protein 19	694	75707	9.44	0	Cytoskeleton	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	16
+NX_Q6PD62	RNA polymerase-associated protein CTR9 homolog	1173	133502	6.32	0	Nucleoplasm;Nucleus speckle	NA	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity).	NA	NA	Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins	PE1	11
+NX_Q6PD74	Alpha- and gamma-adaptin-binding protein p34	315	34594	4.5	0	Cytoplasm;Cytosol;Nucleus speckle	Keratoderma, palmoplantar, punctate 1A	May be involved in endocytic recycling of growth factor receptors such as EGFR.	NA	NA	NA	PE1	15
+NX_Q6PDA7	Sperm-associated antigen 11A	123	13842	10.54	0	Secreted	NA	May have antimicrobial activity. May also play a role sperm maturation, storage, and protection.	NA	Belongs to the SPAG11 family.	NA	PE1	8
+NX_Q6PDB4	Zinc finger protein 880	577	66762	9.45	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_Q6PEV8	Protein FAM199X	388	42801	4.95	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the FAM199 family.	NA	PE1	X
+NX_Q6PEW0	Inactive serine protease 54	395	43832	6.22	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family. Plasma kallikrein subfamily.	NA	PE1	16
+NX_Q6PEW1	Zinc finger CCHC domain-containing protein 12	402	45369	5.87	0	Nucleus	NA	Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).	NA	Belongs to the ZCCHC12 family.	NA	PE1	X
+NX_Q6PEX3	Keratin-associated protein 26-1	210	22554	8.03	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the PMG family.	Keratinization	PE1	21
+NX_Q6PEX7	Testis-expressed protein 38	206	23280	5.84	1	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q6PEY0	Gap junction beta-7 protein	223	25860	8.91	4	Gap junction;Cell membrane	NA	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Beta-type (group I) subfamily.	Gap junction assembly	PE2	6
+NX_Q6PEY1	Transmembrane protein 88	159	17251	10.11	2	Cell membrane	NA	Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.	NA	Belongs to the TMEM88 family.	NA	PE1	17
+NX_Q6PEY2	Tubulin alpha-3E chain	450	49859	5.01	0	Cytoskeleton	NA	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).	Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.;Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Nitration of Tyr-450 is irreversible and interferes with normal dynein intracellular distribution.;Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Tubulin alpha-1B chain: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules (PubMed:26972003). In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).;Detyrosinated tubulin alpha-1C chain: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;MHC class II antigen presentation;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	2
+NX_Q6PEZ8	Podocan-like protein 1	512	56539	9.91	0	Extracellular matrix	NA	NA	N-glycosylated.	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily.	NA	PE1	19
+NX_Q6PF04	Zinc finger protein 613	617	70143	9.17	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6PF05	Tetratricopeptide repeat protein 23-like	361	40837	6.81	0	Spindle;Centrosome;Midbody	NA	NA	NA	NA	NA	PE1	5
+NX_Q6PF06	tRNA methyltransferase 10 homolog B	316	36124	7.05	0	Nucleoplasm;Cell membrane	NA	S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).	NA	Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.	NA	PE1	9
+NX_Q6PF15	Kelch-like protein 35	583	62892	8.08	0	Nucleoplasm;Centrosome;Nucleolus	NA	NA	NA	NA	NA	PE1	11
+NX_Q6PF18	MORN repeat-containing protein 3	240	27585	8.63	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	12
+NX_Q6PFW1	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1	1433	159521	5.26	0	Cytosol;Cell membrane	NA	Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.	NA	Belongs to the histidine acid phosphatase family. VIP1 subfamily.	Synthesis of pyrophosphates in the cytosol	PE1	15
+NX_Q6PG37	Zinc finger protein 790	636	74571	8.81	0	Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6PGN9	Proline/serine-rich coiled-coil protein 1	363	38796	11.21	0	Cytoplasm;Nucleoplasm;Spindle pole;Cytosol;Spindle	NA	Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.	Phosphorylated during mitosis.	Belongs to the PSRC1 family.	NA	PE1	1
+NX_Q6PGP7	Tetratricopeptide repeat protein 37	1564	175486	7.47	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Trichohepatoenteric syndrome 1	Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).	NA	NA	RNA degradation;mRNA decay by 3' to 5' exoribonuclease	PE1	5
+NX_Q6PGQ1	Aspartate-rich protein 1	229	25064	3.88	0	Nucleoplasm;Nucleolus;Cell membrane	NA	NA	NA	NA	NA	PE1	22
+NX_Q6PGQ7	Protein aurora borealis	559	61203	4.8	0	Nucleoplasm;Cytosol;Nucleolus	NA	Required for the activation of AURKA at the onset of mitosis.	Phosphorylated by AURKA.;BORA is phosphorylated by AURKA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the BORA family.	Regulation of PLK1 Activity at G2/M Transition	PE1	13
+NX_Q6PH81	UPF0547 protein C16orf87	154	17799	10.09	0	Nucleoplasm	NA	NA	NA	Belongs to the UPF0547 family.	NA	PE1	16
+NX_Q6PH85	DCN1-like protein 2	259	30179	5.7	0	Cytosol;Cell membrane	NA	Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.	NA	NA	Neddylation	PE1	13
+NX_Q6PHR2	Serine/threonine-protein kinase ULK3	472	53444	6.91	0	Cytoplasm	NA	Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.	Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	Regulation of autophagy;mTOR signaling pathway;Hedgehog 'on' state	PE1	15
+NX_Q6PHW0	Iodotyrosine deiodinase 1	289	33360	7.16	1	Cytoplasmic vesicle membrane;Cell membrane	Thyroid dyshormonogenesis 4	Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:25395621, PubMed:18434651). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways (PubMed:18434651). Acts more efficiently on monoiodotyrosine than on diiodotyrosine (PubMed:15289438).	NA	Belongs to the nitroreductase family.	Thyroxine biosynthesis	PE1	6
+NX_Q6PI25	Protein cornichon homolog 2	160	18931	6.87	3	Dendritic spine;Endoplasmic reticulum membrane;Postsynaptic cell membrane;Postsynaptic density;Dendrite	NA	Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.	NA	Belongs to the cornichon family.	COPII-mediated vesicle transport;Cargo concentration in the ER	PE1	11
+NX_Q6PI26	Protein SHQ1 homolog	577	65125	4.7	0	Nucleoplasm;Cytosol	NA	Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.	NA	Belongs to the SHQ1 family.	NA	PE1	3
+NX_Q6PI47	BTB/POZ domain-containing protein KCTD18	426	46739	9.23	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	2
+NX_Q6PI48	Aspartate--tRNA ligase, mitochondrial	645	73563	8.19	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation	NA	NA	Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	1
+NX_Q6PI73	Leukocyte immunoglobulin-like receptor subfamily A member 6	481	52399	7.67	1	Membrane	NA	May act as receptor for class I MHC antigens.	NA	NA	Osteoclast differentiation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q6PI77	Protein BHLHb9	547	60291	7.51	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	May play a role in the control of cellular aging and survival.	NA	Belongs to the GPRASP family.	NA	PE1	X
+NX_Q6PI78	Transmembrane protein 65	240	25498	8.9	3	Nucleoplasm;Mitochondrion inner membrane;Cell membrane	NA	May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance (PubMed:28295037).	NA	NA	NA	PE1	8
+NX_Q6PI97	UPF0722 protein C11orf88	169	19340	8.9	0	NA	NA	NA	NA	Belongs to the UPF0722 family.	NA	PE1	11
+NX_Q6PI98	INO80 complex subunit C	192	20643	10.03	0	Nucleus;Nucleolus	NA	Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	NA	NA	DNA Damage Recognition in GG-NER;UCH proteinases	PE1	18
+NX_Q6PID6	Tetratricopeptide repeat protein 33	262	29411	5.32	0	Golgi apparatus;Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	5
+NX_Q6PID8	Kelch domain-containing protein 10	442	49098	9.47	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.	NA	NA	NA	PE1	7
+NX_Q6PIF2	Synaptonemal complex central element protein 2	218	24690	5.57	0	Nucleoplasm;Nucleus	NA	Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).	NA	Belongs to the SYCE family.	Meiotic synapsis	PE1	19
+NX_Q6PIF6	Unconventional myosin-VIIb	2116	241599	8.82	0	Microvillus;Cytoskeleton	NA	Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	2
+NX_Q6PII3	Coiled-coil domain-containing protein 174	467	53958	6.04	0	Nucleoplasm;Cytoplasm;Nucleolus;Nucleus	Hypotonia, infantile, with psychomotor retardation	Probably involved in neuronal development.	NA	NA	NA	PE1	3
+NX_Q6PII5	Hydroxyacylglutathione hydrolase-like protein	290	31557	8.57	0	NA	NA	Hydrolase acting on ester bonds.	NA	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.	Pyruvate metabolism	PE1	16
+NX_Q6PIJ6	F-box only protein 38	1188	133944	5.92	0	Cell membrane;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Neuronopathy, distal hereditary motor, 2D	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity).	NA	NA	Protein modification; protein ubiquitination.	PE1	5
+NX_Q6PIL6	Kv channel-interacting protein 4	250	28729	5.12	0	Endoplasmic reticulum;Cytoplasm;Cell membrane	NA	Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435).;Does not increase KCND2 expression at the cell membrane (PubMed:18957440).;Retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.	NA	Belongs to the recoverin family.	Phase 1 - inactivation of fast Na+ channels	PE1	4
+NX_Q6PIS1	Solute carrier family 23 member 3	610	64531	7.24	12	Membrane;Nucleoplasm;Cell junction	NA	NA	NA	Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.	NA	PE2	2
+NX_Q6PIU1	Potassium voltage-gated channel subfamily V member 1	500	56304	5.75	6	Cell membrane	NA	Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.	NA	Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.	Voltage gated Potassium channels	PE1	8
+NX_Q6PIU2	Neutral cholesterol ester hydrolase 1	408	45808	6.76	1	Membrane;Endoplasmic reticulum;Microsome	NA	Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.	N-glycosylated.	Belongs to the 'GDXG' lipolytic enzyme family.	Bile secretion;LDL clearance	PE1	3
+NX_Q6PIV2	Forkhead box protein R1	292	33310	9.3	0	Nucleus	NA	NA	NA	NA	NA	PE1	11
+NX_Q6PIV7	Solute carrier family 25 member 34	304	32224	9.28	6	Mitochondrion inner membrane;Mitochondrion	NA	NA	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE2	1
+NX_Q6PIW4	Fidgetin-like protein 1	674	74077	8.07	0	Cytoplasm;Perinuclear region;Nucleus	NA	Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity).	NA	Belongs to the AAA ATPase family.	NA	PE1	7
+NX_Q6PIY5	Armadillo-like helical domain containing protein 1	440	48855	5.56	0	Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q6PIY7	Poly(A) RNA polymerase GLD2	484	56028	9.45	0	Cytoplasm;Cytosol;Nucleus	NA	Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856).	NA	Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.	NA	PE1	5
+NX_Q6PIZ9	T-cell receptor-associated transmembrane adapter 1	186	21211	5.23	1	Cell membrane	NA	Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.	Phosphorylated on tyrosines by LCK or FYN upon TCR activation.	NA	Downstream TCR signaling;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	3
+NX_Q6PJ21	SPRY domain-containing SOCS box protein 3	355	39376	8.74	0	Mitochondrion	NA	May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the SPSB family.	Protein modification; protein ubiquitination.;Neddylation	PE1	16
+NX_Q6PJ61	F-box only protein 46	603	64631	7.19	0	Nucleoplasm;Cytosol;Cytoplasmic vesicle	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	NA	PE1	19
+NX_Q6PJ69	Tripartite motif-containing protein 65	517	57353	6.26	0	Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE1	17
+NX_Q6PJE2	POM121 and ZP3 fusion protein	187	20620	6.81	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_Q6PJF5	Inactive rhomboid protein 2	856	96686	9.1	7	Endoplasmic reticulum membrane;Cell membrane	Tylosis with esophageal cancer	Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.	NA	Belongs to the peptidase S54 family.	NA	PE1	17
+NX_Q6PJG2	ELM2 and SANT domain-containing protein 1	1045	114989	9.26	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	14
+NX_Q6PJG6	BRCA1-associated ATM activator 1	821	88119	5.11	0	Cytoplasm;Nucleoplasm;Nucleus	Rigidity and multifocal seizure syndrome, lethal neonatal;Neurodevelopmental disorder with cerebellar atrophy and with or without seizures	Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994).	Ubiquitinated by NEDD4, NEDD4L and ITCH; mono- and polyubiquitinated forms are detected.	NA	NA	PE1	7
+NX_Q6PJG9	Leucine-rich repeat and fibronectin type-III domain-containing protein 4	635	66860	6.44	1	Membrane	NA	Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity).	Glycosylated.	Belongs to the LRFN family.	Synaptic adhesion-like molecules	PE1	11
+NX_Q6PJI9	GATOR complex protein WDR59	974	109793	8.2	0	Cytosol;Lysosome membrane	NA	As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).	NA	Belongs to the WD repeat WDR59 family.	NA	PE1	16
+NX_Q6PJP8	DNA cross-link repair 1A protein	1040	116400	8.24	0	Nucleoplasm;Nucleus;Nucleolus	NA	May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.	NA	Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.	Fanconi Anemia Pathway	PE1	10
+NX_Q6PJQ5	Forkhead box protein R2	311	35924	4.92	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	X
+NX_Q6PJT7	Zinc finger CCCH domain-containing protein 14	736	82876	6.99	0	Cytoplasm;Nucleus speckle;Nucleolus	Mental retardation, autosomal recessive 56	Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.	NA	Belongs to the ZC3H14 family.	NA	PE1	14
+NX_Q6PJW8	Consortin	725	79597	4.4	1	Cytoplasmic vesicle;trans-Golgi network membrane;Secretory vesicle;Cell membrane	NA	Required for targeting of connexins to the plasma membrane.	NA	Belongs to the CNST family.	NA	PE1	1
+NX_Q6PK04	Coiled-coil domain-containing protein 137	289	33231	10.94	0	Nucleolus;Chromosome	NA	NA	NA	NA	NA	PE1	17
+NX_Q6PK18	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3	319	35646	8.3	1	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the OGFOD3 family.	NA	PE1	17
+NX_Q6PK57	Putative GED domain-containing protein DNM1P34	102	11596	4.82	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_Q6PK81	Zinc finger protein 773	442	50502	9.18	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6PKC3	Thioredoxin domain-containing protein 11	985	110529	6.11	1	Cytosol;Endoplasmic reticulum membrane;Cell membrane	NA	May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.	NA	Belongs to the protein disulfide isomerase family.	NA	PE1	16
+NX_Q6PKG0	La-related protein 1	1096	123510	8.91	0	Cytoplasm;Endoplasmic reticulum;Nucleoplasm;Cytosol;Cytoplasmic granule	NA	(Microbial infection) Positively regulates the replication of dengue virus (DENV).;RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543).	Phosphorylated on multiple Ser and Thr residues in response to active mTORC1. Phosphorylation is important for interaction with RPTOR and the mTORC1 complex. Phosphorylation promotes dissociation from the 5'UTR of mRNA molecules with a 5'TOP motif.	Belongs to the LARP family.	NA	PE1	5
+NX_Q6PKH6	Dehydrogenase/reductase SDR family member 4-like 2	230	24586	10.13	0	Secreted	NA	Probable oxidoreductase.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	NA	PE1	14
+NX_Q6PKX4	Docking protein 6	331	38318	8.72	0	Cytosol;Focal adhesion	NA	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.	On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.	Belongs to the DOK family. Type B subfamily.	RET signaling	PE1	18
+NX_Q6PL18	ATPase family AAA domain-containing protein 2	1390	158554	5.94	0	Nucleoplasm;Nucleus	NA	May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.	NA	Belongs to the AAA ATPase family.	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	PE1	8
+NX_Q6PL24	Protein TMED8	325	35740	4.61	0	NA	NA	NA	NA	NA	NA	PE1	14
+NX_Q6PL45	BRICHOS domain-containing protein 5	260	28486	6.98	2	Membrane;Nucleoplasm;Cytoskeleton	NA	NA	NA	NA	NA	PE1	16
+NX_Q6PML9	Zinc transporter 9	568	63515	8.6	5	Cytoplasm;Membrane;Endoplasmic reticulum;Cytoplasmic vesicle;Nucleus	Birk-Landau-Perez syndrome	Acts as a zinc transporter involved in intracellular zinc homeostasis (PubMed:28334855). Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (By similarity).	NA	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.	NA	PE1	4
+NX_Q6PP77	XK-related protein 2	449	52052	8.46	10	Cell membrane	NA	NA	NA	Belongs to the XK family.	NA	PE2	X
+NX_Q6PRD1	Probable G-protein coupled receptor 179	2367	257363	5.54	7	Cell membrane	Night blindness, congenital stationary, 1E	Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells.	NA	Belongs to the G-protein coupled receptor 3 family.	NA	PE1	17
+NX_Q6PRD7	Cementoblastoma-derived protein 1	247	25959	9.73	0	Nucleoplasm;Cytoplasm;Nucleus	NA	May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum (PubMed:21929512, PubMed:17509525, PubMed:21465469). Binds hydroxyapatite and may promote the biomineralization of the cementum (PubMed:19393626). Also promotes cell proliferation (PubMed:17509525, PubMed:21929512, PubMed:26011628).	N-glycosylated.;Phosphorylated.	NA	NA	PE1	16
+NX_Q6PUV4	Complexin-2	134	15394	5.06	0	Presynapse;Perikaryon;Nucleus;Cytosol	NA	Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).	NA	Belongs to the complexin/synaphin family.	Synaptic vesicle cycle	PE1	5
+NX_Q6PXP3	Solute carrier family 2, facilitated glucose transporter member 7	512	55728	8.68	12	Cell membrane	NA	Probable sugar transporter (PubMed:28083649). Its physiological substrate is subject to discussion (PubMed:16186102, PubMed:28083649). Does not transport galactose, 2-deoxy-d-glucose and xylose (PubMed:15033637).	NA	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Cellular hexose transport	PE1	1
+NX_Q6Q0C0	E3 ubiquitin-protein ligase TRAF7	670	74609	6.77	0	Cytoplasmic vesicle;Cell membrane	Cardiac, facial, and digital anomalies with developmental delay	E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Induces apoptosis when overexpressed (PubMed:15001576). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.	Phosphorylated by MAP3K3.;Ubiquitinates itself upon phosphorylation.	Belongs to the WD repeat TRAF7 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	16
+NX_Q6Q0C1	Solute carrier family 25 member 47	308	33435	9.39	6	Mitochondrion inner membrane	NA	Uncoupling protein which may catalyze the physiological 'proton leak' in liver. Overexpression induces the dissipation of mitochondrial membrane potential.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE2	14
+NX_Q6Q4G3	Aminopeptidase Q	990	113283	5.42	1	Membrane	NA	Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.	N-glycosylated.	Belongs to the peptidase M1 family.	NA	PE1	5
+NX_Q6Q6R5	Cysteine-rich protein 3	217	24088	8.98	0	Cytoplasm;Nucleus speckle	NA	NA	NA	NA	NA	PE1	6
+NX_Q6Q759	Sperm-associated antigen 17	2223	251742	5.88	0	Cytoplasm;Flagellum axoneme	NA	Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts.	NA	NA	NA	PE1	1
+NX_Q6Q788	Apolipoprotein A-V	366	41213	5.98	0	trans-Golgi network;Early endosome;Secreted;Late endosome	Hypertriglyceridemia, familial;Hyperlipoproteinemia 5	Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed:17326667).	Phosphorylated by FAM20C in the extracellular medium.	Belongs to the apolipoprotein A1/A4/E family.	PPAR signaling pathway;PPARA activates gene expression;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Assembly of active LPL and LIPC lipase complexes;Chylomicron remodeling	PE1	11
+NX_Q6Q795	Putative viral protein-binding protein C1	121	13358	8.84	0	NA	NA	NA	NA	NA	NA	PE5	3
+NX_Q6Q8B3	Cell surface glycoprotein CD200 receptor 2	271	29920	9.31	1	Membrane	NA	May be a receptor for the CD200/OX2 cell surface glycoprotein.	NA	Belongs to the CD200R family.	NA	PE2	3
+NX_Q6QAJ8	Transmembrane protein 220	160	17754	6.95	5	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE2	17
+NX_Q6QEF8	Coronin-6	472	52762	5.63	0	Golgi apparatus	NA	NA	NA	NA	NA	PE1	17
+NX_Q6QHC5	Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2	323	37197	9.38	3	Nucleoplasm;Endoplasmic reticulum membrane;Nucleolus	NA	Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.	NA	Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.	Membrane lipid metabolism; sphingolipid biosynthesis.;Sphingolipid metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis	PE1	14
+NX_Q6QHF9	Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	649	70290	5.34	0	Peroxisome;Nucleoplasm;Cytoplasm;Centrosome	NA	Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380).	NA	Belongs to the flavin monoamine oxidase family.	Amine and polyamine metabolism; spermine metabolism.;Peroxisome;PAOs oxidise polyamines to amines;Interconversion of polyamines;Peroxisomal protein import	PE1	10
+NX_Q6QHK4	Factor in the germline alpha	219	24123	7.76	0	Nucleus	Premature ovarian failure 6	Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.	NA	NA	NA	PE1	2
+NX_Q6QN14	Ubiquitin carboxyl-terminal hydrolase 17-like protein 6	398	44690	6.86	0	Cytoplasm;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, cell migration, and the cellular response to viral infection. Seems to be non-functional in the regulation of apoptosis.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	NA	PE1	4
+NX_Q6QNK2	Adhesion G-protein coupled receptor D1	874	96530	8.02	7	Nucleoplasm;Cytosol;Cell membrane	NA	Orphan receptor. Signals via G(s)-alpha family of G-proteins (PubMed:22025619, PubMed:22575658). Has protumorigenic function especially in glioblastoma (PubMed:27775701).	NA	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	12
+NX_Q6QNY0	Biogenesis of lysosome-related organelles complex 1 subunit 3	202	21256	5.08	0	Golgi apparatus;Cytoplasm	Hermansky-Pudlak syndrome 8	Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.	NA	Belongs to the BLOC1S3 family.	Golgi Associated Vesicle Biogenesis	PE1	19
+NX_Q6QNY1	Biogenesis of lysosome-related organelles complex 1 subunit 2	142	15961	4.78	0	Lysosome membrane;Centrosome	NA	Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421).	NA	Belongs to the BLOC1S2 family.	NA	PE1	10
+NX_Q6R2W3	SCAN domain-containing protein 3	1325	151666	6.29	0	Golgi apparatus;Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	6
+NX_Q6R327	Rapamycin-insensitive companion of mTOR	1708	192218	7.22	0	Mitochondrion	NA	Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. MTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. MTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. MTORC2 promotes the serum-induced formation of stress-fibers or F-actin. MTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. MTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. MTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.	Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.	Belongs to the RICTOR family.	mTOR signaling pathway;PIP3 activates AKT signaling;VEGFR2 mediated vascular permeability;CD28 dependent PI3K/Akt signaling;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation	PE1	5
+NX_Q6R6M4	Ubiquitin carboxyl-terminal hydrolase 17	530	59619	8.5	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE1	8
+NX_Q6RFH5	WD repeat-containing protein 74	385	42441	8.64	0	Nucleoplasm;Nucleus;Nucleolus	NA	Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651). Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693). Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity).	NA	NA	NA	PE1	11
+NX_Q6RFH8	Double homeobox protein 4C	374	39442	11.11	0	Nucleus	NA	May be involved in transcriptional regulation (By similarity). Down-regulates MYOD1 expression and may up-regulate MYF5 expression. May regulate microRNA (miRNA) transcription, upregulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206. Impairs the differentiation of myoblasts and may be involved in muscle regeneration.	NA	NA	NA	PE1	4
+NX_Q6RI45	Bromodomain and WD repeat-containing protein 3	1802	203598	8.02	0	Nucleoplasm;Cytosol	Mental retardation, X-linked 93	Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.	NA	NA	NA	PE1	X
+NX_Q6RSH7	von Hippel-Lindau-like protein	139	15781	6.41	0	NA	NA	Functions as a dominant-negative VHL to serve as a protector of HIFalpha.	NA	Belongs to the VHL family.	NA	PE1	1
+NX_Q6RUI8	Uncharacterized protein C19orf48	117	13085	8.49	0	Cell membrane	NA	NA	NA	NA	NA	PE2	19
+NX_Q6RVD6	Spermatogenesis-associated protein 8	105	11727	10.09	0	NA	NA	NA	NA	NA	NA	PE1	15
+NX_Q6RW13	Type-1 angiotensin II receptor-associated protein	159	17419	5.71	3	Cytoplasmic vesicle membrane;Golgi apparatus membrane;Endoplasmic reticulum membrane;Cytoplasmic vesicle	NA	Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.	NA	NA	Signaling by BRAF and RAF fusions	PE1	1
+NX_Q6S545	POTE ankyrin domain family member H	545	60965	7	0	NA	NA	NA	NA	Belongs to the POTE family.	NA	PE1	22
+NX_Q6S5H5	POTE ankyrin domain family member G	508	57096	6.66	0	NA	NA	NA	NA	Belongs to the POTE family.	NA	PE2	14
+NX_Q6S5L8	SHC-transforming protein 4	630	68785	8.03	0	Cytosol;Postsynaptic cell membrane	NA	Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.	Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.	NA	ErbB signaling pathway;Chemokine signaling pathway;Focal adhesion;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Insulin signaling pathway;Bacterial invasion of epithelial cells;Glioma;Chronic myeloid leukemia	PE1	15
+NX_Q6S8J3	POTE ankyrin domain family member E	1075	121363	5.83	0	NA	NA	NA	NA	In the N-terminal section; belongs to the POTE family.;In the C-terminal section; belongs to the actin family.	NA	PE1	2
+NX_Q6S8J7	POTE ankyrin domain family member A	498	56166	6.01	0	NA	NA	NA	NA	Belongs to the POTE family.	NA	PE2	8
+NX_Q6S9Z5	Zinc finger protein 474	364	40315	9.59	0	NA	NA	NA	NA	NA	NA	PE1	5
+NX_Q6SA08	Testis-specific serine/threonine-protein kinase 4	328	37454	8.78	0	Cell junction;Acrosome;Flagellum	NA	Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity).	Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.;Activated by autophosphorylation on Thr-197. ODF2 potentiates the autophosphorylation activity of TSSK4 at Thr-197.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	14
+NX_Q6SJ93	Protein FAM111B	734	84674	8.83	0	Nucleoplasm;Cytosol	Poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis	NA	NA	Belongs to the FAM111 family.	NA	PE1	11
+NX_Q6SJ96	TATA box-binding protein-like protein 2	375	41524	6.05	0	Cytoplasm;Nucleus	NA	Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).	NA	Belongs to the TBP family.	Basal transcription factors;Huntington's disease;HTLV-I infection;Herpes simplex infection	PE1	14
+NX_Q6SPF0	Atherin	538	56052	7.13	0	Cytoplasm;Cytosol;Mitochondrion;Secreted	NA	May play a role in atherogenesis by immobilizing LDL in the atherial wall.	NA	NA	NA	PE1	19
+NX_Q6STE5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3	483	55016	9.38	0	Nucleoplasm;Nucleus	NA	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).	NA	Belongs to the SMARCD family.	RMTs methylate histone arginines;PPARA activates gene expression;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	7
+NX_Q6SZW1	Sterile alpha and TIR motif-containing protein 1	724	79388	6.14	0	Cytoplasm;Mitochondrion;Synapse;Cytoplasmic vesicle;Axon;Dendrite	NA	Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.	NA	NA	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;MyD88-independent TLR4 cascade;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Toll Like Receptor 3 (TLR3) Cascade	PE1	17
+NX_Q6T310	Ras-like protein family member 11A	242	27006	9.05	0	Nucleus;Nucleolus	NA	Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).	NA	Belongs to the small GTPase superfamily. Ras family.	NA	PE1	13
+NX_Q6T311	ADP-ribosylation factor-like protein 9	187	20755	6.04	0	Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	4
+NX_Q6T423	Solute carrier family 22 member 25	547	61008	7.53	12	Membrane	NA	NA	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	NA	PE2	11
+NX_Q6T4P5	Phospholipid phosphatase-related protein type 3	718	76037	5.66	6	Membrane;Golgi apparatus;Cytosol;Nucleoplasm	NA	NA	NA	Belongs to the PA-phosphatase related phosphoesterase family.	Lysosphingolipid and LPA receptors	PE1	19
+NX_Q6T4R5	Nance-Horan syndrome protein	1651	179135	6.4	0	Cytoplasm;Cell junction;Focal adhesion;Lamellipodium;Tight junction;Apical cell membrane	Nance-Horan syndrome;Cataract 40	May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development.	NA	Belongs to the NHS family.	NA	PE1	X
+NX_Q6TCH4	Membrane progestin receptor delta	344	37989	8.22	7	Nucleoplasm;Nucleolus;Cell membrane	NA	Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870).	NA	Belongs to the ADIPOR family.	NA	PE1	1
+NX_Q6TCH7	Progestin and adipoQ receptor family member 3	311	36217	8.84	7	Golgi apparatus membrane	NA	Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.	NA	Belongs to the ADIPOR family.	Negative regulation of MAPK pathway	PE1	4
+NX_Q6TDP4	Kelch-like protein 17	642	69874	7.64	0	Nucleoplasm;Nucleus;Postsynaptic density;Synapse	NA	Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).	NA	NA	Protein modification; protein ubiquitination.	PE1	1
+NX_Q6TDU7	Protein CASC1	716	83160	5.22	0	NA	NA	NA	NA	Belongs to the CASC1 family.	NA	PE1	12
+NX_Q6TFL3	Coiled-coil domain-containing protein 171	1326	152810	6.37	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	9
+NX_Q6TFL4	Kelch-like protein 24	600	68361	5.98	0	Cytoplasm;Desmosome;Perikaryon;Adherens junction;Axon	Epidermolysis bullosa simplex, generalized, with scarring and hair loss	Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity).	Autoubiquitinated. Autoubiquitination leads to proteasomal degradation and is necessary to control KLHL24 levels.	NA	NA	PE1	3
+NX_Q6TGC4	Protein-arginine deiminase type-6	694	77727	5.13	0	Cytoplasm;Nucleus	Preimplantation embryonic lethality 2	Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678).	Phosphorylation at Ser-10, possibly by RSK-type kinases, and Ser-446 creates binding sites for 14-3-3 proteins.	Belongs to the protein arginine deiminase family.	Chromatin modifying enzymes	PE1	1
+NX_Q6U736	Opsin-5	354	39727	9.11	7	Membrane	NA	NA	It is uncertain whether Cys-315 or Cys-316 is palmitoylated.	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	G alpha (i) signalling events;Opsins	PE1	6
+NX_Q6U7Q0	Zinc finger protein 322	402	46941	8.98	0	Cytoplasm;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_Q6U841	Sodium-driven chloride bicarbonate exchanger	1118	125946	6.05	12	Basolateral cell membrane;Perikaryon;Postsynapse;Presynapse;Apical cell membrane;Axon;Dendrite	NA	Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:10993873, PubMed:18319254). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (PubMed:18319254). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity).	NA	Belongs to the anion exchanger (TC 2.A.31) family.	Bicarbonate transporters	PE1	2
+NX_Q6U949	Putative insulin-like growth factor 2 antisense gene protein	168	18035	12.13	0	NA	NA	NA	NA	NA	NA	PE2	11
+NX_Q6UB28	Methionine aminopeptidase 1D, mitochondrial	335	37088	6.35	0	Cytoplasmic vesicle;Mitochondrion	NA	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.	NA	Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	NA	PE1	2
+NX_Q6UB35	Monofunctional C1-tetrahydrofolate synthase, mitochondrial	978	105790	8.32	0	Mitochondrion	NA	May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2.	NA	In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.;In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.	One-carbon metabolism; tetrahydrofolate interconversion.;One carbon pool by folate;Metabolic pathways;Metabolism of folate and pterines	PE1	6
+NX_Q6UB98	Ankyrin repeat domain-containing protein 12	2062	235652	6.57	0	Nucleoplasm;Cytosol;Nucleus	NA	May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.	NA	NA	NA	PE1	18
+NX_Q6UB99	Ankyrin repeat domain-containing protein 11	2663	297913	6.7	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	KBG syndrome	Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity).	Subject to proteasomal degradation which is probably essential to regulate its activity.	NA	NA	PE1	16
+NX_Q6UDR6	Kunitz-type protease inhibitor 4	99	11421	9.4	0	Secreted	NA	NA	NA	NA	NA	PE1	20
+NX_Q6UE05	Transmembrane protein 270	265	29433	7.67	3	Membrane;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	7
+NX_Q6ULP2	Aftiphilin	936	102113	4.4	0	Golgi apparatus;Cytosol;Cytoplasm;Cytoplasmic vesicle	NA	May play a role in membrane trafficking.	NA	NA	NA	PE1	2
+NX_Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	594	66526	5.42	0	Nucleoplasm;Nucleus	NA	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.	NA	Belongs to the FIP1 family.	mRNA surveillance pathway;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	4
+NX_Q6UQ28	Placenta-expressed transcript 1 protein	207	23385	5.01	0	Apical cell membrane	NA	Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).	N-glycosylated.;GPI-anchored.	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE2	11
+NX_Q6URK8	Testis, prostate and placenta-expressed protein	271	30717	9.09	0	Secreted	NA	NA	NA	NA	NA	PE1	16
+NX_Q6UUV7	CREB-regulated transcription coactivator 3	619	66959	6.35	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).	Phosphorylation/dephosphorylation states of Ser-273 are required for regulating transduction of CREB activity (By similarity). CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site (By similarity). May be phosphorylated at Ser-391 by MAPK3/ERK1 and/or MAPK1/ERK2 or by some cyclin-dependent kinases such as CDK1,CDK2 or CDK5 (PubMed:30611118). Following adenylyl cyclase activation, dephosphorylated at Ser-162 and Ser-273 resulting in its dissociation from 14-3-3 proteins probably promoting CRTC3 translocation into the nucleus (PubMed:30611118).	Belongs to the TORC family.	HTLV-I infection;Circadian Clock;Transcriptional activation of mitochondrial biogenesis	PE1	15
+NX_Q6UUV9	CREB-regulated transcription coactivator 1	634	67300	5.65	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	(Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).;Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.	Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity).	Belongs to the TORC family.	HTLV-I infection;Circadian Clock;Transcriptional activation of mitochondrial biogenesis	PE1	19
+NX_Q6UVJ0	Spindle assembly abnormal protein 6 homolog	657	74397	7.26	0	Cytosol;Centriolar satellite;Centrosome;Centriole	Microcephaly 14, primary, autosomal recessive	Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124).	Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during S phase, leading to its degradation and preventing centriole reduplication.	NA	NA	PE1	1
+NX_Q6UVK1	Chondroitin sulfate proteoglycan 4	2322	250537	5.27	1	Cell membrane;Lamellipodium membrane;Cell surface;Nucleoplasm;Apical cell membrane	NA	Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.	Phosphorylation by PRKCA regulates its subcellular location and function in cell motility.;O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4.	NA	Chondroitin sulfate biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Dermatan sulfate biosynthesis;CS/DS degradation;Defective CHST3 causes SEDCJD;Defective CHST14 causes EDS, musculocontractural type;Defective CHSY1 causes TPBS;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	15
+NX_Q6UVM3	Potassium channel subfamily T member 2	1135	130501	6.97	6	Cytoplasmic vesicle;Cell membrane	Epileptic encephalopathy, early infantile, 57	Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600). Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497).	Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity.	Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily.	NA	PE1	1
+NX_Q6UVW9	C-type lectin domain family 2 member A	174	19972	8.75	1	Cell membrane	NA	Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.	N-glycosylated.	NA	NA	PE1	12
+NX_Q6UVY6	DBH-like monooxygenase protein 1	613	69652	5.97	1	Cytosol;Endoplasmic reticulum membrane	NA	NA	N-glycosylated.	Belongs to the copper type II ascorbate-dependent monooxygenase family.	NA	PE1	6
+NX_Q6UW01	Cerebellin-3	205	21521	6.58	0	Secreted;Endoplasmic reticulum;Nucleoplasm;Synapse;cis-Golgi network	NA	May be involved in synaptic functions in the CNS.	NA	NA	NA	PE1	14
+NX_Q6UW02	Cytochrome P450 20A1	462	52432	5.84	1	Cell membrane;Cell junction;Membrane;Nucleoplasm;Cytoskeleton	NA	NA	NA	Belongs to the cytochrome P450 family.	NA	PE1	2
+NX_Q6UW10	Surfactant-associated protein 2	78	8396	7.01	0	Golgi apparatus;Secreted;Secretory vesicle	NA	Putative surfactant protein.	N-glycosylated.	NA	NA	PE1	6
+NX_Q6UW15	Regenerating islet-derived protein 3-gamma	175	19330	6.7	0	Cytoplasm;Secreted	NA	Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.	Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.	NA	Antimicrobial peptides	PE1	2
+NX_Q6UW32	Insulin growth factor-like family member 1	110	12363	8.22	0	Secreted	NA	Probable ligand of the IGFLR1 cell membrane receptor.	NA	Belongs to the IGFL family.	NA	PE1	19
+NX_Q6UW49	Sperm equatorial segment protein 1	350	38931	5.53	0	Acrosome	NA	Involved in fertilization ability of sperm.	Glycosylated. In testis there are two predominant forms of 77- and 67-kDa and a form of 47-kDa, whereas in epididymal sperm from caput, corpus, and cauda there are two forms of 47- and 43-kDa. Testis forms contain complex carbohydrate residues. Epididymal sperm forms are N-glycosylated. Then undergoes significant glycosylation in the testis and that the majority of these glycoconjugates are removed by the time sperm reach the caput epididymis.	Belongs to the SPESP1 family.	NA	PE1	15
+NX_Q6UW56	All-trans retinoic acid-induced differentiation factor	229	24747	6.95	1	Nucleus envelope;Cell membrane	NA	Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.	NA	NA	NA	PE1	2
+NX_Q6UW60	Proprotein convertase subtilisin/kexin type 4	755	82795	8.67	1	Membrane;Acrosome membrane	NA	Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806). May also participate in folliculogenesis in the ovaries (By similarity).	N-glycosylated.;Synthesized in the endoplasmic reticulum as a zymogen, is matured by autocatalytic cleavage between the prodomain and the catalytic domain.	Belongs to the peptidase S8 family. Furin subfamily.	NA	PE1	19
+NX_Q6UW63	Protein O-glucosyltransferase 2	502	58043	7.59	0	Nucleoplasm;Endoplasmic reticulum lumen	NA	Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1 and NOTCH3 (PubMed:30127001). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001).	N-glycosylated.	Belongs to the KDELC family.	Protein modification; protein glycosylation.	PE1	13
+NX_Q6UW68	Transmembrane protein 205	189	21198	8.91	4	Membrane;Endoplasmic reticulum;Nucleoplasm;Nucleus membrane	NA	In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.	NA	Belongs to the TMEM205 family.	NA	PE1	19
+NX_Q6UW78	Ubiquinol-cytochrome-c reductase complex assembly factor 3	93	10081	9.39	1	Nucleoplasm;Cytosol;Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex III deficiency, nuclear 9	Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.	Probably cleaved by OMA1 under mitochondrial stress conditions.	Belongs to the UQCC3 family.	NA	PE1	11
+NX_Q6UW88	Epigen	154	17091	6.5	1	Secreted;Membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.	NA	NA	RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;EGFR downregulation;Signaling by EGFR;GAB1 signalosome;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;EGFR interacts with phospholipase C-gamma;Inhibition of Signaling by Overexpressed EGFR;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Extra-nuclear estrogen signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	4
+NX_Q6UWB1	Interleukin-27 receptor subunit alpha	636	69474	5.48	1	Membrane;Cytoplasmic vesicle	NA	Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.	NA	Belongs to the type I cytokine receptor family. Type 2 subfamily.	Interleukin-35 Signalling;Interleukin-27 signaling	PE1	19
+NX_Q6UWB4	Serine protease 55	352	38856	7.49	1	Membrane;Cytosol	NA	Probable serine protease.	NA	Belongs to the peptidase S1 family.	NA	PE1	8
+NX_Q6UWD8	Transmembrane protein C16orf54	224	24360	5.97	1	Membrane	NA	NA	O-glycosylated with core 1 or possibly core 8 glycans.	NA	NA	PE1	16
+NX_Q6UWE0	E3 ubiquitin-protein ligase LRSAM1	723	83594	5.7	0	Cytoplasm;Cytosol	Charcot-Marie-Tooth disease 2P	E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098).	Ubiquitination promoted by PHF23 leads to proteasomal degradation.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	9
+NX_Q6UWE3	Colipase-like protein 2	100	10812	8.85	0	Secreted	NA	NA	NA	Belongs to the colipase family.	NA	PE1	6
+NX_Q6UWF3	SLP adapter and CSK-interacting membrane protein	145	16618	5.21	1	Ruffle;Filopodium;Phagosome;Cell membrane	NA	Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity).	Palmitoylated.;Phosphorylated by the Src-family protein tyrosine kinases LYN and SRC (PubMed:21930792). Phosphorylation occurs on tyrosine residues upon MHC-II stimulation (PubMed:21930792). Phosphorylation also occurs on tyrosine residues after activation of CLEC7A/DECTIN1 by particulate beta-glucan (By similarity). Lipopolysaccharide (LPS) induces phosphorylation of Tyr-69, Tyr-107 and Tyr-131 differentially to allow temporal recruitment of effector proteins GRB2, CSK and BLNK (By similarity). Phosphorylation of Tyr-69 is immediately induced by LPS stimulation and allows GRB2 to bind (By similarity). Tyr-107 is phosphorylated 5 minutes after LPS stimulation, which then allows CSK to bind, followed by phosphorylation of Tyr-131 10 minutes after LPS induction, which allows BLNK to bind (By similarity). Phosphorylation at Tyr-107 by LYN occurs after activation of TLR4 by lipopolysaccharide; phosphorylation enhances binding to TLR4 (By similarity).;SCIMP is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	NA	NA	PE1	17
+NX_Q6UWF5	Putative uncharacterized protein UNQ5815/PRO19632	114	12886	6.56	2	Membrane	NA	NA	NA	NA	NA	PE4	6
+NX_Q6UWF7	NXPE family member 4	544	62263	9.03	0	Secreted	NA	NA	NA	Belongs to the NXPE family.	NA	PE1	11
+NX_Q6UWF9	Protein FAM180A	173	19733	8.59	0	Nucleoplasm;Secreted	NA	NA	NA	Belongs to the FAM180 family.	NA	PE1	7
+NX_Q6UWH4	Golgi-associated kinase 1B	519	57552	9.75	1	Golgi apparatus;Nucleoplasm;Nucleolus;Golgi apparatus membrane	NA	NA	NA	Belongs to the GASK family.	NA	PE1	4
+NX_Q6UWH6	Protein TEX261	196	22538	6.56	5	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the SVP26 family.	NA	PE1	2
+NX_Q6UWI2	Prostate androgen-regulated mucin-like protein 1	310	32289	4.59	1	Endosome membrane;Cell membrane;Nucleoplasm;Endosome;Golgi apparatus membrane;Cytoplasmic vesicle;Cytosol	NA	May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.	Highly N-glycosylated and O-glycosylated.	Belongs to the PARM family.	NA	PE1	4
+NX_Q6UWI4	Protein shisa-2 homolog	295	31375	7.89	1	Nucleoplasm;Endoplasmic reticulum membrane;Nucleus;Cytoplasmic vesicle	NA	Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.	NA	Belongs to the shisa family.	NA	PE1	13
+NX_Q6UWJ1	Transmembrane and coiled-coil domain-containing protein 3	677	75598	6.47	10	Membrane;Cytosol	NA	Probable Na(+)/H(+) antiporter.	NA	Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	NA	PE1	13
+NX_Q6UWJ8	CD164 sialomucin-like 2 protein	174	18403	6.63	1	Membrane;Cytosol;Cell membrane	NA	NA	NA	Belongs to the CD164 family.	NA	PE1	1
+NX_Q6UWK7	Protein GPR15L	81	9173	10.54	0	Secreted	NA	Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed:25585381).;Chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403).	NA	NA	NA	PE1	10
+NX_Q6UWL2	Sushi domain-containing protein 1	747	82710	6.02	1	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	9
+NX_Q6UWL6	Kin of IRRE-like protein 2	708	75092	6.48	1	Cytoplasm;Centriolar satellite;Nucleus;Cell membrane	NA	May regulate basal insulin secretion.	The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase.;N-glycosylated.	Belongs to the immunoglobulin superfamily.	Nephrin family interactions	PE1	19
+NX_Q6UWM5	GLIPR1-like protein 1	242	27151	8.57	0	Acrosome;Membrane raft;Cell membrane	NA	Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region.	N-glycosylated. N-glycosylation decreases during the transit in the caput.	Belongs to the CRISP family.	NA	PE1	12
+NX_Q6UWM7	Lactase-like protein	567	65088	8.17	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Cell membrane	NA	Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens.	NA	Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.	NA	PE1	15
+NX_Q6UWM9	UDP-glucuronosyltransferase 2A3	527	60254	8.15	1	Membrane	NA	UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	4
+NX_Q6UWN0	Ly6/PLAUR domain-containing protein 4	246	26763	8.76	0	Cell membrane	NA	NA	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	19
+NX_Q6UWN5	Ly6/PLAUR domain-containing protein 5	251	26936	6.98	0	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	19
+NX_Q6UWN8	Serine protease inhibitor Kazal-type 6	80	8585	8.74	0	Secreted	NA	Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.	NA	NA	Formation of the cornified envelope	PE1	5
+NX_Q6UWP2	Dehydrogenase/reductase SDR family member 11	260	28308	6.17	0	Golgi apparatus;Cytosol;Secreted	NA	Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Steroid biosynthesis; estrogen biosynthesis.	PE1	17
+NX_Q6UWP7	Lysocardiolipin acyltransferase 1	414	48920	8.83	4	Endoplasmic reticulum;Cytosol;Endoplasmic reticulum membrane	NA	Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16620771). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (PubMed:19075029). Required for establishment of the hematopoietic and endothelial lineages (By similarity).	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.;Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PA;Acyl chain remodeling of CL	PE1	2
+NX_Q6UWP8	Suprabasin	590	60541	6.5	0	Cytoplasmic vesicle;Secreted	NA	NA	NA	NA	NA	PE1	19
+NX_Q6UWQ5	Lysozyme-like protein 1	148	16654	8.35	0	Secreted	NA	NA	NA	Belongs to the glycosyl hydrolase 22 family.	NA	PE1	10
+NX_Q6UWQ7	Insulin growth factor-like family member 2	119	13248	7.4	0	Nucleoplasm;Secreted;Cell membrane	NA	Potential ligand of the IGFLR1 cell membrane receptor.	NA	Belongs to the IGFL family.	NA	PE2	19
+NX_Q6UWR7	Ectonucleotide pyrophosphatase/phosphodiesterase family member 6	440	50241	8.07	0	Golgi apparatus;Cell membrane	NA	Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.	NA	Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.	Ether lipid metabolism;Glycerophospholipid catabolism	PE1	4
+NX_Q6UWS5	Protein PET117 homolog, mitochondrial	81	9223	10.1	0	Mitochondrion	NA	NA	NA	Belongs to the PET117 family.	NA	PE1	20
+NX_Q6UWT2	Adropin	76	7927	5.38	0	Secreted	NA	Involved in the regulation of glucose homeostasis and lipid metabolism.	NA	NA	NA	PE2	9
+NX_Q6UWT4	Uncharacterized protein C5orf46	87	9693	4.67	0	Nucleus speckle;Secreted;Mitochondrion	NA	NA	NA	NA	NA	PE1	5
+NX_Q6UWU2	Beta-galactosidase-1-like protein	654	74158	9.01	0	Secreted	NA	Probable glycosyl hydrolase.	NA	Belongs to the glycosyl hydrolase 35 family.	Glycosphingolipid metabolism;Keratan sulfate degradation;HS-GAG degradation	PE1	2
+NX_Q6UWU4	Bombesin receptor-activated protein C6orf89	347	39870	6.36	1	Cytoplasm;Nucleolus;Midbody;Golgi apparatus membrane	NA	Exhibits histone deacetylase (HDAC) enhancer properties (PubMed:23460338). May play a role in cell cycle progression and wound repair of bronchial epithelial cells (PubMed:21857995).	Glycosylated.	NA	NA	PE1	6
+NX_Q6UWV2	Myelin protein zero-like protein 3	235	25989	8.12	1	Membrane;Golgi apparatus	NA	Mediates homophilic cell-cell adhesion.	NA	Belongs to the myelin P0 protein family.	NA	PE1	11
+NX_Q6UWV6	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7	458	51494	6.39	1	Cell membrane	NA	Converts sphingomyelin to ceramide and phosphocholine (PubMed:12885774, PubMed:12671034, PubMed:15205117, PubMed:28292932). Has also phospholipase C activity and can cleave phosphocholine from palmitoyl lyso-phosphatidylcholine (PubMed:12885774). Does not have nucleotide pyrophosphatase activity (PubMed:12885774).	N-glycosylated; required for activity and transport to the plasma membrane.	Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.	Sphingolipid metabolism;Metabolic pathways;Glycosphingolipid metabolism	PE1	17
+NX_Q6UWV7	Protein shisa-like-2A	190	20306	4.94	2	Membrane	NA	NA	NA	Belongs to the shisa family.	NA	PE2	1
+NX_Q6UWW0	Lipocalin-15	184	20454	4.8	0	Secreted	NA	NA	NA	Belongs to the calycin superfamily. Lipocalin family.	Transport of fatty acids	PE1	9
+NX_Q6UWW8	Carboxylesterase 3	571	62282	5.41	0	Endoplasmic reticulum;Endoplasmic reticulum lumen;Nucleus membrane	NA	Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.	N-glycosylated.	Belongs to the type-B carboxylesterase/lipase family.	Phase I - Functionalization of compounds;LDL clearance	PE1	16
+NX_Q6UWW9	Transmembrane protein 207	146	16116	4.95	1	Membrane	NA	NA	NA	NA	NA	PE1	3
+NX_Q6UWX4	HHIP-like protein 2	724	80779	9.21	0	Cytosol;Mitochondrion;Secreted	NA	NA	NA	Belongs to the HHIP family.	NA	PE1	1
+NX_Q6UWY0	Arylsulfatase K	536	61450	9.02	0	Nucleoplasm;Secreted;Cytoplasmic vesicle	NA	NA	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Glycosphingolipid metabolism;The activation of arylsulfatases	PE1	5
+NX_Q6UWY2	Serine protease 57	283	30334	9.56	0	Cytoplasmic granule lumen;Secreted	NA	Serine protease that cleaves preferentially after Arg residues (PubMed:22474388, PubMed:23904161, PubMed:25156428). Can also cleave after citrulline (deimidated arginine) and methylarginine residues (PubMed:25156428).	N-glycosylated.;After cleavage of the signal peptide, the N-terminus is probably further processed by CTSC (PubMed:22474388, PubMed:23904161). Processing by CTSC is probably required for accumulation in cytoplasmic granules; in the absence of CTSC the protein does not accumulate (PubMed:23904161).	Belongs to the peptidase S1 family.	NA	PE1	19
+NX_Q6UWY5	Olfactomedin-like protein 1	402	45951	8.29	0	Secreted	NA	NA	Highly N-glycosylated.	NA	NA	PE1	11
+NX_Q6UWZ7	BRCA1-A complex subunit Abraxas 1	409	46663	6.58	0	Nucleus	Breast cancer	Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.	Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1 (PubMed:17643121, PubMed:17525340, PubMed:17643122). Ionizing radiation promotes rapid phosphorylation at Ser-404 and Ser-406 by ATM; this promotes recruitment of BRCA1 to sites of DNA damage (PubMed:26778126).	Belongs to the FAM175 family. Abraxas subfamily.	G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Metalloprotease DUBs	PE1	4
+NX_Q6UX01	Protein LMBR1L	489	55209	8.39	9	Endoplasmic reticulum membrane;Cell membrane	NA	Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685).	NA	Belongs to the LIMR family.	NA	PE1	12
+NX_Q6UX04	Spliceosome-associated protein CWC27 homolog	472	53847	5.6	0	Nucleoplasm;Nucleus	Retinitis pigmentosa with or without skeletal anomalies	As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).	NA	Belongs to the cyclophilin-type PPIase family.	mRNA Splicing - Major Pathway	PE1	5
+NX_Q6UX06	Olfactomedin-4	510	57280	5.5	0	Mitochondrion;Cell membrane;Nucleoplasm;Extracellular space;Cytosol;Cytoskeleton	NA	May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.	N-glycosylated.	NA	Neutrophil degranulation	PE1	13
+NX_Q6UX07	Dehydrogenase/reductase SDR family member 13	377	40849	7.63	0	Cytoplasmic vesicle;Secreted	NA	Putative oxidoreductase.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	NA	PE1	17
+NX_Q6UX15	Layilin	382	43108	4.85	1	Membrane;Cytosol	NA	Receptor for hyaluronate.	NA	NA	NA	PE1	11
+NX_Q6UX27	V-set and transmembrane domain-containing protein 1	236	26109	4.98	1	Membrane;Cytoplasmic vesicle;Secreted	NA	Inhibitory immune receptor involved in the regulation of phagocytes.;Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).	Is N-glycosylated.	NA	NA	PE1	19
+NX_Q6UX34	Protein SNORC	121	12073	4.11	1	Cytoplasm;Extracellular matrix;Nucleolus;Membrane;Nucleoplasm	NA	Plays a role in the regulation of chondrocyte maturation and postnatal endochondral ossification. May inhibit cell growth stimulation induced by FGF2.	NA	NA	NA	PE2	2
+NX_Q6UX39	Amelotin	209	21588	5.29	0	Secreted	Amelogenesis imperfecta 3B	Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.	O-glycosylated.;Phosphorylated by FAM20C in vitro.	Belongs to the amelotin family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	4
+NX_Q6UX40	Transmembrane protein 107	140	15503	6.05	4	Cell membrane;Cilium;Membrane;Nucleoplasm;Midbody ring	Orofaciodigital syndrome 16;Meckel syndrome 13	Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474).	NA	NA	NA	PE1	17
+NX_Q6UX41	Butyrophilin-like protein 8	500	56748	8.38	1	Membrane	NA	May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.	NA	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Butyrophilin (BTN) family interactions	PE1	5
+NX_Q6UX46	ALK and LTK ligand 2	152	16915	9.75	0	Secreted	NA	Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation.	NA	Belongs to the ALKAL family.	NA	PE1	2
+NX_Q6UX52	Protein IL-40	265	29091	8.93	0	Secreted	NA	Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses. Involved in lymphocyte B cell development and immunoglobulin/IgA production.	NA	NA	NA	PE1	17
+NX_Q6UX53	Methyltransferase-like protein 7B	244	27775	8.71	0	Cytoplasmic vesicle;Cytoskeleton	NA	Probable methyltransferase.	NA	Belongs to the methyltransferase superfamily.	NA	PE1	12
+NX_Q6UX65	DNA damage-regulated autophagy modulator protein 2	266	29766	8.2	6	Golgi apparatus;Photoreceptor inner segment;Lysosome membrane;Cytoplasmic vesicle;Apical cell membrane	Cone-rod dystrophy 21	Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.	NA	Belongs to the DRAM/TMEM150 family.	NA	PE1	1
+NX_Q6UX68	XK-related protein 5	686	75014	6.21	5	Membrane	NA	NA	NA	Belongs to the XK family.	NA	PE1	8
+NX_Q6UX71	Plexin domain-containing protein 2	529	59583	5.99	1	Membrane;Nucleus	NA	May play a role in tumor angiogenesis.	NA	Belongs to the plexin family.	NA	PE1	10
+NX_Q6UX72	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9	402	43751	9.33	1	Golgi apparatus;Nucleolus;Golgi apparatus membrane	NA	NA	NA	Belongs to the glycosyltransferase 31 family.	O-linked glycosylation of mucins	PE1	16
+NX_Q6UX73	UPF0764 protein C16orf89	402	45391	5.82	0	Secreted	NA	NA	Glycosylated.	Belongs to the UPF0764 family.	NA	PE1	16
+NX_Q6UX82	Ly6/PLAUR domain-containing protein 8	237	25265	5.48	0	Secreted;Cell membrane	NA	Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.	GPI-anchored. The GPI-anchor is cleaved, leading to secretion into the colonic lumen.;Highly N-glycosylated. Not O-glycosylated.	Belongs to the CNF-like-inhibitor family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	1
+NX_Q6UX98	Probable palmitoyltransferase ZDHHC24	284	30176	9.01	5	Membrane;Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	11
+NX_Q6UXA7	Uncharacterized protein C6orf15	325	34195	7.88	0	Extracellular matrix	NA	NA	NA	NA	NA	PE1	6
+NX_Q6UXB0	Protein FAM131A	366	39503	4.59	0	Nucleolus	NA	NA	NA	Belongs to the FAM131 family.	NA	PE1	3
+NX_Q6UXB1	Insulin growth factor-like family member 3	125	14198	8.97	0	Secreted	NA	Potential ligand of the IGFLR1 cell membrane receptor.	NA	Belongs to the IGFL family.	NA	PE1	19
+NX_Q6UXB2	C-X-C motif chemokine 17	119	13819	10.97	0	Secreted	NA	4-Cys CXCL17: seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.;Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).	Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.	Belongs to the intercrine alpha (chemokine CxC) family.	NA	PE1	19
+NX_Q6UXB3	Ly6/PLAUR domain-containing protein 2	125	13115	5.69	0	Cell membrane	NA	NA	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	8
+NX_Q6UXB4	C-type lectin domain family 4 member G	293	32562	6.15	1	Cell membrane	NA	Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.;(Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV.;(Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088).;(Microbial infection) Acts as a receptor for Ebolavirus.;(Microbial infection) Acts as a receptor for Japanese encephalitis virus.	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q6UXB8	Peptidase inhibitor 16	463	49471	5.24	0	Secreted	NA	May inhibit cardiomyocyte growth.	N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.	Belongs to the CRISP family.	NA	PE1	6
+NX_Q6UXC1	Apical endosomal glycoprotein	1216	131499	5.66	1	Membrane;Nucleoplasm;Cytosol	NA	Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia.	NA	NA	NA	PE1	9
+NX_Q6UXD1	Histidine-rich carboxyl terminus protein 1	115	13183	12.13	1	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE2	9
+NX_Q6UXD5	Seizure 6-like protein 2	910	97560	4.8	1	Endoplasmic reticulum membrane;Cell membrane	NA	May contribute to specialized endoplasmic reticulum functions in neurons.	O-glycosylated with core 1 or possibly core 8 glycans.	Belongs to the SEZ6 family.	NA	PE1	16
+NX_Q6UXD7	Solute carrier family 49 member A3	560	58427	6.45	12	Membrane	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE1	4
+NX_Q6UXE8	Butyrophilin-like protein 3	466	52251	5.84	1	Membrane	NA	NA	NA	Belongs to the immunoglobulin superfamily. BTN/MOG family.	NA	PE1	5
+NX_Q6UXF1	Transmembrane protein 108	575	59948	9.62	2	Cell membrane;Endosome membrane;Early endosome;Nucleolus;Membrane;Postsynaptic density;Cytoplasmic vesicle;Cytosol;Axon;Dendrite	NA	Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.	Glycosylated.	NA	NA	PE1	3
+NX_Q6UXF7	C-type lectin domain family 18 member B	455	50490	8.39	0	Golgi apparatus;Endoplasmic reticulum;Endosome;Secreted	NA	Binds polysaccharides in a Ca(2+)-independent manner (By similarity).	NA	NA	NA	PE2	16
+NX_Q6UXG2	UPF0577 protein KIAA1324	1013	111382	6.13	1	Lysosome membrane;trans-Golgi network membrane;Late endosome membrane;Cell membrane	NA	May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway.	NA	Belongs to the UPF0577 family.	NA	PE1	1
+NX_Q6UXG3	CMRF35-like molecule 9	332	36060	5.68	1	Basolateral cell membrane;Apical cell membrane;Multivesicular body membrane	NA	Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).	O-glycosylated with sialylated oligosaccharides.	Belongs to the CD300 family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	17
+NX_Q6UXG8	Butyrophilin-like protein 9	535	59716	6	1	Membrane;Cytoplasmic vesicle;Nucleus membrane	NA	NA	NA	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Butyrophilin (BTN) family interactions	PE1	5
+NX_Q6UXH0	Angiopoietin-like protein 8	198	22105	7.08	0	Golgi apparatus;Nucleoplasm;Secreted	Diabetes mellitus, insulin-dependent;Diabetes mellitus, non-insulin-dependent	Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).	Proteolytically cleaved at the N-terminus.	Belongs to the ANGPTL8 family.	Assembly of active LPL and LIPC lipase complexes	PE1	19
+NX_Q6UXH1	Protein disulfide isomerase CRELD2	353	38192	4.5	0	Endoplasmic reticulum	NA	Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698).	NA	Belongs to the CRELD family.	NA	PE1	22
+NX_Q6UXH8	Collagen and calcium-binding EGF domain-containing protein 1	406	44103	7.74	0	Cytosol;Secreted;Cell membrane	Hennekam lymphangiectasia-lymphedema syndrome 1	Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.	NA	Belongs to the CCBE1 family.	NA	PE1	18
+NX_Q6UXH9	Inactive serine protease PAMR1	720	80199	7.57	0	Secreted	NA	May play a role in regeneration of skeletal muscle.	NA	Belongs to the peptidase S1 family.	NA	PE1	11
+NX_Q6UXI7	Vitrin	678	73930	9.29	0	Extracellular matrix	NA	Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells.	NA	NA	NA	PE1	2
+NX_Q6UXI9	Nephronectin	565	61907	8.74	0	Nucleoplasm;Cytosol;Cell junction;Extracellular matrix	NA	Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).	NA	Belongs to the nephronectin family.	NA	PE1	4
+NX_Q6UXK2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	745	78990	5.17	1	Cell membrane	NA	Required for axon extension during neural development.	NA	NA	NA	PE1	15
+NX_Q6UXK5	Leucine-rich repeat neuronal protein 1	716	80716	5.77	1	Membrane	NA	NA	NA	NA	NA	PE1	3
+NX_Q6UXL0	Interleukin-20 receptor subunit beta	311	35076	4.98	1	Membrane;Cytoplasmic vesicle;Cytosol	NA	The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.	NA	Belongs to the type II cytokine receptor family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling	PE1	3
+NX_Q6UXM1	Leucine-rich repeats and immunoglobulin-like domains protein 3	1119	123434	5.79	1	Cytoplasmic vesicle membrane;Cytosol;Cell membrane	NA	May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).	NA	NA	NA	PE1	12
+NX_Q6UXN2	Trem-like transcript 4 protein	200	21924	8.87	0	Secreted	NA	Positively regulates Toll-like receptor TLR7 signaling in macrophages.	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE2	6
+NX_Q6UXN7	TOMM20-like protein 1	152	17700	8.87	1	Mitochondrion outer membrane	NA	NA	NA	Belongs to the Tom20 family.	NA	PE1	14
+NX_Q6UXN8	C-type lectin domain family 9 member A	241	27324	6.42	1	Membrane	NA	Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.	N-glycosylated.	NA	NA	PE1	12
+NX_Q6UXN9	WD repeat-containing protein 82	313	35079	7.59	0	Nucleolus;Nucleus	NA	Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.	NA	Belongs to the WD repeat SWD2 family.	NA	PE1	3
+NX_Q6UXP3	Transmembrane protein 14EP	125	13608	8.46	2	Membrane	NA	NA	NA	Belongs to the TMEM14 family.	NA	PE5	3
+NX_Q6UXP7	Protein FAM151B	276	31367	5.6	0	Cytosol	NA	NA	NA	Belongs to the FAM151 family.	NA	PE1	5
+NX_Q6UXP9	Putative uncharacterized protein UNQ9370/PRO34162	181	19777	9.67	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_Q6UXQ4	Uncharacterized protein C2orf66	117	13321	9.57	0	Secreted	NA	NA	NA	NA	NA	PE2	2
+NX_Q6UXQ8	Putative uncharacterized protein UNQ6190/PRO20217	127	13410	11.87	0	Secreted	NA	NA	NA	NA	NA	PE5	15
+NX_Q6UXR4	Putative serpin A13	307	34864	5.95	0	Secreted	NA	NA	NA	Belongs to the serpin family.	NA	PE5	14
+NX_Q6UXR6	Putative uncharacterized protein UNQ6494/PRO21346	183	19530	6.19	0	Secreted	NA	NA	NA	NA	NA	PE5	9
+NX_Q6UXR8	Putative uncharacterized protein UNQ6493/PRO21345	122	12794	7.65	0	NA	NA	NA	NA	NA	NA	PE5	19
+NX_Q6UXS0	C-type lectin domain family 19 member A	136	15448	6.17	0	Secreted	NA	NA	NA	NA	NA	PE2	16
+NX_Q6UXS9	Inactive caspase-12	341	38907	5.63	0	NA	NA	Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.	NA	Belongs to the peptidase C14A family.	NA	PE1	11
+NX_Q6UXT8	ALK and LTK ligand 1	129	14269	10.6	0	Secreted	NA	Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly.	NA	Belongs to the ALKAL family.	NA	PE1	8
+NX_Q6UXT9	Protein ABHD15	468	51771	7.57	0	Nucleoplasm;Cytosol;Secreted	NA	NA	NA	Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.	NA	PE1	17
+NX_Q6UXU0	Putative uncharacterized protein UNQ9165/PRO28630	137	14541	10.84	0	Secreted	NA	NA	NA	NA	NA	PE2	19
+NX_Q6UXU4	Germ cell-specific gene 1-like protein	331	36774	6.59	4	Synapse;Cell membrane	NA	As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating.	NA	Belongs to the GSG1 family.	NA	PE1	16
+NX_Q6UXU6	Transmembrane protein 92	159	17229	5.48	1	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	17
+NX_Q6UXV0	GDNF family receptor alpha-like	394	44518	8.28	1	Cell membrane	NA	Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.	NA	Belongs to the GDNFR family.	NA	PE1	6
+NX_Q6UXV1	Izumo sperm-egg fusion protein 2	221	24856	9.07	1	Membrane	NA	NA	NA	Belongs to the Izumo family.	Acrosome Reaction and Sperm:Oocyte Membrane Binding	PE1	19
+NX_Q6UXV3	Uncharacterized protein UNQ6126/PRO20091	157	16883	5.18	0	Secreted	NA	NA	NA	NA	NA	PE2	22
+NX_Q6UXV4	MICOS complex subunit MIC27	268	29159	9.55	2	Mitochondrion inner membrane;Mitochondrion	NA	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979).	NA	Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.	Platelet degranulation;Cristae formation	PE1	X
+NX_Q6UXX5	Inter-alpha-trypsin inhibitor heavy chain H6	1313	143187	9.1	0	Secreted	NA	NA	NA	Belongs to the ITIH family.	NA	PE1	X
+NX_Q6UXX9	R-spondin-2	243	28315	9.42	0	Secreted	Humerofemoral hypoplasia with radiotibial ray deficiency;Tetraamelia syndrome 2	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21909076, PubMed:21727895, PubMed:22615920). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720).	NA	Belongs to the R-spondin family.	Regulation of FZD by ubiquitination	PE1	8
+NX_Q6UXY1	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2	529	58987	9.53	0	Cytoplasmic vesicle membrane;Cell junction;Cell membrane	NA	Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).	NA	NA	NA	PE1	22
+NX_Q6UXY8	Transmembrane channel-like protein 5	1006	114797	8.46	10	Membrane;Nucleoplasm;Cell membrane	NA	Probable ion channel.	NA	Belongs to the TMC family.	NA	PE1	16
+NX_Q6UXZ0	Transmembrane and immunoglobulin domain-containing protein 1	262	29185	8.07	1	Cytoplasm;Mitochondrion;Cell membrane	NA	May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival.	N-glycosylated.	NA	NA	PE1	17
+NX_Q6UXZ3	CMRF35-like molecule 5	194	21558	9.12	1	Cell membrane	NA	NA	N-glycosylated.	Belongs to the CD300 family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	17
+NX_Q6UXZ4	Netrin receptor UNC5D	953	105880	5.71	1	Cell membrane	NA	Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).	Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.	Belongs to the unc-5 family.	Axon guidance;Netrin mediated repulsion signals	PE1	8
+NX_Q6UY01	Leucine-rich repeat-containing protein 31	552	61489	5.71	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_Q6UY09	Carcinoembryonic antigen-related cell adhesion molecule 20	596	65808	5.49	1	Apical cell membrane;Microvillus membrane	NA	Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response.	Phosphorylated on tyrosine residues by SYK, SRC and FYN in vitro.	Belongs to the immunoglobulin superfamily. CEA family.	NA	PE1	19
+NX_Q6UY11	Protein delta homolog 2	383	40548	6.09	1	Membrane;Nucleoplasm;Nucleolus;Cytoplasmic vesicle	NA	Regulates adipogenesis.	NA	NA	NA	PE1	6
+NX_Q6UY13	Putative uncharacterized protein UNQ5830/PRO19650/PRO19816	95	10734	9.78	0	Secreted	NA	NA	NA	NA	NA	PE3	2
+NX_Q6UY14	ADAMTS-like protein 4	1074	116545	8.79	0	Cytosol;Extracellular matrix;Cell membrane	Ectopia lentis 2, isolated, autosomal recessive;Ectopia lentis et pupillae	Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis.	N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion (By similarity).	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	1
+NX_Q6UY18	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4	593	63774	8.53	1	Membrane	NA	NA	NA	NA	NA	PE2	1
+NX_Q6UY27	Prostate and testis expressed protein 2	113	13015	6.91	0	Secreted	NA	NA	NA	Belongs to the PATE family.	NA	PE1	11
+NX_Q6UYE1	Leukemia-associated protein 7	221	23924	7.77	0	NA	NA	NA	NA	NA	NA	PE1	13
+NX_Q6V0I7	Protocadherin Fat 4	4981	542687	4.77	1	Membrane;Cytosol	Van Maldergem syndrome 2;Hennekam lymphangiectasia-lymphedema syndrome 2	Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).	NA	NA	NA	PE1	4
+NX_Q6V0L0	Cytochrome P450 26C1	522	57111	9.24	1	Membrane	Focal facial dermal dysplasia 4	Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).	NA	Belongs to the cytochrome P450 family.	Retinol metabolism;RA biosynthesis pathway;Vitamins;Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)	PE1	10
+NX_Q6V1P9	Protocadherin-23	2916	322234	4.63	1	Membrane;Cytoplasmic vesicle;Cell membrane	NA	Calcium-dependent cell-adhesion protein.	NA	NA	NA	PE1	4
+NX_Q6V1X1	Dipeptidyl peptidase 8	898	103358	5.52	0	Cytoplasm;Cytosol	NA	Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.	NA	Belongs to the peptidase S9B family. DPPIV subfamily.	NA	PE1	15
+NX_Q6V702	Cilia- and flagella-associated protein 299	233	26869	5.28	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	May be involved in spermatogenesis.	NA	NA	NA	PE1	4
+NX_Q6V9R5	Zinc finger protein 562	426	48563	8.76	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6VAB6	Kinase suppressor of Ras 2	950	107632	8.95	0	Membrane;Cytoplasm	NA	Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.	Phosphorylated on Ser-474 by MARK3.	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	MAP2K and MAPK activation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	12
+NX_Q6VB84	Forkhead box protein D4-like 3	417	45820	9.82	0	Nucleus	NA	NA	NA	NA	NA	PE2	9
+NX_Q6VEQ5	WAS protein family homolog 2	465	50312	5.53	0	Centriole;Autophagosome;Recycling endosome membrane;Late endosome;Early endosome membrane	NA	Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity).	NA	Belongs to the WASH1 family.	NA	PE2	2
+NX_Q6VMQ6	Activating transcription factor 7-interacting protein 1	1270	136394	4.58	0	Nucleoplasm;Nucleus	NA	Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100).	NA	Belongs to the MCAF family.	PKMTs methylate histone lysines	PE1	12
+NX_Q6VN20	Ran-binding protein 10	620	67257	6.29	0	Cytosol;Nucleus	NA	May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity).	NA	Belongs to the RANBP9/10 family.	MET activates RAS signaling	PE1	16
+NX_Q6VUC0	Transcription factor AP-2-epsilon	442	46212	8.64	0	Nucleus	NA	Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).	NA	Belongs to the AP-2 family.	Activation of the TFAP2 (AP-2) family of transcription factors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors	PE2	1
+NX_Q6VVB1	E3 ubiquitin-protein ligase NHLRC1	395	42293	6.99	0	Endoplasmic reticulum;Nucleus;Cytoplasmic vesicle	Epilepsy, progressive myoclonic 2	E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.	NA	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Glycogen synthesis;Myoclonic epilepsy of Lafora	PE1	6
+NX_Q6VVX0	Vitamin D 25-hydroxylase	501	57359	7.25	0	Microsome membrane;Endoplasmic reticulum membrane	Rickets vitamin D-dependent 1B	Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).	NA	Belongs to the cytochrome P450 family.	Hormone biosynthesis; vitamin D biosynthesis.;Steroid biosynthesis;Metabolic pathways;Vitamin D (calciferol) metabolism;Vitamins;Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)	PE1	11
+NX_Q6VY07	Phosphofurin acidic cluster sorting protein 1	963	104898	7.6	0	trans-Golgi network;Cytosol;Cytoskeleton	Schuurs-Hoeijmakers syndrome	Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.	NA	Belongs to the PACS family.	Nef mediated downregulation of MHC class I complex cell surface expression	PE1	11
+NX_Q6W0C5	Developmental pluripotency-associated protein 3	159	17851	8.86	0	Cytoplasm;Nucleus	NA	Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).	NA	NA	NA	PE1	12
+NX_Q6W2J9	BCL-6 corepressor	1755	192189	6.06	0	Nucleoplasm;Nucleus	Microphthalmia, syndromic, 2	Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).	NA	Belongs to the BCOR family.	NA	PE1	X
+NX_Q6W349	Putative uncharacterized protein encoded by LINC00575	94	10157	5.34	0	NA	NA	NA	NA	NA	NA	PE5	4
+NX_Q6W3E5	Glycerophosphodiester phosphodiesterase domain-containing protein 4	623	71996	9.16	6	Membrane	NA	NA	NA	Belongs to the glycerophosphoryl diester phosphodiesterase family.	NA	PE2	11
+NX_Q6W4X9	Mucin-6	2439	257051	7.22	0	Secreted	NA	May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.	O-glycosylated.	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	11
+NX_Q6W5P4	Neuropeptide S receptor	371	42687	8.63	7	Cytoplasm;Cell membrane	Asthma-related traits 2	G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.	NA	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	Peptide ligand-binding receptors;G alpha (q) signalling events;G alpha (s) signalling events	PE1	7
+NX_Q6WBX8	Cell cycle checkpoint control protein RAD9B	426	47832	6.47	0	NA	NA	NA	NA	Belongs to the rad9 family.	Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	12
+NX_Q6WCQ1	Myosin phosphatase Rho-interacting protein	1025	116533	5.89	0	Cytosol;Cytoskeleton	NA	Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.	NA	NA	Signaling by BRAF and RAF fusions	PE1	17
+NX_Q6WKZ4	Rab11 family-interacting protein 1	1283	137167	5.3	0	Recycling endosome;Phagosome membrane;Cytoplasmic vesicle	NA	A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.	NA	NA	Endocytosis	PE1	8
+NX_Q6WN34	Chordin-like protein 2	429	47495	8.23	0	Cytoplasm;Secreted	NA	May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.	Phosphorylated by FAM20C in the extracellular medium.	NA	NA	PE1	11
+NX_Q6WQI6	Putative cancer susceptibility gene HEPN1 protein	88	10305	8.04	0	Golgi apparatus;Cytoplasm	NA	NA	NA	NA	NA	PE5	11
+NX_Q6WRI0	Immunoglobulin superfamily member 10	2623	290838	9.25	0	Nucleoplasm;Secreted;Cytoskeleton	NA	Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity).	NA	NA	NA	PE1	3
+NX_Q6WRX3	Protein zyg-11 homolog A	759	85808	8.3	0	Nucleoplasm	NA	Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.	NA	Belongs to the zyg-11 family.	NA	PE1	1
+NX_Q6X4T0	Uncharacterized protein C12orf54	127	14485	8.66	0	Cytoskeleton	NA	NA	NA	NA	NA	PE2	12
+NX_Q6X4U4	Sclerostin domain-containing protein 1	206	23307	9.81	0	Secreted	NA	May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.	NA	Belongs to the sclerostin family.	NA	PE1	7
+NX_Q6X4W1	NMDA receptor synaptonuclear signaling and neuronal migration factor	530	60143	9.19	0	Cytoplasm;Cell cortex;Synaptosome;Cell membrane;Nucleus matrix;Nucleus membrane;Membrane;Nucleoplasm;Nucleus envelope;Postsynaptic density;Synapse;Dendrite;Nucleus;Cytoskeleton	Hypogonadotropic hypogonadism 9 with or without anosmia	Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.	Proteolytically processed after NMDA receptor activation. Cleaved in a calcium-dependent and calpain-sensitive manner. Calpain cleavage is essential for the translocation process from dendrites to the nucleus (By similarity).	Belongs to the NSMF family.	NA	PE1	9
+NX_Q6X784	Zona pellucida-binding protein 2	338	38652	8.04	0	Secreted;Acrosome	NA	Is implicated in sperm-oocyte interaction during fertilization.	N-glycosylated.	Belongs to the zona pellucida-binding protein Sp38 family.	NA	PE1	17
+NX_Q6X9E4	F-box/WD repeat-containing protein 12	464	53056	7.85	0	NA	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	3
+NX_Q6XCG6	Putative uncharacterized protein PP632	107	11455	7.94	0	NA	NA	NA	NA	NA	NA	PE4	1
+NX_Q6XD76	Achaete-scute homolog 4	172	19253	9.23	0	Nucleus	NA	Could be a transcriptional regulator involved in skin development.	NA	NA	NA	PE1	12
+NX_Q6XE24	RNA-binding motif, single-stranded-interacting protein 3	437	47840	8.12	0	Cytoplasm;Cytoplasmic vesicle	NA	Binds poly(A) and poly(U) oligoribonucleotides.	NA	NA	NA	PE1	3
+NX_Q6XE38	Secretoglobin family 1D member 4	83	9201	9.14	0	Secreted	NA	Seems to be involved in the regulation of chemotactic cell migration and invasion.	NA	Belongs to the secretoglobin family. Lipophilin subfamily.	NA	PE1	11
+NX_Q6XLA1	Protein CASC2, isoform 3	102	11902	8.53	0	NA	NA	May act as a potential tumor suppressor.	NA	NA	NA	PE2	10
+NX_Q6XPR3	Repetin	784	90731	6.42	0	Extracellular matrix	NA	Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium.	Potential substrate of transglutaminase. Some arginines are probably converted to citrullines by peptidylarginine deimidase.	Belongs to the S100-fused protein family.	Formation of the cornified envelope	PE1	1
+NX_Q6XPS3	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2	522	61112	8.8	3	Cytoplasm;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate.;Shows no phosphoinositide phosphatase activity.	NA	NA	Synthesis of PIPs at the Golgi membrane	PE1	13
+NX_Q6XQN6	Nicotinate phosphoribosyltransferase	538	57578	5.51	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275).	Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.	Belongs to the NAPRTase family.	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.;Nicotinate and nicotinamide metabolism;Metabolic pathways;Nicotinamide salvaging;Neutrophil degranulation	PE1	8
+NX_Q6XR72	Zinc transporter 10	485	52684	6.28	6	trans-Golgi network;Recycling endosome;Early endosome;Cell membrane	Hypermanganesemia with dystonia 1	Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971, PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells (PubMed:22706290, PubMed:22427991, PubMed:26728129).	NA	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.	Metal ion SLC transporters	PE1	1
+NX_Q6XUX3	Dual serine/threonine and tyrosine protein kinase	929	105206	6.29	0	Cytoplasm;Nucleus speckle;Cell membrane;Basolateral cell membrane;Cell junction;Apical cell membrane;Cytoskeleton	Spastic paraplegia 23, autosomal recessive;Congenital anomalies of the kidney and urinary tract 1	Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540).	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	1
+NX_Q6XXX2	Putative uncharacterized protein encoded by LINC00114	140	15753	9.79	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_Q6XYB7	Transcription factor LBX2	198	21482	8.95	0	Nucleoplasm;Nucleus;Midbody	NA	Putative transcription factor.	NA	NA	NA	PE2	2
+NX_Q6XYQ8	Synaptotagmin-10	523	59127	7.57	1	Cytoplasmic vesicle;Nucleoplasm;Secretory vesicle membrane	NA	Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).	NA	Belongs to the synaptotagmin family.	Neurexins and neuroligins	PE1	12
+NX_Q6XZB0	Lipase member I	460	52922	9.18	0	Membrane;Secreted	Hypertriglyceridemia, familial	Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Synthesis of PA	PE1	21
+NX_Q6XZF7	Dynamin-binding protein	1577	177347	5.26	0	Golgi apparatus;Cytoplasm;Cell junction;Nucleolus;Synapse;Cytosol;Golgi stack;Nucleus;Cytoskeleton	Cataract 48	Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Play a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).	NA	NA	NA	PE1	10
+NX_Q6Y1H2	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2	254	28368	9.56	6	Endoplasmic reticulum membrane	NA	Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.	NA	Belongs to the very long-chain fatty acids dehydratase HACD family.	Lipid metabolism; fatty acid biosynthesis.;Fatty acid elongation;Biosynthesis of unsaturated fatty acids;Synthesis of very long-chain fatty acyl-CoAs	PE1	3
+NX_Q6Y288	Beta-1,3-glucosyltransferase	498	56564	7.23	1	Endoplasmic reticulum membrane	Peters-plus syndrome	O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	13
+NX_Q6Y2X3	DnaJ homolog subfamily C member 14	702	78569	8.37	3	Endoplasmic reticulum membrane	NA	Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.	NA	NA	NA	PE1	12
+NX_Q6Y7W6	GRB10-interacting GYF protein 2	1299	150070	5.45	0	Cytosol	Parkinson disease 11	Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153).	NA	Belongs to the GIGYF family.	NA	PE1	2
+NX_Q6YBV0	Proton-coupled amino acid transporter 4	504	56157	6.6	10	Membrane;Golgi apparatus;Cytosol;Cell membrane	NA	Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine.	NA	Belongs to the amino acid/polyamine transporter 2 family.	Tryptophan catabolism;Amino acid transport across the plasma membrane	PE1	11
+NX_Q6YFQ2	Cytochrome c oxidase subunit 6B2	88	10529	9.21	0	Nucleoplasm;Cytosol;Mitochondrion intermembrane space;Cell membrane	NA	Connects the two COX monomers into the physiological dimeric form.	NA	Belongs to the cytochrome c oxidase subunit 6B family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease	PE1	19
+NX_Q6YHK3	CD109 antigen	1445	161689	5.59	0	Endoplasmic reticulum;Cell membrane	NA	Modulates negatively TGFB1 signaling in keratinocytes.	N-glycosylated.;2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.	Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.	Platelet degranulation;Post-translational modification: synthesis of GPI-anchored proteins	PE1	6
+NX_Q6YHU6	Thyroid adenoma-associated protein	1953	219607	5.71	0	Cytosol	NA	NA	NA	Belongs to the THADA family.	tRNA modification in the nucleus and cytosol	PE1	2
+NX_Q6YI46	Transmembrane protein 64	380	39665	8.78	6	Membrane;Endoplasmic reticulum	NA	Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.	NA	Belongs to the TVP38/TMEM64 family.	NA	PE1	8
+NX_Q6YN16	Hydroxysteroid dehydrogenase-like protein 2	418	45395	8.07	0	Peroxisome;Mitochondrion	NA	Has apparently no steroid dehydrogenase activity.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	NA	PE1	9
+NX_Q6YP21	Kynurenine--oxoglutarate transaminase 3	454	51400	8.4	0	Cytosol;Nucleolus	NA	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).	NA	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	Tryptophan metabolism;Selenocompound metabolism;Metabolic pathways;Tryptophan catabolism	PE1	1
+NX_Q6ZMB0	Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase	384	42748	7.65	1	Golgi apparatus membrane	NA	Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs.	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	11
+NX_Q6ZMB5	Transmembrane protein 184A	413	45777	8.4	7	Cell membrane;Nucleoplasm;Endosome;Cytoplasmic vesicle membrane;Secretory vesicle membrane;Early endosome membrane;Perinuclear region	NA	Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity).	NA	Belongs to the TMEM184 family.	NA	PE1	7
+NX_Q6ZMC9	Sialic acid-binding Ig-like lectin 15	328	35653	8.86	1	Membrane;Nucleoplasm;Golgi apparatus	NA	Binds sialylated glycoproteins.	NA	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	DAP12 interactions	PE1	18
+NX_Q6ZMD2	Protein spinster homolog 3	512	54769	6.14	12	Membrane	NA	Sphingolipid transporter.	NA	Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.	NA	PE1	17
+NX_Q6ZMG9	Ceramide synthase 6	384	44890	7.56	5	Nucleoplasm;Endoplasmic reticulum membrane	NA	Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952). Can use other acyl donors, but with less efficiency (By similarity). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity).	Phosphorylated at the C-terminus by CK2.;Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation.	NA	Lipid metabolism; sphingolipid metabolism.;Sphingolipid de novo biosynthesis	PE1	2
+NX_Q6ZMH5	Zinc transporter ZIP5	540	56461	6.33	6	Nucleoplasm;Basolateral cell membrane;Cytoplasmic vesicle	Myopia 24, autosomal dominant	May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status (By similarity).	Glycosylated.	Belongs to the ZIP transporter (TC 2.A.5) family.	Zinc influx into cells by the SLC39 gene family	PE1	12
+NX_Q6ZMI0	Protein phosphatase 1 regulatory subunit 21	780	88314	6.4	0	Nucleoplasm;Early endosome;Cytoplasmic vesicle	NA	Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (PubMed:30520571).	NA	NA	NA	PE1	2
+NX_Q6ZMI3	Gliomedin	551	58957	8.1	1	Axon;Extracellular matrix;Secreted;Cell membrane	Lethal congenital contracture syndrome 11	Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.	Proteolytic proccessing by a furin-like protease causes shedding of the ectodomain. Further cleavage by BMP1 releases the olfactomedin-like domain.;N-glycosylated.	NA	NA	PE1	15
+NX_Q6ZMJ2	Scavenger receptor class A member 5	495	53994	6.65	1	Cell membrane	NA	Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).	NA	Belongs to the SCARA5 family.	Scavenging by Class A Receptors	PE1	8
+NX_Q6ZMJ4	Interleukin-34	242	27482	6.82	0	Secreted	NA	Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.	NA	Belongs to the IL-34 family.	Other interleukin signaling	PE1	16
+NX_Q6ZMK1	Cysteine and histidine-rich protein 1	362	40703	6.87	0	Cytoplasm;Nucleoplasm;Perinuclear region	NA	NA	NA	Belongs to the CYHR1 family.	NA	PE1	8
+NX_Q6ZMM2	ADAMTS-like protein 5	481	53193	8.59	0	Golgi apparatus;Extracellular matrix;Secreted	NA	May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM).	Proteolytically cleaved to release a C-terminal fragment containing the NTR domain.;Contains at least one additional N-linked glycosylation site.	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	19
+NX_Q6ZMN7	PDZ domain-containing RING finger protein 4	1036	117103	5.61	0	NA	NA	NA	NA	NA	NA	PE1	12
+NX_Q6ZMN8	Cyclin-I2	369	40622	8.07	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the cyclin family.	NA	PE1	5
+NX_Q6ZMP0	Thrombospondin type-1 domain-containing protein 4	1018	112450	7.94	0	Extracellular matrix	NA	Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity).	NA	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	15
+NX_Q6ZMQ8	Serine/threonine-protein kinase LMTK1	1374	144569	4.48	1	Membrane;Cytoplasm;Mitochondrion;Perinuclear region	NA	May be involved in neuronal differentiation.	Autophosphorylated. Phosphorylated by CDK5.;Autophosphorylated (Phosphoserine,Phosphotyrosine:PTM-0253,PTM-0255)	Belongs to the protein kinase superfamily. Tyr protein kinase family.	NA	PE1	17
+NX_Q6ZMR3	L-lactate dehydrogenase A-like 6A	332	36507	6.51	0	Cytoplasm	NA	Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.	NA	Belongs to the LDH/MDH superfamily. LDH family.	Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.;Glycolysis / Gluconeogenesis;Cysteine and methionine metabolism;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Pyruvate metabolism	PE1	11
+NX_Q6ZMR5	Transmembrane protease serine 11A	421	47569	9.32	1	Membrane	NA	Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.	NA	Belongs to the peptidase S1 family.	NA	PE1	4
+NX_Q6ZMS4	Zinc finger protein 852	543	62084	8.45	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q6ZMS7	Protein ZNF783	281	31422	4.9	0	Cytosol;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	7
+NX_Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	411	45009	7.03	0	Cytosol;Sarcolemma;Cell membrane	NA	Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.	NA	NA	NA	PE1	17
+NX_Q6ZMT4	Lysine-specific demethylase 7A	941	106557	8.34	0	Nucleoplasm;Nucleolus;Nucleus	NA	Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.	NA	Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.	HDMs demethylate histones;Signaling by BRAF and RAF fusions	PE1	7
+NX_Q6ZMT9	Death domain-containing protein 1	781	88329	6.81	0	NA	NA	NA	NA	NA	NA	PE1	4
+NX_Q6ZMU1	Putative protein C3P1	363	40197	6.32	0	NA	NA	NA	NA	NA	NA	PE5	19
+NX_Q6ZMU5	Tripartite motif-containing protein 72	477	52731	6.05	0	Nucleoplasm;Sarcolemma;Cytoplasmic vesicle membrane;Cytoplasmic vesicle	NA	Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).	Disulfide bond formation at Cys-242 occurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization.;S-nitrosylation at Cys-144 stabilizes TRIM72 and protects against oxidation-induced protein degradation and cell death.	Belongs to the TRIM/RBCC family.	Smooth Muscle Contraction	PE1	16
+NX_Q6ZMV5	Protein PPP4R3C	832	95804	4.72	0	NA	NA	NA	NA	Belongs to the SMEK family.	NA	PE1	X
+NX_Q6ZMV7	Leucine-, glutamate- and lysine-rich protein 1	388	45158	6.29	0	NA	NA	NA	NA	NA	NA	PE2	3
+NX_Q6ZMV8	Putative zinc finger protein 730	503	59040	9.48	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q6ZMV9	Kinesin-like protein KIF6	814	92569	6.47	0	Centrosome;Cytoskeleton	NA	NA	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	6
+NX_Q6ZMW2	Zinc finger protein 782	699	80904	9.21	0	Nucleoplasm;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	9
+NX_Q6ZMW3	Echinoderm microtubule-associated protein-like 6	1958	217899	7.17	0	Cytoplasmic vesicle;Mitochondrion;Cytoskeleton	NA	May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.	NA	Belongs to the WD repeat EMAP family.	NA	PE1	2
+NX_Q6ZMY3	SPOC domain-containing protein 1	1216	130027	6.82	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	1
+NX_Q6ZMY6	WD repeat-containing protein 88	472	52621	6.98	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q6ZMY9	Zinc finger protein 517	492	54711	9.26	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	8
+NX_Q6ZMZ0	E3 ubiquitin-protein ligase RNF19B	732	77925	5.81	2	Cytosol;Cytoplasmic granule membrane;Endoplasmic reticulum membrane	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036).	NA	Belongs to the RBR family. RNF19 subfamily.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	1
+NX_Q6ZMZ3	Nesprin-3	975	112216	5.88	1	Nucleus outer membrane;Nucleus envelope;Nucleus membrane;Rough endoplasmic reticulum	NA	As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.	The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces.	Belongs to the nesprin family.	NA	PE1	14
+NX_Q6ZN01	MEF2-activating motif and SAP domain-containing transcriptional regulator	415	44632	6.57	0	Nucleus speckle;Nucleus	NA	Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity).	NA	NA	NA	PE1	19
+NX_Q6ZN03	Putative uncharacterized protein encoded by LINC00322	302	32374	9.1	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_Q6ZN04	RNA-binding protein MEX3B	569	58832	6.44	0	Cytoplasm;Nucleoplasm;P-body;Cytosol;Cytoplasmic granule;Nucleus	NA	RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.	Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.	NA	NA	PE1	15
+NX_Q6ZN06	Zinc finger protein 813	617	71721	9.5	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q6ZN08	Putative zinc finger protein 66	573	65874	9.46	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE5	19
+NX_Q6ZN11	Zinc finger protein 793	406	46927	9.48	0	Nucleus;Nucleoplasm;Cytosol;Nucleolus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q6ZN16	Mitogen-activated protein kinase kinase kinase 15	1313	147437	5.42	0	Cytoplasmic vesicle	NA	May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	NA	PE1	X
+NX_Q6ZN17	Protein lin-28 homolog B	250	27084	9.15	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Has no effect on cell growth.;Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7.	NA	Belongs to the lin-28 family.	NA	PE1	6
+NX_Q6ZN18	Zinc finger protein AEBP2	517	54467	5.1	0	Nucleoplasm;Nucleus	NA	DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.	NA	Belongs to the AEBP2/jing C2H2-type zinc-finger family.	PKMTs methylate histone lysines;PRC2 methylates histones and DNA	PE1	12
+NX_Q6ZN19	Zinc finger protein 841	808	93148	9.48	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q6ZN28	Metastasis-associated in colon cancer protein 1	852	96639	6.43	0	Cytoplasm;Mitochondrion;Nucleus	NA	Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.	NA	NA	NA	PE1	7
+NX_Q6ZN30	Zinc finger protein basonuclin-2	1099	122330	6.07	0	Nucleoplasm;Nucleus	NA	Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes.	NA	NA	NA	PE1	9
+NX_Q6ZN32	ETS translocation variant 3-like protein	361	39948	9	0	Nucleus	NA	Transcriptional regulator.	NA	Belongs to the ETS family.	NA	PE2	1
+NX_Q6ZN44	Netrin receptor UNC5A	842	92932	6.33	1	Cytosol;Neuron projection;Membrane raft;Cell membrane	NA	Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.	Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.;Phosphorylated on cytoplasmic tyrosine residues (By similarity). Phosphorylated by PKC in vitro (By similarity).	Belongs to the unc-5 family.	Axon guidance;Netrin-1 signaling;Caspase activation via Dependence Receptors in the absence of ligand;Netrin mediated repulsion signals	PE1	5
+NX_Q6ZN54	Differentially expressed in FDCP 8 homolog	512	58710	6.09	0	Nucleoplasm;Cytosol	NA	Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.	NA	Belongs to the DEF8 family.	NA	PE1	16
+NX_Q6ZN55	Zinc finger protein 574	896	98900	8.44	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q6ZN57	Zinc finger protein 2 homolog	461	52740	8.91	0	Nucleus	NA	Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	5
+NX_Q6ZN66	Guanylate-binding protein 6	633	72427	5.98	0	NA	NA	Binds GTP, GDP and GMP.	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	Interferon gamma signaling	PE1	1
+NX_Q6ZN68	Putative C-mannosyltransferase DPY19L2P2	376	43060	8.74	6	Membrane;Endoplasmic reticulum	NA	Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.	NA	Belongs to the dpy-19 family.	NA	PE5	7
+NX_Q6ZN79	Zinc finger protein 705A	300	34734	9.36	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	12
+NX_Q6ZN84	Coiled-coil domain-containing protein 81	652	76084	9.25	0	Centrosome	NA	NA	NA	NA	NA	PE1	11
+NX_Q6ZN92	Putative inactive deoxyuridine 5'-triphosphate nucleotidohydrolase-like protein FLJ16323	141	15492	7.06	0	NA	NA	NA	NA	Belongs to the dUTPase family.	NA	PE5	9
+NX_Q6ZNA1	Zinc finger protein 836	936	107717	9.39	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	994	108862	6.67	0	Cytoplasm;Nucleoplasm;PML body;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).	NA	Belongs to the Arkadia family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Formation of Incision Complex in GG-NER	PE1	15
+NX_Q6ZNA5	Ferric-chelate reductase 1	592	66114	7.11	7	Membrane	NA	Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.	NA	Belongs to the FRRS1 family.	NA	PE1	1
+NX_Q6ZNB5	Putative short transient receptor potential channel 2-like protein	142	15763	8.53	0	Nucleolus	NA	NA	NA	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.	NA	PE5	11
+NX_Q6ZNB6	NF-X1-type zinc finger protein NFXL1	911	101339	8.85	1	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the NFX1 family.	NA	PE1	4
+NX_Q6ZNB7	Alkylglycerol monooxygenase	445	51500	7.75	5	Cytoplasmic vesicle;Endoplasmic reticulum membrane	NA	Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.	NA	Belongs to the sterol desaturase family. TMEM195 subfamily.	Triglyceride biosynthesis	PE1	7
+NX_Q6ZNC4	Zinc finger protein 704	412	45276	8.8	0	Nucleoplasm;Nucleus	NA	Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer.	NA	NA	Generic Transcription Pathway	PE1	8
+NX_Q6ZNC8	Lysophospholipid acyltransferase 1	495	56557	9.33	9	Membrane	NA	Acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.	NA	Belongs to the membrane-bound acyltransferase family.	Lipid metabolism; phospholipid metabolism.;Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Acyl chain remodelling of PS;Acyl chain remodelling of PE	PE1	6
+NX_Q6ZNE5	Beclin 1-associated autophagy-related key regulator	492	55309	6.59	0	Autophagosome membrane;Cytoplasm;Preautophagosomal structure membrane;Endoplasmic reticulum membrane	NA	Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).	NA	Belongs to the ATG14 family.	Macroautophagy	PE1	14
+NX_Q6ZNE9	RUN and FYVE domain-containing protein 4	571	64350	6.44	0	Autophagosome	NA	Positively regulates macroautophagy in primary dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger.	NA	NA	NA	PE1	2
+NX_Q6ZNF0	Acid phosphatase type 7	438	50480	9.3	0	Secreted	NA	NA	NA	Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.	NA	PE1	19
+NX_Q6ZNG0	Zinc finger protein 620	422	48503	8.64	0	Centrosome;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	3
+NX_Q6ZNG1	Zinc finger protein 600	722	83124	9.4	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q6ZNG2	Homeobox protein DBX2	339	36555	9.47	0	Nucleus	NA	NA	NA	Belongs to the H2.0 homeobox family.	NA	PE2	12
+NX_Q6ZNG9	KRAB-A domain-containing protein 2	492	56205	5.67	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	17
+NX_Q6ZNH5	Zinc finger protein 497	498	54721	9.27	0	Nucleoplasm;Cell junction;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q6ZNI0	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7	430	49319	8.93	1	Golgi apparatus membrane	NA	Glycosyltransferase.	NA	Belongs to the glycosyltransferase 14 family.	Protein modification; protein glycosylation.;O-linked glycosylation of mucins	PE2	20
+NX_Q6ZNJ1	Neurobeachin-like protein 2	2754	302517	5.95	0	Endoplasmic reticulum	Gray platelet syndrome	Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis.	NA	Belongs to the WD repeat neurobeachin family.	Neutrophil degranulation	PE1	3
+NX_Q6ZNK6	TRAF-interacting protein with FHA domain-containing protein B	161	17888	6.96	0	NA	NA	Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.	NA	NA	NA	PE1	5
+NX_Q6ZNL6	FYVE, RhoGEF and PH domain-containing protein 5	1462	159891	4.93	0	Golgi apparatus;Cell membrane;Early endosome;Endoplasmic reticulum;Ruffle membrane;Cytoskeleton	NA	Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.	NA	NA	NA	PE1	3
+NX_Q6ZNM6	Testis-expressed protein 43	134	15452	9.3	0	NA	NA	NA	NA	NA	NA	PE1	5
+NX_Q6ZNQ3	Leucine-rich repeat-containing protein 69	347	39592	8.89	0	Cell membrane	NA	NA	NA	Belongs to the LRRC69 family.	NA	PE1	8
+NX_Q6ZNR0	Transmembrane protein 91	172	18162	4.96	2	Membrane	NA	NA	NA	Belongs to the CD225/Dispanin family.	NA	PE2	19
+NX_Q6ZNW5	GDP-D-glucose phosphorylase 1	385	42362	6.01	0	Cytoplasm;Cytosol	NA	Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.	NA	Belongs to the GDPGP1 family.	NA	PE1	15
+NX_Q6ZNX1	Shieldin complex subunit 3	250	28842	9.18	0	Nucleoplasm;Nucleolus;Chromosome	NA	Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.	NA	NA	NA	PE1	5
+NX_Q6ZP01	RNA-binding protein 44	1052	118116	5.48	0	Cytoplasm	NA	Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity).	NA	NA	NA	PE1	2
+NX_Q6ZP29	Lysosomal amino acid transporter 1 homolog	291	31947	8.23	7	Cytoplasmic vesicle;Lysosome membrane	NA	Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.	NA	Belongs to the laat-1 family.	Miscellaneous transport and binding events	PE1	1
+NX_Q6ZP65	BICD family-like cargo adapter 1	573	64841	4.93	0	Nucleoplasm;Cytosol;Centrosome;Cytoplasmic vesicle	NA	Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity).	NA	Belongs to the BICDR family.	NA	PE1	12
+NX_Q6ZP68	Putative protein ATP11AUN	121	13416	8.66	0	NA	NA	NA	NA	NA	NA	PE2	13
+NX_Q6ZP80	Transmembrane protein 182	229	25879	6.42	3	Membrane;Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	Belongs to the TMEM182 family.	NA	PE1	2
+NX_Q6ZP82	Coiled-coil domain-containing protein 141	1450	166261	5.41	0	Cytoplasm;Nucleoplasm;Centrosome	NA	Plays a critical role in radial migration and centrosomal function.	NA	NA	NA	PE1	2
+NX_Q6ZP98	Putative uncharacterized protein C16orf47	133	14599	10.17	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_Q6ZPA2	Putative uncharacterized protein FLJ26174	131	13472	6.7	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_Q6ZPB5	Stress-responsive DNAJB4-interacting membrane protein 1	146	16112	8.99	2	Membrane	NA	Promotes neuronal cells survival to stress conditions.	NA	NA	NA	PE1	6
+NX_Q6ZPD8	Diacylglycerol O-acyltransferase 2-like protein 6	337	38593	9.87	2	Endoplasmic reticulum membrane	NA	Diglyceride acyltransferase that uses fatty acyl-CoA as substrate (PubMed:15671038). Particularly active with oleate as a substrate (PubMed:15671038). Has no wax synthase activity to produce wax esters (PubMed:15671038).	NA	Belongs to the diacylglycerol acyltransferase family.	Acyl chain remodeling of DAG and TAG	PE1	X
+NX_Q6ZPD9	Probable C-mannosyltransferase DPY19L3	716	83197	8.94	12	Membrane;Cytoskeleton	NA	Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.	NA	Belongs to the dpy-19 family.	NA	PE1	19
+NX_Q6ZQN5	Forkhead box protein I2	318	32979	8.93	0	Nucleus	NA	Possible transcriptional activator.	NA	NA	NA	PE2	10
+NX_Q6ZQN7	Solute carrier organic anion transporter family member 4C1	724	78948	7.67	12	Nucleoplasm;Cytosol;Basolateral cell membrane;Cell membrane	NA	Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.	NA	Belongs to the organo anion transporter (TC 2.A.60) family.	Transport of organic anions;Neutrophil degranulation	PE1	5
+NX_Q6ZQQ2	Spermatogenesis-associated protein 31D1	1576	175618	9.07	1	Membrane	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA31 family.	NA	PE1	9
+NX_Q6ZQQ6	WD repeat-containing protein 87	2873	333185	6.94	0	NA	NA	NA	NA	NA	NA	PE1	19
+NX_Q6ZQR2	Cilia- and flagella-associated protein 77	320	36499	10.26	0	Cytosol;Cilium	NA	NA	NA	Belongs to the CFAP77 family.	NA	PE1	9
+NX_Q6ZQT0	Putative uncharacterized protein FLJ45035	140	15498	7.4	0	NA	NA	NA	NA	NA	NA	PE5	4
+NX_Q6ZQT7	Putative uncharacterized protein FLJ44672	251	25248	10.23	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_Q6ZQV5	Putative KRAB domain-containing protein ZNF788	82	9552	4.56	0	Nucleus	NA	NA	NA	NA	NA	PE5	19
+NX_Q6ZQW0	Indoleamine 2,3-dioxygenase 2	420	47075	6.39	0	NA	NA	Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885).	NA	Belongs to the indoleamine 2,3-dioxygenase family.	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.;Tryptophan metabolism;Metabolic pathways;African trypanosomiasis;Tryptophan catabolism	PE1	8
+NX_Q6ZQX7	Protein LIAT1	453	49656	7.79	0	Cytosol;Nucleolus	NA	May be involved in ATE1-mediated N-terminal arginylation.	NA	NA	NA	PE1	17
+NX_Q6ZQY2	Leucine-rich repeat-containing protein 74B	392	41621	5.01	0	NA	NA	NA	NA	NA	NA	PE1	22
+NX_Q6ZQY3	Acidic amino acid decarboxylase GADL1	521	59246	5.98	0	Cytosol;Cell membrane	NA	May catalyze the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate.	NA	Belongs to the group II decarboxylase family.	Degradation of cysteine and homocysteine;Aspartate and asparagine metabolism	PE1	3
+NX_Q6ZQY7	Putative uncharacterized protein FLJ46792	126	14345	9.3	0	NA	NA	NA	NA	NA	NA	PE2	15
+NX_Q6ZR03	Uncharacterized protein FLJ46757	302	31336	7.13	0	NA	NA	NA	NA	NA	NA	PE2	21
+NX_Q6ZR08	Dynein heavy chain 12, axonemal	3092	356942	5.85	0	Cilium axoneme	NA	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).	NA	Belongs to the dynein heavy chain family.	NA	PE1	3
+NX_Q6ZR37	Pleckstrin homology domain-containing family G member 7	379	44301	8.55	0	NA	NA	NA	NA	NA	NA	PE2	12
+NX_Q6ZR52	Zinc finger protein 493	646	75342	9.44	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	Generic Transcription Pathway	PE2	19
+NX_Q6ZR54	Putative uncharacterized protein FLJ46641	194	19406	10.93	0	NA	NA	NA	NA	NA	NA	PE5	22
+NX_Q6ZR62	Retrotransposon Gag-like protein 4	310	34685	5.5	0	Nucleoplasm;Cytosol;Cell membrane	NA	Involved in cognitive function in the brain, possibly via the noradrenergic system.	NA	NA	NA	PE2	X
+NX_Q6ZR85	Uncharacterized protein C17orf107	190	19931	6.91	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	17
+NX_Q6ZRC1	Uncharacterized protein C4orf50	276	30622	5.57	0	NA	NA	NA	NA	NA	NA	PE2	4
+NX_Q6ZRF7	Putative zinc finger protein 818	136	15513	10.24	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE5	19
+NX_Q6ZRF8	RING finger protein 207	634	70861	6.21	0	Cytoplasm;Cytosol	NA	Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner.	NA	NA	NA	PE1	1
+NX_Q6ZRG5	Putative uncharacterized protein FLJ43944	221	24122	4.39	0	NA	NA	NA	NA	NA	NA	PE5	17
+NX_Q6ZRH7	Cation channel sperm-associated protein subunit gamma	1159	133032	5.95	1	Membrane;Nucleoplasm;Cytosol;Nucleolus	NA	Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.	NA	Belongs to the CATSPERG family.	Sperm Motility And Taxes	PE1	19
+NX_Q6ZRI0	Otogelin	2925	314794	5.57	0	Apical cell membrane;Extracellular space	Deafness, autosomal recessive, 18B	Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity).	N-glycosylated. Not O-glycosylated.	Belongs to the otogelin family.	NA	PE1	11
+NX_Q6ZRI6	Uncharacterized protein C15orf39	1047	110673	7.72	0	Cytosol	NA	NA	NA	NA	NA	PE1	15
+NX_Q6ZRI8	Rho GTPase-activating protein 36	547	61664	9.48	0	Nucleoplasm;Cell membrane;Cytoplasmic vesicle	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	NA	NA	Rho GTPase cycle	PE1	X
+NX_Q6ZRK6	Coiled-coil domain-containing protein 73	1079	124154	5.42	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_Q6ZRM9	Putative uncharacterized protein FLJ46235	215	21770	9.15	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_Q6ZRN7	Putative uncharacterized protein FLJ46214	208	21161	11.78	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_Q6ZRP0	Proline-rich protein 23C	262	27805	4.48	0	NA	NA	NA	NA	Belongs to the PRR23 family.	NA	PE2	3
+NX_Q6ZRP5	Putative uncharacterized protein FLJ46204	223	25262	11.34	0	NA	NA	NA	NA	NA	NA	PE5	4
+NX_Q6ZRP7	Sulfhydryl oxidase 2	698	77529	7.64	1	Golgi apparatus;Cell membrane;Secreted;Nucleus membrane;Membrane;Nucleoplasm	NA	Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.	NA	Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.	NA	PE1	9
+NX_Q6ZRQ5	Protein MMS22-like	1243	142321	6.72	0	Nucleoplasm;Nucleus	NA	Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.	NA	Belongs to the MMS22 family. MMS22L subfamily.	NA	PE1	6
+NX_Q6ZRR5	TLC domain-containing protein 5	245	27859	8.83	6	Membrane;Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the TLCD5 family.	NA	PE2	11
+NX_Q6ZRR7	Leucine-rich repeat-containing protein 9	1453	166911	7.66	0	NA	NA	NA	NA	NA	NA	PE2	14
+NX_Q6ZRS2	Helicase SRCAP	3230	343555	5.69	0	Cytoplasm;Nucleoplasm;Nucleus	Floating-Harbor syndrome	Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.	NA	Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.	NA	PE1	16
+NX_Q6ZRS4	Protein ITPRID1	1044	115403	5.18	0	Nucleoplasm	NA	NA	NA	NA	NA	PE2	7
+NX_Q6ZRT6	Proline-rich protein 23B	265	28269	4.65	0	NA	NA	NA	NA	Belongs to the PRR23 family.	NA	PE2	3
+NX_Q6ZRU5	Putative uncharacterized protein FLJ46089	148	16879	9.72	0	Secreted	NA	NA	NA	NA	NA	PE5	17
+NX_Q6ZRV2	Protein FAM83H	1179	127122	6.52	0	Cytosol;Cytoskeleton	Amelogenesis imperfecta 3A	May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688).	NA	Belongs to the FAM83 family.	NA	PE1	8
+NX_Q6ZRV3	Putative uncharacterized protein encoded by LINC00696	163	16900	4.89	0	NA	NA	NA	NA	NA	NA	PE5	3
+NX_Q6ZRX8	Putative uncharacterized protein FLJ45999	168	18969	10.14	0	NA	NA	NA	NA	NA	NA	PE5	12
+NX_Q6ZRY4	RNA-binding protein with multiple splicing 2	209	22497	8.63	0	Cytoplasm	NA	Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation.	NA	NA	NA	PE1	15
+NX_Q6ZRZ4	Uncharacterized protein C9orf47	202	22306	10.08	0	Secreted	NA	NA	NA	NA	NA	PE2	9
+NX_Q6ZS02	Putative GED domain-containing protein DNM1P46	220	23740	8.42	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_Q6ZS10	C-type lectin domain family 17, member A	378	42935	4.6	1	Membrane	NA	Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.	Phosphorylated on tyrosine residues.	NA	NA	PE1	19
+NX_Q6ZS11	Ras and Rab interactor-like protein	566	62466	5.59	0	Ruffle;Cytoplasmic vesicle;Nucleoplasm	NA	Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity).	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	19
+NX_Q6ZS17	Rho family-interacting cell polarization regulator 1	1223	132308	5.87	0	Golgi apparatus;Cytoplasm;Cytosol	NA	Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006).	NA	Belongs to the RIPOR family.	NA	PE1	16
+NX_Q6ZS27	Zinc finger protein 662	426	48496	7.76	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	3
+NX_Q6ZS30	Neurobeachin-like protein 1	2694	307237	6.01	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the WD repeat neurobeachin family.	NA	PE1	2
+NX_Q6ZS46	Putative uncharacterized protein FLJ45840	218	22150	10.58	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_Q6ZS49	Putative uncharacterized protein FLJ45831	121	13061	9.78	0	NA	NA	NA	NA	NA	NA	PE5	17
+NX_Q6ZS52	Putative uncharacterized protein FLJ45825	159	17352	10.74	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_Q6ZS62	Colorectal cancer-associated protein 1	124	13401	4.47	1	Membrane	NA	NA	NA	NA	NA	PE2	11
+NX_Q6ZS72	Uncharacterized protein PEAK3	473	50509	8.86	0	NA	NA	NA	NA	NA	NA	PE1	19
+NX_Q6ZS81	WD repeat- and FYVE domain-containing protein 4	3184	353610	5.9	0	Endoplasmic reticulum;Nucleoplasm;Early endosome;Cytosol	NA	Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Plays also a role in B-cell survival through regulation of autophagy.	NA	NA	NA	PE1	10
+NX_Q6ZS82	Regulator of G-protein signaling 9-binding protein	235	25148	6.84	1	Membrane;Cell membrane	Prolonged electroretinal response suppression	Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity).	NA	Belongs to the RGS7BP/RGS9BP family.	Inactivation, recovery and regulation of the phototransduction cascade	PE1	19
+NX_Q6ZS86	Putative glycerol kinase 5	529	59156	6.48	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the FGGY kinase family.	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.	PE1	3
+NX_Q6ZS92	Putative uncharacterized protein FLJ45721	163	18106	9.99	0	NA	NA	NA	NA	NA	NA	PE5	4
+NX_Q6ZS94	Putative uncharacterized protein C1orf229	237	24356	11.59	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q6ZSA7	Leucine-rich repeat-containing protein 55	298	33009	5.55	1	Cell membrane	NA	Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium.	NA	NA	NA	PE1	11
+NX_Q6ZSA8	Putative uncharacterized protein FLJ45684	131	13825	11.82	0	NA	NA	NA	NA	NA	NA	PE5	19
+NX_Q6ZSB3	Putative uncharacterized protein encoded by LINC00299	139	15654	7.82	0	NA	NA	NA	NA	NA	NA	PE5	2
+NX_Q6ZSB9	Zinc finger and BTB domain-containing protein 49	765	85061	6.52	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.;Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.;Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	4
+NX_Q6ZSC3	RNA-binding protein 43	357	40666	9.67	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	2
+NX_Q6ZSG1	E3 ubiquitin-protein ligase RNF165	346	39526	8.19	0	Nucleoplasm;Nucleus;Cell membrane	NA	E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL.	NA	Belongs to the Arkadia family.	NA	PE1	18
+NX_Q6ZSG2	Inhibitory synaptic factor 2A	479	52909	8.23	0	Postsynaptic density	NA	Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.	NA	Belongs to the INSYN2 family.	NA	PE1	10
+NX_Q6ZSI9	Calpain-12	719	81037	5.95	0	Nucleoplasm;Focal adhesion	NA	Calcium-regulated non-lysosomal thiol-protease.	NA	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	19
+NX_Q6ZSJ8	Uncharacterized protein C1orf122	110	11471	6.29	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q6ZSJ9	Protein shisa-6	500	55764	9.44	1	Membrane;Postsynaptic density	NA	Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway.	NA	Belongs to the shisa family.	NA	PE1	17
+NX_Q6ZSK4	Putative uncharacterized protein NTM-AS1	140	15188	9.61	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q6ZSM3	Monocarboxylate transporter 12	516	56498	8.64	12	Mitochondrion;Cell membrane	Cataract 47	Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane.	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	NA	PE1	10
+NX_Q6ZSN1	Putative uncharacterized protein FLJ45355	163	16659	11.74	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q6ZSR3	Putative uncharacterized protein FLJ45275, mitochondrial	168	17863	8.77	0	Mitochondrion	NA	NA	NA	NA	NA	PE5	15
+NX_Q6ZSR6	Putative uncharacterized protein FLJ45256	202	22955	6.09	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_Q6ZSR9	Uncharacterized protein FLJ45252	355	37976	5.14	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q6ZSS3	Zinc finger protein 621	439	49205	9.16	0	Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	3
+NX_Q6ZSS7	Major facilitator superfamily domain-containing protein 6	791	88088	5.35	12	Membrane;Nucleoplasm;Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the major facilitator superfamily. MFSD6 family.	NA	PE1	2
+NX_Q6ZST2	Zinc finger CCHC domain-containing protein 23	131	14410	9.53	0	NA	NA	NA	NA	NA	NA	PE2	4
+NX_Q6ZST4	Lipocalin-like 1 protein	164	17784	8.42	0	NA	NA	NA	NA	Belongs to the calycin superfamily. Lipocalin family.	NA	PE2	9
+NX_Q6ZSU1	Putative inactive cytochrome P450 2G1	146	16683	6.27	0	NA	NA	NA	NA	Belongs to the cytochrome P450 family.	NA	PE5	19
+NX_Q6ZSV7	Putative uncharacterized protein FLJ45177	163	16907	8.74	0	NA	NA	NA	NA	NA	NA	PE2	6
+NX_Q6ZSY5	Protein phosphatase 1 regulatory subunit 3F	799	82798	4.5	1	Membrane;Cytoplasmic vesicle;Nucleoplasm	NA	Glycogen-targeting subunit for protein phosphatase 1 (PP1).	NA	NA	NA	PE1	X
+NX_Q6ZSZ5	Rho guanine nucleotide exchange factor 18	1361	151642	5.98	0	Cytoplasm;Cell membrane;Apical cell membrane;Cytosol;Cytoskeleton	Retinitis pigmentosa 78	Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950).	NA	NA	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	19
+NX_Q6ZSZ6	Teashirt homolog 1	1077	117916	6.62	0	Nucleoplasm;Nucleus	Aural atresia, congenital	Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).	NA	Belongs to the teashirt C2H2-type zinc-finger protein family.	NA	PE1	18
+NX_Q6ZT07	TBC1 domain family member 9	1266	143229	5.18	0	Nucleoplasm;Cytosol	NA	May act as a GTPase-activating protein for Rab family protein(s).	NA	NA	NA	PE1	4
+NX_Q6ZT12	E3 ubiquitin-protein ligase UBR3	1888	212433	5.74	3	Membrane;Nucleoplasm;Nucleolus	NA	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610).	NA	Belongs to the UBR1 family.	Protein modification; protein ubiquitination.	PE1	2
+NX_Q6ZT21	Transmembrane protein with metallophosphoesterase domain	453	49453	6.43	5	Membrane;Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the metallophosphoesterase superfamily. LOC643853 family.	NA	PE1	3
+NX_Q6ZT52	Protein FAM43B	329	36776	10.36	0	Cytosol	NA	NA	NA	Belongs to the FAM43 family.	NA	PE1	1
+NX_Q6ZT62	Bargin	677	73599	5.13	0	Cytosol;Cell membrane	NA	GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains.	NA	NA	NA	PE1	22
+NX_Q6ZT77	Putative zinc finger protein 826	177	20580	10.14	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE5	19
+NX_Q6ZT89	Solute carrier family 25 member 48	311	33440	8.95	6	Mitochondrion inner membrane;Cytoskeleton	NA	NA	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	5
+NX_Q6ZT98	Tubulin polyglutamylase TTLL7	887	102999	9.36	0	Perikaryon;Dendrite;Cilium;Cilium basal body	NA	Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:25959773). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity).	NA	Belongs to the tubulin--tyrosine ligase family.	Carboxyterminal post-translational modifications of tubulin	PE1	1
+NX_Q6ZTA4	Tripartite motif-containing protein 67	783	83823	7.08	0	Cytoplasm;Cytoskeleton	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE1	1
+NX_Q6ZTB9	Putative zinc finger protein 833	187	21749	8.93	0	NA	NA	NA	NA	NA	NA	PE5	19
+NX_Q6ZTC4	Putative uncharacterized protein FLJ44790	211	22100	10.68	0	NA	NA	NA	NA	NA	NA	PE2	20
+NX_Q6ZTI0	Putative uncharacterized protein FLJ44636	123	12888	10	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q6ZTI6	Refilin-A	216	23610	8.75	0	Golgi apparatus;Nucleoplasm;Cytoskeleton	NA	Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells.	NA	Belongs to the Refilin family.	NA	PE1	12
+NX_Q6ZTK2	Putative uncharacterized protein LOC400499	550	61934	9.07	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_Q6ZTN6	Ankyrin repeat domain-containing protein 13D	518	58476	5.26	0	Nucleoplasm;Mitochondrion;Late endosome;Cell membrane	NA	Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	NA	NA	NA	PE1	11
+NX_Q6ZTQ3	Ras association domain-containing protein 6	369	43384	8.79	0	Golgi apparatus;Nucleoplasm	NA	Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).	NA	NA	NA	PE1	4
+NX_Q6ZTQ4	Cadherin-related family member 3	885	97977	5.26	1	Nucleolus;Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.;(Microbial infection) Acts as a receptor for rhinovirus C.	NA	NA	NA	PE1	7
+NX_Q6ZTR5	Cilia- and flagella-associated protein 47	3187	361625	7.55	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_Q6ZTR6	Putative uncharacterized protein C18orf65	163	17236	10.37	0	NA	NA	NA	NA	NA	NA	PE2	18
+NX_Q6ZTR7	Protein FAM92B	304	34755	8.84	0	Cilium basal body;Centriole	NA	May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616).	NA	Belongs to the FAM92 family.	NA	PE1	16
+NX_Q6ZTU2	Putative EP400-like protein	488	51753	6.76	0	NA	NA	NA	NA	NA	NA	PE5	12
+NX_Q6ZTW0	Tubulin polyglutamylase complex subunit 1	290	31275	9.26	0	Flagellum axoneme;Cilium basal body;Centrosome;Cilium axoneme;Flagellum basal body;Axon;Dendrite	NA	May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).	NA	NA	Carboxyterminal post-translational modifications of tubulin	PE1	19
+NX_Q6ZTY9	Uncharacterized protein C7orf65	151	16773	9.48	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_Q6ZTZ1	Myb/SANT-like DNA-binding domain-containing protein 1	278	31632	8.99	0	NA	NA	NA	NA	NA	NA	PE2	4
+NX_Q6ZU15	Septin-14	432	50025	5.87	0	Cytoplasm;Cytoskeleton	NA	Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	NA	PE1	7
+NX_Q6ZU35	Cancer-related regulator of actin dynamics	1233	136760	5.5	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin.	NA	NA	NA	PE1	4
+NX_Q6ZU45	Putative C-type lectin domain family 20 member A	400	44255	6.37	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q6ZU52	Uncharacterized protein KIAA0408	694	79163	8.64	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	6
+NX_Q6ZU64	Cilia- and flagella-associated protein 65	1925	217250	6.07	1	Flagellum membrane	NA	May play a role in sperm motility.	NA	Belongs to the CFAP65 family.	NA	PE1	2
+NX_Q6ZU65	Ubinuclein-2	1347	146089	9.24	0	Nucleoplasm	NA	NA	NA	Belongs to the ubinuclein family.	NA	PE1	7
+NX_Q6ZU67	BEN domain-containing protein 4	534	58375	5.75	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	4
+NX_Q6ZU69	Protein FAM205A	1335	148096	8.62	1	Membrane	NA	NA	NA	Belongs to the FAM205 family.	NA	PE1	9
+NX_Q6ZU80	Centrosomal protein of 128 kDa	1094	128015	6.11	0	Centriole;Centriolar satellite;Spindle pole;Centrosome;Cytosol	NA	NA	NA	NA	NA	PE1	14
+NX_Q6ZUA9	Maestro heat-like repeat family member 5	1318	149091	7.63	0	NA	NA	NA	NA	NA	NA	PE2	8
+NX_Q6ZUB0	Spermatogenesis-associated protein 31D4	917	102306	8.2	1	Membrane	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA31 family.	NA	PE1	9
+NX_Q6ZUB1	Spermatogenesis-associated protein 31E1	1445	157136	9.29	1	Membrane	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA31 family.	NA	PE1	9
+NX_Q6ZUF6	Putative uncharacterized protein encoded by LINC00336	198	20903	11.57	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_Q6ZUG5	Uncharacterized protein FLJ43738	572	66039	6.81	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_Q6ZUI0	Tumor protein p63-regulated gene 1 protein	275	31230	6.61	0	Cytoplasm;Nucleoplasm	NA	NA	NA	Belongs to the TPRG1 family.	NA	PE1	3
+NX_Q6ZUJ4	Uncharacterized protein C3orf62	267	30194	5.36	0	Nucleus speckle	NA	NA	NA	NA	NA	PE1	3
+NX_Q6ZUJ8	Phosphoinositide 3-kinase adapter protein 1	805	90398	5.25	0	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	NA	Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.	Are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation (By similarity). Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes (By similarity).;Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK (By similarity).	NA	B cell receptor signaling pathway;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	10
+NX_Q6ZUK4	Transmembrane protein 26	368	41672	6.4	8	Membrane	NA	NA	NA	NA	NA	PE1	10
+NX_Q6ZUL3	Uncharacterized protein C8orf86	223	24736	9.59	0	NA	NA	NA	NA	NA	NA	PE2	8
+NX_Q6ZUM4	Rho GTPase-activating protein 27	889	98396	5.4	0	Membrane;Nucleoplasm;Cytoplasm	NA	Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).	NA	NA	Rho GTPase cycle	PE1	17
+NX_Q6ZUS5	Coiled-coil domain-containing protein 121	278	33061	9.84	0	Cytosol;Cytoskeleton	NA	NA	NA	NA	NA	PE1	2
+NX_Q6ZUS6	Coiled-coil domain-containing protein 149	474	52796	5.92	0	Nucleolus	NA	NA	NA	Belongs to the CCDC149 family.	NA	PE1	4
+NX_Q6ZUT1	Uncharacterized protein NKAPD1	292	34110	9.73	0	Cytosol	NA	NA	NA	NA	NA	PE1	11
+NX_Q6ZUT3	FERM domain-containing protein 7	714	81614	8.05	0	Neuron projection;Growth cone	Nystagmus congenital X-linked 1	Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability.	NA	NA	NA	PE1	X
+NX_Q6ZUT4	Putative uncharacterized protein FLJ43343	128	14221	9.39	0	NA	NA	NA	NA	NA	NA	PE5	12
+NX_Q6ZUT6	Coiled-coil domain-containing protein 9B	534	57325	9.31	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	15
+NX_Q6ZUT9	DENN domain-containing protein 5B	1274	145020	6.29	1	Membrane;Nucleolus;Cytoskeleton	NA	Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.	NA	Belongs to the RAB6IP1 family.	RAB GEFs exchange GTP for GDP on RABs	PE1	12
+NX_Q6ZUU3	FOXL2 neighbor protein	175	18625	11.34	0	Nucleolus	NA	NA	NA	NA	NA	PE2	3
+NX_Q6ZUV0	Putative cytosolic acyl coenzyme A thioester hydrolase-like	252	28164	6.71	0	Cytoplasm	NA	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH.	NA	NA	Mitochondrial Fatty Acid Beta-Oxidation	PE5	4
+NX_Q6ZUX3	TOG array regulator of axonemal microtubules protein 2	1019	111153	9.51	0	NA	NA	NA	NA	Belongs to the Crescerin family.	NA	PE1	2
+NX_Q6ZUX7	LHFPL tetraspan subfamily member 2 protein	228	24486	6.06	4	Membrane;Cytoplasmic vesicle;Cytoskeleton	NA	Plays a role in female and male fertility. Involved in distal reproductive tract development.	NA	Belongs to the LHFP family.	Platelet degranulation	PE1	5
+NX_Q6ZV29	Patatin-like phospholipase domain-containing protein 7	1317	145705	7.77	1	Microsome membrane;Lysosome membrane;Centriolar satellite;Nucleus membrane;Membrane;Mitochondrion membrane;Cytosol	NA	Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.	NA	Belongs to the NTE family.	Glycerophospholipid metabolism;Glycerophospholipid catabolism	PE1	9
+NX_Q6ZV50	DNA-binding protein RFX8	586	66266	5.75	0	Nucleoplasm;Nucleus	NA	May be a transcription factor.	NA	Belongs to the RFX family.	NA	PE2	2
+NX_Q6ZV56	Putative uncharacterized protein C22orf34	151	16313	6.5	0	NA	NA	NA	NA	NA	NA	PE5	22
+NX_Q6ZV60	Putative uncharacterized protein encoded by LINC00173	143	16386	9.92	0	NA	NA	NA	NA	NA	NA	PE5	12
+NX_Q6ZV65	Protein FAM47E	393	45662	9.47	0	Cytosol;Cell membrane	NA	NA	NA	Belongs to the FAM47 family.	NA	PE2	4
+NX_Q6ZV70	LanC-like protein 3	420	46319	6.71	0	Mitochondrion	NA	NA	NA	Belongs to the LanC-like protein family.	NA	PE1	X
+NX_Q6ZV73	FYVE, RhoGEF and PH domain-containing protein 6	1430	160816	6.61	0	Cytoplasmic vesicle;Cytoplasm;Cytoskeleton	NA	May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).	NA	NA	NA	PE1	12
+NX_Q6ZV77	Uncharacterized protein C9orf139	190	20001	6.99	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q6ZV80	Uncharacterized protein C2orf91	131	14825	9.55	0	NA	NA	NA	NA	NA	NA	PE2	2
+NX_Q6ZV89	SH2 domain-containing protein 5	423	46797	8.89	0	Cytosol;Postsynaptic density	NA	May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.	NA	NA	NA	PE1	1
+NX_Q6ZVC0	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1	841	87928	9.72	0	Golgi apparatus;Cytoplasmic vesicle	NA	Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.	Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.	Belongs to the NYAP family.	NA	PE1	7
+NX_Q6ZVD7	Storkhead-box protein 1	989	110962	7.82	0	Cytoplasm;Nucleolus;Nucleoplasm;Centrosome;Cytosol;Nucleus	Pre-eclampsia/eclampsia 4	Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177).;Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity).	NA	NA	NA	PE1	10
+NX_Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	1323	146751	5.45	0	Membrane;Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606).	NA	NA	Negative regulation of the PI3K/AKT network	PE1	16
+NX_Q6ZVE7	Vesicle transport protein GOT1A	132	14887	10.38	4	Golgi apparatus membrane	NA	May be involved in fusion of ER-derived transport vesicles with the Golgi complex.	NA	Belongs to the GOT1 family.	NA	PE1	1
+NX_Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	776	82439	7.52	0	Nucleoplasm;Nucleolus	NA	May be involved in neurite outgrowth.	NA	NA	NA	PE1	4
+NX_Q6ZVH6	Putative uncharacterized protein FLJ42569	145	15831	8.23	0	NA	NA	NA	NA	NA	NA	PE2	11
+NX_Q6ZVH7	Espin-like protein	1005	108132	6.01	0	Stereocilium	NA	Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing.	NA	NA	NA	PE1	2
+NX_Q6ZVK1	Transmembrane protein 179	233	26378	5.07	4	Membrane;Mitochondrion	NA	NA	NA	Belongs to the TMEM179 family.	NA	PE1	14
+NX_Q6ZVK8	8-oxo-dGDP phosphatase NUDT18	323	35501	5.83	0	Golgi apparatus;Nucleoplasm	NA	Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.	NA	Belongs to the Nudix hydrolase family.	Phosphate bond hydrolysis by NUDT proteins	PE1	8
+NX_Q6ZVL6	UPF0606 protein KIAA1549L	1849	198999	8.32	1	Membrane;Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	Belongs to the UPF0606 family.	NA	PE1	11
+NX_Q6ZVL8	Putative uncharacterized protein FLJ42384	140	15891	9.03	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_Q6ZVM7	TOM1-like protein 2	507	55556	4.69	0	Golgi apparatus;Cytoskeleton	NA	Probable role in protein transport. May regulate growth factor-induced mitogenic signaling.	NA	Belongs to the TOM1 family.	NA	PE1	17
+NX_Q6ZVN7	Putative protein SEM1, isoform 2	128	14085	9.69	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_Q6ZVN8	Hemojuvelin	426	45080	7.57	0	Cell membrane	Hemochromatosis 2A	Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.	Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space; regulates HJV activity in BMP signaling and thefore iron homeostasis.	Belongs to the repulsive guidance molecule (RGM) family.	Netrin-1 signaling	PE1	1
+NX_Q6ZVQ6	Putative uncharacterized protein FLJ42213	151	17006	11.05	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_Q6ZVS7	Protein FAM183BP	135	16193	8.06	0	Cilium basal body	NA	NA	NA	Belongs to the FAM183 family.	NA	PE5	7
+NX_Q6ZVT0	Inactive polyglycylase TTLL10	673	75042	9.36	0	NA	NA	Inactive polyglycylase.	NA	NA	Carboxyterminal post-translational modifications of tubulin	PE1	1
+NX_Q6ZVT6	Uncharacterized protein C3orf67	689	76271	5.09	0	Golgi apparatus	NA	NA	NA	NA	NA	PE2	3
+NX_Q6ZVU0	Putative uncharacterized protein FLJ42102	165	18168	9.05	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q6ZVW7	Putative interleukin-17 receptor E-like	336	37514	8.74	0	NA	NA	NA	NA	NA	NA	PE1	22
+NX_Q6ZVX7	F-box only protein 50	275	30847	6.16	0	Cytoplasm	NA	Promotes cell proliferation.	NA	NA	NA	PE1	19
+NX_Q6ZVX9	Membrane progestin receptor epsilon	377	42692	8.92	7	Cell membrane	NA	Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).	NA	Belongs to the ADIPOR family.	NA	PE1	3
+NX_Q6ZVZ8	Ankyrin repeat and SOCS box protein 18	466	50803	6.49	0	NA	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE2	2
+NX_Q6ZW05	Patched domain-containing protein 4	846	96371	8.84	12	Membrane;Cytosol;Cell membrane	NA	Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells.	NA	Belongs to the patched family.	NA	PE1	6
+NX_Q6ZW13	Uncharacterized protein C16orf86	317	33511	5.29	0	NA	NA	NA	NA	NA	NA	PE1	16
+NX_Q6ZW31	Rho GTPase-activating protein SYDE1	735	79793	8.72	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469).	NA	NA	Rho GTPase cycle	PE1	19
+NX_Q6ZW33	MICAL C-terminal-like protein	695	77277	8.64	0	Cytoplasm	NA	May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. May act as Rab effector protein and play a role in vesicle trafficking.	NA	Belongs to the ebitein family.	NA	PE1	11
+NX_Q6ZW49	PAX-interacting protein 1	1069	121341	6.24	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus matrix;Chromosome	NA	Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity).	NA	NA	Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	7
+NX_Q6ZW61	Bardet-Biedl syndrome 12 protein	710	79085	5.8	0	Cilium	Bardet-Biedl syndrome 12	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). Involved in adipogenic differentiation (PubMed:19190184).	NA	Belongs to the TCP-1 chaperonin family. BBS12 subfamily.	BBSome-mediated cargo-targeting to cilium	PE1	4
+NX_Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	656	72038	5.31	0	Cytoplasm;Nucleoplasm;Cilium;Cytosol	NA	May be involved in vasopressin signaling in the kidney.	Hydroxylated at Asn-96, most probably by HIF1AN.;Phosphorylations at Ser-5, Ser-225, Thr-319, Ser-320, Ser-368 and Ser-371 occur in a NEK7-dependent manner.;Polyubiquitinated.	NA	NA	PE1	16
+NX_Q6ZWB6	BTB/POZ domain-containing protein KCTD8	473	52440	8.6	0	Cytoplasmic vesicle;Presynaptic cell membrane;Postsynaptic cell membrane	NA	Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).	NA	NA	NA	PE1	4
+NX_Q6ZWC4	Putative uncharacterized protein LOC100128429	215	22988	9.32	0	NA	NA	NA	NA	NA	NA	PE5	19
+NX_Q6ZWE6	Pleckstrin homology domain-containing family M member 3	761	87166	6.69	0	Golgi apparatus;Cytoplasm;Cell membrane;Cytoplasmic vesicle;Cytosol	NA	Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation.	NA	NA	NA	PE1	2
+NX_Q6ZWH5	Serine/threonine-protein kinase Nek10	1172	133259	6.35	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	NA	PE1	3
+NX_Q6ZWI9	Ret finger protein-like 4B	263	29922	5.52	0	NA	NA	NA	NA	NA	NA	PE1	6
+NX_Q6ZWJ1	Syntaxin-binding protein 4	553	61662	5.12	0	Cytoplasm;Cytosol;Cell membrane	NA	Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).	Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A (By similarity).	NA	NA	PE1	17
+NX_Q6ZWJ8	Kielin/chordin-like protein	1568	166935	5.5	0	Secreted	NA	Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).	NA	NA	NA	PE1	7
+NX_Q6ZWK4	Regulator of hemoglobinization and erythroid cell expansion protein	172	19405	4.76	1	Cell membrane	NA	Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation (PubMed:25092874).	Phosphorylated. Phosphorylation on Tyr-132 and Tyr-141 occurs in a erythropoietin (EPO)-dependent manner (PubMed:25092874).	NA	NA	PE1	1
+NX_Q6ZWK6	Transmembrane protease serine 11F	438	49410	9.33	1	Membrane	NA	Probable serine protease.	NA	Belongs to the peptidase S1 family.	NA	PE2	4
+NX_Q6ZWL3	Cytochrome P450 4V2	525	60724	7.19	1	Endoplasmic reticulum membrane;Nucleus speckle	Bietti crystalline corneoretinal dystrophy	Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism.;The canonical retinoid cycle in rods (twilight vision);Endogenous sterols	PE1	4
+NX_Q6ZWT7	Lysophospholipid acyltransferase 2	520	59527	8.3	9	Membrane;Cytoplasmic vesicle	NA	Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.	NA	Belongs to the membrane-bound acyltransferase family.	Lipid metabolism; phospholipid metabolism.;Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Acyl chain remodelling of PC;Acyl chain remodelling of PE	PE1	2
+NX_Q6ZXV5	Protein O-mannosyl-transferase TMTC3	915	104009	9.03	9	Membrane;Endoplasmic reticulum	Lissencephaly 8	Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3 (PubMed:28973932). Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.	NA	Belongs to the TMTC family.	Protein modification; protein glycosylation.	PE1	12
+NX_Q6ZYL4	General transcription factor IIH subunit 5	71	8053	4.5	0	Nucleus	Trichothiodystrophy 3, photosensitive	Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.	NA	Belongs to the TFB5 family.	Basal transcription factors;Nucleotide excision repair;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Tat-mediated elongation of the HIV-1 transcript;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;TP53 Regulates Transcription of DNA Repair Genes	PE1	6
+NX_Q701N2	Keratin-associated protein 5-5	237	21409	8.39	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 5 family.	Keratinization	PE2	11
+NX_Q701N4	Keratin-associated protein 5-2	177	16271	8.31	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 5 family.	Keratinization	PE1	11
+NX_Q702N8	Xin actin-binding repeat-containing protein 1	1843	198561	5.78	0	Nucleoplasm;Cell junction;Cell membrane;Cytoskeleton	NA	Protects actin filaments from depolymerization.	NA	Belongs to the Xin family.	NA	PE1	3
+NX_Q709C8	Vacuolar protein sorting-associated protein 13C	3753	422390	6.38	0	Mitochondrion outer membrane;Cytoskeleton	Parkinson disease 23, autosomal recessive, early onset	Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization.	NA	Belongs to the VPS13 family.	NA	PE1	15
+NX_Q709F0	Acyl-CoA dehydrogenase family member 11	780	87264	8.23	0	Mitochondrion membrane;Peroxisome	NA	Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA (PubMed:21237683). Probably participates to beta-oxydation and energy production but could also play role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain (Probable).	NA	Belongs to the acyl-CoA dehydrogenase family.	Lipid metabolism; fatty acid beta-oxidation.;Mitochondrial Fatty Acid Beta-Oxidation	PE1	3
+NX_Q70CQ1	Ubiquitin carboxyl-terminal hydrolase 49	688	79198	9.37	0	Nucleus	NA	Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.	NA	Belongs to the peptidase C19 family.	Ub-specific processing proteases	PE1	6
+NX_Q70CQ2	Ubiquitin carboxyl-terminal hydrolase 34	3546	404233	5.51	0	Nucleoplasm;Cytoplasm	NA	Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.	NA	Belongs to the peptidase C19 family.	TCF dependent signaling in response to WNT;Ub-specific processing proteases	PE1	2
+NX_Q70CQ3	Ubiquitin carboxyl-terminal hydrolase 30	517	58503	8.57	1	Mitochondrion outer membrane	NA	Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).	Ubiquitinated by parkin (PRKN) at Lys-235 and Lys-289, leading to its degradation.	Belongs to the peptidase C19 family.	Ub-specific processing proteases	PE1	12
+NX_Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	1352	146651	9.35	0	Cytosol	NA	May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).	NA	Belongs to the peptidase C19 family.	NA	PE1	16
+NX_Q70E73	Ras-associated and pleckstrin homology domains-containing protein 1	1250	135256	8.97	0	Cell membrane;Lamellipodium;Filopodium;Cytosol;Nucleus;Cytoskeleton	NA	Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.	RAPH1 is phosphorylated by ABL2 (Phosphotyrosine:PTM-0255)	Belongs to the MRL family.	NA	PE1	2
+NX_Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	1073	120806	7.54	0	Golgi apparatus;Nucleoplasm;Tight junction	NA	Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245).	NA	Belongs to the peptidase C19 family.	NA	PE1	4
+NX_Q70EK9	Ubiquitin carboxyl-terminal hydrolase 51	711	79756	8.73	0	Cytosol;Nucleolus;Chromosome	NA	Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998).	NA	Belongs to the peptidase C19 family.	NA	PE1	X
+NX_Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54	1684	187388	6.89	0	Mitochondrion	NA	Has no peptidase activity.	NA	Belongs to the peptidase C19 family.	NA	PE1	10
+NX_Q70EL2	Ubiquitin carboxyl-terminal hydrolase 45	814	91733	8.32	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the peptidase C19 family.	Formation of Incision Complex in GG-NER	PE1	6
+NX_Q70EL3	Inactive ubiquitin carboxyl-terminal hydrolase 50	339	38955	6.31	0	NA	NA	Has no peptidase activity.	NA	Belongs to the peptidase C19 family.	NA	PE2	15
+NX_Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	1123	122809	9.35	0	NA	NA	May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).	NA	Belongs to the peptidase C19 family.	Termination of translesion DNA synthesis	PE1	17
+NX_Q70HW3	S-adenosylmethionine mitochondrial carrier protein	274	29354	9.39	6	Mitochondrion inner membrane;Mitochondrion	Combined oxidative phosphorylation deficiency 28	Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Transport of inorganic cations/anions and amino acids/oligopeptides	PE1	3
+NX_Q70IA6	MOB kinase activator 2	237	26927	6.3	0	Nucleolus;Nucleoplasm;Cytosol;Perinuclear region;Nucleus	NA	Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.	Phosphorylated.	Belongs to the MOB1/phocein family.	NA	PE1	11
+NX_Q70IA8	MOB kinase activator 3C	216	25623	9.01	0	NA	NA	May regulate the activity of kinases.	NA	Belongs to the MOB1/phocein family.	NA	PE1	1
+NX_Q70J99	Protein unc-13 homolog D	1090	123282	6.19	0	Cytoplasm;Recycling endosome;Membrane;Late endosome;Lysosome;Cytoplasmic vesicle;Cytosol	Familial hemophagocytic lymphohistiocytosis 3	Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.	NA	Belongs to the unc-13 family.	Neutrophil degranulation	PE1	17
+NX_Q70JA7	Chondroitin sulfate synthase 3	882	100284	8.91	1	Golgi stack membrane	NA	Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1.	NA	Belongs to the chondroitin N-acetylgalactosaminyltransferase family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Metabolic pathways;Chondroitin sulfate biosynthesis	PE1	5
+NX_Q70SY1	Cyclic AMP-responsive element-binding protein 3-like protein 2	520	57415	5.3	1	Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum membrane;Nucleus	NA	Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827).	Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2).;N-glycosylated.;Ubiquitinated by HRD1/SYVN1; undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L2 is stabilized.	Belongs to the bZIP family. ATF subfamily.	Cholinergic synapse;Dopaminergic synapse;Melanogenesis;Vasopressin-regulated water reabsorption;Huntington's disease;Prostate cancer;CREB3 factors activate genes	PE1	7
+NX_Q70UQ0	Inhibitor of nuclear factor kappa-B kinase-interacting protein	350	39309	9.21	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Target of p53/TP53 with pro-apoptotic function.	N-glycosylated.;Is glycosylated at Asn-154.	NA	NA	PE1	12
+NX_Q70YC4	Talanin	216	24036	8.19	0	NA	Uric acid nephrolithiasis	May play a role in uric acid excretion.	NA	NA	NA	PE2	10
+NX_Q70YC5	Protein ZNF365	407	46542	9.3	0	Cytoplasmic vesicle;Centrosome;Centriolar satellite	NA	Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166). Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040).	NA	NA	NA	PE1	10
+NX_Q70Z35	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein	1606	182622	7.26	0	Endoplasmic reticulum	NA	Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.	NA	NA	Regulation of PTEN stability and activity	PE1	8
+NX_Q70Z44	5-hydroxytryptamine receptor 3D	454	50191	9.02	4	Cell membrane	NA	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3D sub-subfamily.	Neurotransmitter receptors and postsynaptic signal transmission	PE1	3
+NX_Q70Z53	Protein FRA10AC1	315	37548	8.25	0	Nucleus	NA	NA	NA	NA	NA	PE1	10
+NX_Q711Q0	Cardiac-enriched FHL2-interacting protein	1435	156477	5.98	0	Nucleoplasm;Z line;Mitochondrion	NA	Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway.	NA	NA	NA	PE1	10
+NX_Q712K3	Ubiquitin-conjugating enzyme E2 R2	238	27166	4.26	0	Nucleoplasm;Nucleolus	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.	NA	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Herpes simplex infection;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	9
+NX_Q717R9	Cystin-1	158	16393	6.76	0	Cilium membrane;Cilium axoneme	NA	NA	NA	NA	Trafficking of myristoylated proteins to the cilium	PE1	2
+NX_Q719H9	BTB/POZ domain-containing protein KCTD1	257	29405	6.61	0	Nucleus	Scalp-ear-nipple syndrome	May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.	Sumoylated.	NA	Negative regulation of activity of TFAP2 (AP-2) family transcription factors	PE1	18
+NX_Q719I0	Putative activator of 90 kDa heat shock protein ATPase homolog 2	299	33806	6.98	0	Cytoplasm;Nucleus	NA	Co-chaperone that stimulates HSP90 ATPase activity.	NA	Belongs to the AHA1 family.	NA	PE5	2
+NX_Q71DI3	Histone H3.2	136	15388	11.27	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes (PubMed:29211711). It gives a specific tag for epigenetic transcription activation (PubMed:29211711).;Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.;Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.;Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac) (PubMed:30257210).;Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.;Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.;Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination. Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.;Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.;Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.	Belongs to the histone H3 family.	Systemic lupus erythematosus;Systemic lupus erythematosus;Systemic lupus erythematosus;Transcriptional regulation by small RNAs;PKMTs methylate histone lysines;RMTs methylate histone arginines;Factors involved in megakaryocyte development and platelet production;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Interleukin-7 signaling;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;HDMs demethylate histones;Chromatin modifying enzymes;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	1
+NX_Q71F23	Centromere protein U	418	47522	9.18	0	Kinetochore;Cytoplasm;Centriolar satellite;Nucleoplasm;Nucleus	NA	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.	Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.	Belongs to the CENP-U/AME1 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	4
+NX_Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	2210	242602	5.67	0	Golgi apparatus;Nucleoplasm;Nucleus	Mental retardation and distinctive facial features with or without cardiac defects;Transposition of the great arteries dextro-looped 1	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.	NA	Belongs to the Mediator complex subunit 13 family.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	12
+NX_Q71F78	Putative lung carcinoma-associated protein 10	164	17306	9.33	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_Q71H61	Immunoglobulin-like domain-containing receptor 2	639	71200	8.43	1	Endoplasmic reticulum membrane;Cell membrane	NA	May be involved in lipid homeostasis and ER stress pathways.	NA	Belongs to the immunoglobulin superfamily. LISCH7 family.	NA	PE1	1
+NX_Q71RC2	La-related protein 4	724	80596	6.2	0	Cytoplasm;Stress granule;Nucleolus;Cytosol;Nucleus	NA	RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).	NA	NA	NA	PE1	12
+NX_Q71RC9	Small integral membrane protein 5	77	8540	8.24	1	Membrane;Cytoplasmic vesicle;Golgi apparatus	NA	NA	NA	NA	NA	PE1	17
+NX_Q71RG4	Transmembrane and ubiquitin-like domain-containing protein 2	321	33788	4.92	3	Membrane;Cytoplasmic vesicle;Cytosol;Endoplasmic reticulum	NA	NA	NA	NA	NA	PE1	17
+NX_Q71RG6	Putative chemokine-related protein FP248	208	21376	9.25	0	Secreted	NA	NA	NA	NA	NA	PE5	8
+NX_Q71RH2	Ceramide synthase	274	30629	9.12	4	Endoplasmic reticulum;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Involved in ceramide synthesis.	NA	NA	NA	PE1	16
+NX_Q71RS6	Sodium/potassium/calcium exchanger 5	500	54888	5.77	11	trans-Golgi network membrane;Melanosome	Albinism, oculocutaneous, 6	Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+).	NA	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.	Sodium/Calcium exchangers;Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)	PE1	15
+NX_Q71SY5	Mediator of RNA polymerase II transcription subunit 25	747	78171	8.61	0	Cytoplasm;Nucleoplasm;Nucleus	Charcot-Marie-Tooth disease 2B2;Basel-Vanagaite-Smirin-Yosef syndrome	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.	NA	Belongs to the Mediator complex subunit 25 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	19
+NX_Q71U36	Tubulin alpha-1A chain	451	50136	4.94	0	Cytoskeleton	Lissencephaly 3	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.;Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution.;Tubulin alpha-1A chain: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1. Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules (PubMed:26972003, PubMed:26968983). In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (PubMed:26968983).;Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Detyrosinated tubulin alpha-1A chain: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;MHC class II antigen presentation;Intraflagellar transport;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;AURKA Activation by TPX2;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	12
+NX_Q71UI9	Histone H2A.V	128	13509	10.58	0	Nucleus;Chromosome	NA	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).	Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.;Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity).	Belongs to the histone H2A family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;RMTs methylate histone arginines;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Pre-NOTCH Transcription and Translation;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	7
+NX_Q71UM5	40S ribosomal protein S27-like	84	9477	9.57	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eS27 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	15
+NX_Q75L30	Putative uncharacterized protein FLJ92257	129	13422	9.14	0	NA	NA	NA	NA	NA	NA	PE5	7
+NX_Q75LS8	Putative FK506-binding protein 9-like protein	142	15591	4.29	0	NA	NA	NA	NA	NA	NA	PE5	7
+NX_Q75MW2	Protein ZNF767	155	17236	9.66	0	NA	NA	NA	NA	NA	Generic Transcription Pathway	PE5	7
+NX_Q75N03	E3 ubiquitin-protein ligase Hakai	491	54519	8.57	0	Cytoplasm;Nucleoplasm;Nucleus speckle	NA	E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755).	Phosphorylated on tyrosine residues.	Belongs to the Hakai family.	Protein modification; protein ubiquitination.;InlA-mediated entry of Listeria monocytogenes into host cells	PE1	7
+NX_Q75N90	Fibrillin-3	2809	300356	4.92	0	Extracellular matrix	NA	Fibrillin-3: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support.	Probably forms intermolecular disulfide bonds either with other FBN3 molecules or with other components of the microfibrils.	Belongs to the fibrillin family.	Degradation of the extracellular matrix;Molecules associated with elastic fibres;Elastic fibre formation	PE1	19
+NX_Q75NE6	Putative microRNA 17 host gene protein	70	8163	9.26	1	Membrane	Feingold syndrome 2	NA	NA	NA	NA	PE5	13
+NX_Q75QN2	Integrator complex subunit 8	995	113088	6.65	0	Nucleoplasm;Nucleus	NA	Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.	NA	Belongs to the Integrator subunit 8 family.	RNA polymerase II transcribes snRNA genes	PE1	8
+NX_Q75T13	GPI inositol-deacylase	922	105383	9.14	7	Endoplasmic reticulum membrane	Mental retardation, autosomal recessive 42	Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity).	NA	Belongs to the GPI inositol-deacylase family.	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Attachment of GPI anchor to uPAR	PE1	2
+NX_Q75V66	Anoctamin-5	913	107188	6.37	8	Endoplasmic reticulum membrane;Cell membrane	Muscular dystrophy, limb-girdle, autosomal recessive 12;Gnathodiaphyseal dysplasia;Miyoshi muscular dystrophy 3	Does not exhibit calcium-activated chloride channel (CaCC) activity.	NA	Belongs to the anoctamin family.	Stimuli-sensing channels	PE1	11
+NX_Q75VX8	GRB2-associated and regulator of MAPK protein 2	874	92882	6.48	0	Cytosol	NA	Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.	NA	Belongs to the GAREM family.	NA	PE1	2
+NX_Q75WM6	Testis-specific H1 histone	255	28116	11.77	0	Nucleus;Chromosome	NA	Essential for normal spermatogenesis and male fertility (PubMed:16533358). Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1.	NA	Belongs to the histone H1/H5 family.	NA	PE1	12
+NX_Q765I0	Urotensin-2B	119	13749	6.11	0	Secreted	NA	Potent vasoconstrictor.	NA	Belongs to the urotensin-2 family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE2	3
+NX_Q765P7	Protein MTSS 2	747	79929	7.18	0	Ruffle;Cytoplasm;Focal adhesion	NA	Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106).	NA	Belongs to the MTSS family.	NA	PE1	16
+NX_Q76B58	BMP/retinoic acid-inducible neural-specific protein 3	766	88445	8.06	0	Mitochondrion;Secreted	NA	Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.	NA	Belongs to the BRINP family.	NA	PE1	1
+NX_Q76EJ3	UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter	337	36673	8.89	8	Golgi apparatus;Golgi apparatus membrane	NA	Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.	NA	Belongs to the TPT transporter family. SLC35D subfamily.	Transport of nucleotide sugars;Keratan sulfate biosynthesis;HS-GAG biosynthesis	PE1	9
+NX_Q76FK4	Nucleolar protein 8	1167	131616	6.67	0	Nucleolus	NA	Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.	Phosphorylated.	NA	NA	PE1	9
+NX_Q76G19	PDZ domain-containing protein 4	769	86171	5.8	0	Cell cortex	NA	NA	NA	NA	NA	PE1	X
+NX_Q76I76	Protein phosphatase Slingshot homolog 2	1423	158216	5.26	0	Cytoskeleton	NA	Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.	NA	Belongs to the protein-tyrosine phosphatase family.	Regulation of actin cytoskeleton	PE1	17
+NX_Q76KD6	Speriolin	591	62399	8.31	0	Cytoplasm;Centrosome	NA	NA	NA	Belongs to the speriolin family.	NA	PE1	8
+NX_Q76KP1	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1	1039	116513	6.51	1	Golgi stack membrane;Nucleoplasm;Spindle;Cytoskeleton	NA	Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.	NA	Belongs to the chondroitin N-acetylgalactosaminyltransferase family.	NA	PE1	11
+NX_Q76KX8	Zinc finger protein 534	674	77167	9.42	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE2	19
+NX_Q76L83	Putative Polycomb group protein ASXL2	1435	153820	9	0	Nucleoplasm;Nucleus	Shashi-Pena syndrome	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.	NA	Belongs to the Asx family.	UCH proteinases	PE1	2
+NX_Q76LX8	A disintegrin and metalloproteinase with thrombospondin motifs 13	1427	153604	6.96	0	Cytoplasmic vesicle;Secreted	Thrombotic thrombocytopenic purpura congenital	Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.	Glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS13. May also be C-glycosylated on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and also N-glycosylated. These other glycosylations can also facilitate secretion.;The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	9
+NX_Q76M96	Coiled-coil domain-containing protein 80	950	108174	9.72	0	Extracellular matrix	NA	Promotes cell adhesion and matrix assembly.	Phosphorylated.	Belongs to the CCDC80 family.	NA	PE1	3
+NX_Q76MJ5	Serine/threonine-protein kinase/endoribonuclease IRE2	926	102480	6.73	1	Endoplasmic reticulum membrane	NA	Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.	Autophosphorylated.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	16
+NX_Q76N32	Centrosomal protein of 68 kDa	757	81102	5.04	0	Nucleoplasm;Centriolar satellite;Centrosome	NA	Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564).	Phosphorylation by PLK1 is required for binding to BTRC in prometaphase (PubMed:25503564). Phosphorylated directly or indirectly by NEK2 (PubMed:24554434). NEK2-mediated phosphorylation promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143).;Ubiquitinated and targeted for proteasomal degradation in early mitosis by the SCF(BTRC) and/or SCF(FBXW11) E3 ubiquitin-protein ligase complexes (PubMed:25704143, PubMed:25503564). Degradation is complete by prometaphase and is required for removal of CDK5RAP2 from the peripheral pericentriolar material and subsequent centriole separation (PubMed:25503564).	NA	NA	PE1	2
+NX_Q76N89	E3 ubiquitin-protein ligase HECW1	1606	179554	5.33	0	Cytoplasm;Cytosol	NA	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.	NA	NA	Protein modification; protein ubiquitination.;Degradation of DVL	PE1	7
+NX_Q76NI1	Kinase non-catalytic C-lobe domain-containing protein 1	1749	191397	5.83	0	Perikaryon;Dendrite	NA	RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352).	NA	NA	NA	PE1	10
+NX_Q7KYR7	Butyrophilin subfamily 2 member A1	527	59633	6.08	1	Membrane;Cell membrane	NA	NA	NA	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Butyrophilin (BTN) family interactions	PE1	6
+NX_Q7KZ85	Transcription elongation factor SPT6	1726	199073	4.81	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.	NA	Belongs to the SPT6 family.	Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation	PE1	17
+NX_Q7KZF4	Staphylococcal nuclease domain-containing protein 1	910	101997	6.74	0	Cytoplasm;Cytosol;Melanosome;Nucleus	NA	Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:28546213, PubMed:18453631). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity).;(Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).	Phosphorylated by PIM1 in vitro.	NA	Signaling by BRAF and RAF fusions	PE1	7
+NX_Q7KZI7	Serine/threonine-protein kinase MARK2	788	87911	9.73	0	Cytoplasm;Lateral cell membrane;Cell membrane;Nucleoplasm;Dendrite;Cytoskeleton	NA	Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.	Autophosphorylated. Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-208 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-212 by GSK3-beta (GSK3B) inhibits the kinase activity. Phosphorylation by CaMK1 promotes activity and is required to promote neurite outgrowth. Phosphorylation at Thr-596 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity and promotes binding to 14-3-3 protein YWHAZ, leading to relocation from cell membrane to cytoplasm.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	NA	PE1	11
+NX_Q7KZN9	Cytochrome c oxidase assembly protein COX15 homolog	410	46030	9.85	8	Mitochondrion membrane;Mitochondrion	Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2;Leigh syndrome	May be involved in the biosynthesis of heme A.	NA	Belongs to the COX15/CtaA family.	Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.;Oxidative phosphorylation;Porphyrin and chlorophyll metabolism;Metabolic pathways;Heme biosynthesis	PE1	10
+NX_Q7L014	Probable ATP-dependent RNA helicase DDX46	1031	117362	9.33	0	Cajal body;Membrane;Nucleus speckle;Nucleus	NA	Plays an essential role in splicing, either prior to, or during splicing A complex formation.	NA	Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.	Spliceosome;mRNA Splicing - Major Pathway	PE1	5
+NX_Q7L099	Protein RUFY3	469	52965	5.36	0	Cytoplasm;Invadopodium;Endomembrane system;Growth cone;Perikaryon;Cell projection;Lamellipodium;Filopodium;Cytosol	NA	Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321).	Is partially phosphorylated (By similarity).;Phosphorylated by PAK1 (PubMed:25766321).	NA	NA	PE1	4
+NX_Q7L0J3	Synaptic vesicle glycoprotein 2A	742	82695	5.38	12	Endoplasmic reticulum;Cytosol;Synaptic vesicle membrane;Presynapse	NA	(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.;Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).	N-glycosylated.;Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.	Belongs to the major facilitator superfamily.	ECM-receptor interaction;Toxicity of botulinum toxin type D (BoNT/D);Toxicity of botulinum toxin type F (BoNT/F);Toxicity of botulinum toxin type A (BoNT/A);Toxicity of botulinum toxin type E (BoNT/E)	PE1	1
+NX_Q7L0L9	Transmembrane protein LOC653160	218	23184	10.99	2	Membrane	NA	NA	NA	NA	NA	PE2	1
+NX_Q7L0Q8	Rho-related GTP-binding protein RhoU	258	28218	8.39	0	Cell membrane;Podosome;Focal adhesion;Golgi apparatus membrane	NA	Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.	Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation.	Belongs to the small GTPase superfamily. Rho family.	Rho GTPase cycle;Interleukin-4 and Interleukin-13 signaling	PE1	1
+NX_Q7L0R7	RING finger protein 44	432	47728	6.4	0	Nucleoplasm	NA	NA	NA	NA	NA	PE2	5
+NX_Q7L0X0	TLR4 interactor with leucine rich repeats	811	88723	9.7	1	Membrane	NA	Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.	N-glycolysaled.	NA	NA	PE1	7
+NX_Q7L0X2	Glutamate-rich protein 6	663	75255	4.87	0	NA	NA	NA	NA	Belongs to the ERICH6 family.	NA	PE1	3
+NX_Q7L0Y3	tRNA methyltransferase 10 homolog C	403	47347	9.4	0	Nucleoplasm;Mitochondrion;Mitochondrion nucleoid	Combined oxidative phosphorylation deficiency 30	Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297).	NA	Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.	tRNA processing in the mitochondrion;tRNA modification in the mitochondrion;rRNA processing in the mitochondrion	PE1	3
+NX_Q7L190	Developmental pluripotency-associated protein 4	304	33541	9.57	0	Nucleus;Nucleoplasm;Cytosol;Nucleolus	NA	May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.	NA	NA	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	PE1	3
+NX_Q7L1I2	Synaptic vesicle glycoprotein 2B	683	77444	5.26	12	Synaptic vesicle membrane;Acrosome	NA	Probably plays a role in the control of regulated secretion in neural and endocrine cells.;(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.	The N-terminal cytoplasmic domain is phosphorylated by CK1.;N-glycosylated.	Belongs to the major facilitator superfamily.	ECM-receptor interaction;Toxicity of botulinum toxin type D (BoNT/D);Toxicity of botulinum toxin type F (BoNT/F);Toxicity of botulinum toxin type A (BoNT/A);Toxicity of botulinum toxin type E (BoNT/E)	PE1	15
+NX_Q7L1Q6	Basic leucine zipper and W2 domain-containing protein 1	419	48043	5.75	0	Cytoplasmic vesicle	NA	Enhances histone H4 gene transcription but does not seem to bind DNA directly.	NA	Belongs to the BZW family.	NA	PE1	2
+NX_Q7L1S5	Carbohydrate sulfotransferase 9	443	52055	9.41	1	Secreted;Golgi apparatus membrane	NA	But not isoform 1, is active toward chondroitin.;Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta.	NA	Belongs to the sulfotransferase 2 family.	Chondroitin sulfate biosynthesis	PE1	18
+NX_Q7L1T6	Cytochrome b5 reductase 4	521	59474	7.6	0	Endoplasmic reticulum	NA	NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.	NA	Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Erythrocytes take up carbon dioxide and release oxygen	PE1	6
+NX_Q7L1V2	Vacuolar fusion protein MON1 homolog B	547	59217	5.88	0	Cytosol	NA	NA	NA	Belongs to the MON1/SAND family.	RAB GEFs exchange GTP for GDP on RABs	PE1	16
+NX_Q7L1W4	Volume-regulated anion channel subunit LRRC8D	858	98201	7.76	4	Nucleoplasm;Endoplasmic reticulum membrane;Mitochondrion;Cell membrane	NA	Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309).	NA	Belongs to the LRRC8 family.	Miscellaneous transport and binding events	PE1	1
+NX_Q7L211	Protein ABHD13	337	38548	8.74	1	Membrane;Cytosol	NA	NA	NA	Belongs to the serine esterase family.	NA	PE1	13
+NX_Q7L266	Isoaspartyl peptidase/L-asparaginase	308	32055	5.84	0	Nucleoplasm;Cytoplasm;Cytoskeleton	NA	Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.	Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.	Belongs to the Ntn-hydrolase family.	Phenylalanine metabolism	PE1	11
+NX_Q7L273	BTB/POZ domain-containing protein KCTD9	389	42567	5.95	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.	NA	NA	Protein modification; protein ubiquitination.	PE1	8
+NX_Q7L2E3	ATP-dependent RNA helicase DHX30	1194	133938	8.99	0	Cytoplasm;Cytosol;Mitochondrion;Mitochondrion nucleoid	Neurodevelopmental disorder with severe motor impairment and absent language	RNA-dependent helicase (PubMed:29100085). Plays an important role in the assembly of the mitochondrial large ribosomal subunit (PubMed:25683715, PubMed:29100085). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (PubMed:18063578). Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD (By similarity).	Phosphorylated on Ser-15.	Belongs to the DEAD box helicase family. DEAH subfamily.	NA	PE1	3
+NX_Q7L2H7	Eukaryotic translation initiation factor 3 subunit M	374	42503	5.41	0	Cytoplasm;Cytosol;Nucleus	NA	(Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).;Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).	NA	Belongs to the eIF-3 subunit M family.	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	11
+NX_Q7L2J0	7SK snRNA methylphosphate capping enzyme	689	74355	9.62	0	Nucleoplasm;Cell junction	NA	S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.	NA	Belongs to the methyltransferase superfamily.	NA	PE1	7
+NX_Q7L2K0	Tubulin epsilon and delta complex protein 2	433	46402	9.54	0	Nucleoplasm;Cell junction;Cilium;Centriole	NA	Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability.	NA	NA	NA	PE1	16
+NX_Q7L2R6	Zinc finger protein 765	523	61633	8.92	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q7L2Z9	Centromere protein Q	268	30595	9.43	0	Nucleoplasm;Centromere;Nucleus	NA	Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579).	Phosphorylation at Ser-50 is essential for CENPE recruitment to kinetochores and orderly chromosome congression.	Belongs to the CENP-Q/OKP1 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	6
+NX_Q7L311	Armadillo repeat-containing X-linked protein 2	632	65683	8.68	1	Mitochondrion outer membrane;Nucleoplasm;Mitochondrion	NA	May regulate the dynamics and distribution of mitochondria in neural cells.	NA	Belongs to the eutherian X-chromosome-specific Armcx family.	NA	PE1	X
+NX_Q7L3B6	Hsp90 co-chaperone Cdc37-like 1	337	38835	5.22	0	Cytoplasm;Cytosol	NA	Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.	NA	Belongs to the CDC37 family.	Platelet degranulation	PE1	9
+NX_Q7L3S4	Zinc finger protein 771	317	35702	9.15	0	Nucleoplasm;Nucleus;Nucleolus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_Q7L3T8	Probable proline--tRNA ligase, mitochondrial	475	53263	8.45	0	Mitochondrion matrix;Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	1
+NX_Q7L3V2	Protein Bop	364	39299	4.93	0	Mitochondrion	NA	Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.	NA	NA	NA	PE1	22
+NX_Q7L4E1	Mitoguardin 2	593	65531	5.62	2	Mitochondrion outer membrane;Cytosol;Cell junction	NA	Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.	NA	Belongs to the mitoguardin family.	Synthesis of PA	PE1	9
+NX_Q7L4I2	Arginine/serine-rich coiled-coil protein 2	434	50560	11.33	0	Cytoplasm;Nucleus speckle;Nucleolus;Cytosol;Nucleus	NA	NA	NA	Belongs to the RSRC2 family.	NA	PE1	12
+NX_Q7L4P6	BEN domain-containing protein 5	421	48182	5.88	0	Cytosol;Nucleus speckle	NA	Acts as a transcriptional repressor (PubMed:23468431).	NA	NA	NA	PE1	1
+NX_Q7L4S7	Protein ARMCX6	300	33019	4.69	1	Mitochondrion outer membrane;Cytoplasm;Mitochondrion;Cell membrane;Nucleus membrane;Nucleoplasm;Cytosol;Nucleus	NA	May regulate the dynamics and distribution of mitochondria in neural cells.	NA	Belongs to the eutherian X-chromosome-specific Armcx family.	NA	PE1	X
+NX_Q7L513	Fc receptor-like A	359	38927	5.22	0	Cytoplasm	NA	May be implicated in B-cell differentiation and lymphomagenesis.	NA	NA	NA	PE1	1
+NX_Q7L523	Ras-related GTP-binding protein A	313	36566	7.62	0	Cytoplasm;Nucleus;Lysosome	NA	Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.	Ubiquitinated. 'Lys-68'-linked polyubiquitination of the GDP-bound inactive form of RRAGA by RNF152 is increased in response to amino acid starvation. Polyubiquitination promotes interaction with the GATOR1 complex. This does not affect RRAGA degradation.	Belongs to the GTR/RAG GTP-binding protein family.	Macroautophagy;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;mTOR signalling;mTORC1-mediated signalling;E3 ubiquitin ligases ubiquitinate target proteins;Regulation of PTEN gene transcription	PE1	9
+NX_Q7L576	Cytoplasmic FMR1-interacting protein 1	1253	145182	6.46	0	Cytoplasm;Synaptosome;Lamellipodium;Ruffle;Perinuclear region	NA	Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers.	NA	Belongs to the CYFIP family.	Regulation of actin cytoskeleton;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;VEGFA-VEGFR2 Pathway;Neutrophil degranulation	PE1	15
+NX_Q7L590	Protein MCM10 homolog	875	98183	8.96	0	Nucleoplasm;Nucleolus;Nucleus	NA	Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359).	NA	Belongs to the MCM10 family.	Activation of ATR in response to replication stress;Activation of the pre-replicative complex	PE1	10
+NX_Q7L591	Docking protein 3	496	53288	7.93	0	Cytoplasm;Cell membrane	NA	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).	Constitutively tyrosine-phosphorylated.;On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).	Belongs to the DOK family. Type A subfamily.	Neutrophil degranulation	PE1	5
+NX_Q7L592	Protein arginine methyltransferase NDUFAF7, mitochondrial	441	49238	8.47	0	Mitochondrion	NA	Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:20406883, PubMed:24089531, PubMed:24838397). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex (PubMed:24089531).	NA	Belongs to the NDUFAF7 family.	Complex I biogenesis	PE1	2
+NX_Q7L5A3	Protein FAM214B	538	56690	9.09	0	Nucleoplasm;Nucleolus;Nucleus	NA	NA	NA	Belongs to the FAM214 family.	NA	PE1	9
+NX_Q7L5A8	Fatty acid 2-hydroxylase	372	42791	8.76	4	Microsome membrane;Endoplasmic reticulum membrane;Nucleus membrane	Spastic paraplegia 35, autosomal recessive	Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:17355976, PubMed:22517924, PubMed:15863841, PubMed:15337768). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (PubMed:17355976). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (By similarity). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity).	NA	Belongs to the sterol desaturase family. SCS7 subfamily.	Lipid metabolism; fatty acid metabolism.;Sphingolipid metabolism; galactosylceramide biosynthesis.;Sphingolipid de novo biosynthesis	PE1	16
+NX_Q7L5D6	Golgi to ER traffic protein 4 homolog	327	36504	5.29	0	Nucleoplasm;Cytosol;Nucleolus	NA	As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).	Ubiquitinated by RNF12, leading to proteasomal degradation. When unassembled from BAG6; ubiquitinylation is modulated by BAG6 quality control role and effectuated by RNF126.	Belongs to the GET4 family.	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	7
+NX_Q7L5L3	Lysophospholipase D GDPD3	318	36596	8.13	2	Membrane;Nucleoplasm;Endoplasmic reticulum;Cytosol;Perinuclear region;Cytoskeleton	NA	Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) and lysophosphatidylcholine (lyso-PC), and to a lesser extent for lysophosphatidylethanolamine (lyso-PE). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.	NA	Belongs to the glycerophosphoryl diester phosphodiesterase family.	Glycerophospholipid catabolism	PE1	16
+NX_Q7L5N1	COP9 signalosome complex subunit 6	327	36163	5.47	0	Cytoplasm;Nucleoplasm;Perinuclear region;Nucleus	NA	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets.	NA	Belongs to the peptidase M67A family. CSN6 subfamily.	Formation of TC-NER Pre-Incision Complex;DNA Damage Recognition in GG-NER;Cargo recognition for clathrin-mediated endocytosis;Neddylation	PE1	7
+NX_Q7L5N7	Lysophosphatidylcholine acyltransferase 2	544	60208	6.14	1	Endoplasmic reticulum;Golgi apparatus membrane;Endoplasmic reticulum membrane;Lipid droplet	NA	Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Lipid metabolism; phospholipid metabolism.;Glycerophospholipid metabolism;Ether lipid metabolism;Metabolic pathways;Acyl chain remodelling of PC	PE1	16
+NX_Q7L5Y1	Mitochondrial enolase superfamily member 1	443	49786	6.03	0	Mitochondrion	NA	Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329).	Could be sumoylated.	Belongs to the mandelate racemase/muconate lactonizing enzyme family. ENOSF1 subfamily.	NA	PE1	18
+NX_Q7L5Y6	DET1 homolog	550	63848	7.32	0	Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.	NA	Belongs to the DET1 family.	Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	15
+NX_Q7L5Y9	E3 ubiquitin-protein transferase MAEA	396	45287	8.95	0	Cytoplasm;Cell membrane;Nucleus matrix;Nucleoplasm;Cytoskeleton	NA	Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable).	Autoubiquitinated as component of the CTLH E3 ubiquitin-protein ligase complex (in vitro).	NA	NA	PE1	4
+NX_Q7L622	G2/M phase-specific E3 ubiquitin-protein ligase	706	80504	7.9	0	Golgi apparatus;Cytoplasm;Nucleolus;Cytoplasmic vesicle;Cytosol	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.	NA	NA	Protein modification; protein ubiquitination.	PE1	14
+NX_Q7L775	EPM2A-interacting protein 1	607	70370	5.77	0	Endoplasmic reticulum	NA	NA	NA	NA	NA	PE1	3
+NX_Q7L7L0	Histone H2A type 3	130	14121	11.05	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Deiminated on Arg-4 in granulocytes upon calcium entry.;Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).;Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.	Belongs to the histone H2A family.	Systemic lupus erythematosus;RMTs methylate histone arginines;HATs acetylate histones;HDACs deacetylate histones;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs	PE1	1
+NX_Q7L7V1	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32	743	84419	4.88	0	Mitochondrion;Nucleus	NA	NA	NA	Belongs to the DEAD box helicase family. DEAH subfamily.	NA	PE1	10
+NX_Q7L7X3	Serine/threonine-protein kinase TAO1	1001	116070	7.3	0	Cytoplasmic vesicle;Cytoplasm	NA	Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.	Autophosphorylated (By similarity). Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2.;Proteolytically processed by caspase-3 (CASP3).;TAOK1 is phosphorylated by LRRK2;TAOK1 is phosphorylated by ATM;Autophosphorylated	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	MAPK signaling pathway;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	17
+NX_Q7L804	Rab11 family-interacting protein 2	512	58279	9.33	0	Cell membrane;Nucleoplasm;Phagocytic cup;Recycling endosome membrane;Cytoplasmic vesicle	NA	A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.	Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.	NA	Endocytosis;Vasopressin regulates renal water homeostasis via Aquaporins	PE1	10
+NX_Q7L8A9	Tubulinyl-Tyr carboxypeptidase 1	365	40957	9.5	0	Cytoplasm;Secreted	NA	Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096).	2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage (PubMed:16488400). The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu (PubMed:16488400). Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form (PubMed:16488400).;Ubiquitinated in vitro.	Belongs to the transglutaminase-like superfamily. Vasohibin family.	NA	PE1	14
+NX_Q7L8C5	Synaptotagmin-13	426	46885	7.6	1	Membrane;Golgi apparatus;Cytoplasmic vesicle	NA	May be involved in transport vesicle docking to the plasma membrane.	NA	Belongs to the synaptotagmin family.	NA	PE1	11
+NX_Q7L8J4	SH3 domain-binding protein 5-like	393	43499	5.57	0	Golgi apparatus;Nucleoplasm;Cytoplasmic vesicle	NA	Functions as guanine nucleotide exchange factor (GEF) for RAB11A.	NA	Belongs to the SH3BP5 family.	NA	PE1	1
+NX_Q7L8L6	FAST kinase domain-containing protein 5, mitochondrial	764	86574	8.41	0	Mitochondrion nucleoid	NA	Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).	NA	Belongs to the FAST kinase family.	NA	PE1	20
+NX_Q7L8S5	OTU domain-containing protein 6A	288	33300	6.29	0	NA	NA	Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.	NA	NA	NA	PE1	X
+NX_Q7L8W6	Diphthine--ammonia ligase	267	30307	5.24	0	Nucleoplasm;Nucleolus	NA	Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity).	NA	Belongs to the Diphthine--ammonia ligase family.	Protein modification; peptidyl-diphthamide biosynthesis.;Synthesis of diphthamide-EEF2	PE1	15
+NX_Q7L945	Zinc finger protein 627	461	52853	9.18	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q7L985	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2	606	68066	8.44	1	Membrane	NA	NA	NA	NA	NA	PE1	9
+NX_Q7L9B9	Endonuclease/exonuclease/phosphatase family domain-containing protein 1	569	62403	8.64	0	Cytoplasmic vesicle;Nucleus speckle;Cell membrane	NA	NA	NA	NA	NA	PE1	7
+NX_Q7L9L4	MOB kinase activator 1B	216	25091	6.24	0	Cytoplasm;Nucleus	NA	Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.	Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.;MOB1B is phosphorylated by STK4	Belongs to the MOB1/phocein family.	Signaling by Hippo	PE1	4
+NX_Q7LBC6	Lysine-specific demethylase 3B	1761	191581	6.78	0	Nucleoplasm;Nucleus	NA	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.	NA	Belongs to the JHDM2 histone demethylase family.	HDMs demethylate histones	PE1	5
+NX_Q7LBE3	Solute carrier family 26 member 9	791	86988	8.47	13	Membrane;Cell junction	NA	DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.	NA	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Mineral absorption;Multifunctional anion exchangers	PE1	1
+NX_Q7LBR1	Charged multivesicular body protein 1b	199	22109	7.81	0	Late endosome membrane;Nucleoplasm;Endosome;Cytosol;Midbody	NA	Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release.	NA	Belongs to the SNF7 family.	Endocytosis	PE1	18
+NX_Q7LC44	Activity-regulated cytoskeleton-associated protein	396	45316	5.45	0	Dendritic spine;Cell cortex;Cytoskeleton;Extracellular vesicle membrane;Postsynaptic cell membrane;Postsynaptic density;Synapse;Early endosome membrane;Cytoplasmic vesicle;Dendrite;Acrosome	NA	Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity).	Palmitoylation anchors the protein into the membrane by allowing direct insertion into the hydrophobic core of the lipid bilayer.;Ubiquitinated by UBE3A, leading to its degradation by the proteasome, thereby promoting AMPA receptors (AMPARs) expression at synapses.;Phosphorylation at Ser-260 by CaMK2 prevents homooligomerization into virion-like capsids by disrupting an interaction surface essential for high-order oligomerization. Phosphorylation by CaMK2 inhibits synaptic activity.	Belongs to the ARC/ARG3.1 family.	NA	PE1	8
+NX_Q7LDG7	RAS guanyl-releasing protein 2	609	69248	7.89	0	Ruffle membrane;Cytosol;Cell membrane;Synaptosome	Bleeding disorder, platelet-type 18	Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.	Is palmitoylated and myristoylated.	Belongs to the RASGRP family.	MAPK signaling pathway;Chemokine signaling pathway;FCERI mediated NF-kB activation;Effects of PIP2 hydrolysis;Integrin alphaIIb beta3 signaling;Rap1 signalling	PE1	11
+NX_Q7LDI9	Endogenous retrovirus group K member 6 Gag polyprotein	666	74079	9.11	0	Cell membrane	NA	The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).;Specific enzymatic cleavages may yield mature proteins.	Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.	NA	PE1	7
+NX_Q7LFL8	CXXC-type zinc finger protein 5	322	32977	9.27	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).	NA	NA	Estrogen-dependent gene expression	PE1	5
+NX_Q7LFX5	Carbohydrate sulfotransferase 15	561	64926	8.56	1	Cytosol;Centrosome;Golgi apparatus membrane	NA	Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo.	Glycosylated.	Belongs to the sulfotransferase 1 family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Chondroitin sulfate biosynthesis	PE1	10
+NX_Q7LG56	Ribonucleoside-diphosphate reductase subunit M2 B	351	40737	4.89	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Mitochondrial DNA depletion syndrome 8B;Mitochondrial DNA depletion syndrome 8A;Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5	Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.	NA	Belongs to the ribonucleoside diphosphate reductase small chain family.	Genetic information processing; DNA replication.;Purine metabolism;Pyrimidine metabolism;Glutathione metabolism;Metabolic pathways;p53 signaling pathway;TP53 Regulates Metabolic Genes;Interconversion of nucleotide di- and triphosphates	PE1	8
+NX_Q7LGA3	Heparan sulfate 2-O-sulfotransferase 1	356	41881	8.83	1	Mitochondrion;Golgi apparatus membrane	NA	Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity).	N-glycosylated.	Belongs to the sulfotransferase 3 family.	Glycosaminoglycan biosynthesis - heparan sulfate;HS-GAG biosynthesis	PE1	1
+NX_Q7LGC8	Carbohydrate sulfotransferase 3	479	54706	8.84	1	Golgi apparatus;Cytosol;Golgi apparatus membrane	Spondyloepiphyseal dysplasia with congenital joint dislocations	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.	NA	Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Chondroitin sulfate biosynthesis;Defective CHST3 causes SEDCJD	PE1	10
+NX_Q7M4L6	SH2 domain-containing adapter protein F	423	46768	6.01	0	Nucleoplasm	NA	Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.	May become phosphorylated upon binding to PDGFRA.	NA	NA	PE1	15
+NX_Q7RTM1	Proton channel OTOP1	612	67353	8.71	12	Cell membrane	NA	Proton-selective channel that specifically transports protons into cells (PubMed:29371428). Proton channel activity is only weakly-sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PubMed:29371428). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity). Regulates purinergic control of intracellular calcium in vestibular supporting cells (By similarity). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity). Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction (By similarity).	NA	Belongs to the otopetrin family.	NA	PE2	4
+NX_Q7RTN6	STE20-related kinase adapter protein alpha	431	48369	6.02	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	mTOR signaling pathway;Energy dependent regulation of mTOR by LKB1-AMPK	PE1	17
+NX_Q7RTP0	Magnesium transporter NIPA1	329	34562	8.7	9	Early endosome;Cell membrane	Spastic paraplegia 6, autosomal dominant	Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).	NA	Belongs to the NIPA family.	Miscellaneous transport and binding events	PE1	15
+NX_Q7RTP6	[F-actin]-monooxygenase MICAL3	2002	224295	5.43	0	Cytoplasm;Cell cortex;Cytoskeleton;Cell membrane;Cilium basal body;Nucleoplasm;Cytosol;Nucleus;Spindle;Midbody;Midbody ring	NA	Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.	NA	Belongs to the Mical family.	NA	PE1	22
+NX_Q7RTR0	NACHT, LRR and PYD domains-containing protein 9	991	113312	6.08	0	Cytoplasm;Inflammasome	NA	As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments.	NA	Belongs to the NLRP family.	NA	PE1	19
+NX_Q7RTR2	NLR family CARD domain-containing protein 3	1065	114658	8.64	0	Cytoplasmic vesicle;Cytosol;Cytoplasm;Centriolar satellite	NA	Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106).	NA	Belongs to the NLRP family.	IRF3-mediated induction of type I IFN	PE1	16
+NX_Q7RTR8	Taste receptor type 2 member 42	314	36195	9.64	7	Membrane;Nucleoplasm;Focal adhesion;Cytoskeleton	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	12
+NX_Q7RTS1	Class A basic helix-loop-helix protein 15	189	20818	11.26	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).	NA	NA	Maturity onset diabetes of the young	PE1	7
+NX_Q7RTS3	Pancreas transcription factor 1 subunit alpha	328	34970	5.1	0	Cytoplasm;Nucleoplasm;Nucleus	Pancreatic and cerebellar agenesis;Pancreatic agenesis 2	Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.	NA	NA	Regulation of gene expression in early pancreatic precursor cells	PE1	10
+NX_Q7RTS5	Proton channel OTOP3	596	66296	8.96	12	Cell membrane	NA	Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.	NA	Belongs to the otopetrin family.	NA	PE1	17
+NX_Q7RTS6	Proton channel OTOP2	562	62236	7.04	12	Cell membrane	NA	Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.	NA	Belongs to the otopetrin family.	NA	PE1	17
+NX_Q7RTS7	Keratin, type II cytoskeletal 74	529	57865	7.59	0	NA	Ectodermal dysplasia 7, hair/nail type;Hypotrichosis 3;Woolly hair autosomal dominant	Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q7RTS9	Dymeclin	669	75935	5.56	0	Membrane;Cytoplasm;Golgi apparatus	Dyggve-Melchior-Clausen syndrome;Smith-McCort dysplasia 1	Necessary for correct organization of Golgi apparatus. Involved in bone development.	Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment.	Belongs to the dymeclin family.	NA	PE1	18
+NX_Q7RTT3	Putative protein SSX9	188	21553	9.19	0	NA	NA	Could act as a modulator of transcription.	NA	Belongs to the SSX family.	NA	PE5	X
+NX_Q7RTT4	Putative protein SSX8	187	21859	9.46	0	NA	NA	Could act as a modulator of transcription.	NA	Belongs to the SSX family.	NA	PE5	X
+NX_Q7RTT5	Protein SSX7	188	21591	9.19	0	NA	NA	Could act as a modulator of transcription.	NA	Belongs to the SSX family.	NA	PE2	X
+NX_Q7RTT6	Putative protein SSX6	188	21688	9.32	0	NA	NA	Could act as a modulator of transcription.	NA	Belongs to the SSX family.	NA	PE5	X
+NX_Q7RTT9	Equilibrative nucleoside transporter 4	530	58059	7.64	10	Apical cell membrane;Cell membrane;Cytoskeleton	NA	Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.	N-glycosylated.	Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	PE1	7
+NX_Q7RTU0	Transcription factor 24	167	17516	10.24	0	Nucleus	NA	Putative transcription factor.	NA	NA	NA	PE1	8
+NX_Q7RTU1	Transcription factor 23	214	23309	11.33	0	Nucleus speckle;Nucleus	NA	Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).	NA	NA	NA	PE2	2
+NX_Q7RTU3	Oligodendrocyte transcription factor 3	272	29358	9.54	0	Nucleus	NA	May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.	NA	NA	NA	PE1	6
+NX_Q7RTU4	Class A basic helix-loop-helix protein 9	235	24132	11.21	0	Cytoplasm;Nucleus	Syndactyly, mesoaxial synostotic, with phalangeal reduction;Camptosynpolydactyly, complex;Split-hand/foot malformation with long bone deficiency 3	Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis.	NA	NA	NA	PE1	17
+NX_Q7RTU5	Achaete-scute homolog 5	278	29462	8.71	0	Nucleus	NA	NA	NA	NA	NA	PE2	1
+NX_Q7RTU7	Basic helix-loop-helix transcription factor scleraxis	201	21596	10.17	0	Nucleus	NA	Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.	NA	NA	NA	PE2	8
+NX_Q7RTU9	Stereocilin	1775	192967	5.27	0	Stereocilium;Cell surface;Kinocilium	Deafness-infertility syndrome;Deafness, autosomal recessive, 16	Essential to the formation of horizontal top connectors between outer hair cell stereocilia.	NA	Belongs to the stereocilin family.	NA	PE2	15
+NX_Q7RTV0	PHD finger-like domain-containing protein 5A	110	12405	8.79	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes. Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies. Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643, PubMed:28541300). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (By similarity).	NA	Belongs to the PHF5 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	22
+NX_Q7RTV2	Glutathione S-transferase A5	222	25722	7.74	0	Cytoplasm	NA	NA	NA	Belongs to the GST superfamily. Alpha family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation	PE1	6
+NX_Q7RTV3	Zinc finger protein 367	350	38411	8.07	0	Nucleoplasm;Nucleus	NA	Transcriptional activator.;May be involved in transcriptional activation of erythroid genes.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	9
+NX_Q7RTV5	Peroxiredoxin-like 2C	226	24857	9.07	0	NA	NA	May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis.	NA	Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C subfamily.	NA	PE1	9
+NX_Q7RTW8	Otoancorin	1153	128533	5.53	0	Apical cell membrane;Extracellular matrix	Deafness, autosomal recessive, 22	May act as an adhesion molecule.	NA	Belongs to the stereocilin family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	16
+NX_Q7RTX0	Taste receptor type 1 member 3	852	93386	6.75	7	Cell membrane	NA	Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.	NA	Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.	Taste transduction;Carbohydrate digestion and absorption;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	1
+NX_Q7RTX1	Taste receptor type 1 member 1	841	93074	8.32	7	Cell membrane	NA	Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.	NA	Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	1
+NX_Q7RTX7	Cation channel sperm-associated protein 4	472	54092	5.15	6	Flagellum membrane	NA	Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.	NA	Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.	Sperm Motility And Taxes	PE1	1
+NX_Q7RTX9	Monocarboxylate transporter 14	510	56254	6.45	12	Endoplasmic reticulum;Cell membrane	NA	Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	NA	PE1	2
+NX_Q7RTY0	Monocarboxylate transporter 13	426	44992	6.44	12	Golgi apparatus;Cytosol;Golgi apparatus membrane;Cell membrane	Diabetes mellitus, non-insulin-dependent	Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	NA	PE1	17
+NX_Q7RTY1	Monocarboxylate transporter 9	509	55794	8.25	12	Nucleoplasm;Cell junction;Cell membrane	NA	Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	NA	PE1	10
+NX_Q7RTY3	Putative serine protease 45	260	29329	8.42	0	NA	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE5	3
+NX_Q7RTY5	Serine protease 48	328	35970	7.49	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE2	4
+NX_Q7RTY7	Ovochymase-1	1134	125066	8.67	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE1	12
+NX_Q7RTY8	Transmembrane protease serine 7	843	94415	8.84	1	Cell membrane	NA	Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.	N-glycosylated.	Belongs to the peptidase S1 family.	NA	PE1	3
+NX_Q7RTY9	Serine protease 41	318	35078	9.36	0	Cell membrane	NA	NA	N-glycosylated.	Belongs to the peptidase S1 family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	16
+NX_Q7RTZ1	Ovochymase-2	564	62642	7.22	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE1	11
+NX_Q7RTZ2	Ubiquitin carboxyl-terminal hydrolase 17-like protein 1	530	59590	7.81	0	Endoplasmic reticulum;Nucleus	NA	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.	NA	Belongs to the peptidase C19 family. USP17 subfamily.	Ub-specific processing proteases	PE2	8
+NX_Q7Z2D5	Phospholipid phosphatase-related protein type 4	763	82983	9	6	Membrane	NA	Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.	NA	Belongs to the PA-phosphatase related phosphoesterase family.	Lysosphingolipid and LPA receptors	PE1	1
+NX_Q7Z2E3	Aprataxin	356	40740	9.27	0	Nucleoplasm;Cytoplasm;Nucleolus	Ataxia-oculomotor apraxia syndrome	DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).	APTX is phosphorylated by PRKCG (Phosphothreonine:PTM-0254)	NA	NA	PE1	9
+NX_Q7Z2F6	Putative protein ZNF720	126	14454	4.9	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	Generic Transcription Pathway	PE1	16
+NX_Q7Z2G1	Histone H2B type W-T	175	19618	10.69	0	Nucleus membrane;Chromosome	NA	Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.	NA	Belongs to the histone H2B family.	Systemic lupus erythematosus	PE1	X
+NX_Q7Z2H8	Proton-coupled amino acid transporter 1	476	53076	6.54	11	Endoplasmic reticulum;Lysosome membrane;Cell membrane	NA	Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognizes their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity).	NA	Belongs to the amino acid/polyamine transporter 2 family.	Protein digestion and absorption;Amino acid transport across the plasma membrane;Proton-coupled neutral amino acid transporters	PE1	5
+NX_Q7Z2K6	Endoplasmic reticulum metallopeptidase 1	904	100231	7.2	9	Endoplasmic reticulum membrane	NA	Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures.	NA	Belongs to the peptidase M28 family.	NA	PE1	9
+NX_Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	1008	102399	8.33	0	Cytoplasmic vesicle;Growth cone;Cell membrane	NA	May be involved in neurite outgrowth.	Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.	NA	MECP2 regulates neuronal receptors and channels	PE1	5
+NX_Q7Z2Q7	Leucine-rich repeat-containing protein 70	622	70301	9.02	1	Membrane	NA	Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS).	NA	NA	NA	PE1	5
+NX_Q7Z2R9	Putative uncharacterized protein SSBP3-AS1	100	10995	12.15	0	Secreted	NA	NA	NA	NA	NA	PE5	1
+NX_Q7Z2T5	TRMT1-like protein	733	81747	8.11	0	Nucleoplasm;Nucleolus	NA	May play a role in motor coordination and exploratory behavior.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.	NA	PE1	1
+NX_Q7Z2V1	Protein TNT	217	23111	6.41	0	NA	NA	NA	NA	NA	NA	PE1	16
+NX_Q7Z2W4	Zinc finger CCCH-type antiviral protein 1	902	101431	8.72	0	Golgi apparatus;Cytoplasm;Cytosol;Nucleus	NA	Acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).;Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation.;Is a more potent viral inhibitor than isoform 2.	Phosphorylation at Ser-275 is essential for sequential phosphorylation of Ser-271, Ser-267, Ser-263 and Ser-257 by GSK3-beta. Phosphorylation by GSK3-beta enhances its antiviral activity (By similarity).	NA	Signaling by BRAF and RAF fusions	PE1	7
+NX_Q7Z2W7	Transient receptor potential cation channel subfamily M member 8	1104	127685	6.91	6	Endoplasmic reticulum membrane;Membrane raft;Cell membrane	NA	Negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.;Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186).	NA	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily.	TRP channels	PE1	2
+NX_Q7Z2W9	39S ribosomal protein L21, mitochondrial	205	22815	9.91	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bL21 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	11
+NX_Q7Z2X4	PTB-containing, cubilin and LRP1-interacting protein	250	28272	6.53	0	Endoplasmic reticulum;Cytoplasm	NA	Increases proliferation of preadipocytes without affecting adipocytic differentiation.	NA	NA	NA	PE1	2
+NX_Q7Z2X7	P antigen family member 2	111	12090	4	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q7Z2Y5	Nik-related protein kinase	1582	178479	5.93	0	Nucleoplasm;Cytoplasm;Cytosol	NA	May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	NA	PE1	X
+NX_Q7Z2Y8	Interferon-induced very large GTPase 1	2422	279048	6.12	0	Cytosol;Nucleus	NA	NA	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.	NA	PE1	11
+NX_Q7Z2Z1	Treslin	1910	210857	9	0	Nucleoplasm;Nucleus	NA	Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.	NA	Belongs to the treslin family.	NA	PE1	15
+NX_Q7Z2Z2	Elongation factor-like GTPase 1	1120	125430	5.66	0	Cytosol	Shwachman-Diamond syndrome 2	Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.	Ribosome biogenesis in eukaryotes	PE1	15
+NX_Q7Z304	MAM domain-containing protein 2	686	77556	5.05	0	Endoplasmic reticulum;Nucleus speckle;Extracellular matrix;Cell membrane	NA	NA	O-glycosylated.	NA	NA	PE1	9
+NX_Q7Z309	Protein FAM122B	247	26928	5.98	0	Nucleoplasm;Nucleus	NA	NA	Are phosphorylated on Ser-62 and Ser-64.	Belongs to the FAM122 family.	NA	PE1	X
+NX_Q7Z333	Probable helicase senataxin	2677	302880	6.83	0	Cytoplasm;Growth cone;Nucleolus;Chromosome;Nucleoplasm;Telomere;Axon;Nucleus;Cytoskeleton	Amyotrophic lateral sclerosis 4;Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).	Sumoylated preferentially with SUMO2 or SUMO3 (PubMed:24105744, PubMed:24244371).;Ubiquitinated.	Belongs to the DNA2/NAM7 helicase family.	NA	PE1	9
+NX_Q7Z340	Zinc finger protein 551	670	77515	8.73	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q7Z353	Highly divergent homeobox	690	77206	5.61	0	Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	X
+NX_Q7Z388	Probable C-mannosyltransferase DPY19L4	723	83756	8.41	12	Membrane;Endoplasmic reticulum	NA	Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.	NA	Belongs to the dpy-19 family.	NA	PE1	8
+NX_Q7Z392	Trafficking protein particle complex subunit 11	1133	128881	6.72	0	cis-Golgi network;Golgi apparatus	Muscular dystrophy, limb-girdle, autosomal recessive 18	Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.	NA	Belongs to the TRAPPC11 family.	RAB GEFs exchange GTP for GDP on RABs	PE1	4
+NX_Q7Z398	Zinc finger protein 550	422	48381	8.95	0	Cytoplasmic vesicle;Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q7Z3B0	Small integral membrane protein 15	74	8625	9.82	1	Membrane	NA	NA	NA	Belongs to the SMIM15 family.	NA	PE1	5
+NX_Q7Z3B1	Neuronal growth regulator 1	354	38719	5.84	0	Cytoplasmic vesicle;Cytosol;Cell membrane;Cytoskeleton	NA	May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).	NA	Belongs to the immunoglobulin superfamily. IgLON family.	Cell adhesion molecules (CAMs);Post-translational modification: synthesis of GPI-anchored proteins	PE1	1
+NX_Q7Z3B3	KAT8 regulatory NSL complex subunit 1	1105	121025	9	0	Kinetochore;Nucleoplasm;Nucleus	Koolen-De Vries syndrome	As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.	NA	NA	HATs acetylate histones	PE1	17
+NX_Q7Z3B4	Nucleoporin p54	507	55435	6.53	0	Nucleoplasm;Nucleus membrane;Nuclear pore complex	NA	Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.	O-glycosylated.	Belongs to the NUP54 family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	4
+NX_Q7Z3C6	Autophagy-related protein 9A	839	94447	6.19	6	Autophagosome membrane;Endoplasmic reticulum membrane;trans-Golgi network membrane;Endoplasmic reticulum;Cytoplasmic vesicle;Late endosome membrane	NA	Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.	NA	Belongs to the ATG9 family.	Macroautophagy	PE1	2
+NX_Q7Z3D4	LysM and putative peptidoglycan-binding domain-containing protein 3	306	34538	5.62	1	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	5
+NX_Q7Z3D6	D-glutamate cyclase, mitochondrial	616	66437	6.32	0	Mitochondrion matrix;Mitochondrion;Cytosol	NA	D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline.	NA	Belongs to the D-glutamate cyclase family.	NA	PE1	14
+NX_Q7Z3E1	Protein mono-ADP-ribosyltransferase TIPARP	657	76227	6.19	0	Nucleus;Cytoskeleton	NA	ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764).	Auto-mono-ADP-ribosylated.	NA	NA	PE1	3
+NX_Q7Z3E2	Coiled-coil domain-containing protein 186	898	103687	5.94	0	Golgi apparatus	NA	NA	NA	NA	NA	PE1	10
+NX_Q7Z3E5	LisH domain-containing protein ARMC9	818	91819	5.83	0	Cytoplasm;Cilium;Cilium basal body;Centriole	Joubert syndrome 30	Acts as a positive regulator of hedgehog (Hh)signaling (By similarity). Involved in ciliogenesis (By similarity). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity).	NA	NA	NA	PE1	2
+NX_Q7Z3F1	Integral membrane protein GPR155	870	96919	6.42	17	Membrane;Endosome;Nucleus;Cytosol	NA	NA	NA	NA	NA	PE1	2
+NX_Q7Z3G6	Prickle-like protein 2	844	95615	7.12	0	Golgi apparatus;Cytoplasmic vesicle;Nucleus membrane	NA	NA	NA	Belongs to the prickle / espinas / testin family.	Wnt signaling pathway	PE1	3
+NX_Q7Z3H0	Photoreceptor ankyrin repeat protein	452	49403	8.17	0	Cytosol;Nucleus	NA	Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation.	NA	NA	NA	PE2	12
+NX_Q7Z3H4	Sterile alpha motif domain-containing protein 7	446	49112	6.32	0	Cytoplasm;Nucleus	NA	Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes.	NA	NA	NA	PE1	3
+NX_Q7Z3I7	Zinc finger protein 572	529	61238	8.32	0	Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_Q7Z3J2	VPS35 endosomal protein sorting factor-like	963	109563	6.82	1	Cytoplasm;Mitochondrion;Membrane;Endosome;Nucleus	NA	(Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface.;Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947).	NA	Belongs to the VPS35L family.	Neutrophil degranulation	PE1	16
+NX_Q7Z3J3	RanBP2-like and GRIP domain-containing protein 4	1758	197289	5.9	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q7Z3K3	Pogo transposable element with ZNF domain	1410	155344	7.14	0	Cytoplasm;Nucleoplasm;Nucleus;Chromosome	White-Sutton syndrome	Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.	NA	NA	NA	PE1	1
+NX_Q7Z3K6	Mesoderm induction early response protein 3	550	61437	4.42	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor.	NA	NA	NA	PE1	5
+NX_Q7Z3Q1	Solute carrier family 46 member 3	461	51519	5.56	11	Cell membrane;Membrane;Endosome;Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the major facilitator superfamily. SLC46A family.	NA	PE1	13
+NX_Q7Z3S7	Voltage-dependent calcium channel subunit alpha-2/delta-4	1137	127938	5.18	1	Membrane	Retinal cone dystrophy 4	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.	May be proteolytically processed into subunits alpha-2-4 and delta-4 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).	Belongs to the calcium channel subunit alpha-2/delta family.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	12
+NX_Q7Z3S9	Notch homolog 2 N-terminal-like protein A	236	25835	5.44	0	Cytoplasm;Secreted	NA	Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).	Cleaved by ELANE.	Belongs to the NOTCH family.	NA	PE1	1
+NX_Q7Z3T1	Olfactory receptor 2W3	314	34789	8.92	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q7Z3T8	Zinc finger FYVE domain-containing protein 16	1539	168903	4.67	0	Early endosome membrane;Cytoplasm;Cytosol;Cytoplasmic vesicle	NA	May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.	NA	NA	Signaling by BMP	PE1	5
+NX_Q7Z3U7	Protein MON2 homolog	1717	190359	5.72	0	Nucleoplasm;Nucleolus	NA	May be required for traffic between late Golgi and early endosomes.	NA	Belongs to the MON2 family.	NA	PE1	12
+NX_Q7Z3V4	Ubiquitin-protein ligase E3B	1068	123098	8.51	0	Nucleus speckle;Mitochondrion	Kaufman oculocerebrofacial syndrome	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	NA	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	12
+NX_Q7Z3V5	Zinc finger protein 571	609	70792	8.71	0	Nucleoplasm;Nucleolus;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q7Z3Y7	Keratin, type I cytoskeletal 28	464	50567	5.33	0	Cytoplasm	NA	Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs).	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q7Z3Y8	Keratin, type I cytoskeletal 27	459	49822	4.98	0	Cytoplasm	NA	Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q7Z3Y9	Keratin, type I cytoskeletal 26	468	51911	4.86	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q7Z3Z0	Keratin, type I cytoskeletal 25	450	49318	5	0	Cytoplasmic vesicle;Cytoplasm	Woolly hair autosomal recessive 3	Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (PubMed:26902920).	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q7Z3Z2	Protein RD3	195	22704	7.73	0	Cytoplasm;Photoreceptor inner segment;Photoreceptor outer segment;Endosome;Perinuclear region;Nucleus	Leber congenital amaurosis 12	Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:29515371, PubMed:21928830, PubMed:21078983, PubMed:27471269, PubMed:30559291). Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors (PubMed:21928830, PubMed:27471269, PubMed:29515371, PubMed:30559291). Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment (PubMed:21078983). Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP (PubMed:29515371). Plays an important role for the survival of rods and cones in the retina (By similarity).	NA	NA	NA	PE1	1
+NX_Q7Z3Z3	Piwi-like protein 3	882	101089	9.56	0	Cytoplasm	NA	May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).	NA	Belongs to the argonaute family. Piwi subfamily.	Dorso-ventral axis formation	PE1	22
+NX_Q7Z3Z4	Piwi-like protein 4	852	96589	9.09	0	Nucleoplasm;Cytoplasm;Mitochondrion;Nucleus	NA	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Does not show endonuclease activity (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci (PubMed:17544373). In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities. Plays a role in pancreatic beta cell function and insulin secretion (By similarity). Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (PubMed:28025795). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of cells proliferation in tumors (PubMed:22483988).	Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein (TDRD1, TDRKH/TDRD2 and TDRD9) and subsequent localization to the meiotic nuage, also named P granule.	Belongs to the argonaute family. Piwi subfamily.	Dorso-ventral axis formation;PIWI-interacting RNA (piRNA) biogenesis	PE1	11
+NX_Q7Z401	C-myc promoter-binding protein	1863	209244	7.07	0	Nucleoplasm;Nucleolus;Nucleus	NA	Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	15
+NX_Q7Z402	Transmembrane channel-like protein 7	723	83502	8.74	9	Membrane;Cytoplasmic vesicle	NA	Probable ion channel.	NA	Belongs to the TMC family.	NA	PE1	16
+NX_Q7Z403	Transmembrane channel-like protein 6	805	90045	8.98	10	Endoplasmic reticulum membrane	Epidermodysplasia verruciformis 1	Probable ion channel.	NA	Belongs to the TMC family.	Neutrophil degranulation	PE1	17
+NX_Q7Z404	Transmembrane channel-like protein 4	712	79208	9.16	9	Membrane	NA	Probable ion channel.	NA	Belongs to the TMC family.	NA	PE1	19
+NX_Q7Z406	Myosin-14	1995	227871	5.52	0	Nucleoplasm	Peripheral neuropathy, myopathy, hoarseness, and hearing loss;Deafness, autosomal dominant, 4A	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tight junction;Regulation of actin cytoskeleton;Salmonella infection;Viral myocarditis;EPHA-mediated growth cone collapse;RHO GTPases activate PKNs;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate CIT;RHO GTPases activate PAKs;RHO GTPases Activate ROCKs	PE1	19
+NX_Q7Z407	CUB and sushi domain-containing protein 3	3707	406000	5.63	2	Cell membrane	NA	Involved in dendrite development.	NA	Belongs to the CSMD family.	NA	PE1	8
+NX_Q7Z408	CUB and sushi domain-containing protein 2	3487	380039	5.69	1	Cell membrane	NA	NA	NA	Belongs to the CSMD family.	NA	PE1	1
+NX_Q7Z410	Transmembrane protease serine 9	1059	114021	8.46	1	Cell membrane	NA	Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed.	Proteolytically cleaved to generate 3 independent serine protease chains. The cleaved chains may remain attached to the membrane thanks to disulfide bonds. It is unclear whether cleavage always takes place.	Belongs to the peptidase S1 family.	NA	PE1	19
+NX_Q7Z412	Peroxisome assembly protein 26	305	33898	5.94	1	Peroxisome membrane	Peroxisome biogenesis disorder 7B;Peroxisome biogenesis disorder 7A;Peroxisome biogenesis disorder complementation group 8	Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence.	NA	Belongs to the peroxin-26 family.	Peroxisome;Peroxisomal protein import;Class I peroxisomal membrane protein import	PE1	22
+NX_Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	695	76121	8.7	0	Cytoplasm;Stress granule;Nucleoplasm;Cytosol;Nucleus	NA	Binds RNA.	NA	NA	NA	PE1	17
+NX_Q7Z418	Potassium channel subfamily K member 18	384	43671	6.6	4	Cell membrane	Migraine with or without aura 13	Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).	N-glycosylated.;Phosphorylation of Ser-252 is required for the binding of 14-3-3eta/YWHAH. Calcineurin-mediated dephosphorylation of Ser-264 enhances channel activity (By similarity).	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	TWIK-related spinal cord K+ channel (TRESK);Phase 4 - resting membrane potential	PE1	10
+NX_Q7Z419	E3 ubiquitin-protein ligase RNF144B	303	33697	7.62	1	Mitochondrion membrane;Cytoplasm;Mitochondrion;Nucleolus	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.	Auto-ubiquitinated.	Belongs to the RBR family. RNF144 subfamily.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	6
+NX_Q7Z422	SUZ domain-containing protein 1	152	16997	8.92	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the SZRD1 family.	NA	PE1	1
+NX_Q7Z429	Protein lifeguard 1	371	41203	5.21	7	Membrane;Cytosol;Nucleolus	NA	Potential apoptotic regulator.	NA	Belongs to the BI1 family. LFG subfamily.	NA	PE1	8
+NX_Q7Z434	Mitochondrial antiviral-signaling protein	540	56528	5.36	1	Mitochondrion outer membrane;Peroxisome;Mitochondrion	NA	Required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404). Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:25636800). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763).	(Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I production.;Ubiquitinated (PubMed:19881509, PubMed:23087404, PubMed:25636800). Undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation (PubMed:19881509). Ubiquitinated by RNF125, leading to its degradation by the proteasome (PubMed:17460044). Undergoes 'Lys-48'-linked ubiquitination catalyzed by SMURF1 (PubMed:23087404).;(Microbial infection) Cleaved and degraded by hepatitis A virus (HAV) protein 3ABC allowing the virus to disrupt the activation of host IRF3 through the MDA5 pathway.;Following activation, phosphorylated by TBK1 at Ser-442 in the pLxIS motif (PubMed:25636800, PubMed:27302953). The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines (PubMed:25636800).	NA	RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Hepatitis C;Measles;Influenza A;Herpes simplex infection;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;TRAF3-dependent IRF activation pathway;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Ovarian tumor domain proteases	PE1	20
+NX_Q7Z442	Polycystic kidney disease protein 1-like 2	2459	272514	5.51	12	Membrane	NA	May function as an ion-channel regulator. May function as a G-protein-coupled receptor.	NA	Belongs to the polycystin family.	NA	PE1	16
+NX_Q7Z443	Polycystic kidney disease protein 1-like 3	1732	195894	8.78	12	Cell membrane	NA	Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.	NA	Belongs to the polycystin family.	NA	PE1	16
+NX_Q7Z444	GTPase ERas	233	25287	6.1	0	Cell membrane	NA	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity).	NA	Belongs to the small GTPase superfamily. Ras family.	NA	PE1	X
+NX_Q7Z449	Cytochrome P450 2U1	544	61987	8.63	5	Microsome membrane;Golgi apparatus;Endoplasmic reticulum membrane;Nucleoplasm;Cytoplasmic vesicle	Spastic paraplegia 56, autosomal recessive	Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes.	NA	Belongs to the cytochrome P450 family.	Arachidonic acid metabolism;Metabolic pathways;Miscellaneous substrates;Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE);Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)	PE1	4
+NX_Q7Z460	CLIP-associating protein 1	1538	169451	9.14	0	trans-Golgi network;Centrosome;Spindle;Kinetochore;Cytoskeleton	NA	Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.	NA	Belongs to the CLASP family.	Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Recruitment of NuMA to mitotic centrosomes;Role of ABL in ROBO-SLIT signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;AURKA Activation by TPX2	PE1	2
+NX_Q7Z465	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein	357	39713	5.26	0	Cytosol	NA	May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.	NA	NA	NA	PE1	1
+NX_Q7Z478	ATP-dependent RNA helicase DHX29	1369	155236	8.3	0	Cytoplasm;Cytosol	NA	ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.	NA	Belongs to the DEAD box helicase family. DEAH subfamily.	NA	PE1	5
+NX_Q7Z494	Nephrocystin-3	1330	150864	6.31	0	Cilium	Nephronophthisis 3;Meckel syndrome 7;Renal-hepatic-pancreatic dysplasia 1	Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.	NA	NA	Trafficking of myristoylated proteins to the cilium	PE1	3
+NX_Q7Z4B0	Putative uncharacterized protein encoded by LINC00305	112	12600	9.98	0	Secreted	NA	NA	NA	NA	NA	PE5	18
+NX_Q7Z4F1	Low-density lipoprotein receptor-related protein 10	713	76193	5.3	1	Coated pit;Nucleoplasm;Membrane;Nucleolus	NA	Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).	NA	Belongs to the LDLR family.	Retinoid metabolism and transport	PE1	14
+NX_Q7Z4G1	COMM domain-containing protein 6	85	9638	5.69	0	Cytoplasm;Nucleus	NA	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.	NA	NA	Neddylation	PE1	13
+NX_Q7Z4G4	tRNA (guanine(10)-N2)-methyltransferase homolog	463	53421	7.65	0	Nucleus	NA	Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.	tRNA modification in the nucleus and cytosol	PE1	6
+NX_Q7Z4H3	HD domain-containing protein 2	204	23390	5.33	0	Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the HDDC2 family.	NA	PE1	6
+NX_Q7Z4H4	Protein ADM2	148	15865	11.81	0	Secreted	NA	Intermedin-short: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.;Adrenomedullin-2: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.	NA	Belongs to the adrenomedullin family.	G alpha (s) signalling events;Calcitonin-like ligand receptors	PE1	22
+NX_Q7Z4H7	HAUS augmin-like complex subunit 6	955	108621	6.04	0	Nucleus speckle;Centriolar satellite;Centrosome;Cytosol;Spindle;Cytoskeleton	NA	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin.	Phosphorylated during mitosis.	Belongs to the HAUS6 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	9
+NX_Q7Z4H8	Protein O-glucosyltransferase 3	507	58572	8.42	0	Cytoplasmic vesicle;Nucleoplasm;Endoplasmic reticulum lumen	NA	Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1 and NOTCH3 (PubMed:30127001). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001).	NA	Belongs to the KDELC family.	Protein modification; protein glycosylation.	PE1	11
+NX_Q7Z4H9	Protein FAM220A	259	28021	8.86	0	Cytoplasmic vesicle;Nucleus	NA	May negatively regulate STAT3.	NA	NA	NA	PE2	7
+NX_Q7Z4I7	LIM and senescent cell antigen-like-containing domain protein 2	341	38916	8.44	0	Focal adhesion;Nucleus;Cell membrane	Muscular dystrophy, autosomal recessive, with cardiomyopathy and triangular tongue	Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.	NA	NA	Cell-extracellular matrix interactions	PE1	2
+NX_Q7Z4J2	Putative glycosyltransferase 6 domain-containing protein 1	276	32608	9.26	1	Membrane	NA	NA	NA	Belongs to the glycosyltransferase 6 family.	NA	PE5	9
+NX_Q7Z4K8	Tripartite motif-containing protein 46	759	83424	7.99	0	Axon;Cytoskeleton	NA	Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.	NA	Belongs to the TRIM/RBCC family.	Interferon gamma signaling	PE1	1
+NX_Q7Z4L0	Cytochrome c oxidase subunit 8C, mitochondrial	72	8129	12.08	1	Mitochondrion inner membrane	NA	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase VIII family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease	PE2	14
+NX_Q7Z4L5	Tetratricopeptide repeat protein 21B	1316	150937	6.53	0	Mitochondrion;Cilium axoneme	Nephronophthisis 12;Joubert syndrome 11;Short-rib thoracic dysplasia 4 with or without polydactyly	Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs (PubMed:27932497). Negatively modulates the SHH signal transduction (By similarity).	NA	Belongs to the TTC21 family.	Intraflagellar transport;Hedgehog 'off' state	PE1	2
+NX_Q7Z4L9	Protein phosphatase 1 regulatory subunit 42	309	35480	8.79	0	Centrosome;Cytoskeleton	NA	Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.	Phosphorylated; in the testis.	NA	NA	PE2	8
+NX_Q7Z4M0	Meiotic recombination protein REC114	266	29155	5.48	0	NA	NA	Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.	NA	Belongs to the REC114 family.	NA	PE1	15
+NX_Q7Z4N2	Transient receptor potential cation channel subfamily M member 1	1603	182178	6.4	9	Golgi apparatus;Centriolar satellite;Cell membrane	Night blindness, congenital stationary, 1C	Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.	NA	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily.	TRP channels	PE1	15
+NX_Q7Z4N8	Prolyl 4-hydroxylase subunit alpha-3	544	61126	6.05	0	Endoplasmic reticulum lumen	NA	Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.	N-glycosylation plays no role in the catalytic activity.	Belongs to the P4HA family.	Arginine and proline metabolism;Metabolic pathways;Collagen biosynthesis and modifying enzymes	PE1	11
+NX_Q7Z4P5	Growth/differentiation factor 7	450	46950	9.9	0	Secreted	NA	May play an active role in the motor area of the primate neocortex.	NA	Belongs to the TGF-beta family.	TGF-beta signaling pathway	PE1	2
+NX_Q7Z4Q2	HEAT repeat-containing protein 3	680	74583	5.02	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	16
+NX_Q7Z4R8	UPF0669 protein C6orf120	191	20772	4.75	0	Secreted	NA	May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.	NA	Belongs to the UPF0669 family.	Neutrophil degranulation	PE1	6
+NX_Q7Z4S6	Kinesin-like protein KIF21A	1674	187179	6.05	0	Cytosol;Cell membrane;Cytoskeleton	Fibrosis of extraocular muscles, congenital, 1	Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	12
+NX_Q7Z4S9	SH2 domain-containing protein 6	175	19279	9.18	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q7Z4T8	Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5	443	51427	8.88	1	Late endosome membrane	NA	Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	7
+NX_Q7Z4T9	Cilia- and flagella-associated protein 91	767	89955	8.73	0	Cytoplasm;Mitochondrion;Cilium axoneme	NA	May play a role in spermatogenesis (PubMed:12223483). May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).	Phosphorylated by PKA.	NA	NA	PE1	3
+NX_Q7Z4U5	Uncharacterized protein C6orf201	140	16243	10.39	0	NA	NA	NA	NA	NA	NA	PE2	6
+NX_Q7Z4V0	Zinc finger protein 438	828	91836	9.49	0	Nucleoplasm;Cytosol;Nucleus	NA	Acts as a transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	10
+NX_Q7Z4V5	Hepatoma-derived growth factor-related protein 2	671	74317	7.11	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Involved in cellular growth control, through the regulation of cyclin D1 expression.	NA	Belongs to the HDGF family.	NA	PE1	19
+NX_Q7Z4W1	L-xylulose reductase	244	25913	8.33	0	Membrane;Nucleolus;Cytoskeleton	Pentosuria	Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Pentose and glucuronate interconversions;Metabolic pathways;Formation of xylulose-5-phosphate;Essential pentosuria	PE1	17
+NX_Q7Z4W2	Lysozyme-like protein 2	148	16656	8.04	0	Secreted	NA	NA	NA	Belongs to the glycosyl hydrolase 22 family.	NA	PE1	10
+NX_Q7Z4W3	Keratin-associated protein 19-3	81	8247	8.57	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 19 family.	Keratinization	PE2	21
+NX_Q7Z4Y8	Putative ATP synthase subunit g 2, mitochondrial	100	11037	9.91	0	Mitochondrion membrane	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).	NA	Belongs to the ATPase g subunit family.	NA	PE5	22
+NX_Q7Z553	MAM domain-containing glycosylphosphatidylinositol anchor protein 2	956	107436	6.88	0	Cell membrane	NA	May be involved in cell-cell interactions.	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	14
+NX_Q7Z569	BRCA1-associated protein	592	67305	5.64	0	Cytoplasm;Cytosol;Nucleus membrane	NA	Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.	NA	NA	Protein modification; protein ubiquitination.;Negative regulation of MAPK pathway;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	12
+NX_Q7Z570	Zinc finger protein 804A	1209	136888	8.19	0	Endoplasmic reticulum	NA	NA	NA	NA	NA	PE2	2
+NX_Q7Z572	Spermatogenesis-associated protein 21	469	52207	6.74	0	Cytoplasmic vesicle;Cytosol	NA	Involved in the differentiation of haploid spermatids.	NA	NA	NA	PE2	1
+NX_Q7Z589	BRCA2-interacting transcriptional repressor EMSY	1322	141468	9.37	0	Nucleoplasm;Nucleus	NA	Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.	O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.	NA	NA	PE1	11
+NX_Q7Z591	Microtubule organization protein AKNA	1439	155139	5.91	0	Nucleoplasm;Centrosome;Nucleus;Centriole	NA	Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable).	Phosphorylated; phosphorylation regulates dissociation from and reassembly at the centrosome.	Belongs to the AKNA family.	NA	PE1	9
+NX_Q7Z5A4	Putative serine protease 42	293	32006	6.93	0	Cytoplasm;Cell membrane	NA	Plays a role in spermatogenesis. Involved in germ cell survival during meiosis.	NA	Belongs to the peptidase S1 family.	NA	PE5	3
+NX_Q7Z5A7	Chemokine-like protein TAFA-5	132	14301	9.32	0	Secreted	NA	Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity).	NA	Belongs to the TAFA family.	NA	PE1	22
+NX_Q7Z5A8	Chemokine-like protein TAFA-3	133	14776	8.71	0	Secreted	NA	Plays a role in the regulation of microglia polarization.	NA	Belongs to the TAFA family.	NA	PE2	1
+NX_Q7Z5A9	Chemokine-like protein TAFA-1	133	14901	8.49	0	Endoplasmic reticulum;Secreted	NA	Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation.	NA	Belongs to the TAFA family.	NA	PE1	3
+NX_Q7Z5B4	Protein RIC-3	369	41092	5.04	1	Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.	NA	Belongs to the ric-3 family.	NA	PE1	11
+NX_Q7Z5D8	NANOG neighbor homeobox	188	22750	9.73	0	Nucleus	NA	NA	NA	NA	NA	PE2	12
+NX_Q7Z5G4	Golgin subfamily A member 7	137	15824	6.6	0	Golgi apparatus membrane	NA	May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.	Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3.	Belongs to the ERF4 family.	Neutrophil degranulation	PE1	8
+NX_Q7Z5H3	Rho GTPase-activating protein 22	698	76779	8.4	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).	NA	NA	Rho GTPase cycle	PE1	10
+NX_Q7Z5H4	Vomeronasal type-1 receptor 5	357	40779	9.35	7	Cell membrane	NA	Putative pheromone receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	1
+NX_Q7Z5H5	Vomeronasal type-1 receptor 4	301	33557	9.58	7	Cell membrane	NA	Putative pheromone receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	19
+NX_Q7Z5J1	Hydroxysteroid 11-beta-dehydrogenase 1-like protein	315	34288	9.76	0	Cytoplasmic vesicle;Secreted	NA	NA	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	NA	PE1	19
+NX_Q7Z5J4	Retinoic acid-induced protein 1	1906	203352	9.03	0	Nucleoplasm;Cytoplasm;Nucleus	Smith-Magenis syndrome	Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation.	NA	NA	Circadian Clock	PE1	17
+NX_Q7Z5J8	Ankyrin and armadillo repeat-containing protein	1434	162026	8.39	1	Membrane;Nucleoplasm;Centriolar satellite	NA	NA	NA	NA	NA	PE1	2
+NX_Q7Z5K2	Wings apart-like protein homolog	1190	132946	5.27	0	Cytoplasm;Nucleus;Chromosome	NA	Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.	NA	Belongs to the WAPL family.	Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion	PE1	10
+NX_Q7Z5L0	Vitelline membrane outer layer protein 1 homolog	202	21534	4.9	0	Secreted	NA	NA	NA	Belongs to the VMO1 family.	NA	PE1	17
+NX_Q7Z5L2	Coiled-coil domain-containing protein R3HCC1L	792	87883	5.05	0	Nucleoplasm;Nucleus speckle	NA	NA	NA	NA	NA	PE1	10
+NX_Q7Z5L3	Complement C1q-like protein 2	287	29468	5.5	0	Secreted	NA	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).	NA	NA	NA	PE1	2
+NX_Q7Z5L4	Spermatogenesis-associated protein 19, mitochondrial	167	19186	6.44	0	Mitochondrion outer membrane	NA	May have a role in spermiogenesis.	NA	NA	NA	PE1	11
+NX_Q7Z5L7	Podocan	613	68976	6.51	0	Cytoplasm;Extracellular matrix	NA	Negatively regulates cell proliferation and cell migration.	N-glycosylated.	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily.	NA	PE1	1
+NX_Q7Z5L9	Interferon regulatory factor 2-binding protein 2	587	61025	9	0	Cytoplasm;Nucleoplasm;Nucleus	Immunodeficiency, common variable, 14	Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798).	Phosphorylation at Ser-360 is required for nuclear targeting.	Belongs to the IRF2BP family.	NA	PE1	1
+NX_Q7Z5M5	Transmembrane channel-like protein 3	1100	125685	9.28	10	Membrane;Cytosol	NA	Probable ion channel.	NA	Belongs to the TMC family.	NA	PE2	15
+NX_Q7Z5M8	Protein ABHD12B	362	40776	8.57	0	Nucleoplasm	NA	NA	NA	Belongs to the serine esterase family.	NA	PE2	14
+NX_Q7Z5N4	Protein sidekick-1	2213	242112	5.99	1	Cytosol;Synapse;Cell membrane	NA	Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions.	NA	Belongs to the sidekick family.	SDK interactions	PE1	7
+NX_Q7Z5P4	17-beta-hydroxysteroid dehydrogenase 13	300	33655	9.14	0	Golgi apparatus;Endoplasmic reticulum;Cytoplasmic vesicle;Lipid droplet	NA	NA	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Lipid particle organization	PE1	4
+NX_Q7Z5P9	Mucin-19	8384	805253	4.97	0	Secreted	NA	May function in ocular mucus homeostasis.	NA	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	12
+NX_Q7Z5Q1	Cytoplasmic polyadenylation element-binding protein 2	589	64944	6.78	0	Cytoplasm;Cytosol	NA	May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195).	NA	Belongs to the RRM CPEB family.	NA	PE1	4
+NX_Q7Z5Q5	DNA polymerase nu	900	100307	8.57	0	Nucleoplasm;Nucleus	NA	DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template (PubMed:16787914, PubMed:17118716). Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence (PubMed:25775266). May play a role in TLS during interstrand cross-link (ICL) repair (PubMed:19908865). May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents (PubMed:20102227). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904).	NA	Belongs to the DNA polymerase type-A family.	Fanconi Anemia Pathway	PE1	4
+NX_Q7Z5R6	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein	666	73183	5.39	0	Cell membrane;Focal adhesion;Lamellipodium;Cytosol;Cytoskeleton	NA	Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.	NA	Belongs to the MRL family.	MAP2K and MAPK activation;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	10
+NX_Q7Z5S9	Transmembrane protein 144	345	37653	6.63	10	Membrane;Mitochondrion	NA	NA	NA	Belongs to the TMEM144 family.	NA	PE2	4
+NX_Q7Z5U6	WD repeat-containing protein 53	358	38989	6.07	0	Cytosol;Cell membrane	NA	NA	NA	Belongs to the WD repeat WDR53 family.	NA	PE1	3
+NX_Q7Z5V6	Protein phosphatase 1 regulatory subunit 32	425	47295	8.74	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_Q7Z5W3	RNA 5'-monophosphate methyltransferase	292	33200	6.22	0	Nucleoplasm;Cytosol;Cytoplasm	NA	O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA, acting as a capping enzyme (PubMed:28119416). Less efficiently, also methylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing (PubMed:23063121, PubMed:28119416). The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs (PubMed:23063121). There is some controversy about the methylation of pre-miR-145, since the dimethylation first described as the specific enzymatic activity cannot be reproduced by a more recent work which observes a monomehtylation of pre-miR-145 but two orders weaker than the methylation of cytosolic histidyl tRNA (PubMed:23063121, PubMed:28119416, PubMed:30127802).	NA	Belongs to the methyltransferase superfamily.	MicroRNA (miRNA) biogenesis	PE1	12
+NX_Q7Z5Y6	Bone morphogenetic protein 8A	402	44798	9.06	0	Secreted	NA	Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.	NA	Belongs to the TGF-beta family.	Hedgehog signaling pathway;TGF-beta signaling pathway	PE2	1
+NX_Q7Z5Y7	BTB/POZ domain-containing protein KCTD20	419	47480	5.16	0	Endoplasmic reticulum;Cytoplasm;Nucleus speckle	NA	Promotes the phosphorylation of AKT family members.	NA	NA	NA	PE1	6
+NX_Q7Z601	Probable G-protein coupled receptor 142	462	51106	9.52	7	Cytosol;Cell junction;Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	17
+NX_Q7Z602	Probable G-protein coupled receptor 141	305	35464	9.41	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	7
+NX_Q7Z614	Sorting nexin-20	316	36178	8.94	0	Cytoplasm;Cell membrane;Nucleoplasm;Early endosome membrane;Nucleus	NA	May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.	NA	Belongs to the sorting nexin family.	NA	PE1	16
+NX_Q7Z624	Calmodulin-lysine N-methyltransferase	323	36128	6.38	0	Golgi apparatus;Nucleoplasm;Cytoplasm;Nucleus	Hypotonia-cystinuria syndrome	Catalyzes the trimethylation of 'Lys-116' in calmodulin.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family.	Inactivation, recovery and regulation of the phototransduction cascade;Protein methylation	PE1	2
+NX_Q7Z628	Neuroepithelial cell-transforming gene 1 protein	596	67740	9.31	0	Nucleoplasm;Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	10
+NX_Q7Z692	Carcinoembryonic antigen-related cell adhesion molecule 19	300	32638	5.74	1	Membrane;Nucleoplasm;Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	NA	PE2	19
+NX_Q7Z695	Uncharacterized aarF domain-containing protein kinase 2	626	68982	9.03	1	Membrane;Cytosol;Centrosome	NA	The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).	NA	Belongs to the protein kinase superfamily. ADCK protein kinase family.	NA	PE1	7
+NX_Q7Z698	Sprouty-related, EVH1 domain-containing protein 2	418	47558	6.32	0	Cytoplasm;Cell membrane;Nucleoplasm;Secretory vesicle membrane;Cytosol	NA	Negatively regulates Ras signaling pathways and downstream activation of MAP kinases.	Ubiquitinated; leading to degradation by the proteasome.;Phosphorylated on serine and threonine residues (PubMed:15683364). Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination (PubMed:17094949).	NA	Jak-STAT signaling pathway;Regulation of RAS by GAPs;FGFRL1 modulation of FGFR1 signaling;Signaling by RAS mutants	PE1	2
+NX_Q7Z699	Sprouty-related, EVH1 domain-containing protein 1	444	50477	6.12	0	Nucleoplasm;Caveola;Nucleus;Cell membrane	Legius syndrome	Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).	Phosphorylated on tyrosine.	NA	Jak-STAT signaling pathway;Regulation of RAS by GAPs;FGFRL1 modulation of FGFR1 signaling;Signaling by RAS mutants	PE1	15
+NX_Q7Z6A9	B- and T-lymphocyte attenuator	289	32834	6.09	1	Cell membrane	NA	Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).	N-glycosylated.;Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.	NA	Costimulation by the CD28 family	PE1	3
+NX_Q7Z6B0	Coiled-coil domain-containing protein 91	441	49971	5.03	0	trans-Golgi network;Golgi apparatus;trans-Golgi network membrane;Membrane;Nucleoplasm	NA	Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes.	NA	NA	NA	PE1	12
+NX_Q7Z6B7	SLIT-ROBO Rho GTPase-activating protein 1	1085	124264	6.36	0	NA	Thyroid cancer, non-medullary, 2	GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.	NA	NA	Axon guidance;Rho GTPase cycle;Inactivation of CDC42 and RAC1	PE1	12
+NX_Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	1792	201564	9.65	0	Nucleus speckle;Centrosome;Nucleolus;Chromosome	NA	E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).	Phosphorylated by NEK6.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	16
+NX_Q7Z6G3	N-terminal EF-hand calcium-binding protein 2	386	43194	5.33	0	Cytoplasm;Axon;Dendrite;Cell membrane	NA	May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.	NA	NA	NA	PE1	16
+NX_Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	1248	138066	5.93	0	Cajal body;Cytoplasm;Dendritic spine;Cell membrane;Postsynaptic density;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Can regulate global protein synthesis by altering nucleolar numbers.;May play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.;May participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.	Nuclear translocation requires an NMDAR-dependent proteolytic cleavage.	NA	NA	PE1	12
+NX_Q7Z6I5	Spermatogenesis-associated protein 12	190	20418	5.23	0	Nucleoplasm;Cytosol;Mitochondrion;Cell membrane	NA	NA	NA	NA	NA	PE2	3
+NX_Q7Z6I6	Rho GTPase-activating protein 30	1101	118582	4.75	0	Cytoplasmic vesicle	NA	GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.	NA	NA	Rho GTPase cycle	PE1	1
+NX_Q7Z6I8	UPF0461 protein C5orf24	188	20132	9.87	0	Nucleoplasm	NA	NA	NA	Belongs to the UPF0461 family.	NA	PE1	5
+NX_Q7Z6J0	E3 ubiquitin-protein ligase SH3RF1	888	93129	8.85	0	trans-Golgi network;Lamellipodium;Cytoplasmic vesicle;Perinuclear region;Cytoskeleton	NA	(Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity.;Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity).	Phosphorylated at Ser-304 by AKT1 and AKT2. When phosphorylated, it has reduced ability to bind Rac.;Autoubiquitinated (PubMed:20696164). Ubiquitinated by SH3RF2, leading to proteasome-mediated degradation (By similarity).	Belongs to the SH3RF family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	4
+NX_Q7Z6J2	General receptor for phosphoinositides 1-associated scaffold protein	395	42623	9.01	0	Cell membrane;Postsynaptic cell membrane;Cytoplasmic vesicle;Perinuclear region;Nucleus	NA	Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.	NA	NA	NA	PE1	12
+NX_Q7Z6J4	FYVE, RhoGEF and PH domain-containing protein 2	655	74892	6.51	0	Cytoplasm;Early endosome;Early endosome membrane;Ruffle membrane;Nucleus;Cytoskeleton	NA	Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	6
+NX_Q7Z6J6	FERM domain-containing protein 5	570	65065	8.62	1	Membrane;Adherens junction	NA	May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).	NA	NA	NA	PE1	15
+NX_Q7Z6J8	E3 ubiquitin-protein ligase E3D	389	43657	8.51	0	Cytoplasm	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.	Ubiquitinated by UBCH10 (E2 ubiquitin-conjugating enzyme).	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	6
+NX_Q7Z6J9	tRNA-splicing endonuclease subunit Sen54	526	58819	8.04	0	Nucleus;Nucleolus	Pontocerebellar hypoplasia 5;Pontocerebellar hypoplasia 4;Pontocerebellar hypoplasia 2A	Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.	NA	Belongs to the SEN54 family.	tRNA processing in the nucleus	PE1	17
+NX_Q7Z6K1	THAP domain-containing protein 5	395	45416	6.26	0	Nucleoplasm;Nucleus	NA	Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560).	Cleaved by HTRA2 during apoptosis.	NA	NA	PE1	7
+NX_Q7Z6K3	Protein prenyltransferase alpha subunit repeat-containing protein 1	402	46405	6.5	0	Cytoplasm;Centriolar satellite	NA	NA	NA	Belongs to the protein prenyltransferase subunit alpha family.	NA	PE1	9
+NX_Q7Z6K4	Notch-regulated ankyrin repeat-containing protein	114	12492	6.82	0	Nucleoplasm;Cytosol	NA	Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).	NA	Belongs to the NRARP family.	NA	PE1	9
+NX_Q7Z6K5	Arpin	226	24943	5.57	0	Lamellipodium	NA	Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.	NA	Belongs to the Arpin family.	NA	PE1	15
+NX_Q7Z6L0	Proline-rich transmembrane protein 2	340	34945	4.64	1	Dendritic spine;Presynaptic cell membrane;Cell membrane;Synaptic vesicle membrane;Postsynaptic density;Synapse;Axon	Convulsions, familial infantile, with paroxysmal choreoathetosis;Episodic kinesigenic dyskinesia 1;Seizures, benign familial infantile, 2	As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation.	NA	Belongs to the CD225/Dispanin family.	NA	PE1	16
+NX_Q7Z6L1	Tectonin beta-propeller repeat-containing protein 1	1165	129696	5.83	0	Autophagosome membrane;Cytoplasmic vesicle;Lysosome membrane	NA	Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.	NA	Belongs to the TECPR1 family.	NA	PE1	7
+NX_Q7Z6M1	Rab9 effector protein with kelch motifs	372	40565	5.8	0	Cytoplasm;Cell membrane;Endosome membrane	NA	Rab9 effector required for endosome to trans-Golgi network (TGN) transport.	Phosphorylated on Ser residues most probably by PIP5K3.	NA	Retrograde transport at the Trans-Golgi-Network	PE1	9
+NX_Q7Z6M2	F-box only protein 33	555	62630	6.95	0	Nucleoplasm	NA	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).	NA	NA	Protein modification; protein ubiquitination.	PE1	14
+NX_Q7Z6M3	Allergin-1	343	38735	7.91	1	Cell membrane	NA	Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).	N-glycosylated.	NA	NA	PE1	17
+NX_Q7Z6M4	Transcription termination factor 4, mitochondrial	381	43958	4.71	0	Cytosol;Mitochondrion	NA	Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).	The mature mitochondrial protein exists in 2 forms differing at the level of their N-terminus, one is starting at residue 43 and the other at residue 48.	Belongs to the mTERF family.	rRNA modification in the mitochondrion	PE1	2
+NX_Q7Z6P3	Ras-related protein Rab-44	1021	110850	5	0	Cell membrane	NA	NA	NA	Belongs to the small GTPase superfamily. Rab family.	Neutrophil degranulation;RAB geranylgeranylation	PE1	6
+NX_Q7Z6R9	Transcription factor AP-2-delta	452	49578	8.41	0	Nucleus	NA	Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity).	NA	Belongs to the AP-2 family.	Activation of the TFAP2 (AP-2) family of transcription factors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors	PE2	6
+NX_Q7Z6V5	tRNA-specific adenosine deaminase 2	191	21046	6.34	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	Probably participates in deamination of adenosine-34 to inosine in many tRNAs.	NA	Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.	tRNA modification in the nucleus and cytosol	PE1	6
+NX_Q7Z6W1	Transmembrane and coiled-coil domain-containing protein 2	182	20071	8.9	1	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q7Z6W7	DnaJ homolog subfamily B member 7	309	35434	5.34	0	NA	NA	Probably acts as a co-chaperone.	NA	NA	NA	PE2	22
+NX_Q7Z6Z6	Patatin-like phospholipase domain-containing protein 5	429	47912	6.31	0	NA	NA	Lipid hydrolase.	NA	NA	Triglyceride catabolism	PE2	22
+NX_Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	4374	481891	5.1	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	Mental retardation, X-linked, syndromic, Turner type	E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15989957, PubMed:19713937, PubMed:15567145, PubMed:15767685, PubMed:18488021, PubMed:17567951, PubMed:19037095, PubMed:20534529). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529).	Phosphorylated on tyrosine; phosphorylation is probably required for its ability to inhibit TP53 transactivation.	Belongs to the UPL family. TOM1/PTR1 subfamily.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neutrophil degranulation	PE1	X
+NX_Q7Z713	Ankyrin repeat domain-containing protein 37	158	16872	5.75	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE2	4
+NX_Q7Z736	Pleckstrin homology domain-containing family H member 3	793	85317	8.07	0	Golgi apparatus	NA	NA	NA	NA	NA	PE1	17
+NX_Q7Z739	YTH domain-containing family protein 3	585	63861	9.07	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus membrane	NA	Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs and promotes RNA translation efficiency (PubMed:28106072, PubMed:28106076, PubMed:28281539). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28106076, PubMed:28281539). Shares m6A-containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context (PubMed:28106072, PubMed:28106076). Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRNAs and interacting with 40S and 60S ribosome subunits (PubMed:28106072, PubMed:28106076). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs and promoting their translation. Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs) and promotes their translation (PubMed:28281539). CircRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539).	NA	NA	NA	PE1	8
+NX_Q7Z745	Maestro heat-like repeat-containing protein family member 2B	1585	180781	5.9	0	Cytoplasm;Acrosome;Flagellum	NA	May play a role in the process of sperm capacitation.	Constitutively phosphorylated on serine and threonine residues in acrosomal region of the sperm head, midpiece and flagellar regions of noncapacitated spermatozoa. Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal and tail regions in a protein kinase A (PKA)-dependent signaling pathway.	NA	NA	PE1	5
+NX_Q7Z769	Solute carrier family 35 member E3	313	35066	9.29	9	Membrane	NA	Putative transporter.	NA	Belongs to the TPT transporter family. SLC35E subfamily.	NA	PE2	12
+NX_Q7Z794	Keratin, type II cytoskeletal 1b	578	61901	5.73	0	Nucleus membrane;Cell membrane	NA	NA	Undergoes deimination of some arginine residues (citrullination).	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q7Z7A1	Centriolin	2325	268886	5.44	0	Cytosol;Centrosome;Midbody ring	NA	Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.	NA	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Signaling by FGFR1 in disease;Signaling by cytosolic FGFR1 fusion mutants;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	9
+NX_Q7Z7A3	Cytoplasmic tRNA 2-thiolation protein 1	348	36450	9.48	0	Cytoplasm	NA	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.	NA	Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.;Sulfur relay system;tRNA modification in the nucleus and cytosol	PE1	19
+NX_Q7Z7A4	PX domain-containing protein kinase-like protein	578	64950	9.41	0	Cytoplasm;Cytosol;Centriolar satellite;Cell membrane	NA	Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.	NA	Belongs to the protein kinase superfamily.	NA	PE1	3
+NX_Q7Z7B0	Filamin-A-interacting protein 1	1213	138109	8.46	0	Cytoskeleton;Cell membrane	NA	By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.	NA	Belongs to the FILIP1 family.	NA	PE1	6
+NX_Q7Z7B1	Phosphatidylinositol-glycan biosynthesis class W protein	504	56882	9.31	12	Endoplasmic reticulum membrane;Cell membrane	Glycosylphosphatidylinositol biosynthesis defect 11	Required for the transport of GPI-anchored proteins to the plasma membrane (PubMed:24367057). Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity).	NA	Belongs to the PIGW family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	17
+NX_Q7Z7B7	Beta-defensin 132	95	10610	9.72	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	20
+NX_Q7Z7B8	Beta-defensin 128	93	10650	9.08	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	20
+NX_Q7Z7C7	Stimulated by retinoic acid gene 8 protein homolog	330	36908	4.97	0	Cytoplasm;Nucleus	NA	Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. Can associate with DNA (possibly in an indirect manner), and in vitro can activate DNA transcription (By similarity).	Phosphorylated.	NA	NA	PE1	7
+NX_Q7Z7C8	Transcription initiation factor TFIID subunit 8	310	34262	6.03	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).	NA	Belongs to the TAF8 family.	Basal transcription factors;RNA polymerase II transcribes snRNA genes	PE1	6
+NX_Q7Z7D3	V-set domain-containing T-cell activation inhibitor 1	282	30878	5.2	1	Cell junction;Focal adhesion;Cell membrane	NA	Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.	N-glycosylated.	Belongs to the immunoglobulin superfamily. BTN/MOG family.	NA	PE1	1
+NX_Q7Z7E8	Ubiquitin-conjugating enzyme E2 Q1	422	46127	4.96	0	Nucleoplasm;Filopodium;Centrosome;Cytosol;Nucleus	NA	Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity).	Autoubiquitinated in vitro in the presence of NEDD4L.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	1
+NX_Q7Z7F0	KH homology domain-containing protein 4	614	64845	8.84	0	Cytoplasm;Nucleoplasm;Nucleus	NA	RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703).	NA	Belongs to the KHDC4 family.	NA	PE1	1
+NX_Q7Z7F7	39S ribosomal protein L55, mitochondrial	128	15128	11.15	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL55 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	1
+NX_Q7Z7G0	Target of Nesh-SH3	1075	118642	9.48	0	Secreted	NA	NA	NA	NA	NA	PE1	3
+NX_Q7Z7G1	Cytokine-dependent hematopoietic cell linker	428	49554	9.11	0	Cytoplasmic vesicle	NA	Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT (By similarity).	Tyrosine-phosphorylated upon BCR cross-linking. Tyrosine phosphorylation at both Tyr-69 and Tyr-96 are required for BCR-induced calcium response and are essential to restore PLCG2-mediated signaling in BLNK-deficient DT40 cells, but this phosphorylation is dispensable in cells expressing LAT. Interacts with the SH2 domain of PLCG1 via phosphorylated Tyr-96 (By similarity).	NA	NA	PE1	4
+NX_Q7Z7G2	Complexin-4	160	18336	4.54	0	Synapse;Cell membrane	NA	Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity).	Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release.	Belongs to the complexin/synaphin family.	Synaptic vesicle cycle	PE1	18
+NX_Q7Z7G8	Vacuolar protein sorting-associated protein 13B	4022	448664	6.03	0	Cell junction	Cohen syndrome	May be involved in protein sorting in post Golgi membrane traffic.	NA	Belongs to the VPS13 family.	NA	PE1	8
+NX_Q7Z7H3	Ciliogenesis-associated TTC17-interacting protein	387	43900	5.28	0	Cytoplasm;Nucleus;Cytoskeleton;Cell membrane	NA	Plays a role in primary ciliogenesis by modulating actin polymerization.	NA	Belongs to the CATIP family.	NA	PE1	2
+NX_Q7Z7H5	Transmembrane emp24 domain-containing protein 4	227	25943	8.41	1	Endoplasmic reticulum membrane	NA	Involved in vesicular protein trafficking, mainly in the early secretory pathway. Targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).	NA	Belongs to the EMP24/GP25L family.	NA	PE1	7
+NX_Q7Z7H8	39S ribosomal protein L10, mitochondrial	261	29283	9.63	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL10 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	17
+NX_Q7Z7J5	Developmental pluripotency-associated protein 2	298	33784	9.35	0	Nucleoplasm;Nucleus	NA	Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.	NA	NA	NA	PE1	3
+NX_Q7Z7J7	LHFPL tetraspan subfamily member 4 protein	247	27007	6.85	4	Golgi apparatus;Nucleoplasm;Dendrite;Postsynaptic cell membrane	NA	Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs.	NA	Belongs to the LHFP family.	NA	PE1	3
+NX_Q7Z7J9	Calcium/calmodulin-dependent protein kinase II inhibitor 1	78	8553	5.22	0	Postsynaptic density;Synaptosome	NA	Potent and specific inhibitor of CaM-kinase II (CAMK2).	NA	Belongs to the CAMK2N family.	NA	PE1	1
+NX_Q7Z7K0	COX assembly mitochondrial protein homolog	106	12490	8.89	0	Mitochondrion	NA	Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.	NA	Belongs to the CMC family.	NA	PE1	3
+NX_Q7Z7K2	Zinc finger protein 467	595	65124	9.12	0	Mitochondrion;Nucleus	NA	Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Transcriptional regulation of white adipocyte differentiation	PE1	7
+NX_Q7Z7K6	Centromere protein V	275	29946	9.78	0	Kinetochore;Nucleoplasm;Midbody;Cytosol;Spindle;Nucleus	NA	Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.	NA	Belongs to the Gfa family.	NA	PE1	17
+NX_Q7Z7L1	Schlafen family member 11	901	102836	8	0	Nucleoplasm;Nucleus;Chromosome	NA	Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900). Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900).	NA	Belongs to the Schlafen family. Subgroup III subfamily.	NA	PE1	17
+NX_Q7Z7L7	Protein zer-1 homolog	766	88169	5.43	0	Cytosol	NA	Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC (PubMed:17304241, PubMed:31273098). Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098).	NA	Belongs to the zyg-11 family.	NA	PE1	9
+NX_Q7Z7L8	Uncharacterized protein C11orf96	435	46114	10.04	0	Nucleoplasm;Cytosol;Focal adhesion	NA	NA	NA	NA	NA	PE1	11
+NX_Q7Z7L9	Zinc finger and SCAN domain-containing protein 2	614	69547	7.04	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	15
+NX_Q7Z7M0	Multiple epidermal growth factor-like domains protein 8	2845	303100	6.45	1	Membrane	Carpenter syndrome 2	Acts as a negative regulator of hedgehog signaling.	NA	NA	NA	PE1	19
+NX_Q7Z7M1	Adhesion G-protein coupled receptor D2	963	104087	8.33	7	Membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE2	9
+NX_Q7Z7M8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	397	43396	8.66	1	Golgi apparatus membrane	NA	Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;O-linked glycosylation of mucins	PE1	19
+NX_Q7Z7M9	Polypeptide N-acetylgalactosaminyltransferase 5	940	106266	9.51	1	Golgi apparatus;Nucleolus;Golgi apparatus membrane;Cytoplasmic vesicle;Cytosol	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity).	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	2
+NX_Q7Z7N9	Transmembrane protein 179B	219	23550	8.1	4	Membrane;Nucleus speckle	NA	NA	NA	Belongs to the TMEM179 family.	Neutrophil degranulation	PE1	11
+NX_Q86SE5	RNA-binding Raly-like protein	291	32331	7.69	0	Nucleoplasm	NA	NA	NA	Belongs to the RRM HNRPC family. RALY subfamily.	NA	PE1	8
+NX_Q86SE8	Nucleoplasmin-2	214	24152	4.97	0	Nucleoplasm;Nucleus;Nucleolus	NA	Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.	NA	Belongs to the nucleoplasmin family.	NA	PE1	8
+NX_Q86SE9	Polycomb group RING finger protein 5	256	29714	6.11	0	Nucleoplasm;Nucleolus;Centrosome;Nucleus	NA	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).	NA	NA	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	10
+NX_Q86SF2	N-acetylgalactosaminyltransferase 7	657	75389	6.67	1	Golgi apparatus;Nucleoplasm;Golgi apparatus membrane	NA	Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	4
+NX_Q86SG2	Ankyrin repeat domain-containing protein 23	305	34297	9.51	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.	NA	NA	NA	PE1	2
+NX_Q86SG3	Deleted in azoospermia protein 4	579	64785	9.23	0	Cytoplasm;Nucleus	Spermatogenic failure Y-linked 2	RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.	NA	Belongs to the RRM DAZ family.	NA	PE1	Y
+NX_Q86SG4	Putative Dresden prostate carcinoma protein 2	172	20403	9.89	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_Q86SG5	Protein S100-A7A	101	11305	6.89	0	Cytoplasm	NA	May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.	NA	Belongs to the S-100 family.	Metal sequestration by antimicrobial proteins	PE1	1
+NX_Q86SG6	Serine/threonine-protein kinase Nek8	692	74806	8.02	0	Cytoplasm;Centrosome;Cilium;Cytoskeleton	Renal-hepatic-pancreatic dysplasia 2;Nephronophthisis 9	Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.	NA	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	NA	PE1	17
+NX_Q86SG7	Lysozyme g-like protein 2	212	23498	9.03	0	Secreted	NA	May act as a potent antibacterial protein that may play a role in the innate immunity.	NA	Belongs to the glycosyl hydrolase 23 family.	NA	PE1	2
+NX_Q86SH2	Zygote arrest protein 1	424	45873	9.31	0	Cytoplasm	NA	Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity).	NA	Belongs to the ZAR1 family.	NA	PE1	4
+NX_Q86SH4	Putative testis-specific prion protein	94	10756	9.57	0	Secreted	NA	NA	NA	NA	NA	PE5	20
+NX_Q86SI9	Protein CEI	138	15091	11.42	0	Golgi apparatus;Cytoplasmic vesicle;Secreted	NA	NA	NA	NA	NA	PE1	5
+NX_Q86SJ2	Amphoterin-induced protein 2	522	57934	8.73	1	Golgi apparatus;Cytosol;Nucleus;Cell membrane	NA	Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.	NA	Belongs to the immunoglobulin superfamily. AMIGO family.	NA	PE1	12
+NX_Q86SJ6	Desmoglein-4	1040	113824	4.42	1	Desmosome;Cell membrane	Hypotrichosis 6	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).	NA	NA	Formation of the cornified envelope;Keratinization	PE1	18
+NX_Q86SK9	Stearoyl-CoA desaturase 5	330	37610	9.65	4	Endoplasmic reticulum membrane	NA	Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:15610069). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids.	NA	Belongs to the fatty acid desaturase type 1 family.	Biosynthesis of unsaturated fatty acids;PPAR signaling pathway;Fatty acyl-CoA biosynthesis	PE1	4
+NX_Q86SM5	Mas-related G-protein coupled receptor member G	289	31518	9.59	7	Cell membrane	NA	Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.	NA	PE2	11
+NX_Q86SM8	Mas-related G-protein coupled receptor member E	312	34286	8.49	7	Cell membrane	NA	Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.	NA	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.	NA	PE2	11
+NX_Q86SP6	Probable G-protein coupled receptor 149	731	80984	6.56	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	3
+NX_Q86SQ0	Pleckstrin homology-like domain family B member 2	1253	142158	7.06	0	Membrane;Cytoplasm;Cytosol;Cell membrane	NA	Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity).	NA	NA	NA	PE1	3
+NX_Q86SQ3	Putative adhesion G protein-coupled receptor E4P	457	50903	8.7	7	Secreted;Cell membrane	NA	May mediate the cellular interaction between myeloid cells and B-cells.	Glycosylated.;Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE5	19
+NX_Q86SQ4	Adhesion G-protein coupled receptor G6	1221	136695	8.18	7	Cell membrane	Lethal congenital contracture syndrome 9	G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity).	Highly glycosylated.;Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	6
+NX_Q86SQ6	Adhesion G protein-coupled receptor A1	560	60885	8.25	7	Membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	10
+NX_Q86SQ7	Serologically defined colon cancer antigen 8	713	82682	5.59	0	Cytoplasm;Centriole;Cell junction;Cilium basal body;Centrosome	Bardet-Biedl syndrome 16;Senior-Loken syndrome 7	Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062).	NA	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	1
+NX_Q86SQ9	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	333	38657	8.56	0	Endoplasmic reticulum membrane;Cell membrane	Retinitis pigmentosa 59;Developmental delay and seizures with or without movement abnormalities	With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. Condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394).	NA	Belongs to the UPP synthase family.	Protein modification; protein glycosylation.;Lipid metabolism.;Terpenoid backbone biosynthesis;Synthesis of Dolichyl-phosphate;Defective DHDDS causes retinitis pigmentosa 59	PE1	1
+NX_Q86SR1	Polypeptide N-acetylgalactosaminyltransferase 10	603	68992	8.84	1	Golgi apparatus;Nucleoplasm;Golgi apparatus membrane;Cell membrane	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	5
+NX_Q86SS6	Synaptotagmin-9	491	56188	6.79	1	Synaptic vesicle membrane	NA	May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.	NA	Belongs to the synaptotagmin family.	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Neurexins and neuroligins	PE1	11
+NX_Q86SU0	Immunoglobulin-like domain-containing receptor 1	546	62815	9.12	1	Cytosol;Cell membrane	Deafness, autosomal recessive, 42	Putative membrane receptor.	NA	Belongs to the immunoglobulin superfamily. LISCH7 family.	NA	PE1	3
+NX_Q86SX3	Tubulin epsilon and delta complex protein 1	495	54231	8.4	0	Golgi apparatus;Centriole;Cilium;Nucleoplasm;Cytosol	NA	Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability (By similarity). May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F (PubMed:28796488).	NA	NA	NA	PE1	14
+NX_Q86SX6	Glutaredoxin-related protein 5, mitochondrial	157	16628	6.28	0	Mitochondrion matrix;Mitochondrion	Spasticity, childhood-onset, with hyperglycinemia;Anemia, sideroblastic, 3, pyridoxine-refractory	Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (PubMed:20364084). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (PubMed:24334290). Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity).	NA	Belongs to the glutaredoxin family. Monothiol subfamily.	Mitochondrial iron-sulfur cluster biogenesis	PE1	14
+NX_Q86SY8	Putative uncharacterized protein KTN1-AS1	53	5770	5.43	0	NA	NA	NA	NA	NA	NA	PE5	14
+NX_Q86SZ2	Trafficking protein particle complex subunit 6B	158	17983	8.88	0	cis-Golgi network;Endoplasmic reticulum	Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy	Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (PubMed:16025134, PubMed:16828797). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable).	NA	Belongs to the TRAPP small subunits family. BET3 subfamily.	COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs	PE1	14
+NX_Q86T03	Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	277	29470	9.24	2	Phagosome membrane;Lysosome membrane;Late endosome membrane;Cell membrane	NA	Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345).	NA	NA	PI5P Regulates TP53 Acetylation;Synthesis of PIPs in the nucleus	PE1	14
+NX_Q86T13	C-type lectin domain family 14 member A	490	51636	5.98	1	Membrane;Golgi apparatus;Endoplasmic reticulum	NA	NA	NA	NA	NA	PE1	14
+NX_Q86T20	Small integral membrane protein 29	102	11550	6.49	1	Membrane	NA	NA	NA	NA	NA	PE1	6
+NX_Q86T23	Putative ciliary rootlet coiled-coil protein-like 1 protein	111	12396	4.45	0	NA	NA	NA	NA	Belongs to the rootletin family.	NA	PE5	1
+NX_Q86T24	Transcriptional regulator Kaiso	672	74484	4.97	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).	NA	NA	NA	PE1	X
+NX_Q86T26	Transmembrane protease serine 11B	416	46337	9.04	1	Endoplasmic reticulum;Cell membrane	NA	Serine protease.	NA	Belongs to the peptidase S1 family.	NA	PE1	4
+NX_Q86T29	Zinc finger protein 605	641	74376	9.32	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	12
+NX_Q86T65	Disheveled-associated activator of morphogenesis 2	1068	123499	6.36	0	Cytoplasmic vesicle;Nucleoplasm;Cytosol	NA	Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly.	NA	Belongs to the formin homology family.	Wnt signaling pathway	PE1	6
+NX_Q86T75	Neuroblastoma breakpoint family member 11	865	99433	4.75	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE2	1
+NX_Q86T82	Ubiquitin carboxyl-terminal hydrolase 37	979	110170	5.87	0	Nucleoplasm;Nucleolus;Nucleus	NA	Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).	Polyubiquitinated via 'Lys-11'-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its degradation. Able to mediate auto-deubiquitination.;Phosphorylated at Ser-628 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-628 is required for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation.	Belongs to the peptidase C19 family.	Ub-specific processing proteases	PE1	2
+NX_Q86T90	Protein hinderin	577	65373	8.36	0	Cytoplasmic vesicle;Nucleus speckle;Lipid droplet	NA	Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes.	NA	NA	NA	PE1	18
+NX_Q86T96	E3 ubiquitin-protein ligase RNF180	592	68254	8.89	1	Cytosol;Endoplasmic reticulum membrane;Nucleus envelope	NA	E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.	NA	NA	Protein modification; protein ubiquitination.	PE1	5
+NX_Q86TA1	MOB kinase activator 3B	216	25464	8.72	0	NA	NA	Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.	NA	Belongs to the MOB1/phocein family.	NA	PE1	9
+NX_Q86TA4	Putative uncharacterized protein FLJ44553	180	19528	7.57	0	NA	NA	NA	NA	NA	NA	PE5	2
+NX_Q86TB3	Alpha-protein kinase 2	2170	237013	5.14	0	Basolateral cell membrane;Cytosol	NA	Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752).	NA	Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.	NA	PE1	18
+NX_Q86TB9	Protein PAT1 homolog 1	770	86850	6.22	0	Nucleus speckle;P-body;PML body;Cytosol;Nucleus	NA	RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).	NA	Belongs to the PAT1 family.	RNA degradation;mRNA decay by 5' to 3' exoribonuclease	PE1	11
+NX_Q86TC9	Myopalladin	1320	145257	6.33	0	Cytoplasm;Sarcomere;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Z line;Nucleus;Cytoskeleton	Nemaline myopathy 11;Cardiomyopathy, familial restrictive 4;Cardiomyopathy, dilated 1KK;Cardiomyopathy, familial hypertrophic 22	Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.	NA	Belongs to the myotilin/palladin family.	NA	PE1	10
+NX_Q86TD4	Sarcalumenin	932	100788	4.34	0	Sarcoplasmic reticulum lumen	NA	May be involved in the regulation of calcium transport.	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	NA	PE1	16
+NX_Q86TE4	Leucine zipper protein 2	346	38958	8.9	0	Nucleoplasm;Cytosol;Secreted;Cell membrane	NA	NA	NA	NA	NA	PE1	11
+NX_Q86TG1	Transmembrane protein 150A	271	28835	5.45	6	Cell membrane	NA	Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity).	NA	Belongs to the DRAM/TMEM150 family.	NA	PE1	2
+NX_Q86TG7	Retrotransposon-derived protein PEG10	708	80173	5.94	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).	Undergoes proteolytic cleavage.	NA	NA	PE1	7
+NX_Q86TH1	ADAMTS-like protein 2	951	104621	6.02	0	Cytoplasmic vesicle;Secreted	Geleophysic dysplasia 1	NA	Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	9
+NX_Q86TI0	TBC1 domain family member 1	1168	133084	6.52	0	Nucleolus;Nucleus	NA	May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity).	Insulin-stimulated phosphorylation by AKT family kinases stimulates SLC2A4/GLUT4 translocation.	NA	Translocation of SLC2A4 (GLUT4) to the plasma membrane	PE1	4
+NX_Q86TI2	Dipeptidyl peptidase 9	863	98263	6.01	0	Cytosol;Nucleus	NA	Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.	NA	Belongs to the peptidase S9B family. DPPIV subfamily.	NA	PE1	19
+NX_Q86TI4	WD repeat-containing protein 86	376	40731	8.54	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_Q86TJ2	Transcriptional adapter 2-beta	420	48470	7.93	0	Nucleus speckle;Nucleus	NA	Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.	NA	NA	HATs acetylate histones;Ub-specific processing proteases	PE1	4
+NX_Q86TJ5	Zinc finger protein 554	538	60582	7.56	0	Nucleoplasm;Nucleus;Nucleolus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q86TL0	Cysteine protease ATG4D	474	52922	8.93	0	Nucleoplasm;Cytoplasm;Mitochondrion matrix;Mitochondrion	NA	Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.;Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.	Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to mitochondrial import of the protein.	Belongs to the peptidase C54 family.	Regulation of autophagy;Macroautophagy	PE1	19
+NX_Q86TL2	Store-operated calcium entry regulator STIMATE	294	33187	8.28	5	Cytosol;Endoplasmic reticulum membrane	NA	Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574).	NA	Belongs to the STIMATE family.	NA	PE1	3
+NX_Q86TM3	Probable ATP-dependent RNA helicase DDX53	631	71154	9.16	0	Nucleoplasm;Nucleolus;Cytosol;Nucleus	NA	NA	NA	Belongs to the DEAD box helicase family.	NA	PE1	X
+NX_Q86TM6	E3 ubiquitin-protein ligase synoviolin	617	67685	6.47	5	Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum membrane;Cell membrane	NA	Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity).	Not N-glycosylated.;Auto-ubiquitinated.	Belongs to the HRD1 family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;XBP1(S) activates chaperone genes;ER Quality Control Compartment (ERQC)	PE1	11
+NX_Q86TN4	tRNA 2'-phosphotransferase 1	253	27742	10.01	0	Mitochondrion	NA	Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.	NA	Belongs to the KptA/TPT1 family.	NA	PE1	11
+NX_Q86TP1	Exopolyphosphatase PRUNE1	453	50200	5.28	0	Cytoplasm;Cytosol;Focal adhesion;Nucleus	Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies	Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956).	NA	Belongs to the PPase class C family. Prune subfamily.	Purine metabolism	PE1	1
+NX_Q86TS7	Putative UPF0730 protein encoded by LINC00643	51	6040	4.72	0	NA	NA	NA	NA	Belongs to the UPF0730 family.	NA	PE5	14
+NX_Q86TS9	39S ribosomal protein L52, mitochondrial	123	13664	10.27	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL52 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	14
+NX_Q86TU6	Putative uncharacterized protein encoded by LINC00523	105	12089	9.74	0	NA	NA	NA	NA	NA	NA	PE5	14
+NX_Q86TU7	Actin-histidine N-methyltransferase	594	67257	5.72	0	Cytoplasm;Mitochondrion;Nucleus	NA	Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395).	Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation.;Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome.	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD3 subfamily.	PKMTs methylate histone lysines	PE1	14
+NX_Q86TV6	Tetratricopeptide repeat protein 7B	843	94179	6.43	0	Cytosol;Cell membrane	NA	Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (PubMed:26571211).	NA	NA	NA	PE1	14
+NX_Q86TW2	AarF domain-containing protein kinase 1	530	60577	8.84	0	Nucleoplasm;Secreted	NA	Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (PubMed:31125351). The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable).	NA	Belongs to the protein kinase superfamily. ADCK protein kinase family.	NA	PE1	14
+NX_Q86TX2	Acyl-coenzyme A thioesterase 1	421	46277	6.9	0	Cytosol	NA	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20).	NA	Belongs to the C/M/P thioester hydrolase family.	Lipid metabolism; fatty acid metabolism.;Fatty acid elongation;Biosynthesis of unsaturated fatty acids;Mitochondrial Fatty Acid Beta-Oxidation	PE1	14
+NX_Q86TY3	Armadillo-like helical domain-containing protein 4	774	84173	4.26	1	Membrane;Cell membrane	NA	NA	NA	NA	NA	PE1	14
+NX_Q86TZ1	Tetratricopeptide repeat protein 6	520	59379	5.95	0	Centrosome	NA	NA	NA	NA	NA	PE1	14
+NX_Q86U02	Putative uncharacterized protein encoded by LINC00596	117	13541	6.01	1	Membrane	NA	NA	NA	NA	NA	PE5	14
+NX_Q86U06	Probable RNA-binding protein 23	439	48731	9.86	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	Probable RNA-binding protein. May be involved in pre-mRNA splicing process.	NA	Belongs to the splicing factor SR family.	NA	PE1	14
+NX_Q86U10	60 kDa lysophospholipase	573	60883	5.44	0	NA	NA	Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity).	NA	In the N-terminal section; belongs to the asparaginase 1 family.	Aspartate and asparagine metabolism	PE1	14
+NX_Q86U17	Serpin A11	422	46989	7.25	0	Secreted	NA	NA	NA	Belongs to the serpin family.	NA	PE1	14
+NX_Q86U28	Iron-sulfur cluster assembly 2 homolog, mitochondrial	154	16476	5.16	0	Mitochondrion	Multiple mitochondrial dysfunctions syndrome 4	Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.	NA	Belongs to the HesB/IscA family.	Mitochondrial iron-sulfur cluster biogenesis	PE1	14
+NX_Q86U37	Uncharacterized protein encoded by LINC01551	167	18828	9.74	0	NA	NA	NA	NA	NA	NA	PE2	14
+NX_Q86U38	Nucleolar protein 9	636	69438	6.86	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	Belongs to the NOP9 family.	NA	PE1	14
+NX_Q86U42	Polyadenylate-binding protein 2	306	32749	5.04	0	Cytoplasm;Nucleus speckle;Nucleus	Oculopharyngeal muscular dystrophy	Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484).	Arginine dimethylation is asymmetric and involves PRMT1 and PRMT3. It does not influence the RNA binding properties (By similarity).	NA	mRNA surveillance pathway;Influenza A;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;Inhibition of Host mRNA Processing and RNA Silencing;RNA Polymerase II Transcription Termination	PE1	14
+NX_Q86U44	N6-adenosine-methyltransferase catalytic subunit	580	64474	5.98	0	Cytoplasm;Nucleus speckle;Nucleus	NA	The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:28297716, PubMed:30428350, PubMed:29506078, PubMed:29348140, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate to cancer cell proliferation by promoting mRNA translation (PubMed:27117702).	Sumoylation inhibits the N6-adenosine-methyltransferase activity. Sumoylation does not affect subcellular location or interaction with METTL14. Desumoylated by SENP1.	Belongs to the MT-A70-like family.	Processing of Capped Intron-Containing Pre-mRNA	PE1	14
+NX_Q86U70	LIM domain-binding protein 1	411	46533	6.52	0	Nucleoplasm;Nucleus	NA	Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity).	Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome.	Belongs to the LDB family.	RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of expression of SLITs and ROBOs	PE1	10
+NX_Q86U86	Protein polybromo-1	1689	192948	6.46	0	Nucleoplasm;Nucleus	Renal cell carcinoma	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation.	NA	NA	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	3
+NX_Q86U90	YrdC domain-containing protein, mitochondrial	279	29328	8.9	0	Membrane;Mitochondrion	NA	May regulate the activity of some transporters.	NA	Belongs to the SUA5 family.	NA	PE1	1
+NX_Q86UA1	Pre-mRNA-processing factor 39	669	78430	5.26	0	Nucleoplasm;Nucleus	NA	Involved in pre-mRNA splicing.	NA	Belongs to the PRP39 family.	NA	PE1	14
+NX_Q86UA6	RPA-interacting protein	219	24770	4.86	0	Cytoplasm;Nucleolus;Nucleoplasm;PML body;Nucleus	NA	Is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.;Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta.	Sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues. Variant 'Lys-103' adds a sumoylation site and increases total sumoylation levels.	NA	NA	PE1	17
+NX_Q86UB2	Basic immunoglobulin-like variable motif-containing protein	503	56774	9.15	0	Cytoplasm;Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the BIVM family.	NA	PE1	13
+NX_Q86UB9	Transmembrane protein 135	458	52291	9.53	6	Mitochondrion membrane;Peroxisome membrane;Cytoplasmic vesicle	NA	Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.	NA	Belongs to the TMEM135 family.	NA	PE1	11
+NX_Q86UC2	Radial spoke head protein 3 homolog	560	63687	5.53	0	Cell membrane;Cilium;Cilium axoneme;Cytoplasmic vesicle;Cytosol	Ciliary dyskinesia, primary, 32	Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia.	NA	Belongs to the flagellar radial spoke RSP3 family.	NA	PE1	6
+NX_Q86UD0	Suppressor APC domain-containing protein 2	394	42637	9.14	0	Cytoplasm;Cell cortex;Nucleolus;Nucleoplasm;Tight junction;Cytosol;Apical cell membrane;Nucleus	NA	Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824).	NA	NA	NA	PE1	9
+NX_Q86UD1	Out at first protein homolog	273	30688	6.39	0	Nucleoplasm	NA	NA	NA	Belongs to the OAF family.	NA	PE1	11
+NX_Q86UD3	E3 ubiquitin-protein ligase MARCH3	253	28504	8.58	2	Early endosome membrane;Cytoplasmic vesicle;Cytoplasmic vesicle membrane	NA	E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.	NA	NA	Protein modification; protein ubiquitination.	PE1	5
+NX_Q86UD4	Zinc finger protein 329	541	61725	8.94	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q86UD5	Sodium/hydrogen exchanger 9B2	537	57564	6.28	12	Cell membrane;Endosome membrane;Basolateral cell membrane;Cell junction;Flagellum membrane;Nucleoplasm;Synaptic vesicle membrane;Mitochondrion membrane;Apical cell membrane	NA	Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).	NA	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Stimuli-sensing channels	PE1	4
+NX_Q86UD7	TBC1 domain family member 26	250	28839	9.74	0	NA	NA	May act as a GTPase-activating protein for Rab family protein(s).	NA	NA	NA	PE2	17
+NX_Q86UE3	Zinc finger protein 546	836	98405	8.94	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q86UE4	Protein LYRIC	582	63837	9.33	1	Endoplasmic reticulum membrane;Nucleolus;Nucleus membrane;Endoplasmic reticulum;Tight junction;Perinuclear region	NA	Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.	NA	NA	NA	PE1	8
+NX_Q86UE6	Leucine-rich repeat transmembrane neuronal protein 1	522	58641	7.01	1	Postsynaptic cell membrane;Cell membrane	NA	Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.	NA	Belongs to the LRRTM family.	Neurexins and neuroligins	PE1	2
+NX_Q86UE8	Serine/threonine-protein kinase tousled-like 2	772	87661	8.65	0	Perinuclear region;Nucleus;Cytoskeleton	Mental retardation, autosomal dominant 57	Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.	Phosphorylated at Ser-750, probably by CHEK1.;Autophosphorylated (Phosphoserine,Phosphothreonine:PTM-0253,PTM-0254)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	17
+NX_Q86UF1	Tetraspanin-33	283	31538	6.85	4	Cytoplasm;Adherens junction;Cytoskeleton;Cell membrane	NA	Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011).	NA	Belongs to the tetraspanin (TM4SF) family.	Amyloid fiber formation	PE1	7
+NX_Q86UF2	cTAGE family member 6	777	87900	5.09	1	Membrane	NA	NA	NA	Belongs to the cTAGE family.	NA	PE2	7
+NX_Q86UF4	Coiled-coil domain-containing protein 190	302	34103	9.62	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE2	1
+NX_Q86UG4	Solute carrier organic anion transporter family member 6A1	719	79232	8.93	12	Cell membrane	NA	NA	NA	Belongs to the organo anion transporter (TC 2.A.60) family.	NA	PE1	5
+NX_Q86UK0	ATP-binding cassette sub-family A member 12	2595	293237	7.89	14	Cell membrane;Nucleolus;Membrane;Cytoplasmic vesicle;Cytosol	Ichthyosis, congenital, autosomal recessive 4B;Ichthyosis, congenital, autosomal recessive 4A	Probable transporter involved in lipid homeostasis.	NA	Belongs to the ABC transporter superfamily. ABCA family.	ABC transporters;ABC transporters in lipid homeostasis;Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B	PE1	2
+NX_Q86UK5	Limbin	1308	147948	6.53	1	Mitochondrion;Cell membrane;Cilium;Cilium basal body;Cilium membrane;Nucleus	Ellis-van Creveld syndrome;Acrofacial dysostosis, Weyers type	Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis.	NA	NA	Hedgehog 'on' state;Activation of SMO	PE1	4
+NX_Q86UK7	E3 ubiquitin-protein ligase ZNF598	904	98637	8.75	0	Cytosol;Cell membrane	NA	E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931).	NA	Belongs to the ZNF598 family.	NA	PE1	16
+NX_Q86UL3	Glycerol-3-phosphate acyltransferase 4	456	52071	9.28	2	Endoplasmic reticulum membrane	NA	Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:18238778). Active against both saturated and unsaturated long-chain fatty acyl-CoAs (PubMed:18238778).	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.;Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PA	PE1	8
+NX_Q86UL8	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	1455	158754	5.95	0	Cytoplasm;Cell membrane;Late endosome;Synaptosome	Nephrotic syndrome 15	Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.	MAGI2 is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the MAGUK family.	Tight junction;Nephrin family interactions	PE1	7
+NX_Q86UN2	Reticulon-4 receptor-like 1	441	49065	9.25	0	Perikaryon;Membrane raft;Cell projection;Cell membrane	NA	Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).	NA	Belongs to the Nogo receptor family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	17
+NX_Q86UN3	Reticulon-4 receptor-like 2	420	46106	7.58	0	Cell membrane;Perikaryon;Dendrite;Axon;Membrane raft	NA	Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).	N-glycosylated.;Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.	Belongs to the Nogo receptor family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	11
+NX_Q86UN6	A-kinase anchor protein 14	197	22815	6.31	0	Cytoplasm	NA	Binds to type II regulatory subunits of protein kinase A and anchors/targets them.	NA	NA	NA	PE1	X
+NX_Q86UP0	Cadherin-24	819	87752	4.65	1	Cell membrane;Cell junction;Centriolar satellite;Nucleoplasm;Cytosol	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.	NA	NA	Adherens junctions interactions	PE1	14
+NX_Q86UP2	Kinectin	1357	156275	5.52	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.	NA	Belongs to the kinectin family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);RHO GTPases activate KTN1;Post-translational protein phosphorylation	PE1	14
+NX_Q86UP3	Zinc finger homeobox protein 4	3567	393730	5.94	0	Nucleoplasm;Nucleolus;Nucleus	NA	May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_Q86UP6	CUB and zona pellucida-like domain-containing protein 1	607	68153	6.05	1	Cytoplasmic vesicle;Secretory vesicle membrane;Nucleolus	NA	CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.	NA	NA	NA	PE1	10
+NX_Q86UP8	General transcription factor II-I repeat domain-containing protein 2A	949	107168	5.49	0	Nucleus	NA	NA	NA	Belongs to the TFII-I family.	NA	PE1	7
+NX_Q86UP9	LHFPL tetraspan subfamily member 3 protein	236	25769	5.69	4	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the LHFP family.	NA	PE1	7
+NX_Q86UQ0	Zinc finger protein 589	364	41189	8.61	0	Nucleoplasm;Nucleus	NA	May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	3
+NX_Q86UQ4	ATP-binding cassette sub-family A member 13	5058	576159	6.01	14	Membrane;Cytoplasmic vesicle;Cytosol;Centrosome	NA	NA	NA	Belongs to the ABC transporter superfamily.	ABC transporters;Neutrophil degranulation	PE1	7
+NX_Q86UQ5	Gilles de la Tourette syndrome chromosomal region candidate gene 1 protein	136	15623	7.12	1	Membrane	NA	NA	NA	NA	NA	PE5	18
+NX_Q86UQ8	Transcription factor NF-E4	179	19019	9.46	0	Nucleus	NA	Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.	Ubiquitinated; leading to its degradation by the proteasome. Acetylation at Lys-43 prevents ubiquitination.;Acetylation at Lys-43 prolongs the protein half-life by preventing ubiquitin-mediated degradation and reduces the interaction between NF-E4 and HDAC1, potentially maximizing the activating ability of the factor at the gamma-promoter.	NA	NA	PE1	7
+NX_Q86UR1	NADPH oxidase activator 1	476	50933	6.06	0	Cytoplasmic vesicle;Cytoplasm;Cell membrane	NA	Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.	Interaction with YWHAZ depends on phosphorylation by PKA.	Belongs to the NCF2/NOXA1 family.	RHO GTPases Activate NADPH Oxidases	PE1	9
+NX_Q86UR5	Regulating synaptic membrane exocytosis protein 1	1692	189073	9.68	0	Presynaptic cell membrane;Synapse;Cell membrane	Cone-rod dystrophy 7	Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).	Phosphorylated by BRSK1.	NA	Synaptic vesicle cycle;Acetylcholine Neurotransmitter Release Cycle;GABA synthesis, release, reuptake and degradation;Glutamate Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle	PE1	6
+NX_Q86US8	Telomerase-binding protein EST1A	1419	160462	6.66	0	Cytosol;Telomere;Nucleolus	NA	Plays a role in nonsense-mediated mRNA decay (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:18974281, PubMed:19060897, PubMed:20930030, PubMed:17053788).;Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629).	NA	NA	mRNA surveillance pathway;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PE1	17
+NX_Q86UT5	Na(+)/H(+) exchange regulatory cofactor NHE-RF4	571	61032	6.24	0	Cytoplasm;Cell membrane	NA	Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).	NA	NA	Intestinal infectious diseases	PE1	11
+NX_Q86UT6	NLR family member X1	975	107616	7	0	Mitochondrion outer membrane;Cell junction;Mitochondrion;Cell membrane	NA	Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).	NA	Belongs to the NLRP family.	RIG-I-like receptor signaling pathway;Influenza A;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling	PE1	11
+NX_Q86UT8	Coiled-coil domain-containing protein 84	332	37974	8.48	0	Cytoplasm;Nucleoplasm	NA	NA	NA	NA	NA	PE1	11
+NX_Q86UU0	B-cell CLL/lymphoma 9-like protein	1499	157129	8.79	0	Nucleoplasm;Nucleus	NA	Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).	NA	Belongs to the BCL9 family.	Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex	PE1	11
+NX_Q86UU1	Pleckstrin homology-like domain family B member 1	1377	151162	8.85	0	Nucleoplasm;Spindle	NA	NA	NA	NA	NA	PE1	11
+NX_Q86UU5	Gametogenetin	652	66699	10.3	0	NA	NA	May be involved in spermatogenesis.	NA	NA	NA	PE1	19
+NX_Q86UU9	Tachykinin-4	113	12305	5.24	0	Secreted	NA	Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.	NA	Belongs to the tachykinin family.	NA	PE1	17
+NX_Q86UV5	Ubiquitin carboxyl-terminal hydrolase 48	1035	119032	5.75	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	NA	Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites.	NA	Belongs to the peptidase C19 family.	Ub-specific processing proteases	PE1	1
+NX_Q86UV6	Tripartite motif-containing protein 74	250	28547	5.84	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE1	7
+NX_Q86UV7	Tripartite motif-containing protein 73	250	28517	5.95	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE2	7
+NX_Q86UW1	Organic solute transporter subunit alpha	340	37735	8.89	7	Endoplasmic reticulum membrane;Cell membrane	NA	Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.	NA	Belongs to the OST-alpha family.	Bile secretion	PE1	3
+NX_Q86UW2	Organic solute transporter subunit beta	128	14346	4.58	1	Cytoplasmic vesicle;Mitochondrion;Cell membrane	NA	Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.	NA	Belongs to the OST-beta family.	Bile secretion	PE1	15
+NX_Q86UW6	NEDD4-binding protein 2	1770	198801	5.11	0	Nucleoplasm;Cytoplasm;Cytosol;Cell membrane	NA	Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.	Ubiquitinated; this targets the protein for degradation by the proteasome.	NA	NA	PE1	4
+NX_Q86UW7	Calcium-dependent secretion activator 2	1296	147735	5.83	0	Cytoplasmic vesicle membrane;Nucleoplasm;Synapse;Cytoplasmic vesicle	NA	Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).	NA	NA	NA	PE1	7
+NX_Q86UW8	Hyaluronan and proteoglycan link protein 4	402	42801	9.12	0	Extracellular matrix	NA	Binds to hyaluronic acid and may be involved in formation of the extracellular matrix.	NA	Belongs to the HAPLN family.	NA	PE1	19
+NX_Q86UW9	Probable E3 ubiquitin-protein ligase DTX2	622	67246	8.79	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleus membrane	NA	Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.	NA	Belongs to the Deltex family.	Protein modification; protein ubiquitination.;Notch signaling pathway;Activated NOTCH1 Transmits Signal to the Nucleus	PE1	7
+NX_Q86UX2	Inter-alpha-trypsin inhibitor heavy chain H5	942	104576	8.47	0	Golgi apparatus;Secreted;Cytoplasmic vesicle	NA	May act as a tumor suppressor.	NA	Belongs to the ITIH family.	NA	PE1	10
+NX_Q86UX6	Serine/threonine-protein kinase 32C	486	54994	6.16	0	NA	NA	NA	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	10
+NX_Q86UX7	Fermitin family homolog 3	667	75953	6.53	0	Cytoplasmic vesicle;Podosome	Leukocyte adhesion deficiency 3	Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).;May act as a repressor of NF-kappa-B and apoptosis.	NA	Belongs to the kindlin family.	Platelet degranulation	PE1	11
+NX_Q86UY5	Protein FAM83A	434	47458	9.04	0	Nucleoplasm;Cytoplasm	NA	Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation.	Phosphorylated upon EGFR activation.	Belongs to the FAM83 family.	NA	PE1	8
+NX_Q86UY6	N-alpha-acetyltransferase 40	237	27194	7.06	0	Cytoplasm;Nucleus	NA	N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (PubMed:21935442, PubMed:25619998). Acts as a negative regulator of apoptosis (PubMed:26666750). May play a role in hepatic lipid metabolism (By similarity).	NA	Belongs to the acetyltransferase family. NAA40 subfamily.	NA	PE1	11
+NX_Q86UY8	5'-nucleotidase domain-containing protein 3	548	63420	8.46	0	Cytosol;Mitochondrion	NA	NA	NA	Belongs to the 5'(3')-deoxyribonucleotidase family.	NA	PE1	12
+NX_Q86UZ6	Zinc finger and BTB domain-containing protein 46	589	64083	5.55	0	Nucleoplasm;Nucleus	NA	Function as a transcriptional repressor for PRDM1.	Sumoylated. Desumoylation by DESI1 reverses transcriptional repression activity (By similarity).	NA	NA	PE1	20
+NX_Q86V15	Zinc finger protein castor homolog 1	1759	190069	6.59	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441).	NA	NA	NA	PE1	1
+NX_Q86V20	Shieldin complex subunit 2	835	93705	6.41	0	Nucleoplasm;Cytoskeleton;Nucleus;Chromosome	NA	Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).	NA	Belongs to the SHLD2 family.	NA	PE1	10
+NX_Q86V21	Acetoacetyl-CoA synthetase	672	75144	5.86	0	Cytoplasmic vesicle;Cytosol	NA	Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Butanoate metabolism;Synthesis of Ketone Bodies	PE1	12
+NX_Q86V24	Adiponectin receptor protein 2	386	43884	6.11	7	Cell membrane	NA	Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).	NA	Belongs to the ADIPOR family.	Adipocytokine signaling pathway;AMPK inhibits chREBP transcriptional activation activity	PE1	12
+NX_Q86V25	Tubulinyl-Tyr carboxypeptidase 2	355	40450	10.02	0	Cytoplasm;Cytosol;Secreted	NA	Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325).	NA	Belongs to the transglutaminase-like superfamily. Vasohibin family.	NA	PE1	1
+NX_Q86V35	Calcium-binding protein 7	215	24453	4.56	1	trans-Golgi network membrane;Perinuclear region;Cell membrane	NA	Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.	NA	NA	NA	PE1	22
+NX_Q86V40	Metalloprotease TIKI1	505	57676	9.03	1	Cell membrane	NA	Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.	NA	Belongs to the TIKI family.	NA	PE1	2
+NX_Q86V42	Protein FAM124A	546	60104	6.12	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the FAM124 family.	NA	PE1	13
+NX_Q86V48	Leucine zipper protein 1	1076	120275	8.67	0	Cytoplasmic vesicle;Cytosol;Nucleus;Cytoskeleton	NA	NA	NA	NA	NA	PE1	1
+NX_Q86V59	Paraneoplastic antigen-like protein 8A	439	48161	9.09	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	Belongs to the PNMA family.	NA	PE1	19
+NX_Q86V71	Zinc finger protein 429	674	78152	9.5	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	Generic Transcription Pathway	PE2	19
+NX_Q86V81	THO complex subunit 4	257	26888	11.15	0	Cytoplasm;Nucleus speckle;Nucleus	NA	Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation.;Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway) (PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:11707413, PubMed:11675789, PubMed:11979277, PubMed:18364396, PubMed:22144908, PubMed:22893130, PubMed:23222130, PubMed:25662211). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm (PubMed:15833825, PubMed:15998806, PubMed:17190602). TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1 (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA (PubMed:18974867). Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC) (PubMed:15998806, PubMed:17984224). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim (PubMed:19165146). Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability (PubMed:12438613, PubMed:17984224). Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling (PubMed:28418038).	Arg-204 is dimethylated, probably to asymmetric dimethylarginine. Arginine methylation reduces RNA binding.;Citrullinated by PADI4.	Belongs to the ALYREF family.	RNA transport;mRNA surveillance pathway;Spliceosome;Herpes simplex infection;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	17
+NX_Q86V85	Integral membrane protein GPR180	440	49395	7.01	7	Membrane;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	13
+NX_Q86V86	Serine/threonine-protein kinase pim-3	326	35891	5.75	0	Cytoplasm;Cytosol	NA	Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.	Ubiquitinated, leading to proteasomal degradation.;Phosphorylated. Interaction with PPP2CA promotes dephosphorylation.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.	NA	PE1	22
+NX_Q86V87	Protein FAM160B2	743	82340	5.27	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the UPF0518 family.	NA	PE1	8
+NX_Q86V88	Magnesium-dependent phosphatase 1	176	20109	5.95	0	Nucleoplasm	NA	Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.	NA	Belongs to the HAD-like hydrolase superfamily.	NA	PE1	14
+NX_Q86V97	Kelch repeat and BTB domain-containing protein 6	674	76138	5.74	0	NA	NA	NA	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	13
+NX_Q86VB7	Scavenger receptor cysteine-rich type 1 protein M130	1156	125451	5.61	1	Secreted;Cell membrane	NA	After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.;Exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.;Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.	Phosphorylated.;A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs.	NA	Scavenging of heme from plasma	PE1	12
+NX_Q86VD1	MORC family CW-type zinc finger protein 1	984	112881	8.11	0	Nucleus	NA	Required for spermatogenesis.	NA	NA	NA	PE1	3
+NX_Q86VD7	Mitochondrial coenzyme A transporter SLC25A42	318	35409	10.08	6	Mitochondrion inner membrane;Mitochondrion	Metabolic crises, recurrent, with variable encephalomyopathic features and neurologic regression	Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	19
+NX_Q86VD9	GPI mannosyltransferase 4	579	63471	8.66	8	Cytoplasmic vesicle;Endoplasmic reticulum membrane	NA	Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues.	NA	Belongs to the glycosyltransferase 22 family. PIGZ subfamily.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Synthesis of glycosylphosphatidylinositol (GPI)	PE2	3
+NX_Q86VE0	Myb-related transcription factor, partner of profilin	399	42508	10.08	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).	NA	NA	NA	PE1	19
+NX_Q86VE3	Spermidine/spermine N(1)-acetyltransferase-like protein 1	695	75812	5.16	0	NA	NA	NA	NA	Belongs to the acetyltransferase family.	NA	PE1	X
+NX_Q86VE9	Serine incorporator 5	423	47009	7.88	9	Cell membrane;Centrosome;Cytoplasmic vesicle;Cytosol;Perinuclear region	NA	Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).	NA	Belongs to the TDE1 family.	Serine biosynthesis	PE1	5
+NX_Q86VF2	Immunoglobulin-like and fibronectin type III domain-containing protein 1	1251	137763	7.51	0	Z line;Nucleus;Midbody ring	NA	NA	NA	NA	NA	PE1	1
+NX_Q86VF5	2-acylglycerol O-acyltransferase 3	341	38730	8.86	3	Endoplasmic reticulum membrane;Perinuclear region;Centrosome	NA	Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes.	Ubiquitinated. Ubiquitination leads to proteasomal degradation.	Belongs to the diacylglycerol acyltransferase family.	Glycerolipid metabolism; triacylglycerol biosynthesis.;Glycerolipid metabolism;Metabolic pathways;Fat digestion and absorption;Triglyceride biosynthesis	PE1	7
+NX_Q86VF7	Nebulin-related-anchoring protein	1730	197074	9.24	0	Centrosome	NA	May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.	NA	NA	NA	PE1	10
+NX_Q86VG3	Protein C11orf74	221	25407	4.39	0	Cytosol	NA	Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex.	NA	NA	NA	PE1	11
+NX_Q86VH2	Kinesin-like protein KIF27	1401	160283	6.9	0	Cilium;Cytoskeleton	NA	Plays an essential role in motile ciliogenesis.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	9
+NX_Q86VH4	Leucine-rich repeat transmembrane neuronal protein 4	590	67217	9.12	1	Postsynaptic cell membrane;Cell membrane	NA	May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).	NA	Belongs to the LRRTM family.	Neurexins and neuroligins	PE1	2
+NX_Q86VH5	Leucine-rich repeat transmembrane neuronal protein 3	581	65896	9.28	1	Nucleoplasm;Cell membrane;Nucleus;Postsynaptic cell membrane	NA	Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system.	NA	Belongs to the LRRTM family.	Neurexins and neuroligins	PE1	10
+NX_Q86VI1	Exocyst complex component 3-like protein	746	81678	5.44	0	Cytoplasmic vesicle;Secretory vesicle;Cell membrane	NA	As part of the exocyst, may play a role in regulated exocytosis of insulin granules.	NA	Belongs to the SEC6 family.	NA	PE1	16
+NX_Q86VI3	Ras GTPase-activating-like protein IQGAP3	1631	184699	7.34	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	Regulation of actin cytoskeleton;RHO GTPases activate IQGAPs	PE1	1
+NX_Q86VI4	Lysosomal-associated transmembrane protein 4B	317	35123	9.05	4	Golgi apparatus;Cell membrane;Endosome membrane;Endomembrane system;Lysosome membrane;Cell projection;Late endosome membrane;Multivesicular body membrane;Multivesicular body lumen	NA	Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).	Undergoes proteolytic cleavage following delivery to the lysosomes.;Ubiquitinated by NEDD4.	Belongs to the LAPTM4/LAPTM5 transporter family.	Lysosome	PE1	8
+NX_Q86VK4	Zinc finger protein 410	478	52113	5.86	0	Nucleus	NA	Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.	Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation.	NA	NA	PE1	14
+NX_Q86VL8	Multidrug and toxin extrusion protein 2	602	65085	8.63	13	Endoplasmic reticulum;Cell membrane	NA	Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.	NA	Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.	Transport of bile salts and organic acids, metal ions and amine compounds	PE1	17
+NX_Q86VM9	Zinc finger CCCH domain-containing protein 18	953	106378	8.39	0	Nucleus speckle;Nucleus	NA	NA	NA	NA	NA	PE1	16
+NX_Q86VN1	Vacuolar protein-sorting-associated protein 36	386	43817	6.75	0	Cytoplasm;Cell membrane;Cell junction;Membrane;Endosome;Late endosome;Lysosome;Cytoplasmic vesicle;Nucleus	NA	Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.	NA	Belongs to the VPS36 family.	Endocytosis;Endosomal Sorting Complex Required For Transport (ESCRT)	PE1	13
+NX_Q86VP1	Tax1-binding protein 1	789	90877	5.3	0	Nucleoplasm;Cytosol;Nucleus	NA	Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.	Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.	NA	Negative regulators of DDX58/IFIH1 signaling;Regulation of TNFR1 signaling	PE1	7
+NX_Q86VP3	Phosphofurin acidic cluster sorting protein 2	889	97702	6.15	0	Endoplasmic reticulum;Mitochondrion	Epileptic encephalopathy, early infantile, 66	Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.	NA	Belongs to the PACS family.	NA	PE1	14
+NX_Q86VP6	Cullin-associated NEDD8-dissociated protein 1	1230	136376	5.52	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol;Nucleus	NA	Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.	NA	Belongs to the CAND family.	Iron uptake and transport;Neutrophil degranulation;Neddylation	PE1	12
+NX_Q86VQ0	Lebercilin	697	80554	7.31	0	Cilium;Cilium basal body;Centrosome;Cilium axoneme;Cytoskeleton	Leber congenital amaurosis 5	Involved in intraflagellar protein (IFT) transport in photoreceptor cilia.	NA	Belongs to the LCA5 family.	NA	PE1	6
+NX_Q86VQ1	Glucocorticoid-induced transcript 1 protein	547	58024	9.54	0	Nucleolus	NA	NA	NA	NA	NA	PE1	7
+NX_Q86VQ3	Thioredoxin domain-containing protein 2	553	60404	4.81	0	Cytoplasm	NA	Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.	NA	NA	NA	PE1	18
+NX_Q86VQ6	Thioredoxin reductase 3	643	70683	8.13	0	Cytoplasm;Microsome;Nucleoplasm;Endoplasmic reticulum;Cytosol;Nucleus	NA	Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).	NA	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Pyrimidine metabolism;Selenocompound metabolism	PE1	3
+NX_Q86VR2	Reticulophagy regulator 3	466	51396	4.83	3	Membrane;Nucleoplasm;Cytosol;Nucleus membrane	NA	Mediates NRF1-enhanced neurite outgrowth.	NA	Belongs to the RETREG family.	NA	PE1	17
+NX_Q86VR7	V-set and immunoglobulin domain-containing protein 10-like	867	91625	7.91	1	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q86VR8	Four-jointed box protein 1	437	48507	10.66	0	Cytoplasmic vesicle;Secreted	NA	Acts as an inhibitor of dendrite extension and branching.	Glycosylated.;Undergoes proteolytic cleavage.	Belongs to the FJX1/FJ family.	NA	PE1	11
+NX_Q86VS3	IQ domain-containing protein H	1027	117349	9.19	0	Cytosol	NA	May play a regulatory role in spermatogenesis.	NA	NA	NA	PE1	15
+NX_Q86VS8	Protein Hook homolog 3	718	83126	5.12	0	Golgi apparatus;Cytosol;Centriolar satellite;Cytoskeleton	NA	Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).	NA	Belongs to the hook family.	NA	PE1	8
+NX_Q86VU5	Catechol O-methyltransferase domain-containing protein 1	262	28809	8.71	1	Membrane;Golgi apparatus;Cytosol;Cell membrane	NA	Putative O-methyltransferase.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.	NA	PE1	10
+NX_Q86VV4	Ran-binding protein 3-like	465	52211	9.15	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner.	NA	NA	NA	PE1	5
+NX_Q86VV8	Rotatin	2226	248630	6.25	0	Centrosome;Cilium basal body	Microcephaly, short stature, and polymicrogyria with or without seizures	Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2.	NA	NA	NA	PE1	18
+NX_Q86VW0	SEC14 domain and spectrin repeat-containing protein 1	696	79348	4.99	0	Cytoskeleton	NA	May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.	NA	Belongs to the SOLO family.	NA	PE1	2
+NX_Q86VW1	Solute carrier family 22 member 16	577	64614	8.44	12	Membrane;Cell membrane	NA	High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Organic cation transport	PE1	6
+NX_Q86VW2	Rho guanine nucleotide exchange factor 25	580	63843	6.19	0	Cytoplasmic vesicle;Sarcomere;Cell membrane	NA	May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).	NA	NA	G alpha (q) signalling events	PE1	12
+NX_Q86VX2	COMM domain-containing protein 7	200	22540	5.69	0	Cytoplasmic vesicle	NA	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).	NA	NA	Neddylation	PE1	20
+NX_Q86VX9	Vacuolar fusion protein MON1 homolog A	652	72895	8.43	0	Cytosol	NA	Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991).	NA	Belongs to the MON1/SAND family.	RAB GEFs exchange GTP for GDP on RABs	PE1	3
+NX_Q86VY4	Testis-specific Y-encoded-like protein 5	417	45143	9.57	0	Golgi apparatus;Cytosol	NA	Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	8
+NX_Q86VY9	Transmembrane protein 200A	491	54356	9.24	2	Membrane	NA	NA	NA	Belongs to the TMEM200 family.	NA	PE1	6
+NX_Q86VZ1	P2Y purinoceptor 8	359	40635	9.62	7	Cell membrane	NA	Probable receptor for purines coupled to G-proteins.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction	PE1	X
+NX_Q86VZ2	WD repeat-containing protein 5B	330	36338	7.53	0	NA	NA	May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.	NA	Belongs to the WD repeat WDR5/wds family.	NA	PE1	3
+NX_Q86VZ4	Low-density lipoprotein receptor-related protein 11	500	53311	6.04	1	Membrane;Mitochondrion	NA	NA	NA	Belongs to the LDLR family.	NA	PE1	6
+NX_Q86VZ5	Phosphatidylcholine:ceramide cholinephosphotransferase 1	413	48617	8.66	5	Golgi apparatus;Nucleolus;Nucleoplasm;Golgi apparatus membrane;Cytosol	NA	Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.	NA	Belongs to the sphingomyelin synthase family.	Sphingolipid metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis	PE1	10
+NX_Q86VZ6	Juxtaposed with another zinc finger protein 1	243	27079	8.63	0	Nucleoplasm;Nucleolus;Nucleus	NA	Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity).	NA	NA	NA	PE1	7
+NX_Q86W10	Cytochrome P450 4Z1	505	59086	9.29	1	Microsome membrane;Endoplasmic reticulum membrane	NA	NA	NA	Belongs to the cytochrome P450 family.	NA	PE1	1
+NX_Q86W11	Zinc finger and SCAN domain-containing protein 30	494	56364	6.24	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	18
+NX_Q86W24	NACHT, LRR and PYD domains-containing protein 14	1093	124733	6.18	0	Cytoplasm;Cytosol	NA	May be involved in inflammation and spermatogenesis.	NA	Belongs to the NLRP family.	NA	PE1	11
+NX_Q86W25	NACHT, LRR and PYD domains-containing protein 13	1043	118884	5.43	0	NA	NA	Involved in inflammation.	NA	Belongs to the NLRP family.	NA	PE1	19
+NX_Q86W26	NACHT, LRR and PYD domains-containing protein 10	655	75032	6.81	0	Nucleoplasm;Cytoplasm;Nucleus membrane;Cell membrane	NA	Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819).	NA	Belongs to the NLRP family.	NA	PE1	11
+NX_Q86W28	NACHT, LRR and PYD domains-containing protein 8	1048	119430	8.32	0	Cytoplasm	NA	Involved in inflammation.	NA	Belongs to the NLRP family.	NA	PE2	19
+NX_Q86W33	Transmembrane protein adipocyte-associated 1	373	41053	5.72	7	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the UPF0359 family.	NA	PE1	3
+NX_Q86W34	Archaemetzincin-2	360	41263	8.41	0	Nucleoplasm;Cytosol;Nucleus	NA	Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2.	NA	Belongs to the peptidase M54 family.	NA	PE1	17
+NX_Q86W42	THO complex subunit 6 homolog	341	37535	7.12	0	Nucleoplasm;Nucleus speckle;Nucleus	Beaulieu-Boycott-Innes syndrome	Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.	NA	Belongs to the WD repeat THOC6 family.	RNA transport;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	16
+NX_Q86W47	Calcium-activated potassium channel subunit beta-4	210	23949	6.29	2	Membrane;Cytosol	NA	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.	Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics.;N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin.	Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily.	Vascular smooth muscle contraction;Ca2+ activated K+ channels;cGMP effects	PE1	12
+NX_Q86W50	RNA N6-adenosine-methyltransferase METTL16	562	63621	8.08	0	Nucleoplasm;Cytosol;Nucleus	NA	RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200). Also able to bind various lncRNAs (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311).	NA	Belongs to the methyltransferase superfamily. METTL16/RlmF family.	NA	PE1	17
+NX_Q86W54	Spermatogenesis-associated protein 24	205	23587	7.77	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleolus	NA	Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity).	NA	Belongs to the SPATA24 family.	NA	PE1	5
+NX_Q86W56	Poly(ADP-ribose) glycohydrolase	976	111110	6.03	0	Cytoplasm;Mitochondrion;Mitochondrion matrix;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:21892188, PubMed:23102699, PubMed:23474714). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).	NA	Belongs to the poly(ADP-ribose) glycohydrolase family.	POLB-Dependent Long Patch Base Excision Repair	PE1	10
+NX_Q86W67	Protein FAM228A	206	23752	9.07	0	NA	NA	NA	NA	Belongs to the FAM228 family.	NA	PE2	2
+NX_Q86W74	Ankyrin repeat domain-containing protein 46	232	25967	6.65	1	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	8
+NX_Q86W92	Liprin-beta-1	1011	114024	5.4	0	Cytoplasm;Cytosol;Cell membrane	NA	May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.	NA	Belongs to the liprin family. Liprin-beta subfamily.	Receptor-type tyrosine-protein phosphatases	PE1	12
+NX_Q86WA6	Valacyclovir hydrolase	291	32543	9.2	0	Mitochondrion	NA	Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Phase I - Functionalization of compounds	PE1	6
+NX_Q86WA8	Lon protease homolog 2, peroxisomal	852	94617	6.88	0	Peroxisome matrix	NA	ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.	NA	Belongs to the peptidase S16 family.	Association of TriC/CCT with target proteins during biosynthesis;Peroxisomal protein import	PE1	16
+NX_Q86WA9	Sodium-independent sulfate anion transporter	606	65299	7.02	12	Golgi apparatus;Cell membrane;Lysosome membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC).	NA	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Multifunctional anion exchangers	PE1	17
+NX_Q86WB0	Nuclear-interacting partner of ALK	502	55262	5.44	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.	Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dependent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry.	NA	Protein modification; protein ubiquitination.	PE1	7
+NX_Q86WB7	Protein unc-93 homolog A	457	50270	7.46	11	Cell membrane	NA	NA	NA	Belongs to the unc-93 family.	NA	PE1	6
+NX_Q86WC4	Osteopetrosis-associated transmembrane protein 1	334	37257	5.69	1	Nucleoplasm;Cytosol;Lysosome membrane;Cytoplasmic vesicle	Osteopetrosis, autosomal recessive 5	Required for osteoclast and melanocyte maturation and function.	Highly N-glycosylated.;Undergoes proteolytic cleavage in the luminal domain, the cleaved fragments might be linked by disulfide bonds with the remnant of the protein.	Belongs to the OSTM1 family.	Stimuli-sensing channels	PE1	6
+NX_Q86WC6	Protein phosphatase 1 regulatory subunit 27	154	17438	6.51	0	NA	NA	Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.	NA	NA	NA	PE1	17
+NX_Q86WD7	Serpin A9	417	46557	9.58	0	Membrane;Cytoplasm;Secreted	NA	Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).	NA	Belongs to the serpin family.	NA	PE1	14
+NX_Q86WG3	Caytaxin	371	42120	4.54	0	Cytoplasm;Mitochondrion;Growth cone;Presynapse;Axon;Dendrite	Cerebellar ataxia, cayman type	Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites.	May be ubiquitinated by STUB1.;Cleaved by CASP3 and CASP7. The potential C-terminal product released by CASP3 cleavage may inhibit the ERK signaling pathway through MAP2K2.	NA	NA	PE1	19
+NX_Q86WG5	Myotubularin-related protein 13	1849	208464	6.62	0	Cytoplasm;Endosome membrane;Membrane;Nucleoplasm;Cytosol;Axon;Perinuclear region;Cytoskeleton	Charcot-Marie-Tooth disease 4B2	Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Synthesis of PIPs at the plasma membrane;RAB GEFs exchange GTP for GDP on RABs	PE1	11
+NX_Q86WH2	Ras association domain-containing protein 3	238	27562	7.02	0	Cytoplasm;Cytosol;Cell membrane;Cytoskeleton	NA	NA	NA	NA	NA	PE1	12
+NX_Q86WI0	LHFPL tetraspan subfamily member 1 protein	220	23777	8.39	3	Membrane	NA	NA	NA	Belongs to the LHFP family.	NA	PE2	X
+NX_Q86WI1	Fibrocystin-L	4243	465734	5.71	1	Membrane	NA	NA	NA	NA	NA	PE1	8
+NX_Q86WI3	Protein NLRC5	1866	204595	5.99	0	Cytoplasm;Centrosome	NA	Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.	NA	Belongs to the NLRP family.	DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling	PE1	16
+NX_Q86WJ1	Chromodomain-helicase-DNA-binding protein 1-like	897	101000	6.45	0	Nucleoplasm;Nucleus	NA	DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.	NA	Belongs to the SNF2/RAD54 helicase family.	Dual Incision in GG-NER;Formation of Incision Complex in GG-NER	PE1	1
+NX_Q86WK6	Amphoterin-induced protein 1	493	55239	6.22	1	Cell membrane;Perikaryon;Nucleoplasm;Axon;Dendrite;Nucleus	NA	Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.	NA	Belongs to the immunoglobulin superfamily. AMIGO family.	NA	PE1	1
+NX_Q86WK7	Amphoterin-induced protein 3	504	55250	8.11	1	Membrane	NA	May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).	NA	Belongs to the immunoglobulin superfamily. AMIGO family.	NA	PE1	3
+NX_Q86WK9	Membrane progestin receptor alpha	346	39719	6.99	7	Cytosol;Cell membrane	NA	Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).	NA	Belongs to the ADIPOR family.	NA	PE1	1
+NX_Q86WN1	F-BAR and double SH3 domains protein 1	690	76942	5.23	0	Cytoplasm;Perikaryon;Cell projection;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Promotes actin polymerization mediated by SNX9 and WASL.	NA	NA	NA	PE1	5
+NX_Q86WN2	Interferon epsilon	208	24414	8.75	0	Secreted	NA	Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;RIG-I-like receptor signaling pathway;Jak-STAT signaling pathway	PE2	9
+NX_Q86WP2	Vasculin	473	53339	6.56	0	Cytoplasm;Cell membrane;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Functions as a GC-rich promoter-specific transactivating transcription factor.	NA	Belongs to the vasculin family.	NA	PE1	5
+NX_Q86WQ0	Nuclear receptor 2C2-associated protein	139	15876	5.77	0	Nucleoplasm;Nucleus	NA	May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.	NA	Belongs to the NR2C2AP family.	Nuclear Receptor transcription pathway	PE1	19
+NX_Q86WR0	Coiled-coil domain-containing protein 25	208	24479	6.34	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the CCDC25 family.	NA	PE1	8
+NX_Q86WR6	Uncharacterized protein C17orf64	236	27182	9.65	0	Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	NA	NA	PE1	17
+NX_Q86WR7	Proline and serine-rich protein 2	435	45802	6.74	0	Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	10
+NX_Q86WS3	Oocyte-secreted protein 2	158	17971	4.71	0	Secreted	NA	NA	NA	Belongs to the PLAC1 family.	NA	PE1	11
+NX_Q86WS4	Uncharacterized protein C12orf40	652	74505	8.21	0	Golgi apparatus;Cytosol	NA	NA	NA	NA	NA	PE1	12
+NX_Q86WS5	Transmembrane protease serine 12	348	38605	8.91	1	Membrane	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE1	12
+NX_Q86WT1	Tetratricopeptide repeat protein 30A	665	76136	5.11	0	Cilium	NA	Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.	NA	Belongs to the TTC30/dfy-1/fleer family.	Intraflagellar transport	PE1	2
+NX_Q86WT6	E3 ubiquitin-protein ligase TRIM69	500	57419	6.04	0	Cytoplasm;Nucleus speckle;Nucleus	NA	May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.	Phosphorylated. Phosphorylation is necessary for nuclear localization.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	15
+NX_Q86WU2	Probable D-lactate dehydrogenase, mitochondrial	507	54871	6.2	0	Cytosol;Mitochondrion	D-lactic aciduria	Involved in D-lactate, but not L-lactate catabolic process.	NA	Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Pyruvate metabolism;Mitochondrial protein import	PE1	16
+NX_Q86WV1	Src kinase-associated phosphoprotein 1	359	41432	4.47	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.	Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB1. Tyr-232 is dephosphorylated by PTPRC (Probable).	Belongs to the SKAP family.	NA	PE1	17
+NX_Q86WV5	CST complex subunit TEN1	123	13856	7.76	0	Nucleoplasm;Telomere;Nucleus	NA	Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097).	NA	Belongs to the TEN1 family.	NA	PE1	17
+NX_Q86WV6	Stimulator of interferon genes protein	379	42193	6.6	4	Autophagosome membrane;Endoplasmic reticulum-Golgi intermediate compartment membrane;Mitochondrion outer membrane;Endoplasmic reticulum membrane;Cell membrane;Nucleoplasm;Cytosol;Perinuclear region	STING-associated vasculopathy, infantile-onset	(Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed:26405230). Such oncoproteins prevent the ability to sense cytosolic DNA (PubMed:26405230).;Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23910378, PubMed:23747010, PubMed:30842659). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed:26300263). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (PubMed:21947006, PubMed:23258412, PubMed:23707065, PubMed:23722158, PubMed:26229117, PubMed:23910378, PubMed:23747010, PubMed:30842659). Upon binding of c-di-GMP or cGAMP, TMEM173/STING oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state (PubMed:22394562, PubMed:25636800, PubMed:30842653). In addition to promote the production of type I interferons, plays a direct role in autophagy (PubMed:30568238, PubMed:30842662). Following cGAMP-binding, TMEM173/STING buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (PubMed:30842662). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (PubMed:30842662). The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (PubMed:30568238, PubMed:30842662). Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy (By similarity). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263, PubMed:23910378, PubMed:23747010). The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free-ligand conformation that resembles the TMEM173/STING-bound conformation and pays low energy costs in changing into the active conformation (PubMed:26150511). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons (PubMed:18724357). May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) (By similarity).	Ubiquitinated (PubMed:19285439, PubMed:19433799, PubMed:21074459, PubMed:25254379). Ubiquitinated via 'Lys-63'-linked ubiquitin chains in response to double-stranded DNA treatment, leading to relocalization to autophagosomes and subsequent degradation; this process is dependent on SQSTM1 (By similarity). 'Lys-63'-linked ubiquitination mediated by TRIM56 at Lys-150 promotes homodimerization and recruitment of the antiviral kinase TBK1 and subsequent production of IFN-beta (PubMed:21074459). 'Lys-48'-linked polyubiquitination at Lys-150 occurring after viral infection is mediated by RNF5 and leads to proteasomal degradation (PubMed:19285439). 'Lys-11'-linked polyubiquitination at Lys-150 by RNF26 leads to stabilize TMEM173/STING: it protects TMEM173/STING from RNF5-mediated 'Lys-48'-linked polyubiquitination (PubMed:25254379).;Phosphorylation by TBK1 leads to activation and production of IFN-beta (PubMed:18818105, PubMed:19433799, PubMed:25636800, PubMed:30842659, PubMed:30842653, PubMed:27302953). Following cyclic nucleotide (c-di-GMP or cGAMP)-binding, activation and translocation from the endoplasmic reticulum, TMEM173/STING is phosphorylated by TBK1 at Ser-366 in the pLxIS motif (PubMed:25636800). The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines (PubMed:25636800). Phosphorylated on tyrosine residues upon MHC-II aggregation (By similarity).	Belongs to the TMEM173 family.	RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;STING mediated induction of host immune responses;Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN;STAT6-mediated induction of chemokines;Neutrophil degranulation	PE1	5
+NX_Q86WW8	Cytochrome c oxidase assembly factor 5	74	8376	8.97	0	Mitochondrion	Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3	Involved in an early step of the mitochondrial complex IV assembly process.	NA	Belongs to the PET191 family.	NA	PE1	2
+NX_Q86WX3	Active regulator of SIRT1	136	15434	10.75	0	Nucleoplasm;Nucleolus;Nucleus;Cytosol	NA	Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.	Citrullinated by PADI4.	Belongs to the AROS family.	Regulation of HSF1-mediated heat shock response	PE1	22
+NX_Q86WZ0	HEAT repeat-containing protein 4	1026	117175	9.21	0	NA	NA	NA	NA	NA	NA	PE1	14
+NX_Q86WZ6	Zinc finger protein 227	799	92033	9.1	0	Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q86X02	Cerebellar degeneration-related protein 2-like	465	53010	5.7	0	Cytosol	NA	NA	NA	Belongs to the CDR2 family.	NA	PE1	17
+NX_Q86X10	Ral GTPase-activating protein subunit beta	1494	166799	6.33	0	Nucleus speckle	NA	Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.	NA	NA	Translocation of SLC2A4 (GLUT4) to the plasma membrane	PE1	20
+NX_Q86X19	Transmembrane protein 17	198	23046	6.3	4	Cilium membrane;Cytoskeleton	NA	Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).	NA	Belongs to the TMEM17 family.	NA	PE1	2
+NX_Q86X24	HORMA domain-containing protein 1	394	45200	5.66	0	Nucleoplasm;Nucleolus;Nucleus;Chromosome	NA	Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.	Phosphorylated at Ser-377 in a SPO11-dependent manner.	NA	NA	PE1	1
+NX_Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	583	65167	8.86	0	Nucleoplasm;Cytoplasm;Cytosol;Cell membrane	NA	Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity).	NA	NA	NA	PE1	1
+NX_Q86X29	Lipolysis-stimulated lipoprotein receptor	649	71439	8.29	1	Nucleoplasm;Cytosol;Cell membrane	NA	Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).	NA	Belongs to the immunoglobulin superfamily. LISCH7 family.	LDL clearance;VLDL clearance	PE1	19
+NX_Q86X40	Leucine-rich repeat-containing protein 28	367	41912	8.18	0	Golgi apparatus;Nucleoplasm;Mitochondrion	NA	NA	NA	NA	NA	PE1	15
+NX_Q86X45	Protein tilB homolog	466	54255	6.08	0	Cytoplasm;Cilium	Ciliary dyskinesia, primary, 19	May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility.	NA	Belongs to the tilB family.	NA	PE1	8
+NX_Q86X51	EZH inhibitory protein	503	51894	10.15	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Inhibits PRC2/EED-EZH2 complex function thereby causing down-regulation of H3K27me3. In the PRC2/EED-EZH2 complex, interacts and inhibits EZH2 methyltransferase activity.	NA	NA	NA	PE1	X
+NX_Q86X52	Chondroitin sulfate synthase 1	802	91784	9.31	1	Golgi stack membrane;Secreted	Temtamy preaxial brachydactyly syndrome	Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.	NA	Belongs to the chondroitin N-acetylgalactosaminyltransferase family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Metabolic pathways;Chondroitin sulfate biosynthesis;Defective CHSY1 causes TPBS	PE1	15
+NX_Q86X53	Glutamate-rich protein 1	443	48984	4.68	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	8
+NX_Q86X55	Histone-arginine methyltransferase CARM1	608	65854	6.25	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.	Auto-methylated on Arg-550. Methylation enhances transcription coactivator activity. Methylation is required for its role in the regulation of pre-mRNA alternative splicing (By similarity).;Phosphorylation at Ser-216 interferes with S-adenosyl-L-methionine binding and strongly reduces methyltransferase activity (By similarity). Phosphorylation at Ser-216 is strongly increased during mitosis, and decreases rapidly to a very low, basal level after entry into the G1 phase of the cell cycle. Phosphorylation at Ser-216 may promote location in the cytosol.	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	RMTs methylate histone arginines;PPARA activates gene expression;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Estrogen-dependent gene expression	PE1	19
+NX_Q86X59	Putative uncharacterized protein C17orf82	251	25393	10.38	0	NA	NA	NA	NA	NA	NA	PE1	17
+NX_Q86X60	Protein FAM72B	149	16617	5.54	0	NA	NA	NA	NA	Belongs to the FAM72 family.	NA	PE2	1
+NX_Q86X67	Nucleoside diphosphate-linked moiety X motif 13	352	39688	7.11	0	Nucleoplasm	NA	NA	NA	NA	Interconversion of nucleotide di- and triphosphates	PE2	10
+NX_Q86X76	Deaminated glutathione amidase	327	35896	7.91	0	Cytoplasm;Mitochondrion	NA	Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.	NA	Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.	NA	PE1	1
+NX_Q86X83	COMM domain-containing protein 2	199	22745	6.24	0	Cytoplasm;Nucleoplasm;Nucleus	NA	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).	NA	NA	Neddylation	PE1	3
+NX_Q86X95	Corepressor interacting with RBPJ 1	450	52313	9.88	0	Nucleus speckle;Centrosome	NA	May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.	Phosphorylated by NEK6.;CIR1 is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Notch signaling pathway	PE1	2
+NX_Q86XA0	Methyltransferase-like protein 23	190	21469	4.91	1	Membrane;Cytoplasm;Cytoplasmic vesicle	Mental retardation, autosomal recessive 44	Probable methyltransferase.	NA	Belongs to the methyltransferase superfamily. METTL23 family.	NA	PE1	17
+NX_Q86XA9	HEAT repeat-containing protein 5A	2040	222004	6.14	0	NA	NA	NA	NA	Belongs to the HEATR5 family.	NA	PE1	14
+NX_Q86XD5	Protein FAM131B	332	35769	4.34	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the FAM131 family.	Signaling by BRAF and RAF fusions	PE1	7
+NX_Q86XD8	AN1-type zinc finger protein 4	727	80358	8.66	0	Golgi apparatus	NA	NA	NA	NA	NA	PE2	10
+NX_Q86XE0	Sorting nexin-32	403	46399	6.63	0	Cell junction;Focal adhesion	NA	May be involved in several stages of intracellular trafficking.	NA	Belongs to the sorting nexin family.	NA	PE1	11
+NX_Q86XE3	Calcium uptake protein 3, mitochondrial	530	60711	8.35	1	Membrane;Mitochondrion	NA	May play a role in mitochondrial calcium uptake.	NA	Belongs to the MICU1 family. MICU3 subfamily.	Processing of SMDT1;Mitochondrial calcium ion transport	PE1	8
+NX_Q86XE5	4-hydroxy-2-oxoglutarate aldolase, mitochondrial	327	35249	8.13	0	Mitochondrion	Hyperoxaluria primary 3	Catalyzes the final step in the metabolic pathway of hydroxyproline.	NA	Belongs to the DapA family.	Glyoxylate metabolism and glycine degradation	PE1	10
+NX_Q86XF0	Dihydrofolate reductase 2, mitochondrial	187	21620	7.75	0	Mitochondrion matrix;Mitochondrion inner membrane;Mitochondrion	NA	Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.	NA	Belongs to the dihydrofolate reductase family.	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.;Metabolism of folate and pterines	PE1	3
+NX_Q86XF7	Zinc finger protein 575	245	26763	9.83	0	Nucleoplasm;Nucleus;Nucleolus;Cytosol	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q86XG9	Putative neuroblastoma breakpoint family member 5	351	40546	4.95	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE5	1
+NX_Q86XH1	Dynein regulatory complex protein 11	822	95341	9.48	0	Flagellum axoneme;Nucleoplasm	NA	Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.	NA	Belongs to the AAA ATPase family. DRC11 subfamily.	NA	PE1	2
+NX_Q86XI2	Condensin-2 complex subunit G2	1143	130960	6.43	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.	NA	NA	Condensation of Prophase Chromosomes	PE1	7
+NX_Q86XI6	Protein phosphatase 1 regulatory subunit 3B	285	32695	5.86	0	Cytosol	NA	Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity).	NA	NA	Insulin signaling pathway	PE1	8
+NX_Q86XI8	Uncharacterized protein ZSWIM9	627	70073	8.92	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q86XJ0	Calcium homeostasis modulator protein 3	344	38496	8.98	4	Membrane;Nucleoplasm	NA	Pore-forming subunit of a voltage-gated ion channel.	NA	Belongs to the CALHM family.	NA	PE1	10
+NX_Q86XJ1	GAS2-like protein 3	694	75214	9.67	0	Cytoplasm;Cytoskeleton	NA	Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network.	NA	Belongs to the GAS2 family.	NA	PE1	12
+NX_Q86XK2	F-box only protein 11	927	103585	6.53	0	Nucleoplasm;Nucleus;Chromosome	Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	2
+NX_Q86XK3	Swi5-dependent recombination DNA repair protein 1 homolog	245	28262	6.06	0	Nucleus	NA	Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500).	NA	Belongs to the SFR1/MEI5 family.	NA	PE1	10
+NX_Q86XK7	V-set and immunoglobulin domain-containing protein 1	387	41811	4.59	1	Membrane;Cytoplasmic vesicle;Cytosol	NA	NA	Highly N-glycosylated. Appears not to contain significant amounts of O-linked carbohydrates or sialic acid in its sugar moieties.	NA	NA	PE1	X
+NX_Q86XL3	Ankyrin repeat and LEM domain-containing protein 2	938	104114	6.66	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Cell membrane	Microcephaly 16, primary, autosomal recessive	Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development (PubMed:25259927).	NA	Belongs to the ANKLE2 family.	Initiation of Nuclear Envelope Reformation	PE1	12
+NX_Q86XM0	Cation channel sperm-associated protein subunit delta	798	90468	7.04	1	Flagellum membrane	NA	Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.	NA	Belongs to the CATSPERD family.	Sperm Motility And Taxes	PE1	19
+NX_Q86XN6	Zinc finger protein 761	746	87716	9.22	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q86XN7	Proline and serine-rich protein 1	944	95698	9.06	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	13
+NX_Q86XN8	RNA-binding protein MEX3D	651	64883	5.19	0	Cytoplasm;Nucleus	NA	RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.	Phosphorylated.	NA	NA	PE1	19
+NX_Q86XP0	Cytosolic phospholipase A2 delta	818	91952	5.33	0	Membrane;Cytosol	NA	Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). Has a preference for linoleic acid at the sn-2 position (PubMed:14709560).	NA	NA	Lipid metabolism; fatty acid metabolism.;Fc gamma R-mediated phagocytosis;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC	PE1	15
+NX_Q86XP1	Diacylglycerol kinase eta	1220	134866	6.11	0	Cytoplasm;Cell membrane	NA	Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.	Phosphorylated; does not inhibit catalytic activity.	Belongs to the eukaryotic diacylglycerol kinase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Effects of PIP2 hydrolysis	PE1	13
+NX_Q86XP3	ATP-dependent RNA helicase DDX42	938	102975	6.54	0	Cajal body;Cytoplasm;Nucleus speckle	NA	ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.	NA	Belongs to the DEAD box helicase family. DDX42 subfamily.	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	17
+NX_Q86XP6	Gastrokine-2	184	20487	7.03	0	Secreted	NA	NA	NA	NA	NA	PE1	2
+NX_Q86XQ3	Cation channel sperm-associated protein 3	398	46422	5.88	6	Flagellum membrane	NA	Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.	NA	Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.	Sperm Motility And Taxes	PE1	5
+NX_Q86XR2	Protein Niban 3	697	77413	8.99	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the Niban family.	NA	PE1	19
+NX_Q86XR5	Proline-rich membrane anchor 1	153	16689	8.83	1	Cell membrane;Cell junction;Nucleolus;Synapse;Cytosol	NA	Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity).	NA	NA	NA	PE1	14
+NX_Q86XR7	TIR domain-containing adapter molecule 2	235	26916	4.99	0	Golgi apparatus;Cytoplasm;Cell membrane;Endoplasmic reticulum;Phagocytic cup;Early endosome membrane;Late endosome membrane	NA	Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.;Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606).	Is myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.;Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation. Tyrosine phosphorylation is inhibited by phosphatase PTPN4.	NA	Toll-like receptor signaling pathway;Pertussis;Toll Like Receptor 4 (TLR4) Cascade;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;Caspase activation via Death Receptors in the presence of ligand;MyD88-independent TLR4 cascade;TRIF-mediated programmed cell death;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Neutrophil degranulation	PE1	5
+NX_Q86XR8	Centrosomal protein of 57 kDa	500	57089	9.35	0	Cytoplasm;Centrosome;Cytosol;Nucleus;Cytoskeleton	Mosaic variegated aneuploidy syndrome 2	Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.	NA	Belongs to the translokin family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	11
+NX_Q86XS5	Angiopoietin-related protein 5	388	44144	6.14	0	Secreted	NA	NA	NA	NA	NA	PE1	11
+NX_Q86XS8	E3 ubiquitin-protein ligase RNF130	419	46405	9.12	1	Membrane;Cytoplasm	NA	May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase.	In vivo measurements suggest this protein is glycosylated (PubMed:19159218). In contrast, in vitro experiments failed to detect glycosylation (PubMed:16549277).	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	5
+NX_Q86XT2	Vacuolar protein sorting-associated protein 37D	251	27730	9.2	0	Cytoplasmic vesicle;Late endosome membrane	NA	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.	NA	Belongs to the VPS37 family.	Endocytosis;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	7
+NX_Q86XT4	E3 ubiquitin-protein ligase TRIM50	487	54774	7.28	0	Cytoplasm	NA	E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.	Auto-ubiquitinated.;Acetylated by EP300 and KAT2B. HDAC6 drives TRIM50 deacetylation. Acetylation antagonizes with TRIM50 ubiquitination.	Belongs to the TRIM/RBCC family.	Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	7
+NX_Q86XT9	Insulin-like growth factor-binding protein 3 receptor	240	25724	8.81	1	Cell membrane	NA	Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.	NA	NA	TP53 Regulates Transcription of Death Receptors and Ligands	PE1	16
+NX_Q86XU0	Zinc finger protein 677	584	67996	9.3	0	Nucleoplasm;Centrosome;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q86XW9	Thioredoxin domain-containing protein 6	330	36856	4.82	0	Cytoplasm;Cytoskeleton	NA	May be a regulator of microtubule physiology.	NA	Belongs to the NDK family.	NA	PE1	3
+NX_Q86XX4	Extracellular matrix protein FRAS1	4008	443214	5.32	1	Cell membrane	Fraser syndrome 1	NA	NA	Belongs to the FRAS1 family.	NA	PE1	4
+NX_Q86XZ4	Spermatogenesis-associated serine-rich protein 2	545	59545	9.01	0	Cytoplasm;Cytosol	NA	NA	NA	Belongs to the SPATS2 family.	NA	PE1	12
+NX_Q86Y01	E3 ubiquitin-protein ligase DTX1	620	67368	9.67	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.	Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH.	Belongs to the Deltex family.	Protein modification; protein ubiquitination.;Notch signaling pathway;Activated NOTCH1 Transmits Signal to the Nucleus	PE1	12
+NX_Q86Y07	Serine/threonine-protein kinase VRK2	508	58141	8.97	1	Cytoplasm;Endoplasmic reticulum membrane;Endoplasmic reticulum;Nucleus envelope;Mitochondrion membrane;Nucleus	NA	Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.;Serine/threonine kinase that regulates several signal transduction pathways.;Modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.	Are autophosphorylated.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);VRK2 is phosphorylated by PLK3	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.	Initiation of Nuclear Envelope Reformation;Nuclear Envelope Breakdown	PE1	2
+NX_Q86Y13	E3 ubiquitin-protein ligase DZIP3	1208	138604	6.45	0	Cytoplasm;Cytoplasmic vesicle	NA	E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	3
+NX_Q86Y22	Collagen alpha-1(XXIII) chain	540	51944	6.88	1	Cell membrane	NA	NA	Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin.	NA	Collagen degradation;Collagen biosynthesis and modifying enzymes;Integrin cell surface interactions;Collagen chain trimerization	PE1	5
+NX_Q86Y25	Zinc finger protein 354C	554	64847	8.36	0	Cytosol;Nucleus membrane;Nucleus	NA	May function as a transcription repressor. Binds to 5'-CCACA-3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	5
+NX_Q86Y26	NUT family member 1	1132	120314	5.32	0	Cytoplasm;Nucleus	NA	Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.	Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.;Methylated at Gln-1046 by N6AMT1.	Belongs to the NUT family.	NA	PE1	15
+NX_Q86Y27	B melanoma antigen 5	43	4711	4.58	0	Secreted	NA	Unknown. Candidate gene encoding tumor antigens.	NA	Belongs to the BAGE family.	NA	PE2	13
+NX_Q86Y28	B melanoma antigen 4	39	4230	4.25	0	Secreted	NA	Unknown. Candidate gene encoding tumor antigens.	NA	Belongs to the BAGE family.	NA	PE2	21
+NX_Q86Y29	B melanoma antigen 3	109	12112	8.59	0	Secreted	NA	Unknown. Candidate gene encoding tumor antigens.	NA	Belongs to the BAGE family.	NA	PE2	21
+NX_Q86Y30	B melanoma antigen 2	109	12114	9.02	0	Secreted	NA	Unknown. Candidate gene encoding tumor antigens.	NA	Belongs to the BAGE family.	NA	PE2	21
+NX_Q86Y33	Cell division cycle protein 20 homolog B	519	57335	8.76	0	NA	NA	NA	NA	Belongs to the WD repeat CDC20/Fizzy family.	NA	PE1	5
+NX_Q86Y34	Adhesion G protein-coupled receptor G3	549	60861	9.01	7	Cell membrane	NA	Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658).	NA	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	Neutrophil degranulation	PE1	16
+NX_Q86Y37	CDK2-associated and cullin domain-containing protein 1	369	41064	5.08	0	Nucleoplasm	NA	Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.	NA	Belongs to the cullin family.	NA	PE1	10
+NX_Q86Y38	Xylosyltransferase 1	959	107569	9.32	1	Endoplasmic reticulum;Secreted;Cell membrane;Golgi apparatus membrane	Desbuquois dysplasia 2;Pseudoxanthoma elasticum	Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (PubMed:15461586, PubMed:17189265, PubMed:24581741, PubMed:23982343). Required for normal embryonic and postnatal skeleton development, especially of the long bones (PubMed:24581741, PubMed:23982343). Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity).	N-glycosylated.;Contains 7 disulfide bonds.	Belongs to the glycosyltransferase 14 family. XylT subfamily.	Glycan metabolism; chondroitin sulfate biosynthesis.;Glycan metabolism; heparan sulfate biosynthesis.;Glycosaminoglycan biosynthesis - chondroitin sulfate;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;A tetrasaccharide linker sequence is required for GAG synthesis	PE1	16
+NX_Q86Y39	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	141	14852	8.95	2	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 14	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFA11 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	19
+NX_Q86Y46	Keratin, type II cytoskeletal 73	540	58923	6.93	0	NA	NA	Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q86Y56	Dynein assembly factor 5, axonemal	855	93521	5.98	0	Nucleoplasm;Cytoplasm;Cytosol;Cytoplasmic granule	Ciliary dyskinesia, primary, 18	Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility.	NA	Belongs to the DNAAF5 family.	NA	PE1	7
+NX_Q86Y78	Ly6/PLAUR domain-containing protein 6	171	19118	5.69	0	Cytoplasm;Cell membrane;Synaptosome;Secreted;Cytosol;Membrane raft	NA	Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).	NA	NA	NA	PE1	2
+NX_Q86Y79	Probable peptidyl-tRNA hydrolase	214	22937	10.59	0	NA	NA	NA	NA	Belongs to the PTH family.	NA	PE1	9
+NX_Q86Y82	Syntaxin-12	276	31642	5.45	1	Golgi apparatus;Endosome membrane;Endomembrane system;Nucleoplasm;Recycling endosome membrane;Golgi apparatus membrane;Early endosome membrane;Cytoplasmic vesicle	NA	SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	NA	Belongs to the syntaxin family.	Phagosome	PE1	1
+NX_Q86Y91	Kinesin-like protein KIF18B	852	93011	8.89	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	17
+NX_Q86Y97	Histone-lysine N-methyltransferase KMT5C	462	52113	9.9	0	Nucleoplasm;Nucleus;Chromosome	NA	Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.	Lysine degradation;PKMTs methylate histone lysines	PE1	19
+NX_Q86YA3	Protein ZGRF1	2104	236602	5.81	1	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	4
+NX_Q86YB7	Enoyl-CoA hydratase domain-containing protein 2, mitochondrial	292	31126	9.03	0	Mitochondrion	NA	NA	NA	Belongs to the enoyl-CoA hydratase/isomerase family.	NA	PE1	1
+NX_Q86YB8	ERO1-like protein beta	467	53543	8.25	0	Endoplasmic reticulum membrane	NA	Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.	N-glycosylated.;The Cys-90/Cys-95 and Cys-393/Cys-396 disulfide bonds constitute the redox-active center. The Cys-90/Cys-95 disulfide bond accepts electron from P4HB and funnel them to the active site disulfide Cys-393/Cys-396. The Cys-81/Cys-390 disulfide bond may be critical for structural stability. Two long-range disulfide bonds participate in loose feedback regulation. The Cys-90/Cys-130 disulfide bond may be the predominant regulatory switch to modulate the catalytic activity, while the Cys-100/Cys-262 disulfide bond may play an auxiliary regulatory role.	Belongs to the EROs family.	Protein processing in endoplasmic reticulum;Insulin processing	PE1	1
+NX_Q86YC2	Partner and localizer of BRCA2	1186	131295	6.03	0	Nucleoplasm;Nucleus	Breast cancer;Fanconi anemia complementation group N;Pancreatic cancer 3	Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19423707, PubMed:19369211, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656).	PALB2 is phosphorylated by ATR (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Fanconi anemia pathway;HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange	PE1	16
+NX_Q86YC3	Transforming growth factor beta activator LRRC33	692	76366	5.75	1	Endoplasmic reticulum membrane;Cell membrane	NA	Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 (By similarity). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (By similarity). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (PubMed:23545260).	NA	Belongs to the LRRC32/LRRC33 family.	NA	PE1	3
+NX_Q86YD1	Prostate tumor-overexpressed gene 1 protein	416	46869	10.54	0	Nucleoplasm;Perinuclear region;Nucleus;Cell membrane	NA	May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.	NA	Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.	NA	PE1	19
+NX_Q86YD3	Transmembrane protein 25	366	39285	7.06	1	Golgi apparatus;Cytoplasmic vesicle;Secreted;Cell membrane	NA	NA	NA	NA	NA	PE1	11
+NX_Q86YD5	Low-density lipoprotein receptor class A domain-containing protein 3	345	37419	4.74	1	Cell junction;Cell membrane	NA	May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.	NA	Belongs to the LDLR family.	NA	PE1	11
+NX_Q86YD7	Protein FAM90A1	464	49793	9.71	0	NA	NA	NA	NA	Belongs to the FAM90 family.	NA	PE1	12
+NX_Q86YE8	Zinc finger protein 573	665	78181	9.32	0	Cytosol;Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q86YF9	Zinc finger protein DZIP1	867	98664	5.8	0	Cytoplasm;Centriole;Centriolar satellite;Cilium basal body;Nucleoplasm;Cytosol;Nucleus	NA	May participate in spermatogenesis via its interaction with DAZ (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954).	NA	Belongs to the DZIP C2H2-type zinc-finger protein family.	Hedgehog 'on' state	PE1	13
+NX_Q86YG4	5'-nucleotidase domain-containing protein 4	428	48951	5.68	0	NA	NA	NA	NA	Belongs to the 5'(3')-deoxyribonucleotidase family.	NA	PE1	2
+NX_Q86YH2	Zinc finger protein 280B	543	61584	7.62	0	Nucleoplasm;Nucleus	NA	May function as a transcription factor.	NA	NA	NA	PE1	22
+NX_Q86YH6	Decaprenyl-diphosphate synthase subunit 2	399	44129	8.43	0	Cytosol;Mitochondrion	Coenzyme Q10 deficiency, primary, 3	Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.	NA	Belongs to the FPP/GGPP synthase family.	Cofactor biosynthesis; ubiquinone biosynthesis.;Terpenoid backbone biosynthesis;Ubiquinol biosynthesis	PE1	6
+NX_Q86YI8	PHD finger protein 13	300	33582	7.89	0	Nucleoplasm;Nucleus	NA	Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.	Subject to proteasomal degradation. Stable when bound to chromatin. The soluble form is rapidly degraded.	NA	NA	PE1	1
+NX_Q86YJ5	E3 ubiquitin-protein ligase MARCH9	346	37772	9.36	2	Lysosome membrane;Golgi apparatus membrane	NA	E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.	NA	NA	Protein modification; protein ubiquitination.	PE1	12
+NX_Q86YJ6	Threonine synthase-like 2	484	54116	6.07	0	Secreted	NA	Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.;Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).	NA	Belongs to the threonine synthase family.	NA	PE1	2
+NX_Q86YJ7	Ankyrin repeat domain-containing protein 13B	626	70205	6.47	0	Cytoplasmic vesicle;Early endosome;Late endosome;Cell membrane	NA	Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	NA	NA	NA	PE1	17
+NX_Q86YL5	Testis development-related protein	185	20403	5.76	0	Cytoplasm;Cytosol;Nucleus;Cytoplasmic vesicle	NA	Contributes to normal sperm motility, but not essential for male fertility.	NA	Belongs to the TDRP family.	NA	PE1	8
+NX_Q86YL7	Podoplanin	162	16698	4.37	1	Filopodium membrane;Invadopodium;Apical cell membrane;Basolateral cell membrane;Microvillus membrane;Lamellipodium membrane;Membrane;Ruffle membrane;Cytoplasmic vesicle;Cytosol;Membrane raft	NA	Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:18215137, PubMed:17222411). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed:18541721). Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness (PubMed:17046996, PubMed:21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed:20962267). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate to connection of the lymphatic endothelium to the surrounding extracellular matrix (PubMed:19268462). In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion (PubMed:15515019). Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (PubMed:25486435). Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels (PubMed:9651190). Does not have any effect on folic acid or amino acid transport (By similarity).	The N-terminus is blocked.;Cleaved by a metalloprotease within its extracellular (EC) domain, generating a membrane-bound C-terminal fragment (PCTF33) and an extracellular fragment. The resulting membrane-bound C-terminal fragment (PCTF33) is further processed between Val-150 and Val-151 by PSEN1/gamma-secretase generating the intracellular domain of podoplanin (PICD).;Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity. Disialylated at Thr-52; sialic acid is critical for platelet-aggregating activity and for CLEC1B interaction (PubMed:17222411, PubMed:25458834).	Belongs to the podoplanin family.	GPVI-mediated activation cascade	PE1	1
+NX_Q86YM7	Homer protein homolog 1	354	40277	5.33	0	Cytoplasm;Dendritic spine;Postsynaptic density;Synapse;Cytosol	NA	Regulates the trafficking and surface expression of GRM5.;Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2.;May be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).;Acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function.	NA	Belongs to the Homer family.	Glutamatergic synapse;Neurexins and neuroligins	PE1	5
+NX_Q86YN1	Dolichyldiphosphatase 1	238	27031	9.48	4	Cytoplasmic vesicle;Endoplasmic reticulum membrane;Cytoskeleton	NA	Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).	NA	Belongs to the dolichyldiphosphatase family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Synthesis of Dolichyl-phosphate	PE1	9
+NX_Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	1023	113222	4.94	0	Nucleoplasm;Nucleus	NA	Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.	PPARGC1B is phosphorylated by SRPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	PPARA activates gene expression;Transcriptional activation of mitochondrial biogenesis;Regulation of RUNX2 expression and activity	PE1	5
+NX_Q86YP4	Transcriptional repressor p66-alpha	633	68063	9.95	0	Nucleoplasm;Nucleus speckle	NA	Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.	NA	NA	RNA Polymerase I Transcription Initiation;HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;Regulation of PTEN gene transcription	PE1	19
+NX_Q86YQ2	Putative BPIFA4P protein	179	19456	5.33	0	Secreted	NA	Major protein in sweat, has surfactant properties.	NA	Belongs to the BPI/LBP/Plunc superfamily. Plunc family.	NA	PE5	20
+NX_Q86YQ8	Copine-8	564	63108	5.66	0	NA	NA	Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.	NA	Belongs to the copine family.	NA	PE1	12
+NX_Q86YR5	G-protein-signaling modulator 1	675	74510	6.1	0	Golgi apparatus;Endoplasmic reticulum membrane;Cell membrane;Nucleoplasm;Golgi apparatus membrane;Cytosol	NA	Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.	Phosphorylation regulates interaction with G(i/o) alpha.	Belongs to the GPSM family.	G alpha (i) signalling events	PE1	9
+NX_Q86YR6	POTE ankyrin domain family member D	584	66394	6.32	0	Cell membrane	NA	NA	NA	Belongs to the POTE family.	NA	PE1	21
+NX_Q86YR7	Probable guanine nucleotide exchange factor MCF2L2	1114	126993	6	0	Cytosol;Cell membrane	Diabetes mellitus, non-insulin-dependent	Probably functions as a guanine nucleotide exchange factor.	NA	Belongs to the MCF2 family.	NA	PE1	3
+NX_Q86YS3	Rab11 family-interacting protein 4	637	71928	4.78	0	Cleavage furrow;Endosome;Centrosome;Recycling endosome membrane;Cytoplasmic vesicle;Spindle;Midbody	NA	Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.	NA	NA	Endocytosis	PE1	17
+NX_Q86YS6	Ras-related protein Rab-43	212	23339	5.44	0	trans-Golgi network;Golgi apparatus;Cell membrane;Phagosome membrane;trans-Golgi network membrane;Phagosome	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.	NA	Belongs to the small GTPase superfamily. Rab family.	Retrograde transport at the Trans-Golgi-Network;RAB geranylgeranylation	PE1	3
+NX_Q86YS7	C2 domain-containing protein 5	1000	110447	5.47	0	Cell cortex;Cell membrane;Centriolar satellite;Cytoplasmic vesicle membrane;Ruffle;Cytosol	NA	Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.	Phosphorylated on Ser-197 by active myristoylated kinase AKT2; insulin-stimulated phosphorylation by AKT2 regulates SLC2A4/GLUT4 translocation into the plasma membrane.	NA	Translocation of SLC2A4 (GLUT4) to the plasma membrane	PE1	12
+NX_Q86YT5	Solute carrier family 13 member 5	568	63062	8.52	12	Membrane;Nucleoplasm;Cytosol;Cell membrane	Epileptic encephalopathy, early infantile, 25, with amelogenesis imperfecta	High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.	NA	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.	Sodium-coupled sulphate, di- and tri-carboxylate transporters	PE1	17
+NX_Q86YT6	E3 ubiquitin-protein ligase MIB1	1006	110136	6.47	0	Cytoplasmic vesicle;Cytoplasm;Centriolar satellite;Cell membrane	Left ventricular non-compaction 7	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.	Ubiquitinated; possibly via autoubiquitination (By similarity). Ubiquitinated; this modification is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.	NA	Protein modification; protein ubiquitination.;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus	PE1	18
+NX_Q86YT9	Junctional adhesion molecule-like	394	44339	6.68	1	Cell junction;Cell membrane	NA	Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.	NA	Belongs to the immunoglobulin superfamily.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall	PE1	11
+NX_Q86YV0	RAS protein activator like-3	1011	111898	9.03	0	Cytoplasm;Nucleoplasm;Cell cortex;Cell membrane	NA	Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway.	NA	NA	Regulation of RAS by GAPs;Signaling by RAS mutants	PE1	19
+NX_Q86YV5	Inactive tyrosine-protein kinase PRAG1	1406	149624	6.83	0	Cytoplasm;Focal adhesion;Nucleus	NA	Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity).	Phosphorylated by CSK on Tyr-253, Tyr-365, and Tyr-413; Tyr-413 is a primary site of phosphorylation.	Belongs to the protein kinase superfamily.	NA	PE1	8
+NX_Q86YV6	Myosin light chain kinase family member 4	388	44508	5.89	0	Golgi apparatus;Nucleolus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	6
+NX_Q86YV9	Hermansky-Pudlak syndrome 6 protein	775	82975	5.92	0	Early endosome membrane;Microsome membrane;Cytosol;Lysosome membrane	Hermansky-Pudlak syndrome 6	May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (PubMed:17041891). Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning (PubMed:25189619).	NA	NA	NA	PE1	10
+NX_Q86YW0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	608	70411	9.14	0	Perinuclear region;Nucleus	Spermatogenic failure 17	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Phosphatidylinositol signaling system;Oocyte meiosis;Synthesis of IP3 and IP4 in the cytosol	PE1	12
+NX_Q86YW5	Trem-like transcript 1 protein	311	32679	5.7	1	Cytoplasm;Cell membrane	NA	Cell surface receptor that may play a role in the innate and adaptive immune response.	Phosphorylated on tyrosine residues.	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	6
+NX_Q86YW7	Glycoprotein hormone beta-5	130	14232	8	0	Secreted	NA	Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.	N-glycosylated.	Belongs to the glycoprotein hormones subunit beta family.	G alpha (s) signalling events;Hormone ligand-binding receptors	PE1	14
+NX_Q86YW9	Mediator of RNA polymerase II transcription subunit 12-like protein	2145	240120	7.97	0	Nucleolus;Nucleus	NA	May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).	NA	Belongs to the Mediator complex subunit 12 family.	NA	PE1	3
+NX_Q86YZ3	Hornerin	2850	282390	10.05	0	Cytoplasmic granule;Mitochondrion	NA	Component of the epidermal cornified cell envelopes.	Processed during the process of epidermal differentiation.;Forms covalent cross-links mediated by transglutaminase TGM3, between glutamine and the epsilon-amino group of lysine residues (in vitro).	In the N-terminal section; belongs to the S-100 family.;Belongs to the S100-fused protein family.	Neutrophil degranulation	PE1	1
+NX_Q86Z02	Homeodomain-interacting protein kinase 1	1210	130843	8.48	0	Cytoplasm;Nucleus speckle;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171).	Degraded by PARK7 at the protein level.;Autophosphorylated. Phosphorylated and activated by JNK1.;Sumoylated. When conjugated it is directed to nuclear speckles. SENP1-mediated desumoylation is mediated by TNF in response to stress stimuli, triggering transient translocation from nucleus to cytoplasm.;HIPK1 is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.	YAP1- and WWTR1 (TAZ)-stimulated gene expression;Physiological factors;Regulation of TP53 Activity through Phosphorylation	PE1	1
+NX_Q86Z14	Beta-klotho	1044	119808	9.28	1	Cell membrane	NA	Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).	NA	Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.	RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade, FGFR4;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR4 signaling;betaKlotho-mediated ligand binding;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	4
+NX_Q86Z20	Coiled-coil domain-containing protein 125	511	58629	6.86	0	Cytoplasm;Nucleoplasm;Nucleus membrane;Cytoskeleton	NA	May be involved in the regulation of cell migration.	NA	NA	NA	PE1	5
+NX_Q86Z23	Complement C1q-like protein 4	238	24909	8.41	0	Secreted	NA	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).	NA	NA	NA	PE1	12
+NX_Q8HWS3	DNA-binding protein RFX6	928	102461	6.11	0	Nucleus	Mitchell-Riley syndrome	Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).	NA	Belongs to the RFX family.	Regulation of gene expression in beta cells	PE1	6
+NX_Q8IU53	Protein CASC2, isoforms 1/2	76	8607	10.35	0	NA	NA	NA	NA	NA	NA	PE4	10
+NX_Q8IU54	Interferon lambda-1	200	21898	9.08	0	Secreted	NA	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.	NA	Belongs to the lambda interferon family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling;Other interleukin signaling	PE1	19
+NX_Q8IU57	Interferon lambda receptor 1	520	57653	4.89	1	Membrane;Cytosol	NA	The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.	NA	Belongs to the type II cytokine receptor family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling;Other interleukin signaling	PE1	1
+NX_Q8IU60	m7GpppN-mRNA hydrolase	420	48423	8.21	0	Cell junction;Nucleoplasm;P-body;Cytosol;Nucleus	NA	Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968, PubMed:28002401). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).	Phosphorylated at ser-249 in a MTOR-dependent manner (PubMed:26098573).	Belongs to the Nudix hydrolase family. DCP2 subfamily.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;mRNA decay by 5' to 3' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA	PE1	5
+NX_Q8IU68	Transmembrane channel-like protein 8	726	81641	9.49	8	Golgi apparatus;Endoplasmic reticulum membrane	Epidermodysplasia verruciformis 2	Probable ion channel.	NA	Belongs to the TMC family.	NA	PE1	17
+NX_Q8IU80	Transmembrane protease serine 6	811	90000	6.25	1	Cell membrane	Iron-refractory iron deficiency anemia	Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.	The single-chain zymogen undergoes autoproteolytic processing. This results in TMPRSS6 shedding from the cell surface and conversion into an activated two-chains form which is released extracellularly. The process involves a trans-activation mechanism that requires TMPRSS6 oligomerization.	Belongs to the peptidase S1 family.	Degradation of the extracellular matrix;Collagen degradation	PE1	22
+NX_Q8IU81	Interferon regulatory factor 2-binding protein 1	584	61688	8.52	0	Nucleoplasm;Nucleus	NA	Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.	NA	Belongs to the IRF2BP family.	NA	PE1	19
+NX_Q8IU85	Calcium/calmodulin-dependent protein kinase type 1D	385	42914	6.77	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	NA	PE1	10
+NX_Q8IU89	Ceramide synthase 3	383	46316	7.63	6	Nucleoplasm;Endoplasmic reticulum membrane	Ichthyosis, congenital, autosomal recessive 9	Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal. Differentiation (PubMed:23754960).	NA	NA	Lipid metabolism; sphingolipid metabolism.;Sphingolipid de novo biosynthesis	PE1	15
+NX_Q8IU99	Calcium homeostasis modulator protein 1	346	38264	8.53	4	Endoplasmic reticulum membrane;Cell membrane	NA	Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.	NA	Belongs to the CALHM family.	NA	PE1	10
+NX_Q8IUA0	WAP four-disulfide core domain protein 8	241	27824	8.43	0	Secreted	NA	NA	NA	NA	NA	PE1	20
+NX_Q8IUA7	ATP-binding cassette sub-family A member 9	1624	184362	6.49	14	Membrane;Endoplasmic reticulum	NA	May play a role in monocyte differentiation and lipid homeostasis.	NA	Belongs to the ABC transporter superfamily. ABCA family.	ABC transporters;ABC transporters in lipid homeostasis	PE1	17
+NX_Q8IUB2	WAP four-disulfide core domain protein 3	231	24687	7.58	0	Secreted	NA	NA	NA	NA	NA	PE2	20
+NX_Q8IUB3	Protein WFDC10B	73	8325	8.82	0	Secreted	NA	NA	NA	NA	NA	PE2	20
+NX_Q8IUB5	WAP four-disulfide core domain protein 13	93	10386	8.41	0	Secreted	NA	Putative acid-stable proteinase inhibitor.	NA	NA	NA	PE2	20
+NX_Q8IUB9	Keratin-associated protein 19-1	90	9008	8.45	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 19 family.	Keratinization	PE2	21
+NX_Q8IUC0	Keratin-associated protein 13-1	172	18320	8.54	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the PMG family.	Keratinization	PE1	21
+NX_Q8IUC1	Keratin-associated protein 11-1	163	17085	8.32	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the PMG family.	Keratinization	PE1	21
+NX_Q8IUC2	Keratin-associated protein 8-1	63	6826	7.6	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 8 family.	Keratinization	PE1	21
+NX_Q8IUC3	Keratin-associated protein 7-1	87	9288	8.57	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 7 family.	NA	PE1	21
+NX_Q8IUC4	Rhophilin-2	686	76993	6.35	0	Perinuclear region	NA	Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.	NA	Belongs to the RHPN family.	RHO GTPases Activate Rhotekin and Rhophilins	PE1	19
+NX_Q8IUC6	TIR domain-containing adapter molecule 1	712	76422	5.24	0	Mitochondrion;Cell membrane;Nucleolus;Nucleoplasm;Autophagosome;Cytosol	Encephalopathy, acute, infection-induced, Herpes-specific, 6	Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity).	(Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to disrupt host TLR3 signaling.;(Microbial infection) Cleaved and degraded by hepatitis A virus (HAV) protein 3CD allowing the virus to disrupt host TLR3 signaling.;Phosphorylated by TBK1 (PubMed:14530355, PubMed:25636800). Following activation, phosphorylated by TBK1 at Ser-210 in the pLxIS motif (PubMed:25636800). The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines (PubMed:25636800, PubMed:27302953).;Polyubiquitinated by TRIM38 with 'Lys-48'-linked chains, leading to proteasomal degradation.	NA	Toll-like receptor signaling pathway;Pertussis;Chagas disease (American trypanosomiasis);Hepatitis C;Influenza A;Herpes simplex infection;RIP-mediated NFkB activation via ZBP1;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;Caspase activation via Death Receptors in the presence of ligand;MyD88-independent TLR4 cascade;TRIF-mediated programmed cell death;TICAM1 deficiency - HSE;TRAF3 deficiency - HSE;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Toll Like Receptor 3 (TLR3) Cascade;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;TICAM1, RIP1-mediated IKK complex recruitment;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;TLR3-mediated TICAM1-dependent programmed cell death	PE1	19
+NX_Q8IUC8	Polypeptide N-acetylgalactosaminyltransferase 13	556	64051	6.41	1	Golgi apparatus membrane	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. May be responsible for the synthesis of Tn antigen in neuronal cells.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	2
+NX_Q8IUD2	ELKS/Rab6-interacting/CAST family member 1	1116	128086	5.72	0	Cytoplasm;Presynaptic cell membrane;Cell membrane;Membrane;Centrosome;Golgi apparatus membrane;Cytoplasmic vesicle;Cytosol	NA	Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.	NA	NA	NA	PE1	12
+NX_Q8IUD6	E3 ubiquitin-protein ligase RNF135	432	47888	6.37	0	Cytoplasm;Cytoplasmic vesicle	NA	Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.	NA	NA	Protein modification; protein ubiquitination.;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;TRAF3-dependent IRF activation pathway;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Ovarian tumor domain proteases	PE1	17
+NX_Q8IUE0	Homeobox protein TGIF2LY	185	20814	9.84	0	Nucleus	NA	May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.	NA	Belongs to the TALE/TGIF homeobox family.	NA	PE1	Y
+NX_Q8IUE1	Homeobox protein TGIF2LX	241	26675	9.13	0	Nucleoplasm;Nucleus	NA	May have a transcription role in testis.	NA	Belongs to the TALE/TGIF homeobox family.	NA	PE1	X
+NX_Q8IUE6	Histone H2A type 2-B	130	13995	10.88	0	Nucleoplasm;Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Deiminated on Arg-4 in granulocytes upon calcium entry.;Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.	Belongs to the histone H2A family.	Systemic lupus erythematosus;RMTs methylate histone arginines;HATs acetylate histones;HDACs deacetylate histones;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs	PE1	1
+NX_Q8IUF1	COBW domain-containing protein 2	395	44034	4.79	0	NA	NA	NA	NA	Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.	NA	PE1	2
+NX_Q8IUF8	Ribosomal oxygenase 2	465	52800	6.23	0	Nucleoplasm;Nucleus;Nucleolus	NA	Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.	NA	Belongs to the ROX family. MINA53 subfamily.	HDMs demethylate histones	PE1	3
+NX_Q8IUG1	Keratin-associated protein 1-3	177	18184	5.53	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 1 family.	Keratinization	PE2	17
+NX_Q8IUG5	Unconventional myosin-XVIIIb	2567	285215	6.45	0	Cytoplasm;Sarcomere;Nucleoplasm;Centrosome;Nucleus	Klippel-Feil syndrome 4, autosomal recessive, with nemaline myopathy and facial dysmorphism	May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	22
+NX_Q8IUH2	Protein CREG2	290	32109	9.18	0	Secreted	NA	NA	It is not sure whether N-glycosylation is on Asn-165 and/or Asn-166.	Belongs to the CREG family.	NA	PE1	2
+NX_Q8IUH3	RNA-binding protein 45	476	53502	6.74	0	Nucleoplasm;Cytoplasm;Nucleus	NA	RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.	NA	NA	NA	PE1	2
+NX_Q8IUH4	Palmitoyltransferase ZDHHC13	622	70861	8.39	6	Cytoplasmic vesicle;Cytoplasmic vesicle membrane;Golgi apparatus membrane	NA	Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport.	NA	Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.	NA	PE1	11
+NX_Q8IUH5	Palmitoyltransferase ZDHHC17	632	72640	7.29	6	Golgi apparatus;Presynaptic cell membrane;Cytoplasmic vesicle membrane;Golgi apparatus membrane;Cytoplasmic vesicle	NA	Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299).	Autopalmitoylated (PubMed:15603740, PubMed:18794299). Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport (PubMed:18794299).	Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.	NA	PE1	12
+NX_Q8IUH8	Signal peptide peptidase-like 2C	684	74503	6.28	9	Membrane;Endoplasmic reticulum membrane	NA	Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.	Glycosylated.	Belongs to the peptidase A22B family.	NA	PE1	17
+NX_Q8IUI4	Putative protein SNX29P2	249	27226	4.8	0	NA	NA	NA	NA	Belongs to the sorting nexin family.	NA	PE5	16
+NX_Q8IUI8	Cytokine receptor-like factor 3	442	49766	5.01	0	Cytoplasm;Cytosol;Cell membrane	NA	May play a role in the negative regulation of cell cycle progression.	NA	Belongs to the cytokine receptor-like factor 3 family.	NA	PE1	17
+NX_Q8IUK5	Plexin domain-containing protein 1	500	55760	5.49	1	Cytoplasm;Tight junction;Secreted;Cell membrane	NA	Plays a critical role in endothelial cell capillary morphogenesis.	N-glycosylated.	Belongs to the plexin family.	NA	PE1	17
+NX_Q8IUK8	Cerebellin-2	224	24084	8.8	0	Secreted	NA	May play role in synaptogenesis induction.	NA	NA	NA	PE1	18
+NX_Q8IUL8	Cartilage intermediate layer protein 2	1156	126291	8.63	0	Extracellular matrix	NA	May play a role in cartilage scaffolding.	May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.	NA	NA	PE1	19
+NX_Q8IUM7	Neuronal PAS domain-containing protein 4	802	87117	4.53	0	Nucleus	NA	Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734).	Ubiquitinated, leading to degradation by the proteosome.	NA	NA	PE1	11
+NX_Q8IUN9	C-type lectin domain family 10 member A	316	35446	5.66	1	Membrane	NA	Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.	NA	NA	Dectin-2 family	PE1	17
+NX_Q8IUQ0	Clavesin-1	354	40788	6.68	0	Early endosome membrane;Clathrin-coated vesicle;trans-Golgi network membrane	NA	Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).	NA	NA	Lysosome Vesicle Biogenesis	PE1	8
+NX_Q8IUQ4	E3 ubiquitin-protein ligase SIAH1	282	31123	6.35	0	Cytoplasm;Nucleoplasm;Mitochondrion;Nucleus	NA	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.	Phosphorylated on Ser-19 by ATM and ATR. This phosphorylation disrupts SIAH1 interaction with HIPK2, and subsequent proteasomal degradation of HIPK2.	Belongs to the SINA (Seven in absentia) family.	Protein modification; protein ubiquitination.;p53 signaling pathway;Ubiquitin mediated proteolysis;Wnt signaling pathway;Antigen processing: Ubiquitination &amp; Proteasome degradation;Amyloid fiber formation;Netrin-1 signaling	PE1	16
+NX_Q8IUR0	Trafficking protein particle complex subunit 5	188	20783	9.69	0	cis-Golgi network;Endoplasmic reticulum;Cytoplasmic vesicle	NA	May play a role in vesicular transport from endoplasmic reticulum to Golgi.	NA	Belongs to the TRAPP small subunits family. BET3 subfamily.	COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs	PE1	19
+NX_Q8IUR5	Protein O-mannosyl-transferase TMTC1	882	98847	9.05	9	Membrane;Nucleoplasm;Cytosol;Endoplasmic reticulum	NA	Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.	NA	Belongs to the TMTC family.	Protein modification; protein glycosylation.	PE1	12
+NX_Q8IUR6	CREB3 regulatory factor	639	72149	4.76	0	Nucleoplasm;Nucleus	NA	Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.	Probably degraded by the proteasome.	Belongs to the bZIP family. CREBRF subfamily.	CREB3 factors activate genes	PE1	5
+NX_Q8IUR7	Armadillo repeat-containing protein 8	673	75509	6.28	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.	NA	NA	Neutrophil degranulation	PE1	3
+NX_Q8IUS5	Epoxide hydrolase 4	362	42324	8.64	1	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.	NA	PE1	1
+NX_Q8IUW3	Spermatogenesis-associated protein 2-like protein	424	46179	5.35	0	Nucleoplasm;Cytosol;Mitochondrion	NA	NA	NA	Belongs to the SPATA2 family.	NA	PE1	16
+NX_Q8IUW5	RELT-like protein 1	271	29340	8.57	1	Cytoskeleton;Cell membrane	NA	Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290).	Phosphorylated in vitro by OXSR1.	Belongs to the RELT family.	NA	PE1	4
+NX_Q8IUX1	Complex I assembly factor TMEM126B, mitochondrial	230	25943	8.96	4	Mitochondrion membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 29	Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I.	NA	Belongs to the TMEM126 family.	Complex I biogenesis	PE1	11
+NX_Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	373	45020	6.85	0	Cytoplasm;P-body	NA	DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	NA	PE1	22
+NX_Q8IUX7	Adipocyte enhancer-binding protein 1	1158	130929	5.05	0	Cytoplasm;Secreted;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	Ehlers-Danlos syndrome, classic-like, 2	May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.;As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellualr matrix.	Phosphorylated by MAPK1 in vitro.	Belongs to the peptidase M14 family.	NA	PE1	7
+NX_Q8IUX8	Epidermal growth factor-like protein 6	553	61317	8.45	0	Basement membrane	NA	May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity).	NA	Belongs to the nephronectin family.	NA	PE1	X
+NX_Q8IUY3	GRAM domain-containing protein 2A	354	40249	8.73	1	Endoplasmic reticulum membrane;Nucleus speckle;Cell membrane;Nucleolus;Cytosol	NA	Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE).	NA	NA	NA	PE1	15
+NX_Q8IUZ0	Leucine-rich repeat-containing protein 49	686	78894	7.94	0	Cytoskeleton	NA	NA	NA	NA	Carboxyterminal post-translational modifications of tubulin	PE1	15
+NX_Q8IUZ5	5-phosphohydroxy-L-lysine phospho-lyase	450	49711	6.28	0	Mitochondrion	Phosphohydroxylysinuria	Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde.	NA	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Collagen degradation;Lysine catabolism	PE1	5
+NX_Q8IV01	Synaptotagmin-12	421	46537	5.37	1	Synaptic vesicle membrane	NA	Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (By similarity). Essential for mossy-fiber long-term potentiation in the hippocampus (By similarity).	Phosphorylation of Ser-97 is required for mossy-fiber long-term potentiation.	Belongs to the synaptotagmin family.	Neurexins and neuroligins	PE1	11
+NX_Q8IV03	Leucine rich adaptor protein 1-like	231	24583	4.98	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	9
+NX_Q8IV04	Carabin	446	49712	9.03	0	Nucleus	NA	Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.	NA	NA	Neutrophil degranulation;TBC/RABGAPs	PE1	11
+NX_Q8IV08	Phospholipase D3	490	54705	6.02	1	Endoplasmic reticulum;Cytosol;Endoplasmic reticulum membrane	Spinocerebellar ataxia 46	May be involved in APP processing.	Glycosylated.	Belongs to the phospholipase D family.	Role of phospholipids in phagocytosis;Synthesis of PG	PE1	19
+NX_Q8IV13	Cyclin-J-like protein	435	48406	7.28	0	Nucleus speckle	NA	NA	NA	Belongs to the cyclin family. Cyclin J subfamily.	NA	PE1	5
+NX_Q8IV16	Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1	184	19806	4.71	0	Basolateral cell membrane;Apical cell membrane;Cell membrane	Hyperlipoproteinemia 1D	Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (By similarity). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (By similarity). Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding (PubMed:27929370, PubMed:29899144). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:19304573, PubMed:21314738). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:17997385, PubMed:19304573). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (By similarity).	Sulfation of a Tyr in the N-terminal acidic region increases the affinity for LPL.;Glycosylation of Asn-78 is critical for cell surface localization.	NA	Retinoid metabolism and transport;Post-translational modification: synthesis of GPI-anchored proteins;Assembly of active LPL and LIPC lipase complexes;Chylomicron remodeling	PE1	8
+NX_Q8IV20	Laccase domain-containing protein 1	430	47780	6.64	0	Peroxisome	Rheumatoid arthritis systemic juvenile	Central regulator of the metabolic function and bioenergetic state of macrophages. In macrophages, promotes flux through de novo lipogenesis to concomitantly drive high levels of both fatty-acid oxidation and glycolysis.	NA	Belongs to the LACC1 family.	NA	PE1	13
+NX_Q8IV31	Transmembrane protein 139	216	23729	4.7	1	Membrane;Focal adhesion;Cell membrane	NA	May be involved in cellular trafficking of proteins such as SLC4A1.	NA	NA	NA	PE1	7
+NX_Q8IV32	Coiled-coil domain-containing protein 71	467	49648	11.8	0	Nucleus membrane	NA	NA	NA	NA	NA	PE1	3
+NX_Q8IV33	Uncharacterized protein KIAA0825	1275	147735	6.18	0	NA	NA	NA	NA	NA	NA	PE1	5
+NX_Q8IV35	WD repeat-containing protein 49	697	79295	8.76	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE2	3
+NX_Q8IV36	Protein HID1	788	88745	5.69	0	Golgi apparatus;Cytoplasm;Cytosol;Golgi apparatus membrane	NA	May play an important role in the development of cancers in a broad range of tissues.	NA	Belongs to the hid-1 family.	NA	PE1	17
+NX_Q8IV38	Ankyrin repeat and MYND domain-containing protein 2	441	49299	5.88	0	Cytoplasm;Cilium;Nucleoplasm;Cytosol;Nucleus	NA	May be involved in the trafficking of signaling proteins to the cilia.	NA	NA	NA	PE1	7
+NX_Q8IV42	L-seryl-tRNA(Sec) kinase	348	39527	8.62	0	Nucleolus;Nucleus;Cytoskeleton	NA	Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.	NA	Belongs to the L-seryl-tRNA(Sec) kinase family.	Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2.;Selenocompound metabolism;Aminoacyl-tRNA biosynthesis;Selenocysteine synthesis	PE1	10
+NX_Q8IV45	UNC5C-like protein	518	57818	6.21	1	Membrane;Cytoplasm;Centrosome	NA	Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.	NA	Belongs to the unc-5 family.	NA	PE1	6
+NX_Q8IV48	3'-5' exoribonuclease 1	349	40064	6.29	0	Cytoplasm;Nucleolus;Cytoplasmic vesicle;Nucleus;Cytoskeleton	NA	RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.	NA	NA	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	8
+NX_Q8IV50	LysM and putative peptidoglycan-binding domain-containing protein 2	215	23463	5.27	0	Mitochondrion;Nucleus	NA	NA	NA	NA	NA	PE1	15
+NX_Q8IV53	DENN domain-containing protein 1C	801	87065	5.46	0	Nucleoplasm;Clathrin-coated vesicle;Cytosol;Centrosome	NA	Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	19
+NX_Q8IV56	Proline-rich protein 15	129	13715	9.64	0	Cytoplasmic vesicle;Cell junction	NA	May have a role in proliferation and/or differentiation.	NA	Belongs to the PRR15 family.	NA	PE1	7
+NX_Q8IV61	Ras guanyl-releasing protein 3	690	78332	6.33	0	Golgi apparatus;Nucleoplasm	NA	Guanine nucleotide exchange factor (GEF) for Ras and Rap1.	NA	Belongs to the RASGRP family.	MAPK signaling pathway;B cell receptor signaling pathway;RAF/MAP kinase cascade;Activation of RAS in B cells	PE1	2
+NX_Q8IV63	Inactive serine/threonine-protein kinase VRK3	474	52881	9.21	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.	VRK3 is phosphorylated by PLK3	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.	ERKs are inactivated	PE1	19
+NX_Q8IV76	Circadian clock protein PASD1	773	87428	4.96	0	Nucleus speckle;Nucleus	NA	Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).	NA	NA	NA	PE1	X
+NX_Q8IV77	Cyclic nucleotide-gated cation channel alpha-4	575	65999	5.4	6	Membrane	NA	Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).	NA	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily.	Olfactory transduction;VxPx cargo-targeting to cilium	PE1	11
+NX_Q8IVA1	Purkinje cell protein 2 homolog	136	14547	4.67	0	Cytoplasmic vesicle;Nucleus speckle	NA	May function as a cell-type specific modulator for G protein-mediated cell signaling.	NA	NA	G alpha (i) signalling events	PE1	19
+NX_Q8IVB4	Sodium/hydrogen exchanger 9	645	72565	5.8	13	Late endosome membrane	Autism 16	May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.	NA	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Sodium/Proton exchangers;Defective SLC9A9 causes autism 16 (AUTS16)	PE1	3
+NX_Q8IVB5	LIX1-like protein	337	36563	8.8	0	Cytosol	NA	NA	NA	Belongs to the LIX1 family.	NA	PE1	1
+NX_Q8IVC4	Zinc finger protein 584	421	48272	9.05	0	Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8IVD9	NudC domain-containing protein 3	361	40822	5.16	0	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	7
+NX_Q8IVE0	Putative ciliary rootlet coiled-coil protein-like 2 protein	287	33334	10.84	0	NA	NA	NA	NA	Belongs to the rootletin family.	NA	PE5	1
+NX_Q8IVE3	Pleckstrin homology domain-containing family H member 2	1493	168229	7.5	0	Cytoplasm;Cell membrane;Nucleoplasm;Lamellipodium;Cytosol;Nucleus;Cytoskeleton	NA	In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.	NA	NA	NA	PE1	2
+NX_Q8IVF1	NUT family member 2A	878	93890	8.6	0	NA	NA	NA	NA	Belongs to the NUT family.	NA	PE2	10
+NX_Q8IVF2	Protein AHNAK2	5795	616629	5.2	0	Cytosol;Nucleus;Cell membrane	NA	NA	NA	NA	NA	PE1	14
+NX_Q8IVF4	Dynein heavy chain 10, axonemal	4471	514841	5.64	0	Cilium axoneme	NA	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.	NA	Belongs to the dynein heavy chain family.	NA	PE1	12
+NX_Q8IVF5	T-lymphoma invasion and metastasis-inducing protein 2	1701	190103	6.8	0	Cytoplasm;Perikaryon;Growth cone;Nucleolus;Nucleoplasm;Lamellipodium;Filopodium;Cytosol;Neuron projection	NA	Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.	Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth (By similarity).	Belongs to the TIAM family.	Chemokine signaling pathway;Regulation of actin cytoskeleton;PPARA activates gene expression;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	6
+NX_Q8IVF6	Ankyrin repeat domain-containing protein 18A	992	115597	7.92	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q8IVF7	Formin-like protein 3	1028	117213	6.23	0	Golgi apparatus;Cytoplasm;Cell membrane;Cytoplasmic vesicle;Cytosol	NA	Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.	NA	Belongs to the formin homology family.	RHO GTPases Activate Formins	PE1	12
+NX_Q8IVG5	Sterile alpha motif domain-containing protein 9-like	1584	184533	8.25	0	Early endosome;Cytosol	Ataxia-pancytopenia syndrome	May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors.	NA	NA	NA	PE1	7
+NX_Q8IVG9	Humanin	24	2687	9.49	0	Cytoplasm;Secreted	NA	Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.	NA	Belongs to the humanin family.	G alpha (i) signalling events;G alpha (q) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands	PE1	MT
+NX_Q8IVH2	Forkhead box protein P4	680	73488	5.97	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional repressor that represses lung-specific expression.	NA	NA	NA	PE1	6
+NX_Q8IVH4	Methylmalonic aciduria type A protein, mitochondrial	418	46538	9.37	0	Cytosol;Mitochondrion	Methylmalonic aciduria type cblA	GTPase, binds and hydrolyzes GTP (PubMed:28497574, PubMed:20876572). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) and reactivation of the enzyme during catalysis (PubMed:28497574, PubMed:20876572).	NA	Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.	Cofactor biosynthesis; adenosylcobalamin biosynthesis.;Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective MMAA causes methylmalonic aciduria type cblA;Defective MUT causes methylmalonic aciduria mut type;Propionyl-CoA catabolism	PE1	4
+NX_Q8IVH8	Mitogen-activated protein kinase kinase kinase kinase 3	894	101316	7.38	0	Nucleoplasm;Centriolar satellite	NA	May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	MAPK signaling pathway	PE1	2
+NX_Q8IVI9	Nostrin	506	57660	9.08	0	Cell membrane;Cytoplasmic vesicle;Cytosol;Nucleus;Cytoskeleton	NA	Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.	NA	NA	NOSTRIN mediated eNOS trafficking	PE1	2
+NX_Q8IVJ1	Solute carrier family 41 member 1	513	54901	5.12	10	Mitochondrion;Cell membrane	NA	Acts as a magnesium transporter that is responsive to magnesium balance.	NA	Belongs to the SLC41A transporter family.	Metal ion SLC transporters	PE1	1
+NX_Q8IVJ8	AP20 region protein 1	170	18525	10.7	1	Membrane	NA	NA	NA	NA	NA	PE2	3
+NX_Q8IVK1	Putative glycosylation-dependent cell adhesion molecule 1	47	5018	9.3	0	NA	NA	NA	NA	Belongs to the PP3/GlyCAM-1 family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE5	12
+NX_Q8IVL0	Neuron navigator 3	2385	255648	8.92	0	Nucleus outer membrane;Cytosol;Nucleus membrane	NA	May regulate IL2 production by T-cells. May be involved in neuron regeneration.	NA	Belongs to the Nav/unc-53 family.	NA	PE1	12
+NX_Q8IVL1	Neuron navigator 2	2488	268167	9.13	0	Nucleoplasm;Nucleus	NA	Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.	NA	Belongs to the Nav/unc-53 family.	NA	PE1	11
+NX_Q8IVL5	Prolyl 3-hydroxylase 2	708	80984	5.48	0	Sarcoplasmic reticulum;Golgi apparatus;Nucleoplasm;Endoplasmic reticulum	Myopia, high, with cataract and vitreoretinal degeneration	Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:18487197). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1 (PubMed:18487197). Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline (PubMed:18487197). Has no activity on substrates that lack 4-hydroxyproline in the third position (PubMed:18487197).	NA	Belongs to the leprecan family.	Collagen biosynthesis and modifying enzymes	PE1	3
+NX_Q8IVL6	Prolyl 3-hydroxylase 3	736	81837	5.93	0	Endoplasmic reticulum;Cytosol;Nucleolus;Cell membrane	NA	Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases.	NA	Belongs to the leprecan family.	Collagen biosynthesis and modifying enzymes	PE1	12
+NX_Q8IVL8	Carboxypeptidase O	374	42529	6.6	0	Apical cell membrane	NA	Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.	N-glycosylated.	Belongs to the peptidase M14 family.	NA	PE1	2
+NX_Q8IVM0	Coiled-coil domain-containing protein 50	306	35822	6.2	0	Cytoplasm;Cytosol	Deafness, autosomal dominant, 44	Involved in EGFR signaling.	Phosphorylated on tyrosine residues.	NA	NA	PE1	3
+NX_Q8IVM7	Putative uncharacterized protein encoded by LINC00346	164	18094	9.29	0	NA	NA	NA	NA	NA	NA	PE5	13
+NX_Q8IVM8	Solute carrier family 22 member 9	553	62169	8.4	12	Basolateral cell membrane	NA	Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	NA	PE1	11
+NX_Q8IVN3	Musculoskeletal embryonic nuclear protein 1	82	8911	9.87	0	Nucleus	NA	May be involved in the development and regeneration of the musculoskeletal system.	NA	Belongs to the MUSTANG family.	NA	PE1	3
+NX_Q8IVN8	Somatomedin-B and thrombospondin type-1 domain-containing protein	264	29610	7.71	0	Cytoplasmic vesicle;Extracellular matrix	NA	NA	NA	Belongs to the thrombospondin family.	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	8
+NX_Q8IVP5	FUN14 domain-containing protein 1	155	17178	8.67	3	Mitochondrion outer membrane	NA	Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.	Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy.	Belongs to the FUN14 family.	Receptor Mediated Mitophagy	PE1	X
+NX_Q8IVP9	Zinc finger protein 547	402	45956	8.71	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8IVQ6	Palmitoyltransferase ZDHHC21	265	31385	8.81	4	Membrane;Golgi apparatus;Cytosol	NA	Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).	NA	Belongs to the DHHC palmitoyltransferase family.	eNOS activation;Extra-nuclear estrogen signaling	PE1	9
+NX_Q8IVS2	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial	390	42962	8.97	0	Mitochondrion	NA	Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria.	NA	Belongs to the type II malonyltransferase family.	Lipid metabolism; fatty acid biosynthesis.;Fatty acid biosynthesis;Metabolic pathways;Mitochondrial Fatty Acid Beta-Oxidation	PE1	22
+NX_Q8IVS8	Glycerate kinase	523	55253	6.25	0	Golgi apparatus;Cytosol;Cytoplasm;Mitochondrion	D-glyceric aciduria	NA	NA	Belongs to the glycerate kinase type-2 family.	Glycine, serine and threonine metabolism;Glycerolipid metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Fructose catabolism	PE1	3
+NX_Q8IVT2	Mitotic interactor and substrate of PLK1	679	75357	6.36	0	Cell cortex;Focal adhesion;Cell membrane;Cytoskeleton	NA	Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.	Phosphorylated by CDK1 and PLK1. CDK1 is the priming kinase for PLK1 phosphorylation. Phosphorylation by PLK1 is required for proper spindle orientation at metaphase.	Belongs to the MISP family.	NA	PE1	19
+NX_Q8IVT5	Kinase suppressor of Ras 1	923	102160	8.94	0	Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Membrane;Ruffle membrane	NA	Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity).	Phosphorylated on Ser-311 and, to a higher extent, on Ser-406 by MARK3. Dephosphorylated on Ser-406 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated. Phosphorylated by PKA at Ser-888. Phosphorylation at Ser-888 is required for cAMP-dependent activation of MAPK1 and/or MAPK3 (By similarity).	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	Tuberculosis;Negative regulation of MAPK pathway;RAF activation;MAP2K and MAPK activation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	17
+NX_Q8IVU1	Immunoglobulin superfamily DCC subclass member 3	814	86724	7.58	1	Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the immunoglobulin superfamily. DCC family.	NA	PE1	15
+NX_Q8IVU3	Probable E3 ubiquitin-protein ligase HERC6	1022	115126	8.22	0	Nucleoplasm;Cytosol	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	4
+NX_Q8IVU9	Ciliary-associated calcium-binding coiled-coil protein 1	208	23883	4.36	0	Cytoplasm;Nucleoplasm;Centrosome;Flagellum;Cytosol	NA	Calcium-binding protein. May be involved in the control of sperm flagellar movement.	NA	NA	NA	PE1	10
+NX_Q8IVV2	Lipoxygenase homology domain-containing protein 1	2067	235677	5.38	0	Stereocilium	Deafness, autosomal recessive, 77	Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity).	NA	NA	NA	PE1	18
+NX_Q8IVV7	Glucose-induced degradation protein 4 homolog	300	33514	9.26	0	Cytosol	NA	Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (Probable) (PubMed:29911972). Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp (PubMed:29632410). Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue (PubMed:29632410).	NA	Belongs to the GID4/VID24 family.	NA	PE1	17
+NX_Q8IVV8	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4	208	23240	5.43	3	Cell membrane	NA	NA	NA	Belongs to the NKAIN family.	NA	PE2	20
+NX_Q8IVW1	ADP-ribosylation factor-like protein 17	177	19388	9.85	0	Golgi apparatus	NA	GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	17
+NX_Q8IVW4	Cyclin-dependent kinase-like 3	592	67514	9.35	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	5
+NX_Q8IVW6	AT-rich interactive domain-containing protein 3B	561	60637	7.05	0	Nucleoplasm;Nucleus	NA	Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.	NA	NA	NA	PE1	15
+NX_Q8IVW8	Protein spinster homolog 2	549	58044	9.43	11	Endosome membrane;Cell membrane	Deafness, autosomal recessive, 115	Acts a a crucial lysosphingolipid sphingosine 1-phosphate (S1P) transporter involved in S1P secretion and function (PubMed:19074308, PubMed:23180825). S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system. Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:19074308, PubMed:23180825).	NA	Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.	NA	PE1	17
+NX_Q8IVY1	Type III endosome membrane protein TEMP	113	12024	5.46	1	Cell membrane;Recycling endosome;Early endosome;Nucleolus;Membrane	NA	May be involved in membrane trafficking between endosomes and plasma membrane.	NA	NA	NA	PE1	1
+NX_Q8IW00	V-set and transmembrane domain-containing protein 4	320	36146	9.88	1	Cytoplasmic vesicle;Nucleoplasm;Secreted;Cell membrane	NA	Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors.	Proteolytically cleaved to generate a bioactive peptide.	NA	NA	PE1	10
+NX_Q8IW03	Seven in absentia homolog 3	269	30660	7.21	0	Mitochondrion	NA	Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria.	NA	Belongs to the SINA (Seven in absentia) family.	NA	PE2	13
+NX_Q8IW19	Aprataxin and PNK-like factor	511	56956	4.98	0	Nucleoplasm;Cytosol;Nucleus;Chromosome	NA	Nuclease involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150). Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721). Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17353262, PubMed:17396150). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721).	Poly-ADP-ribosylated. In addition to binding non covalently poly(ADP-ribose) via its PBZ-type zinc fingers, the protein is also covalently poly-ADP-ribosylated by PARP1.;Phosphorylated in an ATM-dependent manner upon double-strand DNA break.	Belongs to the APLF family.	NA	PE1	2
+NX_Q8IW35	Centrosomal protein of 97 kDa	865	96981	4.92	0	Cytosol;Centriolar satellite;Centrosome	NA	Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.	NA	NA	Anchoring of the basal body to the plasma membrane	PE1	3
+NX_Q8IW36	Zinc finger protein 695	515	60149	8.98	0	Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	1
+NX_Q8IW40	Coiled-coil domain-containing protein 103	242	27163	5.74	0	Cytoplasm;Cytosol;Flagellum	Ciliary dyskinesia, primary, 17	Dynein-attachment factor required for cilia motility.	NA	Belongs to the CCDC103/PR46b family.	NA	PE1	17
+NX_Q8IW41	MAP kinase-activated protein kinase 5	473	54220	7.66	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.	Phosphorylated on Thr-182 ERK3/MAPK6 or ERK4/MAPK4; which is the regulatory phosphorylation site and is located on the T-loop/loop 12, leading to activation. Phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11 is subject to debate. Phosphorylated at Ser-115 by PKA/PRKACA, leading to localization to the cytoplasm. Autophosphorylated (By similarity).	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	MAPK signaling pathway;MAPK6/MAPK4 signaling;Oxidative Stress Induced Senescence;Regulation of TP53 Activity through Phosphorylation	PE1	12
+NX_Q8IW45	ATP-dependent (S)-NAD(P)H-hydrate dehydratase	347	36576	8.21	0	Mitochondrion	Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 2	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.	NA	Belongs to the NnrD/CARKD family.	Nicotinamide salvaging	PE1	13
+NX_Q8IW50	Protein FAM219A	185	20400	4.53	0	Golgi apparatus;Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the FAM219 family.	NA	PE1	9
+NX_Q8IW52	SLIT and NTRK-like protein 4	837	94331	7.95	1	Membrane;Cytoskeleton;Cell membrane	NA	It is involved in synaptogenesis and promotes synapse differentiation (PubMed:27812321). Suppresses neurite outgrowth (By similarity).	NA	Belongs to the SLITRK family.	Receptor-type tyrosine-protein phosphatases	PE1	X
+NX_Q8IW70	Transmembrane protein 151B	566	61506	6.72	2	Membrane	NA	NA	NA	Belongs to the TMEM151 family.	NA	PE1	6
+NX_Q8IW75	Serpin A12	414	47175	9.31	0	Secreted	NA	Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.	Glycosylation slightly decreases affinity for heparin, but otherwise has no significant effect on KLK7 inhibitory activity or thermal stability of the protein.	Belongs to the serpin family.	NA	PE1	14
+NX_Q8IW92	Beta-galactosidase-1-like protein 2	636	72079	7.2	0	Nucleoplasm;Secreted	NA	NA	NA	Belongs to the glycosyl hydrolase 35 family.	NA	PE1	11
+NX_Q8IW93	Rho guanine nucleotide exchange factor 19	802	89197	7.31	0	Nucleus	NA	Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase.	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	1
+NX_Q8IWA0	WD repeat-containing protein 75	830	94499	5.65	0	Nucleoplasm;Nucleolus	NA	Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.	NA	NA	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	2
+NX_Q8IWA4	Mitofusin-1	741	84160	5.93	2	Mitochondrion outer membrane;Cytoplasm;Mitochondrion	NA	Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303).	Ubiquitinated by non-degradative ubiquitin by PRKN (PubMed:23933751). Deubiquitination by USP30 inhibits mitochondrial fusion (By similarity). Ubiquitinated by MARCH5 (PubMed:20103533). When mitochondria are depolarized and dysfunctional, it is ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that contains FBXO7 and PRKN (PubMed:23933751).	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.	Factors involved in megakaryocyte development and platelet production;Pink/Parkin Mediated Mitophagy	PE1	3
+NX_Q8IWA5	Choline transporter-like protein 2	706	80124	8.89	10	Membrane;Cytoplasmic vesicle;Cell junction	NA	But not isoform 3, exhibits some choline transporter activity.	NA	Belongs to the CTL (choline transporter-like) family.	Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Neutrophil degranulation	PE1	19
+NX_Q8IWA6	Coiled-coil domain-containing protein 60	550	63091	9.71	0	NA	NA	NA	NA	NA	NA	PE1	12
+NX_Q8IWB1	Inositol 1,4,5-trisphosphate receptor-interacting protein	547	62060	5.58	1	Cytoplasmic vesicle;Nucleus outer membrane;Cell membrane	NA	Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.	NA	Belongs to the ITPRIP family.	NA	PE1	10
+NX_Q8IWB4	Spermatogenesis-associated protein 31A7	1347	148734	8.96	1	Membrane	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA31 family.	NA	PE2	9
+NX_Q8IWB6	Inactive serine/threonine-protein kinase TEX14	1497	167901	5.04	0	Kinetochore;Cytoplasm;Cell membrane;Cell junction;Cytoplasmic vesicle;Cytosol;Midbody	Spermatogenic failure 23	Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).	Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex.;TEX14 is phosphorylated by CDK1	Belongs to the protein kinase superfamily.	NA	PE1	17
+NX_Q8IWB7	WD repeat and FYVE domain-containing protein 1	410	46324	6.99	0	Early endosome	NA	Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).	NA	NA	NA	PE1	2
+NX_Q8IWB9	Testis-expressed protein 2	1127	125303	5.71	2	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	17
+NX_Q8IWC1	MAP7 domain-containing protein 3	876	98429	9.34	0	Spindle;Centrosome	NA	Promotes the assembly and stability of microtubules.	NA	Belongs to the MAP7 family.	NA	PE1	X
+NX_Q8IWD4	Coiled-coil domain-containing protein 117	279	30541	4.99	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	NA	NA	NA	NA	PE1	22
+NX_Q8IWD5	Major facilitator superfamily domain-containing protein 6-like	586	64005	8.87	11	Membrane;Endoplasmic reticulum	NA	NA	NA	Belongs to the major facilitator superfamily. MFSD6 family.	NA	PE2	17
+NX_Q8IWE2	Protein NOXP20	563	60742	4.61	0	Golgi apparatus;Nucleoplasm;Cytosol;Cytoplasm	NA	May play a role in neuronal cell development.	NA	Belongs to the FAM114 family.	NA	PE1	4
+NX_Q8IWE4	DCN1-like protein 3	304	34291	5.05	0	Nucleoplasm;Cytosol;Cell membrane	NA	Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).	NA	NA	Neddylation	PE1	16
+NX_Q8IWE5	Pleckstrin homology domain-containing family M member 2	1019	112780	4.82	0	Cytoplasm	NA	May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation (PubMed:15905402). May play a role in lysosomes movement and localization at the cell periphery (PubMed:25898167).	NA	NA	Salmonella infection	PE1	1
+NX_Q8IWF2	FAD-dependent oxidoreductase domain-containing protein 2	684	77791	7.39	0	Endoplasmic reticulum lumen	NA	Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.	N-glycosylated.	Belongs to the FOXRED2 family.	NA	PE1	22
+NX_Q8IWF6	Protein DENND6A	608	69575	8.52	0	Cytoplasm;Recycling endosome;Cytoplasmic vesicle	NA	Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.	NA	Belongs to the DENND6 family.	RAB GEFs exchange GTP for GDP on RABs	PE1	3
+NX_Q8IWF7	Putative ubiquitin-conjugating enzyme E2 D2-like protein	75	8761	8.85	0	NA	NA	NA	NA	Belongs to the ubiquitin-conjugating enzyme family.	NA	PE5	X
+NX_Q8IWF9	Coiled-coil domain-containing protein 83	413	48851	5.33	0	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	11
+NX_Q8IWG1	WD repeat-containing protein 63	891	102935	5.52	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q8IWI9	MAX gene-associated protein	3065	336159	6.48	0	Nucleoplasm;Cytosol;Nucleus	NA	Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).	NA	NA	Transcriptional Regulation by E2F6	PE1	15
+NX_Q8IWJ2	GRIP and coiled-coil domain-containing protein 2	1684	195910	5.1	0	Golgi apparatus;Cytoplasm;Nucleoplasm;trans-Golgi network membrane	NA	Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.	NA	NA	Retrograde transport at the Trans-Golgi-Network	PE1	2
+NX_Q8IWK6	Adhesion G protein-coupled receptor A3	1321	146151	8.8	7	Membrane	NA	Orphan receptor that may have a role in planar cell polarity pathway.	NA	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	4
+NX_Q8IWL1	Pulmonary surfactant-associated protein A2	248	26182	5.07	0	Surface film;Extracellular matrix	Pulmonary fibrosis, idiopathic	In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.	N-acetylated.	Belongs to the SFTPA family.	Toll Like Receptor 4 (TLR4) Cascade;Toll Like Receptor TLR1:TLR2 Cascade;Signal regulatory protein family interactions;Surfactant metabolism;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4);Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF);Regulation of TLR by endogenous ligand	PE1	10
+NX_Q8IWL2	Pulmonary surfactant-associated protein A1	248	26242	4.89	0	Surface film;Extracellular matrix	Respiratory distress syndrome in premature infants;Pulmonary fibrosis, idiopathic	In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity).;(Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule (PubMed:17158455, PubMed:21203928). Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages (PubMed:21123169).	N-acetylated.	Belongs to the SFTPA family.	Phagosome;Pertussis;Toll Like Receptor 4 (TLR4) Cascade;Toll Like Receptor TLR1:TLR2 Cascade;Signal regulatory protein family interactions;Surfactant metabolism;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4);Regulation of TLR by endogenous ligand	PE1	10
+NX_Q8IWL3	Iron-sulfur cluster co-chaperone protein HscB	235	27422	7.59	0	Nucleoplasm;Cytosol;Cytoplasm;Mitochondrion	NA	Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm (PubMed:20668094, PubMed:29309586). Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain (PubMed:26749241). Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (PubMed:26749241). Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1 (PubMed:29309586). This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT (PubMed:29309586).	NA	Belongs to the HscB family.	Cofactor biosynthesis; iron-sulfur cluster biosynthesis.;Mitochondrial protein import;Mitochondrial iron-sulfur cluster biogenesis	PE1	22
+NX_Q8IWL8	Saitohin	128	13652	4.72	0	Cytoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	17
+NX_Q8IWN6	Protein FAM223A	122	13808	9.87	0	NA	NA	NA	NA	Belongs to the FAM223 family.	NA	PE2	X
+NX_Q8IWN7	Retinitis pigmentosa 1-like 1 protein	2400	252289	4.41	0	Photoreceptor outer segment;Cilium axoneme	Occult macular dystrophy	Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity).	NA	NA	NA	PE1	8
+NX_Q8IWP9	Coiled-coil domain-containing protein 28A	274	30367	9.32	0	Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	6
+NX_Q8IWQ3	Serine/threonine-protein kinase BRSK2	736	81633	8.97	0	Golgi apparatus;Endoplasmic reticulum;Perinuclear region;Centrosome	NA	Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.	Polyubiquitinated by the APC complex in conjunction with FZR1, leading to its proteasomal degradation. Targeted for proteasomal degradation by interaction with COPS5. BRSK2 levels change during the cell cycle. BRSK2 levels are low at the G1/S boundary and gradually increase as cells progress into G2 phase. BRSK2 levels decrease rapidly at the end of mitosis.;Phosphorylated at Thr-174 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-174 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-174 by PP2C. Phosphorylated at Thr-260 by PKA. Phosphorylation at Thr-260 by PKA was not observed in another study (PubMed:18339622), but this may reflect differences in the experimental approach. Phosphorylation at Thr-260 seems to play a role in the regulation of insulin secretion (PubMed:22669945).;BRSK2 is phosphorylated by CAMKK2	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	NA	PE1	11
+NX_Q8IWR0	Zinc finger CCCH domain-containing protein 7A	971	110538	7	0	Cytosol;Nucleus	NA	May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop.	NA	NA	NA	PE1	16
+NX_Q8IWR1	Tripartite motif-containing protein 59	403	47114	6.36	1	Endoplasmic reticulum membrane	NA	May serve as a multifunctional regulator for innate immune signaling pathways.	NA	Belongs to the TRIM/RBCC family.	NA	PE1	3
+NX_Q8IWS0	PHD finger protein 6	365	41290	8.97	0	Kinetochore;Nucleoplasm;Nucleus;Nucleolus	Boerjeson-Forssman-Lehmann syndrome	Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.	NA	NA	NA	PE1	X
+NX_Q8IWT0	Protein archease	167	19491	4.39	0	Cell membrane	NA	Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.	NA	Belongs to the archease family.	tRNA processing in the nucleus	PE1	1
+NX_Q8IWT1	Sodium channel subunit beta-4	228	24969	6.9	1	Cell membrane	Atrial fibrillation, familial, 17;Long QT syndrome 10	Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.	Contains an interchain disulfide bond with SCN2A.;N-glycosylated.	Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	11
+NX_Q8IWT3	Cullin-9	2517	281229	5.3	0	Cytoplasm;Cytosol	NA	Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).	Neddylated.;In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin.	Belongs to the cullin family.	Neddylation	PE1	6
+NX_Q8IWT6	Volume-regulated anion channel subunit LRRC8A	810	94199	8.15	4	Cell membrane	Agammaglobulinemia 5, autosomal dominant	Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Can form functional channels by itself (in vitro) (PubMed:26824658). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746). Also required for T-cell development (By similarity). May play a role in lysosome homeostasis (PubMed:31270356).	N-glycosylated.	Belongs to the LRRC8 family.	Miscellaneous transport and binding events	PE1	9
+NX_Q8IWU2	Serine/threonine-protein kinase LMTK2	1503	164900	4.35	2	Nucleus speckle;Cell membrane;Centriolar satellite;Membrane;Cytosol	NA	Phosphorylates PPP1C, phosphorylase b and CFTR.	Autophosphorylated. Phosphorylated (By similarity).	Belongs to the protein kinase superfamily. Tyr protein kinase family.	NA	PE1	7
+NX_Q8IWU4	Zinc transporter 8	369	40755	6.11	6	Endoplasmic reticulum;Secretory vesicle membrane;Cell membrane	NA	Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.	NA	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.	Insulin processing;Zinc efflux and compartmentalization by the SLC30 family	PE1	8
+NX_Q8IWU5	Extracellular sulfatase Sulf-2	870	100455	9.3	0	Cell surface;Endoplasmic reticulum;Golgi stack	NA	Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	NA	PE1	20
+NX_Q8IWU6	Extracellular sulfatase Sulf-1	871	101027	9.23	0	Cell surface;Endoplasmic reticulum;Golgi stack	NA	Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	NA	PE1	8
+NX_Q8IWU9	Tryptophan 5-hydroxylase 2	490	56057	6.03	0	NA	Attention deficit-hyperactivity disorder 7;Major depressive disorder	NA	NA	Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.;Tryptophan metabolism;Metabolic pathways;Serotonin and melatonin biosynthesis	PE1	12
+NX_Q8IWV1	Lymphocyte transmembrane adapter 1	398	44085	4.85	1	Golgi apparatus;Cytosol;Cell membrane	NA	Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.	Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2.	NA	NA	PE1	1
+NX_Q8IWV2	Contactin-4	1026	113454	7.24	0	Secreted;Cell membrane	NA	Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.	NA	Belongs to the immunoglobulin superfamily. Contactin family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	3
+NX_Q8IWV7	E3 ubiquitin-protein ligase UBR1	1749	200211	5.67	0	Nucleoplasm;Cytosol;Cytoplasmic vesicle	Johanson-Blizzard syndrome	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.	NA	Belongs to the UBR1 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	15
+NX_Q8IWV8	E3 ubiquitin-protein ligase UBR2	1755	200538	5.84	0	Nucleoplasm;Nucleus;Cell membrane	NA	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retranstoposon mobilization (By similarity).	NA	Belongs to the UBR1 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	6
+NX_Q8IWW6	Rho GTPase-activating protein 12	846	96254	7.29	0	NA	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	NA	NA	Rho GTPase cycle	PE1	10
+NX_Q8IWW8	Hydroxyacid-oxoacid transhydrogenase, mitochondrial	467	50308	7.65	0	Cytoplasmic vesicle;Mitochondrion	NA	Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.	NA	Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	PE1	8
+NX_Q8IWX5	Sphingosine-1-phosphate phosphatase 2	399	44741	9.17	9	Endoplasmic reticulum membrane	NA	Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (PubMed:17113265). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity).	NA	Belongs to the type 2 lipid phosphate phosphatase family.	Sphingolipid metabolism;Sphingolipid de novo biosynthesis	PE1	2
+NX_Q8IWX7	Protein unc-45 homolog B	931	103733	8.03	0	Cytosol	Cataract 43	Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development.	NA	NA	NA	PE1	17
+NX_Q8IWX8	Calcium homeostasis endoplasmic reticulum protein	916	103702	9.15	0	Endoplasmic reticulum;Cytoplasm;Perinuclear region	NA	Involved in calcium homeostasis, growth and proliferation.	NA	NA	Spliceosome;mRNA Splicing - Major Pathway	PE1	19
+NX_Q8IWY4	Signal peptide, CUB and EGF-like domain-containing protein 1	988	107910	6.42	0	Secreted;Cell membrane	NA	Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.	N-glycosylated.;Could be proteolytically cleaved to release a smaller active fragment.	NA	Degradation of the extracellular matrix	PE1	22
+NX_Q8IWY8	Zinc finger and SCAN domain-containing protein 29	852	96719	6.55	0	Nucleoplasm;Cytoskeleton;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	15
+NX_Q8IWY9	Codanin-1	1227	134120	6.35	2	Cytoplasm;Cell membrane;Membrane;Cytosol;Nucleus	Anemia, congenital dyserythropoietic, 1A	May act as a negative regulator of ASF1 in chromatin assembly.	NA	NA	NA	PE1	15
+NX_Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	2542	269458	5.46	0	Cytoplasm	NA	May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells.;May possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.	NA	Belongs to the mask family.	NA	PE1	5
+NX_Q8IWZ4	Tripartite motif-containing protein 48	208	24498	8.69	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	Interferon gamma signaling	PE2	11
+NX_Q8IWZ5	Tripartite motif-containing protein 42	723	82745	8.3	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE1	3
+NX_Q8IWZ6	Bardet-Biedl syndrome 7 protein	715	80353	5.7	0	Cilium membrane;Cytoplasm;Centriolar satellite;Cilium basal body	Bardet-Biedl syndrome 7	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.	NA	NA	BBSome-mediated cargo-targeting to cilium	PE1	4
+NX_Q8IWZ8	SURP and G-patch domain-containing protein 1	645	72471	7.2	0	Nucleoplasm;Nucleus	NA	Plays a role in pre-mRNA splicing.	NA	NA	mRNA Splicing - Major Pathway	PE1	19
+NX_Q8IX01	SURP and G-patch domain-containing protein 2	1082	120207	6.92	0	Nucleoplasm;Nucleus	NA	May play a role in mRNA splicing.	NA	NA	NA	PE1	19
+NX_Q8IX03	Protein KIBRA	1113	125301	5.65	0	Golgi apparatus;Cytoplasm;Ruffle membrane;Perinuclear region;Nucleus	NA	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.	Phosphorylation at Ser-542 and Ser-931 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B.	Belongs to the WWC family. KIBRA subfamily.	Signaling by Hippo;NOTCH3 Intracellular Domain Regulates Transcription	PE1	5
+NX_Q8IX04	Ubiquitin-conjugating enzyme E2 variant 3	471	52264	6.61	0	Nucleoplasm;Cytosol	NA	Possible negative regulator of polyubiquitination.	NA	In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.;In the C-terminal section; belongs to the LDH/MDH superfamily.	NA	PE1	11
+NX_Q8IX05	CD302 antigen	232	26183	4.45	1	Membrane;Filopodium;Microvillus;Cell cortex	NA	Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.	May be heterogeneously N-glycosylated in some cell types.	NA	NA	PE1	2
+NX_Q8IX06	Putative exonuclease GOR	675	73855	9.33	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the REXO1/REXO3 family.	Ribosome biogenesis in eukaryotes	PE5	8
+NX_Q8IX07	Zinc finger protein ZFPM1	1006	104888	8.14	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus;Cytosol	NA	Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).	NA	Belongs to the FOG (Friend of GATA) family.	Factors involved in megakaryocyte development and platelet production;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	16
+NX_Q8IX12	Cell division cycle and apoptosis regulator protein 1	1150	132821	5.57	0	Perinuclear region	NA	Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).	NA	NA	mRNA Splicing - Major Pathway	PE1	10
+NX_Q8IX15	Homeobox and leucine zipper protein Homez	550	61240	4.86	0	Nucleoplasm;Nucleus;Nucleolus	NA	May function as a transcriptional regulator.	NA	NA	NA	PE1	14
+NX_Q8IX18	Probable ATP-dependent RNA helicase DHX40	779	88560	8.93	0	Nucleoplasm	NA	Probable ATP-dependent RNA helicase.	NA	Belongs to the DEAD box helicase family. DEAH subfamily.	NA	PE1	17
+NX_Q8IX19	Mast cell-expressed membrane protein 1	187	21229	9.03	1	Membrane	NA	NA	NA	NA	Neutrophil degranulation	PE1	19
+NX_Q8IX21	SMC5-SMC6 complex localization factor protein 2	1173	131873	9.09	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).	NA	Belongs to the FAM178 family.	NA	PE1	10
+NX_Q8IX29	F-box only protein 16	292	34588	10.05	0	Nucleoplasm;Cytoplasmic vesicle;Cytosol;Cell membrane	NA	Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.	NA	NA	NA	PE1	8
+NX_Q8IX30	Signal peptide, CUB and EGF-like domain-containing protein 3	993	109282	7.85	0	Cell surface;Secreted;Cell membrane	NA	Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.	Proteolytic cleavage produces a CUB-containing C-terminal fragment that retains the ability to bind to TGFBR2. This reaction is catalyzed in vitro by MMP2 and, to a lesser extent, by MMP9.;N-glycosylated.	NA	Degradation of the extracellular matrix	PE1	6
+NX_Q8IX90	Spindle and kinetochore-associated protein 3	412	46359	4.99	0	Centrosome;Cytosol;Spindle;Kinetochore;Cytoskeleton	NA	Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).	NA	Belongs to the SKA3 family.	NA	PE1	13
+NX_Q8IX94	cTAGE family member 4	777	87989	5.18	1	Membrane	NA	Tumor-associated antigen.	NA	Belongs to the cTAGE family.	NA	PE2	7
+NX_Q8IX95	Putative cTAGE family member 3	158	18015	4.85	0	NA	NA	Tumor-associated antigen.	NA	Belongs to the cTAGE family.	NA	PE5	13
+NX_Q8IXA5	Sperm acrosome membrane-associated protein 3	215	23431	8.27	1	Acrosome membrane;Secreted	NA	Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.	The processed form derives from the membrane form by proteolytic processing.	Belongs to the glycosyl hydrolase 22 family.	NA	PE1	17
+NX_Q8IXB1	DnaJ homolog subfamily C member 10	793	91080	6.78	0	Endoplasmic reticulum lumen	NA	Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.	NA	NA	Protein processing in endoplasmic reticulum	PE1	2
+NX_Q8IXB3	Trafficking regulator of GLUT4 1	177	19254	7.79	2	Endomembrane system;Perinuclear region;Cell membrane	NA	Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation.	NA	Belongs to the CD225/Dispanin family.	NA	PE1	17
+NX_Q8IXE1	Olfactory receptor 4N5	308	34696	7.99	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	14
+NX_Q8IXF0	Neuronal PAS domain-containing protein 3	933	100805	6.16	0	Nucleoplasm;Nucleus	NA	May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity).	NA	NA	NA	PE1	14
+NX_Q8IXF9	Aquaporin-12A	295	31475	8.49	6	Membrane	NA	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.	Passive transport by Aquaporins	PE2	2
+NX_Q8IXH6	Tumor protein p53-inducible nuclear protein 2	220	23980	6.33	0	Cytosol;Autophagosome;PML body;Nucleus	NA	Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.	NA	NA	NA	PE1	20
+NX_Q8IXH7	Negative elongation factor C/D	590	66247	4.98	0	Nucleoplasm;Cytosol;Nucleus;Cytoplasmic vesicle	NA	Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401).;(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.	NA	Belongs to the NELF-D family.	Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes	PE1	20
+NX_Q8IXH8	Cadherin-like protein 26	832	92416	4.8	1	Cytoskeleton;Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation (PubMed:28051089).	N-glycosylated.	NA	NA	PE1	20
+NX_Q8IXI1	Mitochondrial Rho GTPase 2	618	68118	5.55	1	Mitochondrion outer membrane;Nucleoplasm;Mitochondrion	NA	Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).	NA	Belongs to the mitochondrial Rho GTPase family.	Rho GTPase cycle	PE1	16
+NX_Q8IXI2	Mitochondrial Rho GTPase 1	618	70784	5.87	1	Mitochondrion outer membrane	NA	Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	Belongs to the mitochondrial Rho GTPase family.	Rho GTPase cycle;Ub-specific processing proteases	PE1	17
+NX_Q8IXJ6	NAD-dependent protein deacetylase sirtuin-2	389	43182	5.22	0	Cytoplasm;Nucleus;Centriole;Perikaryon;Growth cone;Cell projection;Nucleolus;Chromosome;Nucleoplasm;Centrosome;Myelin membrane;Cytosol;Spindle;Perinuclear region;Midbody;Cytoskeleton	NA	Lacks deacetylation activity.;Deacetylates EP300, alpha-tubulin and histone H3 and H4.;NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:24177535, PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20587414, PubMed:21081649, PubMed:20543840, PubMed:22014574, PubMed:21726808, PubMed:21949390, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24940000, PubMed:24769394, PubMed:24681946). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression (PubMed:23468428). Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response (PubMed:23468428). Deacetylates also histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition. Upon bacterium Listeria monocytogenes infection, deacetylates 'Lys-18' of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection (PubMed:23908241). During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis (PubMed:24940000). Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells. Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity. Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells. Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy (PubMed:20543840). Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation (By similarity). Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia (PubMed:24681946). Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300 (PubMed:18249187). Deacetylates also EIF5A (PubMed:22771473). Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor (PubMed:22014574).;Deacetylates EP300, alpha-tubulin and histone H3 and H4.	Ubiquitinated.;Phosphorylated at phosphoserine and phosphothreonine. Phosphorylated at Ser-368 by a mitotic kinase CDK1/cyclin B at the G2/M transition; phosphorylation regulates the delay in cell-cycle progression. Phosphorylated at Ser-368 by a mitotic kinase G1/S-specific cyclin E/Cdk2 complex; phosphorylation inactivates SIRT2-mediated alpha-tubulin deacetylation and thereby negatively regulates cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Phosphorylated by cyclin A/Cdk2 and p35-Cdk5 complexes and to a lesser extent by the cyclin D3/Cdk4 and cyclin B/Cdk1, in vitro. Dephosphorylated at Ser-368 by CDC14A and CDC14B around early anaphase.;Acetylated by EP300; acetylation leads both to the decreased of SIRT2-mediated alpha-tubulin deacetylase activity and SIRT2-mediated down-regulation of TP53 transcriptional activity.	Belongs to the sirtuin family. Class I subfamily.	NA	PE1	19
+NX_Q8IXJ9	Polycomb group protein ASXL1	1541	165432	5.85	0	Nucleoplasm;Nucleolus;Nucleus	Bohring-Opitz syndrome;Myelodysplastic syndrome	Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744).	Ubiquitinated by TRIP12, leading to its subsequent degradation following binding N(6)-methyladenosine methylated DNA (m6A).	Belongs to the Asx family.	UCH proteinases	PE1	20
+NX_Q8IXK0	Polyhomeotic-like protein 2	858	90713	8.93	0	Nucleoplasm;Nucleus	NA	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.	NA	NA	SUMOylation of DNA damage response and repair proteins;Oxidative Stress Induced Senescence;SUMOylation of RNA binding proteins;SUMOylation of chromatin organization proteins;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins	PE1	1
+NX_Q8IXK2	Polypeptide N-acetylgalactosaminyltransferase 12	581	66938	6.35	1	Golgi apparatus membrane	Colorectal cancer 1	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins;Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	9
+NX_Q8IXL6	Extracellular serine/threonine protein kinase FAM20C	584	66234	7.65	0	Golgi apparatus;Nucleoplasm;Secreted	Raine syndrome	Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039).	Autophosphorylated.;N-glycosylation is required for folding.	Belongs to the FAM20 family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	7
+NX_Q8IXL7	Methionine-R-sulfoxide reductase B3	192	20702	7.01	0	Endoplasmic reticulum;Mitochondrion	Deafness, autosomal recessive, 74	Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine.;Is essential for hearing.	NA	Belongs to the MsrB Met sulfoxide reductase family.	Protein repair	PE1	12
+NX_Q8IXL9	IQ domain-containing protein F2	164	19627	10.57	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_Q8IXM2	Chromatin complexes subunit BAP18	172	17900	6.74	0	Nucleoplasm;Cytosol;Nucleus	NA	Component of chromatin complexes such as the MLL1/MLL and NURF complexes.	NA	NA	NA	PE1	17
+NX_Q8IXM3	39S ribosomal protein L41, mitochondrial	137	15383	9.59	0	Mitochondrion	NA	Component of the mitochondrial ribosome large subunit (PubMed:28892042, PubMed:25838379, PubMed:25278503). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).	NA	Belongs to the mitochondrion-specific ribosomal protein mL41 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	9
+NX_Q8IXM6	Nurim	262	29379	8.82	6	Nucleus inner membrane;Nucleus membrane	NA	NA	NA	Belongs to the nurim family.	NA	PE1	6
+NX_Q8IXM7	Outer dense fiber protein 3-like protein 1	274	31065	9.6	0	NA	NA	NA	NA	Belongs to the ODF3 family.	NA	PE1	15
+NX_Q8IXN7	N-acetylaspartylglutamate synthase A	391	42864	6.22	0	Cytoplasm;Nucleolus	NA	Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate.	NA	Belongs to the RimK family.	Glutamate and glutamine metabolism	PE1	1
+NX_Q8IXP5	Uncharacterized protein C11orf53	236	25393	4.7	0	NA	NA	NA	NA	NA	NA	PE2	11
+NX_Q8IXQ3	Uncharacterized protein C9orf40	194	21063	4.89	0	Cytoplasm;Nucleoplasm;Centrosome;Cytosol	NA	NA	NA	NA	NA	PE1	9
+NX_Q8IXQ4	GPALPP motifs-containing protein 1	340	38142	5.25	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	13
+NX_Q8IXQ5	Kelch-like protein 7	586	65992	6.08	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	Retinitis pigmentosa 42;Crisponi/Cold-induced sweating syndrome 3	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.	NA	NA	Protein modification; protein ubiquitination.	PE1	7
+NX_Q8IXQ6	Protein mono-ADP-ribosyltransferase PARP9	854	96343	8.12	0	Nucleoplasm;Cytosol;Mitochondrion;Nucleus	NA	ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity (PubMed:28525742). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300).	ADP-ribosylated by PARP14.	NA	Nicotinamide salvaging	PE1	3
+NX_Q8IXQ8	PDZ domain-containing protein 9	264	29904	8.99	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_Q8IXQ9	Electron transfer flavoprotein beta subunit lysine methyltransferase	262	29461	6.05	0	Cytoplasm;Mitochondrion matrix	NA	Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781). Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781).	NA	Belongs to the methyltransferase superfamily. ETFBKMT family.	Protein methylation	PE1	12
+NX_Q8IXR5	Protein FAM178B	827	93514	5.98	0	Golgi apparatus;Nucleus speckle	NA	NA	NA	Belongs to the FAM178 family.	NA	PE1	2
+NX_Q8IXR9	Uncharacterized protein C12orf56	622	71046	9.33	0	NA	NA	NA	NA	NA	NA	PE2	12
+NX_Q8IXS0	Protein FAM217A	508	57420	8.72	0	NA	NA	NA	NA	Belongs to the FAM217 family.	NA	PE2	6
+NX_Q8IXS2	Dynein regulatory complex subunit 2	484	57297	6.96	0	Flagellum axoneme;Centriolar satellite;Flagellum;Flagellum basal body;Cytoplasmic vesicle	Ciliary dyskinesia, primary, 27	Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:24094744).	NA	Belongs to the DRC2 family.	NA	PE1	12
+NX_Q8IXS6	Paralemmin-2	379	42185	5.04	0	Cell membrane	NA	NA	NA	Belongs to the paralemmin family.	NA	PE1	9
+NX_Q8IXS8	Protein FAM126B	530	58647	8.01	0	Nucleoplasm;Cytosol;Cell junction;Cell membrane	NA	Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.	NA	Belongs to the FAM126 family.	NA	PE1	2
+NX_Q8IXT1	DNA damage-induced apoptosis suppressor protein	998	111616	6.8	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	May be an anti-apoptotic protein involved in DNA repair or cell survival.	NA	NA	NA	PE1	11
+NX_Q8IXT2	Doublesex- and mab-3-related transcription factor C2	367	39124	9.18	0	Nucleus	NA	May be involved in sexual development.	NA	Belongs to the DMRT family.	NA	PE1	19
+NX_Q8IXT5	RNA-binding protein 12B	1001	118103	6.34	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	8
+NX_Q8IXU6	Solute carrier family 35 member F2	374	41212	5.86	10	Membrane;Mitochondrion	NA	Putative solute transporter.	NA	Belongs to the SLC35F solute transporter family.	NA	PE1	11
+NX_Q8IXV7	Kelch domain-containing protein 8B	354	37676	8.61	0	Cytoplasm;Cytosol;Midbody	Lymphoma, Hodgkin, classic	Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010).	NA	NA	NA	PE1	3
+NX_Q8IXW0	Lamin tail domain-containing protein 2	634	70379	9.12	0	Cytosol	NA	NA	NA	NA	NA	PE1	11
+NX_Q8IXW5	Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2	612	69509	7.86	0	Cytoplasm;Nucleolus;Nucleus;Cytosol	NA	Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.	NA	Belongs to the RPAP2 family.	RNA polymerase II transcribes snRNA genes	PE1	1
+NX_Q8IXX5	Transmembrane protein 183A	376	42826	9.28	1	Membrane	NA	NA	NA	Belongs to the TMEM183 family.	NA	PE1	1
+NX_Q8IXY8	Probable inactive peptidyl-prolyl cis-trans isomerase-like 6	311	35228	6.55	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.	NA	Belongs to the cyclophilin-type PPIase family.	mRNA Splicing - Major Pathway	PE1	6
+NX_Q8IXZ2	Zinc finger CCCH domain-containing protein 3	948	101941	10.95	0	Nucleoplasm;Nucleus	NA	Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity).	NA	NA	NA	PE1	8
+NX_Q8IXZ3	Transcription factor Sp8	490	48674	9.1	0	Nucleoplasm;Nucleus	NA	Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	7
+NX_Q8IY17	Neuropathy target esterase	1375	150954	7.89	1	Endoplasmic reticulum membrane	Spastic paraplegia 39, autosomal recessive;Boucher-Neuhauser syndrome;Laurence-Moon syndrome;Oliver-McFarlane syndrome	Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.	Glycosylated.	Belongs to the NTE family.	Glycerophospholipid metabolism;Glycerophospholipid catabolism	PE1	19
+NX_Q8IY18	Structural maintenance of chromosomes protein 5	1101	128806	8.63	0	Nucleus speckle;Chromosome;Telomere;PML body;Nucleus	NA	Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).	Ubiquitinated.;Sumoylated.;(Microbial infection) SMC5-SMC6 complex is degraded by the activity of Hepatitis B X protein.	Belongs to the SMC family. SMC5 subfamily.	SUMOylation of DNA damage response and repair proteins	PE1	9
+NX_Q8IY21	Probable ATP-dependent RNA helicase DDX60	1712	197853	7.53	0	Cytoplasm;Cytosol;Cytoskeleton	NA	Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).	NA	Belongs to the helicase family.	NA	PE1	4
+NX_Q8IY22	C-Maf-inducing protein	773	86331	6.26	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Plays a role in T-cell signaling pathway.;May play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.	NA	NA	NA	PE1	16
+NX_Q8IY26	Phospholipid phosphatase 6	295	32194	10.03	4	Membrane;Cytoplasmic vesicle;Cytosol;Nucleoplasm	NA	Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.	PLPP6 is phosphorylated by PRKCB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the PA-phosphatase related phosphoesterase family.	Cholesterol biosynthesis	PE1	9
+NX_Q8IY31	Intraflagellar transport protein 20 homolog	132	15281	5.07	0	Golgi apparatus;Centriole;Cilium;Cilium basal body;cis-Golgi network;Cytoskeleton	NA	Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (By similarity). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity).	NA	NA	Intraflagellar transport	PE1	17
+NX_Q8IY33	MICAL-like protein 2	904	97502	9.63	0	Cell membrane;Recycling endosome;Cell projection;Tight junction;Cytosol;Cytoskeleton	NA	Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity).	NA	NA	NA	PE1	7
+NX_Q8IY34	Solute carrier family 15 member 3	581	63560	9.27	12	Cytoplasmic vesicle;Lysosome membrane	NA	Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).	NA	Belongs to the PTR2/POT transporter (TC 2.A.17) family.	Proton/oligopeptide cotransporters	PE1	11
+NX_Q8IY37	Probable ATP-dependent RNA helicase DHX37	1157	129545	8.36	0	Nucleus membrane	NA	NA	NA	Belongs to the DEAD box helicase family. DEAH subfamily.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	12
+NX_Q8IY42	Uncharacterized protein C4orf19	314	33742	4.36	0	Cell junction	NA	NA	NA	NA	NA	PE1	4
+NX_Q8IY45	Protein AMN1 homolog	258	28408	8.15	0	Centrosome	NA	NA	NA	Belongs to the AMN1 family.	NA	PE1	12
+NX_Q8IY47	Kelch repeat and BTB domain-containing protein 2	623	71331	5.42	0	Cytoplasm;Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	7
+NX_Q8IY49	Monocyte to macrophage differentiation factor 2	270	31264	8.97	7	Golgi apparatus membrane	NA	NA	NA	Belongs to the ADIPOR family.	NA	PE1	7
+NX_Q8IY50	Putative thiamine transporter SLC35F3	421	46817	9.57	10	Membrane;Golgi apparatus;Nucleolus;Cell membrane	NA	May be a thiamine transporter.	NA	Belongs to the SLC35F solute transporter family.	NA	PE1	1
+NX_Q8IY51	Tigger transposable element-derived protein 4	512	57468	6.05	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	Belongs to the tigger transposable element derived protein family.	NA	PE1	4
+NX_Q8IY57	YY1-associated factor 2	180	19901	9.74	0	Nucleoplasm;Nucleus	NA	Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.	NA	NA	Transcriptional Regulation by E2F6;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	12
+NX_Q8IY63	Angiomotin-like protein 1	956	106574	6.62	0	Cytosol;Tight junction;Cell junction;Cytoskeleton	NA	Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.	Polyubiquitinated by NEDD4, leading to proteasomal degradation.	Belongs to the angiomotin family.	Tight junction;Signaling by Hippo	PE1	11
+NX_Q8IY67	Ribonucleoprotein PTB-binding 1	606	63877	8.79	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).	NA	NA	NA	PE1	19
+NX_Q8IY81	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3	847	96558	8.53	0	Nucleolus	NA	(Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973).;RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.	Citrullinated by PADI4.	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	17
+NX_Q8IY82	Dynein regulatory complex subunit 7	874	103497	5.49	0	Flagellum axoneme;Cilium axoneme;Flagellum	NA	Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility.	NA	Belongs to the DRC7 family.	NA	PE1	16
+NX_Q8IY84	Serine/threonine-protein kinase NIM1	436	49606	8.53	0	Cytosol	NA	NA	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	5
+NX_Q8IY85	EF-hand calcium-binding domain-containing protein 13	973	110129	6.15	0	Nucleoplasm;Cytosol;Nucleus speckle	NA	NA	NA	NA	NA	PE2	17
+NX_Q8IY92	Structure-specific endonuclease subunit SLX4	1834	200012	5.74	0	Nucleoplasm;Cytosol;Cell junction;Nucleus	Fanconi anemia complementation group P	Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.	NA	Belongs to the SLX4 family.	Fanconi anemia pathway;Resolution of D-loop Structures through Holliday Junction Intermediates;Fanconi Anemia Pathway	PE1	16
+NX_Q8IY95	Transmembrane protein 192	271	30922	8.13	4	Lysosome membrane;Nucleoplasm;Endosome;Late endosome;Lysosome	NA	NA	Not N-glycosylated.	Belongs to the TMEM192 family.	NA	PE1	4
+NX_Q8IYA2	Putative coiled-coil domain-containing protein 144C	1237	143112	5.51	0	NA	NA	NA	NA	Belongs to the CCDC144 family.	NA	PE5	17
+NX_Q8IYA6	Cytoskeleton-associated protein 2-like	745	83587	9.84	0	Spindle pole;Spindle;Cytosol	Filippi syndrome	Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells.	Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C).	Belongs to the CKAP2 family.	NA	PE1	2
+NX_Q8IYA7	Homeobox protein Mohawk	352	39331	9.66	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	May act as a morphogenetic regulator of cell adhesion.	NA	Belongs to the TALE/IRO homeobox family.	NA	PE1	10
+NX_Q8IYA8	Interactor of HORMAD1 protein 1	594	66343	8.55	0	Nucleoplasm;Chromosome	NA	Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.	NA	NA	NA	PE1	3
+NX_Q8IYB0	Putative uncharacterized protein MGC39545	196	21182	9.8	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q8IYB1	Protein MB21D2	491	55800	6.58	0	Cytosol	NA	NA	NA	Belongs to the mab-21 family.	NA	PE1	3
+NX_Q8IYB3	Serine/arginine repetitive matrix protein 1	904	102335	11.84	0	Nucleus matrix;Nucleus speckle;Nucleus	NA	Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.	Citrullinated by PADI4.;Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown (PubMed:29973724). Phosphorylation by DYRK3 promotes disassembly of nuclear speckles (PubMed:29973724).	Belongs to the splicing factor SR family.	RNA transport;mRNA surveillance pathway;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	1
+NX_Q8IYB4	PEX5-related protein	626	69697	5.18	0	Membrane;Cytoplasm	NA	Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.	NA	Belongs to the peroxisomal targeting signal receptor family.	NA	PE1	3
+NX_Q8IYB5	Stromal membrane-associated protein 1	467	50386	8.92	0	Golgi apparatus;Cytosol;Cell membrane	NA	GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity).	NA	NA	Endocytosis	PE1	6
+NX_Q8IYB7	DIS3-like exonuclease 2	885	99279	5.74	0	Cytoplasm;P-body	Perlman syndrome	3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.	NA	Belongs to the RNR ribonuclease family. DIS3L2 subfamily.	NA	PE1	2
+NX_Q8IYB8	ATP-dependent RNA helicase SUPV3L1, mitochondrial	786	87991	8.21	0	Mitochondrion matrix;Mitochondrion;Nucleus;Mitochondrion nucleoid	NA	Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.	NA	Belongs to the helicase family.	NA	PE1	10
+NX_Q8IYB9	Zinc finger protein 595	648	74302	9.3	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	4
+NX_Q8IYD1	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	628	68883	5.31	0	Cytoplasm	NA	Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.	mRNA surveillance pathway;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs	PE1	X
+NX_Q8IYD2	Kelch domain-containing protein 8A	350	38859	9.36	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q8IYD8	Fanconi anemia group M protein	2048	232191	5.76	0	Nucleoplasm;Nucleus	Premature ovarian failure 15;Spermatogenic failure 28	DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434).	Phosphorylated; hyperphosphorylated in response to genotoxic stress.	Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.	Fanconi anemia pathway;Fanconi Anemia Pathway	PE1	14
+NX_Q8IYD9	Lung adenoma susceptibility protein 2	372	41811	8.43	0	Nucleoplasm;Secreted	NA	Might play a role in cell proliferation.	NA	NA	NA	PE1	18
+NX_Q8IYE0	Coiled-coil domain-containing protein 146	955	112806	8.59	0	Cytoplasmic vesicle;Golgi apparatus;Centriole	NA	NA	NA	NA	NA	PE1	7
+NX_Q8IYE1	Coiled-coil domain-containing protein 13	715	80884	8.82	0	Centriolar satellite;Centrosome;Cilium basal body	NA	Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.	NA	NA	NA	PE1	3
+NX_Q8IYF1	Elongin-A2	753	83921	9.76	0	Nucleus	NA	SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).	NA	NA	Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes	PE1	18
+NX_Q8IYF3	Testis-expressed protein 11	940	107889	5.07	0	Chromosome	Spermatogenic failure, X-linked, 2	Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.	NA	Belongs to the SPO22 family.	NA	PE1	X
+NX_Q8IYG6	Leucine-rich repeat-containing protein 56	542	58733	8.05	0	Cilium	Ciliary dyskinesia, primary, 39	Required for the assembly of dynein arms.	NA	Belongs to the LRRC56 family.	NA	PE1	11
+NX_Q8IYH5	ZZ-type zinc finger-containing protein 3	903	102023	5.48	0	Nucleoplasm;Nucleus;Nucleolus	NA	Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.	NA	NA	HATs acetylate histones	PE1	1
+NX_Q8IYI0	Shieldin complex subunit 1	205	22938	4.72	0	Endoplasmic reticulum;Cytoplasmic vesicle;Golgi apparatus;Chromosome	NA	Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.	NA	NA	NA	PE1	20
+NX_Q8IYI6	Exocyst complex component 8	725	81799	5.35	0	Cytoplasm;Growth cone;Cell projection;Cytosol;Perinuclear region	NA	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	NA	Belongs to the EXO84 family.	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium	PE1	1
+NX_Q8IYI8	Zinc finger protein 440	595	69106	9.33	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8IYJ0	PILR alpha-associated neural protein	282	30076	9.29	1	Membrane;Nucleoplasm	NA	Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation.	O-glycosylation at Thr-140 is essential for recognition by PILRA.	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	12
+NX_Q8IYJ1	Copine-9	553	61864	5.18	0	NA	NA	Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).	NA	Belongs to the copine family.	NA	PE1	3
+NX_Q8IYJ2	Uncharacterized protein C10orf67, mitochondrial	551	63656	8.91	0	Nucleoplasm;Nucleus speckle;Nucleolus;Mitochondrion	NA	NA	NA	NA	NA	PE1	10
+NX_Q8IYJ3	Synaptotagmin-like protein 1	562	61857	5.32	0	Cell membrane	NA	May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).	NA	NA	TBC/RABGAPs	PE1	1
+NX_Q8IYK2	Coiled-coil domain-containing protein 105	499	56909	9.89	0	NA	NA	NA	NA	NA	NA	PE1	19
+NX_Q8IYK4	Procollagen galactosyltransferase 2	626	72924	5.82	0	Nucleoplasm;Endoplasmic reticulum lumen;Cytoplasmic vesicle	NA	Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen.	NA	Belongs to the glycosyltransferase 25 family.	Lysine degradation;Other types of O-glycan biosynthesis;Collagen biosynthesis and modifying enzymes	PE1	1
+NX_Q8IYK8	GTP-binding protein REM 2	340	37139	8.33	0	Cell membrane	NA	Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.	NA	Belongs to the small GTPase superfamily. RGK family.	NA	PE1	14
+NX_Q8IYL2	Probable tRNA (uracil-O(2)-)-methyltransferase	757	84629	6.98	0	Cytoplasm;Nucleoplasm	NA	Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.	NA	Belongs to the TRM44 family.	tRNA modification in the nucleus and cytosol	PE1	4
+NX_Q8IYL3	UPF0688 protein C1orf174	243	25977	6.45	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the UPF0688 family.	NA	PE1	1
+NX_Q8IYL9	Psychosine receptor	337	39333	8.12	7	Cytoplasmic vesicle;Cytosol;Nucleolus;Cell membrane	NA	Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (q) signalling events;Class A/1 (Rhodopsin-like receptors)	PE1	14
+NX_Q8IYM0	Protein FAM186B	893	103722	9.08	0	NA	NA	NA	NA	Belongs to the FAM186 family.	NA	PE1	12
+NX_Q8IYM1	Septin-12	358	40748	6.67	0	Cytoplasm;Flagellum;Spindle;Nucleus;Cytoskeleton	Spermatogenic failure 10	Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	NA	PE1	16
+NX_Q8IYM2	Schlafen family member 12	578	66972	8.84	0	NA	NA	NA	NA	Belongs to the Schlafen family. Subgroup II subfamily.	NA	PE1	17
+NX_Q8IYM9	E3 ubiquitin-protein ligase TRIM22	498	56947	7.97	0	Cajal body;Cytoplasm;Nucleus speckle;Nucleoplasm;Nucleus	NA	Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.	Auto-ubiquitinated.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Interferon gamma signaling	PE1	11
+NX_Q8IYN0	Zinc finger protein 100	542	62745	9.17	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8IYN2	Transcription elongation factor A protein-like 8	117	13616	5.32	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the TFS-II family. TFA subfamily.	NA	PE1	X
+NX_Q8IYN6	UBA-like domain-containing protein 2	164	17877	6.78	0	NA	NA	NA	NA	Belongs to the UBALD family.	NA	PE1	17
+NX_Q8IYP2	Serine protease 58	241	27085	6.36	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE1	7
+NX_Q8IYP9	Palmitoyltransferase ZDHHC23	409	45983	8.97	6	Membrane;Nucleoplasm	NA	Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.	NA	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	3
+NX_Q8IYQ7	Threonine synthase-like 1	743	83070	6.69	0	Cytosol;Mitochondrion;Nucleus	NA	NA	NA	Belongs to the threonine synthase family.	NA	PE1	10
+NX_Q8IYR0	Cilia- and flagella-associated protein 206	622	71193	6.38	0	Nucleoplasm;Cell junction;Cilium axoneme	NA	May regulate cilium motility through its role in the assembly of the axonemal radial spokes.	NA	Belongs to the CFAP206 family.	NA	PE1	6
+NX_Q8IYR2	SET and MYND domain-containing protein 4	804	89225	6.39	0	Golgi apparatus;Nucleoplasm;Cytosol;Cytoplasmic vesicle	NA	NA	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE1	17
+NX_Q8IYR6	Tomoregulin-1	380	40934	6.27	1	Cell membrane	NA	May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers.	NA	Belongs to the tomoregulin family.	NA	PE1	9
+NX_Q8IYS0	Protein Aster-C	662	76035	6.81	1	Cytosol;Endoplasmic reticulum membrane;Cell membrane	NA	Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity).	NA	NA	NA	PE1	3
+NX_Q8IYS1	Peptidase M20 domain-containing protein 2	436	47776	5.56	0	Nucleoplasm	NA	NA	NA	Belongs to the peptidase M20A family.	NA	PE1	6
+NX_Q8IYS2	Uncharacterized protein KIAA2013	634	69157	8.44	1	Membrane;Golgi apparatus;Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q8IYS4	Uncharacterized protein C16orf71	520	55682	4.83	0	Nucleus speckle	NA	NA	NA	NA	NA	PE1	16
+NX_Q8IYS5	Osteoclast-associated immunoglobulin-like receptor	282	30481	6.09	0	Nucleoplasm;Cytosol;Secreted;Cell membrane	NA	Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.	NA	Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.	Osteoclast differentiation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Neutrophil degranulation	PE1	19
+NX_Q8IYS8	Biorientation of chromosomes in cell division protein 1-like 2	172	18075	5.1	0	Centrosome;Kinetochore	NA	May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.	NA	Belongs to the BOD1 family.	NA	PE1	18
+NX_Q8IYT1	Protein FAM71A	594	63177	9.67	0	NA	NA	NA	NA	Belongs to the FAM71 family.	NA	PE1	1
+NX_Q8IYT2	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2	770	88120	6.57	0	Cytoplasm;Cell junction;Nucleus speckle;Nucleus	NA	S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.	NA	NA	NA	PE1	16
+NX_Q8IYT3	Coiled-coil domain-containing protein 170	715	82277	6.22	0	Golgi apparatus;Cell junction	NA	NA	NA	NA	NA	PE1	6
+NX_Q8IYT4	Katanin p60 ATPase-containing subunit A-like 2	538	61253	7.22	0	Cytoplasm;Nucleoplasm;Spindle pole;Spindle;Cytoskeleton	NA	Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	NA	Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.	NA	PE1	18
+NX_Q8IYT8	Serine/threonine-protein kinase ULK2	1036	112694	8.84	0	Cytoplasmic vesicle membrane	NA	Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.	Autophosphorylated. In response to nutrient limitation, probably phosphorylated and activated by AMPK, leading to activate autophagy.;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	Regulation of autophagy;mTOR signaling pathway	PE1	17
+NX_Q8IYU2	E3 ubiquitin-protein ligase HACE1	909	102342	5.58	0	Golgi stack membrane;Cytoplasm;Endoplasmic reticulum;Nucleus	Spastic paraplegia and psychomotor retardation with or without seizures	E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	6
+NX_Q8IYU4	Ubiquilin-like protein	475	52897	5.67	0	NA	NA	NA	NA	NA	Protein processing in endoplasmic reticulum	PE1	11
+NX_Q8IYU8	Calcium uptake protein 2, mitochondrial	434	49666	9.17	0	Nucleoplasm;Mitochondrion intermembrane space;Mitochondrion	NA	Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).	NA	Belongs to the MICU1 family. MICU2 subfamily.	Processing of SMDT1;Mitochondrial calcium ion transport	PE1	13
+NX_Q8IYV9	Izumo sperm-egg fusion protein 1	350	38930	6.11	1	Acrosome membrane;Cell membrane	NA	Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg (PubMed:15759005). The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:15759005). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:15759005).	Phosphorylated. The cytoplasmic C-terminus is phosphorylated and undergoes phosphorylation changes during epididymal transit.;N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm.	Belongs to the Izumo family.	Acrosome Reaction and Sperm:Oocyte Membrane Binding	PE1	19
+NX_Q8IYW2	Cilia- and flagella-associated protein 46	2715	303500	7.07	0	Cilium axoneme	NA	As part of the central apparatus of the cilium axoneme plays a role in cilium movement.	NA	Belongs to the CFAP46 family.	NA	PE1	10
+NX_Q8IYW4	ENTH domain-containing protein 1	607	67538	6.16	0	NA	NA	NA	NA	NA	NA	PE1	22
+NX_Q8IYW5	E3 ubiquitin-protein ligase RNF168	571	65020	8.26	0	Nucleoplasm;Nucleus	Riddle syndrome	E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).	Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).;Ubiquitinated.	Belongs to the RNF168 family.	Protein modification; protein ubiquitination.;SUMOylation of DNA damage response and repair proteins;G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ)	PE1	3
+NX_Q8IYX0	Zinc finger protein 679	411	47179	9.17	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q8IYX1	TBC1 domain family member 21	336	39221	5.81	0	Acrosome;Cytoskeleton	NA	May act as a GTPase-activating protein for Rab family protein(s) (PubMed:19077034). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978).	NA	NA	NA	PE1	15
+NX_Q8IYX3	Coiled-coil domain-containing protein 116	613	67946	8.83	0	Centrosome	NA	NA	NA	NA	NA	PE1	22
+NX_Q8IYX4	Dead end protein homolog 1	353	38687	9.74	0	Cytoplasm;Nucleus	NA	RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).	NA	NA	NA	PE1	5
+NX_Q8IYX7	Stabilizer of axonemal microtubules 1	474	54621	8.68	0	Flagellum axoneme;Centriole;Cilium basal body;Centrosome;Cilium axoneme	NA	May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature.	NA	Belongs to the FAM154 family.	NA	PE1	9
+NX_Q8IYX8	Centrosomal protein CEP57L1	460	53649	8.82	0	Cytosol;Centrosome;Cell membrane	NA	Centrosomal protein which may be required for microtubule attachment to centrosomes.	NA	Belongs to the translokin family.	NA	PE1	6
+NX_Q8IYY4	Zinc finger protein DZIP1L	767	86848	6.85	0	Nucleoplasm;Cytoskeleton;Cilium basal body;Centriole	Polycystic kidney disease 5	Involved in primary cilium formation (PubMed:19852954, PubMed:28530676). Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (PubMed:28530676).	NA	Belongs to the DZIP C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q8IZ02	Leucine-rich repeat-containing protein 34	464	51277	6.32	0	Cytoplasm;Cell junction;Nucleolus;Nucleus;Cytoskeleton	NA	Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro.	NA	NA	NA	PE1	3
+NX_Q8IZ07	Ankyrin repeat domain-containing protein 13A	590	67619	4.93	0	Late endosome;Cell membrane	NA	Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	Monoubiquitinated, inhibits interaction with ubiquitinated EGFR.	NA	NA	PE1	12
+NX_Q8IZ08	G-protein coupled receptor 135	494	51736	9.88	7	Cell membrane;Endosome membrane	NA	Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	14
+NX_Q8IZ13	Protein ZBED8	594	68327	5.98	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	5
+NX_Q8IZ16	Uncharacterized protein C7orf61	206	23862	10.41	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	7
+NX_Q8IZ20	Tissue-resident T-cell transcription regulator protein ZNF683	524	56905	9.01	0	Nucleus	NA	Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells.;Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T-cells.;Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Plays also a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_Q8IZ21	Phosphatase and actin regulator 4	702	78211	6.2	0	Cytoplasm;Cell membrane;Lamellipodium;Cytosol;Cytoskeleton	NA	Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).	NA	Belongs to the phosphatase and actin regulator family.	NA	PE1	1
+NX_Q8IZ26	Zinc finger protein 34	560	64038	9.05	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	8
+NX_Q8IZ40	REST corepressor 2	523	58012	9.08	0	Midbody;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	May act as a component of a corepressor complex that represses transcription.	NA	Belongs to the CoREST family.	NA	PE1	11
+NX_Q8IZ41	Ras and EF-hand domain-containing protein	740	82879	4.99	0	Perinuclear region;Cytoskeleton	NA	Binds predominantly GDP, and also GTP.	NA	Belongs to the small GTPase superfamily. Rab family.	NA	PE1	9
+NX_Q8IZ52	Chondroitin sulfate synthase 2	775	85467	6.45	1	Mitochondrion;Mitochondrion matrix;Golgi stack membrane;Centrosome;Cytoplasmic vesicle;Cytosol	NA	May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress.;Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer.	NA	Belongs to the chondroitin N-acetylgalactosaminyltransferase family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Metabolic pathways;Chondroitin sulfate biosynthesis	PE1	2
+NX_Q8IZ57	Neurensin-1	195	21475	7.61	2	Membrane;Cytosol;Neuron projection;Cell membrane	NA	May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory consolidation (By similarity).	NA	Belongs to the VMP family.	NA	PE1	6
+NX_Q8IZ63	Proline-rich protein 22	422	43980	4.97	0	Nucleoplasm;Cytosol;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	19
+NX_Q8IZ69	tRNA (uracil-5-)-methyltransferase homolog A	625	68726	8.21	0	Nucleoplasm;Cytosol	NA	May be involved in nucleic acid metabolism and/or modifications.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.	NA	PE1	22
+NX_Q8IZ73	RNA pseudouridylate synthase domain-containing protein 2	545	61311	6.72	0	Nucleoplasm;Cytoskeleton	NA	NA	NA	Belongs to the pseudouridine synthase RluA family.	NA	PE1	15
+NX_Q8IZ81	ELMO domain-containing protein 2	293	34961	8.12	0	Nucleoplasm;Cytosol;Nucleolus	NA	Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.	NA	NA	NA	PE1	4
+NX_Q8IZ83	Aldehyde dehydrogenase family 16 member A1	802	85127	6.35	0	Mitochondrion	NA	NA	NA	Belongs to the aldehyde dehydrogenase family.	NA	PE1	19
+NX_Q8IZ96	CKLF-like MARVEL transmembrane domain-containing protein 1	169	18576	6.5	4	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the chemokine-like factor family.	NA	PE1	16
+NX_Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	1049	115658	5.71	2	Golgi apparatus;Cell membrane;trans-Golgi network membrane;Nucleolus;Cytoplasmic granule membrane;Golgi apparatus membrane	NA	(Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system.;Possible role in axon guidance through interaction with RTN4R.	N-glycosylated.	NA	NA	PE1	1
+NX_Q8IZA3	Histone H1oo	346	35813	11.27	0	Cytoplasm;Nucleus;Chromosome	NA	May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).	NA	Belongs to the histone H1/H5 family.	NA	PE2	3
+NX_Q8IZC4	Rhotekin-2	609	69304	8.03	0	Nucleoplasm;Mitochondrion	NA	May play an important role in lymphopoiesis.	NA	NA	NA	PE1	10
+NX_Q8IZC6	Collagen alpha-1(XXVII) chain	1860	186892	9.83	0	Extracellular matrix	Steel syndrome	Plays a role during the calcification of cartilage and the transition of cartilage to bone.	NA	Belongs to the fibrillar collagen family.	Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;MET activates PTK2 signaling;Collagen chain trimerization	PE1	9
+NX_Q8IZC7	Zinc finger protein 101	436	50339	9.67	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8IZD0	Sterile alpha motif domain-containing protein 14	417	45056	9.41	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	17
+NX_Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	1858	204965	7.41	0	Cytoplasm;Nucleus speckle;Cell membrane;Chromosome;Nucleoplasm;Centrosome;Cytoplasmic vesicle;Nucleus	NA	Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity.;Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity).	Ubiquitinated. Deubiquitinated by USP7.;O-glycosylated at Ser-435 and Thr-440 in the SET domain by OGT which probably prevents KMT2E proteasomal-mediated degradation.	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	Lysine degradation;PKMTs methylate histone lysines;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	7
+NX_Q8IZD4	mRNA-decapping enzyme 1B	617	67723	8.75	0	Cytoplasm;Cytosol;Nucleus;Cytoplasmic vesicle	NA	May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).	NA	Belongs to the DCP1 family.	RNA degradation;mRNA decay by 5' to 3' exoribonuclease	PE1	12
+NX_Q8IZD6	Solute carrier family 22 member 15	547	60540	5.41	12	Membrane	NA	Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Organic cation transport	PE1	1
+NX_Q8IZD9	Dedicator of cytokinesis protein 3	2030	233103	6.52	0	Cytoplasm;Cytosol	Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia	Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity).	NA	Belongs to the DOCK family.	Factors involved in megakaryocyte development and platelet production;NTRK2 activates RAC1	PE1	3
+NX_Q8IZE3	Protein-associating with the carboxyl-terminal domain of ezrin	742	82857	4.96	0	Golgi apparatus;Cytoplasm;Lamellipodium;Nucleus;Cytoskeleton	NA	May play a role in regulating cell adhesion/migration complexes in migrating cells.	Phosphorylated.;May be myristoylated; myristoylation may target it to Golgi compartment.	Belongs to the protein kinase superfamily.	NA	PE1	1
+NX_Q8IZF0	Sodium leak channel non-selective protein	1738	200331	8.93	24	Membrane	Hypotonia, infantile, with psychomotor retardation and characteristic facies 1;Congenital contractures of the limbs and face, hypotonia, and developmental delay	Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (By similarity).	Phosphorylated on tyrosine residues.	Belongs to the cation-nonselective channel family.	Stimuli-sensing channels	PE1	13
+NX_Q8IZF2	Adhesion G protein-coupled receptor F5	1346	149457	6.23	7	Cell membrane	NA	Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function.	Highly glycosylated.;Proteolytically cleaved at multiple sites: one in the GPS domain (S1 site) and the other in the SEA domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. The proteolytic cleavage at S2 site generates a fragment that undergoes proteolytic cleavage by the processing enzyme furin.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	Surfactant metabolism	PE1	6
+NX_Q8IZF3	Adhesion G protein-coupled receptor F4	695	77719	9.23	7	Membrane;Mitochondrion	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	6
+NX_Q8IZF4	Adhesion G-protein coupled receptor G5	528	59000	8.69	7	Cytoplasmic vesicle;Nucleoplasm;Nucleus membrane;Cell membrane	NA	Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway.	Autoproteolysis between residues Leu-226 and Thr-227 occurs in the lumen of the endoplasmic reticulum during receptor biosynthesis. The N-terminal fragment (NTF) subsequently reassociates with the C-terminal fragment (CTF) either in a homogeneric heterodimerization, or with another family member through heterogeneric heterodimerization. Autocatalytic cleavage is thought to be critical for the maturation, stability, trafficking, and function.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	16
+NX_Q8IZF5	Adhesion G-protein coupled receptor F3	1079	116341	7.44	7	Membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE2	2
+NX_Q8IZF6	Adhesion G-protein coupled receptor G4	3080	333368	5.82	7	Membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE2	X
+NX_Q8IZF7	Adhesion G-protein coupled receptor F2	708	78569	8.45	7	Membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE2	6
+NX_Q8IZH2	5'-3' exoribonuclease 1	1706	194107	6.78	0	Cytoplasm;Cytosol;Cell membrane	NA	Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).	NA	Belongs to the 5'-3' exonuclease family.	Ribosome biogenesis in eukaryotes;RNA degradation;mRNA decay by 5' to 3' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	PE1	3
+NX_Q8IZI9	Interferon lambda-3	196	21706	8.69	0	Secreted	NA	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.	NA	Belongs to the lambda interferon family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling	PE1	19
+NX_Q8IZJ0	Interferon lambda-2	200	22288	8.15	0	Secreted	NA	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.	NA	Belongs to the lambda interferon family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling	PE2	19
+NX_Q8IZJ1	Netrin receptor UNC5B	945	103638	5.68	1	Membrane raft;Cell membrane	NA	Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).	Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.;Phosphorylated on cytoplasmic tyrosine residues.;Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.	Belongs to the unc-5 family.	Axon guidance;Netrin-1 signaling;Caspase activation via Dependence Receptors in the absence of ligand;Netrin mediated repulsion signals	PE1	10
+NX_Q8IZJ3	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8	1885	206702	6	0	Focal adhesion;Secreted;Cell membrane	Anterior segment dysgenesis 8	NA	Proteolytically cleaved into 2 chains of about 70 and 130 kDa. The fragments are not connected by disulfide bonds.	Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.	NA	PE1	19
+NX_Q8IZJ4	Ral-GDS-related protein	473	52346	8.17	0	Cytoplasmic vesicle;Centrosome	NA	NA	NA	NA	NA	PE2	22
+NX_Q8IZJ6	Inactive L-threonine 3-dehydrogenase, mitochondrial	230	25407	9.58	0	Mitochondrion	NA	NA	NA	Belongs to the NAD(P)-dependent epimerase/dehydratase family.	Threonine catabolism	PE2	8
+NX_Q8IZK6	Mucolipin-2	566	65942	7.73	6	Cell membrane;Lysosome membrane;Recycling endosome membrane;Late endosome membrane;Cytoskeleton	NA	Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840).	NA	Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN2 sub-subfamily.	TRP channels	PE1	1
+NX_Q8IZL2	Mastermind-like protein 2	1156	125197	9.45	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.	NA	Belongs to the mastermind family.	Notch signaling pathway;Pre-NOTCH Transcription and Translation;Notch-HLH transcription pathway;NOTCH2 intracellular domain regulates transcription;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE1	11
+NX_Q8IZL8	Proline-, glutamic acid- and leucine-rich protein 1	1130	119700	4.29	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211).	Transiently sumoylated, preferentially conjugated to SUMO2 or SUMO3. Sumoylation causes nucleolar exclusion of PELP1 and promotes the recruitment of MDN1 to pre-60S particles. Desumoylation by SUMO isopeptidase SENP3 is needed to release both PELP1 and MDN1 from pre-ribosomes.	Belongs to the RIX1/PELP1 family.	Major pathway of rRNA processing in the nucleolus and cytosol;PTK6 Expression	PE1	17
+NX_Q8IZL9	Cyclin-dependent kinase 20	346	38695	6.27	0	Nucleoplasm;Cytoplasm;Cilium;Nucleus	NA	Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	9
+NX_Q8IZM0	Putative CNGA1-overlapping antisense gene protein	81	9081	11.39	0	NA	NA	NA	NA	NA	NA	PE5	4
+NX_Q8IZM8	Zinc finger protein 654	581	65854	5.36	0	Nucleoplasm;Spindle;Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q8IZM9	Probable sodium-coupled neutral amino acid transporter 6	456	50929	8.02	11	Cell junction;Cell membrane;Cytoskeleton	NA	Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.	NA	Belongs to the amino acid/polyamine transporter 2 family.	NA	PE1	14
+NX_Q8IZN3	Probable palmitoyltransferase ZDHHC14	488	53388	8.59	4	Membrane;Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.	NA	PE1	6
+NX_Q8IZN7	Beta-defensin 107	70	7846	9.45	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	8
+NX_Q8IZP0	Abl interactor 1	508	55081	6.57	0	Cytoplasm;Cell membrane;Cell junction;Growth cone;Lamellipodium;Filopodium;Postsynaptic density;Cytosol;Nucleus;Cytoskeleton	NA	May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.	Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization.	Belongs to the ABI family.	Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;VEGFA-VEGFR2 Pathway	PE1	10
+NX_Q8IZP1	TBC1 domain family member 3	549	62187	9.24	0	Cell membrane	NA	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11.	Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.;Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.	NA	TBC/RABGAPs	PE1	17
+NX_Q8IZP2	Putative protein FAM10A4	240	27407	5.01	0	Cytoplasm	NA	NA	NA	Belongs to the FAM10 family.	NA	PE5	13
+NX_Q8IZP6	RING finger protein 113B	322	36259	7.54	0	NA	NA	NA	NA	NA	NA	PE1	13
+NX_Q8IZP7	Heparan-sulfate 6-O-sulfotransferase 3	471	54844	6.39	1	Cell membrane;Nucleus membrane;Membrane;Nucleoplasm;Cytoskeleton	NA	6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.	NA	Belongs to the sulfotransferase 6 family.	Glycosaminoglycan biosynthesis - heparan sulfate;HS-GAG biosynthesis	PE1	13
+NX_Q8IZP9	Adhesion G-protein coupled receptor G2	1017	111593	7.66	7	Apical cell membrane;Cytosol;Cell membrane	Congenital bilateral aplasia of the vas deferens, X-linked	Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.	Highly glycosylated.;Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	X
+NX_Q8IZQ1	WD repeat and FYVE domain-containing protein 3	3526	395258	6.3	0	Cell membrane;Perikaryon;Nucleolus;Nucleus membrane;Membrane;PML body;Cytosol;Axon	Microcephaly 18, primary, autosomal dominant	Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400).	NA	NA	NA	PE1	4
+NX_Q8IZQ5	Selenoprotein H	122	13453	9.76	0	Nucleoplasm;Nucleolus	NA	May be involved in a redox-related process.	NA	Belongs to the SelWTH family.	NA	PE1	11
+NX_Q8IZQ8	Myocardin	938	101997	6.17	0	Nucleoplasm;Nucleus	NA	Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).	Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity.	NA	NA	PE1	17
+NX_Q8IZR5	CKLF-like MARVEL transmembrane domain-containing protein 4	234	25828	7.65	4	Membrane;Golgi apparatus;Cell membrane;Cytoplasmic vesicle	NA	Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.	NA	Belongs to the chemokine-like factor family.	NA	PE1	16
+NX_Q8IZS5	Orofacial cleft 1 candidate gene 1 protein	231	26754	5.89	0	NA	NA	NA	NA	NA	NA	PE1	6
+NX_Q8IZS6	Tctex1 domain-containing protein 3	198	23176	9.34	0	Membrane;Cytoplasmic granule;Cytoskeleton	NA	May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity).	NA	Belongs to the dynein light chain Tctex-type family.	Intraflagellar transport	PE1	6
+NX_Q8IZS7	C-type lectin-like domain family 1	167	19115	9.44	1	Centriolar satellite;Cell membrane	NA	May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.	NA	NA	NA	PE2	12
+NX_Q8IZS8	Voltage-dependent calcium channel subunit alpha-2/delta-3	1091	123011	5.53	1	Membrane;Nucleoplasm	NA	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).	N-glycosylated.;May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).	Belongs to the calcium channel subunit alpha-2/delta family.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Presynaptic depolarization and calcium channel opening;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	3
+NX_Q8IZT6	Abnormal spindle-like microcephaly-associated protein	3477	409800	10.45	0	Cytoplasm;Cell membrane;Cytosol;Spindle;Nucleus	Microcephaly 5, primary, autosomal recessive	Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.	NA	NA	NA	PE1	1
+NX_Q8IZT8	Heparan sulfate glucosamine 3-O-sulfotransferase 5	346	40408	9.8	1	Golgi apparatus membrane	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.	NA	Belongs to the sulfotransferase 1 family.	Glycosaminoglycan biosynthesis - heparan sulfate;HS-GAG biosynthesis	PE1	6
+NX_Q8IZT9	Protein FAM9C	166	19210	5.16	0	Nucleus	NA	NA	NA	Belongs to the FAM9 family.	NA	PE1	X
+NX_Q8IZU0	Protein FAM9B	186	22438	5.31	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the FAM9 family.	NA	PE1	X
+NX_Q8IZU1	Protein FAM9A	332	37339	4.82	0	Nucleolus	NA	NA	NA	Belongs to the FAM9 family.	NA	PE1	X
+NX_Q8IZU2	WD repeat-containing protein 17	1322	147703	6.01	0	Nucleus speckle	NA	NA	NA	NA	NA	PE1	4
+NX_Q8IZU3	Synaptonemal complex protein 3	236	27729	9.22	0	Centromere;Nucleus;Chromosome	Spermatogenic failure 4;Pregnancy loss, recurrent, 4	Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).	Phosphorylated.	Belongs to the XLR/SYCP3 family.	Meiotic synapsis	PE1	12
+NX_Q8IZU8	Dermatan-sulfate epimerase-like protein	1212	139238	8.48	2	Membrane;Nucleoplasm;Cell membrane	NA	NA	NA	Belongs to the dermatan-sulfate isomerase family.	Dermatan sulfate biosynthesis	PE1	18
+NX_Q8IZU9	Kin of IRRE-like protein 3	778	85255	6.46	1	Secreted;Cell membrane	NA	Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.	Undergoes proteolysis by a metalloprotease and gives rise to a soluble form.	Belongs to the immunoglobulin superfamily.	Nephrin family interactions	PE1	11
+NX_Q8IZV2	CKLF-like MARVEL transmembrane domain-containing protein 8	173	19572	6.06	4	Membrane;Cytoplasm;Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the chemokine-like factor family.	NA	PE1	3
+NX_Q8IZV5	Retinol dehydrogenase 10	341	38087	7.11	1	Microsome membrane;Endoplasmic reticulum membrane;Lipid droplet	NA	Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Cofactor metabolism; retinol metabolism.;Retinol metabolism;Metabolic pathways;The canonical retinoid cycle in rods (twilight vision);RA biosynthesis pathway	PE1	8
+NX_Q8IZW8	Tensin-4	715	76764	7.01	0	Focal adhesion;Cytoskeleton	NA	May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.	Proteolytically cleaved by caspase-3 during apoptosis.	NA	MET interacts with TNS proteins	PE1	17
+NX_Q8IZX4	Transcription initiation factor TFIID subunit 1-like	1826	207302	5.26	0	Nucleus	NA	May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.	NA	Belongs to the TAF1 family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation	PE1	9
+NX_Q8IZY2	Phospholipid-transporting ATPase ABCA7	2146	234350	6.85	15	Golgi apparatus;Cytoplasm;Cell membrane;Cell junction;Endoplasmic reticulum;Phagocytic cup;Golgi apparatus membrane;Early endosome membrane;Ruffle membrane	Alzheimer disease 9	Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791).	N-glycosylated.	Belongs to the ABC transporter superfamily. ABCA family.	ABC transporters;ABC transporters in lipid homeostasis	PE1	19
+NX_Q8IZY5	BH3-like motif-containing cell death inducer	108	12045	6.73	0	Cytoplasm;Mitochondrion	NA	Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death.	NA	NA	NA	PE1	11
+NX_Q8J025	Protein APCDD1	514	58797	8.43	1	Cell membrane	Hypotrichosis 1	Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.	N-Glycosylated.	Belongs to the APCDD1 family.	NA	PE1	18
+NX_Q8MH63	Putative L-type amino acid transporter 1-like protein MLAS	180	18779	6.72	3	Membrane	NA	NA	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.	NA	PE5	16
+NX_Q8N0S2	Synaptonemal complex central element protein 1	351	39699	5.89	0	Chromosome;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	Spermatogenic failure, 15;Premature ovarian failure 12	Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.	NA	Belongs to the SYCE family.	Meiotic synapsis	PE1	10
+NX_Q8N0S6	Centromere protein L	344	38998	6.08	0	Centromere;Nucleus	NA	Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.	NA	Belongs to the CENP-L/IML3 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	1
+NX_Q8N0T1	Ribosomal biogenesis factor	100	11456	10.46	0	Nucleoplasm;Cytosol;Mitochondrion;Nucleolus	NA	Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production.	NA	NA	NA	PE1	8
+NX_Q8N0U2	Transmembrane protein 61	210	22170	4.54	2	Membrane	NA	NA	NA	NA	NA	PE2	1
+NX_Q8N0U4	Protein FAM185A	392	42301	8.22	0	Cytosol	NA	NA	NA	NA	NA	PE1	7
+NX_Q8N0U6	Putative uncharacterized protein encoded by LINC00518	118	13361	4.89	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_Q8N0U7	Uncharacterized protein C1orf87	546	62035	8.82	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q8N0U8	Vitamin K epoxide reductase complex subunit 1-like protein 1	176	19836	9.28	4	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.	NA	Belongs to the VKOR family.	Metabolism of vitamin K	PE1	7
+NX_Q8N0V1	Putative uncharacterized protein ZNF295-AS1	137	14971	9.08	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_Q8N0V3	Putative ribosome-binding factor A, mitochondrial	343	38359	8.01	0	Mitochondrion	NA	NA	NA	Belongs to the RbfA family.	NA	PE1	18
+NX_Q8N0V4	Leucine-rich repeat LGI family member 2	545	62298	6.47	0	Centrosome;Secreted	NA	NA	NA	NA	LGI-ADAM interactions	PE1	4
+NX_Q8N0V5	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase	402	45873	6.73	1	Golgi apparatus;Golgi apparatus membrane	Cataract 13, with adult i phenotype	Determines the expression of the blood group I antigen in erythrocytes.;Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells.	NA	Belongs to the glycosyltransferase 14 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways	PE1	6
+NX_Q8N0W3	L-fucose kinase	1084	117623	5.84	0	Cytoplasmic vesicle	Congenital disorder of glycosylation with defective fucosylation 2	Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.	NA	Belongs to the GHMP kinase family.	Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;GDP-fucose biosynthesis	PE1	16
+NX_Q8N0W4	Neuroligin-4, X-linked	816	91915	5.78	1	Postsynaptic density;Cell membrane	Autism, X-linked 2;Asperger syndrome, X-linked, 2	Putative neuronal cell surface protein involved in cell-cell-interactions.	NA	Belongs to the type-B carboxylesterase/lipase family.	Cell adhesion molecules (CAMs);Neurexins and neuroligins	PE1	X
+NX_Q8N0W5	IQ domain-containing protein K	287	33292	8.49	0	Nucleus;Nucleus speckle;Nucleolus;Cytosol	NA	NA	NA	NA	NA	PE1	16
+NX_Q8N0W7	Fragile X mental retardation 1 neighbor protein	255	29241	9.19	2	Membrane	NA	NA	NA	NA	NA	PE1	X
+NX_Q8N0X2	Sperm-associated antigen 16 protein	631	70818	5.9	0	Cytoplasm;Flagellum axoneme;Cell membrane;Cilium axoneme;Flagellum;Cytosol	NA	Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity).	Phosphorylated by TSSK2.;SPAG16 is phosphorylated by TSSK2	NA	NA	PE1	2
+NX_Q8N0X4	Citramalyl-CoA lyase, mitochondrial	340	37359	8.88	0	Cytosol;Mitochondrion	NA	Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:29056341, PubMed:24334609). Also displays malyl-CoA thioesterase activity (PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341).	NA	Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily.	NA	PE1	13
+NX_Q8N0X7	Spartin	666	72833	5.66	0	Cytoplasm;Cytosol;Midbody;Cell membrane	Spastic paraplegia 20, autosomal recessive	May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964).	Ubiquitinated; ubiquitination does not require ITCH and WWP1.	NA	NA	PE1	13
+NX_Q8N0Y2	Zinc finger protein 444	327	35204	8.9	0	Nucleoplasm;Nucleus;Nucleolus	NA	Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8N0Y3	Olfactory receptor 4N4	316	35724	9.03	7	Centrosome;Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	15
+NX_Q8N0Y5	Olfactory receptor 8I2	310	34661	8.56	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8N0Y7	Probable phosphoglycerate mutase 4	254	28777	6.19	0	NA	NA	NA	NA	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.	Glycolysis / Gluconeogenesis;Metabolic pathways	PE1	X
+NX_Q8N0Z2	Actin-binding Rho-activating protein	381	43117	8.7	0	Sarcomere;Cytoskeleton	NA	Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.	NA	NA	NA	PE1	8
+NX_Q8N0Z3	Spindle and centriole-associated protein 1	855	96264	7.03	0	Spindle;Centrosome;Centriole	NA	Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.	NA	NA	NA	PE1	3
+NX_Q8N0Z6	Tetratricopeptide repeat protein 5	440	48928	6.05	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).	Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.	NA	Regulation of TP53 Activity through Methylation	PE1	14
+NX_Q8N0Z8	tRNA pseudouridine synthase-like 1	303	33233	9.89	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the tRNA pseudouridine synthase TruA family.	NA	PE1	1
+NX_Q8N0Z9	V-set and immunoglobulin domain-containing protein 10	540	59217	4.62	1	Membrane;Cytosol;Centriolar satellite;Cell membrane	NA	NA	NA	NA	NA	PE1	12
+NX_Q8N100	Protein atonal homolog 7	152	16871	9.61	0	Nucleus	Persistent hyperplastic primary vitreous, autosomal recessive	Transcription factor involved in the differentiation of retinal ganglion cells.	NA	NA	NA	PE1	10
+NX_Q8N103	T-cell activation Rho GTPase-activating protein	731	80703	6.04	0	Cytosol	NA	May function as a GTPase-activating protein and may play important roles during T-cell activation.	NA	NA	Rho GTPase cycle	PE1	6
+NX_Q8N104	Beta-defensin 106	65	7369	8.96	0	Membrane;Secreted	NA	Has antibacterial activity (PubMed:12600824). Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:23938203).	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	8
+NX_Q8N108	Mesoderm induction early response protein 1	512	57983	4.34	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.	NA	NA	NA	PE1	1
+NX_Q8N109	Killer cell immunoglobulin-like receptor 2DL5A	375	40678	8.36	1	Cell membrane	NA	Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.	NA	Belongs to the immunoglobulin superfamily.	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Graft-versus-host disease	PE3	19
+NX_Q8N111	Cell cycle exit and neuronal differentiation protein 1	149	14954	9.24	1	Membrane;Mitochondrion	NA	Involved in neuronal differentiation.	NA	Belongs to the CEND1 family.	NA	PE1	11
+NX_Q8N112	Leucine-rich single-pass membrane protein 2	164	17868	5.69	1	Membrane	NA	NA	NA	NA	NA	PE1	3
+NX_Q8N114	Protein shisa-5	240	25582	6.26	1	Endoplasmic reticulum membrane;Nucleus membrane	NA	Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.	NA	Belongs to the shisa family.	p53 signaling pathway;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	3
+NX_Q8N118	Cytochrome P450 4X1	509	58875	8.74	1	Microsome membrane;Endoplasmic reticulum membrane	NA	NA	NA	Belongs to the cytochrome P450 family.	NA	PE1	1
+NX_Q8N119	Matrix metalloproteinase-21	569	65043	9.19	0	Secreted	Heterotaxy, visceral, 7, autosomal	Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721).	The precursor is cleaved by a furin endopeptidase.	Belongs to the peptidase M10A family.	NA	PE2	10
+NX_Q8N122	Regulatory-associated protein of mTOR	1335	149038	6.43	0	Cytoplasmic vesicle;Cytoplasm;Cytoplasmic granule;Lysosome	NA	Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. MTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. MTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). MTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.	Insulin-stimulated phosphorylation at Ser-863 by MTOR and MAPK8 up-regulates mTORC1 activity. Osmotic stress also induces phosphorylation at Ser-696, Thr-706 and Ser-863 by MAPK8. Ser-863 phosphorylation is required for phosphorylation at Ser-855 and Ser-859. In response to nutrient limitation, phosphorylated by AMPK; phosphorylation promotes interaction with 14-3-3 proteins, leading to negative regulation of the mTORC1 complex. In response to growth factors, phosphorylated at Ser-719, Ser-721 and Ser-722 by RPS6KA1, which stimulates mTORC1 activity.;RPTOR is phosphorylated by RPS6KA2 (Phosphoserine:PTM-0253);RPTOR is phosphorylated by ULK2	Belongs to the WD repeat RAPTOR family.	mTOR signaling pathway;Insulin signaling pathway;Macroautophagy;HSF1-dependent transactivation;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;mTOR signalling;mTORC1-mediated signalling;Regulation of PTEN gene transcription	PE1	17
+NX_Q8N123	CPX chromosomal region candidate gene 1 protein	301	34727	8.9	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_Q8N126	Cell adhesion molecule 3	398	43300	5.71	1	Cytosol;Cell junction;Cell membrane	NA	Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).	NA	Belongs to the nectin family.	Cell adhesion molecules (CAMs);Adherens junctions interactions;Nectin/Necl trans heterodimerization	PE1	1
+NX_Q8N127	Olfactory receptor 5AS1	324	36653	8.63	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8N128	Protein FAM177A1	213	23757	4.4	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the FAM177 family.	NA	PE1	14
+NX_Q8N129	Protein canopy homolog 4	248	28310	4.6	0	Cytoplasmic vesicle;Secreted	NA	Plays a role in the regulation of the cell surface expression of TLR4.	NA	Belongs to the canopy family.	NA	PE1	7
+NX_Q8N130	Sodium-dependent phosphate transport protein 2C	599	63550	8.62	8	Membrane	Hereditary hypophosphatemic rickets with hypercalciuria	May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.	NA	Belongs to the SLC34A transporter family.	Type II Na+/Pi cotransporters;Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)	PE1	9
+NX_Q8N131	Porimin	208	21531	8.76	1	Golgi apparatus;Cell membrane;Membrane;Cytoplasmic vesicle;Cytosol	NA	Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.	NA	Belongs to the CD164 family.	NA	PE1	11
+NX_Q8N135	Leucine-rich repeat LGI family member 4	537	59141	7.28	0	Golgi apparatus;Secreted	Arthrogryposis multiplex congenita, neurogenic, with myelin defect	Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity).	NA	NA	LGI-ADAM interactions	PE1	19
+NX_Q8N136	Dynein assembly factor with WDR repeat domains 1	415	45777	6.12	0	Nucleoplasm;Cilium;Nucleus;Cell membrane	NA	May play a role in axonemal outer row dynein assembly.	NA	Belongs to the WD repeat WDR69 family.	NA	PE1	2
+NX_Q8N137	Centrobin	903	101253	5.41	0	Cytosol;Centrosome;Centriole	NA	Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.	CNTROB is phosphorylated by NEK2	NA	NA	PE1	17
+NX_Q8N138	ORM1-like protein 3	153	17495	9.64	2	Endoplasmic reticulum membrane	Asthma	Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.	NA	Belongs to the ORM family.	Sphingolipid de novo biosynthesis;Neutrophil degranulation	PE1	17
+NX_Q8N139	ATP-binding cassette sub-family A member 6	1617	184286	7.05	14	Membrane;Nucleoplasm	NA	Probable transporter which may play a role in macrophage lipid homeostasis.	NA	Belongs to the ABC transporter superfamily. ABCA family.	ABC transporters;ABC transporters in lipid homeostasis;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	17
+NX_Q8N140	EP300-interacting inhibitor of differentiation 3	333	38168	5.03	0	Cytoplasm;Nucleolus;Nucleoplasm;Telomere;Nucleus	NA	Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.;Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.	NA	Belongs to the NSE4 family.	SUMOylation of DNA damage response and repair proteins	PE1	12
+NX_Q8N141	Zinc finger protein 82 homolog	532	62578	9.2	0	Nucleoplasm;Cytosol;Nucleus membrane;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8N142	Adenylosuccinate synthetase isozyme 1	457	50208	8.76	0	Cytoplasm	Myopathy, distal, 5	Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.	NA	Belongs to the adenylosuccinate synthetase family.	Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.;Purine metabolism;Alanine, aspartate and glutamate metabolism;Metabolic pathways;Purine ribonucleoside monophosphate biosynthesis	PE1	14
+NX_Q8N143	B-cell CLL/lymphoma 6 member B protein	479	51531	9.23	0	Cytoplasmic vesicle;Nucleus	NA	Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.	NA	NA	NA	PE1	17
+NX_Q8N144	Gap junction delta-3 protein	294	31933	8.94	4	Gap junction;Cell membrane	NA	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Delta-type subfamily.	Gap junction assembly	PE1	17
+NX_Q8N145	Leucine-rich repeat LGI family member 3	548	61704	8.15	0	Cytosol;Secreted;Synaptic vesicle;Synaptosome	NA	May participate in the regulation of neuronal exocytosis.	NA	NA	LGI-ADAM interactions	PE1	8
+NX_Q8N146	Olfactory receptor 8H3	312	35219	8.53	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8N148	Olfactory receptor 6V1	313	34902	8.32	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_Q8N149	Leukocyte immunoglobulin-like receptor subfamily A member 2	483	52992	6.43	1	Secreted;Cell membrane	NA	Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061).	NA	NA	Osteoclast differentiation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q8N157	Jouberin	1196	137115	6.67	0	Cytoplasm;Centriole;Adherens junction;Cilium basal body;Centrosome	Joubert syndrome 3	Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382).	NA	NA	Anchoring of the basal body to the plasma membrane	PE1	6
+NX_Q8N158	Glypican-2	579	62830	8.33	0	Endoplasmic reticulum;Extracellular space;Cell membrane	NA	Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).	NA	Belongs to the glypican family.	Retinoid metabolism and transport;HS-GAG biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	7
+NX_Q8N159	N-acetylglutamate synthase, mitochondrial	534	58156	9.12	0	Mitochondrion matrix;Mitochondrion	N-acetylglutamate synthase deficiency	Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity.	Probably processed by mitochondrial processing peptidase (MPP). The long form has not yet been isolated (By similarity).	Belongs to the acetyltransferase family.	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.;Arginine and proline metabolism;Metabolic pathways;Urea cycle	PE1	17
+NX_Q8N162	Olfactory receptor 8H2	312	35422	9.03	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8N163	Cell cycle and apoptosis regulator protein 2	923	102902	5.14	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978).	ATM/ATR-mediated phosphorylation at Thr-454 upon DNA damage promotes binding to SIRT1. Phosphorylation at Thr-454 promotes its sumoylation by switching the binding partner of CCAR2 from SENP1 to PIAS3.;Acetylation at Lys-112 and Lys-215 by KAT8 prevents inhibitory binding to SIRT1 and increases its deacetylase activity.;Genotoxic stress induces its sumoylation and sumoylation promotes the SIRT1-CCAR2 interaction which in turn inhibits SIRT1-mediated deacetylation of p53/TP53. Sumoylation leads to transcriptional activation of p53/TP53 by sequestering SIRT1 from p53/TP53. Desumoylated by SENP1.	NA	Regulation of HSF1-mediated heat shock response	PE1	8
+NX_Q8N165	Serine/threonine-protein kinase PDIK1L	341	38546	6.42	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	1
+NX_Q8N183	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2	169	19856	8.94	0	Mitochondrion	Mitochondrial complex I deficiency, nuclear type 10	Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371).	NA	Belongs to the complex I NDUFA12 subunit family.	Complex I biogenesis	PE1	5
+NX_Q8N184	Zinc finger protein 567	647	75164	9.3	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8N187	Calcium-responsive transcription factor	725	80698	5.47	0	Nucleus;Cytosol;Nucleolus;Cytoplasmic vesicle	NA	Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence.	NA	NA	NA	PE1	2
+NX_Q8N196	Homeobox protein SIX5	739	74562	4.93	0	Cytoplasm;Nucleus	Branchiootorenal syndrome 2	Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity).	NA	Belongs to the SIX/Sine oculis homeobox family.	NA	PE1	19
+NX_Q8N1A0	Keratin-like protein KRT222	295	34158	5.63	0	Cytoplasmic vesicle;Lipid droplet	NA	NA	NA	Belongs to the intermediate filament family.	NA	PE1	17
+NX_Q8N1A6	UPF0462 protein C4orf33	199	23468	5.27	0	Golgi apparatus;Nucleus	NA	NA	NA	Belongs to the UPF0462 family.	NA	PE1	4
+NX_Q8N1B3	Cyclin-Q	248	28369	5.84	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Toe syndactyly, telecanthus, and anogenital and renal malformations	Activating cyclin for the cyclin-associated kinase CDK10.	NA	Belongs to the cyclin family. Cyclin-like FAM58 subfamily.	NA	PE1	X
+NX_Q8N1B4	Vacuolar protein sorting-associated protein 52 homolog	723	82221	5.7	0	Recycling endosome;trans-Golgi network membrane;Endosome membrane	NA	Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).	NA	Belongs to the VPS52 family.	Retrograde transport at the Trans-Golgi-Network	PE1	6
+NX_Q8N1C3	Gamma-aminobutyric acid receptor subunit gamma-1	465	53595	8.39	4	Cell membrane;Postsynaptic cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	May be palmitoylated.	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG1 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse	PE1	4
+NX_Q8N1D0	Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein	253	27061	9.87	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE2	11
+NX_Q8N1D5	Uncharacterized protein C1orf158	194	23067	9.73	0	Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q8N1E2	Lysozyme g-like protein 1	194	21431	8.47	0	Secreted	NA	NA	NA	Belongs to the glycosyl hydrolase 23 family.	NA	PE2	2
+NX_Q8N1E6	F-box/LRR-repeat protein 14	418	45886	9.15	0	Golgi apparatus;Cytoplasm;Cytosol;Nucleoplasm	NA	Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	12
+NX_Q8N1F7	Nuclear pore complex protein Nup93	819	93488	5.5	0	Nucleus;Nucleus envelope;Nucleus membrane;Nuclear pore complex	Nephrotic syndrome 12	Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725).	NA	Belongs to the nucleoporin interacting component (NIC) family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	16
+NX_Q8N1F8	Serine/threonine-protein kinase 11-interacting protein	1088	120259	5.24	0	Cytoplasmic vesicle;Cytoplasm	NA	May regulate STK11/LKB1 function by controlling its subcellular localization.	NA	Belongs to the STK11IP family.	Neutrophil degranulation	PE1	2
+NX_Q8N1G0	Zinc finger protein 687	1237	129529	8.56	0	Cytoplasm;Nucleoplasm;Nucleus	Paget disease of bone 6	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_Q8N1G1	RNA exonuclease 1 homolog	1221	131510	9.12	0	Nucleoplasm;Nucleus	NA	Seems to have no detectable effect on transcription elongation in vitro.	NA	Belongs to the REXO1/REXO3 family.	Ribosome biogenesis in eukaryotes	PE1	19
+NX_Q8N1G2	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1	835	95321	6.64	0	Nucleoplasm;Cytosol;Nucleus	NA	S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.	NA	NA	NA	PE1	6
+NX_Q8N1G4	Leucine-rich repeat-containing protein 47	583	63473	8.55	0	Nucleolus	NA	NA	NA	NA	NA	PE1	1
+NX_Q8N1H7	Protein SIX6OS1	587	68166	5.39	0	Nucleoplasm;Nucleolus;Chromosome	NA	Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination. Required for the appropriate processing of intermediate recombination nodules before crossover formation.	NA	NA	NA	PE1	14
+NX_Q8N1I0	Dedicator of cytokinesis protein 4	1966	225206	7.57	0	Golgi apparatus;Cell membrane;Cell projection;Nucleolus;Cytosol	NA	Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.	NA	Belongs to the DOCK family.	Factors involved in megakaryocyte development and platelet production	PE1	7
+NX_Q8N1I8	Putative uncharacterized protein encoded by CACTIN-AS1	211	22698	6.31	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_Q8N1K5	Protein THEMIS	641	73452	5.62	0	Cytoplasm;Nucleus	NA	Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.	Phosphorylated on Tyr residues quickly after TCR stimulation.	Belongs to the themis family.	NA	PE1	6
+NX_Q8N1L1	Putative uncharacterized protein encoded by LINC00528	170	18115	6.03	0	NA	NA	NA	NA	NA	NA	PE5	22
+NX_Q8N1L4	Putative inactive cytochrome P450 family member 4Z2	340	40159	9.25	1	Membrane	NA	NA	NA	Belongs to the cytochrome P450 family.	NA	PE5	1
+NX_Q8N1L9	Basic leucine zipper transcriptional factor ATF-like 2	274	29398	7.2	0	Nucleolus;Nucleus	NA	AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter.	NA	Belongs to the bZIP family.	NA	PE1	11
+NX_Q8N1M1	Bestrophin-3	668	76107	6.13	4	Cytoplasm;Cell membrane	NA	Forms calcium-sensitive chloride channels. Permeable to bicarbonate.	NA	Belongs to the bestrophin family.	Stimuli-sensing channels	PE2	12
+NX_Q8N1N0	C-type lectin domain family 4 member F	589	65519	6.23	1	Membrane	NA	Receptor with an affinity for galactose and fucose. Could be involved in endocytosis (By similarity).	NA	NA	NA	PE2	2
+NX_Q8N1N2	Dynactin-associated protein	210	22529	5.27	1	Golgi apparatus membrane;Cell membrane	NA	Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'.	NA	NA	NA	PE1	18
+NX_Q8N1N4	Keratin, type II cytoskeletal 78	520	56866	5.79	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q8N1N5	Cysteine-rich PAK1 inhibitor	446	48076	8.42	0	Membrane;Cytoplasm;Nucleus	NA	Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence.	NA	NA	NA	PE1	4
+NX_Q8N1P7	Beta/gamma crystallin domain-containing protein 2	1661	177913	5.74	0	Nucleoplasm	NA	NA	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	1
+NX_Q8N1Q1	Carbonic anhydrase 13	262	29443	6.45	0	Nucleoplasm;Nucleolus;Cytoplasmic vesicle	NA	Reversible hydration of carbon dioxide.	NA	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Reversible hydration of carbon dioxide	PE1	8
+NX_Q8N1Q8	Acyl-coenzyme A thioesterase THEM5	247	27677	7.61	0	Mitochondrion matrix	NA	Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (PubMed:22586271). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271). Required for normal mitochondrial function (PubMed:22586271).	NA	Belongs to the THEM4/THEM5 thioesterase family.	Mitochondrial Fatty Acid Beta-Oxidation	PE1	1
+NX_Q8N1S5	Zinc transporter ZIP11	342	35396	5.44	7	Golgi apparatus;Cytoplasm;Cell membrane;Nucleoplasm;Nucleus	NA	Functions as a cellular zinc transporter.	NA	Belongs to the ZIP transporter (TC 2.A.5) family.	NA	PE1	17
+NX_Q8N1T3	Unconventional myosin-Ih	1032	119037	9.19	0	NA	NA	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	12
+NX_Q8N1V2	Cilia- and flagella-associated protein 52	620	68298	6.51	0	Cytoplasm;Flagellum	NA	May play a role in cell growth and/or survival.	NA	Belongs to the CFAP52 family.	NA	PE1	17
+NX_Q8N1V8	Uncharacterized protein encoded by LINC01561	128	13299	7.66	0	NA	NA	NA	NA	NA	NA	PE5	10
+NX_Q8N1W1	Rho guanine nucleotide exchange factor 28	1705	191891	5.69	0	Cytoplasm;Cytosol;Cytoskeleton;Cell membrane	NA	Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).	Phosphorylated on tyrosine upon stimulation of cells by laminin.	NA	EPHB-mediated forward signaling	PE1	5
+NX_Q8N1W2	Zinc finger protein 710	664	74461	6.33	0	Nucleoplasm;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	15
+NX_Q8N1X5	Uncharacterized protein FLJ37310	172	16487	12.11	0	NA	NA	NA	NA	NA	NA	PE2	6
+NX_Q8N1Y9	Putative uncharacterized protein FLJ37218	231	24915	6.89	1	Membrane	NA	NA	NA	NA	NA	PE5	9
+NX_Q8N201	Integrator complex subunit 1	2190	244297	5.77	1	Nucleoplasm;Nucleus membrane	NA	Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).	NA	Belongs to the Integrator subunit 1 family.	RNA polymerase II transcribes snRNA genes	PE1	7
+NX_Q8N205	Nesprin-4	404	43512	5.48	1	Nucleus outer membrane	Deafness, autosomal recessive, 76	As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity).	The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces.	Belongs to the nesprin family.	NA	PE1	19
+NX_Q8N228	Sex comb on midleg-like protein 4	414	45023	9.78	0	Nucleoplasm;Nucleus	NA	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).	NA	Belongs to the SCM family.	NA	PE1	6
+NX_Q8N239	Kelch-like protein 34	644	70612	5.41	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_Q8N257	Histone H2B type 3-B	126	13908	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.;GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	1
+NX_Q8N264	Rho GTPase-activating protein 24	748	84258	6.24	0	Cell membrane;Adherens junction;Focal adhesion;Cell projection;Cytosol;Cytoskeleton	NA	Is a vascular cell-specific GAP involved in modulation of angiogenesis.;Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia.	Phosphorylated by ROCK, leading to activate the RacGAP activity.	NA	Rho GTPase cycle	PE1	4
+NX_Q8N268	Uncharacterized protein C20orf197	126	14459	9.37	0	NA	NA	NA	NA	NA	NA	PE2	20
+NX_Q8N271	Prominin-2	834	91883	5.8	5	Cell membrane;Basolateral cell membrane;Cell junction;Microvillus membrane;Nucleoplasm;Cilium membrane;Apical cell membrane	NA	NA	Glycosylated.	Belongs to the prominin family.	NA	PE1	2
+NX_Q8N283	Ankyrin repeat domain-containing protein 35	1001	109966	5.76	0	Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q8N292	Protein GAPT	157	17883	8.67	1	Cell membrane	NA	Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity).	NA	Belongs to the GAPT family.	NA	PE1	5
+NX_Q8N2A0	Putative uncharacterized protein encoded by LINC00269	174	18329	6.74	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_Q8N2A8	Mitochondrial cardiolipin hydrolase	252	28273	9.53	1	Mitochondrion outer membrane	NA	Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. PiRNAs provide essential protection against the activity of mobile genetic elements (By similarity). PiRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579, PubMed:26711011).	NA	Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.	PIWI-interacting RNA (piRNA) biogenesis;Synthesis of PA;Synthesis of PG	PE1	17
+NX_Q8N2B8	Putative uncharacterized protein FLJ33534	174	19079	11.57	0	NA	NA	NA	NA	NA	NA	PE2	2
+NX_Q8N2C3	DEP domain-containing protein 4	294	33694	6.71	0	Cytoskeleton	NA	NA	NA	NA	NA	PE2	12
+NX_Q8N2C7	Protein unc-80 homolog	3258	363390	6.4	4	Membrane;Cytoplasmic vesicle;Nucleus	Hypotonia, infantile, with psychomotor retardation and characteristic facies 2	Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium.	Phosphorylated on tyrosine residues.	Belongs to the unc-80 family.	Stimuli-sensing channels	PE1	2
+NX_Q8N2C9	Uncharacterized protein UMODL1-AS1	162	18019	7.18	0	NA	NA	NA	NA	NA	NA	PE2	21
+NX_Q8N2E2	von Willebrand factor D and EGF domain-containing protein	1590	176780	5.42	0	Nucleoplasm;Cytosol;Secreted	NA	NA	NA	NA	NA	PE1	7
+NX_Q8N2E6	Prosalusin	242	26262	10.17	0	Secreted	NA	Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides.	Amidation of salusin-alpha(29-Gly) by peptidylglycine alpha-amidating monooxygenase, PAM, converts Lys-241-Gly-242 to Lys-241-NH2 and gives raise to salusin-alpha.	Belongs to the ClpA/ClpB family. Torsin subfamily.	NA	PE1	9
+NX_Q8N2F6	Armadillo repeat-containing protein 10	343	37540	6.16	1	Endoplasmic reticulum membrane;Mitochondrion	NA	May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.	NA	NA	NA	PE1	7
+NX_Q8N2G4	Ly6/PLAUR domain-containing protein 1	141	15240	8.4	0	Endoplasmic reticulum;Cell membrane	NA	Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety.	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	2
+NX_Q8N2G6	Zinc finger CCHC domain-containing protein 24	241	26955	8.97	0	Nucleoplasm;Mitochondrion	NA	NA	NA	NA	NA	PE1	10
+NX_Q8N2G8	GH3 domain-containing protein	530	57523	8.05	0	Endoplasmic reticulum;Nucleus envelope	NA	NA	Methylated at Gln-489 by N6AMT1.	Belongs to the GH3 family.	Neutrophil degranulation	PE1	17
+NX_Q8N2H3	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2	581	63068	6.47	0	Mitochondrion	NA	Probable oxidoreductase.	NA	Belongs to the carotenoid/retinoid oxidoreductase family.	NA	PE1	10
+NX_Q8N2H4	Protein SYS1 homolog	156	17615	7.62	4	Golgi apparatus membrane	NA	Involved in protein trafficking. May serve as a receptor for ARFRP1.	NA	Belongs to the SYS1 family.	Retrograde transport at the Trans-Golgi-Network	PE1	20
+NX_Q8N2H9	E3 ubiquitin-protein ligase pellino homolog 3	469	50755	7.24	0	Nucleoplasm;Nucleolus;Cytoplasmic vesicle	NA	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.	Phosphorylated by IRAK1 enhancing its E3 ligase activity.;PELI3 is phosphorylated by IRAK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the pellino family.	Protein modification; protein ubiquitination.;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Interleukin-1 signaling	PE1	11
+NX_Q8N2I2	Zinc finger protein 619	560	63322	8.72	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	3
+NX_Q8N2I9	Serine/threonine-protein kinase 40	435	49001	8.04	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	1
+NX_Q8N2K0	Lysophosphatidylserine lipase ABHD12	398	45097	8.87	1	Endoplasmic reticulum membrane	Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract	Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30720278, PubMed:30643283). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167).	Glycosylated; glycosylation is required for optimal activity.	Belongs to the serine esterase family.	Arachidonate production from DAG	PE1	20
+NX_Q8N2K1	Ubiquitin-conjugating enzyme E2 J2	259	28898	8.6	1	Endoplasmic reticulum membrane	NA	Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).	Auto-ubiquitinated.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Parkinson's disease;Antigen processing: Ubiquitination &amp; Proteasome degradation;E3 ubiquitin ligases ubiquitinate target proteins;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	1
+NX_Q8N2M4	Lysoplasmalogenase-like protein TMEM86A	240	26398	8.92	7	Membrane;Golgi apparatus;Nucleoplasm	NA	NA	NA	Belongs to the TMEM86 family.	NA	PE2	11
+NX_Q8N2M8	CLK4-associating serine/arginine rich protein	674	77161	10.44	0	Nucleoplasm;Nucleus	NA	Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).	Phosphorylated in vitro by CLK4.;CLASRP is phosphorylated by CLK4	Belongs to the splicing factor SR family.	NA	PE1	19
+NX_Q8N2N9	Ankyrin repeat domain-containing protein 36B	1353	153582	9.01	0	NA	NA	NA	NA	Belongs to the ANKRD36 family.	NA	PE1	2
+NX_Q8N2Q7	Neuroligin-1	863	96368	5.94	1	Nucleus;Postsynaptic density;Synaptic cleft;Cell membrane	NA	Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.	NA	Belongs to the type-B carboxylesterase/lipase family.	Cell adhesion molecules (CAMs);Neurexins and neuroligins	PE1	3
+NX_Q8N2R0	Protein odd-skipped-related 2	312	35513	9.66	0	Nucleoplasm;Nucleus;Cell membrane	NA	NA	NA	Belongs to the Odd C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_Q8N2R8	Protein FAM43A	423	45776	6.1	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the FAM43 family.	NA	PE1	3
+NX_Q8N2S1	Latent-transforming growth factor beta-binding protein 4	1624	173435	5.27	0	Extracellular matrix	Urban-Rifkin-Davis syndrome;Duchenne muscular dystrophy	Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.	Contains hydroxylated asparagine residues.	Belongs to the LTBP family.	Molecules associated with elastic fibres	PE1	19
+NX_Q8N2U0	Transmembrane protein 256	113	11742	9.1	2	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the TMEM256 family.	NA	PE1	17
+NX_Q8N2U9	Solute carrier family 66 member 2	271	30478	8.34	6	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	18
+NX_Q8N2W9	E3 SUMO-protein ligase PIAS4	510	56504	5.84	0	Nucleoplasm;PML body	NA	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.	Sumoylated. Lys-35 is the main site of sumoylation. Sumoylation is required for TCF4 sumoylation and transcriptional activation. Represses LEF1 transcriptional activity. SUMO1 is the preferred conjugate.	Belongs to the PIAS family.	Protein modification; protein sumoylation.;Ubiquitin mediated proteolysis;Jak-STAT signaling pathway;Hepatitis C;Pathways in cancer;Small cell lung cancer;SUMOylation of DNA damage response and repair proteins;G2/M DNA damage checkpoint;Vitamin D (calciferol) metabolism;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);SUMOylation of DNA replication proteins;SUMOylation of transcription factors;SUMOylation of intracellular receptors;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins;SUMOylation of transcription cofactors;SUMOylation of immune response proteins	PE1	19
+NX_Q8N2X6	Uncharacterized protein EXOC3-AS1	119	12661	11.04	0	Secreted	NA	NA	NA	NA	NA	PE1	5
+NX_Q8N2Y8	Iporin	1516	161225	6.17	0	Cytosol	Mental retardation, autosomal recessive 61	NA	NA	NA	NA	PE1	9
+NX_Q8N2Z9	Centromere protein S	138	15893	5.83	0	Kinetochore;Centromere;Nucleus	NA	DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM (PubMed:20347428, PubMed:20347429). In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428). In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:22304917). DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347428, PubMed:20347429).	NA	Belongs to the TAF9 family. CENP-S/MHF1 subfamily.	Fanconi anemia pathway;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Fanconi Anemia Pathway	PE1	1
+NX_Q8N300	Small vasohibin-binding protein	66	7808	9.21	0	Cytoplasm;Secreted;Nucleoplasm;Cytosol;Nucleus	NA	Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017).	NA	Belongs to the SVBP family.	NA	PE1	1
+NX_Q8N302	Angiogenic factor with G patch and FHA domains 1	714	80977	5.29	0	Cytoplasm;Secreted	Klippel-Trenaunay syndrome	Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.	NA	NA	Signaling by BRAF and RAF fusions	PE1	5
+NX_Q8N307	Mucin-20	709	71982	4.95	0	Cell membrane;Basolateral cell membrane;Secreted;Microvillus membrane;Nucleoplasm;Cytosol;Apical cell membrane	NA	May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.	NA	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);MET activates RAS signaling	PE1	3
+NX_Q8N309	Leucine-rich repeat-containing protein 43	656	73022	5.17	0	Golgi apparatus;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	12
+NX_Q8N319	Uncharacterized protein C6orf223	242	26113	12.2	0	Nucleolus	NA	NA	NA	NA	NA	PE2	6
+NX_Q8N323	NXPE family member 1	547	63178	8.78	0	Secreted	NA	NA	NA	Belongs to the NXPE family.	NA	PE1	11
+NX_Q8N326	Uncharacterized protein C10orf111	155	17766	10.01	1	Membrane	NA	NA	NA	NA	NA	PE2	10
+NX_Q8N328	PiggyBac transposable element-derived protein 3	593	67595	7.81	0	Nucleus	NA	Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.	NA	NA	NA	PE1	10
+NX_Q8N335	Glycerol-3-phosphate dehydrogenase 1-like protein	351	38419	6.61	0	Cytoplasm	Brugada syndrome 2	Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.	NA	Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.	Glycerophospholipid metabolism;Synthesis of PA	PE1	3
+NX_Q8N336	ELMO domain-containing protein 1	334	39052	8.78	0	Nucleoplasm;Cytosol	NA	Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.	NA	NA	NA	PE1	11
+NX_Q8N339	Metallothionein-1M	61	6110	8.05	0	NA	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	NA	Belongs to the metallothionein superfamily. Type 1 family.	Mineral absorption;Metallothioneins bind metals	PE1	16
+NX_Q8N344	Mesoderm induction early response protein 2	545	59944	4.53	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional repressor.	NA	NA	NA	PE1	19
+NX_Q8N349	Olfactory receptor 2L13	312	35634	9.09	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	705	73929	5.96	1	Growth cone;Nucleoplasm;Synaptic vesicle membrane;Cell membrane	NA	Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.	NA	NA	NA	PE1	19
+NX_Q8N357	Solute carrier family 35 member F6	371	40214	6.44	9	Mitochondrion;Lysosome membrane;Nucleoplasm;Endosome;Cytoplasmic vesicle;Cytosol	NA	Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.	NA	Belongs to the SLC35F solute transporter family.	NA	PE1	2
+NX_Q8N365	Circadian-associated transcriptional repressor	385	41443	9.49	0	Nucleoplasm;Nucleus;PML body	NA	Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).	NA	NA	NA	PE1	1
+NX_Q8N370	Large neutral amino acids transporter small subunit 4	569	62747	8.25	12	Membrane;Golgi apparatus;Cell membrane	NA	Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids.	Glycosylated.	Belongs to the SLC43A transporter (TC 2.A.1.44) family.	Amino acid transport across the plasma membrane	PE1	17
+NX_Q8N371	Bifunctional peptidase and arginyl-hydroxylase JMJD5	416	47270	5.51	0	Nucleoplasm;Cytosol;Nucleus;Chromosome	NA	Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961, PubMed:29459673, PubMed:28982940, PubMed:29563586). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961, PubMed:29459673, PubMed:28982940). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961, PubMed:29459673). Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established (PubMed:29563586). Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition (PubMed:24740926). Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation (PubMed:20457893). Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (PubMed:28455245). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a catalytically-independent manner (PubMed:30500822). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822).	NA	NA	NA	PE1	16
+NX_Q8N377	Putative uncharacterized protein LOC387726	158	15598	7.64	0	NA	NA	NA	NA	NA	NA	PE5	10
+NX_Q8N386	Leucine-rich repeat-containing protein 25	305	33179	4.88	1	Membrane;Cytoplasm	NA	Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164). Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.	NA	NA	NA	PE1	19
+NX_Q8N387	Mucin-15	334	36294	4.93	1	Secreted;Cell membrane	NA	May play a role in the cell adhesion to the extracellular matrix.	Highly glycosylated (N- and O-linked carbohydrates).	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	11
+NX_Q8N392	Rho GTPase-activating protein 18	663	74977	6.1	0	Cytoplasm;Cytosol;Nucleus speckle;Cell membrane	NA	Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595).	NA	NA	Rho GTPase cycle	PE1	6
+NX_Q8N393	Zinc finger protein 786	782	89815	9.39	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q8N394	Protein O-mannosyl-transferase TMTC2	836	94130	8.94	10	Membrane;Endoplasmic reticulum;Cell membrane;Cytoskeleton	NA	Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.	NA	Belongs to the TMTC family.	Protein modification; protein glycosylation.	PE1	12
+NX_Q8N398	von Willebrand factor A domain-containing protein 5B2	1242	131668	6.02	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	NA	NA	PE1	3
+NX_Q8N3A8	Protein mono-ADP-ribosyltransferase PARP8	854	95871	8.58	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Midbody ring	NA	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.	Auto-mono-ADP-ribosylated.	NA	Nicotinamide salvaging	PE1	5
+NX_Q8N3C0	Activating signal cointegrator 1 complex subunit 3	2202	251460	6.64	0	Golgi apparatus;Cytoplasm;Nucleus speckle;Cytosol;Nucleus	NA	3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).	NA	Belongs to the helicase family.	ALKBH3 mediated reversal of alkylation damage	PE1	6
+NX_Q8N3C7	CAP-Gly domain-containing linker protein 4	705	76317	8.93	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	2
+NX_Q8N3D4	EH domain-binding protein 1-like protein 1	1523	161854	4.8	0	Endosome	NA	May act as Rab effector protein and play a role in vesicle trafficking.	Prenylated (Probable). Farnelysation (predominant) and geranylgeranylation has been observed in vitro.	NA	NA	PE1	11
+NX_Q8N3E9	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	789	89258	6.52	0	Membrane;Cytoplasm;Cleavage furrow;Cell membrane	NA	Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Phosphatidylinositol signaling system;Synthesis of IP3 and IP4 in the cytosol	PE1	17
+NX_Q8N3F0	Maturin	131	14925	4.03	0	Cytosol	NA	May be involved in early neuronal development.	NA	Belongs to the MTURN family.	NA	PE1	7
+NX_Q8N3F8	MICAL-like protein 1	863	93441	6.88	0	Cell junction;Centriolar satellite;Recycling endosome membrane;Cytosol;Late endosome membrane	NA	Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.	NA	NA	NA	PE1	22
+NX_Q8N3F9	Integral membrane protein GPR137C	429	47075	7.16	7	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the GPR137 family.	NA	PE2	14
+NX_Q8N3G9	Transmembrane protein 130	435	48329	6.07	1	Endoplasmic reticulum;Golgi apparatus;Golgi apparatus membrane	NA	NA	NA	NA	NA	PE1	7
+NX_Q8N3H0	Chemokine-like protein TAFA-2	131	14620	9.46	0	Cytoplasm;Nucleus	NA	Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions.	NA	Belongs to the TAFA family.	NA	PE1	12
+NX_Q8N3I7	Bardet-Biedl syndrome 5 protein	341	38755	5.39	0	Cytoplasm;Centriolar satellite;Cilium basal body;Cilium membrane;Nucleus	Bardet-Biedl syndrome 5	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.	NA	Belongs to the BBS5 family.	BBSome-mediated cargo-targeting to cilium	PE1	2
+NX_Q8N3J2	N(6)-adenine-specific DNA methyltransferase METTL4	472	54041	6.39	0	Mitochondrion	NA	N(6)-adenine-specific DNA methyltransferase that mediates methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) and is required to regulate Polycomb silencing. N(6)-methyladenosine deposition by METTL4 triggers ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing.	NA	Belongs to the MT-A70-like family.	NA	PE1	18
+NX_Q8N3J3	Uncharacterized protein C17orf53	647	69771	5.85	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	17
+NX_Q8N3J5	Protein phosphatase 1K, mitochondrial	372	40997	6.27	0	Mitochondrion matrix;Mitochondrion	Maple syrup urine disease, mild variant	Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.	NA	Belongs to the PP2C family.	Branched-chain amino acid catabolism	PE1	4
+NX_Q8N3J6	Cell adhesion molecule 2	435	47554	5.17	1	Axon;Synapse;Cell membrane	NA	Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.	NA	Belongs to the nectin family.	Adherens junctions interactions	PE1	3
+NX_Q8N3J9	Zinc finger protein 664	261	30284	9.03	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	12
+NX_Q8N3K9	Cardiomyopathy-associated protein 5	4069	449211	4.73	0	Cytoplasm;M line;Sarcoplasmic reticulum;Perinuclear region;Nucleus	NA	May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity).	Phosphorylated by PKA.	NA	NA	PE1	5
+NX_Q8N3L3	Beta-taxilin	684	76519	4.9	0	NA	NA	Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.	NA	Belongs to the taxilin family.	NA	PE1	6
+NX_Q8N3P4	Vacuolar protein sorting-associated protein 8 homolog	1428	161754	5.41	0	Early endosome;Cell membrane;Cytosol	NA	Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290).	NA	Belongs to the VPS8 family.	NA	PE1	3
+NX_Q8N3R3	T-cell activation inhibitor, mitochondrial	496	57925	8.9	0	Mitochondrion	NA	May regulate T-cell apoptosis.	NA	NA	NA	PE1	3
+NX_Q8N3R9	MAGUK p55 subfamily member 5	675	77294	5.77	0	Cytoplasm;Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment;Cell membrane;Endomembrane system;Adherens junction;Perikaryon;Nucleoplasm;Tight junction;Cytosol;Apical cell membrane;Axon	NA	(Microbial infection) Acts as an interaction partner for human SARS coronavirus envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity.;Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation and cerebellar layer organization (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity).	NA	Belongs to the MAGUK family.	Tight junction;Tight junction interactions	PE1	14
+NX_Q8N3S3	Putative homeodomain transcription factor 2	785	88757	9.09	0	Endoplasmic reticulum;Nucleoplasm;Nucleus;Cytosol	NA	May play a role in transcription regulation.	NA	NA	NA	PE1	7
+NX_Q8N3T1	Polypeptide N-acetylgalactosaminyltransferase 15	639	73063	6.44	1	Golgi apparatus;Cytosol;Golgi apparatus membrane	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	3
+NX_Q8N3T6	Transmembrane protein 132C	1108	121787	5.95	1	Membrane;Cytosol;Centrosome	NA	NA	NA	Belongs to the TMEM132 family.	NA	PE1	12
+NX_Q8N3U1	Putative uncharacterized protein LOC400692	123	12695	5.54	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_Q8N3U4	Cohesin subunit SA-2	1231	141326	5.27	0	Centromere;Nucleus;Chromosome	Neurodevelopmental disorder, X-linked, with craniofacial abnormalities	Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.	Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).	Belongs to the SCC3 family.	Cell cycle;Separation of Sister Chromatids;SUMOylation of DNA damage response and repair proteins;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion;Meiotic synapsis;Estrogen-dependent gene expression	PE1	X
+NX_Q8N3V7	Synaptopodin	929	99463	8.92	0	Dendritic spine;Perikaryon;Nucleoplasm;Tight junction;Postsynaptic density;Synapse;Cytosol;Cytoskeleton	NA	Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity).	O-glycosylated.	Belongs to the synaptopodin family.	NA	PE1	5
+NX_Q8N3X1	Formin-binding protein 4	1017	110266	4.68	0	Nucleus speckle	NA	NA	NA	NA	NA	PE1	11
+NX_Q8N3X6	Ligand-dependent nuclear receptor corepressor-like protein	602	66964	8.2	0	Nucleoplasm;Nucleus;Nucleus membrane	NA	May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity).	NA	NA	NA	PE1	4
+NX_Q8N3Y1	F-box/WD repeat-containing protein 8	598	67394	5.42	0	Golgi apparatus;Cytosol;Perinuclear region	NA	Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).	NA	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	12
+NX_Q8N3Y3	LARGE xylosyl- and glucuronyltransferase 2	721	81787	7.69	1	Golgi apparatus membrane	NA	Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Has a higher activity toward alpha-dystroglycan than LARGE.	NA	In the N-terminal section; belongs to the glycosyltransferase 8 family.;In the C-terminal section; belongs to the glycosyltransferase 49 family.	Protein modification; protein glycosylation.;O-linked glycosylation	PE1	11
+NX_Q8N3Y7	Epidermal retinol dehydrogenase 2	309	34095	8.72	2	Endoplasmic reticulum membrane	NA	Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Cofactor metabolism; retinol metabolism.;RA biosynthesis pathway	PE1	8
+NX_Q8N3Z0	Inactive serine protease 35	413	47098	9.72	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family.	NA	PE1	6
+NX_Q8N3Z3	GTP-binding protein 8	284	32147	9.47	0	Mitochondrion	NA	NA	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.	NA	PE1	3
+NX_Q8N3Z6	Zinc finger CCHC domain-containing protein 7	543	63052	7.03	0	Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	9
+NX_Q8N402	Putative uncharacterized protein LOC388882	240	26933	4.58	0	NA	NA	NA	NA	NA	NA	PE2	22
+NX_Q8N412	Sperm-tail PG-rich repeat-containing protein 2	459	50660	9.6	0	NA	NA	NA	NA	NA	NA	PE2	4
+NX_Q8N413	Solute carrier family 25 member 45	288	31906	9.32	6	Nucleoplasm;Cytosol;Mitochondrion inner membrane	NA	NA	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	11
+NX_Q8N414	PiggyBac transposable element-derived protein 5	524	58464	9.03	0	Nucleoplasm;Nucleus	NA	Transposase that mediates sequence-specific genomic rearrangements (PubMed:26406119, PubMed:28504702). Can induce genomic rearrangements that inactivate the HPRT1 gene (PubMed:27491780).	NA	NA	NA	PE1	1
+NX_Q8N423	Leukocyte immunoglobulin-like receptor subfamily B member 2	598	65039	6.79	1	Cell membrane	NA	Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885).	Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.	NA	Osteoclast differentiation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Neutrophil degranulation	PE1	19
+NX_Q8N427	Thioredoxin domain-containing protein 3	588	67270	4.9	0	Cytoplasm	Ciliary dyskinesia, primary, 6	Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.	NA	In the C-terminal section; belongs to the NDK family.	NA	PE1	7
+NX_Q8N428	Polypeptide N-acetylgalactosaminyltransferase 16	558	63074	9.28	1	Nucleoplasm;Golgi apparatus membrane	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	14
+NX_Q8N431	Ras-GEF domain-containing family member 1C	466	52870	7.58	0	Mitochondrion	NA	Guanine nucleotide exchange factor (GEF).	NA	NA	NA	PE2	5
+NX_Q8N434	Putative transporter SVOPL	492	53991	9.07	10	Membrane	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE2	7
+NX_Q8N436	Inactive carboxypeptidase-like protein X2	756	85870	6.4	0	Secreted	NA	May be involved in cell-cell interactions.	NA	Belongs to the peptidase M14 family.	NA	PE1	10
+NX_Q8N441	Fibroblast growth factor receptor-like 1	504	54537	9.79	1	Membrane;Cytoplasmic vesicle	NA	Has a negative effect on cell proliferation.	NA	NA	FGFRL1 modulation of FGFR1 signaling	PE1	4
+NX_Q8N442	Translation factor GUF1, mitochondrial	669	74328	8.75	0	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	Epileptic encephalopathy, early infantile, 40	Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.	NA	PE1	4
+NX_Q8N443	RIB43A-like with coiled-coils protein 1	379	44015	8.92	0	Nucleus	NA	NA	NA	Belongs to the RIB43A family.	NA	PE1	X
+NX_Q8N446	Zinc finger protein 843	348	37065	9.85	0	NA	NA	NA	NA	NA	NA	PE1	16
+NX_Q8N448	Ligand of Numb protein X 2	690	76004	6.17	0	Cytoplasmic vesicle;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	13
+NX_Q8N456	Leucine-rich repeat-containing protein 18	261	29737	9.83	0	Cytoplasm	NA	May be involved in the regulation of spermatogenesis and sperm maturation.	NA	NA	NA	PE1	10
+NX_Q8N461	F-box/LRR-repeat protein 16	479	51658	6.09	0	NA	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	16
+NX_Q8N465	D-2-hydroxyglutarate dehydrogenase, mitochondrial	521	56416	8.21	0	Mitochondrion	D-2-hydroxyglutaric aciduria 1	Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate.	NA	Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	PE1	2
+NX_Q8N468	Major facilitator superfamily domain-containing protein 4A	514	56265	8.67	12	Membrane;Endosome	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE1	1
+NX_Q8N474	Secreted frizzled-related protein 1	314	35386	9.1	0	Cytosol;Secreted;Nucleolus	NA	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.	NA	Belongs to the secreted frizzled-related protein (sFRP) family.	Wnt signaling pathway;TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists	PE1	8
+NX_Q8N475	Follistatin-related protein 5	847	95751	5.61	0	Secreted	NA	NA	NA	NA	NA	PE1	4
+NX_Q8N485	Protein limb expression 1 homolog	282	31891	5.37	0	Cytoplasmic vesicle;Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the LIX1 family.	NA	PE2	5
+NX_Q8N488	RING1 and YY1-binding protein	228	24822	9.66	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911).	Monoubiquitinated.	NA	Transcriptional Regulation by E2F6;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	3
+NX_Q8N490	Probable hydrolase PNKD	385	42876	9.22	0	Membrane;Cytoplasm;Mitochondrion;Nucleus	Dystonia 8	Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway.	NA	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.	NA	PE1	2
+NX_Q8N4A0	Polypeptide N-acetylgalactosaminyltransferase 4	578	66666	7.55	1	Golgi apparatus;Golgi apparatus membrane	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	12
+NX_Q8N4B1	Sesquipedalian-1	249	27215	9.18	0	trans-Golgi network;Recycling endosome;Early endosome;Clathrin-coated vesicle	NA	Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.	NA	Belongs to the sesquipedalian family.	NA	PE1	12
+NX_Q8N4B4	F-box only protein 39	442	52646	9.1	0	NA	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	NA	PE2	17
+NX_Q8N4B5	Proline-rich protein 18	295	30926	11.09	0	NA	NA	NA	NA	NA	NA	PE1	6
+NX_Q8N4C0	Putative uncharacterized protein C9orf62	152	16682	10.45	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q8N4C6	Ninein	2090	243249	4.99	0	Cytoplasm;Centriole;Nucleolus;Nucleoplasm;Centrosome	Seckel syndrome 7	Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061).	Phosphorylated by AURKA/Aurora kinase A and PKA kinases but not CK2 or AURKB/ Aurora kinase B.;NIN is phosphorylated by AURKA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	14
+NX_Q8N4C7	Syntaxin-19	294	34324	7.05	0	Cytoplasm;Cytosol;Cytoskeleton;Cell membrane	NA	Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR).	NA	Belongs to the syntaxin family.	SNARE interactions in vesicular transport	PE1	3
+NX_Q8N4C8	Misshapen-like kinase 1	1332	149822	7.85	0	Golgi apparatus;Cytoplasm;Postsynaptic density;Axon;Dendrite	NA	Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.;Can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.	Autophosphorylated.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	Oxidative Stress Induced Senescence	PE1	17
+NX_Q8N4C9	Uncharacterized protein C17orf78	275	30555	9.62	1	Membrane	NA	NA	NA	NA	NA	PE2	17
+NX_Q8N4E4	Phosducin-like protein 2	241	28071	4.79	0	NA	NA	May play a role in germ cell maturation.	NA	Belongs to the phosducin family.	NA	PE1	4
+NX_Q8N4E7	Ferritin, mitochondrial	242	27538	6.79	0	Mitochondrion	NA	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	NA	Belongs to the ferritin family.	Porphyrin and chlorophyll metabolism;Mineral absorption;Iron uptake and transport	PE1	5
+NX_Q8N4F0	BPI fold-containing family B member 2	458	49172	8.82	0	Cytoplasmic vesicle;Secreted	NA	NA	NA	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Antimicrobial peptides;Post-translational protein phosphorylation	PE1	20
+NX_Q8N4F4	Solute carrier family 22 member 24	322	35933	5.39	6	Membrane	NA	NA	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	NA	PE2	11
+NX_Q8N4F7	RING finger protein 175	328	38266	9.07	5	Membrane	NA	NA	NA	NA	NA	PE1	4
+NX_Q8N4G2	ADP-ribosylation factor-like protein 14	192	21588	8.93	0	Cytoplasmic vesicle	NA	GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	3
+NX_Q8N4H0	Spermatogenesis associated 6-like protein	392	45058	9.22	0	NA	NA	NA	NA	Belongs to the SPATA6 family.	NA	PE1	9
+NX_Q8N4H5	Mitochondrial import receptor subunit TOM5 homolog	51	6035	9.69	1	Mitochondrion outer membrane;Mitochondrion	NA	NA	NA	Belongs to the Tom5 family.	Mitochondrial protein import;Pink/Parkin Mediated Mitophagy	PE1	9
+NX_Q8N4J0	Carnosine N-methyltransferase	409	47186	5.93	0	Cytosol;Nucleus	NA	N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).	NA	Belongs to the carnosine N-methyltransferase family.	Histidine catabolism	PE1	9
+NX_Q8N4K4	Reprimo-like protein	120	12312	5.51	1	Membrane	NA	NA	NA	Belongs to the reprimo family.	NA	PE2	17
+NX_Q8N4L1	Transmembrane protein 151A	468	51278	8.31	2	Membrane;Cytosol;Nucleolus	NA	NA	NA	Belongs to the TMEM151 family.	NA	PE1	11
+NX_Q8N4L2	Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	257	28081	9.07	2	Phagosome membrane;Lysosome membrane;Late endosome membrane;Cell membrane	NA	Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity).	NA	NA	NA	PE1	8
+NX_Q8N4L4	Spermatid maturation protein 1	309	34773	8.07	1	Membrane;Cytoplasm	NA	Required for proper cytoplasm removal during spermatogenesis.	NA	NA	NA	PE1	17
+NX_Q8N4L8	Coiled-coil domain-containing protein 24	307	34322	6.57	0	Cytosol;Nucleolus;Cell membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q8N4M1	Choline transporter-like protein 3	653	73783	7.92	8	Membrane	NA	NA	NA	Belongs to the CTL (choline transporter-like) family.	Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds	PE1	1
+NX_Q8N4M7	Putative uncharacterized protein C10orf126	172	19474	5.3	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_Q8N4N3	Kelch-like protein 36	616	69896	5.85	0	Cytosol	NA	Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	NA	Protein modification; protein ubiquitination.	PE1	16
+NX_Q8N4N8	Kinesin-like protein KIF2B	673	76254	8.89	0	Nucleolus;Centrosome;Spindle;Kinetochore;Cytoskeleton	NA	Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108).	Phosphorylation at Thr-125 by PLK1 is required for activity in the correction of kinetochore-microtubules attachment errors, while phosphorylation at Ser-204 also by PLK1 is required for the kinetochore localization and activity in prometaphase.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.	Separation of Sister Chromatids;MHC class II antigen presentation;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-dependent Golgi-to-ER retrograde traffic	PE1	17
+NX_Q8N4P2	Tetratricopeptide repeat protein 30B	665	76099	5.12	0	Cilium	NA	Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.	NA	Belongs to the TTC30/dfy-1/fleer family.	Intraflagellar transport	PE1	2
+NX_Q8N4P3	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1	179	20329	6.25	0	Nucleoplasm;Cytosol	NA	PpGpp hydrolyzing enzyme involved in starvation response.	NA	Belongs to the MESH1 family.	NA	PE1	15
+NX_Q8N4P6	Leucine-rich repeat-containing protein 71	559	61825	9.3	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q8N4Q0	Prostaglandin reductase 3	377	40140	8.38	0	Golgi apparatus;Nucleoplasm;Peroxisome;Cytoplasmic vesicle	NA	Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.	NA	PE1	18
+NX_Q8N4Q1	Mitochondrial intermembrane space import and assembly protein 40	142	15996	4.23	0	Mitochondrion intermembrane space;Mitochondrion	NA	Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364, PubMed:23676665, PubMed:30885959). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS (PubMed:30885959). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23676665). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864).	Forms intrachain disulfide bridges, but exists in different redox states.	NA	Mitochondrial protein import	PE1	3
+NX_Q8N4S0	Coiled-coil domain-containing protein 82	544	64002	4.91	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	11
+NX_Q8N4S7	Progestin and adipoQ receptor family member 4	273	29126	9.26	6	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the ADIPOR family.	NA	PE1	16
+NX_Q8N4S9	MARVEL domain-containing protein 2	558	64168	7.21	6	Tight junction;Cell junction;Cell membrane	Deafness, autosomal recessive, 49	Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462).	Phosphorylated.;Ubiquitinated by ITCH; but this ubiquitination does not lead to proteasomal degradation.	NA	NA	PE1	5
+NX_Q8N4T0	Carboxypeptidase A6	437	51008	9.58	0	Extracellular matrix	Epilepsy, familial temporal lobe, 5;Febrile seizures, familial, 11	May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II (PubMed:18178555). Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine (PubMed:20855895).	NA	Belongs to the peptidase M14 family.	NA	PE1	8
+NX_Q8N4T4	Rho guanine nucleotide exchange factor 39	335	38295	9.71	0	Cell membrane	NA	Promotes cell proliferation.	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	9
+NX_Q8N4T8	Carbonyl reductase family member 4	237	25301	9.4	0	Mitochondrion matrix	NA	The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (PubMed:19000905). Both homotetramer and the heterotetramer have broad substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Lipid metabolism; fatty acid biosynthesis.;Fatty acyl-CoA biosynthesis	PE1	4
+NX_Q8N4U5	T-complex protein 11-like protein 2	519	58091	4.89	0	Nucleus speckle	NA	NA	NA	Belongs to the TCP11 family.	NA	PE1	12
+NX_Q8N4V1	Membrane magnesium transporter 1	131	14686	9.2	2	Early endosome membrane;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Mediates Mg(2+) transport.	NA	Belongs to the membrane magnesium transporter (TC 1.A.67) family.	Miscellaneous transport and binding events	PE1	X
+NX_Q8N4V2	Synaptic vesicle 2-related protein	548	60769	5.6	12	Synaptic vesicle membrane	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE1	12
+NX_Q8N4W6	DnaJ homolog subfamily C member 22	341	38086	9.39	7	Membrane;Cytoplasmic vesicle	NA	May function as a co-chaperone.	NA	NA	NA	PE1	12
+NX_Q8N4W9	Zinc finger protein 808	903	104825	9.59	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8N4X5	Actin filament-associated protein 1-like 2	818	91300	5.22	0	Cytoplasm;Cytosol;Cell membrane	NA	May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.	Tyrosine phosphorylated (by SRC).	NA	NA	PE1	10
+NX_Q8N4Y2	EF-hand calcium-binding domain-containing protein 4A	399	44956	5.28	0	Nucleus	NA	Plays a role in store-operated Ca(2+) entry (SOCE).	NA	Belongs to the EFCAB4 family.	NA	PE1	11
+NX_Q8N4Z0	Ras-related protein Rab-42	218	24133	6.59	0	Membrane;Endoplasmic reticulum	NA	NA	NA	Belongs to the small GTPase superfamily. Rab family.	RAB geranylgeranylation	PE1	1
+NX_Q8N511	Transmembrane protein 199	208	23130	9.09	2	COPI-coated vesicle membrane;Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane	Congenital disorder of glycosylation 2P	Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833330).	NA	NA	NA	PE1	17
+NX_Q8N531	F-box/LRR-repeat protein 6	539	58588	9.51	0	Nucleoplasm;Cytoplasmic vesicle	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	NA	PE1	8
+NX_Q8N535	Putative uncharacterized protein encoded by LINC00471	108	12106	5.44	0	NA	NA	NA	NA	NA	NA	PE5	2
+NX_Q8N539	Fibrinogen C domain-containing protein 1	461	50744	6.02	1	Membrane;Cell junction	NA	Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.	NA	NA	NA	PE1	9
+NX_Q8N543	Prolyl 3-hydroxylase OGFOD1	542	63246	5.03	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.	NA	Belongs to the TPA1 family.	NA	PE1	16
+NX_Q8N554	Zinc finger protein 276	614	67219	8.87	0	Cell membrane;Nucleolus;Nucleoplasm;Cytosol;Nucleus;Kinetochore	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	16
+NX_Q8N556	Actin filament-associated protein 1	730	80725	8.87	0	Stress fiber;Cytosol;Focal adhesion;Cytoskeleton	NA	Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.	Phosphorylated on tyrosine residues by SRC.	NA	NA	PE1	4
+NX_Q8N565	Melanoregulin	214	24927	5.53	0	Lysosome membrane;Cytoplasmic vesicle membrane;Cytoplasmic vesicle;Apical cell membrane;Melanosome membrane	NA	Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity).	Palmitoylated. Palmitoylation is required to maintain the protein at the melanosome membrane.	Belongs to the melanoregulin family.	NA	PE1	2
+NX_Q8N567	Zinc finger CCHC domain-containing protein 9	271	30477	9.33	0	Nucleoplasm;Nucleus;Nucleolus	NA	May down-regulate transcription mediated by NF-kappa-B and the serum response element.	NA	NA	NA	PE1	5
+NX_Q8N568	Serine/threonine-protein kinase DCLK2	766	83606	8.63	0	Cytoskeleton	NA	Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).	Autophosphorylated.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	NA	PE1	4
+NX_Q8N573	Oxidation resistance protein 1	874	97970	5.32	0	Cytoplasmic vesicle;Mitochondrion	NA	May be involved in protection from oxidative damage.	NA	Belongs to the OXR1 family.	NA	PE1	8
+NX_Q8N584	Tetratricopeptide repeat protein 39C	583	65870	6.59	0	Nucleoplasm	NA	NA	NA	Belongs to the TTC39 family.	NA	PE1	18
+NX_Q8N587	Zinc finger protein 561	486	55197	9.09	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8N594	MPN domain-containing protein	471	50662	5.49	0	Nucleoplasm;Nucleolus	NA	Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (PubMed:30982744).	Degraded following binding to N(6)-methyladenosine methylated DNA (m6A).	Belongs to the peptidase M67 family.	NA	PE1	19
+NX_Q8N5A5	Zinc finger CCCH-type with G patch domain-containing protein	531	57359	5.3	0	Nucleoplasm;Nucleus;Cell membrane	NA	Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.;Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.	Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP.	NA	NA	PE1	20
+NX_Q8N5B7	Ceramide synthase 5	392	45752	8.21	6	Nucleoplasm;Endoplasmic reticulum membrane;Nucleolus	NA	Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068). Can use other acyl donors, but with less efficiency (By similarity).	Phosphorylated at the C-terminus by CK2.	NA	Lipid metabolism; sphingolipid metabolism.;Sphingolipid de novo biosynthesis	PE1	12
+NX_Q8N5C1	Calcium homeostasis modulator protein 5	309	35170	8.49	4	Membrane;Golgi apparatus	NA	Pore-forming subunit of a voltage-gated ion channel.	NA	Belongs to the CALHM family.	NA	PE1	6
+NX_Q8N5C6	S1 RNA-binding domain-containing protein 1	995	111776	8.94	0	Cytosol;Mitochondrion	NA	NA	NA	NA	NA	PE1	2
+NX_Q8N5C7	DTW domain-containing protein 1	304	35248	8.65	0	Nucleoplasm;Nucleolus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the DTW family.	NA	PE1	15
+NX_Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	712	78653	8.81	0	Cytosol;Nucleus speckle	NA	Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor.;May be an oncogenic factor.	Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.;Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment.	NA	NOD-like receptor signaling pathway;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;IRAK2 mediated activation of TAK1 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;TNFR1-induced NFkappaB signaling pathway;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling	PE1	X
+NX_Q8N5D0	WD and tetratricopeptide repeats protein 1	677	75920	6.85	0	Golgi apparatus;Cytoplasmic vesicle	NA	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	NA	NA	Protein modification; protein ubiquitination.;Neddylation	PE1	1
+NX_Q8N5D6	Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1	347	40127	8.68	1	Golgi apparatus membrane	NA	Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens.	NA	Belongs to the glycosyltransferase 6 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - globo series;Metabolic pathways	PE1	9
+NX_Q8N5F7	NF-kappa-B-activating protein	415	47138	10.12	0	Nucleoplasm;Cytosol;Nucleus	NA	Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.	NA	Belongs to the NKAP family.	NA	PE1	X
+NX_Q8N5G0	Small integral membrane protein 20	67	7702	9.86	1	Nucleoplasm;Cytosol;Mitochondrion inner membrane;Nucleolus	NA	Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C. Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover.	NA	NA	NA	PE1	4
+NX_Q8N5G2	Macoilin	664	76178	9.17	4	Cytosol;Axon;Rough endoplasmic reticulum membrane;Nucleus membrane	NA	Plays a role in the regulation of neuronal activity.	NA	Belongs to the macoilin family.	NA	PE1	1
+NX_Q8N5H3	Leucine repeat adapter protein 25	189	20147	5.1	0	Cytoplasm;Lamellipodium	NA	Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.	NA	Belongs to the FAM89 family.	NA	PE1	11
+NX_Q8N5H7	SH2 domain-containing protein 3C	860	94411	8.2	0	Membrane;Cytoplasm	NA	Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity).	NA	NA	NA	PE1	9
+NX_Q8N5I2	Arrestin domain-containing protein 1	433	45981	6.53	0	Cell membrane	NA	Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940).	Ubiquitinated (PubMed:21191027, PubMed:22315426). Ubiquitination by WWP2; promotes localization to extracellular microvesicles (PubMed:22315426). Ubiquitinated by WWP1 (PubMed:21191027).	Belongs to the arrestin family.	NA	PE1	9
+NX_Q8N5I3	Potassium channel regulatory protein	272	31048	6.91	0	Endoplasmic reticulum;Cytoplasmic vesicle	NA	Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.	NA	NA	NA	PE1	13
+NX_Q8N5I4	Dehydrogenase/reductase SDR family member on chromosome X	330	36443	9.1	0	Cytosol;Secreted;Cytoskeleton	NA	Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	NA	PE1	X
+NX_Q8N5I9	Uncharacterized protein C12orf45	185	20123	5.1	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	NA	NA	NA	NA	PE1	12
+NX_Q8N5J2	Ubiquitin carboxyl-terminal hydrolase MINDY-1	469	51778	4.75	0	Nucleoplasm	NA	Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.	NA	Belongs to the MINDY deubiquitinase family. FAM63 subfamily.	NA	PE1	1
+NX_Q8N5J4	Transcription factor Spi-C	248	29180	9.02	0	Nucleus	NA	Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).	NA	Belongs to the ETS family.	NA	PE2	12
+NX_Q8N5K1	CDGSH iron-sulfur domain-containing protein 2	135	15278	9.66	1	Mitochondrion outer membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane	Wolfram syndrome 2	Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.	NA	Belongs to the CISD protein family. CISD2 subfamily.	NA	PE1	4
+NX_Q8N5L8	Ribonuclease P protein subunit p25-like protein	163	17631	10.32	0	Nucleoplasm;Nucleus	NA	May be a component of ribonuclease P or MRP.	NA	Belongs to the histone-like Alba family.	Ribosome biogenesis in eukaryotes;RNA transport	PE1	9
+NX_Q8N5M1	ATP synthase mitochondrial F1 complex assembly factor 2	289	32772	6.62	0	Cytosol;Mitochondrion	Mitochondrial complex V deficiency, nuclear type 1	May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase).	NA	Belongs to the ATP12 family.	NA	PE1	17
+NX_Q8N5M4	Tetratricopeptide repeat protein 9C	171	20013	9.02	0	Cytoplasm;Nucleoplasm	NA	NA	NA	Belongs to the TTC9 family.	NA	PE1	11
+NX_Q8N5M9	Protein jagunal homolog 1	183	21125	9.72	4	Cytoplasm;Endoplasmic reticulum membrane;Endoplasmic reticulum;Cytoplasmic vesicle;Nucleus	Neutropenia, severe congenital 6, autosomal recessive	Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.	NA	Belongs to the jagunal family.	NA	PE1	3
+NX_Q8N5N4	Uncharacterized protein C3orf22	141	15686	9.89	0	NA	NA	NA	NA	NA	NA	PE2	3
+NX_Q8N5N7	39S ribosomal protein L50, mitochondrial	158	18325	7.73	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL50 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	9
+NX_Q8N5P1	Zinc finger CCCH domain-containing protein 8	291	33576	8.55	0	Nucleoplasm;Nucleus	NA	Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.	NA	NA	RNA polymerase II transcribes snRNA genes	PE1	2
+NX_Q8N5Q1	Protein FAM71E2	922	99915	9.45	0	NA	NA	NA	NA	Belongs to the FAM71 family.	NA	PE1	19
+NX_Q8N5R6	Coiled-coil domain-containing protein 33	958	107216	6.32	0	NA	NA	NA	NA	NA	NA	PE1	15
+NX_Q8N5S1	Solute carrier family 25 member 41	370	40795	9.35	6	Mitochondrion inner membrane	NA	NA	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	19
+NX_Q8N5S3	Uncharacterized protein C2orf73	287	32142	9.07	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q8N5S9	Calcium/calmodulin-dependent protein kinase kinase 1	505	55735	5.55	0	Cytoplasm;Cytosol;Nucleus	NA	Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.	Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).;CAMKK1 is phosphorylated by CAMK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);Autophosphorylated (Phosphothreonine:PTM-0254)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	Adipocytokine signaling pathway;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CaMK IV-mediated phosphorylation of CREB;Activation of RAC1 downstream of NMDARs	PE1	17
+NX_Q8N5T2	TBC1 domain family member 19	526	60208	5.67	0	Nucleoplasm;Nucleus membrane	NA	May act as a GTPase-activating protein for Rab family protein(s).	NA	NA	NA	PE1	4
+NX_Q8N5U0	Uncharacterized protein C11orf42	333	36368	8.57	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_Q8N5U1	Membrane-spanning 4-domains subfamily A member 15	240	25050	5.63	4	Membrane;Cytosol;Cell membrane	NA	May be involved in signal transduction as a component of a multimeric receptor complex.	NA	Belongs to the MS4A family.	NA	PE2	11
+NX_Q8N5U6	RING finger protein 10	811	89927	6.48	0	Cytoplasm;Nucleoplasm;Mitochondrion;Nucleus	NA	Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.	NA	Belongs to the RNF10 family.	NA	PE1	12
+NX_Q8N5V2	Ephexin-1	710	82496	5.42	0	Cytoplasm;Cell membrane;Growth cone;Membrane;Cytosol	NA	Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).	Src-dependent phosphorylation at Tyr-179 upon EPHA4 activation increases the guanine exchange factor activity toward RHOA. Phosphorylation by CDK5 upon EPHA4 activation by EFNA1 may regulate dendritic spine morphogenesis (By similarity).	NA	Axon guidance;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;EPHA-mediated growth cone collapse	PE1	2
+NX_Q8N5W8	Protein FAM24B	94	10147	6.68	0	Secreted	NA	NA	NA	Belongs to the FAM24 family.	NA	PE1	10
+NX_Q8N5W9	Refilin-B	214	22882	5.27	0	Cytosol;Cell membrane;Cytoskeleton	NA	Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.	NA	Belongs to the Refilin family.	NA	PE1	17
+NX_Q8N5X7	Eukaryotic translation initiation factor 4E type 3	224	24441	5.98	0	Nucleolus	NA	Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity).	NA	Belongs to the eukaryotic initiation factor 4E family.	ISG15 antiviral mechanism	PE1	3
+NX_Q8N5Y2	Male-specific lethal 3 homolog	521	59824	8.4	0	Nucleus	NA	Has a role in chromatin remodeling and transcriptional regulation (PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699). Has a role in X inactivation (PubMed:21217699). Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure (PubMed:16227571, PubMed:20657587, PubMed:16543150). Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666).	NA	NA	HATs acetylate histones	PE1	X
+NX_Q8N5Y8	Protein mono-ADP-ribosyltransferase PARP16	322	36383	9.17	1	Endoplasmic reticulum membrane	NA	Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).	Auto-mono-ADP-ribosylated.	NA	Nicotinamide salvaging	PE1	15
+NX_Q8N5Z0	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	425	47352	6.47	0	Cytoplasmic vesicle;Mitochondrion;Cell membrane	NA	Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).	NA	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6.;Lysine biosynthesis;Lysine degradation;Tryptophan metabolism;Metabolic pathways;Tryptophan catabolism;Lysine catabolism	PE1	4
+NX_Q8N5Z5	BTB/POZ domain-containing protein KCTD17	321	35670	4.82	0	Cytoplasm	Dystonia 26, myoclonic	Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243).	NA	NA	NA	PE1	22
+NX_Q8N608	Inactive dipeptidyl peptidase 10	796	90888	6.11	1	Cell membrane	Asthma	Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).	N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.	Belongs to the peptidase S9B family. DPPIV subfamily.	NA	PE1	2
+NX_Q8N609	Translocating chain-associated membrane protein 1-like 1	369	42162	9.38	8	Endoplasmic reticulum membrane;Endoplasmic reticulum;Mitochondrion	NA	Stimulatory or required for the translocation of secretory proteins across the ER membrane.	NA	Belongs to the TRAM family.	NA	PE1	4
+NX_Q8N612	FTS and Hook-interacting protein	972	105568	6.33	0	Cytoplasm;Mitochondrion;Nucleus	NA	Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).	NA	Belongs to the UPF0518 family.	NA	PE1	11
+NX_Q8N614	Transmembrane protein 156	296	34323	7.98	2	Membrane	NA	NA	NA	NA	NA	PE1	4
+NX_Q8N616	Putative uncharacterized protein encoded by LINC00311	119	12924	6.53	0	NA	NA	NA	NA	NA	NA	PE5	16
+NX_Q8N628	Olfactory receptor 2C3	320	35376	7.13	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8N635	Meiosis-specific with OB domain-containing protein	442	49313	5.98	0	Cytoplasm;Nucleus;Chromosome	Spermatogenic failure 22	Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity).	NA	Belongs to the MEIOB family.	NA	PE1	16
+NX_Q8N653	Leucine-zipper-like transcriptional regulator 1	840	94719	6.12	0	Golgi apparatus;Recycling endosome;Endomembrane system;Nucleoplasm;Centrosome;Cytosol	Noonan syndrome 2;Glioma;Noonan syndrome 10;Schwannomatosis 2	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304).	Phosphorylated on tyrosine upon induction of apoptosis, leading to its degradation by the proteasome.	Belongs to the LZTR1 family.	Protein modification; protein ubiquitination.	PE1	22
+NX_Q8N660	Neuroblastoma breakpoint family member 15	670	77563	4.63	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE2	1
+NX_Q8N661	Lysoplasmalogenase	226	24352	6.15	7	Membrane;Cytoplasm;Centrosome;Midbody	NA	Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.	NA	Belongs to the TMEM86 family.	Acyl chain remodelling of PC	PE1	19
+NX_Q8N668	COMM domain-containing protein 1	190	21178	5.85	0	Cytoplasm;Endosome membrane;Recycling endosome;Early endosome;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141). Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner (PubMed:28604741).	Acetylated by EP300 ina stimuli-specific manner; protecting it from XIAP-mediated proteasomal degradation and required for interaction with RElA in response to stress.;Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation.	NA	Neddylation	PE1	2
+NX_Q8N680	Zinc finger and BTB domain-containing protein 2	514	57337	5.71	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	6
+NX_Q8N682	DNA damage-regulated autophagy modulator protein 1	238	26253	6.39	6	Lysosome membrane	NA	Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.	NA	Belongs to the DRAM/TMEM150 family.	NA	PE1	12
+NX_Q8N684	Cleavage and polyadenylation specificity factor subunit 7	471	52050	7.82	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:8626397, PubMed:17024186, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:8626397, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:8626397, PubMed:17024186).	Phosphorylated (PubMed:29276085).;Asymmetrically dimethylated on arginine residues by PRMT1 (PubMed:20562214).	Belongs to the RRM CPSF6/7 family.	mRNA surveillance pathway;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	11
+NX_Q8N687	Beta-defensin 125	156	17537	5.31	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	20
+NX_Q8N688	Beta-defensin 123	67	8105	9.77	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	20
+NX_Q8N690	Beta-defensin 119	84	9822	8.92	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	20
+NX_Q8N693	Homeobox protein ESX1	406	44297	5.19	0	Cytoplasm;Nucleus speckle;Nucleus	NA	May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.	Undergoes proteolytic cleavage; produces a 45 kDa N-terminal homeodomain-containing fragment (ESXR1-N) and a 20 kDa C-terminal fragment (ESXR1-C).	NA	NA	PE1	X
+NX_Q8N695	Sodium-coupled monocarboxylate transporter 1	610	66578	7.9	13	Apical cell membrane	NA	Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.	NA	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Organic anion transporters;Nicotinamide salvaging	PE1	12
+NX_Q8N697	Solute carrier family 15 member 4	577	62034	9.2	12	Membrane;Nucleoplasm	NA	Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.	NA	Belongs to the PTR2/POT transporter (TC 2.A.17) family.	Proton/oligopeptide cotransporters;Neutrophil degranulation	PE1	12
+NX_Q8N699	Myc target protein 1	235	26593	9.88	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).	NA	Belongs to the MYCT1 family.	NA	PE1	6
+NX_Q8N6C5	Immunoglobulin superfamily member 1	1336	148936	5.63	2	Membrane;Cytosol;Secreted	Hypothyroidism, central, and testicular enlargement	Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription.	NA	NA	NA	PE1	X
+NX_Q8N6C7	Putative uncharacterized protein encoded by MIR7-3HG	128	14321	10.38	0	NA	NA	NA	NA	NA	NA	PE5	19
+NX_Q8N6C8	Leukocyte immunoglobulin-like receptor subfamily A member 3	439	47472	8.37	0	Secreted	NA	Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.	N-glycosylation is required for ligand binding.	NA	Osteoclast differentiation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Neutrophil degranulation	PE1	19
+NX_Q8N6D2	E3 ubiquitin-protein ligase RNF182	247	27402	5.82	2	Golgi apparatus;Cytoplasm;Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway (PubMed:18298843). Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA (PubMed:31432514).	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	6
+NX_Q8N6D5	Ankyrin repeat domain-containing protein 29	301	32442	9.46	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	18
+NX_Q8N6F1	Claudin-19	224	23229	8.49	4	Tight junction;Cell membrane	Hypomagnesemia 5, renal, with or without ocular involvement	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	1
+NX_Q8N6F7	Germinal center-associated signaling and motility protein	178	21005	6.07	0	Cytoplasm;Cell membrane	NA	Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.	Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN.	NA	NA	PE1	3
+NX_Q8N6F8	Methyltransferase-like protein 27	245	26522	5.74	0	Focal adhesion	NA	NA	NA	NA	NA	PE1	7
+NX_Q8N6G1	Putative uncharacterized protein encoded by LINC00337	96	10504	9.35	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q8N6G2	Testis-expressed protein 26	289	33595	9.4	0	NA	NA	NA	NA	NA	NA	PE1	13
+NX_Q8N6G5	Chondroitin sulfate N-acetylgalactosaminyltransferase 2	542	62572	5.5	1	Golgi stack membrane;Endoplasmic reticulum	NA	Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains.	NA	Belongs to the chondroitin N-acetylgalactosaminyltransferase family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Metabolic pathways;Chondroitin sulfate biosynthesis	PE1	10
+NX_Q8N6G6	ADAMTS-like protein 1	1762	193409	8.18	0	Cytoplasmic vesicle;Extracellular matrix	NA	NA	Disulfide bonds are present.;C-, N- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTSL1. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	9
+NX_Q8N6H7	ADP-ribosylation factor GTPase-activating protein 2	521	56720	8.08	0	Golgi apparatus;Cytoplasm;Golgi apparatus membrane	NA	GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.	NA	NA	Endocytosis;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	11
+NX_Q8N6I1	EP300-interacting inhibitor of differentiation 2	236	25190	6.94	0	Nucleoplasm;Nucleus	NA	Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.	NA	NA	NA	PE1	19
+NX_Q8N6I4	Transmembrane protein 251	163	18747	8.38	2	Membrane;Golgi apparatus;Cell junction	NA	NA	NA	Belongs to the TMEM251 family.	NA	PE1	14
+NX_Q8N6K0	Testis-expressed protein 29	151	16649	4.99	1	Membrane	NA	NA	NA	NA	NA	PE1	13
+NX_Q8N6K4	Putative uncharacterized protein MGC34800	173	17423	9.65	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_Q8N6K7	Sterile alpha motif domain-containing protein 3	520	61237	6.67	0	NA	NA	NA	NA	NA	NA	PE1	6
+NX_Q8N6L0	Protein KASH5	562	62783	4.65	1	Nucleus outer membrane;Telomere;Nucleus	NA	As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.	NA	NA	NA	PE1	19
+NX_Q8N6L1	Keratinocyte-associated protein 2	136	14679	9.67	3	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:22467853). May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116).	NA	Belongs to the KRTCAP2 family.	Protein modification; protein glycosylation.	PE1	1
+NX_Q8N6L7	Transmembrane protein 252	170	18703	4.88	2	Membrane	NA	NA	NA	NA	NA	PE2	9
+NX_Q8N6M0	Deubiquitinase OTUD6B	293	33813	5.77	0	Golgi apparatus;Nucleoplasm;Cytosol	Intellectual developmental disorder with dysmorphic facies, seizures, and distal limb anomalies	Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability.;Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629).	NA	NA	NA	PE1	8
+NX_Q8N6M3	Fat storage-inducing transmembrane protein 2	262	29855	8.93	6	Endoplasmic reticulum membrane	NA	Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization.	NA	Belongs to the FIT family.	Lipid particle organization	PE1	20
+NX_Q8N6M5	Probable allantoicase	391	43559	5.79	0	NA	NA	The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.	NA	Belongs to the allantoicase family.	Purine metabolism;Metabolic pathways	PE2	2
+NX_Q8N6M6	Aminopeptidase O	819	93572	5.81	0	Cytoplasm;Cell junction;Nucleolus	NA	Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.	NA	Belongs to the peptidase M1 family.	Metabolism of Angiotensinogen to Angiotensins	PE1	9
+NX_Q8N6M8	IQ domain-containing protein F1	205	23699	9.68	0	Acrosome	NA	Involved in sperm capacitation and acrosome reaction.	NA	NA	NA	PE1	3
+NX_Q8N6M9	AN1-type zinc finger protein 2A	145	16477	8.7	0	Cytoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	7
+NX_Q8N6N2	Tetratricopeptide repeat protein 9B	239	25932	9.55	0	NA	NA	NA	NA	Belongs to the TTC9 family.	NA	PE1	19
+NX_Q8N6N3	UPF0690 protein C1orf52	182	20599	5.14	0	Nucleoplasm	NA	NA	NA	Belongs to the UPF0690 family.	NA	PE1	1
+NX_Q8N6N6	Protein NATD1	113	13032	8.84	0	NA	NA	NA	NA	Belongs to the NATD1 family.	NA	PE1	17
+NX_Q8N6N7	Acyl-CoA-binding domain-containing protein 7	88	9790	6.26	0	Cytoplasmic vesicle;Cytosol	NA	Binds medium- and long-chain acyl-CoA esters.	NA	Belongs to the ACBD7 family.	Mitochondrial Fatty Acid Beta-Oxidation	PE1	10
+NX_Q8N6P7	Interleukin-22 receptor subunit alpha-1	574	63077	5.81	1	Membrane	NA	Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.	NA	Belongs to the type II cytokine receptor family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling	PE1	1
+NX_Q8N6Q1	Transmembrane and coiled-coil domain-containing protein 5A	288	34174	5.83	1	Membrane	NA	NA	NA	Belongs to the TMCO5 family.	NA	PE1	15
+NX_Q8N6Q3	CD177 antigen	437	46363	5.87	0	Cell membrane;Secreted;Lamellipodium;Cytoplasmic granule membrane;Membrane raft	NA	In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369).	A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding).;N-glycosylated.	NA	Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall;Neutrophil degranulation	PE1	19
+NX_Q8N6Q8	Methyltransferase-like protein 25	603	68213	6.69	0	Cytosol;Mitochondrion;Cell membrane	NA	Putative methyltransferase.	NA	NA	NA	PE1	12
+NX_Q8N6R0	eEF1A lysine and N-terminal methyltransferase	699	78768	6.29	0	Cytosol	NA	Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation (PubMed:30612740, PubMed:30143613). Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' (PubMed:30143613). Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' (PubMed:30612740, PubMed:30143613). Has no activity towards core histones H2A, H2B, H3 and H4 (PubMed:30612740).	NA	Belongs to the methyltransferase superfamily.	NA	PE1	1
+NX_Q8N6R1	Stress-associated endoplasmic reticulum protein 2	65	7431	10.61	1	Membrane;Endoplasmic reticulum membrane	NA	May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).	NA	Belongs to the RAMP4 family.	NA	PE1	13
+NX_Q8N6S4	Ankyrin repeat domain-containing protein 13C	541	60818	6.46	0	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.	NA	NA	NA	PE1	1
+NX_Q8N6S5	ADP-ribosylation factor-like protein 6-interacting protein 6	226	24676	5.94	3	Nucleus inner membrane;Cytosol;Nucleus membrane	NA	NA	NA	Belongs to the ARL6IP6 family.	NA	PE1	2
+NX_Q8N6T0	Type 2 DNA topoisomerase 6 subunit B-like	577	64047	6.2	0	Centrosome;Chromosome	NA	Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.	NA	Belongs to the TOP6B-like family.	NA	PE1	11
+NX_Q8N6T3	ADP-ribosylation factor GTPase-activating protein 1	406	44668	5.46	0	Golgi apparatus;Cytoplasm;Nucleus membrane;Cytoplasmic vesicle	NA	GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).	ARFGAP1 is phosphorylated by LRRK2	NA	Endocytosis;XBP1(S) activates chaperone genes;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Clathrin-mediated endocytosis	PE1	20
+NX_Q8N6T7	NAD-dependent protein deacetylase sirtuin-6	355	39119	9.31	0	Nucleoplasm	NA	NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.	NA	Belongs to the sirtuin family. Class IV subfamily.	Pre-NOTCH Transcription and Translation;Processing of DNA double-strand break ends	PE1	19
+NX_Q8N6U2	Putative uncharacterized protein encoded by LINC00612	182	18370	11.05	0	NA	NA	NA	NA	NA	NA	PE5	12
+NX_Q8N6U8	G-protein coupled receptor 161	529	58559	8.56	7	Cilium membrane;Nucleoplasm;Nucleolus;Cell membrane	NA	Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	Hedgehog 'on' state;Hedgehog 'off' state	PE1	1
+NX_Q8N6V4	UPF0728 protein C10orf53	93	10399	5.02	0	NA	NA	NA	NA	Belongs to the UPF0728 family.	NA	PE1	10
+NX_Q8N6V9	Testis-expressed protein 9	391	44826	6.21	0	Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	15
+NX_Q8N6W0	CUGBP Elav-like family member 5	485	52355	8.57	0	Cytoplasm;Nucleus	NA	RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.	NA	Belongs to the CELF/BRUNOL family.	NA	PE1	19
+NX_Q8N6Y0	Usher syndrome type-1C protein-binding protein 1	703	76068	5.58	0	NA	NA	NA	NA	Belongs to the MCC family.	NA	PE1	19
+NX_Q8N6Y1	Protocadherin-20	951	104919	4.91	1	Cytoplasmic vesicle;Cell membrane;Cytoskeleton	NA	Potential calcium-dependent cell-adhesion protein.	NA	NA	NA	PE1	13
+NX_Q8N6Y2	Leucine-rich repeat-containing protein 17	441	51800	8.5	0	Cytoplasmic vesicle;Extracellular space;Cytoskeleton	NA	Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).	NA	NA	NA	PE1	7
+NX_Q8N715	Coiled-coil domain-containing protein 185	623	72349	10.13	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q8N720	Zinc finger protein 655	491	57407	6.7	0	Nucleoplasm;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q8N726	Tumor suppressor ARF	132	13903	12.41	0	Nucleoplasm;Mitochondrion;Nucleolus	NA	Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.;May be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.	Ubiquitinated in normal cells by TRIP12 via the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination at the N-terminus, regardless of the absence of lysine residues. Ubiquitination leads to its proteasomal degradation. In cancer cells, however, TRIP12 is located in a different cell compartment, preventing ubiquitination and degradation.	NA	Cell cycle;p53 signaling pathway;HTLV-I infection;Pathways in cancer;Pancreatic cancer;Glioma;Melanoma;Bladder cancer;Chronic myeloid leukemia;Non-small cell lung cancer;SUMOylation of DNA damage response and repair proteins;Oxidative Stress Induced Senescence;Oncogene Induced Senescence;Stabilization of p53;Regulation of TP53 Degradation;SUMOylation of transcription factors;Regulation of RUNX3 expression and activity	PE1	9
+NX_Q8N729	Neuropeptide W	165	18048	11.62	0	Secreted	NA	Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.	NA	Belongs to the neuropeptide B/W family.	G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	16
+NX_Q8N743	Killer cell immunoglobulin-like receptor 3DL3	410	44928	7.27	1	Cell membrane	NA	Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.	NA	Belongs to the immunoglobulin superfamily.	Antigen processing and presentation	PE1	19
+NX_Q8N752	Casein kinase I isoform alpha-like	337	39086	9.48	0	Cytoplasm	NA	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).	NA	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.	Wnt signaling pathway;Hedgehog signaling pathway	PE1	13
+NX_Q8N755	Solute carrier family 66 member 3	202	22575	9.14	4	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	2
+NX_Q8N766	ER membrane protein complex subunit 1	993	111759	7.38	1	Membrane	Cerebellar atrophy, visual impairment, and psychomotor retardation	NA	NA	Belongs to the EMC1 family.	NA	PE1	1
+NX_Q8N769	Uncharacterized protein C14orf178	122	13377	5.55	0	NA	NA	NA	NA	NA	NA	PE2	14
+NX_Q8N782	Zinc finger protein 525	197	23070	8.98	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8N7A1	Kelch domain-containing protein 1	406	46720	5.67	0	Cytoplasm;Cytosol	NA	NA	NA	NA	NA	PE2	14
+NX_Q8N7B1	HORMA domain-containing protein 2	307	35284	6.86	0	Nucleus;Chromosome	NA	Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).	Phosphorylated in a SPO11-dependent manner.	NA	NA	PE1	22
+NX_Q8N7B6	PACRG-like protein	248	27152	9.71	0	Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	NA	NA	PE1	4
+NX_Q8N7B9	EF-hand calcium-binding domain-containing protein 3	438	50147	9.31	0	NA	NA	NA	NA	NA	NA	PE1	17
+NX_Q8N7C0	Leucine-rich repeat-containing protein 52	313	35126	5.44	1	Cell membrane	NA	Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties.	N-glycosylated.	NA	NA	PE1	1
+NX_Q8N7C3	Probable E3 ubiquitin-protein ligase TRIML2	387	43983	5.52	0	Cytosol;Cell membrane	NA	NA	NA	NA	Protein modification; protein ubiquitination.	PE1	4
+NX_Q8N7C4	Transmembrane protein 217	229	26582	9.33	4	Membrane;Nucleolus	NA	NA	NA	NA	NA	PE1	6
+NX_Q8N7C7	RING finger protein 148	305	34397	8.49	1	Membrane	NA	NA	NA	NA	NA	PE1	7
+NX_Q8N7E2	E3 ubiquitin-protein ligase CBLL2	425	48785	9.57	0	Cytoplasm	NA	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:20657603). May operate on tyrosine-phosphorylated SRC substrates (PubMed:22252131).	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	X
+NX_Q8N7F7	Ubiquitin-like protein 4B	174	19909	5.63	0	Cytoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_Q8N7G0	POU domain, class 5, transcription factor 2	328	36051	10.11	0	Nucleoplasm;Nucleus	NA	Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).	NA	Belongs to the POU transcription factor family. Class-5 subfamily.	NA	PE1	5
+NX_Q8N7H1	Putative uncharacterized protein encoded by LINC01465	131	13435	11.32	0	NA	NA	NA	NA	NA	NA	PE2	12
+NX_Q8N7H5	RNA polymerase II-associated factor 1 homolog	531	59976	4.53	0	Nucleoplasm;Nucleus	NA	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro.	NA	Belongs to the PAF1 family.	Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins	PE1	19
+NX_Q8N7I0	Protein GVQW1	195	21479	8.73	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q8N7J2	APC membrane recruitment protein 2	671	69507	6.55	0	Cell membrane	NA	Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.	NA	Belongs to the Amer family.	NA	PE1	13
+NX_Q8N7K0	Zinc finger protein 433	673	77243	9.38	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8N7L0	Protein FAM216B	139	16362	11.54	0	NA	NA	NA	NA	Belongs to the FAM216 family.	NA	PE1	13
+NX_Q8N7M0	Tctex1 domain-containing protein 1	179	20730	9.04	0	NA	NA	NA	NA	Belongs to the dynein light chain Tctex-type family.	Intraflagellar transport	PE1	1
+NX_Q8N7M2	Zinc finger protein 283	679	77942	8.62	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8N7N1	Putative protein N-methyltransferase FAM86B1	296	32865	6	0	NA	NA	NA	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.	NA	PE2	8
+NX_Q8N7P1	Inactive phospholipase D5	536	61312	8.93	1	Membrane;Cytoplasmic vesicle;Cytosol;Mitochondrion	NA	NA	NA	Belongs to the phospholipase D family.	NA	PE1	1
+NX_Q8N7P3	Claudin-22	220	24509	5.7	4	Tight junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE2	4
+NX_Q8N7P7	Uncharacterized protein FLJ40521	452	48314	10.01	0	NA	NA	NA	NA	NA	NA	PE2	8
+NX_Q8N7Q2	Putative uncharacterized protein CELF2-AS1	184	20470	9.22	0	Secreted	NA	NA	NA	NA	NA	PE5	10
+NX_Q8N7Q3	Zinc finger protein 676	588	67624	9.1	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q8N7R0	Putative homeobox protein NANOG2	232	26880	9.08	0	Nucleus	NA	Probable transcriptional regulator.	NA	Belongs to the Nanog homeobox family.	NA	PE5	12
+NX_Q8N7R1	POM121-like protein 12	296	31848	9.32	0	NA	NA	NA	NA	Belongs to the POM121 family.	NA	PE1	7
+NX_Q8N7R7	Cyclin-Y-like protein 1	359	40705	5.7	0	Cell membrane	NA	NA	NA	Belongs to the cyclin family. Cyclin Y subfamily.	NA	PE1	2
+NX_Q8N7S2	DnaJ homolog subfamily C member 5G	189	21433	7.92	0	Membrane	NA	NA	Palmitoylated.	NA	Protein processing in endoplasmic reticulum	PE2	2
+NX_Q8N7S6	Uncharacterized protein ARIH2OS	290	30424	11.74	1	Membrane	NA	NA	NA	NA	NA	PE2	3
+NX_Q8N7U6	EF-hand domain-containing family member B	833	93802	7.51	0	Cytoplasm;Nucleolus	NA	Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	NA	NA	NA	PE1	3
+NX_Q8N7U7	Tetra-peptide repeat homeobox protein 1	411	40603	10	0	Nucleus	NA	NA	NA	NA	NA	PE2	19
+NX_Q8N7U9	Putative uncharacterized protein encoded by LINC00469	141	15976	5.8	0	NA	NA	NA	NA	NA	NA	PE5	17
+NX_Q8N7W2	BEN domain-containing protein 7	519	57549	9.26	0	Nucleoplasm;Nucleolus;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	10
+NX_Q8N7X0	Androglobin	1667	189713	8.49	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the peptidase C2 family.	NA	PE1	6
+NX_Q8N7X1	RNA-binding motif protein, X-linked-like-3	1067	114938	9.19	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_Q8N7X2	Protein STPG3	386	42496	10.01	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	9
+NX_Q8N7X4	Melanoma-associated antigen B6	407	43992	5.39	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_Q8N7X8	SIGLEC family-like protein 1	197	21283	9.59	1	Membrane	NA	NA	NA	NA	NA	PE2	19
+NX_Q8N7Y1	Putative uncharacterized protein KIRREL3-AS3	241	25772	10.92	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q8N7Z2	Golgin subfamily A member 6-like protein 1	668	83069	5.25	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE2	15
+NX_Q8N7Z5	Ankyrin repeat domain-containing protein 31	1873	210816	5.82	0	Nucleus;Chromosome	NA	Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes.	NA	NA	NA	PE1	5
+NX_Q8N801	Protein STPG4	248	27807	9.61	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).	NA	NA	NA	PE1	2
+NX_Q8N806	Putative E3 ubiquitin-protein ligase UBR7	425	47999	4.7	0	Nucleoplasm	NA	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	NA	NA	Protein modification; protein ubiquitination.	PE1	14
+NX_Q8N807	Protein disulfide-isomerase-like protein of the testis	584	66657	6.41	0	Endoplasmic reticulum	NA	Probable redox-inactive chaperone involved in spermatogenesis.	N-glycosylated.	Belongs to the protein disulfide isomerase family.	NA	PE1	16
+NX_Q8N808	Solute carrier family 35 member G3	338	35381	6.63	9	Membrane	NA	NA	NA	Belongs to the SLC35G solute transporter family.	NA	PE2	17
+NX_Q8N812	Uncharacterized protein C12orf76	135	14959	6.63	0	Cytoskeleton;Cell membrane	NA	NA	NA	NA	NA	PE2	12
+NX_Q8N813	Putative uncharacterized protein C3orf56	242	26007	8.48	0	NA	NA	NA	NA	NA	NA	PE2	3
+NX_Q8N814	Putative uncharacterized protein FLJ40140	137	14437	5.26	0	NA	NA	NA	NA	NA	NA	PE5	7
+NX_Q8N815	Cyclin N-terminal domain-containing protein 1	330	36921	6.46	0	Nucleoplasm;Focal adhesion;Cell membrane	NA	NA	NA	NA	NA	PE2	17
+NX_Q8N816	Transmembrane protein 99	258	27975	6.33	3	Membrane	NA	NA	NA	NA	NA	PE2	17
+NX_Q8N819	Probable protein phosphatase 1N	430	46170	6.21	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the PP2C family.	NA	PE2	19
+NX_Q8N823	Zinc finger protein 611	705	81449	9.16	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8N831	Testis-specific Y-encoded-like protein 6	410	45874	5.45	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	2
+NX_Q8N841	Tubulin polyglutamylase TTLL6	843	96401	9.03	0	Cytoplasmic vesicle;Cilium;Cilium basal body;Cytoskeleton	NA	Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS.	NA	Belongs to the tubulin--tyrosine ligase family.	Carboxyterminal post-translational modifications of tubulin	PE1	17
+NX_Q8N859	Zinc finger protein 713	430	50172	6.51	0	Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q8N865	Uncharacterized protein C7orf31	590	68464	6.9	0	Nucleoplasm;Centrosome;Mitochondrion	NA	NA	NA	NA	NA	PE1	7
+NX_Q8N878	FERM domain-containing protein 1	549	62523	8.52	0	Cytoskeleton	NA	NA	NA	NA	NA	PE2	6
+NX_Q8N883	Zinc finger protein 614	585	67215	9.25	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus;Cytosol	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8N884	Cyclic GMP-AMP synthase	522	58814	9.54	0	Cytosol;Centriolar satellite;Nucleus;Cell membrane	NA	Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23258413, PubMed:23707061, PubMed:23722159, PubMed:24077100, PubMed:25131990, PubMed:29976794, PubMed:30799039). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Preferentially recognizes and binds curved long DNAs (PubMed:30007416). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less cyclic GMP-AMP (cGAMP), allowing a more fine-tuned response to pathogens (PubMed:30007416). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-1, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). CGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells (PubMed:24077100). CGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). In addition to antiviral activity, also involved in the response to cellular stresses, such as senescence, DNA damage or genome instability (PubMed:28738408, PubMed:28759889). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via TMEM173/STING and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which as frequently found in cancer cells, consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to cGAMP synthesis and subsequent activation of TMEM173/STING and type-I interferon production (PubMed:28738408, PubMed:28759889). Acts as a suppressor of DNA repair in response to DNA damage: translocates to the nucleus following dephosphorylation at Tyr-215 and inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214).	(Microbial infection) Deamidated on 'Asn-210' by herpes simplex virus 1 protein UL37. This modification significantly reduces CGAS-dependent cGAMP production and innate immune signaling induced by dsDNA.;Phosphorylation at Tyr-215 by BLK promotes cytosolic retention (PubMed:30356214). Translocates into the nucleus following dephosphorylation at Tyr-215 (PubMed:30356214).;Polyglutamylated by TTLL6 at Glu-286, leading to impair DNA-binding activity. Monoglutamylated at Glu-314 by TTLL4, leading to impair the nucleotidyltransferase activity. Deglutamylated by AGBL5/CCP5 and AGBL6/CCP6.;Cleaved by CASP1 at Asp-140 and Asp-157 upon DNA virus infection; the cleavage impairs cGAMP production (PubMed:28314590). Also cleaved by the pyroptotic CASP4 and CASP5 during non-canonical inflammasome activation; they don't cut at the same sites than CASP1 (PubMed:28314590).;Acetylation at Lys-384, Lys-394 and Lys-414 inhibits the cyclic GMP-AMP synthase activity (PubMed:30799039). Deacetylated upon cytosolic DNA challenge such as viral infections (PubMed:30799039). Acetylation can be mediated by aspirin (acetylsalicylate) drug, which directly acetylates CGAS (PubMed:30799039). Acetylation by aspirin efficiently inhibits CGAS-mediated immune responses and is able to suppress self-DNA-induced autoimmunity (PubMed:30799039).	Belongs to the mab-21 family.	STING mediated induction of host immune responses	PE1	6
+NX_Q8N888	Putative BCoR-like protein 2	145	16258	9.12	0	NA	NA	NA	NA	Belongs to the BCOR family.	NA	PE5	Y
+NX_Q8N895	Zinc finger protein 366	744	85107	8.88	0	Nucleus	NA	Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.	NA	NA	NA	PE1	5
+NX_Q8N8A2	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B	993	107603	5.85	0	Nucleus speckle;Mitochondrion	NA	Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.	NA	NA	NA	PE1	2
+NX_Q8N8A6	ATP-dependent RNA helicase DDX51	666	72457	8.43	0	Nucleoplasm;Cytosol;Nucleolus	NA	ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.	NA	Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.	NA	PE1	12
+NX_Q8N8A8	Protein FAM169B	192	21411	5.58	0	NA	NA	NA	NA	Belongs to the FAM169 family.	NA	PE2	15
+NX_Q8N8B7	Transcription elongation factor A N-terminal and central domain-containing protein	351	40245	8.86	0	Nucleus speckle	NA	NA	NA	NA	NA	PE1	X
+NX_Q8N8C0	Zinc finger protein 781	355	41526	10.4	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE2	19
+NX_Q8N8D1	Programmed cell death protein 7	485	54700	9.97	0	Nucleus;Nucleolus;Cell membrane	NA	Promotes apoptosis when overexpressed.	NA	NA	mRNA Splicing - Minor Pathway	PE1	15
+NX_Q8N8D7	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3	197	22620	5.41	4	Cell membrane	NA	NA	NA	Belongs to the NKAIN family.	NA	PE2	8
+NX_Q8N8D9	Uncharacterized protein C5orf56	126	14652	6.77	0	NA	NA	NA	NA	NA	NA	PE2	5
+NX_Q8N8E1	Putative uncharacterized protein encoded by MAPKAPK5-AS1	139	13175	11.41	0	NA	NA	NA	NA	NA	NA	PE5	12
+NX_Q8N8E2	Zinc finger protein 513	541	57882	7.49	0	Nucleus	Retinitis pigmentosa 58	Transcriptional regulator that plays a role in retinal development and maintenance.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	2
+NX_Q8N8E3	Centrosomal protein of 112 kDa	955	112749	6.25	0	Golgi apparatus;Nucleoplasm;Centrosome	NA	NA	NA	NA	NA	PE1	17
+NX_Q8N8F6	Protein YIPF7	280	30632	4.76	5	trans-Golgi network membrane;Endoplasmic reticulum membrane;cis-Golgi network membrane	NA	NA	NA	Belongs to the YIP1 family.	NA	PE1	4
+NX_Q8N8F7	Leucine-rich single-pass membrane protein 1	131	14462	5.22	1	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	7
+NX_Q8N8G2	Transcription cofactor vestigial-like protein 2	317	33426	6.33	0	Nucleus	NA	May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.	NA	Belongs to the vestigial family.	NA	PE1	6
+NX_Q8N8G6	Putative uncharacterized protein C15orf54	183	21040	9.87	0	NA	NA	NA	NA	NA	NA	PE2	15
+NX_Q8N8H1	Putative protein ZNF321	164	18964	6.49	0	Nucleoplasm	NA	NA	NA	NA	NA	PE5	19
+NX_Q8N8I0	Sterile alpha motif domain-containing protein 12	201	22907	9.4	0	Golgi apparatus;Cytosol	Epilepsy, familial adult myoclonic, 1	NA	NA	NA	NA	PE1	8
+NX_Q8N8I6	Putative uncharacterized protein encoded by LINC00482	264	28326	11.2	0	NA	NA	NA	NA	NA	NA	PE5	17
+NX_Q8N8J0	Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1	262	29179	6.83	0	NA	NA	NA	NA	Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.	NA	PE5	22
+NX_Q8N8J6	Zinc finger protein 615	731	83739	9.35	0	Nucleolus;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8N8J7	Uncharacterized protein FAM241A	132	14653	4.6	1	Membrane;Golgi apparatus	NA	NA	NA	Belongs to the FAM241 family.	NA	PE1	4
+NX_Q8N8K9	Uncharacterized protein KIAA1958	716	79212	6.38	0	Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	9
+NX_Q8N8L2	Zinc finger protein 491	437	50950	9.45	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE2	19
+NX_Q8N8L6	ADP-ribosylation factor-like protein 10	244	27459	4.58	0	NA	NA	NA	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	5
+NX_Q8N8M0	Probable N-acetyltransferase 16	369	40521	6.49	0	Nucleoplasm	NA	Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown.	NA	NA	NA	PE1	7
+NX_Q8N8N0	E3 ubiquitin-protein ligase RNF152	203	22357	8.2	1	Lysosome membrane	NA	E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).	Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable).	Belongs to the RNF152 family.	Protein modification; protein ubiquitination.;E3 ubiquitin ligases ubiquitinate target proteins	PE1	18
+NX_Q8N8N7	Prostaglandin reductase 2	351	38499	5.27	0	Cytoplasmic vesicle;Cytoplasm	NA	Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).	NA	Belongs to the NADP-dependent oxidoreductase L4BD family.	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	PE1	14
+NX_Q8N8P6	Putative uncharacterized protein FLJ39060	123	13896	9.36	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_Q8N8P7	Uncharacterized protein C11orf44	122	13691	5.58	0	Secreted	NA	NA	NA	NA	NA	PE2	11
+NX_Q8N8Q1	Cytochrome b561 domain-containing protein 1	229	25424	10.02	6	Membrane	NA	NA	NA	NA	NA	PE2	1
+NX_Q8N8Q3	Endonuclease V	282	30792	8.34	0	Cytoplasm;Nucleolus	NA	Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.	NA	Belongs to the endonuclease V family.	NA	PE1	17
+NX_Q8N8Q8	Cytochrome c oxidase assembly protein COX18, mitochondrial	333	37063	9.86	3	Mitochondrion inner membrane	NA	Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase).	NA	Belongs to the OXA1/ALB3/YidC family.	Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	4
+NX_Q8N8Q9	Magnesium transporter NIPA2	360	39185	8.46	9	Golgi apparatus;Early endosome;Cell membrane	NA	Acts as a selective Mg(2+) transporter.	NA	Belongs to the NIPA family.	Miscellaneous transport and binding events	PE1	15
+NX_Q8N8R3	Mitochondrial basic amino acids transporter	303	32062	9.03	6	Mitochondrion inner membrane	NA	Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine (PubMed:24652292). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 (PubMed:19287344). Does not transport carnitine nor acylcarnitines (PubMed:24652292). Functions by both counter-exchange and uniport mechanisms (PubMed:24652292).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Amino acid transport across the plasma membrane	PE1	14
+NX_Q8N8R5	UPF0565 protein C2orf69	385	43448	8.31	0	Secreted	NA	NA	NA	Belongs to the UPF0565 family.	NA	PE1	2
+NX_Q8N8R7	ARL14 effector protein	260	29338	8.42	0	Cytoplasm;Focal adhesion;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.	NA	NA	NA	PE1	11
+NX_Q8N8S7	Protein enabled homolog	591	66510	6.51	0	Cytoplasm;Cell membrane;Focal adhesion;Lamellipodium;Filopodium;Synapse;Cytosol;Cytoskeleton	NA	Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).	NTN1-induced PKA phosphorylation on Ser-265 directly parallels the formation of filopodial protrusions.	Belongs to the Ena/VASP family.	Regulation of actin cytoskeleton;Generation of second messenger molecules;Signaling by ROBO receptors	PE1	1
+NX_Q8N8U2	Chromodomain Y-like protein 2	506	56500	8.99	0	Nucleus	NA	NA	NA	NA	NA	PE1	16
+NX_Q8N8U3	Retrotransposon Gag-like protein 3	475	52817	4.43	0	Golgi apparatus;Nucleoplasm;Nucleus;Cell membrane	NA	May function as a transcriptional regulator. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.	NA	NA	NA	PE2	X
+NX_Q8N8U9	BMP-binding endothelial regulator protein	685	75997	8.18	0	Secreted	Diaphanospondylodysostosis	Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.	NA	NA	NA	PE1	7
+NX_Q8N8V2	Guanylate-binding protein 7	638	72513	5.72	0	Membrane	NA	Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	Interferon gamma signaling	PE1	1
+NX_Q8N8V4	Ankyrin repeat and SAM domain-containing protein 4B	417	46597	4.99	0	Nucleoplasm;Cytosol;Microvillus	NA	As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed:26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity).	NA	NA	NA	PE1	16
+NX_Q8N8V8	Transmembrane protein 105	129	13990	11.62	2	Membrane	NA	NA	NA	NA	NA	PE2	17
+NX_Q8N8W4	Patatin-like phospholipase domain-containing protein 1	532	57875	8.35	0	Cytoplasm;Cytoskeleton	Ichthyosis, congenital, autosomal recessive 10	Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in glycerophospholipid metabolism.	NA	NA	NA	PE1	6
+NX_Q8N8X9	Protein mab-21-like 3	362	42357	8.84	0	Nucleoplasm	NA	NA	NA	Belongs to the mab-21 family.	NA	PE1	1
+NX_Q8N8Y2	V-type proton ATPase subunit d 2	350	40426	5.18	0	Cytoplasmic vesicle	NA	Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity).	NA	Belongs to the V-ATPase V0D/AC39 subunit family.	Oxidative phosphorylation;Metabolic pathways;Lysosome;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Tuberculosis;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	8
+NX_Q8N8Y5	Zinc finger protein 41 homolog	198	22806	9.46	0	Nucleoplasm;Nucleus;Nucleolus;Cell membrane	NA	A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_Q8N8Z3	Proline-rich protein 26	221	24207	11.22	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_Q8N8Z6	Discoidin, CUB and LCCL domain-containing protein 1	715	77920	8.26	1	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	6
+NX_Q8N8Z8	Zinc finger protein 441	693	80136	8.82	0	Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8N907	DAN domain family member 5	189	20180	9.89	0	Mitochondrion;Secreted	NA	Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).	NA	Belongs to the DAN family.	Signaling by NODAL;Regulation of signaling by NODAL	PE1	19
+NX_Q8N910	Putative uncharacterized protein C15orf56	161	17040	11.89	0	NA	NA	NA	NA	NA	NA	PE2	15
+NX_Q8N912	Nutritionally-regulated adipose and cardiac enriched protein homolog	160	18051	11.21	1	Cell membrane	NA	NA	NA	NA	NA	PE2	14
+NX_Q8N944	APC membrane recruitment protein 3	861	90445	5.48	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity).	NA	Belongs to the Amer family.	NA	PE1	2
+NX_Q8N945	PRELI domain-containing protein 2	189	21905	8.98	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	5
+NX_Q8N954	G patch domain-containing protein 11	285	33277	5.68	0	Nucleoplasm;Kinetochore	NA	NA	NA	Belongs to the GPATCH11 family.	NA	PE1	2
+NX_Q8N957	Ankyrin repeat and fibronectin type-III domain-containing protein 1	763	87604	8.69	0	NA	NA	NA	NA	NA	NA	PE1	17
+NX_Q8N960	Centrosomal protein of 120 kDa	986	112640	5.9	0	Cytosol;Centrosome;Cytoskeleton	Short-rib thoracic dysplasia 13 with or without polydactyly;Joubert syndrome 31	Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865).	NA	Belongs to the CEP120 family.	NA	PE1	5
+NX_Q8N961	Ankyrin repeat and BTB/POZ domain-containing protein 2	1025	113656	5.87	0	Nucleoplasm	NA	May be involved in the initiation of hepatocyte growth.	NA	NA	NA	PE1	11
+NX_Q8N966	Palmitoyltransferase ZDHHC22	263	29100	9.5	2	Membrane;Cell membrane	NA	Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (PubMed:22399288). Might also mediate palmitoylation of CNN3 (By similarity).	NA	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	14
+NX_Q8N967	Leucine-rich repeat and transmembrane domain-containing protein 2	370	41158	8.17	1	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	12
+NX_Q8N972	Zinc finger protein 709	641	74652	9.22	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8N976	Putative uncharacterized protein FLJ38264	141	14881	6.53	0	NA	NA	NA	NA	NA	NA	PE5	7
+NX_Q8N983	39S ribosomal protein L43, mitochondrial	215	23431	8.97	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL43 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	10
+NX_Q8N987	N-terminal EF-hand calcium-binding protein 1	351	40571	4.83	0	Nucleoplasm;Cytoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	8
+NX_Q8N988	Zinc finger protein 557	423	48627	9.22	0	Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8N998	Coiled-coil domain-containing protein 89	374	43809	5.33	0	Nucleoplasm;Cytoplasm;Nucleus	NA	NA	NA	Belongs to the CCDC89 family.	NA	PE1	11
+NX_Q8N999	Uncharacterized protein C12orf29	325	37490	6.6	0	Cytoplasm;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	12
+NX_Q8N9A8	Nuclear envelope phosphatase-regulatory subunit 1	125	14267	8.71	2	Cytoplasm;Cytosol;Nucleus membrane	NA	Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol.	NA	Belongs to the CNEP1R1 family.	Depolymerisation of the Nuclear Lamina	PE1	16
+NX_Q8N9B4	Ankyrin repeat domain-containing protein 42	389	43052	6.01	0	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	11
+NX_Q8N9B5	Junction-mediating and -regulatory protein	988	111445	5.88	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).	Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response (By similarity).	Belongs to the JMY family.	Regulation of TP53 Activity through Methylation	PE1	5
+NX_Q8N9B8	Ras-GEF domain-containing family member 1A	481	54556	7.6	0	Golgi apparatus	NA	Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration.	NA	NA	RAF/MAP kinase cascade	PE1	10
+NX_Q8N9C0	Immunoglobulin superfamily member 22	903	100400	6.7	0	NA	NA	NA	NA	NA	NA	PE2	11
+NX_Q8N9E0	Protein FAM133A	248	28941	10.1	0	NA	NA	NA	NA	Belongs to the FAM133 family.	NA	PE1	X
+NX_Q8N9F0	N-acetylaspartate synthetase	302	32837	9.05	1	Microsome membrane;Cytoplasm;Mitochondrion;Membrane;Rough endoplasmic reticulum membrane;Mitochondrion membrane	N-acetylaspartate deficiency	Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake.	NA	Belongs to the camello family.	Aspartate and asparagine metabolism	PE1	4
+NX_Q8N9F7	Lysophospholipase D GDPD1	314	36167	8.66	2	Membrane;Cytoplasm;Perinuclear region	NA	Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.	NA	Belongs to the glycerophosphoryl diester phosphodiesterase family.	Glycerophospholipid catabolism	PE1	17
+NX_Q8N9F8	Zinc finger protein 454	522	60008	8.96	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	5
+NX_Q8N9G6	Putative UPF0607 protein FLJ37424	341	37462	10.42	0	NA	NA	NA	NA	Belongs to the UPF0607 family.	NA	PE2	10
+NX_Q8N9H6	Putative uncharacterized protein C8orf31	132	14527	9.23	0	NA	NA	NA	NA	NA	NA	PE5	8
+NX_Q8N9H8	Exonuclease mut-7 homolog	876	96598	8.6	0	Focal adhesion;Cytoskeleton	NA	Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity).	NA	Belongs to the mut-7 family.	NA	PE1	9
+NX_Q8N9H9	Uncharacterized protein C1orf127	656	69787	5.32	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q8N9I0	Synaptotagmin-2	419	46872	8.18	1	Synaptic vesicle membrane;Chromaffin granule membrane	Myasthenic syndrome, congenital, 7, presynaptic	Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).	NA	Belongs to the synaptotagmin family.	Toxicity of botulinum toxin type B (BoNT/B);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Neurexins and neuroligins	PE1	1
+NX_Q8N9I5	Fatty acid desaturase 6	356	40447	8.13	6	Membrane	NA	NA	NA	Belongs to the fatty acid desaturase type 1 family.	Lipid metabolism; fatty acid metabolism.	PE2	17
+NX_Q8N9I9	Probable E3 ubiquitin-protein ligase DTX3	347	37988	9.02	0	Golgi apparatus;Nucleoplasm;Cytoplasm;Nucleolus	NA	Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.	NA	Belongs to the Deltex family.	Protein modification; protein ubiquitination.;Notch signaling pathway	PE1	12
+NX_Q8N9K5	Zinc finger protein 565	539	62445	8.58	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8N9L1	Zinc finger protein ZIC 4	334	36567	9.61	0	Nucleoplasm;Cytosol;Nucleus	NA	Binds to DNA.	NA	Belongs to the GLI C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q8N9L7	Putative uncharacterized protein FLJ36925	120	13535	9.8	0	NA	NA	NA	NA	NA	NA	PE5	22
+NX_Q8N9L9	Peroxisomal succinyl-coenzyme A thioesterase	421	46327	8.31	0	Peroxisome	NA	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). ACOT4 is a peroxisomal succinyl-coenzyme A thioesterase can also hydrolyze glutaryl-CoA and long chain saturated acyl-CoAs (PubMed:16940157).	NA	Belongs to the C/M/P thioester hydrolase family.	Lipid metabolism; fatty acid biosynthesis.;Fatty acid elongation;Biosynthesis of unsaturated fatty acids;Beta-oxidation of very long chain fatty acids;Peroxisomal protein import	PE1	14
+NX_Q8N9M1	Uncharacterized protein C19orf47	422	44746	10.12	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	19
+NX_Q8N9M5	Transmembrane protein 102	508	54175	5.59	1	Cytoplasmic vesicle;Cell membrane	NA	Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.	NA	NA	NA	PE1	17
+NX_Q8N9N2	Activating signal cointegrator 1 complex subunit 1	400	45509	5.36	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleus	Barrett esophagus;Spinal muscular atrophy with congenital bone fractures 2	Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.	NA	NA	ALKBH3 mediated reversal of alkylation damage	PE1	10
+NX_Q8N9N5	Protein BANP	519	56494	5.27	0	Nucleoplasm;Nucleus	NA	Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).	NA	Belongs to the BANP/SMAR1 family.	Regulation of TP53 Activity through Association with Co-factors	PE1	16
+NX_Q8N9N7	Leucine-rich repeat-containing protein 57	239	26754	8.7	0	Membrane;Cytosol;Mitochondrion	NA	NA	NA	NA	NA	PE1	15
+NX_Q8N9N8	Probable RNA-binding protein EIF1AD	165	19053	5.14	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Plays a role into cellular response to oxidative stress. Decreases cell proliferation.	NA	Belongs to the EIF1AD family.	NA	PE1	11
+NX_Q8N9P0	Putative uncharacterized protein FLJ36797	234	25159	11.75	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_Q8N9P6	Uncharacterized protein C9orf163	203	22154	11.66	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q8N9Q2	Protein SREK1IP1	155	18177	9.86	0	Nucleoplasm;Nucleolus	NA	Possible splicing regulator involved in the control of cellular survival.	NA	NA	NA	PE1	5
+NX_Q8N9R0	Putative uncharacterized protein encoded by LINC00304	145	15610	11.42	0	NA	NA	NA	NA	NA	NA	PE5	16
+NX_Q8N9R6	CMT1A duplicated region transcript 4 protein	152	17643	9.96	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	17
+NX_Q8N9R8	Protein SCAI	606	70399	8.78	1	Cytoplasm;Nucleus membrane;Membrane;Nucleoplasm;Nucleus	NA	Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.	NA	Belongs to the SCAI family.	RHO GTPases Activate Formins	PE1	9
+NX_Q8N9S9	Sorting nexin-31	440	50802	6.62	0	Nucleoplasm;Golgi apparatus;Cytosol	NA	May be involved in protein trafficking.	NA	Belongs to the sorting nexin family.	NA	PE1	8
+NX_Q8N9T2	Putative uncharacterized protein CXorf42	125	14163	9.29	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_Q8N9T8	Protein KRI1 homolog	703	82598	5.06	0	Nucleolus	NA	NA	NA	Belongs to the KRI1 family.	NA	PE1	19
+NX_Q8N9U0	Tandem C2 domains nuclear protein	490	55284	9.29	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	14
+NX_Q8N9U9	Putative uncharacterized protein SPANXA2-OT1	137	13254	12.18	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_Q8N9V2	Probable E3 ubiquitin-protein ligase TRIML1	468	53002	5.36	0	NA	NA	Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.	NA	NA	Protein modification; protein ubiquitination.	PE1	4
+NX_Q8N9V3	WD repeat, SAM and U-box domain-containing protein 1	476	52817	5.93	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	2
+NX_Q8N9V6	Ankyrin repeat domain-containing protein 53	530	59571	9.58	0	Spindle pole;Spindle	NA	Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.	Phosphorylated during mitosis (PubMed:26820536).	NA	NA	PE1	2
+NX_Q8N9V7	Protein TOPAZ1	1692	190927	8.16	0	Cytosol	NA	Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.	NA	NA	NA	PE1	3
+NX_Q8N9W4	Golgin subfamily A member 6-like protein 2	909	100610	4.63	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE1	15
+NX_Q8N9W5	Dynein assembly factor 3, axonemal	541	59410	5.66	0	Cytoplasm;Mitochondrion;Nucleus	Ciliary dyskinesia, primary, 2	Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.	NA	Belongs to the DNAAF3 family.	NA	PE1	19
+NX_Q8N9W6	Protein boule-like	283	31301	6.59	0	Cytoplasm	NA	Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity).	NA	Belongs to the RRM DAZ family.	NA	PE1	2
+NX_Q8N9W7	Putative transmembrane protein FLJ36131	124	13731	8.96	1	Membrane	NA	NA	NA	NA	NA	PE5	15
+NX_Q8N9W8	Protein FAM71D	422	47076	5.6	0	NA	NA	NA	NA	Belongs to the FAM71 family.	NA	PE1	14
+NX_Q8N9X3	Putative uncharacterized protein encoded by LINC01356	169	18887	11.31	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q8N9X5	Putative transmembrane protein 75	138	15361	8.88	2	Membrane;Cytoplasm;Cell membrane	NA	NA	NA	NA	NA	PE5	8
+NX_Q8N9Y4	Protein FAM181A	354	38724	9.75	0	NA	NA	NA	NA	Belongs to the FAM181 family.	NA	PE1	14
+NX_Q8N9Z0	Zinc finger protein 610	462	53489	9.36	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8N9Z2	Coiled-coil domain-containing protein 71L	235	26261	11.71	0	Golgi apparatus;Cytosol;Cytoskeleton	NA	NA	NA	NA	NA	PE1	7
+NX_Q8N9Z9	Lamin tail domain-containing protein 1	388	43408	9.18	0	Nucleoplasm;Centrosome	NA	NA	NA	Belongs to the intermediate filament family.	NA	PE1	12
+NX_Q8NA03	Fibrous sheath-interacting protein 1	581	66121	5.08	0	Nucleoplasm	NA	NA	NA	Belongs to the FSIP1 family.	NA	PE1	15
+NX_Q8NA19	Lethal(3)malignant brain tumor-like protein 4	623	71122	7.11	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity).	NA	NA	NA	PE1	18
+NX_Q8NA23	WD repeat-containing protein 31	367	40840	8.65	0	Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	9
+NX_Q8NA29	Sodium-dependent lysophosphatidylcholine symporter 1	543	60170	6.51	11	Cytosol;Endoplasmic reticulum membrane;Cell membrane	Microcephaly 15, primary, autosomal recessive	Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By similarity). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed:26005868). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation (PubMed:21677192). In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732, PubMed:23177091).	N-glycosylated.	Belongs to the major facilitator superfamily.	Synthesis of PC	PE1	1
+NX_Q8NA31	Telomere repeats-binding bouquet formation protein 1	727	83064	7.29	0	Nucleus inner membrane;Telomere	NA	Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.	Phosphorylated by CDK. Phosphorylation by CDK takes place in late prophase when the cap exchange is prominent. Is important for the stabilization of telomere attachment but dispenable for the cap exchange.	Belongs to the TERB1 family.	NA	PE1	16
+NX_Q8NA42	Zinc finger protein 383	475	54613	8.21	0	Nucleoplasm;Cytoplasm;Nucleus membrane;Nucleus	NA	May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8NA47	Coiled-coil domain-containing protein 63	563	66250	9.08	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads.	NA	NA	NA	PE1	12
+NX_Q8NA54	IQ and ubiquitin-like domain-containing protein	791	92581	6.21	0	Cytosol;Nucleus speckle;Cytoskeleton	NA	May play roles in cilia formation and/or maintenance.	NA	NA	NA	PE1	7
+NX_Q8NA56	Tetratricopeptide repeat protein 29	475	55082	5.5	0	NA	NA	NA	NA	NA	NA	PE1	4
+NX_Q8NA57	Uncharacterized protein C12orf50	414	47326	8.79	0	NA	NA	NA	NA	NA	NA	PE1	12
+NX_Q8NA58	Poly(A)-specific ribonuclease PNLDC1	520	60124	8.82	1	Endoplasmic reticulum membrane	NA	3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (By similarity).	NA	Belongs to the CAF1 family.	NA	PE1	6
+NX_Q8NA61	Spermatid-associated protein	448	51570	6.7	0	Cell junction;Cell membrane	NA	NA	NA	Belongs to the chibby family. SPERT subfamily.	NA	PE1	13
+NX_Q8NA66	Cyclic nucleotide-binding domain-containing protein 1	436	50224	9.15	0	NA	NA	NA	NA	NA	NA	PE1	8
+NX_Q8NA69	Testis-expressed protein 45	505	57331	9.04	0	NA	NA	NA	NA	NA	NA	PE1	19
+NX_Q8NA70	Protein FAM47B	645	73945	8.96	0	NA	NA	NA	NA	Belongs to the FAM47 family.	NA	PE1	X
+NX_Q8NA72	Centrosomal protein POC5	575	63351	6.97	0	Nucleoplasm;Centrosome;Centriole	NA	Essential for the assembly of the distal half of centrioles, required for centriole elongation.	Hyperphosphorylated during recruitment to procentrioles in G2/M phase.	Belongs to the POC5 family.	NA	PE1	5
+NX_Q8NA75	DDB1- and CUL4-associated factor 4-like protein 2	395	43747	8.85	0	NA	NA	NA	NA	NA	NA	PE1	8
+NX_Q8NA77	Testis-expressed protein 19	164	18469	3.85	0	Cytoplasm	NA	Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retranstoposon mobilization (PubMed:28806172).	NA	NA	NA	PE1	17
+NX_Q8NA82	Probable E3 ubiquitin-protein ligase MARCH10	808	90511	6.26	0	Cytosol;Cell membrane	NA	E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.	NA	NA	Protein modification; protein ubiquitination.	PE1	17
+NX_Q8NA92	THAP domain-containing protein 8	274	30082	10.24	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q8NA96	Putative uncharacterized protein FLJ35723	180	19635	8.97	0	NA	NA	NA	NA	NA	NA	PE5	5
+NX_Q8NA97	Putative uncharacterized protein FER1L6-AS1	138	15156	8.17	0	NA	NA	NA	NA	NA	NA	PE2	8
+NX_Q8NAA4	Autophagy-related protein 16-2	619	68998	9.2	0	Cytoplasm;Nucleoplasm	NA	May play a role in autophagy.	NA	Belongs to the WD repeat ATG16 family.	NA	PE1	11
+NX_Q8NAA5	Leucine-rich repeat-containing protein 75A	344	37780	8.66	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	Belongs to the LRRC75 family.	NA	PE1	17
+NX_Q8NAA6	Putative uncharacterized protein encoded by LINC02694	179	19737	9.93	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_Q8NAB2	Kelch repeat and BTB domain-containing protein 3	612	69839	5.18	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_Q8NAC3	Interleukin-17 receptor C	791	86240	5.73	1	Cell membrane	Candidiasis, familial, 9	Does not bind IL17A or IL17F.;Receptor for both IL17A and IL17F.;Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).;Receptor for both IL17A and IL17F.;Does not bind IL17A or IL17F.	NA	NA	Interleukin-17 signaling	PE1	3
+NX_Q8NAE3	Putative uncharacterized protein encoded by LINC01555	123	13125	6.11	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q8NAF0	Zinc finger protein 579	562	60509	9.07	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8NAG6	Ankyrin repeat and LEM domain-containing protein 1	615	66890	5.98	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Endonuclease that probably plays a role in the DNA damage response and DNA repair.	NA	NA	NA	PE1	19
+NX_Q8NAJ2	Putative uncharacterized protein C9orf106	232	25113	8.89	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q8NAM6	Zinc finger and SCAN domain-containing protein 4	433	48957	6.47	0	Telomere;Nucleus	NA	Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).	NA	NA	NA	PE1	19
+NX_Q8NAN2	Mitoguardin 1	632	71006	5.42	1	Mitochondrion outer membrane;Mitochondrion	NA	Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.	NA	Belongs to the mitoguardin family.	Synthesis of PA	PE1	1
+NX_Q8NAP1	Putative protein CASTOR 3	163	17846	8.78	0	NA	NA	NA	NA	Belongs to the GATS family.	NA	PE5	7
+NX_Q8NAP3	Zinc finger and BTB domain-containing protein 38	1195	134257	8.34	0	Nucleoplasm;Nucleus;Chromosome	NA	Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).	Ubiquitinated by RBBP6; leading to its degradation by the proteasome.	NA	NA	PE1	3
+NX_Q8NAP8	Zinc finger and BTB domain-containing protein 8B	495	54175	4.98	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	1
+NX_Q8NAQ8	Putative uncharacterized protein FLJ34945	132	14168	11.48	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_Q8NAS9	Putative uncharacterized protein C5orf17	161	17397	4.87	0	NA	NA	NA	NA	NA	NA	PE5	5
+NX_Q8NAT1	Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2	580	66615	8.81	1	Endoplasmic reticulum membrane	Muscular dystrophy-dystroglycanopathy limb-girdle C8;Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A8	O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.	NA	Belongs to the glycosyltransferase 61 family.	Protein modification; protein glycosylation.;O-linked glycosylation	PE1	3
+NX_Q8NAT2	Tudor domain-containing protein 5	981	109737	8.31	0	Cytoplasm	NA	Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).	NA	Belongs to the TDRD5 family.	NA	PE1	1
+NX_Q8NAU1	Fibronectin type III domain-containing protein 5	212	23659	6.91	1	Peroxisome membrane;Secreted;Cell membrane	NA	Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.	N-Glycosylated.;The extracellular domain is cleaved and released from the cell membrane.	NA	NA	PE1	1
+NX_Q8NAV1	Pre-mRNA-splicing factor 38A	312	37477	9.97	0	Nucleoplasm;Nucleus	NA	Involved in pre-mRNA splicing as a component of the spliceosome.	NA	Belongs to the PRP38 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	1
+NX_Q8NAV2	Uncharacterized protein C8orf58	365	39661	8.52	0	Nucleus	NA	NA	NA	NA	NA	PE2	8
+NX_Q8NAX2	Keratinocyte differentiation factor 1	398	43642	6.1	0	Nucleoplasm;Spindle;Cell junction;Cytoplasm	Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type	Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity).	NA	NA	NA	PE1	1
+NX_Q8NB12	Histone-lysine N-methyltransferase SMYD1	490	56617	6.66	0	Cytoplasm;Nucleus	NA	Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE1	2
+NX_Q8NB14	Ubiquitin carboxyl-terminal hydrolase 38	1042	116546	5.82	0	Nucleoplasm;Cytosol;Centrosome	NA	Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked ubiquitin chains.	NA	Belongs to the peptidase C19 family.	NA	PE1	4
+NX_Q8NB15	Zinc finger protein 511	252	28265	7.6	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	10
+NX_Q8NB16	Mixed lineage kinase domain-like protein	471	54479	9	0	Cytoplasm;Cell membrane	NA	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).	Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.	Belongs to the protein kinase superfamily.	TRP channels;RIPK1-mediated regulated necrosis	PE1	16
+NX_Q8NB25	Protein FAM184A	1140	132965	5.59	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the FAM184 family.	NA	PE1	6
+NX_Q8NB37	Glutamine amidotransferase-like class 1 domain-containing protein 1	220	23298	6.14	0	Nucleoplasm;Secreted	NA	NA	NA	Belongs to the peptidase C56 family.	NA	PE1	11
+NX_Q8NB42	Zinc finger protein 527	609	70902	8.35	0	Golgi apparatus;Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8NB46	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C	1076	115077	6.01	0	Nucleoplasm;Mitochondrion	NA	Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.	NA	NA	NA	PE1	12
+NX_Q8NB49	Phospholipid-transporting ATPase IG	1132	129477	6.25	10	Endoplasmic reticulum membrane;Cell membrane	Hemolytic anemia, congenital, X-linked	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages (PubMed:26944472). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity).	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases	PE1	X
+NX_Q8NB50	Zinc finger protein 62 homolog	900	102511	9.24	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	May play a role in differentiating skeletal muscle.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	5
+NX_Q8NB59	Synaptotagmin-14	555	62287	6.02	1	Membrane;Cytoplasmic vesicle	Spinocerebellar ataxia, autosomal recessive, 11	May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.	NA	Belongs to the synaptotagmin family.	NA	PE1	1
+NX_Q8NB66	Protein unc-13 homolog C	2214	250911	5.64	0	Membrane;Cytoplasm;Presynaptic cell membrane	NA	May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity).	NA	Belongs to the unc-13 family.	Synaptic vesicle cycle	PE1	15
+NX_Q8NB78	Lysine-specific histone demethylase 1B	822	92098	8.13	0	Nucleoplasm;Nucleus	NA	Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.	NA	Belongs to the flavin monoamine oxidase family.	HDMs demethylate histones;UCH proteinases	PE1	6
+NX_Q8NB90	ATPase family protein 2 homolog	893	97904	5.5	0	Cytoplasm;Cytosol;Mitochondrion	Epilepsy, hearing loss, and mental retardation syndrome	ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes. May be involved in morphological and functional mitochondrial transformations during spermatogenesis.	NA	Belongs to the AAA ATPase family. AFG2 subfamily.	Ribosome biogenesis in eukaryotes	PE1	4
+NX_Q8NB91	Fanconi anemia group B protein	859	97726	7.79	0	Nucleus	Fanconi anemia complementation group B	DNA repair protein required for FANCD2 ubiquitination.	NA	NA	Fanconi anemia pathway;Fanconi Anemia Pathway	PE1	X
+NX_Q8NBA8	DTW domain-containing protein 2	298	33416	8.95	0	Nucleus	NA	NA	NA	Belongs to the DTW family.	NA	PE1	5
+NX_Q8NBB2	Putative uncharacterized protein ST20-AS1	130	13907	11.83	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_Q8NBB4	Zinc finger and SCAN domain-containing protein 1	408	45286	8.85	0	Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	19
+NX_Q8NBC4	Uncharacterized protein C20orf203	194	21159	11.74	0	Cytoplasm	NA	NA	NA	NA	NA	PE2	20
+NX_Q8NBD8	Transmembrane protein 229B	167	19531	5.68	4	Membrane	NA	NA	NA	Belongs to the TMEM229 family.	NA	PE2	14
+NX_Q8NBE8	Kelch-like protein 23	558	63923	5.4	0	Nucleoplasm;Cytoskeleton	NA	NA	NA	NA	NA	PE1	2
+NX_Q8NBF1	Zinc finger protein GLIS1	620	65976	7.56	0	Nucleus	NA	Acts as both a repressor and activator of transcription (PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (By similarity).	NA	Belongs to the GLI C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_Q8NBF2	NHL repeat-containing protein 2	726	79444	5.33	0	Nucleoplasm;Cytosol	Fibrosis, neurodegeneration, and cerebral angiomatosis	Required for normal embryonic development.	NA	NA	Platelet degranulation	PE1	10
+NX_Q8NBF4	Putative uncharacterized protein FLJ33307	154	16182	11.26	0	NA	NA	NA	NA	NA	NA	PE5	7
+NX_Q8NBF6	Late secretory pathway protein AVL9 homolog	648	71947	5.79	1	Membrane;Recycling endosome;Endoplasmic reticulum	NA	Functions in cell migration.	NA	Belongs to the AVL9 family.	NA	PE1	7
+NX_Q8NBH2	Kyphoscoliosis peptidase	561	63855	7.1	0	Nucleoplasm;Z line;Cytoskeleton	Myopathy, myofibrillar, 7	Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity).	NA	Belongs to the transglutaminase-like superfamily.	NA	PE1	3
+NX_Q8NBI2	Cytochrome b ascorbate-dependent protein 3	242	27214	9.64	6	Lysosome membrane;Nucleolus;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Late endosome membrane	NA	Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity).	N-glycosylated.	NA	NA	PE1	11
+NX_Q8NBI3	Draxin	349	38650	7.62	0	Secreted	NA	Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.	NA	Belongs to the draxin family.	NA	PE1	1
+NX_Q8NBI5	Solute carrier family 43 member 3	491	54529	8.81	12	Membrane;Cytoplasmic vesicle;Nucleoplasm;Cell membrane	NA	Putative transporter.	NA	Belongs to the SLC43A transporter (TC 2.A.1.44) family.	NA	PE1	11
+NX_Q8NBI6	Xyloside xylosyltransferase 1	393	43807	8.35	1	Endoplasmic reticulum membrane	NA	Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869).	NA	Belongs to the glycosyltransferase 8 family.	NA	PE1	3
+NX_Q8NBJ4	Golgi membrane protein 1	401	45333	4.91	1	Golgi apparatus;cis-Golgi network membrane	NA	Unknown. Cellular response protein to viral infection.	Phosphorylation sites are present in the extracellular medium.;Glycosylated.	Belongs to the GOLM1/CASC4 family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	9
+NX_Q8NBJ5	Procollagen galactosyltransferase 1	622	71636	6.85	0	Cytoplasmic vesicle;Endoplasmic reticulum lumen	Brain small vessel disease 3	Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen (PubMed:19075007, PubMed:22216269, PubMed:27402836). By acting on collagen glycosylation, facilitates the formation of collagen triple helix (PubMed:27402836). Also involved in the biosynthesis of collagen type IV (PubMed:30412317).	N-glycosylated.	Belongs to the glycosyltransferase 25 family.	Lysine degradation;Other types of O-glycan biosynthesis;Collagen biosynthesis and modifying enzymes	PE1	19
+NX_Q8NBJ7	Inactive C-alpha-formylglycine-generating enzyme 2	301	33843	7.78	0	Cytoplasmic vesicle;Endoplasmic reticulum lumen;Cell membrane	NA	Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.	NA	Belongs to the sulfatase-modifying factor family.	Glycosphingolipid metabolism;The activation of arylsulfatases	PE1	7
+NX_Q8NBJ9	SID1 transmembrane family member 2	832	94454	6.55	10	Lysosome membrane;Cell membrane	NA	Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity).	Glycosylated.	Belongs to the SID1 family.	NA	PE1	11
+NX_Q8NBK3	Formylglycine-generating enzyme	374	40556	6.18	0	Endoplasmic reticulum lumen	Multiple sulfatase deficiency	Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:25931126, PubMed:16368756, PubMed:21224894). 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:25931126, PubMed:16368756). Known substrates include GALNS, ARSA, STS and ARSE (PubMed:12757706, PubMed:15907468, PubMed:15657036).	N-glycosylated. Contains high-mannose-type oligosaccharides.	Belongs to the sulfatase-modifying factor family.	Protein modification; sulfatase oxidation.;Lysosome;Glycosphingolipid metabolism;The activation of arylsulfatases	PE1	3
+NX_Q8NBL1	Protein O-glucosyltransferase 1	392	46189	8.91	0	Endoplasmic reticulum;Cytosol;Endoplasmic reticulum lumen	Dowling-Degos disease 4;Muscular dystrophy, limb-girdle, autosomal recessive 21	Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PubMed:27807076). Notch glucosylation does not affect Notch ligand binding (PubMed:21490058). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity).	NA	Belongs to the glycosyltransferase 90 family.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;Pre-NOTCH Processing in the Endoplasmic Reticulum	PE1	3
+NX_Q8NBL3	Transmembrane protein 178A	297	33019	8.83	3	Nucleoplasm;Endoplasmic reticulum membrane;Cytoplasmic vesicle	NA	Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1.	NA	Belongs to the TMEM178 family.	NA	PE1	2
+NX_Q8NBM4	Ubiquitin-associated domain-containing protein 2	344	38964	9.21	3	Cytosol;Endoplasmic reticulum membrane	NA	Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (PubMed:23297223). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040).	NA	NA	NA	PE1	13
+NX_Q8NBM8	Prenylcysteine oxidase-like	494	54646	6.81	0	Nucleoplasm;Mitochondrion;Secreted	NA	Probable oxidoreductase.	NA	Belongs to the prenylcysteine oxidase family.	Platelet degranulation	PE1	5
+NX_Q8NBN3	Transmembrane protein 87A	555	63430	6.32	7	Golgi apparatus;Golgi apparatus membrane	NA	May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).	NA	Belongs to the LU7TM family. TMEM87 subfamily.	NA	PE1	15
+NX_Q8NBN7	Retinol dehydrogenase 13	331	35932	8.23	0	Cytosol;Mitochondrion inner membrane;Mitochondrion	NA	Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency (PubMed:18039331). Has no activity toward steroids (PubMed:18039331).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Cofactor metabolism; retinol metabolism.;RA biosynthesis pathway	PE1	19
+NX_Q8NBP0	Tetratricopeptide repeat protein 13	860	96813	6.56	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_Q8NBP5	Major facilitator superfamily domain-containing protein 9	474	50619	9.28	9	Membrane;Nucleolus	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE1	2
+NX_Q8NBP7	Proprotein convertase subtilisin/kexin type 9	692	74286	6.14	0	Golgi apparatus;Cytoplasm;Secreted;Cell surface;Endoplasmic reticulum;Endosome;Lysosome	Hypercholesterolemia, autosomal dominant, 3	Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, PubMed:17461796, PubMed:18197702, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.	Phosphorylation protects the propeptide against proteolysis.;Cleavage by furin and PCSK5 generates a truncated inactive protein that is unable to induce LDLR degradation.;Undergoes autocatalytic cleavage in the endoplasmic reticulum to release the propeptide from the N-terminus and the cleavage of the propeptide is strictly required for its maturation and activation. The cleaved propeptide however remains associated with the catalytic domain through non-covalent interactions, preventing potential substrates from accessing its active site. As a result, it is secreted from cells as a propeptide-containing, enzymatically inactive protein.	Belongs to the peptidase S8 family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);VLDLR internalisation and degradation;Post-translational protein phosphorylation;LDL clearance	PE1	1
+NX_Q8NBQ5	Estradiol 17-beta-dehydrogenase 11	300	32936	9.2	0	Endoplasmic reticulum;Lipid droplet	NA	Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.	Estrogen biosynthesis	PE1	4
+NX_Q8NBQ7	Aquaporin-11	271	30203	8.08	6	Cytoplasmic vesicle membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.	Passive transport by Aquaporins	PE1	11
+NX_Q8NBR0	Tumor protein p53-inducible protein 13	393	42238	10.97	1	Cytoplasm;Cell membrane	NA	May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed.	NA	NA	NA	PE1	17
+NX_Q8NBR6	Ubiquitin carboxyl-terminal hydrolase MINDY-2	621	67106	4.44	0	Nucleoplasm	NA	Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798).	NA	Belongs to the MINDY deubiquitinase family. FAM63 subfamily.	NA	PE1	15
+NX_Q8NBR9	Uncharacterized protein C11orf72	251	27887	9.56	0	NA	NA	NA	NA	NA	NA	PE2	11
+NX_Q8NBS3	Sodium bicarbonate transporter-like protein 11	891	99581	7.59	11	Membrane;Cytoplasmic vesicle;Nucleoplasm;Cell membrane	Corneal dystrophy and perceptive deafness;Corneal endothelial dystrophy;Corneal dystrophy, Fuchs endothelial, 4	Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.	Glycosylated.	Belongs to the anion exchanger (TC 2.A.31) family.	NA	PE1	20
+NX_Q8NBS9	Thioredoxin domain-containing protein 5	432	47629	5.63	0	Endoplasmic reticulum;Endoplasmic reticulum lumen	NA	Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).	NA	Belongs to the protein disulfide isomerase family.	Protein processing in endoplasmic reticulum;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Neutrophil degranulation	PE1	6
+NX_Q8NBT0	POC1 centriolar protein homolog A	407	45009	7.31	0	Spindle pole;Centrosome;Cilium basal body;Centriole	Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis	Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.	NA	Belongs to the WD repeat POC1 family.	NA	PE1	3
+NX_Q8NBT2	Kinetochore protein Spc24	197	22478	4.65	0	Kinetochore;Nucleoplasm;Nucleus;Nucleolus	NA	Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).	NA	Belongs to the SPC24 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	19
+NX_Q8NBT3	Transmembrane protein 145	493	55534	8.88	8	Membrane;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	19
+NX_Q8NBU5	ATPase family AAA domain-containing protein 1	361	40744	6.43	0	Cytoplasm;Mitochondrion;Postsynaptic cell membrane;Nucleolus;Peroxisome	Hyperekplexia 4	ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).	NA	Belongs to the AAA ATPase family.	Class I peroxisomal membrane protein import	PE1	10
+NX_Q8NBV4	Inactive phospholipid phosphatase 7	271	29448	9.98	4	Endoplasmic reticulum membrane;Membrane;Nucleoplasm;Nucleus envelope;Cytoplasmic vesicle	NA	Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).	NA	Belongs to the PA-phosphatase related phosphoesterase family.	NA	PE1	9
+NX_Q8NBV8	Synaptotagmin-8	401	44138	9.65	1	Cell membrane;Acrosome	NA	May play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity).	NA	Belongs to the synaptotagmin family.	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	11
+NX_Q8NBW4	Sodium-coupled neutral amino acid transporter 9	561	63776	7.59	11	Cytoplasmic vesicle;Lysosome membrane;Late endosome membrane	NA	Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906, PubMed:29053970). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids (PubMed:25561175, PubMed:25567906). Acts as an arginine sensor (PubMed:25567906, PubMed:29053970). Following activation by arginine binding, mediates transport of leucine, tyrosine and phenylalanine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation (PubMed:29053970).	Glycosylated.	Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.	Macroautophagy;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;mTOR signalling;mTORC1-mediated signalling;Regulation of PTEN gene transcription	PE1	5
+NX_Q8NBX0	Saccharopine dehydrogenase-like oxidoreductase	429	47151	9.24	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the saccharopine dehydrogenase family.	Platelet degranulation	PE1	1
+NX_Q8NBZ0	INO80 complex subunit E	244	26478	8.41	0	Nucleoplasm;Nucleolus;Nucleus	NA	Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	NA	NA	DNA Damage Recognition in GG-NER;UCH proteinases	PE1	16
+NX_Q8NBZ7	UDP-glucuronic acid decarboxylase 1	420	47577	8.99	1	Golgi stack membrane	NA	Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.	NA	Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.	Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways	PE1	2
+NX_Q8NBZ9	Putative uncharacterized protein NEXN-AS1	246	25156	10.69	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q8NC01	C-type lectin domain family 1 member A	280	31952	5.93	1	Membrane	NA	NA	NA	NA	NA	PE1	12
+NX_Q8NC06	Acyl-CoA-binding domain-containing protein 4	268	30308	6.83	0	Nucleoplasm;Cytoplasmic vesicle	NA	Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.	NA	NA	Peroxisomal lipid metabolism	PE1	17
+NX_Q8NC24	RELT-like protein 2	303	32405	6.42	1	Cytoplasmic vesicle;Cell membrane	NA	Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290).	Phosphorylated in vitro by OXSR1.	Belongs to the RELT family.	NA	PE1	5
+NX_Q8NC26	Zinc finger protein 114	417	47747	8.9	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8NC38	Putative uncharacterized protein ZNF436-AS1	126	14381	9.35	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q8NC42	E3 ubiquitin-protein ligase RNF149	400	43165	6.08	1	Membrane;Cytoplasmic vesicle;Cell membrane	NA	E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.	NA	NA	Protein modification; protein ubiquitination.	PE1	2
+NX_Q8NC44	Reticulophagy regulator 2	543	57830	4.39	3	Membrane;Cytosol	NA	NA	NA	Belongs to the RETREG family.	NA	PE1	2
+NX_Q8NC51	Plasminogen activator inhibitor 1 RNA-binding protein	408	44965	8.66	0	Cytoplasm;Cytosol;Perinuclear region;Nucleus	NA	May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).	NA	NA	NA	PE1	1
+NX_Q8NC54	Keratinocyte-associated transmembrane protein 2	265	29235	4.93	1	Membrane;Golgi apparatus	NA	NA	NA	NA	NA	PE1	5
+NX_Q8NC56	LEM domain-containing protein 2	503	56975	9.16	2	Nucleus inner membrane;Nucleus membrane	Cataract 46, juvenile-onset	Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT. Required for myoblast differentiation involving regulation of ERK signaling (By similarity).;Involved in nuclear structure organization (PubMed:16339967). Required for maintaining the integrity of the nuclear envelope (PubMed:17097643).	NA	NA	Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina;Nuclear Envelope Breakdown	PE1	6
+NX_Q8NC60	Nitric oxide-associated protein 1	698	78458	8.87	0	Mitochondrion inner membrane;Mitochondrion	NA	Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.	NA	Belongs to the TRAFAC class YlqF/YawG GTPase family. NOA1 subfamily.	NA	PE1	4
+NX_Q8NC67	Neuropilin and tolloid-like protein 2	525	59393	6.38	1	Membrane;Golgi apparatus	NA	Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).	N-glycosylated.	NA	NA	PE1	16
+NX_Q8NC69	BTB/POZ domain-containing protein KCTD6	237	27610	5.61	0	Nucleolus;Mitochondrion;M line	NA	Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation;RUNX1 regulates estrogen receptor mediated transcription;Estrogen-dependent gene expression	PE1	3
+NX_Q8NC74	RBBP8 N-terminal-like protein	664	71432	6.08	0	NA	NA	NA	NA	NA	NA	PE1	20
+NX_Q8NC96	Adaptin ear-binding coat-associated protein 1	275	29737	6.33	0	Cytoplasmic vesicle;Cytosol;Clathrin-coated vesicle membrane;Cell membrane	Epileptic encephalopathy, early infantile, 21	Involved in endocytosis.	NA	Belongs to the NECAP family.	Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	12
+NX_Q8NCA5	Protein FAM98A	518	55273	9.1	0	Cytoplasmic vesicle	NA	Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy (PubMed:28040436).	NA	Belongs to the FAM98 family.	NA	PE1	2
+NX_Q8NCA9	Zinc finger protein 784	323	34237	7.95	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8NCB2	CaM kinase-like vesicle-associated protein	501	54354	5.38	0	Cytoplasm;Cell membrane;Cytoplasmic vesicle membrane;Nucleoplasm;Nucleus;Cytoskeleton	NA	Does not appear to have detectable kinase activity.	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	3
+NX_Q8NCC3	Group XV phospholipase A2	412	46658	6.26	0	Mitochondrion;Secreted;Membrane;Nucleoplasm;Lysosome;Cytoplasmic vesicle	NA	Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508).	N-glycosylated (PubMed:11790796, PubMed:23958596). N-glycosylation is important for maturation of the enzyme and normal subcellular location (PubMed:23958596).	Belongs to the AB hydrolase superfamily. Lipase family.	Glycerophospholipid metabolism;Lysosome;Hydrolysis of LPC	PE1	16
+NX_Q8NCC5	Sugar phosphate exchanger 3	494	54486	5.46	12	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	NA	NA	Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.	NA	PE1	7
+NX_Q8NCD3	Holliday junction recognition protein	748	83539	9.4	0	Nucleoplasm;Centromere;Mitochondrion;Nucleolus	NA	Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.	NA	NA	Deposition of new CENPA-containing nucleosomes at the centromere	PE1	2
+NX_Q8NCE0	tRNA-splicing endonuclease subunit Sen2	465	53247	7.95	0	Nucleolus;Nucleoplasm;Centrosome;Cytosol;Nucleus	Pontocerebellar hypoplasia 2B	Is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.;Probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.;Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.	NA	Belongs to the tRNA-intron endonuclease family.	tRNA processing in the nucleus	PE1	3
+NX_Q8NCE2	Myotubularin-related protein 14	650	72203	5.85	0	Cytoplasm	Myopathy, centronuclear, 1	Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Macroautophagy;Synthesis of PIPs at the plasma membrane	PE1	3
+NX_Q8NCF0	C-type lectin domain family 18 member C	446	49585	8.54	0	Golgi apparatus;Endoplasmic reticulum;Endosome;Secreted	NA	Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.	NA	NA	NA	PE2	16
+NX_Q8NCF5	NFATC2-interacting protein	419	45817	6.19	0	Nucleoplasm;Cytoplasm;Nucleus	NA	In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).	Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.	NA	NA	PE1	16
+NX_Q8NCG5	Carbohydrate sulfotransferase 4	386	45134	9.11	1	Golgi apparatus membrane	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location.	NA	Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.	Glycosaminoglycan biosynthesis - keratan sulfate;O-linked glycosylation of mucins	PE1	16
+NX_Q8NCG7	Sn1-specific diacylglycerol lipase beta	672	73732	6.09	4	Nucleoplasm;Cell membrane	NA	Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Arachidonate production from DAG	PE1	7
+NX_Q8NCH0	Carbohydrate sulfotransferase 14	376	42997	9.55	1	Cytoplasmic vesicle;Golgi apparatus membrane	Ehlers-Danlos syndrome, musculocontractural type 1	Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.	NA	Belongs to the sulfotransferase 2 family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Dermatan sulfate biosynthesis;Defective CHST14 causes EDS, musculocontractural type	PE1	15
+NX_Q8NCI6	Beta-galactosidase-1-like protein 3	653	74823	9.05	0	NA	NA	NA	NA	Belongs to the glycosyl hydrolase 35 family.	NA	PE1	11
+NX_Q8NCJ5	SPRY domain-containing protein 3	442	49694	5.78	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	NA	NA	NA	NA	PE1	12
+NX_Q8NCK3	Zinc finger protein 485	441	50280	9.68	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	10
+NX_Q8NCK7	Monocarboxylate transporter 11	471	47791	8.67	12	Endoplasmic reticulum membrane;Cell membrane	Diabetes mellitus, non-insulin-dependent	Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345).	NA	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	NA	PE1	17
+NX_Q8NCL4	Polypeptide N-acetylgalactosaminyltransferase 6	622	71159	8.47	1	Golgi apparatus;Nucleoplasm;Golgi apparatus membrane	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	12
+NX_Q8NCL8	Transmembrane protein 116	245	27464	9.13	4	Membrane;Nucleoplasm;Cytoskeleton	NA	NA	NA	NA	NA	PE2	12
+NX_Q8NCL9	Protein APCDD1-like	501	55635	9.15	1	Membrane;Mitochondrion	NA	NA	NA	NA	NA	PE1	20
+NX_Q8NCM2	Potassium voltage-gated channel subfamily H member 5	988	111877	7.51	6	Membrane;Nucleoplasm;Cytosol;Centrosome	NA	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.	NA	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily.	Voltage gated Potassium channels	PE1	14
+NX_Q8NCM8	Cytoplasmic dynein 2 heavy chain 1	4307	492622	6.13	0	Cytoplasm;Mitochondrion;Cilium axoneme;Cell membrane	Short-rib thoracic dysplasia 3 with or without polydactyly	May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity).	NA	Belongs to the dynein heavy chain family.	Phagosome;Vasopressin-regulated water reabsorption;Salmonella infection;Intraflagellar transport;Hedgehog 'off' state	PE1	11
+NX_Q8NCN2	Zinc finger and BTB domain-containing protein 34	500	55534	6	0	Nucleoplasm;Nucleus	NA	May be a transcriptional repressor.	NA	NA	NA	PE1	9
+NX_Q8NCN4	E3 ubiquitin-protein ligase RNF169	708	77194	9.28	0	Nucleoplasm;Cytosol;Nucleus	NA	Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.	NA	Belongs to the RNF169 family.	Protein modification; protein ubiquitination.	PE1	11
+NX_Q8NCN5	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial	879	99364	5.93	0	Mitochondrion matrix;Mitochondrion	NA	Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine.	NA	Belongs to the GcvT family.	Regulation of pyruvate dehydrogenase (PDH) complex	PE1	16
+NX_Q8NCP5	Zinc finger and BTB domain-containing protein 44	570	63848	6.16	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	11
+NX_Q8NCQ2	Uncharacterized protein CSNK1G2-AS1	148	16070	11.82	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_Q8NCQ3	Putative uncharacterized protein encoded by LINC00301	95	11012	8.74	1	Membrane	NA	NA	NA	NA	NA	PE5	11
+NX_Q8NCQ5	F-box only protein 15	510	57258	8.88	0	NA	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	18
+NX_Q8NCQ7	Protein PROCA1	364	40506	7.94	0	NA	NA	NA	NA	Belongs to the PROCA1 family.	NA	PE1	17
+NX_Q8NCR0	UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2	500	56704	5.46	1	Endoplasmic reticulum;Nucleoplasm;Golgi apparatus;Golgi apparatus membrane	Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A11	Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.	N-glycosylated.	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;O-linked glycosylation	PE1	1
+NX_Q8NCR3	Uncharacterized protein C11orf65	313	36720	7.22	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_Q8NCR6	Spermatid-specific manchette-related protein 1	262	30167	8.76	0	Cytoplasm;Nucleus;Cytoskeleton	NA	May play a role in spermatogenesis (By similarity). May be involved in differentiation or function of ciliated cells.	NA	Belongs to the SMRP1 family.	NA	PE1	9
+NX_Q8NCR9	Clarin-3	226	25321	9.3	4	Membrane	NA	NA	NA	Belongs to the clarin family.	NA	PE1	10
+NX_Q8NCS4	Transmembrane protein 35B	154	16885	9.26	3	Membrane;Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the DoxX family.	NA	PE1	1
+NX_Q8NCS7	Choline transporter-like protein 5	719	81694	8.47	10	Membrane;Cytosol	NA	NA	NA	Belongs to the CTL (choline transporter-like) family.	Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds	PE1	1
+NX_Q8NCT1	Arrestin domain-containing protein 4	418	45479	5.84	0	Cytoplasmic vesicle;Early endosome;Cell membrane	NA	Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake (PubMed:19605364).	NA	Belongs to the arrestin family.	NA	PE1	15
+NX_Q8NCT3	Uncharacterized protein KIAA0895	520	60525	10.03	0	Nucleoplasm;Cytosol;Cell junction;Cell membrane	NA	NA	NA	NA	NA	PE1	7
+NX_Q8NCU1	Uncharacterized protein CCDC197	143	16081	6.11	0	NA	NA	NA	NA	NA	NA	PE1	14
+NX_Q8NCU4	Coiled-coil domain-containing protein 191	936	110568	9.61	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	3
+NX_Q8NCU7	C2 calcium-dependent domain-containing protein 4A	369	39744	11.28	0	Nucleus	NA	May be involved in inflammatory process. May regulate cell architecture and adhesion.	NA	Belongs to the C2CD4 family.	NA	PE1	15
+NX_Q8NCU8	Mitoregulin	56	6527	11.27	1	Mitochondrion inner membrane	NA	Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species (PubMed:29949756). Also increases mitochondrial calcium retention capacity (PubMed:29949756).	NA	Belongs to the mitoregulin family.	NA	PE1	2
+NX_Q8NCV1	Adenosine deaminase domain-containing protein 2	583	61755	9.11	0	NA	NA	NA	NA	Belongs to the ADAD family.	NA	PE1	16
+NX_Q8NCW0	Kremen protein 2	462	48849	7.44	1	Membrane;Nucleolus	NA	Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation.	NA	NA	TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	PE1	16
+NX_Q8NCW5	NAD(P)H-hydrate epimerase	288	31675	7.56	0	Nucleoplasm;Cytosol;Mitochondrion;Secreted	Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.	Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.	Belongs to the NnrE/AIBP family.	Nicotinamide salvaging	PE1	1
+NX_Q8NCW6	Polypeptide N-acetylgalactosaminyltransferase 11	608	68919	8.47	1	Golgi apparatus membrane	NA	Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	7
+NX_Q8NCX0	Coiled-coil domain-containing protein 150	1101	128761	6.58	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	2
+NX_Q8NCY6	Myb/SANT-like DNA-binding domain-containing protein 4	345	41150	5.37	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	11
+NX_Q8ND04	Protein SMG8	991	109684	7.74	0	Nucleoplasm	NA	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.	Phosphorylated by SMG1.	Belongs to the SMG8 family.	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PE1	17
+NX_Q8ND07	Basal body-orientation factor 1	529	61987	9.07	0	Nucleoplasm;Centriolar satellite;Cilium basal body;Cell membrane	NA	Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity).	NA	Belongs to the BBOF1 family.	NA	PE1	14
+NX_Q8ND23	Capping protein, Arp2/3 and myosin-I linker protein 3	1372	150230	7.2	0	Cytoplasm;Cell membrane	NA	NA	NA	Belongs to the CARMIL family.	NA	PE1	14
+NX_Q8ND24	RING finger protein 214	703	77667	6.51	0	Golgi apparatus;Cytosol	NA	NA	NA	NA	NA	PE1	11
+NX_Q8ND25	E3 ubiquitin-protein ligase ZNRF1	227	23783	6.18	0	Golgi apparatus;Cell membrane;Membrane;Endosome;Synaptic vesicle membrane;Lysosome	NA	E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	16
+NX_Q8ND30	Liprin-beta-2	876	98544	5.88	0	Mitochondrion	NA	May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.	NA	Belongs to the liprin family. Liprin-beta subfamily.	Receptor-type tyrosine-protein phosphatases	PE1	11
+NX_Q8ND56	Protein LSM14 homolog A	463	50530	9.55	0	Cytosol;P-body;Stress granule	NA	Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.	NA	Belongs to the LSM14 family.	NA	PE1	19
+NX_Q8ND61	Uncharacterized protein C3orf20	904	101266	9.24	1	Membrane;Cytoplasm;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	3
+NX_Q8ND71	GTPase IMAP family member 8	665	74890	8.62	0	Golgi apparatus;Endoplasmic reticulum;Cytosol;Mitochondrion	NA	Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.	NA	PE1	7
+NX_Q8ND76	Cyclin-Y	341	39337	6.76	0	Nucleus;Cell membrane	NA	Might play a role in the activation of MYC-mediated transcription.;Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane.	Ubiquitinated; leading to its degradation.;Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination.	Belongs to the cyclin family. Cyclin Y subfamily.	NA	PE1	10
+NX_Q8ND82	Zinc finger protein 280C	737	83096	9.29	0	Nucleoplasm;Nucleus;Nucleolus	NA	May function as a transcription factor.	NA	NA	NA	PE1	X
+NX_Q8ND83	SLAIN motif-containing protein 1	568	60595	7.57	0	Cytoskeleton	NA	Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation.	NA	Belongs to the SLAIN motif-containing family.	NA	PE1	13
+NX_Q8ND90	Paraneoplastic antigen Ma1	353	39761	4.78	0	Nucleolus	NA	NA	NA	Belongs to the PNMA family.	NA	PE1	14
+NX_Q8ND94	LRRN4 C-terminal-like protein	238	25262	6.07	1	Membrane;Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	11
+NX_Q8NDA2	Hemicentin-2	5059	541978	5.57	0	Cytoplasmic vesicle;Extracellular matrix;Cleavage furrow	NA	NA	NA	NA	NA	PE1	9
+NX_Q8NDA8	Maestro heat-like repeat-containing protein family member 1	1641	181249	6.44	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	8
+NX_Q8NDB2	B-cell scaffold protein with ankyrin repeats	785	89282	5.28	0	Nucleoplasm;Cytosol;Cell membrane	Systemic lupus erythematosus	Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.	Phosphorylated on tyrosines upon BCR activation.	NA	NA	PE1	4
+NX_Q8NDB6	Protein FAM156A/FAM156B	213	24412	9.75	1	Membrane;Nucleus envelope	NA	NA	NA	NA	NA	PE1	X
+NX_Q8NDC0	MAPK-interacting and spindle-stabilizing protein-like	245	24269	5.3	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the MISS family.	NA	PE1	14
+NX_Q8NDC4	MORN repeat-containing protein 4	146	16236	7.88	0	Stereocilium;Cytoplasm;Filopodium tip;Nucleus	NA	Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.	NA	NA	NA	PE1	10
+NX_Q8NDD1	Uncharacterized protein C1orf131	293	32610	9.88	0	Chromosome	NA	NA	NA	NA	NA	PE1	1
+NX_Q8NDF8	Terminal nucleotidyltransferase 4B	572	63267	9.07	0	Cytoplasm;Nucleolus;Nucleus	NA	Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037).	NA	Belongs to the DNA polymerase type-B-like family.	NA	PE1	16
+NX_Q8NDG6	ATP-dependent RNA helicase TDRD9	1382	155683	6.62	0	Cytoplasm;Nucleus	Spermatogenic failure 30	ATP-binding RNA helicase required during spermatogenesis (PubMed:28536242). Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4.	NA	Belongs to the DEAD box helicase family. DEAH subfamily.	PIWI-interacting RNA (piRNA) biogenesis	PE1	14
+NX_Q8NDH2	Coiled-coil domain-containing protein 168	2452	277951	9.35	0	NA	NA	NA	NA	NA	NA	PE1	13
+NX_Q8NDH3	Probable aminopeptidase NPEPL1	523	55861	6.41	0	Nucleoplasm	NA	Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.	NA	Belongs to the peptidase M17 family.	NA	PE1	20
+NX_Q8NDH6	Islet cell autoantigen 1-like protein	482	54407	5.18	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	2
+NX_Q8NDI1	EH domain-binding protein 1	1231	140017	5.24	0	Cytoplasm;Cell membrane;Membrane;Endosome;Cytosol	Prostate cancer, hereditary, 12	May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity).	Prenylated (Probable). Farnelysation (predominant) and geranylgeranylation has been observed in vitro.	NA	NA	PE1	2
+NX_Q8NDL9	Cytosolic carboxypeptidase-like protein 5	886	97534	9.34	0	Cytoplasm;Nucleus;Cytosol;Spindle;Midbody;Cytoskeleton	Retinitis pigmentosa 75	Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS.	NA	Belongs to the peptidase M14 family.	Carboxyterminal post-translational modifications of tubulin	PE1	2
+NX_Q8NDM7	Cilia- and flagella-associated protein 43	1665	191984	5.71	0	Flagellum;Cytoplasm;Flagellum axoneme	Spermatogenic failure 19	Flagellar protein involved in sperm flagellum axoneme organization and function.	NA	Belongs to the CFAP43 family.	NA	PE1	10
+NX_Q8NDN9	RCC1 and BTB domain-containing protein 1	531	58252	6.02	0	Cytoplasm;Nucleoplasm;Nucleus	Retinal dystrophy with or without extraocular anomalies	May be involved in cell cycle regulation by chromatin remodeling.	NA	NA	NA	PE1	13
+NX_Q8NDP4	Zinc finger protein 439	499	58395	9.4	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8NDQ6	Zinc finger protein 540	660	77094	9.58	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	May act as a transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8NDT2	Putative RNA-binding protein 15B	890	97205	9.86	0	Nucleoplasm;Nucleus speckle;Nucleus envelope	NA	RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903).	NA	Belongs to the RRM Spen family.	NA	PE1	3
+NX_Q8NDV1	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	305	35395	9.23	1	Nucleoplasm;Golgi apparatus membrane	NA	Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity).	NA	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Sialic acid metabolism;Termination of O-glycan biosynthesis	PE1	1
+NX_Q8NDV2	G-protein coupled receptor 26	337	37604	9.82	7	Cell membrane	NA	Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	10
+NX_Q8NDV3	Structural maintenance of chromosomes protein 1B	1235	143908	7.69	0	Chromosome;Nucleoplasm;Centromere;Cytosol;Nucleus	NA	Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).	NA	Belongs to the SMC family. SMC1 subfamily.	Cell cycle;Oocyte meiosis;Meiotic synapsis	PE1	22
+NX_Q8NDV7	Trinucleotide repeat-containing gene 6A protein	1962	210297	6.55	0	Golgi apparatus;Nucleoplasm;P-body;Cytoplasmic vesicle	Epilepsy, familial adult myoclonic, 6	Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.	NA	Belongs to the GW182 family.	MAPK6/MAPK4 signaling;Transcriptional regulation by small RNAs;Oxidative Stress Induced Senescence;Pre-NOTCH Transcription and Translation;TP53 Regulates Metabolic Genes;Ca2+ pathway;Post-transcriptional silencing by small RNAs;Oncogene Induced Senescence;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of RUNX1 Expression and Activity;Regulation of PTEN mRNA translation;Competing endogenous RNAs (ceRNAs) regulate PTEN translation;Estrogen-dependent gene expression;Transcriptional Regulation by MECP2;Regulation of MECP2 expression and activity	PE1	16
+NX_Q8NDW4	Zinc finger protein 248	579	67087	8.59	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	10
+NX_Q8NDW8	Tetratricopeptide repeat protein 21A	1320	150944	6.85	0	Nucleoplasm	Spermatogenic failure 37	Intraflagellar transport (IFT)-associated protein required for spermatogenesis (PubMed:30929735). Required for sperm flagellar formation and intraflagellar transport (PubMed:30929735).	NA	Belongs to the TTC21 family.	NA	PE1	3
+NX_Q8NDX1	PH and SEC7 domain-containing protein 4	1056	116249	5.31	0	Ruffle membrane;Cell membrane	NA	Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.	NA	NA	Endocytosis	PE1	2
+NX_Q8NDX2	Vesicular glutamate transporter 3	589	64991	5.95	12	Membrane;Synaptic vesicle membrane;Synaptosome	Deafness, autosomal dominant, 25	Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.	NA	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.	Synaptic vesicle cycle;Glutamatergic synapse;Organic anion transporters;Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)	PE1	12
+NX_Q8NDX5	Polyhomeotic-like protein 3	983	106162	6.15	0	Nucleoplasm;Nucleus	NA	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.	NA	NA	SUMOylation of DNA damage response and repair proteins;Oxidative Stress Induced Senescence;SUMOylation of RNA binding proteins;SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins	PE1	3
+NX_Q8NDX6	Zinc finger protein 740	193	21857	9.38	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	12
+NX_Q8NDX9	Lymphocyte antigen 6 complex locus protein G5b	201	22572	6.17	0	Secreted	NA	NA	N-glycosylated.	NA	NA	PE1	6
+NX_Q8NDY3	[Protein ADP-ribosylarginine] hydrolase-like protein 1	354	40105	5.58	0	Nucleoplasm	NA	NA	NA	Belongs to the ADP-ribosylglycohydrolase family.	NA	PE1	13
+NX_Q8NDY4	Myelodysplastic syndrome 2 translocation-associated protein	140	15384	8.83	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q8NDY6	Class E basic helix-loop-helix protein 23	225	23665	9.37	0	Nucleus	NA	May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity).	NA	NA	NA	PE1	20
+NX_Q8NDY8	Transmembrane protein 52	209	22122	5.53	1	Membrane	NA	NA	NA	NA	NA	PE2	1
+NX_Q8NDZ0	BEN domain-containing protein 2	799	87919	5.23	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_Q8NDZ2	SUMO-interacting motif-containing protein 1	872	96838	6.1	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	5
+NX_Q8NDZ4	Divergent protein kinase domain 2A	430	49482	8.84	0	Golgi apparatus;COPI-coated vesicle;Secreted	NA	May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade.	NA	Belongs to the DIPK family.	NA	PE1	3
+NX_Q8NDZ6	Transmembrane protein 161B	487	55482	8.59	8	Membrane	NA	NA	NA	Belongs to the TMEM161 family.	NA	PE1	5
+NX_Q8NE00	Transmembrane protein 104	496	55679	6.79	11	Membrane;Nucleoplasm;Golgi apparatus	NA	NA	NA	Belongs to the TMEM104 family.	NA	PE1	17
+NX_Q8NE01	Metal transporter CNNM3	707	76119	5.76	4	Cytosol;Cell membrane	NA	Probable metal transporter.	NA	Belongs to the ACDP family.	NA	PE1	2
+NX_Q8NE09	Regulator of G-protein signaling 22	1264	147163	8.08	0	Cytoplasm;Nucleus	NA	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.	NA	NA	G alpha (i) signalling events	PE1	8
+NX_Q8NE18	Putative methyltransferase NSUN7	718	81039	8.95	0	Cytoplasmic vesicle	NA	May have S-adenosyl-L-methionine-dependent methyl-transferase activity.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	NA	PE1	4
+NX_Q8NE22	SET domain-containing protein 9	299	34095	8.93	0	Nucleoplasm	NA	NA	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	Regulation of TP53 Activity through Methylation	PE1	5
+NX_Q8NE28	Serine/threonine kinase-like domain-containing protein STKLD1	680	75677	5.17	0	NA	NA	NA	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.	NA	PE1	9
+NX_Q8NE31	Protein FAM13C	585	65727	5.5	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the FAM13 family.	NA	PE1	10
+NX_Q8NE35	Cytoplasmic polyadenylation element-binding protein 3	698	76014	6.56	0	Cytoplasm;Postsynaptic density;Synapse;Dendrite;Nucleus	NA	Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195).	Activated by NEURL1-mediated monoubiquitination, resulting in the growth of new dendritic spines and increased levels of GRIA1 and GRIA2. NEURL1-mediated monoubiquitination facilitates synaptic plasticity and hippocampal-dependent memory storage.;Following neuronal stimulation, cleaved by CAPN2 which abolishes its translational repressor activity, leading to translation of CPEB3 target mRNAs.;Phosphorylation is enhanced by neuronal stimulation.;Under basal unstimulated conditions when CPEB3 is mainly unaggregated, sumoylated and acts as a translational repressor. Following neuronal stimulation, becomes desumoylated and aggregated which is required for the translation of mRNA targets and for dendritic filopodia formation.	Belongs to the RRM CPEB family.	NA	PE1	10
+NX_Q8NE62	Choline dehydrogenase, mitochondrial	594	65358	8.57	0	Mitochondrion inner membrane	NA	NA	NA	Belongs to the GMC oxidoreductase family.	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.;Glycine, serine and threonine metabolism;Choline catabolism	PE1	3
+NX_Q8NE63	Homeodomain-interacting protein kinase 4	616	69425	6.18	0	Cytoplasm	NA	Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).	Autophosphorylated.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.	NA	PE1	19
+NX_Q8NE65	Protein ZNF738	137	15884	4.99	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	Generic Transcription Pathway	PE1	19
+NX_Q8NE71	ATP-binding cassette sub-family F member 1	845	95926	6.4	0	Cytoplasm;Nucleoplasm;Nucleus envelope;Cytosol	NA	Is not involved in the ribosome biogenesis.;Is required for efficient Cap- and IRES-mediated mRNA translation initiation.	Is phosphorylated at phosphoserine and phosphothreonine.;Phosphorylation on Ser-109 and Ser-140 by CK2 inhibits association of EIF2 with ribosomes.	Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.	ABC-family proteins mediated transport	PE1	6
+NX_Q8NE79	Blood vessel epicardial substance	360	41451	8.02	3	Lateral cell membrane;Cell membrane;Cell junction;Membrane;Tight junction;Caveola;Sarcolemma	Muscular dystrophy, limb-girdle, autosomal recessive 25	Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.	NA	Belongs to the popeye family.	NA	PE1	6
+NX_Q8NE86	Calcium uniporter protein, mitochondrial	351	39867	8.83	2	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276). Participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity).	Phosphorylation by CaMK2 in heart leads to increased MCU current (PubMed:23051746, PubMed:25254481). The regulation of MCU by CaMK2 is however subject to discussion: another group was unable to reproduce these results (PubMed:25254480). Phosphorylated on tyrosines by PTK2B/PYK2, promoting oligomerization (PubMed:24800979).	Belongs to the MCU (TC 1.A.77) family.	Processing of SMDT1;Mitochondrial calcium ion transport	PE1	10
+NX_Q8NEA4	F-box only protein 36	188	22105	8.64	0	Nucleoplasm;Nucleolus	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	NA	PE1	2
+NX_Q8NEA5	Uncharacterized protein C19orf18	215	24151	9.06	1	Membrane;Golgi apparatus	NA	NA	NA	NA	NA	PE1	19
+NX_Q8NEA6	Zinc finger protein GLIS3	775	83636	8.34	0	Nucleoplasm;Nucleus	Diabetes mellitus, neonatal, with congenital hypothyroidism	Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).	NA	Belongs to the GLI C2H2-type zinc-finger protein family.	NA	PE1	9
+NX_Q8NEA9	Germ cell-less protein-like 2	526	60299	8.48	0	Nucleus matrix	NA	Possible function in spermatogenesis. Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).	NA	NA	Protein modification; protein ubiquitination.	PE1	5
+NX_Q8NEB5	Phospholipid phosphatase 5	264	29484	8.81	5	Membrane;Cytoplasmic vesicle	NA	Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.	NA	Belongs to the PA-phosphatase related phosphoesterase family.	Role of phospholipids in phagocytosis	PE1	8
+NX_Q8NEB7	Acrosin-binding protein	543	61359	5.09	0	Cytoplasmic vesicle;Nucleoplasm;Secreted;Acrosome	NA	May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.	The N-terminus is blocked.;Phosphorylated on Tyr residues in capacitated sperm.	NA	NA	PE1	12
+NX_Q8NEB9	Phosphatidylinositol 3-kinase catalytic subunit type 3	887	101549	6.37	0	Autophagosome;Late endosome;Midbody	NA	Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).	NA	Belongs to the PI3/PI4-kinase family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Regulation of autophagy;Phagosome;Tuberculosis;Macroautophagy;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;PI3K Cascade;Synthesis of PIPs at the late endosome membrane;Toll Like Receptor 9 (TLR9) Cascade;RHO GTPases Activate NADPH Oxidases	PE1	18
+NX_Q8NEC5	Cation channel sperm-associated protein 1	780	90091	7.22	6	Flagellum membrane	Spermatogenic failure 7	Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.	NA	Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.	Sperm Motility And Taxes	PE1	11
+NX_Q8NEC7	Glutathione S-transferase C-terminal domain-containing protein	633	71079	8.04	0	Cytoplasm;Nucleoplasm	NA	NA	NA	Belongs to the GSTCD family.	NA	PE1	4
+NX_Q8NEE0	Putative uncharacterized protein KLHL30-AS1	82	9662	10.17	0	NA	NA	NA	NA	NA	NA	PE5	2
+NX_Q8NEE6	Dynein regulatory complex subunit 6	735	83924	9.03	0	Flagellum axoneme	NA	Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	Belongs to the DRC6 family.	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	7
+NX_Q8NEE8	Tetratricopeptide repeat protein 16	873	98309	9.15	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_Q8NEF3	Coiled-coil domain-containing protein 112	446	53565	9.48	0	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	5
+NX_Q8NEF9	Serum response factor-binding protein 1	429	48634	9.59	0	Nucleoplasm;Perinuclear region;Nucleolus;Cytoplasmic vesicle	NA	May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).	NA	NA	NA	PE1	5
+NX_Q8NEG0	Protein FAM71C	241	27472	6.53	0	NA	NA	NA	NA	Belongs to the FAM71 family.	NA	PE1	12
+NX_Q8NEG2	Uncharacterized protein C7orf57	295	32846	7.78	0	NA	NA	NA	NA	NA	NA	PE1	7
+NX_Q8NEG4	Protein FAM83F	500	55486	8.38	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the FAM83 family.	NA	PE1	22
+NX_Q8NEG5	E3 ubiquitin-protein ligase ZSWIM2	633	72732	8.95	0	NA	NA	E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.	Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome (By similarity).	NA	NA	PE1	2
+NX_Q8NEG7	Protein DENND6B	585	66464	9.11	0	Recycling endosome;Cytoplasm;Cell membrane	NA	Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.	NA	Belongs to the DENND6 family.	RAB GEFs exchange GTP for GDP on RABs	PE1	22
+NX_Q8NEH6	Meiosis-specific nuclear structural protein 1	495	60571	6.73	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis.	NA	Belongs to the MNS1 family.	NA	PE1	15
+NX_Q8NEJ0	Dual specificity protein phosphatase 18	188	21066	7.04	0	Cytoplasm;Nucleoplasm;Mitochondrion inner membrane;Nucleus	NA	Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	22
+NX_Q8NEJ9	Neuroguidin	315	35894	9.57	0	Cytoplasm;Mitochondrion;Nucleolus;Nucleoplasm;Centromere;Filopodium;Axon;Dendrite;Nucleus	NA	Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.	NA	Belongs to the SAS10 family.	NA	PE1	14
+NX_Q8NEK5	Zinc finger protein 548	533	62728	8.37	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8NEK8	Terminal nucleotidyltransferase 5D	389	44500	6.17	0	NA	NA	Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase.	NA	Belongs to the TENT family.	NA	PE1	X
+NX_Q8NEL0	Coiled-coil domain-containing protein 54	328	37886	8.61	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_Q8NEL9	Phospholipase DDHD1	900	100435	5.42	0	Cytoplasm	Spastic paraplegia 28, autosomal recessive	Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity (PubMed:22922100). Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:17428803).	NA	Belongs to the PA-PLA1 family.	Synthesis of PA	PE1	14
+NX_Q8NEM0	Microcephalin	835	92849	8.56	0	Nucleoplasm;Centrosome;Nucleus	Microcephaly 1, primary, autosomal recessive	Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.	NA	NA	Condensation of Prophase Chromosomes	PE1	8
+NX_Q8NEM1	Zinc finger protein 680	530	61798	9.19	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q8NEM2	SHC SH2 domain-binding protein 1	672	75690	4.66	0	Nucleus;Spindle;Midbody;Cytoskeleton	NA	May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.	NA	NA	NA	PE1	16
+NX_Q8NEM7	Transcription factor SPT20 homolog	779	85789	8.77	0	Nucleolus;Nucleus	NA	Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.	NA	Belongs to the SPT20 family.	HATs acetylate histones	PE1	13
+NX_Q8NEM8	Cytosolic carboxypeptidase 3	1001	116011	8.98	0	Cytosol;Nucleus speckle;Mitochondrion	NA	Metallocarboxypeptidase that mediates tubulin deglutamylation.;Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.	NA	Belongs to the peptidase M14 family.	Carboxyterminal post-translational modifications of tubulin	PE2	7
+NX_Q8NEN0	Armadillo repeat-containing protein 2	867	96867	8.53	0	Cytoplasm;Nucleoplasm;Nucleus	Spermatogenic failure 38	Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity).	NA	NA	NA	PE1	6
+NX_Q8NEN9	PDZ domain-containing protein 8	1154	128563	5.78	1	Endoplasmic reticulum membrane;Nucleolus;Cell membrane	NA	Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406).	NA	NA	NA	PE1	10
+NX_Q8NEP3	Dynein assembly factor 1, axonemal	725	80026	4.57	0	Cytoplasm;Nucleus speckle;Cell membrane;Cilium;Spindle pole;Cytosol	Ciliary dyskinesia, primary, 13	Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli.	NA	Belongs to the DNAAF1 family.	NA	PE1	16
+NX_Q8NEP4	Uncharacterized protein C17orf47	570	63111	9.29	0	NA	NA	NA	NA	NA	NA	PE1	17
+NX_Q8NEP7	Kelch domain-containing protein 9	349	37754	8.71	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	1
+NX_Q8NEP9	Zinc finger protein 555	628	73084	9.26	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8NEQ5	Transmembrane protein C1orf162	155	16886	9.05	1	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q8NEQ6	Steroid receptor-associated and regulated protein	169	17657	9.23	0	Nucleoplasm	NA	May regulate the transcriptional function of androgen and estrogen receptors.	NA	NA	NA	PE1	1
+NX_Q8NER1	Transient receptor potential cation channel subfamily V member 1	839	94956	6.9	6	Postsynaptic cell membrane;Endoplasmic reticulum;Dendritic spine membrane;Cell membrane	NA	Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.	Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.;TRPV1 is phosphorylated by CDK5	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.	Neuroactive ligand-receptor interaction;TRP channels	PE1	17
+NX_Q8NER5	Activin receptor type-1C	493	54871	8.22	1	Membrane	NA	Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.	NA	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF-beta signaling pathway;Signaling by NODAL;Signaling by Activin;Regulation of signaling by NODAL	PE1	2
+NX_Q8NES3	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe	379	41773	9.35	1	Golgi apparatus membrane	Spondylocostal dysostosis 3, autosomal recessive	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity).	A soluble form may be derived from the membrane form by proteolytic processing.	Belongs to the glycosyltransferase 31 family.	Other types of O-glycan biosynthesis;Notch signaling pathway;Pre-NOTCH Processing in Golgi;Defective LFNG causes SCDO3	PE1	7
+NX_Q8NES8	Beta-defensin 124	71	8058	8.26	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	20
+NX_Q8NET1	Beta-defensin 108B	73	8326	8.65	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE2	11
+NX_Q8NET4	Retrotransposon Gag-like protein 9	1388	144280	5.81	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_Q8NET5	NFAT activation molecule 1	270	29686	9.04	1	Cell membrane	NA	May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.	N-glycosylated.	NA	Neutrophil degranulation	PE1	22
+NX_Q8NET6	Carbohydrate sulfotransferase 13	341	38920	10.56	1	Golgi apparatus membrane	NA	Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.	NA	Belongs to the sulfotransferase 2 family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Sulfur metabolism;Chondroitin sulfate biosynthesis	PE1	3
+NX_Q8NET8	Transient receptor potential cation channel subfamily V member 3	790	90636	6.17	6	Membrane;Cytosol;Centrosome;Cell membrane	Palmoplantar keratoderma, non-epidermolytic, focal 2;Olmsted syndrome	Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).	NA	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily.	TRP channels	PE1	17
+NX_Q8NEU8	DCC-interacting protein 13-beta	664	74493	4.87	0	Cytoplasm;Cell membrane;Endosome membrane;Phagosome membrane;Early endosome membrane;Phagosome;Ruffle;Ruffle membrane;Nucleus	NA	Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity).	NA	NA	NA	PE1	12
+NX_Q8NEV1	Casein kinase II subunit alpha 3	391	45220	8.54	0	NA	NA	Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.	NA	PE1	11
+NX_Q8NEV4	Myosin-IIIa	1616	186208	9.04	0	Cytoplasm;Filopodium tip;Cell membrane;Stereocilium;Cytosol;Cytoskeleton	Deafness, autosomal recessive, 30	Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity).	Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.;In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	10
+NX_Q8NEV8	Exophilin-5	1989	222519	7.98	0	NA	Epidermolysis bullosa, non-specific, autosomal recessive	May act as Rab effector protein and play a role in vesicle trafficking.	NA	NA	NA	PE1	11
+NX_Q8NEV9	Interleukin-27 subunit alpha	243	27493	6.18	0	Secreted	NA	Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication.	O-glycosylated.	Belongs to the IL-6 superfamily.	Interleukin-27 signaling	PE1	16
+NX_Q8NEW0	Zinc transporter 7	376	41626	6.43	6	Golgi apparatus;trans-Golgi network membrane	NA	Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).	NA	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.	Insulin processing;Zinc efflux and compartmentalization by the SLC30 family	PE1	1
+NX_Q8NEW7	Transmembrane inner ear expressed protein	156	17241	9.43	1	Membrane;Cytoplasmic vesicle;Cytosol	Deafness, autosomal recessive, 6	Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain.	NA	NA	NA	PE1	3
+NX_Q8NEX5	Protein WFDC9	89	10506	7.5	0	Secreted	NA	NA	NA	NA	NA	PE1	20
+NX_Q8NEX6	Protein WFDC11	87	10340	8.75	0	Secreted	NA	NA	NA	NA	NA	PE2	20
+NX_Q8NEX9	Short-chain dehydrogenase/reductase family 9C member 7	313	35263	9.26	0	Cytoplasm	Ichthyosis, congenital, autosomal recessive 13	Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	The canonical retinoid cycle in rods (twilight vision)	PE1	12
+NX_Q8NEY1	Neuron navigator 1	1877	202472	8.2	0	Cytoskeleton	NA	May be involved in neuronal migration.	NA	Belongs to the Nav/unc-53 family.	NA	PE1	1
+NX_Q8NEY3	Spermatogenesis-associated protein 4	305	34751	9.86	0	Nucleus	NA	May play a role in apoptosis regulation.	NA	NA	NA	PE1	4
+NX_Q8NEY4	V-type proton ATPase subunit C 2	427	48759	5.82	0	Mitochondrion	NA	Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	NA	Belongs to the V-ATPase C subunit family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	2
+NX_Q8NEY8	Periphilin-1	458	52737	9.15	0	Golgi apparatus;Cytoplasm;Chromosome;Nucleoplasm;Nucleus	NA	Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457).	Substrate of transglutaminase (in vitro).	NA	NA	PE1	12
+NX_Q8NEZ2	Vacuolar protein sorting-associated protein 37A	397	44314	5.37	0	Late endosome membrane;Centrosome;Cytoplasmic vesicle;Cytosol;Nucleus	Spastic paraplegia 53, autosomal recessive	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.	NA	Belongs to the VPS37 family.	Endocytosis;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	8
+NX_Q8NEZ3	WD repeat-containing protein 19	1342	151581	5.94	0	Photoreceptor outer segment;Nucleoplasm;Cilium;Cilium basal body	Short-rib thoracic dysplasia 5 with or without polydactyly;Senior-Loken syndrome 8;Cranioectodermal dysplasia 4;Nephronophthisis 13	As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly (PubMed:20889716). Essential for functional IFT-A assembly and ciliary entry of GPCRs (PubMed:20889716). Associates with the BBSome complex to mediate ciliary transport (By similarity).	NA	NA	Intraflagellar transport;Hedgehog 'off' state	PE1	4
+NX_Q8NEZ4	Histone-lysine N-methyltransferase 2C	4911	541370	6.07	0	Nucleoplasm;Nucleus	Kleefstra syndrome 2	Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	Lysine degradation;PKMTs methylate histone lysines;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	7
+NX_Q8NEZ5	F-box only protein 22	403	44508	6.61	0	Z line	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	15
+NX_Q8NF37	Lysophosphatidylcholine acyltransferase 1	534	59151	5.77	1	Endoplasmic reticulum;Golgi apparatus membrane;Endoplasmic reticulum membrane;Lipid droplet	NA	Possesses both acyltransferase and acetyltransferase activities (PubMed:16864775, PubMed:21498505). Activity is calcium-independent (By similarity). Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (PubMed:21498505). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16704971). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16864775). Involved in the regulation of lipid droplet number and size (PubMed:25491198).	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Lipid metabolism; phospholipid metabolism.;Glycerophospholipid metabolism;Ether lipid metabolism;Metabolic pathways;Synthesis of PC;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Neutrophil degranulation	PE1	5
+NX_Q8NF50	Dedicator of cytokinesis protein 8	2099	238529	6.43	0	Cytoplasm;Mitochondrion;Cell membrane;Lamellipodium membrane;Nucleoplasm;Centrosome;Cytosol	Mental retardation, autosomal dominant 2;Hyper-IgE recurrent infection syndrome 2, autosomal recessive	Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).	In response to chemokine CXCL12/SDF-1-alpha stimulation, phosphorylated by PRKCA/PKC-alpha which promotes DOCK8 dissociation from LRCH1.	Belongs to the DOCK family.	Factors involved in megakaryocyte development and platelet production	PE1	9
+NX_Q8NF64	Zinc finger MIZ domain-containing protein 2	920	96537	6.68	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.	NA	NA	NA	PE1	7
+NX_Q8NF67	Putative ankyrin repeat domain-containing protein 20A12 pseudogene	263	31171	5.19	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q8NF86	Serine protease 33	280	29787	10.03	0	Secreted	NA	Serine protease that has amidolytic activity, cleaving its substrates before Arg residues.	NA	Belongs to the peptidase S1 family.	NA	PE1	16
+NX_Q8NF91	Nesprin-1	8797	1011086	5.37	1	Golgi apparatus;Nucleus outer membrane;Nucleus membrane;Sarcomere;Nucleoplasm;Nucleus envelope;Nucleus;Cytoskeleton	Spinocerebellar ataxia, autosomal recessive, 8;Emery-Dreifuss muscular dystrophy 4, autosomal dominant	Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.	The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces.	Belongs to the nesprin family.	Meiotic synapsis	PE1	6
+NX_Q8NF99	Zinc finger protein 397	534	61139	6.93	0	Cytoplasm;Cell membrane;Nucleolus;Cytosol;Nucleus;Cytoskeleton	NA	Acts as a DNA-dependent transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	18
+NX_Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	1604	181656	6.01	0	Membrane;Golgi apparatus;Cytosol	NA	NA	NA	Belongs to the peptidase C19 family.	NA	PE1	17
+NX_Q8NFA2	NADPH oxidase organizer 1	376	41253	9.9	0	Cell membrane	NA	Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.;Is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.	NA	NA	RHO GTPases Activate NADPH Oxidases	PE1	16
+NX_Q8NFB2	Transmembrane protein 185A	350	40631	6.79	7	Membrane;Dendrite	NA	NA	NA	Belongs to the TMEM185 family.	NA	PE1	X
+NX_Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	3051	330466	5	0	Cytoplasm;Nucleoplasm;Chromosome	NA	Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).	NA	Belongs to the BOD1 family.	NA	PE1	4
+NX_Q8NFD2	Ankyrin repeat and protein kinase domain-containing protein 1	765	84632	6.6	0	NA	NA	NA	NA	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	NA	PE2	11
+NX_Q8NFD4	Uncharacterized protein FLJ76381	153	16997	11.11	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q8NFD5	AT-rich interactive domain-containing protein 1B	2236	236123	6.26	0	Nucleoplasm;Nucleolus;Nucleus	Coffin-Siris syndrome 1	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388).	NA	NA	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	6
+NX_Q8NFF2	Sodium/potassium/calcium exchanger 4	622	69042	7.48	10	Cytoplasm;Cell membrane	Amelogenesis imperfecta, hypomaturation type, 2A5	Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity).	NA	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.	Sodium/Calcium exchangers;Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)	PE1	14
+NX_Q8NFF5	FAD synthase	587	65266	6.49	0	Cytoplasm;Mitochondrion matrix;Cell membrane;Cytosol	Lipid storage myopathy due to flavin adenine dinucleotide synthetase deficiency	Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.	NA	In the N-terminal section; belongs to the MoaB/Mog family.;In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.	Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.;Riboflavin metabolism;Metabolic pathways;Vitamin B2 (riboflavin) metabolism	PE1	1
+NX_Q8NFG4	Folliculin	579	64473	5.83	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	Birt-Hogg-Dube syndrome;Renal cell carcinoma;Primary spontaneous pneumothorax	May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.	Phosphorylated. Several different phosphorylated forms exist.	Belongs to the folliculin family.	Renal cell carcinoma	PE1	17
+NX_Q8NFH3	Nucleoporin Nup43	380	42151	5.31	0	Kinetochore;Nuclear pore complex	NA	Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.	NA	NA	RNA transport;Separation of Sister Chromatids;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	6
+NX_Q8NFH4	Nucleoporin Nup37	326	36708	5.55	0	Nucleoplasm;Kinetochore;Nuclear pore complex	Microcephaly 24, primary, autosomal recessive	Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.	NA	NA	RNA transport;Separation of Sister Chromatids;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	12
+NX_Q8NFH5	Nucleoporin NUP35	326	34774	9.15	0	Nucleoplasm;Cell membrane;Nucleus membrane;Nuclear pore complex	NA	Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.	NA	Belongs to the Nup35 family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	2
+NX_Q8NFH8	RalBP1-associated Eps domain-containing protein 2	660	71534	7.56	0	Cytoplasm	NA	Involved in growth factor signaling through its influence on the Ral signaling pathway.	EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2.	NA	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	X
+NX_Q8NFI3	Cytosolic endo-beta-N-acetylglucosaminidase	743	83987	6.34	0	Cytosol;Centrosome	NA	Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.	NA	Belongs to the glycosyl hydrolase 85 family.	Other glycan degradation;N-glycan trimming in the ER and Calnexin/Calreticulin cycle	PE1	17
+NX_Q8NFI4	Putative protein FAM10A5	369	41378	4.96	0	Cytoplasm	NA	NA	NA	Belongs to the FAM10 family.	NA	PE5	11
+NX_Q8NFJ5	Retinoic acid-induced protein 3	357	40251	8.39	7	Cytoplasmic vesicle;Cytoplasmic vesicle membrane;Cell membrane	NA	Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).	Phosphorylated in two conserved double-tyrosine motifs, TYR-317/TYR-320 and TYR-347/TYR-350, by EGFR; leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. TYR-317 and TYR-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation.	Belongs to the G-protein coupled receptor 3 family.	NA	PE1	12
+NX_Q8NFJ6	Prokineticin receptor 2	384	43996	9.04	7	Cell membrane	Hypogonadotropic hypogonadism 3 with or without anosmia	Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.	NA	Belongs to the G-protein coupled receptor 1 family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	20
+NX_Q8NFJ8	Class E basic helix-loop-helix protein 22	381	36997	7.04	0	Nucleus	NA	Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.	NA	NA	NA	PE1	8
+NX_Q8NFJ9	Bardet-Biedl syndrome 1 protein	593	65083	8.02	0	Cilium membrane;Cytoplasm;Centriolar satellite;Midbody	Bardet-Biedl syndrome 1	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986). Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity).	NA	NA	BBSome-mediated cargo-targeting to cilium	PE1	11
+NX_Q8NFK1	Gap junction gamma-3 protein	279	31299	9.35	4	Gap junction;Cell membrane	NA	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Gamma-type subfamily.	NA	PE1	7
+NX_Q8NFL0	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	401	45987	9.2	1	Golgi apparatus membrane	NA	May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues.	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Glycosaminoglycan biosynthesis - keratan sulfate;O-linked glycosylation of mucins;Keratan sulfate biosynthesis	PE1	2
+NX_Q8NFM4	Adenylate cyclase type 4	1077	119794	7.31	12	Cytoplasm;Cell membrane	NA	Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	NA	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Calcium signaling pathway;Chemokine signaling pathway;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Taste transduction;GnRH signaling pathway;Progesterone-mediated oocyte maturation;Melanogenesis;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Bile secretion;HTLV-I infection;Dilated cardiomyopathy;G alpha (i) signalling events;G alpha (s) signalling events;Hedgehog 'off' state;PKA activation;PKA activation in glucagon signalling;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G alpha (z) signalling events;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway	PE1	14
+NX_Q8NFM7	Interleukin-17 receptor D	739	82411	6.78	1	Golgi apparatus;Cytoplasm;Cell membrane;Nucleoplasm;Golgi apparatus membrane	Hypogonadotropic hypogonadism 18 with or without anosmia	Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).	NA	NA	MAP2K and MAPK activation	PE1	3
+NX_Q8NFN8	Probable G-protein coupled receptor 156	814	89097	7.74	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.	Neuroactive ligand-receptor interaction	PE2	3
+NX_Q8NFP0	Peroxisomal testis-specific protein 1	134	16023	9.17	0	Peroxisome	NA	NA	NA	NA	NA	PE2	6
+NX_Q8NFP4	MAM domain-containing glycosylphosphatidylinositol anchor protein 1	955	105790	8.65	0	Golgi apparatus;Cell membrane	NA	Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	6
+NX_Q8NFP7	Diphosphoinositol polyphosphate phosphohydrolase 3-alpha	164	18500	5.52	0	Cytoplasm	NA	Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.	NA	Belongs to the Nudix hydrolase family. DIPP subfamily.	Synthesis of pyrophosphates in the cytosol	PE1	X
+NX_Q8NFP9	Neurobeachin	2946	327822	5.78	0	Cytoplasm;Golgi apparatus;Nucleolus;Membrane;Nucleoplasm;Cytosol	NA	Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).	NA	Belongs to the WD repeat neurobeachin family.	NA	PE1	13
+NX_Q8NFQ5	BPI fold-containing family B member 6	453	49717	8.97	0	Secreted	NA	NA	NA	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Antimicrobial peptides	PE1	20
+NX_Q8NFQ6	BPI fold-containing family C protein	507	56469	5.56	0	Secreted	NA	NA	NA	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	NA	PE1	22
+NX_Q8NFQ8	Torsin-1A-interacting protein 2	470	51263	4.84	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Nucleus membrane	NA	Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity.	NA	Belongs to the TOR1AIP family.	NA	PE1	1
+NX_Q8NFR3	Serine palmitoyltransferase small subunit B	76	9198	7.72	2	Endoplasmic reticulum membrane	NA	Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction.	NA	Belongs to the SPTSS family. SPTSSB subfamily.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid de novo biosynthesis	PE1	3
+NX_Q8NFR7	Coiled-coil domain-containing protein 148	591	71076	9	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	2
+NX_Q8NFR9	Interleukin-17 receptor E	667	74810	9.43	1	Cytoplasm;Secreted;Cell membrane	NA	Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens.;May act as soluble decoy receptors.;May be either cytoplasmic inactive or dominant active forms.	NA	NA	Interleukin-17 signaling	PE1	3
+NX_Q8NFT2	Metalloreductase STEAP2	490	56056	9.28	6	Cytoplasmic vesicle;Cell membrane;Endosome membrane	NA	Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).	NA	Belongs to the STEAP family.	Mineral absorption;Transferrin endocytosis and recycling	PE1	7
+NX_Q8NFT6	Protein DBF4 homolog B	615	67243	8.72	0	Nucleoplasm;Nucleus	NA	Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.	Phosphorylated.	NA	NA	PE1	17
+NX_Q8NFT8	Delta and Notch-like epidermal growth factor-related receptor	737	78475	5.03	1	Cell membrane	NA	Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).	NA	NA	Activated NOTCH1 Transmits Signal to the Nucleus	PE1	2
+NX_Q8NFU0	Bestrophin-4	473	53497	5.81	4	Cell membrane	NA	Forms calcium-sensitive chloride channels. Permeable to bicarbonate.	NA	Belongs to the bestrophin family.	Stimuli-sensing channels	PE1	1
+NX_Q8NFU1	Bestrophin-2	509	57139	5.11	4	Cell membrane	NA	Forms calcium-sensitive chloride channels. Permeable to bicarbonate.	NA	Belongs to the bestrophin family.	Salivary secretion;Stimuli-sensing channels	PE1	19
+NX_Q8NFU3	Thiosulfate:glutathione sulfurtransferase	115	12530	5.85	0	Cytosol;Perinuclear region	NA	Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631).	NA	NA	Sulfide oxidation to sulfate	PE1	1
+NX_Q8NFU4	Follicular dendritic cell secreted peptide	85	9700	9.3	0	Secreted	NA	Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.	O-glycosylated with core 1 or possibly core 8 glycans.	NA	NA	PE1	4
+NX_Q8NFU5	Inositol polyphosphate multikinase	416	47222	7.27	0	Nucleoplasm;Nucleus	NA	Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:30420721, PubMed:28882892). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity).	NA	Belongs to the inositol phosphokinase (IPK) family.	Phospholipid metabolism; phosphatidylinositol metabolism.;Inositol phosphate metabolism;Synthesis of IPs in the nucleus	PE1	10
+NX_Q8NFU7	Methylcytosine dioxygenase TET1	2136	235309	8.53	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).	Glycosylated. Interaction with OGT leads to GlcNAcylation (By similarity).	Belongs to the TET family.	TET1,2,3 and TDG demethylate DNA	PE1	10
+NX_Q8NFV4	Protein ABHD11	315	34690	9.5	0	Mitochondrion	NA	NA	NA	Belongs to the AB hydrolase superfamily.	NA	PE1	7
+NX_Q8NFV5	Speedy protein E1	336	40668	9.52	0	NA	NA	NA	NA	Belongs to the Speedy/Ringo family.	NA	PE2	7
+NX_Q8NFW1	Collagen alpha-1(XXII) chain	1626	161145	6.88	0	Endoplasmic reticulum;Cytoplasm;Extracellular matrix;Cytoplasmic vesicle	NA	Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts.	NA	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.	Collagen biosynthesis and modifying enzymes;Collagen chain trimerization	PE1	8
+NX_Q8NFW5	Diencephalon/mesencephalon homeobox protein 1	382	41198	8.76	0	Nucleus	NA	Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity).	NA	Belongs to the paired homeobox family.	NA	PE1	1
+NX_Q8NFW8	N-acylneuraminate cytidylyltransferase	434	48379	8.16	0	Nucleolus;Cytosol;Nucleus	NA	Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).	NA	Belongs to the CMP-NeuNAc synthase family.	Amino-sugar metabolism; N-acetylneuraminate metabolism.;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Sialic acid metabolism	PE1	12
+NX_Q8NFW9	Rab effector MyRIP	859	95706	5.44	0	Golgi apparatus;Cytoplasm;Nucleolus;Nucleoplasm;Perinuclear region;Secretory vesicle	NA	Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity).	NA	NA	Insulin processing	PE1	3
+NX_Q8NFX7	Syntaxin-binding protein 6	210	23554	9.19	0	Membrane;Cytoplasm	NA	Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.	NA	NA	NA	PE1	14
+NX_Q8NFY4	Semaphorin-6D	1073	119872	8.77	1	Golgi apparatus;Cytoplasm;Cell membrane	NA	Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.	NA	Belongs to the semaphorin family.	Axon guidance;Other semaphorin interactions	PE1	15
+NX_Q8NFY9	Kelch repeat and BTB domain-containing protein 8	601	68823	5.88	0	Golgi apparatus;Spindle	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).	NA	Belongs to the KBTBD8 family.	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	3
+NX_Q8NFZ0	F-box DNA helicase 1	1043	117686	8.58	0	Nucleus;Chromosome	NA	3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578).	Ubiquitinated (PubMed:23393192, PubMed:23677613). Ubiquitination by the DCX(DTL) complex, also named CRL4(CDT2), leading to its degradation: ubiquitination takes place after its localization to DNA damage sites, possibly to facilitate the translesion synthesis (TLS) pathway (PubMed:23677613).	Belongs to the helicase family. UvrD subfamily.	Protein modification; protein ubiquitination.	PE1	10
+NX_Q8NFZ3	Neuroligin-4, Y-linked	816	92021	5.77	1	Postsynaptic density;Cell membrane	NA	Putative neuronal cell surface protein involved in cell-cell-interactions.	NA	Belongs to the type-B carboxylesterase/lipase family.	Neurexins and neuroligins	PE2	Y
+NX_Q8NFZ4	Neuroligin-2	835	90820	5.78	1	Postsynaptic cell membrane;Mitochondrion;Presynaptic cell membrane;Cell membrane	NA	Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).	NA	Belongs to the type-B carboxylesterase/lipase family.	Cell adhesion molecules (CAMs);Neurexins and neuroligins	PE1	17
+NX_Q8NFZ5	TNFAIP3-interacting protein 2	429	48700	6.03	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.	In vitro phosphorylated by CHUK.;Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination.	NA	MAP3K8 (TPL2)-dependent MAPK1/3 activation;Ovarian tumor domain proteases	PE1	4
+NX_Q8NFZ6	Vomeronasal type-1 receptor 2	395	44476	9.52	8	Cell membrane	NA	Putative pheromone receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	19
+NX_Q8NFZ8	Cell adhesion molecule 4	388	42785	5.92	1	Membrane;Nucleoplasm;Nucleus membrane	NA	Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.	N-glycosylated.	Belongs to the nectin family.	NA	PE1	19
+NX_Q8NG04	Solute carrier family 26 member 10	563	60059	8.6	5	Membrane	NA	Chloride/bicarbonate exchanger.	NA	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	NA	PE2	12
+NX_Q8NG06	E3 ubiquitin-protein ligase TRIM58	486	54766	5.87	0	NA	NA	E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.	NA	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.	PE1	1
+NX_Q8NG08	DNA helicase B	1087	123252	5.59	0	Cytoplasm;Nucleus;Chromosome	NA	5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613).	Phosphorylated at Ser-967 by CDK2 during the G1/S transition, resulting in its nuclear export into the cytoplasm (PubMed:15146062, PubMed:26774285). As S phase progresses, its exclusion from the nucleus promotes the activation of long-range resection (PubMed:26774285).	Belongs to the RecD family. HELB subfamily.	NA	PE1	12
+NX_Q8NG11	Tetraspanin-14	270	30691	6.41	4	Cytoplasmic vesicle;Cell membrane	NA	Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).	NA	Belongs to the tetraspanin (TM4SF) family.	Amyloid fiber formation;Neutrophil degranulation	PE1	10
+NX_Q8NG27	E3 ubiquitin-protein ligase Praja-1	643	71002	5.05	0	Nucleoplasm;Nucleolus	NA	Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.	Substrate for E2-dependent ubiquitination.	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	X
+NX_Q8NG31	Kinetochore scaffold 1	2342	265391	5.3	0	Nucleoplasm;Nucleus;Kinetochore	Microcephaly 4, primary, autosomal recessive	Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.	NA	NA	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	15
+NX_Q8NG35	Beta-defensin 105	78	8923	8.71	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	8
+NX_Q8NG41	Neuropeptide B	125	13097	9.97	0	Secreted	NA	May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.	NA	Belongs to the neuropeptide B/W family.	G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	17
+NX_Q8NG48	Protein Lines homolog 1	757	85857	6.07	0	Nucleoplasm	Mental retardation, autosomal recessive 27	NA	NA	Belongs to the protein lines family.	NA	PE1	15
+NX_Q8NG50	RAD52 motif-containing protein 1	284	31970	5.75	0	Cajal body;Cytoplasm;Nucleolus;PML body;Cytosol;Nucleus	NA	May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA.	NA	NA	NA	PE1	17
+NX_Q8NG57	Elongin-A3	546	59744	9.86	0	Nucleus	NA	SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).	NA	NA	Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes	PE1	18
+NX_Q8NG66	Serine/threonine-protein kinase Nek11	645	74192	5	0	Nucleoplasm;Nucleus;Nucleolus	NA	Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.	Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.;NEK11 is phosphorylated by NEK2	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	NA	PE1	3
+NX_Q8NG68	Tubulin--tyrosine ligase	377	43212	6.28	0	Nucleoplasm;Cytoplasmic vesicle	NA	Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.	NA	Belongs to the tubulin--tyrosine ligase family.	Carboxyterminal post-translational modifications of tubulin	PE1	2
+NX_Q8NG75	Olfactory receptor 5T1	326	36885	7.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NG76	Olfactory receptor 2T33	320	35876	8.91	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NG77	Olfactory receptor 2T12	320	35946	8.96	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NG78	Olfactory receptor 8G5	346	38798	8.65	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NG80	Olfactory receptor 2L5	312	35648	8.87	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	1
+NX_Q8NG81	Olfactory receptor 2M7	312	34902	7.52	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NG83	Olfactory receptor 2M3	312	34827	8.45	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NG84	Olfactory receptor 2AK2	335	37763	9.23	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NG85	Olfactory receptor 2L3	312	35282	8.96	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NG92	Olfactory receptor 13H1	308	34570	9.25	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	X
+NX_Q8NG94	Olfactory receptor 11H1	326	36578	8.35	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	22
+NX_Q8NG95	Olfactory receptor 7G3	312	34439	8.53	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_Q8NG97	Olfactory receptor 2Z1	314	34444	7.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_Q8NG98	Olfactory receptor 7D4	312	34448	7.05	7	Cell membrane	NA	Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_Q8NG99	Olfactory receptor 7G2	324	35931	8.51	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_Q8NGA0	Olfactory receptor 7G1	311	34803	8.77	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	19
+NX_Q8NGA1	Olfactory receptor 1M1	313	34840	9.18	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_Q8NGA2	Putative olfactory receptor 7A2	310	34430	6.42	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	19
+NX_Q8NGA4	Putative G-protein coupled receptor GPR32P1	272	30291	9.49	5	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE5	19
+NX_Q8NGA5	Olfactory receptor 10H4	316	35765	8.92	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	19
+NX_Q8NGA6	Olfactory receptor 10H5	315	34900	8.92	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_Q8NGA8	Olfactory receptor 4F17	305	34212	8.69	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_Q8NGB2	Olfactory receptor 4C5	326	36862	6.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_Q8NGB4	Olfactory receptor 4S1	309	34800	9	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGB6	Olfactory receptor 4M2	313	35416	7.48	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	15
+NX_Q8NGB8	Olfactory receptor 4F15	312	35369	8.84	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	15
+NX_Q8NGB9	Olfactory receptor 4F6	312	35355	8.88	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	15
+NX_Q8NGC0	Olfactory receptor 5AU1	362	40658	9.24	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGC1	Olfactory receptor 11G2	345	38871	9.47	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGC2	Olfactory receptor 4E2	313	35466	8.26	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGC3	Olfactory receptor 10G2	310	34472	9.04	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGC4	Olfactory receptor 10G3	313	35055	9.17	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGC5	Olfactory receptor 6J1	347	38693	8.84	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	14
+NX_Q8NGC6	Olfactory receptor 4K17	315	35312	8.97	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGC7	Olfactory receptor 11H6	330	36788	8.59	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGC8	Olfactory receptor 11H7	314	35499	8.71	7	Cell membrane	NA	Odorant receptor. Activated by isovaleric acid.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	14
+NX_Q8NGC9	Olfactory receptor 11H4	324	36886	9.05	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGD0	Olfactory receptor 4M1	313	35488	8.41	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGD1	Olfactory receptor 4N2	307	34721	9.06	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGD2	Olfactory receptor 4K2	314	35357	7.59	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGD3	Olfactory receptor 4K5	323	36258	8.77	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	14
+NX_Q8NGD4	Olfactory receptor 4K1	311	35201	6.43	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NGD5	Olfactory receptor 4K14	310	35053	8.46	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	14
+NX_Q8NGE0	Olfactory receptor 10AD1	317	35698	8.46	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_Q8NGE1	Olfactory receptor 6C4	309	35010	8.91	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_Q8NGE2	Olfactory receptor 2AP1	309	34902	8.66	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	12
+NX_Q8NGE3	Olfactory receptor 10P1	313	34741	9.77	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_Q8NGE5	Olfactory receptor 10A7	316	35695	8.78	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_Q8NGE7	Olfactory receptor 9K2	335	37746	8.68	6	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_Q8NGE8	Olfactory receptor 4D9	314	35666	9.08	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGE9	Olfactory receptor 9Q2	314	35363	8.83	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGF0	Olfactory receptor 52B6	335	36963	8.61	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGF1	Olfactory receptor 52R1	315	34943	8.49	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGF3	Olfactory receptor 51D1	324	35839	8.99	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGF4	Olfactory receptor 5AP2	316	35508	8.9	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGF6	Olfactory receptor 10W1	305	33376	6.83	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	11
+NX_Q8NGF7	Olfactory receptor 5B17	314	35091	7.56	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGF8	Olfactory receptor 4B1	309	34456	7.54	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGF9	Olfactory receptor 4X2	303	34289	8.75	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGG0	Olfactory receptor 8J3	315	35481	8.62	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGG1	Olfactory receptor 8J2	315	35160	8.51	7	Membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_Q8NGG2	Olfactory receptor 5T2	359	40696	8.91	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGG3	Olfactory receptor 5T3	340	38346	8.3	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGG4	Olfactory receptor 8H1	311	35228	9.03	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGG5	Olfactory receptor 8K1	319	36581	9.18	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGG6	Olfactory receptor 8B12	310	34372	8.51	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGG7	Olfactory receptor 8A1	326	36388	8.69	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGG8	Olfactory receptor 8B3	313	35305	9.07	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	11
+NX_Q8NGH3	Olfactory receptor 2D3	330	37489	9.21	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGH5	Olfactory receptor 56A1	318	35823	9.03	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGH6	Putative olfactory receptor 52L2	319	35227	8.98	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	11
+NX_Q8NGH7	Olfactory receptor 52L1	329	36221	8.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGH8	Olfactory receptor 56A4	313	35116	9.03	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGH9	Olfactory receptor 52E4	312	35480	8.84	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGI0	Olfactory receptor 52N2	321	35940	8.35	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGI1	Putative olfactory receptor 56B2	322	35955	8.99	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	11
+NX_Q8NGI2	Olfactory receptor 52N4	321	36080	8.48	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGI3	Olfactory receptor 56B1	324	36050	8.5	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGI4	Olfactory receptor 4D11	311	34969	9.06	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGI6	Olfactory receptor 4D10	311	35300	9.07	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGI7	Olfactory receptor 10V1	309	34746	8.69	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGI8	Olfactory receptor 5AN1	311	34789	8.83	7	Cell membrane	NA	Odorant receptor involved in the detection of muscone, cyclopentadecanone, cyclopentadecanol, and omega-pentadecalactone (PubMed:24361078, PubMed:25901328). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Probable).	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGI9	Olfactory receptor 5A2	324	36016	8.46	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGJ0	Olfactory receptor 5A1	315	35152	8.53	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGJ1	Olfactory receptor 4D6	314	35954	8.75	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGJ2	Olfactory receptor 52H1	320	35592	8.18	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGJ3	Olfactory receptor 52E1	308	34714	8.64	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_Q8NGJ4	Olfactory receptor 52E2	325	36630	8.69	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGJ5	Olfactory receptor 51L1	315	35369	7.65	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGJ6	Olfactory receptor 51A4	313	35256	9.15	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGJ7	Olfactory receptor 51A2	313	35078	9.06	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGJ8	Olfactory receptor 51S1	323	35313	9.13	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGJ9	Olfactory receptor 51T1	327	36998	9.45	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGK0	Olfactory receptor 51G2	314	35012	8.93	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGK1	Olfactory receptor 51G1	321	36290	8.97	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGK2	Olfactory receptor 52B4	314	35584	8.82	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction	PE3	11
+NX_Q8NGK3	Olfactory receptor 52K2	314	34926	8.8	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGK4	Olfactory receptor 52K1	314	35231	8.97	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGK5	Olfactory receptor 52M1	317	35037	8.99	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGK6	Olfactory receptor 52I1	324	35386	7.16	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGK9	Olfactory receptor 5D16	328	37278	8.62	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGL0	Olfactory receptor 5L2	311	34682	8.46	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGL1	Olfactory receptor 5D18	313	35348	8.68	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGL2	Olfactory receptor 5L1	311	34559	8.29	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGL3	Olfactory receptor 5D14	314	35823	9.01	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGL4	Olfactory receptor 5D13	314	35447	8.19	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGL6	Olfactory receptor 4A15	344	38828	9.01	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGL7	Olfactory receptor 4P4	312	35795	8.76	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGL9	Olfactory receptor 4C16	310	34991	8.8	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGM1	Olfactory receptor 4C15	316	35667	8.02	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGM8	Olfactory receptor 6M1	313	35328	8.54	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGM9	Olfactory receptor 8D4	314	35019	9.04	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGN0	Olfactory receptor 4D5	318	35771	8.95	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGN1	Olfactory receptor 6T1	323	36348	9.39	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGN2	Olfactory receptor 10S1	331	36501	8.47	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGN3	Olfactory receptor 10G4	311	34569	8.99	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGN4	Olfactory receptor 10G9	311	34574	8.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGN5	Olfactory receptor 10G8	311	34519	9.14	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGN6	Olfactory receptor 10G7	311	34517	8.85	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGN7	Putative olfactory receptor 10D4	298	33107	8.33	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	11
+NX_Q8NGN8	Putative olfactory receptor 4A4	299	33593	8.83	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	11
+NX_Q8NGP0	Olfactory receptor 4C13	309	34582	8.72	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGP2	Olfactory receptor 8J1	316	35415	8.61	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGP3	Olfactory receptor 5M9	310	35093	8.7	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGP4	Olfactory receptor 5M3	307	35156	9.19	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGP6	Olfactory receptor 5M8	311	35603	8.78	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGP8	Olfactory receptor 5M1	315	35608	8.41	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGP9	Olfactory receptor 5AR1	310	34815	7.52	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGQ1	Olfactory receptor 9G4	327	36344	8.25	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGQ2	Olfactory receptor 6Q1	317	35736	8.32	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGQ3	Olfactory receptor 1S2	325	36579	7.63	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGQ4	Olfactory receptor 10Q1	319	35602	8.16	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGQ5	Olfactory receptor 9Q1	310	34757	5.72	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NGQ6	Olfactory receptor 9I1	314	34908	9	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NGR1	Olfactory receptor 13A1	328	36494	8.7	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	10
+NX_Q8NGR2	Olfactory receptor 1L6	347	39515	9.6	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	9
+NX_Q8NGR3	Olfactory receptor 1K1	316	34268	8.1	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGR4	Olfactory receptor 5C1	320	34991	8.88	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGR5	Olfactory receptor 1L4	311	35277	9.44	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGR6	Olfactory receptor 1B1	318	35293	8.48	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGR8	Olfactory receptor 1L8	309	35083	8.96	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGR9	Olfactory receptor 1N2	330	36889	7.98	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGS0	Olfactory receptor 1N1	311	34650	7.92	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGS1	Olfactory receptor 1J4	313	34959	6.42	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGS2	Olfactory receptor 1J2	313	35385	6.48	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGS3	Olfactory receptor 1J1	322	35493	7.96	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGS4	Olfactory receptor 13F1	319	35646	8.94	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGS5	Olfactory receptor 13C4	318	35576	9.3	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	9
+NX_Q8NGS6	Olfactory receptor 13C3	347	38729	8.83	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGS7	Olfactory receptor 13C8	320	35294	8.47	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGS8	Olfactory receptor 13C5	318	35796	8.53	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGS9	Olfactory receptor 13C2	318	35694	7.58	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGT0	Olfactory receptor 13C9	318	35854	8.56	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGT1	Olfactory receptor 2K2	316	35045	8.55	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGT2	Olfactory receptor 13J1	312	34689	8.87	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGT5	Olfactory receptor 9A2	310	35330	8.84	6	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_Q8NGT7	Olfactory receptor 2A12	310	35213	9.24	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_Q8NGT9	Olfactory receptor 2A1/2A42	310	34714	8.9	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory transduction;Olfactory Signaling Pathway	PE3	7
+NX_Q8NGU1	Putative olfactory receptor 9A1	263	29546	7.46	6	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	7
+NX_Q8NGU2	Olfactory receptor 9A4	314	35758	8.8	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_Q8NGU4	Putative olfactory receptor 2I1	316	34115	9.61	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	6
+NX_Q8NGU9	Probable G-protein coupled receptor 150	434	46353	10.17	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (s) signalling events	PE1	5
+NX_Q8NGV0	Olfactory receptor 2Y1	311	34731	8.66	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	5
+NX_Q8NGV5	Olfactory receptor 13D1	346	39125	7.53	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NGV6	Olfactory receptor 5H6	325	36713	6.64	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	3
+NX_Q8NGV7	Olfactory receptor 5H2	314	35974	7.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	3
+NX_Q8NGW1	Olfactory receptor 6B3	331	37232	8.53	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	2
+NX_Q8NGW6	Olfactory receptor 6K6	343	38362	8.39	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGX0	Olfactory receptor 11L1	322	36763	9.22	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGX1	Olfactory receptor 2T34	318	35681	8.7	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGX2	Olfactory receptor 2T35	323	36101	9.03	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	1
+NX_Q8NGX3	Olfactory receptor 10T2	314	35011	9.24	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	1
+NX_Q8NGX5	Olfactory receptor 10K1	313	35079	9.33	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGX6	Olfactory receptor 10R2	335	37486	8.88	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGX8	Olfactory receptor 6Y1	325	36636	8.38	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGX9	Olfactory receptor 6P1	317	35831	8.77	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	1
+NX_Q8NGY0	Olfactory receptor 10X1	326	36446	8.51	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGY1	Olfactory receptor 10Z1	313	34609	8.48	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGY2	Olfactory receptor 6K2	324	36513	8.21	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGY3	Olfactory receptor 6K3	331	37352	6.97	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGY5	Olfactory receptor 6N1	312	34869	8.63	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGY6	Olfactory receptor 6N2	317	35692	9.08	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGY7	Putative olfactory receptor 10J6	276	31021	8.87	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	1
+NX_Q8NGY9	Olfactory receptor 2L8	312	35444	8.86	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGZ0	Olfactory receptor 2AJ1	328	37063	9.12	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	1
+NX_Q8NGZ2	Olfactory receptor 14K1	314	34861	8.77	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	1
+NX_Q8NGZ3	Olfactory receptor 13G1	307	34672	8.52	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGZ4	Olfactory receptor 2G3	309	34506	8.04	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGZ5	Olfactory receptor 2G2	317	35559	9.44	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	1
+NX_Q8NGZ6	Olfactory receptor 6F1	308	33961	8.9	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NGZ9	Olfactory receptor 2T10	312	35403	8.81	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NH00	Olfactory receptor 2T4	348	39414	7.2	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NH01	Olfactory receptor 2T11	316	34797	8.18	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NH02	Olfactory receptor 2T29	315	35595	8.59	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NH03	Olfactory receptor 2T3	318	35598	8.42	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NH04	Olfactory receptor 2T27	317	35514	8.47	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NH05	Olfactory receptor 4Q3	313	35491	7.83	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NH06	Olfactory receptor 1P1	330	36638	8.32	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	17
+NX_Q8NH07	Olfactory receptor 11H2	326	36531	8.35	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	14
+NX_Q8NH08	Olfactory receptor 10AC1	325	35157	9.34	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	7
+NX_Q8NH09	Olfactory receptor 8S1	359	39645	8.84	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_Q8NH10	Olfactory receptor 8U1	309	35088	7.97	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NH16	Olfactory receptor 2L2	312	35495	8.94	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NH18	Olfactory receptor 5J2	312	34808	8.3	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH19	Olfactory receptor 10AG1	301	34105	9.07	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH21	Olfactory receptor 4F5	305	34330	8.53	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	1
+NX_Q8NH37	Olfactory receptor 4C3	302	33726	6.68	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH40	Olfactory receptor 6S1	331	36127	8.66	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NH41	Olfactory receptor 4K15	348	39088	9.1	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NH42	Olfactory receptor 4K13	304	34261	9.04	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	14
+NX_Q8NH43	Olfactory receptor 4L1	312	35264	9.03	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	14
+NX_Q8NH48	Olfactory receptor 5B3	314	35258	6.48	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NH49	Olfactory receptor 4X1	305	34222	8.74	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NH50	Olfactory receptor 8K5	307	35190	6.48	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NH51	Olfactory receptor 8K3	312	35463	8.02	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NH53	Olfactory receptor 52N1	320	35785	8.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH54	Olfactory receptor 56A3	315	35611	8.82	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH55	Olfactory receptor 52E5	327	36851	9.12	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	11
+NX_Q8NH56	Olfactory receptor 52N5	324	36212	8.88	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH57	Putative olfactory receptor 52P1	321	34890	8.69	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	11
+NX_Q8NH59	Olfactory receptor 51Q1	317	35747	8.69	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH60	Olfactory receptor 52J3	311	35091	8.82	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NH61	Olfactory receptor 51F2	342	38518	9.06	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH63	Olfactory receptor 51H1	302	33766	8.97	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_Q8NH64	Olfactory receptor 51A7	312	35132	9.12	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH67	Olfactory receptor 52I2	350	38353	8.42	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH69	Olfactory receptor 5W2	310	35167	6.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_Q8NH70	Olfactory receptor 4A16	328	36922	8.58	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH72	Olfactory receptor 4C6	309	34558	8.45	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH73	Olfactory receptor 4S2	311	35172	8.53	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NH74	Olfactory receptor 10A6	314	35318	8.37	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH76	Olfactory receptor 56B4	319	35454	8.01	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH79	Olfactory receptor 6X1	312	34727	9.1	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH80	Putative olfactory receptor 10D3	312	34812	8.31	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	11
+NX_Q8NH81	Olfactory receptor 10G6	332	36823	7.53	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	11
+NX_Q8NH83	Olfactory receptor 4A5	315	34915	8.41	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NH85	Olfactory receptor 5R1	324	36708	8.61	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NH87	Olfactory receptor 9G1	305	34071	8.14	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NH89	Putative olfactory receptor 5AK3	298	33542	7.55	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	11
+NX_Q8NH90	Olfactory receptor 5AK2	309	34627	8.42	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8NH92	Olfactory receptor 1S1	325	36707	8.79	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q8NH93	Olfactory receptor 1L3	324	36633	9.36	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NH94	Olfactory receptor 1L1	360	41046	9.01	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q8NH95	Putative olfactory receptor 13C6	151	16702	8.4	3	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE5	9
+NX_Q8NHA4	Olfactory receptor 2AE1	323	36588	9.28	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_Q8NHA6	Putative olfactory receptor 2W6	318	35283	8.66	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	6
+NX_Q8NHA8	Olfactory receptor 1F12	337	36933	7.95	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	6
+NX_Q8NHB1	Olfactory receptor 2V1	315	34857	8.92	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	5
+NX_Q8NHB7	Olfactory receptor 5K1	308	35185	8.39	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	3
+NX_Q8NHB8	Olfactory receptor 5K2	316	35763	8.37	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	3
+NX_Q8NHC4	Olfactory receptor 10J5	309	34401	8.65	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NHC5	Olfactory receptor 14A16	309	34307	8.41	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NHC6	Putative olfactory receptor 14L1	308	34709	8.72	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	1
+NX_Q8NHC7	Olfactory receptor 14C36	312	34815	8.71	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q8NHC8	Olfactory receptor 2T6	308	34765	8.38	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	1
+NX_Q8NHE4	V-type proton ATPase subunit e 2	81	9184	8.8	2	Membrane	NA	Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	NA	Belongs to the V-ATPase e1/e2 subunit family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE2	7
+NX_Q8NHG7	Small VCP/p97-interacting protein	77	8443	9.06	0	Membrane;Golgi apparatus membrane;Smooth endoplasmic reticulum membrane;Cell membrane	NA	NA	NA	Belongs to the SVIP family.	Protein processing in endoplasmic reticulum;Neutrophil degranulation	PE1	11
+NX_Q8NHG8	E3 ubiquitin-protein ligase ZNRF2	242	24115	6.64	0	Lysosome membrane;Presynaptic cell membrane;Endosome membrane	NA	May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	7
+NX_Q8NHH1	Tubulin polyglutamylase TTLL11	800	87612	9.08	0	Cilium basal body	NA	Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Generates long side-chains (By similarity).	NA	Belongs to the tubulin--tyrosine ligase family.	Carboxyterminal post-translational modifications of tubulin	PE1	9
+NX_Q8NHH9	Atlastin-2	583	66229	5.3	2	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977).	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	NA	PE1	2
+NX_Q8NHJ6	Leukocyte immunoglobulin-like receptor subfamily B member 4	448	49356	6.19	1	Cell membrane	NA	Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. Towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.	NA	NA	Osteoclast differentiation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q8NHK3	Killer cell immunoglobulin-like receptor 2DL5B	375	40695	8.08	1	Cell membrane	NA	Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.	NA	Belongs to the immunoglobulin superfamily.	NA	PE3	19
+NX_Q8NHL6	Leukocyte immunoglobulin-like receptor subfamily B member 1	650	70819	5.69	1	Secreted;Cell membrane	NA	Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251).	Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.	NA	Osteoclast differentiation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q8NHM4	Putative trypsin-6	247	26537	5.64	0	Secreted	NA	May regulate cell migration.	NA	Belongs to the peptidase S1 family. Tryptase subfamily.	NA	PE5	7
+NX_Q8NHM5	Lysine-specific demethylase 2B	1336	152615	8.85	0	Nucleoplasm;Nucleus;Nucleolus;Chromosome	NA	Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).	NA	Belongs to the JHDM1 histone demethylase family.	HDMs demethylate histones	PE1	12
+NX_Q8NHP1	Aflatoxin B1 aldehyde reductase member 4	331	36970	6.39	0	NA	NA	Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).	NA	Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.	Metabolism of xenobiotics by cytochrome P450;Aflatoxin activation and detoxification	PE1	1
+NX_Q8NHP6	Motile sperm domain-containing protein 2	518	59746	5.7	1	Endoplasmic reticulum;Cell membrane	NA	Promotes migration of primary monocytes and neutrophils, in response to various chemokines.	NA	NA	Neutrophil degranulation	PE1	X
+NX_Q8NHP7	piRNA biogenesis protein EXD1	514	58335	5.5	0	Cytoplasm	NA	RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity).	NA	Belongs to the EXD1 family.	NA	PE1	15
+NX_Q8NHP8	Putative phospholipase B-like 2	589	65472	6.34	0	Lysosome lumen	NA	Putative phospholipase.	The p76 protein is synthesized as a 80 kDa precursor which is then processed into a N-terminal 32 kDa form and a C-terminal 45 kDa form.;Glycosylated; contains mannose 6-phosphate sugars.	Belongs to the phospholipase B-like family.	NA	PE1	12
+NX_Q8NHQ1	Centrosomal protein of 70 kDa	597	69752	5.52	0	Nucleoplasm;Cytosol;Centrosome	NA	Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.	NA	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	3
+NX_Q8NHQ8	Ras association domain-containing protein 8	419	48327	6.21	0	Cytosol;Mitochondrion	NA	NA	NA	NA	NA	PE1	12
+NX_Q8NHQ9	ATP-dependent RNA helicase DDX55	600	68547	9.32	0	Nucleoplasm;Nucleolus	NA	Probable ATP-binding RNA helicase.	NA	Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.	NA	PE1	12
+NX_Q8NHR7	Telomere repeats-binding bouquet formation protein 2	220	25316	7.12	0	Nucleoplasm;Telomere;Nucleolus;Nucleus inner membrane	NA	Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA.	NA	Belongs to the TERB2 family.	NA	PE1	15
+NX_Q8NHR9	Profilin-4	129	14319	8.76	0	Cytoskeleton	NA	Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin (PubMed:19419568), contrary to other family members.	NA	Belongs to the profilin family.	Regulation of actin cytoskeleton;Shigellosis;Salmonella infection	PE1	2
+NX_Q8NHS0	DnaJ homolog subfamily B member 8	232	25686	6	0	NA	NA	Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.	NA	NA	NA	PE1	3
+NX_Q8NHS1	Claudin domain-containing protein 2	167	17984	7.56	4	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the PMP-22/EMP/MP20 family.	NA	PE2	19
+NX_Q8NHS2	Putative aspartate aminotransferase, cytoplasmic 2	421	47305	6.56	0	Cytoplasm	NA	NA	NA	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	NA	PE1	8
+NX_Q8NHS3	Major facilitator superfamily domain-containing protein 8	518	57628	6.41	12	Nucleoplasm;Cytoplasmic vesicle;Endosome;Lysosome membrane	Macular dystrophy with central cone involvement;Ceroid lipofuscinosis, neuronal, 7	May be a carrier that transport small solutes by using chemiosmotic ion gradients.	NA	Belongs to the major facilitator superfamily.	Lysosome	PE1	4
+NX_Q8NHS4	Clathrin heavy chain linker domain-containing protein 1	586	67250	6.09	0	Centrosome;Nucleolus	NA	NA	NA	NA	NA	PE1	2
+NX_Q8NHS9	Spermatogenesis-associated protein 22	363	41318	9.45	0	Chromosome	NA	Meiosis-specific protein required for homologous recombination in meiosis I.	NA	NA	NA	PE1	17
+NX_Q8NHU0	Cancer/testis antigen family 45 member A3	189	21331	9.79	0	NA	NA	NA	NA	Belongs to the CT45 family.	NA	PE1	X
+NX_Q8NHU2	Cilia- and flagella-associated protein 61	1237	141349	5.76	0	Cilium axoneme	NA	May regulate cilium motility through its role in the assembly of the axonemal radial spokes.	NA	NA	NA	PE1	20
+NX_Q8NHU3	Phosphatidylcholine:ceramide cholinephosphotransferase 2	365	42280	9.01	6	Cell membrane;Golgi apparatus membrane	NA	Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity.	Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization.	Belongs to the sphingomyelin synthase family.	Sphingolipid metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis	PE1	4
+NX_Q8NHU6	Tudor domain-containing protein 7	1098	123586	6.84	0	Nucleoplasm;Cytosol;Cytoplasm	Cataract 36	Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.	NA	Belongs to the TDRD7 family.	NA	PE1	9
+NX_Q8NHV1	GTPase IMAP family member 7	300	34509	6.1	0	Golgi apparatus;Cytoplasm;Lipid droplet;Endoplasmic reticulum;Cytoplasmic vesicle;Cytosol	NA	The dimer has GTPase activity; the active site contains residues from both subunits.	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.	NA	PE1	7
+NX_Q8NHV4	Protein NEDD1	660	71966	8.15	0	Nucleoplasm;Centrosome;Cell membrane	NA	Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.	During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	12
+NX_Q8NHV5	Modulator of smoothened protein	167	18250	8.6	4	Cilium membrane;Cell membrane	NA	Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation.	NA	NA	NA	PE2	16
+NX_Q8NHV9	Rhox homeobox family member 1	184	20542	5.77	0	Nucleus	NA	Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.	NA	Belongs to the paired-like homeobox family. PEPP subfamily.	NA	PE1	X
+NX_Q8NHW3	Transcription factor MafA	353	36982	7.49	0	Nucleus	Insulinomatosis and diabetes mellitus	Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959). Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498).	Ubiquitinated, leading to its degradation by the proteasome.;Phosphorylated at tyrosines.	Belongs to the bZIP family. Maf subfamily.	Type II diabetes mellitus;Maturity onset diabetes of the young;Regulation of gene expression in beta cells	PE1	8
+NX_Q8NHW4	C-C motif chemokine 4-like	92	10166	5.13	0	Secreted	NA	Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Cytosolic DNA-sensing pathway;Salmonella infection;Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Cytosolic DNA-sensing pathway;Salmonella infection;G alpha (i) signalling events	PE1	17
+NX_Q8NHW5	60S acidic ribosomal protein P0-like	317	34364	5.41	0	NA	NA	Ribosomal protein P0 is the functional equivalent of E.coli protein L10.	NA	Belongs to the universal ribosomal protein uL10 family.	NA	PE5	2
+NX_Q8NHW6	Otospiralin	89	9939	4.47	0	Secreted	NA	May be essential for the survival of the neurosensory epithelium of the inner ear.	NA	Belongs to the otospiralin family.	NA	PE2	2
+NX_Q8NHX4	Spermatogenesis-associated protein 3	192	20901	10.11	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q8NHX9	Two pore calcium channel protein 2	752	85243	6.65	12	Lysosome membrane;Nucleolus	NA	Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.	N-glycosylated.	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.	Pancreatic secretion;Stimuli-sensing channels	PE1	11
+NX_Q8NHY0	Beta-1,4 N-acetylgalactosaminyltransferase 2	566	63258	8.79	1	Golgi apparatus membrane	NA	Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain.	NA	Belongs to the glycosyltransferase 2 family.	Protein modification; protein glycosylation.;Asparagine N-linked glycosylation;Lewis blood group biosynthesis	PE1	17
+NX_Q8NHY2	E3 ubiquitin-protein ligase COP1	731	80474	6.41	0	Cytoplasm;Nucleus speckle	NA	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable).	Autoubiquitinated. MTA1 destabilizes it by promoting its autoubiquitination.	Belongs to the COP1 family.	Protein modification; protein ubiquitination.;p53 signaling pathway;Ubiquitin mediated proteolysis;Autodegradation of the E3 ubiquitin ligase COP1;Neddylation	PE1	1
+NX_Q8NHY3	GAS2-like protein 2	880	96520	9.3	0	Stress fiber;Cell membrane;Cilium basal body;Cytoskeleton	Ciliary dyskinesia, primary, 41	Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704).	NA	Belongs to the GAS2 family.	NA	PE1	17
+NX_Q8NHY5	Checkpoint protein HUS1B	278	30982	9.49	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the HUS1 family.	NA	PE1	6
+NX_Q8NHY6	Zinc finger protein 28 homolog	868	98705	9.44	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation. May have a role in embryonic development.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8NHZ7	Methyl-CpG-binding domain protein 3-like 2	208	22994	11.53	0	NA	NA	NA	NA	Belongs to the MBD3L family.	NA	PE2	19
+NX_Q8NHZ8	Anaphase-promoting complex subunit CDC26	85	9777	6.32	0	Nucleoplasm;Nucleus	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.	NA	Belongs to the CDC26 family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	9
+NX_Q8NI08	Nuclear receptor coactivator 7	942	106162	5.43	0	Golgi apparatus;Cytoplasm;Nucleus	NA	Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.	NA	Belongs to the OXR1 family.	NA	PE1	6
+NX_Q8NI17	Interleukin-31 receptor subunit alpha	732	82954	6.75	1	Presynaptic cell membrane;Cell membrane;Nucleoplasm;Cytoplasmic vesicle;Axon	Amyloidosis, primary localized cutaneous, 2	Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).	N-glycosylated.	Belongs to the type I cytokine receptor family. Type 2 subfamily.	IL-6-type cytokine receptor ligand interactions	PE1	5
+NX_Q8NI22	Multiple coagulation factor deficiency protein 2	146	16390	4.51	0	Endoplasmic reticulum;Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment	Factor V and factor VIII combined deficiency 2	The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.	NA	NA	COPII-mediated vesicle transport;Transport to the Golgi and subsequent modification;Cargo concentration in the ER	PE1	2
+NX_Q8NI27	THO complex subunit 2	1593	182775	8.67	0	Nucleoplasm;Nucleus speckle;Nucleus	Mental retardation, X-linked 12	Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development.	NA	Belongs to the THOC2 family.	RNA transport;Spliceosome;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	X
+NX_Q8NI28	Putative uncharacterized protein encoded by LINC01006	216	22304	11.7	1	Membrane	NA	NA	NA	NA	NA	PE5	7
+NX_Q8NI29	F-box only protein 27	283	31623	8.92	0	Nucleoplasm	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	19
+NX_Q8NI32	Ly6/PLAUR domain-containing protein 6B	183	20656	7.97	0	Cell membrane	NA	Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence.	NA	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	2
+NX_Q8NI35	InaD-like protein	1801	196368	4.84	0	Cell junction;Centriolar satellite;Tight junction;Apical cell membrane;Perinuclear region	NA	Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane (Probable). May regulate protein targeting, cell polarity and integrity of tight junctions (PubMed:11927608, PubMed:16678097). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950).	NA	NA	Tight junction;Tight junction interactions	PE1	1
+NX_Q8NI36	WD repeat-containing protein 36	951	105322	7.33	0	Nucleolus	Glaucoma 1, open angle, G	Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.	NA	NA	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	5
+NX_Q8NI37	Protein phosphatase PTC7 homolog	304	32646	4.99	0	Mitochondrion matrix;Cytosol;Cell membrane	NA	Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:30267671). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (PubMed:30267671).	NA	Belongs to the PP2C family.	NA	PE1	12
+NX_Q8NI38	NF-kappa-B inhibitor delta	313	33481	6.9	0	Mitochondrion;Nucleus	NA	Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes.	NA	Belongs to the NF-kappa-B inhibitor family.	NA	PE1	19
+NX_Q8NI51	Transcriptional repressor CTCFL	663	75747	8.58	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.	NA	Belongs to the CTCF zinc-finger protein family.	NA	PE1	20
+NX_Q8NI60	Atypical kinase COQ8A, mitochondrial	647	71950	6.51	1	Membrane;Mitochondrion	Coenzyme Q10 deficiency, primary, 4	Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144).	NA	Belongs to the protein kinase superfamily. ADCK protein kinase family.	Cofactor biosynthesis; ubiquinone biosynthesis.	PE1	1
+NX_Q8NI77	Kinesin-like protein KIF18A	898	102281	9.09	0	Cytoplasm;Centrosome;Ruffle;Nucleus;Cytoskeleton	NA	Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.	Ubiquitinated.;Glycosylated.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Separation of Sister Chromatids;MHC class II antigen presentation;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-dependent Golgi-to-ER retrograde traffic	PE1	11
+NX_Q8NI99	Angiopoietin-related protein 6	470	51694	8.78	0	Secreted	NA	May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.	NA	NA	NA	PE1	19
+NX_Q8TA86	Retinitis pigmentosa 9 protein	221	26107	9.8	0	Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	Retinitis pigmentosa 9	Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity).	NA	NA	NA	PE1	7
+NX_Q8TA94	Zinc finger protein 563	476	55434	9.34	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8TAA1	Probable ribonuclease 11	199	22427	6.1	0	Secreted	NA	NA	NA	Belongs to the pancreatic ribonuclease family.	NA	PE1	14
+NX_Q8TAA3	Proteasome subunit alpha-type 8	256	28530	9.07	0	Cytoplasm;Nucleus	NA	Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).	NA	Belongs to the peptidase T1A family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	18
+NX_Q8TAA5	GrpE protein homolog 2, mitochondrial	225	25431	7.63	0	Mitochondrion matrix;Mitochondrion	NA	Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).	NA	Belongs to the GrpE family.	Mitochondrial protein import	PE1	5
+NX_Q8TAA9	Vang-like protein 1	524	59975	8.94	4	Cell membrane	Neural tube defects;Sacral defect with anterior meningocele	NA	NA	Belongs to the Vang family.	Wnt signaling pathway	PE1	1
+NX_Q8TAB3	Protocadherin-19	1148	126253	5.19	1	Cytosol;Cell membrane	Epileptic encephalopathy, early infantile, 9	Potential calcium-dependent cell-adhesion protein.	NA	NA	NA	PE1	X
+NX_Q8TAB5	UPF0500 protein C1orf216	229	24968	5.17	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the UPF0500 family.	NA	PE1	1
+NX_Q8TAB7	Putative coiled-coil domain-containing protein 26	109	13192	9.51	0	NA	NA	NA	NA	NA	NA	PE5	8
+NX_Q8TAC1	Rieske domain-containing protein	157	17762	6.37	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	5
+NX_Q8TAC2	Josephin-2	188	20756	6.91	0	Cytosol	NA	Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.	NA	NA	Josephin domain DUBs	PE1	19
+NX_Q8TAC9	Secretory carrier-associated membrane protein 5	235	26104	8.8	4	Golgi apparatus;Cell membrane;trans-Golgi network membrane;Synaptic vesicle membrane;Recycling endosome membrane;Golgi apparatus membrane	NA	Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway.	NA	Belongs to the SCAMP family. SCAMP5 subfamily.	NA	PE1	15
+NX_Q8TAD2	Interleukin-17D	202	21893	9.25	0	Secreted	NA	Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.	NA	Belongs to the IL-17 family.	NA	PE1	13
+NX_Q8TAD4	Zinc transporter 5	765	84047	6.87	16	Golgi apparatus;Nucleoplasm;trans-Golgi network membrane	NA	Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.	NA	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.	Insulin processing;Zinc efflux and compartmentalization by the SLC30 family	PE1	5
+NX_Q8TAD7	Overexpressed in colon carcinoma 1 protein	63	6407	6.11	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the OCC1 family.	NA	PE1	12
+NX_Q8TAD8	Smad nuclear-interacting protein 1	396	45778	10	0	Nucleoplasm;Cytosol;Nucleus	Psychomotor retardation, epilepsy, and craniofacial dysmorphism	Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.	Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex.	NA	NA	PE1	1
+NX_Q8TAE6	Protein phosphatase 1 regulatory subunit 14C	165	17843	5.09	0	Membrane;Cytoplasm	NA	Inhibitor of the PP1 regulatory subunit PPP1CA.	Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). The main inhibitory site appears to be Thr-73.;PPP1R14C is phosphorylated by PRKACA	Belongs to the PP1 inhibitor family.	NA	PE1	6
+NX_Q8TAE7	Potassium voltage-gated channel subfamily G member 3	436	49593	8.6	6	Cytoplasm;Cytosol;Cell membrane	NA	Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).	NA	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily.	Voltage gated Potassium channels	PE1	2
+NX_Q8TAE8	Growth arrest and DNA damage-inducible proteins-interacting protein 1	222	25384	10.03	0	Mitochondrion;Nucleus	NA	Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.	NA	Belongs to the mitochondrion-specific ribosomal protein mL64 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	19
+NX_Q8TAF3	WD repeat-containing protein 48	677	76210	6.59	0	Cytoplasm;Late endosome;Lysosome;Cytoplasmic vesicle;Nucleus	NA	Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27650958, PubMed:27373336). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27650958, PubMed:27373336). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP (PubMed:12196293). In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1 (PubMed:18032488).	NA	Belongs to the WD repeat WDR48 family.	Fanconi anemia pathway;Recognition of DNA damage by PCNA-containing replication complex;Fanconi Anemia Pathway;Ub-specific processing proteases	PE1	3
+NX_Q8TAF5	Putative uncharacterized protein LQK1	88	10021	11.38	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q8TAF7	Zinc finger protein 461	563	66214	8.61	0	Golgi apparatus;Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8TAF8	LHFPL tetraspan subfamily member 5 protein	219	24201	6.69	4	Cell membrane	Deafness, autosomal recessive, 67	In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).	NA	Belongs to the LHFP family.	NA	PE1	6
+NX_Q8TAG5	V-set and transmembrane domain-containing protein 2A	236	25833	8.39	0	Secreted	NA	Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway.	N-glycosylated. N-linked glycosylation is critical for secretion but not for preadipocyte cell differentiation activity.	NA	NA	PE1	7
+NX_Q8TAG6	Vexin	207	22584	10.05	0	Cytoplasm;Nucleus speckle;Nucleus;Cell membrane	NA	Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis.	NA	Belongs to the vexin family.	NA	PE1	8
+NX_Q8TAG9	Exocyst complex component 6	804	93722	5.82	0	Cytoplasm;Growth cone;Nucleoplasm;Cytoplasmic vesicle;Perinuclear region;Midbody ring	NA	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).	NA	Belongs to the SEC15 family.	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium	PE1	10
+NX_Q8TAI1	TYMS opposite strand protein	123	13402	12.04	0	NA	NA	NA	NA	NA	NA	PE5	18
+NX_Q8TAI7	GTPase RhebL1	183	20682	6.24	0	Nucleoplasm;Endomembrane system;Cytoplasm;Centrosome	NA	Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.	NA	Belongs to the small GTPase superfamily. Rheb family.	NA	PE1	12
+NX_Q8TAK5	GA-binding protein subunit beta-2	448	48650	5.15	0	Nucleoplasm;Cytosol;Nucleus	NA	May function as transcription factor capable of interacting with purine rich repeats (GA repeats).	NA	NA	NA	PE1	1
+NX_Q8TAK6	Oligodendrocyte transcription factor 1	271	27905	9.71	0	Nucleus	NA	Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).	NA	NA	NA	PE1	21
+NX_Q8TAL5	Uncharacterized protein C9orf43	461	52222	9.01	0	Cytosol	NA	NA	NA	NA	NA	PE1	9
+NX_Q8TAL6	Fin bud initiation factor homolog	211	24273	5.3	0	Endoplasmic reticulum;Golgi apparatus;Secreted	NA	NA	NA	Belongs to the FIBIN family.	NA	PE1	11
+NX_Q8TAM1	Bardet-Biedl syndrome 10 protein	723	80838	7.95	0	Cilium	Bardet-Biedl syndrome 10	Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). Involved in adipogenic differentiation (PubMed:19190184).	NA	Belongs to the TCP-1 chaperonin family.	BBSome-mediated cargo-targeting to cilium	PE1	12
+NX_Q8TAM2	Tetratricopeptide repeat protein 8	541	61534	6.33	0	Cytoplasm;Centriolar satellite;Cilium;Centrosome;Cilium membrane	Bardet-Biedl syndrome 8;Retinitis pigmentosa 51	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.	NA	NA	BBSome-mediated cargo-targeting to cilium	PE1	14
+NX_Q8TAM6	Ermin	284	32783	4.75	0	Cytosol;Cell junction;Cytoskeleton	NA	Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).	NA	NA	NA	PE1	2
+NX_Q8TAP4	LIM domain only protein 3	145	16594	8.6	0	NA	NA	NA	NA	NA	NA	PE1	12
+NX_Q8TAP6	Centrosomal protein of 76 kDa	659	74413	6.31	0	Centrosome;Centriole	NA	Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.	NA	Belongs to the CEP76 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	18
+NX_Q8TAP8	Protein phosphatase 1 regulatory subunit 35	253	27953	8.9	0	Nucleoplasm	NA	Inhibits PPP1CA phosphatase activity.	NA	Belongs to the PPP1R35 family.	NA	PE1	7
+NX_Q8TAP9	M-phase-specific PLK1-interacting protein	179	19147	10.23	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Centrosome;Cytoplasmic vesicle;Nucleus	Trichothiodystrophy 4, non-photosensitive	May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.	Phosphorylated during mitosis in the cell cycle probably by CDK1.	NA	NA	PE1	7
+NX_Q8TAQ2	SWI/SNF complex subunit SMARCC2	1214	132879	5.49	0	Nucleoplasm;Nucleus	Coffin-Siris syndrome 8	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity).	NA	Belongs to the SMARCC family.	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	12
+NX_Q8TAQ5	Zinc finger protein 420	688	80247	8.94	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	Generic Transcription Pathway;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	PE1	19
+NX_Q8TAQ9	SUN domain-containing protein 3	357	40503	7.68	1	Membrane;Nucleus inner membrane;Golgi apparatus;Nucleus envelope	NA	As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.	NA	NA	NA	PE1	7
+NX_Q8TAS1	Serine/threonine-protein kinase Kist	419	46546	5.59	0	Nucleus;Golgi apparatus;Nucleoplasm;Midbody	NA	Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	1
+NX_Q8TAT2	Fibroblast growth factor-binding protein 3	258	27590	9.96	0	Secreted	NA	Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.	NA	Belongs to the fibroblast growth factor-binding protein family.	FGFR2b ligand binding and activation	PE1	10
+NX_Q8TAT5	Endonuclease 8-like 3	605	67769	9.23	0	Nucleoplasm;Nucleus	NA	DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.	NA	Belongs to the FPG family.	Base excision repair;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Defective Base Excision Repair Associated with NEIL3;NEIL3-mediated resolution of ICLs	PE1	4
+NX_Q8TAT6	Nuclear protein localization protein 4 homolog	608	68120	5.94	0	Nucleoplasm;Endoplasmic reticulum;Cytosol;Nucleus	NA	The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).	NA	Belongs to the NPL4 family.	Protein degradation; proteasomal ubiquitin-dependent pathway.;Protein processing in endoplasmic reticulum;Translesion Synthesis by POLH	PE1	17
+NX_Q8TAT8	Putative uncharacterized protein LOC644613	98	10982	11.47	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q8TAU0	Homeobox protein Nkx-2.3	364	38406	7.19	0	Nucleus;Cytosol;Nucleolus	NA	Transcription factor.	NA	Belongs to the NK-2 homeobox family.	NA	PE1	10
+NX_Q8TAU3	Zinc finger protein 417	575	65733	9.29	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8TAV0	Protein FAM76A	307	35049	9.33	0	NA	NA	NA	NA	Belongs to the FAM76 family.	NA	PE1	1
+NX_Q8TAV3	Cytochrome P450 2W1	490	53844	9.03	0	Endoplasmic reticulum lumen;Cell membrane	NA	Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).	NA	Belongs to the cytochrome P450 family.	Miscellaneous substrates;Xenobiotics	PE1	7
+NX_Q8TAV4	Stomatin-like protein 3	291	32135	8.83	1	Cell membrane	NA	Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.	NA	Belongs to the band 7/mec-2 family.	Stimuli-sensing channels	PE1	13
+NX_Q8TAV5	Putative uncharacterized protein C11orf45	145	15559	7.73	0	Cytosol;Secreted	NA	NA	NA	NA	NA	PE2	11
+NX_Q8TAW3	Zinc finger protein 671	534	60972	9.06	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8TAX0	Protein odd-skipped-related 1	266	29611	9.77	0	Nucleus	NA	Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.	NA	Belongs to the Odd C2H2-type zinc-finger protein family.	NA	PE1	2
+NX_Q8TAX7	Mucin-7	377	39159	8.99	0	Secreted	Asthma	May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.	N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine.	NA	Salivary secretion;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	4
+NX_Q8TAX9	Gasdermin-B	411	46786	5.15	0	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	NA	The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown (Probable).	NA	Belongs to the gasdermin family.	NA	PE1	17
+NX_Q8TAY7	Protein FAM110D	271	28710	10.08	0	NA	NA	NA	NA	Belongs to the FAM110 family.	NA	PE2	1
+NX_Q8TAZ6	CKLF-like MARVEL transmembrane domain-containing protein 2	248	27496	9.91	3	Membrane	NA	NA	NA	Belongs to the chemokine-like factor family.	NA	PE1	16
+NX_Q8TB03	Uncharacterized protein CXorf38	319	36670	5.92	0	Cytosol	NA	NA	NA	NA	NA	PE1	X
+NX_Q8TB05	UBA-like domain-containing protein 1	177	18954	6.13	0	Nucleoplasm;Cytosol;Cell junction	NA	NA	NA	Belongs to the UBALD family.	NA	PE1	16
+NX_Q8TB22	Spermatogenesis-associated protein 20	786	87899	7.08	0	Nucleoplasm;Secreted	NA	May play a role in fertility regulation.	NA	NA	NA	PE1	17
+NX_Q8TB24	Ras and Rab interactor 3	985	107854	6.17	0	Cytoplasm;Early endosome;Cytoplasmic vesicle	NA	Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.	NA	Belongs to the RIN (Ras interaction/interference) family.	RAB GEFs exchange GTP for GDP on RABs	PE1	14
+NX_Q8TB33	Putative uncharacterized protein encoded by LINC01560	94	10359	11.18	0	NA	NA	NA	NA	NA	NA	PE4	X
+NX_Q8TB36	Ganglioside-induced differentiation-associated protein 1	358	41346	8.48	2	Mitochondrion outer membrane;Cytoplasm;Cytosol;Mitochondrion	Charcot-Marie-Tooth disease, recessive, intermediate type, A;Charcot-Marie-Tooth disease 4A;Charcot-Marie-Tooth disease, axonal, with vocal cord paresis, autosomal recessive;Charcot-Marie-Tooth disease 2K	Regulates the mitochondrial network by promoting mitochondrial fission.	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	Belongs to the GST superfamily.	Class I peroxisomal membrane protein import	PE1	8
+NX_Q8TB37	Iron-sulfur protein NUBPL	319	34083	9.17	0	Mitochondrion	Mitochondrial complex I deficiency, nuclear type 21	Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits.	NA	Belongs to the Mrp/NBP35 ATP-binding proteins family.	Complex I biogenesis	PE1	14
+NX_Q8TB40	(Lyso)-N-acylphosphatidylethanolamine lipase	342	38794	7.13	0	Nucleoplasm	NA	Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.	NA	Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.	Acyl chain remodelling of PE	PE1	14
+NX_Q8TB45	DEP domain-containing mTOR-interacting protein	409	46294	8.29	0	Cytoplasm;Nucleoplasm;Mitochondrion;Nucleus	NA	Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.	Ubiquitinated; ubiquitination leads to proteasomal degradation.;Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2.	NA	NA	PE1	8
+NX_Q8TB52	F-box only protein 30	745	82304	5.21	0	Cytoskeleton	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.	Auto-ubiquitinated.;May be neddylated. Neddylation may be required for E3 ligase activity (By similarity).	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	6
+NX_Q8TB61	Adenosine 3'-phospho 5'-phosphosulfate transporter 1	432	47515	9.32	9	Cytoplasmic vesicle;Golgi apparatus membrane	NA	Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.	NA	Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.	Transport and synthesis of PAPS;Transport of nucleotide sugars	PE1	6
+NX_Q8TB68	Proline-rich protein 7	274	30930	8.91	1	Postsynaptic cell membrane;Cell membrane;Nucleoplasm;Synapse;Dendrite;Cytosol;Perinuclear region;Nucleus	NA	Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222).	Palmitoylated.;Tyrosine phosphorylated, possibly by SRC.	NA	NA	PE1	5
+NX_Q8TB69	Zinc finger protein 519	540	63020	9.48	0	Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	18
+NX_Q8TB72	Pumilio homolog 2	1066	114216	6.61	0	Cytoplasm;Cytosol;Cytoplasmic granule;Perinuclear region	NA	Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233).	NA	NA	Neddylation	PE1	2
+NX_Q8TB73	Protein NDNF	568	64673	9.07	0	Cytoplasmic vesicle;Secreted	NA	Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth and survival as well as neurite outgrowth (PubMed:20969804). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).	O-glycosylated; contains heparan sulfate and chondroitin sulfate.;N-glycosylated.	NA	NA	PE1	4
+NX_Q8TB92	3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic	370	39514	6.12	0	Cytosol;Endoplasmic reticulum membrane	NA	Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.	NA	Belongs to the HMG-CoA lyase family.	Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.;Synthesis of Ketone Bodies	PE1	6
+NX_Q8TB96	T-cell immunomodulatory protein	612	68108	5.15	1	Membrane;Cytosol;Secreted;Cytoskeleton	NA	Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).	NA	Belongs to the TIP family.	NA	PE1	16
+NX_Q8TBA6	Golgin subfamily A member 5	731	83024	5.6	1	Golgi apparatus;Golgi apparatus membrane	NA	Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.	Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase.	NA	Intra-Golgi traffic	PE1	14
+NX_Q8TBB0	THAP domain-containing protein 6	222	25691	8.99	0	Nucleoplasm;Centrosome;Nucleus	NA	NA	NA	NA	NA	PE1	4
+NX_Q8TBB1	E3 ubiquitin-protein ligase LNX	728	80629	6.67	0	Cytoplasm;Cytosol;Cell junction	NA	Provides an endocytic scaffold for IGSF5/JAM4.;E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	4
+NX_Q8TBB5	Kelch domain-containing protein 4	520	57892	5.52	0	Nucleolus	NA	NA	NA	NA	NA	PE1	16
+NX_Q8TBB6	Probable cationic amino acid transporter	771	84052	5.13	15	Cell membrane;Lysosome membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	Retinitis pigmentosa 68	May be involved in arginine transport.	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.	NA	PE1	3
+NX_Q8TBC3	SH3KBP1-binding protein 1	707	76344	8.58	0	Cell junction;Lysosome	NA	Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.	NA	Belongs to the KCTD3 family.	NA	PE1	19
+NX_Q8TBC4	NEDD8-activating enzyme E1 catalytic subunit	463	51852	5.3	0	Cell membrane;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.	NA	Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.	Protein modification; protein neddylation.;Ubiquitin mediated proteolysis;Dectin-1 mediated noncanonical NF-kB signaling;NIK-->noncanonical NF-kB signaling;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	3
+NX_Q8TBC5	Zinc finger and SCAN domain-containing protein 18	510	54804	4.76	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8TBE0	Bromo adjacent homology domain-containing 1 protein	780	84652	9.27	0	Nucleoplasm;Nucleus;Chromosome	NA	Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.	NA	NA	NA	PE1	15
+NX_Q8TBE1	Protein cornichon homolog 3	160	18976	6.17	3	Postsynaptic cell membrane	NA	Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.	NA	Belongs to the cornichon family.	COPII-mediated vesicle transport;Cargo concentration in the ER	PE2	1
+NX_Q8TBE3	Fibronectin type III domain-containing protein 9	224	25275	5.33	1	Membrane	NA	NA	NA	NA	NA	PE2	5
+NX_Q8TBE7	Solute carrier family 35 member G2	412	46422	6.99	10	Endosome;Cell membrane	NA	May play a role in cell proliferation.	NA	Belongs to the SLC35G solute transporter family.	NA	PE1	3
+NX_Q8TBE9	N-acylneuraminate-9-phosphatase	248	27813	6.01	0	Nucleus membrane	NA	NA	NA	Belongs to the HAD-like hydrolase superfamily. NANP family.	Amino-sugar metabolism; N-acetylneuraminate biosynthesis.;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Sialic acid metabolism	PE1	20
+NX_Q8TBF2	Prostamide/prostaglandin F synthase	198	21223	6.2	0	Cytosol	NA	Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).	NA	Belongs to the peroxiredoxin-like PRXL2 family. Prostamide/prostaglandin F synthase subfamily.	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	PE1	1
+NX_Q8TBF4	Zinc finger CCHC-type and RNA-binding motif-containing protein 1	217	24592	8.69	0	Nucleoplasm	NA	NA	NA	NA	mRNA Splicing - Minor Pathway	PE1	12
+NX_Q8TBF5	Phosphatidylinositol-glycan biosynthesis class X protein	258	28788	5.91	1	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane	NA	Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity).	N-glycosylated.	Belongs to the PIGX family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	3
+NX_Q8TBF8	Protein FAM81A	368	42392	8.98	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the FAM81 family.	NA	PE1	15
+NX_Q8TBG4	Ethanolamine-phosphate phospho-lyase	499	55671	8.32	0	Nucleoplasm;Mitochondrion	NA	Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.	NA	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Synthesis of PE	PE1	4
+NX_Q8TBG9	Synaptoporin	265	29166	6.07	4	Golgi apparatus;Synaptic vesicle membrane;Synaptosome;Cell membrane	NA	Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity).	NA	Belongs to the synaptophysin/synaptobrevin family.	NA	PE1	3
+NX_Q8TBH0	Arrestin domain-containing protein 2	407	44379	9.33	0	Nucleoplasm	NA	NA	NA	Belongs to the arrestin family.	NA	PE1	19
+NX_Q8TBJ4	Phospholipid phosphatase-related protein type 1	325	35795	7.04	6	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the PA-phosphatase related phosphoesterase family.	Lysosphingolipid and LPA receptors	PE1	9
+NX_Q8TBJ5	Fez family zinc finger protein 2	459	48811	9.52	0	Nucleus	NA	Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q8TBK2	N-lysine methyltransferase SETD6	473	53189	5.24	0	Nucleoplasm;Cytosol;Nucleus	NA	Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity).	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.	PKMTs methylate histone lysines	PE1	16
+NX_Q8TBK6	Zinc finger CCHC domain-containing protein 10	192	20967	8.69	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	5
+NX_Q8TBM7	Transmembrane protein 254	123	14243	9.7	3	Membrane;Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	10
+NX_Q8TBM8	DnaJ homolog subfamily B member 14	379	42516	8.79	1	Endoplasmic reticulum membrane;Nucleus membrane	NA	(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744).;Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912).	NA	Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.	NA	PE1	4
+NX_Q8TBN0	Guanine nucleotide exchange factor for Rab-3A	382	42637	6.07	0	Cytosol;Centriolar satellite	NA	Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B.	NA	Belongs to the SEC2 family.	RAB GEFs exchange GTP for GDP on RABs	PE1	11
+NX_Q8TBP0	TBC1 domain family member 16	767	86372	5.55	0	Cytoskeleton	NA	May act as a GTPase-activating protein for Rab family protein(s).	NA	NA	TBC/RABGAPs	PE1	17
+NX_Q8TBP5	Membrane protein FAM174A	190	19954	5.92	1	Membrane;Golgi apparatus;Cytosol	NA	NA	NA	Belongs to the FAM174 family.	NA	PE1	5
+NX_Q8TBP6	Solute carrier family 25 member 40	338	38125	9.43	6	Mitochondrion inner membrane	NA	NA	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	7
+NX_Q8TBQ9	Protein kish-A	72	8060	9.26	1	Cytoplasmic vesicle;Golgi apparatus membrane	NA	Involved in the early part of the secretory pathway.	NA	Belongs to the KISH family.	NA	PE1	5
+NX_Q8TBR4	Putative STAG3-like protein 4	150	17020	5.92	0	NA	NA	NA	NA	Belongs to the SCC3 family.	NA	PE5	7
+NX_Q8TBR5	Putative uncharacterized protein CIRBP-AS1	109	12399	12.01	0	NA	NA	NA	NA	NA	NA	PE5	19
+NX_Q8TBR7	TLC domain-containing protein 3A	257	29383	9.57	7	Cell membrane	NA	NA	NA	NA	NA	PE1	17
+NX_Q8TBX8	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	421	47300	6.36	0	Membrane;Cytoplasmic vesicle;Cytoplasm	NA	May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.	NA	NA	Inositol phosphate metabolism;Phosphatidylinositol signaling system;Regulation of actin cytoskeleton;Synthesis of PIPs at the plasma membrane;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PI5P Regulates TP53 Acetylation;Synthesis of PIPs in the nucleus	PE1	12
+NX_Q8TBY0	Probable RNA-binding protein 46	533	60023	7.56	0	NA	NA	NA	NA	NA	NA	PE1	4
+NX_Q8TBY8	Polyamine-modulated factor 1-binding protein 1	1007	117494	5.94	0	Endoplasmic reticulum;Flagellum	Spermatogenic failure 31	Required for normal spermatogenesis (PubMed:1770140, PubMed:30032984, PubMed:30298696). It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity (PubMed:30032984). May also be involved in the general organization of cellular cytoskeleton (By similarity).	NA	NA	NA	PE1	16
+NX_Q8TBY9	Cilia- and flagella-associated protein 251	1149	129952	4.99	0	Golgi apparatus;Cell membrane;Cilium axoneme;Flagellum;Cytosol	Spermatogenic failure 33	Involved in spermatozoa motility (PubMed:30122540, PubMed:30122541). May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).	NA	NA	NA	PE1	12
+NX_Q8TBZ0	Coiled-coil domain-containing protein 110	833	96726	5.88	0	Nucleus	NA	NA	NA	NA	NA	PE1	4
+NX_Q8TBZ2	MYCBP-associated protein	947	108153	7.13	0	Membrane;Cytoplasm;Cytoplasmic vesicle	NA	May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).	NA	NA	NA	PE1	17
+NX_Q8TBZ3	WD repeat-containing protein 20	569	62893	8.26	0	NA	NA	Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336).	NA	NA	Ub-specific processing proteases	PE1	14
+NX_Q8TBZ5	Zinc finger protein 502	544	62920	9.02	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q8TBZ6	tRNA methyltransferase 10 homolog A	339	39719	7.29	0	Nucleolus;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Microcephaly, short stature, and impaired glucose metabolism 1	S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).	NA	Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.	tRNA modification in the nucleus and cytosol	PE1	4
+NX_Q8TBZ8	Zinc finger protein 564	553	63735	8.99	0	Golgi apparatus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8TBZ9	Testis-expressed protein 47	253	29483	7.21	0	Nucleoplasm;Mitochondrion	NA	NA	NA	NA	NA	PE1	7
+NX_Q8TC05	Nuclear protein MDM1	714	80735	9.16	0	Cytosol;Centrosome;Nucleus;Centriole	NA	Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392).	NA	Belongs to the MDM1 family.	NA	PE1	12
+NX_Q8TC07	TBC1 domain family member 15	691	79491	5.44	0	Cytoplasm;Cytosol;Mitochondrion	NA	Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).	NA	NA	TBC/RABGAPs	PE1	12
+NX_Q8TC12	Retinol dehydrogenase 11	318	35386	9.05	1	Endoplasmic reticulum membrane	Retinal dystrophy, juvenile cataracts, and short stature syndrome	Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956).	Not glycosylated.	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Cofactor metabolism; retinol metabolism.;Retinol metabolism;Metabolic pathways;The canonical retinoid cycle in rods (twilight vision);RA biosynthesis pathway;Retinoid metabolism and transport	PE1	14
+NX_Q8TC17	GRB2-related adapter protein-like	118	13442	7.89	0	NA	NA	NA	NA	Belongs to the GRB2/sem-5/DRK family.	NA	PE2	17
+NX_Q8TC20	Cancer-associated gene 1 protein	777	90250	5.21	0	NA	NA	NA	NA	NA	NA	PE1	6
+NX_Q8TC21	Zinc finger protein 596	504	58513	9.19	0	Nucleolus;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	8
+NX_Q8TC26	Transmembrane protein 163	289	31469	7.06	6	Early endosome membrane;Synaptic vesicle membrane	NA	May bind zinc and other divalent cations and recruit them to vesicular organelles.	NA	Belongs to the TMEM163 family.	NA	PE1	2
+NX_Q8TC27	Disintegrin and metalloproteinase domain-containing protein 32	787	87948	5.39	1	Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.	NA	NA	NA	PE1	8
+NX_Q8TC29	Enkurin	256	29454	9.34	0	Flagellum	NA	Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.	NA	NA	NA	PE1	10
+NX_Q8TC36	SUN domain-containing protein 5	379	43081	8.61	1	Golgi apparatus;Nucleus inner membrane	Spermatogenic failure 16	Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope.	Highly glycosylated in the Golgi apparatus during spermiogenesis.	NA	NA	PE1	20
+NX_Q8TC41	Probable E3 ubiquitin-protein ligase RNF217	542	59372	7.65	1	Membrane	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	NA	Belongs to the RBR family. RNF217 subfamily.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	6
+NX_Q8TC44	POC1 centriolar protein homolog B	478	53668	6.79	0	Spindle pole;Centrosome;Cilium basal body;Centriole	Cone-rod dystrophy 20	Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745).	Phosphorylated in mitotic cells that may be mediated by CDK1.	Belongs to the WD repeat POC1 family.	NA	PE1	12
+NX_Q8TC56	Protein FAM71B	605	64756	9.52	0	Nucleus	NA	May be involved in RNA biogenesis.	NA	Belongs to the FAM71 family.	NA	PE1	5
+NX_Q8TC57	Meiosis 1 arrest protein	530	59386	6.4	0	Cytoplasm;Mitochondrion;Nucleolus	NA	Required for meiosis I progression during spermatogenesis.	NA	NA	NA	PE1	2
+NX_Q8TC59	Piwi-like protein 2	973	109849	9.16	0	Cytoplasm	NA	Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660). Represses circadian rhythms by promoting the stability and activity of core clock components ARNTL/BMAL1 and CLOCK by inhibiting GSK3B-mediated phosphorylation and ubiquitination-dependent degradation of these proteins (PubMed:28903391).	Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein TDRD1 and subsequent localization to the meiotic nuage, also named P granule.	Belongs to the argonaute family. Piwi subfamily.	Dorso-ventral axis formation;PIWI-interacting RNA (piRNA) biogenesis	PE1	8
+NX_Q8TC71	Mitochondria-eating protein	538	61109	8.93	0	Mitochondrion outer membrane;Cytoplasm;Mitochondrion	NA	Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.	NA	Belongs to the MIEAP family.	NA	PE1	4
+NX_Q8TC76	Protein FAM110B	370	40728	9.45	0	Cytoplasm;Cytosol;Mitochondrion;Centrosome	NA	May be involved in tumor progression.	NA	Belongs to the FAM110 family.	NA	PE1	8
+NX_Q8TC84	Fibronectin type 3 and ankyrin repeat domains protein 1	345	38341	8.93	0	Cilium;Cilium basal body;Nucleoplasm;Cytosol;Nucleus	NA	Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.	Polyubiquitinated. Polyubiquitination leads to proteasomal degradation.	NA	NA	PE1	10
+NX_Q8TC90	Coiled-coil domain-containing glutamate-rich protein 1	406	46482	4.64	0	NA	NA	NA	NA	NA	NA	PE1	12
+NX_Q8TC92	Ecto-NOX disulfide-thiol exchanger 1	643	73348	5.4	0	Cell membrane;Extracellular space	NA	Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.	NA	Belongs to the ENOX family.	NA	PE1	13
+NX_Q8TC94	Actin-like protein 9	416	45627	6.61	0	Cytoskeleton	NA	NA	NA	Belongs to the actin family.	NA	PE1	19
+NX_Q8TC99	Fibronectin type III domain-containing protein 8	324	35921	5.01	0	NA	NA	NA	NA	NA	NA	PE1	17
+NX_Q8TCA0	Leucine-rich repeat-containing protein 20	184	20509	6.11	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	10
+NX_Q8TCB0	Interferon-induced protein 44	444	50491	6.44	0	Cytoplasm;Nucleoplasm	NA	This protein aggregates to form microtubular structures.	NA	Belongs to the IFI44 family.	NA	PE1	1
+NX_Q8TCB6	Olfactory receptor 51E1	317	35271	8.71	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8TCB7	tRNA N(3)-methylcytidine methyltransferase METTL6	284	33251	5.85	0	Cytoplasmic vesicle	NA	S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser).	NA	Belongs to the methyltransferase superfamily. METL family.	Histidine metabolism;Tyrosine metabolism	PE1	3
+NX_Q8TCC3	39S ribosomal protein L30, mitochondrial	161	18546	10.01	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL30 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	2
+NX_Q8TCC7	Solute carrier family 22 member 8	542	59856	9.07	11	Basolateral cell membrane	NA	Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Bile secretion;Organic anion transport	PE1	11
+NX_Q8TCD1	UPF0729 protein C18orf32	76	8669	9.24	0	Cytoplasmic vesicle;Nucleoplasm	NA	May activate the NF-kappa-B signaling pathway.	NA	Belongs to the UPF0729 family.	NA	PE1	18
+NX_Q8TCD5	5'(3')-deoxyribonucleotidase, cytosolic type	201	23383	6.18	0	Cytoplasm;Cytosol	NA	Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.	NA	Belongs to the 5'(3')-deoxyribonucleotidase family.	Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Pyrimidine catabolism;Purine catabolism	PE1	17
+NX_Q8TCD6	Pyridoxal phosphate phosphatase PHOSPHO2	241	27769	6.31	0	Cytoplasmic vesicle	NA	Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.	NA	Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.	Vitamin B6 metabolism;Metabolic pathways	PE1	2
+NX_Q8TCE6	DENN domain-containing protein 10	357	40513	6.15	0	Late endosome	NA	Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form.	NA	Belongs to the DENND10 family.	NA	PE1	10
+NX_Q8TCE9	Placental protein 13-like	139	16094	6.4	0	Nucleoplasm;Nucleus	NA	Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.	NA	NA	NA	PE1	19
+NX_Q8TCF1	AN1-type zinc finger protein 1	268	30787	7.14	0	Cytosol;Stress granule;Centrosome	NA	Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830).	NA	NA	NA	PE1	8
+NX_Q8TCG1	Protein CIP2A	905	102185	5.85	1	Membrane;Cytoplasm;Cytosol;Cell membrane	NA	Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.	NA	NA	NA	PE1	3
+NX_Q8TCG2	Phosphatidylinositol 4-kinase type 2-beta	481	54744	5.71	0	Membrane;Cytoplasm;Cytosol	NA	Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.	NA	Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the ER membrane;Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane	PE1	4
+NX_Q8TCG5	Carnitine O-palmitoyltransferase 1, brain isoform	803	90989	8.33	2	Mitochondrion outer membrane;Endoplasmic reticulum;Centrosome;Synapse;Axon;Dendrite	Spastic paraplegia 73, autosomal dominant	May play a role in lipid metabolic process.	NA	Belongs to the carnitine/choline acetyltransferase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid metabolism;PPAR signaling pathway;Adipocytokine signaling pathway	PE1	19
+NX_Q8TCH9	Putative uncharacterized protein FLJ23865	128	14227	7.15	0	NA	NA	NA	NA	NA	NA	PE2	22
+NX_Q8TCI5	Protein pitchfork	191	21973	9.91	0	trans-Golgi network;Cytoplasmic vesicle;Cytoplasm	NA	During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner.	NA	NA	NA	PE1	1
+NX_Q8TCJ0	F-box only protein 25	367	43313	8.35	0	Nucleus	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).	NA	NA	Protein modification; protein ubiquitination.	PE1	8
+NX_Q8TCJ2	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B	826	93674	9.04	13	Endoplasmic reticulum;Endoplasmic reticulum membrane	Congenital disorder of glycosylation 1X	Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation (PubMed:19167329, PubMed:22607976).	NA	Belongs to the STT3 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum	PE1	3
+NX_Q8TCN5	Zinc finger protein 507	953	105767	5.47	0	Nucleolus;Nucleus;Cytosol	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8TCP9	Protein FAM200A	573	66276	5.82	1	Membrane	NA	NA	NA	Belongs to the FAM200 family.	NA	PE1	7
+NX_Q8TCQ1	E3 ubiquitin-protein ligase MARCH1	289	32308	8.76	2	Mitochondrion;Cell membrane;Lysosome membrane;trans-Golgi network membrane;Cytoplasmic vesicle membrane;Early endosome membrane;Late endosome membrane	NA	E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.	Has a short half-life. Instability/short half-life permits rapid changes that allow efficient induction of antigen presentation once antigen presenting cells, APCs, receive maturation signals. Small changes in protein levels significantly alter the cell surface display of MHC class II proteins (By similarity).	NA	Protein modification; protein ubiquitination.	PE1	4
+NX_Q8TCS8	Polyribonucleotide nucleotidyltransferase 1, mitochondrial	783	85951	7.87	0	Cytoplasm;Mitochondrion matrix;Mitochondrion intermembrane space;Mitochondrion	Deafness, autosomal recessive, 70;Combined oxidative phosphorylation deficiency 13	RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.	NA	Belongs to the polyribonucleotide nucleotidyltransferase family.	Purine metabolism;Pyrimidine metabolism;RNA degradation	PE1	2
+NX_Q8TCT0	Ceramide kinase	537	59977	8.54	0	Cytoplasmic vesicle;Cytoplasm;Cell membrane	NA	Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031).	NA	NA	Sphingolipid metabolism;Glycosphingolipid metabolism	PE1	22
+NX_Q8TCT1	Phosphoethanolamine/phosphocholine phosphatase	267	29713	7.64	0	Cell membrane;Cytoskeleton	NA	Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.	NA	Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.	Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PC;Synthesis of PE	PE1	17
+NX_Q8TCT6	Signal peptide peptidase-like 3	384	42261	8.64	9	Golgi apparatus;Endoplasmic reticulum membrane;Cell membrane;Membrane;Cytoplasmic vesicle	NA	Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).	Not glycosylated (PubMed:15385547, PubMed:15998642).	Belongs to the peptidase A22B family.	NA	PE1	12
+NX_Q8TCT7	Signal peptide peptidase-like 2B	592	64644	8.67	9	Cell membrane;Endosome membrane;Lysosome membrane;Membrane;Nucleoplasm;Centrosome;Golgi apparatus membrane	NA	Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).	Glycosylated (PubMed:15385547, PubMed:15998642).	Belongs to the peptidase A22B family.	Regulation of TNFR1 signaling	PE1	19
+NX_Q8TCT8	Signal peptide peptidase-like 2A	520	58143	8.65	9	Membrane;Cytoplasmic vesicle;Lysosome membrane;Late endosome membrane	NA	Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).	Glycosylated.	Belongs to the peptidase A22B family.	Regulation of TNFR1 signaling	PE1	15
+NX_Q8TCT9	Minor histocompatibility antigen H13	377	41488	6	9	Membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane;Cell membrane	NA	Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity).	N-glycosylated.	Belongs to the peptidase A22B family.	NA	PE1	20
+NX_Q8TCU3	Solute carrier family 7 member 13	470	52114	9.08	12	Membrane	NA	Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily.	NA	PE2	8
+NX_Q8TCU4	Alstrom syndrome protein 1	4168	461062	5.87	0	Cytoplasm;Cilium basal body;Nucleoplasm;Spindle pole;Centrosome;Cytosol	Alstrom syndrome	Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells.	NA	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	2
+NX_Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	1115	125465	7.4	3	Postsynaptic cell membrane;Postsynaptic density;Cell membrane	NA	NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).	N-glycosylated.	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily.	Neuroactive ligand-receptor interaction;Glutamatergic synapse;Assembly and cell surface presentation of NMDA receptors	PE1	9
+NX_Q8TCU6	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein	1659	186203	6.03	0	Cytoplasmic vesicle;Cytosol;Cytoplasm;Cell membrane	NA	Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.	NA	NA	Chemokine signaling pathway;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	20
+NX_Q8TCV5	WAP four-disulfide core domain protein 5	224	24238	8.4	0	Secreted	NA	Putative acid-stable proteinase inhibitor.	NA	NA	NA	PE1	20
+NX_Q8TCW7	Zona pellucida-like domain-containing protein 1	415	45530	7.92	1	Nucleoplasm;Extracellular matrix;Cytoplasmic vesicle membrane	NA	Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ.	Proteolytically cleaved before the transmembrane segment to yield the secreted form found in the extracellular matrix of the cupula.	NA	NA	PE1	3
+NX_Q8TCW9	Prokineticin receptor 1	393	44770	8.68	7	Cell membrane	NA	Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.	NA	Belongs to the G-protein coupled receptor 1 family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	2
+NX_Q8TCX1	Cytoplasmic dynein 2 light intermediate chain 1	351	39625	7.1	0	Cytoplasm;Cilium;Cilium basal body;Centrosome;Cilium axoneme;Cytosol	Short-rib thoracic dysplasia 15 with polydactyly	Required for correct intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length.	NA	Belongs to the dynein light intermediate chain family.	Vasopressin-regulated water reabsorption;Intraflagellar transport	PE1	2
+NX_Q8TCX5	Rhophilin-1	670	73590	7.3	0	Nucleoplasm	NA	Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules.	NA	Belongs to the RHPN family.	RHO GTPases Activate Rhotekin and Rhophilins	PE1	8
+NX_Q8TCY0	Small integral membrane protein 11B	68	7880	9.49	1	Membrane	NA	NA	NA	Belongs to the SMIM11 family.	NA	PE2	21
+NX_Q8TCY5	Melanocortin-2 receptor accessory protein	172	19136	7.75	1	Endoplasmic reticulum membrane;Cell membrane	Glucocorticoid deficiency 2	Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.	NA	Belongs to the MRAP family.	NA	PE1	21
+NX_Q8TCY9	Up-regulator of cell proliferation	931	104987	6	0	Cytoplasm;Cytosol;Nucleus	NA	May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.	NA	PE1	7
+NX_Q8TCZ2	CD99 antigen-like protein 2	262	27986	4.92	1	Golgi apparatus;Cell junction;Cell membrane	NA	Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).	O-glycosylated.	Belongs to the CD99 family.	Cell surface interactions at the vascular wall	PE1	X
+NX_Q8TCZ7	Putative uncharacterized protein encoded by LINC00308	52	5991	8.8	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_Q8TD06	Anterior gradient protein 3	166	19171	7.76	0	Endoplasmic reticulum;Cytoplasmic vesicle	NA	Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.	NA	Belongs to the AGR family.	NA	PE1	7
+NX_Q8TD07	Retinoic acid early transcript 1E	263	30122	8.45	1	Membrane;Cytosol;Focal adhesion;Secreted	NA	Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.	NA	Belongs to the MHC class I family.	Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	6
+NX_Q8TD08	Mitogen-activated protein kinase 15	544	59832	9.17	0	Cytoplasm;Golgi apparatus;Centriole;Cell junction;Cilium basal body;Nucleoplasm;Tight junction;Autophagosome;Cytosol;Spindle;Nucleus	NA	Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:20638370, PubMed:19166846). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936).	Ubiquitinated (PubMed:19166846). Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase (By similarity).;Autophosphorylated on Thr-175 and Tyr-177; activates the enzyme.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	NA	PE1	8
+NX_Q8TD10	Mirror-image polydactyly gene 1 protein	442	51537	5.55	0	Cytosol	NA	NA	NA	NA	NA	PE1	14
+NX_Q8TD16	Protein bicaudal D homolog 2	824	93533	5.35	0	Golgi apparatus;Cytoplasm;Nuclear pore complex;Cell membrane;Nucleus envelope;Cytosol;Cytoskeleton	Spinal muscular atrophy, lower extremity-predominant 2A, childhood onset, autosomal dominant;Spinal muscular atrophy, lower extremity-predominant, 2B, prenatal onset, autosomal dominant	Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity).	Phosphorylated by NEK9 in vitro.	Belongs to the BicD family.	COPI-independent Golgi-to-ER retrograde traffic	PE1	9
+NX_Q8TD17	Zinc finger protein 398	642	71311	6.2	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Function as a transcriptional activator.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q8TD19	Serine/threonine-protein kinase Nek9	979	107168	5.51	0	Cytoplasm;Mitochondrion;Nucleus	Arthrogryposis, Perthes disease, and upward gaze palsy;Nevus comedonicus;Lethal congenital contracture syndrome 10	Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.	Autophosphorylated on serine and threonine residues (PubMed:27153399). When complexed with FACT, exhibits markedly elevated phosphorylation on Thr-210. During mitosis, not phosphorylated on Thr-210. Phosphorylated by CDK1 in vitro.;NEK9 is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	Nuclear Pore Complex (NPC) Disassembly;Activation of NIMA Kinases NEK9, NEK6, NEK7	PE1	14
+NX_Q8TD20	Solute carrier family 2, facilitated glucose transporter member 12	617	66966	8.66	12	Endomembrane system;Cell junction;Perinuclear region;Cell membrane	NA	Insulin-independent facilitative glucose transporter.	NA	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Cellular hexose transport	PE1	6
+NX_Q8TD22	Sideroflexin-5	340	37124	9.4	4	Mitochondrion membrane;Nucleoplasm;Mitochondrion	NA	Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (PubMed:30442778). Transports citrate (By similarity).	NA	Belongs to the sideroflexin family.	NA	PE1	2
+NX_Q8TD23	Zinc finger protein 675	568	66299	9.11	0	Nucleus	NA	May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.	NA	NA	Generic Transcription Pathway	PE1	19
+NX_Q8TD26	Chromodomain-helicase-DNA-binding protein 6	2715	305412	5.9	0	Nucleoplasm	NA	DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.;(Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner.	NA	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	20
+NX_Q8TD30	Alanine aminotransferase 2	523	57904	7.85	0	Mitochondrion	Mental retardation, autosomal recessive 49	Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.	NA	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.	Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.;Alanine, aspartate and glutamate metabolism;Metabolic pathways;Alanine metabolism	PE1	16
+NX_Q8TD31	Coiled-coil alpha-helical rod protein 1	782	88671	5.76	0	Cytoplasm;Cytosol;Nucleus	NA	May be a regulator of keratinocyte proliferation or differentiation.	NA	NA	NA	PE1	6
+NX_Q8TD33	Secretoglobin family 1C member 1	95	10414	4.55	0	Secreted	NA	NA	NA	Belongs to the secretoglobin family.	NA	PE2	11
+NX_Q8TD35	Protein LKAAEAR1	194	21508	10.61	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	20
+NX_Q8TD43	Transient receptor potential cation channel subfamily M member 4	1214	134301	8.49	6	Golgi apparatus;Endoplasmic reticulum;Nucleoplasm;Cell membrane	Progressive familial heart block 1B	Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.	Sumoylated. Desumoylated by SENP1.;Phosphorylation by PKC leads to increase the sensitivity to Ca(2+).	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily.	TRP channels	PE1	19
+NX_Q8TD46	Cell surface glycoprotein CD200 receptor 1	325	36620	8.19	1	Secreted;Cell membrane	NA	Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.	The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.	Belongs to the CD200R family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	3
+NX_Q8TD47	40S ribosomal protein S4, Y isoform 2	263	29295	10.1	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eS4 family.	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE2	Y
+NX_Q8TD55	Pleckstrin homology domain-containing family O member 2	490	53350	5.34	0	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	NA	Cytokine-cytokine receptor interaction;Neutrophil degranulation	PE1	15
+NX_Q8TD57	Dynein heavy chain 3, axonemal	4116	470771	6.04	0	Cilium axoneme;Nucleus membrane;Cytoskeleton	NA	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).	NA	Belongs to the dynein heavy chain family.	Huntington's disease	PE1	16
+NX_Q8TD84	Down syndrome cell adhesion molecule-like protein 1	2053	224463	8.43	1	Synapse;Cell membrane	NA	Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).	NA	NA	DSCAM interactions	PE1	11
+NX_Q8TD86	Calmodulin-like protein 6	181	20690	4.47	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the calmodulin family. Calglandulin subfamily.	Calcium signaling pathway;Phosphatidylinositol signaling system;Oocyte meiosis;Vascular smooth muscle contraction;Long-term potentiation;Neurotrophin signaling pathway;Dopaminergic synapse;Olfactory transduction;Phototransduction;Insulin signaling pathway;GnRH signaling pathway;Melanogenesis;Salivary secretion;Gastric acid secretion;Alzheimer's disease;Pertussis;Tuberculosis;Glioma	PE2	1
+NX_Q8TD90	Melanoma-associated antigen E2	523	60378	5	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_Q8TD91	Melanoma-associated antigen C3	643	71909	4.77	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_Q8TD94	Krueppel-like factor 14	323	33094	8.26	0	Nucleus	NA	NA	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE2	7
+NX_Q8TDB4	Protein MGARP	240	25390	4.4	1	Mitochondrion outer membrane;Mitochondrion	NA	Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity).	NA	NA	NA	PE1	4
+NX_Q8TDB6	E3 ubiquitin-protein ligase DTX3L	740	83554	8.31	0	Cytoplasm;Lysosome membrane;Nucleoplasm;Early endosome membrane;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B HIST1H2BH/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788).	Autoubiquitinated.	Belongs to the Deltex family.	Protein modification; protein ubiquitination.;Notch signaling pathway;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	3
+NX_Q8TDB8	Solute carrier family 2, facilitated glucose transporter member 14	520	56320	8	12	Cell membrane	NA	Hexose transporter that can mediate the transport of glucose and dehydroascorbate across the cell membrane.	NA	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Cellular hexose transport	PE1	12
+NX_Q8TDC0	Myozenin-3	251	27157	9.42	0	Z line	NA	Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.	NA	Belongs to the myozenin family.	NA	PE1	5
+NX_Q8TDC3	Serine/threonine-protein kinase BRSK1	778	85087	9.39	0	Cytoplasm;Presynaptic active zone;Nucleoplasm;Centrosome;Synapse;Synaptic vesicle;Nucleus	NA	Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.	Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C.;BRSK1 is phosphorylated by CAMKK2	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	NA	PE1	19
+NX_Q8TDD1	ATP-dependent RNA helicase DDX54	881	98595	10.03	0	Golgi apparatus;Nucleoplasm;Nucleolus	NA	Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.	NA	Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	NA	PE1	12
+NX_Q8TDD2	Transcription factor Sp7	431	44994	8.67	0	Nucleus	Osteogenesis imperfecta 12	Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).;Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences.	Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours.	Belongs to the Sp1 C2H2-type zinc-finger protein family.	RUNX2 regulates osteoblast differentiation	PE1	12
+NX_Q8TDD5	Mucolipin-3	553	64248	5.8	6	Autophagosome membrane;Cell membrane;Lysosome membrane;Nucleolus;Early endosome membrane;Cytosol;Late endosome membrane	NA	Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151).	N-glycosylated.	Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN3 sub-subfamily.	TRP channels	PE1	1
+NX_Q8TDE3	Ribonuclease 8	154	17041	8.69	0	Secreted	NA	Has a low ribonuclease activity.	NA	Belongs to the pancreatic ribonuclease family.	Antimicrobial peptides	PE1	14
+NX_Q8TDF5	Neuropilin and tolloid-like protein 1	533	60191	6.61	1	Golgi apparatus;Secreted;Postsynaptic density;Cell membrane	NA	Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).	NA	NA	NA	PE1	18
+NX_Q8TDF6	RAS guanyl-releasing protein 4	673	74882	8.34	0	Nucleoplasm;Cytoplasm;Cytosol;Cell membrane	NA	Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.	NA	Belongs to the RASGRP family.	MAPK signaling pathway;FCERI mediated NF-kB activation;RAF/MAP kinase cascade	PE1	19
+NX_Q8TDG2	Actin-related protein T1	376	41696	6.32	0	Cytoplasm;Nucleus;Cytoskeleton	NA	Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.	NA	Belongs to the actin family.	NA	PE2	X
+NX_Q8TDG4	Helicase POLQ-like	1101	124131	6.17	0	Nucleoplasm;Nucleus speckle	NA	Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase (PubMed:11751861). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904).	NA	Belongs to the helicase family. SKI2 subfamily.	NA	PE1	4
+NX_Q8TDH9	Biogenesis of lysosome-related organelles complex 1 subunit 5	187	21609	7.14	0	Cytoplasmic vesicle	NA	Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.	NA	Belongs to the BLOC1S5 family.	NA	PE1	6
+NX_Q8TDI0	Chromodomain-helicase-DNA-binding protein 5	1954	223050	5.82	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.	Methylated at Gln-1390 by N6AMT1.	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	1
+NX_Q8TDI7	Transmembrane channel-like protein 2	906	102610	9.5	6	Cell membrane	NA	Probable ion channel required for the normal function of cochlear hair cells (PubMed:11850618). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity).	NA	Belongs to the TMC family.	NA	PE2	20
+NX_Q8TDI8	Transmembrane channel-like protein 1	760	87768	6.22	6	Cell membrane	Deafness, autosomal recessive, 7;Deafness, autosomal dominant, 36	Probable ion channel required for the normal function of cochlear hair cells.	NA	Belongs to the TMC family.	NA	PE1	9
+NX_Q8TDJ6	DmX-like protein 2	3036	339641	5.93	0	Synaptic vesicle membrane	Polyendocrine-polyneuropathy syndrome;Deafness, autosomal dominant, 71	May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).	NA	NA	NA	PE1	15
+NX_Q8TDL5	BPI fold-containing family B member 1	484	52442	6.72	0	Secreted	NA	May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.	NA	Belongs to the BPI/LBP/Plunc superfamily. Plunc family.	Antimicrobial peptides	PE1	20
+NX_Q8TDM0	Breast carcinoma-amplified sequence 4	211	22758	5.59	0	Cytoplasm;Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the cappuccino family.	NA	PE1	20
+NX_Q8TDM5	Sperm acrosome membrane-associated protein 4	124	13004	5.49	0	Cell membrane;Acrosome	NA	Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.	NA	Belongs to the SPACA4/bouncer family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	19
+NX_Q8TDM6	Disks large homolog 5	1919	213868	7.1	0	Cell junction;Postsynaptic density;Cilium basal body;Cell membrane	NA	Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).	NA	Belongs to the MAGUK family.	NA	PE1	10
+NX_Q8TDN1	Potassium voltage-gated channel subfamily G member 4	519	58979	6.23	6	Cell membrane	NA	Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).	NA	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily.	Voltage gated Potassium channels	PE1	16
+NX_Q8TDN2	Potassium voltage-gated channel subfamily V member 2	545	62459	6.08	6	Cell membrane	Cone dystrophy retinal 3B	Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.	NA	Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily.	Voltage gated Potassium channels	PE1	9
+NX_Q8TDN4	CDK5 and ABL1 enzyme substrate 1	633	67599	9.32	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).	Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 (By similarity).;CABLES1 is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255);CABLES1 is phosphorylated by CDK3	Belongs to the cyclin family.	Factors involved in megakaryocyte development and platelet production;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry	PE1	18
+NX_Q8TDN6	Ribosome biogenesis protein BRX1 homolog	353	41401	9.92	0	Nucleoplasm;Nucleolus;Nucleus	NA	Required for biogenesis of the 60S ribosomal subunit.	NA	Belongs to the BRX1 family.	NA	PE1	5
+NX_Q8TDN7	Alkaline ceramidase 1	264	31095	6.64	7	Endoplasmic reticulum membrane	NA	Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:17713573, PubMed:20207939, PubMed:20628055). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875). Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:17713573, PubMed:20207939). May also hydrolyze dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:17713573).	NA	Belongs to the alkaline ceramidase family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis	PE1	19
+NX_Q8TDP1	Ribonuclease H2 subunit C	164	17840	4.95	0	Nucleoplasm;Nucleus	Aicardi-Goutieres syndrome 3	Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.	NA	Belongs to the RNase H2 subunit C family.	DNA replication	PE1	11
+NX_Q8TDQ0	Hepatitis A virus cellular receptor 2	301	33394	5.54	1	Membrane;Cell junction;Cell membrane	T-cell lymphoma, subcutaneous panniculitis-like	Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity).	O-glycosylated with core 1 or possibly core 8 glycans.;Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation. Can be phosphorylated in the cytoplasmatic domain by FYN (By similarity). Phosphorylation at Tyr-265 is increased by stimulation with ligand LGALS9.	Belongs to the immunoglobulin superfamily. TIM family.	Interleukin-2 family signaling	PE1	5
+NX_Q8TDQ1	CMRF35-like molecule 1	290	32335	5.45	1	Cell membrane	NA	Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).	Phosphorylated on tyrosine.	Belongs to the CD300 family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	17
+NX_Q8TDQ7	Glucosamine-6-phosphate isomerase 2	276	31085	6.45	0	Cytoplasm	NA	NA	NA	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.	Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Glycolysis	PE1	4
+NX_Q8TDR0	TRAF3-interacting protein 1	691	78632	7.95	0	Cilium axoneme;Cilium;Cilium basal body;Cytoskeleton	Senior-Loken syndrome 9	Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity).	NA	Belongs to the TRAF3IP1 family.	Intraflagellar transport	PE1	2
+NX_Q8TDR2	Serine/threonine-protein kinase 35	534	58051	9.78	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	NA	Autophosphorylated.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	20
+NX_Q8TDR4	T-complex protein 10A homolog 1	215	23863	9.71	0	Nucleus	NA	May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.	NA	Belongs to the TCP10 family.	NA	PE1	21
+NX_Q8TDS4	Hydroxycarboxylic acid receptor 2	363	41850	9.34	7	Cell membrane	NA	Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Hydroxycarboxylic acid-binding receptors;Class A/1 (Rhodopsin-like receptors)	PE1	12
+NX_Q8TDS5	Oxoeicosanoid receptor 1	423	45811	9.75	7	Cell membrane	NA	Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Eicosanoid ligand-binding receptors	PE1	2
+NX_Q8TDS7	Mas-related G-protein coupled receptor member D	321	36118	9.25	7	Cell membrane	NA	May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).	NA	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.	NA	PE2	11
+NX_Q8TDT2	Probable G-protein coupled receptor 152	470	50962	4.59	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	11
+NX_Q8TDU5	Putative vomeronasal receptor-like protein 4	208	23857	9.14	5	Cell membrane	NA	Putative pheromone receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE5	1
+NX_Q8TDU6	G-protein coupled bile acid receptor 1	330	35248	9.62	7	Cell membrane	NA	Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.	NA	Belongs to the G-protein coupled receptor 1 family.	Class A/1 (Rhodopsin-like receptors);G alpha (s) signalling events	PE1	2
+NX_Q8TDU9	Relaxin-3 receptor 2	374	41141	10.32	7	Cell membrane	NA	High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Relaxin receptors	PE1	1
+NX_Q8TDV0	G-protein coupled receptor 151	419	46637	6.13	7	Cell membrane	NA	Proton-sensing G-protein coupled receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	5
+NX_Q8TDV2	Probable G-protein coupled receptor 148	347	38288	8.81	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	2
+NX_Q8TDV5	Glucose-dependent insulinotropic receptor	335	36889	9.1	7	Cell membrane	NA	Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.	NA	Belongs to the G-protein coupled receptor 1 family.	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	PE1	X
+NX_Q8TDW0	Volume-regulated anion channel subunit LRRC8C	803	92450	7.54	4	Golgi apparatus;Endoplasmic reticulum membrane;Cell membrane	NA	Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.	NA	Belongs to the LRRC8 family.	Miscellaneous transport and binding events	PE1	1
+NX_Q8TDW4	Suppressor of tumorigenicity 7 protein-like	575	64779	7.26	2	Membrane;Centrosome	NA	NA	NA	Belongs to the ST7 family.	NA	PE1	1
+NX_Q8TDW5	Synaptotagmin-like protein 5	730	81523	8.96	0	Membrane;Nucleoplasm;Cytosol;Cytoskeleton	NA	May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.	NA	NA	NA	PE1	X
+NX_Q8TDW7	Protocadherin Fat 3	4557	501978	4.72	1	Membrane	NA	May play a role in the interactions between neurites derived from specific subsets of neurons during development.	NA	NA	NA	PE1	11
+NX_Q8TDX5	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase	336	38035	6.52	0	NA	NA	Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.	NA	Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.	Secondary metabolite metabolism; quinolate metabolism.;Tryptophan metabolism;Metabolic pathways;Tryptophan catabolism	PE1	2
+NX_Q8TDX6	Chondroitin sulfate N-acetylgalactosaminyltransferase 1	532	61294	8.63	1	Golgi stack membrane;Cytoskeleton	NA	Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan (By similarity).	N-glycosylated.	Belongs to the chondroitin N-acetylgalactosaminyltransferase family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Metabolic pathways;Chondroitin sulfate biosynthesis	PE1	8
+NX_Q8TDX7	Serine/threonine-protein kinase Nek7	302	34551	8.49	0	Cytoplasm;Nucleoplasm;Spindle pole;Centrosome;Nucleus	NA	Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.	Phosphorylation at Ser-195 required for its activation.;NEK7 is phosphorylated by NEK9	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	Nuclear Pore Complex (NPC) Disassembly;Activation of NIMA Kinases NEK9, NEK6, NEK7	PE1	1
+NX_Q8TDX9	Polycystic kidney disease protein 1-like 1	2849	315435	6.64	11	Cilium membrane	Heterotaxy, visceral, 8, autosomal	Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.	NA	Belongs to the polycystin family.	NA	PE1	7
+NX_Q8TDY2	RB1-inducible coiled-coil protein 1	1594	183091	5.3	0	Cytoplasm;Nucleus membrane;Preautophagosomal structure;Lysosome;Cytosol;Nucleus	NA	Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).	RB1CC1 is phosphorylated by ULK2	Belongs to the ATG17 family.	Macroautophagy	PE1	8
+NX_Q8TDY3	Actin-related protein T2	377	41702	5.28	0	Cytoskeleton	NA	NA	NA	Belongs to the actin family.	NA	PE1	1
+NX_Q8TDY4	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3	903	99155	5.98	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle	NA	Promotes cell proliferation.	NA	NA	Endocytosis;Fc gamma R-mediated phagocytosis	PE1	1
+NX_Q8TDY8	Immunoglobulin superfamily DCC subclass member 4	1250	134210	5.81	1	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	Belongs to the immunoglobulin superfamily. DCC family.	NA	PE1	15
+NX_Q8TDZ2	[F-actin]-monooxygenase MICAL1	1067	117875	6	0	Cytoplasm;Midbody;Cytoskeleton	NA	Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking.	NA	Belongs to the Mical family.	Factors involved in megakaryocyte development and platelet production	PE1	6
+NX_Q8TE02	Elongator complex protein 5	316	34841	4.81	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:22854966). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation (PubMed:16850183).	NA	Belongs to the ELP5 family.	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.;HATs acetylate histones	PE1	17
+NX_Q8TE04	Pantothenate kinase 1	598	64339	7.51	0	Cytoplasm	NA	Plays a role in the physiological regulation of the intracellular CoA concentration.	NA	Belongs to the type II pantothenate kinase family.	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.;Pantothenate and CoA biosynthesis;Metabolic pathways;Coenzyme A biosynthesis	PE1	10
+NX_Q8TE12	LIM homeobox transcription factor 1-alpha	382	42747	7.03	0	Golgi apparatus;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).	NA	NA	NA	PE1	1
+NX_Q8TE23	Taste receptor type 1 member 2	839	95183	6.08	7	Cell membrane	NA	Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.	NA	Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.	Taste transduction;Carbohydrate digestion and absorption;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	1
+NX_Q8TE49	OTU domain-containing protein 7A	926	100677	8.68	0	Nucleolus;Cytoplasm;Cytosol;Nucleus	NA	Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains.	NA	Belongs to the peptidase C64 family.	Ovarian tumor domain proteases	PE1	15
+NX_Q8TE54	Anion exchange transporter	656	72213	8.17	11	Recycling endosome membrane	NA	Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.	NA	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Gastric acid secretion;Multifunctional anion exchangers	PE1	8
+NX_Q8TE56	A disintegrin and metalloproteinase with thrombospondin motifs 17	1095	121127	8.47	0	Nucleoplasm;Extracellular matrix	Weill-Marchesani syndrome 4	NA	The precursor is cleaved by a furin endopeptidase.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	15
+NX_Q8TE57	A disintegrin and metalloproteinase with thrombospondin motifs 16	1224	136203	8.99	0	Extracellular matrix;Mitochondrion;Nucleus membrane;Nucleoplasm;Midbody ring	NA	NA	The precursor is cleaved by a furin endopeptidase.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	Degradation of the extracellular matrix;O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	5
+NX_Q8TE58	A disintegrin and metalloproteinase with thrombospondin motifs 15	950	103287	8.94	0	Cytosol;Extracellular matrix	NA	NA	Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).;The precursor is cleaved by a furin endopeptidase.	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	11
+NX_Q8TE59	A disintegrin and metalloproteinase with thrombospondin motifs 19	1207	134048	7.8	0	Cytoplasmic vesicle;Extracellular matrix;Midbody	NA	NA	The precursor is cleaved by a furin endopeptidase.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	5
+NX_Q8TE60	A disintegrin and metalloproteinase with thrombospondin motifs 18	1221	135167	8.91	0	Spindle;Extracellular matrix;Midbody	Microcornea, myopic chorioretinal atrophy, and telecanthus	NA	Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).;The precursor is cleaved by a furin endopeptidase.	NA	Degradation of the extracellular matrix;O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	16
+NX_Q8TE67	Epidermal growth factor receptor kinase substrate 8-like protein 3	593	66861	8.09	0	Cytoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the EPS8 family.	NA	PE1	1
+NX_Q8TE68	Epidermal growth factor receptor kinase substrate 8-like protein 1	723	80251	5.76	0	Cytoplasm;Cytosol	NA	Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.	NA	Belongs to the EPS8 family.	NA	PE1	19
+NX_Q8TE69	Protein CXorf40A	158	17891	6.43	0	NA	NA	May have an important role of cell protection in inflammation reaction.	NA	NA	NA	PE1	X
+NX_Q8TE73	Dynein heavy chain 5, axonemal	4624	529021	5.79	0	Cilium axoneme	Ciliary dyskinesia, primary, 3	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.	NA	Belongs to the dynein heavy chain family.	NA	PE1	5
+NX_Q8TE76	MORC family CW-type zinc finger protein 4	937	106348	7.22	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	X
+NX_Q8TE77	Protein phosphatase Slingshot homolog 3	659	72996	5.19	0	Nucleus speckle;Cell membrane;Cytosol;Nucleus;Cytoskeleton	NA	Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity).	NA	Belongs to the protein-tyrosine phosphatase family.	Regulation of actin cytoskeleton	PE1	11
+NX_Q8TE82	SH3 domain and tetratricopeptide repeat-containing protein 1	1336	146961	5.85	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	4
+NX_Q8TE85	Grainyhead-like protein 3 homolog	626	70345	6.4	0	Nucleoplasm;Nucleus	Van der Woude syndrome 2	Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). Xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122).	NA	Belongs to the grh/CP2 family. Grainyhead subfamily.	NA	PE1	1
+NX_Q8TE96	ATP-dependent RNA helicase DQX1	717	79476	4.93	0	Cytosol;Nucleus;Cell membrane	NA	NA	NA	NA	NA	PE1	2
+NX_Q8TE99	2-phosphoxylose phosphatase 1	480	55240	9.17	1	Golgi apparatus membrane	NA	Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.	NA	Belongs to the histidine acid phosphatase family.	NA	PE1	3
+NX_Q8TEA1	Putative methyltransferase NSUN6	469	51770	8.18	0	Golgi apparatus	NA	May have S-adenosyl-L-methionine-dependent methyl-transferase activity.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	tRNA modification in the nucleus and cytosol	PE1	10
+NX_Q8TEA7	TBC domain-containing protein kinase-like protein	893	100679	6.12	0	Cytoplasm;Nucleolus;Nucleoplasm;Spindle;Midbody	Hypotonia, infantile, with psychomotor retardation and characteristic facies 3	Involved in the modulation of mTOR signaling and expression of mTOR complex components (PubMed:27040691, PubMed:23977024). Involved in the regulation of cell proliferation and growth (PubMed:23977024, PubMed:24576458). Involved in the control of actin-cytoskeleton organization (PubMed:23977024).	NA	Belongs to the protein kinase superfamily.	NA	PE1	4
+NX_Q8TEA8	D-aminoacyl-tRNA deacylase 1	209	23424	8.35	0	Nucleolus;Cytosol;Cytoplasm;Nucleus	NA	Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034).;An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.	Preferentially phosphorylated in cells arrested early in S phase (PubMed:15653697). Phosphorylation in the C-terminus weakens the interaction with CDC45 (PubMed:20065034).	Belongs to the DTD family.	NA	PE1	20
+NX_Q8TEB1	DDB1- and CUL4-associated factor 11	546	61670	5.97	0	Nucleoplasm	NA	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	NA	NA	Protein modification; protein ubiquitination.;Neddylation	PE1	14
+NX_Q8TEB7	E3 ubiquitin-protein ligase RNF128	428	46521	5.92	1	Endomembrane system;Perinuclear region;Cytoskeleton	NA	E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.	Auto-ubiquitinated. Controls the development of T-cell clonal anergy by ubiquitination.	NA	Protein modification; protein ubiquitination.;Ub-specific processing proteases;Ovarian tumor domain proteases	PE1	X
+NX_Q8TEB9	Rhomboid-related protein 4	315	35823	8.47	4	Mitochondrion membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia.	NA	Belongs to the peptidase S54 family.	NA	PE1	2
+NX_Q8TEC5	E3 ubiquitin-protein ligase SH3RF2	729	79320	9.96	0	Nucleoplasm;Nucleus	NA	Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623).	Autoubiquitinated.	Belongs to the SH3RF family.	Protein modification; protein ubiquitination.	PE1	5
+NX_Q8TED0	U3 small nucleolar RNA-associated protein 15 homolog	518	58415	9.18	0	Endoplasmic reticulum;Nucleolus	NA	Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.	NA	NA	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	5
+NX_Q8TED1	Probable glutathione peroxidase 8	209	23881	9.41	1	Membrane;Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the glutathione peroxidase family.	Detoxification of Reactive Oxygen Species	PE1	5
+NX_Q8TED4	Glucose-6-phosphate exchanger SLC37A2	501	54436	6.36	12	Endoplasmic reticulum membrane	NA	Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.	NA	Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.	Gluconeogenesis	PE1	11
+NX_Q8TED9	Actin filament-associated protein 1-like 1	768	86432	6.38	0	Cytoplasm;Stress fiber;Podosome;Invadopodium	NA	May be involved in podosome and invadosome formation.	NA	NA	NA	PE1	5
+NX_Q8TEE9	Histone deacetylase complex subunit SAP25	199	20873	7.64	0	Cytoplasm;Nucleus	NA	Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.	NA	NA	NA	PE1	7
+NX_Q8TEF2	Uncharacterized protein C10orf105	133	14519	8.75	1	Membrane	NA	NA	NA	NA	NA	PE1	10
+NX_Q8TEH3	DENN domain-containing protein 1A	1009	110577	6.51	0	Presynaptic cell membrane;Nucleoplasm;Clathrin-coated vesicle membrane;Cytoplasmic vesicle;Cytosol	NA	Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity).	Phosphorylated on serine and/or threonine in an Akt-dependent manner. Phosphorylation probably regulates the guanine nucleotide exchange factor (GEF) activity, possibly by disrupting an intramolecular interaction between the DENN domain and the C-terminus of the protein, thereby relieving the autoinhibition.	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	9
+NX_Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	882	92776	9.09	0	Nucleoplasm;Cytosol;Centrosome	NA	Has E3 ubiquitin-protein ligase activity.	Autoubiquitinated.	Belongs to the SH3RF family.	Protein modification; protein ubiquitination.	PE1	2
+NX_Q8TEK3	Histone-lysine N-methyltransferase, H3 lysine-79 specific	1537	164856	9.26	0	Nucleoplasm;Nucleus	NA	Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.	Lysine degradation;PKMTs methylate histone lysines	PE1	19
+NX_Q8TEL6	Short transient receptor potential channel 4-associated protein	797	90852	7.54	0	Cytosol	NA	Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.	NA	NA	Protein modification; protein ubiquitination.;TRP channels	PE1	20
+NX_Q8TEM1	Nuclear pore membrane glycoprotein 210	1887	205111	6.33	1	Endoplasmic reticulum membrane;Nucleus membrane;Nuclear pore complex	NA	Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.	Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.;N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).	Belongs to the NUP210 family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	3
+NX_Q8TEP8	Centrosomal protein of 192 kDa	2537	279111	5.31	0	Cytosol;Centrosome;Centriole	NA	Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:25042804, PubMed:17980596, PubMed:18207742). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:25042804, PubMed:17980596, PubMed:18207742). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804).	Hydroxylation by PHD1/EGLN2 at Pro-2313 promotes ubiquitination.;Ubiquitinated by a SCF(SKP2) complex following proline hydroxylation.	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	18
+NX_Q8TEQ0	Sorting nexin-29	813	91254	5.86	0	NA	NA	NA	NA	Belongs to the sorting nexin family.	NA	PE1	16
+NX_Q8TEQ6	Gem-associated protein 5	1508	168589	6.17	0	Cytoplasm;Gem;Nucleoplasm;Cytosol;Nucleus	NA	Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:16857593, PubMed:18984161, PubMed:20513430). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:18984161). GEMIN5 acts as the snRNA-binding protein of the SMN complex (PubMed:11714716, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.25). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887).	NA	Belongs to the WD repeat gemin-5 family.	RNA transport;snRNP Assembly	PE1	5
+NX_Q8TEQ8	GPI ethanolamine phosphate transferase 3	1089	118699	8.38	14	Nucleoplasm;Endoplasmic reticulum membrane;Nucleolus	Hyperphosphatasia with mental retardation syndrome 2	Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond.	NA	Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	9
+NX_Q8TER0	Sushi, nidogen and EGF-like domain-containing protein 1	1413	152204	6.59	0	Secreted	NA	NA	NA	NA	NA	PE1	2
+NX_Q8TER5	Rho guanine nucleotide exchange factor 40	1519	164658	5.8	0	Nucleoplasm;Cytosol;Cytoplasm	NA	May act as a guanine nucleotide exchange factor (GEF).	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	14
+NX_Q8TES7	Fas-binding factor 1	1133	125446	6.62	0	Spindle pole;Cell junction;Centrosome;Centriole	NA	Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis.	NA	NA	Anchoring of the basal body to the plasma membrane	PE1	17
+NX_Q8TET4	Neutral alpha-glucosidase C	914	104334	5.82	0	Nucleoplasm;Cytoskeleton	NA	Has alpha-glucosidase activity.	NA	Belongs to the glycosyl hydrolase 31 family.	Galactose metabolism;Starch and sucrose metabolism;Metabolic pathways	PE1	15
+NX_Q8TEU7	Rap guanine nucleotide exchange factor 6	1601	179423	5.98	0	Cytoplasm;Cytosol;Centrosome;Cell membrane	NA	Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.	NA	NA	NA	PE1	5
+NX_Q8TEU8	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2	576	63941	5.85	0	Secreted	NA	Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity).	NA	Belongs to the WFIKKN family.	NA	PE1	17
+NX_Q8TEV8	Smith-Magenis syndrome chromosomal region candidate gene 5 protein	140	15285	10.67	0	NA	NA	NA	NA	NA	NA	PE2	17
+NX_Q8TEV9	Guanine nucleotide exchange protein SMCR8	937	105022	5.36	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27193190, PubMed:27103069, PubMed:27559131, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531).	Phosphorylation by TBK1 is required to promote autophagosome maturation (PubMed:27103069). Phosphorylated by ULK1 (PubMed:27103069).	Belongs to the SMCR8 family.	NA	PE1	17
+NX_Q8TEW0	Partitioning defective 3 homolog	1356	151423	7.41	0	Cytoplasm;Cell cortex;Cell membrane;Endomembrane system;Adherens junction;Cell junction;Tight junction;Cytosol;Cytoskeleton	Neural tube defects	Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688).	Acetylated. Deacetylated by SIRT2, thereby inhibiting Schwann cell peripheral myelination.;Phosphorylation at Ser-827 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2 (By similarity). Phosphorylation by AURKA at Ser-962 is required for the normal establishment of neuronal polarity (PubMed:19812038).	Belongs to the PAR3 family.	Chemokine signaling pathway;Neuroactive ligand-receptor interaction;Endocytosis;Adherens junction;Tight junction;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Tight junction interactions	PE1	10
+NX_Q8TEW6	Docking protein 4	326	37028	8.37	0	Cytoplasmic vesicle;Cytoskeleton	NA	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.	Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.	Belongs to the DOK family. Type B subfamily.	RET signaling	PE1	16
+NX_Q8TEW8	Partitioning defective 3 homolog B	1205	132494	8.54	0	Tight junction;Cell junction;Endomembrane system	NA	Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.	PARD3B is phosphorylated by PRKCZ	Belongs to the PAR3 family.	NA	PE1	2
+NX_Q8TEX9	Importin-4	1081	118715	4.88	0	Cytoplasm;Cytosol;Nucleus	NA	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.	NA	Belongs to the importin beta family.	NA	PE1	14
+NX_Q8TEY5	Cyclic AMP-responsive element-binding protein 3-like protein 4	395	43432	5.28	1	Endoplasmic reticulum membrane;Mitochondrion;Nucleus membrane;Nucleoplasm;Golgi apparatus membrane;Nucleus	NA	Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).	N-glycosylated in the C-terminal region.;Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).	Belongs to the bZIP family. ATF subfamily.	Cholinergic synapse;Dopaminergic synapse;Melanogenesis;Vasopressin-regulated water reabsorption;Huntington's disease;Prostate cancer;CREB3 factors activate genes	PE1	1
+NX_Q8TEY7	Ubiquitin carboxyl-terminal hydrolase 33	942	106727	5.69	0	Golgi apparatus;Nucleoplasm;Centrosome;Perinuclear region	NA	Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.	Belongs to the peptidase C19 family. USP20/USP33 subfamily.	Ub-specific processing proteases;Regulation of expression of SLITs and ROBOs	PE1	1
+NX_Q8TEZ7	Membrane progestin receptor beta	354	40464	8.69	7	Golgi apparatus;Cell membrane	NA	Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).	NA	Belongs to the ADIPOR family.	NA	PE1	6
+NX_Q8TF01	Arginine/serine-rich protein PNISR	805	92577	10.02	0	Cytosol;Nucleus speckle;Cell membrane	NA	NA	NA	Belongs to the splicing factor SR family.	NA	PE1	6
+NX_Q8TF05	Serine/threonine-protein phosphatase 4 regulatory subunit 1	950	107004	4.64	0	Nucleoplasm	NA	Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.	NA	NA	NA	PE1	18
+NX_Q8TF08	Cytochrome c oxidase subunit 7B2, mitochondrial	81	9077	9.74	1	Mitochondrion inner membrane	NA	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase VIIb family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease	PE2	4
+NX_Q8TF09	Dynein light chain roadblock-type 2	96	10855	6.91	0	Cytoskeleton	NA	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.	NA	Belongs to the GAMAD family.	Intraflagellar transport	PE1	16
+NX_Q8TF17	SH3 domain and tetratricopeptide repeat-containing protein 2	1288	144777	5.95	0	Nucleoplasm;Cytosol	Charcot-Marie-Tooth disease 4C;Mononeuropathy of the median nerve mild	NA	NA	NA	NA	PE1	5
+NX_Q8TF20	Zinc finger protein 721	911	105084	9.55	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	4
+NX_Q8TF21	Ankyrin repeat domain-containing protein 24	1146	124187	4.98	0	Cytosol;Cytoskeleton	NA	NA	NA	NA	NA	PE1	19
+NX_Q8TF27	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11	550	60549	7.82	0	NA	NA	Putative GTPase-activating protein.	NA	Belongs to the centaurin gamma-like family.	NA	PE2	10
+NX_Q8TF30	WASP homolog-associated protein with actin, membranes and microtubules	809	90924	6.67	0	Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Cytoplasmic vesicle membrane;cis-Golgi network;Cytosol	NA	Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration.	NA	NA	NA	PE1	15
+NX_Q8TF32	Zinc finger protein 431	576	67217	9.03	0	Nucleus	NA	Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8TF39	Zinc finger protein 483	744	85098	8.88	0	Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	9
+NX_Q8TF40	Folliculin-interacting protein 1	1166	130555	5.33	0	Cytoplasm	NA	Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:17028174). May regulate phosphorylation of RPS6KB1 (PubMed:18663353).	Phosphorylated by AMPK.	Belongs to the FNIP family.	NA	PE1	5
+NX_Q8TF42	Ubiquitin-associated and SH3 domain-containing protein B	649	72696	6.48	0	Cytoplasm;Nucleus;Cell membrane	NA	Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.	NA	NA	NA	PE1	11
+NX_Q8TF44	C2 calcium-dependent domain-containing protein 4C	421	44576	9.75	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the C2CD4 family.	NA	PE1	19
+NX_Q8TF45	Zinc finger protein 418	676	77858	8.75	0	Nucleus	NA	Transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8TF46	DIS3-like exonuclease 1	1054	120787	6.09	0	Cytoplasm;Cytosol;Centrosome;Cell membrane	NA	Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.	NA	Belongs to the RNR ribonuclease family.	NA	PE1	15
+NX_Q8TF47	Zinc finger protein 90 homolog	636	73031	8.37	0	Cytoplasmic vesicle;Centrosome;Nucleus;Cell membrane	NA	Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.;Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_Q8TF50	Zinc finger protein 526	670	73622	6.01	0	Golgi apparatus;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8TF61	F-box only protein 41	875	94496	8.6	0	Nucleoplasm;Cytosol;Cell membrane	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	2
+NX_Q8TF62	Probable phospholipid-transporting ATPase IM	1192	135868	6.56	10	Cytoplasmic vesicle;Golgi apparatus;Nucleoplasm;Cell membrane	NA	Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases;Neutrophil degranulation	PE1	15
+NX_Q8TF63	Dendritic cell nuclear protein 1	244	26704	9.97	0	Cytoplasm;Nucleus	NA	Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter.	NA	NA	NA	PE1	5
+NX_Q8TF64	PDZ domain-containing protein GIPC3	312	33982	5.5	0	Golgi apparatus;Nucleoplasm;Nucleus	Deafness, autosomal recessive, 15	Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion.	NA	Belongs to the GIPC family.	NA	PE1	19
+NX_Q8TF65	PDZ domain-containing protein GIPC2	315	34354	6.07	0	Nucleoplasm;Cytosol;Cytoplasm	NA	NA	NA	Belongs to the GIPC family.	NA	PE1	1
+NX_Q8TF66	Leucine-rich repeat-containing protein 15	581	64366	6.24	1	Membrane;Cytoplasmic vesicle;Cell membrane	NA	NA	NA	NA	NA	PE1	3
+NX_Q8TF68	Zinc finger protein 384	577	63219	9.18	0	Nucleoplasm;Nucleus	NA	Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	12
+NX_Q8TF71	Monocarboxylate transporter 10	515	55493	7.87	12	Cytoplasmic vesicle;Cell junction;Cell membrane;Basolateral cell membrane	NA	Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).	Not N-glycosylated.	Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.	Protein digestion and absorption;Amino acid transport across the plasma membrane	PE1	6
+NX_Q8TF72	Protein Shroom3	1996	216857	7.87	0	Apical cell membrane;Adherens junction;Cytoskeleton	NA	Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity).	NA	Belongs to the shroom family.	NA	PE1	4
+NX_Q8TF74	WAS/WASL-interacting protein family member 2	440	46289	10.93	0	Nucleoplasm;Cytoskeleton	NA	Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.	NA	Belongs to the verprolin family.	Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs	PE1	17
+NX_Q8TF76	Serine/threonine-protein kinase haspin	798	88495	9.32	0	Nucleoplasm;Spindle;Nucleus;Chromosome	NA	Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.	Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.	NA	PE1	17
+NX_Q8WTP8	Apoptosis-enhancing nuclease	325	36350	9.4	0	Nucleoplasm;Nucleolus;Nucleus membrane;Nucleus	NA	Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.	NA	NA	NA	PE1	15
+NX_Q8WTP9	X antigen family member 3	111	12302	4.4	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q8WTQ1	Beta-defensin 104	72	8526	9.41	0	Secreted	NA	Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	8
+NX_Q8WTQ4	Uncharacterized protein C16orf78	265	30819	9.8	0	NA	NA	NA	NA	NA	NA	PE1	16
+NX_Q8WTQ7	Rhodopsin kinase GRK7	553	62212	6.18	0	Membrane	NA	Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).	Autophosphorylated in vitro at Ser-490. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Chemokine signaling pathway;Endocytosis;Phototransduction;Inactivation, recovery and regulation of the phototransduction cascade	PE1	3
+NX_Q8WTR2	Dual specificity protein phosphatase 19	217	24194	6.11	0	Nucleoplasm	NA	Has a dual specificity toward Ser/Thr and Tyr-containing proteins.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	2
+NX_Q8WTR4	Glycerophosphodiester phosphodiesterase domain-containing protein 5	605	68586	7.64	6	Golgi apparatus;Endomembrane system;Growth cone;Perinuclear region	NA	Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity).	Intramolecular disulfide bond between Cys-25 and Cys-571 is reduced by PRDX1.	Belongs to the glycerophosphoryl diester phosphodiesterase family.	Glycerophospholipid catabolism	PE1	11
+NX_Q8WTR7	Zinc finger protein 473	871	100182	8.63	0	Nucleoplasm;Nucleus	NA	Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway;SLBP independent Processing of Histone Pre-mRNAs;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	19
+NX_Q8WTR8	Netrin-5	489	53174	9.63	0	Endoplasmic reticulum;Secreted	NA	Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube.	NA	NA	NA	PE2	19
+NX_Q8WTS1	1-acylglycerol-3-phosphate O-acyltransferase ABHD5	349	39096	6.17	0	Cytoplasmic vesicle;Cytoplasm;Cytosol;Lipid droplet	Chanarin-Dorfman syndrome	Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid (PubMed:18606822). Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity).	NA	Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.	Triglyceride catabolism	PE1	3
+NX_Q8WTS6	Histone-lysine N-methyltransferase SETD7	366	40721	4.5	0	Nucleolus;Nucleus;Chromosome	NA	Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.	Lysine degradation;PKMTs methylate histone lysines	PE1	4
+NX_Q8WTT0	C-type lectin domain family 4 member C	213	25038	6.59	1	Cell membrane	NA	Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283).	NA	NA	Dectin-2 family;Neutrophil degranulation	PE1	12
+NX_Q8WTT2	Nucleolar complex protein 3 homolog	800	92548	9.22	0	Nucleoplasm;Nucleus speckle;Nucleolus	NA	May be required for adipogenesis.	NA	Belongs to the CBF/MAK21 family.	NA	PE1	10
+NX_Q8WTU0	Protein DDI1 homolog 1	396	44124	5.51	0	NA	NA	Probable aspartic protease (Probable). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612).	NA	Belongs to the DDI1 family.	NA	PE1	11
+NX_Q8WTU2	Scavenger receptor cysteine-rich domain-containing group B protein	575	60819	5.57	0	Secreted	NA	NA	NA	NA	NA	PE1	7
+NX_Q8WTV0	Scavenger receptor class B member 1	552	60878	8.55	2	Cytoplasmic vesicle;Caveola;Cell membrane	NA	(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694).;Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).	The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.;N-glycosylated.	Belongs to the CD36 family.	Phagosome;Fat digestion and absorption;Bile secretion;Vitamin digestion and absorption;Hepatitis C;Scavenging by Class B Receptors;HDL clearance	PE1	12
+NX_Q8WTV1	THAP domain-containing protein 3	239	27059	10.26	0	Nucleoplasm;Mitochondrion;Nucleolus	NA	Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.	NA	NA	NA	PE1	1
+NX_Q8WTW3	Conserved oligomeric Golgi complex subunit 1	980	108978	6.96	0	Golgi apparatus membrane	Congenital disorder of glycosylation 2G	Required for normal Golgi function.	NA	Belongs to the COG1 family.	Intra-Golgi traffic;COPI-mediated anterograde transport;Retrograde transport at the Trans-Golgi-Network	PE1	17
+NX_Q8WTW4	GATOR complex protein NPRL2	380	43658	6.1	0	Cytosol;Lysosome membrane	Epilepsy, familial focal, with variable foci 2	As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.;Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.	NA	Belongs to the NPR2 family.	NA	PE1	3
+NX_Q8WTX7	Cytosolic arginine sensor for mTORC1 subunit 1	329	36275	5.05	0	Cytosol	NA	Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.	NA	Belongs to the GATS family.	NA	PE1	22
+NX_Q8WTX9	Probable palmitoyltransferase ZDHHC1	485	54818	10.35	4	Membrane;Cytosol	NA	NA	NA	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	16
+NX_Q8WTZ3	Zinc finger protein ENSP00000375192	238	27158	8.81	0	Nucleus	NA	NA	NA	NA	NA	PE2	19
+NX_Q8WTZ4	Putative inactive carbonic anhydrase 5B-like protein	195	22622	10.76	0	NA	NA	NA	NA	Belongs to the alpha-carbonic anhydrase family.	NA	PE5	X
+NX_Q8WU03	Glycine N-acyltransferase-like protein 2	294	34277	6.22	0	Endoplasmic reticulum;Mitochondrion	NA	Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.	Acetylation at Lys-19 drastically decreases the production of N-oleoyl and N-arachidonoyl glycines.	Belongs to the glycine N-acyltransferase family.	Conjugation of salicylate with glycine;Conjugation of benzoate with glycine	PE1	11
+NX_Q8WU08	Serine/threonine-protein kinase 32A	396	46369	6.87	0	Centrosome;Cell membrane	NA	NA	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	5
+NX_Q8WU10	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1	500	55793	5.58	0	Cytoplasm;Nucleus speckle;Nucleus;Sarcomere	Myopathy, myofibrillar, 8	Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (PubMed:27745833). Required for normal sarcomere structure and muscle fiber integrity (By similarity).	NA	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.	NA	PE1	12
+NX_Q8WU17	E3 ubiquitin-protein ligase RNF139	664	75994	5.99	12	Endoplasmic reticulum membrane	Renal cell carcinoma	E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.	Autoubiquitinated. Ubiquitination is induced by sterol and leads to ist degradation via the ubiquitin-proteasome pathway.	NA	Protein modification; protein ubiquitination.;ER Quality Control Compartment (ERQC)	PE1	8
+NX_Q8WU20	Fibroblast growth factor receptor substrate 2	508	57029	5.65	0	Endomembrane system;Cell junction	NA	Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.	Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).;Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases.;FRS2 is phosphorylated by INSR;FRS2 is phosphorylated by FGFR1;FRS2 is phosphorylated by FGFR3;FRS2 is phosphorylated by NTRK1;FRS2 is phosphorylated by ULK2;FRS2 is phosphorylated by FGFR1 (Phosphotyrosine:PTM-0255);FRS2 is phosphorylated by FGFR4;FRS2 is phosphorylated by ALK (Phosphotyrosine:PTM-0255);FRS2 is phosphorylated by FGFR2 (Phosphotyrosine:PTM-0255)	NA	Neurotrophin signaling pathway;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;FRS-mediated FGFR2 signaling;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;Frs2-mediated activation;Signaling by FGFR4 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR3 fusions in cancer;RET signaling;Activated NTRK2 signals through FRS2 and FRS3	PE1	12
+NX_Q8WU39	Marginal zone B- and B1-cell-specific protein	189	20694	5.37	0	Cytoplasm;Endoplasmic reticulum lumen;Secreted	NA	Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.;Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity).;May be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.	Forms an interchain disulfide bond with IgM monomers.	Belongs to the MZB1 family.	NA	PE1	5
+NX_Q8WU43	Uncharacterized protein C2orf15	125	13691	5.92	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q8WU49	Uncharacterized protein C7orf33	177	19475	10.26	0	NA	NA	NA	NA	NA	NA	PE2	7
+NX_Q8WU58	Protein FAM222B	562	59652	9.35	0	Nucleoplasm	NA	NA	NA	Belongs to the FAM222 family.	NA	PE1	17
+NX_Q8WU66	Thrombospondin-type laminin G domain and EAR repeat-containing protein	669	74924	6.01	0	Cell surface;Stereocilium;Secreted	Ectodermal dysplasia 14, hair/tooth type with or without hypohidrosis;Deafness, autosomal recessive, 98	Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway (PubMed:27736875). May play a role in development or function of the auditory system (PubMed:22678063).	NA	NA	NA	PE1	21
+NX_Q8WU67	Phospholipase ABHD3	409	46009	6.7	1	Membrane;Nucleoplasm;Cell membrane;Cytoplasmic vesicle	NA	Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.	NA	Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.	Synthesis of PC	PE1	18
+NX_Q8WU68	Splicing factor U2AF 26 kDa subunit	220	25744	6.7	0	Cytoplasm;Nucleoplasm;Nucleus speckle;Nucleus	NA	RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).	NA	Belongs to the splicing factor SR family.	Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	19
+NX_Q8WU76	Sec1 family domain-containing protein 2	684	75127	6.21	0	Nucleoplasm	NA	May be involved in protein transport.	NA	Belongs to the STXBP/unc-18/SEC1 family.	NA	PE1	4
+NX_Q8WU79	Stromal membrane-associated protein 2	429	46786	9.01	0	Cytoplasm	NA	GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).	NA	NA	Endocytosis	PE1	1
+NX_Q8WU90	Zinc finger CCCH domain-containing protein 15	426	48602	5.22	0	Cytoplasm;Cytosol;Nucleus	NA	Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155).	NA	Belongs to the ZC3H15/TMA46 family.	NA	PE1	2
+NX_Q8WUA2	Peptidyl-prolyl cis-trans isomerase-like 4	492	57225	5.63	0	Nucleoplasm;Nucleus	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).	NA	Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.	mRNA Splicing - Major Pathway	PE1	6
+NX_Q8WUA4	General transcription factor 3C polypeptide 2	911	100680	6.94	0	Nucleoplasm;Nucleus	NA	Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.	NA	NA	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter	PE1	2
+NX_Q8WUA7	TBC1 domain family member 22A	517	59121	5.63	0	Golgi apparatus;Nucleoplasm;Cytoplasmic vesicle	NA	May act as a GTPase-activating protein for Rab family protein(s).	NA	NA	NA	PE1	22
+NX_Q8WUA8	Tsukushin	353	37807	6.38	0	Nucleoplasm;Secreted;Nucleus	NA	NA	NA	NA	NA	PE1	11
+NX_Q8WUB2	Protein FAM216A	273	30792	9.39	0	Cytoskeleton	NA	NA	NA	Belongs to the FAM216 family.	NA	PE1	12
+NX_Q8WUB8	PHD finger protein 10	498	56051	6.23	0	Nucleoplasm;Nucleus	NA	Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).	NA	Belongs to the SAYP family.	NA	PE1	6
+NX_Q8WUD1	Ras-related protein Rab-2B	216	24214	7.69	0	Endoplasmic reticulum membrane;Cell membrane;Golgi apparatus membrane	NA	Required for protein transport from the endoplasmic reticulum to the Golgi complex.	NA	Belongs to the small GTPase superfamily. Rab family.	RAB geranylgeranylation	PE1	14
+NX_Q8WUD4	Coiled-coil domain-containing protein 12	166	19181	6.81	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	Spliceosome	PE1	3
+NX_Q8WUD6	Cholinephosphotransferase 1	406	45097	6.45	8	Cytoplasmic vesicle;Golgi apparatus membrane	NA	Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.	NA	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.;Glycerophospholipid metabolism;Ether lipid metabolism;Metabolic pathways;Synthesis of PC	PE1	12
+NX_Q8WUE5	Cancer/testis antigen 55	264	29052	5.26	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	X
+NX_Q8WUF5	RelA-associated inhibitor	828	89091	6.37	0	Cytoplasm;Cytosol;Nucleus	NA	Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540).	NA	Belongs to the iASPP family.	Regulation of TP53 Activity through Association with Co-factors	PE1	19
+NX_Q8WUF8	Cotranscriptional regulator FAM172A	416	47972	5.75	0	Cytoplasm;Nucleoplasm;Endoplasmic reticulum;Cytosol;Nucleus	NA	Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity.	NA	Belongs to the FAM172 family.	NA	PE1	5
+NX_Q8WUG5	Solute carrier family 22 member 17	538	57686	7.14	11	Vacuole membrane;Cell membrane	NA	Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Iron uptake and transport	PE1	14
+NX_Q8WUH1	Protein Churchill	139	16111	5.35	0	Cytoplasm;Cytosol;Nucleus	NA	Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself.	NA	Belongs to the Churchill family.	NA	PE1	14
+NX_Q8WUH2	Transforming growth factor-beta receptor-associated protein 1	860	97158	6.1	0	Cytoplasm;Early endosome;Cytoplasmic vesicle	NA	Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.;Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (PubMed:25266290).	NA	Belongs to the TRAP1 family.	NA	PE1	2
+NX_Q8WUH6	Transmembrane protein 263	116	11748	9.3	2	Membrane	NA	NA	NA	Belongs to the TMEM263 family.	NA	PE1	12
+NX_Q8WUI4	Histone deacetylase 7	952	102927	7.24	0	Cytoplasm;Cytosol;Nucleus	NA	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758).	May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181.	Belongs to the histone deacetylase family. HD type 2 subfamily.	SUMOylation of DNA damage response and repair proteins;Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of PTEN gene transcription	PE1	12
+NX_Q8WUJ0	Serine/threonine/tyrosine-interacting protein	223	25492	5.89	0	Nucleoplasm;Cytosol;Nucleus	NA	Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894). Plays a role in spermatogenesis (By similarity).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.	NA	PE1	14
+NX_Q8WUJ1	Neuferricin	264	28690	8.73	0	Nucleolus;Centrosome;Secreted;Nucleus membrane	NA	Heme-binding protein which promotes neuronal but not astrocyte differentiation.	NA	Belongs to the cytochrome b5 family. MAPR subfamily.	NA	PE1	17
+NX_Q8WUJ3	Cell migration-inducing and hyaluronan-binding protein	1361	152998	7.98	0	Cytoplasm;Cell membrane;Secreted;Clathrin-coated pit;Endoplasmic reticulum;Nucleus	NA	Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.	N-glycosylated; glycosylation is not necessary for HA-binding.	Belongs to the CEMIP family.	Hyaluronan biosynthesis and export	PE1	15
+NX_Q8WUK0	Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1	201	22844	9.8	0	Mitochondrion inner membrane;Mitochondrion	NA	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (PubMed:24709986).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.;Synthesis of PG	PE1	11
+NX_Q8WUM0	Nuclear pore complex protein Nup133	1156	128979	4.97	0	Kinetochore;Nucleus membrane;Nuclear pore complex	Nephrotic syndrome 18;Galloway-Mowat syndrome 8	Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222).	NA	Belongs to the nucleoporin Nup133 family.	RNA transport;Separation of Sister Chromatids;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	1
+NX_Q8WUM4	Programmed cell death 6-interacting protein	868	96023	6.13	0	Extracellular exosome;Tight junction;Melanosome;Centrosome;Cytoplasmic vesicle;Cytosol;Midbody ring	NA	(Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).;Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).	May be phosphorylated on tyrosine residues by activated PDGFRB.;PDCD6IP is phosphorylated by SRC (Phosphotyrosine:PTM-0255)	NA	Endocytosis;Uptake and function of anthrax toxins;Budding and maturation of HIV virion	PE1	3
+NX_Q8WUM9	Sodium-dependent phosphate transporter 1	679	73700	6.65	10	Membrane;Cytoplasmic vesicle	NA	(Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).;Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification.	NA	Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.	Sodium-coupled phosphate cotransporters	PE1	2
+NX_Q8WUN7	Ubiquitin domain-containing protein 2	234	26190	5.45	0	Cytoplasm	NA	NA	NA	NA	NA	PE1	5
+NX_Q8WUP2	Filamin-binding LIM protein 1	373	40670	5.71	0	Stress fiber;Cell junction;Focal adhesion;Nucleolus	NA	Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.	NA	NA	Cell-extracellular matrix interactions	PE1	1
+NX_Q8WUQ7	Cactin	758	88702	9.17	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.	NA	Belongs to the CACTIN family.	NA	PE1	19
+NX_Q8WUR7	UPF0235 protein C15orf40	153	16353	9.85	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the UPF0235 family.	NA	PE1	15
+NX_Q8WUS8	Short-chain dehydrogenase/reductase family 42E member 1	393	44284	8.43	2	Membrane	NA	NA	NA	Belongs to the 3-beta-HSD family.	NA	PE2	16
+NX_Q8WUT4	Leucine-rich repeat neuronal protein 4	740	78843	6.82	1	Membrane	NA	May play an important role in hippocampus-dependent long-lasting memory.	NA	NA	NA	PE1	20
+NX_Q8WUT9	Solute carrier family 25 member 43	341	37718	9.91	6	Nucleoplasm;Mitochondrion inner membrane	NA	NA	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	X
+NX_Q8WUU4	Zinc finger protein 296	475	50810	9.13	0	Nucleoplasm;Centrosome;Nucleus	NA	May be a transcriptional corepressor with KLF4.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q8WUU5	GATA zinc finger domain-containing protein 1	269	28690	9.47	0	Nucleoplasm;Nucleus	Cardiomyopathy, dilated 2B	Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me).	NA	NA	NA	PE1	7
+NX_Q8WUU8	Transmembrane protein 174	243	26287	4.2	2	Endoplasmic reticulum membrane	NA	NA	NA	NA	NA	PE1	5
+NX_Q8WUW1	Protein BRICK1	75	8745	5.35	0	Cell junction;Nucleus speckle;Cytoskeleton	NA	Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).	NA	Belongs to the BRK1 family.	Regulation of actin cytoskeleton;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;VEGFA-VEGFR2 Pathway	PE1	3
+NX_Q8WUX1	Sodium-coupled neutral amino acid transporter 5	472	51457	8.53	11	Cytoplasmic vesicle;Cytosol;Cell membrane	NA	Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium.	NA	Belongs to the amino acid/polyamine transporter 2 family.	GABAergic synapse;Amino acid transport across the plasma membrane	PE1	X
+NX_Q8WUX2	Glutathione-specific gamma-glutamylcyclotransferase 2	184	20875	5.31	0	Cytosol	NA	Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.	NA	Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.	Glutathione synthesis and recycling	PE1	2
+NX_Q8WUX9	Charged multivesicular body protein 7	453	50911	5.26	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus envelope	NA	ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878).	NA	Belongs to the SNF7 family.	Endocytosis;Macroautophagy;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	8
+NX_Q8WUY1	Protein THEM6	208	23865	9.71	0	Cytosol;Nucleus speckle;Secreted	NA	NA	NA	Belongs to the THEM6 family.	NA	PE1	8
+NX_Q8WUY3	Protein prune homolog 2	3088	340635	4.34	0	Cytoplasm	NA	May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.	NA	Belongs to the PPase class C family. Prune subfamily.	NA	PE1	9
+NX_Q8WUY8	N-acetyltransferase 14	206	21650	10.75	1	Membrane;Mitochondrion	NA	Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro.	NA	Belongs to the camello family.	NA	PE1	19
+NX_Q8WUY9	DEP domain-containing protein 1B	529	61771	9.04	0	Nucleoplasm;Golgi apparatus;Cytosol	NA	NA	NA	NA	Rho GTPase cycle	PE1	5
+NX_Q8WUZ0	B-cell CLL/lymphoma 7 protein family member C	217	23468	5.15	0	Nucleoplasm	NA	May play an anti-apoptotic role.	NA	Belongs to the BCL7 family.	NA	PE1	16
+NX_Q8WV07	Protein LTO1 homolog	137	15354	5.5	0	Nucleoplasm;Nucleus	NA	The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452). May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674).	NA	Belongs to the LTO1 family.	NA	PE1	11
+NX_Q8WV15	Transmembrane protein 255B	326	34609	6.28	4	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the TMEM255 family.	NA	PE2	13
+NX_Q8WV16	DDB1- and CUL4-associated factor 4	495	55694	9.38	0	Nucleoplasm	NA	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	NA	NA	Protein modification; protein ubiquitination.;Neddylation	PE1	14
+NX_Q8WV19	Vesicle transport protein SFT2A	159	17804	8.98	4	Membrane;Nucleoplasm;Cytosol;Nucleus	NA	May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.	NA	Belongs to the SFT2 family.	NA	PE1	6
+NX_Q8WV22	Non-structural maintenance of chromosomes element 1 homolog	266	30855	7.13	0	Cytoplasmic vesicle;Nucleoplasm;Telomere;Nucleus	NA	RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair (PubMed:29225034, PubMed:20864041). NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair (PubMed:18086888). MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors (PubMed:29225034).	Ubiquitinated.	Belongs to the NSE1 family.	SUMOylation of DNA damage response and repair proteins	PE1	16
+NX_Q8WV24	Pleckstrin homology-like domain family A member 1	401	45016	9.94	0	Nucleoplasm;Cytoplasm;Nucleolus;Cytoplasmic vesicle	NA	Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.	NA	NA	Interaction between PHLDA1 and AURKA	PE1	12
+NX_Q8WV28	B-cell linker protein	456	50466	8.18	0	Cytoplasm;Cytosol;Cell membrane	Agammaglobulinemia 4, autosomal recessive	Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.	Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways.	NA	Osteoclast differentiation;B cell receptor signaling pathway;Primary immunodeficiency;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Regulation of signaling by CBL	PE1	10
+NX_Q8WV35	Leucine-rich repeat-containing protein 29	223	23797	8.08	0	Nucleoplasm	NA	Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.	NA	NA	NA	PE1	16
+NX_Q8WV37	Zinc finger protein 480	535	61708	9.26	0	Nucleoplasm;Nucleus	NA	Involved in transcriptional regulation as an activator.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8WV41	Sorting nexin-33	574	65265	6.3	0	Membrane;Cytoplasmic vesicle membrane;Cytosol	NA	Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.	Phosphorylated.	Belongs to the sorting nexin family.	NA	PE1	15
+NX_Q8WV44	E3 ubiquitin-protein ligase TRIM41	630	71670	4.99	0	Cytoplasm;Nucleus;Nucleolus	NA	Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.	Auto-ubiquitinated.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	5
+NX_Q8WV48	Coiled-coil domain-containing protein 107	283	30509	5.04	1	Membrane;Nucleoplasm;Cell junction;Cell membrane	NA	NA	NA	NA	NA	PE1	9
+NX_Q8WV60	Pentatricopeptide repeat-containing protein 2, mitochondrial	388	43968	9.33	0	Mitochondrion	NA	Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function.	NA	Belongs to the PTCD2 family.	NA	PE1	5
+NX_Q8WV74	Nucleoside diphosphate-linked moiety X motif 8	236	25370	8.74	0	Cytosol;Nucleolus	NA	Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.	NA	Belongs to the Nudix hydrolase family.	NA	PE1	11
+NX_Q8WV83	Solute carrier family 35 member F5	523	58887	9.39	10	Membrane;Cell membrane	NA	Putative solute transporter.	NA	Belongs to the SLC35F solute transporter family.	NA	PE1	2
+NX_Q8WV92	MIT domain-containing protein 1	249	29314	8.12	0	Membrane;Midbody;Late endosome membrane;Cytoplasmic vesicle	NA	Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.	NA	NA	NA	PE1	2
+NX_Q8WV93	AFG1-like ATPase	481	54845	6.87	0	Mitochondrion membrane;Cytosol;Cell membrane	NA	Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain (PubMed:26759378, PubMed:27323408). Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress (PubMed:27323408).	NA	Belongs to the AFG1 ATPase family.	NA	PE1	6
+NX_Q8WV99	AN1-type zinc finger protein 2B	257	28023	6.5	0	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane;Nucleolus	NA	Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).	Phosphorylated by MAPK14. Phosphorylation has no effect on association with the proteasome complex.	NA	NA	PE1	2
+NX_Q8WVB3	Hexosaminidase D	486	53790	5.61	0	Cytoplasm;Mitochondrion;Nucleolus;Extracellular vesicle;Nucleus	NA	Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221).	NA	Belongs to the glycosyl hydrolase 20 family.	Other glycan degradation	PE1	17
+NX_Q8WVB6	Chromosome transmission fidelity protein 18 homolog	975	107383	6.78	0	Nucleoplasm;Nucleus	NA	Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.	NA	Belongs to the activator 1 small subunits family. CTF18 subfamily.	NA	PE1	16
+NX_Q8WVC0	RNA polymerase-associated protein LEO1	666	75404	4.38	0	Nucleoplasm;Nucleus;Centrosome;Nucleolus	NA	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.	NA	Belongs to the LEO1 family.	Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;Formation of the beta-catenin:TCF transactivating complex;E3 ubiquitin ligases ubiquitinate target proteins	PE1	15
+NX_Q8WVC6	Dephospho-CoA kinase domain-containing protein	231	26550	9.61	0	Nucleoplasm	NA	NA	NA	Belongs to the CoaE family.	NA	PE1	17
+NX_Q8WVD3	E3 ubiquitin-protein ligase RNF138	245	28193	6.5	0	Mitochondrion;Chromosome	NA	E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).	Auto-ubiquitinated.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	18
+NX_Q8WVD5	RING finger protein 141	230	25535	5.07	0	Membrane;Nucleoplasm;Cytoskeleton	NA	May be involved in spermatogenesis.	NA	NA	NA	PE1	11
+NX_Q8WVE0	EEF1A lysine methyltransferase 1	214	24506	4.47	0	Cytoplasm;Cytosol;Cell membrane	NA	Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.	Protein methylation	PE1	13
+NX_Q8WVE6	Transmembrane protein 171	324	34760	4.73	4	Membrane	NA	NA	NA	NA	NA	PE1	5
+NX_Q8WVE7	Transmembrane protein 170A	144	15250	9.3	3	Endoplasmic reticulum membrane;Nucleus envelope	NA	Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).	NA	Belongs to the TMEM170 family.	NA	PE1	16
+NX_Q8WVF1	Protein OSCP1	389	44586	5.64	0	Nucleoplasm;Basal cell membrane;Nucleolus;Cell membrane	NA	May be involved in drug clearance in the placenta.	NA	NA	NA	PE1	1
+NX_Q8WVF2	Unique cartilage matrix-associated protein	138	16563	5.47	0	Extracellular matrix	NA	May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.	Sulfated on tyrosine residues.;Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation.	Belongs to the UCMA family.	RUNX2 regulates osteoblast differentiation	PE1	10
+NX_Q8WVF5	BTB/POZ domain-containing protein KCTD4	259	29967	6.62	0	Centriolar satellite	NA	NA	NA	NA	NA	PE1	13
+NX_Q8WVH0	Complexin-3	158	17557	4.89	0	Synapse;Cell membrane	NA	Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity).	Farnesylation mediates presynaptic targeting.	Belongs to the complexin/synaphin family.	Synaptic vesicle cycle	PE1	15
+NX_Q8WVI0	Small integral membrane protein 4	70	8696	10.87	1	Membrane;Nucleoplasm;Mitochondrion;Cell membrane	NA	NA	NA	Belongs to the SMIM4 family.	NA	PE1	3
+NX_Q8WVI7	Protein phosphatase 1 regulatory subunit 1C	109	12346	6.31	0	Golgi apparatus;Nucleoplasm;Cytoplasm;Nucleolus	NA	May increase cell susceptibility to TNF-induced apoptosis.	NA	Belongs to the protein phosphatase inhibitor 1 family.	NA	PE1	2
+NX_Q8WVJ2	NudC domain-containing protein 2	157	17676	4.99	0	Kinetochore;Cytoplasm;Spindle pole;Centrosome;Cytosol;Spindle;Nucleus;Cytoskeleton	NA	May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.	NA	NA	NA	PE1	5
+NX_Q8WVJ9	Twist-related protein 2	160	18124	9.51	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	Ablepharon-macrostomia syndrome;Barber-Say syndrome;Focal facial dermal dysplasia 3, Setleis type	Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.	NA	NA	Transcriptional regulation by RUNX2	PE1	2
+NX_Q8WVK2	U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein	155	18860	11.62	0	Nucleoplasm;Nucleus	NA	May play a role in mRNA splicing.	Phosphorylated in vitro by snRNP-associated protein kinase.	Belongs to the SNUT3 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	2
+NX_Q8WVK7	Spindle and kinetochore-associated protein 2	121	14188	6.75	0	Spindle;Kinetochore	NA	Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).	NA	Belongs to the SKA2 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	17
+NX_Q8WVL7	Ankyrin repeat domain-containing protein 49	239	27290	5	0	Golgi apparatus;Nucleoplasm;Nucleolus;Nucleus	NA	Induces HBG1 expression (PubMed:16131492, PubMed:11162141). May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway (By similarity).	NA	NA	NA	PE1	11
+NX_Q8WVM0	Dimethyladenosine transferase 1, mitochondrial	346	39543	9.35	0	Mitochondrion	NA	S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.	Transcriptional activation of mitochondrial biogenesis;rRNA modification in the mitochondrion	PE1	6
+NX_Q8WVM7	Cohesin subunit SA-1	1258	144427	5.4	0	Nucleoplasm;Centromere;Nucleus;Chromosome	Mental retardation, autosomal dominant 47	Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.	Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).	Belongs to the SCC3 family.	Cell cycle;Separation of Sister Chromatids;SUMOylation of DNA damage response and repair proteins;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion;Meiotic synapsis;Estrogen-dependent gene expression	PE1	3
+NX_Q8WVM8	Sec1 family domain-containing protein 1	642	72380	5.89	0	Cytoplasm;Endoplasmic reticulum membrane;Golgi stack membrane;Nucleoplasm;Cytosol	NA	Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).	NA	Belongs to the STXBP/unc-18/SEC1 family.	COPII-mediated vesicle transport	PE1	14
+NX_Q8WVN6	Secreted and transmembrane protein 1	248	27039	7	1	Secreted;Cell membrane	NA	May be involved in thymocyte signaling.	NA	Belongs to the SECTM family.	NA	PE1	17
+NX_Q8WVN8	Ubiquitin-conjugating enzyme E2 Q2	375	42818	4.87	0	Cytoplasm	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.	Auto-ubiquitinated in vitro.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	15
+NX_Q8WVP5	Tumor necrosis factor alpha-induced protein 8-like protein 1	186	20827	9.57	0	Cytoplasm	NA	Acts as a negative regulator of mTOR activity.	NA	Belongs to the TNFAIP8 family.	PI Metabolism	PE1	19
+NX_Q8WVP7	Limb region 1 protein homolog	490	55098	5.68	9	Membrane;Cytosol	Preaxial polydactyly 2;Hypoplasia or aplasia of tibia with polydactyly;Syndactyly 4;Laurin-Sandrow syndrome;Acheiropody	Putative membrane receptor.	NA	Belongs to the LIMR family.	NA	PE1	7
+NX_Q8WVQ1	Soluble calcium-activated nucleotidase 1	401	44840	5.72	1	Golgi stack membrane;Endoplasmic reticulum membrane;Cell membrane	Epiphyseal dysplasia, multiple, 7;Desbuquois dysplasia 1	Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336).	N-glycosylated.	Belongs to the apyrase family.	Purine metabolism;Pyrimidine metabolism;Neutrophil degranulation	PE1	17
+NX_Q8WVR3	Microtubule-associated protein 11	580	62597	9.13	0	Cytoplasm;Cell membrane;Vesicle;Centriolar satellite;Cytoplasmic vesicle;Spindle;Midbody	Microcephaly 25, primary, autosomal recessive	Microtubule associated protein wich seems to play a role in spindle dynamics and cell division (PubMed:30715179, PubMed:30447097). Modulates YAP1 activity as transcriptional regulator (PubMed:30447097).	NA	NA	NA	PE1	7
+NX_Q8WVS4	WD repeat-containing protein 60	1066	122571	6.88	0	Centriolar satellite;Cilium	Short-rib thoracic dysplasia 8 with or without polydactyly	May play a role in ciliogenesis.	NA	NA	Intraflagellar transport	PE1	7
+NX_Q8WVT3	Trafficking protein particle complex subunit 12	735	79375	4.81	0	Golgi apparatus;Nucleoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Nucleus	Encephalopathy, progressive, early-onset, with brain atrophy and spasticity	Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224).	Phosphorylated as the cells enter mitosis but is dephosphorylated at or before the onset of anaphase. The phosphorylated form recruits CENPE to kinetochores more efficiently than the non-phosphorylated form.	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	2
+NX_Q8WVV4	Protein POF1B	589	68065	5.89	0	Golgi apparatus;Nucleoplasm;Tight junction	Premature ovarian failure 2B	Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development.	NA	NA	NA	PE1	X
+NX_Q8WVV5	Butyrophilin subfamily 2 member A2	523	59070	5.73	1	Membrane;Mitochondrion	NA	Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.	N-glycosylated.	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Butyrophilin (BTN) family interactions	PE1	6
+NX_Q8WVV9	Heterogeneous nuclear ribonucleoprotein L-like	542	60083	7.83	0	Nucleoplasm;Cytosol;Mitochondrion	NA	RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.	NA	NA	NA	PE1	2
+NX_Q8WVX3	Uncharacterized protein C4orf3	66	7604	5.07	1	Membrane;Endoplasmic reticulum	NA	NA	NA	NA	NA	PE1	4
+NX_Q8WVX9	Fatty acyl-CoA reductase 1	515	59357	9.25	1	Peroxisome membrane;Peroxisome	Peroxisomal fatty acyl-CoA reductase 1 disorder	Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity).	NA	Belongs to the fatty acyl-CoA reductase family.	Peroxisome;Wax biosynthesis	PE1	11
+NX_Q8WVY7	Ubiquitin-like domain-containing CTD phosphatase 1	318	36805	6.07	0	Nucleoplasm;Nucleolus;Nucleus	NA	Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.	NA	NA	NA	PE1	5
+NX_Q8WVZ1	Probable palmitoyltransferase ZDHHC19	309	34352	8.54	4	Membrane	NA	NA	NA	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	3
+NX_Q8WVZ7	E3 ubiquitin-protein ligase RNF133	376	42294	7.22	1	Endoplasmic reticulum membrane	NA	Has E3 ubiquitin-protein ligase activity.	Auto-ubiquitinated.	NA	Protein modification; protein ubiquitination.	PE1	7
+NX_Q8WVZ9	Kelch repeat and BTB domain-containing protein 7	684	77163	5.35	0	NA	NA	NA	NA	NA	Regulation of RAS by GAPs;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	13
+NX_Q8WW01	tRNA-splicing endonuclease subunit Sen15	171	18641	4.46	0	Nucleoplasm;Nucleus;Nucleolus	Pontocerebellar hypoplasia 2F	Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077). There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492).	NA	Belongs to the SEN15 family.	tRNA processing in the nucleus	PE1	1
+NX_Q8WW12	PEST proteolytic signal-containing nuclear protein	178	18925	6.86	0	Nucleoplasm;Nucleus	NA	May be involved in cell cycle regulation.	Ubiquitinated; mediated by UHRF2 and leading to its subsequent proteasomal degradation.;N-terminally acetylated in a HYPK-dependent manner by the NatA acetyltransferase complex which is composed of NAA10 and NAA15.	NA	NA	PE1	3
+NX_Q8WW14	Uncharacterized protein C10orf82	234	26343	8.67	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	10
+NX_Q8WW18	Uncharacterized protein C17orf50	174	19346	5.26	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	17
+NX_Q8WW22	DnaJ homolog subfamily A member 4	397	44798	7.52	0	Membrane;Cytosol;Cell membrane	NA	NA	NA	NA	HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	15
+NX_Q8WW24	Tektin-4	435	50649	6.01	0	Cytoskeleton;Flagellum	NA	May be a structural component of the sperm flagellum. Contributes to normal sperm motility.	NA	Belongs to the tektin family.	NA	PE1	2
+NX_Q8WW27	Putative C->U-editing enzyme APOBEC-4	367	41581	8.08	0	NA	NA	Putative C to U editing enzyme whose physiological substrate is not yet known.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	mRNA Editing: C to U Conversion;Formation of the Editosome	PE1	1
+NX_Q8WW32	High mobility group protein B4	186	22490	10.21	0	Nucleus;Chromosome	NA	NA	NA	Belongs to the HMGB family.	NA	PE1	1
+NX_Q8WW33	Gametocyte-specific factor 1	167	19266	6.04	0	Cytoplasm;Nucleoplasm	NA	Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.	NA	Belongs to the UPF0224 (FAM112) family.	NA	PE1	12
+NX_Q8WW34	Transmembrane protein 239	195	21842	8.5	2	Membrane	NA	NA	NA	NA	NA	PE1	20
+NX_Q8WW35	Tctex1 domain-containing protein 2	142	16122	4.82	0	Cytosol	Short-rib thoracic dysplasia 17 with or without polydactyly	Required for proper retrograde ciliary transport.	NA	Belongs to the dynein light chain Tctex-type family.	Intraflagellar transport	PE1	3
+NX_Q8WW36	Zinc finger CCHC domain-containing protein 13	166	18005	9.33	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_Q8WW38	Zinc finger protein ZFPM2	1151	128159	6.03	0	Nucleoplasm;Nucleus	Conotruncal heart malformations;Diaphragmatic hernia 3;Tetralogy of Fallot;46,XY sex reversal 9	Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity).	Sumoylation reduces transcriptional repression activity.	Belongs to the FOG (Friend of GATA) family.	Factors involved in megakaryocyte development and platelet production	PE1	8
+NX_Q8WW43	Gamma-secretase subunit APH-1B	257	28460	9.21	7	Membrane;Endoplasmic reticulum	NA	Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.	NA	Belongs to the APH-1 family.	EPH-ephrin mediated repulsion of cells;Amyloid fiber formation;Nuclear signaling by ERBB4;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Regulated proteolysis of p75NTR;NOTCH2 Activation and Transmission of Signal to the Nucleus;NRIF signals cell death from the nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3;NOTCH4 Activation and Transmission of Signal to the Nucleus	PE1	15
+NX_Q8WW52	Protein FAM151A	585	64028	6.19	1	Membrane	NA	NA	NA	Belongs to the FAM151 family.	NA	PE1	1
+NX_Q8WW59	SPRY domain-containing protein 4	207	23129	6.44	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	12
+NX_Q8WW62	Transmembrane emp24 domain-containing protein 6	240	27631	8.38	1	Endoplasmic reticulum membrane	NA	NA	NA	Belongs to the EMP24/GP25L family.	NA	PE1	16
+NX_Q8WWA0	Intelectin-1	313	34962	5.66	0	Secreted;Cell membrane	NA	Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499).	N-glycosylated.	NA	Antimicrobial peptides	PE1	1
+NX_Q8WWA1	Transmembrane protein 40	233	25495	5.36	2	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	3
+NX_Q8WWB3	DPY30 domain-containing protein 1	177	20893	4.64	0	NA	NA	Plays a crucial role during acrosome biogenesis.	NA	Belongs to the dpy-30 family.	NA	PE1	10
+NX_Q8WWB5	PIH1 domain-containing protein 2	315	35957	5.96	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the PIH1 family.	NA	PE1	11
+NX_Q8WWB7	Glycosylated lysosomal membrane protein	406	43864	6.1	1	Lysosome membrane	NA	NA	Highly N-glycosylated.	Belongs to the GLMP family.	NA	PE1	1
+NX_Q8WWC4	m-AAA protease-interacting protein 1, mitochondrial	291	32545	9.31	0	Mitochondrion matrix;Mitochondrion	NA	Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation (PubMed:27642048). Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) (PubMed:27642048).	NA	NA	Processing of SMDT1	PE1	2
+NX_Q8WWF1	Uncharacterized protein C1orf54	131	14923	4	0	Secreted;Cell membrane	NA	NA	NA	NA	NA	PE2	1
+NX_Q8WWF3	Serine-rich single-pass membrane protein 1	244	28167	7.64	1	Membrane	NA	NA	NA	NA	NA	PE1	7
+NX_Q8WWF5	E3 ubiquitin-protein ligase ZNRF4	429	46958	8.34	1	Endoplasmic reticulum membrane	NA	E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830). Could have a role in spermatogenesis (By similarity).	NA	NA	Protein modification; protein ubiquitination.	PE1	19
+NX_Q8WWF6	DnaJ homolog subfamily B member 3	145	16559	4.85	0	NA	NA	May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins.	NA	NA	NA	PE1	2
+NX_Q8WWF8	Calcyphosin-like protein	208	24229	5.76	0	Nucleoplasm;Cytoplasm;Cytoskeleton	NA	NA	NA	NA	NA	PE1	5
+NX_Q8WWG1	Pro-neuregulin-4, membrane-bound isoform	115	12722	6.12	1	Secreted;Cell membrane	NA	Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).	Extensive glycosylation precedes the proteolytic cleavage.;Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.	Belongs to the neuregulin family.	ErbB signaling pathway;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;PI3K events in ERBB4 signaling;SHC1 events in ERBB4 signaling;Nuclear signaling by ERBB4;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling	PE1	15
+NX_Q8WWG9	Potassium voltage-gated channel subfamily E member 4	221	23806	4.68	1	Membrane;Nucleus;Cytoskeleton	NA	Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.	NA	Belongs to the potassium channel KCNE family.	Phase 3 - rapid repolarisation;Phase 2 - plateau phase	PE1	2
+NX_Q8WWH4	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1	475	53458	5.6	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).	NA	NA	PIWI-interacting RNA (piRNA) biogenesis	PE1	7
+NX_Q8WWH5	Probable tRNA pseudouridine synthase 1	349	37253	8.44	0	Cytoplasmic vesicle;Cytosol;Nucleus;Cytoskeleton	NA	Pseudouridine synthase that catalyzes pseudouridylation of mRNAs (PubMed:28073919). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919).	NA	Belongs to the pseudouridine synthase TruB family.	NA	PE1	10
+NX_Q8WWI1	LIM domain only protein 7	1683	192696	8.34	0	Cytosol;Cytoskeleton	NA	NA	NA	NA	Adherens junction;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	13
+NX_Q8WWI5	Choline transporter-like protein 1	657	73302	8.93	9	Mitochondrion outer membrane;Nucleoplasm;Mitochondrion;Cell membrane	NA	Choline transporter. May be involved in membrane synthesis and myelin production.	NA	Belongs to the CTL (choline transporter-like) family.	Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Choline catabolism	PE1	9
+NX_Q8WWK9	Cytoskeleton-associated protein 2	683	76987	9.45	0	Cytosol;Spindle pole;Spindle;Cytoskeleton	NA	Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).	NA	Belongs to the CKAP2 family.	NA	PE1	13
+NX_Q8WWL2	Protein spire homolog 2	714	79671	7.75	0	Cell membrane;Nucleoplasm;Cytoplasmic vesicle membrane;Cytoplasmic vesicle;Cytosol;Cytoskeleton	NA	Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).	NA	Belongs to the spire family.	Dorso-ventral axis formation	PE1	16
+NX_Q8WWL7	G2/mitotic-specific cyclin-B3	1395	157916	6.28	0	Nucleus speckle;Nucleus	NA	Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.	Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1.	Belongs to the cyclin family. Cyclin AB subfamily.	Cell cycle;p53 signaling pathway;Progesterone-mediated oocyte maturation	PE1	X
+NX_Q8WWM1	X antigen family member 5	108	12077	4.81	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the GAGE family.	NA	PE2	X
+NX_Q8WWM7	Ataxin-2-like protein	1075	113374	8.7	0	Cytoplasm;Nucleus speckle;Membrane;Cytosol;Cytoplasmic granule	NA	Involved in the regulation of stress granule and P-body formation.	Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain.;Asymmetrically dimethylated. Probably methylated by PRMT1.	Belongs to the ataxin-2 family.	NA	PE1	16
+NX_Q8WWM9	Cytoglobin	190	21405	6.32	0	Cytoplasm;Cytosol;Nucleus speckle	NA	May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.	NA	Belongs to the globin family.	eNOS activation;Intracellular oxygen transport	PE1	17
+NX_Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	1544	169844	6.69	0	Cytoplasm;Cell membrane;Lamellipodium;Ruffle;Cytoskeleton	NA	Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.	Tyrosine phosphorylated at a low basal level. PDGF treatment stimulates phosphorylation. Tyrosine phosphorylation is increased in cells that are in the process of becoming attached to a substrate and that start spreading and flattening (By similarity).	NA	Endocytosis;Rho GTPase cycle	PE1	5
+NX_Q8WWN9	Interactor protein for cytohesin exchange factors 1	437	48993	7.17	0	Cytoplasm;Cell membrane	NA	Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.	NA	NA	NA	PE1	6
+NX_Q8WWP7	GTPase IMAP family member 1	306	34369	9.11	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity).	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.	NA	PE1	7
+NX_Q8WWQ0	PH-interacting protein	1821	206689	9.02	0	Nucleoplasm;Nucleus	Developmental delay, intellectual disability, obesity, and dysmorphic features	Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.	NA	NA	NA	PE1	6
+NX_Q8WWQ2	Inactive heparanase-2	592	66596	9.95	0	Extracellular matrix	Urofacial syndrome 1	Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).	NA	Belongs to the glycosyl hydrolase 79 family.	Glycosaminoglycan degradation;Metabolic pathways;HS-GAG degradation	PE1	10
+NX_Q8WWQ8	Stabilin-2	2551	276988	6	1	Cytoplasm;Cytosol;Cell membrane	NA	Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.	Proteolytically processed to yield a 190 kDa protein.;Glycosylated.	NA	Hyaluronan uptake and degradation;Scavenging by Class H Receptors	PE1	12
+NX_Q8WWR8	Sialidase-4	484	51572	7.97	0	Membrane;Lysosome lumen	NA	May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids.	According to PubMed:15213228, phosphorylation of mannose residues may ensure efficient transport of isoform 2 to the lysosomes via the mannose 6-phosphate receptor.;Is glycosylated.	Belongs to the glycosyl hydrolase 33 family.	Other glycan degradation;Sphingolipid metabolism;Sialic acid metabolism;Glycosphingolipid metabolism	PE1	2
+NX_Q8WWR9	Pancreatic progenitor cell differentiation and proliferation factor-like protein	84	9188	6.53	0	NA	NA	NA	NA	Belongs to the PPDPF family.	NA	PE1	8
+NX_Q8WWT9	Solute carrier family 13 member 3	602	66841	8.58	11	Cell membrane	Leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate	High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including succinate, alpha-ketoglutarate and N-acetylaspartate (PubMed:30635937). The stoichiometry is probably 3 Na(+) for 1 divalent succinate.	NA	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.	Sodium-coupled sulphate, di- and tri-carboxylate transporters	PE1	20
+NX_Q8WWU5	T-complex protein 11 homolog	503	56141	5.08	1	Membrane;Acrosome;Flagellum	NA	Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.	Constitutively phosphorylated on serine, threonine and tyrosine residues within the head and tail regions of noncapacitated spermatozoa. Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal region in a protein kinase A (PKA)-dependent signaling pathway.	Belongs to the TCP11 family.	NA	PE1	6
+NX_Q8WWU7	Intelectin-2	325	36212	8.61	0	Secreted	NA	May play a role in the defense system against pathogens.	NA	NA	NA	PE1	1
+NX_Q8WWV3	Reticulon-4-interacting protein 1, mitochondrial	396	43590	9.22	0	Mitochondrion outer membrane	Optic atrophy 10 with or without ataxia, mental retardation, and seizures	Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.	NA	PE1	6
+NX_Q8WWV6	High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor	532	57144	9.37	1	Cell membrane	NA	Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.	N-glycosylated.	NA	Cell surface interactions at the vascular wall	PE1	1
+NX_Q8WWW0	Ras association domain-containing protein 5	418	47090	9.31	0	Cytoplasm;Cytoskeleton	NA	Stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.;Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation.	RASSF5 is phosphorylated by LCK	NA	Leukocyte transendothelial migration;Pathways in cancer;Non-small cell lung cancer	PE1	1
+NX_Q8WWW8	GRB2-associated-binding protein 3	586	65589	6.8	0	NA	NA	NA	Phosphorylated on tyrosine residue(s) after macrophage colony-stimulating factor (M-CSF) receptor stimulation.	Belongs to the GAB family.	NA	PE1	X
+NX_Q8WWX0	Ankyrin repeat and SOCS box protein 5	329	36341	6.34	0	Cell membrane	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity).	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	4
+NX_Q8WWX8	Sodium/myo-inositol cotransporter 2	675	74036	6.33	14	Membrane;Nucleoplasm;Cytosol	NA	Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.	NA	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Inositol transporters	PE1	16
+NX_Q8WWX9	Selenoprotein M	145	16232	5.39	0	Golgi apparatus;Cytoplasm;Endoplasmic reticulum;Nucleoplasm;Cytosol;Perinuclear region;Nucleus	NA	May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.	NA	Belongs to the selenoprotein M/F family.	NA	PE1	22
+NX_Q8WWY3	U4/U6 small nuclear ribonucleoprotein Prp31	499	55456	5.63	0	Cajal body;Nucleoplasm;Nucleus speckle;Nucleus	Retinitis pigmentosa 11	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543).	NA	Belongs to the PRP31 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	19
+NX_Q8WWY6	Methyl-CpG-binding domain protein 3-like 1	194	21616	8.52	0	Nucleus	NA	Transcriptional repressor.	NA	Belongs to the MBD3L family.	NA	PE1	19
+NX_Q8WWY7	WAP four-disulfide core domain protein 12	111	12050	5.35	0	Secreted	NA	Antibacterial protein. Putative acid-stable proteinase inhibitor.	NA	NA	NA	PE1	20
+NX_Q8WWY8	Lipase member H	451	50859	7.15	0	Membrane;Secreted	Woolly hair autosomal recessive 2;Hypotrichosis 7	Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Synthesis of PA	PE1	3
+NX_Q8WWZ1	Interleukin-1 family member 10	152	16943	4.94	0	Secreted	NA	Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.	NA	Belongs to the IL-1 family.	Interleukin-36 pathway;Interleukin-38 signaling	PE1	2
+NX_Q8WWZ3	Ectodysplasin-A receptor-associated adapter protein	215	24802	5.23	0	Nucleoplasm;Cytosol;Cytoplasm	Ectodermal dysplasia 11B, hypohidrotic/hair/tooth type, autosomal recessive;Ectodermal dysplasia 11A, hypohidrotic/hair/nail type, autosomal dominant	Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B.	NA	NA	TNFs bind their physiological receptors	PE1	1
+NX_Q8WWZ4	ATP-binding cassette sub-family A member 10	1543	175790	6.22	15	Membrane	NA	Probable transporter which may play a role in macrophage lipid homeostasis.	NA	Belongs to the ABC transporter superfamily. ABCA family.	ABC transporters;ABC transporters in lipid homeostasis	PE2	17
+NX_Q8WWZ7	ATP-binding cassette sub-family A member 5	1642	186508	6.51	15	Nucleoplasm;Lysosome membrane;Late endosome membrane;Golgi apparatus membrane	NA	May play a role in the processing of autolysosomes.	N-glycosylated.	Belongs to the ABC transporter superfamily. ABCA family.	ABC transporters;ABC transporters in lipid homeostasis	PE1	17
+NX_Q8WWZ8	Oncoprotein-induced transcript 3 protein	545	60022	5.34	0	Nucleus envelope	NA	May be involved in hepatocellular function and development.	NA	NA	NA	PE1	10
+NX_Q8WX39	Epididymal-specific lipocalin-9	176	20285	5.72	0	Secreted	NA	NA	NA	Belongs to the calycin superfamily. Lipocalin family.	Transport of fatty acids	PE2	9
+NX_Q8WX77	Insulin-like growth factor-binding protein-like 1	278	29005	8.29	0	Cytoplasmic vesicle;Nucleoplasm;Secreted	NA	IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.	NA	NA	NA	PE1	9
+NX_Q8WX92	Negative elongation factor B	580	65697	5.77	0	Nucleoplasm;Nucleus	NA	(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II (PubMed:23884411). In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1 (PubMed:23884411).;Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity).	NA	Belongs to the NELF-B family.	Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes;NTRK3 as a dependence receptor	PE1	9
+NX_Q8WX93	Palladin	1383	150564	6.67	0	Axon;Cell membrane;Growth cone;Podosome;Focal adhesion;Lamellipodium;Ruffle;Cytosol;Z line;Cytoskeleton	Pancreatic cancer 1	Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci.	Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines (By similarity). Phosphorylation at Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility.	Belongs to the myotilin/palladin family.	NA	PE1	4
+NX_Q8WX94	NACHT, LRR and PYD domains-containing protein 7	980	111807	5.87	0	Golgi apparatus	Hydatidiform mole, recurrent, 1	Inhibits CASP1/caspase-1-dependent IL1B secretion.	NA	Belongs to the NLRP family.	NA	PE1	19
+NX_Q8WXA2	Prostate and testis expressed protein 1	126	14271	8.28	0	Secreted	NA	NA	NA	Belongs to the PATE family.	NA	PE1	11
+NX_Q8WXA3	RUN and FYVE domain-containing protein 2	606	70010	5.61	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	10
+NX_Q8WXA8	5-hydroxytryptamine receptor 3C	447	50220	5.59	4	Cell membrane	NA	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.	Neurotransmitter receptors and postsynaptic signal transmission	PE1	3
+NX_Q8WXA9	Splicing regulatory glutamine/lysine-rich protein 1	508	59380	10.39	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity).	NA	Belongs to the splicing factor SR family.	NA	PE1	5
+NX_Q8WXB1	Protein N-lysine methyltransferase METTL21A	218	24600	5.84	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.	NA	Belongs to the methyltransferase superfamily. METTL21 family.	Protein methylation	PE1	2
+NX_Q8WXB4	Zinc finger protein 606	792	91812	8.16	0	Nucleoplasm;Nucleus	NA	May act as a transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q8WXC3	Pyrin domain-containing protein 1	89	10107	6.3	0	Cytoplasm	NA	Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.	Phosphorylated.	NA	NOD-like receptor signaling pathway	PE1	16
+NX_Q8WXC6	COP9 signalosome complex subunit 9	57	6211	3.6	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.;Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.	NA	Belongs to the CSN9 family.	NA	PE1	2
+NX_Q8WXD0	Relaxin receptor 2	754	86453	9.04	7	Cell membrane	Cryptorchidism	Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Relaxin receptors;G alpha (s) signalling events	PE1	13
+NX_Q8WXD2	Secretogranin-3	468	53005	4.94	0	Cytoplasmic vesicle;Secretory vesicle membrane;Secreted;Secretory vesicle	NA	Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827).	O-glycosylated.	NA	Platelet degranulation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	15
+NX_Q8WXD5	Gem-associated protein 6	167	18824	5.02	0	Nucleoplasm;Cytoplasm;Gem;Nucleus	NA	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.	NA	NA	RNA transport;snRNP Assembly	PE1	2
+NX_Q8WXD9	Caskin-1	1431	149814	9.21	0	Nucleoplasm;Cytosol;Cytoplasm	NA	May link the scaffolding protein CASK to downstream intracellular effectors.	NA	NA	NA	PE1	16
+NX_Q8WXE0	Caskin-2	1202	126783	6.63	0	Cytoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	17
+NX_Q8WXE1	ATR-interacting protein	791	85838	5.9	0	Nucleoplasm;Nucleus	NA	Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.	Phosphorylated by ATR.	Belongs to the ATRIP family.	Fanconi anemia pathway;Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation	PE1	3
+NX_Q8WXE9	Stonin-2	905	101165	5.2	0	Cytoplasm;Synaptosome;Nucleolus;Membrane;Cytosol	NA	Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.	Neddylated; deneddylated via its interaction with the COP9 signalosome (CSN) complex through TOR1A and COPS4.;Phosphorylated in vitro by PKD.;Ubiquitinated; leading to its degradation.	Belongs to the Stoned B family.	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	14
+NX_Q8WXF0	Serine/arginine-rich splicing factor 12	261	30512	11.69	0	Nucleus	NA	Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.	NA	Belongs to the splicing factor SR family.	NA	PE1	6
+NX_Q8WXF1	Paraspeckle component 1	523	58744	6.26	0	Cytoplasm;Nucleus speckle;Nucleus matrix;Nucleolus;Nucleoplasm;Nucleus	NA	Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.	NA	Belongs to the PSPC family.	NA	PE1	13
+NX_Q8WXF3	Relaxin-3	142	15451	5.41	0	Secreted	NA	May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142).	NA	Belongs to the insulin family.	G alpha (i) signalling events;Relaxin receptors;G alpha (s) signalling events	PE1	19
+NX_Q8WXF5	Gamma-crystallin N	182	20624	5.4	0	NA	NA	NA	NA	Belongs to the beta/gamma-crystallin family.	NA	PE2	7
+NX_Q8WXF7	Atlastin-1	558	63544	5.82	2	Axon;Endoplasmic reticulum membrane;Golgi apparatus membrane	Spastic paraplegia 3, autosomal dominant;Neuropathy, hereditary sensory, 1D	GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:27619977). May also regulate Golgi biogenesis. May regulate axonal development.	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	NA	PE1	14
+NX_Q8WXF8	DNA-binding death effector domain-containing protein 2	326	36179	9.23	0	Nucleoplasm;Nucleolus	NA	May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.	NA	NA	NA	PE1	19
+NX_Q8WXG1	Radical S-adenosyl methionine domain-containing protein 2	361	42170	8.53	0	Mitochondrion outer membrane;Golgi apparatus;Endoplasmic reticulum membrane;Mitochondrion;Lipid droplet;Nucleolus;Endoplasmic reticulum;Mitochondrion inner membrane	NA	Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphosphate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.	NA	Belongs to the radical SAM superfamily. RSAD2 family.	Influenza A;Interferon alpha/beta signaling	PE1	2
+NX_Q8WXG6	MAP kinase-activating death domain protein	1647	183303	5.72	0	Membrane;Cytoplasm;Cytosol;Cell membrane	NA	Shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.;Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing.	MADD is phosphorylated by MAPK10 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the MADD family.	Regulation of TNFR1 signaling;RAB GEFs exchange GTP for GDP on RABs	PE1	11
+NX_Q8WXG8	Protein S100-Z	99	11620	7.73	0	NA	NA	NA	NA	Belongs to the S-100 family.	NA	PE1	5
+NX_Q8WXG9	Adhesion G-protein coupled receptor V1	6306	693069	4.53	7	Photoreceptor inner segment;Stereocilium membrane;Cell membrane;Lipid droplet	Febrile seizures, familial, 4;Usher syndrome 2C	Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stronger effect than full ADGRV1.;G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism.	Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	5
+NX_Q8WXH0	Nesprin-2	6885	796442	5.26	1	Nucleus outer membrane;Mitochondrion;Cell membrane;Focal adhesion;Nucleus membrane;Nucleoplasm;Sarcoplasmic reticulum membrane;Z line;Cytoskeleton	Emery-Dreifuss muscular dystrophy 5, autosomal dominant	Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis.	The disulfid bond with SUN2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction.	Belongs to the nesprin family.	Meiotic synapsis	PE1	14
+NX_Q8WXH2	Junctophilin-3	748	81469	9.43	1	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane;Cell membrane	Huntington disease-like 2	Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.	NA	Belongs to the junctophilin family.	NA	PE1	16
+NX_Q8WXH4	Ankyrin repeat and SOCS box protein 11	323	35367	8.39	0	NA	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	X
+NX_Q8WXH5	Suppressor of cytokine signaling 4	440	50623	6.63	0	Nucleoplasm;Cytosol	NA	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.	NA	NA	Protein modification; protein ubiquitination.;Jak-STAT signaling pathway;Insulin signaling pathway;Type II diabetes mellitus;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	PE1	14
+NX_Q8WXH6	Ras-related protein Rab-40A	277	31076	9.45	0	Cell membrane	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the small GTPase superfamily. Rab family.	Protein modification; protein ubiquitination.;RAB geranylgeranylation	PE2	X
+NX_Q8WXI2	Connector enhancer of kinase suppressor of ras 2	1034	117535	6.34	0	Membrane;Cytoplasm;Golgi apparatus;Cell membrane	Mental retardation, X-linked, syndromic, Houge type	May function as an adapter protein or regulator of Ras signaling pathways.	Phosphorylated on tyrosine.	Belongs to the CNKSR family.	MAP2K and MAPK activation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	X
+NX_Q8WXI3	Ankyrin repeat and SOCS box protein 10	467	50894	6.55	0	Cytoplasm;Nucleus	Glaucoma 1, open angle, F	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	7
+NX_Q8WXI4	Acyl-coenzyme A thioesterase 11	607	68492	8.66	0	Cytoplasm;Mitochondrion matrix;Cytosol	NA	Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway.	NA	NA	Lipid metabolism; fatty acid metabolism.;Mitochondrial Fatty Acid Beta-Oxidation	PE1	1
+NX_Q8WXI7	Mucin-16	14507	1519175	5.13	1	Extracellular space;Cell membrane	NA	Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.	Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.;Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.;May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.;May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	19
+NX_Q8WXI8	C-type lectin domain family 4 member D	215	24704	8.28	1	Membrane	NA	A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766). Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells (PubMed:14971047).	NA	NA	Dectin-2 family;Neutrophil degranulation	PE1	12
+NX_Q8WXI9	Transcriptional repressor p66-beta	593	65261	9.73	0	Nucleoplasm;Nucleus speckle	Mental retardation, autosomal dominant 18	Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.	NA	NA	RNA Polymerase I Transcription Initiation;HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;Regulation of PTEN gene transcription	PE1	1
+NX_Q8WXJ9	Ankyrin repeat and SOCS box protein 17	295	34282	9.05	0	NA	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	1
+NX_Q8WXK1	Ankyrin repeat and SOCS box protein 15	588	65799	5.51	0	NA	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE2	7
+NX_Q8WXK3	Ankyrin repeat and SOCS box protein 13	278	30007	6.36	0	Golgi apparatus;Nucleoplasm	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	10
+NX_Q8WXK4	Ankyrin repeat and SOCS box protein 12	309	33943	5.53	0	NA	NA	Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	X
+NX_Q8WXQ3	Putative uncharacterized protein encoded by LINC01599	324	35482	5.84	0	NA	NA	NA	NA	NA	NA	PE2	14
+NX_Q8WXQ8	Carboxypeptidase A5	436	49036	6.24	0	Nucleoplasm;Secreted	NA	NA	NA	Belongs to the peptidase M14 family.	NA	PE1	7
+NX_Q8WXR4	Myosin-IIIb	1341	151829	8.4	0	Stereocilium;Cytoskeleton	NA	Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments.	NA	In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.;In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	2
+NX_Q8WXS3	Brain and acute leukemia cytoplasmic protein	180	19224	5.47	0	Cytoplasm;Synaptosome;Nucleoplasm;Postsynaptic density;Cytosol;Membrane raft	NA	May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A.	Palmitoylation and myristoylation target the protein to the lipid rafts.	NA	NA	PE1	8
+NX_Q8WXS4	Voltage-dependent calcium channel gamma-like subunit	190	20932	7.65	4	Membrane;Nucleoplasm;Cytosol;Nucleolus	NA	Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).	NA	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	NA	PE1	2
+NX_Q8WXS5	Voltage-dependent calcium channel gamma-8 subunit	425	43313	9.34	5	Postsynaptic density;Cell membrane	NA	Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.	NA	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Trafficking of AMPA receptors;LGI-ADAM interactions;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	19
+NX_Q8WXS8	A disintegrin and metalloproteinase with thrombospondin motifs 14	1223	133888	6.81	0	Extracellular matrix	NA	Has aminoprocollagen type I processing activity in the absence of ADAMTS2 (PubMed:11741898). Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (PubMed:11741898). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form (PubMed:31152061).	The precursor is cleaved by a furin endopeptidase.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	O-glycosylation of TSR domain-containing proteins;Collagen biosynthesis and modifying enzymes;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	10
+NX_Q8WXT5	Forkhead box protein D4-like 4	416	45892	9.74	0	Nucleus	NA	NA	NA	NA	NA	PE2	9
+NX_Q8WXU2	Dynein assembly factor 4, axonemal	420	48527	8.88	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	Dyslexia 1;Ciliary dyskinesia, primary, 25	Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.	NA	NA	NA	PE1	15
+NX_Q8WXW3	Progesterone-induced-blocking factor 1	757	89805	5.78	0	Cytoplasm;Centriolar satellite;Secreted;Centrosome;Nucleus	Joubert syndrome 33	Plays a role in ciliogenesis.;Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806).;The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect (PubMed:14634107, PubMed:3863495, PubMed:12516630). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441).	NA	NA	NA	PE1	13
+NX_Q8WXX0	Dynein heavy chain 7, axonemal	4024	461159	5.7	0	Cytosol;Cilium axoneme	NA	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).	NA	Belongs to the dynein heavy chain family.	NA	PE1	2
+NX_Q8WXX5	DnaJ homolog subfamily C member 9	260	29910	5.58	0	Cytoplasm;Nucleoplasm;Nucleus;Cell membrane	NA	May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.	NA	NA	NA	PE1	10
+NX_Q8WXX7	Autism susceptibility gene 2 protein	1259	138982	9.41	0	Growth cone;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Mental retardation, autosomal dominant 26	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity).	NA	Belongs to the AUTS2 family.	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	7
+NX_Q8WY07	Cationic amino acid transporter 3	619	67169	5.82	14	Cell membrane	NA	Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.	N-glycosylated.	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.	Amino acid transport across the plasma membrane	PE1	X
+NX_Q8WY21	VPS10 domain-containing receptor SorCS1	1168	129635	7.38	1	Membrane;Cytosol;Cell membrane	NA	NA	O-glycosylated.	Belongs to the VPS10-related sortilin family. SORCS subfamily.	NA	PE1	10
+NX_Q8WY22	BRI3-binding protein	251	27836	9.48	4	Mitochondrion outer membrane;Nucleoplasm;Mitochondrion	NA	Involved in tumorigenesis and may function by stabilizing p53/TP53.	NA	NA	NA	PE1	12
+NX_Q8WY36	HMG box transcription factor BBX	941	105130	8.96	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor that is necessary for cell cycle progression from G1 to S phase.	NA	NA	NA	PE1	3
+NX_Q8WY41	Nanos homolog 1	292	30230	8.29	0	Nucleoplasm;Cytoplasm;Cytosol;Perinuclear region	Spermatogenic failure 12	May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.	NA	Belongs to the nanos family.	NA	PE1	10
+NX_Q8WY50	Placenta-specific protein 4	150	16680	7.02	0	NA	NA	NA	NA	NA	NA	PE2	21
+NX_Q8WY54	Protein phosphatase 1E	755	83952	4.93	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity).	NA	Belongs to the PP2C family.	Negative regulation of NMDA receptor-mediated neuronal transmission	PE1	17
+NX_Q8WY64	E3 ubiquitin-protein ligase MYLIP	445	49910	6.9	0	Cytoplasm;Cell membrane	NA	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.	Autoubiquitinated.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;VLDLR internalisation and degradation	PE1	6
+NX_Q8WY91	THAP domain-containing protein 4	577	62890	9.39	0	Nucleoplasm;Nucleus speckle	NA	NA	NA	NA	NA	PE1	2
+NX_Q8WY98	Transmembrane protein 234	164	17601	8.76	3	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the TMEM234 family.	NA	PE1	1
+NX_Q8WYA0	Intraflagellar transport protein 81 homolog	676	79746	8.9	0	Cytosol;Centrosome;Cilium	Short-rib thoracic dysplasia 19 with or without polydactyly	Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region (PubMed:23990561). Required for ciliogenesis (PubMed:27666822, PubMed:23990561). Required for proper regulation of SHH signaling (PubMed:27666822).	NA	Belongs to the IFT81 family.	Intraflagellar transport	PE1	12
+NX_Q8WYA1	Aryl hydrocarbon receptor nuclear translocator-like protein 2	636	70887	7.01	0	Nucleoplasm;Nucleolus;Nucleus	NA	Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1.	NA	NA	BMAL1:CLOCK,NPAS2 activates circadian gene expression	PE1	12
+NX_Q8WYA6	Beta-catenin-like protein 1	563	65173	4.96	0	Cytoplasm;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.	NA	NA	Spliceosome;mRNA Splicing - Major Pathway	PE1	20
+NX_Q8WYB5	Histone acetyltransferase KAT6B	2073	231378	5.68	0	Nucleoplasm;Nucleus	Genitopatellar syndrome;Ohdo syndrome, SBBYS variant	Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.	Autoacetylated (PubMed:10497217 and PubMed:11965546). Autoacetylation at Lys-815 is required for proper function.	Belongs to the MYST (SAS/MOZ) family.	HATs acetylate histones	PE1	10
+NX_Q8WYH8	Inhibitor of growth protein 5	240	27751	7.53	0	Nucleus	NA	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715).	NA	Belongs to the ING family.	HATs acetylate histones;Regulation of TP53 Activity through Acetylation	PE1	2
+NX_Q8WYJ6	Septin-1	367	41971	5.56	0	Cytoplasm;Centrosome;Midbody;Cytoskeleton	NA	Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	Bacterial invasion of epithelial cells	PE1	16
+NX_Q8WYK0	Acetyl-coenzyme A thioesterase	555	62034	6.3	0	Nucleoplasm;Cytosol	NA	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16951743). Acyl-coenzyme A thioesterase 12/ACOT12 preferentially hydrolyzes acetyl-CoA (PubMed:16951743).	NA	NA	Lipid metabolism; fatty acid metabolism.;Pyruvate metabolism;Mitochondrial Fatty Acid Beta-Oxidation	PE1	5
+NX_Q8WYK1	Contactin-associated protein-like 5	1306	145623	5.86	1	Membrane;Nucleoplasm;Nucleolus;Cytoplasmic vesicle	NA	May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.	NA	Belongs to the neurexin family.	NA	PE1	2
+NX_Q8WYK2	Jun dimerization protein 2	163	18704	9.3	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.	Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.;Polyubiquitinated; probably by IRF2BP1.	Belongs to the bZIP family. ATF subfamily.	NA	PE1	14
+NX_Q8WYL5	Protein phosphatase Slingshot homolog 1	1049	115511	5.87	0	Cleavage furrow;Cell membrane;Nucleoplasm;Lamellipodium;Cytosol;Midbody;Cytoskeleton	NA	Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.	Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.;SSH1 is phosphorylated by PAK4 (Phosphoserine:PTM-0253)	Belongs to the protein-tyrosine phosphatase family.	Regulation of actin cytoskeleton	PE1	12
+NX_Q8WYN0	Cysteine protease ATG4A	398	45378	4.93	0	Cytoplasm;Cytoskeleton	NA	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.	NA	Belongs to the peptidase C54 family.	Regulation of autophagy;Macroautophagy	PE1	X
+NX_Q8WYN3	Cysteine/serine-rich nuclear protein 3	585	64900	4.68	0	Nucleoplasm;Nucleolus;Nucleus	NA	Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis (By similarity).	NA	Belongs to the AXUD1 family.	NA	PE1	2
+NX_Q8WYP3	Ras and Rab interactor 2	895	100163	6.15	0	Golgi apparatus;Cytoplasm;Cytosol;Nucleolus	MACS syndrome	Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP.	NA	Belongs to the RIN (Ras interaction/interference) family.	RAB GEFs exchange GTP for GDP on RABs	PE1	20
+NX_Q8WYP5	Protein ELYS	2266	252498	6.19	0	Cytoplasm;Nuclear pore complex;Nucleus matrix;Nucleus membrane;Nucleoplasm;Nucleus envelope;Nucleus;Kinetochore	NA	Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.	NA	Belongs to the ELYS family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	1
+NX_Q8WYQ3	Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial	142	14149	7.73	0	Cytoplasm;Mitochondrion intermembrane space;Mitochondrion	Myopathy, isolated mitochondrial, autosomal dominant;Spinal muscular atrophy, Jokela type;Frontotemporal dementia and/or amyotrophic lateral sclerosis 2	May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure.	NA	NA	Mitochondrial protein import	PE1	22
+NX_Q8WYQ4	Uncharacterized protein C22orf15	148	16487	9.03	0	NA	NA	NA	NA	NA	NA	PE1	22
+NX_Q8WYQ5	Microprocessor complex subunit DGCR8	773	86045	5.68	0	Nucleolus;Nucleus	NA	Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity).	NA	NA	MicroRNA (miRNA) biogenesis;Transcriptional Regulation by MECP2	PE1	22
+NX_Q8WYQ9	Zinc finger CCHC domain-containing protein 14	949	100042	8.47	0	Nucleus membrane	NA	NA	NA	NA	NA	PE1	16
+NX_Q8WYR1	Phosphoinositide 3-kinase regulatory subunit 5	880	97348	6.3	0	Cytoplasm;Cell membrane;Centriolar satellite;Cytosol;Nucleus	Ataxia-oculomotor apraxia 3	Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).	NA	NA	ErbB signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;mTOR signaling pathway;Apoptosis;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Cholinergic synapse;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Carbohydrate digestion and absorption;Bacterial invasion of epithelial cells;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Synthesis of PIPs at the plasma membrane;GPVI-mediated activation cascade;G beta:gamma signalling through PI3Kgamma;Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	PE1	17
+NX_Q8WYR4	Radial spoke head 1 homolog	309	35124	4.58	0	Cytoplasm;Centrosome;Cilium	Ciliary dyskinesia, primary, 24	May play an important role in male meiosis (By similarity). It is necessary for proper building of the axonemal central pair and radial spokes.	NA	NA	NA	PE1	21
+NX_Q8WZ04	Transmembrane O-methyltransferase	291	32155	9.3	1	Membrane;Endoplasmic reticulum;Cytoplasm	Deafness, autosomal recessive, 63	Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (PubMed:18794526). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.	Enzymatic degradation of dopamine by COMT	PE1	11
+NX_Q8WZ19	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1	329	36357	6.77	0	Nucleoplasm;Nucleus	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity).	NA	Belongs to the BACURD family.	Protein modification; protein ubiquitination.	PE1	16
+NX_Q8WZ26	Putative uncharacterized protein PP6455	134	14832	8.26	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_Q8WZ33	MaFF-interacting protein	124	13947	7.7	0	Cytoplasm;Nucleolus	NA	Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency.	NA	Belongs to the tektin family.	NA	PE1	4
+NX_Q8WZ42	Titin	34350	3816030	6.02	0	Cytoplasm;Nucleus	Cardiomyopathy, familial hypertrophic 9;Tardive tibial muscular dystrophy;Myopathy, myofibrillar, 9, with early respiratory failure;Muscular dystrophy, limb-girdle, autosomal recessive 10;Salih myopathy;Cardiomyopathy, dilated 1G	Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.	Autophosphorylated.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	Platelet degranulation;Striated Muscle Contraction	PE1	2
+NX_Q8WZ55	Barttin	320	35197	4.24	2	Cytoplasm;Cell membrane	Bartter syndrome 4A, neonatal, with sensorineural deafness	Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.	Palmitoylation is necessary for activation of plasma membrane-inserted CLC-K/barttin channels.	NA	Stimuli-sensing channels	PE1	1
+NX_Q8WZ59	Transmembrane protein 190	177	19457	5.15	1	Membrane	NA	NA	NA	NA	NA	PE1	19
+NX_Q8WZ60	Kelch-like protein 6	621	70359	5.89	0	Spindle;Centriolar satellite;Cell membrane;Cytoskeleton	NA	Involved in B-lymphocyte antigen receptor signaling and germinal center formation.	NA	NA	NA	PE1	3
+NX_Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	1704	193452	7.11	0	Cytoplasm;Focal adhesion;Cytoskeleton	NA	Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).	NA	NA	Endocytosis;Rho GTPase cycle	PE1	4
+NX_Q8WZ69	Putative uncharacterized protein C11orf40	217	24620	7.61	0	NA	NA	NA	NA	NA	NA	PE2	11
+NX_Q8WZ71	Transmembrane protein 158	300	30404	8.74	2	Membrane	NA	Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.	N-glycosylated.	Belongs to the TMEM158 family.	NA	PE1	3
+NX_Q8WZ73	E3 ubiquitin-protein ligase rififylin	363	40514	5.33	0	Cytoplasmic vesicle;Cytosol;Recycling endosome membrane;Cell membrane	NA	E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.	Undergoes caspase-mediated cleavage upon death-receptor activation, by TNFSF10 for instance. May be mediated by the caspases CASP8 and CASP10 in a negative feedback loop.;Palmitoylated.;Autoubiquitinated.	NA	Protein modification; protein ubiquitination.;Regulation of TP53 Degradation	PE1	17
+NX_Q8WZ74	Cortactin-binding protein 2	1663	181051	8.23	0	Cytosol;Dendritic spine;Cell cortex;Midbody ring	NA	Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.	NA	NA	NA	PE1	7
+NX_Q8WZ75	Roundabout homolog 4	1007	107457	6.18	0	Cell membrane	NA	Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).	NA	Belongs to the immunoglobulin superfamily. ROBO family.	NA	PE1	11
+NX_Q8WZ79	Deoxyribonuclease-2-beta	361	41713	9.4	0	Lysosome	NA	Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.	NA	Belongs to the DNase II family.	Lysosome	PE2	1
+NX_Q8WZ82	Esterase OVCA2	227	24418	6.44	0	Nucleoplasm;Cytosol	NA	NA	Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.	Belongs to the LovG family.	NA	PE1	17
+NX_Q8WZ84	Olfactory receptor 8D1	308	34445	8.7	7	Cell membrane	NA	Odorant receptor (Potential). May be involved in taste perception.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8WZ92	Olfactory receptor 5P2	322	35786	8.01	7	Cell membrane	NA	Odorant receptor (Potential). May be involved in taste perception.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8WZ94	Olfactory receptor 5P3	311	34296	8.67	7	Cell membrane	NA	Odorant receptor (Potential). May be involved in taste perception.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q8WZA0	Protein LZIC	190	21495	4.88	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the CTNNBIP1 family.	NA	PE1	1
+NX_Q8WZA1	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	660	75252	6.37	1	Golgi apparatus membrane	Retinitis pigmentosa 76;Muscular dystrophy-dystroglycanopathy limb-girdle C3;Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A3;Muscular dystrophy-dystroglycanopathy congenital with mental retardation B3	Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins (PubMed:11709191, PubMed:27493216, PubMed:28512129). Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties (PubMed:11709191, PubMed:27493216). Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity.	NA	Belongs to the glycosyltransferase 13 family.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;O-linked glycosylation;Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	PE1	1
+NX_Q8WZA2	Rap guanine nucleotide exchange factor 4	1011	115522	6.37	0	Membrane;Cytoplasm;Focal adhesion	NA	Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).	NA	NA	Leukocyte transendothelial migration;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Integrin alphaIIb beta3 signaling;Regulation of insulin secretion;Rap1 signalling	PE1	2
+NX_Q8WZA6	Olfactory receptor 1E3	343	38518	8.85	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	17
+NX_Q8WZA8	Putative gastric cancer-related gene 224 protein	35	3819	7.96	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q8WZA9	Immunity-related GTPase family Q protein	623	62717	4.81	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.	NA	PE1	19
+NX_Q8WZB0	Putative uncharacterized protein encoded by LINC00476	136	14715	11.93	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_Q902F8	Endogenous retrovirus group K member 8 Env polyprotein	699	79168	9.26	1	Virion;Cell membrane	NA	TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).;SU mediates receptor recognition.;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.	NA	PE1	8
+NX_Q902F9	Endogenous retrovirus group K member 113 Env polyprotein	699	79195	9.06	1	Virion;Cell membrane	NA	TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.;SU mediates receptor recognition.	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.	NA	PE1	19
+NX_Q92185	Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase	356	40519	9.41	1	Golgi apparatus membrane	NA	Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid.	NA	Belongs to the glycosyltransferase 29 family.	Lipid metabolism; sphingolipid metabolism.;Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Glycosphingolipid biosynthesis - globo series;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Sialic acid metabolism	PE1	12
+NX_Q92186	Alpha-2,8-sialyltransferase 8B	375	42430	9.48	1	Centriolar satellite;Golgi apparatus membrane	NA	May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.	NA	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Sialic acid metabolism;NCAM1 interactions;N-Glycan antennae elongation	PE1	15
+NX_Q92187	CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase	359	41295	9.77	1	Golgi apparatus;Golgi apparatus membrane	NA	Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.	NA	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Sialic acid metabolism;NCAM1 interactions	PE1	5
+NX_Q92466	DNA damage-binding protein 2	427	47864	9.56	0	Nucleoplasm;Cell junction;Nucleus	Xeroderma pigmentosum complementation group E	Inhibit UV-damaged DNA repair.;Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER.	Ubiquitinated, leading to proteasomal degradation, and deubiquitinated by USP24.;Phosphorylation by ABL1 negatively regulate UV-DDB activity.;Ubiquitinated by CUL4A in response to UV irradiation. Ubiquitination appears to both impair DNA-binding and promotes ubiquitin-dependent proteolysis. Degradation of DDB2 at sites of DNA damage may be a prerequisite for their recognition by XPC and subsequent repair. CUL4A-mediated degradation appears to be promoted by ABL1.;DDB2 is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	Belongs to the WD repeat DDB2/WDR76 family.	Protein modification; protein ubiquitination.;Nucleotide excision repair;p53 signaling pathway;Ubiquitin mediated proteolysis;DNA Damage Recognition in GG-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;TP53 Regulates Transcription of DNA Repair Genes;Ub-specific processing proteases;Neddylation	PE1	11
+NX_Q92478	C-type lectin domain family 2 member B	149	17307	9.02	1	Membrane	NA	NA	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	12
+NX_Q92481	Transcription factor AP-2-beta	460	50474	8.41	0	Nucleoplasm;Nucleus	Char syndrome;Patent ductus arteriosus 2	Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.	Sumoylated on Lys-21; which inhibits transcriptional activity.	Belongs to the AP-2 family.	SUMOylation of transcription factors;Activation of the TFAP2 (AP-2) family of transcription factors;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors	PE1	6
+NX_Q92482	Aquaporin-3	292	31544	6.74	6	Nucleoplasm;Basolateral cell membrane;Cell membrane	NA	Water channel required to promote glycerol permeability and water transport across cell membranes (PubMed:12239222, PubMed:30420639). Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family.	Vasopressin-regulated water reabsorption;Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins	PE1	9
+NX_Q92484	Acid sphingomyelinase-like phosphodiesterase 3a	453	51260	5.88	0	Nucleoplasm;Mitochondrion;Secreted;Nucleolus	NA	Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088). Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (PubMed:25288789, PubMed:26783088). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine (PubMed:26783088). Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088).	N-glycosylated.	Belongs to the acid sphingomyelinase family.	NA	PE1	6
+NX_Q92485	Acid sphingomyelinase-like phosphodiesterase 3b	455	50814	5.36	0	Golgi apparatus;Cytosol;Secreted;Cell membrane	NA	Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity).	N-glycosylated.	Belongs to the acid sphingomyelinase family.	NA	PE1	1
+NX_Q92496	Complement factor H-related protein 4	578	65351	4.85	0	Secreted	NA	Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.	Glycosylated.	NA	Regulation of Complement cascade	PE1	1
+NX_Q92499	ATP-dependent RNA helicase DDX1	740	82432	6.8	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Cytoplasmic granule;Nucleus	NA	(Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs.;(Microbial infection) Required for Coronavirus IBV replication.;Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity).	Phosphorylated by ATM kinase; phosphorylation is increased in response to ionizing radiation (IR).	Belongs to the DEAD box helicase family. DDX1 subfamily.	tRNA processing in the nucleus	PE1	2
+NX_Q92502	StAR-related lipid transfer protein 8	1023	112601	5.87	0	Focal adhesion	NA	Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1.	NA	NA	Rho GTPase cycle	PE1	X
+NX_Q92503	SEC14-like protein 1	715	81250	6.01	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol;Nucleus	NA	May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608).	NA	NA	NA	PE1	17
+NX_Q92504	Zinc transporter SLC39A7	469	50118	6.36	6	Endoplasmic reticulum;cis-Golgi network membrane;Endoplasmic reticulum membrane	NA	Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).	Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release.	Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.	Zinc influx into cells by the SLC39 gene family	PE1	6
+NX_Q92506	Estradiol 17-beta-dehydrogenase 8	261	26974	6.09	0	Mitochondrion matrix	NA	NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863). The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Lipid metabolism; fatty acid biosynthesis.;Steroid biosynthesis; estrogen biosynthesis.;Steroid hormone biosynthesis;Metabolic pathways;Fatty acyl-CoA biosynthesis	PE1	6
+NX_Q92508	Piezo-type mechanosensitive ion channel component 1	2521	286790	7.37	36	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane;Lamellipodium membrane;Cell membrane	Lymphatic malformation 6;Dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema	Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).	NA	Belongs to the PIEZO (TC 1.A.75) family.	NA	PE1	16
+NX_Q92519	Tribbles homolog 2	343	38801	5.77	0	Nucleoplasm;Cytoplasm;Cytosol;Cytoskeleton	NA	Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.	NA	PE1	2
+NX_Q92520	Protein FAM3C	227	24680	8.52	0	Golgi apparatus;Secreted;Cytoplasmic vesicle	NA	May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.	NA	Belongs to the FAM3 family.	Platelet degranulation	PE1	7
+NX_Q92521	GPI mannosyltransferase 3	554	65056	9.39	9	Cytosol;Endoplasmic reticulum membrane;Cell membrane	NA	Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.	NA	Belongs to the glycosyltransferase 22 family. PIGB subfamily.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	15
+NX_Q92522	Histone H1x	213	22487	10.76	0	Nucleoplasm;Nucleolus;Nucleus;Chromosome	NA	Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.	Citrullination at Arg-62 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.	Belongs to the histone H1/H5 family.	NA	PE1	3
+NX_Q92523	Carnitine O-palmitoyltransferase 1, muscle isoform	772	87801	8.86	2	Mitochondrion outer membrane	NA	NA	NA	Belongs to the carnitine/choline acetyltransferase family.	Lipid metabolism; fatty acid beta-oxidation.;Fatty acid metabolism;PPAR signaling pathway;Adipocytokine signaling pathway;Signaling by Retinoic Acid;Import of palmitoyl-CoA into the mitochondrial matrix	PE1	22
+NX_Q92526	T-complex protein 1 subunit zeta-2	530	57821	6.85	0	Cytoplasm	NA	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.	NA	Belongs to the TCP-1 chaperonin family.	Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	17
+NX_Q92527	Ankyrin repeat domain-containing protein 7	254	29029	9.09	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	7
+NX_Q92529	SHC-transforming protein 3	594	64056	8.57	0	Nucleoplasm	NA	Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.	Tyrosine phosphorylated.	NA	ErbB signaling pathway;Chemokine signaling pathway;Focal adhesion;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Insulin signaling pathway;Bacterial invasion of epithelial cells;Glioma;Chronic myeloid leukemia;RAF/MAP kinase cascade;Signalling to RAS;RET signaling	PE1	9
+NX_Q92530	Proteasome inhibitor PI31 subunit	271	29817	5.42	0	Endoplasmic reticulum;Cytoplasm;Cytosol	NA	Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.	NA	Belongs to the proteasome inhibitor PI31 family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	20
+NX_Q92535	Phosphatidylinositol N-acetylglucosaminyltransferase subunit C	297	33583	8.66	8	Endoplasmic reticulum membrane	Glycosylphosphatidylinositol biosynthesis defect 16	Involved in GPI anchor biosynthesis (PubMed:8806613, PubMed:27694521). Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis (ECO:0000269|PubMed:27694521).	NA	Belongs to the PIGC family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	1
+NX_Q92536	Y+L amino acid transporter 2	515	56828	5.63	12	Cytoplasmic vesicle;Basolateral cell membrane;Cell membrane	NA	Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.	Amino acid transport across the plasma membrane;Basigin interactions	PE1	16
+NX_Q92537	Sushi domain-containing protein 6	303	32090	5.01	1	Membrane;Nucleoplasm;Cytoskeleton	NA	May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).	NA	NA	NA	PE1	14
+NX_Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	1859	206446	5.48	0	trans-Golgi network;Cytoplasm;Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment;Lipid droplet;Membrane;cis-Golgi network	NA	Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:12047556, PubMed:12808027, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891).	AMPK-mediated phosphorylation at Thr-1337 is induced by 2-deoxyglucose (2-DG) and AICA ribonucleotide, and occurs during mitosis leading to membrane disassociation and inactivation of ARF1 during mitosis.	NA	VxPx cargo-targeting to cilium;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;trans-Golgi Network Vesicle Budding	PE1	10
+NX_Q92539	Phosphatidate phosphatase LPIN2	896	99399	5.18	0	Endoplasmic reticulum membrane;Cell membrane;Cytosol;Nucleus;Cytoskeleton	Majeed syndrome	Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity).	NA	Belongs to the lipin family.	Synthesis of PC;Synthesis of PE;Triglyceride biosynthesis;Depolymerisation of the Nuclear Lamina	PE1	18
+NX_Q92540	Protein SMG7	1137	127282	8.87	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.	NA	NA	mRNA surveillance pathway;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PE1	1
+NX_Q92541	RNA polymerase-associated protein RTF1 homolog	710	80313	8.21	0	Nucleoplasm;Cytosol	NA	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity).	NA	NA	Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins	PE1	15
+NX_Q92542	Nicastrin	709	78411	5.67	1	Membrane;Cytoplasmic vesicle membrane;Cytosol;Melanosome	Acne inversa, familial, 1	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.	N-glycosylated.	Belongs to the nicastrin family.	Notch signaling pathway;Alzheimer's disease;Degradation of the extracellular matrix;EPH-ephrin mediated repulsion of cells;Amyloid fiber formation;Nuclear signaling by ERBB4;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Regulated proteolysis of p75NTR;NOTCH2 Activation and Transmission of Signal to the Nucleus;NRIF signals cell death from the nucleus;Neutrophil degranulation;NOTCH3 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3;NOTCH4 Activation and Transmission of Signal to the Nucleus	PE1	1
+NX_Q92543	Sorting nexin-19	992	108598	4.97	0	Early endosome membrane;Cytoplasmic vesicle membrane;Mitochondrion	NA	Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).	NA	Belongs to the sorting nexin family.	NA	PE1	11
+NX_Q92544	Transmembrane 9 superfamily member 4	642	74519	6.11	9	Membrane;Golgi apparatus;Early endosome	NA	Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).	NA	Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	NA	PE1	20
+NX_Q92545	Transmembrane protein 131	1883	205138	8.74	2	Membrane;Cytoplasmic vesicle;Cytoskeleton	NA	May play a role in the immune response to viral infection.	NA	Belongs to the TMEM131 family.	NA	PE1	2
+NX_Q92546	RAB6A-GEF complex partner protein 2	391	42455	5.65	0	Membrane;Cytosol;Cell membrane	NA	The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.	NA	Belongs to the RGP1 family.	Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network;RAB GEFs exchange GTP for GDP on RABs	PE1	9
+NX_Q92547	DNA topoisomerase 2-binding protein 1	1522	170679	6.52	0	Chromosome;Nucleoplasm;Spindle pole;Centrosome;Nucleus	NA	Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042).	Phosphorylated on serine and threonine residues in response to X-ray irradiation.;Ubiquitinated and degraded by the proteasome. X-ray irradiation reduces ubiquitination.	NA	G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	3
+NX_Q92551	Inositol hexakisphosphate kinase 1	441	50236	6.81	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.	NA	Belongs to the inositol phosphokinase (IPK) family.	Synthesis of IPs in the nucleus;Synthesis of pyrophosphates in the cytosol	PE1	3
+NX_Q92552	28S ribosomal protein S27, mitochondrial	414	47611	5.83	0	Cytoplasm;Mitochondrion;Cell membrane;Nucleolus;Nucleoplasm	NA	RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715). Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366).	NA	Belongs to the mitochondrion-specific ribosomal protein mS27 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	5
+NX_Q92556	Engulfment and cell motility protein 1	727	83829	5.89	0	Cytoplasm;Cell membrane	NA	Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.	Phosphorylated by HCK.	NA	Chemokine signaling pathway;Bacterial invasion of epithelial cells;Shigellosis;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;Nef and signal transduction;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	PE1	7
+NX_Q92558	Wiskott-Aldrich syndrome protein family member 1	559	61652	6.01	0	Focal adhesion;Synapse;Cytoskeleton	NA	Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).	Phosphorylated on tyrosine residues by ABL1 and dephosphorylated by PTPN12.	Belongs to the SCAR/WAVE family.	Adherens junction;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Shigellosis;Salmonella infection;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;VEGFA-VEGFR2 Pathway	PE1	6
+NX_Q92560	Ubiquitin carboxyl-terminal hydrolase BAP1	729	80362	6.38	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Mesothelioma, malignant;Tumor predisposition syndrome	Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922). Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:25451922). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor (PubMed:9528852).	Ubiquitinated: monoubiquitinated at multiple site of its nuclear localization signal (NLS) BY UBE2O, leading to cytoplasmic retention. Able to mediate autodeubiquitination via intramolecular interactions to couteract cytoplasmic retention.	Belongs to the peptidase C12 family. BAP1 subfamily.	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;UCH proteinases	PE1	3
+NX_Q92561	Phytanoyl-CoA hydroxylase-interacting protein	330	37573	6.53	0	Nucleoplasm;Mitochondrion	NA	Its interaction with PHYH suggests a role in the development of the central system.	NA	Belongs to the PHYHIP family.	NA	PE1	8
+NX_Q92562	Polyphosphoinositide phosphatase	907	103635	6.46	0	Cytoplasmic vesicle;Lipid droplet;Endosome membrane	Yunis-Varon syndrome;Amyotrophic lateral sclerosis 11;Charcot-Marie-Tooth disease 4J;Polymicrogyria, bilateral temporooccipital	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.	NA	NA	Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane	PE1	6
+NX_Q92563	Testican-2	424	46779	4.71	0	Extracellular matrix	NA	May participate in diverse steps of neurogenesis. Binds calcium.	Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.	NA	NA	PE1	10
+NX_Q92564	DCN1-like protein 4	292	34068	5.58	0	Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	NA	Neddylation	PE1	4
+NX_Q92565	Rap guanine nucleotide exchange factor 5	580	67733	5.89	0	Nucleoplasm;Nucleus	NA	Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.	NA	NA	NA	PE1	7
+NX_Q92567	Protein FAM168A	244	26184	9.01	0	Nucleoplasm	NA	In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.	NA	Belongs to the FAM168 family.	NA	PE1	11
+NX_Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma	461	54448	5.68	0	Nucleoplasm;Cytoplasmic vesicle	NA	Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.	NA	Belongs to the PI3K p85 subunit family.	ErbB signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;mTOR signaling pathway;Apoptosis;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Cholinergic synapse;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Carbohydrate digestion and absorption;Bacterial invasion of epithelial cells;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;G alpha (q) signalling events;Synthesis of PIPs at the plasma membrane;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;GPVI-mediated activation cascade;Interleukin-7 signaling;Interleukin receptor SHC signaling;CD28 dependent PI3K/Akt signaling;Signaling by SCF-KIT;Interleukin-3, Interleukin-5 and GM-CSF signaling;Regulation of signaling by CBL;Costimulation by the CD28 family;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;Extra-nuclear estrogen signaling	PE1	1
+NX_Q92570	Nuclear receptor subfamily 4 group A member 3	626	68230	8	0	Nucleus	Ewing sarcoma	Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Plays also a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity).	Phosphorylated by PRKDC.	Belongs to the nuclear hormone receptor family. NR4 subfamily.	Nuclear Receptor transcription pathway;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	9
+NX_Q92572	AP-3 complex subunit sigma-1	193	21732	5.23	0	Golgi apparatus;Cytoplasmic vesicle membrane	NA	Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.	NA	Belongs to the adaptor complexes small subunit family.	Lysosome;Golgi Associated Vesicle Biogenesis	PE1	5
+NX_Q92574	Hamartin	1164	129767	6.02	0	Membrane;Cytoplasm;Cytosol	Tuberous sclerosis 1;Lymphangioleiomyomatosis;Focal cortical dysplasia 2	In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Seems not to be required for TSC2 GAP activity towards RHEB (PubMed:15340059). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155).	Phosphorylation at Ser-505 does not affect interaction with TSC2.	NA	mTOR signaling pathway;Insulin signaling pathway;Macroautophagy;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;Inhibition of TSC complex formation by PKB;TBC/RABGAPs	PE1	9
+NX_Q92575	UBX domain-containing protein 4	508	56778	6.1	0	Endoplasmic reticulum;Endoplasmic reticulum membrane;Nucleus envelope	NA	Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).	NA	NA	NA	PE1	2
+NX_Q92576	PHD finger protein 3	2039	229481	6.52	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	6
+NX_Q92581	Sodium/hydrogen exchanger 6	669	74162	6.03	13	Cytoplasmic vesicle;Endosome membrane	Mental retardation, X-linked, syndromic, Christianson type	Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.	NA	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Cardiac muscle contraction;Sodium/Proton exchangers;Defective SLC9A6 causes X-linked, syndromic mental retardation, Christianson type (MRXSCH)	PE1	X
+NX_Q92583	C-C motif chemokine 17	94	10507	9.59	0	Secreted	NA	Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway	PE1	16
+NX_Q92585	Mastermind-like protein 1	1016	108054	8.45	0	Nucleoplasm;Nucleus speckle	NA	Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.	NA	Belongs to the mastermind family.	Notch signaling pathway;Pre-NOTCH Transcription and Translation;Notch-HLH transcription pathway;NOTCH2 intracellular domain regulates transcription;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE1	5
+NX_Q92597	Protein NDRG1	394	42835	5.49	0	Cell membrane;Centrosome;Cytosol;Nucleus;Cytoskeleton	Charcot-Marie-Tooth disease 4D	Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.	Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent.	Belongs to the NDRG family.	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	PE1	8
+NX_Q92598	Heat shock protein 105 kDa	858	96865	5.28	0	Nucleoplasm;Cytoplasm;Cytosol	NA	Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).	Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.	Belongs to the heat shock protein 70 family.	Protein processing in endoplasmic reticulum;Regulation of HSF1-mediated heat shock response;Scavenging by Class F Receptors	PE1	13
+NX_Q92599	Septin-8	483	55756	5.89	0	Cytoplasm;Presynapse;Synaptic vesicle membrane;Synapse;Axon;Cytoskeleton	NA	Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP.;Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity).	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	NA	PE1	5
+NX_Q92600	CCR4-NOT transcription complex subunit 9	299	33631	8.18	0	Cytosol;P-body;Nucleus	NA	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.	NA	Belongs to the CNOT9 family.	RNA degradation;Deadenylation of mRNA;Activation of anterior HOX genes in hindbrain development during early embryogenesis;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	2
+NX_Q92604	Acyl-CoA:lysophosphatidylglycerol acyltransferase 1	370	43089	9.02	2	Endoplasmic reticulum membrane	NA	Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor.	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Glycerophospholipid metabolism;Acyl chain remodelling of PG	PE1	1
+NX_Q92608	Dedicator of cytokinesis protein 2	1830	211948	6.43	0	Endomembrane system;Cytoskeleton	Immunodeficiency 40	Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.	NA	Belongs to the DOCK family.	Chemokine signaling pathway;Fc gamma R-mediated phagocytosis;Factors involved in megakaryocyte development and platelet production;Nef and signal transduction;Neutrophil degranulation	PE1	5
+NX_Q92609	TBC1 domain family member 5	795	89004	6.1	0	Cytoplasmic vesicle;Golgi apparatus;Autophagosome;Endosome membrane	NA	May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492).	NA	NA	NA	PE1	3
+NX_Q92610	Zinc finger protein 592	1267	137528	8.1	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	15
+NX_Q92611	ER degradation-enhancing alpha-mannosidase-like protein 1	657	73768	6.45	1	Endoplasmic reticulum;Cytosol;Endoplasmic reticulum membrane	NA	Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.	NA	Belongs to the glycosyl hydrolase 47 family.	Protein processing in endoplasmic reticulum;XBP1(S) activates chaperone genes;ER Quality Control Compartment (ERQC)	PE1	3
+NX_Q92613	Protein Jade-3	823	93808	6.79	0	Nucleoplasm;Nucleolus	NA	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.	NA	Belongs to the JADE family.	HATs acetylate histones	PE1	X
+NX_Q92614	Unconventional myosin-XVIIIa	2054	233115	5.95	0	trans-Golgi network;Golgi apparatus;Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Cell surface;Cytoskeleton	NA	May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Signaling by FGFR1 in disease;Signaling by cytosolic FGFR1 fusion mutants	PE1	17
+NX_Q92615	La-related protein 4B	738	80552	6.48	0	Cytosol	NA	Stimulates mRNA translation.	NA	NA	NA	PE1	10
+NX_Q92616	eIF-2-alpha kinase activator GCN1	2671	292758	7.29	0	Cytoplasm;Cytosol	NA	Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.	NA	Belongs to the GCN1 family.	NA	PE1	12
+NX_Q92617	Nuclear pore complex-interacting protein family member B3	1050	116847	10.04	1	Membrane	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_Q92618	Zinc finger protein 516	1163	124289	9.02	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	18
+NX_Q92619	Rho GTPase-activating protein 45	1136	124614	5.76	0	Ruffle membrane;Cytoplasm	NA	Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity.;Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.	NA	NA	Rho GTPase cycle;Neutrophil degranulation	PE1	19
+NX_Q92620	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16	1227	140503	6.11	0	Nucleoplasm;Nucleus	Retinitis pigmentosa 84	Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131).	NA	Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.	Spliceosome;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	16
+NX_Q92621	Nuclear pore complex protein Nup205	2012	227922	5.81	0	Nucleus membrane;Nuclear pore complex	Nephrotic syndrome 13	Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283).	NA	Belongs to the NUP186/NUP192/NUP205 family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	7
+NX_Q92622	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein	972	108622	5.86	0	Early endosome;Late endosome;Lysosome;Cytoplasmic vesicle;Cytosol	Spinocerebellar ataxia, autosomal recessive, 15	Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745).;Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967).	NA	NA	NA	PE1	3
+NX_Q92623	Tetratricopeptide repeat protein 9A	222	24379	9.13	0	NA	NA	NA	NA	Belongs to the TTC9 family.	NA	PE1	14
+NX_Q92624	Amyloid protein-binding protein 2	585	66853	6.44	0	Membrane;Centriolar satellite;Nucleus;Cytoskeleton	NA	May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.	Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.	NA	NA	PE1	17
+NX_Q92625	Ankyrin repeat and SAM domain-containing protein 1A	1134	123108	5.93	0	Nucleoplasm;Cytosol;Cytoplasm;Cell projection	NA	Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity).	Phosphorylated on tyrosine residues in response to EGF and PDGF.	NA	NA	PE1	6
+NX_Q92626	Peroxidasin homolog	1479	165275	6.79	0	Extracellular matrix	Anterior segment dysgenesis 7	Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation.	NA	Belongs to the peroxidase family. XPO subfamily.	Crosslinking of collagen fibrils	PE1	2
+NX_Q92628	Uncharacterized protein KIAA0232	1395	154789	4.71	0	Cytosol	NA	NA	NA	NA	NA	PE1	4
+NX_Q92629	Delta-sarcoglycan	289	32071	9.24	1	Sarcolemma;Cytoskeleton	Muscular dystrophy, limb-girdle, autosomal recessive 6;Cardiomyopathy, dilated 1L	Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.	Disulfide bonds are present.;Glycosylated.	Belongs to the sarcoglycan beta/delta/gamma/zeta family.	Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Viral myocarditis	PE1	5
+NX_Q92630	Dual specificity tyrosine-phosphorylation-regulated kinase 2	601	66652	9.7	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).	Autophosphorylates cotranslationally on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop, but once mature, does not have any protein tyrosine kinase activity. Phosphorylated at Thr-106 and Ser-442 by ATM in response to genotoxic stress.;Under normal conditions, polyubiquitinated in the nucleus by MDM2, leading to its proteasomal degradation. Phosphorylation on Thr-106 and Ser-442 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasomal degradation. Polyubiquitinated by SIAH2, leading to its proteasomal degradation. Polyubiquitinated by SIAH2 occurs under normal conditions, and is enhanced in response to hypoxia.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.	Regulation of TP53 Activity through Phosphorylation	PE1	12
+NX_Q92633	Lysophosphatidic acid receptor 1	364	41109	8.87	7	Cell surface;Endosome;Nucleus speckle;Cell membrane	NA	Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).	N-glycosylated.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Gap junction;G alpha (i) signalling events;G alpha (q) signalling events;Lysosphingolipid and LPA receptors	PE1	9
+NX_Q92636	Protein FAN	917	104372	5.8	0	Nucleolus	NA	Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.	NA	NA	TNFR1-mediated ceramide production	PE1	8
+NX_Q92637	High affinity immunoglobulin gamma Fc receptor IB	280	32232	8.87	1	Cell membrane	NA	May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.	NA	Belongs to the immunoglobulin superfamily. FCGR1 family.	Cross-presentation of soluble exogenous antigens (endosomes);Interferon gamma signaling	PE1	1
+NX_Q92643	GPI-anchor transamidase	395	45252	5.76	1	Endoplasmic reticulum membrane	NA	Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.	The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity.	Belongs to the peptidase C13 family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Attachment of GPI anchor to uPAR	PE1	1
+NX_Q92664	Transcription factor IIIA	365	41515	9.34	0	Nucleoplasm;Nucleus	NA	Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity).	NA	NA	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter	PE1	13
+NX_Q92665	28S ribosomal protein S31, mitochondrial	395	45318	9.32	0	Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mS31 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	13
+NX_Q92667	A-kinase anchor protein 1, mitochondrial	903	97342	4.84	0	Mitochondrion outer membrane;Mitochondrion	NA	Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.	NA	NA	Factors involved in megakaryocyte development and platelet production;Mitochondrial calcium ion transport	PE1	17
+NX_Q92670	Putative zinc finger protein 75C	426	49753	9.07	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE5	11
+NX_Q92673	Sortilin-related receptor	2214	248426	5.32	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;trans-Golgi network membrane;Secreted;Secretory vesicle membrane;Recycling endosome membrane;Golgi apparatus membrane;Early endosome membrane;Multivesicular body membrane	Alzheimer disease	Sorting receptor that directs several proteins to their correct location within the cell (Probable). Along with AP-1 complex, involved Golgi apparatus - endosome sorting (PubMed:17646382). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (PubMed:16174740, PubMed:16407538, PubMed:17855360, PubMed:24523320). May also sort newly produced amyloid-beta peptides to lysosomes for catabolism (PubMed:24523320). Does not affect APP trafficking from the endoplasmic reticulum to Golgi compartments (PubMed:17855360). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor (PubMed:23977241). Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion (PubMed:21994944). Sorting receptor for the GDNF-GFRA1 complex, directing it from the cell surface to endosomes. GDNF is then targeted to lysosomes and degraded, while its receptor GFRA1 recycles back to the cell membrane, resulting in a GDNF clearance pathway. The SORL1-GFRA1 complex further targets RET for endocytosis, but not for degradation, affecting GDNF-induced neurotrophic activities (PubMed:23333276). Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling. In ERBB2-dependent cancer cells, promotes cell proliferation (PubMed:31138794). Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL (PubMed:21385844). Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network (PubMed:18603531). Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue. Does not affect INSR internalization (PubMed:27322061). Plays a role in renal ion homeostasis, controlling the phospho-regulation of SLC12A1/NKCC2 by STK39/SPAK kinase and PPP3CB/calcineurin A beta phosphatase, possibly through intracellular sorting of STK39 and PPP3CB (By similarity). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR. This may promote extracellular matrix proteolysis and hence facilitate cell migration (PubMed:14764453). By acting on the migration of intimal smooth muscle cells, may accelerate intimal thickening following vascular injury (PubMed:14764453). Promotes adhesion of monocytes (PubMed:23486467). Stimulates proliferation and migration of monocytes/macrophages (By similarity). Through its action on intimal smooth muscle cells and macrophages, may accelerate intimal thickening and macrophage foam cell formation in the process of atherosclerosis (By similarity). Regulates hypoxia-enhanced adhesion of hematopoietic stem and progenitor cells to the bone marrow stromal cells via a PLAUR-mediated pathway. This function is mediated by the N-terminal ectodomain (PubMed:23486467). Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet. The N-terminal ectodomain negatively regulates adipose tissue energy expenditure, acting through the inhibition the BMP/Smad pathway (By similarity). May regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation (PubMed:26858303). May regulate IL6 signaling, decreasing cis signaling, possibly by interfering with IL6-binding to membrane-bound IL6R, while up-regulating trans signaling via soluble IL6R (PubMed:28265003).	Within the Golgi apparatus, the propeptide may be cleaved off by FURIN or a furin-like protease (Probable). After cleavage, the propeptide interacts with the mature protein N-terminus, preventing the association with other ligands (PubMed:11294867). At the cell surface, partially subjected to proteolytic shedding that releases the ectodomain in the extracellular milieu (PubMed:11082041, PubMed:16393139, PubMed:16531402, PubMed:28265003). The shedding may be catalyzed by ADAM17/TACE (PubMed:16393139, PubMed:16531402). Following shedding, PSEN1/presenilin-1 cleaves the remaining transmembrane fragment and catalyzes the release of a C-terminal fragment in the cytosol and of a soluble N-terminal beta fragment in the extracellular milieu. The C-terminal cytosolic fragment localizes to the nucleus (PubMed:16531402).;Phosphorylation at Ser-2206 facilitates the interaction with GGA1.;SORL1 is phosphorylated by ROCK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the VPS10-related sortilin family. SORL1 subfamily.	Amyloid fiber formation	PE1	11
+NX_Q92674	Centromere protein I	756	86720	8.98	0	Centromere;Nucleus;Cytosol	NA	Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.	Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation.	Belongs to the CENP-I/CTF3 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	X
+NX_Q92681	Regulatory solute carrier protein family 1 member 1	617	66790	4.78	0	trans-Golgi network;Cell membrane;Cell junction;Nucleoplasm;Nucleus	NA	Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.	NA	NA	Organic cation transport;Intestinal hexose absorption	PE1	1
+NX_Q92685	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase	438	50126	9.56	11	Endoplasmic reticulum membrane	Congenital disorder of glycosylation 1D	Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.	NA	Belongs to the glycosyltransferase 58 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG3 causes ALG3-CDG (CDG-1d)	PE1	3
+NX_Q92686	Neurogranin	78	7618	7.72	0	NA	NA	Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).	Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions.	Belongs to the neurogranin family.	Long-term potentiation	PE1	11
+NX_Q92688	Acidic leucine-rich nuclear phosphoprotein 32 family member B	251	28788	3.94	0	Cytoplasm;Nucleus	NA	Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.	Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).	Belongs to the ANP32 family.	NA	PE1	9
+NX_Q92692	Nectin-2	538	57742	4.74	1	Cell junction;Nucleolus;Cell membrane	NA	Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).;(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).	NA	Belongs to the nectin family.	Cell adhesion molecules (CAMs);Adherens junction;Herpes simplex infection;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Adherens junctions interactions;Nectin/Necl trans heterodimerization	PE1	19
+NX_Q92696	Geranylgeranyl transferase type-2 subunit alpha	567	65072	5.45	0	Nucleoplasm	NA	Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.	NA	Belongs to the protein prenyltransferase subunit alpha family.	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;RAB geranylgeranylation	PE1	14
+NX_Q92698	DNA repair and recombination protein RAD54-like	747	84352	8.85	0	Nucleoplasm;Nucleus	NA	Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells.	NA	Belongs to the SNF2/RAD54 helicase family.	Homologous recombination	PE1	1
+NX_Q92729	Receptor-type tyrosine-protein phosphatase U	1446	162423	6.46	1	Cell junction;Cell membrane	NA	Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.	The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain (By similarity). In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed.;N-glycosylated.;Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated.	Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.	Signaling by SCF-KIT	PE1	1
+NX_Q92730	Rho-related GTP-binding protein Rho6	232	26056	8.24	0	Cytoplasmic vesicle;Cytoskeleton;Cell membrane	NA	Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.	NA	Belongs to the small GTPase superfamily. Rho family.	Axon guidance;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Sema4D mediated inhibition of cell attachment and migration;Sema4D induced cell migration and growth-cone collapse	PE1	12
+NX_Q92731	Estrogen receptor beta	530	59216	8.81	0	Nucleus	Ovarian dysgenesis 8	Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560).	Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.;ESR2 is phosphorylated by MAPK11 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the nuclear hormone receptor family. NR3 subfamily.	PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Nuclear Receptor transcription pathway;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ESR-mediated signaling;Extra-nuclear estrogen signaling	PE1	14
+NX_Q92733	Proline-rich protein PRCC	491	52418	5.02	0	Nucleus speckle;Nucleus	NA	May regulate cell cycle progression through interaction with MAD2L2.	NA	NA	mRNA Splicing - Major Pathway	PE1	1
+NX_Q92734	Protein TFG	400	43448	4.94	0	Endoplasmic reticulum;Cytoplasmic vesicle;Cytosol	Neuropathy, hereditary motor and sensory, Okinawa type;Spastic paraplegia 57, autosomal recessive	Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858).	NA	NA	Pathways in cancer;Thyroid cancer;COPII-mediated vesicle transport	PE1	3
+NX_Q92736	Ryanodine receptor 2	4967	564567	5.73	6	Cell membrane;Membrane;Sarcoplasmic reticulum;Nucleoplasm;Cytosol;Sarcoplasmic reticulum membrane	Arrhythmogenic right ventricular dysplasia, familial, 2;Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.	Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium.;Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels.;RYR2 is phosphorylated by CAMK2A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily.	Calcium signaling pathway;Cardiac muscle contraction;Pancreatic secretion;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Stimuli-sensing channels;Ion homeostasis	PE1	1
+NX_Q92737	Ras-like protein family member 10A	203	22541	9.79	0	Nucleolus;Cell membrane	NA	Potent inhibitor of cellular proliferation.	Isoprenylation is essential for nucleolar localization, and the proliferation-inhibiting activity of RASL10A.	Belongs to the small GTPase superfamily. Ras family.	NA	PE1	22
+NX_Q92738	USP6 N-terminal-like protein	828	94104	9.1	0	Golgi apparatus;Cytoplasmic vesicle	NA	Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.	NA	NA	Retrograde transport at the Trans-Golgi-Network	PE1	10
+NX_Q92743	Serine protease HTRA1	480	51287	8.09	0	Cytosol;Secreted;Cell membrane	Macular degeneration, age-related, 7;Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, 2;Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy	Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.	NA	Belongs to the peptidase S1C family.	Degradation of the extracellular matrix	PE1	10
+NX_Q92747	Actin-related protein 2/3 complex subunit 1A	370	41569	8.46	0	Cell membrane;Cell junction;Cytosol;Nucleus;Cytoskeleton	NA	Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	NA	Belongs to the WD repeat ARPC1 family.	Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;EPHB-mediated forward signaling;Clathrin-mediated endocytosis	PE1	7
+NX_Q92748	Thyroid hormone-inducible hepatic protein	146	16561	4.79	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.	NA	Belongs to the SPOT14 family.	Import of palmitoyl-CoA into the mitochondrial matrix	PE1	11
+NX_Q92750	Transcription initiation factor TFIID subunit 4B	862	91091	9.59	0	Nucleus;Cytoplasm;Nucleoplasm;Nucleolus	Spermatogenic failure 13	Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.	Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).	Belongs to the TAF4 family.	Basal transcription factors;Huntington's disease;Herpes simplex infection;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation	PE1	18
+NX_Q92752	Tenascin-R	1358	149562	4.71	0	Extracellular matrix	NA	Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).	Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity). O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan.	Belongs to the tenascin family.	Focal adhesion;ECM-receptor interaction;ECM proteoglycans	PE1	1
+NX_Q92753	Nuclear receptor ROR-beta	470	53220	7.78	0	Nucleoplasm	Epilepsy, idiopathic generalized 15	Is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity).;Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).	NA	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Circadian rhythm - mammal;Nuclear Receptor transcription pathway	PE1	9
+NX_Q92754	Transcription factor AP-2 gamma	450	49177	7.72	0	Nucleoplasm;Nucleus	NA	Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.	Sumoylated on Lys-10; which inhibits transcriptional activity.	Belongs to the AP-2 family.	SUMOylation of transcription factors;Activation of the TFAP2 (AP-2) family of transcription factors;TFAP2 (AP-2) family regulates transcription of other transcription factors;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;TFAP2 (AP-2) family regulates transcription of cell cycle factors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors	PE1	20
+NX_Q92759	General transcription factor IIH subunit 4	462	52186	9.12	0	Nucleus speckle;Nucleus	NA	Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.	NA	Belongs to the TFB2 family.	Basal transcription factors;Nucleotide excision repair;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;mRNA Capping;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Tat-mediated elongation of the HIV-1 transcript;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;TP53 Regulates Transcription of DNA Repair Genes	PE1	6
+NX_Q92764	Keratin, type I cuticular Ha5	455	50361	4.85	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q92765	Secreted frizzled-related protein 3	325	36254	8.82	0	Secreted	Osteoarthritis 1	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.	NA	Belongs to the secreted frizzled-related protein (sFRP) family.	NA	PE1	2
+NX_Q92766	Ras-responsive element-binding protein 1	1687	181420	6.54	0	Nucleus speckle;Nucleolus	NA	Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_Q92769	Histone deacetylase 2	488	55364	5.59	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.	S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching.	Belongs to the histone deacetylase family. HD type 1 subfamily.	Cell cycle;Notch signaling pathway;Huntington's disease;Pathways in cancer;Chronic myeloid leukemia;Factors involved in megakaryocyte development and platelet production;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;HDACs deacetylate histones;Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;p75NTR negatively regulates cell cycle via SC1;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;SUMOylation of chromatin organization proteins;Regulation of PTEN gene transcription;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	6
+NX_Q92771	Putative ATP-dependent RNA helicase DDX12	950	106006	8.57	0	Nucleus	NA	DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity).	NA	Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.	NA	PE5	12
+NX_Q92772	Cyclin-dependent kinase-like 2	493	56019	8.45	0	Nucleoplasm;Cytoplasm;Centrosome;Nucleus	NA	NA	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	4
+NX_Q92777	Synapsin-2	582	62996	8.58	0	Nucleoplasm;Synapse	Schizophrenia	Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).	Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).	Belongs to the synapsin family.	Serotonin Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle	PE1	3
+NX_Q92781	Retinol dehydrogenase 5	318	34979	9.47	2	Cytoplasmic vesicle;Endoplasmic reticulum membrane	Fundus albipunctatus	Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:11675386, PubMed:10588954, PubMed:9931293, PubMed:9115228). Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (PubMed:9931293, PubMed:29541409).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Cofactor metabolism; retinol metabolism.;Retinol metabolism;The canonical retinoid cycle in rods (twilight vision);RA biosynthesis pathway;Retinoid cycle disease events	PE1	12
+NX_Q92782	Zinc finger protein neuro-d4	380	42502	6.47	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	NA	May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).	NA	Belongs to the requiem/DPF family.	NA	PE1	19
+NX_Q92783	Signal transducing adapter molecule 1	540	59180	4.7	0	Early endosome membrane;Cytoplasm;Cytoplasmic vesicle	NA	Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.	Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.;Ubiquitinated by ITCH.	Belongs to the STAM family.	Endocytosis;Jak-STAT signaling pathway;Endosomal Sorting Complex Required For Transport (ESCRT);EGFR downregulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Metalloprotease DUBs;Negative regulation of MET activity;InlB-mediated entry of Listeria monocytogenes into host cell	PE1	10
+NX_Q92784	Zinc finger protein DPF3	378	43084	6.01	0	Nucleoplasm;Nucleus	NA	Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.	NA	Belongs to the requiem/DPF family.	NA	PE1	14
+NX_Q92785	Zinc finger protein ubi-d4	391	44155	5.94	0	Cytoplasm;Nucleoplasm;Nucleus	Coffin-Siris syndrome 7	Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684).	NA	Belongs to the requiem/DPF family.	NA	PE1	11
+NX_Q92786	Prospero homeobox protein 1	737	83203	6.74	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.	NA	Belongs to the Prospero homeodomain family.	NA	PE1	1
+NX_Q92791	Endoplasmic reticulum protein SC65	437	50381	4.68	0	Endoplasmic reticulum	NA	Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.	NA	Belongs to the leprecan family.	NA	PE1	17
+NX_Q92793	CREB-binding protein	2442	265351	8.83	0	Cytoplasm;Nucleoplasm;Nucleus	Menke-Hennekam syndrome 1;Rubinstein-Taybi syndrome 1	Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493).	Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response (By similarity).;Autoacetylation is required for binding to protein substrates, such as acetylated histones and acetylated TP53/p53.;Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX.;Phosphorylated by CHUK/IKKA at Ser-1382 and Ser-1386; these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B.;CREBBP is phosphorylated by NLK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Cell cycle;Wnt signaling pathway;Notch signaling pathway;TGF-beta signaling pathway;Adherens junction;Jak-STAT signaling pathway;Long-term potentiation;Melanogenesis;Huntington's disease;Tuberculosis;Influenza A;HTLV-I infection;Herpes simplex infection;Pathways in cancer;Renal cell carcinoma;Prostate cancer;HATs acetylate histones;PPARA activates gene expression;Formation of the beta-catenin:TCF transactivating complex;TRAF6 mediated IRF7 activation;Pre-NOTCH Transcription and Translation;Notch-HLH transcription pathway;Regulation of gene expression by Hypoxia-inducible Factor;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Attenuation phase;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;TRAF3-dependent IRF activation pathway;CD209 (DC-SIGN) signaling;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activation of the TFAP2 (AP-2) family of transcription factors;RUNX3 regulates NOTCH signaling;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;NOTCH3 Intracellular Domain Regulates Transcription;Estrogen-dependent gene expression;SUMOylation of transcription cofactors;NOTCH4 Intracellular Domain Regulates Transcription;FOXO-mediated transcription of cell death genes;Regulation of FOXO transcriptional activity by acetylation	PE1	16
+NX_Q92794	Histone acetyltransferase KAT6A	2004	225028	5.5	0	Nucleus speckle;Nucleolus;Nucleoplasm;PML body;Cytosol;Nucleus	Mental retardation, autosomal dominant 32	Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.	Phosphorylation at Thr-369 by PKB/AKT1 inhibits its interaction with PML and negatively regulates its acetylation activity towards p53/TP53.;Autoacetylation at Lys-604 is required for proper function (By similarity). Autoacetylated.	Belongs to the MYST (SAS/MOZ) family.	HATs acetylate histones;Regulation of TP53 Activity through Acetylation	PE1	8
+NX_Q92796	Disks large homolog 3	817	90314	6.56	0	Nucleoplasm;Nucleolus	Mental retardation, X-linked 90	Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.	NA	Belongs to the MAGUK family.	RAF/MAP kinase cascade;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;NrCAM interactions;Activation of Ca-permeable Kainate Receptor;Synaptic adhesion-like molecules;Neurexins and neuroligins;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	X
+NX_Q92797	Symplekin	1274	141148	5.82	0	Cell membrane;Cell junction;Nucleoplasm;Tight junction;Cytosol;Cytoskeleton	NA	Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.	NA	Belongs to the Symplekin family.	mRNA surveillance pathway;Tight junction;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	19
+NX_Q92800	Histone-lysine N-methyltransferase EZH1	747	85271	8.01	0	Nucleoplasm;Nucleus	NA	Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.	NA	PE1	17
+NX_Q92802	NEDD4-binding protein 2-like 2	583	67459	5.96	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	13
+NX_Q92804	TATA-binding protein-associated factor 2N	592	61830	8.04	0	Nucleoplasm;Cytoplasm;Nucleus	NA	RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).	Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity.;ADP-ribosylated during genotoxic stress.	Belongs to the RRM TET family.	Basal transcription factors;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation	PE1	17
+NX_Q92805	Golgin subfamily A member 1	767	88184	5.24	0	Golgi apparatus;trans-Golgi network membrane;Acrosome;Golgi apparatus membrane	NA	Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking.	NA	NA	Retrograde transport at the Trans-Golgi-Network	PE1	9
+NX_Q92806	G protein-activated inward rectifier potassium channel 3	393	44020	4.86	2	Membrane	NA	This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).	NA	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ9 subfamily.	Dopaminergic synapse;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	PE1	1
+NX_Q92813	Type II iodothyronine deiodinase	273	30552	8.18	1	Membrane;Nucleoplasm;Cytosol	NA	Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	Ubiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33.	Belongs to the iodothyronine deiodinase family.	Regulation of thyroid hormone activity	PE1	14
+NX_Q92817	Envoplakin	2033	231604	6.56	0	Cytosol;Desmosome;Cornified envelope;Cytoskeleton	NA	Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.	NA	Belongs to the plakin or cytolinker family.	Formation of the cornified envelope	PE1	17
+NX_Q92819	Hyaluronan synthase 2	552	63566	8.85	7	Membrane;Nucleus speckle	NA	Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).	NA	Belongs to the NodC/HAS family.	Glycan biosynthesis; hyaluronan biosynthesis.;Hyaluronan biosynthesis and export	PE1	8
+NX_Q92820	Gamma-glutamyl hydrolase	318	35964	6.66	0	Lysosome;Melanosome;Extracellular space	NA	Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.	NA	Belongs to the peptidase C26 family.	Folate biosynthesis;Neutrophil degranulation	PE1	8
+NX_Q92823	Neuronal cell adhesion molecule	1304	143890	5.45	1	Cell membrane;Secreted;Nucleoplasm;Cytoplasmic vesicle;Axon	NA	Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.	NA	Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.	Cell adhesion molecules (CAMs);Interaction between L1 and Ankyrins;NrCAM interactions;Neurofascin interactions	PE1	7
+NX_Q92824	Proprotein convertase subtilisin/kexin type 5	1860	206942	5.71	1	Golgi apparatus;Endomembrane system;Secreted	NA	Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.	NA	Belongs to the peptidase S8 family.	NGF processing;Assembly of active LPL and LIPC lipase complexes	PE1	9
+NX_Q92826	Homeobox protein Hox-B13	284	30676	9.15	0	Nucleoplasm;Nucleus	Prostate cancer	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536).	NA	Belongs to the Abd-B homeobox family.	NA	PE1	17
+NX_Q92828	Coronin-2A	525	59763	8.24	0	Cytosol;Cell membrane	NA	NA	NA	Belongs to the WD repeat coronin family.	NA	PE1	9
+NX_Q92830	Histone acetyltransferase KAT2A	837	93926	9.18	0	Centrosome;Nucleus;Chromosome	NA	(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.;Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at Lys-9 (H3K9ac), leading to promote IL2 expression (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:29174768, PubMed:27796307). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).	NA	Belongs to the acetyltransferase family. GCN5 subfamily.	Notch signaling pathway;HTLV-I infection;HATs acetylate histones;RNA Polymerase I Transcription Initiation;Pre-NOTCH Transcription and Translation;Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;B-WICH complex positively regulates rRNA expression;Ub-specific processing proteases;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE1	17
+NX_Q92831	Histone acetyltransferase KAT2B	832	93013	9.16	0	Nucleoplasm;Centrosome;Nucleus	NA	Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Also acetylates spermidine (PubMed:27389534).;(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.	NA	Belongs to the acetyltransferase family. GCN5 subfamily.	Notch signaling pathway;HTLV-I infection;HATs acetylate histones;YAP1- and WWTR1 (TAZ)-stimulated gene expression;RNA Polymerase I Transcription Initiation;Pre-NOTCH Transcription and Translation;Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;Physiological factors;B-WICH complex positively regulates rRNA expression;Metalloprotease DUBs;RUNX3 regulates NOTCH signaling;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;NOTCH3 Intracellular Domain Regulates Transcription;Estrogen-dependent gene expression;NOTCH4 Intracellular Domain Regulates Transcription;Regulation of FOXO transcriptional activity by acetylation	PE1	3
+NX_Q92832	Protein kinase C-binding protein NELL1	810	89635	5.66	0	Cytoplasm;Nucleus envelope;Secreted	NA	Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.	NA	NA	NA	PE1	11
+NX_Q92833	Protein Jumonji	1246	138734	9.46	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.	NA	NA	PRC2 methylates histones and DNA	PE1	6
+NX_Q92834	X-linked retinitis pigmentosa GTPase regulator	1020	113387	4.79	0	Golgi apparatus;Flagellum axoneme;Cilium;Cilium basal body;Centrosome;Cilium axoneme	Cone-rod dystrophy, X-linked 1;Macular degeneration, X-linked, atrophic;Retinitis pigmentosa 3;Retinitis pigmentosa and sinorespiratory infections with or without deafness	Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia.	Prenylated.	NA	NA	PE1	X
+NX_Q92835	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	1189	133292	7.38	0	Cytoplasm;Cell membrane;Membrane;Cytosol;Membrane raft;Cytoskeleton	NA	Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8723348, PubMed:10764818, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:9108392, PubMed:10764818, PubMed:8769125). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression.	Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding.;INPP5D is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.	Phosphatidylinositol signaling system;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Insulin signaling pathway;Synthesis of PIPs at the plasma membrane;Downstream TCR signaling;Interleukin receptor SHC signaling;Synthesis of IP3 and IP4 in the cytosol;PECAM1 interactions	PE1	2
+NX_Q92837	Proto-oncogene FRAT1	279	29093	7.65	0	Cytoplasm;Cytosol;Cytoplasmic vesicle	NA	Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.	Phosphorylated.	Belongs to the GSK-3-binding protein family.	Wnt signaling pathway;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Beta-catenin phosphorylation cascade	PE1	10
+NX_Q92838	Ectodysplasin-A	391	41294	8.54	1	Cytoplasmic vesicle;Secreted;Lipid droplet;Cell membrane	Tooth agenesis, selective, X-linked, 1;Ectodermal dysplasia 1, hypohidrotic, X-linked	Binds only to the receptor EDA2R.;Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R (PubMed:8696334, PubMed:11039935, PubMed:27144394). May also play a role in cell adhesion (By similarity).;Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R.	N-glycosylated.;Processing by furin produces a secreted form.	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	X
+NX_Q92839	Hyaluronan synthase 1	578	64832	9.35	7	Membrane;Nucleoplasm;Cell membrane	NA	Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).	NA	Belongs to the NodC/HAS family.	Glycan biosynthesis; hyaluronan biosynthesis.;Hyaluronan biosynthesis and export	PE1	19
+NX_Q92841	Probable ATP-dependent RNA helicase DDX17	729	80272	8.53	0	Nucleus;Cytosol;Nucleus speckle;Nucleolus	NA	As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637).	Sumoylation significantly increases stability. It also promotes interaction specifically with HDAC1 (but not HDAC2, nor HDAC3) and strongly stimulates ESR1 and TP53 coactivation.;Acetylation at lysine residues stabilizes the protein, stimulates interaction with HDAC1 and HDAC3, but not HDAC2, and represses ESR1 and TP53 coactivation activity.	Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.	SUMOylation of transcription cofactors	PE1	22
+NX_Q92843	Bcl-2-like protein 2	193	20746	5.21	0	Mitochondrion membrane;Nucleoplasm	NA	Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.	NA	Belongs to the Bcl-2 family.	NA	PE1	14
+NX_Q92844	TRAF family member-associated NF-kappa-B activator	425	47816	5.46	0	Cytoplasm;Cytosol;Nucleolus	NA	Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.	Phosphorylated by IKBKE.;(Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C (PubMed:26363073). This cleavage allows the virus to disrupt the TANK-TBK1-IKKepsilon-IRF3 complex, thereby inhibiting the induction of the IFN-beta signal pathway (PubMed:28487378).;(Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways.	NA	RIG-I-like receptor signaling pathway;TRAF6 mediated IRF7 activation;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;TICAM1-dependent activation of IRF3/IRF7	PE1	2
+NX_Q92845	Kinesin-associated protein 3	792	91205	4.96	0	NA	NA	Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity).	Phosphorylated on tyrosine residues by SRC in vitro; this reduces the binding affinity of the protein for RAP1GDS1.;KIFAP3 is phosphorylated by PTK6 (Phosphotyrosine:PTM-0255)	NA	MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	1
+NX_Q92847	Growth hormone secretagogue receptor type 1	366	41329	8.65	7	Cell membrane	Growth hormone deficiency, isolated partial	Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	3
+NX_Q92851	Caspase-10	521	58951	6.95	0	Golgi apparatus;Cytoplasmic vesicle	Autoimmune lymphoproliferative syndrome 2A;Familial non-Hodgkin lymphoma;Gastric cancer	Is proteolytically inactive.;Can enhance NF-kappaB activity but promotes only slight apoptosis.;Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.	Cleavage by granzyme B and autocatalytic activity generate the two active subunits.	Belongs to the peptidase C14A family.	Apoptosis;RIG-I-like receptor signaling pathway;Tuberculosis;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;TRAIL signaling;FasL/ CD95L signaling;TP53 Regulates Transcription of Caspase Activators and Caspases	PE1	2
+NX_Q92854	Semaphorin-4D	862	96150	8.25	1	Cytoplasmic vesicle;Endoplasmic reticulum;Cell membrane	NA	Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).	NA	Belongs to the semaphorin family.	Axon guidance;Sema4D mediated inhibition of cell attachment and migration;Other semaphorin interactions;Sema4D induced cell migration and growth-cone collapse	PE1	9
+NX_Q92858	Protein atonal homolog 1	354	38160	8.26	0	Nucleus	NA	Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).	NA	NA	NA	PE2	4
+NX_Q92859	Neogenin	1461	160017	6.08	1	Golgi apparatus;Nucleoplasm;Cell membrane	NA	Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.	NA	Belongs to the immunoglobulin superfamily. DCC family.	Cell adhesion molecules (CAMs);Netrin-1 signaling;Myogenesis	PE1	15
+NX_Q92870	Amyloid-beta A4 precursor protein-binding family B member 2	758	83374	5.74	0	Mitochondrion	NA	May modulate the internalization of amyloid-beta precursor protein.	NA	NA	NA	PE1	4
+NX_Q92871	Phosphomannomutase 1	262	29747	5.53	0	Cytoplasm;Cytosol	NA	Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.	NA	Belongs to the eukaryotic PMM family.	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.;Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Synthesis of GDP-mannose	PE1	22
+NX_Q92874	Deoxyribonuclease-1-like 2	299	32853	4.8	0	Endoplasmic reticulum;Cytoplasm;Mitochondrion;Secreted	NA	Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.	NA	Belongs to the DNase I family.	NA	PE1	16
+NX_Q92876	Kallikrein-6	244	26856	7.15	0	Cytoplasm;Mitochondrion;Microsome;Secreted;Nucleus membrane;Nucleolus;Nucleoplasm;Cytoskeleton	NA	Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.	Inactivated by autolytic cleavage after Arg-80.	Belongs to the peptidase S1 family. Kallikrein subfamily.	NA	PE1	19
+NX_Q92878	DNA repair protein RAD50	1312	153892	6.47	0	Nucleoplasm;Telomere;Nucleus;Chromosome	Nijmegen breakage syndrome-like disorder	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).	NA	Belongs to the SMC family. RAD50 subfamily.	Homologous recombination;Non-homologous end-joining;DNA Damage/Telomere Stress Induced Senescence;Meiotic recombination;G2/M DNA damage checkpoint;Sensing of DNA Double Strand Breaks;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Single Strand Annealing (SSA);HDR through MMEJ (alt-NHEJ);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Nonhomologous End-Joining (NHEJ);Regulation of TP53 Activity through Phosphorylation	PE1	5
+NX_Q92879	CUGBP Elav-like family member 1	486	52063	8.7	0	Cytoplasm;Nucleoplasm;Nucleus	NA	RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233).	Phosphorylated. Its phosphorylation status increases in senescent cells.	Belongs to the CELF/BRUNOL family.	NA	PE1	11
+NX_Q92882	Osteoclast-stimulating factor 1	214	23787	5.46	0	Cytoplasm;Cytosol	NA	Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.	NA	NA	Neutrophil degranulation	PE1	9
+NX_Q92886	Neurogenin-1	237	25718	6.9	0	Nucleus	NA	Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).	NA	NA	NA	PE1	5
+NX_Q92887	Canalicular multispecific organic anion transporter 1	1545	174207	8.57	17	Apical cell membrane	Dubin-Johnson syndrome	Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Also transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). May function as a cellular cisplatin transporter.	NA	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.	ABC transporters;Bile secretion;ABC-family proteins mediated transport;Defective ABCC2 causes Dubin-Johnson syndrome	PE1	10
+NX_Q92888	Rho guanine nucleotide exchange factor 1	912	102435	5.47	0	Membrane;Cytoplasm;Cytosol;Cell membrane	NA	Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.	Phosphorylated by PKCA. Angiotensin-2 induced Tyr-738 phosphorylation is mediated by JAK2.	NA	Vascular smooth muscle contraction;Regulation of actin cytoskeleton;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	19
+NX_Q92889	DNA repair endonuclease XPF	916	104486	6.5	0	Nucleoplasm;Cell junction;Nucleus	Xeroderma pigmentosum complementation group F;Fanconi anemia complementation group Q;Xeroderma pigmentosum type F/Cockayne syndrome;XFE progeroid syndrome	Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.	NA	Belongs to the XPF family.	Dual incision in TC-NER;HDR through Single Strand Annealing (SSA);Dual Incision in GG-NER;Formation of Incision Complex in GG-NER;Fanconi Anemia Pathway	PE1	16
+NX_Q92890	Ubiquitin recognition factor in ER-associated degradation protein 1	307	34500	6.27	0	Nucleus;Nucleoplasm;Cytosol;Nucleolus	NA	Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).	NA	Belongs to the UFD1 family.	Protein degradation; proteasomal ubiquitin-dependent pathway.;Protein processing in endoplasmic reticulum;Translesion Synthesis by POLH;Ub-specific processing proteases	PE1	22
+NX_Q92896	Golgi apparatus protein 1	1179	134552	6.52	1	Golgi apparatus;Golgi apparatus membrane	NA	Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).	N-glycosylated. Contains sialic acid residues (By similarity).;Fucosylation is essential for binding to E-selectin.	NA	Cell adhesion molecules (CAMs);Cell surface interactions at the vascular wall	PE1	16
+NX_Q92900	Regulator of nonsense transcripts 1	1129	124345	6.18	0	Cytoplasm;Nucleoplasm;P-body;Nucleus	NA	RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability.	Phosphorylated by SMG1; required for formation of mRNA surveillance complexes.;UPF1 is phosphorylated by ATR	Belongs to the DNA2/NAM7 helicase family.	RNA transport;mRNA surveillance pathway;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PE1	19
+NX_Q92901	60S ribosomal protein L3-like	407	46296	10.45	0	Nucleus speckle	NA	NA	NA	Belongs to the universal ribosomal protein uL3 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	16
+NX_Q92902	Hermansky-Pudlak syndrome 1 protein	700	79292	5.62	0	NA	Hermansky-Pudlak syndrome 1	Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991).	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	10
+NX_Q92903	Phosphatidate cytidylyltransferase 1	461	53304	8.29	6	Nucleoplasm;Endoplasmic reticulum membrane;Nucleus membrane	NA	Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.	NA	Belongs to the CDS family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PI	PE1	4
+NX_Q92904	Deleted in azoospermia-like	295	33178	8.92	0	Cytoplasm;Nucleus	NA	RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).	NA	Belongs to the RRM DAZ family.	NA	PE1	3
+NX_Q92905	COP9 signalosome complex subunit 5	334	37579	6.1	0	Nucleoplasm;Cytosol;Perinuclear region;Synaptic vesicle;Nucleus	NA	Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.	NA	Belongs to the peptidase M67A family. CSN5 subfamily.	Formation of TC-NER Pre-Incision Complex;DNA Damage Recognition in GG-NER;Cargo recognition for clathrin-mediated endocytosis;Neddylation	PE1	8
+NX_Q92908	Transcription factor GATA-6	595	60033	8.68	0	Nucleoplasm;Nucleus	Conotruncal heart malformations;Atrial septal defect 9;Tetralogy of Fallot;Pancreatic agenesis and congenital heart defects;Atrioventricular septal defect 5	Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity).	NA	NA	Factors involved in megakaryocyte development and platelet production;Surfactant metabolism	PE1	18
+NX_Q92911	Sodium/iodide cotransporter	643	68666	7.37	13	Membrane	Thyroid dyshormonogenesis 1	Mediates iodide uptake in the thyroid gland.	NA	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Organic anion transporters;Thyroxine biosynthesis;Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)	PE1	19
+NX_Q92913	Fibroblast growth factor 13	245	27564	9.92	0	Cytoplasm;Growth cone;Nucleolus;Filopodium;Cytosol;Dendrite;Nucleus	NA	Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus.;May also play a role in MAPK signaling.;May regulate voltage-gated sodium channels transport and function.	May be phosphorylated.	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;Phase 0 - rapid depolarisation	PE1	X
+NX_Q92914	Fibroblast growth factor 11	225	25005	9.92	0	Centrosome	NA	Probably involved in nervous system development and function.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;Phase 0 - rapid depolarisation	PE2	17
+NX_Q92915	Fibroblast growth factor 14	247	27702	10.11	0	Nucleolus;Nucleus	Spinocerebellar ataxia 27	Probably involved in nervous system development and function.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;Phase 0 - rapid depolarisation	PE1	13
+NX_Q92917	G-patch domain and KOW motifs-containing protein	476	52229	5.85	0	Nucleoplasm;Nucleus	NA	RNA-binding protein involved in pre-mRNA splicing.	Phosphorylation regulates its ability to bind RNA.	Belongs to the MOS2 family.	mRNA Splicing - Major Pathway	PE1	X
+NX_Q92918	Mitogen-activated protein kinase kinase kinase kinase 1	833	91296	8.65	0	Nucleoplasm;Cell membrane	NA	Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.	Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome.;Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	MAPK signaling pathway	PE1	19
+NX_Q92922	SWI/SNF complex subunit SMARCC1	1105	122867	5.51	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).	Phosphorylated on undefined residues at the G2/M transition by ERK1 and other kinases. This may contribute to cell cycle specific inactivation of remodeling complexes containing the phosphorylated protein.	Belongs to the SMARCC family.	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	3
+NX_Q92925	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2	531	58921	9.66	0	Nucleoplasm;Nucleus	Specific granule deficiency 2	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (PubMed:28369036).	Ubiquitinated through a signaling process involving RAC1 and the RING finger protein UNKL.	Belongs to the SMARCD family.	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	17
+NX_Q92928	Putative Ras-related protein Rab-1C	201	22017	5.25	0	Membrane;Cytoplasm	NA	Protein transport. Probably involved in vesicular traffic (By similarity).	Phosphocholinated at Ser-76 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB.	Belongs to the small GTPase superfamily. Rab family.	NA	PE5	9
+NX_Q92930	Ras-related protein Rab-8B	207	23584	9.15	0	Cell membrane;Phagosome membrane;Nucleoplasm;Phagosome;Cytoplasmic vesicle	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).	Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.	Belongs to the small GTPase superfamily. Rab family.	RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs;RAB geranylgeranylation	PE1	15
+NX_Q92932	Receptor-type tyrosine-protein phosphatase N2	1015	111271	5.55	1	Cytoplasmic vesicle;Synaptic vesicle membrane;Secretory vesicle membrane	NA	Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550).	Subject to proteolytic cleavage at multiple sites.	Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.	Type I diabetes mellitus;Neutrophil degranulation	PE1	7
+NX_Q92934	Bcl2-associated agonist of cell death	168	18392	6.6	0	Mitochondrion outer membrane;Cytoplasm;Mitochondrion	NA	Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.	Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99.;Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis.;BAD is phosphorylated by SGK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the Bcl-2 family.	ErbB signaling pathway;Apoptosis;VEGF signaling pathway;Focal adhesion;Neurotrophin signaling pathway;Insulin signaling pathway;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Toxoplasmosis;Tuberculosis;Hepatitis C;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Endometrial cancer;Prostate cancer;Melanoma;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;NRAGE signals death through JNK;Activation of BAD and translocation to mitochondria;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Constitutive Signaling by AKT1 E17K in Cancer;AKT phosphorylates targets in the cytosol	PE1	11
+NX_Q92935	Exostosin-like 1	676	74697	8.51	1	Endoplasmic reticulum membrane	NA	Probable glycosyltransferase.	NA	Belongs to the glycosyltransferase 47 family.	Protein modification; protein glycosylation.;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;XBP1(S) activates chaperone genes	PE1	1
+NX_Q92945	Far upstream element-binding protein 2	711	73115	6.85	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.	Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function.	Belongs to the KHSRP family.	ATF4 activates genes in response to endoplasmic reticulum stress;KSRP (KHSRP) binds and destabilizes mRNA	PE1	19
+NX_Q92947	Glutaryl-CoA dehydrogenase, mitochondrial	438	48127	8.31	0	Mitochondrion matrix;Mitochondrion	Glutaric aciduria 1	Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor.;Is inactive.	NA	Belongs to the acyl-CoA dehydrogenase family.	Amino-acid metabolism; lysine degradation.;Amino-acid metabolism; tryptophan metabolism.;Fatty acid metabolism;Lysine degradation;Tryptophan metabolism;Metabolic pathways;Lysine catabolism	PE1	19
+NX_Q92949	Forkhead box protein J1	421	45247	5.04	0	Nucleus	Allergic rhinitis	Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung.	NA	Belongs to the FOXJ1 family.	NA	PE1	17
+NX_Q92952	Small conductance calcium-activated potassium channel protein 1	543	59987	9.04	6	Membrane;Cytosol;Cytoskeleton	NA	Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).	NA	Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.	Ca2+ activated K+ channels	PE2	19
+NX_Q92953	Potassium voltage-gated channel subfamily B member 2	911	102563	5.81	6	Cell membrane;Perikaryon;Nucleolus;Dendrite;Midbody	NA	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.	Phosphorylated.	Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.	Voltage gated Potassium channels	PE1	8
+NX_Q92954	Proteoglycan 4	1404	151061	9.54	0	Secreted	Camptodactyly-arthropathy-coxa vara-pericarditis syndrome	Plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.;Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.	O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans (PubMed:25187573).;The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage.;N-glycosylated (PubMed:16335952).	NA	NA	PE1	1
+NX_Q92956	Tumor necrosis factor receptor superfamily member 14	283	30392	6.93	1	Cytoplasm;Cytosol;Cell membrane	NA	(Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.;(Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.;Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044) (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044) (By similarity).	N-glycosylated.	Belongs to the tumor necrosis factor receptor superfamily.	Cytokine-cytokine receptor interaction;Herpes simplex infection;TNFs bind their physiological receptors;Costimulation by the CD28 family	PE1	1
+NX_Q92959	Solute carrier organic anion transporter family member 2A1	643	70044	9.13	12	Cell membrane	Hypertrophic osteoarthropathy, primary, autosomal recessive, 2	May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.	NA	Belongs to the organo anion transporter (TC 2.A.60) family.	Transport of organic anions;Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)	PE1	3
+NX_Q92963	GTP-binding protein Rit1	219	25145	9.2	0	Cell membrane	Noonan syndrome 8	Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.	NA	Belongs to the small GTPase superfamily. Ras family.	Signalling to p38 via RIT and RIN	PE1	1
+NX_Q92966	snRNA-activating protein complex subunit 3	411	46753	5.12	0	Nucleoplasm;Nucleus;Nucleolus	NA	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.	NA	Belongs to the SNAPC3/SRD2 family.	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA polymerase II transcribes snRNA genes	PE1	9
+NX_Q92968	Peroxisomal membrane protein PEX13	403	44130	7.77	1	Peroxisome membrane;Cytoplasmic vesicle	Peroxisome biogenesis disorder 11A;Peroxisome biogenesis disorder 11B;Peroxisome biogenesis disorder complementation group 13	Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins.	NA	Belongs to the peroxin-13 family.	Peroxisome;E3 ubiquitin ligases ubiquitinate target proteins;Peroxisomal protein import;Class I peroxisomal membrane protein import	PE1	2
+NX_Q92973	Transportin-1	898	102355	4.83	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	(Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.;Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19 (By similarity). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571).	NA	Belongs to the importin beta family. Importin beta-2 subfamily.	Intraflagellar transport;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	PE1	5
+NX_Q92974	Rho guanine nucleotide exchange factor 2	986	111543	6.89	0	Cytoplasm;Golgi apparatus;Tight junction;Ruffle membrane;Cytoplasmic vesicle;Spindle;Cytoskeleton	Neurodevelopmental disorder with midbrain and hindbrain malformations	Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity).	Phosphorylation of Ser-886 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner.;ARHGEF2 is phosphorylated by MAPK3	NA	Pathogenic Escherichia coli infection;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	1
+NX_Q92979	Ribosomal RNA small subunit methyltransferase NEP1	244	26720	9.28	0	Nucleoplasm;Nucleolus	Bowen-Conradi syndrome	S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity).	NA	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	12
+NX_Q92982	Ninjurin-1	152	16345	5.83	2	Membrane	NA	Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.	NA	Belongs to the ninjurin family.	NA	PE1	9
+NX_Q92985	Interferon regulatory factor 7	503	54278	5.89	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Immunodeficiency 39	Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.	Sumoylated by TRIM28, which inhibits its transactivation activity.;Acetylation inhibits its DNA-binding ability and activity.;In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway, phosphorylated by IRAK1.;TRAF6-mediated ubiquitination is required for IRF7 activation.;IRF7 is phosphorylated by IKBKE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);IRF7 is phosphorylated by IRAK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the IRF family.	Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Hepatitis C;Measles;Influenza A;Herpes simplex infection;Interferon gamma signaling;Interferon alpha/beta signaling;DEx/H-box helicases activate type I IFN and inflammatory cytokines production;TRAF6 mediated IRF7 activation;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;TRAF3-dependent IRF activation pathway;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;TICAM1-dependent activation of IRF3/IRF7	PE1	11
+NX_Q92988	Homeobox protein DLX-4	240	26263	9.25	0	Nucleoplasm;Nucleus	Non-syndromic orofacial cleft 15	May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.	NA	Belongs to the distal-less homeobox family.	NA	PE1	17
+NX_Q92989	Polyribonucleotide 5'-hydroxyl-kinase Clp1	425	47646	6.2	0	Nucleoplasm;Nucleus	Pontocerebellar hypoplasia 10	Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. DsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.	NA	Belongs to the Clp1 family. Clp1 subfamily.	mRNA surveillance pathway;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;tRNA processing in the nucleus;RNA Polymerase II Transcription Termination	PE1	11
+NX_Q92990	Glomulin	594	68208	5.24	0	Nucleoplasm;Cytosol	Glomuvenous malformations	Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281).	Phosphorylated on tyrosine residues.	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	1
+NX_Q92993	Histone acetyltransferase KAT5	513	58582	8.75	0	Nucleoplasm;Nucleus;Perinuclear region;Nucleolus	NA	Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:16387653, PubMed:19909775, PubMed:15196461). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:14966270, PubMed:15196461). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:15196461). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:15196461). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17360565, PubMed:17996965, PubMed:29040603, PubMed:30704899). Directly acetylates and activates ATM (PubMed:16141325). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565). Acetylates RAN at 'Lys-134' (PubMed:29040603). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899).	(Microbial infection) In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.;Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies.;Ubiquitinated by MDM2, leading to its proteasome-dependent degradation.;Autoacetylation at Lys-327 is required for proper function.;Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase (PubMed:12468530). The phosphorylated form has a higher histone acetyltransferase activity (PubMed:12468530). Phosphorylation at Ser-86 by GSK3 (GSK3A or GSK3B) activates acetyltransferase activity (PubMed:30704899). Phosphorylation at Ser-90 is a prerequisite for phosphorylation at Ser-86 by GSK3 (PubMed:30704899).	Belongs to the MYST (SAS/MOZ) family.	HTLV-I infection;HATs acetylate histones;Formation of the beta-catenin:TCF transactivating complex;DNA Damage/Telomere Stress Induced Senescence;G2/M DNA damage checkpoint;Sensing of DNA Double Strand Breaks;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Nonhomologous End-Joining (NHEJ);Regulation of TP53 Activity through Phosphorylation;Estrogen-dependent gene expression	PE1	11
+NX_Q92994	Transcription factor IIIB 90 kDa subunit	677	73840	5.29	0	Nucleoplasm;Nucleus	Cerebellofaciodental syndrome	General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA.;Is required for transcription of the U6 promoter.	NA	Belongs to the TFIIB family.	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter	PE1	14
+NX_Q92995	Ubiquitin carboxyl-terminal hydrolase 13	863	97327	5.33	0	Nucleoplasm;Cytosol	NA	Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.	NA	Belongs to the peptidase C19 family.	Ub-specific processing proteases;Regulation of PTEN stability and activity	PE1	3
+NX_Q92997	Segment polarity protein dishevelled homolog DVL-3	716	78055	6.18	0	Cytoplasm;Centrosome;Cytoskeleton;Midbody ring	Robinow syndrome, autosomal dominant 3	Involved in the signal transduction pathway mediated by multiple Wnt genes.	Arginine methylation may function as a switch in regulation of function in Wnt signaling.;Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.;Phosphorylated by CSNK1D.	Belongs to the DSH family.	Wnt signaling pathway;Notch signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Degradation of DVL;RHO GTPases Activate Formins;TCF dependent signaling in response to WNT;PCP/CE pathway;Disassembly of the destruction complex and recruitment of AXIN to the membrane;WNT mediated activation of DVL;Negative regulation of TCF-dependent signaling by DVL-interacting proteins	PE1	3
+NX_Q93008	Probable ubiquitin carboxyl-terminal hydrolase FAF-X	2570	292280	5.52	0	Cytoplasm;Growth cone;Cytoplasmic vesicle	Mental retardation, X-linked 99	Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed:16322459, PubMed:18254724, PubMed:19135894, PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed:29626158).	NA	Belongs to the peptidase C19 family.	Downregulation of SMAD2/3:SMAD4 transcriptional activity;Amyloid fiber formation;Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Peroxisomal protein import	PE1	X
+NX_Q93009	Ubiquitin carboxyl-terminal hydrolase 7	1102	128302	5.33	0	Cytoplasm;PML body;Nucleus;Chromosome	NA	(Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.;Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:26678539). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371).	Not sumoylated.;Polyubiquitinated by herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110; leading to its subsequent proteasomal degradation.;Ubiquitinated at Lys-869.;Is phosphorylated at positions Ser-18 and Ser-963.;Phosphorylated.;Polyneddylated.	Belongs to the peptidase C19 family.	Herpes simplex infection;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Regulation of TP53 Degradation;Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Regulation of PTEN localization	PE1	16
+NX_Q93015	N-alpha-acetyltransferase 80	286	31445	7.75	0	Cytosol	NA	N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:30028079, PubMed:29581253). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:30028079, PubMed:29581253). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992).	NA	Belongs to the acetyltransferase family.	NA	PE1	3
+NX_Q93033	Immunoglobulin superfamily member 2	1021	115109	6.51	1	Membrane;Mitochondrion	NA	Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.	N-glycosylated.	NA	Generation of second messenger molecules	PE1	1
+NX_Q93034	Cullin-5	780	90955	8.08	0	Golgi apparatus;Cytosol	NA	Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.	Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN).	Belongs to the cullin family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Vif-mediated degradation of APOBEC3G;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downregulation of ERBB2 signaling;Neddylation	PE1	11
+NX_Q93038	Tumor necrosis factor receptor superfamily member 25	417	45385	6.01	1	Cell membrane;Focal adhesion;Secreted;Nucleoplasm;Cytoskeleton	NA	Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.	Glycosylated.	NA	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	1
+NX_Q93045	Stathmin-2	179	20828	8.4	0	Cytoplasm;Golgi apparatus;Growth cone;Membrane;Endoplasmic reticulum;Lamellipodium;Endosome;Cytoplasmic vesicle;Axon;Perinuclear region	NA	Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).	Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.;Sumoylated.;N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.	Belongs to the stathmin family.	NA	PE1	8
+NX_Q93050	V-type proton ATPase 116 kDa subunit a isoform 1	837	96413	6.02	8	Golgi apparatus;Nucleus speckle;Cell membrane;Cytoplasmic vesicle membrane;Melanosome;Cytoplasmic vesicle;Cytosol	NA	Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).	NA	Belongs to the V-ATPase 116 kDa subunit family.	Oxidative phosphorylation;Metabolic pathways;Lysosome;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Tuberculosis;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport;Neutrophil degranulation	PE1	17
+NX_Q93052	Lipoma-preferred partner	612	65746	7.18	0	Cytoplasm;Cell membrane;Cell junction;Focal adhesion;Cytosol;Nucleus	NA	May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.	NA	Belongs to the zyxin/ajuba family.	NA	PE1	3
+NX_Q93062	RNA-binding protein with multiple splicing	196	21802	7.77	0	Cytoplasm;Nucleoplasm;P-body;Cytosol;Nucleus	NA	Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403).	NA	NA	NA	PE1	8
+NX_Q93063	Exostosin-2	718	82255	6.12	1	Golgi apparatus;Endoplasmic reticulum membrane;Golgi apparatus membrane	Hereditary multiple exostoses 2;Potocki-Shaffer syndrome;Seizures, scoliosis, and macrocephaly syndrome	Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).	NA	Belongs to the glycosyltransferase 47 family.	Protein modification; protein glycosylation.;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;HS-GAG biosynthesis;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS	PE1	11
+NX_Q93070	Ecto-ADP-ribosyltransferase 4	314	35878	9.31	0	Cytoplasm;Cell membrane	NA	NA	NA	Belongs to the Arg-specific ADP-ribosyltransferase family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	12
+NX_Q93073	Selenocysteine insertion sequence-binding protein 2-like	1101	121776	5.76	0	Nucleoplasm	NA	Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro.	NA	NA	NA	PE1	15
+NX_Q93074	Mediator of RNA polymerase II transcription subunit 12	2177	243081	6.63	0	Nucleoplasm;Nucleus	Ohdo syndrome, X-linked;Opitz-Kaveggia syndrome;Lujan-Fryns syndrome	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.	NA	Belongs to the Mediator complex subunit 12 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	X
+NX_Q93075	Putative deoxyribonuclease TATDN2	761	85023	7.07	0	Nucleus speckle;Nucleus	NA	Putative deoxyribonuclease.	NA	Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.	XBP1(S) activates chaperone genes	PE1	3
+NX_Q93077	Histone H2A type 1-C	130	14105	11.05	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Deiminated on Arg-4 in granulocytes upon calcium entry.;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.;Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.;Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).	Belongs to the histone H2A family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;RMTs methylate histone arginines;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_Q93079	Histone H2B type 1-H	126	13892	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (PubMed:16627869). Monoubiquitinated by DTX3L upon encephalomyocarditis virus (EMCV)-mediated infection (PubMed:26479788).;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.;GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_Q93083	Metallothionein-1L	61	6062	8.38	0	NA	NA	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	NA	Belongs to the metallothionein superfamily. Type 1 family.	NA	PE1	16
+NX_Q93084	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	1043	113977	5.42	10	Endoplasmic reticulum membrane;Nucleus membrane;Sarcoplasmic reticulum membrane	NA	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.	Calcium signaling pathway;Pancreatic secretion;Alzheimer's disease;Ion transport by P-type ATPases;Pre-NOTCH Processing in Golgi;Reduction of cytosolic Ca++ levels;Ion homeostasis	PE1	17
+NX_Q93086	P2X purinoceptor 5	422	47205	7.46	2	Membrane;Cytosol	NA	Receptor for ATP that acts as a ligand-gated ion channel.	NA	Belongs to the P2X receptor family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Elevation of cytosolic Ca2+ levels;Platelet homeostasis	PE1	17
+NX_Q93088	Betaine--homocysteine S-methyltransferase 1	406	44998	6.58	0	Cytoplasm;Cytosol	NA	Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.	NA	NA	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.;Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.;Glycine, serine and threonine metabolism;Cysteine and methionine metabolism;Metabolic pathways;Sulfur amino acid metabolism;Choline catabolism	PE1	5
+NX_Q93091	Ribonuclease K6	150	17196	9.09	0	Cytoplasmic granule;Secreted;Lysosome	NA	Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:8836175, PubMed:27013146). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:27089320).	NA	Belongs to the pancreatic ribonuclease family.	Antimicrobial peptides	PE1	14
+NX_Q93096	Protein tyrosine phosphatase type IVA 1	173	19815	9.17	0	Cytoplasm;Cell membrane;Early endosome;Endoplasmic reticulum;Spindle	NA	Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.	Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.	Belongs to the protein-tyrosine phosphatase family.	NA	PE1	6
+NX_Q93097	Protein Wnt-2b	391	43770	9.32	0	Nucleoplasm;Extracellular matrix;Secreted;Cytoplasmic vesicle	Diarrhea 9	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors)	PE1	1
+NX_Q93098	Protein Wnt-8b	351	38721	8.93	0	Extracellular matrix	NA	Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.	Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.;Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors);TCF dependent signaling in response to WNT;Disassembly of the destruction complex and recruitment of AXIN to the membrane	PE2	10
+NX_Q93099	Homogentisate 1,2-dioxygenase	445	49964	6.5	0	Golgi apparatus	Alkaptonuria	NA	NA	Belongs to the homogentisate dioxygenase family.	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.;Tyrosine metabolism;Metabolic pathways;Tyrosine catabolism	PE1	3
+NX_Q93100	Phosphorylase b kinase regulatory subunit beta	1093	124884	6.5	0	Golgi apparatus;Cell membrane	Glycogen storage disease 9B	Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation.	Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.;Ser-701 is probably phosphorylated by PKA.;PHKB is phosphorylated by PASK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the phosphorylase b kinase regulatory chain family.	Glycan biosynthesis; glycogen metabolism.;Calcium signaling pathway;Insulin signaling pathway;Glycogen breakdown (glycogenolysis)	PE1	16
+NX_Q95460	Major histocompatibility complex class I-related gene protein	341	39366	5.87	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Secreted;Cell membrane	NA	Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.	N-glycosylated.	Belongs to the MHC class I family.	NA	PE1	1
+NX_Q95IE3	HLA class II histocompatibility antigen, DRB1-12 beta chain	266	29878	7.69	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;trans-Golgi network membrane;Lysosome membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_Q969D9	Thymic stromal lymphopoietin	159	18141	9.75	0	Golgi apparatus;Secreted;Cytoplasmic vesicle	NA	Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.;May act as an antimicrobial peptide in the oral cavity and on the skin.	NA	NA	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-7 signaling	PE1	5
+NX_Q969E1	Liver-expressed antimicrobial peptide 2	77	8814	10.31	0	Secreted	NA	Has an antimicrobial activity.	NA	Belongs to the LEAP2 family.	Antimicrobial peptides	PE1	5
+NX_Q969E2	Secretory carrier-associated membrane protein 4	229	25728	9.07	4	Golgi apparatus;Cell membrane;Lipid droplet;Membrane;Cytoplasmic vesicle	NA	Probably involved in membrane protein trafficking.	NA	Belongs to the SCAMP family.	NA	PE1	19
+NX_Q969E3	Urocortin-3	161	17961	10.41	0	Secreted	NA	Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.	NA	Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	Class B/2 (Secretin family receptors)	PE1	10
+NX_Q969E4	Transcription elongation factor A protein-like 3	200	22502	4.85	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the TFS-II family. TFA subfamily.	NA	PE1	X
+NX_Q969E8	Pre-rRNA-processing protein TSR2 homolog	191	20894	4.25	0	Nucleoplasm;Cytosol;Cell junction;Nucleolus	Diamond-Blackfan anemia 14, with mandibulofacial dysostosis	May be involved in 20S pre-rRNA processing.	NA	Belongs to the TSR2 family.	NA	PE1	X
+NX_Q969F0	Fetal and adult testis-expressed transcript protein	183	20712	9.51	1	Mitochondrion outer membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane;Mitochondrion	NA	Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).	NA	NA	NA	PE1	X
+NX_Q969F1	General transcription factor 3C polypeptide 6	213	24049	4.13	0	Nucleoplasm;Nucleus	NA	Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.	NA	Belongs to the TFIIIC subunit 6 family.	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter	PE1	6
+NX_Q969F2	Protein naked cuticle homolog 2	451	50055	7.83	0	Cytoplasmic vesicle;Cytoplasm;Cell membrane	NA	Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.	Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25.	Belongs to the NKD family.	Wnt signaling pathway	PE1	5
+NX_Q969F8	KiSS-1 receptor	398	42586	9.93	7	Cytoplasmic vesicle;Cell membrane	Precocious puberty, central 1;Hypogonadotropic hypogonadism 8 with or without anosmia	Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	19
+NX_Q969F9	Hermansky-Pudlak syndrome 3 protein	1004	113736	6.01	0	Golgi apparatus;Cytoplasm;Cytosol;Cell membrane	Hermansky-Pudlak syndrome 3	Involved in early stages of melanosome biogenesis and maturation.	NA	NA	NA	PE1	3
+NX_Q969G2	LIM/homeobox protein Lhx4	390	43124	7.52	0	Nucleus speckle;Nucleus	Pituitary hormone deficiency, combined, 4	May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536).	NA	NA	Regulation of expression of SLITs and ROBOs	PE1	1
+NX_Q969G3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1	411	46649	4.85	0	Nucleoplasm;Nucleus	Coffin-Siris syndrome 5;Meningioma	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.	Ubiquitinated by TRIP12, leading to its degradation by the proteasome. Ubiquitination is prevented upon interaction between TRIP12 and SMARCC1.	NA	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	17
+NX_Q969G5	Caveolae-associated protein 3	261	27701	6.05	0	Cytoplasm;Cytosol;Caveola;Cell membrane	NA	Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).	In vitro, phosphorylated by PRKCD.	Belongs to the CAVIN family.	NA	PE1	11
+NX_Q969G6	Riboflavin kinase	155	17623	7.85	0	Golgi apparatus;Cytoplasm	NA	Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.	NA	NA	Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.;Riboflavin metabolism;Metabolic pathways;Vitamin B2 (riboflavin) metabolism	PE1	9
+NX_Q969G9	Protein naked cuticle homolog 1	470	52285	8.82	0	Cytoplasm;Nucleolus;Cell membrane	NA	Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.	NA	Belongs to the NKD family.	Wnt signaling pathway	PE1	16
+NX_Q969H0	F-box/WD repeat-containing protein 7	707	79663	5.5	0	Cytoplasmic vesicle;Nucleoplasm;Cytoplasm;Nucleolus	NA	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018).	Phosphorylation at Thr-205 promotes interaction with PIN1, leading to disrupt FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation (PubMed:22608923).;Ubiquitinated: autoubiquitinates following phosphorylation at Thr-205 and subsequent interaction with PIN1. Ubiquitination leads to its proteasomal degradation (PubMed:22608923).	NA	Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Association of TriC/CCT with target proteins during biosynthesis;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;Neddylation;Regulation of RUNX2 expression and activity;Negative regulation of NOTCH4 signaling	PE1	4
+NX_Q969H4	Connector enhancer of kinase suppressor of ras 1	720	79706	5.22	0	Membrane;Cytoplasm;Cytosol	NA	May function as an adapter protein or regulator of Ras signaling pathways.	Phosphorylated on tyrosine.	Belongs to the CNKSR family.	MAP2K and MAPK activation;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	1
+NX_Q969H6	Ribonuclease P/MRP protein subunit POP5	163	18820	6.89	0	Nucleoplasm;Nucleolus	NA	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:11413139, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).	NA	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.	Ribosome biogenesis in eukaryotes;RNA transport;tRNA processing in the nucleus	PE1	12
+NX_Q969H8	Myeloid-derived growth factor	173	18795	6.2	0	Golgi apparatus;Endoplasmic reticulum;Secreted;Endoplasmic reticulum-Golgi intermediate compartment	NA	Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).	NA	Belongs to the MYDGF family.	XBP1(S) activates chaperone genes	PE1	19
+NX_Q969H9	Disrupted in renal carcinoma protein 1	104	11440	8.68	0	Nucleoplasm	NA	NA	NA	NA	NA	PE2	2
+NX_Q969I3	Glycine N-acyltransferase-like protein 1	302	35101	6.41	0	NA	NA	Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.	NA	Belongs to the glycine N-acyltransferase family.	Conjugation of salicylate with glycine;Conjugation of benzoate with glycine	PE1	11
+NX_Q969I6	Sodium-coupled neutral amino acid transporter 4	547	60764	6.02	10	Cell membrane	NA	Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.	The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface.	Belongs to the amino acid/polyamine transporter 2 family.	Amino acid transport across the plasma membrane	PE1	12
+NX_Q969J2	Zinc finger protein with KRAB and SCAN domains 4	545	61579	7.56	0	Nucleus	NA	May be involved in the transcriptional activation of MDM2 and EP300 genes.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	6
+NX_Q969J3	BLOC-1-related complex subunit 5	196	22222	5.97	0	Cytosol;Lysosome membrane	NA	As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility.	Myristoylation at Gly-2 mediates attachment to lysosome membranes.	Belongs to the BORCS5 family.	NA	PE1	12
+NX_Q969J5	Interleukin-22 receptor subunit alpha-2	263	30550	8.31	0	Secreted	NA	May play a role in establishing and maintaining successful pregnancy.;Is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.	NA	Belongs to the type II cytokine receptor family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling	PE1	6
+NX_Q969K3	E3 ubiquitin-protein ligase RNF34	372	41641	4.83	0	Nucleus speckle;Cell membrane;Endomembrane system;Nucleoplasm;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).	Proteolytically cleaved by caspases upon induction of apoptosis by TNF.;Autoubiquitinated (in vitro).	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Regulation of TP53 Degradation	PE1	12
+NX_Q969K4	Ankyrin repeat and BTB/POZ domain-containing protein 1	478	53979	5.15	0	Cytoplasm;Cytosol;Nucleolus	NA	May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes.	NA	NA	NA	PE1	3
+NX_Q969K7	Transmembrane protein 54	222	23772	8.06	4	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the TMEM54 family.	NA	PE1	1
+NX_Q969L2	Protein MAL2	176	19125	5.76	4	Apical cell membrane;Endomembrane system;Perinuclear region;Cell membrane	NA	Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.	NA	Belongs to the MAL family.	NA	PE1	8
+NX_Q969L4	U7 snRNA-associated Sm-like protein LSm10	123	14080	9.3	0	Nucleoplasm;Nucleus	NA	Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.	Not methylated. Methylation is not necessary for interaction with SMN.	Belongs to the snRNP Sm proteins family.	SLBP independent Processing of Histone Pre-mRNAs;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	1
+NX_Q969M1	Mitochondrial import receptor subunit TOM40B	308	33917	6.73	0	Mitochondrion outer membrane;Cytoplasm;Nucleus	NA	Potential channel-forming protein implicated in import of protein precursors into mitochondria.	NA	Belongs to the Tom40 family.	Amyotrophic lateral sclerosis (ALS)	PE1	1
+NX_Q969M2	Gap junction alpha-10 protein	543	61872	7.89	4	Gap junction;Cell membrane	NA	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity).	NA	Belongs to the connexin family. Alpha-type (group II) subfamily.	Electric Transmission Across Gap Junctions;Gap junction assembly	PE2	6
+NX_Q969M3	Protein YIPF5	257	27989	4.18	5	Golgi apparatus;Endoplasmic reticulum membrane;cis-Golgi network membrane;COPII-coated vesicle;Endoplasmic reticulum;Nucleoplasm;Cytoplasmic vesicle	NA	Plays a role in transport between endoplasmic reticulum and Golgi.	NA	Belongs to the YIP1 family.	NA	PE1	5
+NX_Q969M7	NEDD8-conjugating enzyme UBE2F	185	21077	6.31	0	Cytosol	NA	Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.	The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.	Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.	Protein modification; protein neddylation.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	2
+NX_Q969N2	GPI transamidase component PIG-T	578	65700	8.64	1	Endoplasmic reticulum membrane	Multiple congenital anomalies-hypotonia-seizures syndrome 3;Paroxysmal nocturnal hemoglobinuria 2	Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.	The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity.	Belongs to the PIGT family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Attachment of GPI anchor to uPAR	PE1	20
+NX_Q969N4	Trace amine-associated receptor 8	342	38029	6.42	7	Cell membrane	NA	Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Amine ligand-binding receptors	PE2	6
+NX_Q969P0	Immunoglobulin superfamily member 8	613	65034	8.23	1	Cytoplasmic vesicle;Cell membrane	NA	May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.	NA	NA	NA	PE1	1
+NX_Q969P5	F-box only protein 32	355	41637	9.45	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	8
+NX_Q969P6	DNA topoisomerase I, mitochondrial	601	69872	9.46	0	Mitochondrion	NA	Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).	NA	Belongs to the type IB topoisomerase family.	NA	PE1	8
+NX_Q969Q0	60S ribosomal protein L36a-like	106	12469	10.67	0	Cytoplasm	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL42 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	14
+NX_Q969Q1	E3 ubiquitin-protein ligase TRIM63	353	40248	4.85	0	Cytoplasm;Z line;M line;Nucleus	NA	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	1
+NX_Q969Q4	ADP-ribosylation factor-like protein 11	196	21391	5.96	0	NA	Leukemia, chronic lymphocytic	May play a role in apoptosis. May act as a tumor suppressor.	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	13
+NX_Q969Q5	Ras-related protein Rab-24	203	23124	5.85	0	Membrane;Cytosol;Focal adhesion	NA	May be involved in autophagy-related processes.	Isoprenylation is inefficient compared to other Rab family members.	Belongs to the small GTPase superfamily. Rab family.	Neutrophil degranulation;RAB geranylgeranylation	PE1	5
+NX_Q969Q6	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma	453	53316	5.07	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol;Nucleus	Spermatogenic failure 36;Gonadal dysgenesis, dysmorphic facies, retinal dystrophy, and myopathy	May regulate MCM3AP phosphorylation through phosphatase recruitment (By similarity). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (PubMed:24333728). May play a role in the activation-induced cell death of B-cells (By similarity).	NA	NA	mRNA surveillance pathway;Dopaminergic synapse	PE1	14
+NX_Q969R2	Oxysterol-binding protein 2	916	101266	6.1	0	Membrane;Cytosol	NA	Binds 7-ketocholesterol.	NA	Belongs to the OSBP family.	NA	PE1	22
+NX_Q969R5	Lethal(3)malignant brain tumor-like protein 2	705	79110	6.4	0	Nucleoplasm;Nucleus	NA	Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.	NA	NA	SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6	PE1	22
+NX_Q969R8	KICSTOR complex protein ITFG2	447	49313	5.06	0	Endoplasmic reticulum;Nucleoplasm;Lysosome membrane;Cytoskeleton	NA	As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	NA	NA	NA	PE1	12
+NX_Q969S0	UDP-xylose and UDP-N-acetylglucosamine transporter	331	37424	9.24	11	Golgi apparatus membrane	NA	Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.	NA	Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.	Transport of nucleotide sugars	PE1	7
+NX_Q969S2	Endonuclease 8-like 2	332	36826	6.32	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	NA	Belongs to the FPG family.	Base excision repair;APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine	PE1	8
+NX_Q969S3	Zinc finger protein 622	477	54272	5.8	0	Golgi apparatus;Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.	Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.;ZNF622 is phosphorylated by MELK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	5
+NX_Q969S6	Transmembrane protein 203	136	15760	8.8	4	Endoplasmic reticulum membrane	NA	Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873).	NA	NA	NA	PE1	9
+NX_Q969S8	Polyamine deacetylase HDAC10	669	71445	5.44	0	Cytoplasm;Nucleus	NA	Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039).	NA	Belongs to the histone deacetylase family. HD type 2 subfamily.	HDACs deacetylate histones;Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	PE1	22
+NX_Q969S9	Ribosome-releasing factor 2, mitochondrial	779	86601	6.08	0	Nucleoplasm;Mitochondrion	Combined oxidative phosphorylation deficiency 39	Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.	Mitochondrial translation termination	PE1	5
+NX_Q969T3	Sorting nexin-21	373	41365	5.11	0	Early endosome membrane;Cytoplasmic vesicle;Centriolar satellite;Cytoplasmic vesicle membrane	NA	Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking.	NA	Belongs to the sorting nexin family.	NA	PE1	20
+NX_Q969T4	Ubiquitin-conjugating enzyme E2 E3	207	22913	6.73	0	Cytoplasm;Nucleus	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.	NA	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	2
+NX_Q969T7	7-methylguanosine phosphate-specific 5'-nucleotidase	300	34389	5.95	0	Cytoplasm	NA	Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).	NA	Belongs to the pyrimidine 5'-nucleotidase family.	mRNA decay by 3' to 5' exoribonuclease	PE1	17
+NX_Q969T9	WW domain-binding protein 2	261	28087	5.65	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Deafness, autosomal recessive, 107	Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Required for YAP1 coactivation function on PGR activity (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).	Phosphorylated in repsonse to EGF as well as estrogen and progesterone hormones (PubMed:21642474). Tyr-192 and Tyr-231 are phosphorylated by YES and SRC inducing nuclear translocation (PubMed:21642474).	NA	NA	PE1	17
+NX_Q969U6	F-box/WD repeat-containing protein 5	566	63922	5.89	0	Cytoplasm;Mitochondrion	NA	Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.	Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase.;Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS6.	Belongs to the FBXW5 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Association of TriC/CCT with target proteins during biosynthesis;Neddylation	PE1	9
+NX_Q969U7	Proteasome assembly chaperone 2	264	29396	6.61	0	Nucleoplasm;Nucleus	NA	Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.	Degraded by the proteasome upon completion of 20S proteasome maturation.	Belongs to the PSMG2 family.	NA	PE1	18
+NX_Q969V1	Melanin-concentrating hormone receptor 2	340	38849	9.09	7	Cell membrane	NA	Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	6
+NX_Q969V3	Nicalin	563	62974	6.4	1	Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum membrane;Lipid droplet	NA	May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.	NA	Belongs to the nicastrin family.	NA	PE1	19
+NX_Q969V4	Tektin-1	418	48283	5.98	0	Flagellum axoneme;Cilium axoneme	NA	Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.	NA	Belongs to the tektin family.	NA	PE1	17
+NX_Q969V5	Mitochondrial ubiquitin ligase activator of NFKB 1	352	39800	8.46	2	Mitochondrion outer membrane;Mitochondrion;Nucleoplasm;Peroxisome;Cytosol	NA	Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697).	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	NA	Protein modification; protein ubiquitination.;Protein modification; protein sumoylation.;Ub-specific processing proteases	PE1	1
+NX_Q969V6	Myocardin-related transcription factor A	931	98919	5.59	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.	Phosphorylation at Ser-6 by Erk inhibits binding of globular actin (G-actin), unmasking the nuclear localization signal (NLS) and promoting nuclear import.	NA	RHO GTPases Activate Formins;SUMOylation of transcription cofactors	PE1	22
+NX_Q969W0	Serine palmitoyltransferase small subunit A	71	8466	6.7	2	Endoplasmic reticulum membrane	NA	Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19416851). Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI) (PubMed:23510452).	NA	Belongs to the SPTSS family. SPTSSA subfamily.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid de novo biosynthesis	PE1	14
+NX_Q969W1	Palmitoyltransferase ZDHHC16	377	43633	9.71	4	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane;Nucleus membrane	NA	Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:28826475). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).	NA	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	10
+NX_Q969W3	Protein FAM104A	186	19484	11.26	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the FAM104 family.	NA	PE1	17
+NX_Q969W8	Zinc finger protein 566	418	49219	8.36	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q969W9	Protein TMEPAI	287	31609	6.41	1	Early endosome membrane;Cytoplasmic vesicle;Golgi apparatus membrane	NA	Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).	NA	Belongs to the PMEPA1 family.	Downregulation of TGF-beta receptor signaling	PE1	20
+NX_Q969X0	RILP-like protein 2	211	23986	4.95	0	Cytosol;Centrosome;Cilium	NA	Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). May function via activation of RAC1 and PAK1 (By similarity).	NA	Belongs to the RILPL family.	NA	PE1	12
+NX_Q969X1	Protein lifeguard 3	311	34607	7.6	7	Membrane;Cytoplasmic vesicle;Lysosome membrane;Endosome membrane	NA	Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.	NA	Belongs to the BI1 family. LFG subfamily.	Neutrophil degranulation	PE1	2
+NX_Q969X2	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	333	38068	9.91	1	Golgi apparatus membrane	NA	Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)).	NA	Belongs to the glycosyltransferase 29 family.	Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Sialic acid metabolism;Lewis blood group biosynthesis	PE1	9
+NX_Q969X5	Endoplasmic reticulum-Golgi intermediate compartment protein 1	290	32592	6.59	2	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane;Nucleoplasm;Centrosome;Golgi apparatus membrane;Cytoplasmic vesicle	Arthrogryposis multiplex congenita, neurogenic type	Possible role in transport between endoplasmic reticulum and Golgi.	N-glycosylated.	Belongs to the ERGIC family.	NA	PE1	5
+NX_Q969X6	U3 small nucleolar RNA-associated protein 4 homolog	686	76890	9.03	0	Nucleolus;Chromosome	NA	Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766). May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (PubMed:19732766).	May be phosphorylated during mitosis; may control the association of this protein with WRD43 and UTP15.	NA	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	16
+NX_Q969Y0	NXPE family member 3	559	63800	9.05	0	Nucleoplasm;Secreted;Cytoplasmic vesicle	NA	NA	NA	Belongs to the NXPE family.	NA	PE1	3
+NX_Q969Y2	tRNA modification GTPase GTPBP3, mitochondrial	492	52058	6.03	0	Mitochondrion	Combined oxidative phosphorylation deficiency 23	GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.	tRNA modification in the mitochondrion	PE1	19
+NX_Q969Z0	FAST kinase domain-containing protein 4	631	70738	6.98	0	Mitochondrion matrix;Mitochondrion	NA	Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed:9383053).	NA	Belongs to the FAST kinase family.	NA	PE1	7
+NX_Q969Z3	Mitochondrial amidoxime reducing component 2	335	38023	9.32	0	Mitochondrion outer membrane;Peroxisome;Mitochondrion	NA	As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	NA	Phase I - Functionalization of compounds	PE1	1
+NX_Q969Z4	Tumor necrosis factor receptor superfamily member 19L	430	46092	8.75	1	Nucleoplasm;Cytoplasm;Perinuclear region;Cell membrane	Amelogenesis imperfecta 3C	May play a role in apoptosis (PubMed:28688764, PubMed:19969290). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727). Involved in dental enamel formation (PubMed:30506946).	Phosphorylated in vitro by OXSR1 (PubMed:16389068). Phosphorylated by STK39 (PubMed:16530727).;RELT is phosphorylated by STK39 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the RELT family.	Cytokine-cytokine receptor interaction	PE1	11
+NX_Q96A00	Protein phosphatase 1 regulatory subunit 14A	147	16693	9.41	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.	NA	Belongs to the PP1 inhibitor family.	Vascular smooth muscle contraction;RHO GTPases activate PKNs	PE1	19
+NX_Q96A04	TSSK6-activating co-chaperone protein	125	13670	9.18	0	Nucleoplasm;Nucleus	NA	Co-chaperone that facilitates HSP-mediated activation of TSSK6.	NA	Belongs to the TSACC family.	NA	PE1	1
+NX_Q96A05	V-type proton ATPase subunit E 2	226	26074	8.79	0	NA	NA	Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity).	NA	Belongs to the V-ATPase E subunit family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	2
+NX_Q96A08	Histone H2B type 1-A	127	14167	10.31	0	Nucleus;Chromosome	NA	Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133).	Methylated at Lys-118 in spermatogonia, spermatocytes and round spermatids.;Acetylated during spermatogenesis. Acetylated form is most abundant in spermatogonia compared to spermatocytes and round spermatids (By similarity).;Phosphorylated at Thr-117 in spermatogonia, spermatocytes and round spermatids.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Monoubiquitination at Lys-36 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_Q96A09	Terminal nucleotidyltransferase 5B	425	46688	8.39	0	NA	NA	Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.	NA	Belongs to the TENT family.	NA	PE1	1
+NX_Q96A11	Galactose-3-O-sulfotransferase 3	431	48956	9.96	1	Golgi stack membrane	NA	Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc.	NA	Belongs to the galactose-3-O-sulfotransferase family.	Protein modification; carbohydrate sulfation.	PE1	11
+NX_Q96A19	Coiled-coil domain-containing protein 102A	550	62596	5.49	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	16
+NX_Q96A22	Uncharacterized protein C11orf52	123	13921	9.51	0	Cell junction	NA	NA	NA	NA	NA	PE1	11
+NX_Q96A23	Copine-4	557	62395	5.92	0	Nucleoplasm;Cytosol	NA	Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.	NA	Belongs to the copine family.	NA	PE1	3
+NX_Q96A25	Transmembrane protein 106A	262	28920	6.74	1	Cell membrane	NA	Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:30456879, PubMed:29131025).	NA	Belongs to the TMEM106 family.	NA	PE1	17
+NX_Q96A26	Protein FAM162A	154	17342	9.81	1	Membrane;Cytosol;Mitochondrion	NA	Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.	NA	Belongs to the UPF0389 family.	NA	PE1	3
+NX_Q96A28	SLAM family member 9	289	32436	7.58	1	Membrane	NA	May play a role in the immune response.	NA	NA	NA	PE2	1
+NX_Q96A29	GDP-fucose transporter 1	364	39809	8.66	8	Golgi apparatus;Golgi apparatus membrane	Congenital disorder of glycosylation 2C	Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.	NA	Belongs to the TPT transporter family. SLC35C subfamily.	Transport of nucleotide sugars;Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C);GDP-fucose biosynthesis	PE1	11
+NX_Q96A32	Myosin regulatory light chain 2, skeletal muscle isoform	169	19015	4.91	0	NA	NA	NA	NA	NA	Focal adhesion;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Smooth Muscle Contraction	PE1	16
+NX_Q96A33	Coiled-coil domain-containing protein 47	483	55874	4.76	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Rough endoplasmic reticulum membrane	Trichohepatoneurodevelopmental syndrome	Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (PubMed:30401460). Required for proper protein degradation via the ERAD pathway (PubMed:25009997). Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis (By similarity).	NA	NA	NA	PE1	17
+NX_Q96A35	39S ribosomal protein L24, mitochondrial	216	24915	9.33	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL24 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	1
+NX_Q96A37	E3 ubiquitin-protein ligase RNF166	237	26122	8.42	0	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	NA	E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896). In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896). Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228). Plays also a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896). Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896).	NA	NA	Protein modification; protein ubiquitination.	PE1	16
+NX_Q96A44	SPRY domain-containing SOCS box protein 4	273	30179	9.39	0	Nucleoplasm;Golgi apparatus;Cytosol;Cytoplasm	NA	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558).	NA	Belongs to the SPSB family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	3
+NX_Q96A46	Mitoferrin-2	364	39272	8.86	6	Mitochondrion inner membrane	NA	Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Mitochondrial iron-sulfur cluster biogenesis	PE1	10
+NX_Q96A47	Insulin gene enhancer protein ISL-2	359	39768	8.64	0	Cytoplasm;Nucleus	NA	Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.	NA	NA	NA	PE1	15
+NX_Q96A49	Synapse-associated protein 1	352	39933	4.45	0	Golgi apparatus;Presynaptic cell membrane;Postsynaptic cell membrane;Perikaryon;Growth cone;Membrane;Nucleoplasm;Dendrite;Cytosol;Axon;Perinuclear region	NA	Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339).	Phosphorylated. Phosphorylation increases in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation.	NA	NA	PE1	X
+NX_Q96A54	Adiponectin receptor protein 1	375	42616	6.53	7	Cell membrane	NA	Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).	NA	Belongs to the ADIPOR family.	Adipocytokine signaling pathway;AMPK inhibits chREBP transcriptional activation activity	PE1	1
+NX_Q96A56	Tumor protein p53-inducible nuclear protein 1	240	27366	4.75	0	Cytosol;Autophagosome;PML body;Nucleus	NA	Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.	NA	NA	HTLV-I infection;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;Regulation of TP53 Activity through Phosphorylation	PE1	8
+NX_Q96A57	Transmembrane protein 230	120	13188	9.3	2	trans-Golgi network;Recycling endosome;Early endosome;Membrane;Endoplasmic reticulum;Autophagosome;Late endosome;Synaptic vesicle	Parkinson disease	Involved in trafficking and recycling of synaptic vesicles.	NA	Belongs to the TMEM134/TMEM230 family.	NA	PE1	20
+NX_Q96A58	Ras-related and estrogen-regulated growth inhibitor	199	22608	6.91	0	Cytoplasm	NA	Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.	NA	Belongs to the small GTPase superfamily. Ras family.	NA	PE1	12
+NX_Q96A59	MARVEL domain-containing protein 3	401	44911	8.84	4	Membrane;Cytoplasmic vesicle;Tight junction;Cytoskeleton	NA	As a component of tight junctions, plays a role in paracellular ion conductivity.	NA	NA	NA	PE1	16
+NX_Q96A61	Tripartite motif-containing protein 52	297	34653	4.14	0	Nucleolus;Cytoskeleton	NA	NA	Ubiquitinated.	Belongs to the TRIM/RBCC family.	NA	PE1	5
+NX_Q96A65	Exocyst complex component 4	974	110498	6.07	0	Cytoplasm;Cell projection;Nucleolus;Nucleoplasm;Cytosol;Midbody ring	NA	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	NA	Belongs to the SEC8 family.	Tight junction;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium	PE1	7
+NX_Q96A70	Antizyme inhibitor 2	460	49980	5.4	0	trans-Golgi network;Cytoplasm;Perinuclear region;Endoplasmic reticulum-Golgi intermediate compartment;Cytoplasmic granule;Perikaryon;Membrane;cis-Golgi network;Cytoplasmic vesicle;Cytosol;Axon;Dendrite;Nucleus	NA	Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).	Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteasomal-independent manner.	Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.	Arginine and proline metabolism;Metabolic pathways;Agmatine biosynthesis	PE1	1
+NX_Q96A72	Protein mago nashi homolog 2	148	17276	5.96	0	Nucleus	NA	Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961, PubMed:30705154). Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022).	NA	Belongs to the mago nashi family.	RNA transport;mRNA surveillance pathway;Spliceosome;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Regulation of expression of SLITs and ROBOs;RNA Polymerase II Transcription Termination	PE1	12
+NX_Q96A73	Putative monooxygenase p33MONOX	305	33247	9.39	0	Cytoplasm;Nucleoplasm	NA	Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.	NA	Belongs to the P33MONOX family.	NA	PE1	5
+NX_Q96A83	Collagen alpha-1(XXVI) chain	441	45381	7.02	0	Cytoplasmic vesicle;Extracellular matrix	NA	NA	Hydroxylated on proline residues.	NA	Collagen degradation;Collagen biosynthesis and modifying enzymes;Collagen chain trimerization	PE1	7
+NX_Q96A84	EMI domain-containing protein 1	441	45292	9.31	0	Extracellular matrix	NA	NA	NA	NA	NA	PE1	22
+NX_Q96A98	Tuberoinfundibular peptide of 39 residues	100	11202	11.83	0	Secreted	NA	Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.	NA	Belongs to the parathyroid hormone family.	G alpha (s) signalling events;Class B/2 (Secretin family receptors)	PE1	19
+NX_Q96A99	Pentraxin-4	478	52339	9.64	0	Secreted	NA	NA	NA	NA	NA	PE2	16
+NX_Q96AA3	Protein RFT1 homolog	541	60335	9.07	12	Membrane;Cytoplasmic vesicle	Congenital disorder of glycosylation 1N	May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.	NA	Belongs to the RFT1 family.	N-Glycan biosynthesis;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective RFT1 causes RFT1-CDG (CDG-1n)	PE1	3
+NX_Q96AA8	Janus kinase and microtubule-interacting protein 2	810	94934	5.88	0	Golgi apparatus	NA	NA	NA	Belongs to the JAKMIP family.	NA	PE1	5
+NX_Q96AB3	Isochorismatase domain-containing protein 2	205	22337	7.67	0	Cytoplasm;Cytosol;Mitochondrion;Nucleus	NA	NA	NA	Belongs to the isochorismatase family.	NA	PE1	19
+NX_Q96AB6	Protein N-terminal asparagine amidohydrolase	310	34677	5.82	0	Golgi apparatus;Cytoplasm;Nucleoplasm	NA	N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.	NA	NA	NA	PE1	16
+NX_Q96AC1	Fermitin family homolog 2	680	77861	6.26	0	Cytoplasm;Cell cortex;Focal adhesion;Lamellipodium membrane;Cell surface;Membrane;Stress fiber;Nucleoplasm;Nucleus;I band;Cytoskeleton	NA	Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.	NA	Belongs to the kindlin family.	Cell-extracellular matrix interactions	PE1	14
+NX_Q96AC6	Kinesin-like protein KIFC2	838	90147	9.62	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	8
+NX_Q96AD5	Patatin-like phospholipase domain-containing protein 2	504	55316	6.65	1	Nucleoplasm;Cell membrane;Lipid droplet	Neutral lipid storage disease with myopathy	Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.	Phosphorylation at Ser-404 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity (By similarity). Phosphorylation at Ser-404 is increased upon beta-adrenergic stimulation.	NA	Glycerolipid metabolism; triacylglycerol degradation.;Acyl chain remodeling of DAG and TAG;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	11
+NX_Q96AE4	Far upstream element-binding protein 1	644	67560	7.18	0	Nucleoplasm;Nucleus	NA	Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.	Ubiquitinated. This targets the protein for proteasome-mediated degradation.	NA	NA	PE1	1
+NX_Q96AE7	Tetratricopeptide repeat protein 17	1141	129558	6.11	0	Cytoplasm;Cytosol;Cytoskeleton;Cell membrane	NA	Plays a role in primary ciliogenesis by modulating actin polymerization.	NA	Belongs to the TTC17 family.	NA	PE1	11
+NX_Q96AG3	Solute carrier family 25 member 46	418	46174	6.97	6	Mitochondrion outer membrane;Mitochondrion	Neuropathy, hereditary motor and sensory, 6B	May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	5
+NX_Q96AG4	Leucine-rich repeat-containing protein 59	307	34930	9.61	1	Microsome membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane;Nucleus envelope	NA	Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.	NA	NA	NA	PE1	17
+NX_Q96AH0	SOSS complex subunit B2	204	22423	9.63	0	Nucleoplasm;Cytosol;Nucleus	NA	Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.	NA	Belongs to the SOSS-B family. SOSS-B2 subfamily.	RNA polymerase II transcribes snRNA genes	PE1	2
+NX_Q96AH8	Ras-related protein Rab-7b	199	22511	6.31	0	trans-Golgi network;Golgi apparatus;Phagosome membrane;Phagosome;Late endosome;Lysosome	NA	Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.	NA	Belongs to the small GTPase superfamily. Rab family.	Phagosome;Salmonella infection;Amoebiasis;RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs;RAB geranylgeranylation	PE1	1
+NX_Q96AJ1	Clusterin-associated protein 1	413	48125	4.68	0	Cytoplasmic vesicle;Nucleoplasm;Cilium;Nucleus	NA	Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling.	NA	Belongs to the CLUAP1 family.	Intraflagellar transport	PE1	16
+NX_Q96AJ9	Vesicle transport through interaction with t-SNAREs homolog 1A	217	25218	6.06	1	Golgi apparatus;Cytoplasmic vesicle;Golgi apparatus membrane	NA	V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.	NA	Belongs to the VTI1 family.	SNARE interactions in vesicular transport;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network	PE1	10
+NX_Q96AK3	DNA dC->dU-editing enzyme APOBEC-3D	386	46598	8.73	0	Cytoplasm;P-body	NA	DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	NA	PE1	22
+NX_Q96AM1	Mas-related G-protein coupled receptor member F	343	38171	8.96	7	Nucleus membrane;Cell membrane	NA	Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.	NA	PE1	11
+NX_Q96AN5	Transmembrane protein 143	459	51715	9.69	2	Membrane;Nucleolus	NA	NA	NA	NA	NA	PE1	19
+NX_Q96AP0	Adrenocortical dysplasia protein homolog	458	48967	5.16	0	Telomere;Nucleus	Dyskeratosis congenita, autosomal dominant, 6;Dyskeratosis congenita, autosomal recessive, 7	Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.	NA	NA	Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine	PE1	16
+NX_Q96AP4	Zinc finger-containing ubiquitin peptidase 1	578	65959	6.05	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains (PubMed:29576528, PubMed:29563501, PubMed:29476094). Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage (PubMed:29576528, PubMed:29576527). Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress (PubMed:29563501).	NA	Belongs to the peptidase C78 family. ZUFSP subfamily.	NA	PE1	6
+NX_Q96AP7	Endothelial cell-selective adhesion molecule	390	41176	9.42	1	Tight junction;Adherens junction;Cytoskeleton;Cell membrane	NA	Can mediate aggregation most likely through a homophilic molecular interaction.	NA	NA	Cell adhesion molecules (CAMs);Leukocyte transendothelial migration;Cell surface interactions at the vascular wall	PE1	11
+NX_Q96AQ1	Coiled-coil domain-containing protein 74A	378	41605	10.52	0	Nucleus	NA	NA	NA	NA	NA	PE1	2
+NX_Q96AQ2	Transmembrane protein 125	219	22172	8.32	4	Membrane;Cytosol;Midbody	NA	NA	NA	NA	NA	PE2	1
+NX_Q96AQ6	Pre-B-cell leukemia transcription factor-interacting protein 1	731	80643	5.21	0	Cytoplasmic vesicle;Cytosol;Nucleus;Cytoskeleton	NA	Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.	NA	NA	NA	PE1	1
+NX_Q96AQ7	Cell death activator CIDE-3	238	26754	8.95	0	Endoplasmic reticulum;Nucleus;Lipid droplet	Lipodystrophy, familial partial, 5	Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.	Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life. Protein stability depends on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation (By similarity).	NA	Assembly of active LPL and LIPC lipase complexes;Lipid particle organization	PE1	3
+NX_Q96AQ8	Mitochondrial calcium uniporter regulator 1	359	39694	9.67	2	Mitochondrion inner membrane	NA	Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883). Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846).	NA	Belongs to the CCDC90 family.	NA	PE1	6
+NX_Q96AQ9	Protein FAM131C	280	30351	4.51	0	Cytosol;Nucleolus;Cytoskeleton	NA	NA	NA	Belongs to the FAM131 family.	NA	PE1	1
+NX_Q96AT1	Uncharacterized protein KIAA1143	154	17465	5.86	0	Nucleoplasm;Cytoskeleton	NA	NA	NA	NA	NA	PE1	3
+NX_Q96AT9	Ribulose-phosphate 3-epimerase	228	24928	5.33	0	NA	NA	Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.	NA	Belongs to the ribulose-phosphate 3-epimerase family.	Carbohydrate degradation.;Pentose phosphate pathway;Pentose and glucuronate interconversions;Metabolic pathways;Pentose phosphate pathway	PE1	2
+NX_Q96AV8	Transcription factor E2F7	911	99888	8.33	0	Nucleus speckle;Nucleus	NA	Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.	NA	Belongs to the E2F/DP family.	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	PE1	12
+NX_Q96AW1	Vesicular, overexpressed in cancer, prosurvival protein 1	172	19224	8.77	1	Golgi apparatus;Cytoplasmic vesicle membrane	NA	Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.	NA	Belongs to the VOPP1/ECOP family.	NA	PE1	7
+NX_Q96AX1	Vacuolar protein sorting-associated protein 33A	596	67611	6.5	0	Clathrin-coated vesicle;Early endosome;Lysosome membrane;Nucleoplasm;Autophagosome;Cytoplasmic vesicle;Late endosome membrane	Mucopolysaccharidosis-plus syndrome	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).	NA	Belongs to the STXBP/unc-18/SEC1 family.	NA	PE1	12
+NX_Q96AX2	Ras-related protein Rab-37	223	24815	5.98	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the small GTPase superfamily. Rab family.	Neutrophil degranulation;RAB geranylgeranylation	PE1	17
+NX_Q96AX9	E3 ubiquitin-protein ligase MIB2	1013	109939	8.81	0	Cytoplasm;Endosome	NA	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.	Ubiquitinated. Possibly via autoubiquitination (By similarity).	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus	PE1	1
+NX_Q96AY2	Crossover junction endonuclease EME1	570	63252	6.7	0	Nucleolus;Nucleus;Cytosol	NA	Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.	NA	Belongs to the EME1/MMS4 family.	Homologous recombination;Fanconi anemia pathway;Resolution of D-loop Structures through Holliday Junction Intermediates;Fanconi Anemia Pathway	PE1	17
+NX_Q96AY3	Peptidyl-prolyl cis-trans isomerase FKBP10	582	64245	5.36	0	Cytoplasmic vesicle;Endoplasmic reticulum lumen	Osteogenesis imperfecta 11;Bruck syndrome 1	PPIases accelerate the folding of proteins during protein synthesis.	Glycosylated and phosphorylated.	NA	NA	PE1	17
+NX_Q96AY4	Tetratricopeptide repeat protein 28	2481	270884	6.42	0	Mitochondrion;Nucleolus;Spindle pole;Centrosome;Spindle;Midbody;Cytoskeleton	NA	During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.	NA	NA	NA	PE1	22
+NX_Q96AZ1	EEF1A lysine methyltransferase 3	226	24911	5.29	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Centrosome;Nucleus	NA	Protein-lysine methyltransferase that selectively methylates EEF1A1 and EEF1A2 at 'Lys-165' in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation.	NA	Belongs to the methyltransferase superfamily. METTL21 family.	NA	PE1	12
+NX_Q96AZ6	Interferon-stimulated gene 20 kDa protein	181	20363	9.09	0	Cajal body;Cytoplasm;Nucleolus;Nucleus	NA	Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.	NA	Belongs to the exonuclease superfamily.	Interferon alpha/beta signaling	PE1	15
+NX_Q96B01	RAD51-associated protein 1	352	38457	9.18	0	Nucleoplasm;Nucleus	NA	May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA.	NA	NA	HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange	PE1	12
+NX_Q96B02	Ubiquitin-conjugating enzyme E2 W	151	17331	7.64	0	Nucleolus;Nucleus	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386, PubMed:21229326). Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini (PubMed:23560854, PubMed:23696636, PubMed:25436519). Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:19111657, PubMed:21229326). In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. Lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate (PubMed:25436519).	Autoubiquitinated at Met-1.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	8
+NX_Q96B18	Dapper homolog 3	629	64949	10.38	0	Cytoplasmic vesicle;Nucleoplasm	NA	May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.	NA	Belongs to the dapper family.	NA	PE1	19
+NX_Q96B21	Transmembrane protein 45B	275	31826	6.45	7	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the TMEM45 family.	NA	PE1	11
+NX_Q96B23	Uncharacterized protein C18orf25	404	43395	4.77	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	18
+NX_Q96B26	Exosome complex component RRP43	276	30040	5.17	0	Cytoplasmic vesicle;Nucleus;Cytoplasm;Nucleolus	Pontocerebellar hypoplasia 1C	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.	NA	Belongs to the RNase PH family.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;mRNA decay by 3' to 5' exoribonuclease;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	13
+NX_Q96B33	Claudin-23	292	31915	7.51	4	Nucleoplasm;Tight junction;Cell membrane	NA	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	8
+NX_Q96B36	Proline-rich AKT1 substrate 1	256	27383	4.65	0	Cytosol	NA	Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. MTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. MTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). MTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.	Phosphorylated by AKT1 (PubMed:12524439). Phosphorylation at Thr-246 by DYRK3 relieves inhibitory function on mTORC1 (PubMed:23415227).;AKT1S1 is phosphorylated by MAPK3	NA	HSF1-dependent transactivation;Constitutive Signaling by AKT1 E17K in Cancer;mTOR signalling;mTORC1-mediated signalling;AKT phosphorylates targets in the cytosol	PE1	19
+NX_Q96B42	Transmembrane protein 18	140	16265	9.35	3	Cytoplasm;Mitochondrion;Nucleus membrane	NA	Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).	NA	Belongs to the TMEM18 family.	NA	PE1	2
+NX_Q96B45	BLOC-1-related complex subunit 7	106	11695	6.27	0	Cytosol;Lysosome membrane;Nucleus speckle	NA	As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.	NA	Belongs to the BORCS7 family.	NA	PE1	10
+NX_Q96B49	Mitochondrial import receptor subunit TOM6 homolog	74	8002	4.66	0	Mitochondrion outer membrane;Mitochondrion	NA	NA	NA	Belongs to the Tom6 family.	Mitochondrial protein import;Pink/Parkin Mediated Mitophagy	PE1	6
+NX_Q96B54	Zinc finger protein 428	188	20481	4.14	0	Mitochondrion;Nucleolus	NA	NA	NA	NA	NA	PE1	19
+NX_Q96B67	Arrestin domain-containing protein 3	414	46395	6.16	0	Cytoplasm;Cell membrane;Early endosome;Endosome;Lysosome	NA	Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550).	NA	Belongs to the arrestin family.	NA	PE1	5
+NX_Q96B70	Leukocyte receptor cluster member 9	501	53167	8.01	0	Nucleolus	NA	NA	NA	NA	NA	PE1	19
+NX_Q96B77	Transmembrane protein 186	213	24893	9.9	2	Membrane;Cell junction;Mitochondrion	NA	NA	NA	Belongs to the TMEM186 family.	NA	PE1	16
+NX_Q96B86	Repulsive guidance molecule A	450	49347	7.18	0	Endoplasmic reticulum;Nucleoplasm;Cytosol;Cell membrane	NA	Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.	Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.	Belongs to the repulsive guidance molecule (RGM) family.	Netrin-1 signaling	PE1	15
+NX_Q96B96	Promethin	161	17522	5.05	3	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the TMEM159 family.	NA	PE1	16
+NX_Q96B97	SH3 domain-containing kinase-binding protein 1	665	73126	6.24	0	Cytoplasm;Synaptosome;Cell membrane;Focal adhesion;Cytoplasmic vesicle membrane;Cytosol;Cytoskeleton	Immunodeficiency 61	Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373).	Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus.	NA	Endocytosis;EGFR downregulation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Reelin signalling pathway;Negative regulation of MET activity;InlB-mediated entry of Listeria monocytogenes into host cell	PE1	X
+NX_Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	519	57005	5.03	1	Endoplasmic reticulum membrane;Nucleus	Osteogenesis imperfecta 16	(Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813).;Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401).	Ubiquitinated by HRD1/SYVN1; undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L1 is stabilized.;N-glycosylated.;Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2). RIP is induced by TGFB1 and ceramide (PubMed:25310401, PubMed:27499293).	Belongs to the bZIP family. ATF subfamily.	Cholinergic synapse;Dopaminergic synapse;Melanogenesis;Vasopressin-regulated water reabsorption;Huntington's disease;Prostate cancer;CREB3 factors activate genes	PE1	11
+NX_Q96BD0	Solute carrier organic anion transporter family member 4A1	722	77193	8.15	12	Cell junction;Cell membrane	NA	Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.	NA	Belongs to the organo anion transporter (TC 2.A.60) family.	Transport of organic anions	PE1	20
+NX_Q96BD5	PHD finger protein 21A	680	74854	9.51	0	Nucleoplasm;Nucleus	NA	Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.	NA	NA	Factors involved in megakaryocyte development and platelet production;HDACs deacetylate histones	PE1	11
+NX_Q96BD6	SPRY domain-containing SOCS box protein 1	273	30942	8.34	0	Cytoplasm;Cytosol	NA	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).	NA	Belongs to the SPSB family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	1
+NX_Q96BD8	Spindle and kinetochore-associated protein 1	255	29484	6.68	0	Spindle;Kinetochore;Cytoskeleton	NA	Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020).	SKA1 is phosphorylated by AURKB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the SKA1 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	18
+NX_Q96BF3	Transmembrane and immunoglobulin domain-containing protein 2	282	30675	9.13	1	Cell membrane	NA	Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.	N-glycosylated.	NA	NA	PE1	19
+NX_Q96BF6	Nucleus accumbens-associated protein 2	587	62837	5.64	0	Nucleus;Mitochondrion;Nucleolus	NA	Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.	NA	NA	NA	PE1	9
+NX_Q96BH1	E3 ubiquitin-protein ligase RNF25	459	51219	6.1	0	Nucleoplasm;Cytosol	NA	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.	Ubiquitinated.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	2
+NX_Q96BH3	Epididymal sperm-binding protein 1	223	26106	6.2	0	Secreted	NA	Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity).	N-glycosylated.	Belongs to the seminal plasma protein family.	NA	PE1	19
+NX_Q96BI1	Solute carrier family 22 member 18	424	44846	9.66	10	Apical cell membrane	Lung cancer;Rhabdomyosarcoma, embryonal, 1	May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Organic cation transport;Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)	PE1	11
+NX_Q96BI3	Gamma-secretase subunit APH-1A	265	28996	7.74	7	Golgi stack membrane;Endoplasmic reticulum membrane	NA	Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12763021, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Required for normal gamma-secretase assembly (PubMed:12522139, PubMed:12471034, PubMed:12763021, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).	NA	Belongs to the APH-1 family.	Notch signaling pathway;Alzheimer's disease;EPH-ephrin mediated repulsion of cells;Amyloid fiber formation;Nuclear signaling by ERBB4;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Regulated proteolysis of p75NTR;NOTCH2 Activation and Transmission of Signal to the Nucleus;NRIF signals cell death from the nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3;NOTCH4 Activation and Transmission of Signal to the Nucleus	PE1	1
+NX_Q96BJ3	Axin interactor, dorsalization-associated protein	306	35023	6.13	0	Cytosol;Cytoskeleton	NA	Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).	NA	Belongs to the AIDA family.	NA	PE1	1
+NX_Q96BJ8	Engulfment and cell motility protein 3	720	81467	5.94	0	Cytoplasm;Cell junction;Cell membrane	NA	Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).	NA	NA	NA	PE1	16
+NX_Q96BK5	PIN2/TERF1-interacting telomerase inhibitor 1	328	37035	9.61	0	Nucleolus;Nucleoplasm;Telomere;Nucleus;Kinetochore	NA	Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.	NA	Belongs to the PINX1 family.	NA	PE1	8
+NX_Q96BM0	Interferon alpha-inducible protein 27-like protein 1	104	9549	9.7	3	Membrane	NA	Plays a role in the apoptotic process and has a pro-apoptotic activity.	NA	Belongs to the IFI6/IFI27 family.	NA	PE1	14
+NX_Q96BM1	Ankyrin repeat domain-containing protein 9	317	34295	9.59	0	NA	NA	NA	NA	NA	Neddylation	PE1	14
+NX_Q96BM9	ADP-ribosylation factor-like protein 8A	186	21416	7.63	0	Axon;Lysosome membrane;Synapse;Spindle;Late endosome membrane	NA	Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity).	NA	Belongs to the small GTPase superfamily. Arf family.	Neutrophil degranulation	PE1	1
+NX_Q96BN2	Transcriptional adapter 1	335	37382	6.92	0	Nucleoplasm;Cytosol;Focal adhesion;Nucleus	NA	Probably involved in transcriptional regulation.	NA	Belongs to the TADA1 family.	HATs acetylate histones	PE1	1
+NX_Q96BN6	Protein FAM149B1	582	64618	6.3	0	Nucleoplasm	NA	NA	NA	Belongs to the FAM149 family.	NA	PE1	10
+NX_Q96BN8	Ubiquitin thioesterase otulin	352	40263	5.35	0	Cytoplasm;Mitochondrion;Cell membrane	Autoinflammation, panniculitis, and dermatosis syndrome	Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:26997266, PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327, PubMed:28919039). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling (PubMed:23806334).	Acetylated.;Ubiquitinated.;Phosphorylated (PubMed:23746843, PubMed:24726323, PubMed:24726327). Phosphorylation at Tyr-56 prevents interaction with RNF31; dephosphorylation promotes interaction with RNF31 and the LUBAC complex (PubMed:24726323, PubMed:24726327).	Belongs to the peptidase C65 family. Otulin subfamily.	Regulation of TNFR1 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	5
+NX_Q96BP2	Coiled-coil-helix-coiled-coil-helix domain-containing protein 1	118	13475	10.24	0	Nucleoplasm;Nucleus;Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mS37 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	10
+NX_Q96BP3	Peptidylprolyl isomerase domain and WD repeat-containing protein 1	646	73575	6.7	0	Nucleus	NA	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638).	NA	Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.	mRNA Splicing - Major Pathway	PE1	5
+NX_Q96BQ1	Protein FAM3D	224	24963	9.42	0	Secreted	NA	NA	NA	Belongs to the FAM3 family.	NA	PE1	3
+NX_Q96BQ3	Tripartite motif-containing protein 43	446	52265	8.24	0	NA	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE1	2
+NX_Q96BQ5	Coiled-coil domain-containing protein 127	260	30834	9.26	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	5
+NX_Q96BR1	Serine/threonine-protein kinase Sgk3	496	57108	6.45	0	Nucleoplasm;Early endosome;Recycling endosome;Cytoplasmic vesicle	NA	Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.	Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Stimuli-sensing channels	PE1	8
+NX_Q96BR5	Cytochrome c oxidase assembly factor 7	231	25709	5.66	0	Nucleoplasm;Mitochondrion intermembrane space;Mitochondrion	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 3	Required for assembly of mitochondrial respiratory chain complex I and complex IV.	NA	Belongs to the hcp beta-lactamase family.	NA	PE1	1
+NX_Q96BR6	Zinc finger protein 669	464	52597	9.06	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q96BR9	Zinc finger and BTB domain-containing protein 8A	441	50141	6.81	0	Nucleus speckle;Focal adhesion;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	1
+NX_Q96BS2	Calcineurin B homologous protein 3	214	24750	4.84	0	Cytoplasm;Cell membrane;Membrane;Nucleoplasm;Lamellipodium;Ruffle membrane;Cytosol;Nucleus	NA	Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.	NA	Belongs to the calcineurin regulatory subunit family. CHP subfamily.	NA	PE1	12
+NX_Q96BT1	Putative uncharacterized protein C3orf49	292	33461	10.19	0	NA	NA	NA	NA	NA	NA	PE2	3
+NX_Q96BT3	Centromere protein T	561	60423	6.14	0	Kinetochore;Centromere;Nucleus	NA	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.	Dynamically phosphorylated at Ser-47 and probably also other sites during the cell cycle. Phosphorylated at Ser-47 during G2 phase, metaphase and anaphase, but not during telophase or G1 phase.	Belongs to the CENP-T/CNN1 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	16
+NX_Q96BT7	Alkylated DNA repair protein alkB homolog 8	664	75208	8.21	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).	NA	Belongs to the alkB family.	tRNA modification in the nucleus and cytosol	PE1	11
+NX_Q96BU1	S100P-binding protein	408	45582	5.02	0	Nucleus speckle;Nucleus	NA	NA	NA	NA	NA	PE1	1
+NX_Q96BV0	Zinc finger protein 775	537	59752	10.23	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q96BW1	Uracil phosphoribosyltransferase homolog	309	33786	5.71	0	Nucleoplasm;Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the UPRTase family.	Pyrimidine metabolism;Metabolic pathways	PE1	X
+NX_Q96BW5	Phosphotriesterase-related protein	349	39018	6.07	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.	NA	PE1	10
+NX_Q96BW9	Phosphatidate cytidylyltransferase, mitochondrial	452	51067	8.23	0	Cytosol;Mitochondrion inner membrane	NA	Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.	NA	Belongs to the TAM41 family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.	PE1	3
+NX_Q96BX8	MOB kinase activator 3A	217	25464	8.81	0	NA	NA	May regulate the activity of kinases.	NA	Belongs to the MOB1/phocein family.	NA	PE1	19
+NX_Q96BY2	Modulator of apoptosis 1	351	39513	5.21	0	Cytoplasm;Nucleoplasm;Cell junction	NA	Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.	Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39.	Belongs to the PNMA family.	NA	PE1	14
+NX_Q96BY6	Dedicator of cytokinesis protein 10	2186	249531	6.72	0	Cytoplasm;Dendritic spine;Nucleoplasm;Cytosol;Nucleus	NA	Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.	NA	Belongs to the DOCK family.	Factors involved in megakaryocyte development and platelet production	PE1	2
+NX_Q96BY7	Autophagy-related protein 2 homolog B	2078	232763	5.49	0	Nucleoplasm;Preautophagosomal structure membrane;Lipid droplet	NA	Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.	NA	Belongs to the ATG2 family.	NA	PE1	14
+NX_Q96BY9	Store-operated calcium entry-associated regulatory factor	339	36975	7.5	1	Endoplasmic reticulum;Cytoplasm;Endoplasmic reticulum membrane	NA	Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.	NA	Belongs to the SARAF family.	NA	PE1	8
+NX_Q96BZ4	Phospholipase D4	506	55626	8.61	1	Membrane	NA	NA	NA	Belongs to the phospholipase D family.	Role of phospholipids in phagocytosis;Synthesis of IP3 and IP4 in the cytosol;Synthesis of PG	PE1	14
+NX_Q96BZ8	Leukocyte receptor cluster member 1	264	30529	9.68	0	Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	19
+NX_Q96BZ9	TBC1 domain family member 20	403	45855	6.37	2	Membrane	Warburg micro syndrome 4	GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.	NA	NA	COPII-mediated vesicle transport;TBC/RABGAPs	PE1	20
+NX_Q96C00	Zinc finger and BTB domain-containing protein 9	473	50602	6.29	0	Nucleoplasm;Nucleus;Nucleus membrane	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	6
+NX_Q96C01	Protein FAM136A	138	15641	7.56	0	Mitochondrion	NA	NA	NA	Belongs to the FAM136 family.	NA	PE1	2
+NX_Q96C03	Mitochondrial dynamics protein MID49	454	49269	5.01	1	Mitochondrion outer membrane	NA	Mitochondrial outer membrane protein which regulates mitochondrial organization (PubMed:29361167). It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity.	NA	Belongs to the MID49/MID51 family.	NA	PE1	17
+NX_Q96C10	Probable ATP-dependent RNA helicase DHX58	678	76613	6.98	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol	NA	Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.	NA	Belongs to the helicase family. RLR subfamily.	RIG-I-like receptor signaling pathway;DDX58/IFIH1-mediated induction of interferon-alpha/beta	PE1	17
+NX_Q96C11	FGGY carbohydrate kinase domain-containing protein	551	59993	5.9	0	Cytoplasm;Nucleoplasm;Nucleus	Amyotrophic lateral sclerosis	NA	NA	Belongs to the FGGY kinase family.	NA	PE1	1
+NX_Q96C12	Armadillo repeat-containing protein 5	935	97682	6.75	0	Nucleoplasm;Cytosol;Cytoplasm;Focal adhesion	ACTH-independent macronodular adrenal hyperplasia 2	Involved in fetal development, T-cell function and adrenal gland growth homeostasis (By similarity). Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429).	NA	NA	NA	PE1	16
+NX_Q96C19	EF-hand domain-containing protein D2	240	26697	5.15	0	Cytosol;Membrane raft	NA	May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.	NA	NA	NA	PE1	1
+NX_Q96C23	Aldose 1-epimerase	342	37766	6.18	0	Cytoplasm;Nucleoplasm	NA	Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).	NA	Belongs to the aldose epimerase family.	Carbohydrate metabolism; hexose metabolism.;Glycolysis / Gluconeogenesis	PE1	2
+NX_Q96C24	Synaptotagmin-like protein 4	671	76024	9.1	0	Membrane;Cytoplasmic vesicle;Secretory vesicle membrane;Cell membrane	NA	Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).	NA	NA	Platelet degranulation	PE1	X
+NX_Q96C28	Zinc finger protein 707	371	43088	9.73	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	8
+NX_Q96C34	RUN domain-containing protein 1	613	67643	5.84	0	Cytosol;Nucleus speckle	NA	May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.	NA	NA	NA	PE1	17
+NX_Q96C36	Pyrroline-5-carboxylate reductase 2	320	33637	7.66	0	Cytoplasm;Mitochondrion	Leukodystrophy, hypomyelinating, 10	Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492).	NA	Belongs to the pyrroline-5-carboxylate reductase family.	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.;Arginine and proline metabolism;Metabolic pathways;Glutamate and glutamine metabolism	PE1	1
+NX_Q96C45	Serine/threonine-protein kinase ULK4	1275	142442	5.9	0	Nucleoplasm;Cytosol;Mitochondrion	NA	May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.	NA	PE1	3
+NX_Q96C55	Zinc finger protein 524	264	28709	9.07	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q96C57	Protein CUSTOS	262	28171	9.44	0	Golgi apparatus;Nucleolus;Nucleus envelope;Nucleus	NA	Plays a role in the regulation of Wnt signaling pathway during early development.	NA	Belongs to the CUSTOS family.	NA	PE1	12
+NX_Q96C74	Ropporin-1-like protein	230	26107	7.62	0	Cilium;Flagellum	NA	Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.	Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.	Belongs to the ropporin family.	NA	PE1	5
+NX_Q96C86	m7GpppX diphosphatase	337	38609	5.93	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Al-Raqad syndrome	Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.	NA	Belongs to the HIT family.	RNA degradation;mRNA decay by 3' to 5' exoribonuclease	PE1	11
+NX_Q96C90	Protein phosphatase 1 regulatory subunit 14B	147	15911	4.75	0	Cytoplasm	NA	Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).	Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) (By similarity).	Belongs to the PP1 inhibitor family.	NA	PE1	11
+NX_Q96C92	Endosome-associated-trafficking regulator 1	435	47961	5.03	0	Cytoplasm;Recycling endosome;Early endosome;Cilium basal body;Endosome;Centrosome;Midbody	NA	Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity).	Phosphorylated.	Belongs to the ENTR1 family.	NA	PE1	9
+NX_Q96CA5	Baculoviral IAP repeat-containing protein 7	298	32798	5.43	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Protects against natural killer (NK) cell killing whereas isoform 1 augments killing.;Blocks etoposide-induced apoptosis.;Blocks staurosporine-induced apoptosis.;Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9.	Autoubiquitinated and undergoes proteasome-mediated degradation.;The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect.	Belongs to the IAP family.	NA	PE1	20
+NX_Q96CB5	Putative uncharacterized protein C8orf44	159	18380	10.91	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE2	8
+NX_Q96CB8	Integrator complex subunit 12	462	48808	9.72	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).	NA	Belongs to the Integrator subunit 12 family.	RNA polymerase II transcribes snRNA genes	PE1	4
+NX_Q96CB9	5-methylcytosine rRNA methyltransferase NSUN4	384	43089	8.47	0	Mitochondrion	NA	Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	rRNA modification in the mitochondrion	PE1	1
+NX_Q96CC6	Inactive rhomboid protein 1	855	97401	8.8	7	Cytoplasmic vesicle;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.	N-glycosylated.	Belongs to the peptidase S54 family.	NA	PE1	16
+NX_Q96CD0	F-box/LRR-repeat protein 8	374	40516	6.96	0	Golgi apparatus	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	16
+NX_Q96CD2	Phosphopantothenoylcysteine decarboxylase	204	22395	5.72	0	Cytosol	NA	Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.	NA	Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.;Pantothenate and CoA biosynthesis;Metabolic pathways;Coenzyme A biosynthesis	PE1	15
+NX_Q96CE8	Transmembrane 4 L6 family member 18	201	22277	7.4	4	Membrane;Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the L6 tetraspanin family.	NA	PE2	3
+NX_Q96CF2	Charged multivesicular body protein 4c	233	26411	5.83	0	Cytosol;Late endosome membrane;Midbody ring	NA	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission (PubMed:22422861, PubMed:24814515). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).	Phosphorylated at Ser-210 by AURKB during cytokinesis: together with ZFYVE19/ANCHR, phosphorylated CHMP4C retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis.	Belongs to the SNF7 family.	Endocytosis;Macroautophagy;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	8
+NX_Q96CG3	TRAF-interacting protein with FHA domain-containing protein A	184	21445	5.04	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleolus	NA	Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (PubMed:12566447, PubMed:15492226, PubMed:26068852, PubMed:28877472, PubMed:28222186, PubMed:30111836). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (PubMed:15492226, PubMed:26068852). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of proinflammatory NF-kappa-B signaling (PubMed:30111836).	Phosphorylated at Thr-9 following detection of ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose) by ALPK1 (PubMed:30111836). Phosphorylation at Thr-9 by ALPK1 leads to the formation of an intermolecular binding between the FHA domain and phosphorylated Thr-9, promoting TIFA oligomerization and TIFA-mediated NF-kappa-B activation (PubMed:22566686, PubMed:30111836, PubMed:26389808).	Belongs to the TIFA family.	NA	PE1	4
+NX_Q96CG8	Collagen triple helix repeat-containing protein 1	243	26224	8.31	0	Nucleoplasm;Extracellular matrix	Barrett esophagus	May act as a negative regulator of collagen matrix deposition.	N-glycosylated.	NA	NA	PE1	8
+NX_Q96CH1	Probable G-protein coupled receptor 146	333	36580	8.55	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	7
+NX_Q96CJ1	ELL-associated factor 2	260	28792	5.04	0	Nucleus speckle	NA	Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.	NA	Belongs to the EAF family.	Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation	PE1	3
+NX_Q96CK0	Zinc finger protein 653	615	67235	6.53	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q96CM3	Mitochondrial RNA pseudouridine synthase RPUSD4	377	42205	9.9	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	NA	Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).	NA	Belongs to the pseudouridine synthase RluA family.	NA	PE1	11
+NX_Q96CM4	Nucleoredoxin-like protein 1	212	23943	4.72	0	Photoreceptor outer segment	NA	May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods.	NA	Belongs to the nucleoredoxin family.	NA	PE1	19
+NX_Q96CM8	Medium-chain acyl-CoA ligase ACSF2, mitochondrial	615	68125	7.5	0	Nucleoplasm;Cytosol;Mitochondrion;Cytoskeleton	NA	Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044). Has some preference toward medium-chain substrates (PubMed:17762044). Plays a role in adipocyte differentiation (PubMed:16380219).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Mitochondrial Fatty Acid Beta-Oxidation	PE1	17
+NX_Q96CN4	EVI5-like protein	794	91376	5.25	0	Nucleus	NA	Functions as a GTPase-activating protein (GAP) with a broad specificity.	NA	NA	NA	PE1	19
+NX_Q96CN5	Leucine-rich repeat-containing protein 45	670	75951	5.95	0	Nucleoplasm;Cytosol;Centrosome;Cell membrane	NA	Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.	Phosphorylated by NEK2 during misosis, phosphorylation reduces centrosomal localization which subsequently leads to centrosome separation.	NA	NA	PE1	17
+NX_Q96CN7	Isochorismatase domain-containing protein 1	298	32237	6.96	0	Endoplasmic reticulum;Cytoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the isochorismatase family.	NA	PE1	5
+NX_Q96CN9	GRIP and coiled-coil domain-containing protein 1	775	87811	5.35	0	Golgi apparatus;Cytoplasm;Cell membrane;Golgi apparatus membrane;Cytosol	NA	Probably involved in maintaining Golgi structure.	NA	NA	Retrograde transport at the Trans-Golgi-Network	PE1	7
+NX_Q96CP2	FLYWCH family member 2	140	14564	8.6	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	16
+NX_Q96CP6	Protein Aster-A	724	80680	6.29	1	Cytosol;Autophagosome;Endoplasmic reticulum membrane;Cell membrane	NA	Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192).	NA	NA	NA	PE1	19
+NX_Q96CP7	TLC domain-containing protein 1	247	28548	9.54	4	Cytoplasm;Cell membrane	NA	Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349).	NA	NA	NA	PE1	17
+NX_Q96CQ1	Solute carrier family 25 member 36	311	34283	8.8	6	Nucleoplasm;Cytosol;Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	3
+NX_Q96CS2	HAUS augmin-like complex subunit 1	278	31863	5.41	0	Cytoplasm;Spindle pole;Centrosome;Cytosol;Spindle	NA	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.	NA	Belongs to the HAUS1 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	18
+NX_Q96CS3	FAS-associated factor 2	445	52623	5.46	0	Endoplasmic reticulum;Cytoplasm;Lipid droplet	NA	Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223).	NA	NA	Neutrophil degranulation	PE1	5
+NX_Q96CS4	Zinc finger protein 689	500	56907	9.89	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_Q96CS7	Pleckstrin homology domain-containing family B member 2	222	24736	5.15	0	Recycling endosome membrane	NA	Involved in retrograde transport of recycling endosomes.	NA	NA	NA	PE1	2
+NX_Q96CT2	Kelch-like protein 29	875	94228	6.73	0	Cytosol;Mitochondrion	NA	NA	NA	NA	NA	PE1	2
+NX_Q96CT7	Coiled-coil domain-containing protein 124	223	25835	9.54	0	Cytosol;Centrosome;Midbody;Cell membrane	NA	Required for proper progression of late cytokinetic stages.	NA	Belongs to the CCDC124 family.	NA	PE1	19
+NX_Q96CU9	FAD-dependent oxidoreductase domain-containing protein 1	486	53812	7.66	1	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 19	Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554).	NA	NA	NA	PE1	11
+NX_Q96CV9	Optineurin	577	65922	5.12	0	trans-Golgi network;Golgi apparatus;Recycling endosome;Autophagosome;Cytoplasmic vesicle;Cytosol;Perinuclear region	Amyotrophic lateral sclerosis 12;Glaucoma 1, open angle, E;Glaucoma, normal pressure	(Microbial infection) May constitute a cellular target for adenovirus E3 14.7 and Bluetongue virus protein NS3 to inhibit innate immune response.;Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.	Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection. Phosphorylation is induced by phorbol esters and decreases its half-time.	NA	Regulation of PLK1 Activity at G2/M Transition;TBC/RABGAPs	PE1	10
+NX_Q96CW1	AP-2 complex subunit mu	435	49655	9.57	0	Coated pit;Cell membrane	NA	Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity).	NA	Belongs to the adaptor complexes medium subunit family.	Endocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Huntington's disease;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Retrograde neurotrophin signalling;Recycling pathway of L1;Nef Mediated CD8 Down-regulation;Nef mediated downregulation of CD28 cell surface expression;Gap junction degradation;WNT5A-dependent internalization of FZD4;Nef Mediated CD4 Down-regulation;Formation of annular gap junctions;Trafficking of GluR2-containing AMPA receptors;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance	PE1	3
+NX_Q96CW5	Gamma-tubulin complex component 3	907	103571	8.35	0	Centrosome	NA	Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.	NA	Belongs to the TUBGCP family.	Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes	PE1	13
+NX_Q96CW6	Probable RNA polymerase II nuclear localization protein SLC7A6OS	309	35028	4.52	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Directs RNA polymerase II nuclear import.	NA	Belongs to the IWR1/SLC7A6OS family.	NA	PE1	16
+NX_Q96CW9	Netrin-G2	530	59799	6.13	0	Cell membrane;Cytoskeleton;Midbody ring	NA	Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.	N-glycosylated.	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	9
+NX_Q96CX2	BTB/POZ domain-containing protein KCTD12	325	35701	5.51	0	Mitochondrion;Presynaptic cell membrane;Postsynaptic cell membrane	NA	Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).	NA	NA	NA	PE1	13
+NX_Q96CX3	Zinc finger protein 501	271	31179	9.39	0	Endoplasmic reticulum;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q96CX6	Leucine-rich repeat-containing protein 58	371	40586	6.41	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	3
+NX_Q96D03	DNA damage-inducible transcript 4-like protein	193	21740	7.49	0	Cytoplasm;Nucleoplasm;Cell membrane;Cytoskeleton	NA	Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.	NA	Belongs to the DDIT4 family.	NA	PE1	4
+NX_Q96D05	Protein FAM241B	121	13238	11.58	1	Membrane;Nucleoplasm;Cytosol;Centrosome	NA	May play a role in lysosome homeostasis.	NA	Belongs to the FAM241 family.	NA	PE1	10
+NX_Q96D09	G-protein coupled receptor-associated sorting protein 2	838	93773	4.96	0	Nucleoplasm;Cytoplasm;Cytosol	Deafness, X-linked, 7	May play a role in regulation of a variety of G-protein coupled receptors.	NA	Belongs to the GPRASP family.	NA	PE1	X
+NX_Q96D15	Reticulocalbin-3	328	37493	4.74	0	Endoplasmic reticulum;Endoplasmic reticulum lumen;Cytoplasmic vesicle	NA	Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634).	N-glycosylated.;Degraded by PCSK6 and other endoproteases including FURIN and PCSK5.	Belongs to the CREC family.	NA	PE1	19
+NX_Q96D21	GTP-binding protein Rhes	266	30366	9.09	0	Cytosol;Cell membrane	NA	GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.	Farnesylated. Farnesylation is required for membrane targeting (By similarity).	Belongs to the small GTPase superfamily. RasD family.	NA	PE1	22
+NX_Q96D31	Calcium release-activated calcium channel protein 1	301	32668	8.45	4	Cytosol;Cell membrane	Myopathy, tubular aggregate, 2;Immunodeficiency 9	Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).	N-glycosylated.;Cys-195 is oxidated, leading to inactivate channel activity.;Ubiquitinated.	Belongs to the Orai family.	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Elevation of cytosolic Ca2+ levels;Ion homeostasis	PE1	12
+NX_Q96D42	Hepatitis A virus cellular receptor 1	364	39250	6.44	1	Membrane;Cytoplasmic vesicle	NA	May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.;(Microbial infection) Acts as a receptor for Hepatitis A virus.;(Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane.;(Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane.	NA	Belongs to the immunoglobulin superfamily. TIM family.	NA	PE1	5
+NX_Q96D46	60S ribosomal export protein NMD3	503	57603	6.76	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	NA	Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.	NA	Belongs to the NMD3 family.	Ribosome biogenesis in eukaryotes;RNA transport	PE1	3
+NX_Q96D53	Atypical kinase COQ8B, mitochondrial	544	60069	6.84	1	Mitochondrion membrane;Cytosol;Mitochondrion;Cell membrane	Nephrotic syndrome 9	Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration (PubMed:24270420).	NA	Belongs to the protein kinase superfamily. ADCK protein kinase family.	NA	PE1	19
+NX_Q96D59	E3 ubiquitin-protein ligase RNF183	192	21617	7.59	1	Endoplasmic reticulum;Lysosome membrane;cis-Golgi network membrane;Endoplasmic reticulum membrane	NA	Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).	Autoubiquitinated (in vitro).	NA	Protein modification; protein ubiquitination.	PE1	9
+NX_Q96D70	R3H domain-containing protein 4	268	30350	8.82	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	19
+NX_Q96D71	RalBP1-associated Eps domain-containing protein 1	796	86662	5.45	0	Cytoplasmic vesicle;Cytosol;Clathrin-coated pit;Cell membrane	Neurodegeneration with brain iron accumulation 7	May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.	EGF stimulates phosphorylation on Tyr-residues.	NA	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	6
+NX_Q96D96	Voltage-gated hydrogen channel 1	273	31683	6.33	4	Membrane;Cell membrane	NA	Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.	Phosphorylation may enhance channel gating.	Belongs to the hydrogen channel family.	ROS and RNS production in phagocytes;Sperm Motility And Taxes;Neutrophil degranulation	PE1	12
+NX_Q96D98	EP300-interacting inhibitor of differentiation 2B	161	16985	4.67	0	Nucleus	NA	Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.	NA	NA	NA	PE1	19
+NX_Q96DA0	Zymogen granule protein 16 homolog B	208	22739	6.74	0	Cytoplasmic vesicle;Nucleoplasm;Secreted	NA	NA	NA	Belongs to the jacalin lectin family.	NA	PE1	16
+NX_Q96DA2	Ras-related protein Rab-39B	213	24622	7.69	0	Golgi apparatus;Cytoplasmic vesicle membrane;Cell membrane	Mental retardation, X-linked 72;Waisman syndrome	Small GTPases Rab involved in autophagy (PubMed:27103069). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27103069). May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (By similarity).	NA	Belongs to the small GTPase superfamily. Rab family.	RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	X
+NX_Q96DA6	Mitochondrial import inner membrane translocase subunit TIM14	116	12499	10.1	1	Mitochondrion inner membrane	3-methylglutaconic aciduria 5	Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).	NA	Belongs to the TIM14 family.	Mitochondrial protein import	PE1	3
+NX_Q96DB2	Histone deacetylase 11	347	39183	7.17	0	Nucleus;Cell membrane	NA	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	NA	Belongs to the histone deacetylase family.	Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	PE1	3
+NX_Q96DB5	Regulator of microtubule dynamics protein 1	314	35808	8.64	0	Cytoplasm;Spindle pole;Centrosome;Spindle;Cytoskeleton	NA	NA	NA	Belongs to the RMDN family.	NA	PE1	8
+NX_Q96DB9	FXYD domain-containing ion transport regulator 5	178	19472	5.51	1	Membrane;Endoplasmic reticulum;Cell membrane	NA	Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.	Glycosylated.	Belongs to the FXYD family.	NA	PE1	19
+NX_Q96DC7	Transmembrane and coiled-coil domain-containing protein 6	493	54442	5.58	2	Membrane;Nucleoplasm;Mitochondrion	NA	NA	NA	NA	NA	PE1	5
+NX_Q96DC8	Enoyl-CoA hydratase domain-containing protein 3, mitochondrial	303	32634	8.9	0	Mitochondrion	NA	May play a role in fatty acid biosynthesis and insulin sensitivity.	NA	Belongs to the enoyl-CoA hydratase/isomerase family.	NA	PE1	10
+NX_Q96DC9	Ubiquitin thioesterase OTUB2	234	27213	5.81	0	NA	NA	Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.	NA	Belongs to the peptidase C65 family.	Ovarian tumor domain proteases	PE1	14
+NX_Q96DD0	Leucine-rich repeat-containing protein 39	335	38793	5.99	0	M line	NA	Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart.	NA	NA	NA	PE1	1
+NX_Q96DD7	Protein shisa-4	197	21522	8.21	1	Membrane	NA	NA	NA	Belongs to the shisa family.	NA	PE1	1
+NX_Q96DE0	U8 snoRNA-decapping enzyme	195	21273	6.38	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	NA	RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms (PubMed:20385596, PubMed:26121039). The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP (PubMed:20385596). Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (PubMed:20385596).	NA	Belongs to the Nudix hydrolase family. NUDT16 subfamily.	Phosphate bond hydrolysis by NUDT proteins	PE1	3
+NX_Q96DE5	Anaphase-promoting complex subunit 16	110	11667	4.91	0	Kinetochore;Cytoplasm;Cytosol;Nucleus	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	NA	Belongs to the APC16 family.	Protein modification; protein ubiquitination.;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	10
+NX_Q96DE9	Protein CXorf40B	158	17780	6.43	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_Q96DF8	Splicing factor ESS-2 homolog	476	52568	7.06	0	Nucleoplasm;Nucleus	NA	May be involved in pre-mRNA splicing.	NA	Belongs to the ESS2 family.	NA	PE1	22
+NX_Q96DG6	Carboxymethylenebutenolidase homolog	245	28048	6.71	0	Cytosol	NA	Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.	NA	Belongs to the dienelactone hydrolase family.	Metabolic pathways;Phase I - Functionalization of compounds	PE1	5
+NX_Q96DH6	RNA-binding protein Musashi homolog 2	328	35197	8.62	0	Cytoplasm;Cytosol	NA	RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).	Phosphorylated.	Belongs to the Musashi family.	mRNA surveillance pathway	PE1	17
+NX_Q96DI7	U5 small nuclear ribonucleoprotein 40 kDa protein	357	39311	8.34	0	Nucleus speckle;Nucleus	NA	Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30705154). Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome (PubMed:9774689, PubMed:16723661, PubMed:26912367).	NA	NA	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	1
+NX_Q96DL1	NXPE family member 2	559	64901	8.85	1	Membrane	NA	NA	NA	Belongs to the NXPE family.	NA	PE1	11
+NX_Q96DM1	PiggyBac transposable element-derived protein 4	585	67004	9.29	0	Nucleoplasm;Centrosome	NA	NA	NA	NA	NA	PE1	15
+NX_Q96DM3	Regulator of MON1-CCZ1 complex	657	74975	7.89	0	Nucleoplasm;Lysosome membrane;Late endosome membrane	NA	Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162).	NA	Belongs to the RMC1 family.	NA	PE1	18
+NX_Q96DN0	Endoplasmic reticulum resident protein 27	273	30480	4.57	0	Endoplasmic reticulum lumen	NA	Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates (PubMed:16940051, PubMed:23192347). Binds protein substrates via a hydrophobic pocket in the C-terminal domain (PubMed:16940051, PubMed:23192347). May play a role in the unfolded stress response (PubMed:23192347).	NA	Belongs to the protein disulfide isomerase family.	NA	PE1	12
+NX_Q96DN2	von Willebrand factor C and EGF domain-containing protein	955	99915	6.06	0	Nucleoplasm;Cytosol;Secreted;Cytoplasmic vesicle	NA	May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.	NA	NA	NA	PE1	11
+NX_Q96DN5	TBC1 domain family member 31	1066	124189	8.84	0	Centrosome	NA	NA	NA	NA	NA	PE1	8
+NX_Q96DN6	Methyl-CpG-binding domain protein 6	1003	101201	9.72	0	Nucleoplasm;Nucleus;Chromosome	NA	Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).	NA	NA	UCH proteinases	PE1	12
+NX_Q96DP5	Methionyl-tRNA formyltransferase, mitochondrial	389	43832	9.7	0	Nucleoplasm;Cytosol;Mitochondrion	Combined oxidative phosphorylation deficiency 15;Mitochondrial complex I deficiency, nuclear type 27	Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity).	NA	Belongs to the Fmt family.	One carbon pool by folate;Aminoacyl-tRNA biosynthesis;Mitochondrial translation initiation	PE1	15
+NX_Q96DR4	StAR-related lipid transfer protein 4	205	23517	5.12	0	Cell membrane	NA	Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols.	NA	NA	Pregnenolone biosynthesis	PE1	5
+NX_Q96DR5	BPI fold-containing family A member 2	249	27011	5.35	0	Secreted	NA	Has strong antibacterial activity against P. Aeruginosa.	NA	Belongs to the BPI/LBP/Plunc superfamily. Plunc family.	Antimicrobial peptides	PE1	20
+NX_Q96DR7	Rho guanine nucleotide exchange factor 26	871	97346	9.07	0	Ruffle;Nucleoplasm;Cytosol;Cell membrane	NA	Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.	NA	NA	Bacterial invasion of epithelial cells;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	3
+NX_Q96DR8	Mucin-like protein 1	90	9039	4.41	0	Membrane;Secreted	NA	May play a role as marker for the diagnosis of metastatic breast cancer.	O-glycosylated.	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	12
+NX_Q96DS6	Membrane-spanning 4-domains subfamily A member 6E	147	15909	8.48	2	Membrane	NA	May be involved in signal transduction as a component of a multimeric receptor complex.	NA	Belongs to the MS4A family.	NA	PE2	11
+NX_Q96DT0	Galectin-12	336	37542	9.3	0	Nucleus	NA	Binds lactose. May participate in the apoptosis of adipocytes.	NA	NA	NA	PE1	11
+NX_Q96DT5	Dynein heavy chain 11, axonemal	4516	520369	6.03	0	Cilium axoneme	Ciliary dyskinesia, primary, 7	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.	NA	Belongs to the dynein heavy chain family.	NA	PE1	7
+NX_Q96DT6	Cysteine protease ATG4C	458	52497	5.65	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.	NA	Belongs to the peptidase C54 family.	Regulation of autophagy;Macroautophagy	PE1	1
+NX_Q96DT7	Zinc finger and BTB domain-containing protein 10	871	94894	5.05	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	8
+NX_Q96DU3	SLAM family member 6	332	37345	6.32	1	Cytosol;Cell membrane	NA	Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity).	Phosphorylation in NK cells upon engagment by SLAMF6-expressing target cells is leading to receptor activation.	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	1
+NX_Q96DU7	Inositol-trisphosphate 3-kinase C	683	75207	5.03	0	Cytoplasm;Nucleus speckle;Nucleus	Kawasaki disease	Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.	NA	Belongs to the inositol phosphokinase (IPK) family.	Synthesis of IP3 and IP4 in the cytosol	PE1	19
+NX_Q96DU9	Polyadenylate-binding protein 5	382	43331	9.55	0	Cytoplasm;Mitochondrion matrix	NA	Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).	NA	NA	RNA transport;mRNA surveillance pathway;RNA degradation	PE1	X
+NX_Q96DV4	39S ribosomal protein L38, mitochondrial	380	44597	7.19	0	Mitochondrion	NA	NA	NA	Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	17
+NX_Q96DW6	Mitochondrial glycine transporter	304	33566	9.57	6	Mitochondrion inner membrane	Anemia, sideroblastic, 2, pyridoxine-refractory	Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.	NA	PE1	3
+NX_Q96DX4	RING finger and SPRY domain-containing protein 1	576	64180	5.35	0	Secreted	Spondyloepimetaphyseal dysplasia, Faden-Alkuraya type	NA	NA	NA	NA	PE1	16
+NX_Q96DX5	Ankyrin repeat and SOCS box protein 9	294	31858	6.48	0	Mitochondrion	NA	Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	X
+NX_Q96DX7	Tripartite motif-containing protein 44	344	38472	4.16	0	Cytoplasmic vesicle;Cell membrane	Aniridia 3	May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807).	NA	NA	NA	PE1	11
+NX_Q96DX8	Receptor-transporting protein 4	246	27863	8.56	1	Membrane;Nucleoplasm	NA	Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).	NA	Belongs to the TMEM7 family.	Olfactory Signaling Pathway	PE1	3
+NX_Q96DY2	Dynein regulatory complex protein 10	449	52359	9.26	0	Nucleoplasm;Flagellum axoneme	NA	Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.	NA	Belongs to the DRC10 family.	NA	PE1	12
+NX_Q96DY7	Mdm2-binding protein	904	102193	7.91	0	Nucleoplasm;Nucleus	NA	Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.	NA	Belongs to the MTBP family.	NA	PE1	8
+NX_Q96DZ1	Endoplasmic reticulum lectin 1	483	54858	5.88	0	Endoplasmic reticulum lumen	NA	Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.	Are N-glycosylated.	NA	Protein processing in endoplasmic reticulum;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis	PE1	2
+NX_Q96DZ5	CAP-Gly domain-containing linker protein 3	547	59560	7.93	0	Golgi apparatus;Cytoplasm;Golgi stack;Cell membrane	NA	Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.	Palmitoylation by ZDHHC17 regulates association with the plasma membrane.	NA	Regulation of TNFR1 signaling	PE1	19
+NX_Q96DZ7	Transmembrane 4 L6 family member 19	209	22433	8.87	4	Membrane	NA	NA	NA	Belongs to the L6 tetraspanin family.	NA	PE2	3
+NX_Q96DZ9	CKLF-like MARVEL transmembrane domain-containing protein 5	223	24653	6.13	4	Golgi apparatus;Cytoplasmic vesicle;Membrane	NA	NA	NA	Belongs to the chemokine-like factor family.	NA	PE1	14
+NX_Q96E09	Protein FAM122A	287	30529	6.32	0	Nucleoplasm;Nucleus	NA	Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA).	NA	Belongs to the FAM122 family.	NA	PE1	9
+NX_Q96E11	Ribosome-recycling factor, mitochondrial	262	29277	9.8	0	Mitochondrion;Cytoskeleton	NA	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).	NA	Belongs to the RRF family.	Mitochondrial translation termination	PE1	9
+NX_Q96E14	RecQ-mediated genome instability protein 2	147	15865	7.76	0	Cytosol;Nucleus speckle;Nucleus	NA	Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.	Phosphorylated during mitosis.	Belongs to the RMI2 family.	Fanconi anemia pathway;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	16
+NX_Q96E16	Small integral membrane protein 19	107	12439	5.37	1	Membrane;Nucleus speckle	NA	NA	NA	Belongs to the SMIM19 family.	NA	PE1	8
+NX_Q96E17	Ras-related protein Rab-3C	227	25952	5.09	0	Cytosol;Cell membrane	NA	Protein transport. Probably involved in vesicular traffic (By similarity).	Phosphorylation of Thr-94 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2.	Belongs to the small GTPase superfamily. Rab family.	RAB geranylgeranylation	PE1	5
+NX_Q96E22	Dehydrodolichyl diphosphate synthase complex subunit NUS1	293	33224	8.81	3	Cytoplasmic vesicle;Endoplasmic reticulum membrane;Cell membrane	Congenital disorder of glycosylation 1AA;Mental retardation, autosomal dominant 55, with seizures	With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. Condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300).	NA	Belongs to the UPP synthase family.	Lipid metabolism.;Protein modification; protein glycosylation.;Synthesis of Dolichyl-phosphate;Defective DHDDS causes retinitis pigmentosa 59	PE1	6
+NX_Q96E29	Transcription termination factor 3, mitochondrial	417	47971	8.6	0	Nucleoplasm;Mitochondrion	NA	Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity).	NA	Belongs to the mTERF family.	Pink/Parkin Mediated Mitophagy	PE1	8
+NX_Q96E35	Zinc finger MYND domain-containing protein 19	227	26433	6.4	0	Cytoplasmic vesicle;Golgi apparatus;Cytoplasm;Cell membrane	NA	May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.	NA	NA	NA	PE1	9
+NX_Q96E39	RNA binding motif protein, X-linked-like-1	390	42142	9.9	0	Nucleus	NA	RNA-binding protein which may be involved in pre-mRNA splicing.	NA	NA	Spliceosome	PE1	1
+NX_Q96E40	Sperm acrosome-associated protein 9	222	25166	9.3	0	Cytoplasm;Mitochondrion;Cilium basal body;Flagellum;Nucleus;Acrosome	NA	NA	NA	NA	NA	PE1	9
+NX_Q96E52	Metalloendopeptidase OMA1, mitochondrial	524	60120	9.36	2	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.	In normal conditions, cleaved into an inactive 40 kDa form. Following CCCP treatment that induces loss of mitochondrial membrane potential, the 40 kDa form is reduced in favor of an active 60 kDa form.	Belongs to the peptidase M48 family.	Regulation of Apoptosis	PE1	1
+NX_Q96E66	Leucine-rich repeat-containing protein 51	192	22206	9.38	0	Cytoplasm;Cytoskeleton	NA	NA	NA	NA	NA	PE1	11
+NX_Q96E93	Killer cell lectin-like receptor subfamily G member 1	195	21831	5.27	1	Cytoplasmic vesicle;Cell membrane	NA	Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	12
+NX_Q96EA4	Protein Spindly	605	70172	5.41	0	Kinetochore;Spindle pole;Centrosome;Cytosol;Nucleus	NA	Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).	NA	Belongs to the Spindly family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	5
+NX_Q96EB1	Elongator complex protein 4	424	46588	8.75	0	Cytoplasm;Nucleoplasm;Nucleus	Aniridia 2	Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576, PubMed:16713582). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244).	NA	Belongs to the ELP4 family.	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.;HATs acetylate histones	PE1	11
+NX_Q96EB6	NAD-dependent protein deacetylase sirtuin-1	747	81681	4.55	0	Cytoplasm;Mitochondrion;Nucleoplasm;PML body;Cytosol;Nucleus	NA	Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect.;SirtT1 75 kDa fragment: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly.;Regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop.;NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:24415752, PubMed:24824780). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:15152190, PubMed:14980222, PubMed:14976264). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of HIST1H1E (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14980222, PubMed:14976264, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17620057, PubMed:17283066, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteosomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism (PubMed:20817729). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletel muscle under low-glucose conditions and is involved in glucose homeostasis. Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:17334224, PubMed:16998810, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, repress selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including ARNTL/BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates ARNTL/BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteosome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity).;(Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection.	Proteolytically cleaved by cathepsin B upon TNF-alpha treatment to yield catalytic inactive but stable SirtT1 75 kDa fragment (75SirT1).;S-nitrosylated by GAPDH, leading to inhibit the NAD-dependent protein deacetylase activity.;Methylated on multiple lysine residues; methylation is enhanced after DNA damage and is dispensable for deacetylase activity toward p53/TP53.;Phosphorylated. Phosphorylated by STK4/MST1, resulting in inhibition of SIRT1-mediated p53/TP53 deacetylation. Phosphorylation by MAPK8/JNK1 at Ser-27, Ser-47, and Thr-530 leads to increased nuclear localization and enzymatic activity. Phosphorylation at Thr-530 by DYRK1A and DYRK3 activates deacetylase activity and promotes cell survival. Phosphorylation by mammalian target of rapamycin complex 1 (mTORC1) at Ser-47 inhibits deacetylation activity. Phosphorylated by CaMK2, leading to increased p53/TP53 and NF-kappa-B p65/RELA deacetylation activity (By similarity). Phosphorylation at Ser-27 implicating MAPK9 is linked to protein stability. There is some ambiguity for some phosphosites: Ser-159/Ser-162 and Thr-544/Ser-545.;SIRT1 is phosphorylated by DYRK2;SIRT1 is phosphorylated by STK4	Belongs to the sirtuin family. Class I subfamily.	Regulation of HSF1-mediated heat shock response;SIRT1 negatively regulates rRNA expression;Circadian Clock;Regulation of FOXO transcriptional activity by acetylation	PE1	10
+NX_Q96EC8	Protein YIPF6	236	26256	5.46	5	Cytoplasmic vesicle;Endoplasmic reticulum;Golgi apparatus membrane	NA	May be required for stable YIPF1 and YIPF2 protein expression.	NA	Belongs to the YIP1 family.	Golgi Associated Vesicle Biogenesis	PE1	X
+NX_Q96ED9	Protein Hook homolog 2	719	83207	5.36	0	Cytoplasm;Centrosome;Cytoplasmic vesicle;Cytosol;Cytoskeleton	NA	Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.	NA	Belongs to the hook family.	NA	PE1	19
+NX_Q96EE3	Nucleoporin SEH1	360	39649	8.34	0	Lysosome membrane;Kinetochore;Nuclear pore complex	NA	Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.;As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).	NA	Belongs to the WD repeat SEC13 family.	RNA transport;Separation of Sister Chromatids;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	18
+NX_Q96EE4	Coiled-coil domain-containing protein 126	140	15668	9.87	0	Nucleoplasm;Secreted	NA	NA	NA	NA	NA	PE1	7
+NX_Q96EF0	Myotubularin-related protein 8	704	78919	6.2	0	Nucleus envelope	NA	Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:22647598, PubMed:26143924). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:22647598, PubMed:26143924). In complex with MTMR9, negatively regulates autophagy (PubMed:22647598).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Synthesis of PIPs at the plasma membrane	PE1	X
+NX_Q96EF6	F-box only protein 17	278	31479	8.46	0	NA	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	19
+NX_Q96EF9	Zinc fingers and homeoboxes protein 1, isoform 2	292	33285	6.61	0	NA	NA	NA	NA	NA	NA	PE2	8
+NX_Q96EG1	Arylsulfatase G	525	57061	6.16	0	Lysosome	Usher syndrome 4	Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate.	N-glycosylated.;Glycosylated.;The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.	Belongs to the sulfatase family.	Lysosome;Glycosphingolipid metabolism;The activation of arylsulfatases	PE1	17
+NX_Q96EG3	Zinc finger protein 837	531	58078	9.52	0	Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q96EH3	Mitochondrial assembly of ribosomal large subunit protein 1	234	26170	5.32	0	Mitochondrion matrix;Mitochondrion	NA	Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable).	NA	Belongs to the Iojap/RsfS family.	NA	PE1	7
+NX_Q96EH5	60S ribosomal protein L39-like	51	6293	12.41	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eL39 family.	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	3
+NX_Q96EH8	E3 ubiquitin-protein ligase NEURL3	262	28789	8.36	0	NA	NA	E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation.	NA	NA	Protein modification; protein ubiquitination.	PE2	2
+NX_Q96EI5	Transcription elongation factor A protein-like 4	215	24647	5.16	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the TFS-II family. TFA subfamily.	NA	PE1	X
+NX_Q96EK2	PHD finger protein 21B	531	57455	9.43	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	22
+NX_Q96EK4	THAP domain-containing protein 11	314	34455	9.18	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).	NA	Belongs to the THAP11 family.	NA	PE1	16
+NX_Q96EK5	KIF-binding protein	621	71814	5.34	0	Cytoskeleton	Goldberg-Shprintzen syndrome	Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.	NA	Belongs to the KIF-binding protein family.	NA	PE1	10
+NX_Q96EK6	Glucosamine 6-phosphate N-acetyltransferase	184	20749	8.17	0	Endosome membrane;Golgi apparatus membrane	NA	NA	NA	Belongs to the acetyltransferase family. GNA1 subfamily.	Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.;Amino sugar and nucleotide sugar metabolism;Synthesis of UDP-N-acetyl-glucosamine	PE1	14
+NX_Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	910	103783	5.49	0	Nucleoplasm;Cytosol;Nucleus	NA	Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity).	NA	Belongs to the constitutive coactivator of PPAR-gamma family.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	6
+NX_Q96EK9	Protein KTI12 homolog	354	38616	6.47	0	Cytosol;Nucleus speckle	NA	NA	NA	Belongs to the KTI12 family.	NA	PE1	1
+NX_Q96EL1	PAK4-inhibitor INKA1	287	31574	5.2	0	Cytoplasmic vesicle;Nucleoplasm;Cytoplasm;Nucleus	NA	Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847).	NA	Belongs to the INKA family.	NA	PE1	3
+NX_Q96EL2	28S ribosomal protein S24, mitochondrial	167	19015	9.48	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uS3 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	7
+NX_Q96EL3	39S ribosomal protein L53, mitochondrial	112	12107	9.05	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL53 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	2
+NX_Q96EM0	Trans-3-hydroxy-L-proline dehydratase	354	38138	6.2	0	Cytoplasmic vesicle	NA	Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.	NA	Belongs to the proline racemase family.	NA	PE1	14
+NX_Q96EN8	Molybdenum cofactor sulfurase	888	98120	6.23	0	Cytosol;Mitochondrion	Xanthinuria 2	Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime.	NA	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.	Molybdenum cofactor biosynthesis	PE1	18
+NX_Q96EN9	Required for excision 1-B domain-containing protein	201	22599	6.47	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	19
+NX_Q96EP0	E3 ubiquitin-protein ligase RNF31	1072	119652	6.14	0	Cytoplasm;Cytosol	NA	E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:23708998).	Autoubiquitinated (PubMed:24726323). Interaction with OTULIN is required to suppress formation of 'Met-1'-linked polyubiquitin chains and prevent subsequent inactivation of the LUBAC complex (PubMed:24726323).;Cleaved by caspase during apoptosis.	Belongs to the RBR family.	Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway	PE1	14
+NX_Q96EP1	E3 ubiquitin-protein ligase CHFR	664	73386	5.71	0	Nucleus;PML body;Cytoskeleton	NA	E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.	Phosphorylated by PKB. Phosphorylation may affect its E3 ligase activity.;Poly-ADP-ribosylated. In addition to binding non covalently poly(ADP-ribose) via its PBZ-type zinc finger, the protein is also covalently poly-ADP-ribosylated by PARP1.;Autoubiquitinated; may regulate its cellular level.	Belongs to the CHFR family.	Protein modification; protein ubiquitination.	PE1	12
+NX_Q96EP5	DAZ-associated protein 1	407	43383	8.73	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	RNA-binding protein, which may be required during spermatogenesis.	Acetylation at Lys-150 is predominantly observed in the nuclear fraction, and may regulate nucleocytoplasmic transport.	NA	mRNA surveillance pathway	PE1	19
+NX_Q96EP9	Sodium/bile acid cotransporter 4	437	46504	5.09	7	Cell membrane	NA	Transporter for bile acids.	Activated following N-terminal proteolytic cleavage by thrombin and/or proteases.	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.	NA	PE1	4
+NX_Q96EQ0	Small glutamine-rich tetratricopeptide repeat-containing protein beta	304	33429	4.8	0	Nucleoplasm	NA	Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.	NA	Belongs to the SGT family.	NA	PE1	5
+NX_Q96EQ8	E3 ubiquitin-protein ligase RNF125	232	26454	6.74	0	Golgi apparatus;Nucleolus;Golgi apparatus membrane	Tenorio syndrome	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525).	Autoubiquitinated, leading to its subsequent proteasomal degradation.	NA	Protein modification; protein ubiquitination.;RIG-I-like receptor signaling pathway;Negative regulators of DDX58/IFIH1 signaling	PE1	18
+NX_Q96ER3	Protein SAAL1	474	53558	4.38	0	Nucleoplasm;Nucleus	NA	Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.	NA	Belongs to the SAAL1 family.	NA	PE1	11
+NX_Q96ER9	Coiled-coil domain-containing protein 51	411	45811	8.3	2	Membrane;Nucleoplasm;Mitochondrion;Centrosome	NA	NA	NA	NA	NA	PE1	3
+NX_Q96ES6	Major facilitator superfamily domain-containing protein 3	412	42696	9.34	12	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE1	8
+NX_Q96ES7	SAGA-associated factor 29	293	33238	8.2	0	Nucleoplasm;Nucleolus;Nucleus	NA	Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).	NA	Belongs to the SGF29 family.	HATs acetylate histones	PE1	16
+NX_Q96ET8	Golgi apparatus membrane protein TVP23 homolog C	276	31105	9.47	2	Membrane;Cell membrane	NA	NA	NA	Belongs to the TVP23 family.	NA	PE1	17
+NX_Q96EU6	Ribosomal RNA processing protein 36 homolog	259	29823	10.17	0	Nucleoplasm;Nucleolus	NA	Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.	NA	Belongs to the RRP36 family.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	6
+NX_Q96EU7	C1GALT1-specific chaperone 1	318	36382	6.36	1	Membrane;Cytosol	Tn polyagglutination syndrome	Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).	NA	Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.	Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins;Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	PE1	X
+NX_Q96EV2	RNA-binding protein 33	1170	129986	6.45	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	7
+NX_Q96EV8	Dysbindin	351	39493	4.59	0	Cytoplasm;Endosome membrane;Postsynaptic cell membrane;Endoplasmic reticulum;Cytoplasmic vesicle membrane;Synaptic vesicle membrane;Postsynaptic density;Nucleus;Melanosome membrane;Midbody;Cytoskeleton	Hermansky-Pudlak syndrome 7	Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.	Ubiquitinated by TRIM32. Ubiquitination leads to DTNBP1 degradation.;Isoforms 1 and 2 highly phosphorylated by PRKDC in vitro.;Only weakly phosphorylated by PRKDC in vitro.	Belongs to the dysbindin family.	Golgi Associated Vesicle Biogenesis	PE1	6
+NX_Q96EW2	HSPB1-associated protein 1	488	55167	5.38	0	Cytoplasm;Mitochondrion	NA	May play a role in cellular stress response.	NA	NA	NA	PE1	3
+NX_Q96EX1	Small integral membrane protein 12	92	10799	8.01	1	Membrane;Mitochondrion	NA	NA	NA	Belongs to the SMIM12 family.	NA	PE1	1
+NX_Q96EX2	RING finger and transmembrane domain-containing protein 2	444	48965	8.08	4	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	12
+NX_Q96EX3	WD repeat-containing protein 34	536	57801	6.16	0	Cytoplasm;Cytosol;Cilium axoneme;Cilium basal body	Short-rib thoracic dysplasia 11 with or without polydactyly	Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.	NA	NA	Intraflagellar transport	PE1	9
+NX_Q96EY1	DnaJ homolog subfamily A member 3, mitochondrial	480	52489	9.37	0	Mitochondrion;Postsynaptic cell membrane;Mitochondrion matrix;Cytoplasmic vesicle;Cytosol	NA	Increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity.;Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation.;May play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.	Tyrosine phosphorylated.	NA	NA	PE1	16
+NX_Q96EY4	Translation machinery-associated protein 16	203	23864	9.33	0	Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the UPF0534 family.	NA	PE1	4
+NX_Q96EY5	Multivesicular body subunit 12A	273	28783	9.1	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Endosome;Centrosome;Nucleus;Late endosome membrane	NA	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.	Phosphorylated on Tyr-204 upon EGF stimulation. Phosphorylation is required for interaction with CD2AP and CIN85/SH3KBP1.	Belongs to the MVB12 family.	Endocytosis;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	19
+NX_Q96EY7	Pentatricopeptide repeat domain-containing protein 3, mitochondrial	689	78550	6	0	Mitochondrion	NA	Mitochondrial RNA-binding protein that has a role in mitochondrial translation.	NA	Belongs to the mitochondrion-specific ribosomal protein mS39 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	2
+NX_Q96EY8	Corrinoid adenosyltransferase	250	27388	8.86	0	Mitochondrion	Methylmalonic aciduria type cblB	Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA.	NA	Belongs to the Cob(I)alamin adenosyltransferase family.	Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.;Porphyrin and chlorophyll metabolism;Metabolic pathways;Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective MMAB causes methylmalonic aciduria type cblB	PE1	12
+NX_Q96EY9	Probable inactive tRNA-specific adenosine deaminase-like protein 3	351	38071	8.06	0	Nucleoplasm	Mental retardation, autosomal recessive 36	NA	NA	Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.	tRNA modification in the nucleus and cytosol	PE1	19
+NX_Q96EZ4	Myeloma-overexpressed gene protein	313	33556	9.21	0	Nucleoplasm;Cytoplasm;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE2	11
+NX_Q96EZ8	Microspherule protein 1	462	51803	9.41	0	Nucleolus;Cytoplasm;Nucleoplasm;Nucleus	NA	Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).	NA	NA	Herpes simplex infection;HATs acetylate histones;DNA Damage Recognition in GG-NER;UCH proteinases	PE1	12
+NX_Q96F05	Uncharacterized protein C11orf24	449	46101	5.59	1	Cytoplasmic vesicle;Nucleoplasm;trans-Golgi network membrane;Cell membrane	NA	NA	NA	NA	NA	PE1	11
+NX_Q96F07	Cytoplasmic FMR1-interacting protein 2	1278	148399	7.03	0	Cytoplasm;Cell membrane;Synaptosome;Endoplasmic reticulum;Cytosol;Perinuclear region;Nucleus	Epileptic encephalopathy, early infantile, 65	Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).	NA	Belongs to the CYFIP family.	Regulation of actin cytoskeleton;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;VEGFA-VEGFR2 Pathway	PE1	5
+NX_Q96F10	Diamine acetyltransferase 2	170	19155	5.77	0	Cytoplasm	NA	Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.	NA	Belongs to the acetyltransferase family.	Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1.;Arginine and proline metabolism;Metabolic pathways	PE1	17
+NX_Q96F15	GTPase IMAP family member 5	307	34846	7.6	1	Lysosome membrane;Multivesicular body membrane;Endosome membrane	NA	Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity).	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.	NA	PE1	7
+NX_Q96F24	Nuclear receptor-binding factor 2	287	32378	5.61	0	Cytoplasm;Nucleoplasm;Autophagosome;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity).;May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).	NA	NA	Nuclear Receptor transcription pathway	PE1	10
+NX_Q96F25	UDP-N-acetylglucosamine transferase subunit ALG14 homolog	216	24151	9.13	1	Nucleoplasm;Nucleolus;Endoplasmic reticulum membrane;Nucleus membrane	Myasthenic syndrome, congenital, 15	May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER.	NA	Belongs to the ALG14 family.	N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)	PE1	1
+NX_Q96F44	E3 ubiquitin-protein ligase TRIM11	468	52774	5.5	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.	NA	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	1
+NX_Q96F45	Zinc finger protein 503	646	62555	8.94	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	May function as a transcriptional repressor.	NA	Belongs to the Elbow/Noc family.	NA	PE1	10
+NX_Q96F46	Interleukin-17 receptor A	866	96122	5.06	1	Nucleoplasm;Cytosol;Secreted;Cell membrane	Immunodeficiency 51	Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).	Glycosylated.	NA	Cytokine-cytokine receptor interaction;Interleukin-17 signaling	PE1	22
+NX_Q96F63	Coiled-coil domain-containing protein 97	343	38947	4.52	0	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	19
+NX_Q96F81	Protein dispatched homolog 1	1524	170934	6.44	12	Membrane;Nucleus	NA	Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404).	NA	Belongs to the dispatched family.	NA	PE1	1
+NX_Q96F83	Uncharacterized protein CLBA1	325	35690	5.96	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	14
+NX_Q96F85	CB1 cannabinoid receptor-interacting protein 1	164	18648	7.72	0	Cytosol	NA	Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.;Does not have this effect.	NA	Belongs to the CNRIP family.	NA	PE1	2
+NX_Q96F86	Enhancer of mRNA-decapping protein 3	508	56078	6.65	0	Cytosol;P-body	Mental retardation, autosomal recessive 50	Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.	NA	Belongs to the EDC3 family.	mRNA decay by 5' to 3' exoribonuclease	PE1	15
+NX_Q96FA3	E3 ubiquitin-protein ligase pellino homolog 1	418	46286	8.33	0	NA	NA	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).	Phosphorylation by IRAK1 and IRAK4 enhances its E3 ligase activity.;Sumoylated.;PELI1 is phosphorylated by IRAK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PELI1 is phosphorylated by IRAK4 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the pellino family.	Protein modification; protein ubiquitination.;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Interleukin-1 signaling	PE1	2
+NX_Q96FA7	ZBED6 C-terminal-like protein	236	26352	7.05	0	Cytoplasmic vesicle;Nucleus membrane	NA	NA	NA	NA	NA	PE2	7
+NX_Q96FB5	Protein RRNAD1	475	52981	8.22	1	Membrane;Cytosol;Nucleolus	NA	NA	NA	Belongs to the RRNAD1 family.	NA	PE1	1
+NX_Q96FC7	Phytanoyl-CoA hydroxylase-interacting protein-like	376	42486	5.97	0	Cytoplasm;Cytosol;Mitochondrion	NA	May play a role in the development of the central system.	NA	Belongs to the PHYHIP family.	NA	PE1	10
+NX_Q96FC9	ATP-dependent DNA helicase DDX11	970	108313	7.07	0	Nucleolus;Chromosome;Midbody;Spindle pole;Centrosome;Nucleus	Warsaw breakage syndrome	(Microbial infection) Required for bovine papillomavirus type 1 regulatory protein E2 loading onto mitotic chromosomes during DNA replication for the viral genome to be maintained and segregated.;DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Plays also a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:9013641, PubMed:18499658, PubMed:22102414).	NA	Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.	XBP1(S) activates chaperone genes	PE1	12
+NX_Q96FE5	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1	620	69876	8.86	1	Cell membrane	Mental retardation, autosomal recessive 64	Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).	N-glycosylated. Contains predominantly high-mannose glycans.	NA	Axonal growth inhibition (RHOA activation)	PE1	15
+NX_Q96FE7	Phosphoinositide-3-kinase-interacting protein 1	263	28248	4.92	1	Cell membrane	NA	Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.	N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-66: dHex1Hex5HexNAc4 (major) and dHex1Hex6HexNAc5 (minor).	NA	NA	PE1	22
+NX_Q96FF7	Uncharacterized protein MISP3	219	24028	10.92	0	NA	NA	NA	NA	Belongs to the MISP family.	NA	PE1	19
+NX_Q96FF9	Sororin	252	27601	9.65	0	Cytoplasm;Nucleoplasm;Nucleus;Chromosome	NA	Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.	Ubiquitinated by the APC/C complex in G1, leading to its degradation.;Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPL by CDCA5.	Belongs to the sororin family.	Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Resolution of Sister Chromatid Cohesion	PE1	11
+NX_Q96FG2	ELMO domain-containing protein 3	381	43046	8.11	0	Mitochondrion;Nucleoplasm;Kinocilium;Stereocilium;Cytoskeleton	Deafness, autosomal recessive, 88	Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity.	NA	NA	NA	PE1	2
+NX_Q96FH0	BLOC-1-related complex subunit 8	119	13403	5.54	0	Nucleoplasm;Lysosome membrane;Cytoplasmic vesicle	NA	As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.	NA	Belongs to the BORCS8 family.	NA	PE1	19
+NX_Q96FI4	Endonuclease 8-like 1	390	43684	9.94	0	Nucleoplasm;Centrosome;Nucleus;Chromosome	NA	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.	NA	Belongs to the FPG family.	Base excision repair;APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Defective Base Excision Repair Associated with NEIL1	PE1	15
+NX_Q96FJ0	AMSH-like protease	436	49783	6.79	0	Cell membrane	NA	Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.	NA	Belongs to the peptidase M67C family.	Metalloprotease DUBs	PE1	10
+NX_Q96FJ2	Dynein light chain 2, cytoplasmic	89	10350	6.81	0	Cytoskeleton	NA	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).	NA	Belongs to the dynein light chain family.	Vasopressin-regulated water reabsorption;Separation of Sister Chromatids;Macroautophagy;MHC class II antigen presentation;Intraflagellar transport;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Activation of BMF and translocation to mitochondria;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	17
+NX_Q96FK6	WD repeat-containing protein 89	387	43215	5.72	0	Cytosol;Cytoskeleton	NA	NA	NA	NA	NA	PE1	14
+NX_Q96FL8	Multidrug and toxin extrusion protein 1	570	61922	7.53	13	Cell membrane	NA	Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.	NA	Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.	Transport of bile salts and organic acids, metal ions and amine compounds	PE1	17
+NX_Q96FL9	Polypeptide N-acetylgalactosaminyltransferase 14	552	64321	7.84	1	Golgi apparatus;Nucleoplasm;Golgi apparatus membrane	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	2
+NX_Q96FM1	Post-GPI attachment to proteins factor 3	320	36475	6.84	7	Golgi apparatus membrane;Cytosol;Endoplasmic reticulum membrane;Cell membrane	Hyperphosphatasia with mental retardation syndrome 4	Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable).	NA	Belongs to the PGAP3 family.	NA	PE1	17
+NX_Q96FN4	Copine-2	548	61190	5.71	0	Cytoplasm;Mitochondrion;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.	NA	Belongs to the copine family.	NA	PE1	16
+NX_Q96FN5	Kinesin-like protein KIF12	646	70660	9.19	0	Nucleoplasm;Cytoskeleton	NA	NA	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	9
+NX_Q96FN9	D-aminoacyl-tRNA deacylase 2	168	18660	7.71	0	Cytoplasm;Cytoplasmic vesicle	NA	Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity).	NA	Belongs to the DTD family.	NA	PE1	14
+NX_Q96FQ6	Protein S100-A16	103	11801	6.28	0	Cytoplasm;Cytosol;Nucleolus;Cell membrane	NA	Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity).	NA	Belongs to the S-100 family.	NA	PE1	1
+NX_Q96FQ7	Putative uncharacterized protein encoded by LINC00526	95	10201	7.81	0	NA	NA	NA	NA	NA	NA	PE5	18
+NX_Q96FS4	Signal-induced proliferation-associated protein 1	1042	112149	6.16	0	Golgi apparatus;Cell membrane;Endomembrane system;Nucleolus;Nucleoplasm;Perinuclear region;Nucleus	NA	GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity).	NA	NA	Leukocyte transendothelial migration;Rap1 signalling	PE1	11
+NX_Q96FT7	Acid-sensing ion channel 4	647	70105	8.04	2	Golgi apparatus;Cell membrane;Centriolar satellite;Membrane;Nucleoplasm	NA	Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity.	NA	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily.	Stimuli-sensing channels	PE1	2
+NX_Q96FT9	Intraflagellar transport protein 43 homolog	208	23529	4.62	0	Centriolar satellite;Cilium;Cytoskeleton	Cranioectodermal dysplasia 3;Short-rib thoracic dysplasia 18 with polydactyly;Retinitis pigmentosa 81	As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis (PubMed:28400947, PubMed:28973684). Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (PubMed:21378380).	NA	Belongs to the IFT43 family.	Intraflagellar transport	PE1	14
+NX_Q96FV0	Leucine-rich repeat-containing protein 46	321	35340	4.86	0	Cytosol	NA	NA	NA	NA	NA	PE1	17
+NX_Q96FV2	Secernin-2	425	46597	5.44	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	Belongs to the peptidase C69 family. Secernin subfamily.	NA	PE1	17
+NX_Q96FV3	Tetraspanin-17	270	30264	4.96	4	Membrane;Nucleoplasm	NA	Regulates ADAM10 maturation.	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	5
+NX_Q96FV9	THO complex subunit 1	657	75666	4.92	0	Nucleoplasm;Nucleus matrix;Cytoplasm;Nucleus speckle	NA	Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.;Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.	Expression is altered specifically during apoptosis and is accompanied by the appearance of novel forms with smaller apparent molecular mass.;Polyubiquitinated, leading to proteasomal degradation; probably involves NEDD4.	NA	RNA transport;Spliceosome;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	18
+NX_Q96FW1	Ubiquitin thioesterase OTUB1	271	31284	4.85	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites. Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of 'Lys-63'-linked histone H2A and H2AX marks. Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1. The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain.;Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy.;Destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin.	NA	Belongs to the peptidase C65 family.	Ub-specific processing proteases;Ovarian tumor domain proteases	PE1	11
+NX_Q96FX2	DPH3 homolog	82	9240	3.94	0	Cytoplasm;Nucleus	NA	Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.;Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).	NA	Belongs to the DPH3 family.	Protein modification; peptidyl-diphthamide biosynthesis.;Synthesis of diphthamide-EEF2	PE1	3
+NX_Q96FX7	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A	289	31382	6.89	0	Nucleus	NA	Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.	tRNA modification in the nucleus and cytosol	PE1	14
+NX_Q96FX8	p53 apoptosis effector related to PMP-22	193	21386	6.68	4	Desmosome;Cell membrane	NA	Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).	NA	Belongs to the TMEM47 family.	p53 signaling pathway;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Formation of the cornified envelope	PE1	6
+NX_Q96FZ2	Abasic site processing protein HMCES	354	40575	8.43	0	Nucleoplasm;Chromosome	NA	Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA (PubMed:30554877). The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells (By similarity). May act as an endonuclease that specifically cleaves 5hmC-containing DNA; additional experiments are however required to confirm this activity in vivo (By similarity).	Ubiquitinated; the covalent HMCES DNA-protein cross-link is ubiquitinated, leading to its degradation by the proteasome.	Belongs to the SOS response-associated peptidase family.	NA	PE1	3
+NX_Q96FZ5	CKLF-like MARVEL transmembrane domain-containing protein 7	175	18834	8.23	4	Membrane;Cell membrane	NA	NA	NA	Belongs to the chemokine-like factor family.	NA	PE1	3
+NX_Q96FZ7	Charged multivesicular body protein 6	201	23485	5.28	0	Membrane;Endomembrane system;Late endosome membrane;Endosome membrane	NA	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.	ISGylated in a CHMP5-dependent manner. Isgylation weakens its interaction with VPS4A.	Belongs to the SNF7 family.	Endocytosis;Macroautophagy;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	17
+NX_Q96G01	Protein bicaudal D homolog 1	975	110750	5.6	0	Golgi apparatus;Cytoplasmic vesicle	NA	Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.	NA	Belongs to the BicD family.	COPI-independent Golgi-to-ER retrograde traffic	PE1	12
+NX_Q96G03	Phosphoglucomutase-2	612	68283	6.28	0	Cytoplasm;Cytoskeleton	NA	Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity.	NA	Belongs to the phosphohexose mutase family.	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2.;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Galactose metabolism;Purine metabolism;Starch and sucrose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Pentose phosphate pathway;Glycogen synthesis;Glycogen breakdown (glycogenolysis);Galactose catabolism;Neutrophil degranulation	PE1	4
+NX_Q96G04	Protein-lysine N-methyltransferase EEF2KMT	330	36915	5.7	0	Cytoplasm	NA	Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.	Protein methylation	PE1	16
+NX_Q96G21	U3 small nucleolar ribonucleoprotein protein IMP4	291	33757	9.49	0	Nucleolus	NA	Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.	NA	NA	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	2
+NX_Q96G23	Ceramide synthase 2	380	44876	9.03	6	Endoplasmic reticulum;Endoplasmic reticulum membrane;Nucleus membrane	NA	Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) chain as acyl donor.	Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity.;Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation.	NA	Lipid metabolism; sphingolipid metabolism.;Sphingolipid de novo biosynthesis	PE1	1
+NX_Q96G25	Mediator of RNA polymerase II transcription subunit 8	268	29080	6.92	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the Mediator complex subunit 8 family.	Protein modification; protein ubiquitination.;Herpes simplex infection;Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	1
+NX_Q96G27	WW domain-binding protein 1	269	29140	5.61	0	Cytosol	NA	NA	NA	NA	NA	PE1	2
+NX_Q96G28	Cilia- and flagella-associated protein 36	342	39447	4.93	0	Cytoplasm;Nucleoplasm;Flagellum;Cytosol;Nucleus	NA	May act as an effector for ARL3.	NA	Belongs to the CFAP36 family.	NA	PE1	2
+NX_Q96G30	Melanocortin-2 receptor accessory protein 2	205	23548	4.92	1	Endoplasmic reticulum membrane;Cell membrane	Obesity	Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo.	NA	Belongs to the MRAP family.	NA	PE1	6
+NX_Q96G42	Kelch domain-containing protein 7B	594	63314	9.25	0	Cell membrane	NA	NA	NA	NA	NA	PE1	22
+NX_Q96G46	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like	650	72594	8.4	0	Nucleoplasm;Cytosol	NA	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.	NA	Belongs to the Dus family. Dus3 subfamily.	NA	PE1	19
+NX_Q96G61	Diphosphoinositol polyphosphate phosphohydrolase 3-beta	164	18559	5.73	0	Cytoplasm;Nucleus	NA	Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.	NA	Belongs to the Nudix hydrolase family. DIPP subfamily.	Synthesis of pyrophosphates in the cytosol	PE1	X
+NX_Q96G74	OTU domain-containing protein 5	571	60626	6.1	0	Nucleoplasm;Cytosol;Nucleolus	NA	Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro).	Phosphorylation at Ser-177 is required for deubiquitinating activity.	Belongs to the peptidase C85 family.	RIG-I-like receptor signaling pathway;Negative regulators of DDX58/IFIH1 signaling;Ovarian tumor domain proteases	PE1	X
+NX_Q96G75	E3 ubiquitin-protein transferase RMND5B	393	44414	6.15	0	Nucleoplasm;Cytosol	NA	Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).	NA	NA	NA	PE1	5
+NX_Q96G79	Probable UDP-sugar transporter protein SLC35A4	324	34593	9.77	9	Nucleoplasm;Golgi apparatus membrane	NA	NA	NA	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.	NA	PE2	5
+NX_Q96G91	P2Y purinoceptor 11	374	40345	9.35	7	Cell membrane	NA	Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;G alpha (s) signalling events;P2Y receptors	PE1	19
+NX_Q96G97	Seipin	398	44392	5.07	2	Endoplasmic reticulum membrane	Congenital generalized lipodystrophy 2;Encephalopathy, progressive, with or without lipodystrophy;Neuronopathy, distal hereditary motor, 5A;Spastic paraplegia 17, autosomal dominant	Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues.	NA	Belongs to the seipin family.	NA	PE1	11
+NX_Q96GA3	Protein LTV1 homolog	475	54855	4.8	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the LTV1 family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	6
+NX_Q96GA7	Serine dehydratase-like	329	34674	6.41	0	Cytosol	NA	Has low serine dehydratase and threonine dehydratase activity.	NA	Belongs to the serine/threonine dehydratase family.	Threonine catabolism	PE1	12
+NX_Q96GC5	39S ribosomal protein L48, mitochondrial	212	23935	9.04	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL48 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	11
+NX_Q96GC6	Neurotrophin receptor-interacting factor homolog	653	74177	6.3	0	Nucleoplasm;Cytoplasm;Centrosome;Nucleolus	NA	Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96GC9	Vacuole membrane protein 1	406	46238	6.47	7	Golgi apparatus;Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment membrane;Cell membrane;Vacuole membrane;Nucleolus;Endoplasmic reticulum	NA	Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (PubMed:17724469). Required for autophagosome formation (PubMed:30093494).	NA	Belongs to the VMP1 family.	NA	PE1	17
+NX_Q96GD0	Pyridoxal phosphate phosphatase	296	31698	6.12	0	Cell membrane;Lamellipodium membrane;Ruffle membrane;Cytosol;Cytoskeleton	NA	Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine (PubMed:15580268). Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP (PubMed:14522954).	NA	Belongs to the HAD-like hydrolase superfamily.	Vitamin B6 metabolism;Metabolic pathways	PE1	22
+NX_Q96GD3	Polycomb protein SCMH1	660	73354	9.37	0	Nucleoplasm;Cytosol;Nucleus	NA	Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.	NA	Belongs to the SCM family.	SUMOylation of DNA damage response and repair proteins;Oxidative Stress Induced Senescence;SUMOylation of RNA binding proteins;SUMOylation of chromatin organization proteins;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins	PE1	1
+NX_Q96GD4	Aurora kinase B	344	39311	9.36	0	Chromosome;Midbody;Centromere;Nucleoplasm;Spindle;Nucleus	NA	Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.	The phosphorylation of Thr-232 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism. Thr-232 phosphorylation is indispensable for the AURKB kinase activity.;Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.;AURKB is phosphorylated by CHEK1;AURKB is phosphorylated by LATS1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;SUMOylation of DNA replication proteins;Regulation of TP53 Activity through Phosphorylation;Regulation of MECP2 expression and activity	PE1	17
+NX_Q96GE4	Centrosomal protein of 95 kDa	821	95297	8.76	0	Nucleoplasm;Spindle pole;Centrosome;Cytoplasmic vesicle;Spindle	NA	NA	NA	NA	NA	PE1	17
+NX_Q96GE5	Zinc finger protein 799	643	74288	9.29	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96GE6	Calmodulin-like protein 4	196	21883	7.02	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the calmodulin family.	NA	PE1	15
+NX_Q96GE9	Distal membrane-arm assembly complex protein 1	116	12257	9.8	2	Mitochondrion inner membrane	NA	Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.	NA	NA	NA	PE1	9
+NX_Q96GF1	E3 ubiquitin-protein ligase RNF185	192	20459	6.09	2	Mitochondrion outer membrane;Endoplasmic reticulum membrane	NA	E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036). Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521).	NA	NA	Protein modification; protein ubiquitination.;ER Quality Control Compartment (ERQC);ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis	PE1	22
+NX_Q96GG9	DCN1-like protein 1	259	30124	5.18	0	Nucleoplasm;Cytosol;Nucleus	NA	Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).	NA	NA	Neddylation	PE1	3
+NX_Q96GI7	Protein FAM89A	184	19569	5.64	0	Golgi apparatus;Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	Belongs to the FAM89 family.	NA	PE1	1
+NX_Q96GJ1	tRNA (uracil(54)-C(5))-methyltransferase homolog	504	56476	9.04	0	Nucleoplasm;Nucleus	NA	Probable S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation (By similarity).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.	NA	PE1	X
+NX_Q96GK7	Fumarylacetoacetate hydrolase domain-containing protein 2A	314	34596	8.48	0	NA	NA	May have hydrolase activity.	NA	Belongs to the FAH family.	NA	PE1	2
+NX_Q96GL9	Protein FAM163A	167	17641	5.56	1	Membrane	NA	NA	NA	Belongs to the FAM163 family.	NA	PE1	1
+NX_Q96GM1	Phospholipid phosphatase-related protein type 2	343	36880	9.64	6	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the PA-phosphatase related phosphoesterase family.	Lysosphingolipid and LPA receptors	PE1	19
+NX_Q96GM5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	515	58233	9.31	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342).	NA	Belongs to the SMARCD family.	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	PE1	12
+NX_Q96GM8	Target of EGR1 protein 1	510	56548	6.76	0	Nucleoplasm;Nucleus;Nucleus speckle;Nucleolus	Pontocerebellar hypoplasia 7	Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).	NA	Belongs to the CAF1 family.	NA	PE1	1
+NX_Q96GN5	Cell division cycle-associated 7-like protein	454	52206	5.59	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.	NA	NA	NA	PE1	7
+NX_Q96GP6	Scavenger receptor class F member 2	871	92384	8.77	1	Membrane;Nucleoplasm;Cytosol;Nucleus	Van den Ende-Gupta syndrome	Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity).	NA	NA	NA	PE1	22
+NX_Q96GQ5	RUS1 family protein C16orf58	468	51018	6.47	1	Golgi apparatus;Nucleolus;Membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the RUS1 family.	NA	PE1	16
+NX_Q96GQ7	Probable ATP-dependent RNA helicase DDX27	796	89835	9.33	0	Nucleolus;Chromosome	NA	Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154).	NA	Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.	NA	PE1	20
+NX_Q96GR2	Long-chain-fatty-acid--CoA ligase ACSBG1	724	81290	5.73	0	Cytoplasm;Microsome;Cell membrane;Endoplasmic reticulum;Cytoplasmic vesicle	NA	Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:12975357, PubMed:24269233, PubMed:10954726). Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:10954726).	NA	Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.	Fatty acid metabolism;Metabolic pathways;PPAR signaling pathway;Adipocytokine signaling pathway;Synthesis of very long-chain fatty acyl-CoAs	PE1	15
+NX_Q96GR4	Probable palmitoyltransferase ZDHHC12	267	30813	6.75	4	Membrane;Nucleoplasm;Cytoskeleton	NA	NA	NA	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	9
+NX_Q96GS4	BLOC-1-related complex subunit 6	357	37226	5.56	0	Cytosol;Lysosome membrane;Centrosome	NA	As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.	NA	Belongs to the BORCS6 family.	NA	PE1	17
+NX_Q96GS6	Alpha/beta hydrolase domain-containing protein 17A	310	33990	6.39	0	Dendritic spine;Endosome membrane;Cell membrane;Postsynaptic density;Cytoplasmic vesicle	NA	Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards NRAS (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). May have depalmitoylating activity towards MAP6 (By similarity).	Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization (PubMed:26701913). Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95 (By similarity).	Belongs to the AB hydrolase superfamily. ABHD17 family.	NA	PE1	19
+NX_Q96GT9	X antigen family member 2	111	12354	5.12	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q96GU1	P antigen family member 5	130	14046	4.27	0	Mitochondrion	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q96GV9	UNC119-binding protein C5orf30	206	23083	9.51	0	Cytoplasm;Cilium	NA	Probably plays a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962).	NA	Belongs to the UNC119-binding protein family.	NA	PE1	5
+NX_Q96GW7	Brevican core protein	911	99118	4.57	0	Membrane;Extracellular matrix	NA	May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.	Contains mostly chondroitin sulfate (By similarity). O-glycosylated with a core 1 or possibly core 8 glycan.	Belongs to the aggrecan/versican proteoglycan family.	Degradation of the extracellular matrix;Chondroitin sulfate biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;ECM proteoglycans;Dermatan sulfate biosynthesis;CS/DS degradation;Defective CHST3 causes SEDCJD;Defective CHST14 causes EDS, musculocontractural type;Defective CHSY1 causes TPBS;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	1
+NX_Q96GW9	Methionine--tRNA ligase, mitochondrial	593	66591	8.38	0	Mitochondrion matrix	Combined oxidative phosphorylation deficiency 25;Spastic ataxia 3, autosomal recessive	NA	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Selenocompound metabolism;Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	2
+NX_Q96GX1	Tectonic-2	697	76871	5.09	1	Golgi apparatus;Cytoplasmic vesicle;Membrane;Cilium basal body	Joubert syndrome 24;Meckel syndrome 8	Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity).	NA	Belongs to the tectonic family.	Anchoring of the basal body to the plasma membrane	PE1	12
+NX_Q96GX2	Ataxin-7-like protein 3B	97	10771	4.27	0	Nucleoplasm;Cytoplasm	NA	By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3.	NA	Belongs to the SGF11 family.	NA	PE1	12
+NX_Q96GX5	Serine/threonine-protein kinase greatwall	879	97319	5.67	0	Nucleoplasm;Centrosome;Cleavage furrow;Nucleus	NA	Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.	Phosphorylation at Thr-741 by CDK1 during M phase activates its kinase activity (By similarity). Maximum phosphorylation occurs in prometaphase.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	MASTL Facilitates Mitotic Progression	PE1	10
+NX_Q96GX8	Uncharacterized protein C16orf74	76	8118	4.13	0	Centrosome;Cell membrane	NA	NA	NA	NA	NA	PE1	16
+NX_Q96GX9	Methylthioribulose-1-phosphate dehydratase	242	27125	6.7	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.	NA	Belongs to the aldolase class II family. MtnB subfamily.	Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.;Cysteine and methionine metabolism;Metabolic pathways;Methionine salvage pathway;Formation of apoptosome;Regulation of the apoptosome activity	PE1	11
+NX_Q96GY0	Zinc finger C2HC domain-containing protein 1A	325	35092	9.86	0	Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the ZC2HC1 family.	NA	PE1	8
+NX_Q96GY3	Protein lin-37 homolog	246	28383	8.93	0	Nucleoplasm	NA	NA	NA	NA	G0 and Early G1;G1/S-Specific Transcription;Polo-like kinase mediated events;Cyclin E associated events during G1/S transition;Cyclin A:Cdk2-associated events at S phase entry;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	PE1	19
+NX_Q96GZ6	Solute carrier family 41 member 3	507	54767	7.97	10	Endoplasmic reticulum;Cell membrane	NA	NA	NA	Belongs to the SLC41A transporter family.	NA	PE1	3
+NX_Q96H12	Myb/SANT-like DNA-binding domain-containing protein 3	275	32363	8.58	0	Cytoplasm;Nucleoplasm	NA	NA	NA	Belongs to the MSANTD3 family.	NA	PE1	9
+NX_Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	378	41578	5.75	1	Membrane	NA	Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).	NA	Belongs to the immunoglobulin superfamily. TIM family.	NA	PE1	5
+NX_Q96H20	Vacuolar-sorting protein SNF8	258	28864	6.2	0	Cytoplasm;Endosome membrane;Late endosome membrane;Nucleoplasm;Cytosol;Nucleus	NA	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).	NA	Belongs to the SNF8 family.	Endocytosis;Endosomal Sorting Complex Required For Transport (ESCRT)	PE1	17
+NX_Q96H22	Centromere protein N	339	39555	9.18	0	Kinetochore;Nucleoplasm;Nucleus	NA	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.	NA	Belongs to the CENP-N/CHL4 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	16
+NX_Q96H35	Probable RNA-binding protein 18	190	21649	9.46	0	Midbody;Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	9
+NX_Q96H40	Zinc finger protein 486	463	53631	9.27	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96H55	Unconventional myosin-XIX	970	109135	7.87	0	Mitochondrion outer membrane;Cytosol;Mitochondrion;Cytoskeleton	NA	Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	17
+NX_Q96H72	Zinc transporter ZIP13	371	39011	5.21	8	Golgi apparatus membrane	Ehlers-Danlos syndrome, spondylodysplastic type, 3	Acts as a zinc-influx transporter.	NA	Belongs to the ZIP transporter (TC 2.A.5) family.	NA	PE1	11
+NX_Q96H78	Solute carrier family 25 member 44	314	35392	9.64	6	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	NA	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	1
+NX_Q96H79	Zinc finger CCCH-type antiviral protein 1-like	300	32962	8.5	0	Cytosol	NA	NA	NA	NA	NA	PE1	7
+NX_Q96H86	Zinc finger protein 764	408	44943	9.19	0	Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_Q96H96	4-hydroxybenzoate polyprenyltransferase, mitochondrial	371	40489	9.27	9	Cytosol;Mitochondrion inner membrane	Coenzyme Q10 deficiency, primary, 1;Multiple system atrophy 1	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	NA	Belongs to the UbiA prenyltransferase family.	Cofactor biosynthesis; ubiquinone biosynthesis.;Ubiquinone and other terpenoid-quinone biosynthesis;Metabolic pathways;Mitochondrial protein import;Ubiquinol biosynthesis	PE1	4
+NX_Q96HA1	Nuclear envelope pore membrane protein POM 121	1249	127720	10.58	1	Endoplasmic reticulum membrane;Nucleus membrane;Nuclear pore complex	NA	Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).	NA	Belongs to the POM121 family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	7
+NX_Q96HA4	Uncharacterized protein C1orf159	380	40283	10.07	1	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q96HA7	Tonsoku-like protein	1378	150929	5.99	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.	NA	Belongs to the Tonsoku family.	NA	PE1	8
+NX_Q96HA8	Protein N-terminal glutamine amidohydrolase	205	23680	5.46	0	Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.	NA	Belongs to the NTAQ1 family.	NA	PE1	8
+NX_Q96HA9	Peroxisomal membrane protein 11C	241	26636	9.35	2	Peroxisome membrane	NA	Promotes membrane protrusion and elongation on the peroxisomal surface.	NA	Belongs to the peroxin-11 family.	Peroxisome	PE1	19
+NX_Q96HB5	Coiled-coil domain-containing protein 120	630	67567	9.51	0	Cytoplasm;Mitochondrion;Centriole;Growth cone;Endosome;Neuron projection	NA	Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth.	Ubiquitinated; interaction with CYTH2 may prevent ubiquitination.	NA	NA	PE1	X
+NX_Q96HC4	PDZ and LIM domain protein 5	596	63945	8.55	0	Cell membrane;Focal adhesion;Postsynapse;Nucleoplasm;Presynapse;Postsynaptic density;Cytosol	NA	May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).	NA	NA	Neurexins and neuroligins	PE1	4
+NX_Q96HD1	Protein disulfide isomerase CRELD1	420	45440	4.81	2	Golgi apparatus;Nucleolus;Membrane;Endoplasmic reticulum;Cytosol	Atrioventricular septal defect 2	Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity).	NA	Belongs to the CRELD family.	NA	PE1	3
+NX_Q96HD9	N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)	319	35241	5.57	0	Cytoplasm;Apical cell membrane	NA	Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity).	NA	Belongs to the AspA/AstE family. Aspartoacylase subfamily.	Alanine, aspartate and glutamate metabolism;Histidine metabolism;Aflatoxin activation and detoxification	PE1	11
+NX_Q96HE7	ERO1-like protein alpha	468	54393	5.48	0	Endoplasmic reticulum membrane	NA	Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.	N-glycosylated.;The Cys-94/Cys-99 and Cys-394/Cys-397 disulfide bonds constitute the redox-active center. The Cys-94/Cys-99 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys-394/Cys-397 (By similarity). The regulatory Cys-99/Cys-104 disulfide bond stabilizes the other regulatory bond Cys-94/Cys-131 (PubMed:23027870).	Belongs to the EROs family.	Protein processing in endoplasmic reticulum;Vibrio cholerae infection;Insulin processing;Detoxification of Reactive Oxygen Species	PE1	14
+NX_Q96HE8	Transmembrane protein 80	216	23077	10.55	4	Membrane;Golgi apparatus;Cilium	NA	NA	NA	NA	NA	PE2	11
+NX_Q96HE9	Proline-rich protein 11	360	40085	10.13	0	Endoplasmic reticulum;Cytoplasm;Nucleus	NA	Plays a critical role in cell cycle progression.	Ubiquitinated (Probable). Rapidly degraded by the proteasome; degradation may involve FBXW7-specific phosphorylated phosphodegron motifs.	NA	NA	PE1	17
+NX_Q96HF1	Secreted frizzled-related protein 2	295	33490	7.41	0	Secreted;Cytoskeleton	NA	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.	NA	Belongs to the secreted frizzled-related protein (sFRP) family.	Wnt signaling pathway;TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists	PE1	4
+NX_Q96HG1	Small integral membrane protein 10	83	9236	10.36	1	Membrane	NA	NA	NA	NA	NA	PE1	X
+NX_Q96HH4	Transmembrane protein 169	297	33611	4.76	2	Membrane;Nucleoplasm;Cytosol;Centrosome	NA	NA	NA	NA	NA	PE1	2
+NX_Q96HH6	Transmembrane protein 19	336	36392	8.73	6	Membrane	NA	NA	NA	Belongs to the TMEM19 family.	NA	PE1	12
+NX_Q96HH9	GRAM domain-containing protein 2B	432	47869	8	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	5
+NX_Q96HI0	Sentrin-specific protease 5	755	86693	9.3	0	Nucleolus;Cell membrane	NA	Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.	NA	Belongs to the peptidase C48 family.	SUMO is proteolytically processed	PE1	3
+NX_Q96HJ3	Coiled-coil domain-containing protein 34	373	43225	7.06	0	Nucleolus;Nucleus membrane	NA	NA	NA	NA	NA	PE1	11
+NX_Q96HJ5	Membrane-spanning 4-domains subfamily A member 3	214	22933	5.18	4	Golgi apparatus;Endomembrane system;Perinuclear region;Cytoplasmic vesicle	NA	Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).	NA	Belongs to the MS4A family.	Neutrophil degranulation	PE1	11
+NX_Q96HJ9	Protein FMC1 homolog	113	12749	10.08	0	Mitochondrion	NA	Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) (PubMed:28719601).	NA	Belongs to the FMC1 family.	NA	PE1	7
+NX_Q96HL8	SH3 domain-containing YSC84-like protein 1	342	37148	9.18	0	Nucleoplasm	NA	NA	NA	Belongs to the SH3YL1 family.	NA	PE1	2
+NX_Q96HM7	PC-esterase domain-containing protein 1B	432	49727	9.58	0	Golgi apparatus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the PC-esterase family.	NA	PE1	12
+NX_Q96HN2	Adenosylhomocysteinase 3	611	66721	7.13	0	Nucleoplasm;Cytosol;Cytoplasm;Microsome	NA	May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705).	Phosphorylated during neuronal differentiation at the LISN domain.	Belongs to the adenosylhomocysteinase family.	Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.;Cysteine and methionine metabolism;Metabolic pathways;Bicarbonate transporters	PE1	7
+NX_Q96HP0	Dedicator of cytokinesis protein 6	2047	229558	6.28	0	Cytoplasm;Cytosol;Perinuclear region	Adams-Oliver syndrome 2	Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity).	NA	Belongs to the DOCK family.	Factors involved in megakaryocyte development and platelet production	PE1	19
+NX_Q96HP4	Oxidoreductase NAD-binding domain-containing protein 1	312	34854	8.68	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	3
+NX_Q96HP8	Transmembrane protein 176A	235	26116	8.83	4	Membrane;Mitochondrion	NA	NA	NA	Belongs to the TMEM176 family.	NA	PE1	7
+NX_Q96HQ0	Zinc finger protein 419	510	58564	9.22	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96HQ2	CDKN2AIP N-terminal-like protein	116	13196	4.87	0	NA	NA	NA	NA	Belongs to the CARF family.	NA	PE1	5
+NX_Q96HR3	Mediator of RNA polymerase II transcription subunit 30	178	20277	8.45	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 30 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	8
+NX_Q96HR8	H/ACA ribonucleoprotein complex non-core subunit NAF1	494	53717	4.76	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.	NA	Belongs to the NAF1 family.	NA	PE1	4
+NX_Q96HR9	Receptor expression-enhancing protein 6	211	23418	8.74	2	Endoplasmic reticulum;Endoplasmic reticulum membrane;Clathrin-coated vesicle membrane	Retinitis pigmentosa 77	Required for correct function and survival of retinal photoreceptors (PubMed:27889058). Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity).	NA	Belongs to the DP1 family.	Olfactory Signaling Pathway	PE1	19
+NX_Q96HS1	Serine/threonine-protein phosphatase PGAM5, mitochondrial	289	32004	8.88	1	Mitochondrion outer membrane;Mitochondrion	NA	Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.	Both isoform 1 and isoform 2 are phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity.	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.	Receptor Mediated Mitophagy	PE1	12
+NX_Q96HT8	MORF4 family-associated protein 1-like 1	127	14808	4.46	0	NA	NA	NA	NA	Belongs to the MORF4 family-associated protein family.	NA	PE1	4
+NX_Q96HU1	Small G protein signaling modulator 3	749	85354	5.66	0	Golgi apparatus;Cytoplasm	NA	May play a cooperative role in NF2-mediated growth suppression of cells.	NA	Belongs to the small G protein signaling modulator family.	NA	PE1	22
+NX_Q96HU8	GTP-binding protein Di-Ras2	199	22485	8.98	0	Cell membrane	NA	Displays low GTPase activity and exists predominantly in the GTP-bound form.	NA	Belongs to the small GTPase superfamily. Di-Ras family.	NA	PE1	9
+NX_Q96HV5	Transmembrane protein 41A	264	29665	9.23	5	Membrane;Nucleoplasm;Golgi apparatus;Cytosol	NA	NA	NA	Belongs to the TMEM41 family.	NA	PE1	3
+NX_Q96HW7	Integrator complex subunit 4	963	108171	6	0	Nucleolus;Nucleus	NA	Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).	NA	Belongs to the Integrator subunit 4 family.	RNA polymerase II transcribes snRNA genes	PE1	11
+NX_Q96HY6	DDRGK domain-containing protein 1	314	35611	5.12	0	Endoplasmic reticulum;Nucleolus	Spondyloepimetaphyseal dysplasia, Shohat type	Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186).	Ubiquitinated. Ubiquitination probably triggers proteasomal degradation and is negatively regulated by UFL1, the enzyme involved in the ufmylation of DDRGK1.;Ufmylated. Conjugated to ubiquitin-like protein UFM1, probably at Lys-267 by UFL1.	Belongs to the DDRGK1 family.	NA	PE1	20
+NX_Q96HY7	Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial	919	103077	6.46	0	Mitochondrion	2-aminoadipic 2-oxoadipic aciduria;Charcot-Marie-Tooth disease 2Q	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).	NA	Belongs to the alpha-ketoglutarate dehydrogenase family.	Glyoxylate metabolism and glycine degradation	PE1	10
+NX_Q96HZ4	Transcription cofactor HES-6	224	24129	5.18	0	Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).	NA	NA	NA	PE1	2
+NX_Q96HZ7	Putative uncharacterized protein URB1-AS1	61	6513	12.37	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_Q96I13	Protein ABHD8	439	47331	6.54	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the AB hydrolase superfamily.	NA	PE1	19
+NX_Q96I15	Selenocysteine lyase	445	48149	6.63	0	Golgi apparatus;Cytosol	NA	Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.	NA	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.	Selenocompound metabolism;Metabolic pathways;Metabolism of ingested SeMet, Sec, MeSec into H2Se	PE1	2
+NX_Q96I23	Protein preY, mitochondrial	114	12655	9.45	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the PREY family.	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways	PE1	4
+NX_Q96I24	Far upstream element-binding protein 3	572	61640	8.6	0	Nucleoplasm;Cytosol;Nucleus	NA	May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.	NA	NA	NA	PE1	9
+NX_Q96I25	Splicing factor 45	401	44962	5.76	0	Nucleoplasm;Nucleus	NA	Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.	NA	NA	Spliceosome;mRNA Splicing - Major Pathway	PE1	10
+NX_Q96I27	Zinc finger protein 625	306	34746	9.21	0	Nucleoplasm;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96I34	Protein phosphatase 1 regulatory subunit 16A	528	57811	5.68	0	Cell membrane	NA	Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.	NA	NA	NA	PE1	8
+NX_Q96I36	Cytochrome c oxidase assembly protein COX14	57	6600	9.58	1	Mitochondrion membrane;Mitochondrion	NA	Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1.	NA	NA	Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	12
+NX_Q96I45	Transmembrane protein 141	108	11875	8.69	2	Membrane;Cell junction;Mitochondrion	NA	NA	NA	Belongs to the TMEM141 family.	NA	PE1	9
+NX_Q96I51	RCC1-like G exchanging factor-like protein	464	49997	8.74	0	Mitochondrion;Nucleoplasm;Mitochondrion membrane;Cytosol;Mitochondrion inner membrane	NA	Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (PubMed:27667664).	NA	NA	NA	PE1	7
+NX_Q96I59	Probable asparagine--tRNA ligase, mitochondrial	477	54090	6.79	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion;Cytosol	Deafness, autosomal recessive, 94;Combined oxidative phosphorylation deficiency 24	NA	NA	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	11
+NX_Q96I76	G patch domain-containing protein 3	525	59338	4.93	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768).	NA	NA	NA	PE1	1
+NX_Q96I82	Kazal-type serine protease inhibitor domain-containing protein 1	304	32945	4.67	0	Extracellular matrix	NA	Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly (By similarity).	NA	NA	NA	PE1	10
+NX_Q96I99	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial	432	46511	6.15	0	Mitochondrion;Cell membrane	NA	GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	NA	Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.	Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.;Citrate cycle (TCA cycle);Propanoate metabolism;Metabolic pathways;Citric acid cycle (TCA cycle)	PE1	3
+NX_Q96IC2	RNA exonuclease 5	774	86886	8.64	0	Endoplasmic reticulum;Nucleolus;Nucleus membrane;Nucleus	NA	NA	NA	NA	NA	PE1	16
+NX_Q96ID5	Immunoglobulin superfamily member 21	467	51835	6.48	0	Postsynaptic cell membrane	NA	Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.	NA	NA	NA	PE1	1
+NX_Q96IF1	LIM domain-containing protein ajuba	538	56934	6.86	0	Golgi apparatus;Cell membrane;Cell junction;Nucleoplasm;P-body;Centrosome;Nucleus;Cytoskeleton	NA	Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.	Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA.;AJUBA is phosphorylated by LATS2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);AJUBA is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the zyxin/ajuba family.	Regulation of PLK1 Activity at G2/M Transition;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	14
+NX_Q96IG2	F-box/LRR-repeat protein 20	436	48423	7.65	0	Cytoplasm;Cytoskeleton	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	17
+NX_Q96II8	DISP complex protein LRCH3	777	86083	6.25	0	Cytoplasm;Cytosol	NA	As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton.	NA	NA	NA	PE1	3
+NX_Q96IJ6	Mannose-1-phosphate guanyltransferase alpha	420	46291	6.73	0	Nucleoplasm;Cytoplasm	Alacrima, achalasia, and mental retardation syndrome	May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.	NA	Belongs to the transferase hexapeptide repeat family.	Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Synthesis of GDP-mannose	PE1	2
+NX_Q96IK0	Transmembrane protein 101	257	28795	9.62	8	Membrane;Nucleoplasm;Cytosol;Cell membrane	NA	May activate NF-kappa-B signaling pathways.	NA	NA	NA	PE1	17
+NX_Q96IK1	Biorientation of chromosomes in cell division protein 1	185	19196	5.89	0	Centrosome;Kinetochore	NA	Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.	NA	Belongs to the BOD1 family.	NA	PE1	5
+NX_Q96IK5	Germ cell-less protein-like 1	515	58685	7.42	0	Nucleus matrix	NA	Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	NA	NA	NA	PE1	2
+NX_Q96IL0	Cytochrome c oxidase assembly factor 8	206	24153	9.99	0	Mitochondrion inner membrane	Mitochondrial complex IV deficiency	Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain.	N-terminal mitochondrial targeting sequence is cleaved from the mature protein once in the mitochondrion.;In normal conditions, the cytoplasmic precursor protein is rapidly degraded by the ubiquitination-proteasome system (UPS). Oxidative stress induces protein stabilization and import into mitochondria where it protects COX from degradation.	Belongs to the COA8 family.	NA	PE1	14
+NX_Q96IM9	DPY30 domain-containing protein 2	177	20586	5.46	0	NA	NA	NA	NA	Belongs to the dpy-30 family.	NA	PE1	10
+NX_Q96IP4	Terminal nucleotidyltransferase 5A	442	49666	5.03	0	NA	Osteogenesis imperfecta 18	Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.	NA	Belongs to the TENT family.	NA	PE1	6
+NX_Q96IQ7	V-set and immunoglobulin domain-containing protein 2	327	34348	7.5	1	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	11
+NX_Q96IQ9	Zinc finger protein 414	312	32782	8.02	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q96IR2	Zinc finger protein 845	970	113133	9.47	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q96IR3	Putative uncharacterized protein MGC15705	41	4679	5.05	0	NA	NA	NA	NA	NA	NA	PE5	22
+NX_Q96IR7	4-hydroxyphenylpyruvate dioxygenase-like protein	371	39386	6.55	0	Mitochondrion	NA	May have dioxygenase activity.	NA	Belongs to the 4HPPD family.	NA	PE1	1
+NX_Q96IS3	Retina and anterior neural fold homeobox protein 2	184	20086	9.45	0	Nucleus	Macular degeneration, age-related, 6;Cone-rod dystrophy 11	May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter.	NA	NA	NA	PE1	19
+NX_Q96IT1	Zinc finger protein 496	587	66908	5.48	0	Golgi apparatus;Nucleus	NA	DNA-binding transcription factor that can both act as an activator and a repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q96IT6	Putative uncharacterized protein ARHGAP5-AS1	56	6106	10.42	0	NA	NA	NA	NA	NA	NA	PE5	14
+NX_Q96IU2	Zinc finger BED domain-containing protein 3	234	25132	8.65	0	Membrane;Cytoplasm;Nucleoplasm;Cell membrane	NA	Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity).	NA	NA	NA	PE1	5
+NX_Q96IU4	Protein ABHD14B	210	22346	5.94	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription.	NA	Belongs to the AB hydrolase superfamily. ABHD14 family.	Cytosolic sulfonation of small molecules	PE1	3
+NX_Q96IV0	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	654	74390	6.47	0	Cytoplasm	Congenital disorder of deglycosylation	Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.	NA	Belongs to the transglutaminase-like superfamily. PNGase family.	Protein processing in endoplasmic reticulum;N-glycan trimming in the ER and Calnexin/Calreticulin cycle	PE1	3
+NX_Q96IV6	Fatty acid hydroxylase domain-containing protein 2	333	39002	9.01	5	Membrane	NA	NA	NA	Belongs to the sterol desaturase family.	Steroid biosynthesis;Metabolic pathways	PE1	5
+NX_Q96IW2	SH2 domain-containing adapter protein D	340	38264	4.88	0	Cytosol;Centriolar satellite	NA	May function as an adapter protein.	Tyrosine phosphorylated by ABL.;SHD is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	NA	NA	PE1	19
+NX_Q96IW7	Vesicle-trafficking protein SEC22a	307	34948	8.57	4	Endoplasmic reticulum membrane	NA	May be involved in vesicle transport between the ER and the Golgi complex.	NA	Belongs to the synaptobrevin family.	COPII-mediated vesicle transport	PE1	3
+NX_Q96IX5	ATP synthase membrane subunit DAPIT, mitochondrial	58	6458	9.78	1	Mitochondrion membrane;Mitochondrion	NA	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). Minor subunit required to maintain the ATP synthase population in the mitochondria (PubMed:21345788).	NA	NA	NA	PE1	10
+NX_Q96IX9	Putative ankyrin repeat domain-containing protein 26-like 1	119	14172	9.1	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q96IY1	Kinetochore-associated protein NSL1 homolog	281	32162	6.35	0	Kinetochore;Nucleus speckle;Nucleus	NA	Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.	NA	NA	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	1
+NX_Q96IY4	Carboxypeptidase B2	423	48424	7.61	0	Secreted	NA	Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.	N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4.	Belongs to the peptidase M14 family.	Complement and coagulation cascades;Pancreatic secretion;Protein digestion and absorption;Regulation of Complement cascade;Metabolism of Angiotensinogen to Angiotensins	PE1	13
+NX_Q96IZ0	PRKC apoptosis WT1 regulator protein	340	36568	5.35	0	Cytoplasm;Cell membrane;Nucleus;Cytoskeleton	NA	Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.	Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.;PAWR is phosphorylated by DAPK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	12
+NX_Q96IZ2	Androgen-dependent TFPI-regulating protein	230	26842	9.74	6	Nucleolus;Cell membrane	NA	Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574).	NA	Belongs to the AIG1 family.	NA	PE1	6
+NX_Q96IZ5	RNA-binding protein 41	413	47100	8.85	0	Cytoplasm;Cytosol;Nucleus speckle	NA	May bind RNA.	NA	NA	NA	PE1	X
+NX_Q96IZ6	tRNA N(3)-methylcytidine methyltransferase METTL2A	378	43537	5.69	0	NA	NA	S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU).	NA	Belongs to the methyltransferase superfamily. METL family.	NA	PE1	17
+NX_Q96IZ7	Serine/Arginine-related protein 53	334	38677	11.08	0	Cytoplasm;Nucleus speckle;Nucleus	Intellectual developmental disorder, autosomal recessive 70	Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing.	Phosphorylated.	NA	NA	PE1	3
+NX_Q96J01	THO complex subunit 3	351	38772	5.7	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus speckle;Nucleus	NA	Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.	NA	NA	RNA transport;Spliceosome;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	5
+NX_Q96J02	E3 ubiquitin-protein ligase Itchy homolog	903	102803	5.94	0	Cytoplasm;Endosome membrane;Cell membrane;Nucleoplasm;Early endosome membrane;Cytoplasmic vesicle;Nucleus	Autoimmune disease, multisystem, with facial dysmorphism	Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14602072, PubMed:17028573, PubMed:16387660, PubMed:18718448, PubMed:18718449, PubMed:11046148, PubMed:19592251, PubMed:19116316, PubMed:19881509, PubMed:20491914, PubMed:20392206, PubMed:20068034, PubMed:23146885, PubMed:24790097, PubMed:25631046). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response (PubMed:18718448, PubMed:20491914). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (PubMed:20068034). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).	Monoubiquitinated (PubMed:19116316). Autopolyubiquitinated with 'Lys-63' linkages which does not lead to protein degradation (PubMed:18718449, PubMed:23146885, PubMed:24790097).;On T-cell activation, phosphorylation by the JNK cascade on serine and threonine residues surrounding the PRR domain accelerates the ubiquitination and degradation of JUN and JUNB. The increased ITCH catalytic activity due to phosphorylation by JNK1 may occur due to a conformational change disrupting the interaction between the PRR/WW motifs domain and the HECT domain and, thus exposing the HECT domain (By similarity). Phosphorylation by FYN reduces interaction with JUNB and negatively controls JUN ubiquitination and degradation.;ITCH is phosphorylated by SGK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Protein modification; protein ubiquitination.;Degradation of GLI1 by the proteasome;Hedgehog 'on' state;Antigen processing: Ubiquitination &amp; Proteasome degradation;NOD1/2 Signaling Pathway;Negative regulators of DDX58/IFIH1 signaling;Activated NOTCH1 Transmits Signal to the Nucleus;Downregulation of ERBB4 signaling;RUNX1 regulates transcription of genes involved in differentiation of HSCs	PE1	20
+NX_Q96J42	Thioredoxin domain-containing protein 15	360	39885	4.77	1	Cilium membrane;Golgi apparatus	NA	Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Involved in ciliogenesis (PubMed:27894351).	NA	NA	NA	PE1	5
+NX_Q96J65	Multidrug resistance-associated protein 9	1359	152297	8.64	10	Membrane	NA	Probable transporter.	NA	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.	ABC transporters	PE1	16
+NX_Q96J66	ATP-binding cassette sub-family C member 11	1382	154301	8.39	10	Vacuole membrane;Cytoplasmic vesicle membrane;Cell membrane	NA	Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Enhances the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689).	NA	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.	ABC transporters;ABC-family proteins mediated transport	PE1	16
+NX_Q96J77	Tumor protein D55	140	15503	9.96	0	NA	NA	NA	NA	Belongs to the TPD52 family.	NA	PE1	9
+NX_Q96J84	Kin of IRRE-like protein 1	757	83536	5.49	1	Cell membrane	NA	Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).	N-glycosylated.;Phosphorylation probably regulates the interaction with NSH2. Phosphorylated at Tyr-605 and Tyr-606 by FYN, leading to GRB2 binding (By similarity).	Belongs to the immunoglobulin superfamily.	Nephrin family interactions	PE1	1
+NX_Q96J86	Cysteine and tyrosine-rich protein 1	154	16626	8.28	1	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the CYYR1 family.	NA	PE2	21
+NX_Q96J87	CUGBP Elav-like family member 6	481	50477	8.87	0	Cytoplasm;Nucleus	NA	RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA.	NA	Belongs to the CELF/BRUNOL family.	NA	PE1	15
+NX_Q96J88	Epithelial-stromal interaction protein 1	318	36793	9.9	0	NA	NA	Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity).	NA	NA	NA	PE1	13
+NX_Q96J92	Serine/threonine-protein kinase WNK4	1243	134739	5.36	0	Tight junction	Pseudohypoaldosteronism 2B	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).	Phosphorylated by WNK1 and WNK3.;Ubiquitinated by the BCR(KLHL3) complex, leading to its degradation and increased expression of KCNJ1 at the cell surface. Ubiquitinated by the BCR(KLHL2) complex.;WNK4 is phosphorylated by WNK3 (Phosphoserine:PTM-0253)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.	Stimuli-sensing channels	PE1	17
+NX_Q96J94	Piwi-like protein 1	861	98603	9.5	0	Cytoplasm	NA	May be a negative developmental regulator (PubMed:12037681, PubMed:16287078).;Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. Required to sequester RNF8 in the cytoplasm until late spermatogenesis; RNF8 being released upon ubiquitination and degradation of PIWIL1.	Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) in late spermatids, leading to its degradation (PubMed:28552346). Ubiquitination only takes place following piRNA-binding in adult testis (By similarity). Ubiquitination and degradation in late spermatogenesis by APC/C is probably required to release RNF8 from the cytoplasm and promote histone to protamine exchange by RNF8 (By similarity).;Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein (TDRD1, TDRKH/TDRD2, RNF17/TDRD4, TDRD6, TDRD7 and TDRD9) and subsequent localization to the meiotic nuage, also named P granule.	Belongs to the argonaute family. Piwi subfamily.	Dorso-ventral axis formation;PIWI-interacting RNA (piRNA) biogenesis	PE1	12
+NX_Q96JA1	Leucine-rich repeats and immunoglobulin-like domains protein 1	1093	119113	6.66	1	Cytosol;Cell membrane	NA	Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.	NA	NA	Signaling by EGFR;Negative regulation of MET activity	PE1	3
+NX_Q96JA3	Pleckstrin homology domain-containing family A member 8	519	58261	5.03	0	Membrane;trans-Golgi network membrane	NA	Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.	NA	NA	Synthesis of PIPs at the plasma membrane	PE1	7
+NX_Q96JA4	Membrane-spanning 4-domains subfamily A member 14	679	76580	5.39	4	Membrane;Nucleoplasm;Cell membrane	NA	May be involved in signal transduction as a component of a multimeric receptor complex.	NA	Belongs to the MS4A family.	NA	PE2	11
+NX_Q96JB1	Dynein heavy chain 8, axonemal	4490	514664	5.95	0	Cilium axoneme	NA	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).	NA	Belongs to the dynein heavy chain family.	NA	PE1	6
+NX_Q96JB2	Conserved oligomeric Golgi complex subunit 3	828	94096	5.39	0	Golgi apparatus;Cell membrane;Golgi stack membrane;Nucleoplasm;Cytosol	NA	Involved in ER-Golgi transport.	NA	Belongs to the COG3 family.	Intra-Golgi traffic;COPI-mediated anterograde transport;Retrograde transport at the Trans-Golgi-Network	PE1	13
+NX_Q96JB3	Hypermethylated in cancer 2 protein	615	66156	5.95	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.	NA	PE1	22
+NX_Q96JB5	CDK5 regulatory subunit-associated protein 3	506	56921	4.68	0	Cytoplasm;Nucleolus;Centrosome;Cytoplasmic vesicle;Cytosol;Nucleus	NA	(Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.;Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).	Ubiquitinated. Probably triggers proteasomal degradation and is negatively regulated by UFL1.;Cleaved by caspases early during apoptosis, the resulting peptides may play a role in rupture of the nuclear envelope.;May be ufmylated.;May be phosphorylated by CDK5.	Belongs to the CDK5RAP3 family.	NA	PE1	17
+NX_Q96JB6	Lysyl oxidase homolog 4	756	84483	7.32	0	Cytoplasmic vesicle;Extracellular space	NA	May modulate the formation of a collagenous extracellular matrix.	The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.	Belongs to the lysyl oxidase family.	Elastic fibre formation;Crosslinking of collagen fibrils	PE1	10
+NX_Q96JB8	MAGUK p55 subfamily member 4	637	72779	5.4	0	Cytoplasm;Cytosol;Cytoskeleton	NA	May play a role in retinal photoreceptors development.	NA	Belongs to the MAGUK family.	NA	PE1	2
+NX_Q96JC1	Vam6/Vps39-like protein	886	101809	6.53	0	Cytoplasm;Lysosome membrane;Late endosome;Lysosome;Late endosome membrane	NA	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (PubMed:11448994, PubMed:23351085, PubMed:23167963). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203).;Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation.	NA	Belongs to the VAM6/VPS39 family.	NA	PE1	15
+NX_Q96JC4	Zinc finger protein 479	524	60598	9.21	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	7
+NX_Q96JC9	ELL-associated factor 1	268	29042	5.24	0	Cajal body;Nucleus speckle;Nucleoplasm;Cytoplasmic vesicle;Nucleus;Cytoskeleton	NA	Acts as a transcriptional transactivator of ELL and ELL2 elongation activities.	NA	Belongs to the EAF family.	Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation	PE1	3
+NX_Q96JD6	1,5-anhydro-D-fructose reductase	320	36589	7.19	0	Golgi apparatus;Nucleoplasm;Cytoplasm	NA	Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078).	NA	Belongs to the aldo/keto reductase family.	NA	PE1	10
+NX_Q96JE7	Protein transport protein Sec16B	1060	116604	5.71	0	Endoplasmic reticulum membrane;Cell membrane;Endoplasmic reticulum;Golgi apparatus membrane;Cytoskeleton	NA	Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:21768384, PubMed:22355596). Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes (PubMed:21768384).	NA	Belongs to the SEC16 family.	COPII-mediated vesicle transport	PE1	1
+NX_Q96JE9	Microtubule-associated protein 6	813	86505	9.2	0	Golgi apparatus;Cell membrane;Secretory vesicle membrane;Axon;Dendrite;Cytoskeleton	NA	Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity).	Palmitoylated. Probably depalmitoylated by ABHD17A, ABHD17B and ABHD17C. During neuronal polarization, palmitoylation and depalmitoylation cycles regulate MAP6 shuttling between secretory vesicles and microtubules, and its polarized distribution in the axon.	Belongs to the STOP family.	NA	PE1	11
+NX_Q96JF0	Beta-galactoside alpha-2,6-sialyltransferase 2	529	60158	9.77	1	Golgi stack membrane;Nucleoplasm;Nucleolus	NA	Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.	O-glycosylated.	Belongs to the glycosyltransferase 29 family.	N-Glycan biosynthesis;Other types of O-glycan biosynthesis;Metabolic pathways;Sialic acid metabolism	PE1	2
+NX_Q96JF6	Zinc finger protein 594	807	93907	9.01	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	17
+NX_Q96JG6	Syndetin	964	111174	5.85	0	Recycling endosome;Cytosol;Cell membrane	NA	Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).	NA	Belongs to the syndetin family.	NA	PE1	7
+NX_Q96JG8	Melanoma-associated antigen D4	741	81378	6.34	0	NA	NA	May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.	NA	NA	NA	PE1	X
+NX_Q96JG9	Zinc finger protein 469	3925	410202	7.88	0	Cytoplasmic vesicle;Nucleus	Brittle cornea syndrome 1	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	16
+NX_Q96JH7	Deubiquitinating protein VCIP135	1222	134321	6.77	0	Cytoplasm;Cell membrane;Endoplasmic reticulum;Centrosome;Golgi stack	NA	Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.	NA	NA	Ovarian tumor domain proteases	PE1	8
+NX_Q96JH8	Ras-associating and dilute domain-containing protein	1075	117455	6.67	0	Nucleoplasm;Nucleus membrane	NA	Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.	NA	Belongs to the RADIL family.	NA	PE1	7
+NX_Q96JI7	Spatacsin	2443	278868	5.63	0	Cell membrane;Nucleolus;Cytosol;Axon;Dendrite;Nucleus	Spastic paraplegia 11, autosomal recessive;Amyotrophic lateral sclerosis 5, juvenile;Charcot-Marie-Tooth disease 2X	May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport.	NA	NA	NA	PE1	15
+NX_Q96JJ3	Engulfment and cell motility protein 2	720	82615	5.62	0	Membrane;Cytoplasm;Cytosol	Vascular malformation, primary intraosseous	Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.	NA	NA	Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	PE1	20
+NX_Q96JJ6	Junctophilin-4	628	65861	6.39	1	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane;Cell membrane	NA	Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity).	NA	Belongs to the junctophilin family.	NA	PE1	14
+NX_Q96JJ7	Protein disulfide-isomerase TMX3	454	51872	4.8	1	Endoplasmic reticulum membrane	NA	Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase.	N-glycosylated.	Belongs to the protein disulfide isomerase family.	Platelet degranulation	PE1	18
+NX_Q96JK2	DDB1- and CUL4-associated factor 5	942	103963	5.48	0	Mitochondrion	NA	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	NA	NA	Protein modification; protein ubiquitination.;Neddylation	PE1	14
+NX_Q96JK4	HHIP-like protein 1	782	86731	7.69	0	Secreted	NA	NA	NA	Belongs to the HHIP family.	NA	PE1	14
+NX_Q96JK9	Mastermind-like protein 3	1138	122293	7.12	0	Nucleus speckle	NA	Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.	NA	Belongs to the mastermind family.	Notch signaling pathway;Pre-NOTCH Transcription and Translation;Notch-HLH transcription pathway;NOTCH2 intracellular domain regulates transcription;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE1	4
+NX_Q96JL9	Zinc finger protein 333	665	75544	8.27	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96JM2	Zinc finger protein 462	2506	284688	7.53	0	Nucleoplasm;Nucleus	NA	Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965).	O-GlcNAcylated with O-GlcNAc-6-phosphate.	NA	NA	PE1	9
+NX_Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	812	89099	8.7	0	Kinetochore;Chromosome;Nucleoplasm;Spindle;Nucleus;Midbody ring	Mental retardation, autosomal dominant 40	Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore.	Phosphorylated by CDK1. Mitotic phosphorylation is required for the attachment of spindle microtubules to the kinetochore.	NA	NA	PE1	13
+NX_Q96JM4	Leucine-rich repeat and IQ domain-containing protein 1	1722	199300	5.85	0	NA	NA	NA	NA	NA	NA	PE1	12
+NX_Q96JM7	Lethal(3)malignant brain tumor-like protein 3	780	88337	6.02	0	Nucleoplasm;Nucleus;Nucleolus	NA	Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).	NA	NA	NA	PE1	6
+NX_Q96JN0	Ligand-dependent corepressor	433	47007	9.39	0	Nucleoplasm;Nucleus	NA	May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.	NA	NA	NA	PE1	10
+NX_Q96JN2	Coiled-coil domain-containing protein 136	1154	134045	4.63	1	Acrosome membrane;Nucleolus	NA	May play a role in acrosome formation in spermatogenesis and in fertilization.	NA	NA	NA	PE1	7
+NX_Q96JN8	Neuralized-like protein 4	1562	166907	5.57	0	Centriole	NA	Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers.	Ubiquitinated; undergoes HERC2-dependent 'Lys-48' ubiquitination. This ubiquitination leads to proteasomal degradation.	NA	NA	PE1	17
+NX_Q96JP0	Protein fem-1 homolog C	617	68673	7.6	0	Cytoplasm;Nucleoplasm	NA	Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.	NA	Belongs to the fem-1 family.	Protein modification; protein ubiquitination.;Neddylation	PE1	5
+NX_Q96JP2	Unconventional myosin-XVB	1530	167088	8.75	0	Cytoplasm	NA	Unknown, due to the absence of a functional motor domain.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	17
+NX_Q96JP5	E3 ubiquitin-protein ligase ZFP91	570	63445	7.02	0	Nucleoplasm;Cytosol;Nucleus	NA	Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Protein modification; protein ubiquitination.	PE1	11
+NX_Q96JP9	Cadherin-related family member 1	859	93595	5.34	1	Cell membrane	Cone-rod dystrophy 15	Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity).	Undergoes proteolytic cleavage; produces a soluble 95 kDa N-terminal fragment and a 25 kDa cell-associated C-terminal fragment.	NA	NA	PE1	10
+NX_Q96JQ0	Protocadherin-16	3298	346181	4.79	1	Cell membrane	Mitral valve prolapse 2;Van Maldergem syndrome 1	Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302).	NA	NA	NA	PE1	11
+NX_Q96JQ2	Calmin	1002	111651	4.84	1	Membrane;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	14
+NX_Q96JQ5	Membrane-spanning 4-domains subfamily A member 4A	239	25441	7.63	4	Membrane	NA	May be involved in signal transduction as a component of a multimeric receptor complex.	NA	Belongs to the MS4A family.	NA	PE1	11
+NX_Q96JS3	PiggyBac transposable element-derived protein 1	809	92515	5.45	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	6
+NX_Q96JT2	Solute carrier family 45 member 3	553	59323	7.44	11	Membrane;Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.	Cellular hexose transport	PE1	1
+NX_Q96JW4	Solute carrier family 41 member 2	573	62473	5.69	11	Endoplasmic reticulum;Cell membrane	NA	Acts as a plasma-membrane magnesium transporter.	NA	Belongs to the SLC41A transporter family.	Metal ion SLC transporters	PE1	12
+NX_Q96JX3	Protein SERAC1	654	74147	7.59	1	Membrane;Endoplasmic reticulum;Mitochondrion	3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome	Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway.	NA	Belongs to the SERAC1 family.	NA	PE1	6
+NX_Q96JY0	Protein maelstrom homolog	434	49219	8.94	0	Cytoplasm;Nucleus	NA	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).	NA	Belongs to the maelstrom family.	PIWI-interacting RNA (piRNA) biogenesis	PE1	1
+NX_Q96JY6	PDZ and LIM domain protein 2	352	37459	9	0	Cytoplasm;Focal adhesion;Nucleus;Cytoskeleton	NA	Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.	NA	NA	NA	PE1	8
+NX_Q96JZ2	Hematopoietic SH2 domain-containing protein	352	39002	6.64	0	Cytoplasm;Cell membrane;Focal adhesion;Cytosol;Nucleus	NA	May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.	May be phosphorylated by FES and ACK1.	NA	NA	PE1	19
+NX_Q96K12	Fatty acyl-CoA reductase 2	515	59438	9.44	1	Golgi apparatus;Peroxisome membrane;Nucleolus	NA	Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates (PubMed:15220348). It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity).	NA	Belongs to the fatty acyl-CoA reductase family.	Peroxisome;Wax biosynthesis	PE1	12
+NX_Q96K17	Transcription factor BTF3 homolog 4	158	17271	5.95	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the NAC-beta family.	NA	PE1	1
+NX_Q96K19	E3 ubiquitin-protein ligase RNF170	258	29815	5.34	3	Endoplasmic reticulum;Endoplasmic reticulum membrane	Ataxia, sensory, 1, autosomal dominant	E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.	NA	NA	Protein modification; protein ubiquitination.	PE1	8
+NX_Q96K21	Abscission/NoCut checkpoint regulator	471	51546	5.57	0	Centrosome;Cleavage furrow;Midbody ring	NA	Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.	NA	NA	NA	PE1	15
+NX_Q96K30	RBPJ-interacting and tubulin-associated protein 1	269	28619	11.07	0	Nucleoplasm;Cytoplasm;Centrosome;Nucleus	NA	Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.	NA	Belongs to the RITA family.	NA	PE1	12
+NX_Q96K31	Uncharacterized protein C8orf76	380	43273	5.31	0	NA	NA	NA	NA	NA	NA	PE1	8
+NX_Q96K37	Solute carrier family 35 member E1	410	44773	9.82	9	Membrane;Golgi apparatus	NA	Putative transporter.	NA	Belongs to the TPT transporter family. SLC35E subfamily.	NA	PE1	19
+NX_Q96K49	Transmembrane protein 87B	555	63536	7.16	7	Cytoplasmic vesicle;Golgi apparatus;Golgi apparatus membrane	NA	May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).	NA	Belongs to the LU7TM family. TMEM87 subfamily.	NA	PE1	2
+NX_Q96K58	Zinc finger protein 668	619	67890	9.2	0	Nucleoplasm;Nucleus;Nucleolus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_Q96K62	Zinc finger and BTB domain-containing protein 45	511	54008	6.44	0	Cytosol;Nucleus	NA	May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q96K75	Zinc finger protein 514	400	45938	9.13	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	2
+NX_Q96K76	Ubiquitin carboxyl-terminal hydrolase 47	1375	157311	4.97	0	Cytoplasm	NA	Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.	NA	Belongs to the peptidase C19 family.	Ub-specific processing proteases	PE1	11
+NX_Q96K78	Adhesion G-protein coupled receptor G7	797	88909	8.77	7	Membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	3
+NX_Q96K80	Zinc finger CCCH domain-containing protein 10	434	46052	7.58	0	Cytoplasmic vesicle;Nucleus	NA	Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA.	NA	NA	NA	PE1	12
+NX_Q96K83	Zinc finger protein 521	1311	147866	6.56	0	Nucleoplasm;Nucleus	NA	Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	RUNX2 regulates osteoblast differentiation	PE1	18
+NX_Q96KA5	Cleft lip and palate transmembrane protein 1-like protein	538	62229	8.71	6	Membrane;Endoplasmic reticulum	NA	Enhances cisplatin-mediated apoptosis, when overexpressed.	NA	Belongs to the CLPTM1 family.	NA	PE1	5
+NX_Q96KB5	Lymphokine-activated killer T-cell-originated protein kinase	322	36085	4.98	0	Cytosol	NA	Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.	Phosphorylated; in a cell-cycle dependent manner at mitosis.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	NA	PE1	8
+NX_Q96KC2	ADP-ribosylation factor-like protein 5B	179	20375	6.06	0	NA	NA	Binds and exchanges GTP and GDP.	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	10
+NX_Q96KC8	DnaJ homolog subfamily C member 1	554	63883	8.77	1	Microsome membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane;Nucleus membrane	NA	May modulate protein synthesis.	NA	NA	Protein processing in endoplasmic reticulum	PE1	10
+NX_Q96KC9	Calcium-binding and spermatid-specific protein 1	395	43003	4.07	0	Cytoplasm;Mitochondrion;Flagellum	NA	NA	NA	NA	NA	PE1	4
+NX_Q96KD3	Protein FAM71F1	344	38946	9.51	0	Cytosol	NA	NA	NA	Belongs to the FAM71 family.	NA	PE2	7
+NX_Q96KE9	BTB/POZ domain-containing protein 6	485	53411	5.87	0	Cytoplasm;Nucleoplasm	NA	Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (By similarity).	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	14
+NX_Q96KF2	Small nuclear protein PRAC1	57	5959	9.9	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE2	17
+NX_Q96KF7	Small integral membrane protein 8	97	11059	9.3	1	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the SMIM8 family.	NA	PE1	6
+NX_Q96KG7	Multiple epidermal growth factor-like domains protein 10	1140	122205	6.5	1	Phagocytic cup;Cell membrane	Myopathy, early-onset, areflexia, respiratory distress, and dysphagia	Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568, PubMed:17643423). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977, Ref.14). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:17498693, PubMed:17643423, PubMed:20828568, PubMed:22101682, PubMed:27170117, PubMed:28498977).	Ubiquitinated; mono- and polyubiquitinated forms are detected.;Phosphorylated on tyrosine residues. Phosphorylation at Tyr-1030 may be important for muscle cell proliferation.	Belongs to the MEGF family.	NA	PE1	5
+NX_Q96KG9	N-terminal kinase-like protein	808	89631	5.93	0	Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Centrosome;cis-Golgi network;Cytosol;Nucleus	Spinocerebellar ataxia, autosomal recessive, 21	Acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.;Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). Has no detectable kinase activity in vitro (PubMed:18556652).	NA	Belongs to the protein kinase superfamily.	NA	PE1	11
+NX_Q96KH6	Uncharacterized protein C18orf12	178	19680	6.12	0	NA	NA	NA	NA	NA	NA	PE2	18
+NX_Q96KJ4	Mesothelin-like protein	702	74540	6.71	1	Membrane	NA	May play a role in cellular adhesion.	NA	Belongs to the mesothelin family.	NA	PE2	16
+NX_Q96KJ9	Cytochrome c oxidase subunit 4 isoform 2, mitochondrial	171	20010	9.65	0	Mitochondrion inner membrane	Exocrine pancreatic insufficiency dyserythropoietic anemia and calvarial hyperostosis	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	NA	Belongs to the cytochrome c oxidase IV family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease	PE1	20
+NX_Q96KK3	Potassium voltage-gated channel subfamily S member 1	526	58372	6.71	6	Cell membrane	NA	Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:10484328).	NA	Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.	Voltage gated Potassium channels	PE1	20
+NX_Q96KK4	Olfactory receptor 10C1	312	34384	8.64	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_Q96KK5	Histone H2A type 1-H	128	13906	10.88	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Deiminated on Arg-4 in granulocytes upon calcium entry.;Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).;Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.	Belongs to the histone H2A family.	Systemic lupus erythematosus;RMTs methylate histone arginines;HATs acetylate histones;HDACs deacetylate histones;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs	PE1	6
+NX_Q96KM6	Zinc finger protein 512B	892	97264	9.87	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	20
+NX_Q96KN1	Protein LRATD2	310	34474	5.34	0	Nucleoplasm	NA	NA	NA	Belongs to the LRATD family.	NA	PE1	8
+NX_Q96KN2	Beta-Ala-His dipeptidase	507	56706	5.14	0	Secreted	NA	NA	NA	Belongs to the peptidase M20A family.	Arginine and proline metabolism;Histidine metabolism;beta-Alanine metabolism;Metabolic pathways	PE1	18
+NX_Q96KN3	Homeobox protein PKNOX2	472	52028	4.76	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	NA	NA	Belongs to the TALE/MEIS homeobox family.	NA	PE1	11
+NX_Q96KN4	Protein LRATD1	292	32491	5.46	0	Nucleoplasm;Cytoplasm	NA	May play a role in cell morphology and motility.	NA	Belongs to the LRATD family.	NA	PE1	2
+NX_Q96KN7	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1	1286	146682	5.47	0	Cilium	Cone-rod dystrophy 13;Leber congenital amaurosis 6	May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells.	NA	Belongs to the RPGRIP1 family.	NA	PE1	14
+NX_Q96KN8	Phospholipase A and acyltransferase 5	279	30312	8.33	0	Cell membrane	NA	Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:22825852). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777, PubMed:22825852).	NA	Belongs to the H-rev107 family.	Acyl chain remodelling of PE	PE1	11
+NX_Q96KN9	Gap junction delta-4 protein	370	40140	9.26	4	Gap junction;Cell membrane	NA	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Delta-type subfamily.	Gap junction assembly	PE2	10
+NX_Q96KP1	Exocyst complex component 2	924	104066	6.46	0	Cytoplasmic vesicle;Midbody ring	NA	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	NA	Belongs to the SEC5 family.	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium	PE1	6
+NX_Q96KP4	Cytosolic non-specific dipeptidase	475	52878	5.66	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568).;May play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).	NA	Belongs to the peptidase M20A family.	Arginine and proline metabolism;Histidine metabolism;beta-Alanine metabolism;Metabolic pathways;Glutathione synthesis and recycling	PE1	18
+NX_Q96KP6	TNFAIP3-interacting protein 3	325	38943	7.56	0	NA	NA	Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.	NA	NA	Ovarian tumor domain proteases	PE1	4
+NX_Q96KQ4	Apoptosis-stimulating of p53 protein 1	1090	119565	6.33	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.	PPP1R13B is phosphorylated by LATS2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the ASPP family.	Activation of PUMA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of Death Receptors and Ligands;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Regulation of TP53 Activity through Association with Co-factors	PE1	14
+NX_Q96KQ7	Histone-lysine N-methyltransferase EHMT2	1210	132370	5.3	0	Nucleoplasm;Nucleus speckle;Nucleus;Chromosome	NA	Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.	Methylated at Lys-185; automethylated.	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	Lysine degradation;PKMTs methylate histone lysines;RNA Polymerase I Transcription Initiation;Senescence-Associated Secretory Phenotype (SASP);ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Methylation;Transcriptional Regulation by E2F6	PE1	6
+NX_Q96KR1	Zinc finger RNA-binding protein	1074	117012	9.17	0	Cytoplasm;Chromosome;Nucleoplasm;Cytoplasmic granule;Nucleus	NA	Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity).	NA	NA	NA	PE1	5
+NX_Q96KR4	Leishmanolysin-like peptidase	655	73568	6.5	0	Cytoplasm;Cytosol;Focal adhesion;Lipid droplet	NA	Metalloprotease.	NA	Belongs to the peptidase M8 family.	NA	PE1	3
+NX_Q96KR6	Protein FAM210B, mitochondrial	192	20424	10.45	2	Mitochondrion outer membrane;Cytosol;Mitochondrion;Cell membrane	NA	Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398).	NA	Belongs to the FAM210 family.	NA	PE1	20
+NX_Q96KR7	Phosphatase and actin regulator 3	559	62552	9.27	0	Nucleoplasm;Nucleus matrix	NA	NA	NA	Belongs to the phosphatase and actin regulator family.	NA	PE1	20
+NX_Q96KS0	Egl nine homolog 2	407	43650	8.18	0	Nucleoplasm;Nucleus	NA	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferentially recognized via a LXXLAP motif.	NA	NA	Pathways in cancer;Renal cell carcinoma;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	PE1	19
+NX_Q96KS9	Protein FAM167A	214	24182	5.93	0	Mitochondrion	NA	NA	NA	Belongs to the FAM167 (SEC) family.	NA	PE1	8
+NX_Q96KT0	Uncharacterized protein FAM167A-AS1	104	11632	9.8	0	NA	NA	NA	NA	NA	NA	PE4	8
+NX_Q96KT6	Putative uncharacterized protein encoded by LINC00208	92	9816	8.81	0	NA	NA	NA	NA	NA	NA	PE5	8
+NX_Q96KT7	Solute carrier family 35 member G5	338	35161	6.68	9	Membrane	NA	NA	NA	Belongs to the SLC35G solute transporter family.	NA	PE2	8
+NX_Q96KV6	Putative butyrophilin subfamily 2 member A3	586	65713	5.48	1	Membrane	NA	NA	NA	Belongs to the immunoglobulin superfamily. BTN/MOG family.	NA	PE5	6
+NX_Q96KV7	WD repeat-containing protein 90	1748	187437	6.56	0	Nucleus speckle;Centriole	NA	Required for efficient primary cilium formation.	NA	Belongs to the WD repeat WDR90/POC16 family.	NA	PE1	16
+NX_Q96KW2	POM121-like protein 2	1035	109912	9.92	0	NA	NA	NA	NA	Belongs to the POM121 family.	NA	PE1	6
+NX_Q96KW9	Sperm acrosome-associated protein 7	195	21466	4.71	0	Secreted;Acrosome lumen;Acrosome	NA	Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion.	NA	NA	NA	PE1	13
+NX_Q96KX0	Lysozyme-like protein 4	146	16433	8.6	0	Acrosome;Secreted;Flagellum	NA	May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity).	NA	Belongs to the glycosyl hydrolase 22 family.	NA	PE1	3
+NX_Q96KX1	Uncharacterized protein C4orf36	117	13276	9.54	0	Focal adhesion	NA	NA	NA	NA	NA	PE2	4
+NX_Q96KX2	F-actin-capping protein subunit alpha-3	299	35025	7.61	0	NA	NA	F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).	NA	Belongs to the F-actin-capping protein alpha subunit family.	MHC class II antigen presentation;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	12
+NX_Q96L03	Spermatogenesis-associated protein 17	361	43499	9.87	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	1
+NX_Q96L08	Sushi domain-containing protein 3	255	27119	10.24	1	Nucleoplasm;Cell membrane	NA	May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration.	NA	NA	NA	PE1	9
+NX_Q96L11	LLLL and CFNLAS motif-containing protein 1	122	13527	5.89	0	Secreted	NA	NA	NA	NA	NA	PE2	7
+NX_Q96L12	Calreticulin-3	384	44996	6.19	0	Endoplasmic reticulum lumen	NA	During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.	NA	Belongs to the calreticulin family.	NA	PE1	19
+NX_Q96L14	Cep170-like protein	293	32648	5.45	0	NA	NA	NA	NA	Belongs to the CEP170 family.	NA	PE5	4
+NX_Q96L15	Ecto-ADP-ribosyltransferase 5	291	32054	8.52	0	Secreted	NA	NA	NA	Belongs to the Arg-specific ADP-ribosyltransferase family.	NA	PE1	11
+NX_Q96L21	60S ribosomal protein L10-like	214	24519	10.03	0	Nucleus	NA	May play a role in compensating for the inactivated X-linked gene during spermatogenesis.	NA	Belongs to the universal ribosomal protein uL16 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	14
+NX_Q96L33	Rho-related GTP-binding protein RhoV	236	26217	8.36	0	Cell membrane;Endosome membrane	NA	Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.	NA	Belongs to the small GTPase superfamily. Rho family.	Rho GTPase cycle	PE1	15
+NX_Q96L34	MAP/microtubule affinity-regulating kinase 4	752	82520	9.7	0	Cytoplasm;Microtubule organizing center;Cilium basal body;Centrosome;Cilium axoneme;Cytosol;Dendrite	NA	Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).	Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.;Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552). Phosphorylated throughout the cell cycle (PubMed:25123532).	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	Anchoring of the basal body to the plasma membrane	PE1	19
+NX_Q96L42	Potassium voltage-gated channel subfamily H member 8	1107	123804	6.46	6	Membrane;Cell membrane	NA	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.	NA	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.	Voltage gated Potassium channels	PE1	3
+NX_Q96L46	Calpain small subunit 2	248	27660	5.51	0	Cytoplasm;Cytosol;Cell membrane	NA	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.	NA	NA	Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	PE1	16
+NX_Q96L50	Leucine-rich repeat protein 1	414	46723	9.27	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus membrane	NA	May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	14
+NX_Q96L58	Beta-1,3-galactosyltransferase 6	329	37138	9.72	1	Golgi stack membrane	Ehlers-Danlos syndrome, spondylodysplastic type, 2;Spondyloepimetaphyseal dysplasia with joint laxity, 1, with or without fractures	Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues.	NA	Belongs to the glycosyltransferase 31 family.	Glycan metabolism; heparan sulfate biosynthesis.;Glycan metabolism; chondroitin sulfate biosynthesis.;Glycosaminoglycan biosynthesis - chondroitin sulfate;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;A tetrasaccharide linker sequence is required for GAG synthesis;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	1
+NX_Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	2696	296652	8.4	0	Nucleoplasm;Chromosome;Nucleus;Cell membrane	Beckwith-Wiedemann syndrome;Sotos syndrome 1	Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	Lysine degradation;PKMTs methylate histone lysines	PE1	5
+NX_Q96L91	E1A-binding protein p400	3159	343489	9.27	0	Nucleoplasm;Nucleus	NA	Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.	NA	Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.	HATs acetylate histones;Formation of Senescence-Associated Heterochromatin Foci (SAHF);DNA Damage/Telomere Stress Induced Senescence	PE1	12
+NX_Q96L92	Sorting nexin-27	541	61265	6.06	0	Early endosome membrane;Nucleoplasm;Cytosol	NA	Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.	NA	Belongs to the sorting nexin family.	NA	PE1	1
+NX_Q96L93	Kinesin-like protein KIF16B	1317	152011	5.86	0	Early endosome membrane;Mitochondrion;Cytoskeleton	NA	Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	20
+NX_Q96L94	Sorting nexin-22	193	22068	9.6	0	Cytoplasmic vesicle membrane;Nucleoplasm;Cytoplasmic vesicle	NA	May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).	NA	Belongs to the sorting nexin family.	NA	PE1	15
+NX_Q96L96	Alpha-protein kinase 3	1907	201272	7.73	0	Nucleoplasm;Nucleus	Cardiomyopathy, familial hypertrophic 27	Involved in cardiomyocyte differentiation.	NA	Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.	NA	PE1	15
+NX_Q96LA5	Fc receptor-like protein 2	508	55542	5.98	1	Cell membrane	NA	May have an regulatory role in normal and neoplastic B cell development.	Is N- and O-glycosylated, and phosphorylated.	NA	NA	PE1	1
+NX_Q96LA6	Fc receptor-like protein 1	429	46936	5.32	1	Cell membrane	NA	May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.	Phosphorylated on tyrosines upon activation.	NA	NA	PE1	1
+NX_Q96LA8	Protein arginine N-methyltransferase 6	375	41938	5.32	0	Nucleoplasm;Nucleolus;Nucleus	NA	Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869). Methylates HMGA1 (PubMed:16157300, PubMed:16159886). Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity).	Automethylation enhances its stability and antiretroviral activity.	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily.	RMTs methylate histone arginines;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	1
+NX_Q96LA9	Mas-related G-protein coupled receptor member X4	322	36461	9	7	Cell membrane	NA	Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.	NA	PE2	11
+NX_Q96LB0	Mas-related G-protein coupled receptor member X3	322	36483	8.79	7	Cell membrane	NA	Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.	NA	PE2	11
+NX_Q96LB1	Mas-related G-protein coupled receptor member X2	330	37099	8.36	7	Cell membrane	NA	Mast cell-specific receptor for basic secretagogues, i.e. Cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.	NA	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.	NA	PE1	11
+NX_Q96LB2	Mas-related G-protein coupled receptor member X1	322	36250	7.5	7	Cell membrane	NA	Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.	NA	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.	NA	PE1	11
+NX_Q96LB3	Intraflagellar transport protein 74 homolog	600	69239	5.73	0	Golgi apparatus;Cilium;Cytoplasmic vesicle	Bardet-Biedl syndrome 20	Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.	NA	Belongs to the IFT74 family.	Intraflagellar transport	PE1	9
+NX_Q96LB4	V-type proton ATPase subunit G 3	118	13917	9.16	0	NA	NA	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	NA	Belongs to the V-ATPase G subunit family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	1
+NX_Q96LB8	Peptidoglycan recognition protein 4	373	40620	7.2	0	Cytoplasmic vesicle;Secreted;Cell membrane	NA	Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.	N-glycosylated.	Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.	Antimicrobial peptides	PE1	1
+NX_Q96LB9	Peptidoglycan recognition protein 3	341	37611	6.48	0	Secreted	NA	Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.	N-glycosylated.	Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.	Antimicrobial peptides	PE1	1
+NX_Q96LC7	Sialic acid-binding Ig-like lectin 10	697	76592	8.69	1	Cytosol;Secreted;Cytoskeleton;Cell membrane	NA	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).	Phosphorylation of Tyr-667 is involved in binding to PTPN6.	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q96LC9	Bcl-2-modifying factor	184	20508	4.91	0	Nucleoplasm	NA	May play a role in apoptosis.;Seems to be the main initiator.	BMF is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the Bcl-2 family.	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Activation of BMF and translocation to mitochondria	PE1	15
+NX_Q96LD1	Zeta-sarcoglycan	299	32949	7.59	1	Sarcolemma;Cytoskeleton	NA	Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity).	NA	Belongs to the sarcoglycan beta/delta/gamma/zeta family.	NA	PE1	8
+NX_Q96LD4	E3 ubiquitin-protein ligase TRIM47	638	69532	6.03	0	Cytoplasm;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD.	NA	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.	PE1	17
+NX_Q96LD8	Sentrin-specific protease 8	212	24107	5.6	0	Nucleoplasm;Cytoplasmic vesicle	NA	Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.	NA	Belongs to the peptidase C48 family.	UCH proteinases;Neddylation	PE1	15
+NX_Q96LI5	CCR4-NOT transcription complex subunit 6-like	555	63001	6.26	0	Cytoplasm;Cytosol;Nucleus	NA	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.	NA	Belongs to the CCR4/nocturin family.	RNA degradation;Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	4
+NX_Q96LI6	Heat shock transcription factor, Y-linked	401	45107	6.68	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the HSF family.	NA	PE1	Y
+NX_Q96LI9	Putative uncharacterized protein CXorf58	332	38899	10.19	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_Q96LJ7	Dehydrogenase/reductase SDR family member 1	313	33909	8.01	0	Endoplasmic reticulum;Nucleoplasm;Centrosome;Cytosol	NA	NA	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	NA	PE1	14
+NX_Q96LJ8	UBX domain-containing protein 10	280	30811	8.87	0	Cilium	NA	VCP/p97-binding protein required for ciliogenesis (PubMed:26389662). Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia (PubMed:26389662). UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 (PubMed:26389662).	NA	Belongs to the UBXN10 family.	NA	PE1	1
+NX_Q96LK0	Centrosomal protein of 19 kDa	163	19166	5.24	0	Spindle pole;Centrosome;Cilium basal body;Centriole	Morbid obesity and spermatogenic failure	Required for ciliation (PubMed:28625565, PubMed:28428259, PubMed:28659385). Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28625565, PubMed:28428259). Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes (PubMed:28659385).	NA	Belongs to the CEP19 family.	NA	PE1	3
+NX_Q96LK8	Spermatogenesis-associated protein 32	384	42325	4.7	0	NA	NA	NA	NA	NA	NA	PE1	17
+NX_Q96LL3	Uncharacterized protein C16orf92	132	14383	9.23	1	Membrane	NA	NA	NA	NA	NA	PE2	16
+NX_Q96LL4	Uncharacterized protein C8orf48	319	36790	8.84	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	8
+NX_Q96LL9	DnaJ homolog subfamily C member 30, mitochondrial	226	25961	10.49	1	Mitochondrion inner membrane	NA	Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity).	NA	NA	NA	PE1	7
+NX_Q96LM1	Putative uncharacterized protein encoded by LINC00615	132	14531	9.93	0	NA	NA	NA	NA	NA	NA	PE5	12
+NX_Q96LM5	Uncharacterized protein C4orf45	186	21723	9.97	0	NA	NA	NA	NA	NA	NA	PE1	4
+NX_Q96LM6	Testis-expressed sequence 37 protein	180	20615	7.14	0	Cytoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	2
+NX_Q96LM9	Uncharacterized protein C20orf173	149	16552	6.25	0	NA	NA	NA	NA	NA	NA	PE2	20
+NX_Q96LP2	Protein FAM81B	452	52032	9.15	0	NA	NA	NA	NA	Belongs to the FAM81 family.	NA	PE1	5
+NX_Q96LP6	Uncharacterized protein C12orf42	360	39738	9.69	0	NA	NA	NA	NA	NA	NA	PE2	12
+NX_Q96LQ0	Protein phosphatase 1 regulatory subunit 36	422	49440	9.41	0	NA	NA	Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.	NA	NA	NA	PE1	14
+NX_Q96LR2	Leucine rich adaptor protein 1	239	25806	4.74	0	Cytoplasmic vesicle;Cytosol;Cytoplasm	NA	Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).	NA	NA	NA	PE1	1
+NX_Q96LR4	Chemokine-like protein TAFA-4	140	15682	9.24	0	Secreted	NA	Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release (PubMed:25109685).	NA	Belongs to the TAFA family.	NA	PE1	3
+NX_Q96LR5	Ubiquitin-conjugating enzyme E2 E2	201	22255	7.59	0	Nucleoplasm	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.	Autoubiquitinated in vitro.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	3
+NX_Q96LR7	Uncharacterized protein C2orf50	162	17838	9.51	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q96LR9	Apolipoprotein L domain-containing protein 1	279	30546	10.45	3	Nucleoplasm;Cytosol;Cell membrane	NA	May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.	NA	Belongs to the apolipoprotein L family.	NA	PE2	12
+NX_Q96LS8	Uncharacterized protein C2orf48	159	17367	9.49	0	NA	NA	NA	NA	NA	NA	PE2	2
+NX_Q96LT4	Sphingomyelin synthase-related protein 1	415	48321	8.35	6	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.	NA	Belongs to the sphingomyelin synthase family.	Sphingolipid de novo biosynthesis	PE1	10
+NX_Q96LT6	UPF0739 protein C1orf74	269	29561	5.41	0	Cytosol;Cell membrane	NA	NA	NA	Belongs to the UPF0739 family.	NA	PE1	1
+NX_Q96LT7	Guanine nucleotide exchange C9orf72	481	54328	5.82	0	Cytoplasm;Stress granule;Perikaryon;Growth cone;Secreted;Nucleus membrane;Endosome;Autophagosome;P-body;Lysosome;Axon;Dendrite;Nucleus	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Regulates stress granule assembly in response to cellular stress.;Does not play a role in regulation of stress granule assembly in response to cellular stress.;Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity (PubMed:27617292). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ATG1/ULK1 kinase complex to the phagophore which leads to autophagosome formation (PubMed:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131). Plays a role in endosomal trafficking (PubMed:24549040). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity).	NA	NA	NA	PE1	9
+NX_Q96LT9	RNA-binding region-containing protein 3	517	58575	7.61	0	Nucleoplasm;Nucleus	Growth hormone deficiency, isolated, 5	Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.	NA	NA	mRNA Splicing - Minor Pathway	PE1	1
+NX_Q96LU5	Mitochondrial inner membrane protease subunit 1	166	18504	8.29	0	Mitochondrion inner membrane	NA	Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.	NA	Belongs to the peptidase S26 family. IMP1 subfamily.	Protein export	PE1	11
+NX_Q96LU7	Myelin regulatory factor-like protein	910	101670	6.4	1	Membrane;Nucleolus	NA	NA	NA	Belongs to the MRF family.	NA	PE2	12
+NX_Q96LW1	Zinc finger protein 354B	612	70529	9.6	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	5
+NX_Q96LW2	Ribosomal protein S6 kinase-related protein	410	46191	6.87	0	Cytoplasmic vesicle;Nucleoplasm;Cell membrane	NA	NA	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE2	17
+NX_Q96LW4	DNA-directed primase/polymerase protein	560	64412	5.19	0	Cytoplasm;Mitochondrion matrix;Nucleoplasm;Cytosol;Nucleus	Myopia 22, autosomal dominant	DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH.	NA	Belongs to the eukaryotic-type primase small subunit family.	NA	PE1	4
+NX_Q96LW7	Caspase recruitment domain-containing protein 19	228	25589	9.43	0	Mitochondrion membrane;Endoplasmic reticulum membrane;Nucleus;Mitochondrion	NA	Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.	NA	NA	NA	PE1	9
+NX_Q96LW9	Zinc finger and SCAN domain-containing protein 31	406	47293	6.42	0	Nucleoplasm;Cytosol;Nucleus	NA	May function as a transcription factor. May be involved in the development of multiple embryonic organs.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_Q96LX7	Coiled-coil domain-containing protein 17	622	67721	6.76	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q96LX8	Zinc finger protein 597	424	48076	6.29	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_Q96LY2	Coiled-coil domain-containing protein 74B	380	41826	10.46	0	NA	NA	NA	NA	NA	NA	PE2	2
+NX_Q96LZ2	Melanoma-associated antigen B10	347	38971	5.74	0	NA	NA	NA	NA	NA	NA	PE1	X
+NX_Q96LZ3	Calcineurin subunit B type 2	170	19533	4.73	0	NA	NA	Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.	NA	Belongs to the calcineurin regulatory subunit family.	MAPK signaling pathway;Calcium signaling pathway;Oocyte meiosis;Apoptosis;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Long-term potentiation;Glutamatergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Tuberculosis	PE1	9
+NX_Q96LZ7	Regulator of microtubule dynamics protein 2	410	47399	6.12	1	Golgi apparatus;Cytoplasm;Membrane;Spindle pole;Cytosol;Spindle	NA	NA	NA	Belongs to the RMDN family.	NA	PE1	2
+NX_Q96M02	(E2-independent) E3 ubiquitin-conjugating enzyme FATS	699	77910	9.21	0	Cytoplasm;Cell membrane;Nucleoplasm;Centrosome;Cytosol	NA	Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable).	NA	NA	NA	PE1	10
+NX_Q96M11	Hydrolethalus syndrome protein 1	299	34359	6.98	0	Cytoplasm;Cell membrane;Centriole;Cilium;Centrosome;Cytosol	Hydrolethalus syndrome 1	Plays a role in ciliogenesis.	NA	Belongs to the HYLS1 family.	NA	PE1	11
+NX_Q96M15	Putative uncharacterized protein IGF2BP2-AS1	143	15995	9.42	0	NA	NA	NA	NA	NA	NA	PE2	3
+NX_Q96M19	Putative transmembrane protein encoded by LINC00477	166	18185	10.52	3	Membrane	NA	NA	NA	NA	NA	PE5	12
+NX_Q96M20	Cyclic nucleotide-binding domain-containing protein 2	576	67512	9.33	0	Cytosol	NA	Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.	NA	NA	NA	PE1	20
+NX_Q96M27	Protein PRRC1	445	46701	5.56	0	Golgi apparatus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the PRRC1 family.	NA	PE1	5
+NX_Q96M29	Tektin-5	485	56294	6.8	0	Cytoskeleton;Flagellum	NA	May be a structural component of the sperm flagellum.	NA	Belongs to the tektin family.	NA	PE1	16
+NX_Q96M32	Adenylate kinase 7	723	82658	4.67	0	Cytosol;Flagellum	Spermatogenic failure 27	Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.	NA	In the central section; belongs to the adenylate kinase family.;In the C-terminal section; belongs to the dpy-30 family.	Purine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	14
+NX_Q96M34	Testis-specific expressed protein 55	536	60162	5.51	0	Nucleus	NA	NA	NA	NA	NA	PE1	3
+NX_Q96M42	Putative uncharacterized protein encoded by LINC00479	142	15208	8.28	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_Q96M43	Neuroblastoma breakpoint family member 4	638	72053	4.83	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE2	1
+NX_Q96M53	Protein TBATA	351	39460	9.21	0	Cytosol	NA	May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function.	NA	Belongs to the TBATA family.	NA	PE2	10
+NX_Q96M60	Protein FAM227B	508	59956	9	0	Nucleus speckle	NA	NA	NA	Belongs to the FAM227 family.	NA	PE1	15
+NX_Q96M61	Melanoma-associated antigen B18	343	38533	6.81	0	Cytoplasm	NA	May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.	NA	NA	NA	PE1	X
+NX_Q96M63	Coiled-coil domain-containing protein 114	670	75046	5.87	0	Cilium	Ciliary dyskinesia, primary, 20	Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms.	NA	Belongs to the ODA1/DCC2 family.	NA	PE1	19
+NX_Q96M66	Putative uncharacterized protein FLJ32790	194	20693	9.73	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_Q96M69	Leucine-rich repeat and guanylate kinase domain-containing protein	825	93618	6	0	Acrosome;Cilium basal body;Cytoskeleton	NA	Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis.	NA	NA	NA	PE1	7
+NX_Q96M78	Putative uncharacterized protein encoded by FER1L6-AS2	137	15528	6.44	0	NA	NA	NA	NA	NA	NA	PE2	8
+NX_Q96M83	Coiled-coil domain-containing protein 7	1385	157448	7.16	0	Cytosol;Spindle;Nucleolus	NA	May play a role in tumorigenesis.	NA	NA	NA	PE1	10
+NX_Q96M85	Putative uncharacterized protein FLJ32756	177	19601	9.71	0	NA	NA	NA	NA	NA	NA	PE2	22
+NX_Q96M86	Dynein heavy chain domain-containing protein 1	4753	533644	6.25	0	Nucleoplasm;Cytoskeleton	NA	NA	NA	Belongs to the dynein heavy chain family.	NA	PE1	11
+NX_Q96M89	Coiled-coil domain-containing protein 138	665	76219	8.75	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	2
+NX_Q96M91	Cilia- and flagella-associated protein 53	514	61835	9	0	Cilium;Midbody	Heterotaxy, visceral, 6, autosomal	May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.	NA	Belongs to the CFAP53 family.	NA	PE1	18
+NX_Q96M93	Adenosine deaminase domain-containing protein 1	576	64411	9.14	0	Nucleus	NA	Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity).	NA	Belongs to the ADAD family.	NA	PE1	4
+NX_Q96M94	Kelch-like protein 15	604	69775	5.98	0	Cytosol;Nucleus	Mental retardation, X-linked 103	Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:14528312). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354).	NA	NA	Protein modification; protein ubiquitination.	PE1	X
+NX_Q96M95	Coiled-coil domain-containing protein 42	316	38019	9.18	0	NA	NA	Required for sperm development.	NA	Belongs to the CFAP73 family.	NA	PE1	17
+NX_Q96M96	FYVE, RhoGEF and PH domain-containing protein 4	766	86626	5.8	0	Filopodium;Cytoskeleton	Charcot-Marie-Tooth disease 4H	Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity).	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	12
+NX_Q96M98	Parkin coregulated gene protein	296	33342	8.42	0	NA	NA	Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.	NA	NA	NA	PE1	6
+NX_Q96MA1	Doublesex- and mab-3-related transcription factor B1	342	36205	6.6	0	Nucleus	NA	NA	NA	Belongs to the DMRT family.	NA	PE1	1
+NX_Q96MA6	Adenylate kinase 8	479	54926	5.77	0	Cytosol	NA	Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.	NA	Belongs to the adenylate kinase family.	Interconversion of nucleotide di- and triphosphates	PE1	9
+NX_Q96MB7	Putative nuclease HARBI1	349	39146	5.28	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	NA	Belongs to the HARBI1 family.	NA	PE1	11
+NX_Q96MC2	Dynein regulatory complex protein 1	740	87134	5.3	0	Flagellum axoneme;Cilium axoneme	Ciliary dyskinesia, primary, 21	Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23354437).	NA	Belongs to the DRC1 family.	NA	PE1	2
+NX_Q96MC4	CEP295 N-terminal-like protein	621	69839	9.65	0	Cytoplasmic vesicle;Cilium	NA	NA	NA	NA	NA	PE1	17
+NX_Q96MC5	bMERB domain-containing protein 1	204	23732	5.93	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	16
+NX_Q96MC6	Hippocampus abundant transcript 1 protein	490	53027	8.63	12	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE1	1
+NX_Q96MC9	Uncharacterized protein C1orf147	270	29841	10.45	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q96MD2	KICSTOR complex protein C12orf66	445	50415	8.95	0	Lysosome membrane;Lysosome;Cytoskeleton	NA	As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	NA	Belongs to the UPF0536 family.	NA	PE1	12
+NX_Q96MD7	Uncharacterized protein C9orf85	179	20166	9.54	0	Golgi apparatus;Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	9
+NX_Q96ME1	F-box/LRR-repeat protein 18	805	88341	8.73	0	Nucleoplasm;Cytosol	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation	PE1	7
+NX_Q96ME7	Zinc finger protein 512	567	64682	9.8	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	2
+NX_Q96MF0	Putative uncharacterized protein LOC100506887	132	14640	8.82	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_Q96MF2	SH3 and cysteine-rich domain-containing protein 3	364	41507	6.5	0	Cytoplasm;T-tubule;Nucleoplasm;Cytosol;Sarcolemma	Myopathy, congenital, Bailey-Bloch	Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335). Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335).	NA	NA	NA	PE1	12
+NX_Q96MF4	Coiled-coil domain-containing protein 140	163	18252	10.64	0	NA	NA	NA	NA	NA	NA	PE1	2
+NX_Q96MF6	Coenzyme Q-binding protein COQ10 homolog A, mitochondrial	247	27686	9.81	0	Endoplasmic reticulum;Golgi apparatus;Cytosol;Mitochondrion inner membrane	NA	Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable).	NA	Belongs to the COQ10 family.	Respiratory electron transport	PE1	12
+NX_Q96MF7	E3 SUMO-protein ligase NSE2	247	27932	7.62	0	Nucleoplasm;Nucleus;Telomere;PML body	Seckel syndrome 10	E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.	Sumoylated, possibly via autosumoylation.	Belongs to the NSE2 family.	Protein modification; protein sumoylation.;SUMOylation of DNA damage response and repair proteins	PE1	8
+NX_Q96MG2	Junctional sarcoplasmic reticulum protein 1	331	36319	9.43	0	Endoplasmic reticulum;Endoplasmic reticulum membrane;Sarcoplasmic reticulum membrane	NA	Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity.	NA	NA	NA	PE1	19
+NX_Q96MG7	Non-structural maintenance of chromosomes element 3 homolog	304	34308	9.3	0	Cytoplasm;Telomere;Nucleus	Lung disease, immunodeficiency, and chromosome breakage syndrome	Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity).	NA	NA	SUMOylation of DNA damage response and repair proteins	PE1	15
+NX_Q96MG8	Protein-L-isoaspartate O-methyltransferase domain-containing protein 1	357	40675	5.46	0	Membrane;Nucleoplasm;Cytoplasm;Cell membrane	NA	NA	NA	Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.	NA	PE1	8
+NX_Q96MH2	Protein HEXIM2	286	32419	6.13	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.	NA	Belongs to the HEXIM family.	NA	PE1	17
+NX_Q96MH6	Transmembrane protein 68	324	37425	7.72	2	Membrane;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	8
+NX_Q96MH7	Uncharacterized protein C5orf34	638	72898	8.16	0	NA	NA	NA	NA	NA	NA	PE1	5
+NX_Q96MI6	Protein phosphatase 1M	270	30375	5.34	0	Nucleus	NA	NA	NA	Belongs to the PP2C family.	NA	PE1	3
+NX_Q96MI9	Cytosolic carboxypeptidase 4	1112	125330	6.71	0	Cytosol	Corneal dystrophy, Fuchs endothelial, 8	Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.	NA	Belongs to the peptidase M14 family.	Carboxyterminal post-translational modifications of tubulin	PE1	15
+NX_Q96MK2	RIPOR family member 3	946	105290	7.26	0	Nucleoplasm	NA	NA	NA	Belongs to the RIPOR family.	NA	PE1	20
+NX_Q96MK3	Pseudokinase FAM20A	541	61417	8.2	0	Golgi apparatus;Endoplasmic reticulum;Secreted	Amelogenesis imperfecta 1G	Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.	N-glycosylated.	Belongs to the FAM20 family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	17
+NX_Q96MM3	Zinc finger protein 42 homolog	310	34802	9.12	0	Nucleus	NA	Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).	Polyubiquitinated by RNF12, leading to proteasomal degradation.	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	4
+NX_Q96MM6	Heat shock 70 kDa protein 12B	686	75688	8.81	0	Nucleoplasm	NA	NA	NA	Belongs to the heat shock protein 70 family.	Regulation of HSF1-mediated heat shock response	PE1	20
+NX_Q96MM7	Heparan-sulfate 6-O-sulfotransferase 2	605	69130	9.79	1	Membrane;Nucleoplasm	Paganini-Miozzo syndrome	6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.	NA	Belongs to the sulfotransferase 6 family.	Glycosaminoglycan biosynthesis - heparan sulfate;HS-GAG biosynthesis	PE1	X
+NX_Q96MN2	NACHT, LRR and PYD domains-containing protein 4	994	113415	5.54	0	Mitochondrion	NA	May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.	NA	Belongs to the NLRP family.	Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN;IRF3 mediated activation of type 1 IFN	PE1	19
+NX_Q96MN5	Transcription elongation factor A N-terminal and central domain-containing protein 2	208	24150	10.05	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the TCEANC2 family.	NA	PE1	1
+NX_Q96MN9	Zinc finger protein 488	340	36962	9.2	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	10
+NX_Q96MP5	Zinc finger SWIM domain-containing protein 3	696	79454	7.27	0	Cytoplasmic vesicle;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	20
+NX_Q96MP8	BTB/POZ domain-containing protein KCTD7	289	33132	5.58	0	Cytosol;Cell membrane	Epilepsy, progressive myoclonic 3, with or without intracellular inclusions	May be involved in the control of excitability of cortical neurons.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	7
+NX_Q96MR6	Cilia- and flagella-associated protein 57	1250	144961	5.61	0	Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q96MR7	Putative uncharacterized protein OBSCN-AS1	158	17524	11.82	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q96MR9	Zinc finger protein 560	790	91121	8.99	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q96MS0	Roundabout homolog 3	1386	148209	6.74	1	Membrane;Cytoplasmic vesicle;Cell membrane	Gaze palsy, familial horizontal, with progressive scoliosis, 1	Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube (By similarity). In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing (PubMed:15105459).	NA	Belongs to the immunoglobulin superfamily. ROBO family.	Axon guidance;Regulation of commissural axon pathfinding by SLIT and ROBO;Regulation of expression of SLITs and ROBOs;ROBO receptors bind AKAP5	PE1	11
+NX_Q96MS3	Glycosyltransferase 1 domain-containing protein 1	346	38507	6.02	0	Cytosol;Secreted	NA	NA	NA	Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.	NA	PE1	12
+NX_Q96MT0	Putative uncharacterized protein FLJ31958	163	16963	5.29	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_Q96MT1	RING finger protein 145	663	75617	6.39	14	Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Nucleoplasm;Cytosol	NA	E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately downregulating cholesterol biosynthesis.	NA	NA	NA	PE1	5
+NX_Q96MT3	Prickle-like protein 1	831	94300	5.84	0	Nucleoplasm;Cytosol;Nucleus membrane	Neural tube defects;Epilepsy, progressive myoclonic 1B	Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.	NA	Belongs to the prickle / espinas / testin family.	Wnt signaling pathway;Asymmetric localization of PCP proteins	PE1	12
+NX_Q96MT4	Uncharacterized protein encoded by LINC01600	127	13896	7.59	0	NA	NA	NA	NA	NA	NA	PE1	6
+NX_Q96MT7	Cilia- and flagella-associated protein 44	1854	213865	5.28	0	Flagellum axoneme;Flagellum	Spermatogenic failure 20	Flagellar protein involved in sperm flagellum axoneme organization and function.	NA	Belongs to the CFAP44 family.	NA	PE1	3
+NX_Q96MT8	Centrosomal protein of 63 kDa	703	81344	5.78	0	Nucleoplasm;Centriolar satellite;Centrosome;Centriole	Seckel syndrome 6	Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398).	NA	Belongs to the CEP63 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	3
+NX_Q96MU5	Uncharacterized protein C17orf77	243	26264	6.58	0	Secreted	NA	NA	NA	NA	NA	PE2	17
+NX_Q96MU6	Zinc finger protein 778	729	81964	8.77	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_Q96MU7	YTH domain-containing protein 1	727	84700	5.87	0	Nucleoplasm;Nucleus speckle;Nucleus;Cell membrane	NA	Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity).	Tyrosine phosphorylated.;YTHDC1 is phosphorylated by ABL1 (Phosphotyrosine:PTM-0255)	NA	NA	PE1	4
+NX_Q96MU8	Kremen protein 1	473	51744	6.69	1	Nucleoplasm;Cytosol;Nucleus;Cell membrane	Ectodermal dysplasia 13, hair/tooth type	Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.	NA	NA	TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	PE1	22
+NX_Q96MV1	TLC domain-containing protein 4	263	30041	9.4	6	Membrane;Nucleus speckle	NA	NA	NA	Belongs to the TLCD4 family.	NA	PE1	1
+NX_Q96MV8	Palmitoyltransferase ZDHHC15	337	39331	8.42	4	Cytosol;Nucleus speckle;Golgi apparatus membrane	Mental retardation, X-linked 91	Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95.	Autopalmitoylated (in vitro).	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	X
+NX_Q96MW1	Coiled-coil domain-containing protein 43	224	25248	4.85	0	Cytosol	NA	NA	NA	Belongs to the CCDC43 family.	NA	PE1	17
+NX_Q96MW5	Conserved oligomeric Golgi complex subunit 8	612	68424	5.12	0	Golgi apparatus;Golgi apparatus membrane	Congenital disorder of glycosylation 2H	Required for normal Golgi function.	NA	Belongs to the COG8 family.	Intra-Golgi traffic;COPI-mediated anterograde transport;Retrograde transport at the Trans-Golgi-Network	PE1	16
+NX_Q96MW7	Tigger transposable element-derived protein 1	591	67299	8.53	0	Nucleoplasm;Nucleolus;Nucleus	NA	NA	NA	Belongs to the tigger transposable element derived protein family.	NA	PE1	2
+NX_Q96MX0	CKLF-like MARVEL transmembrane domain-containing protein 3	182	19714	4.39	3	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the chemokine-like factor family.	NA	PE1	16
+NX_Q96MX3	Zinc finger protein 48	618	67820	9.51	0	Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	16
+NX_Q96MX6	WD repeat-containing protein 92	357	39740	8.32	0	Nucleoplasm	NA	Seems to act as a modulator of apoptosis.	NA	NA	NA	PE1	2
+NX_Q96MY1	Nucleolar protein 4-like	436	47215	4.92	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	20
+NX_Q96MY7	Protein FAM161B	647	73647	9.44	0	NA	NA	NA	NA	Belongs to the FAM161 family.	NA	PE1	14
+NX_Q96MZ0	Ganglioside-induced differentiation-associated protein 1-like 1	367	41973	6.13	0	Endoplasmic reticulum	NA	NA	NA	Belongs to the GST superfamily.	NA	PE1	20
+NX_Q96MZ4	Protein FAM218A	157	17021	11.82	0	NA	NA	NA	NA	NA	NA	PE1	4
+NX_Q96N03	V-set and transmembrane domain-containing protein 2-like protein	204	22349	8.75	0	NA	NA	NA	NA	NA	NA	PE1	20
+NX_Q96N06	Spermatogenesis-associated protein 33	139	15461	9.27	0	Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	16
+NX_Q96N11	Uncharacterized protein C7orf26	449	50047	7.61	0	Nucleoplasm;Cytosol;Nucleolus;Cytoskeleton	NA	NA	NA	NA	NA	PE1	7
+NX_Q96N16	Janus kinase and microtubule-interacting protein 1	626	73209	5.84	0	Membrane;Cytoskeleton	NA	Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.	NA	Belongs to the JAKMIP family.	NA	PE1	4
+NX_Q96N19	Integral membrane protein GPR137	417	46059	8.78	7	Membrane;Nucleoplasm;Nucleolus;Cytoskeleton	NA	NA	NA	Belongs to the GPR137 family.	NA	PE1	11
+NX_Q96N20	Zinc finger protein 75A	296	34694	9.55	0	Nucleoplasm;Nucleus;Nucleolus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_Q96N21	AP-4 complex accessory subunit Tepsin	525	55137	6.57	0	Golgi apparatus;Nucleus speckle;trans-Golgi network membrane;Nucleus membrane;Cytoplasmic vesicle;Cytosol	NA	Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.	NA	NA	NA	PE1	17
+NX_Q96N22	Zinc finger protein 681	645	75059	9.27	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q96N23	Cilia- and flagella-associated protein 54	3096	351970	8.41	0	Cytosol;Cilium axoneme;Cytoskeleton	NA	Required for assembly and function of cilia and flagella.	NA	Belongs to the CFAP54 family.	NA	PE1	12
+NX_Q96N28	PRELI domain containing protein 3A	172	19247	7.02	0	Mitochondrion	NA	In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.	NA	Belongs to the slowmo family.	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	PE1	18
+NX_Q96N35	Putative uncharacterized protein encoded by LINC00052	136	15076	7.18	1	Membrane	NA	NA	NA	NA	NA	PE5	15
+NX_Q96N38	Zinc finger protein 714	554	63883	9.29	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96N46	Tetratricopeptide repeat protein 14	770	88319	8.77	0	Nucleoplasm	NA	NA	NA	Belongs to the TTC14 family.	NA	PE1	3
+NX_Q96N53	Putative uncharacterized protein encoded by LINC00167	147	15424	11.86	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q96N58	Zinc finger protein 578	590	68531	9.19	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q96N64	PWWP domain-containing protein 2A	755	81960	9.09	0	Nucleoplasm;Focal adhesion;Nucleus	NA	H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression.	NA	NA	NA	PE1	5
+NX_Q96N66	Lysophospholipid acyltransferase 7	472	52765	9.16	7	Cytosol;Endoplasmic reticulum membrane	Mental retardation, autosomal recessive 57	Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Required for cortical lamination during brain development (By similarity).	NA	Belongs to the membrane-bound acyltransferase family.	Lipid metabolism; phospholipid metabolism.;Glycerophospholipid metabolism;Acyl chain remodelling of PI	PE1	19
+NX_Q96N67	Dedicator of cytokinesis protein 7	2140	242561	6.34	0	Axon	Epileptic encephalopathy, early infantile, 23	Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).	DOCK7 is phosphorylated by ERBB2	Belongs to the DOCK family.	Factors involved in megakaryocyte development and platelet production;MET activates RAP1 and RAC1	PE1	1
+NX_Q96N68	Putative uncharacterized protein C18orf15	181	19136	7.45	1	Membrane	NA	NA	NA	NA	NA	PE5	18
+NX_Q96N76	Urocanate hydratase	676	74831	6.34	0	NA	Urocanase deficiency	NA	NA	Belongs to the urocanase family.	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.;Histidine metabolism;Metabolic pathways;Histidine catabolism	PE1	3
+NX_Q96N77	Zinc finger protein 641	438	49528	5.78	0	Nucleoplasm;Nucleus	NA	Transcriptional activator. Activates transcriptional activities of SRE and AP-1.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	12
+NX_Q96N87	Inactive sodium-dependent neutral amino acid transporter B(0)AT3	628	70897	7.03	12	Membrane;Endoplasmic reticulum	NA	Does not show neutral amino acid transporter activity.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily.	Amino acid transport across the plasma membrane;Na+/Cl- dependent neurotransmitter transporters;Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria;Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria	PE2	5
+NX_Q96N95	Zinc finger protein 396	335	38612	8.26	0	Cytoplasm;Nucleus	NA	Act as DNA-dependent transcriptional repressors.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	18
+NX_Q96N96	Spermatogenesis-associated protein 13	652	74820	7.01	0	Cytoplasm;Nucleoplasm;Lamellipodium;Filopodium;Ruffle membrane;Cytosol	NA	Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.	NA	NA	NA	PE1	13
+NX_Q96NA2	Rab-interacting lysosomal protein	401	44200	5.47	0	Phagosome membrane;Lysosome membrane;Late endosome membrane	NA	Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.	NA	NA	Phagosome;Salmonella infection;MHC class II antigen presentation	PE1	17
+NX_Q96NA8	t-SNARE domain-containing protein 1	513	55949	9.23	1	Membrane;Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	8
+NX_Q96NB1	LisH domain-containing protein FOPNL	174	19778	6.6	0	Centriole;Centriolar satellite;Cilium;Cilium basal body;Centrosome;Cytoplasmic granule	NA	Involved in the biogenesis of cilia (PubMed:20551181). Required for the recruitment of PLK1 to centrosomes and S phase progression (PubMed:24018379).	NA	Belongs to the FGFR1OP family.	NA	PE1	16
+NX_Q96NB2	Sideroflexin-2	322	36232	9.48	5	Mitochondrion membrane;Mitochondrion	NA	Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria.	NA	Belongs to the sideroflexin family.	NA	PE1	10
+NX_Q96NB3	Zinc finger protein 830	372	41999	5.22	0	Nucleoplasm;Nucleus speckle;Nucleus;Chromosome	NA	May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity).	Phosphorylated in response to DNA damage by the cell cycle checkpoint kinases ATR/ATM.	NA	Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER	PE1	17
+NX_Q96NC0	Zinc finger matrin-type protein 2	199	23612	9.08	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Involved in pre-mRNA splicing as a component of the spliceosome.	NA	NA	NA	PE1	5
+NX_Q96ND0	Protein FAM210A	272	30777	9.77	1	Golgi apparatus;Cytoplasm;Mitochondrion;Membrane;Nucleoplasm	NA	May play a role in the structure and strength of both muscle and bone.	NA	Belongs to the FAM210 family.	NA	PE1	18
+NX_Q96ND8	Zinc finger protein 583	569	66033	9.07	0	Nucleolus;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96NE9	FERM domain-containing protein 6	622	72044	7.12	0	Cytoplasm;Mitochondrion;Cell membrane	NA	NA	NA	NA	NA	PE1	14
+NX_Q96NF6	Putative uncharacterized protein C8orf49	230	25558	9.67	1	Membrane	NA	NA	NA	NA	NA	PE2	8
+NX_Q96NG3	Tetratricopeptide repeat protein 25	672	76655	5.49	0	Cytoplasm;Cilium axoneme	Ciliary dyskinesia, primary, 35	Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility.	NA	NA	NA	PE1	17
+NX_Q96NG5	Zinc finger protein 558	402	45755	9.2	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96NG8	Zinc finger protein 582	517	60498	8.79	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q96NH3	Protein broad-minded	1257	144756	6.3	0	Cytoplasm;Mitochondrion;Cilium	NA	Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity).	NA	NA	NA	PE1	6
+NX_Q96NI6	Leucine-rich repeat and fibronectin type-III domain-containing protein 5	719	79445	7.26	1	Membrane	NA	Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons.	NA	Belongs to the LRFN family.	NA	PE1	14
+NX_Q96NI8	Zinc finger protein 570	536	62330	8.63	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96NJ1	Uncharacterized protein FLJ30774	140	14269	11.49	0	NA	NA	NA	NA	NA	NA	PE2	9
+NX_Q96NJ3	Zinc finger protein 285	590	68261	8.59	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96NJ5	Kelch-like protein 32	620	70362	5.97	0	NA	NA	NA	NA	NA	NA	PE2	6
+NX_Q96NJ6	Zinc finger protein 3 homolog	502	57662	6.99	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	17
+NX_Q96NK8	Neurogenic differentiation factor 6	337	38705	8.76	0	Nucleus	NA	Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity).	NA	NA	NA	PE1	7
+NX_Q96NL0	RUN domain-containing protein 3B	473	52813	5.44	0	NA	NA	NA	NA	Belongs to the RUNDC3 family.	NA	PE1	7
+NX_Q96NL1	Transmembrane protein 74	305	33338	5.12	2	Autophagosome membrane;Cytosol;Lysosome membrane	NA	Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.	NA	Belongs to the TMEM74 family.	NA	PE1	8
+NX_Q96NL3	Zinc finger protein 599	588	67492	8.73	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96NL6	Sodium channel and clathrin linker 1	688	80910	5.83	0	Centriole	NA	Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity).	NA	NA	Anchoring of the basal body to the plasma membrane	PE1	4
+NX_Q96NL8	Protein C8orf37	207	23381	6.52	0	Cytoplasm;Cell membrane;Photoreceptor inner segment;Cell junction;Cytosol	Bardet-Biedl syndrome 21;Retinitis pigmentosa 64;Cone-rod dystrophy 16	May be involved in photoreceptor outer segment disk morphogenesis (By similarity).	NA	NA	NA	PE1	8
+NX_Q96NM4	TOX high mobility group box family member 2	488	51604	6.23	0	Nucleoplasm;Nucleus	NA	Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.	NA	NA	NA	PE1	20
+NX_Q96NN9	Apoptosis-inducing factor 3	605	66791	9.2	0	Mitochondrion	NA	Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.	NA	Belongs to the FAD-dependent oxidoreductase family.	NA	PE1	22
+NX_Q96NR2	Putative MIR1-1HG-AS1	134	14382	11.88	0	NA	NA	NA	NA	NA	NA	PE2	20
+NX_Q96NR3	Patched domain-containing protein 1	888	101341	8.57	11	Cell membrane	Autism, X-linked 4	Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention.	NA	Belongs to the patched family.	NA	PE2	X
+NX_Q96NR7	Putative uncharacterized protein WWC2-AS2	200	21356	12.28	0	NA	NA	NA	NA	NA	NA	PE5	4
+NX_Q96NR8	Retinol dehydrogenase 12	316	35094	9.73	0	Endoplasmic reticulum membrane	Leber congenital amaurosis 13;Retinitis pigmentosa 53	Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:15865448, PubMed:12226107). Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (PubMed:19686838, PubMed:15865448). May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). Has no dehydrogenase activity towards steroids (PubMed:15865448, PubMed:12226107).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Cofactor metabolism; retinol metabolism.;Retinol metabolism;Metabolic pathways;The canonical retinoid cycle in rods (twilight vision);Retinoid cycle disease events	PE1	14
+NX_Q96NS1	Protein yippee-like 4	127	14301	8.42	0	Nucleolus	NA	NA	NA	Belongs to the yippee family.	NA	PE1	11
+NX_Q96NS5	Ankyrin repeat and SOCS box protein 16	453	49637	8.39	0	Focal adhesion	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	17
+NX_Q96NS8	Putative protein CLUHP3	147	16687	6.48	0	NA	NA	NA	NA	NA	NA	PE5	16
+NX_Q96NT0	Coiled-coil domain-containing protein 115	180	19761	6.44	0	Endoplasmic reticulum-Golgi intermediate compartment;Cell membrane;Endoplasmic reticulum;Endosome;Lysosome;Cytoplasmic vesicle;COPI-coated vesicle	Congenital disorder of glycosylation 2O	Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833332).	NA	NA	NA	PE1	2
+NX_Q96NT1	Nucleosome assembly protein 1-like 5	182	19593	4.12	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	4
+NX_Q96NT3	Protein GUCD1	240	27207	6.4	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	22
+NX_Q96NT5	Proton-coupled folate transporter	459	49771	9.03	12	Cytoplasm;Apical cell membrane;Cytosol;Cell membrane	Hereditary folate malabsorption	Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.	NA	Belongs to the major facilitator superfamily. SLC46A family.	Vitamin digestion and absorption;Mineral absorption;Metabolism of folate and pterines;Iron uptake and transport	PE1	17
+NX_Q96NU0	Contactin-associated protein-like 3B	1288	140415	7.19	1	Membrane	NA	NA	NA	Belongs to the neurexin family.	NA	PE1	9
+NX_Q96NU1	Sterile alpha motif domain-containing protein 11	681	72708	7.34	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	May play a role in photoreceptor development.	NA	NA	NA	PE1	1
+NX_Q96NU7	Probable imidazolonepropionase	426	46743	6.14	0	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	Belongs to the metallo-dependent hydrolases superfamily. HutI family.	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.;Histidine metabolism;Metabolic pathways;Histidine catabolism	PE1	12
+NX_Q96NW4	Ankyrin repeat domain-containing protein 27	1050	116984	6.42	0	Cell membrane;Early endosome;Cytoplasmic vesicle membrane;Endosome;Melanosome;Late endosome;Lysosome;Cytosol	NA	May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	19
+NX_Q96NW7	Leucine-rich repeat-containing protein 7	1537	172581	6.37	0	Cytoplasm;Cell membrane;Nucleoplasm;Centrosome;Postsynaptic density;Cytosol	NA	Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.	NA	Belongs to the LAP (LRR and PDZ) protein family.	RAF/MAP kinase cascade;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;Neutrophil degranulation;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	1
+NX_Q96NX5	Calcium/calmodulin-dependent protein kinase type 1G	476	53087	7.83	0	Cytoplasm;Golgi apparatus membrane;Cell membrane	NA	Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).	May be prenylated on Cys-473.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	NA	PE1	1
+NX_Q96NX9	Dachshund homolog 2	599	65323	9.22	0	Nucleoplasm;Nucleus	NA	Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain.	NA	Belongs to the DACH/dachshund family.	NA	PE1	X
+NX_Q96NY7	Chloride intracellular channel protein 6	704	73012	4.29	1	Cytoplasm;Cell membrane	NA	May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).	Phosphorylated.	Belongs to the chloride channel CLIC family.	NA	PE1	21
+NX_Q96NY8	Nectin-4	510	55454	5.23	1	Adherens junction;Secreted;Cell membrane	Ectodermal dysplasia-syndactyly syndrome 1	(Microbial infection) Acts as a receptor for measles virus.;Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.	The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.	Belongs to the nectin family.	Adherens junction;Adherens junctions interactions;Nectin/Necl trans heterodimerization	PE1	1
+NX_Q96NY9	Crossover junction endonuclease MUS81	551	61173	9.78	0	Nucleoplasm;Nucleolus	NA	Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.	NA	Belongs to the XPF family.	Resolution of D-loop Structures through Holliday Junction Intermediates;Fanconi Anemia Pathway	PE1	11
+NX_Q96NZ1	Forkhead box protein N4	517	55215	5.93	0	Nucleoplasm;Cytosol;Mitochondrion;Nucleus	NA	Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).	NA	NA	NA	PE1	12
+NX_Q96NZ8	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1	548	58798	5.84	0	Secreted	NA	Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity).	NA	Belongs to the WFIKKN family.	NA	PE1	16
+NX_Q96NZ9	Proline-rich acidic protein 1	151	17208	5.2	0	Secreted	NA	May play an important role in maintaining normal growth homeostasis in epithelial cells.	NA	NA	NA	PE1	10
+NX_Q96P09	Baculoviral IAP repeat-containing protein 8	236	27089	6.99	0	Cytoplasm	NA	Protects against apoptosis mediated by BAX.	NA	Belongs to the IAP family.	NA	PE1	19
+NX_Q96P11	Probable 28S rRNA (cytosine-C(5))-methyltransferase	429	46692	8.91	0	NA	NA	S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	NA	PE1	7
+NX_Q96P15	Serpin B11	392	44099	8.42	0	Cytoplasm	NA	Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.	NA	Belongs to the serpin family. Ov-serpin subfamily.	NA	PE1	18
+NX_Q96P16	Regulation of nuclear pre-mRNA domain-containing protein 1A	312	35720	7.13	0	Golgi apparatus;Nucleoplasm	NA	Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.	NA	Belongs to the UPF0400 (RTT103) family.	RNA polymerase II transcribes snRNA genes	PE1	18
+NX_Q96P20	NACHT, LRR and PYD domains-containing protein 3	1036	118173	6.22	0	Inflammasome;Secreted;Endoplasmic reticulum;Golgi apparatus membrane;Cytosol;Nucleus	Deafness, autosomal dominant, 34, with or without inflammation;Muckle-Wells syndrome;Familial cold autoinflammatory syndrome 1;Chronic infantile neurologic cutaneous and articular syndrome;Keratoendothelitis fugax hereditaria	As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu (PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. However, it is unclear what constitutes the direct NLRP3 activator. Activation in presence of cytosolic dsRNA is mediated by DHX33 (PubMed:23871209). Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity).	The disulfide bond in the pyrin domain might play a role in reactive oxygen species-mediated activation.;Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Ubiquitination does not lead to degradation, but inhibits inflammasome activation (By similarity). Deubiquitination is catalyzed by BRCC3 and associated with NLRP3 activation and inflammasome assembly. This process can be induced by the activation of Toll-like receptors (by LPS), through a non-transcriptional pathway dependent on the mitochondrial production of reactive oxygen species, and by ATP.	Belongs to the NLRP family.	NOD-like receptor signaling pathway;Pertussis;Influenza A;The NLRP3 inflammasome;Metalloprotease DUBs	PE1	1
+NX_Q96P26	Cytosolic 5'-nucleotidase 1B	610	68804	9.03	0	Cytoplasm	NA	Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).	NA	Belongs to the 5'-nucleotidase type 3 family.	Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Purine catabolism	PE1	2
+NX_Q96P31	Fc receptor-like protein 3	734	80856	6.56	1	Cell membrane	Rheumatoid arthritis	Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).	Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.	NA	NA	PE1	1
+NX_Q96P44	Collagen alpha-1(XXI) chain	957	99369	8.57	0	Cytoplasm;Cytosol;Extracellular matrix	NA	NA	NA	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.	Collagen biosynthesis and modifying enzymes;Collagen chain trimerization	PE1	6
+NX_Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	875	95044	8.22	0	Cytoplasm	NA	GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.	NA	Belongs to the centaurin gamma-like family.	NA	PE1	7
+NX_Q96P48	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1	1450	162192	5.86	0	Cytoplasm;Cell membrane;Golgi stack membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).	NA	NA	Endocytosis;Rho GTPase cycle;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	PE1	11
+NX_Q96P50	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3	834	92495	5.69	0	Golgi apparatus;Nucleoplasm	NA	GTPase-activating protein for the ADP ribosylation factor family.	NA	NA	Endocytosis	PE1	1
+NX_Q96P53	WD repeat and FYVE domain-containing protein 2	400	45154	6.46	0	Cytoplasm;Early endosome;Endosome	NA	Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).	NA	NA	NA	PE1	13
+NX_Q96P56	Cation channel sperm-associated protein 2	530	62041	6.83	6	Flagellum membrane	Deafness-infertility syndrome	Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.	NA	Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.	Sperm Motility And Taxes	PE1	15
+NX_Q96P63	Serpin B12	405	46276	5.36	0	Cytoplasm	NA	Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.	NA	Belongs to the serpin family. Ov-serpin subfamily.	Neutrophil degranulation	PE1	18
+NX_Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	663	73070	7.03	0	NA	NA	Putative GTPase-activating protein.	NA	Belongs to the centaurin gamma-like family.	NA	PE2	10
+NX_Q96P65	Pyroglutamylated RF-amide peptide receptor	431	49488	9.27	7	Cell membrane	NA	Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (q) signalling events;Orexin and neuropeptides FF and QRFP bind to their respective receptors	PE2	4
+NX_Q96P66	Probable G-protein coupled receptor 101	508	56716	5.51	7	Cell membrane	Pituitary adenoma 2, growth hormone-secreting	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	X
+NX_Q96P67	Probable G-protein coupled receptor 82	336	38409	9.21	6	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	X
+NX_Q96P68	2-oxoglutarate receptor 1	337	38251	8.54	7	Cell membrane	NA	Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Class A/1 (Rhodopsin-like receptors)	PE2	13
+NX_Q96P69	G-protein coupled receptor 78	363	39332	10.26	7	Cell membrane	NA	Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	4
+NX_Q96P70	Importin-9	1041	115963	4.71	0	Cytoplasm;Cytosol;Nucleus;Cytoplasmic vesicle	NA	Functions in nuclear protein import as nuclear transport receptor (PubMed:11823430). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone (PubMed:11823430). Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains (PubMed:11823430). Mediates the nuclear import of actin (By similarity).	NA	Belongs to the importin beta family.	NA	PE1	1
+NX_Q96P71	N-terminal EF-hand calcium-binding protein 3	396	44350	5.83	0	Golgi apparatus	NA	Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3.	Phosphorylated by NEK2.;NECAB3 is phosphorylated by NEK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	20
+NX_Q96P88	Putative gonadotropin-releasing hormone II receptor	292	32537	9.45	5	Cell membrane	NA	Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.	Phosphorylated on the C-terminal cytoplasmic tail.	Belongs to the G-protein coupled receptor 1 family.	G alpha (q) signalling events;Hormone ligand-binding receptors	PE5	1
+NX_Q96PB1	N-acetylneuraminate 9-O-acetyltransferase	797	91680	9.04	15	Nucleoplasm;Golgi apparatus membrane	NA	O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids (PubMed:20947662, PubMed:26169044). Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and are involved in various processes such as cell-cell interactions, host-pathogen recognition (PubMed:20947662, PubMed:26169044).	N-glycosylated.	Belongs to the PC-esterase family. CASD1 subfamily.	NA	PE1	7
+NX_Q96PB7	Noelin-3	478	54930	8.29	0	Cytoplasmic vesicle;Secreted;Synapse	NA	NA	NA	NA	NA	PE1	1
+NX_Q96PB8	Leucine-rich repeat-containing protein 3B	259	29275	6.49	1	Membrane	NA	NA	NA	Belongs to the LRRC3 family.	NA	PE1	3
+NX_Q96PC2	Inositol hexakisphosphate kinase 3	410	46417	8.28	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.	NA	Belongs to the inositol phosphokinase (IPK) family.	Synthesis of pyrophosphates in the cytosol	PE1	6
+NX_Q96PC3	AP-1 complex subunit sigma-3	154	18280	6.32	0	Cytoplasmic vesicle membrane;Golgi apparatus;Clathrin-coated pit;Cytoplasmic vesicle	Psoriasis 15, pustular	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904).	NA	Belongs to the adaptor complexes small subunit family.	Lysosome;MHC class II antigen presentation;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Nef mediated downregulation of MHC class I complex cell surface expression	PE1	2
+NX_Q96PC5	Melanoma inhibitory activity protein 2	1412	159836	4.61	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:27138255, PubMed:21525241, PubMed:25202031, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179).	NA	Belongs to the MIA/OTOR family.	Cargo concentration in the ER	PE1	14
+NX_Q96PD2	Discoidin, CUB and LCCL domain-containing protein 2	775	85035	6.77	1	Membrane;Golgi apparatus;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	3
+NX_Q96PD4	Interleukin-17F	163	18045	9.15	0	Secreted	Candidiasis, familial, 6	Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).	NA	Belongs to the IL-17 family.	Interleukin-17 signaling;Interleukin-4 and Interleukin-13 signaling	PE1	6
+NX_Q96PD5	N-acetylmuramoyl-L-alanine amidase	576	62217	7.25	0	Membrane;Cell junction;Secreted	NA	May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.	NA	Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.	Antimicrobial peptides	PE1	19
+NX_Q96PD6	2-acylglycerol O-acyltransferase 1	335	38812	9.52	3	Endoplasmic reticulum membrane	NA	Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).	NA	Belongs to the diacylglycerol acyltransferase family.	Glycerolipid metabolism; triacylglycerol biosynthesis.;Triglyceride biosynthesis	PE2	2
+NX_Q96PD7	Diacylglycerol O-acyltransferase 2	388	43831	9.46	2	Perinuclear region;Endoplasmic reticulum membrane;Lipid droplet	NA	Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).	NA	Belongs to the diacylglycerol acyltransferase family.	Glycerolipid metabolism; triacylglycerol biosynthesis.;Glycerolipid metabolism;Metabolic pathways;Fat digestion and absorption;Triglyceride biosynthesis;Acyl chain remodeling of DAG and TAG	PE1	11
+NX_Q96PE1	Adhesion G protein-coupled receptor A2	1338	142647	8.82	7	Filopodium;Cell membrane	NA	Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).	Glycosylated.;Proteolytically cleaved into two subunits, an extracellular subunit and a seven-transmembrane subunit (PubMed:22013897, PubMed:16982628). Cleaved by thrombin (F2) and MMP1 (PubMed:22013897). Also cleaved by MMP9, with lower efficiency (PubMed:22013897, PubMed:16982628). Presence of the protein disulfide-isomerase P4HB at the cell surface is additionally required for shedding of the extracellular subunit, suggesting that the subunits are linked by disulfide bonds (PubMed:22013897). Shedding is enhanced by the growth factor FGF2 and may promote cell survival during angiogenesis (PubMed:16982628).	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	8
+NX_Q96PE2	Rho guanine nucleotide exchange factor 17	2063	221673	5.9	0	Cytosol	NA	Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	11
+NX_Q96PE3	Inositol polyphosphate-4-phosphatase type I A	977	109956	6.53	0	Cytoplasm;Cell membrane;Nucleus membrane;Nucleoplasm;Recycling endosome membrane;Postsynaptic density;Early endosome membrane;Nucleus	NA	Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.;Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:20463662, PubMed:15716355). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:30071275) (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity).	NA	Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.	Signal transduction; phosphatidylinositol signaling pathway.;Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of IP2, IP, and Ins in the cytosol	PE1	2
+NX_Q96PE5	Opalin	141	15683	5.83	1	Golgi apparatus;Cell membrane	NA	NA	NA	NA	NA	PE1	10
+NX_Q96PE6	Zinc finger imprinted 3	472	54498	9.43	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q96PE7	Methylmalonyl-CoA epimerase, mitochondrial	176	18749	9.17	0	Cytoplasm;Mitochondrion;Nucleolus	Methylmalonyl-CoA epimerase deficiency	NA	NA	Belongs to the methylmalonyl-CoA epimerase family.	Valine, leucine and isoleucine degradation;Glyoxylate and dicarboxylate metabolism;Propanoate metabolism;Metabolic pathways;Propionyl-CoA catabolism	PE1	2
+NX_Q96PF1	Protein-glutamine gamma-glutamyltransferase Z	710	79941	6.54	0	NA	NA	Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.	NA	Belongs to the transglutaminase superfamily. Transglutaminase family.	NA	PE1	15
+NX_Q96PF2	Testis-specific serine/threonine-protein kinase 2	358	40939	9.02	0	Cytoplasm;Centriole	NA	Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.	Autophosphorylated.;Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.;Autophosphorylated	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	22
+NX_Q96PG1	Putative membrane-spanning 4-domains subfamily A member 4E	132	15209	8.42	2	Membrane	NA	NA	NA	Belongs to the MS4A family.	NA	PE2	11
+NX_Q96PG2	Membrane-spanning 4-domains subfamily A member 10	267	29747	9.14	4	Membrane	NA	May be involved in signal transduction as a component of a multimeric receptor complex.	NA	Belongs to the MS4A family.	NA	PE1	11
+NX_Q96PG8	Bcl-2-binding component 3, isoforms 3/4	261	26498	11.98	0	NA	NA	Does not affect cell growth.	NA	NA	NA	PE1	19
+NX_Q96PH1	NADPH oxidase 5	765	86439	8.88	7	Membrane;Endoplasmic reticulum	NA	Are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.;Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis.	NA	NA	Detoxification of Reactive Oxygen Species	PE1	15
+NX_Q96PH6	Beta-defensin 118	123	13614	6.88	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	20
+NX_Q96PI1	Small proline-rich protein 4	79	8793	9.76	0	Cytoplasm;Cell cortex	NA	Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification.	Cross-linked to membrane proteins by transglutaminase.	Belongs to the cornifin (SPRR) family.	NA	PE2	1
+NX_Q96PJ5	Fc receptor-like protein 4	515	57224	6.08	1	Cell membrane	NA	May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.	Phosphorylated on cytoplasmic tyrosines upon activation.	NA	NA	PE1	1
+NX_Q96PK6	RNA-binding protein 14	669	69492	9.68	0	Cytoplasm;Nucleus;Nucleus speckle;Nucleolus	NA	Functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).;May function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1.	NA	NA	RUNX2 regulates bone development	PE1	11
+NX_Q96PL1	Secretoglobin family 3A member 2	93	10161	6.71	0	Secreted	NA	Secreted cytokine-like protein (PubMed:12847263). Binds to the scavenger receptor MARCO (PubMed:12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung (PubMed:24213919). May play a role in fetal lung development and maturation (PubMed:24213919). Promotes branching morphogenesis during early stages of lung development (PubMed:24213919). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity).	NA	Belongs to the secretoglobin family. UGRP subfamily.	Scavenging by Class A Receptors	PE1	5
+NX_Q96PL2	Beta-tectorin	329	36956	8.34	0	Extracellular matrix;Cell membrane	NA	One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.	The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE2	10
+NX_Q96PL5	Erythroid membrane-associated protein	475	52605	8.75	1	Golgi apparatus;Cytoplasm;Cytosol;Cell membrane	NA	Possible role as a cell-adhesion or receptor molecule of erythroid cells.	Glycosylated.	Belongs to the immunoglobulin superfamily. BTN/MOG family.	NA	PE1	1
+NX_Q96PM5	RING finger and CHY zinc finger domain-containing protein 1	261	30110	6.26	0	Cytoplasm;Nucleus speckle;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.	Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability.	NA	Protein modification; protein ubiquitination.;p53 signaling pathway;Ubiquitin mediated proteolysis;Measles;Antigen processing: Ubiquitination &amp; Proteasome degradation;Translesion Synthesis by POLH	PE1	4
+NX_Q96PM9	Zinc finger protein 385A	386	40454	9.88	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Dendrite	NA	RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.	Ubiquitinated upon prolonged exposure to genotoxic stress, which leads to proteasomal degradation of ZNF385A and releases p53/TP53 from cell-cycle arrest target gene promoters.	NA	Transcriptional activation of cell cycle inhibitor p21;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Regulation of TP53 Activity through Association with Co-factors	PE1	12
+NX_Q96PN6	Adenylate cyclase type 10	1610	187149	6.99	0	Cytoplasm;Mitochondrion;Cell membrane;Cilium;Perinuclear region;Nucleus;Cytoskeleton	Hypercalciuria absorptive 2	Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).	Cleavage may occur to generate the active 48 kDa form.	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Purine metabolism;Hedgehog 'off' state	PE1	1
+NX_Q96PN7	Transcriptional-regulating factor 1	1200	132256	6.26	0	Nucleoplasm;Nucleus;Cytosol;Nucleolus	NA	Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.	NA	NA	NA	PE1	6
+NX_Q96PN8	Testis-specific serine/threonine-protein kinase 3	268	30102	6.25	0	Nucleoplasm;Nucleus;Nucleolus	NA	May be involved in a signaling pathway during male germ cell development or mature sperm function.	Autophosphorylated.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	1
+NX_Q96PP4	Testis-specific gene 13 protein	275	31778	10.07	0	NA	NA	NA	NA	NA	NA	PE1	7
+NX_Q96PP8	Guanylate-binding protein 5	586	66617	5.38	0	Cytoplasm;Golgi apparatus membrane	NA	As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).	Isoprenylation is required for proper subcellular location.	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	Interferon gamma signaling	PE1	1
+NX_Q96PP9	Guanylate-binding protein 4	640	73165	5.73	0	Golgi apparatus;Cytoplasm;Cell membrane;Golgi apparatus membrane;Perinuclear region;Nucleus	NA	Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	Interferon gamma signaling	PE1	1
+NX_Q96PQ0	VPS10 domain-containing receptor SorCS2	1159	128152	6.64	1	Dendritic spine;Synaptosome;Cell membrane;Perikaryon;Cell projection;Nucleoplasm;Cytoplasmic vesicle membrane;Recycling endosome membrane;Postsynaptic density;Early endosome membrane;Cytosol;Dendrite	NA	SorCS2 104 kDa chain and SorCS2 18 kDa chain together promote Schwann cell apoptosis in response to proBDNF.;The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:22155786, PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814). Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (PubMed:22155786). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (By similarity).;SorCS2 122 kDa chain: Does not promote Schwann cell apoptosis in response to proBDNF.	Proteolytic cleavage removes a propeptide, giving rise to a 122 kDa chain that includes a cytoplasmic tail. Further cleavage gives rise to a 104 kDa chain that lacks the cytoplasmic tail, and a membrane-bound 18 kDa chain. The 104 kDa chain remains bound to the 18 kDa chain.;N-glycosylated.	Belongs to the VPS10-related sortilin family. SORCS subfamily.	NA	PE1	4
+NX_Q96PQ1	Sialic acid-binding Ig-like lectin 12	595	64984	6.21	1	Membrane	NA	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.	NA	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q96PQ5	Putative protein phosphatase inhibitor 2-like protein 1	205	22863	4.73	0	NA	NA	Inhibitor of protein-phosphatase 1.	NA	Belongs to the protein phosphatase inhibitor 2 family.	NA	PE5	6
+NX_Q96PQ6	Zinc finger protein 317	595	67959	9.21	0	Nucleoplasm;Nucleus	NA	May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96PQ7	Kelch-like protein 5	755	84457	6.2	0	Cytoskeleton	NA	NA	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	4
+NX_Q96PR1	Potassium voltage-gated channel subfamily C member 2	638	70226	8.24	6	Presynaptic cell membrane;Cell membrane;Postsynaptic cell membrane;Basolateral cell membrane;Synaptosome;Perikaryon;Membrane;Synapse;Cytosol;Apical cell membrane;Axon;Dendrite	NA	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity).	Phosphorylated by PKA in cortical synaptosomes. CAMP-dependent phosphorylation inhibits channel activity (By similarity). Histamine H2 receptor- and PKA-induced phosphorylation extends action potential spike duration, reduces action potential spike amplitude, sustains maximum firing frequency in hippocampal interneurons; also reduces the incidence of high-frequency oscillations in hippocampal CA3 pyramidal cell layers.	Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily.	Voltage gated Potassium channels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	PE1	12
+NX_Q96PS1	FANCD2 opposite strand protein	177	20188	9.45	0	NA	NA	NA	NA	NA	NA	PE2	3
+NX_Q96PS6	Putative uncharacterized protein GAFA-1	74	8425	8.48	1	Membrane	NA	NA	NA	NA	NA	PE4	14
+NX_Q96PS8	Aquaporin-10	301	31763	6.29	6	Lipid droplet;Cell membrane;Cytoplasmic vesicle;Apical cell membrane;Nucleus	NA	Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH (PubMed:12084581, PubMed:21733844, PubMed:23382902, PubMed:30420639). The channel is permeable to glycerol, especially when the cytosolic pH is acidified (PubMed:21733844, PubMed:30420639). Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation (PubMed:23382902). May contribute to water transport in the intestine (Probable).;Water channel that mediates water transport across cell membranes, but that is not permeable to glycerol.	NA	Belongs to the MIP/aquaporin (TC 1.A.8) family.	Passive transport by Aquaporins	PE1	1
+NX_Q96PT3	Double homeobox protein 5	197	22164	10.66	0	Nucleus	NA	NA	NA	Belongs to the paired homeobox family.	NA	PE2	unknown
+NX_Q96PT4	Putative double homeobox protein 3	197	22130	10.87	0	Nucleus	NA	NA	NA	Belongs to the paired homeobox family.	NA	PE2	unknown
+NX_Q96PU4	E3 ubiquitin-protein ligase UHRF2	802	89985	8.55	0	Nucleoplasm;Nucleus	NA	E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.	Autosumoylated.;May be autoubiquitinated; which may lead to proteasomal degradation.;Phosphorylated. Phosphorylation may be mediated by CDK2.	NA	Protein modification; protein ubiquitination.;SUMOylation of transcription cofactors	PE1	9
+NX_Q96PU5	E3 ubiquitin-protein ligase NEDD4-like	975	111932	5.56	0	Golgi apparatus;Cytoplasm;Multivesicular body	Periventricular nodular heterotopia 7	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338).	Auto-ubiquitinated (PubMed:19343052). Deubiquitinated by USP36, no effect on NEDD4L protein levels. Both proteins interact and regulate each other's ubiquitination levels (PubMed:27445338).;Phosphorylated by SGK1 or PKA; which impairs interaction with SCNN. Interaction with YWHAH inhibits dephosphorylation.;NEDD4L is phosphorylated by SGK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);NEDD4L is phosphorylated by WNK1	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Stimuli-sensing channels;Budding and maturation of HIV virion;Downregulation of TGF-beta receptor signaling	PE1	18
+NX_Q96PU8	Protein quaking	341	37671	8.63	0	Cytoplasm;Nucleoplasm;Nucleus	NA	RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).	Methylated by PRMT1.;Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).	NA	Signaling by BRAF and RAF fusions	PE1	6
+NX_Q96PU9	Outer dense fiber protein 3	254	27710	9.9	0	Cytoplasm	NA	Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail.	NA	Belongs to the ODF3 family.	NA	PE1	11
+NX_Q96PV0	Ras/Rap GTPase-activating protein SynGAP	1343	148284	9.12	0	Nucleoplasm	Mental retardation, autosomal dominant 5	Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).	Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity (By similarity).;SYNGAP1 is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);SYNGAP1 is phosphorylated by PLK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Regulation of RAS by GAPs;Signaling by RAS mutants	PE1	6
+NX_Q96PV4	Paraneoplastic antigen-like protein 5	448	49934	6.33	0	NA	NA	NA	NA	Belongs to the PNMA family.	NA	PE1	X
+NX_Q96PV6	Leukocyte receptor cluster member 8	800	88157	9.24	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q96PV7	Protein FAM193B	902	96543	8.18	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	NA	NA	NA	Belongs to the FAM193 family.	NA	PE1	5
+NX_Q96PX1	E3 ubiquitin ligase RNF157	679	73579	4.6	0	Golgi apparatus;Cytoplasm;Cytoplasmic vesicle	NA	E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764).	Phosphorylation at Ser-660, Ser-661, Ser-662 and Ser-663 downstream of the PI3K and MAPK pathways influences the E3 ligase activity and stability of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent manner (PubMed:28655764).	NA	NA	PE1	17
+NX_Q96PX6	Coiled-coil domain-containing protein 85A	553	59976	9.03	0	Adherens junction	NA	May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family.	NA	Belongs to the CCDC85 family.	NA	PE1	2
+NX_Q96PX8	SLIT and NTRK-like protein 1	696	77735	6.01	1	Membrane;Secreted;Synapse	Trichotillomania	It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Enhances neuronal dendrite outgrowth (PubMed:16224024, PubMed:19640509).	Undergoes proteolytic cleavage that results in shedding of the ectodomain and cleavage of the C-terminal cytoplasmic tail. Glycosylated. Phosphorylation at Ser-695 is necessary for proper function in promoting neurite outgrowth.	Belongs to the SLITRK family.	Receptor-type tyrosine-protein phosphatases	PE1	13
+NX_Q96PX9	Pleckstrin homology domain-containing family G member 4B	1271	139667	6.33	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	5
+NX_Q96PY0	Putative uncharacterized protein PSMG3-AS1	264	28245	11.15	0	NA	NA	NA	NA	NA	NA	PE5	7
+NX_Q96PY5	Formin-like protein 2	1086	123321	6.98	0	Golgi apparatus;Cytosol;Cytoplasm;Cell membrane	NA	Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.	NA	Belongs to the formin homology family.	RHO GTPases Activate Formins	PE1	2
+NX_Q96PY6	Serine/threonine-protein kinase Nek1	1258	142828	5.67	0	Cytoplasm;Centriolar satellite;Nucleoplasm;Centrosome;Cytosol;Nucleus	Amyotrophic lateral sclerosis 24;Short-rib thoracic dysplasia 6 with or without polydactyly	Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617).	NA	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	NA	PE1	4
+NX_Q96PZ0	Pseudouridylate synthase 7 homolog	661	75035	5.98	0	Nucleoplasm;Nucleus	Intellectual developmental disorder with abnormal behavior, microcephaly, and short stature	Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141).	NA	Belongs to the pseudouridine synthase TruD family.	tRNA modification in the nucleus and cytosol	PE1	7
+NX_Q96PZ2	Protein FAM111A	611	70196	8.77	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	Kenny-Caffey syndrome 2;Gracile bone dysplasia	Chromatin-associated protein required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis (PubMed:24561620). May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction (PubMed:23093934).	NA	Belongs to the FAM111 family.	NA	PE1	11
+NX_Q96PZ7	CUB and sushi domain-containing protein 1	3564	388736	5.64	1	Membrane;Cytoplasmic vesicle	NA	Potential suppressor of squamous cell carcinomas.	NA	Belongs to the CSMD family.	NA	PE1	8
+NX_Q96Q04	Serine/threonine-protein kinase LMTK3	1460	153661	4.77	1	Cell junction;Membrane;Nucleoplasm;Golgi apparatus membrane;Axon;Dendrite	NA	Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).		Belongs to the protein kinase superfamily. Tyr protein kinase family.	NA	PE1	19
+NX_Q96Q05	Trafficking protein particle complex subunit 9	1148	128530	6.17	0	Golgi apparatus;Cytoplasm;Endoplasmic reticulum;Nucleoplasm;cis-Golgi network;Cytoplasmic vesicle	Mental retardation, autosomal recessive 13	Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.	NA	Belongs to the NIBP family.	COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs	PE1	8
+NX_Q96Q06	Perilipin-4	1357	134431	8.92	0	Cytoplasm;Cell membrane;Lipid droplet;Cytoplasmic vesicle;Cytosol	NA	May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).	NA	Belongs to the perilipin family.	NA	PE1	19
+NX_Q96Q07	BTB/POZ domain-containing protein 9	612	69188	5.48	0	Nucleoplasm	Restless legs syndrome 6	NA	NA	NA	NA	PE1	6
+NX_Q96Q11	CCA tRNA nucleotidyltransferase 1, mitochondrial	434	50128	8.14	0	Mitochondrion	Sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay;Retinitis pigmentosa and erythrocytic microcytosis	Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).;Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates.	NA	Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.	RNA transport;tRNA processing in the nucleus;tRNA processing in the mitochondrion	PE1	3
+NX_Q96Q15	Serine/threonine-protein kinase SMG1	3661	410501	6.03	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.	Autophosphorylated.	Belongs to the PI3/PI4-kinase family.	mRNA surveillance pathway;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PE1	16
+NX_Q96Q27	Ankyrin repeat and SOCS box protein 2	587	65084	7.55	0	Nucleoplasm;Cytosol;Nucleolus	NA	Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.;Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA.;Enhances adhesion of hematopoietic cells to fibronectin through targeting of filamins FLNA and FLNB for proteasomal degradation, it is transiantly expressed during hematopoietic cell differentiation.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	14
+NX_Q96Q35	Flagellum-associated coiled-coil domain-containing protein 1	445	52439	6.29	0	Cytoplasm;Cell membrane;Flagellum;Cytosol;Cytoplasmic granule	NA	NA	NA	NA	NA	PE1	2
+NX_Q96Q40	Cyclin-dependent kinase 15	435	49023	6.68	0	Golgi apparatus;Nucleoplasm	NA	Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	2
+NX_Q96Q42	Alsin	1657	183634	5.88	0	Cytosol;Cytoskeleton	Infantile-onset ascending spastic paralysis;Amyotrophic lateral sclerosis 2;Juvenile primary lateral sclerosis	May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity).	NA	NA	Amyotrophic lateral sclerosis (ALS);RAB GEFs exchange GTP for GDP on RABs	PE1	2
+NX_Q96Q45	Transmembrane protein 237	408	45526	6.09	4	Membrane;Cilium	Joubert syndrome 14	Component of the transition zone in primary cilia. Required for ciliogenesis.	NA	Belongs to the TMEM237 family.	NA	PE1	2
+NX_Q96Q77	Calcium and integrin-binding family member 3	187	21802	4.52	0	NA	NA	NA	NA	NA	NA	PE1	19
+NX_Q96Q80	Derlin-3	235	26679	8.64	4	Cytoplasmic vesicle;Endoplasmic reticulum membrane	NA	Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins (PubMed:16449189, PubMed:22607976). May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908).	NA	Belongs to the derlin family.	Protein processing in endoplasmic reticulum;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis	PE1	22
+NX_Q96Q83	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3	286	33375	8.58	0	Cytoplasm;Nucleoplasm;Mitochondrion;Nucleus	NA	Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:25944111). Has a strong preference for single-stranded DNA (PubMed:12486230, PubMed:12594517, PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PubMed:22055184). Also acts on RNA (PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410, PubMed:16858410). Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons (PubMed:26863196, PubMed:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:22055184, PubMed:16858410).	Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination. OTUD4 promotes USP7 and USP9X-dependent deubiquitination of 'Lys-48'-polyubiquitinated ALKBH3 promoting the repair of alkylated DNA lesions.	Belongs to the alkB family.	ALKBH3 mediated reversal of alkylation damage	PE1	11
+NX_Q96Q89	Kinesin-like protein KIF20B	1820	210629	5.54	0	Cytoplasm;Nucleus;Growth cone;Nucleolus;Nucleoplasm;Spindle pole;Spindle;Centrosome;Cytosol;Axon;Midbody;Cytoskeleton	NA	Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).	Phosphorylated during mitosis by CDK1 (PubMed:11470801, PubMed:12740395).	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	10
+NX_Q96Q91	Anion exchange protein 4	983	108248	6.66	12	Membrane	NA	Probable apical anion exchanger of the kidney cortex.	NA	Belongs to the anion exchanger (TC 2.A.31) family.	Bicarbonate transporters	PE2	5
+NX_Q96QA5	Gasdermin-A	445	49365	5.19	0	Cell membrane;Nucleoplasm;Cytosol;Perinuclear region;Nucleus	NA	May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).	NA	Belongs to the gasdermin family.	NA	PE1	17
+NX_Q96QA6	Protein yippee-like 2	119	13577	8.21	0	Nucleolus	NA	NA	NA	Belongs to the yippee family.	NA	PE1	17
+NX_Q96QB1	Rho GTPase-activating protein 7	1528	170591	5.98	0	Golgi apparatus;Cytoplasm;Focal adhesion;Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.	NA	NA	Rho GTPase cycle	PE1	8
+NX_Q96QC0	Serine/threonine-protein phosphatase 1 regulatory subunit 10	940	99058	9.22	0	Nucleoplasm;Nucleus	NA	Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).	Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.	NA	NA	PE1	6
+NX_Q96QD5	DEP domain-containing protein 7	511	58310	7.62	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	Belongs to the DEPDC7 family.	Rho GTPase cycle	PE1	11
+NX_Q96QD8	Sodium-coupled neutral amino acid transporter 2	506	56026	8.08	11	Cytoplasmic vesicle;Cell membrane	NA	Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.	Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.	Belongs to the amino acid/polyamine transporter 2 family.	Glutamatergic synapse;GABAergic synapse;Protein digestion and absorption;Amino acid transport across the plasma membrane;Glutamate Neurotransmitter Release Cycle	PE1	12
+NX_Q96QD9	UAP56-interacting factor	318	35818	11.78	0	Nucleoplasm;Nucleus speckle;Nucleus envelope	NA	Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.	NA	Belongs to the UIF family.	Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	3
+NX_Q96QE2	Proton myo-inositol cotransporter	648	70371	5.81	12	Nucleus membrane;Cell membrane	NA	H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374).	Glycosylated.	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Inositol transporters	PE1	12
+NX_Q96QE3	ATPase family AAA domain-containing protein 5	1844	207570	9.27	0	Centriolar satellite;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.	ATR may stimulate the RAD9A dissociation.	Belongs to the AAA ATPase family.	NA	PE1	17
+NX_Q96QE4	Leucine-rich repeat-containing protein 37B	947	105567	4.83	1	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	17
+NX_Q96QE5	Transcription elongation factor, mitochondrial	360	41676	9.39	0	Mitochondrion matrix;Mitochondrion;Mitochondrion nucleoid	NA	Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.	NA	Belongs to the TEFM family.	NA	PE1	17
+NX_Q96QF0	Rab-3A-interacting protein	476	53021	5.73	0	Cytoplasm;Lamellipodium;Nucleus;Cytoskeleton	NA	Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297).	NA	Belongs to the SEC2 family.	Anchoring of the basal body to the plasma membrane;VxPx cargo-targeting to cilium;BBSome-mediated cargo-targeting to cilium;RAB GEFs exchange GTP for GDP on RABs	PE1	12
+NX_Q96QF7	Acidic repeat-containing protein	691	76112	4.37	0	Cytoplasmic vesicle;Nucleus	NA	NA	NA	Belongs to the serine-aspartate repeat-containing protein (SDr) family.	NA	PE1	X
+NX_Q96QG7	Myotubularin-related protein 9	549	63462	5.98	0	Cytoplasm;Endoplasmic reticulum;Centrosome;Ruffle membrane;Perinuclear region;Cytoskeleton	NA	Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598). Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate (PubMed:22647598). The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). Stabilizes MTMR8 protein levels (PubMed:22647598). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598). Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598). Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the late endosome membrane;Synthesis of IP2, IP, and Ins in the cytosol	PE1	8
+NX_Q96QH2	PML-RARA-regulated adapter molecule 1	670	73969	9.67	0	Golgi apparatus	NA	May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.	May be phosphorylated on tyrosines.;PRAM1 is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	19
+NX_Q96QH8	Sperm acrosome-associated protein 5	159	17896	5.94	0	Secreted	NA	NA	NA	Belongs to the glycosyl hydrolase 22 family.	NA	PE1	X
+NX_Q96QI5	Heparan sulfate glucosamine 3-O-sulfotransferase 6	342	37186	10.8	1	Golgi apparatus membrane	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.	NA	Belongs to the sulfotransferase 1 family.	HS-GAG biosynthesis	PE1	16
+NX_Q96QK1	Vacuolar protein sorting-associated protein 35	796	91707	5.32	0	Cytoplasm;Early endosome;Membrane;Endosome;Late endosome;Lysosome	Parkinson disease 17	(Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus.;Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227, PubMed:28892079). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24980502, PubMed:24819384). Required for the endosomal localization of TBC1D5 (PubMed:20923837).	NA	Belongs to the VPS35 family.	WNT ligand biogenesis and trafficking	PE1	16
+NX_Q96QK8	Small integral membrane protein 14	99	10710	5.15	1	Endoplasmic reticulum membrane	NA	NA	NA	NA	NA	PE1	4
+NX_Q96QP1	Alpha-protein kinase 1	1244	138861	5.83	0	Cytosol;Centrosome	NA	Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161).	NA	Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.	NA	PE1	4
+NX_Q96QR1	Secretoglobin family 3A member 1	104	10100	8.57	0	Secreted	NA	Secreted cytokine-like protein. Inhibits cell growth in vitro.	NA	Belongs to the secretoglobin family. UGRP subfamily.	NA	PE1	5
+NX_Q96QR8	Transcriptional activator protein Pur-beta	312	33241	5.35	0	Nucleoplasm;Nucleus	NA	Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity).	NA	Belongs to the PUR DNA-binding protein family.	NA	PE1	7
+NX_Q96QS1	Tetraspanin-32	320	34631	8.81	4	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	11
+NX_Q96QS3	Homeobox protein ARX	562	58160	5.14	0	Nucleus	Mental retardation, X-linked, with or without seizures, ARX-related;Partington syndrome;Lissencephaly, X-linked 2;Agenesis of the corpus callosum, with abnormal genitalia;Epileptic encephalopathy, early infantile, 1	Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate.	NA	Belongs to the paired homeobox family. Bicoid subfamily.	NA	PE1	X
+NX_Q96QS6	Serine/threonine-protein kinase H2	385	43027	9.65	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	8
+NX_Q96QT4	Transient receptor potential cation channel subfamily M member 7	1865	212697	8.1	6	Membrane;Cytoplasmic vesicle;Cytosol;Cell membrane	Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1	Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).	Autophosphorylated.	In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily.;In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.	Mineral absorption;TRP channels	PE1	15
+NX_Q96QT6	PHD finger protein 12	1004	109698	7.94	0	Nucleoplasm;Nucleus	NA	Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA.	NA	NA	NA	PE1	17
+NX_Q96QU1	Protocadherin-15	1955	216069	4.94	1	Secreted;Cell membrane	Deafness, autosomal recessive, 23;Usher syndrome 1F;Usher syndrome 1D/F	Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.	NA	NA	NA	PE1	10
+NX_Q96QU4	Protein FRG2-like-1	278	30564	8.29	0	Nucleus	NA	NA	NA	Belongs to the FRG2 family.	NA	PE2	10
+NX_Q96QU6	1-aminocyclopropane-1-carboxylate synthase-like protein 1	501	57324	6.01	0	Golgi apparatus	NA	Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine.	NA	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	NA	PE1	11
+NX_Q96QU8	Exportin-6	1125	128883	5.94	0	Cytoplasm;Cell membrane;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.	NA	Belongs to the exportin family.	NA	PE1	16
+NX_Q96QV1	Hedgehog-interacting protein	700	78851	8.24	0	Nucleoplasm;Cytoplasm;Secreted;Cell membrane	NA	Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.	NA	Belongs to the HHIP family.	Hedgehog signaling pathway;Pathways in cancer;Basal cell carcinoma;Ligand-receptor interactions	PE1	4
+NX_Q96QV6	Histone H2A type 1-A	131	14234	10.86	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Deiminated on Arg-4 in granulocytes upon calcium entry.;Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.;Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.	Belongs to the histone H2A family.	Systemic lupus erythematosus;RMTs methylate histone arginines;HATs acetylate histones;HDACs deacetylate histones;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs	PE1	6
+NX_Q96QZ0	Pannexin-3	392	44683	8.48	4	Gap junction;Cell membrane	NA	Structural component of the gap junctions and the hemichannels.	NA	Belongs to the pannexin family.	NA	PE2	11
+NX_Q96QZ7	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1	1491	164581	7.3	0	Nucleoplasm;Tight junction;Cell junction;Cell membrane	NA	May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).		NA	Tight junction	PE1	3
+NX_Q96R05	Retinoid-binding protein 7	134	15536	7.67	0	Cytoplasm;Cytosol;Nucleus speckle	NA	Intracellular transport of retinol.	NA	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	NA	PE1	1
+NX_Q96R06	Sperm-associated antigen 5	1193	134422	4.93	0	Kinetochore;Cytoplasm;Centriolar satellite;Spindle pole;Centrosome;Spindle;Cytoplasmic granule;Midbody;Cytoskeleton	NA	Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457).	Phosphorylated by AURKA.	NA	NA	PE1	17
+NX_Q96R08	Olfactory receptor 5B12	314	35182	6.58	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q96R09	Olfactory receptor 5B2	309	34568	8.58	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	11
+NX_Q96R27	Olfactory receptor 2M4	311	35071	8.82	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	1
+NX_Q96R28	Olfactory receptor 2M2	347	39177	7.07	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	1
+NX_Q96R30	Olfactory receptor 2V2	315	35339	8.81	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	5
+NX_Q96R45	Olfactory receptor 2A7	310	34742	8.96	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_Q96R47	Olfactory receptor 2A14	310	34993	8.63	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_Q96R48	Olfactory receptor 2A5	311	35207	9.44	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	7
+NX_Q96R54	Olfactory receptor 14A2	314	34780	8.67	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	1
+NX_Q96R67	Olfactory receptor 4C12	309	34491	8.67	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q96R69	Olfactory receptor 4F4	305	34259	8.49	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	15
+NX_Q96R72	Olfactory receptor 4K3	315	35408	8.69	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	14
+NX_Q96R84	Putative olfactory receptor 1F2	312	34944	8.92	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE5	16
+NX_Q96RA2	Olfactory receptor 7D2	312	34747	6.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_Q96RB7	Olfactory receptor 5M11	305	34450	8.7	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q96RC9	Olfactory receptor 8B4	309	34404	6.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q96RD0	Olfactory receptor 8B2	313	35272	9.23	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE2	11
+NX_Q96RD1	Olfactory receptor 6C1	312	35660	9.09	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_Q96RD2	Olfactory receptor 52B2	323	36185	8.9	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q96RD3	Olfactory receptor 52E6	313	35524	8.11	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q96RD6	Pannexin-2	677	74447	8.19	4	Gap junction;Cell membrane	NA	Structural component of the gap junctions and the hemichannels.	NA	Belongs to the pannexin family.	Electric Transmission Across Gap Junctions	PE1	22
+NX_Q96RD7	Pannexin-1	426	48050	5.75	4	Gap junction;Endoplasmic reticulum membrane;Cell membrane	NA	Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.	S-nitrosylation inhibits channel currents and ATP release.	Belongs to the pannexin family.	The NLRP3 inflammasome;Electric Transmission Across Gap Junctions	PE1	11
+NX_Q96RD9	Fc receptor-like protein 5	977	106437	6.7	1	Cell membrane	NA	May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.	NA	NA	NA	PE1	1
+NX_Q96RE7	Nucleus accumbens-associated protein 1	527	57258	5.52	0	Nucleoplasm;Cytoplasm;Nucleus;Cytoplasmic vesicle	Neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination	Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.	NA	NA	NA	PE1	19
+NX_Q96RE9	Zinc finger protein 300	604	68743	9	0	Nucleoplasm;Nucleolus;Nucleus	NA	Has a transcriptional repressor activity.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	5
+NX_Q96RF0	Sorting nexin-18	628	68894	5.44	0	Cell membrane;Endosome membrane;Endomembrane system;Cytoplasmic vesicle membrane;Cytosol	NA	Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane.	NA	Belongs to the sorting nexin family.	Clathrin-mediated endocytosis	PE1	5
+NX_Q96RG2	PAS domain-containing serine/threonine-protein kinase	1323	142929	4.75	0	Cytoplasm;Cytosol;Nucleus	NA	Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.	Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	2
+NX_Q96RI0	Proteinase-activated receptor 4	385	41133	9.17	7	Cytosol;Cell membrane	NA	Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.	A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events;Thrombin signalling through proteinase activated receptors (PARs)	PE1	19
+NX_Q96RI1	Bile acid receptor	486	55914	6.39	0	Nucleoplasm;Nucleus	Cholestasis, progressive familial intrahepatic, 5	Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA), NR0B2/SHP (inducible by unconjugated CDCA DCA and ACA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; not inducible by taurine- and glycine-amidated CDCA.;Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response (PubMed:10334992, PubMed:10334993, PubMed:21383957, PubMed:22820415). The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity (By similarity). In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). Activates transcription of the repressor MAFG (involved in regulation of BA synthesis) (By similarity). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:12754200, PubMed:15471871, PubMed:17895379). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) (PubMed:10514450, PubMed:15239098, PubMed:16269519). In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression (PubMed:12815072, PubMed:19085950). The function also involves the coordinated induction of hepatic KLB/beta-klotho expression (By similarity). Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA (PubMed:12806625, PubMed:16946559). Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly (PubMed:12660231, PubMed:12554753, PubMed:15337761). Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance) (PubMed:11579204). Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element (PubMed:11927623, PubMed:21804189). Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase) (PubMed:12891557). Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes. Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3) (By similarity). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance (PubMed:20447400). Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier (By similarity). Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells (PubMed:21242261). Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2 (PubMed:19864602). Involved in the TLR9-mediated protective mechanism in intestinal inflammation. Plays an anti-inflammatory role in liver inflammation; proposed to inhibit proinflammatory (but not antiapoptotic) NF-kappa-B signaling) (By similarity).;Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA.;Promotes transcriptional activation of target genes NR0B2/SHP (inducible by unconjugated CDCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; low activity for ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA); not inducible by taurine- and glycine-amidated CDCA.;Promotes transcriptional activation of target genes NR0B2/SHP (inducible by unconjugated CDCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and IBAP; low activity for ABCB11/BSEP (inducible by unconjugated CDCA, DCA and ACA); not inducible by taurine- and glycine-amidated CDCA.	Methylation may increase transactivation of target genes.;Acetylated by EP300. Lys-227 as is the major acetylation site for EP300; the dynamicly regulated acetylation inhibits heterodimerization with RXRA and transactivation activity. Deacetylated by SIRT1.;Sumoylated upon ligand binding.;Phosphorylation by PKC/PRKCA increases transactivation activity by promoting association with PPARGC1A.;NR1H4 is phosphorylated by PRKCZ (Phosphothreonine:PTM-0254)	Belongs to the nuclear hormone receptor family. NR1 subfamily.	Bile secretion;PPARA activates gene expression;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol;Nuclear Receptor transcription pathway;Endogenous sterols;Recycling of bile acids and salts;Synthesis of bile acids and bile salts;SUMOylation of intracellular receptors	PE1	12
+NX_Q96RI8	Trace amine-associated receptor 6	345	38451	8.28	7	Cell membrane	NA	Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Amine ligand-binding receptors	PE2	6
+NX_Q96RI9	Trace amine-associated receptor 9	348	39016	6.22	7	Cell membrane	NA	Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Amine ligand-binding receptors	PE2	6
+NX_Q96RJ0	Trace amine-associated receptor 1	339	39092	8.99	7	Cell membrane	NA	Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Amine ligand-binding receptors	PE2	6
+NX_Q96RJ3	Tumor necrosis factor receptor superfamily member 13C	184	18864	8.47	1	Membrane	Immunodeficiency, common variable, 4	B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.	NA	NA	Cytokine-cytokine receptor interaction;Intestinal immune network for IgA production;HTLV-I infection;Primary immunodeficiency;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	PE1	22
+NX_Q96RJ6	Fer3-like protein	166	19017	5.11	0	Nucleus	NA	Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity).	NA	NA	NA	PE1	7
+NX_Q96RK0	Protein capicua homolog	1608	163820	8.74	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	Mental retardation, autosomal dominant 45	Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.	NA	NA	NA	PE1	19
+NX_Q96RK1	Cbp/p300-interacting transactivator 4	184	18569	5.38	0	Cytoplasmic vesicle;Cytoplasm;Nucleus	NA	Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.	NA	Belongs to the CITED family.	Activation of the TFAP2 (AP-2) family of transcription factors	PE1	1
+NX_Q96RK4	Bardet-Biedl syndrome 4 protein	519	58282	6.9	0	Cytoplasm;Centriolar satellite;Cilium;Centrosome;Flagellum;Cilium membrane;Cytosol	Bardet-Biedl syndrome 4	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.	NA	Belongs to the BBS4 family.	BBSome-mediated cargo-targeting to cilium	PE1	15
+NX_Q96RL1	BRCA1-A complex subunit RAP80	719	79727	5.35	0	Nucleoplasm;Nucleus	NA	Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.	Phosphorylated upon DNA damage by ATM or ATR.;Sumoylated.	Belongs to the RAP80 family.	G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Metalloprotease DUBs	PE1	5
+NX_Q96RL6	Sialic acid-binding Ig-like lectin 11	698	75795	7.28	1	Membrane;Golgi apparatus;Nucleoplasm	NA	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.	Phosphorylated on tyrosine residues.	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q96RL7	Vacuolar protein sorting-associated protein 13A	3174	360276	5.94	0	NA	Choreoacanthocytosis	May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane.	NA	Belongs to the VPS13 family.	NA	PE1	9
+NX_Q96RM1	Small proline-rich protein 2F	72	7805	8.73	0	Cytoplasm	NA	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).	NA	Belongs to the cornifin (SPRR) family.	Formation of the cornified envelope	PE1	1
+NX_Q96RN1	Testis anion transporter 1	970	109006	5.86	12	Membrane	Spermatogenic failure 3	Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.	N-glycosylated.	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	NA	PE1	6
+NX_Q96RN5	Mediator of RNA polymerase II transcription subunit 15	788	86753	9.49	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.	Ubiquitinated by TRIM11, leading to proteasomal degradation.	Belongs to the Mediator complex subunit 15 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	22
+NX_Q96RP3	Urocortin-2	112	12146	11.58	0	Secreted	NA	Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.	Glycosylated.	Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	Class B/2 (Secretin family receptors)	PE1	3
+NX_Q96RP7	Galactose-3-O-sulfotransferase 4	486	54166	10.2	1	Golgi stack membrane;Nucleoplasm;Cytosol	NA	Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.	NA	Belongs to the galactose-3-O-sulfotransferase family.	Protein modification; carbohydrate sulfation.	PE1	7
+NX_Q96RP8	Potassium voltage-gated channel subfamily A member 7	456	50559	7.03	6	Membrane	NA	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).	NA	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily.	Voltage gated Potassium channels	PE2	19
+NX_Q96RP9	Elongation factor G, mitochondrial	751	83471	6.58	0	Nucleoplasm;Mitochondrion	Combined oxidative phosphorylation deficiency 1	Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.	Protein biosynthesis; polypeptide chain elongation.;Mitochondrial translation elongation	PE1	3
+NX_Q96RQ1	Endoplasmic reticulum-Golgi intermediate compartment protein 2	377	42549	6.27	2	Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment membrane;Cytoplasm;Endoplasmic reticulum membrane;cis-Golgi network membrane;Nucleolus;Cytoplasmic vesicle;Nucleus	NA	Possible role in transport between endoplasmic reticulum and Golgi.	NA	Belongs to the ERGIC family.	NA	PE1	12
+NX_Q96RQ3	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	725	80473	7.66	0	Mitochondrion matrix;Mitochondrion	3-methylcrotonoyl-CoA carboxylase 1 deficiency	Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.	Acetylated.	NA	Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.;Valine, leucine and isoleucine degradation;Metabolic pathways;Branched-chain amino acid catabolism;Biotin transport and metabolism;Defective HLCS causes multiple carboxylase deficiency	PE1	3
+NX_Q96RQ9	L-amino-acid oxidase	567	62881	8.79	0	Nucleoplasm;Cytosol;Lysosome	NA	Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).	NA	Belongs to the flavin monoamine oxidase family. FIG1 subfamily.	Alanine, aspartate and glutamate metabolism;Cysteine and methionine metabolism;Valine, leucine and isoleucine degradation;Tyrosine metabolism;Phenylalanine metabolism;Tryptophan metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis;Metabolic pathways;Phenylalanine metabolism	PE1	19
+NX_Q96RR1	Twinkle protein, mitochondrial	684	77154	9.13	0	Mitochondrion nucleoid	Perrault syndrome 5;Mitochondrial DNA depletion syndrome 7;Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 3	Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.	NA	NA	Transcriptional activation of mitochondrial biogenesis	PE1	10
+NX_Q96RR4	Calcium/calmodulin-dependent protein kinase kinase 2	588	64746	6.25	0	Neuron projection;Cytoplasm;Cytosol;Nucleus	NA	Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes.;Phosphorylate CAMK1 and CAMK4.;May promote neurite elongation, while isoform 1 may promoter neurite branching.;Phosphorylates CAMK1D.;Lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth.	Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	Adipocytokine signaling pathway;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CaMK IV-mediated phosphorylation of CREB;Activation of AMPK downstream of NMDARs;Activation of RAC1 downstream of NMDARs	PE1	12
+NX_Q96RS0	Trimethylguanosine synthase	853	96620	4.84	0	Cajal body;Cytoplasm;Cytosol;Nucleolus	NA	Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.	NA	Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.	RNA transport;snRNP Assembly;PPARA activates gene expression;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PE1	8
+NX_Q96RS6	NudC domain-containing protein 1	583	66756	4.99	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	8
+NX_Q96RT1	Erbin	1412	158298	5.32	0	Nucleus speckle;Cell membrane;Basolateral cell membrane;Hemidesmosome;Nucleus membrane	NA	Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).	NA	Belongs to the LAP (LRR and PDZ) protein family.	NOD-like receptor signaling pathway;Signaling by ERBB2;Downregulation of ERBB2 signaling	PE1	5
+NX_Q96RT6	cTAGE family member 2	745	85282	5.85	1	Membrane	NA	NA	NA	Belongs to the cTAGE family.	NA	PE1	18
+NX_Q96RT7	Gamma-tubulin complex component 6	1819	200498	5.89	0	Centrosome	Microcephaly and chorioretinopathy, autosomal recessive, 1	Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.	NA	Belongs to the TUBGCP family.	Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes	PE1	22
+NX_Q96RT8	Gamma-tubulin complex component 5	1024	118321	5.58	0	Cytosol;Centrosome	NA	Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.	NA	Belongs to the TUBGCP family.	Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes	PE1	15
+NX_Q96RU2	Ubiquitin carboxyl-terminal hydrolase 28	1077	122491	5.1	0	Nucleoplasm;Nucleus	NA	Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306).	Phosphorylated upon DNA damage at Ser-67 and Ser-714, by ATM or ATR (PubMed:16901786). Phosphorylated by PRKD1 (PubMed:24623306).;Degraded upon nickel ion level or hypoxia exposure.	Belongs to the peptidase C19 family. USP28 subfamily.	Ub-specific processing proteases	PE1	11
+NX_Q96RU3	Formin-binding protein 1	617	71307	5.53	0	Cytoplasm;Cell cortex;Cell membrane;Clathrin-coated pit;Lysosome;Cytoplasmic vesicle;Cytoskeleton	NA	May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.	NA	Belongs to the FNBP1 family.	Clathrin-mediated endocytosis	PE1	9
+NX_Q96RU7	Tribbles homolog 3	358	39578	8.34	0	Nucleoplasm;Nucleus	NA	Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.	PPARA activates gene expression;PIP3 activates AKT signaling;VEGFR2 mediated vascular permeability;CD28 dependent PI3K/Akt signaling;Activation of AKT2;Negative regulation of the PI3K/AKT network	PE1	20
+NX_Q96RU8	Tribbles homolog 1	372	41009	6.86	0	Cytosol;Cell membrane	NA	Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.	NA	PE1	8
+NX_Q96RV3	Pecanex-like protein 1	2341	258676	6.8	10	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the pecanex family.	NA	PE1	14
+NX_Q96RW7	Hemicentin-1	5635	613390	6.07	0	Cytoplasm;Basement membrane;Cell junction;Cleavage furrow	Macular degeneration, age-related, 1	Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration.	NA	NA	NA	PE1	1
+NX_Q96RY5	Protein cramped-like	1269	134718	8.08	0	Nucleoplasm;Nucleolus;Nucleus;Cytosol	NA	NA	NA	Belongs to the cramped family.	NA	PE1	16
+NX_Q96RY7	Intraflagellar transport protein 140 homolog	1462	165193	5.69	0	Centrosome;Cilium;Cilium basal body	Retinitis pigmentosa 80;Short-rib thoracic dysplasia 9 with or without polydactyly	Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (PubMed:20889716, PubMed:22503633). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22503633). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity).	NA	NA	Intraflagellar transport;Hedgehog 'off' state	PE1	16
+NX_Q96S06	Lipase maturation factor 1	567	64873	9.42	5	Endoplasmic reticulum membrane	Combined lipase deficiency	Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL.	NA	Belongs to the lipase maturation factor family.	Assembly of active LPL and LIPC lipase complexes	PE1	16
+NX_Q96S07	Proline-rich protein 25	402	40998	11.09	0	NA	NA	NA	NA	NA	NA	PE2	16
+NX_Q96S15	GATOR complex protein WDR24	790	88207	6.05	0	Cytoplasmic vesicle;Cytosol;Lysosome membrane	NA	As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).	NA	Belongs to the WD repeat WDR24 family.	NA	PE1	16
+NX_Q96S16	JmjC domain-containing protein 8	264	29509	6.16	0	Cytoplasm;Endoplasmic reticulum lumen	NA	Functions as a positive regulator of TNF-induced NF-kappa-B signaling (PubMed:27671354). Regulates angiogenesis and cellular metabolism through interaction with PKM (PubMed:27199445).	N-glycosylated.	NA	NA	PE1	16
+NX_Q96S19	Methyltransferase-like 26	204	22578	7.71	0	Golgi apparatus	NA	NA	NA	Belongs to the UPF0585 family.	NA	PE1	16
+NX_Q96S21	Ras-related protein Rab-40C	281	31304	9.34	0	Cell membrane	NA	Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the small GTPase superfamily. Rab family.	Protein modification; protein ubiquitination.;RAB geranylgeranylation	PE1	16
+NX_Q96S37	Solute carrier family 22 member 12	553	59630	8.61	12	Cell membrane	Hypouricemia renal 1	Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Organic anion transport;Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)	PE1	11
+NX_Q96S38	Ribosomal protein S6 kinase delta-1	1066	118682	4.76	0	Cytoplasm;Early endosome;Membrane;Endosome;Lysosome;Nucleus	NA	May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338).	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.	NA	PE1	1
+NX_Q96S42	Nodal homolog	347	39561	6.5	0	Secreted	Heterotaxy, visceral, 5, autosomal	Essential for mesoderm formation and axial patterning during embryonic development.	NA	Belongs to the TGF-beta family.	TGF-beta signaling pathway;Signaling by NODAL;Regulation of signaling by NODAL	PE1	10
+NX_Q96S44	EKC/KEOPS complex subunit TP53RK	253	28160	9.56	0	Cytoplasm;Nucleus	Galloway-Mowat syndrome 4	Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).	NA	Belongs to the protein kinase superfamily. BUD32 family.	tRNA modification in the nucleus and cytosol;Regulation of TP53 Activity through Phosphorylation	PE1	20
+NX_Q96S52	GPI transamidase component PIG-S	555	61656	6.05	2	Endoplasmic reticulum membrane	Glycosylphosphatidylinositol biosynthesis defect 18	Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.	NA	Belongs to the PIGS family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Attachment of GPI anchor to uPAR	PE1	17
+NX_Q96S53	Dual specificity testis-specific protein kinase 2	571	63639	6.63	0	Nucleoplasm;Nucleus	NA	Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.	NA	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	NA	PE1	1
+NX_Q96S55	ATPase WRNIP1	665	72133	5.73	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.	Sumoylated with SUMO1 and SUMO2/3.	Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.	NA	PE1	6
+NX_Q96S59	Ran-binding protein 9	729	77847	6.31	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.	Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C).;Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be deubiquitinated by USP11.	Belongs to the RANBP9/10 family.	RAF/MAP kinase cascade;L1CAM interactions;MET activates RAS signaling	PE1	6
+NX_Q96S65	Cysteine/serine-rich nuclear protein 1	589	63508	4.61	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.	NA	Belongs to the AXUD1 family.	NA	PE1	3
+NX_Q96S66	Chloride channel CLIC-like protein 1	551	62023	5.36	3	Endoplasmic reticulum;Golgi apparatus;Membrane;Nucleus	NA	Seems to act as a chloride ion channel.	NA	Belongs to the chloride channel MCLC family.	NA	PE1	1
+NX_Q96S79	Ras-like protein family member 10B	203	23229	9.55	0	Cytoplasmic vesicle;Cell membrane	NA	May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.	NA	Belongs to the small GTPase superfamily. Ras family.	NA	PE2	17
+NX_Q96S82	Ubiquitin-like protein 7	380	40510	4.88	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	15
+NX_Q96S86	Hyaluronan and proteoglycan link protein 3	360	40894	6.07	0	Cytosol;Extracellular matrix;Cell membrane	NA	May function in hyaluronic acid binding.	NA	Belongs to the HAPLN family.	NA	PE1	15
+NX_Q96S90	LysM and putative peptidoglycan-binding domain-containing protein 1	227	25003	8.59	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_Q96S94	Cyclin-L2	520	58147	10.27	0	Nucleoplasm;Nucleus speckle	NA	Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.	NA	Belongs to the cyclin family. Cyclin L subfamily.	NA	PE1	1
+NX_Q96S95	Calcium/calmodulin-dependent protein kinase II inhibitor 2	79	8658	5.32	0	Nucleoplasm;Cytosol;Centrosome;Nucleus	NA	Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.	NA	Belongs to the CAMK2N family.	NA	PE1	3
+NX_Q96S96	Phosphatidylethanolamine-binding protein 4	227	25733	6.08	0	Lysosome	NA	Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization.	NA	Belongs to the phosphatidylethanolamine-binding protein family.	NA	PE1	8
+NX_Q96S97	Myeloid-associated differentiation marker	322	35274	8.53	8	Membrane;Nucleus speckle	NA	NA	NA	Belongs to the MAL family.	NA	PE1	19
+NX_Q96S99	Pleckstrin homology domain-containing family F member 1	279	31195	8.59	0	Perinuclear region;Nucleus;Lysosome	NA	May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.	NA	NA	NA	PE1	19
+NX_Q96SA4	Serine incorporator 2	455	50742	5.81	11	Membrane;Nucleoplasm;Cell membrane	NA	NA	NA	Belongs to the TDE1 family.	Serine biosynthesis	PE1	1
+NX_Q96SB3	Neurabin-2	817	89334	4.91	0	Cytoplasm;Dendritic spine;Cell membrane;Adherens junction;Lamellipodium;Filopodium;Postsynaptic density;Synapse;Ruffle membrane;Nucleus;Cytoskeleton	NA	Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.	Stimulation of D1 (but not D2) dopamine receptors induces Ser-94 phosphorylation. Dephosphorylation of Ser-94 is mediated mainly by PP1 and to a lesser extent by PP2A. Phosphorylation of spinophilin disrupts its association with F-actin, but does not affect its binding to PP1 (By similarity).	NA	NA	PE1	17
+NX_Q96SB4	SRSF protein kinase 1	655	74325	5.81	0	Cytoplasm;Microsome;Cell membrane;Nucleus matrix;Nucleoplasm;Cytosol;Nucleus	NA	Phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed.;Phosphorylates SFRS2, ZRSR2, LBR and PRM1.;Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression.;Can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation.;Can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.	Herpes simplex infection	PE1	6
+NX_Q96SB8	Structural maintenance of chromosomes protein 6	1091	126326	6.57	0	Cytoplasm;Nucleus speckle;Chromosome;Nucleoplasm;Telomere;PML body;Nucleus	NA	Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).	Sumoylated by NSMCE2/MMS21.;Ubiquitinated.;Phosphorylated.;(Microbial infection) SMC5-SMC6 complex is degraded by the activity of Hepatitis B X protein.	Belongs to the SMC family. SMC6 subfamily.	SUMOylation of DNA damage response and repair proteins	PE1	2
+NX_Q96SC8	Doublesex- and mab-3-related transcription factor A2	542	53356	8.05	0	Nucleoplasm;Mitochondrion;Nucleus	NA	May be involved in sexual development.	NA	Belongs to the DMRT family.	NA	PE1	1
+NX_Q96SD1	Protein artemis	692	78436	5.69	0	Golgi apparatus;Nucleoplasm;Nucleus	Omenn syndrome;Severe combined immunodeficiency Athabaskan type;Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-positive with sensitivity to ionizing radiation	Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.	Phosphorylation on undefined residues by PRKDC may stimulate endonucleolytic activity on 5' and 3' hairpins and overhangs. PRKDC must remain present, even after phosphorylation, for efficient hairpin opening. Also phosphorylated by ATM in response to ionizing radiation (IR) and by ATR in response to ultraviolet (UV) radiation.;DCLRE1C is phosphorylated by ATR	Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.	Non-homologous end-joining;Primary immunodeficiency;Nonhomologous End-Joining (NHEJ)	PE1	10
+NX_Q96SE0	Protein ABHD1	405	45207	5.8	1	Membrane	NA	NA	NA	Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.	NA	PE1	2
+NX_Q96SE7	Zinc finger protein 347	839	95770	9.34	0	Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96SF2	T-complex protein 1 subunit theta-like 2	557	59388	5.49	0	Cytoplasm	NA	Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.	NA	Belongs to the TCP-1 chaperonin family.	NA	PE1	22
+NX_Q96SF7	T-box transcription factor TBX15	602	65757	7.05	0	Nucleoplasm;Centrosome;Nucleus	Cousin syndrome	Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity).	NA	NA	NA	PE1	1
+NX_Q96SI1	BTB/POZ domain-containing protein KCTD15	283	31942	7.05	0	Golgi apparatus;Nucleoplasm	NA	During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.	NA	NA	Negative regulation of activity of TFAP2 (AP-2) family transcription factors	PE1	19
+NX_Q96SI9	Spermatid perinuclear RNA-binding protein	672	73653	8.91	0	Cytoplasm;Nucleus	NA	Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).	NA	NA	NA	PE1	9
+NX_Q96SJ8	Tetraspanin-18	248	27710	4.9	4	Membrane	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	11
+NX_Q96SK2	Transmembrane protein 209	561	62922	8.8	2	Membrane;Cytoplasmic vesicle;Nucleus speckle;Nucleus membrane	NA	NA	NA	NA	NA	PE1	7
+NX_Q96SK3	Zinc finger protein 607	696	80507	8.93	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96SL1	Solute carrier family 49 member 4	478	52088	8.85	12	Cytoplasmic vesicle;Lysosome membrane	NA	Electrogenic metabolite transporter.	Cleaved in lysosomes by cathepsin L between Leu-214 and Ala-261, generating a N-glycosylated N-terminal and a non-glycosylated C-terminal fragment.	Belongs to the major facilitator superfamily.	NA	PE1	3
+NX_Q96SL4	Glutathione peroxidase 7	187	20996	8.42	0	Secreted	Barrett esophagus	It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.	NA	Belongs to the glutathione peroxidase family.	Glutathione metabolism;Arachidonic acid metabolism;Detoxification of Reactive Oxygen Species	PE1	1
+NX_Q96SL8	Flt3-interacting zinc finger protein 1	496	51996	8.59	0	Nucleoplasm;Cytoplasm;Nucleus	NA	May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).	NA	NA	NA	PE1	19
+NX_Q96SM3	Probable carboxypeptidase X1	734	81668	6.19	0	Secreted	NA	May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).	NA	Belongs to the peptidase M14 family.	NA	PE1	20
+NX_Q96SN7	Protein orai-2	254	28570	8.7	4	Membrane;Nucleoplasm	NA	Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.	NA	Belongs to the Orai family.	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Elevation of cytosolic Ca2+ levels;Ion homeostasis	PE1	7
+NX_Q96SN8	CDK5 regulatory subunit-associated protein 2	1893	215038	5.44	0	Cytoplasm;Golgi apparatus;Cell junction;Centrosome;Cytoskeleton	Microcephaly 3, primary, autosomal recessive	Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity).	Phosphorylated in vitro by CDK5.	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	9
+NX_Q96SQ5	Zinc finger protein 587	575	65622	9.2	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96SQ7	Protein atonal homolog 8	321	34644	10.24	0	Nucleoplasm;Cytoplasm;Nucleus speckle;Nucleus	NA	Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (PubMed:24236640). Regulates endothelial cell proliferation, migration and tube-like structures formation (PubMed:24463812). Modulates endothelial cell differentiation through NOS3 (PubMed:24463812). May be implicated in specification and differentiation of neuronal cell lineages in the brain (By similarity). May participate in kidney development and may be involved in podocyte differentiation (By similarity). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (By similarity). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (By similarity). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (PubMed:24236640). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (By similarity).	NA	NA	NA	PE2	2
+NX_Q96SQ9	Cytochrome P450 2S1	504	55817	8.8	0	Microsome membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; fatty acid metabolism.;Metabolism of xenobiotics by cytochrome P450;Miscellaneous substrates;Xenobiotics;CYP2E1 reactions	PE1	19
+NX_Q96SR6	Zinc finger protein 382	550	64010	9.42	0	Nucleus speckle;Nucleus	NA	Functions as a sequence-specific transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q96ST2	Protein IWS1 homolog	819	91955	4.58	0	Nucleoplasm;Nucleus	NA	Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.	NA	Belongs to the IWS1 family.	Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation	PE1	2
+NX_Q96ST3	Paired amphipathic helix protein Sin3a	1273	145175	6.82	0	Nucleoplasm;Nucleus;Nucleolus	Witteveen-Kolk syndrome	Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).	SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.	NA	Huntington's disease;Factors involved in megakaryocyte development and platelet production;NoRC negatively regulates rRNA expression;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;SUMOylation of transcription cofactors;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;MECP2 regulates transcription of neuronal ligands;Loss of MECP2 binding ability to 5mC-DNA;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	15
+NX_Q96ST8	Centrosomal protein of 89 kDa	783	89590	6.36	0	Centriole;Cell membrane;Mitochondrion intermembrane space;Spindle pole;Centrosome;Cytosol	NA	Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity.	NA	NA	Anchoring of the basal body to the plasma membrane	PE1	19
+NX_Q96SU4	Oxysterol-binding protein-related protein 9	736	83185	5.77	0	Golgi apparatus;Cytoplasm;trans-Golgi network membrane;Cytoplasmic vesicle;Late endosome membrane	NA	NA	NA	Belongs to the OSBP family.	Synthesis of bile acids and bile salts	PE1	1
+NX_Q96SW2	Protein cereblon	442	50546	5.41	0	Membrane;Cytoplasm;Nucleus	Mental retardation, autosomal recessive 2A	Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.	Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex.	Belongs to the CRBN family.	Protein modification; protein ubiquitination.	PE1	3
+NX_Q96SY0	Integrator complex subunit 14	518	57471	4.99	0	Cytoplasm;Mitochondrion;Nucleus membrane;Nucleoplasm;Nucleus	NA	Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.	NA	Belongs to the INTS14 family.	RNA polymerase II transcribes snRNA genes	PE1	15
+NX_Q96SZ4	Zinc finger and SCAN domain-containing protein 10	725	80387	9.17	0	Nucleus	NA	Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.	Methylated at Gln-428 by N6AMT1.	NA	Transcriptional regulation of pluripotent stem cells	PE1	16
+NX_Q96SZ5	2-aminoethanethiol dioxygenase	270	29751	5.68	0	NA	NA	NA	NA	NA	Taurine and hypotaurine metabolism;Metabolic pathways;Degradation of cysteine and homocysteine	PE1	10
+NX_Q96SZ6	CDK5 regulatory subunit-associated protein 1	601	67689	8.52	0	Nucleus speckle;Mitochondrion	NA	Specifically inhibits CDK5 activation by CDK5R1.	NA	Belongs to the methylthiotransferase family. MiaB subfamily.	NA	PE1	20
+NX_Q96T17	MAP7 domain-containing protein 2	732	81965	8.95	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the MAP7 family.	NA	PE1	X
+NX_Q96T21	Selenocysteine insertion sequence-binding protein 2	854	95462	8.31	0	Nucleoplasm;Mitochondrion;Nucleus	Abnormal thyroid hormone metabolism	Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.	NA	NA	Selenocysteine synthesis	PE1	9
+NX_Q96T23	Remodeling and spacing factor 1	1441	163821	4.94	0	Nucleoplasm;Nucleus	NA	Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598).	NA	NA	Deposition of new CENPA-containing nucleosomes at the centromere	PE1	11
+NX_Q96T25	Zinc finger protein ZIC 5	663	68448	9.01	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).	NA	Belongs to the GLI C2H2-type zinc-finger protein family.	NA	PE1	13
+NX_Q96T37	RNA-binding protein 15	977	107189	10.09	0	Nucleoplasm;Nucleus speckle;Nucleus envelope;Nucleus membrane	NA	RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311).	Methylated at Arg-578 by PRMT1, leading to promote ubiquitination by CNOT4 and subsequent degradation by the proteasome.;Ubiquitinated by CNOT4 following methylation at Arg-578 by PRMT1.	Belongs to the RRM Spen family.	NA	PE1	1
+NX_Q96T49	Protein phosphatase 1 regulatory inhibitor subunit 16B	567	63551	6.06	0	Nucleus speckle;Cell projection;Nucleus;Cell membrane	NA	Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934).	Phosphorylated by PKA and, after PKA priming, by GSK3B. Phosphorylation by GSK3B reduces its association with PP1C and enhances PP1C activity. Dephosphorylation by its associated PP1C results in enhanced association with PP1C, but reduced PP1C activity (By similarity).	NA	NA	PE1	20
+NX_Q96T51	RUN and FYVE domain-containing protein 1	708	79818	5.54	0	Cytoplasm;Nucleus speckle;Early endosome membrane;Cytoplasmic vesicle;Cytosol	NA	Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.	Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting.	NA	Endocytosis;Synthesis of PIPs at the plasma membrane	PE1	5
+NX_Q96T52	Mitochondrial inner membrane protease subunit 2	175	19718	9.43	1	Mitochondrion inner membrane;Mitochondrion	Gilles de la Tourette syndrome	Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.	NA	Belongs to the peptidase S26 family. IMP2 subfamily.	Protein export	PE1	7
+NX_Q96T53	Ghrelin O-acyltransferase	435	49716	8.82	7	Golgi apparatus;Endoplasmic reticulum membrane	NA	Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.	NA	Belongs to the membrane-bound acyltransferase family.	Synthesis, secretion, and deacylation of Ghrelin	PE1	8
+NX_Q96T54	Potassium channel subfamily K member 17	332	36895	8.61	4	Membrane;Nucleoplasm;Cytosol;Cell membrane	NA	Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.	NA	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	TWIK-related alkaline pH activated K+ channel (TALK);Phase 4 - resting membrane potential	PE1	6
+NX_Q96T55	Potassium channel subfamily K member 16	309	34153	8.94	4	Membrane	NA	Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.	NA	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	TWIK-related alkaline pH activated K+ channel (TALK);Phase 4 - resting membrane potential	PE1	6
+NX_Q96T58	Msx2-interacting protein	3664	402248	7.35	0	Nucleoplasm;Nucleus	NA	May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.	SPEN is phosphorylated by MAPK3	Belongs to the RRM Spen family.	NA	PE1	1
+NX_Q96T59	CMT1A duplicated region transcript 15 protein	188	20651	8.31	0	Cell membrane	NA	NA	NA	NA	NA	PE1	17
+NX_Q96T60	Bifunctional polynucleotide phosphatase/kinase	521	57076	8.73	0	Nucleoplasm;Nucleolus;Nucleus	Microcephaly, seizures, and developmental delay;Ataxia-oculomotor apraxia 4	Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.	NA	In the N-terminal section; belongs to the DNA 3' phosphatase family.	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	PE1	19
+NX_Q96T66	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3	252	28322	9.28	0	Mitochondrion	NA	Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. The pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.	NA	Belongs to the eukaryotic NMN adenylyltransferase family.	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.;Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.;Nicotinate and nicotinamide metabolism;Metabolic pathways;Nicotinate metabolism	PE1	3
+NX_Q96T68	Histone-lysine N-methyltransferase SETDB2	719	81894	7.62	0	Nucleoplasm;Nucleus;Chromosome	NA	Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	Lysine degradation;PKMTs methylate histone lysines	PE1	13
+NX_Q96T75	Down syndrome critical region protein 8	97	10969	8.71	0	NA	NA	NA	NA	NA	NA	PE1	21
+NX_Q96T76	MMS19 nucleotide excision repair protein homolog	1030	113290	5.92	0	Nucleoplasm;Spindle;Nucleus	NA	Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678362, PubMed:22678361, PubMed:29225034, PubMed:23585563). As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242).	Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination by MAGEF1-NSMCE1 ubiquitin ligase complex leading to proteasomal degradation.	Belongs to the MET18/MMS19 family.	Cytosolic iron-sulfur cluster assembly	PE1	10
+NX_Q96T83	Sodium/hydrogen exchanger 7	725	80131	5.97	14	Cytoplasmic vesicle;trans-Golgi network membrane;Recycling endosome membrane;Cell membrane	Intellectual developmental disorder, X-linked 108	Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to the regulation of Golgi apparatus volume and pH.	N-glycosylated.	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Sodium/Proton exchangers	PE1	X
+NX_Q96T88	E3 ubiquitin-protein ligase UHRF1	793	89814	7.66	0	Nucleoplasm;Nucleus	NA	Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.	Ubiquitinated; which leads to proteasomal degradation. Autoubiquitinated; interaction with USP7 leads to deubiquitination and prevents degradation. Ubiquitination and degradation takes place during M phase, when phosphorylation at Ser-639 prevents interaction with USP7 and subsequent deubiquitination. Polyubiquitination may be stimulated by DNA damage.;Phosphorylation at Ser-298 of the linker region decreases the binding to H3K9me3. Phosphorylation at Ser-639 by CDK1 during M phase impairs interaction with USP7, preventing deubiquitination and leading to degradation by the proteasome.	NA	Protein modification; protein ubiquitination.;DNA methylation	PE1	19
+NX_Q96T91	Glycoprotein hormone alpha-2	129	14163	8.58	0	Cytoplasmic vesicle;Secreted	NA	Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258).	Glycosylated.	Belongs to the glycoprotein hormones subunit alpha family.	G alpha (s) signalling events;Hormone ligand-binding receptors	PE1	11
+NX_Q96T92	Insulinoma-associated protein 2	566	59491	9.46	0	Cytoplasm;Nucleoplasm;Nucleus	NA	May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.	NA	NA	NA	PE1	14
+NX_Q96TA0	Putative protocadherin beta-18	734	80449	4.84	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein.	NA	NA	NA	PE5	5
+NX_Q96TA1	Protein Niban 2	746	84138	5.82	0	Cell membrane;Adherens junction;Membrane;Nucleoplasm;Cytosol	NA	May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.	As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.;Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane.	Belongs to the Niban family.	NA	PE1	9
+NX_Q96TA2	ATP-dependent zinc metalloprotease YME1L1	773	86455	8.86	1	Mitochondrion inner membrane;Mitochondrion;Nucleus	Optic atrophy 11	ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461).	Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form.	In the N-terminal section; belongs to the AAA ATPase family.;In the C-terminal section; belongs to the peptidase M41 family.	Processing of SMDT1	PE1	10
+NX_Q96TC7	Regulator of microtubule dynamics protein 3	470	52118	5.02	1	Mitochondrion outer membrane;Cytoplasm;Mitochondrion;Spindle pole;Mitochondrion membrane;Spindle;Nucleus;Cytoskeleton	NA	Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.	NA	Belongs to the RMDN family.	NA	PE1	15
+NX_Q99062	Granulocyte colony-stimulating factor receptor	836	92156	5.76	1	Secreted;Cell membrane	Hereditary neutrophilia;Neutropenia, severe congenital 7, autosomal recessive	Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.	N-glycosylated.	Belongs to the type I cytokine receptor family. Type 2 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Hematopoietic cell lineage;Pathways in cancer;Other interleukin signaling;Transcriptional regulation of granulopoiesis	PE1	1
+NX_Q99075	Proheparin-binding EGF-like growth factor	208	23067	9.47	1	Cell membrane;Extracellular space	NA	Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.	O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44.;Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.	NA	ErbB signaling pathway;GnRH signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;RAF/MAP kinase cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;EGFR downregulation;Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;PI3K events in ERBB4 signaling;SHC1 events in ERBB4 signaling;Nuclear signaling by ERBB4;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;EGFR Transactivation by Gastrin;Uptake and function of diphtheria toxin;Signaling by EGFR;GAB1 signalosome;GRB2 events in EGFR signaling;SHC1 events in EGFR signaling;EGFR interacts with phospholipase C-gamma;Inhibition of Signaling by Overexpressed EGFR;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Regulates Cell Motility;ERBB2 Activates PTK6 Signaling;PTK6 promotes HIF1A stabilization;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Extra-nuclear estrogen signaling;Estrogen-dependent nuclear events downstream of ESR-membrane signaling	PE1	5
+NX_Q99081	Transcription factor 12	682	72965	6.52	0	Nucleoplasm;Nucleus speckle;Nucleus	Craniosynostosis 3	Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').	NA	NA	HTLV-I infection;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Myogenesis	PE1	15
+NX_Q99102	Mucin-4	2169	231518	5.85	1	Membrane;Secreted;Cell membrane	NA	May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.	Mucin-4 beta chain is predominantly N-glycosylated.;Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain.;Mucrnin-4 alpha chain is highly O-glycosylated.	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	3
+NX_Q99217	Amelogenin, X isoform	191	21603	6.51	0	Extracellular matrix	Amelogenesis imperfecta 1E	Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.	Phosphorylated by FAM20C in vitro.	Belongs to the amelogenin family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	X
+NX_Q99218	Amelogenin, Y isoform	206	23250	6.92	0	Extracellular matrix	NA	Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.	NA	Belongs to the amelogenin family.	NA	PE2	Y
+NX_Q99250	Sodium channel protein type 2 subunit alpha	2005	227975	5.56	24	Cell membrane	Epileptic encephalopathy, early infantile, 11;Seizures, benign familial infantile, 3	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity).	Phosphorylation at Ser-1506 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.;May be ubiquitinated by NEDD4L; which would promote its endocytosis.;Sumoylated at Lys-38. Sumoylation is induced by hypoxia, increases voltage-gated sodium current and mediates the early response to acute hypoxia in neurons. Sumoylated SCN2A is located at the cell membrane.;SCN2A is phosphorylated by FYN (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	2
+NX_Q99259	Glutamate decarboxylase 1	594	66897	7.54	0	Cytoplasmic vesicle	Cerebral palsy, spastic quadriplegic 1	Catalyzes the production of GABA.	NA	Belongs to the group II decarboxylase family.	Alanine, aspartate and glutamate metabolism;beta-Alanine metabolism;Taurine and hypotaurine metabolism;Butanoate metabolism;Metabolic pathways;GABAergic synapse;Type I diabetes mellitus;GABA synthesis;GABA synthesis, release, reuptake and degradation;MECP2 regulates transcription of genes involved in GABA signaling	PE1	2
+NX_Q99417	c-Myc-binding protein	103	11967	5.71	0	Nucleoplasm;Cytoplasm;Mitochondrion;Nucleus	NA	May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.	NA	Belongs to the AMY1 family.	NA	PE1	1
+NX_Q99418	Cytohesin-2	400	46546	5.43	0	Golgi apparatus;Cytoplasm;Cell membrane;Adherens junction;Growth cone;Cell projection;Tight junction;Cytosol	NA	Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity).	NA	NA	Intra-Golgi traffic	PE1	19
+NX_Q99424	Peroxisomal acyl-coenzyme A oxidase 2	681	76827	7.32	0	Peroxisome;Cytosol;Cytoplasmic vesicle	Congenital bile acid synthesis defect 6	Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids (PubMed:27884763). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity).	NA	Belongs to the acyl-CoA oxidase family.	Primary bile acid biosynthesis;Metabolic pathways;PPAR signaling pathway;Peroxisome;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import	PE1	3
+NX_Q99426	Tubulin-folding cofactor B	244	27326	5.06	0	Cytoplasm;Cytosol;Cytoskeleton;Cell membrane	NA	Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).	Phosphorylation by PAK1 is required for normal function.;Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome.	Belongs to the TBCB family.	Post-chaperonin tubulin folding pathway	PE1	19
+NX_Q99435	Protein kinase C-binding protein NELL2	816	91346	5.44	0	Cytoplasmic vesicle;Secreted	NA	Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).	NA	NA	Regulation of commissural axon pathfinding by SLIT and ROBO	PE1	12
+NX_Q99436	Proteasome subunit beta type-7	277	29965	7.58	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.	NA	Belongs to the peptidase T1B family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	9
+NX_Q99437	V-type proton ATPase 21 kDa proteolipid subunit	205	21406	7.61	5	Vacuole membrane;Cytosol	NA	Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	NA	Belongs to the V-ATPase proteolipid subunit family.	Oxidative phosphorylation;Metabolic pathways;Lysosome;Phagosome;Synaptic vesicle cycle;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Tuberculosis;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	1
+NX_Q99439	Calponin-2	309	33697	6.94	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	NA	Belongs to the calponin family.	Neutrophil degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	19
+NX_Q99440	Uncharacterized protein encoded by LINC01587	93	10499	8.85	0	NA	NA	NA	NA	NA	NA	PE2	4
+NX_Q99442	Translocation protein SEC62	399	45862	6.67	2	Endoplasmic reticulum;Endoplasmic reticulum membrane;Cytoskeleton	NA	Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.	NA	Belongs to the SEC62 family.	Protein export;Protein processing in endoplasmic reticulum	PE1	3
+NX_Q99445	Glycosyl-phosphatidylinositol-anchored molecule-like protein	158	17730	6.1	0	Cell membrane	NA	May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage.	NA	NA	NA	PE2	8
+NX_Q99447	Ethanolamine-phosphate cytidylyltransferase	389	43835	6.44	0	Centrosome;Cytoskeleton	NA	Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine.	NA	Belongs to the cytidylyltransferase family.	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PE	PE1	17
+NX_Q99453	Paired mesoderm homeobox protein 2B	314	31621	9.02	0	Nucleoplasm;Nucleus	Congenital central hypoventilation syndrome;Neuroblastoma 2	Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.	NA	Belongs to the paired homeobox family.	NA	PE1	4
+NX_Q99456	Keratin, type I cytoskeletal 12	494	53511	4.71	0	NA	Corneal dystrophy, Meesmann	May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity).	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q99457	Nucleosome assembly protein 1-like 3	506	57593	5.01	0	Cytoplasmic vesicle;Nucleus	NA	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	X
+NX_Q99459	Cell division cycle 5-like protein	802	92251	8.22	0	Cytoplasm;Nucleoplasm;Nucleus speckle;Nucleus	NA	DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811).	Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8.	Belongs to the CEF1 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	6
+NX_Q99460	26S proteasome non-ATPase regulatory subunit 1	953	105836	5.25	0	Nucleoplasm;Cytoskeleton	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.	NA	Belongs to the proteasome subunit S1 family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	2
+NX_Q99463	Putative neuropeptide Y receptor type 6	290	33180	9.26	6	Membrane	NA	When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE5	5
+NX_Q99466	Neurogenic locus notch homolog protein 4	2003	209622	5.43	1	Nucleus;Cell membrane	NA	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).	Phosphorylated.;Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity).	Belongs to the NOTCH family.	Dorso-ventral axis formation;Notch signaling pathway;Pre-NOTCH Processing in the Endoplasmic Reticulum;Pre-NOTCH Transcription and Translation;Pre-NOTCH Processing in Golgi;Notch-HLH transcription pathway;Defective LFNG causes SCDO3;Negative regulation of NOTCH4 signaling;NOTCH4 Activation and Transmission of Signal to the Nucleus;NOTCH4 Intracellular Domain Regulates Transcription	PE1	6
+NX_Q99467	CD180 antigen	661	74179	5.96	1	Cell membrane	NA	May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).	NA	Belongs to the Toll-like receptor family.	Toll Like Receptor 4 (TLR4) Cascade	PE1	5
+NX_Q99469	SH3 and cysteine-rich domain-containing protein	402	44554	8.74	0	Nucleoplasm;Cytosol;Sarcolemma;Cell membrane	NA	Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.	NA	NA	NA	PE1	3
+NX_Q99470	Stromal cell-derived factor 2	211	23026	6.83	0	Cytoplasmic vesicle;Secreted	NA	NA	NA	NA	NA	PE1	17
+NX_Q99471	Prefoldin subunit 5	154	17328	5.94	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.	NA	Belongs to the prefoldin subunit alpha family.	Prefoldin mediated transfer of substrate to CCT/TriC	PE1	12
+NX_Q99487	Platelet-activating factor acetylhydrolase 2, cytoplasmic	392	44036	6.43	0	Membrane;Cytoplasm;Endoplasmic reticulum membrane	NA	Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.	NA	Belongs to the serine esterase family.	Ether lipid metabolism;Metabolic pathways;Platelet homeostasis	PE1	1
+NX_Q99489	D-aspartate oxidase	341	37535	8.07	0	Peroxisome;Cytosol	NA	Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.	NA	Belongs to the DAMOX/DASOX family.	Alanine, aspartate and glutamate metabolism;Peroxisome;Glyoxylate metabolism and glycine degradation;Peroxisomal protein import	PE1	6
+NX_Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	1192	124674	9.91	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Midbody ring	NA	GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity.;Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase.;Does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.	Is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage.	Belongs to the centaurin gamma-like family.	Endocytosis;Netrin-1 signaling	PE1	12
+NX_Q99496	E3 ubiquitin-protein ligase RING2	336	37655	6.38	0	Nucleoplasm;Nucleus;Chromosome	NA	E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity).	Polyubiquitinated in the presence of UBE2D3 (in vitro).;Monoubiquitinated, by auto-ubiquitination.	NA	Protein modification; protein ubiquitination.;SUMOylation of DNA damage response and repair proteins;Oxidative Stress Induced Senescence;SUMOylation of RNA binding proteins;SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins	PE1	1
+NX_Q99497	Protein/nucleic acid deglycase DJ-1	189	19891	6.33	0	Cytoplasm;Mitochondrion;Cell membrane;Nucleoplasm;Cytosol;Membrane raft;Nucleus	Parkinson disease 7	Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:28013050, PubMed:26995087). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity (PubMed:22523093). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785, PubMed:26995087). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity).	Cys-106 is easily oxidized to sulfinic acid.;Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for cell-growth promoting activity and transforming activity.;Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress.	Belongs to the peptidase C56 family.	Parkinson's disease;SUMOylation of transcription cofactors	PE1	1
+NX_Q99500	Sphingosine 1-phosphate receptor 3	378	42250	9.78	7	Cell membrane	NA	Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Lysosphingolipid and LPA receptors;Extra-nuclear estrogen signaling	PE1	9
+NX_Q99501	GAS2-like protein 1	681	72717	10.1	0	Stress fiber;Cell junction;Cell membrane;Cytoskeleton	NA	Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950).	NA	Belongs to the GAS2 family.	NA	PE1	22
+NX_Q99502	Eyes absent homolog 1	592	64593	5.79	0	Cytoplasm;Nucleoplasm;Nucleus	Branchiootorenal syndrome 1;Otofaciocervical syndrome 1;Anterior segment anomalies with or without cataract;Branchiootic syndrome 1	Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity).	Sumoylated with SUMO1.	Belongs to the HAD-like hydrolase superfamily. EYA family.	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	PE1	8
+NX_Q99504	Eyes absent homolog 3	573	62663	5.06	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.	Ser-266 phosphorylation is required for localization at sites of DNA damage and directing interaction with H2AX.	Belongs to the HAD-like hydrolase superfamily. EYA family.	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	PE1	1
+NX_Q99518	Dimethylaniline monooxygenase [N-oxide-forming] 2	535	60907	8.56	1	Microsome membrane;Endoplasmic reticulum membrane	NA	Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole.	NA	Belongs to the FMO family.	Drug metabolism - cytochrome P450;FMO oxidises nucleophiles	PE1	1
+NX_Q99519	Sialidase-1	415	45467	5.59	0	Cell membrane;Lysosome membrane;Cell junction;Lysosome;Cytoplasmic vesicle;Lysosome lumen	Sialidosis	Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.	Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane.;N-glycosylated.	Belongs to the glycosyl hydrolase 33 family.	Other glycan degradation;Sphingolipid metabolism;Lysosome;Sialic acid metabolism;Glycosphingolipid metabolism;Defective NEU1 causes sialidosis;Neutrophil degranulation	PE1	6
+NX_Q99523	Sortilin	831	92068	5.46	1	Golgi apparatus;Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;Lysosome membrane;Nucleus membrane;Membrane;Golgi stack membrane;Cytosol	NA	Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.	The N-terminal propeptide is cleaved by furin and possibly other homologous proteases.;Phosphorylation at Ser-825 facilitates the interaction with GGA1.	Belongs to the VPS10-related sortilin family. SORT1 subfamily.	Lysosome;Neurotrophin signaling pathway;Golgi Associated Vesicle Biogenesis	PE1	1
+NX_Q99525	Histone H4-like protein type G	98	11009	11.06	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).	NA	Belongs to the histone H4 family.	Systemic lupus erythematosus	PE1	6
+NX_Q99527	G-protein coupled estrogen receptor 1	375	42248	8.63	7	trans-Golgi network;Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Recycling endosome;Early endosome;Dendritic spine membrane;Basolateral cell membrane;Cytoplasmic vesicle membrane;Postsynaptic density;Golgi apparatus membrane;Mitochondrion membrane;Dendrite;Axon;Perinuclear region;Nucleus;Cytoskeleton	NA	G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.	Glycosylated.;Ubiquitinated; ubiquitination occurs at the plasma membrane and leads to proteasome-mediated degradation.	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	7
+NX_Q99536	Synaptic vesicle membrane protein VAT-1 homolog	393	41920	5.88	0	Mitochondrion outer membrane;Cytoplasm	NA	Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.	Neutrophil degranulation	PE1	17
+NX_Q99538	Legumain	433	49411	6.07	0	Cytoplasmic vesicle;Nucleoplasm;Lysosome	NA	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.	Activated by autocatalytic processing at pH 4.;Glycosylated.	Belongs to the peptidase C13 family.	Lysosome;Antigen processing and presentation;MHC class II antigen presentation;Trafficking and processing of endosomal TLR;Vitamin D (calciferol) metabolism	PE1	14
+NX_Q99541	Perilipin-2	437	48075	6.34	0	Membrane;Lipid droplet	NA	May be involved in development and maintenance of adipose tissue.	Acylated; primarily with C14, C16 and C18 fatty acids.	Belongs to the perilipin family.	PPARA activates gene expression;Chaperone Mediated Autophagy;Lipophagy;Microautophagy	PE1	9
+NX_Q99542	Matrix metalloproteinase-19	508	57357	7.22	0	Endoplasmic reticulum;Cytoplasmic vesicle;Extracellular matrix	Cavitary optic disc anomalies	Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.	Tyrosine phosphorylated by PKDCC/VLK.;Activated by autolytic cleavage after Lys-97.	Belongs to the peptidase M10A family.	Degradation of the extracellular matrix;Collagen degradation	PE1	12
+NX_Q99543	DnaJ homolog subfamily C member 2	621	71996	8.85	0	Cytosol;Nucleus	NA	Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.	Phosphorylated in M (mitotic) phase.	NA	Regulation of HSF1-mediated heat shock response	PE1	7
+NX_Q99547	M-phase phosphoprotein 6	160	19024	5.15	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.	Phosphorylated in M (mitotic) phase.	Belongs to the MPP6 family.	RNA degradation;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	16
+NX_Q99549	M-phase phosphoprotein 8	860	97182	5.81	0	Cell membrane;Chromosome;Nucleoplasm;Cytosol;Nucleus	NA	Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602).	Phosphorylated in M (mitotic) phase. Phosphorylation by CDK1 promotes dissociation from chromatin.	NA	NA	PE1	13
+NX_Q99550	M-phase phosphoprotein 9	1183	133024	5.87	0	Cell membrane;Centriole;Nucleoplasm;Golgi apparatus membrane;Cytosol	NA	NA	Phosphorylated in M (mitotic) phase.	NA	NA	PE1	12
+NX_Q99551	Transcription termination factor 1, mitochondrial	399	45778	9.49	0	Mitochondrion	NA	Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.	Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation.	Belongs to the mTERF family.	Mitochondrial transcription termination;Transcriptional activation of mitochondrial biogenesis	PE1	7
+NX_Q99558	Mitogen-activated protein kinase kinase kinase 14	947	104042	7.77	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.	Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.;Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization.;MAP3K14 is phosphorylated by MAP3K7 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway;Apoptosis;Osteoclast differentiation;T cell receptor signaling pathway;Intestinal immune network for IgA production;Epithelial cell signaling in Helicobacter pylori infection;HTLV-I infection;Dectin-1 mediated noncanonical NF-kB signaling;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;CD28 dependent PI3K/Akt signaling;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	PE1	17
+NX_Q99567	Nuclear pore complex protein Nup88	741	83542	5.47	0	Nucleoplasm;Nuclear pore complex	Fetal akinesia deformation sequence 4	Component of nuclear pore complex.	NA	NA	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	17
+NX_Q99569	Plakophilin-4	1192	131868	9.07	0	Desmosome;Cell membrane;Cell junction;Spindle;Midbody	NA	Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.	PKP4 is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the beta-catenin family.	Formation of the cornified envelope;Keratinization	PE1	2
+NX_Q99570	Phosphoinositide 3-kinase regulatory subunit 4	1358	153103	6.74	0	Membrane;Autophagosome;Late endosome;Cytoplasmic vesicle;Cytoskeleton	NA	Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).	Probably autophosphorylated.;Myristoylated.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	Regulation of autophagy;Macroautophagy;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;PI3K Cascade;Synthesis of PIPs at the late endosome membrane;Toll Like Receptor 9 (TLR9) Cascade;RHO GTPases Activate NADPH Oxidases	PE1	3
+NX_Q99571	P2X purinoceptor 4	388	43369	8.29	2	Membrane	NA	Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.	NA	Belongs to the P2X receptor family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Elevation of cytosolic Ca2+ levels;Platelet homeostasis	PE1	12
+NX_Q99572	P2X purinoceptor 7	595	68585	8.57	2	Cell membrane	NA	Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206).	ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel.;Phosphorylation results in its inactivation.;Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.	Belongs to the P2X receptor family.	The NLRP3 inflammasome;Elevation of cytosolic Ca2+ levels;Platelet homeostasis	PE1	12
+NX_Q99574	Neuroserpin	410	46427	4.84	0	Secretory vesicle lumen;Cytosol;Perikaryon;Secreted	Encephalopathy, familial, with neuroserpin inclusion bodies	Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).	NA	Belongs to the serpin family.	NA	PE1	3
+NX_Q99575	Ribonucleases P/MRP protein subunit POP1	1024	114709	9.36	0	Nucleolus	Anauxetic dysplasia 2	Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:8918471, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).	NA	NA	Ribosome biogenesis in eukaryotes;RNA transport;tRNA processing in the nucleus	PE1	8
+NX_Q99576	TSC22 domain family protein 3	134	14810	4.51	0	Golgi apparatus;Cytoplasm;Nucleus speckle;Cytosol;Nucleus	NA	Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).;Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity).	NA	Belongs to the TSC-22/Dip/Bun family.	Stimuli-sensing channels	PE1	X
+NX_Q99578	GTP-binding protein Rit2	217	24668	6.14	0	Nucleus;Cell membrane	NA	Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.	NA	Belongs to the small GTPase superfamily. Ras family.	Signalling to p38 via RIT and RIN	PE1	18
+NX_Q99581	Protein FEV	238	25030	9.28	0	Nucleus speckle;Nucleus	Sudden infant death syndrome	Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.	NA	Belongs to the ETS family.	NA	PE1	2
+NX_Q99583	Max-binding protein MNT	582	62300	8.79	0	Nucleoplasm;Nucleus	NA	Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.	NA	NA	NA	PE1	17
+NX_Q99584	Protein S100-A13	98	11471	5.9	0	Cytoplasm;Cell membrane;Secreted;Nucleolus;Nucleoplasm;Cytosol	NA	Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).	NA	Belongs to the S-100 family.	NA	PE1	1
+NX_Q99590	Protein SCAF11	1463	164652	8.69	0	Nucleoplasm;Nucleus	NA	Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly.	NA	NA	NA	PE1	12
+NX_Q99592	Zinc finger and BTB domain-containing protein 18	522	58354	5.41	0	Nucleus speckle;Nucleus	Mental retardation, autosomal dominant 22	Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.	NA	PE1	1
+NX_Q99593	T-box transcription factor TBX5	518	57711	7.14	0	Cytoplasm;Nucleoplasm;Nucleus	Holt-Oram syndrome	DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:25725155, PubMed:25963046, PubMed:29174768, PubMed:26917986, PubMed:27035640, PubMed:8988164). Binds to the core DNA motif of NPPA promoter (PubMed:26926761).	Acetylation at Lys-339 by KAT2A and KAT2B promotes nuclear retention.	NA	YAP1- and WWTR1 (TAZ)-stimulated gene expression;Physiological factors	PE1	12
+NX_Q99594	Transcriptional enhancer factor TEF-5	435	48676	8.49	0	Nucleus	NA	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.	NA	NA	YAP1- and WWTR1 (TAZ)-stimulated gene expression;RUNX3 regulates YAP1-mediated transcription	PE1	6
+NX_Q99595	Mitochondrial import inner membrane translocase subunit Tim17-A	171	18024	7.72	3	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	NA	Belongs to the Tim17/Tim22/Tim23 family.	Mitochondrial protein import	PE1	1
+NX_Q99598	Translin-associated protein X	290	33112	6.1	0	Golgi apparatus;Nucleoplasm;Cytosol;Perinuclear region;Nucleus	NA	Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.	Sumoylated with SUMO1.	Belongs to the translin family.	Small interfering RNA (siRNA) biogenesis	PE1	1
+NX_Q99603	T cell receptor gamma variable 9	122	13414	5.87	0	Cell membrane	NA	V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).	NA	NA	NA	PE1	7
+NX_Q99607	ETS-related transcription factor Elf-4	663	70730	5.41	0	Nucleoplasm;Nucleus;PML body	NA	Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.	NA	Belongs to the ETS family.	NA	PE1	X
+NX_Q99608	Necdin	321	36086	8.81	0	Nucleoplasm;Cytosol;Perikaryon;Nucleus	NA	Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity).	NA	NA	Interleukin-4 and Interleukin-13 signaling	PE1	15
+NX_Q99611	Selenide, water dikinase 2	448	47305	5.63	0	Nucleoplasm	NA	Synthesizes selenophosphate from selenide and ATP.	NA	Belongs to the selenophosphate synthase 1 family. Class I subfamily.	Selenocompound metabolism;Metabolic pathways;Selenocysteine synthesis	PE1	16
+NX_Q99612	Krueppel-like factor 6	283	31865	6.46	0	Nucleolus;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	Prostate cancer;Gastric cancer	Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	10
+NX_Q99613	Eukaryotic translation initiation factor 3 subunit C	913	105344	5.48	0	Cytoplasm	NA	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).	Phosphorylated. Phosphorylation is enhanced upon serum stimulation.	Belongs to the eIF-3 subunit C family.	RNA transport;L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	16
+NX_Q99614	Tetratricopeptide repeat protein 1	292	33526	4.78	0	Cytoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	5
+NX_Q99615	DnaJ homolog subfamily C member 7	494	56441	6.56	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).	NA	NA	Regulation of HSF1-mediated heat shock response	PE1	17
+NX_Q99616	C-C motif chemokine 13	98	10986	9.94	0	Secreted	NA	Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.	One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	17
+NX_Q99618	Cell division cycle-associated protein 3	268	28998	6.02	0	Cytosol	NA	F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).	Ubiquitinated and degraded by the APC/C-Cdh1 complex.	NA	Protein modification; protein ubiquitination.	PE1	12
+NX_Q99619	SPRY domain-containing SOCS box protein 2	263	28630	8.32	0	Cytoplasm;Cytosol	NA	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).	NA	Belongs to the SPSB family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	12
+NX_Q99622	Protein C10	126	13178	5.04	0	Cytoplasm;Nucleus speckle	Temtamy syndrome	In brain, may be required for corpus callosum development.	NA	Belongs to the UPF0456 family.	NA	PE1	12
+NX_Q99623	Prohibitin-2	299	33296	9.83	0	Cytoplasm;Mitochondrion inner membrane;Mitochondrion;Nucleus	NA	Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:20959514).	PHB2 is phosphorylated by AKT2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the prohibitin family.	Processing of SMDT1	PE1	12
+NX_Q99624	Sodium-coupled neutral amino acid transporter 3	504	55773	8.03	10	Cytosol;Cytoskeleton;Cell membrane	NA	Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.	NA	Belongs to the amino acid/polyamine transporter 2 family.	Glutamatergic synapse;GABAergic synapse;Proximal tubule bicarbonate reclamation;Amino acid transport across the plasma membrane	PE1	3
+NX_Q99626	Homeobox protein CDX-2	313	33520	9.65	0	Nucleoplasm;Nucleus	NA	Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536).	Phosphorylation of Ser-60 mediates the transactivation capacity.	Belongs to the Caudal homeobox family.	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	PE1	13
+NX_Q99627	COP9 signalosome complex subunit 8	209	23226	5.25	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.	NA	Belongs to the CSN8 family.	Formation of TC-NER Pre-Incision Complex;DNA Damage Recognition in GG-NER;Cargo recognition for clathrin-mediated endocytosis;Neddylation	PE1	2
+NX_Q99633	Pre-mRNA-splicing factor 18	342	39860	8.19	0	Cytosol;Nucleus speckle	NA	Participates in the second step of pre-mRNA splicing.	NA	Belongs to the PRP18 family.	Spliceosome	PE1	10
+NX_Q99638	Cell cycle checkpoint control protein RAD9A	391	42547	5.41	0	Nucleoplasm;Nucleus	NA	Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.	Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.;RAD9A is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the rad9 family.	Activation of ATR in response to replication stress;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	11
+NX_Q99640	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	499	54521	6.48	0	Golgi apparatus;Endoplasmic reticulum membrane;Nucleolus;Nucleoplasm;Golgi apparatus membrane	NA	Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.	Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);PKMYT1 is phosphorylated by MAPK10 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.	Cell cycle;Oocyte meiosis;Progesterone-mediated oocyte maturation;Polo-like kinase mediated events;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint	PE1	16
+NX_Q99643	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	169	18610	9.74	3	Mitochondrion inner membrane	Paragangliomas 3;Paraganglioma and gastric stromal sarcoma	Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	NA	Belongs to the cytochrome b560 family.	Carbohydrate metabolism; tricarboxylic acid cycle.;Citrate cycle (TCA cycle);Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Citric acid cycle (TCA cycle)	PE1	1
+NX_Q99645	Epiphycan	322	36637	4.67	0	Extracellular matrix	NA	May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.	The O-linked polysaccharides on Thr-60 and Ser-96 are probably the mucin type linked to GalNAc. There is one glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64 (By similarity).	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.	NA	PE1	12
+NX_Q99650	Oncostatin-M-specific receptor subunit beta	979	110509	5.54	1	Membrane;Nucleolus	Amyloidosis, primary localized cutaneous, 1	Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.	NA	Belongs to the type I cytokine receptor family. Type 2 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;IL-6-type cytokine receptor ligand interactions	PE1	5
+NX_Q99653	Calcineurin B homologous protein 1	195	22456	4.98	0	Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Cell membrane;Endomembrane system;Membrane;Endoplasmic reticulum;Cytoplasmic vesicle;Nucleus;Cytoskeleton	NA	Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.	Phosphorylated; decreased phosphorylation is associated with an increase in SLC9A1/NHE1 Na(+)/H(+) exchange activity. Phosphorylation occurs in serum-dependent manner. The phosphorylation state may regulate the binding to SLC9A1/NHE1.;Both N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic traffic (By similarity). N-myristoylation is required for its association with microtubules and interaction with GAPDH, but not for the constitutive association to membranes.	Belongs to the calcineurin regulatory subunit family. CHP subfamily.	MAPK signaling pathway;Calcium signaling pathway;Oocyte meiosis;Apoptosis;Wnt signaling pathway;Axon guidance;VEGF signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Long-term potentiation;Glutamatergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Tuberculosis;Hyaluronan uptake and degradation	PE1	15
+NX_Q99661	Kinesin-like protein KIF2C	725	81313	8.03	0	Nucleoplasm;Midbody;Centromere;Centrosome;Nucleus;Kinetochore;Cytoskeleton	NA	In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).	Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.;Ubiquitinated.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.	Separation of Sister Chromatids;MHC class II antigen presentation;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-dependent Golgi-to-ER retrograde traffic	PE1	1
+NX_Q99665	Interleukin-12 receptor subunit beta-2	862	97135	7.91	1	Membrane;Cell membrane	NA	Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.	On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.	Belongs to the type I cytokine receptor family. Type 2 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-35 Signalling;Interleukin-12 signaling	PE1	1
+NX_Q99666	RANBP2-like and GRIP domain-containing protein 5/6	1765	198924	6.03	0	Cytoplasm;Nucleus envelope	NA	NA	NA	NA	NA	PE1	2
+NX_Q99674	Cell growth regulator with EF hand domain protein 1	318	33456	4.32	0	Golgi apparatus;Secreted	NA	Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.	Probably digested extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides.	NA	NA	PE1	2
+NX_Q99675	Cell growth regulator with RING finger domain protein 1	332	38242	5.05	0	Endoplasmic reticulum;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Able to inhibit growth in several cell lines.	NA	NA	NA	PE1	14
+NX_Q99676	Zinc finger protein 184	751	86174	8.41	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	6
+NX_Q99677	Lysophosphatidic acid receptor 4	370	41895	9.28	7	Cytoplasmic vesicle;Nucleus;Cell membrane	NA	Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;P2Y receptors	PE1	X
+NX_Q99678	G-protein coupled receptor 20	358	38650	9.36	7	Cytosol;Cell membrane	NA	Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (s) signalling events	PE1	8
+NX_Q99679	Probable G-protein coupled receptor 21	349	39515	7.87	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	9
+NX_Q99680	G-protein coupled receptor 22	433	49265	9.43	7	Cell membrane	NA	Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (PubMed:18539757). May be involved in ciliogenesis (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	7
+NX_Q99683	Mitogen-activated protein kinase kinase kinase 5	1374	154537	5.52	0	Endoplasmic reticulum;Cytosol;Cytoplasm	NA	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).	Ubiquitinated. Tumor necrosis factor (TNF) induces TNFR2-dependent ubiquitination leading to proteasomal degradation.;Phosphorylated at Thr-838 through autophosphorylation and by MAP3K6/ASK2 which leads to activation. Thr-838 is dephosphorylated by PPP5C. Ser-83 and Ser-1033 are inactivating phosphorylation sites, the former of which is phosphorylated by AKT1 and AKT2. Phosphorylated at Ser-966 which induces association of MAP3K5/ASK1 with the 14-3-3 family proteins and suppresses MAP3K5/ASK1 activity. Calcineurin (CN) dephosphorylates this site. Also dephosphorylated and activated by PGAM5.;MAP3K5 is phosphorylated by IGF1R (Phosphotyrosine:PTM-0255);MAP3K5 is phosphorylated by CAMK2G (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MAP3K5 is phosphorylated by DYRK1A (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway;Protein processing in endoplasmic reticulum;Neurotrophin signaling pathway;Amyotrophic lateral sclerosis (ALS);Oxidative Stress Induced Senescence	PE1	6
+NX_Q99684	Zinc finger protein Gfi-1	422	45297	9.24	0	Nucleus	Neutropenia, severe congenital 2, autosomal dominant;Dominant nonimmune chronic idiopathic neutropenia of adults	Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.	Ubiquitinated. Ubiquitination and degradation by the proteasome is inhibited by the ubiquitin ligase, ARIH2.	NA	Transcriptional regulation of granulopoiesis	PE1	1
+NX_Q99685	Monoglyceride lipase	303	33261	6.49	0	Membrane;Nucleoplasm;Cytosol	NA	Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).	NA	Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.	Glycerolipid metabolism; triacylglycerol degradation.;Glycerolipid metabolism;Metabolic pathways;Acyl chain remodeling of DAG and TAG;Triglyceride catabolism;Arachidonate production from DAG	PE1	3
+NX_Q99687	Homeobox protein Meis3	375	41115	5	0	Nucleus	NA	Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1.	NA	Belongs to the TALE/MEIS homeobox family.	NA	PE2	19
+NX_Q99689	Fasciculation and elongation protein zeta-1	392	45119	4.24	0	Cytosol;Centrosome;Cytoskeleton;Cell membrane	NA	May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.	Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26.;Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.	Belongs to the zygin family.	NA	PE1	11
+NX_Q99697	Pituitary homeobox 2	317	35370	9.53	0	Nucleoplasm;Nucleus	Axenfeld-Rieger syndrome 1;Anterior segment dysgenesis 4;Ring dermoid of cornea	Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach.;Is involved in left-right asymmetry the developing embryo (By similarity).	Phosphorylation at Thr-90 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1.	Belongs to the paired homeobox family. Bicoid subfamily.	TGF-beta signaling pathway;TFAP2 (AP-2) family regulates transcription of other transcription factors	PE1	4
+NX_Q99698	Lysosomal-trafficking regulator	3801	429139	6.15	0	Nucleoplasm;Cytoplasm;Centriolar satellite;Cell membrane	Chediak-Higashi syndrome	May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.	NA	NA	NA	PE1	1
+NX_Q99700	Ataxin-2	1313	140283	9.6	0	Cytoplasm;Cytosol	Spinocerebellar ataxia 2;Amyotrophic lateral sclerosis 13	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.	NA	Belongs to the ataxin-2 family.	NA	PE1	12
+NX_Q99704	Docking protein 1	481	52392	6.05	0	Cytoplasm;Cytosol;Perinuclear region;Nucleus	NA	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.	Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.;DOK1 is phosphorylated by TEC (Phosphotyrosine:PTM-0255);DOK1 is phosphorylated by FYN (Phosphotyrosine:PTM-0255);DOK1 is phosphorylated by ABL2 (Phosphotyrosine:PTM-0255);DOK1 is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	Belongs to the DOK family. Type A subfamily.	Measles;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;RET signaling	PE1	2
+NX_Q99705	Melanin-concentrating hormone receptor 1	422	45963	9.23	7	Cell membrane	NA	Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (q) signalling events;BBSome-mediated cargo-targeting to cilium	PE1	22
+NX_Q99706	Killer cell immunoglobulin-like receptor 2DL4	377	41487	7.29	1	Early endosome membrane;Cell membrane	NA	Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent proinflammatory response (PubMed:20179272).	NA	Belongs to the immunoglobulin superfamily.	Antigen processing and presentation;Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q99707	Methionine synthase	1265	140527	5.39	0	Cytoplasm;Cytosol	Homocystinuria-megaloblastic anemia, cblG complementation type;Neural tube defects, folate-sensitive	Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).	NA	Belongs to the vitamin-B12 dependent methionine synthase family.	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.;Cysteine and methionine metabolism;Selenocompound metabolism;One carbon pool by folate;Metabolic pathways;Methylation;Sulfur amino acid metabolism;Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE;Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	PE1	1
+NX_Q99708	DNA endonuclease RBBP8	897	101942	5.92	0	Nucleoplasm;Nucleus;Chromosome	Seckel syndrome 2;Jawad syndrome	Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:10764811, PubMed:10910365, PubMed:15485915, PubMed:16581787, PubMed:16818604, PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:20829486). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity).	Acetylated. Deacetylation by SIRT6 upon DNA damage promotes DNA end resection.;Hyperphosphorylation upon ionizing radiation results in dissociation from BRCA1. Phosphorylation at Thr-847 by CDK1 is essential for the recruitment to DNA and the DNA repair function. Phosphorylated on Ser-327 as cells enter G2 phase. This phosphorylation is required for binding BRCA1 and for the G2/M DNA damage transition checkpoint control. Phosphorylation at Thr-315, probably catalyzed by CDK2, is required for PIN1-binding, while phosphorylation at Ser-276 serves as a PIN1 isomerization site. Phosphorylation at Thr-315 is cell-cycle dependent. It steadily increases during S phase, peaks at late S/G2 phase, and drops at G1 (PubMed:23623683).;Ubiquitinated (PubMed:14654780, PubMed:16818604, PubMed:27561354). Ubiquitination at multiple sites by BRCA1 (via its N-terminal RING domain) does not lead to its proteasomal degradation but instead the ubiquitinated RBBP8 binds to chromatin following DNA damage and may play a role in G2/M checkpoint control (PubMed:16818604). Ubiquitinated by RNF138 at its N-terminus (PubMed:26502057). Ubiquitinated through 'Lys-48' by the E3 CUL3-KLHL15 complex; this modification leads to proteasomal degradation (PubMed:27561354). Ubiquitinated by the E3 FZR1/APC/C complex; this modification leads to proteasomal degradation (PubMed:25349192).	Belongs to the COM1/SAE2/CtIP family.	Meiotic recombination;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);HDR through MMEJ (alt-NHEJ);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;Transcriptional Regulation by E2F6	PE1	18
+NX_Q99712	ATP-sensitive inward rectifier potassium channel 15	375	42577	7.6	2	Membrane;Cytoplasmic vesicle;Cytosol;Cell membrane	NA	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.	NA	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.	Gastric acid secretion;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	PE1	21
+NX_Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	261	26923	7.65	0	Mitochondrion	HDS10 mitochondrial disease	In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:24549042, PubMed:25925575, PubMed:26950678, PubMed:28888424). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit (PubMed:23042678, PubMed:25925575, PubMed:28888424). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705).;Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone (PubMed:9553139, PubMed:23042678, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Catalyzes the third step in the beta-oxidation of fatty acids (PubMed:9553139, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (PubMed:12917011). Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Valine, leucine and isoleucine degradation;Metabolic pathways;Alzheimer's disease;Branched-chain amino acid catabolism;tRNA processing in the mitochondrion;tRNA modification in the mitochondrion;rRNA processing in the mitochondrion	PE1	X
+NX_Q99715	Collagen alpha-1(XII) chain	3063	333147	5.38	0	Nucleoplasm;Extracellular matrix	Bethlem myopathy 2;Ullrich congenital muscular dystrophy 2	Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.	The triple-helical tail is stabilized by disulfide bonds at each end.;O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.;Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.	Protein digestion and absorption;Collagen degradation;Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;Collagen chain trimerization	PE1	6
+NX_Q99717	Mothers against decapentaplegic homolog 5	465	52258	7.63	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).	Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.;Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.	Belongs to the dwarfin/SMAD family.	TGF-beta signaling pathway;Signaling by BMP	PE1	5
+NX_Q99719	Septin-5	369	42777	6.21	0	Nucleoplasm;Cytosol;Cytoplasm;Cytoskeleton	NA	Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).	In platelets, phosphorylated in response to thrombin, phorbol-12-myristate-13-acetate and collagen.	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	Parkinson's disease	PE1	22
+NX_Q99720	Sigma non-opioid intracellular receptor 1	223	25128	5.61	1	Nucleus outer membrane;Endoplasmic reticulum membrane;Cell membrane;Lipid droplet;Growth cone;Cell junction;Membrane;Nucleus inner membrane;Nucleus envelope;Postsynaptic density;Cytoplasmic vesicle	Amyotrophic lateral sclerosis 16, juvenile;Distal spinal muscular atrophy, autosomal recessive, 2	Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).	NA	Belongs to the ERG2 family.	NA	PE1	9
+NX_Q99726	Zinc transporter 3	388	41945	6	6	Synaptosome;Lysosome membrane;Nucleolus;Nucleoplasm;Synaptic vesicle membrane;Cytoplasmic vesicle;Cytosol;Synaptic vesicle;Late endosome membrane	NA	Involved in accumulation of zinc in synaptic vesicles.	NA	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.	Zinc efflux and compartmentalization by the SLC30 family	PE1	2
+NX_Q99727	Metalloproteinase inhibitor 4	224	25503	7.95	0	Secreted	NA	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.	NA	Belongs to the protease inhibitor I35 (TIMP) family.	NA	PE1	3
+NX_Q99728	BRCA1-associated RING domain protein 1	777	86648	8.99	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	NA	E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.	Processed during apoptosis. The homodimer is more susceptible to proteolytic cleavage than the BARD1/BRCA1 heterodimer.	NA	Protein modification; protein ubiquitination.;G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Nonhomologous End-Joining (NHEJ);Regulation of TP53 Activity through Phosphorylation;UCH proteinases;Metalloprotease DUBs	PE1	2
+NX_Q99729	Heterogeneous nuclear ribonucleoprotein A/B	332	36225	8.21	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.	Dimethylation at Arg-322 is probably asymmetric.	NA	NA	PE1	5
+NX_Q99731	C-C motif chemokine 19	98	10993	9.84	0	Secreted	NA	May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines;Interleukin-10 signaling	PE1	9
+NX_Q99732	Lipopolysaccharide-induced tumor necrosis factor-alpha factor	161	17107	5.99	0	Cytoplasm;Nucleus;Endosome membrane;Cell membrane;Lysosome membrane;Nucleoplasm;Golgi apparatus membrane;Early endosome membrane;Cytoplasmic vesicle;Cytosol;Late endosome membrane	Charcot-Marie-Tooth disease 1C	Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429). May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005).	Phosphorylated on tyrosine residues in response to EGF.	Belongs to the CDIP1/LITAF family.	NA	PE1	16
+NX_Q99733	Nucleosome assembly protein 1-like 4	375	42823	4.6	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Acts as histone chaperone in nucleosome assembly.	Phosphorylated at the G0/G1 boundary but it is not phosphorylated in S-phase. Phosphorylated protein remains in the cytoplasm in a complex with histones during the G0/G1 transition, whereas dephosphorylation triggers its transport into the nucleus at the G1/S-boundary.;Polyglutamylated by TTLL4, a modification that occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Some residues may also be monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human (By similarity).	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	11
+NX_Q99735	Microsomal glutathione S-transferase 2	147	16621	9.6	3	Microsome membrane;Endoplasmic reticulum membrane	NA	Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.	NA	Belongs to the MAPEG family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation;Aflatoxin activation and detoxification	PE1	4
+NX_Q99741	Cell division control protein 6 homolog	560	62720	9.64	0	Cytoplasm;Nucleoplasm;Cytosol;Spindle;Nucleus;Cytoskeleton	Meier-Gorlin syndrome 5	Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.	NA	Belongs to the CDC6/cdc18 family.	Cell cycle;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Activation of ATR in response to replication stress;CDC6 association with the ORC:origin complex;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;G1/S-Specific Transcription;Transcription of E2F targets under negative control by DREAM complex	PE1	17
+NX_Q99742	Neuronal PAS domain-containing protein 1	590	62702	8.61	0	Nucleoplasm;Nucleus	NA	May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity).	NA	NA	NA	PE2	19
+NX_Q99743	Neuronal PAS domain-containing protein 2	824	91791	6.35	0	Nucleoplasm;Nucleus	NA	Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes. Controls the circadian rhythm of NR0B2 expression by binding rhythmically to its promoter (By similarity). Mediates the diurnal variation in the expression of GABARA1 receptor in the brain and contributes to the regulation of anxiety-like behaviors and GABAergic neurotransmission in the ventral striatum (By similarity).	NA	NA	Circadian rhythm - mammal;PPARA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock	PE1	2
+NX_Q99747	Gamma-soluble NSF attachment protein	312	34746	5.3	0	Membrane;Cytosol;Cell membrane	NA	Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.	NA	Belongs to the SNAP family.	COPII-mediated vesicle transport;Intra-Golgi traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network	PE1	18
+NX_Q99748	Neurturin	197	22405	10.92	0	Golgi apparatus;Secreted	NA	Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.	NA	Belongs to the TGF-beta family. GDNF subfamily.	RAF/MAP kinase cascade;NCAM1 interactions;RET signaling	PE1	19
+NX_Q99750	MyoD family inhibitor	246	25029	4.29	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity).	NA	Belongs to the MDFI family.	NA	PE1	6
+NX_Q99755	Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	562	62633	8.41	0	Cytoplasm;Nucleus speckle;Cell membrane;Lamellipodium;Ruffle;Nucleus	NA	Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197, PubMed:19158393, PubMed:20660631). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity).	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Endocytosis;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Synthesis of PIPs at the plasma membrane;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	1
+NX_Q99757	Thioredoxin, mitochondrial	166	18383	8.46	0	Mitochondrion	Combined oxidative phosphorylation deficiency 29	Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.	NA	Belongs to the thioredoxin family.	Detoxification of Reactive Oxygen Species;Degradation of cysteine and homocysteine	PE1	22
+NX_Q99758	ATP-binding cassette sub-family A member 3	1704	191362	7.55	14	Membrane;Nucleoplasm;Cytosol	Pulmonary surfactant metabolism dysfunction 3	Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.	NA	Belongs to the ABC transporter superfamily. ABCA family.	ABC transporters;ABC transporters in lipid homeostasis;Surfactant metabolism;Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3);Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)	PE1	16
+NX_Q99759	Mitogen-activated protein kinase kinase kinase 3	626	70898	8.98	0	Cytoplasm;Nucleoplasm	NA	Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.	Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity.;MAP3K3 is phosphorylated by WNK1	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway;Neurotrophin signaling pathway;GnRH signaling pathway;HTLV-I infection;Interleukin-1 signaling	PE1	17
+NX_Q99766	ATP synthase subunit s, mitochondrial	215	24866	7.51	0	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.	NA	Belongs to the ATP synthase subunit s family.	Formation of ATP by chemiosmotic coupling;Cristae formation	PE1	14
+NX_Q99767	Amyloid-beta A4 precursor protein-binding family A member 2	749	82512	4.77	0	Golgi apparatus	NA	Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.	NA	NA	Neurexins and neuroligins	PE1	15
+NX_Q99784	Noelin	485	55343	6.48	0	Perikaryon;Secreted;Nucleolus;Endoplasmic reticulum;Nucleoplasm;Synapse;Cytosol;Axon	NA	Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity).	NA	NA	NA	PE1	9
+NX_Q99788	Chemokine-like receptor 1	373	42322	8.71	7	Cell membrane	NA	Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).	NA	Belongs to the G-protein coupled receptor 1 family.	Class A/1 (Rhodopsin-like receptors)	PE1	12
+NX_Q99795	Cell surface A33 antigen	319	35632	4.85	1	Membrane	NA	May play a role in cell-cell recognition and signaling.	N-glycosylated, contains approximately 8 kDa of N-linked carbohydrate.;Palmitoylated.	NA	NA	PE1	1
+NX_Q99797	Mitochondrial intermediate peptidase	713	80641	6.6	0	Mitochondrion matrix;Mitochondrion	Combined oxidative phosphorylation deficiency 31	Cleaves proteins, imported into the mitochondrion, to their mature size.	NA	Belongs to the peptidase M3 family.	NA	PE1	13
+NX_Q99798	Aconitate hydratase, mitochondrial	780	85425	7.36	0	Mitochondrion	Infantile cerebellar-retinal degeneration;Optic atrophy 9	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.	NA	Belongs to the aconitase/IPM isomerase family.	Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.;Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Mitochondrial protein import;Citric acid cycle (TCA cycle)	PE1	22
+NX_Q99801	Homeobox protein Nkx-3.1	234	26350	9.23	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.	Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.	Belongs to the NK-3 homeobox family.	Pathways in cancer;Prostate cancer	PE1	8
+NX_Q99805	Transmembrane 9 superfamily member 2	663	75776	7.22	9	Cytoplasm;Endosome membrane;Cell membrane	NA	In the intracellular compartments, may function as a channel or small molecule transporter.	NA	Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	NA	PE1	13
+NX_Q99807	5-demethoxyubiquinone hydroxylase, mitochondrial	217	24277	8.77	0	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion;Cell membrane	Coenzyme Q10 deficiency, primary, 8	Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.	NA	Belongs to the COQ7 family.	Cofactor biosynthesis; ubiquinone biosynthesis.;Ubiquinone and other terpenoid-quinone biosynthesis;Metabolic pathways;Ubiquinol biosynthesis	PE1	16
+NX_Q99808	Equilibrative nucleoside transporter 1	456	50219	8.62	11	Basolateral cell membrane;Apical cell membrane;Cell membrane	NA	Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).	Glycosylated.	Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	PE1	6
+NX_Q99811	Paired mesoderm homeobox protein 2	253	27079	10.15	0	Nucleoplasm;Nucleus	NA	May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.	NA	Belongs to the paired homeobox family.	NA	PE1	9
+NX_Q99814	Endothelial PAS domain-containing protein 1	870	96459	5.87	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleus	Erythrocytosis, familial, 4	Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).	In normoxia, is hydroxylated on Asn-847 by HIF1AN thus probably abrogating interaction with CREBBP and EP300 and preventing transcriptional activation.;The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains.;In normoxia, is probably hydroxylated on Pro-405 and Pro-531 by EGLN1/PHD1, EGLN2/PHD2 and/or EGLN3/PHD3. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization (By similarity).;Phosphorylated on multiple sites in the CTAD.	NA	Pathways in cancer;Renal cell carcinoma;Transcriptional regulation of pluripotent stem cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Regulation of gene expression by Hypoxia-inducible Factor;PTK6 Expression;Neddylation;Cellular response to hypoxia	PE1	2
+NX_Q99816	Tumor susceptibility gene 101 protein	390	43944	6.06	0	Cytoplasm;Cell membrane;Nucleolus;Late endosome membrane;Centrosome;Early endosome membrane;Cytosol;Nucleus;Midbody ring	NA	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426).	Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1.	Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.	Endocytosis;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	11
+NX_Q99819	Rho GDP-dissociation inhibitor 3	225	25098	5.45	0	Cytoplasm;Cytosol;Cell membrane	NA	Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.	NA	Belongs to the Rho GDI family.	Rho GTPase cycle	PE1	16
+NX_Q99828	Calcium and integrin-binding protein 1	191	21703	4.65	0	trans-Golgi network;Cytoplasm;Filopodium tip;Perinuclear region;Cell membrane;Neuron projection;Growth cone;Perikaryon;Membrane;Nucleoplasm;Lamellipodium;Centrosome;Ruffle membrane;Apical cell membrane;Sarcolemma;Nucleus;Cytoskeleton	Epidermodysplasia verruciformis 3	(Microbial infection) Involved in keratinocyte-intrinsic immunity to human beta-papillomaviruses (HPVs).;Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion.;Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.	Phosphorylation of isoform 2 at Ser-118 by PRKD2 increases its ability to stimulate tumor angiogenesis.	NA	NA	PE1	15
+NX_Q99829	Copine-1	537	59059	5.52	0	Cytoplasm;Cell membrane;Nucleus membrane;Nucleoplasm;Nucleus	NA	Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).	NA	Belongs to the copine family.	Glycerophospholipid biosynthesis;Neutrophil degranulation	PE1	20
+NX_Q99832	T-complex protein 1 subunit eta	543	59367	7.55	0	Cytoplasm;Cytosol	NA	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable).	NA	Belongs to the TCP-1 chaperonin family.	Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	PE1	2
+NX_Q99835	Smoothened homolog	787	86397	8.71	7	Membrane;Cilium	Curry-Jones syndrome	G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).	SMO is phosphorylated by CSNK1A1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the G-protein coupled receptor Fz/Smo family.	Hedgehog signaling pathway;Pathways in cancer;Basal cell carcinoma;Hedgehog 'on' state;BBSome-mediated cargo-targeting to cilium;Class B/2 (Secretin family receptors);Hedgehog 'off' state;Activation of SMO	PE1	7
+NX_Q99836	Myeloid differentiation primary response protein MyD88	296	33233	5.89	0	Cytoplasm;Mitochondrion;Cytoplasmic vesicle;Cytosol;Nucleus	MYD88 deficiency	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).	Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.	NA	Apoptosis;Toll-like receptor signaling pathway;Salmonella infection;Pertussis;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);African trypanosomiasis;Malaria;Toxoplasmosis;Tuberculosis;Measles;Influenza A;Herpes simplex infection;ER-Phagosome pathway;PIP3 activates AKT signaling;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;RIP-mediated NFkB activation via ZBP1;p75NTR recruits signalling complexes;DEx/H-box helicases activate type I IFN and inflammatory cytokines production;MyD88 deficiency (TLR2/4);MyD88 deficiency (TLR5);IRAK4 deficiency (TLR5);IRAK4 deficiency (TLR2/4);TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 dependent cascade initiated on endosome;MyD88 cascade initiated on plasma membrane;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-1 signaling	PE1	3
+NX_Q99848	Probable rRNA-processing protein EBP2	306	34852	10.1	0	Nucleolus	NA	Required for the processing of the 27S pre-rRNA.	NA	Belongs to the EBP2 family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	1
+NX_Q99853	Forkhead box protein B1	325	34978	9.66	0	Nucleoplasm;Mitochondrion;Nucleus	NA	NA	NA	NA	NA	PE1	15
+NX_Q99856	AT-rich interactive domain-containing protein 3A	593	62889	4.84	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.	NA	NA	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	PE1	19
+NX_Q99865	Spindlin-2A	258	29188	6.72	0	Nucleus	NA	May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846).	NA	Belongs to the SPIN/STSY family.	NA	PE1	X
+NX_Q99871	HAUS augmin-like complex subunit 7	368	40778	4.73	0	Cytoplasm;Cell membrane;Nucleolus;Centrosome;Cytosol;Spindle;Nucleus	NA	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.	NA	Belongs to the HAUS7 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	X
+NX_Q99873	Protein arginine N-methyltransferase 1	371	42462	5.18	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:10749851, PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).	Polyubiquitinated at Lys-145 by the SCF(FBXL17) complex, leading to its subsequent degradation. Ubiquitination is regulated by acetylation at Lys-228 and Lys-233.;Acetylation at Lys-228 and Lys-233 regulates ubiquitination by the SCF(FBXL17) complex. Acetylated at Lys-233 by p300/EP300. Deacetylated at Lys-228 and Lys-233 by SIRT1.	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	RMTs methylate histone arginines;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Extra-nuclear estrogen signaling	PE1	19
+NX_Q99877	Histone H2B type 1-N	126	13922	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.;GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_Q99878	Histone H2A type 1-J	128	13936	10.88	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).;Deiminated on Arg-4 in granulocytes upon calcium entry.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.;Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.;Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.	Belongs to the histone H2A family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;RMTs methylate histone arginines;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_Q99879	Histone H2B type 1-M	126	13989	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.;GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).;Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;ADP-ribosylated on Ser-7 in response to DNA damage.	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_Q99880	Histone H2B type 1-L	126	13952	10.31	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).;Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.;ADP-ribosylated on Ser-7 in response to DNA damage.;Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.;Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.	Belongs to the histone H2B family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;HATs acetylate histones;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Amyloid fiber formation;Pre-NOTCH Transcription and Translation;G2/M DNA damage checkpoint;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Ub-specific processing proteases;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	6
+NX_Q99884	Sodium-dependent proline transporter	636	70911	6.22	12	Membrane;Cytoplasm;Cell membrane	NA	Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily.	Na+/Cl- dependent neurotransmitter transporters;Creatine metabolism	PE1	5
+NX_Q99895	Chymotrypsin-C	268	29484	7.54	0	NA	Pancreatitis, hereditary	Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.	NA	Belongs to the peptidase S1 family. Elastase subfamily.	Cobalamin (Cbl, vitamin B12) transport and metabolism	PE1	1
+NX_Q99909	Protein SSX3	188	21697	8.82	0	NA	NA	Could act as a modulator of transcription.	NA	Belongs to the SSX family.	NA	PE1	X
+NX_Q99928	Gamma-aminobutyric acid receptor subunit gamma-3	467	54289	7.46	4	Postsynaptic cell membrane;Cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	May be palmitoylated.	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;Signaling by ERBB4;GABA receptor activation	PE2	15
+NX_Q99929	Achaete-scute homolog 2	193	20185	11.18	0	Nucleus	NA	AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.	NA	NA	NA	PE1	11
+NX_Q99932	Sperm-associated antigen 8	485	51139	5.63	0	Cytoplasm;Microtubule organizing center;Spindle;Nucleus;Acrosome	NA	Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252).	NA	Belongs to the SPAG8 family.	NA	PE1	9
+NX_Q99933	BAG family molecular chaperone regulator 1	345	38779	7.68	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).	Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.	NA	Protein processing in endoplasmic reticulum;Regulation of HSF1-mediated heat shock response	PE1	9
+NX_Q99935	Opiorphin prepropeptide	248	27217	10.42	0	Secreted	NA	Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection.	NA	Belongs to the PROL1/PROL3 family.	NA	PE1	4
+NX_Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	703	76709	5.9	1	Nucleoplasm;Nucleus;Endoplasmic reticulum membrane;Nucleolus	NA	Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.	N-glycosylated.;During unfolded protein response, a fragment of approximately 60 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.	Belongs to the bZIP family. ATF subfamily.	Protein processing in endoplasmic reticulum;Dopaminergic synapse	PE1	6
+NX_Q99942	E3 ubiquitin-protein ligase RNF5	180	19881	6.2	2	Mitochondrion membrane;Endoplasmic reticulum;Membrane;Endoplasmic reticulum membrane	NA	Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses.	NA	NA	Protein modification; protein ubiquitination.;Protein processing in endoplasmic reticulum;ER Quality Control Compartment (ERQC);ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis	PE1	6
+NX_Q99943	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha	283	31717	9.48	2	Endoplasmic reticulum;Cytoplasm;Endoplasmic reticulum membrane	NA	Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.;Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Fat digestion and absorption;Synthesis of PA;ChREBP activates metabolic gene expression	PE1	6
+NX_Q99944	Epidermal growth factor-like protein 8	293	32262	6.37	0	Cytoplasmic vesicle;Nucleus speckle;Secreted	NA	NA	NA	NA	NA	PE1	6
+NX_Q99946	Proline-rich transmembrane protein 1	306	31430	7.26	2	Synapse;Cell membrane	NA	NA	NA	Belongs to the CD225/Dispanin family.	NA	PE1	6
+NX_Q99952	Tyrosine-protein phosphatase non-receptor type 18	460	50482	8.57	0	Cytoplasm;Nucleus;Cytoskeleton	NA	Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.	Downregulation of ERBB2 signaling;Interleukin-37 signaling	PE1	2
+NX_Q99954	Submaxillary gland androgen-regulated protein 3A	134	14048	9.62	0	Secreted	NA	May play a role in protection or detoxification.	NA	Belongs to the PROL1/PROL3 family.	NA	PE1	4
+NX_Q99956	Dual specificity protein phosphatase 9	384	41868	5.8	0	Endoplasmic reticulum;Cytoplasm	NA	Inactivates MAP kinases. Has a specificity for the ERK family.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway;RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway	PE1	X
+NX_Q99958	Forkhead box protein C2	501	53719	8.68	0	Nucleoplasm;Nucleus	Lymphedema-distichiasis syndrome	Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.	Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin.	NA	NA	PE1	16
+NX_Q99959	Plakophilin-2	881	97415	9.39	0	Nucleoplasm;Cell junction;Desmosome;Nucleus	Arrhythmogenic right ventricular dysplasia, familial, 9	May play a role in junctional plaques.	NA	Belongs to the beta-catenin family.	Arrhythmogenic right ventricular cardiomyopathy (ARVC);Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q99961	Endophilin-A2	368	41490	5.31	0	Early endosome membrane;Cytoplasm;Cytosol;Podosome	NA	Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).	NA	Belongs to the endophilin family.	Endocytosis;EGFR downregulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Negative regulation of MET activity;InlB-mediated entry of Listeria monocytogenes into host cell	PE1	19
+NX_Q99962	Endophilin-A1	352	39962	5.32	0	Cytoplasm;Early endosome;Membrane;Presynapse;Spindle;Cytoskeleton	NA	Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.	NA	Belongs to the endophilin family.	Endocytosis;MHC class II antigen presentation;Golgi Associated Vesicle Biogenesis;Retrograde neurotrophin signalling;EGFR downregulation;Lysosome Vesicle Biogenesis;Recycling pathway of L1;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Negative regulation of MET activity;InlB-mediated entry of Listeria monocytogenes into host cell	PE1	9
+NX_Q99963	Endophilin-A3	347	39285	5.27	0	Early endosome membrane;Cytoplasm;Mitochondrion	NA	Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).	NA	Belongs to the endophilin family.	Endocytosis;EGFR downregulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Negative regulation of MET activity;InlB-mediated entry of Listeria monocytogenes into host cell	PE1	15
+NX_Q99965	Disintegrin and metalloproteinase domain-containing protein 2	735	82457	5.77	1	Membrane	NA	Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.	The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.	NA	Interaction With Cumulus Cells And The Zona Pellucida	PE1	8
+NX_Q99966	Cbp/p300-interacting transactivator 1	193	19896	4.63	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.	Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity.	Belongs to the CITED family.	Activation of the TFAP2 (AP-2) family of transcription factors;Estrogen-dependent gene expression	PE1	X
+NX_Q99967	Cbp/p300-interacting transactivator 2	270	28497	6.42	0	Nucleoplasm;Nucleus	Ventricular septal defect 2;Atrial septal defect 8	Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.	NA	Belongs to the CITED family.	Regulation of gene expression by Hypoxia-inducible Factor;Activation of the TFAP2 (AP-2) family of transcription factors;TFAP2 (AP-2) family regulates transcription of other transcription factors;FOXO-mediated transcription of cell death genes	PE1	6
+NX_Q99969	Retinoic acid receptor responder protein 2	163	18618	9.3	0	Secreted	NA	Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.	Secreted in an inactive precursor form, prochemerin, which is proteolytically processed by a variety of extracellular proteases to generate forms with differing levels of bioactivity. For example, the removal of six amino acids results in chemerin-157, which exhibits the highest activity, while removal of seven amino acids results in chemerin-156 which has slightly less activity. Some proteases are able to cleave at more than one site and chemerin forms may be sequentially processed by different enzymes to modulate activity levels. The coordinated expression and activity of chemerin-modifying enzymes is essential for regulating its bioactivation, inactivation and, consequently, biological function. Cathepsin G cleaves seven C-terminal amino acids from prochemerin (chemerin-156), elastase is able to cleave six (chemerin-157), eight (chemerin-155) or eleven (chemerin-152), plasmin cleaves five amino acids (chemerin-158), and tryptase cleaves five (chemerin-158) or eight (chemerin-155). Multiple cleavages might be required to fully activate chemerin, with an initial tryptase cleavage resulting in chemerin with low activity (chemerin-158), and a second cleavage by carboxypeptidase N or B producing highly active chemerin (chemerin-157).	NA	Platelet degranulation	PE1	7
+NX_Q99972	Myocilin	504	56972	5.44	0	Mitochondrion outer membrane;Extracellular exosome;Golgi apparatus;Mitochondrion;Extracellular matrix;Mitochondrion intermembrane space;Cell projection;Secreted;Cilium;Rough endoplasmic reticulum;Endoplasmic reticulum;Extracellular space;Cytoplasmic vesicle;Mitochondrion inner membrane	Glaucoma 3, primary congenital, A;Glaucoma 1, open angle, A	Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.	Glycosylated.;Palmitoylated.;Undergoes a calcium-dependent proteolytic cleavage at Arg-226 by CAPN2 in the endoplasmic reticulum. The result is the production of two fragments, one of 35 kDa containing the C-terminal olfactomedin-like domain, and another of 20 kDa containing the N-terminal leucine zipper-like domain.;Different isoforms may arise by post-translational modifications.	NA	NA	PE1	1
+NX_Q99973	Telomerase protein component 1	2627	290490	8.26	0	Cytoplasmic vesicle;Nucleoplasm;Telomere;Nucleus	NA	Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).	NA	NA	NA	PE1	14
+NX_Q99983	Osteomodulin	421	49492	5.34	0	Endoplasmic reticulum;Extracellular matrix;Nucleolus	NA	May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	Binds keratan sulfate chains.	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Keratan sulfate biosynthesis;Defective CHST6 causes MCDC1;Keratan sulfate degradation;Defective B4GALT1 causes B4GALT1-CDG (CDG-2d);Defective ST3GAL3 causes MCT12 and EIEE15	PE1	9
+NX_Q99985	Semaphorin-3C	751	85207	8.96	0	Golgi apparatus;Cytosol;Secreted;Cell membrane	NA	Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).	NA	Belongs to the semaphorin family.	Axon guidance	PE1	7
+NX_Q99986	Serine/threonine-protein kinase VRK1	396	45476	9.02	0	Cytoplasm;Nucleoplasm;Cytosol;Spindle;Nucleus	Pontocerebellar hypoplasia 1A	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.	Autophosphorylated at various serine and threonine residues. Autophosphorylation does not impair its ability to phosphorylate p53/TP53. Phosphorylation by PLK3 leads to induction of Golgi fragmentation during mitosis.	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.	Initiation of Nuclear Envelope Reformation;Nuclear Envelope Breakdown	PE1	14
+NX_Q99988	Growth/differentiation factor 15	308	34140	9.79	0	Golgi apparatus;Secreted	NA	Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).	NA	Belongs to the TGF-beta family.	NA	PE1	19
+NX_Q99990	Transcription cofactor vestigial-like protein 1	258	28707	9.26	0	Nucleoplasm;Nucleus	NA	May act as a specific coactivator for the mammalian TEFs.	NA	Belongs to the vestigial family.	NA	PE1	X
+NX_Q99996	A-kinase anchor protein 9	3907	452987	4.95	0	Golgi apparatus;Cytoplasm;Centrosome;Cytoplasmic vesicle	Long QT syndrome 11	Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations.;Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697).	NA	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2;Phase 3 - rapid repolarisation;Phase 2 - plateau phase;Signaling by BRAF and RAF fusions	PE1	7
+NX_Q99999	Galactosylceramide sulfotransferase	423	48764	8.84	1	Cytoplasmic vesicle;Golgi apparatus membrane	NA	Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).	NA	Belongs to the galactose-3-O-sulfotransferase family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways	PE1	22
+NX_Q9BPU6	Dihydropyrimidinase-related protein 5	564	61421	6.73	0	Nucleoplasm;Cytosol;Cytoplasm	NA	May have a function in neuronal differentiation and/or axon growth.	NA	Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.	Axon guidance;CRMPs in Sema3A signaling	PE1	2
+NX_Q9BPU9	B9 domain-containing protein 2	175	19261	7.14	0	Cilium basal body;Cilium axoneme;Nucleus	Meckel syndrome 10;Joubert syndrome 34	Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.	NA	Belongs to the B9D family.	Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	19
+NX_Q9BPV8	P2Y purinoceptor 13	354	40789	9.94	7	Cell membrane	NA	Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;P2Y receptors	PE1	3
+NX_Q9BPW4	Apolipoprotein L4	351	39164	7.78	0	Cytoplasmic vesicle;Secreted	NA	May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).	NA	Belongs to the apolipoprotein L family.	NA	PE1	22
+NX_Q9BPW5	Ras-like protein family member 11B	248	27508	9.28	0	Nucleus	NA	NA	NA	Belongs to the small GTPase superfamily. Ras family.	NA	PE2	4
+NX_Q9BPW8	Protein NipSnap homolog 1	284	33310	9.35	0	NA	NA	NA	NA	Belongs to the NipSnap family.	NA	PE1	22
+NX_Q9BPW9	Dehydrogenase/reductase SDR family member 9	319	35227	8.78	0	Microsome membrane;Endoplasmic reticulum membrane	NA	3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed:11294878, PubMed:29541409). Plays also a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:11304534, PubMed:12618084). Can utilize both NADH and NADPH.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Retinol metabolism;Metabolic pathways;The canonical retinoid cycle in rods (twilight vision);RA biosynthesis pathway	PE1	2
+NX_Q9BPX1	17-beta-hydroxysteroid dehydrogenase 14	270	28317	5.8	0	Cytoplasm	NA	Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Estrogen biosynthesis	PE1	19
+NX_Q9BPX3	Condensin complex subunit 3	1015	114334	5.44	0	Cytoplasm;Nucleus;Chromosome	NA	Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.	Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPH subunits, activates the condensin complex and is required for chromosome condensation (By similarity).	Belongs to the CND3 (condensin subunit 3) family.	Condensation of Prometaphase Chromosomes	PE1	4
+NX_Q9BPX5	Actin-related protein 2/3 complex subunit 5-like protein	153	16941	6.15	0	Cytoskeleton	NA	May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	NA	Belongs to the ARPC5 family.	Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection	PE1	9
+NX_Q9BPX6	Calcium uptake protein 1, mitochondrial	476	54351	8.61	1	Mitochondrion intermembrane space;Mitochondrion;Mitochondrion inner membrane	Myopathy with extrapyramidal signs	Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).	NA	Belongs to the MICU1 family. MICU1 subfamily.	Processing of SMDT1;Mitochondrial calcium ion transport	PE1	10
+NX_Q9BPX7	UPF0415 protein C7orf25	421	46451	6	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the UPF0415 family.	NA	PE1	7
+NX_Q9BPY3	Protein FAM118B	351	39499	5.65	0	Cajal body	NA	May play a role in Cajal bodies formation.	NA	Belongs to the FAM118 family.	NA	PE1	11
+NX_Q9BPY8	Homeodomain-only protein	73	8260	4.8	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256).	NA	NA	NA	PE1	4
+NX_Q9BPZ2	Spindlin-2B	258	29158	6.72	0	Nucleus	NA	Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846).	NA	Belongs to the SPIN/STSY family.	NA	PE1	X
+NX_Q9BPZ3	Polyadenylate-binding protein-interacting protein 2	127	14984	4.03	0	Cytoplasm;Cytoplasmic vesicle	NA	Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.	Ubiquitinated, leading to its degradation by the proteasome.	Belongs to the PAIP2 family.	NA	PE1	5
+NX_Q9BPZ7	Target of rapamycin complex 2 subunit MAPKAP1	522	59123	7.24	0	Cell membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. MTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. MTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. MTORC2 promotes the serum-induced formation of stress-fibers or F-actin. MTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. MTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. MTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.	NA	Belongs to the SIN1 family.	PIP3 activates AKT signaling;VEGFR2 mediated vascular permeability;CD28 dependent PI3K/Akt signaling;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation	PE1	9
+NX_Q9BQ04	RNA-binding protein 4B	359	40150	6.28	0	Nucleolus;Nucleus	NA	Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity).	NA	NA	NA	PE1	11
+NX_Q9BQ08	Resistin-like beta	111	11730	7.44	0	Secreted	NA	Probable hormone.	NA	Belongs to the resistin/FIZZ family.	NA	PE2	3
+NX_Q9BQ13	BTB/POZ domain-containing protein KCTD14	255	29591	8.78	0	Nucleoplasm;Cytosol;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	11
+NX_Q9BQ15	SOSS complex subunit B1	211	22338	9.17	0	Nucleoplasm;Nucleus	NA	Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.	Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells.	Belongs to the SOSS-B family. SOSS-B1 subfamily.	RNA polymerase II transcribes snRNA genes	PE1	12
+NX_Q9BQ16	Testican-3	436	49429	4.79	0	Extracellular matrix	NA	May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.	Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.	NA	Activation of Matrix Metalloproteinases	PE1	4
+NX_Q9BQ24	Zinc finger FYVE domain-containing protein 21	234	26506	8.78	0	Cytoplasm;Endosome;Focal adhesion;Cytoplasmic vesicle	NA	Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression.	NA	NA	NA	PE1	14
+NX_Q9BQ31	Potassium voltage-gated channel subfamily S member 3	491	56001	4.92	6	Golgi apparatus;Cytosol;Cell membrane	NA	Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).	NA	Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.	Voltage gated Potassium channels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	PE1	2
+NX_Q9BQ39	ATP-dependent RNA helicase DDX50	737	82565	9.26	0	Nucleolus	NA	NA	NA	Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.	NA	PE1	10
+NX_Q9BQ48	39S ribosomal protein L34, mitochondrial	92	10165	12.25	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bL34 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	19
+NX_Q9BQ49	Small integral membrane protein 7	75	8631	7.9	1	Membrane;Golgi apparatus	NA	NA	NA	Belongs to the SMIM7 family.	NA	PE1	19
+NX_Q9BQ50	Three prime repair exonuclease 2	236	25922	5.68	0	Nucleus	NA	Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair.	NA	Belongs to the exonuclease superfamily. TREX family.	NA	PE1	X
+NX_Q9BQ51	Programmed cell death 1 ligand 2	273	30957	8.18	1	Cell membrane;Endomembrane system;Secreted;Cytosol	NA	Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).	NA	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Cell adhesion molecules (CAMs);PD-1 signaling	PE1	9
+NX_Q9BQ52	Zinc phosphodiesterase ELAC protein 2	826	92219	8.13	0	Nucleoplasm;Mitochondrion;Nucleus	Prostate cancer, hereditary, 2;Combined oxidative phosphorylation deficiency 17	Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.	NA	Belongs to the RNase Z family.	RNA transport;tRNA processing in the nucleus;tRNA processing in the mitochondrion;rRNA processing in the mitochondrion	PE1	17
+NX_Q9BQ61	Telomerase RNA component interacting RNase	176	18419	9.46	0	Nucleoplasm;Nucleus	NA	Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335).	NA	NA	NA	PE1	19
+NX_Q9BQ65	U6 snRNA phosphodiesterase	265	30268	6.06	0	Nucleoplasm;Nucleus	Poikiloderma with neutropenia	Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.	NA	Belongs to the 2H phosphoesterase superfamily. USB1 family.	NA	PE1	16
+NX_Q9BQ66	Keratin-associated protein 4-12	201	21407	8.37	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 4 family.	NA	PE1	17
+NX_Q9BQ67	Glutamate-rich WD repeat-containing protein 1	446	49419	4.82	0	Nucleoplasm;Nucleolus;Nucleus;Chromosome	NA	Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725).	NA	NA	NA	PE1	19
+NX_Q9BQ69	ADP-ribose glycohydrolase MACROD1	325	35505	9.58	0	Nucleoplasm;Nucleus	NA	Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710). Enhances ESR1-mediated transcription activity (PubMed:17914104).	NA	NA	NA	PE1	11
+NX_Q9BQ70	Transcription factor 25	676	76667	5.96	0	Nucleus	NA	May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.	NA	Belongs to the TCF25 family.	NA	PE1	16
+NX_Q9BQ75	Protein CMSS1	279	31884	9.26	0	Mitochondrion;Nucleolus;Nucleus membrane;Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the CMS1 family.	NA	PE1	3
+NX_Q9BQ83	Structure-specific endonuclease subunit SLX1	275	30771	6.59	0	Nucleoplasm;Nucleus	NA	Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.	NA	Belongs to the SLX1 family.	Fanconi anemia pathway;Fanconi anemia pathway;Resolution of D-loop Structures through Holliday Junction Intermediates;Fanconi Anemia Pathway	PE1	16
+NX_Q9BQ87	F-box-like/WD repeat-containing protein TBL1Y	522	56688	5.33	0	Nucleus	Deafness, Y-linked 2	F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).	NA	Belongs to the WD repeat EBI family.	Wnt signaling pathway	PE1	Y
+NX_Q9BQ89	Protein FAM110A	295	31271	10.46	0	Cytoplasm;Nucleoplasm;Spindle pole;Centrosome;Cytoplasmic vesicle;Cytosol	NA	NA	NA	Belongs to the FAM110 family.	NA	PE1	20
+NX_Q9BQ90	Kelch domain-containing protein 3	382	43088	8.37	0	Cytoplasm;Nucleoplasm	NA	May be involved in meiotic recombination process.	NA	NA	XBP1(S) activates chaperone genes	PE1	6
+NX_Q9BQ95	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial	431	49148	5.89	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	NA	Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.;Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).	NA	Belongs to the ECSIT family.	MAPK signaling pathway;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 cascade initiated on plasma membrane;Complex I biogenesis	PE1	19
+NX_Q9BQA1	Methylosome protein 50	342	36724	5.03	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol;Nucleus	NA	Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).	NA	NA	RMTs methylate histone arginines;snRNP Assembly	PE1	1
+NX_Q9BQA5	Histone H4 transcription factor	517	59678	5.77	0	Nucleus	NA	Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.	Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation.	NA	NA	PE1	11
+NX_Q9BQA9	Cytochrome b-245 chaperone 1	187	20774	6.3	1	Cell junction;Endoplasmic reticulum membrane;Cell membrane	NA	Necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer. Controls the phagocyte respiratory burst and is essential for innate immunity.	NA	Belongs to the CYBC1 family.	NA	PE1	17
+NX_Q9BQB4	Sclerostin	213	24031	9.43	0	Extracellular matrix	Van Buchem disease;Sclerosteosis 1;Craniodiaphyseal dysplasia autosomal dominant	Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.	NA	Belongs to the sclerostin family.	TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists	PE1	17
+NX_Q9BQB6	Vitamin K epoxide reductase complex subunit 1	163	18235	9.53	4	Endoplasmic reticulum;Endoplasmic reticulum membrane	Combined deficiency of vitamin K-dependent clotting factors 2;Coumarin resistance	Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.	NA	Belongs to the VKOR family.	Metabolism of vitamin K	PE1	16
+NX_Q9BQC3	2-(3-amino-3-carboxypropyl)histidine synthase subunit 2	489	52083	5.36	0	Nucleoplasm	NA	Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).	NA	Belongs to the DPH1/DPH2 family. DPH2 subfamily.	Protein modification; peptidyl-diphthamide biosynthesis.;Synthesis of diphthamide-EEF2	PE1	1
+NX_Q9BQC6	Ribosomal protein 63, mitochondrial	102	12266	11.45	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL63 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	13
+NX_Q9BQD1	Putative pro-MCH-like protein 2	86	9856	8.66	0	NA	NA	NA	NA	Belongs to the melanin-concentrating hormone family.	NA	PE5	5
+NX_Q9BQD3	KxDL motif-containing protein 1	176	19668	4.79	0	Cytosol;Lysosome membrane;Centrosome;Nucleolus	NA	As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity).	NA	Belongs to the KXD1 family.	NA	PE1	19
+NX_Q9BQD7	Adenine nucleotide translocase lysine N-methyltransferase	235	25130	9.45	1	Mitochondrion membrane;Cytosol	NA	Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526).	NA	Belongs to the ANT/ATPSC lysine N-methyltransferase family.	NA	PE1	16
+NX_Q9BQE3	Tubulin alpha-1C chain	449	49895	4.96	0	Cytoplasm;Cytoskeleton	NA	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Tubulin alpha-1C chain: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules (PubMed:26972003). In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).;Detyrosinated tubulin alpha-1C chain: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).;Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.;Nitration of Tyr-449 is irreversible and interferes with normal dynein intracellular distribution.;Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	12
+NX_Q9BQE4	Selenoprotein S	189	21163	9.72	1	Endoplasmic reticulum;Cytoplasm;Endoplasmic reticulum membrane	NA	Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.	NA	Belongs to the selenoprotein S family.	Protein processing in endoplasmic reticulum;E3 ubiquitin ligases ubiquitinate target proteins	PE1	15
+NX_Q9BQE5	Apolipoprotein L2	337	37092	6.28	0	Cytoplasm	NA	May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	NA	Belongs to the apolipoprotein L family.	NA	PE1	22
+NX_Q9BQE6	LBH domain-containing protein 1	289	31565	4.52	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_Q9BQE9	B-cell CLL/lymphoma 7 protein family member B	202	22195	4.67	0	Nucleoplasm	NA	Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity).	NA	Belongs to the BCL7 family.	NA	PE1	7
+NX_Q9BQF6	Sentrin-specific protease 7	1050	119658	6.19	0	Nucleoplasm;Cytosol	NA	Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.	NA	Belongs to the peptidase C48 family.	NA	PE1	3
+NX_Q9BQG0	Myb-binding protein 1A	1328	148855	9.34	0	Cytoplasmic vesicle;Nucleus;Cytoplasm;Nucleolus	NA	May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309).	Citrullinated by PADI4.	Belongs to the MYBBP1A family.	B-WICH complex positively regulates rRNA expression	PE1	17
+NX_Q9BQG1	Synaptotagmin-3	590	63304	6.16	1	Secretory vesicle membrane;Cell membrane	NA	Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).	NA	Belongs to the synaptotagmin family.	NA	PE1	19
+NX_Q9BQG2	Peroxisomal NADH pyrophosphatase NUDT12	462	52076	6.38	0	Peroxisome;Cytoplasm;Nucleus	NA	Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.	NA	Belongs to the Nudix hydrolase family. NudC subfamily.	Nicotinate and nicotinamide metabolism;Peroxisome;Nicotinamide salvaging	PE1	5
+NX_Q9BQI0	Allograft inflammatory factor 1-like	150	17068	6.63	0	Ruffle membrane;Cytoskeleton	NA	Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.	NA	NA	NA	PE1	9
+NX_Q9BQI3	Eukaryotic translation initiation factor 2-alpha kinase 1	630	71106	5.68	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions (By similarity).	Activated by autophosphorylation; phosphorylated predominantly on serine and threonine residues, but also on tyrosine residues. Autophosphorylation at Thr-488 is required for kinase activation. The active autophosphorylated form apparently is largely refractory to cellular heme fluctuations (By similarity).	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.	Protein processing in endoplasmic reticulum;Hepatitis C;Measles;Influenza A;Herpes simplex infection	PE1	7
+NX_Q9BQI4	Coiled-coil domain-containing protein 3	270	30731	8.95	0	Endoplasmic reticulum;Nucleoplasm;Secreted;Cytosol	NA	Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity).	NA	NA	NA	PE1	10
+NX_Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	828	89109	8.39	0	Cytoplasm;Mitochondrion;Clathrin-coated pit	NA	May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.	NA	NA	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	1
+NX_Q9BQI6	SMC5-SMC6 complex localization factor protein 1	1058	121050	8.7	0	Nucleoplasm;Cytoplasm;Centrosome;Nucleus	NA	Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).	NA	NA	NA	PE1	5
+NX_Q9BQI7	PH and SEC7 domain-containing protein 2	771	84660	5.04	1	Ruffle membrane;Cleavage furrow;Cell membrane	NA	NA	NA	Belongs to the PSD family.	Endocytosis	PE1	5
+NX_Q9BQI9	Nuclear receptor-interacting protein 2	281	31331	8.75	0	Nucleoplasm;Cytosol;Nucleus	NA	Down-regulates transcriptional activation by nuclear receptors such as NR1F2.	NA	NA	NA	PE1	12
+NX_Q9BQJ4	Transmembrane protein 47	181	19998	6.26	4	Membrane;Adherens junction;Nucleus membrane;Cell membrane	NA	Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity).	NA	Belongs to the TMEM47 family.	NA	PE1	X
+NX_Q9BQK8	Phosphatidate phosphatase LPIN3	851	93614	5.35	0	Cytosol;Nucleus	NA	Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis (By similarity).	NA	Belongs to the lipin family.	Synthesis of PC;Synthesis of PE;Triglyceride biosynthesis;Depolymerisation of the Nuclear Lamina	PE1	20
+NX_Q9BQL6	Fermitin family homolog 1	677	77437	5.91	0	Ruffle membrane;Focal adhesion;Cytoskeleton	Kindler syndrome	Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.	NA	Belongs to the kindlin family.	NA	PE1	20
+NX_Q9BQM9	Uncharacterized protein C20orf144	153	17214	11.47	0	NA	NA	NA	NA	NA	NA	PE1	20
+NX_Q9BQN1	Protein FAM83C	747	81078	8.28	0	NA	NA	May play a role in MAPK signaling.	NA	Belongs to the FAM83 family.	NA	PE1	20
+NX_Q9BQP7	Mitochondrial genome maintenance exonuclease 1	344	39421	7.58	0	Mitochondrion	Mitochondrial DNA depletion syndrome 11	Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.	NA	Belongs to the MGME1 family.	NA	PE1	20
+NX_Q9BQP9	BPI fold-containing family A member 3	254	28436	6.17	0	Secreted	NA	NA	NA	Belongs to the BPI/LBP/Plunc superfamily. Plunc family.	NA	PE1	20
+NX_Q9BQQ3	Golgi reassembly-stacking protein 1	440	46482	4.42	0	Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment membrane;cis-Golgi network membrane	NA	Plays an important role in assembly and membrane stacking of the Golgi cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (PubMed:26363069). Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936).	Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimers into higher-order oligomers, leading to cisternal unstacking.;Myristoylated.;Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis.	Belongs to the GORASP family.	Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport	PE1	3
+NX_Q9BQQ7	Receptor-transporting protein 3	232	27031	8.97	1	Membrane;Mitochondrion	NA	Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43.	NA	Belongs to the TMEM7 family.	Olfactory Signaling Pathway	PE1	3
+NX_Q9BQR3	Serine protease 27	290	31940	8.47	0	Cytoplasmic vesicle;Secreted	NA	NA	N-glycosylated.	Belongs to the peptidase S1 family.	NA	PE1	16
+NX_Q9BQS2	Synaptotagmin-15	421	47375	7.12	1	Golgi apparatus;Cell membrane	NA	May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.	NA	Belongs to the synaptotagmin family.	NA	PE1	10
+NX_Q9BQS6	Heat shock protein beta-9	159	17486	9.16	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the small heat shock protein (HSP20) family.	NA	PE1	17
+NX_Q9BQS7	Hephaestin	1158	130449	5.61	1	Membrane;Nucleoplasm;Nucleus	NA	May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.	NA	Belongs to the multicopper oxidase family.	Mineral absorption;Iron uptake and transport;Metal ion SLC transporters;Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	PE1	X
+NX_Q9BQS8	FYVE and coiled-coil domain-containing protein 1	1478	166983	4.86	0	Cytoplasmic vesicle;Endosome;Autophagosome;Lysosome	Cataract 18	May mediate microtubule plus end-directed vesicle transport.	NA	NA	NA	PE1	3
+NX_Q9BQT8	Mitochondrial 2-oxodicarboxylate carrier	299	33303	9.53	6	Mitochondrion inner membrane	NA	Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Lysine catabolism	PE1	14
+NX_Q9BQT9	Calsyntenin-3	956	106098	5.24	1	Endoplasmic reticulum membrane;Cell membrane;Postsynapse;Golgi apparatus membrane;Dendrite	NA	May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.	Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-beta chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with gamma-secretase (By similarity).	NA	NA	PE1	12
+NX_Q9BQW3	Transcription factor COE4	602	64473	8.9	0	Nucleus	NA	Transcriptional factor which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.	NA	Belongs to the COE family.	NA	PE1	20
+NX_Q9BQY4	Rhox homeobox family member 2	288	31692	4.53	0	Nucleus	NA	Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.	NA	Belongs to the paired-like homeobox family. PEPP subfamily.	NA	PE1	X
+NX_Q9BQY6	WAP four-disulfide core domain protein 6	131	14626	8.64	0	Secreted	NA	NA	NA	NA	NA	PE2	20
+NX_Q9BQY9	Dysbindin domain-containing protein 2	259	27671	4.45	0	Nucleoplasm;Cytoplasm;Cytosol	NA	May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).	NA	Belongs to the dysbindin family.	NA	PE1	20
+NX_Q9BR01	Sulfotransferase 4A1	284	33085	5.42	0	Cytoplasm	NA	Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.	NA	Belongs to the sulfotransferase 1 family.	Cytosolic sulfonation of small molecules	PE1	22
+NX_Q9BR09	Neuralized-like protein 2	285	31690	7.76	0	Cytoplasm;Cytoplasmic vesicle	NA	Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).	NA	NA	Protein modification; protein ubiquitination.;Neddylation	PE2	20
+NX_Q9BR10	Spermatogenesis-associated protein 25	227	23834	8.59	1	Membrane;Golgi apparatus	NA	May play a role in spermatogenesis.	NA	Belongs to the SPATA25 family.	NA	PE1	20
+NX_Q9BR11	Zinc finger SWIM domain-containing protein 1	485	55071	7.05	0	Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	20
+NX_Q9BR26	Osteoclast stimulatory transmembrane protein	566	61579	8.88	6	Membrane	NA	Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).	NA	NA	NA	PE2	20
+NX_Q9BR39	Junctophilin-2	696	74222	8.82	1	Sarcoplasmic reticulum membrane;Endoplasmic reticulum membrane;Nucleus;Cell membrane	Cardiomyopathy, familial hypertrophic 17	Junctophilin-2 N-terminal fragment: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins.;Junctophilin-2: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity).	Phosphorylation on Ser-165, probably by PKC, affects RYR1-mediated calcium ion release, interaction with TRPC3, and skeletal muscle myotubule development.;Proteolytically cleaved by calpain in response to cardiac stress. The major cleavage site takes place at the C-terminus and leads to the release of the Junctophilin-2 N-terminal fragment chain (JP2NT).	Belongs to the junctophilin family.	NA	PE1	20
+NX_Q9BR46	Putative uncharacterized protein C20orf78	151	17183	8.93	0	NA	NA	NA	NA	NA	NA	PE4	20
+NX_Q9BR61	Acyl-CoA-binding domain-containing protein 6	282	31151	5	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.	NA	NA	Mitochondrial Fatty Acid Beta-Oxidation	PE1	1
+NX_Q9BR76	Coronin-1B	489	54235	5.6	0	Cytosol;Stress fiber;Cell membrane;Cytoskeleton	NA	Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).	Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location.	Belongs to the WD repeat coronin family.	NA	PE1	11
+NX_Q9BR77	Coiled-coil domain-containing protein 77	488	57486	8.91	0	Nucleus membrane	NA	NA	NA	NA	NA	PE1	12
+NX_Q9BR84	Zinc finger protein 559	538	62318	8.9	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9BRA0	N-alpha-acetyltransferase 38, NatC auxiliary subunit	125	13514	5.37	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.	NA	Belongs to the snRNP Sm proteins family.	Retrograde transport at the Trans-Golgi-Network	PE1	17
+NX_Q9BRA2	Thioredoxin domain-containing protein 17	123	13941	5.4	0	Cytoplasm	NA	Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.	The oxidized protein is reduced by TRXR1.	Belongs to the thioredoxin family.	NA	PE1	17
+NX_Q9BRB3	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q	760	84082	8.37	5	Membrane;Golgi apparatus;Nucleoplasm;Cytoplasmic vesicle	NA	Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.	NA	Belongs to the PIGQ family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	16
+NX_Q9BRC7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	762	87585	5.08	0	Cytoplasm;Cell membrane;Nucleus membrane;Membrane;Endoplasmic reticulum;Cytosol;Nucleus	NA	Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Phosphatidylinositol signaling system;Synthesis of IP3 and IP4 in the cytosol	PE1	2
+NX_Q9BRD0	BUD13 homolog	619	70521	9.86	0	Nucleoplasm;Nucleus	NA	Involved in pre-mRNA splicing as component of the activated spliceosome.	NA	Belongs to the CWC26 family.	NA	PE1	11
+NX_Q9BRF8	Serine/threonine-protein phosphatase CPPED1	314	35548	5.79	0	Cytoplasm;Cytosol;Cell membrane	NA	Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.	NA	Belongs to the metallophosphoesterase superfamily. CPPED1 family.	Neutrophil degranulation	PE1	16
+NX_Q9BRG1	Vacuolar protein-sorting-associated protein 25	176	20748	5.97	0	Nucleoplasm;Cytoplasm;Centrosome;Endosome membrane	NA	Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.	NA	Belongs to the VPS25 family.	Endocytosis;Endosomal Sorting Complex Required For Transport (ESCRT)	PE1	17
+NX_Q9BRG2	SH2 domain-containing protein 3A	576	63093	7.03	0	Nucleoplasm;Cytoskeleton	NA	May play a role in JNK activation.	Phosphorylated on tyrosine.	NA	NA	PE1	19
+NX_Q9BRH9	Zinc finger protein 251	671	75763	9.36	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_Q9BRI3	Zinc transporter 2	323	35178	5.7	5	Vacuole membrane;Cytoplasmic vesicle;Lysosome membrane	Zinc deficiency, transient neonatal	NA	NA	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.	Zinc efflux and compartmentalization by the SLC30 family	PE1	1
+NX_Q9BRJ2	39S ribosomal protein L45, mitochondrial	306	35351	9.14	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL45 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	17
+NX_Q9BRJ6	Uncharacterized protein C7orf50	194	22083	9.65	0	Nucleoplasm;Nucleus;Nucleolus	NA	NA	NA	NA	NA	PE1	7
+NX_Q9BRJ7	Tudor-interacting repair regulator protein	211	23338	9.07	0	Cytosol;Nucleus;Cell membrane	NA	Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).	NA	Belongs to the Nudix hydrolase family. TIRR subfamily.	NA	PE1	16
+NX_Q9BRJ9	Mesoderm posterior protein 1	268	28501	9.26	0	Nucleoplasm;Nucleolus;Nucleus	NA	Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).	NA	NA	NA	PE2	15
+NX_Q9BRK0	Receptor expression-enhancing protein 2	252	28261	9.54	2	Membrane	Spastic paraplegia 72	Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity).	NA	Belongs to the DP1 family.	Olfactory Signaling Pathway	PE1	5
+NX_Q9BRK3	Matrix remodeling-associated protein 8	442	49132	6.75	1	Cytoplasm;Cell membrane;Nucleolus;Tight junction;Cilium membrane;Nucleus	NA	(Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses.;Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity).	NA	NA	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	1
+NX_Q9BRK4	Leucine zipper putative tumor suppressor 2	669	72759	6.13	0	Cytoplasm;Cytosol;Centrosome;Cell membrane	NA	Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.	NA	Belongs to the LZTS2 family.	NA	PE1	10
+NX_Q9BRK5	45 kDa calcium-binding protein	362	41807	4.76	0	Golgi apparatus lumen;Golgi apparatus;Cytoplasm;Cell membrane;Bleb	NA	May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.;May be involved in the exocytosis of zymogens by pancreatic acini.	NA	Belongs to the CREC family.	NA	PE1	1
+NX_Q9BRL6	Serine/arginine-rich splicing factor 8	282	32288	11.72	0	Nucleus	NA	Involved in pre-mRNA alternative splicing.	NA	Belongs to the splicing factor SR family.	Spliceosome;Herpes simplex infection	PE1	11
+NX_Q9BRL7	Vesicle-trafficking protein SEC22c	303	34269	5.91	4	Golgi apparatus;Nucleoplasm;Endoplasmic reticulum membrane	NA	May be involved in vesicle transport between the ER and the Golgi complex.	NA	Belongs to the synaptobrevin family.	COPII-mediated vesicle transport	PE1	3
+NX_Q9BRN9	TM2 domain-containing protein 3	247	27118	8.43	2	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the TM2 family.	NA	PE1	15
+NX_Q9BRP0	Transcription factor Ovo-like 2	275	30438	9.02	0	Nucleoplasm;Cytosol;Nucleus	Corneal dystrophy, posterior polymorphous, 1	Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410). Important for the correct development of primordial germ cells in embryos (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	20
+NX_Q9BRP1	Programmed cell death protein 2-like	358	39417	4.71	0	Mitochondrion	NA	Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.	NA	NA	NA	PE1	19
+NX_Q9BRP4	Proteasomal ATPase-associated factor 1	392	42190	5.92	0	Nucleoplasm;Cytosol	NA	Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.	NA	Belongs to the WD repeat PAAF1/RPN14 family.	NA	PE1	11
+NX_Q9BRP7	Ferredoxin-fold anticodon-binding domain-containing protein 1	624	70416	6.29	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	11
+NX_Q9BRP8	Partner of Y14 and mago	204	22656	9.45	0	Cytoplasm;Cell junction;Nucleolus;Nucleoplasm;Cytosol	NA	Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.	NA	Belongs to the pym family.	RNA transport;mRNA surveillance pathway	PE1	12
+NX_Q9BRP9	Putative uncharacterized protein MGC13053	147	15625	9.02	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q9BRQ0	Pygopus homolog 2	406	41244	6.89	0	Nucleoplasm;Nucleus	NA	Involved in signal transduction through the Wnt pathway.	NA	NA	Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex	PE1	1
+NX_Q9BRQ3	Uridine diphosphate glucose pyrophosphatase NUDT22	303	32580	4.99	0	Nucleoplasm	NA	Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose.	NA	Belongs to the Nudix hydrolase family.	NA	PE1	11
+NX_Q9BRQ4	Cilia- and flagella-associated protein 300	267	30859	6.39	0	Cytoplasm;Centrosome;Cilium axoneme	Ciliary dyskinesia, primary, 38	Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.	NA	Belongs to the CFAP300 family.	NA	PE1	11
+NX_Q9BRQ5	Protein orai-3	295	31499	7.21	4	Membrane;Nucleoplasm;Cytosol	NA	Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.	NA	Belongs to the Orai family.	NA	PE1	16
+NX_Q9BRQ6	MICOS complex subunit MIC25	235	26458	9.01	0	Cytoplasm;Mitochondrion inner membrane;Mitochondrion;Nucleus	NA	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	NA	Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.	Cristae formation	PE1	3
+NX_Q9BRQ8	Apoptosis-inducing factor 2	373	40527	9.16	1	Mitochondrion outer membrane;Cytoplasm;Cell membrane;Membrane;Cytoplasmic vesicle;Cytosol	NA	Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.	NA	Belongs to the FAD-dependent oxidoreductase family.	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	PE1	10
+NX_Q9BRR0	Zinc finger protein with KRAB and SCAN domains 3	538	60641	5.98	0	Cytoplasm;Nucleus	NA	Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	6
+NX_Q9BRR3	Transmembrane protein 246	403	46588	7.27	3	Membrane;Mitochondrion	NA	NA	NA	Belongs to the TMEM246 family.	NA	PE1	9
+NX_Q9BRR6	ADP-dependent glucokinase	497	54089	5.77	0	Cytoplasm;Centrosome;Secreted;Nucleus	NA	Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).	NA	Belongs to the ADP-dependent glucokinase family.	Carbohydrate degradation; glycolysis.;Glycolysis / Gluconeogenesis;Metabolic pathways;Glycolysis	PE1	15
+NX_Q9BRR8	G patch domain-containing protein 1	931	103345	6.59	0	Nucleoplasm;Cell junction;Cell membrane	NA	NA	NA	Belongs to the GPATCH1 family.	NA	PE1	19
+NX_Q9BRR9	Rho GTPase-activating protein 9	750	83260	8.65	0	NA	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.	NA	NA	Rho GTPase cycle;Neutrophil degranulation	PE1	12
+NX_Q9BRS2	Serine/threonine-protein kinase RIO1	568	65583	5.84	0	Cytosol;Nucleus speckle;Nucleolus	NA	Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503).	NA	Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	Ribosome biogenesis in eukaryotes;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	6
+NX_Q9BRS8	La-related protein 6	491	54737	8.4	0	Cytoplasm;Nucleus;Cytoskeleton	NA	Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.	NA	NA	NA	PE1	15
+NX_Q9BRT2	Ubiquinol-cytochrome-c reductase complex assembly factor 2	126	14875	6.84	0	Mitochondrion;Mitochondrion matrix;Mitochondrion intermembrane space;Mitochondrion nucleoid;Mitochondrion inner membrane;Nucleus	Mitochondrial complex III deficiency, nuclear 7	Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability.	NA	NA	NA	PE1	6
+NX_Q9BRT3	Migration and invasion enhancer 1	115	12403	4.4	0	Cytosol;Cell membrane	NA	Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.	Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.	Belongs to the SelWTH family.	NA	PE1	17
+NX_Q9BRT6	Protein LLP homolog	129	15225	10.38	0	Nucleolus;Chromosome	NA	In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.	NA	Belongs to the learning-associated protein family.	NA	PE1	12
+NX_Q9BRT8	COBW domain-containing protein 1	395	44068	4.76	0	NA	NA	NA	NA	Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.	NA	PE1	9
+NX_Q9BRT9	DNA replication complex GINS protein SLD5	223	26047	4.94	0	Cytoplasm;Nucleoplasm;Centrosome;Nucleus	NA	The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.	NA	Belongs to the GINS4/SLD5 family.	Unwinding of DNA	PE1	8
+NX_Q9BRU2	Transcription elongation factor A protein-like 7	100	12324	8.46	0	Nucleoplasm;Nucleus	NA	Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.	NA	Belongs to the TFS-II family. TFA subfamily.	NA	PE1	X
+NX_Q9BRU9	rRNA-processing protein UTP23 homolog	249	28402	10.08	0	Nucleolus	NA	Involved in rRNA-processing and ribosome biogenesis.	NA	Belongs to the UTP23/FCF1 family. UTP23 subfamily.	NA	PE1	8
+NX_Q9BRV3	Sugar transporter SWEET1	221	25030	8.8	7	Cell membrane;Golgi apparatus membrane	NA	Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.	NA	Belongs to the SWEET sugar transporter family.	Cellular hexose transport	PE1	1
+NX_Q9BRV8	Suppressor of IKBKE 1	207	23721	5.09	0	Cytoplasm;Focal adhesion;Cytoplasmic vesicle	NA	Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.	NA	Belongs to the SIKE family.	RIG-I-like receptor signaling pathway;TRAF6 mediated IRF7 activation;TRAF3-dependent IRF activation pathway	PE1	1
+NX_Q9BRX2	Protein pelota homolog	385	43359	5.93	0	Cytoplasm;Nucleolus;Nucleus	NA	Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential).	NA	Belongs to the eukaryotic release factor 1 family. Pelota subfamily.	mRNA surveillance pathway	PE1	5
+NX_Q9BRX5	DNA replication complex GINS protein PSF3	216	24535	5.21	0	Nucleoplasm;Nucleus	NA	The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.	NA	Belongs to the GINS3/PSF3 family.	Unwinding of DNA	PE1	16
+NX_Q9BRX8	Peroxiredoxin-like 2A	229	25764	8.92	0	Cytoplasm;Secreted	NA	Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).	NA	Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.	NA	PE1	10
+NX_Q9BRX9	WD repeat domain-containing protein 83	315	34343	5.36	0	Cytoplasm;Nucleoplasm;Centrosome;Cytoplasmic vesicle;Nucleus	NA	Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.	NA	Belongs to the WD repeat MORG1 family.	MAP2K and MAPK activation	PE1	19
+NX_Q9BRY0	Zinc transporter ZIP3	314	33601	6.39	8	Membrane;Cytoplasmic vesicle	NA	Acts as a zinc-influx transporter.	NA	Belongs to the ZIP transporter (TC 2.A.5) family.	Zinc influx into cells by the SLC39 gene family	PE1	19
+NX_Q9BRZ2	E3 ubiquitin-protein ligase TRIM56	755	81488	8.02	0	Cytoplasm;Nucleoplasm;Cytosol	NA	E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).	Autoubiquitinated.	Belongs to the TRIM/RBCC family.	Regulation of innate immune responses to cytosolic DNA	PE1	7
+NX_Q9BS16	Centromere protein K	269	31655	4.83	0	Kinetochore;Centromere;Nucleus	NA	Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore.	NA	Belongs to the CENP-K/MCM22 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	5
+NX_Q9BS18	Anaphase-promoting complex subunit 13	74	8521	4.04	0	Cytosol;Mitochondrion;Nucleus	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	NA	Belongs to the APC13 family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	3
+NX_Q9BS26	Endoplasmic reticulum resident protein 44	406	46971	5.09	0	Endoplasmic reticulum lumen	NA	Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.	NA	NA	Neutrophil degranulation	PE1	9
+NX_Q9BS31	Zinc finger protein 649	505	57683	9.03	0	Nucleus	NA	Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9BS34	Zinc finger protein 670	389	44603	8.8	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q9BS40	Latexin	222	25750	5.54	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.	NA	Belongs to the protease inhibitor I47 (latexin) family.	NA	PE1	3
+NX_Q9BS86	Zona pellucida-binding protein 1	351	40142	9.42	0	Acrosome membrane;Secreted	NA	Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).	N-glycosylated.	Belongs to the zona pellucida-binding protein Sp38 family.	NA	PE1	7
+NX_Q9BS91	Probable UDP-sugar transporter protein SLC35A5	424	48500	8.55	10	Membrane;Golgi apparatus	NA	NA	NA	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.	NA	PE1	3
+NX_Q9BS92	Protein NipSnap homolog 3B	247	28313	9.32	0	NA	NA	NA	NA	Belongs to the NipSnap family.	NA	PE1	9
+NX_Q9BSA4	Protein tweety homolog 2	534	58772	5.48	5	Cell membrane	NA	Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation.	NA	Belongs to the tweety family.	Stimuli-sensing channels	PE1	17
+NX_Q9BSA9	Endosomal/lysosomal potassium channel TMEM175	504	55615	7.61	12	Nucleoplasm;Lysosome membrane;Nucleus membrane;Endosome membrane	Parkinson disease	Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.	NA	Belongs to the TMEM175 family.	NA	PE1	4
+NX_Q9BSB4	Autophagy-related protein 101	218	25003	5.81	0	Preautophagosomal structure;Cytoplasm	NA	Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.	NA	Belongs to the ATG101 family.	Macroautophagy	PE1	12
+NX_Q9BSC4	Nucleolar protein 10	688	80302	8.64	0	Nucleolus	NA	NA	NA	Belongs to the WD repeat NOL10/ENP2 family.	NA	PE1	2
+NX_Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	238	26709	9.69	0	Nucleus;Chromosome	NA	Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.	NA	NA	G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	12
+NX_Q9BSD7	Cancer-related nucleoside-triphosphatase	190	20713	9.61	0	Cytosol	NA	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.	NA	Belongs to the THEP1 NTPase family.	Purine metabolism;Thiamine metabolism;Metabolic pathways	PE1	1
+NX_Q9BSE2	Transmembrane protein 79	394	43520	4.87	5	Membrane;trans-Golgi network;Nucleolus;Lysosome	NA	Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity).	NA	NA	NA	PE1	1
+NX_Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	406	45147	4.93	1	Membrane;Nucleolus	NA	Could be involved in the unfolded protein response (UPR) pathway.	NA	NA	NA	PE1	7
+NX_Q9BSE5	Agmatinase, mitochondrial	352	37660	7.54	0	Mitochondrion	NA	NA	NA	Belongs to the arginase family. Agmatinase subfamily.	Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.;Arginine and proline metabolism;Metabolic pathways;Agmatine biosynthesis	PE1	1
+NX_Q9BSF0	Small membrane A-kinase anchor protein	95	10970	4.84	0	Cell membrane	NA	Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane.	May be palmitoylated at Cys-3.	Belongs to the small membrane AKAP family.	NA	PE1	2
+NX_Q9BSF4	Mitochondrial import inner membrane translocase subunit Tim29	260	29233	8.29	1	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40.	NA	NA	NA	PE1	19
+NX_Q9BSF8	BTB/POZ domain-containing protein 10	475	53779	7.65	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	NA	Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.	NA	NA	NA	PE1	11
+NX_Q9BSG0	Protease-associated domain-containing protein 1	188	21042	5.23	0	Secreted	NA	NA	N-glycosylated; required for efficient secretion.	NA	NA	PE1	2
+NX_Q9BSG1	Zinc finger protein 2	425	48707	8.86	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	2
+NX_Q9BSG5	Retbindin	229	24615	8.59	0	Endoplasmic reticulum;Interphotoreceptor matrix;Cell membrane	NA	Riboflavin-binding protein which might have a role in retinal flavin transport.	Not N-glycosylated.	Belongs to the folate receptor family.	NA	PE1	19
+NX_Q9BSH3	Nicolin-1	213	24202	6.59	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	Carboxyterminal post-translational modifications of tubulin	PE1	3
+NX_Q9BSH4	Translational activator of cytochrome c oxidase 1	297	32477	8.37	0	Mitochondrion	Leigh syndrome	Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.	NA	Belongs to the TACO1 family.	Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	17
+NX_Q9BSH5	Haloacid dehalogenase-like hydrolase domain-containing protein 3	251	28000	6.21	0	Cytoplasmic vesicle;Nucleolus	NA	NA	NA	Belongs to the HAD-like hydrolase superfamily.	NA	PE1	9
+NX_Q9BSI4	TERF1-interacting nuclear factor 2	451	50023	8.2	0	Nucleoplasm;Nucleus matrix;Telomere;Nucleus	Dyskeratosis congenita, autosomal dominant, 3;Dyskeratosis congenita, autosomal dominant, 5	Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly.;May have additional role in tethering telomeres to the nuclear matrix.	NA	NA	Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine	PE1	14
+NX_Q9BSJ1	Tripartite motif-containing protein 51	452	52285	5.72	0	Cytoplasmic vesicle;Nucleolus	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE2	11
+NX_Q9BSJ2	Gamma-tubulin complex component 2	902	102534	6.38	0	Nucleoplasm;Centrosome	NA	Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.	NA	Belongs to the TUBGCP family.	Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes	PE1	10
+NX_Q9BSJ5	Uncharacterized protein C17orf80	609	67315	9.3	1	Membrane;Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	NA	NA	PE1	17
+NX_Q9BSJ6	Protein PIMREG	248	27480	10.22	0	Nucleoplasm;Nucleolus;Nucleus	NA	During mitosis, may play a role in the control of metaphase-to-anaphase transition.	Ubiquitinated by the anaphase-promoting complex/cyclosome (APC/C) complex in the presence of FZR1, leading to its degradation by the proteasome during mitotic exit. However, degradation is not essential for normal mitotic progression within a single cell cycle.	NA	NA	PE1	17
+NX_Q9BSJ8	Extended synaptotagmin-1	1104	122856	5.57	2	Endoplasmic reticulum;Endoplasmic reticulum membrane;Cell membrane	NA	Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.	Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro); this promotes interaction with SLC2A4.	Belongs to the extended synaptotagmin family.	Glycosphingolipid metabolism	PE1	12
+NX_Q9BSK0	MARVEL domain-containing protein 1	173	18914	9.69	4	Cytoskeleton;Nucleus;Cell membrane	NA	Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.	NA	NA	NA	PE1	10
+NX_Q9BSK1	Zinc finger protein 577	485	54939	9.39	0	Nucleoplasm;Nucleus;Nucleolus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9BSK2	Solute carrier family 25 member 33	321	35375	9.65	6	Mitochondrion inner membrane	NA	Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). Also transports guanine but not adenine (deoxy)nucleotides (PubMed:25320081). Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (PubMed:14715278).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	1
+NX_Q9BSK4	Protein fem-1 homolog A	669	73639	5.71	0	Golgi apparatus;Nucleoplasm;Cytoplasm;Cytosol	NA	Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.	NA	Belongs to the fem-1 family.	Protein modification; protein ubiquitination.;Neddylation	PE1	19
+NX_Q9BSL1	Ubiquitin-associated domain-containing protein 1	405	45338	4.82	0	Golgi apparatus;Cytoplasm;Cytosol;Cell membrane	NA	Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	9
+NX_Q9BSM1	Polycomb group RING finger protein 1	259	30346	9.14	0	Nucleoplasm;Nucleus	NA	Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479).	NA	NA	NA	PE1	2
+NX_Q9BSN7	Transmembrane protein 204	226	24540	8.1	4	Adherens junction;Cell membrane	NA	Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.	NA	NA	NA	PE2	16
+NX_Q9BSQ5	Cerebral cavernous malformations 2 protein	444	48837	5.32	0	Cytoplasm;Mitochondrion	Cerebral cavernous malformations 2	Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).	NA	Belongs to the CCM2 family.	NA	PE1	7
+NX_Q9BSR8	Protein YIPF4	244	27083	4.5	5	Golgi apparatus;Cell membrane;cis-Golgi network membrane;Endoplasmic reticulum;Cytoplasmic vesicle	NA	Involved in the maintenance of the Golgi structure.	NA	Belongs to the YIP1 family.	NA	PE1	2
+NX_Q9BST9	Rhotekin	563	62667	7.18	0	Nucleoplasm;Mitochondrion	NA	Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.	NA	NA	RHO GTPases Activate Rhotekin and Rhophilins	PE1	2
+NX_Q9BSU1	UPF0183 protein C16orf70	422	47524	7.64	0	Cytosol;Nucleus speckle;Nucleolus	NA	NA	NA	Belongs to the UPF0183 family.	NA	PE1	16
+NX_Q9BSU3	N-alpha-acetyltransferase 11	229	25979	5.05	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.	NA	Belongs to the acetyltransferase family. ARD1 subfamily.	NA	PE1	4
+NX_Q9BSV6	tRNA-splicing endonuclease subunit Sen34	310	33652	8.53	0	Nucleoplasm;Nucleus;Nucleolus	Pontocerebellar hypoplasia 2C	Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.	NA	Belongs to the tRNA-intron endonuclease family.	tRNA processing in the nucleus	PE1	19
+NX_Q9BSW2	EF-hand calcium-binding domain-containing protein 4B	395	45592	4.95	0	Cytoplasm	NA	Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.	NA	Belongs to the EFCAB4 family.	Neutrophil degranulation	PE1	12
+NX_Q9BSW7	Synaptotagmin-17	474	53849	7.23	0	Membrane;Nucleoplasm;Cytosol	NA	Plays a role in dendrite formation by melanocytes (PubMed:23999003).	NA	Belongs to the synaptotagmin family.	NA	PE1	16
+NX_Q9BSY4	Coiled-coil-helix-coiled-coil-helix domain-containing protein 5	110	12395	6.28	0	Mitochondrion intermembrane space;Mitochondrion	NA	NA	NA	NA	Mitochondrial protein import	PE1	2
+NX_Q9BSY9	Deubiquitinase DESI2	194	21444	4.86	0	Cytoplasm;Cytoplasmic vesicle	NA	Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520).	NA	Belongs to the DeSI family.	NA	PE1	1
+NX_Q9BT04	Protein fuzzy homolog	418	45679	5.9	0	Cytoplasm;Cytosol;Cilium basal body;Cytoskeleton	NA	Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity).	NA	Belongs to the fuzzy family.	Hedgehog 'off' state	PE1	19
+NX_Q9BT09	Protein canopy homolog 3	278	30748	5.36	0	Endoplasmic reticulum	Epileptic encephalopathy, early infantile, 60	Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity).	NA	Belongs to the canopy family.	Trafficking and processing of endosomal TLR	PE1	6
+NX_Q9BT17	Mitochondrial ribosome-associated GTPase 1	334	37237	9.54	0	Mitochondrion inner membrane;Mitochondrion	NA	Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.	NA	Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.	NA	PE1	10
+NX_Q9BT22	Chitobiosyldiphosphodolichol beta-mannosyltransferase	464	52518	6.8	1	Endoplasmic reticulum membrane	Congenital disorder of glycosylation 1K	Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.	NA	Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG1 causes ALG1-CDG (CDG-1k)	PE1	16
+NX_Q9BT23	LIM domain-containing protein 2	127	14070	9.23	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Acts as an activator of the protein-kinase ILK, thereby regulating cell motility (PubMed:24590809).	NA	NA	NA	PE1	17
+NX_Q9BT25	HAUS augmin-like complex subunit 8	410	44857	6.6	0	Cytoplasm;Spindle pole;Spindle;Centrosome	NA	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.	NA	Belongs to the HAUS8 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	19
+NX_Q9BT30	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial	221	24516	6.61	0	Mitochondrion matrix;Mitochondrion	NA	May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).	NA	Belongs to the alkB family.	NA	PE1	19
+NX_Q9BT40	Inositol polyphosphate 5-phosphatase K	448	51090	6.07	0	Endoplasmic reticulum;Cytoplasm	Muscular dystrophy, congenital, with cataracts and intellectual disability	Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PubMed:10753883, PubMed:16824732). Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity).	NA	Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Insulin signaling pathway;Synthesis of PIPs at the plasma membrane	PE1	17
+NX_Q9BT43	DNA-directed RNA polymerase III subunit RPC7-like	218	25334	4.49	0	Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.	NA	Belongs to the eukaryotic RPC7 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	1
+NX_Q9BT49	THAP domain-containing protein 7	309	34414	9.54	0	Nucleoplasm;Chromosome;Nucleus;Cytoplasmic vesicle	NA	Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.	NA	NA	NA	PE1	22
+NX_Q9BT56	Spexin	116	13302	9.73	0	Secreted;Secretory vesicle;Extracellular space	NA	Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231).;Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity).;Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity).	NA	NA	NA	PE1	12
+NX_Q9BT67	NEDD4 family-interacting protein 1	221	24899	4.55	3	Endosome membrane;Synaptosome;Secreted;Golgi apparatus membrane;Dendrite	NA	Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion (PubMed:26319551). Restricts the production of proinflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC (By similarity). Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells (By similarity). Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS (PubMed:23087404). Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation (PubMed:26363003). In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity (PubMed:19706893). Important for normal development of dendrites and dendritic spines in cortex (By similarity). Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046). Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH (By similarity). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (PubMed:20534535). Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity (PubMed:25801959).	Undergoes transient tyrosine phosphorylation following EGF stimulation, most probably by catalyzed by SRC. Phosphorylation SRC is enhanced in the presence of NDFIP2 which may act as a scaffold to recruit SRC to NDFIP1.;Ubiquitinated by NEDD4 and ITCH; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its degradation.	NA	NA	PE1	5
+NX_Q9BT73	Proteasome assembly chaperone 3	122	13104	7.72	0	Cytoplasm	NA	Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.	NA	Belongs to the PSMG3 family.	NA	PE1	7
+NX_Q9BT76	Uroplakin-3b	320	33882	6.33	1	Cell membrane	NA	Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).	NA	Belongs to the uroplakin-3 family.	NA	PE1	7
+NX_Q9BT78	COP9 signalosome complex subunit 4	406	46269	5.57	0	Cytoplasm;Nucleus speckle;Synaptic vesicle;Nucleus	NA	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.	NA	Belongs to the CSN4 family.	Formation of TC-NER Pre-Incision Complex;DNA Damage Recognition in GG-NER;Cargo recognition for clathrin-mediated endocytosis;Neddylation	PE1	4
+NX_Q9BT81	Transcription factor SOX-7	388	42197	6.2	0	Golgi apparatus;Cytoplasm;Nucleus speckle;Nucleus	NA	Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.	NA	NA	Deactivation of the beta-catenin transactivating complex	PE1	8
+NX_Q9BT88	Synaptotagmin-11	431	48297	9.15	1	Lysosome membrane;trans-Golgi network membrane;Perikaryon;Cytoplasmic vesicle membrane;Recycling endosome membrane;Phagosome;Postsynaptic density;Clathrin-coated vesicle membrane;Axon;Dendrite	NA	Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822).	Ubiquitinated, at least by PRKN, and targeted to the proteasome complex for degradation (PubMed:12925569, PubMed:27278822). Ubiquitination is inhibited by ATP13A2 (PubMed:27278822).	Belongs to the synaptotagmin family.	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	1
+NX_Q9BT92	Trichoplein keratin filament-binding protein	498	61072	6.2	0	Cytoplasm;Desmosome;Mitochondrion;Cell membrane;Centrosome;Cytosol;Cytoskeleton	NA	Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598).	Ubiquitinated. Ubiquitination by the BCR(KCTD17) E3 ubiquitin ligase complex results in proteasomal degradation, and induces ciliogenesis.	Belongs to the TCHP family.	NA	PE1	12
+NX_Q9BTA0	Protein FAM167B	163	18414	5.28	0	Cytoskeleton	NA	NA	NA	Belongs to the FAM167 (SEC) family.	NA	PE1	1
+NX_Q9BTA9	WW domain-containing adapter protein with coiled-coil	647	70724	9.49	0	Nucleoplasm;Nucleus speckle;Nucleus	DeSanto-Shinawi syndrome	Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877).	Phosphorylated on tyrosine residues.	NA	E3 ubiquitin ligases ubiquitinate target proteins	PE1	10
+NX_Q9BTC0	Death-inducer obliterator 1	2240	243873	8.09	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Spindle;Nucleus	NA	Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development.;Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.	NA	NA	Meiotic synapsis	PE1	20
+NX_Q9BTC8	Metastasis-associated protein MTA3	594	67504	8.8	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.	NA	NA	RNA Polymerase I Transcription Initiation;HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of PTEN gene transcription	PE1	2
+NX_Q9BTD1	Putative uncharacterized protein SHANK2-AS3	123	13317	9.49	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q9BTD3	Transmembrane protein 121	319	35814	9.39	7	Membrane;Cytosol	NA	May play a role in MAPK signaling.	NA	Belongs to the TMEM121 family.	NA	PE2	14
+NX_Q9BTD8	RNA-binding protein 42	480	50414	9.65	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA.	NA	Belongs to the RRM RBM42 family.	NA	PE1	19
+NX_Q9BTE0	N-acetyltransferase 9	207	23361	4.67	0	Cytoplasm;Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the acetyltransferase family. GNAT subfamily.	NA	PE1	17
+NX_Q9BTE1	Dynactin subunit 5	182	20127	8.32	0	Nucleoplasm;Nucleus membrane;Kinetochore;Cytoskeleton	NA	NA	NA	Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.	Vasopressin-regulated water reabsorption;MHC class II antigen presentation;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	16
+NX_Q9BTE3	Mini-chromosome maintenance complex-binding protein	642	72980	5.56	0	Nucleoplasm;Cytosol;Cell junction;Nucleus	NA	Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.	NA	Belongs to the MCMBP family.	NA	PE1	10
+NX_Q9BTE6	Alanyl-tRNA editing protein Aarsd1	412	45480	6	0	Cytoplasm;Cytosol;Nucleus membrane	NA	Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).	NA	Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.	NA	PE1	17
+NX_Q9BTE7	DCN1-like protein 5	237	27508	5.44	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	Neddylation	PE1	11
+NX_Q9BTF0	THUMP domain-containing protein 2	503	56433	7.92	0	Nucleoplasm	NA	NA	NA	Belongs to the methyltransferase superfamily.	NA	PE1	2
+NX_Q9BTK2	Putative uncharacterized protein LOC642776	45	4916	11.19	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_Q9BTK6	PAXIP1-associated glutamate-rich protein 1	254	27716	4.4	0	Nucleus	NA	Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582).	NA	NA	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	16
+NX_Q9BTL3	RNA guanine-N7 methyltransferase activating subunit	118	14381	8.89	0	Nucleoplasm;Nucleus	NA	Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306).	NA	Belongs to the RAM family.	NA	PE1	15
+NX_Q9BTL4	Immediate early response gene 2 protein	223	24196	6.46	0	Nucleoplasm;Cytoplasm;Nucleus	NA	DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).	NA	Belongs to the IER family.	NA	PE1	19
+NX_Q9BTM1	Histone H2A.J	129	14019	10.9	0	Nucleus;Chromosome	NA	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity).;Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription (By similarity).;Monoubiquitination of Lys-120 (H2AXK119ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties (By similarity).	Belongs to the histone H2A family.	Systemic lupus erythematosus;Transcriptional regulation by small RNAs;RMTs methylate histone arginines;NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Escape;Oxidative Stress Induced Senescence;Meiotic synapsis;Packaging Of Telomere Ends;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;SIRT1 negatively regulates rRNA expression;DNA methylation;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;Meiotic recombination;Pre-NOTCH Transcription and Translation;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine;Activation of anterior HOX genes in hindbrain development during early embryogenesis;B-WICH complex positively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Estrogen-dependent gene expression;Transcriptional regulation of granulopoiesis	PE1	12
+NX_Q9BTM9	Ubiquitin-related modifier 1	101	11380	4.54	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle	NA	Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.	C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.	Belongs to the URM1 family.	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.;Sulfur relay system;tRNA modification in the nucleus and cytosol	PE1	9
+NX_Q9BTN0	Leucine-rich repeat and fibronectin type-III domain-containing protein 3	628	66260	6.88	1	Presynaptic cell membrane;Cell membrane;Postsynaptic cell membrane;Synapse;Axon;Dendrite	NA	Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity).	N-glycosylated.	Belongs to the LRFN family.	Synaptic adhesion-like molecules	PE1	19
+NX_Q9BTP6	Zinc finger BED domain-containing protein 2	218	25122	6.57	0	Cytosol;Mitochondrion;Nucleus	NA	NA	NA	NA	NA	PE1	3
+NX_Q9BTP7	Fanconi anemia core complex-associated protein 24	215	23897	9.28	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.	NA	NA	Fanconi anemia pathway;Fanconi Anemia Pathway	PE1	19
+NX_Q9BTT0	Acidic leucine-rich nuclear phosphoprotein 32 family member E	268	30692	3.77	0	Cytoplasm;Nucleus	NA	Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.	Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity).	Belongs to the ANP32 family.	NA	PE1	1
+NX_Q9BTT4	Mediator of RNA polymerase II transcription subunit 10	135	15688	5.82	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 10 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	5
+NX_Q9BTT6	Leucine-rich repeat-containing protein 1	524	59242	4.94	0	Membrane;Cytoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	6
+NX_Q9BTU6	Phosphatidylinositol 4-kinase type 2-alpha	479	54022	8.51	0	Mitochondrion;Presynaptic cell membrane;Cell membrane;Synaptosome;trans-Golgi network membrane;Perikaryon;Membrane;Endosome;Membrane raft;Cytoplasmic vesicle;Neuron projection;Dendrite	NA	Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).	Ubiquitinated by ITCH; this does not lead to proteasomal degradation.;Palmitoylated by ZDHHC3 and ZDHHC7 in the CCPCC motif. Palmitoylation is cholesterol-dependent, and required for TGN localization.	Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane	PE1	10
+NX_Q9BTV4	Transmembrane protein 43	400	44876	7.86	4	Endoplasmic reticulum;Golgi apparatus;Nucleus inner membrane	Arrhythmogenic right ventricular dysplasia, familial, 5;Emery-Dreifuss muscular dystrophy 7, autosomal dominant	May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity).	NA	Belongs to the TMEM43 family.	NA	PE1	3
+NX_Q9BTV5	Fibronectin type III and SPRY domain-containing protein 1	496	55820	6.54	0	Cytoplasm;Centrosome;Cleavage furrow;Nucleus	NA	May be involved in microtubule organization and stabilization.	NA	NA	NA	PE1	19
+NX_Q9BTV6	Diphthine methyltransferase	452	50575	6.11	0	Nucleus	NA	Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).	NA	Belongs to the DPH7 family.	Protein modification; peptidyl-diphthamide biosynthesis.;Synthesis of diphthamide-EEF2	PE1	9
+NX_Q9BTV7	CDK5 and ABL1 enzyme substrate 2	478	52235	9.84	0	Nucleoplasm;Cell junction;Nucleus	NA	Unknown. Probably involved in G1-S cell cycle transition.	NA	Belongs to the cyclin family.	Factors involved in megakaryocyte development and platelet production	PE1	20
+NX_Q9BTW9	Tubulin-specific chaperone D	1192	132600	5.8	0	Cytoplasm;Lateral cell membrane;Adherens junction;Tight junction;Centrosome	Encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum	Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374).	NA	Belongs to the TBCD family.	Post-chaperonin tubulin folding pathway	PE1	17
+NX_Q9BTX1	Nucleoporin NDC1	674	76305	9.22	6	Cytoskeleton;Cell membrane;Nucleus membrane;Nuclear pore complex	NA	Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.	NA	Belongs to the NDC1 family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	1
+NX_Q9BTX3	Transmembrane protein 208	173	19642	9.33	3	Endoplasmic reticulum membrane	NA	May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.	NA	Belongs to the TMEM208 family.	NA	PE1	16
+NX_Q9BTX7	Alpha-tocopherol transfer protein-like	342	38515	6.03	0	Golgi apparatus;Cytosol	NA	May act as a protein that binds a hydrophobic ligand.	NA	NA	NA	PE1	20
+NX_Q9BTY2	Plasma alpha-L-fucosidase	467	54067	5.84	0	Secreted	NA	Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	NA	Belongs to the glycosyl hydrolase 29 family.	Other glycan degradation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation	PE1	6
+NX_Q9BTY7	Protein HGH1 homolog	390	42129	4.73	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	Belongs to the HGH1 family.	NA	PE1	8
+NX_Q9BTZ2	Dehydrogenase/reductase SDR family member 4	278	29537	8.81	0	Peroxisome;Nucleus	NA	Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Retinol metabolism;Metabolic pathways;Peroxisome;RA biosynthesis pathway;Peroxisomal protein import	PE1	14
+NX_Q9BU02	Thiamine-triphosphatase	230	25566	4.75	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	Hydrolase highly specific for thiamine triphosphate (ThTP).	NA	Belongs to the ThTPase family.	Thiamine metabolism;Metabolic pathways;Vitamin B1 (thiamin) metabolism	PE1	14
+NX_Q9BU19	Zinc finger protein 692	519	56968	7.54	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q9BU20	Ciliogenesis and planar polarity effector 2	258	28498	7.06	0	Nucleoplasm;Cilium basal body	NA	Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).	NA	Belongs to the small GTPase superfamily. Rab family.	NA	PE1	1
+NX_Q9BU23	Lipase maturation factor 2	707	79698	10.1	11	Endoplasmic reticulum;Endoplasmic reticulum membrane;Centrosome	NA	Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).	NA	Belongs to the lipase maturation factor family.	Assembly of active LPL and LIPC lipase complexes	PE1	22
+NX_Q9BU40	Chordin-like protein 1	456	52026	8.71	0	Secreted	Megalocornea 1, X-linked	Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.	NA	NA	Signaling by BMP;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	X
+NX_Q9BU61	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3	184	20350	8.48	0	Mitochondrion inner membrane;Nucleus	Mitochondrial complex I deficiency, nuclear type 18	Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).	NA	NA	Complex I biogenesis	PE1	3
+NX_Q9BU64	Centromere protein O	300	33786	7.63	0	Kinetochore;Nucleoplasm;Centromere;Nucleus	NA	Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex.	NA	Belongs to the CENP-O/MCM21 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	2
+NX_Q9BU68	Proline-rich protein 15-like protein	103	11705	9.49	0	Cytosol	NA	NA	NA	Belongs to the PRR15 family.	NA	PE1	17
+NX_Q9BU70	tRNA (adenine(37)-N6)-methyltransferase	441	48587	6.74	0	Nucleoplasm	NA	S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity).	NA	NA	NA	PE1	9
+NX_Q9BU76	Multiple myeloma tumor-associated protein 2	263	29412	10.03	0	Cytosol;Nucleus speckle;Cell membrane	NA	NA	NA	NA	Neutrophil degranulation	PE1	1
+NX_Q9BU79	Transmembrane protein 243	118	13391	8.4	3	Membrane	NA	NA	NA	Belongs to the TMEM243 family.	NA	PE1	7
+NX_Q9BU89	Deoxyhypusine hydroxylase	302	32904	4.74	0	Nucleoplasm;Cytosol;Nucleolus	NA	Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16533814, PubMed:16371467, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity).	NA	Belongs to the deoxyhypusine hydroxylase family.	Protein modification; eIF5A hypusination.;Hypusine synthesis from eIF5A-lysine	PE1	19
+NX_Q9BUA3	Spindlin interactor and repressor of chromatin-binding protein	381	41037	4.92	0	Nucleus speckle	NA	Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846).	NA	NA	NA	PE1	11
+NX_Q9BUA6	Myosin regulatory light chain 10	226	25308	5.56	0	Mitochondrion	NA	NA	NA	NA	Focal adhesion;Tight junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Smooth Muscle Contraction	PE1	7
+NX_Q9BUB4	tRNA-specific adenosine deaminase 1	502	55392	9.2	0	Nucleoplasm	NA	Specifically deaminates adenosine-37 to inosine in tRNA-Ala.	NA	Belongs to the ADAT1 family.	tRNA modification in the nucleus and cytosol	PE1	16
+NX_Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	465	51342	6.26	0	Nucleoplasm;Cytoplasm;Nucleus	NA	May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.	Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.;MKNK1 is phosphorylated by MAPK14 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	MAPK signaling pathway;Insulin signaling pathway;Spry regulation of FGF signaling	PE1	1
+NX_Q9BUB7	Transmembrane protein 70, mitochondrial	260	28969	9.02	2	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex V deficiency, nuclear type 2	Involved in biogenesis of mitochondrial ATP synthase.	NA	Belongs to the TMEM70 family.	NA	PE1	8
+NX_Q9BUD6	Spondin-2	331	35846	5.35	0	Cytoplasmic vesicle;Extracellular matrix	NA	Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).	NA	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	4
+NX_Q9BUE0	Mediator of RNA polymerase II transcription subunit 18	208	23663	6.06	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 18 family.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	1
+NX_Q9BUE6	Iron-sulfur cluster assembly 1 homolog, mitochondrial	129	14179	9.19	0	Mitochondrion	Multiple mitochondrial dysfunctions syndrome 5	Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.	NA	Belongs to the HesB/IscA family.	Mitochondrial iron-sulfur cluster biogenesis	PE1	9
+NX_Q9BUF5	Tubulin beta-6 chain	446	49857	4.77	0	Cytoskeleton	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	18
+NX_Q9BUF7	Protein crumbs homolog 3	120	12854	9.96	1	Apical cell membrane;Tight junction;Cell junction	NA	Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.	NA	NA	Tight junction;Tight junction interactions	PE1	19
+NX_Q9BUG6	Zinc finger and SCAN domain-containing protein 5A	496	55865	8.7	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	19
+NX_Q9BUH6	Protein PAXX	204	21640	5.39	0	Nucleoplasm;Nucleus	NA	Involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks in DNA. May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery.	NA	NA	NA	PE1	9
+NX_Q9BUH8	Brain-enriched guanylate kinase-associated protein	593	64803	5.4	0	Golgi apparatus;Cytoplasm;Membrane;Nucleoplasm;Cytosol	NA	May sustain the structure of the postsynaptic density (PSD).	NA	NA	Neurexins and neuroligins	PE1	14
+NX_Q9BUI4	DNA-directed RNA polymerase III subunit RPC3	534	60612	6.88	0	Nucleoplasm;Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628).	NA	Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	1
+NX_Q9BUJ0	Protein ABHD14A	271	29765	8.74	1	Membrane;Endoplasmic reticulum;Cytoplasm;Cytoplasmic vesicle	NA	Possible role in granule neuron development.	NA	Belongs to the AB hydrolase superfamily. ABHD14 family.	NA	PE1	3
+NX_Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	856	95739	6.49	0	Nucleoplasm;Nucleus	NA	Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.	Methylated.	NA	Influenza A;mRNA Splicing - Major Pathway	PE1	19
+NX_Q9BUK0	Coiled-coil-helix-coiled-coil-helix domain-containing protein 7	85	10095	9.1	0	Cytosol;Mitochondrion intermembrane space;Cell junction	NA	NA	NA	Belongs to the CHCHD7 family.	Mitochondrial protein import	PE1	8
+NX_Q9BUK6	Protein misato homolog 1	570	61835	5.7	0	Mitochondrion outer membrane;Cytoplasm;Nucleus	Myopathy, mitochondrial, and ataxia	Involved in the regulation of mitochondrial distribution and morphology (PubMed:17349998, PubMed:28554942, PubMed:28544275). Required for mitochondrial fusion and mitochondrial network formation (PubMed:28554942, PubMed:28544275).	NA	Belongs to the misato family.	NA	PE1	1
+NX_Q9BUL5	PHD finger protein 23	403	43818	5.62	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.	NA	Belongs to the PHF23 family.	NA	PE1	17
+NX_Q9BUL8	Programmed cell death protein 10	212	24702	7.8	0	Golgi apparatus membrane;Cytoplasm;Cell membrane	Cerebral cavernous malformations 3	Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).	NA	Belongs to the PDCD10 family.	NA	PE1	3
+NX_Q9BUL9	Ribonuclease P protein subunit p25	199	20632	9.66	0	Nucleoplasm;Centriolar satellite;Nucleolus	NA	Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).	NA	Belongs to the histone-like Alba family.	Ribosome biogenesis in eukaryotes;RNA transport;tRNA processing in the nucleus;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	15
+NX_Q9BUM1	Glucose-6-phosphatase 3	346	38735	8.47	9	Endoplasmic reticulum;Endoplasmic reticulum membrane	Neutropenia, severe congenital 4, autosomal recessive;Dursun syndrome	Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.	NA	Belongs to the glucose-6-phosphatase family.	Carbohydrate biosynthesis; gluconeogenesis.;Gluconeogenesis;Severe congenital neutropenia type 4 (G6PC3)	PE1	17
+NX_Q9BUN1	Protein MENT	341	36769	8.96	0	Secreted	NA	Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B.	Phosphorylation sites are present in the extracellular medium.	NA	NA	PE1	1
+NX_Q9BUN5	Coiled-coil domain-containing protein 28B	200	22037	5.23	0	Centrosome	Bardet-Biedl syndrome	Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex.	NA	NA	NA	PE1	1
+NX_Q9BUN8	Derlin-1	251	28801	9.54	4	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	(Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.;Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein (PubMed:15215856). Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).	NA	Belongs to the derlin family.	Protein processing in endoplasmic reticulum;Amyotrophic lateral sclerosis (ALS);ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;E3 ubiquitin ligases ubiquitinate target proteins	PE1	8
+NX_Q9BUP0	EF-hand domain-containing protein D1	239	26928	5.34	0	Golgi apparatus;Mitochondrion inner membrane;Nucleolus	NA	Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (PubMed:26975899). May play a role in neuronal differentiation (By similarity).	NA	NA	NA	PE1	2
+NX_Q9BUP3	Oxidoreductase HTATIP2	242	27049	8.58	0	Cytoplasm;Cytosol;Nucleus envelope	NA	Has an antiapoptotic effect.;Is a metastasis suppressor with proapoptotic as well as antiangiogenic properties.;Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import.	NA	NA	NA	PE1	11
+NX_Q9BUQ8	Probable ATP-dependent RNA helicase DDX23	820	95583	9.58	0	Nucleoplasm;Nucleolus;Nucleus	NA	Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation.	In vitro phosphorylated by CLK1 and U1 snRNP-associated protein kinase. Phosphorylated by SRPK2 and this phosphorylation is required for its association with the tri-snRNP (U4/U6-U5 tri-small nuclear ribonucleoproteins) and subsequent spliceosomal B complex formation.;DDX23 is phosphorylated by SRPK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	12
+NX_Q9BUR4	Telomerase Cajal body protein 1	548	59309	4.46	0	Cajal body;Chromosome;Nucleoplasm;Telomere;Cytosol;Nucleus	Dyskeratosis congenita, autosomal recessive, 3	RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29804836, PubMed:29695869). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29804836, PubMed:29695869). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493).	Phosphorylated at Ser-64 by ATM in response to DNA damage, promoting its interaction with histone H2AX/H2AFX and localization to sites of DNA double-strand breaks.	Belongs to the TCAB1 family.	Association of TriC/CCT with target proteins during biosynthesis;Telomere Extension By Telomerase	PE1	17
+NX_Q9BUR5	MICOS complex subunit MIC26	198	22285	9.18	1	Endoplasmic reticulum membrane;Mitochondrion;Secreted;Golgi apparatus membrane;Cytosol;Mitochondrion inner membrane	NA	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).	O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.	Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.	Cristae formation	PE1	X
+NX_Q9BUT1	3-hydroxybutyrate dehydrogenase type 2	245	26724	7.56	0	Cytoplasm;Cytosol	NA	Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Siderophore biosynthesis.;Synthesis and degradation of ketone bodies;Butanoate metabolism;Metabolic pathways;Synthesis of Ketone Bodies	PE1	4
+NX_Q9BUT9	MAPK regulated corepressor interacting protein 2	160	17828	9.5	0	Cytoplasm;Stress granule;Nucleus	NA	NA	NA	Belongs to the MCRIP family.	NA	PE1	16
+NX_Q9BUU2	Methyltransferase-like protein 22	404	44486	4.9	0	Nucleoplasm;Nucleus;Nucleolus	NA	Protein N-lysine methyltransferase. In vitro methylates KIN.	NA	Belongs to the methyltransferase superfamily. METTL22 family.	Protein methylation	PE1	16
+NX_Q9BUV0	Arginine/serine-rich protein 1	290	33613	11.76	0	Nucleoplasm	NA	NA	NA	Belongs to the RSRP family.	NA	PE1	1
+NX_Q9BUV8	Uncharacterized protein RAB5IF	137	15487	5.06	0	Cytosol	NA	NA	NA	NA	NA	PE1	20
+NX_Q9BUW7	UPF0184 protein C9orf16	83	9054	4.13	0	Cytoskeleton	NA	NA	NA	Belongs to the UPF0184 (EST00098) family.	NA	PE1	9
+NX_Q9BUX1	Glutathione-specific gamma-glutamylcyclotransferase 1	222	24418	5.05	0	trans-Golgi network;Cytosol;Mitochondrion	NA	Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).	NA	Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.	Glutathione synthesis and recycling	PE1	15
+NX_Q9BUY5	Zinc finger protein 426	554	63106	7.96	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	Generic Transcription Pathway	PE1	19
+NX_Q9BUY7	EF-hand calcium-binding domain-containing protein 11	163	19225	8.59	0	Cytosol;Cell junction	NA	NA	NA	NA	NA	PE1	14
+NX_Q9BUZ4	TNF receptor-associated factor 4	470	53543	8.54	0	Cytoplasm;Cell membrane;Tight junction;Perinuclear region;Nucleus;Cytoskeleton	NA	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.	Polyubiquitinated, leading to its proteasomal degradation.	Belongs to the TNF receptor-associated factor family. B subfamily.	Pathways in cancer;Small cell lung cancer	PE1	17
+NX_Q9BV10	Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase	488	54655	9.63	12	Endoplasmic reticulum;Endoplasmic reticulum membrane	Congenital disorder of glycosylation 1G	Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.	NA	Belongs to the glycosyltransferase 22 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG12 causes ALG12-CDG (CDG-1g)	PE1	22
+NX_Q9BV19	Uncharacterized protein C1orf50	199	21877	5.54	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q9BV20	Methylthioribose-1-phosphate isomerase	369	39150	5.89	0	Cytoplasm;Cell projection;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.	NA	Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.	Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.;Cysteine and methionine metabolism;Metabolic pathways;Methionine salvage pathway	PE1	19
+NX_Q9BV23	Monoacylglycerol lipase ABHD6	337	38331	8.67	1	Lysosome membrane;Nucleoplasm;Mitochondrion membrane;Cytoplasmic vesicle;Late endosome membrane	NA	Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015).	NA	Belongs to the AB hydrolase superfamily.	Arachidonate production from DAG	PE1	3
+NX_Q9BV29	Coiled-coil domain-containing protein 32	185	20656	4.42	0	Cytoplasmic vesicle;Nucleus speckle	NA	NA	NA	NA	NA	PE1	15
+NX_Q9BV35	Calcium-binding mitochondrial carrier protein SCaMC-3	468	52378	6.85	6	Mitochondrion inner membrane;Mitochondrion	NA	Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (PubMed:15123600). May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (PubMed:15123600). Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1 (PubMed:24430870).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	19
+NX_Q9BV36	Melanophilin	600	65949	5.73	0	Cytoplasm	Griscelli syndrome 3	Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.	NA	NA	NA	PE1	2
+NX_Q9BV38	WD repeat-containing protein 18	432	47405	6.21	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).	NA	Belongs to the WD repeat IPI3/WDR18 family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	19
+NX_Q9BV40	Vesicle-associated membrane protein 8	100	11438	6.73	1	Golgi apparatus;Cell membrane;Lysosome membrane;Nucleoplasm;Early endosome membrane;Late endosome membrane	NA	SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity).	NA	Belongs to the synaptobrevin family.	SNARE interactions in vesicular transport;ER-Phagosome pathway;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Neutrophil degranulation;trans-Golgi Network Vesicle Budding	PE1	2
+NX_Q9BV44	THUMP domain-containing protein 3	507	57003	5.97	0	Cytosol;Nucleolus	NA	NA	NA	Belongs to the methyltransferase superfamily.	NA	PE1	3
+NX_Q9BV47	Dual specificity protein phosphatase 26	211	23946	9.66	0	Golgi apparatus;Nucleoplasm;Cytoplasm;Nucleus	NA	Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	8
+NX_Q9BV57	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase	179	21498	5.43	0	Golgi apparatus;Cytoplasm;Cell membrane;Nucleoplasm;Nucleus	NA	Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.	NA	Belongs to the acireductone dioxygenase (ARD) family.	Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.;Cysteine and methionine metabolism;Metabolic pathways;Methionine salvage pathway	PE1	2
+NX_Q9BV68	E3 ubiquitin-protein ligase RNF126	311	33861	5.26	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174). Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174, PubMed:29042515). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).	Ubiquitinated. May undergo autoubiquitination.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	19
+NX_Q9BV73	Centrosome-associated protein CEP250	2442	281137	5	0	Centriole;Photoreceptor inner segment;Photoreceptor outer segment;Cilium basal body;Centrosome;Perinuclear region	Cone-rod dystrophy and hearing loss 2	May be involved in ciliogenesis (PubMed:28005958). Probably plays an important role in centrosome cohesion during interphase.	Differentially phosphorylated during cell cycle. Phosphorylation may regulate association/dissociation from centrosome. During M phase of mitosis, C-terminal part is phosphorylated by NEK2, suggesting that it may trigger the dissociation from the mitotic centrosome. Dephosphorylated in vitro by the PP1 phosphatase.;CEP250 is phosphorylated by STK3;CEP250 is phosphorylated by NEK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	20
+NX_Q9BV79	Enoyl-[acyl-carrier-protein] reductase, mitochondrial	373	40462	8.99	0	Cytoplasm;Mitochondrion;Nucleus	Dystonia, childhood-onset, with optic atrophy and basal ganglia abnormalities	Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16).	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.	Fatty acid elongation;Metabolic pathways;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	PE1	1
+NX_Q9BV81	ER membrane protein complex subunit 6	110	12017	10.08	2	Membrane;Nucleoplasm;Centrosome	NA	NA	NA	Belongs to the EMC6 family.	NA	PE1	17
+NX_Q9BV86	N-terminal Xaa-Pro-Lys N-methyltransferase 1	223	25387	5.32	0	Nucleoplasm;Cytosol;Nucleus	NA	Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.	NA	Belongs to the methyltransferase superfamily. NTM1 family.	NA	PE1	9
+NX_Q9BV87	Protein CNPPD1	410	45456	5.47	1	Membrane	NA	NA	NA	Belongs to the CNPPD1 family.	NA	PE1	2
+NX_Q9BV90	U11/U12 small nuclear ribonucleoprotein 25 kDa protein	132	15270	7.75	0	Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	NA	NA	NA	mRNA Splicing - Minor Pathway	PE1	16
+NX_Q9BV94	ER degradation-enhancing alpha-mannosidase-like protein 2	578	64753	5.16	0	Endoplasmic reticulum lumen	NA	Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity).	N-glycosylated.	Belongs to the glycosyl hydrolase 47 family.	Protein processing in endoplasmic reticulum;ER Quality Control Compartment (ERQC)	PE1	20
+NX_Q9BV97	KRAB domain-containing protein ZNF747	191	20610	10.78	0	NA	NA	NA	NA	NA	Generic Transcription Pathway	PE1	16
+NX_Q9BV99	Leucine-rich repeat-containing protein 61	259	28014	4.69	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	7
+NX_Q9BVA0	Katanin p80 WD40 repeat-containing subunit B1	655	72334	7.51	0	Cytoplasm;Cell membrane;Spindle pole;Centrosome;Cytosol;Spindle;Cytoskeleton	Lissencephaly 6, with microcephaly	Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.	NA	Belongs to the WD repeat KATNB1 family.	NA	PE1	16
+NX_Q9BVA1	Tubulin beta-2B chain	445	49953	4.78	0	Cytoskeleton	Cortical dysplasia, complex, with other brain malformations 7	Tubulin is the major constituent of microtubules (PubMed:23001566, PubMed:28013290, PubMed:26732629). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910).	Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).;Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.;TUBB2B is phosphorylated by PTK6	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	6
+NX_Q9BVA6	Protein adenylyltransferase FICD	458	51778	7.31	1	Nucleoplasm;Endoplasmic reticulum membrane	NA	Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083).	Auto-AMPylated in vitro; it is unclear whether auto-AMPylation is relevant in vivo.;N-glycosylated; predominantly glycosylated at Asn-275.	Belongs to the fic family.	NA	PE1	12
+NX_Q9BVC3	Sister chromatid cohesion protein DCC1	393	44825	5.05	0	Nucleoplasm;Nucleus	NA	Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.	NA	Belongs to the DCC1 family.	NA	PE1	8
+NX_Q9BVC4	Target of rapamycin complex subunit LST8	326	35876	5.5	0	Golgi apparatus;Nucleoplasm;Cell junction;Cytoplasm	NA	Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. MTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. MTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). MTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. MTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. MTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. MTORC2 promotes the serum-induced formation of stress-fibers or F-actin. MTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. MTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. MTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.	NA	Belongs to the WD repeat LST8 family.	mTOR signaling pathway;Macroautophagy;PIP3 activates AKT signaling;VEGFR2 mediated vascular permeability;CD28 dependent PI3K/Akt signaling;HSF1-dependent transactivation;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;Constitutive Signaling by AKT1 E17K in Cancer;mTOR signalling;mTORC1-mediated signalling;Regulation of TP53 Degradation;Regulation of PTEN gene transcription	PE1	16
+NX_Q9BVC5	Ashwin	232	25858	9.76	0	Cytoplasm;Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the ashwin family.	tRNA processing in the nucleus	PE1	2
+NX_Q9BVC6	Transmembrane protein 109	243	26210	10.48	3	Nucleus outer membrane;Endoplasmic reticulum membrane;Nucleus membrane;Cytosol;Sarcoplasmic reticulum membrane	NA	May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).	NA	NA	NA	PE1	11
+NX_Q9BVG3	E3 ubiquitin-protein ligase TRIM62	475	54268	6.17	0	Cytoplasm;Focal adhesion;Cytoplasmic vesicle	NA	E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.	Polyubiquitinated, autoubiquitinated in the presence of UBE2D2.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Interferon gamma signaling	PE1	1
+NX_Q9BVG4	Protein PBDC1	233	26057	4.72	0	Cytoplasm;Nucleoplasm;Nucleolus;Cytosol	NA	NA	NA	Belongs to the PBDC1 family.	NA	PE1	X
+NX_Q9BVG8	Kinesin-like protein KIFC3	833	92775	7.62	0	Cytoplasmic vesicle membrane;Adherens junction;Centrosome	NA	Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Association of TriC/CCT with target proteins during biosynthesis	PE1	16
+NX_Q9BVG9	Phosphatidylserine synthase 2	487	56253	5.86	7	Endoplasmic reticulum membrane	NA	Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine.	NA	Belongs to the phosphatidyl serine synthase family.	Phospholipid metabolism; phosphatidylserine biosynthesis.;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PS	PE1	11
+NX_Q9BVH7	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	336	38443	9.56	1	Cytoplasmic vesicle;Golgi apparatus membrane	NA	Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids than with glycoproteins (By similarity).	NA	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Sialic acid metabolism	PE1	1
+NX_Q9BVI0	PHD finger protein 20	1012	115386	6.55	0	Nucleoplasm;Cytosol;Nucleus membrane;Nucleus	NA	Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.	NA	NA	HATs acetylate histones;Stabilization of p53;Regulation of TP53 Degradation;Regulation of TP53 Activity through Association with Co-factors	PE1	20
+NX_Q9BVI4	Nucleolar complex protein 4 homolog	516	58468	7.08	3	Nucleoplasm;Nucleolus;Nucleus membrane	NA	NA	NA	Belongs to the CBF/MAK21 family.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	12
+NX_Q9BVJ6	U3 small nucleolar RNA-associated protein 14 homolog A	771	87978	7.67	0	Nucleolus	NA	May be required for ribosome biogenesis.	Citrullinated by PADI4.	Belongs to the UTP14 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	X
+NX_Q9BVJ7	Dual specificity protein phosphatase 23	150	16588	8.44	0	Nucleoplasm;Cytosol;Nucleus	NA	Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	1
+NX_Q9BVK2	Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase	526	60088	9.28	11	Nucleoplasm;Endoplasmic reticulum membrane	Polycystic liver disease 3 with or without kidney cysts;Congenital disorder of glycosylation 1H	Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it is transferred to the nascent peptide (By similarity). Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia (By similarity).	NA	Belongs to the ALG6/ALG8 glucosyltransferase family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG8 causes ALG8-CDG (CDG-1h)	PE1	11
+NX_Q9BVK6	Transmembrane emp24 domain-containing protein 9	235	27277	7.81	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;trans-Golgi network membrane;Endoplasmic reticulum membrane;cis-Golgi network membrane	NA	Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.	N-linked glycosylated containing high mannose.	Belongs to the EMP24/GP25L family.	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	5
+NX_Q9BVK8	Transmembrane protein 147	224	25261	7.61	6	Golgi apparatus;Endoplasmic reticulum membrane;Cytoskeleton	NA	NA	NA	NA	NA	PE1	19
+NX_Q9BVL2	Nucleoporin p58/p45	599	60897	9.36	0	Nucleus membrane;Nuclear pore complex	NA	Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.	O-glycosylated.	Belongs to the NUP58 family.	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	13
+NX_Q9BVL4	Protein adenylyltransferase SelO, mitochondrial	669	73489	5.69	0	Mitochondrion	NA	Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation) (PubMed:30270044). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein (PubMed:24751718).	NA	Belongs to the SELO family.	NA	PE1	22
+NX_Q9BVM2	Protein DPCD	203	23240	9.11	0	Nucleus speckle	NA	May play a role in the formation or function of ciliated cells.	NA	Belongs to the DPCD family.	NA	PE1	10
+NX_Q9BVM4	Gamma-glutamylaminecyclotransferase	153	17329	6.37	0	NA	NA	Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.	NA	Belongs to the gamma-glutamylcyclotransferase family.	NA	PE1	13
+NX_Q9BVN2	RUN and SH3 domain-containing protein 1	902	96444	5.9	0	Golgi apparatus;Cytoplasm;Early endosome;Postsynaptic density;Cytoplasmic vesicle;Cytosol;Nucleus;Cytoskeleton	NA	Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.	Polyubiquitinated; polyubiquitination involves TRAF6.;Phosphorylated on serine residues following nuclear translocation.	NA	NA	PE1	1
+NX_Q9BVP2	Guanine nucleotide-binding protein-like 3	549	61993	9.23	0	Nucleolus;Nucleus	NA	May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).	NA	Belongs to the TRAFAC class YlqF/YawG GTPase family.	Ribosome biogenesis in eukaryotes;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	3
+NX_Q9BVQ7	Spermatogenesis-associated protein 5-like protein 1	753	80710	8.42	0	Cytoplasm;Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the AAA ATPase family. AFG2 subfamily.	NA	PE1	15
+NX_Q9BVR0	Putative HERC2-like protein 3	1158	128943	6.45	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_Q9BVS4	Serine/threonine-protein kinase RIO2	552	63283	5.66	0	Cytoplasm;Cytosol;Cell membrane	NA	Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).	Autophosphorylated (in vitro) (PubMed:19564402, PubMed:21880710). Phosphorylation at Ser-335, Ser-380, Ser-548 by PLK1 affects the timing of the metaphase-anaphase transition (PubMed:21880710).	Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	Ribosome biogenesis in eukaryotes;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	5
+NX_Q9BVS5	tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial	477	52965	6.17	0	Cytosol;Mitochondrion	NA	Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.	tRNA modification in the mitochondrion	PE1	2
+NX_Q9BVT8	Transmembrane and ubiquitin-like domain-containing protein 1	246	26261	5.44	3	Cytoplasm;Postsynaptic cell membrane;Recycling endosome;Nucleolus;Membrane;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	IHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity).;Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as negative regulator of hepatocyte growth during regeneration (By similarity).	IHOPS: Processed by regulated intramembrane proteolysis (RIP)in the N-terminus to release iHOPS from membranes (By similarity).	NA	NA	PE1	7
+NX_Q9BVV2	Fibronectin type III domain-containing protein 11	318	36526	8.82	0	Nucleoplasm;Cytosol;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	20
+NX_Q9BVV6	Protein TALPID3	1533	169307	5.37	0	Centriole;Photoreceptor inner segment;Cilium basal body;Nucleoplasm;Centrosome;Cytosol	Short-rib thoracic dysplasia 14 with polydactyly;Joubert syndrome 23	Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity).	NA	Belongs to the TALPID3 family.	NA	PE1	14
+NX_Q9BVV7	Mitochondrial import inner membrane translocase subunit Tim21	248	28202	9.73	1	Mitochondrion membrane	NA	Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.	NA	Belongs to the TIM21 family.	Mitochondrial protein import	PE1	18
+NX_Q9BVV8	Protein FAM174C	132	14249	9.23	1	Membrane;Golgi apparatus;Nucleus speckle	NA	NA	NA	Belongs to the FAM174 family.	NA	PE1	19
+NX_Q9BVW5	TIMELESS-interacting protein	301	34555	4.73	0	Cytoplasm;Nucleus	NA	Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.	NA	Belongs to the CSM3 family.	Processing of DNA double-strand break ends	PE1	15
+NX_Q9BVW6	Small integral membrane protein 2	85	9520	5.19	1	Membrane;Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	13
+NX_Q9BVX2	Transmembrane protein 106C	250	27875	6.3	2	Membrane;Endoplasmic reticulum membrane	NA	NA	NA	Belongs to the TMEM106 family.	NA	PE1	12
+NX_Q9BW04	Specifically androgen-regulated gene protein	601	63964	8.78	0	Cytoplasm;Cytosol;Cell membrane	NA	Putative androgen-specific receptor.	NA	Belongs to the SARG family.	NA	PE1	1
+NX_Q9BW11	Max dimerization protein 3	206	23477	9.32	0	Nucleoplasm;Nucleolus;Nucleus	NA	Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).	NA	NA	NA	PE1	5
+NX_Q9BW19	Kinesin-like protein KIFC1	673	73748	9.15	0	Early endosome;Spindle;Centrosome;Nucleus	NA	Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	6
+NX_Q9BW27	Nuclear pore complex protein Nup85	656	75019	5.36	0	Cytoplasm;Nuclear pore complex;Nucleus membrane;Nucleoplasm;Cytosol;Spindle;Kinetochore	Nephrotic syndrome 17	Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872). As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus (PubMed:12718872). The Nup107-160 complex seems to be required for spindle assembly during mitosis (PubMed:16807356). NUP85 is required for membrane clustering of CCL2-activated CCR2 (PubMed:15995708). Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade (PubMed:15995708). Involved in nephrogenesis (PubMed:30179222).	NA	Belongs to the nucleoporin Nup85 family.	RNA transport;Separation of Sister Chromatids;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	17
+NX_Q9BW30	Tubulin polymerization-promoting protein family member 3	176	18985	9.19	0	Nucleolus;Cytoskeleton	NA	Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.	NA	Belongs to the TPPP family.	NA	PE1	16
+NX_Q9BW60	Elongation of very long chain fatty acids protein 1	279	32663	9.62	7	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.	NA	Belongs to the ELO family. ELOVL1 subfamily.	Lipid metabolism; fatty acid biosynthesis.;Fatty acid elongation;Synthesis of very long-chain fatty acyl-CoAs;Linoleic acid (LA) metabolism;alpha-linolenic acid (ALA) metabolism	PE1	1
+NX_Q9BW61	DET1- and DDB1-associated protein 1	102	11835	8.73	0	Nucleoplasm;Nucleolus	NA	May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.	NA	Belongs to the DDA1 family.	Neddylation	PE1	19
+NX_Q9BW62	Katanin p60 ATPase-containing subunit A-like 1	490	55392	6.35	0	Cytoplasm;Nucleoplasm;Spindle pole;Cytosol;Spindle;Cytoskeleton	NA	Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (PubMed:26929214).	NA	Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.	NA	PE1	13
+NX_Q9BW66	Cyclin-dependent kinase 2-interacting protein	212	24324	5.87	0	Nucleus	NA	Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.	Phosphorylated by CDC7 but not by CDK2.	Belongs to the CINP family.	NA	PE1	14
+NX_Q9BW71	HIRA-interacting protein 3	556	61957	8.71	0	Nucleoplasm;Nucleus	NA	May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.	Phosphorylated by CK2.	NA	NA	PE1	16
+NX_Q9BW72	HIG1 domain family member 2A, mitochondrial	106	11529	10.21	2	Mitochondrion membrane;Mitochondrion inner membrane	NA	Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes.	NA	NA	NA	PE1	5
+NX_Q9BW83	Intraflagellar transport protein 27 homolog	186	20480	5.28	0	Cytoplasm;Mitochondrion;Cilium;Nucleoplasm;Flagellum	Bardet-Biedl syndrome 19	Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).	NA	Belongs to the small GTPase superfamily. Rab family.	Intraflagellar transport	PE1	22
+NX_Q9BW85	Splicing factor YJU2	323	37086	5.75	0	Nucleoplasm;Nucleus	NA	Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:29301961). Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453).	NA	Belongs to the CWC16 family. YJU2 subfamily.	NA	PE1	19
+NX_Q9BW91	ADP-ribose pyrophosphatase, mitochondrial	350	39125	8.26	0	Nucleus membrane;Cell junction;Mitochondrion;Nucleus	NA	Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.	NA	Belongs to the Nudix hydrolase family. NudF subfamily.	Purine metabolism;Phosphate bond hydrolysis by NUDT proteins	PE1	4
+NX_Q9BW92	Threonine--tRNA ligase, mitochondrial	718	81036	6.9	0	Nucleoplasm;Mitochondrion matrix;Cytosol;Cytoskeleton	Combined oxidative phosphorylation deficiency 21	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain.	NA	Belongs to the class-II aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	1
+NX_Q9BWC9	Coiled-coil domain-containing protein 106	280	32032	9.47	0	Nucleoplasm;Cytosol;Nucleus	NA	Promotes the degradation of p53/TP53 protein and inhibits its transactivity.	NA	NA	NA	PE1	19
+NX_Q9BWD1	Acetyl-CoA acetyltransferase, cytosolic	397	41351	6.47	0	Nucleoplasm;Cytosol	NA	Involved in the biosynthetic pathway of cholesterol.	NA	Belongs to the thiolase-like superfamily. Thiolase family.	Lipid metabolism; fatty acid metabolism.;Fatty acid metabolism;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation;Lysine degradation;Tryptophan metabolism;Pyruvate metabolism;Glyoxylate and dicarboxylate metabolism;Propanoate metabolism;Butanoate metabolism;Terpenoid backbone biosynthesis;Metabolic pathways;Fat digestion and absorption;Cholesterol biosynthesis	PE1	6
+NX_Q9BWD3	Retrotransposon Gag-like protein 8A	113	13188	4.94	0	NA	NA	NA	NA	Belongs to the FAM127 family.	NA	PE1	X
+NX_Q9BWE0	Replication initiator 1	567	63575	10.05	0	Nucleoplasm;Nucleus	NA	Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending.	NA	NA	NA	PE1	7
+NX_Q9BWF2	E3 ubiquitin-protein ligase TRAIP	469	53294	8.75	0	Cytoplasm;Cell membrane;Nucleolus;Cytosol;Perinuclear region;Nucleus	Seckel syndrome 9	E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity) (PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase (PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is controversial (PubMed:26595769).	Autoubiquitinated.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	3
+NX_Q9BWF3	RNA-binding protein 4	364	40314	6.61	0	Cytoplasm;Nucleus speckle;Nucleolus;Cytoplasmic granule;Nucleus	NA	RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.	Phosphorylation on Ser-309 is induced upon cell muscle differentiation (By similarity). Phosphorylated. Phosphorylated in vitro on Ser-309 by SRPK1. Phosphorylation on Ser-309 is induced upon cell stress signaling, which alters its subcellular localization and may modulate its activity on IRES-mediated mRNA translation.	NA	Circadian Clock	PE1	11
+NX_Q9BWG4	Single-stranded DNA-binding protein 4	385	39388	6.3	0	Nucleus	NA	NA	NA	NA	NA	PE1	19
+NX_Q9BWG6	Sodium channel modifier 1	230	25949	9.03	0	Nucleoplasm;Nucleus speckle	NA	Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.	NA	NA	NA	PE1	1
+NX_Q9BWH2	FUN14 domain-containing protein 2	189	20676	9.74	0	Mitochondrion	NA	NA	NA	Belongs to the FUN14 family.	NA	PE1	X
+NX_Q9BWH6	RNA polymerase II-associated protein 1	1393	152755	5.95	0	Nucleoplasm;Cytosol;Nucleus	NA	Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3.	NA	Belongs to the RPAP1 family.	NA	PE1	15
+NX_Q9BWJ2	Putative uncharacterized protein encoded by RHPN1-AS1	59	6658	6.1	0	NA	NA	NA	NA	NA	NA	PE5	8
+NX_Q9BWJ5	Splicing factor 3B subunit 5	86	10135	5.89	0	Nucleoplasm;Nucleus	NA	Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937).	NA	Belongs to the SF3B5 family.	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	6
+NX_Q9BWK5	Cell cycle regulator of non-homologous end joining	157	16829	5.16	0	Cytoplasm;Nucleus	NA	Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974). May act as a regulator of proteasome (By similarity).;Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:24610814, PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974).	NA	NA	NA	PE1	7
+NX_Q9BWL3	Uncharacterized protein C1orf43	253	28779	9.61	1	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q9BWM5	Zinc finger protein 416	594	67188	8.33	0	Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9BWM7	Sideroflexin-3	321	35503	9.26	4	Mitochondrion membrane;Mitochondrion	NA	Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778).	NA	Belongs to the sideroflexin family.	NA	PE1	10
+NX_Q9BWN1	Proline-rich protein 14	585	64328	10.35	0	Nucleus lamina;Nucleoplasm;Nucleus;Chromosome	NA	Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574).	NA	NA	NA	PE1	16
+NX_Q9BWP8	Collectin-11	271	28665	5.26	0	Secreted	3MC syndrome 2	Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481).	NA	Belongs to the COLEC10/COLEC11 family.	Phagosome;Scavenging by Class A Receptors;Initial triggering of complement;Lectin pathway of complement activation	PE1	2
+NX_Q9BWQ6	Protein YIPF2	316	35151	5.43	5	Golgi apparatus;Mitochondrion;cis-Golgi network membrane;trans-Golgi network membrane;Late endosome membrane	NA	NA	NA	Belongs to the YIP1 family.	NA	PE1	19
+NX_Q9BWQ8	Protein lifeguard 2	316	35110	6.06	7	Postsynaptic cell membrane;Membrane raft;Cytoskeleton;Cell membrane	NA	Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.	NA	Belongs to the BI1 family. LFG subfamily.	NA	PE1	12
+NX_Q9BWS9	Chitinase domain-containing protein 1	393	44941	8.74	0	Nucleoplasm;Secreted;Cytoskeleton;Lysosome	NA	Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).	NA	Belongs to the glycosyl hydrolase 18 family.	Platelet degranulation	PE1	11
+NX_Q9BWT1	Cell division cycle-associated protein 7	371	42573	9.57	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Immunodeficiency-centromeric instability-facial anomalies syndrome 3	Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.	Phosphorylation at Thr-163 promotes interaction with YWHAE and YWHAZ, dissociation from MYC and sequestration in the cytoplasm. In vitro, phosphorylated at Thr-163 by AKT.	NA	NA	PE1	2
+NX_Q9BWT3	Poly(A) polymerase gamma	736	82803	9.21	0	Nucleoplasm;Nucleus	NA	Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.	NA	Belongs to the poly(A) polymerase family.	mRNA surveillance pathway	PE1	2
+NX_Q9BWT6	Meiotic nuclear division protein 1 homolog	205	23753	8.28	0	Nucleus	NA	Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.	NA	Belongs to the MND1 family.	Meiotic recombination	PE1	4
+NX_Q9BWT7	Caspase recruitment domain-containing protein 10	1032	115931	5.74	0	Cytoplasmic vesicle;Cytoplasm;Cytosol;Cytoskeleton	NA	Activates NF-kappa-B via BCL10 and IKK.	NA	NA	NA	PE1	22
+NX_Q9BWU0	Kanadaptin	796	88814	5.11	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	NA	NA	NA	NA	PE1	2
+NX_Q9BWU1	Cyclin-dependent kinase 19	502	56802	8.66	0	Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	6
+NX_Q9BWV1	Brother of CDO	1114	121059	6.58	1	Nucleoplasm;Cell membrane	NA	Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.	N-glycosylated.	NA	Activation of SMO;Ligand-receptor interactions;Myogenesis	PE1	3
+NX_Q9BWV2	Spermatogenesis-associated protein 9	254	28740	9.53	1	Membrane;Mitochondrion	NA	May play a role in testicular development/spermatogenesis and may be an important factor in male infertility.	NA	NA	NA	PE1	5
+NX_Q9BWV3	Cytidine and dCMP deaminase domain-containing protein 1	514	58455	8.34	0	Nucleoplasm	NA	May play an important role in testicular development and spermatogenesis.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	NA	PE1	13
+NX_Q9BWV7	Probable tubulin polyglutamylase TTLL2	592	67336	9	0	Nucleolus;Nucleus membrane	NA	Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).	NA	Belongs to the tubulin--tyrosine ligase family.	Carboxyterminal post-translational modifications of tubulin	PE1	6
+NX_Q9BWW4	Single-stranded DNA-binding protein 3	388	40421	6.4	0	Nucleus	NA	May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.	NA	NA	NA	PE1	1
+NX_Q9BWW7	Transcriptional repressor scratch 1	348	35570	9.56	0	Nucleus	NA	Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation.	NA	Belongs to the snail C2H2-type zinc-finger protein family.	NA	PE1	8
+NX_Q9BWW8	Apolipoprotein L6	343	38128	8.58	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	NA	Belongs to the apolipoprotein L family.	NA	PE1	22
+NX_Q9BWW9	Apolipoprotein L5	433	47044	9.39	0	Cytoplasm	NA	May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.	NA	Belongs to the apolipoprotein L family.	NA	PE2	22
+NX_Q9BWX1	PHD finger protein 7	381	43767	8.58	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	May play a role in spermatogenesis.	NA	NA	NA	PE1	3
+NX_Q9BWX5	Transcription factor GATA-5	397	41299	9.17	0	Nucleoplasm;Cytosol;Nucleus	Congenital heart defects, multiple types, 5	Transcription factor required during cardiovascular development (PubMed:23289003). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed:25543888).	NA	NA	Factors involved in megakaryocyte development and platelet production	PE1	20
+NX_Q9BX10	GTP-binding protein 2	602	65768	8.32	0	Cytoplasm;Cytoplasmic vesicle	Jaberi-Elahi syndrome	NA	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.	Platelet degranulation	PE1	6
+NX_Q9BX26	Synaptonemal complex protein 2	1530	175639	9.01	0	Cell membrane;Chromosome;Nucleoplasm;Cytosol;Nucleus	NA	Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.	Phosphorylated.	Belongs to the SYCP2 family.	Meiotic synapsis	PE1	20
+NX_Q9BX40	Protein LSM14 homolog B	385	42071	9.69	0	Cytoplasmic vesicle;Nucleolus	NA	May play a role in control of mRNA translation.	NA	Belongs to the LSM14 family.	NA	PE1	20
+NX_Q9BX46	RNA-binding protein 24	236	24776	8.52	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29358667, PubMed:29104163). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed:29104163). Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (PubMed:20977548, PubMed:24356969). Involved in myogenic differentiation by regulating MYOG levels (PubMed:20977548). Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization (PubMed:24375645). Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (PubMed:29104163). Plays a role in the regulation of mRNA translation (PubMed:29358667). Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (PubMed:29358667). Binds to a huge amount of mRNAs (PubMed:29104163). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity).	NA	NA	NA	PE1	6
+NX_Q9BX51	Glutathione hydrolase light chain 1	225	24274	5	0	NA	NA	NA	NA	Belongs to the gamma-glutamyltransferase family.	NA	PE2	20
+NX_Q9BX59	Tapasin-related protein	468	50183	5.12	1	Microsome membrane;Golgi apparatus membrane;Endoplasmic reticulum membrane;Cell membrane	NA	Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).	NA	NA	NA	PE1	12
+NX_Q9BX63	Fanconi anemia group J protein	1249	140867	6.49	0	Nucleoplasm;Cytoplasm;Nucleus membrane;Nucleus	Breast cancer;Fanconi anemia complementation group J	DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.	Phosphorylated. Phosphorylation is necessary for interaction with BRCA1, and is cell-cycle regulated.;Acetylation at Lys-1249 facilitates DNA end processing required for repair and checkpoint signaling.	Belongs to the DEAD box helicase family. DEAH subfamily.	Fanconi anemia pathway;G2/M DNA damage checkpoint;Cytosolic iron-sulfur cluster assembly;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	17
+NX_Q9BX66	Sorbin and SH3 domain-containing protein 1	1292	142513	6.4	0	Cell membrane;Nucleus matrix;Adherens junction;Focal adhesion;Centrosome;Nucleus;Cytoskeleton	NA	Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).	O-glycosylated.	NA	PPAR signaling pathway;Adherens junction;Insulin signaling pathway;Smooth Muscle Contraction	PE1	10
+NX_Q9BX67	Junctional adhesion molecule C	310	35020	7.53	1	Golgi apparatus;Desmosome;Cell membrane;Cell junction;Secreted;Tight junction	Hemorrhagic destruction of the brain with subependymal calcification and cataracts	Soluble form of JAM-C: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis.;Mediates cell-cell adhesion (PubMed:11590146, PubMed:12208882, PubMed:15194813). Functions as counter-receptor for JAM2 (PubMed:11590146). Functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). May play a role in the regulation of cell migration (Probable). Required for normal polarization and acrosome formation in developing spermatids, and for normal male fertility (By similarity).	S-palmitoylated by ZDHHC7. S-palmitoylation promotes expression at tight junctions.;Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by proinflammatory factors.	Belongs to the immunoglobulin superfamily.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Epithelial cell signaling in Helicobacter pylori infection;Integrin cell surface interactions;Cell surface interactions at the vascular wall	PE1	11
+NX_Q9BX68	Histidine triad nucleotide-binding protein 2, mitochondrial	163	17162	9.2	0	Mitochondrion	NA	Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.	NA	Belongs to the HINT family.	NA	PE1	9
+NX_Q9BX69	Caspase recruitment domain-containing protein 6	1037	116468	5.98	0	NA	NA	May be involved in apoptosis.	NA	NA	NOD-like receptor signaling pathway	PE1	5
+NX_Q9BX70	BTB/POZ domain-containing protein 2	525	55931	5.63	0	Cytoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q9BX73	TM2 domain-containing protein 2	214	22871	4.83	2	Membrane;Nucleoplasm;Cytoplasmic vesicle;Cell membrane	NA	NA	NA	Belongs to the TM2 family.	NA	PE1	8
+NX_Q9BX74	TM2 domain-containing protein 1	207	22327	6.09	2	Membrane	NA	May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42.	N-glycosylated.	Belongs to the TM2 family.	NA	PE1	1
+NX_Q9BX79	Receptor for retinol uptake STRA6	667	73503	9.18	9	Cell membrane	Microphthalmia, syndromic, 9	Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:9452451, PubMed:18316031, PubMed:22665496). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031).	Phosphorylated on tyrosine residues in response to RBP4 binding (PubMed:21368206, PubMed:22665496). Phosphorylation requires the presence of LRAT, suggesting it may be triggered by the uptake of retinol that is then metabolized within the cell to retinoids that function as signaling molecules (PubMed:22665496).	NA	The canonical retinoid cycle in rods (twilight vision);Retinoid cycle disease events	PE1	15
+NX_Q9BX82	Zinc finger protein 471	626	73009	8.88	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9BX84	Transient receptor potential cation channel subfamily M member 6	2022	231708	7.86	6	Cell membrane	Hypomagnesemia 1	Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.	NA	In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily.;In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.	Mineral absorption;TRP channels	PE1	9
+NX_Q9BX93	Group XIIB secretory phospholipase A2-like protein	195	21659	5.75	0	Secreted	NA	Not known; does not seem to have catalytic activity.	NA	Belongs to the phospholipase A2 family.	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis	PE1	10
+NX_Q9BX95	Sphingosine-1-phosphate phosphatase 1	441	49108	9.08	9	Nucleoplasm;Endoplasmic reticulum membrane;Cell membrane	NA	Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:12815058, PubMed:11756451, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic retiulum to the Golgi apparatus (PubMed:16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:20798685, PubMed:18583713). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity).	NA	Belongs to the type 2 lipid phosphate phosphatase family.	Sphingolipid metabolism;Sphingolipid de novo biosynthesis	PE1	14
+NX_Q9BX97	Plasmalemma vesicle-associated protein	442	50594	9.01	1	Cell membrane;Centrosome;Caveola;Cytosol;Perinuclear region	Diarrhea 10, protein-losing enteropathy type	Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.	NA	NA	NA	PE1	19
+NX_Q9BXA5	Succinate receptor 1	334	38698	9.14	7	Cell membrane	NA	Receptor for succinate.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Class A/1 (Rhodopsin-like receptors)	PE1	3
+NX_Q9BXA6	Testis-specific serine/threonine-protein kinase 6	273	30331	9.24	0	NA	NA	Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).	Autophosphorylated.;Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	19
+NX_Q9BXA7	Testis-specific serine/threonine-protein kinase 1	367	41618	7.6	0	Cytoplasm;Acrosome;Flagellum	NA	Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.	Autophosphorylated.;Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	5
+NX_Q9BXA9	Sal-like protein 3	1300	135346	6.56	0	Nucleus	NA	Probable transcription factor.	NA	Belongs to the sal C2H2-type zinc-finger protein family.	NA	PE1	18
+NX_Q9BXB1	Leucine-rich repeat-containing G-protein coupled receptor 4	951	104475	5.78	7	Centriolar satellite;Cell membrane	Osteoporosis	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	Regulation of FZD by ubiquitination	PE1	11
+NX_Q9BXB4	Oxysterol-binding protein-related protein 11	747	83643	6.6	0	Golgi apparatus;Nucleoplasm;trans-Golgi network membrane;Late endosome membrane	NA	Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).	NA	Belongs to the OSBP family.	NA	PE1	3
+NX_Q9BXB5	Oxysterol-binding protein-related protein 10	764	83970	8.56	0	Golgi apparatus;Cytosol;Cytoskeleton;Cell membrane	NA	Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110).	NA	Belongs to the OSBP family.	Acyl chain remodelling of PS	PE1	3
+NX_Q9BXB7	Spermatogenesis-associated protein 16	569	65263	9.21	0	Golgi apparatus	Spermatogenic failure 6	Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion.	NA	Belongs to the SPATA16 family.	NA	PE1	3
+NX_Q9BXC0	Hydroxycarboxylic acid receptor 1	346	39295	9.14	7	Cell membrane	NA	Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Hydroxycarboxylic acid-binding receptors	PE1	12
+NX_Q9BXC1	Probable G-protein coupled receptor 174	333	38503	8.73	7	Cytoplasmic vesicle;Cell membrane	NA	Putative receptor for purines coupled to G-proteins.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	X
+NX_Q9BXC9	Bardet-Biedl syndrome 2 protein	721	79871	5.74	0	Cilium membrane;Cytoplasm;Centriolar satellite	Retinitis pigmentosa 74;Bardet-Biedl syndrome 2	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.	NA	NA	BBSome-mediated cargo-targeting to cilium	PE1	16
+NX_Q9BXD5	N-acetylneuraminate lyase	320	35163	5.4	0	Cytoplasm;Cell membrane;Cytoplasmic vesicle	NA	Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity).	NA	Belongs to the DapA family. NanA subfamily.	Amino-sugar metabolism; N-acetylneuraminate degradation.;Amino sugar and nucleotide sugar metabolism;Sialic acid metabolism	PE1	1
+NX_Q9BXE9	Vomeronasal type-1 receptor 3	311	34713	9.83	7	Cell membrane	NA	Putative pheromone receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	16
+NX_Q9BXF3	Cat eye syndrome critical region protein 2	1484	164213	6.51	0	Nucleoplasm;Cytoplasmic vesicle	NA	Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex (PubMed:15640247, PubMed:26365797, PubMed:22464331). It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797, PubMed:22464331). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed:11827465).	NA	NA	NA	PE1	22
+NX_Q9BXF6	Rab11 family-interacting protein 5	653	70415	9.28	0	Cytoplasm;Centriolar satellite;Secretory vesicle membrane;Recycling endosome membrane;Golgi apparatus membrane;Early endosome membrane;Cytoplasmic vesicle;Mitochondrion membrane	NA	Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.	Phosphorylated on serine and threonine residues. Phosphorylation at Ser-357 is PKA-dependent.	NA	Endocytosis	PE1	2
+NX_Q9BXF9	Tektin-3	490	56636	6.93	0	Flagellum;Acrosome outer membrane	NA	May be a structural component of the sperm flagellum. Required for normal sperm mobility.	N- and O-glycosylated.;May be proteolytically processed during the epididymal transit of spermatozoa.	Belongs to the tektin family.	NA	PE1	17
+NX_Q9BXG8	Spermatogenic leucine zipper protein 1	430	49445	7.21	0	Cytoplasm;Nucleus	NA	Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity).	Phosphorylated by MAPK1/ERK2 and MAPK3/ERK1.	NA	NA	PE1	5
+NX_Q9BXH1	Bcl-2-binding component 3, isoforms 1/2	193	20532	9.09	0	Cytosol;Mitochondrion	NA	Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338).	NA	Belongs to the Bcl-2 family.	p53 signaling pathway;Huntington's disease;Measles;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Activation of PUMA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;FOXO-mediated transcription of cell death genes	PE1	19
+NX_Q9BXI2	Mitochondrial ornithine transporter 2	301	32580	9.22	6	Mitochondrion inner membrane	NA	Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Urea cycle	PE1	5
+NX_Q9BXI3	Cytosolic 5'-nucleotidase 1A	368	41021	6.11	0	Cytoplasm	NA	Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.	NA	Belongs to the 5'-nucleotidase type 3 family.	Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Pyrimidine catabolism;Purine catabolism	PE1	1
+NX_Q9BXI6	TBC1 domain family member 10A	508	57118	8.69	0	Microvillus;Cell membrane	NA	Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A.	Exists in both phosphorylated and non-phosphorylated state.	NA	TBC/RABGAPs	PE1	22
+NX_Q9BXI9	Complement C1q tumor necrosis factor-related protein 6	278	30861	5.92	0	Nucleoplasm;Secreted	NA	NA	NA	NA	NA	PE1	22
+NX_Q9BXJ0	Complement C1q tumor necrosis factor-related protein 5	243	25298	6.05	0	Secreted	Late-onset retinal degeneration	NA	NA	NA	NA	PE1	11
+NX_Q9BXJ1	Complement C1q tumor necrosis factor-related protein 1	281	31743	6.42	0	Nucleoplasm;Cytosol;Secreted	NA	NA	NA	NA	NA	PE1	17
+NX_Q9BXJ2	Complement C1q tumor necrosis factor-related protein 7	289	30683	5.11	0	Cytoplasmic vesicle;Secreted	NA	NA	NA	NA	NA	PE1	4
+NX_Q9BXJ3	Complement C1q tumor necrosis factor-related protein 4	329	35256	8.38	0	Secreted	NA	May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity).	NA	NA	NA	PE1	11
+NX_Q9BXJ4	Complement C1q tumor necrosis factor-related protein 3	246	26994	6.04	0	Golgi apparatus;Secreted	NA	NA	Glycosylated on Asn-70.	NA	NA	PE1	5
+NX_Q9BXJ5	Complement C1q tumor necrosis factor-related protein 2	285	29952	9.04	0	Secreted	NA	NA	NA	NA	NA	PE1	5
+NX_Q9BXJ7	Protein amnionless	453	47754	5.76	1	Endosome membrane;Cell membrane;Coated pit;Secreted;Apical cell membrane	Recessive hereditary megaloblastic anemia 1	Membrane-bound component of the endocytic receptor formed by AMN and CUBN (PubMed:14576052, PubMed:30523278, PubMed:29402915). Required for normal CUBN glycosylation and trafficking to the cell surface (PubMed:14576052, PubMed:29402915). The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052, PubMed:26040326). Required for normal CUBN-mediated protein transport in the kidney (Probable).	N-glycosylated.;A soluble form arises by proteolytic removal of the membrane anchor.	NA	Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective AMN causes hereditary megaloblastic anemia 1;Defective CUBN causes hereditary megaloblastic anemia 1;HDL clearance	PE1	14
+NX_Q9BXJ8	Transmembrane protein 120A	343	40610	9.14	5	Nucleus inner membrane	NA	Necessary for efficient adipogenesis (PubMed:26024229).	NA	Belongs to the TMEM120 family.	NA	PE1	7
+NX_Q9BXJ9	N-alpha-acetyltransferase 15, NatA auxiliary subunit	866	101272	7.23	0	Cytoplasm;Cytosol;Nucleus	Mental retardation, autosomal dominant 50	Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.	Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.	NA	NA	PE1	4
+NX_Q9BXK1	Krueppel-like factor 16	252	25431	9.95	0	Nucleoplasm;Nucleus	NA	Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity).	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q9BXK5	Bcl-2-like protein 13	485	52723	4.41	1	Mitochondrion membrane;Mitochondrion;Nucleus	NA	May promote the activation of caspase-3 and apoptosis.	NA	Belongs to the Bcl-2 family.	Legionellosis	PE1	22
+NX_Q9BXL5	Hemogen	484	55341	4.82	0	Nucleoplasm;Nucleus	NA	Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).	NA	NA	NA	PE1	9
+NX_Q9BXL6	Caspase recruitment domain-containing protein 14	1004	113270	5.65	0	Cytoplasm	Pityriasis rubra pilaris;Psoriasis 2	Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359).;Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.	NA	NA	NA	PE1	17
+NX_Q9BXL7	Caspase recruitment domain-containing protein 11	1154	133284	5.78	0	Cytoplasm;Membrane raft	Immunodeficiency 11 A;Immunodeficiency 11B with atopic dermatitis;B-cell expansion with NFKB and T-cell anergy	Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway.	Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.	NA	T cell receptor signaling pathway;B cell receptor signaling pathway;Activation of NF-kappaB in B cells;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Downstream TCR signaling	PE1	7
+NX_Q9BXL8	Cell division cycle-associated protein 4	241	26114	4.86	0	Nucleoplasm;Cytosol;Nucleus	NA	May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).	NA	NA	NA	PE1	14
+NX_Q9BXM0	Periaxin	1461	154905	7.22	0	Cytoplasm;Golgi apparatus;Cell membrane;Cell junction;Cytoplasmic vesicle;Nucleus	Charcot-Marie-Tooth disease 4F;Dejerine-Sottas syndrome	Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology.	NA	Belongs to the periaxin family.	NA	PE1	19
+NX_Q9BXM7	Serine/threonine-protein kinase PINK1, mitochondrial	581	62769	9.43	1	Mitochondrion outer membrane;Cytosol;Mitochondrion inner membrane	Parkinson disease 6	Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).	Two shorter forms of 55 kDa and 48 kDa seem to be produced by proteolytic cleavage and localize mainly in cytosol.;Autophosphorylation at Ser-228 and Ser-402 is essential for Parkin/PRKN recruitment to depolarized mitochondria.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	Parkinson's disease;Pink/Parkin Mediated Mitophagy;FOXO-mediated transcription of cell death genes	PE1	1
+NX_Q9BXM9	FSD1-like protein	530	59578	5.86	0	Cytoskeleton;Cell membrane	NA	NA	NA	NA	NA	PE1	9
+NX_Q9BXN1	Asporin	380	43417	6.61	0	Extracellular matrix	Intervertebral disc disease;Osteoarthritis 3	Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.	There is no serine/glycine dipeptide sequence expected for the attachment of O-linked glycosaminoglycans and this is probably not a proteoglycan. The O-linked polysaccharide on 54-Ser is probably the mucin type linked to GalNAc.;The N-linked glycan at Asn-282 is composed of variable structures of GlcNAc, mannose, fucose, HexNAc and hexose.	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	ECM proteoglycans	PE1	9
+NX_Q9BXN2	C-type lectin domain family 7 member A	247	27627	5.21	1	Cytoplasm;Cell membrane	Candidiasis, familial, 4	Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).	Phosphorylated on tyrosine residues in response to glucan binding.	NA	Phagosome;Tuberculosis;CLEC7A (Dectin-1) signaling	PE1	12
+NX_Q9BXN6	Sperm protein associated with the nucleus on the X chromosome D	97	11029	5.87	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the SPAN-X family.	NA	PE1	X
+NX_Q9BXP2	Solute carrier family 12 member 9	914	96110	8.35	12	Cell membrane	NA	May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function.	NA	Belongs to the SLC12A transporter family.	NA	PE1	7
+NX_Q9BXP5	Serrate RNA effector molecule homolog	876	100666	5.7	0	Cytoplasm;Nucleoplasm	NA	Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).	NA	Belongs to the ARS2 family.	mRNA Splicing - Major Pathway;RNA polymerase II transcribes snRNA genes	PE1	7
+NX_Q9BXP8	Pappalysin-2	1791	198539	5.26	0	Endoplasmic reticulum;Secreted;Cytoplasmic vesicle	NA	Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.	NA	Belongs to the peptidase M43B family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	PE1	1
+NX_Q9BXQ6	Transmembrane protein 121B	578	58425	9.35	0	Cytoplasmic vesicle;Nucleoplasm;Cell membrane	NA	NA	NA	Belongs to the TMEM121 family.	NA	PE1	22
+NX_Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	403	44048	6.82	0	Mitochondrion outer membrane;Cytoplasm;Mitochondrion	NA	Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity).	NA	Belongs to the queuine tRNA-ribosyltransferase family.	tRNA modification in the nucleus and cytosol	PE1	19
+NX_Q9BXR3	Endogenous retrovirus group K member 6 Pol protein	956	107688	9.07	0	NA	NA	Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	Cleavage sites that yield the mature proteins remain to be determined.	Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.	NA	PE2	7
+NX_Q9BXR5	Toll-like receptor 10	811	94564	6.32	1	Membrane;Cytosol;Centrosome	NA	Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).	NA	Belongs to the Toll-like receptor family.	IRAK4 deficiency (TLR5);MyD88 cascade initiated on plasma membrane;Toll Like Receptor 10 (TLR10) Cascade	PE1	4
+NX_Q9BXR6	Complement factor H-related protein 5	569	64419	6.81	0	Secreted	CFHR5 deficiency	Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH.	NA	NA	Regulation of Complement cascade	PE1	1
+NX_Q9BXS0	Collagen alpha-1(XXV) chain	654	64771	8.6	1	Membrane;Cytoplasmic vesicle;Cytosol;Endoplasmic reticulum	Fibrosis of extraocular muscles, congenital, 5	Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.	Hydroxylated on 11% of proline residues and 49% of lysine residues.;Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.;Glycosylated.	NA	Collagen degradation;Collagen biosynthesis and modifying enzymes;Collagen chain trimerization	PE1	4
+NX_Q9BXS1	Isopentenyl-diphosphate delta-isomerase 2	227	26753	6.01	0	Peroxisome	NA	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).	NA	Belongs to the IPP isomerase type 1 family.	Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.;Terpenoid backbone biosynthesis;Metabolic pathways;Cholesterol biosynthesis	PE1	10
+NX_Q9BXS4	Transmembrane protein 59	323	36223	5	1	Lysosome membrane;Cell membrane;Late endosome membrane;Golgi apparatus membrane	NA	Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).	N-glycosylated.	Belongs to the TMEM59 family.	NA	PE1	1
+NX_Q9BXS5	AP-1 complex subunit mu-1	423	48587	6.82	0	Golgi apparatus;Clathrin-coated vesicle membrane	NA	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.	Belongs to the adaptor complexes medium subunit family.	Lysosome;MHC class II antigen presentation;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Nef mediated downregulation of MHC class I complex cell surface expression;Neutrophil degranulation	PE1	19
+NX_Q9BXS6	Nucleolar and spindle-associated protein 1	441	49452	9.92	0	Cytoplasm;Nucleolus;Chromosome;Nucleoplasm;Spindle	NA	Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.	Ubiquitinated. Ubiquitination by FZR1 may lead to proteasome-dependent degradation of this protein.;Phosphorylation by ATM in G2/M-phase induces mitotic arrest.	Belongs to the NUSAP family.	NA	PE1	15
+NX_Q9BXS9	Solute carrier family 26 member 6	759	82967	8.57	8	Microsome;Cell membrane;Basolateral cell membrane;Membrane;Cytoplasmic vesicle membrane;Cytosol;Apical cell membrane	NA	Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.;Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.	Phosphorylated on serine residues by PKC; the phosphorylation disrupts interaction with carbonic anhydrase CA2 and reduces bicarbonate transport activity in a phorbol myristate acetate (PMA)-induced manner.	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Mineral absorption;Multifunctional anion exchangers	PE1	3
+NX_Q9BXT2	Voltage-dependent calcium channel gamma-6 subunit	260	28129	9.4	4	Cytosol;Nucleolus;Cell membrane	NA	Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.	NA	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	19
+NX_Q9BXT4	Tudor domain-containing protein 1	1180	132024	5.96	0	Cytoplasm	NA	Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).	NA	Belongs to the TDRD1 family.	PIWI-interacting RNA (piRNA) biogenesis	PE1	10
+NX_Q9BXT5	Testis-expressed protein 15	2789	315336	5.81	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Spermatogenic failure 25	Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair.	NA	Belongs to the TEX15 family.	Meiotic recombination	PE1	8
+NX_Q9BXT6	RNA helicase Mov10l1	1211	135293	6.07	0	Cytoplasm	NA	ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.	NA	Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.	PIWI-interacting RNA (piRNA) biogenesis	PE1	22
+NX_Q9BXT8	RING finger protein 17	1623	184643	5.27	0	Cytoplasm;Nucleus	NA	Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity).	NA	NA	NA	PE1	13
+NX_Q9BXU0	Testis-expressed protein 12	123	14107	5.22	0	NA	NA	NA	NA	NA	Meiotic synapsis	PE1	11
+NX_Q9BXU1	Serine/threonine-protein kinase 31	1019	115694	5.04	0	NA	NA	NA	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	7
+NX_Q9BXU2	Testis-expressed protein 13B	312	33967	5.79	0	NA	NA	NA	NA	Belongs to the TEX13 family.	NA	PE1	X
+NX_Q9BXU3	Testis-expressed protein 13A	409	45583	5.36	0	NA	NA	NA	NA	Belongs to the TEX13 family.	NA	PE1	X
+NX_Q9BXU7	Ubiquitin carboxyl-terminal hydrolase 26	913	104047	8.91	0	Nucleus	NA	Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.	NA	Belongs to the peptidase C19 family.	Ub-specific processing proteases	PE1	X
+NX_Q9BXU8	Ferritin heavy polypeptide-like 17	183	21142	6.05	0	NA	NA	NA	NA	Belongs to the ferritin family.	NA	PE1	X
+NX_Q9BXU9	Calcium-binding protein 8	219	24837	4.76	1	Cytoplasmic vesicle;trans-Golgi network membrane;Perinuclear region;Cell membrane	NA	Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning.	NA	NA	NA	PE1	7
+NX_Q9BXV9	EKC/KEOPS complex subunit GON7	100	10859	4.08	0	Nucleoplasm;Nucleolus;Nucleus	NA	Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.	NA	NA	NA	PE1	14
+NX_Q9BXW3	Putative uncharacterized protein SNHG12	62	6988	4.63	0	NA	NA	NA	NA	NA	NA	PE5	1
+NX_Q9BXW4	Microtubule-associated proteins 1A/1B light chain 3C	147	16852	9.14	0	Autophagosome membrane;Endomembrane system;Autophagosome;Cytosol;Cytoskeleton	NA	Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643).	The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).;The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.	Belongs to the ATG8 family.	Macroautophagy	PE1	1
+NX_Q9BXW6	Oxysterol-binding protein-related protein 1	950	108470	5.96	0	Nucleoplasm;Cytosol;Late endosome	NA	Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).	NA	Belongs to the OSBP family.	MHC class II antigen presentation;Synthesis of bile acids and bile salts	PE1	18
+NX_Q9BXW7	Haloacid dehalogenase-like hydrolase domain-containing 5	423	46321	8.38	0	Mitochondrion	NA	NA	NA	Belongs to the HAD-like hydrolase superfamily.	NA	PE1	22
+NX_Q9BXW9	Fanconi anemia group D2 protein	1451	164128	5.58	0	Nucleoplasm;Nucleus;Nucleolus;Cytosol	Fanconi anemia complementation group D2	Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.	Monoubiquitinated on Lys-561 during S phase and upon genotoxic stress by FANCL in complex with E2 ligases UBE2T or UBE2W (isoform 1 and isoform 2). Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the joint intervention of the FANC core complex, including FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, and FANCM, and proteins involved in cell cycle checkpoints and DNA repair, including RPA1, ATR, CHEK1 and BRCA1, and is mediated by FANCL/PHF9. Ubiquitination is required for binding to chromatin, interaction with BRCA1, BRCA2 and MTMR15/FAN1, DNA repair, and normal cell cycle progression, but not for phosphorylation on Ser-222 or interaction with MEN1.;Phosphorylated in response to various genotoxic stresses by ATM and/or ATR. Upon ionizing radiation, phosphorylated by ATM on Ser-222 and Ser-1404. Phosphorylation on Ser-222 is required for S-phase checkpoint activation, but not for ubiquitination, foci formation, or DNA repair. In contrast, phosphorylation by ATR on other sites may be required for ubiquitination and foci formation.	NA	Fanconi anemia pathway;Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes	PE1	3
+NX_Q9BXX0	EMILIN-2	1053	115687	6.04	0	Extracellular matrix	NA	May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.	NA	NA	Molecules associated with elastic fibres	PE1	18
+NX_Q9BXX2	Ankyrin repeat domain-containing protein 30B	1392	158049	6.01	0	NA	NA	NA	NA	NA	NA	PE1	18
+NX_Q9BXX3	Ankyrin repeat domain-containing protein 30A	1397	158835	6.08	0	NA	NA	NA	NA	NA	NA	PE1	10
+NX_Q9BXY0	Protein MAK16 homolog	300	35369	5.27	0	Cytoplasmic vesicle;Nucleolus	NA	NA	NA	Belongs to the MAK16 family.	NA	PE1	8
+NX_Q9BXY4	R-spondin-3	272	30929	9.53	0	Secreted	NA	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) (PubMed:21727895, PubMed:21909076, PubMed:22615920). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720).	NA	Belongs to the R-spondin family.	Regulation of FZD by ubiquitination;RUNX1 regulates transcription of genes involved in WNT signaling	PE1	6
+NX_Q9BXY5	Calcyphosin-2	557	63835	8.87	0	Nucleoplasm;Centrosome;Nucleolus	NA	NA	NA	NA	NA	PE1	12
+NX_Q9BXY8	Protein BEX2	128	15321	5.89	0	Cytoplasm;Nucleus	NA	Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.	NA	Belongs to the BEX family.	NA	PE1	X
+NX_Q9BY07	Electrogenic sodium bicarbonate cotransporter 4	1137	126255	8.1	12	Apical cell membrane	NA	Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.	NA	Belongs to the anion exchanger (TC 2.A.31) family.	Bile secretion;Bicarbonate transporters	PE1	2
+NX_Q9BY08	Emopamil-binding protein-like	206	23204	5.91	4	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Does not possess sterol isomerase activity and does not bind sigma ligands.	NA	Belongs to the EBP family.	NA	PE1	13
+NX_Q9BY10	Thymic stromal cotransporter homolog	475	51067	9.18	12	Cell membrane	NA	May act as a transporter.	Glycosylated.	Belongs to the major facilitator superfamily. SLC46A family.	NA	PE1	9
+NX_Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	444	50966	5.15	0	Cytoplasm;Cell membrane;Synaptosome;Cell projection;Membrane;Nucleoplasm;Cytoplasmic vesicle membrane;Synapse;Ruffle membrane;Cytoplasmic vesicle;Cytosol	NA	Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.	Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).	Belongs to the PACSIN family.	Clathrin-mediated endocytosis	PE1	6
+NX_Q9BY12	S phase cyclin A-associated protein in the endoplasmic reticulum	1400	158287	7.21	0	Endoplasmic reticulum;Nucleoplasm;Cytosol;Nucleus	Intellectual developmental disorder and retinitis pigmentosa	CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.	Phosphorylated in vitro by the CCNA2/CDK2 complex.	NA	NA	PE1	15
+NX_Q9BY14	Testis-expressed protein 101	249	26667	4.9	0	Cell membrane;Secreted;Cytoplasmic vesicle;Membrane raft;Acrosome	NA	Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity).	Sheds from membrane raft by ACE and released from the cell surface of epididymal sperm while it passes through the caput epididymis leading to disappearance of TEX101 on spermatozoa; is essential to produce fertile spermatozoa.;N-glycosylated; by high mannose and/or biantennary complex and/or certain types of hybrid oligosaccharides; possesses different oligosaccharides chains according to its subcellular localization in the testis.	NA	Post-translational modification: synthesis of GPI-anchored proteins	PE1	19
+NX_Q9BY15	Adhesion G protein-coupled receptor E3	652	72621	8.41	7	Secreted;Cell membrane	NA	Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils.	Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	Class B/2 (Secretin family receptors);Neutrophil degranulation	PE1	19
+NX_Q9BY19	Membrane-spanning 4-domains subfamily A member 8	250	26290	5.76	4	Membrane	NA	May be involved in signal transduction as a component of a multimeric receptor complex.	NA	Belongs to the MS4A family.	NA	PE2	11
+NX_Q9BY21	G-protein coupled receptor 87	358	41436	9.55	7	Nucleoplasm;Mitochondrion;Lipid droplet;Cell membrane	NA	Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	3
+NX_Q9BY27	Protein DGCR6L	220	24932	7.02	0	Nucleus	NA	May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.	NA	Belongs to the gonadal family.	NA	PE1	22
+NX_Q9BY31	Zinc finger protein 717	904	105251	8.91	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	3
+NX_Q9BY32	Inosine triphosphate pyrophosphatase	194	21446	5.5	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Inosine triphosphate pyrophosphohydrolase deficiency;Epileptic encephalopathy, early infantile, 35	Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.	NA	Belongs to the HAM1 NTPase family.	Purine metabolism;Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Purine catabolism	PE1	20
+NX_Q9BY41	Histone deacetylase 8	377	41758	5.36	0	Nucleoplasm;Cytoplasm;Nucleus;Cell membrane	Cornelia de Lange syndrome 5;Wilson-Turner X-linked mental retardation syndrome	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.	Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4.	Belongs to the histone deacetylase family. HD type 1 subfamily.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HDACs deacetylate histones;Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	PE1	X
+NX_Q9BY42	Replication termination factor 2	306	33887	8.87	0	Nucleoplasm;Nucleolus;Chromosome	NA	Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612).	Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability.	Belongs to the rtf2 family.	NA	PE1	20
+NX_Q9BY43	Charged multivesicular body protein 4a	222	25098	4.65	0	Cytoplasmic vesicle membrane;Late endosome membrane	NA	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).	NA	Belongs to the SNF7 family.	Endocytosis;Macroautophagy;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	14
+NX_Q9BY44	Eukaryotic translation initiation factor 2A	585	64990	9	0	Cytosol;Mitochondrion	NA	Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	EIF2A is phosphorylated by MAPK3	Belongs to the WD repeat EIF2A family.	NA	PE1	3
+NX_Q9BY49	Peroxisomal trans-2-enoyl-CoA reductase	303	32544	8.97	0	Peroxisome	NA	Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Lipid metabolism; fatty acid biosynthesis.;Biosynthesis of unsaturated fatty acids;Peroxisome;Alpha-oxidation of phytanate;Peroxisomal protein import	PE1	2
+NX_Q9BY50	Signal peptidase complex catalytic subunit SEC11C	192	21542	9.2	1	Microsome membrane;Endoplasmic reticulum membrane	NA	Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.	NA	Belongs to the peptidase S26B family.	Protein export;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);SRP-dependent cotranslational protein targeting to membrane;Synthesis, secretion, and deacylation of Ghrelin	PE1	18
+NX_Q9BY60	Gamma-aminobutyric acid receptor-associated protein-like 3	117	13976	8.71	0	Autophagosome membrane;Cytoskeleton	NA	Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).	The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL3-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (By similarity).	Belongs to the ATG8 family.	Macroautophagy	PE2	15
+NX_Q9BY64	UDP-glucuronosyltransferase 2B28	529	60906	8.84	1	Microsome membrane;Endoplasmic reticulum membrane	NA	UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	4
+NX_Q9BY65	Nasopharyngeal carcinoma down-regulated gene protein 1	106	11990	7.72	0	NA	NA	NA	NA	NA	NA	PE4	3
+NX_Q9BY66	Lysine-specific demethylase 5D	1539	174073	5.59	0	Nucleolus;Nucleus	NA	Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.	NA	Belongs to the JARID1 histone demethylase family.	HDMs demethylate histones	PE1	Y
+NX_Q9BY67	Cell adhesion molecule 1	442	48509	4.94	1	Cell junction;Synapse;Cell membrane	NA	Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.	Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction.	Belongs to the nectin family.	Cell adhesion molecules (CAMs);Adherens junctions interactions;Nectin/Necl trans heterodimerization	PE1	11
+NX_Q9BY71	Leucine-rich repeat-containing protein 3	257	28108	6.45	1	Membrane	NA	NA	NA	Belongs to the LRRC3 family.	NA	PE1	21
+NX_Q9BY76	Angiopoietin-related protein 4	406	45214	9.07	0	Nucleoplasm;Extracellular matrix;Secreted;Cytoplasmic vesicle	NA	ANGPTL4 N-terminal chain: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). Has higher activity in LPL inactivation than the uncleaved protein (PubMed:19270337, PubMed:21398697).;Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17068295). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (PubMed:17068295). Depending on context, may modulate tumor-related angiogenesis (By similarity).	ANGPTL4 N-terminal chain: Forms disulfide-linked dimers and tetramers.;Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain; both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell.;N-glycosylated.	NA	PPAR signaling pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation;Assembly of active LPL and LIPC lipase complexes	PE1	19
+NX_Q9BY77	Polymerase delta-interacting protein 3	421	46089	10	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex.	Phosphorylated at Ser-383 and Ser-385 by RPS6KB1.	NA	Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	22
+NX_Q9BY78	E3 ubiquitin-protein ligase RNF26	433	47737	8.86	5	Cytoplasmic vesicle;Nucleoplasm;Endoplasmic reticulum membrane;Cytosol	NA	E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102). Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 (PubMed:27368102). Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379). Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379).	NA	NA	Protein modification; protein ubiquitination.	PE1	11
+NX_Q9BY79	Membrane frizzled-related protein	579	62212	4.84	1	Apical cell membrane	Microphthalmia, isolated, 5;Nanophthalmos 2	May play a role in eye development.	NA	NA	NA	PE1	11
+NX_Q9BY84	Dual specificity protein phosphatase 16	665	73102	7.24	0	Cytoplasmic vesicle;Nucleoplasm;Cytoplasm;Nucleus	NA	Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.	Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity.;(Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein; this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis.	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway;RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway	PE1	12
+NX_Q9BY89	Uncharacterized protein KIAA1671	1806	196711	8.69	0	Cytoskeleton	NA	NA	NA	NA	NA	PE1	22
+NX_Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	1731	184667	8.99	0	Cytoplasm;Dendritic spine;Cell membrane;Nucleoplasm;Postsynaptic density	Schizophrenia 15;Phelan-McDermid syndrome	Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.	NA	NA	RET signaling;Neurexins and neuroligins	PE1	22
+NX_Q9BYB4	Guanine nucleotide-binding protein subunit beta-like protein 1	327	35618	8.27	0	Cytosol	NA	NA	NA	NA	NA	PE1	22
+NX_Q9BYC2	Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial	517	56140	6.73	0	Mitochondrion	NA	Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).	NA	Belongs to the 3-oxoacid CoA-transferase family.	Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation;Butanoate metabolism;Utilization of Ketone Bodies	PE1	1
+NX_Q9BYC5	Alpha-(1,6)-fucosyltransferase	575	66516	7.36	1	Nucleoplasm;Golgi apparatus;Cytosol;Golgi stack membrane	Congenital disorder of glycosylation with defective fucosylation 1	Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.	Tyrosine phosphorylated by PKDCC/VLK.	Belongs to the glycosyltransferase 23 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Glycosaminoglycan biosynthesis - keratan sulfate;Metabolic pathways;Reactions specific to the complex N-glycan synthesis pathway	PE1	14
+NX_Q9BYC8	39S ribosomal protein L32, mitochondrial	188	21405	9.78	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bL32 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	7
+NX_Q9BYC9	39S ribosomal protein L20, mitochondrial	149	17443	10.87	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bL20 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	1
+NX_Q9BYD1	39S ribosomal protein L13, mitochondrial	178	20692	9.18	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL13 family.	Ribosome;Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	8
+NX_Q9BYD2	39S ribosomal protein L9, mitochondrial	267	30243	10.09	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bL9 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	1
+NX_Q9BYD3	39S ribosomal protein L4, mitochondrial	311	34919	9.73	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL4 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	19
+NX_Q9BYD5	Cornifelin	112	12376	5.7	0	Cytoplasm;Cytoskeleton	NA	Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.	NA	Belongs to the cornifelin family.	NA	PE1	19
+NX_Q9BYD6	39S ribosomal protein L1, mitochondrial	325	36909	8.88	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL1 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	4
+NX_Q9BYD9	Actin-related protein T3	372	41008	5.53	0	Nucleoplasm;Cytoplasm;Nucleus;Cytoskeleton	NA	NA	NA	Belongs to the actin family.	NA	PE1	3
+NX_Q9BYE0	Transcription factor HES-7	225	24899	10.49	0	Nucleoplasm;Nucleus;Nucleolus	Spondylocostal dysostosis 4, autosomal recessive	Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation (By similarity).	NA	NA	NA	PE1	17
+NX_Q9BYE2	Transmembrane protease serine 13	586	63167	8.96	1	Membrane	NA	NA	NA	Belongs to the peptidase S1 family.	Influenza A	PE1	11
+NX_Q9BYE3	Late cornified envelope protein 3D	92	9444	9.03	0	NA	NA	Precursors of the cornified envelope of the stratum corneum.	NA	Belongs to the LCE family.	Formation of the cornified envelope	PE1	1
+NX_Q9BYE4	Small proline-rich protein 2G	73	8158	8.3	0	Cytoplasm	NA	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).	NA	Belongs to the cornifin (SPRR) family.	Formation of the cornified envelope	PE1	1
+NX_Q9BYE7	Polycomb group RING finger protein 6	350	39047	4.92	0	Nucleus	NA	Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).	Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro.	NA	Transcriptional Regulation by E2F6	PE1	10
+NX_Q9BYE9	Cadherin-related family member 2	1310	141543	4.31	1	Apical cell membrane;Cell junction;Microvillus membrane	NA	Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771).	NA	NA	NA	PE1	5
+NX_Q9BYF1	Angiotensin-converting enzyme 2	805	92463	5.36	1	Cytoplasm;Secreted;Cell membrane	NA	(Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV.;Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (PubMed:10969042, PubMed:10924499, PubMed:11815627). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency (PubMed:11815627). By cleavage of angiotensin II, may be an important regulator of heart function (PubMed:10969042, PubMed:10924499). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity (PubMed:18424768, PubMed:19185582).;(Microbial infection) Acts as a receptor for Human coronavirus NL63/HCoV-NL63.	N-glycosylation on Asn-90 may limit SARS infectivity.;Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.	Belongs to the peptidase M2 family.	Renin-angiotensin system;Protein digestion and absorption;Metabolism of Angiotensinogen to Angiotensins	PE1	X
+NX_Q9BYG0	Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase	378	44053	8	1	Nucleolus;Golgi apparatus membrane	NA	Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;O-linked glycosylation of mucins	PE1	3
+NX_Q9BYG3	MKI67 FHA domain-interacting nucleolar phosphoprotein	293	34222	9.88	0	Nucleus;Nucleolus;Chromosome	NA	NA	Sequentially phosphorylated on Thr-238, Thr-234 and Ser-230. Thr-234 is phosphorylated only when Thr-238 is phosphorylated. Likewise, phosphorylation at Ser-230 requires that Thr-234 and Thr-238 are phosphorylated. Phosphorylation enhances MKI67 binding.	NA	NA	PE1	2
+NX_Q9BYG4	Partitioning defective 6 homolog gamma	376	40883	8.36	0	Cytoplasm;Tight junction;Cell membrane	NA	Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity).	NA	Belongs to the PAR6 family.	Endocytosis;Tight junction;Tight junction interactions	PE1	18
+NX_Q9BYG5	Partitioning defective 6 homolog beta	372	41182	5.37	0	Cytoplasm;Tight junction;Cytosol;Cell membrane	NA	Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.	NA	Belongs to the PAR6 family.	Endocytosis;Tight junction;Tight junction interactions	PE1	20
+NX_Q9BYG7	Protein maestro	248	29054	9.93	0	Nucleolus	NA	NA	NA	NA	NA	PE2	18
+NX_Q9BYG8	Gasdermin-C	508	57692	5.55	0	Cytosol;Mitochondrion;Cell membrane	NA	The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown (Probable).	NA	Belongs to the gasdermin family.	NA	PE1	8
+NX_Q9BYH1	Seizure 6-like protein	1024	111782	4.68	1	Cytoplasmic vesicle;Endoplasmic reticulum membrane	NA	May contribute to specialized endoplasmic reticulum functions in neurons.	O-glycosylated.	Belongs to the SEZ6 family.	NA	PE1	22
+NX_Q9BYH8	NF-kappa-B inhibitor zeta	718	78061	6.15	0	Cytosol;Nucleus speckle;Nucleus	NA	Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity).	NA	NA	NA	PE1	3
+NX_Q9BYI3	Hyccin	521	57625	8.45	0	Cytosol;Cell membrane	Leukodystrophy, hypomyelinating, 5	Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway (Probable).	NA	Belongs to the FAM126 family.	NA	PE1	7
+NX_Q9BYJ0	Fibroblast growth factor-binding protein 2	223	24581	9.15	0	Extracellular space	NA	NA	NA	Belongs to the fibroblast growth factor-binding protein family.	FGFR2b ligand binding and activation	PE1	4
+NX_Q9BYJ1	Hydroperoxide isomerase ALOXE3	711	80543	6.53	0	Cytoplasm;Cytosol;Cell membrane	Ichthyosis, congenital, autosomal recessive 3	Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.	NA	Belongs to the lipoxygenase family.	Lipid metabolism; sphingolipid metabolism.;Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.;Synthesis of 12-eicosatetraenoic acid derivatives	PE1	17
+NX_Q9BYJ4	Tripartite motif-containing protein 34	488	56864	7.43	0	Cytoplasm;Centrosome;Nucleolus	NA	May function as antiviral protein and may contribute to the defense against retroviral infections.	NA	Belongs to the TRIM/RBCC family.	Interferon gamma signaling	PE1	11
+NX_Q9BYJ9	YTH domain-containing family protein 1	559	60874	8.86	0	Cytoplasm	NA	Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440). Required to facilitate learning and memory formation in the hippocampus by enhancing protein synthesis upon neuronal stimulation: in response to neuronal stimulation, binds to m6A-containing neuronal mRNAs, promoting their translation, thereby contributing to learning and memory (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts, thereby promoting their translation (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). Acts by binding and promoting translation of m6A-containing transcripts encoding proteins involved in lysosomal degradation and phagosome maturation, leading to increased antigen degradation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity).	NA	NA	NA	PE1	20
+NX_Q9BYK8	Helicase with zinc finger domain 2	2649	294651	7.36	0	Nucleus	NA	Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.	NA	Belongs to the DNA2/NAM7 helicase family.	PPARA activates gene expression;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PE1	20
+NX_Q9BYL1	Sterile alpha motif domain-containing protein 10	202	22770	10.02	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	20
+NX_Q9BYM8	RanBP-type and C3HC4-type zinc finger-containing protein 1	510	57572	5.47	0	NA	Polyglucosan body myopathy 1 with or without immunodeficiency	E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.	Auto-ubiquitinated. Auto-ubiquitination leads to degradation by the proteasome (By similarity).;Phosphorylated. In vitro, phosphorylation inhibits auto-ubiquitination activity (By similarity).	Belongs to the RBR family.	Antigen processing: Ubiquitination &amp; Proteasome degradation;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway	PE1	20
+NX_Q9BYN0	Sulfiredoxin-1	137	14259	7.92	0	Cytoplasm;Nucleus	NA	Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.	NA	Belongs to the sulfiredoxin family.	NA	PE1	20
+NX_Q9BYN7	Zinc finger protein 341	854	92728	9.11	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	Hyper-IgE recurrent infection syndrome 3, autosomal recessive	Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	20
+NX_Q9BYN8	28S ribosomal protein S26, mitochondrial	205	24212	10.39	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mS26 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	20
+NX_Q9BYP7	Serine/threonine-protein kinase WNK3	1800	198416	5.77	0	Cytoplasm;Cytoplasmic vesicle	NA	Stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.;Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.	Ubiquitinated by the BCR(KLHL2) complex, leading to its degradation.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.	Stimuli-sensing channels	PE1	X
+NX_Q9BYP8	Keratin-associated protein 17-1	105	9504	3.83	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	NA	Keratinization	PE2	17
+NX_Q9BYP9	Keratin-associated protein 9-9	154	16266	8.22	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 9 family.	Keratinization	PE1	17
+NX_Q9BYQ0	Keratin-associated protein 9-8	159	16723	8.04	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 9 family.	Keratinization	PE1	17
+NX_Q9BYQ2	Keratin-associated protein 9-4	154	16378	7.95	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 9 family.	Keratinization	PE1	17
+NX_Q9BYQ3	Keratin-associated protein 9-3	159	16854	7.93	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 9 family.	Keratinization	PE1	17
+NX_Q9BYQ4	Keratin-associated protein 9-2	174	18287	8.15	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 9 family.	Keratinization	PE1	17
+NX_Q9BYQ5	Keratin-associated protein 4-6	205	21825	8.43	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 4 family.	Keratinization	PE1	17
+NX_Q9BYQ6	Keratin-associated protein 4-11	195	20927	8.4	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 4 family.	Keratinization	PE1	17
+NX_Q9BYQ7	Keratin-associated protein 4-1	146	15241	8.15	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 4 family.	Keratinization	PE1	17
+NX_Q9BYQ8	Keratin-associated protein 4-9	210	22405	8.29	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 4 family.	Keratinization	PE1	17
+NX_Q9BYQ9	Keratin-associated protein 4-8	185	19627	8.21	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 4 family.	Keratinization	PE1	17
+NX_Q9BYR0	Keratin-associated protein 4-7	210	22535	8.31	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 4 family.	Keratinization	PE1	17
+NX_Q9BYR2	Keratin-associated protein 4-5	181	19363	8.25	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 4 family.	Keratinization	PE1	17
+NX_Q9BYR3	Keratin-associated protein 4-4	166	18023	8.39	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 4 family.	Keratinization	PE1	17
+NX_Q9BYR4	Keratin-associated protein 4-3	195	20504	8.43	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 4 family.	Keratinization	PE1	17
+NX_Q9BYR5	Keratin-associated protein 4-2	136	14462	8.31	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 4 family.	Keratinization	PE1	17
+NX_Q9BYR6	Keratin-associated protein 3-3	98	10365	5.4	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 3 family.	Keratinization	PE1	17
+NX_Q9BYR7	Keratin-associated protein 3-2	98	10407	5.4	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 3 family.	Keratinization	PE1	17
+NX_Q9BYR8	Keratin-associated protein 3-1	98	10539	5.99	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 3 family.	Keratinization	PE1	17
+NX_Q9BYR9	Keratin-associated protein 2-4	128	13480	8.32	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the KRTAP type 2 family.	Keratinization	PE1	17
+NX_Q9BYS1	Keratin-associated protein 1-5	174	18010	6.59	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	NA	Belongs to the KRTAP type 1 family.	Keratinization	PE1	17
+NX_Q9BYS8	Leucine-rich repeat-containing protein 2	371	42943	5.79	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	3
+NX_Q9BYT1	Solute carrier family 17 member 9	436	47482	7.96	10	Membrane;Nucleoplasm	Porokeratosis 8, disseminated superficial actinic type	Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles.	NA	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.	NA	PE1	20
+NX_Q9BYT3	Serine/threonine-protein kinase 33	514	57831	6.6	0	Nucleoplasm;Cytosol;Perinuclear region;Nucleolus	NA	Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.	Autophosphorylated.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	NA	PE1	11
+NX_Q9BYT5	Keratin-associated protein 2-2	123	12957	8.26	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the KRTAP type 2 family.	Keratinization	PE2	17
+NX_Q9BYT8	Neurolysin, mitochondrial	704	80652	6.21	0	Cytoplasm;Mitochondrion intermembrane space;Mitochondrion	NA	Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.	NA	Belongs to the peptidase M3 family.	Renin-angiotensin system;Peptide ligand-binding receptors	PE1	5
+NX_Q9BYT9	Anoctamin-3	981	114657	8.87	8	Cell membrane	Dystonia 24	Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:21984732).	NA	Belongs to the anoctamin family.	Stimuli-sensing channels	PE1	11
+NX_Q9BYU1	Pre-B-cell leukemia transcription factor 4	374	40854	9.05	0	Cytoplasmic vesicle;Nucleus	NA	NA	NA	Belongs to the TALE/PBX homeobox family.	NA	PE1	19
+NX_Q9BYU5	Keratin-associated protein 2-1	128	13514	8.32	0	NA	NA	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).	NA	Belongs to the KRTAP type 2 family.	Keratinization	PE2	17
+NX_Q9BYV1	Alanine--glyoxylate aminotransferase 2, mitochondrial	514	57156	8.08	0	Mitochondrion	NA	Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.	NA	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Alanine, aspartate and glutamate metabolism;Glycine, serine and threonine metabolism;Metabolic pathways;Pyrimidine catabolism;Glyoxylate metabolism and glycine degradation	PE1	5
+NX_Q9BYV2	Tripartite motif-containing protein 54	358	40301	5.15	0	Cytosol;Z line;Cytoskeleton;Cell membrane	NA	May bind and stabilize microtubules during myotubes formation.	NA	NA	NA	PE1	2
+NX_Q9BYV6	Tripartite motif-containing protein 55	548	60466	4.74	0	Golgi apparatus;Cytoplasm;Cytosol;Nucleus	NA	May regulate gene expression and protein turnover in muscle cells.	NA	NA	NA	PE1	8
+NX_Q9BYV7	Beta,beta-carotene 9',10'-oxygenase	579	65674	8.65	0	Mitochondrion	NA	Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects.	NA	Belongs to the carotenoid oxygenase family.	Retinoid metabolism and transport	PE1	11
+NX_Q9BYV8	Centrosomal protein of 41 kDa	373	41368	8.46	0	Centrosome;Cilium;Cilium basal body	Joubert syndrome 15	Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium.	NA	Belongs to the CEP41 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	7
+NX_Q9BYV9	Transcription regulator protein BACH2	841	92537	5	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Immunodeficiency 60	Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713).	The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses.;Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.	Belongs to the bZIP family. CNC subfamily.	NA	PE1	6
+NX_Q9BYW1	Solute carrier family 2, facilitated glucose transporter member 11	496	53703	8.57	12	Nucleoplasm;Cell junction;Cell membrane	NA	Facilitative glucose transporter.	NA	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Cellular hexose transport	PE1	22
+NX_Q9BYW2	Histone-lysine N-methyltransferase SETD2	2564	287597	5.8	0	Cytosol;Nucleus speckle;Nucleus;Chromosome	Luscan-Lumish syndrome;Leukemia, acute lymphoblastic;Leukemia, acute myelogenous;Renal cell carcinoma	Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426).;(Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.	May be automethylated.	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	Lysine degradation;PKMTs methylate histone lysines	PE1	3
+NX_Q9BYW3	Beta-defensin 126	111	12174	9.47	0	Secreted	NA	Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (By similarity). In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (PubMed:19373462, PubMed:23229569).	O-glycosylated; glycans contain alpha(2,3)-linked sialic acids.	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	20
+NX_Q9BYX2	TBC1 domain family member 2A	928	105414	6.15	0	Cytoplasm;Cell junction;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.	NA	NA	TBC/RABGAPs	PE1	9
+NX_Q9BYX4	Interferon-induced helicase C domain-containing protein 1	1025	116689	5.38	0	Cytoplasm;Nucleus	Singleton-Merten syndrome 1;Aicardi-Goutieres syndrome 7;Diabetes mellitus, insulin-dependent, 19	Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.	Ubiquitinated by RNF125, leading to its degradation by the proteasome (PubMed:17460044). USP17/UPS17L2-dependent deubiquitination positively regulates the receptor (PubMed:20368735). Ubiquitinated by TRIM25 via 'Lys-63'-linked ubiquitination, promoting activation of IFIH1/MDA5 (PubMed:30193849).;During apoptosis, processed into 3 cleavage products. The helicase-containing fragment, once liberated from the CARD domains, translocate from the cytoplasm to the nucleus. The processed protein significantly sensitizes cells to DNA degradation.;Sumoylated. Sumoylation positively regulates its role in type I interferon induction and is enhanced by PIAS2-beta.	Belongs to the helicase family. RLR subfamily.	RIG-I-like receptor signaling pathway;Measles;Influenza A;Herpes simplex infection;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling;TRAF3-dependent IRF activation pathway;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Ub-specific processing proteases;Ovarian tumor domain proteases	PE1	2
+NX_Q9BYX7	Putative beta-actin-like protein 3	375	42016	5.91	0	Cytoskeleton	NA	NA	Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).;Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.	Belongs to the actin family.	Platelet degranulation	PE5	2
+NX_Q9BYZ2	L-lactate dehydrogenase A-like 6B	381	41943	8.88	0	NA	NA	NA	NA	Belongs to the LDH/MDH superfamily. LDH family.	Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.;Glycolysis / Gluconeogenesis;Cysteine and methionine metabolism;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Pyruvate metabolism	PE1	15
+NX_Q9BYZ6	Rho-related BTB domain-containing protein 2	727	82626	6.27	0	Cell membrane	Epileptic encephalopathy, early infantile, 64	NA	NA	Belongs to the small GTPase superfamily. Rho family.	Ubiquitin mediated proteolysis;Rho GTPase cycle	PE1	8
+NX_Q9BYZ8	Regenerating islet-derived protein 4	158	18230	9.33	0	Secreted	NA	Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.	NA	NA	NA	PE1	1
+NX_Q9BZ11	Disintegrin and metalloproteinase domain-containing protein 33	813	87739	6.54	1	Membrane;Nucleus speckle;Cell membrane	Asthma	NA	The precursor is cleaved by a furin endopeptidase.	NA	NA	PE1	20
+NX_Q9BZ19	Ankyrin repeat domain-containing protein 60	345	37630	9.2	0	NA	NA	NA	NA	NA	NA	PE1	20
+NX_Q9BZ23	Pantothenate kinase 2, mitochondrial	570	62681	9.39	0	Cytoplasm;Cytosol;Mitochondrion	Neurodegeneration with brain iron accumulation 1;Hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration	May be the master regulator of the CoA biosynthesis.	NA	Belongs to the type II pantothenate kinase family.	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.;Pantothenate and CoA biosynthesis;Metabolic pathways;Coenzyme A biosynthesis	PE1	20
+NX_Q9BZ29	Dedicator of cytokinesis protein 9	2069	236446	7.25	0	Endomembrane system	NA	Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.	NA	Belongs to the DOCK family.	Factors involved in megakaryocyte development and platelet production	PE1	13
+NX_Q9BZ67	FERM domain-containing protein 8	464	51218	5.83	0	Nucleoplasm;Cytosol;Nucleolus;Cell membrane	NA	Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019).	NA	NA	NA	PE1	11
+NX_Q9BZ68	Putative FERM domain-containing protein FRMD8P1	369	41136	5.54	0	NA	NA	NA	NA	NA	NA	PE5	X
+NX_Q9BZ71	Membrane-associated phosphatidylinositol transfer protein 3	974	106781	6.69	0	Endomembrane system;Cell membrane	Cone-rod dystrophy 5	Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions.	NA	Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.	Synthesis of PI	PE1	17
+NX_Q9BZ72	Membrane-associated phosphatidylinositol transfer protein 2	1349	148933	6.72	0	Cytoplasmic vesicle;Endomembrane system	NA	Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions.	NA	Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.	Synthesis of PI	PE1	12
+NX_Q9BZ76	Contactin-associated protein-like 3	1288	140690	8.02	1	Secreted;Cell membrane	NA	NA	NA	Belongs to the neurexin family.	NA	PE1	9
+NX_Q9BZ81	Melanoma-associated antigen B5	275	31906	7.56	0	NA	NA	NA	NA	NA	NA	PE2	X
+NX_Q9BZ95	Histone-lysine N-methyltransferase NSD3	1437	161613	8.57	0	Nucleoplasm;Mitochondrion;Nucleus;Chromosome	NA	Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	Lysine degradation;PKMTs methylate histone lysines	PE1	8
+NX_Q9BZ97	Putative transcript Y 13 protein	58	6256	4.45	1	Membrane	NA	NA	NA	NA	NA	PE5	Y
+NX_Q9BZ98	Putative transcript Y 12 protein	90	10490	9.55	0	NA	NA	NA	NA	NA	NA	PE5	Y
+NX_Q9BZA0	Putative transcript Y 10 protein	68	7782	9.63	0	NA	NA	NA	NA	NA	NA	PE5	Y
+NX_Q9BZA5	Putative gamma-taxilin 2	131	14632	5.22	0	NA	NA	NA	NA	Belongs to the taxilin family.	NA	PE5	Y
+NX_Q9BZA7	Protocadherin-11 X-linked	1347	147558	5.04	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein.	NA	NA	NA	PE1	X
+NX_Q9BZA8	Protocadherin-11 Y-linked	1340	146775	5.03	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein.	NA	NA	NA	PE1	Y
+NX_Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1	566	62595	7.55	0	Cytoplasm;Membrane;Nucleoplasm;P-body;Postsynaptic density;Synapse;Dendrite;Cytosol;Cytoplasmic granule;Nucleus	NA	Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195).	Phosphorylated on serine/threonine residues by AURKA within positions 166 and 197. Phosphorylation and dephosphorylation on Thr-172 regulates cytoplasmic polyadenylation and translation of CPE-containing mRNAs. Phosphorylation on Thr-172 by AURKA and CAMK2A activates CPEB1. Phosphorylation on Thr-172 may be promoted by APLP1. Phosphorylation increases binding to RNA (By similarity).;CPEB1 is phosphorylated by AURKA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the RRM CPEB family.	Oocyte meiosis;Dorso-ventral axis formation;Progesterone-mediated oocyte maturation	PE1	15
+NX_Q9BZC1	CUGBP Elav-like family member 4	486	51966	8.11	0	Nucleoplasm;Cytoplasm;Nucleus	NA	RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.	NA	Belongs to the CELF/BRUNOL family.	NA	PE1	18
+NX_Q9BZC7	ATP-binding cassette sub-family A member 2	2435	269833	6.37	14	Lysosome membrane;Endosome membrane	NA	Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.	Methylated at Gln-271 by N6AMT1.	Belongs to the ABC transporter superfamily. ABCA family.	ABC transporters;Lysosome;ABC transporters in lipid homeostasis	PE1	9
+NX_Q9BZD2	Equilibrative nucleoside transporter 3	475	51815	7.95	11	Golgi apparatus;Lysosome membrane;Membrane;Cytoplasmic vesicle;Late endosome membrane	Histiocytosis-lymphadenopathy plus syndrome	Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine.	NA	Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane;Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)	PE1	10
+NX_Q9BZD3	Putative GRINL1B complex locus protein 2	368	41713	6.36	0	NA	NA	NA	NA	Belongs to the GRINL1 family.	NA	PE5	4
+NX_Q9BZD4	Kinetochore protein Nuf2	464	54304	8.41	0	Nucleoplasm;Nucleus;Kinetochore	NA	Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).	Can be phosphorylated by AURKA and AURKB.	Belongs to the NUF2 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	1
+NX_Q9BZD6	Transmembrane gamma-carboxyglutamic acid protein 4	226	25403	7.08	1	Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment membrane	NA	May control axon guidance across the CNS (PubMed:28859078). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (PubMed:28859078).	Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.	Belongs to the commissureless family.	NA	PE1	11
+NX_Q9BZD7	Transmembrane gamma-carboxyglutamic acid protein 3	231	25875	5.75	1	Membrane	NA	NA	Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.	NA	NA	PE2	X
+NX_Q9BZE0	Zinc finger protein GLIS2	524	55689	9.08	0	Cytoplasm;Nucleus speckle;Cell membrane;Nucleoplasm;Cytosol	Nephronophthisis 7	Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity).	C-terminus cleavage is induced by interaction with CTNND1 and enhanced by Src tyrosine kinase.	Belongs to the GLI C2H2-type zinc-finger protein family.	NA	PE1	16
+NX_Q9BZE1	39S ribosomal protein L37, mitochondrial	423	48117	8.83	0	Cytoplasm;Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL37 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	1
+NX_Q9BZE2	tRNA pseudouridine(38/39) synthase	481	55647	7.2	0	Nucleoplasm;Cytosol;Nucleus	Mental retardation, autosomal recessive 55	Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs.	NA	Belongs to the tRNA pseudouridine synthase TruA family.	tRNA modification in the nucleus and cytosol	PE1	11
+NX_Q9BZE3	BarH-like 1 homeobox protein	327	35074	9.05	0	Nucleus	NA	NA	NA	Belongs to the BAR homeobox family.	NA	PE1	9
+NX_Q9BZE4	Nucleolar GTP-binding protein 1	634	73964	9.52	0	Nucleus membrane;Nucleolus	NA	Involved in the biogenesis of the 60S ribosomal subunit.	NA	Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	Ribosome biogenesis in eukaryotes	PE1	10
+NX_Q9BZE7	UPF0193 protein EVG1	217	24956	9.83	0	Nucleoplasm	NA	NA	NA	Belongs to the UPF0193 (EVG1) family.	NA	PE1	22
+NX_Q9BZE9	Tether containing UBX domain for GLUT4	553	60183	6.23	0	Endoplasmic reticulum-Golgi intermediate compartment membrane;Cytoplasm;Cell membrane;Endomembrane system;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.	NA	NA	Translocation of SLC2A4 (GLUT4) to the plasma membrane	PE1	17
+NX_Q9BZF1	Oxysterol-binding protein-related protein 8	889	101196	6.52	1	Endoplasmic reticulum membrane;Cell membrane;Nucleus membrane;Cytoplasmic vesicle;Cytosol	NA	Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267).	NA	Belongs to the OSBP family.	Acyl chain remodelling of PS	PE1	12
+NX_Q9BZF2	Oxysterol-binding protein-related protein 7	842	95432	8.31	0	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane;Cell membrane	NA	NA	NA	Belongs to the OSBP family.	Synthesis of bile acids and bile salts	PE1	17
+NX_Q9BZF3	Oxysterol-binding protein-related protein 6	934	106306	6.48	0	Endoplasmic reticulum membrane;Cytosol;Nucleus envelope;Cell membrane	NA	Weakly binds 25-hydroxycholesterol.	NA	Belongs to the OSBP family.	Synthesis of bile acids and bile salts	PE1	2
+NX_Q9BZF9	Uveal autoantigen with coiled-coil domains and ankyrin repeats	1416	162505	6.6	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity).;Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).	NA	NA	Regulation of the apoptosome activity	PE1	15
+NX_Q9BZG1	Ras-related protein Rab-34	259	29044	8.07	0	Golgi apparatus;Cytoplasm;Phagosome membrane;Cilium;Phagosome	NA	Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity).	NA	Belongs to the small GTPase superfamily. Rab family.	RAB geranylgeranylation	PE1	17
+NX_Q9BZG2	Testicular acid phosphatase	426	46090	8.45	1	Membrane	Amelogenesis imperfecta 1J	May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage (PubMed:15219672). May play a role in odontogenesis (PubMed:27843125).	Glycosylated.	Belongs to the histidine acid phosphatase family.	Riboflavin metabolism	PE1	19
+NX_Q9BZG8	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1	443	48805	8.47	0	Cytoplasm;Nucleoplasm;Cell junction;Nucleus	Developmental delay with short stature, dysmorphic features, and sparse hair	Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity).	NA	Belongs to the DPH1/DPH2 family. DPH1 subfamily.	Protein modification; peptidyl-diphthamide biosynthesis.;Synthesis of diphthamide-EEF2	PE1	17
+NX_Q9BZH6	WD repeat-containing protein 11	1224	136685	6.48	0	trans-Golgi network;Cytoplasm;Cilium basal body;Cilium axoneme;Cytoplasmic vesicle;Cytosol;Nucleus;Cytoskeleton	Hypogonadotropic hypogonadism 14 with or without anosmia	Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865).	NA	NA	NA	PE1	10
+NX_Q9BZI1	Iroquois-class homeodomain protein IRX-2	471	49129	5.14	0	Nucleoplasm;Nucleolus;Nucleus	NA	NA	NA	Belongs to the TALE/IRO homeobox family.	NA	PE1	5
+NX_Q9BZI7	Regulator of nonsense transcripts 3B	483	57762	9.48	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	Mental retardation, X-linked, syndromic, 14	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.	NA	Belongs to the RENT3 family.	RNA transport;mRNA surveillance pathway;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Regulation of expression of SLITs and ROBOs;RNA Polymerase II Transcription Termination	PE1	X
+NX_Q9BZJ0	Crooked neck-like protein 1	848	100452	8.1	0	Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing process.	NA	Belongs to the crooked-neck family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	20
+NX_Q9BZJ3	Tryptase delta	242	26584	5.51	0	Nucleus speckle;Secreted	NA	Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.	NA	Belongs to the peptidase S1 family. Tryptase subfamily.	NA	PE1	16
+NX_Q9BZJ4	Solute carrier family 25 member 39	359	39249	9.68	6	Mitochondrion inner membrane;Mitochondrion	NA	Required for normal heme biosynthesis.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	17
+NX_Q9BZJ6	Probable G-protein coupled receptor 63	419	47578	9.6	7	Nucleoplasm;Cytosol;Cell membrane	NA	Orphan receptor. May play a role in brain function.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	6
+NX_Q9BZJ7	G-protein coupled receptor 62	368	37614	10.86	7	Cell membrane;Endosome membrane	NA	Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	3
+NX_Q9BZJ8	G-protein coupled receptor 61	451	49292	6.19	7	Cell membrane;Endosome membrane	NA	Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	1
+NX_Q9BZK3	Putative nascent polypeptide-associated complex subunit alpha-like protein	213	23306	4.53	0	NA	NA	NA	NA	Belongs to the NAC-alpha family.	NA	PE5	8
+NX_Q9BZK7	F-box-like/WD repeat-containing protein TBL1XR1	514	55595	5.28	0	Nucleoplasm;Nucleus	Pierpont syndrome;Mental retardation, autosomal dominant 41	F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.	NA	Belongs to the WD repeat EBI family.	Wnt signaling pathway;PPARA activates gene expression;HDACs deacetylate histones;Notch-HLH transcription pathway;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Regulation of MECP2 expression and activity;Loss of MECP2 binding ability to the NCoR/SMRT complex	PE1	3
+NX_Q9BZK8	Ovarian cancer-related protein 1	76	8369	8.97	0	NA	NA	NA	NA	NA	NA	PE4	1
+NX_Q9BZL1	Ubiquitin-like protein 5	73	8547	8.58	0	Cytoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q9BZL3	Small integral membrane protein 3	60	6593	6.69	1	Membrane;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	5
+NX_Q9BZL4	Protein phosphatase 1 regulatory subunit 12C	782	84881	5.44	0	Cytoplasm;Stress fiber	NA	Regulates myosin phosphatase activity.	Phosphorylation at Thr-560 is essential for its interaction with PPP1CB.	NA	NA	PE1	19
+NX_Q9BZL6	Serine/threonine-protein kinase D2	878	96722	6.39	0	trans-Golgi network;Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467).	Phosphorylation of Ser-876 correlates with the activation status of the kinase (PubMed:11062248). Ser-706 or/and Ser-710 are probably phosphorylated by PKC (PubMed:12058027, PubMed:28428613). Phosphorylation at Ser-244 by CSNK1D and CSNK1E promotes nuclear localization and substrate targeting (PubMed:17962809). Phosphorylation at Ser-244, Ser-706 and Ser-710 is required for nuclear localization (PubMed:17962809). Phosphorylated at Tyr-438 by ABL1 in response to oxidative stress (PubMed:15604256). Phosphorylated at Tyr-717 by ABL1 specifically in response to oxidative stress; requires prior phosphorylation at Ser-706 or/and Ser-710 (PubMed:28428613).;PRKD2 is phosphorylated by SRC (Phosphotyrosine:PTM-0255);PRKD2 is phosphorylated by LCK (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.	Sphingolipid de novo biosynthesis	PE1	19
+NX_Q9BZM1	Group XIIA secretory phospholipase A2	189	21067	6.95	0	Cytoplasm;Secreted	NA	PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.	NA	Belongs to the phospholipase A2 family.	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI	PE1	4
+NX_Q9BZM2	Group IIF secretory phospholipase A2	168	18658	5.09	0	Secreted;Cell membrane	NA	May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity). Phospholipase A2, which catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:11112443). Hydrolyzes phosphatidylethanolamine more efficiently than phosphatidylcholine, with only a modest preference for arachidonic acid versus linoelic acid at the sn-2 position. Comparable activity toward 1-palmitoyl-2-oleoyl-phosphatidylserine vesicles to that toward 1-palmitoyl-2-oleoyl-phosphatidylglycerol (By similarity). Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference (PubMed:11112443).	NA	Belongs to the phospholipase A2 family.	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI	PE1	1
+NX_Q9BZM3	GS homeobox 2	304	32031	9.22	0	Nucleus	NA	During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Transcription factor that binds 5'-CNAATTAG-3' DNA sequence.	NA	Belongs to the Antp homeobox family.	NA	PE2	4
+NX_Q9BZM4	UL16-binding protein 3	244	27949	8.2	0	Cytoplasmic vesicle;Centriolar satellite;Cell membrane	NA	Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.	NA	Belongs to the MHC class I family.	Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	6
+NX_Q9BZM5	UL16-binding protein 2	246	27368	6.93	0	Cytoplasmic vesicle;Endoplasmic reticulum;Secreted;Cell membrane	NA	Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.	NA	Belongs to the MHC class I family.	Natural killer cell mediated cytotoxicity;Post-translational modification: synthesis of GPI-anchored proteins	PE1	6
+NX_Q9BZM6	UL16-binding protein 1	244	27997	7.07	0	Endoplasmic reticulum;Cytosol;Cell membrane	NA	Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.	NA	Belongs to the MHC class I family.	Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	6
+NX_Q9BZP3	Putative uncharacterized protein encoded by LINC00470	86	9646	4.99	0	NA	NA	NA	NA	NA	NA	PE5	18
+NX_Q9BZP6	Acidic mammalian chitinase	476	52271	5.54	0	Cytoplasm;Secreted	NA	Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.	NA	Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.	Amino sugar and nucleotide sugar metabolism;Digestion of dietary carbohydrate	PE1	1
+NX_Q9BZQ2	Testicular spindle-associated protein SHCBP1L	653	72632	5.2	0	Spindle	NA	Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells.	NA	NA	NA	PE1	1
+NX_Q9BZQ4	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2	307	34439	6.59	0	Cytoplasm;Axon;Cytoplasmic vesicle membrane;Golgi apparatus membrane	NA	Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747). Also catalyzes the reverse reaction, i.e. The pyrophosphorolytic cleavage of NAD(+) (PubMed:16118205, PubMed:17402747). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed:16118205, PubMed:17402747). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:16118205, PubMed:17402747). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity).	Degraded in response to injured neurite. Degradation is probably caused by ubiquitination by MYCBP2 (By similarity). Ubiquitinated on threonine and/or serine residues by MYCBP2; consequences of threonine and/or serine ubiquitination are however unclear (PubMed:29643511).;Palmitoylated; palmitoylation is required for membrane association.	Belongs to the eukaryotic NMN adenylyltransferase family.	Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.;Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.;Nicotinate and nicotinamide metabolism;Metabolic pathways;Nicotinate metabolism	PE1	1
+NX_Q9BZQ6	ER degradation-enhancing alpha-mannosidase-like protein 3	932	104664	4.82	0	Endoplasmic reticulum;Endoplasmic reticulum lumen	NA	Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity).	NA	Belongs to the glycosyl hydrolase 47 family.	Protein modification; protein glycosylation.;Protein processing in endoplasmic reticulum;ER Quality Control Compartment (ERQC)	PE1	1
+NX_Q9BZQ8	Protein Niban 1	928	103135	4.74	0	Membrane;Cytoplasm;Cytosol;Cell membrane	NA	Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity).	NA	Belongs to the Niban family.	NA	PE1	1
+NX_Q9BZR6	Reticulon-4 receptor	473	50708	9.22	0	Cell membrane;Perikaryon;Focal adhesion;Endoplasmic reticulum;Membrane raft;Axon;Dendrite;Cytoskeleton	Schizophrenia	Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).	N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.	Belongs to the Nogo receptor family.	Axonal growth inhibition (RHOA activation)	PE1	22
+NX_Q9BZR8	Apoptosis facilitator Bcl-2-like protein 14	327	36598	6.17	0	Cytoplasm;Endomembrane system;Cytosol	NA	Plays a role in apoptosis.	Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.;BCL2L14 is phosphorylated by MELK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the Bcl-2 family.	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	PE1	12
+NX_Q9BZR9	E3 ubiquitin-protein ligase TRIM8	551	61489	7.26	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase which plays different roles in immune pathways. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'lys-63' polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791). Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148).	NA	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Interferon gamma signaling	PE1	10
+NX_Q9BZS1	Forkhead box protein P3	431	47244	9.52	0	Cytoplasm;Nucleoplasm;Nucleus	Immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome	Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).	Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1.;Phosphorylation at Ser-418 regulates its transcriptional repressor activity and consequently, regulatory T-cells (Treg) suppressive function. Dephosphorylated at Ser-418 by protein phosphatase 1 (PP1) in Treg cells derived from patients with rheumatoid arthritis. Phosphorylation by CDK2 negatively regulates its transcriptional activity and protein stability (By similarity).;Undergoes proteolytic cleavage in activated regulatory T-cells (Treg), and can be cleaved at either the N- or C-terminal site, or at both sites.;Polyubiquitinated, leading to its proteasomal degradation in regulatory T-cells (Treg) which is mediated by STUB1 in a HSPA1A/B-dependent manner. Deubiquitinated by USP7 leading to increase in protein stability.	NA	RUNX1 regulates transcription of genes involved in WNT signaling;RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	PE1	X
+NX_Q9BZS9	Putative uncharacterized protein PNAS-138	49	5619	5.91	0	NA	NA	NA	NA	NA	NA	PE5	7
+NX_Q9BZV1	UBX domain-containing protein 6	441	49754	6.46	0	Cytoplasm;Golgi apparatus;Lysosome membrane;Late endosome membrane;Membrane;Centrosome;Early endosome membrane;Cytosol;Nucleus	NA	May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622).	NA	NA	Protein processing in endoplasmic reticulum	PE1	19
+NX_Q9BZV2	Thiamine transporter 2	496	55665	6.01	12	Membrane;Nucleoplasm;Cytosol;Cell membrane	Thiamine metabolism dysfunction syndrome 2, biotin- or thiamine-responsive type	Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.	NA	Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.	Vitamin digestion and absorption;Vitamin B1 (thiamin) metabolism	PE1	2
+NX_Q9BZV3	Interphotoreceptor matrix proteoglycan 2	1241	138621	4.52	1	Photoreceptor inner segment membrane;Interphotoreceptor matrix;Photoreceptor outer segment membrane	Macular dystrophy, vitelliform, 5;Retinitis pigmentosa 56	Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin.	Highly glycosylated (N- and O-linked carbohydrates).	NA	NA	PE1	3
+NX_Q9BZW2	Solute carrier family 13 member 1	595	66134	8.35	13	Membrane	NA	Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.	NA	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.	Sodium-coupled sulphate, di- and tri-carboxylate transporters	PE1	7
+NX_Q9BZW4	Transmembrane 6 superfamily member 2	377	42554	7.95	9	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane	NA	Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content (PubMed:24531328, PubMed:24927523). May function as sterol isomerase (PubMed:25566323).	NA	Belongs to the TM6SF family.	NA	PE1	19
+NX_Q9BZW5	Transmembrane 6 superfamily member 1	370	41636	7.55	9	Lysosome membrane	NA	May function as sterol isomerase.	NA	Belongs to the TM6SF family.	NA	PE1	15
+NX_Q9BZW7	Testis-specific gene 10 protein	698	81421	5.73	0	Cytoplasm;Cytosol;Centriole	Spermatogenic failure 26	Plays a role in spermatogenesis (PubMed:28905369). When overexpressed, prevents nuclear localization of HIF1A (By similarity).	Processed into N-terminal 27-kDa and C-terminal 55-kDa fragments.	Belongs to the CEP135/TSGA10 family.	NA	PE1	2
+NX_Q9BZW8	Natural killer cell receptor 2B4	370	41616	9.14	1	Membrane;Cell membrane	NA	Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity).	Phosphorylated by FYN and CSK on tyrosine residues following activation. Coligation with inhibitory receptors such as KIR2DL1 inhibits phosphorylation upon contact of NK cells with sensitive target cells.;N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding.	NA	Natural killer cell mediated cytotoxicity;Cell surface interactions at the vascular wall	PE1	1
+NX_Q9BZX2	Uridine-cytidine kinase 2	261	29299	6.24	0	Nucleoplasm	NA	Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.	UCK2 is phosphorylated by PASK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the uridine kinase family.	Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.;Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.;Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine salvage	PE1	1
+NX_Q9BZX4	Ropporin-1B	212	23964	5.11	0	Flagellum	NA	Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.	Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.	Belongs to the ropporin family.	NA	PE1	3
+NX_Q9BZY9	E3 ubiquitin-protein ligase TRIM31	425	48244	7.55	0	Cytoplasm;Mitochondrion	NA	Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.	Auto-ubiquitinated (in vitro).	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Interferon gamma signaling	PE1	6
+NX_Q9BZZ2	Sialoadhesin	1709	182624	6.15	1	Secreted;Cell membrane	NA	Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.	NA	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Cell adhesion molecules (CAMs);Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	20
+NX_Q9BZZ5	Apoptosis inhibitor 5	524	59005	6.99	0	Cytoplasm;Nucleus speckle;Nucleus	NA	Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.	Acetylation at Lys-251 impairs antiapoptotic function.	Belongs to the API5 family.	NA	PE1	11
+NX_Q9C000	NACHT, LRR and PYD domains-containing protein 1	1473	165866	6.39	0	Cytoplasm;Inflammasome;Nucleoplasm;Cytosol;Nucleus	Palmoplantar carcinoma, multiple self-healing;Vitiligo-associated multiple autoimmune disease 1;Autoinflammation with arthritis and dyskeratosis	As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).	NA	Belongs to the NLRP family.	NOD-like receptor signaling pathway;The NLRP1 inflammasome	PE1	17
+NX_Q9C002	Normal mucosa of esophagus-specific gene 1 protein	83	9617	9.45	0	Nucleus	NA	NA	NA	Belongs to the complex I NDUFA4 subunit family.	NA	PE1	15
+NX_Q9C004	Protein sprouty homolog 4	299	32541	8.25	0	Ruffle membrane;Cytoplasm	Hypogonadotropic hypogonadism 17 with or without anosmia	Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.	NA	Belongs to the sprouty family.	Jak-STAT signaling pathway	PE1	5
+NX_Q9C005	Protein dpy-30 homolog	99	11250	4.84	0	trans-Golgi network;Nucleoplasm;Golgi apparatus;Nucleus	NA	As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.	NA	Belongs to the dpy-30 family.	PKMTs methylate histone lysines;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	2
+NX_Q9C009	Forkhead box protein Q1	403	41526	9.52	0	Nucleoplasm;Nucleus	NA	Plays a role in hair follicle differentiation.	NA	NA	NA	PE1	6
+NX_Q9C010	cAMP-dependent protein kinase inhibitor beta	78	8468	4.76	0	NA	NA	Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.	NA	Belongs to the PKI family.	NA	PE1	6
+NX_Q9C019	Tripartite motif-containing protein 15	465	52113	5.4	0	Cytosol;Centriolar satellite	NA	NA	NA	Belongs to the TRIM/RBCC family.	NA	PE1	6
+NX_Q9C026	E3 ubiquitin-protein ligase TRIM9	710	79177	6.4	0	Cytoplasm;Synapse;Dendrite;Synaptic vesicle;Cytoskeleton	NA	E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.	Auto-ubiquitinated. Poly-ubiquitinated in cultured cells, whereas it is monoubiquitinated in vitro.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	14
+NX_Q9C029	E3 ubiquitin-protein ligase TRIM7	511	56631	7.81	0	Cytoplasmic vesicle;Nucleoplasm;Cytosol	NA	E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation.	Phosphorylated at Ser-107 by RPS6KA5/MSK1, which stimulates the ubiquitin ligase activity.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.	PE1	5
+NX_Q9C030	Tripartite motif-containing protein 6	488	56400	7.5	0	Cytoplasm	NA	E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response (PubMed:24882218).	NA	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Interferon gamma signaling	PE1	11
+NX_Q9C035	Tripartite motif-containing protein 5	493	56338	5.73	0	Cytoplasm;Cytosol;Nucleus	NA	Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).	Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus.;Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Interferon gamma signaling	PE1	11
+NX_Q9C037	E3 ubiquitin-protein ligase TRIM4	500	57461	8.4	0	Cytoplasm;Cytosol;Cell membrane	NA	E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction.	NA	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	7
+NX_Q9C040	Tripartite motif-containing protein 2	744	81530	6.51	0	Cytoplasm;Centrosome	Charcot-Marie-Tooth disease 2R	UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.	RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Interferon gamma signaling	PE1	4
+NX_Q9C056	Homeobox protein Nkx-6.2	277	29263	9.71	0	Nucleus	Spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy	Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions.	NA	NA	NA	PE1	10
+NX_Q9C073	Protein FAM117A	453	48319	8.67	0	Nucleoplasm	NA	NA	NA	Belongs to the FAM117 family.	NA	PE1	17
+NX_Q9C075	Keratin, type I cytoskeletal 23	422	48131	6.09	0	Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	17
+NX_Q9C086	INO80 complex subunit B	356	38637	9.66	0	Nucleoplasm;Nucleus;Nucleolus	NA	Induces growth and cell cycle arrests at the G1 phase of the cell cycle.;Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.	NA	NA	DNA Damage Recognition in GG-NER;UCH proteinases	PE1	2
+NX_Q9C091	GREB1-like protein	1923	214354	6.18	1	Membrane;Cytosol	Renal hypodysplasia/aplasia 3	Plays a major role in early metanephros and genital development.	NA	Belongs to the GREB1 family.	NA	PE1	18
+NX_Q9C093	Sperm flagellar protein 2	1822	209811	5.4	0	Golgi apparatus;Cytoplasm	NA	Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation.	NA	NA	NA	PE1	5
+NX_Q9C098	Serine/threonine-protein kinase DCLK3	648	73814	9	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	NA	PE1	3
+NX_Q9C099	Leucine-rich repeat and coiled-coil domain-containing protein 1	1032	119596	5.62	0	Centrosome;Centriole	NA	Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.	NA	Belongs to the LRRCC1 family.	NA	PE1	8
+NX_Q9C0A0	Contactin-associated protein-like 4	1308	145274	6.22	1	Presynaptic cell membrane	NA	Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity).	NA	Belongs to the neurexin family.	NA	PE1	16
+NX_Q9C0A1	Zinc finger homeobox protein 2	2572	274176	5.59	0	Nucleoplasm;Nucleus;Nucleolus	Marsili syndrome	Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli.	NA	NA	NA	PE1	14
+NX_Q9C0A6	Histone-lysine N-methyltransferase SETD5	1442	157515	8.74	0	Nucleoplasm;Cytosol;Nucleus	Mental retardation, autosomal dominant 23	Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 in vitro. The physiological significance of this activity is unclear. Probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Acts as a regulator of histone acetylation during gene transcription.	NA	NA	NA	PE1	3
+NX_Q9C0B0	RING finger protein unkempt homolog	810	88084	6.4	0	Cytoplasm;Cytosol	NA	Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).	NA	Belongs to the unkempt family.	NA	PE1	17
+NX_Q9C0B1	Alpha-ketoglutarate-dependent dioxygenase FTO	505	58282	5.1	0	Cytoplasm;Nucleus speckle;Cytoplasmic vesicle;Cytosol;Nucleus	Growth retardation, developmental delay, and facial dysmorphism;Obesity	RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:26458103, PubMed:28002401, PubMed:30197295, PubMed:26457839, PubMed:25452335). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103, PubMed:30197295, PubMed:26457839, PubMed:25452335). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359).	NA	Belongs to the fto family.	Reversal of alkylation damage by DNA dioxygenases	PE1	16
+NX_Q9C0B2	Cilia- and flagella-associated protein 74	1584	178589	6.01	0	Cilium axoneme	NA	As part of the central apparatus of the cilium axoneme may play a role in cilium movement.	NA	Belongs to the CFAP74 family.	NA	PE1	1
+NX_Q9C0B5	Palmitoyltransferase ZDHHC5	715	77545	9.17	4	Nucleoplasm;Cell junction;Cell membrane	NA	Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).	NA	Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.	NA	PE1	11
+NX_Q9C0B6	BMP/retinoic acid-inducible neural-specific protein 2	783	89005	8.18	0	Secreted	NA	Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.	NA	Belongs to the BRINP family.	NA	PE1	1
+NX_Q9C0B7	Transport and Golgi organization protein 6 homolog	1094	120748	5.75	1	Membrane;Golgi apparatus;Cytosol	NA	NA	NA	Belongs to the Tango6 family.	NA	PE1	16
+NX_Q9C0B9	Zinc finger CCHC domain-containing protein 2	1178	125936	6.55	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	18
+NX_Q9C0C2	182 kDa tankyrase-1-binding protein	1729	181796	4.77	0	Chromosome;Nucleus;Cytoskeleton	NA	NA	ADP-ribosylated by TNKS1 (in vitro).	NA	Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	11
+NX_Q9C0C4	Semaphorin-4C	833	92623	6.92	1	Synaptic vesicle membrane;Postsynaptic density membrane	NA	Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.	NA	Belongs to the semaphorin family.	Axon guidance	PE1	2
+NX_Q9C0C6	CLOCK-interacting pacemaker	399	42692	9.08	0	Cytosol;Nucleus	NA	Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.	NA	NA	NA	PE1	14
+NX_Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	1298	142507	6.73	0	Cytoplasmic vesicle;Autophagosome;Mitochondrion	NA	Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).	NA	NA	Macroautophagy	PE1	11
+NX_Q9C0C9	(E3-independent) E2 ubiquitin-conjugating enzyme	1292	141293	5.01	0	Nucleoplasm;Cytoplasm;Nucleus	NA	E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).	Ubiquitinated: autoubiquitinates, possibly affecting its subcellular location.;Phosphorylated. Phosphorylation affects subcellular location.	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	17
+NX_Q9C0D0	Phosphatase and actin regulator 1	580	66308	6.51	0	Cytoplasm;Nucleus;Synapse;Cell membrane	Epileptic encephalopathy, early infantile, 70	Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity).	NA	Belongs to the phosphatase and actin regulator family.	NA	PE1	6
+NX_Q9C0D2	Centrosomal protein of 295 kDa	2601	295176	5.68	0	Cell membrane;Centriole;Centrosome;Cytosol;Spindle;Cytoskeleton	NA	Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865). Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865).	NA	NA	NA	PE1	11
+NX_Q9C0D3	Protein zyg-11 homolog B	744	83921	6.38	0	Golgi apparatus;Cytoskeleton	NA	Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098).	NA	Belongs to the zyg-11 family.	NA	PE1	1
+NX_Q9C0D4	Zinc finger protein 518B	1074	119531	9.52	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	4
+NX_Q9C0D5	Protein TANC1	1861	202219	8.63	0	Postsynaptic density	NA	May be a scaffold component in the postsynaptic density.	Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.;TANC1 is phosphorylated by TNIK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);TANC1 is phosphorylated by MINK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the TANC family.	NA	PE1	2
+NX_Q9C0D6	FH2 domain-containing protein 1	1143	124762	9.17	0	Golgi apparatus;Cilium	NA	Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020).	NA	NA	NA	PE1	4
+NX_Q9C0D7	Probable ribonuclease ZC3H12C	883	99340	6.48	0	Golgi apparatus;Nucleus membrane	NA	May function as RNase and regulate the levels of target RNA species.	NA	Belongs to the ZC3H12 family.	NA	PE1	11
+NX_Q9C0D9	Ethanolaminephosphotransferase 1	397	45229	6.12	10	Membrane	NA	Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway.	NA	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.;Glycerophospholipid metabolism;Ether lipid metabolism;Metabolic pathways;Synthesis of PE	PE1	2
+NX_Q9C0E2	Exportin-4	1151	130139	4.95	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.	NA	Belongs to the exportin family.	NA	PE1	13
+NX_Q9C0E4	Glutamate receptor-interacting protein 2	1043	112573	6.02	0	Membrane;Cytoplasm;Cytosol	NA	May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.	NA	Belongs to the GRIP2 family.	Trafficking of GluR2-containing AMPA receptors	PE1	3
+NX_Q9C0E8	Endoplasmic reticulum junction formation protein lunapark	428	47740	5.07	2	Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum membrane	Neurodevelopmental disorder with epilepsy and hypoplasia of the corpus callosum	Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983).	Subject to proteasomal degradation following phosphorylation during mitosis (PubMed:27619977).;Phosphorylated. Phosphorylation occurs at Ser-177, Ser-182, Ser-217, Ser-227, Ser-321 and Ser-384 during interphase (PubMed:27619977). Phosphorylation occurs at Ser-114, Ser-153, Ser-194, Thr-211 and Ser-353 during mitosis; these phosphorylations reduce both its homodimerization and the ER three-way tubular junction formation (PubMed:27619977).;Myristoylated; myristoylation is necessary for the endoplasmic reticulum (ER) three-way ER tubular junction formation, but is not required neither for membrane translocation, membrane topology formation, nor for the specific localization to ER membranes (PubMed:24223779).	Belongs to the lunapark family.	NA	PE1	2
+NX_Q9C0F0	Putative Polycomb group protein ASXL3	2248	241919	5.8	0	Nucleus	Bainbridge-Ropers syndrome	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity).	NA	Belongs to the Asx family.	NA	PE1	18
+NX_Q9C0F1	Centrosomal protein of 44 kDa	390	44140	5.13	0	Spindle pole;Centrosome;Midbody	NA	NA	NA	NA	NA	PE1	4
+NX_Q9C0F3	Zinc finger protein 436	470	54277	6.75	0	Nucleoplasm;Cytosol;Nucleus	NA	May be a transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q9C0G0	Zinc finger protein 407	2248	247367	6.05	0	Nucleoplasm;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	18
+NX_Q9C0G6	Dynein heavy chain 6, axonemal	4158	475983	5.72	0	Cilium axoneme	NA	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).	NA	Belongs to the dynein heavy chain family.	NA	PE1	2
+NX_Q9C0H2	Protein tweety homolog 3	523	57545	5.19	5	Cell membrane	NA	Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction.	N-glycosylated.	Belongs to the tweety family.	Stimuli-sensing channels	PE1	7
+NX_Q9C0H5	Rho GTPase-activating protein 39	1083	121286	7.3	0	Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	NA	NA	NA	Rho GTPase cycle;Inactivation of CDC42 and RAC1	PE1	8
+NX_Q9C0H6	Kelch-like protein 4	718	80245	6.39	0	Centriolar satellite;Cytoskeleton	NA	NA	NA	NA	NA	PE1	X
+NX_Q9C0H9	SRC kinase signaling inhibitor 1	1183	127105	9.39	0	Cytoplasm;Cell junction;Postsynapse;Presynapse;Postsynaptic density;Axon;Dendrite;Cytoskeleton	NA	Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.	Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.	Belongs to the SRCIN1 family.	NA	PE1	17
+NX_Q9C0I1	Myotubularin-related protein 12	747	86148	6.17	0	Sarcoplasmic reticulum;Cytoplasm;Sarcomere	NA	Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Synthesis of PIPs at the early endosome membrane	PE1	5
+NX_Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	900	99510	7.88	0	NA	NA	NA	NA	Belongs to the CCSER family.	NA	PE1	4
+NX_Q9C0I4	Thrombospondin type-1 domain-containing protein 7B	1608	179402	7.93	1	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	2
+NX_Q9C0I9	Leucine-rich repeat-containing protein 27	530	60089	9.62	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	NA	NA	PE2	10
+NX_Q9C0J1	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4	378	42310	9.44	1	Mitochondrion;Nucleolus;Golgi apparatus membrane	NA	Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides.	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;O-linked glycosylation of mucins;Keratan sulfate biosynthesis	PE1	12
+NX_Q9C0J8	pre-mRNA 3' end processing protein WDR33	1336	145891	9.24	0	Nucleoplasm;Nucleolus;Nucleus	NA	Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.	NA	Belongs to the WD repeat WDR33 family.	Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	2
+NX_Q9C0J9	Class E basic helix-loop-helix protein 41	482	50498	6.95	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity).	NA	NA	Circadian rhythm - mammal;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Circadian Clock	PE1	12
+NX_Q9C0K0	B-cell lymphoma/leukemia 11B	894	95519	6.1	0	Nucleoplasm;Nucleolus;Nucleus	Immunodeficiency 49;Intellectual developmental disorder with speech delay, dysmorphic facies, and T-cell abnormalities	Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity).	Sumoylated with SUMO1.	NA	NA	PE1	14
+NX_Q9C0K1	Zinc transporter ZIP8	460	49631	5.71	8	Membrane	Congenital disorder of glycosylation 2N	Acts as a manganese and zinc influx transporter (PubMed:12504855, PubMed:26637978). Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain (PubMed:26637978).	NA	Belongs to the ZIP transporter (TC 2.A.5) family.	Zinc influx into cells by the SLC39 gene family	PE1	4
+NX_Q9C0K3	Actin-related protein 3C	210	23712	5.36	0	NA	NA	May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.	NA	Belongs to the actin family.	NA	PE2	7
+NX_Q9C0K7	STE20-related kinase adapter protein beta	418	47026	6.52	0	Cytoplasm;Cytosol;Nucleus	NA	Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	Energy dependent regulation of mTOR by LKB1-AMPK	PE1	2
+NX_Q9GIP4	Putative L-type amino acid transporter 1-like protein IMAA	190	19840	6.72	3	Membrane	NA	NA	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.	NA	PE5	16
+NX_Q9GIY3	HLA class II histocompatibility antigen, DRB1-14 beta chain	266	30139	8.22	1	Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;Lysosome membrane;trans-Golgi network membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_Q9GZK3	Olfactory receptor 2B2	357	40412	8.61	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_Q9GZK4	Olfactory receptor 2H1	316	35339	9.02	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_Q9GZK6	Olfactory receptor 2J1	312	35454	8.31	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	6
+NX_Q9GZK7	Olfactory receptor 11A1	315	35250	8.05	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_Q9GZL7	Ribosome biogenesis protein WDR12	423	47708	5.57	0	Cell membrane;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	NA	Belongs to the WD repeat WDR12/YTM1 family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	2
+NX_Q9GZL8	Putative BPES syndrome breakpoint region protein	116	12676	4.52	0	NA	NA	NA	NA	NA	NA	PE2	3
+NX_Q9GZM3	DNA-directed RNA polymerase II subunit RPB11-b1	115	13088	6.28	0	Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).	NA	Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Huntington's disease;Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Huntington's disease	PE1	7
+NX_Q9GZM5	Protein YIPF3	350	38248	5.47	5	Golgi apparatus;Cytoplasm;Cell membrane;cis-Golgi network membrane;Nucleoplasm;Endoplasmic reticulum	NA	Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.	N-glycosylated in the ER (40 kDa form I), then O-glycosylated in the Golgi apparatus (46 kDa form II), the C-terminal lumenal region is later removed in the Golgi apparatus to produce a 36 kDa form III. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Thr-346: HexNAc (minor), HexHexNAc (major), Hex1HexNAc2 (minor), Hex2HexNAc2 (minor) and dHex1Hex2HexNAc2 (minor).	Belongs to the YIP1 family.	NA	PE1	6
+NX_Q9GZM6	Olfactory receptor 8D2	311	34857	8.37	7	Cell membrane	NA	Odorant receptor (Potential). May be involved in taste perception.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9GZM7	Tubulointerstitial nephritis antigen-like	467	52387	6.54	0	Secreted	NA	May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).	Glycosylated.	Belongs to the peptidase C1 family.	NA	PE1	1
+NX_Q9GZM8	Nuclear distribution protein nudE-like 1	345	38375	5.16	0	Spindle;Centrosome;Kinetochore;Cytoskeleton	NA	Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).	Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE.;Palmitoylation at Cys-273 reduces affinity for dynein.	Belongs to the nudE family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	17
+NX_Q9GZN0	Probable G-protein coupled receptor 88	384	40246	9.8	7	Cytoplasm;Nucleus;Cell membrane	Chorea, childhood-onset, with psychomotor retardation	Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	1
+NX_Q9GZN1	Actin-related protein 6	396	45810	4.92	0	Cytosol;Cell membrane;Nucleus;Cytoskeleton	NA	NA	NA	Belongs to the actin family. ARP6 subfamily.	NA	PE1	12
+NX_Q9GZN2	Homeobox protein TGIF2	237	25878	7.77	0	Nucleoplasm;Centrosome;Nucleus	NA	Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.	The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.	Belongs to the TALE/TGIF homeobox family.	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity	PE1	20
+NX_Q9GZN4	Brain-specific serine protease 4	317	33732	7.55	0	Nucleoplasm;Secreted	NA	Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.	NA	Belongs to the peptidase S1 family.	NA	PE1	16
+NX_Q9GZN6	Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5	736	82200	8.59	12	Membrane;Golgi apparatus	NA	NA	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily.	NA	PE1	19
+NX_Q9GZN7	Protein rogdi homolog	287	32254	8.3	0	Cytoplasm;Perikaryon;Presynapse;Nucleus envelope;Axon;Dendrite;Synaptic vesicle;Nucleus	Kohlschuetter-Toenz syndrome	NA	NA	Belongs to the rogdi family.	NA	PE1	16
+NX_Q9GZN8	UPF0687 protein C20orf27	174	19291	6.34	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the UPF0687 family.	NA	PE1	20
+NX_Q9GZP0	Platelet-derived growth factor D	370	42848	8.28	0	Golgi apparatus;Cytoplasmic vesicle;Secreted	NA	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).	Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.	Belongs to the PDGF/VEGF growth factor family.	Focal adhesion;Gap junction;Regulation of actin cytoskeleton;Prostate cancer;Melanoma;Signaling by PDGF	PE1	11
+NX_Q9GZP1	Neurensin-2	204	21983	4.69	2	Golgi apparatus;Cell membrane;Membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	May play a role in maintenance and/or transport of vesicles.	NA	Belongs to the VMP family.	NA	PE1	20
+NX_Q9GZP4	PITH domain-containing protein 1	211	24178	5.47	0	NA	NA	NA	NA	Belongs to the PITHD1 family.	NA	PE1	1
+NX_Q9GZP7	Vomeronasal type-1 receptor 1	353	40021	9.46	7	Cytoplasmic vesicle;Nucleoplasm;Cell membrane	NA	Putative pheromone receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	19
+NX_Q9GZP8	Immortalization up-regulated protein	106	10897	9.73	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	NA	NA	NA	NA	PE1	19
+NX_Q9GZP9	Derlin-2	239	27567	6.73	4	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	(Microbial infection) In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses.;Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908).	NA	Belongs to the derlin family.	Protein processing in endoplasmic reticulum;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;ER Quality Control Compartment (ERQC);ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis	PE1	17
+NX_Q9GZQ3	COMM domain-containing protein 5	224	24670	6.52	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).	NA	NA	Neddylation	PE1	8
+NX_Q9GZQ4	Neuromedin-U receptor 2	415	47696	8.96	7	Cell membrane	NA	Receptor for the neuromedin-U and neuromedin-S neuropeptides.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	5
+NX_Q9GZQ6	Neuropeptide FF receptor 1	430	47819	9.54	7	Cell membrane	NA	Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Orexin and neuropeptides FF and QRFP bind to their respective receptors	PE2	10
+NX_Q9GZQ8	Microtubule-associated proteins 1A/1B light chain 3B	125	14688	8.89	0	Autophagosome membrane;Cytoplasm;Endomembrane system;Autophagosome;Nucleus;Cytoskeleton	NA	Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, paticipates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).	The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.;Phosphorylation at Thr-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE) (By similarity). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.;The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).	Belongs to the ATG8 family.	Macroautophagy;Pink/Parkin Mediated Mitophagy;TBC/RABGAPs;Receptor Mediated Mitophagy	PE1	16
+NX_Q9GZR1	Sentrin-specific protease 6	1112	126146	6.3	0	Nucleoplasm;Cytosol;Nucleus	NA	Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.	NA	Belongs to the peptidase C48 family.	Protein modification; protein sumoylation.	PE1	6
+NX_Q9GZR2	RNA exonuclease 4	422	46672	9.79	0	Nucleoplasm;Nucleolus;Nucleus	NA	NA	NA	Belongs to the REXO4 family.	NA	PE1	9
+NX_Q9GZR5	Elongation of very long chain fatty acids protein 4	314	36829	9.49	7	Endoplasmic reticulum membrane	Spinocerebellar ataxia 34;Ichthyosis, spastic quadriplegia, and mental retardation;Stargardt disease 3	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.	N-glycosylated.	Belongs to the ELO family. ELOVL4 subfamily.	Lipid metabolism; fatty acid biosynthesis.;Fatty acid elongation;Synthesis of very long-chain fatty acyl-CoAs	PE1	6
+NX_Q9GZR7	ATP-dependent RNA helicase DDX24	859	96332	9.14	0	Nucleolus;Nucleus;Cytosol	NA	ATP-dependent RNA helicase.	NA	Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.	NA	PE1	14
+NX_Q9GZS0	Dynein intermediate chain 2, axonemal	605	68821	4.68	0	Cilium axoneme	Ciliary dyskinesia, primary, 9	Part of the dynein complex of respiratory cilia.	NA	Belongs to the dynein intermediate chain family.	Huntington's disease	PE1	17
+NX_Q9GZS1	DNA-directed RNA polymerase I subunit RPA49	419	47260	9.1	0	Nucleoplasm;Nucleolus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity).	NA	Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;B-WICH complex positively regulates rRNA expression	PE1	9
+NX_Q9GZS3	WD repeat-containing protein 61	305	33581	5.16	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.	NA	NA	RNA degradation;Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;mRNA decay by 3' to 5' exoribonuclease;E3 ubiquitin ligases ubiquitinate target proteins	PE1	15
+NX_Q9GZS9	Carbohydrate sulfotransferase 5	411	46161	10.07	1	Golgi apparatus membrane	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location.	NA	Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.	Keratan sulfate biosynthesis	PE1	16
+NX_Q9GZT3	SRA stem-loop-interacting RNA-binding protein, mitochondrial	109	12349	10.26	0	Mitochondrion;Nucleus	NA	RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.	NA	NA	NA	PE1	14
+NX_Q9GZT4	Serine racemase	340	36566	6.11	0	Cytoplasmic vesicle	NA	Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.	S-nitrosylated, leading to decrease the enzyme activity.	Belongs to the serine/threonine dehydratase family.	Glycine, serine and threonine metabolism;Serine biosynthesis	PE1	17
+NX_Q9GZT5	Protein Wnt-10a	417	46444	9.38	0	Extracellular matrix;Secreted	Tooth agenesis, selective, 4;Odonto-onycho-dermal dysplasia;Schopf-Schulz-Passarge syndrome	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954). Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954). Required for normal hair follicle function (PubMed:28589954).	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors)	PE1	2
+NX_Q9GZT6	Coiled-coil domain-containing protein 90B, mitochondrial	254	29506	6.99	1	Mitochondrion membrane;Mitochondrion	NA	NA	NA	Belongs to the CCDC90 family.	NA	PE1	11
+NX_Q9GZT8	NIF3-like protein 1	377	41968	6.19	0	Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.	NA	Belongs to the GTP cyclohydrolase I type 2/NIF3 family.	NA	PE1	2
+NX_Q9GZT9	Egl nine homolog 1	426	46021	8.83	0	Cytoplasm;Nucleus	Erythrocytosis, familial, 3	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.	S-nitrosylation inhibits the enzyme activity up to 60% under aerobic conditions. Chelation of Fe(2+) has no effect on the S-nitrosylation. It is uncertain whether nitrosylation occurs on Cys-323 or Cys-326.	NA	Pathways in cancer;Renal cell carcinoma;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	PE1	1
+NX_Q9GZU0	Uncharacterized protein C6orf62	229	27083	9.05	0	Cytoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	6
+NX_Q9GZU1	Mucolipin-1	580	65022	6.9	6	Golgi apparatus;Cell membrane;Phagosome membrane;Lysosome membrane;Cytoplasmic vesicle membrane;Nucleoplasm;Phagocytic cup;Cytoplasmic vesicle;Late endosome membrane	Mucolipidosis 4	May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase.;Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:15336987, PubMed:14749347, PubMed:29019983). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:27787197, PubMed:25733853). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity).	Phosphorylation by PKA inhibits channel activity. Dephosphorylation increases activity.;Palmitoylated; involved in association with membranes.;Proteolytically cleaved probably involving multiple lysosomal proteases including cathepsin B; inhibits lysosomal channel activity (PubMed:16257972).	Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN1 sub-subfamily.	Lysosome;TRP channels;Transferrin endocytosis and recycling	PE1	19
+NX_Q9GZU2	Paternally-expressed gene 3 protein	1588	180827	5.31	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q9GZU3	Transmembrane protein 39B	492	56274	9.51	8	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the TMEM39 family.	NA	PE1	1
+NX_Q9GZU5	Nyctalopin	481	52000	9.1	0	Extracellular matrix	Night blindness, congenital stationary, 1A	NA	NA	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.	NA	PE1	X
+NX_Q9GZU7	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1	261	29203	5.62	0	Nucleoplasm;Nucleus	NA	Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.	NA	NA	NA	PE1	2
+NX_Q9GZU8	PSME3-interacting protein	254	28912	5.38	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus.	Phosphorylation by CK2 stabilizes the interaction with PSME3.	NA	NA	PE1	16
+NX_Q9GZV1	Ankyrin repeat domain-containing protein 2	360	39859	5.72	0	Nucleus;PML body;Cytoplasmic vesicle;Cytosol;I band	NA	Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.	Phosphorylation at Ser-99 by PKB/AKT2 in response to oxidative stress induces translocation to the nucleus and negatively regulates myoblast differentiation.	NA	NA	PE1	10
+NX_Q9GZV3	High affinity choline transporter 1	580	63204	5	13	Cell membrane;Cell junction;Membrane;Synapse;Nucleus;Cytoskeleton	Myasthenic syndrome, congenital, 20, presynaptic;Neuronopathy, distal hereditary motor, 7A	Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent.	Phosphorylated.	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Cholinergic synapse;Acetylcholine Neurotransmitter Release Cycle;Transport of bile salts and organic acids, metal ions and amine compounds;Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A);Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)	PE1	2
+NX_Q9GZV4	Eukaryotic translation initiation factor 5A-2	153	16793	5.38	0	Cytoplasm;Endoplasmic reticulum membrane;Nuclear pore complex;Cytoplasmic vesicle;Nucleus	NA	MRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).	EIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).	Belongs to the eIF-5A family.	Hypusine synthesis from eIF5A-lysine	PE1	3
+NX_Q9GZV5	WW domain-containing transcription regulator protein 1	400	44101	5.49	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.	Phosphorylated by LATS2 and STK3/MST2. Phosphorylation by LATS2 results in creation of 14-3-3 binding sites, retention in the cytoplasm, and functional inactivation. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export.	NA	Signaling by Hippo;YAP1- and WWTR1 (TAZ)-stimulated gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Physiological factors;RUNX3 regulates YAP1-mediated transcription;RUNX2 regulates osteoblast differentiation	PE1	3
+NX_Q9GZV7	Hyaluronan and proteoglycan link protein 2	340	37775	9.12	0	Extracellular matrix	NA	Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).	NA	Belongs to the HAPLN family.	NA	PE1	1
+NX_Q9GZV8	PR domain zinc finger protein 14	571	64062	6.65	0	Nucleoplasm;Nucleus	NA	Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	Transcriptional regulation of pluripotent stem cells	PE1	8
+NX_Q9GZV9	Fibroblast growth factor 23	251	27954	9.17	0	Secreted	Tumoral calcinosis, hyperphosphatemic, familial, 2;Hypophosphatemic rickets, autosomal dominant	Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.	O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23.;Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases.	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR1;Signaling by activated point mutants of FGFR3;FGFR4 ligand binding and activation;FGFR3c ligand binding and activation;FGFR1c ligand binding and activation;FGFR1c and Klotho ligand binding and activation;FGFR2c ligand binding and activation;FGFR3 mutant receptor activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;Phospholipase C-mediated cascade, FGFR4;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;FGFRL1 modulation of FGFR1 signaling;Signaling by FGFR3 point mutants in cancer;Post-translational protein phosphorylation	PE1	12
+NX_Q9GZW5	Putative SCAN domain-containing protein SCAND2P	306	34217	10.67	0	Nucleus	NA	NA	NA	NA	NA	PE5	15
+NX_Q9GZW8	Membrane-spanning 4-domains subfamily A member 7	240	26131	6.17	4	Membrane	NA	May be involved in signal transduction as a component of a multimeric receptor complex.	NA	Belongs to the MS4A family.	NA	PE2	11
+NX_Q9GZX3	Carbohydrate sulfotransferase 6	395	44099	10.03	1	Golgi apparatus membrane	Macular dystrophy, corneal	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures.	NA	Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.	Glycosaminoglycan biosynthesis - keratan sulfate;Keratan sulfate biosynthesis;Defective CHST6 causes MCDC1	PE1	16
+NX_Q9GZX5	Zinc finger protein 350	532	60011	8.92	0	Nucleoplasm;Nucleus matrix;Nucleus	NA	Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway;SUMOylation of transcription cofactors	PE1	19
+NX_Q9GZX6	Interleukin-22	179	20011	7.65	0	Secreted	NA	Cytokine that contributes to the inflammatory response in vivo.	NA	Belongs to the IL-10 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling	PE1	12
+NX_Q9GZX7	Single-stranded DNA cytosine deaminase	198	23954	9.5	0	Cytoplasm;Nucleus	Immunodeficiency with hyper-IgM 2	Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).	Probably monoubiquitinated on several residues by RNF126.;Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity.	Belongs to the cytidine and deoxycytidylate deaminase family.	Intestinal immune network for IgA production;Primary immunodeficiency	PE1	12
+NX_Q9GZX9	Twisted gastrulation protein homolog 1	223	25017	5.17	0	Cytosol;Centrosome;Secreted	NA	May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).	NA	Belongs to the twisted gastrulation protein family.	NA	PE1	18
+NX_Q9GZY0	Nuclear RNA export factor 2	626	71627	7.74	0	Nucleoplasm;Cytoplasm	NA	Involved in the export of mRNA from the nucleus to the cytoplasm.	NA	Belongs to the NXF family.	Ribosome biogenesis in eukaryotes;RNA transport;mRNA surveillance pathway;Influenza A;Herpes simplex infection;Ribosome biogenesis in eukaryotes;RNA transport;mRNA surveillance pathway;Influenza A;Herpes simplex infection;Transport of Mature mRNA derived from an Intron-Containing Transcript	PE1	X
+NX_Q9GZY1	Prostate and breast cancer overexpressed gene 1 protein	135	15722	9.77	0	Cytoplasm;Nucleus	NA	NA	NA	NA	NA	PE2	6
+NX_Q9GZY4	Cytochrome c oxidase assembly factor 1 homolog	146	16694	8.76	1	Mitochondrion inner membrane;Mitochondrion	NA	Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV.	NA	Belongs to the COA1 family.	NA	PE1	7
+NX_Q9GZY6	Linker for activation of T-cells family member 2	243	26550	4.69	1	Cell membrane	NA	Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.	May be polyubiquitinated.;Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.	NA	Role of LAT2/NTAL/LAB on calcium mobilization	PE1	7
+NX_Q9GZY8	Mitochondrial fission factor	342	38465	9.01	1	Mitochondrion outer membrane;Peroxisome;Mitochondrion;Synaptic vesicle	Encephalopathy due to defective mitochondrial and peroxisomal fission 2	Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.	NA	Belongs to the Tango11 family.	NA	PE1	2
+NX_Q9GZZ0	Homeobox protein Hox-D1	328	34093	9.15	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.	NA	Belongs to the Antp homeobox family. Labial subfamily.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	2
+NX_Q9GZZ1	N-alpha-acetyltransferase 50	169	19398	8.96	0	Cytoplasm;Nucleus	NA	N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:19744929, PubMed:22311970, PubMed:21900231, PubMed:27484799). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (PubMed:27484799). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (PubMed:19744929). Autoacetylates in vivo (PubMed:19744929). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (PubMed:19744929). Component of a N-alpha-acetyltransferase complex containing NAA10 and NAA15, but NAA50 does not influence the acetyltransferase activity of NAA10: this multiprotein complex probably constitutes the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (PubMed:16507339, PubMed:27484799). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (PubMed:17502424, PubMed:27422821).	NA	Belongs to the acetyltransferase family. GNAT subfamily.	NA	PE1	3
+NX_Q9GZZ6	Neuronal acetylcholine receptor subunit alpha-10	450	49705	8.2	4	Cell membrane;Postsynaptic cell membrane	NA	Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.	Neuroactive ligand-receptor interaction	PE1	11
+NX_Q9GZZ7	GDNF family receptor alpha-4	299	31670	10.47	0	Secreted;Cell membrane	NA	Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.	NA	Belongs to the GDNFR family.	RAF/MAP kinase cascade;NCAM1 interactions;RET signaling	PE1	20
+NX_Q9GZZ8	Extracellular glycoprotein lacritin	138	14246	5.44	0	Secreted	NA	Modulates secretion by lacrimal acinar cells.	NA	NA	NA	PE1	12
+NX_Q9GZZ9	Ubiquitin-like modifier-activating enzyme 5	404	44863	4.79	0	Golgi apparatus;Cytoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	Epileptic encephalopathy, early infantile, 44;Spinocerebellar ataxia, autosomal recessive, 24	E1-like enzyme which activates UFM1 and SUMO2.	NA	Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.	Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	3
+NX_Q9H000	Probable E3 ubiquitin-protein ligase makorin-2	416	46940	7.73	0	Cytoplasm;Nucleoplasm;Cytosol	NA	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	NA	NA	Protein modification; protein ubiquitination.	PE1	3
+NX_Q9H008	Phospholysine phosphohistidine inorganic pyrophosphate phosphatase	270	29165	5.8	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).	NA	Belongs to the HAD-like hydrolase superfamily.	Oxidative phosphorylation;Purine ribonucleoside monophosphate biosynthesis	PE1	10
+NX_Q9H009	Nascent polypeptide-associated complex subunit alpha-2	215	23223	4.68	0	Cytoplasm;Nucleus	NA	Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).	NA	Belongs to the NAC-alpha family.	NA	PE1	17
+NX_Q9H013	Disintegrin and metalloproteinase domain-containing protein 19	955	104997	8.75	1	Membrane;Cytoplasmic vesicle	NA	Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).	The precursor is cleaved by a furin endopeptidase.	NA	Invadopodia formation	PE1	5
+NX_Q9H015	Solute carrier family 22 member 4	551	62155	6.85	12	Membrane;Mitochondrion	Rheumatoid arthritis	Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Organic cation transport	PE1	5
+NX_Q9H019	Mitochondrial fission regulator 1-like	292	31957	5.77	0	Cytoplasm;Cell junction;Mitochondrion	NA	NA	NA	Belongs to the MTFR1 family.	NA	PE1	1
+NX_Q9H040	SprT-like domain-containing protein Spartan	489	55134	8.38	0	Nucleoplasm;Nucleus;Chromosome	Ruijs-Aalfs syndrome	Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.	NA	Belongs to the Spartan family.	Translesion Synthesis by POLH	PE1	1
+NX_Q9H061	Transmembrane protein 126A	195	21527	9.36	4	Nucleoplasm;Cytosol;Mitochondrion inner membrane;Mitochondrion	Optic atrophy 7 with or without auditory neuropathy	NA	NA	Belongs to the TMEM126 family.	NA	PE1	11
+NX_Q9H063	Repressor of RNA polymerase III transcription MAF1 homolog	256	28771	4.47	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Plays also a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:20887893, PubMed:17505538). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043).	Sumoylated with SUMO1 and SUMO2, mainly on Lys-35. Desumoylated by SENP1. SUMOylation promotes the ability of MAF1 to repress transcription and suppress colony formation.;Phosphorylated at Ser-60, Ser-68 and Ser-75; the major sites of phosphorylation. Nuclear accumulation correlates with a concomitant dephosphorylation. Phosphorylation may attenuate its RNA polymerase III-repressive function.	Belongs to the MAF1 family.	Regulation of PTEN gene transcription	PE1	8
+NX_Q9H069	Dynein regulatory complex subunit 3	523	61054	4.68	0	Cytoplasm;Cilium axoneme;Cilium;Flagellum axoneme	NA	Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.	NA	Belongs to the DRC3 family.	NA	PE1	17
+NX_Q9H074	Polyadenylate-binding protein-interacting protein 1	479	53525	4.71	0	Cytoplasm;Cytosol;Cell membrane	NA	Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.	NA	NA	RNA transport;Deadenylation of mRNA	PE1	5
+NX_Q9H078	Caseinolytic peptidase B protein homolog	707	78729	9.13	0	Mitochondrion	3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia	May function as a regulatory ATPase and be related to secretion/protein trafficking process.	NA	Belongs to the ClpA/ClpB family.	NA	PE1	11
+NX_Q9H079	KATNB1-like protein 1	304	34767	9.18	0	Cleavage furrow;Nucleoplasm;Spindle pole;Nucleus;Spindle;Midbody	NA	Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro.	NA	NA	NA	PE1	15
+NX_Q9H081	Protein MIS12 homolog	205	24140	5.5	0	Kinetochore;Nucleus	NA	Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108).	NA	Belongs to the mis12 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	17
+NX_Q9H082	Ras-related protein Rab-33B	229	25718	6.7	0	cis-Golgi network;Golgi apparatus;Golgi apparatus membrane	Smith-McCort dysplasia 2	Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation.	NA	Belongs to the small GTPase superfamily. Rab family.	Intra-Golgi traffic;TBC/RABGAPs;RAB geranylgeranylation	PE1	4
+NX_Q9H089	Large subunit GTPase 1 homolog	658	75225	5.96	0	Cajal body;Cytoplasm;Endoplasmic reticulum;Nucleoplasm;Cytosol;Nucleus	NA	GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable).	NA	Belongs to the TRAFAC class YlqF/YawG GTPase family. LSG1 subfamily.	Ribosome biogenesis in eukaryotes	PE1	3
+NX_Q9H091	Zinc finger MYND domain-containing protein 15	742	81860	6.38	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	Spermatogenic failure 14	Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.	NA	NA	NA	PE1	17
+NX_Q9H093	NUAK family SNF1-like kinase 2	628	69612	9.01	0	Nucleoplasm;Nucleolus;Nucleus;Cytosol	NA	Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.	Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylated in vitro.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	NA	PE1	1
+NX_Q9H094	Neuroblastoma breakpoint family member 3	633	72951	4.4	0	Cytoplasm	NA	NA	NA	Belongs to the NBPF family.	NA	PE2	1
+NX_Q9H095	Dynein regulatory complex protein 9	443	51918	6.18	0	Cytoplasm;Flagellum axoneme;Cilium;Flagellum;Cytosol;Cytoskeleton	NA	Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.	NA	Belongs to the DRC9 family.	NA	PE1	3
+NX_Q9H098	Protein FAM107B	131	15558	7.89	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the FAM107 family.	NA	PE1	10
+NX_Q9H0A0	RNA cytidine acetyltransferase	1025	115730	8.5	0	Midbody;Nucleolus	NA	RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621). MRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603).	Acetylation at Lys-426 is required to activation of rRNA transcription (PubMed:27993683). May be autoacetylated; however ability to autoacetylate in vivo requires additional evidences (PubMed:27993683).	Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol	PE1	11
+NX_Q9H0A3	Transmembrane protein 191A	160	17963	8.95	1	Membrane	NA	NA	NA	Belongs to the TMEM191 family.	NA	PE2	22
+NX_Q9H0A6	RING finger protein 32	362	41516	9.15	0	Cytoplasm;Cell membrane	NA	May play a role in sperm formation.	NA	NA	NA	PE1	7
+NX_Q9H0A8	COMM domain-containing protein 4	199	21764	6.89	0	Cytoplasm;Nucleoplasm;Nucleus;Cell membrane	NA	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.	NA	NA	Neddylation	PE1	15
+NX_Q9H0A9	Speriolin-like protein	340	37613	7.05	0	Cytoplasm;Cell membrane;Cytoplasmic vesicle;Cytosol;Nucleus	NA	NA	NA	Belongs to the speriolin family.	NA	PE1	21
+NX_Q9H0B3	IQ domain-containing protein N	1180	127693	10.25	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	19
+NX_Q9H0B6	Kinesin light chain 2	622	68935	6.72	0	Cytoplasm;Mitochondrion;Cell membrane;Nucleoplasm;Cytosol;Cytoskeleton	Spastic paraplegia, optic atrophy, and neuropathy	Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).	NA	Belongs to the kinesin light chain family.	Salmonella infection;MHC class II antigen presentation;Kinesins;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic	PE1	11
+NX_Q9H0B8	Cysteine-rich secretory protein LCCL domain-containing 2	497	55920	8.36	0	Golgi apparatus;Nucleoplasm;Secreted;Nucleolus	NA	Promotes matrix assembly.	NA	Belongs to the CRISP family.	Neutrophil degranulation	PE1	16
+NX_Q9H0C1	Zinc finger MYND domain-containing protein 12	365	41818	5.82	0	Cytoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	1
+NX_Q9H0C2	ADP/ATP translocase 4	315	35022	9.91	6	Mitochondrion inner membrane;Mitochondrion;Flagellum	NA	Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Calcium signaling pathway;Parkinson's disease;Huntington's disease;HTLV-I infection	PE1	4
+NX_Q9H0C3	Transmembrane protein 117	514	60185	8.67	8	Endoplasmic reticulum;Cell membrane	NA	Involved in endoplasmic reticulum (ER) stress-induced cell death pathway.	NA	Belongs to the TMEM117 family.	NA	PE1	12
+NX_Q9H0C5	BTB/POZ domain-containing protein 1	482	52771	5.79	0	Nucleoplasm;Cytoplasm;Cytosol	NA	Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity).	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	15
+NX_Q9H0C8	Integrin-linked kinase-associated serine/threonine phosphatase 2C	392	42907	6.68	0	Cytoplasm;Nucleoplasm	NA	Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.	NA	Belongs to the PP2C family.	NA	PE1	2
+NX_Q9H0D2	Zinc finger protein 541	1346	145587	8.28	0	Nucleoplasm;Cytosol;Nucleus	NA	Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.	NA	NA	NA	PE1	19
+NX_Q9H0D6	5'-3' exoribonuclease 2	950	108582	7.26	0	Nucleoplasm;Nucleolus	NA	Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).	NA	Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.	Ribosome biogenesis in eukaryotes;RNA degradation;Association of TriC/CCT with target proteins during biosynthesis;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	20
+NX_Q9H0E2	Toll-interacting protein	274	30282	5.68	0	Cytoplasm;Endosome;Cytosol;Cell membrane	NA	Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).	Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.	Belongs to the tollip family.	Toll-like receptor signaling pathway;Neutrophil degranulation;Interleukin-1 signaling	PE1	11
+NX_Q9H0E3	Histone deacetylase complex subunit SAP130	1048	110324	9.83	0	Nucleus speckle;Nucleus	NA	Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.	Sumoylated with SUMO1.;Acetylated.	Belongs to the SAP130 family.	HATs acetylate histones;NoRC negatively regulates rRNA expression	PE1	2
+NX_Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	712	81185	8.21	0	Nucleolus;Nucleus;Cytoskeleton	NA	Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.	Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination and is degraded by the proteasome.;Dephosphorylated by CTDP1.	Belongs to the peptidase C19 family. USP44 subfamily.	Ub-specific processing proteases	PE1	12
+NX_Q9H0E9	Bromodomain-containing protein 8	1235	135336	4.52	0	Nucleoplasm;Mitochondrion;Nucleus	NA	May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR).;Stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.	NA	NA	HATs acetylate histones	PE1	5
+NX_Q9H0F5	E3 ubiquitin-protein ligase RNF38	515	57595	7.68	0	Nucleoplasm;Nucleus	NA	Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.	NA	NA	Protein modification; protein ubiquitination.	PE1	9
+NX_Q9H0F6	Sharpin	387	39949	5.53	0	Nucleoplasm;Cytosol;Synapse	NA	Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.	NA	NA	Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Neurexins and neuroligins	PE1	8
+NX_Q9H0F7	ADP-ribosylation factor-like protein 6	186	21097	8.72	0	Cilium basal body;Nucleoplasm;Cilium axoneme;Cilium membrane;Cytoplasmic vesicle	Retinitis pigmentosa 55;Bardet-Biedl syndrome 3	May be required for proper retinal function and organization (By similarity).;Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729).	NA	Belongs to the small GTPase superfamily. Arf family.	BBSome-mediated cargo-targeting to cilium	PE1	3
+NX_Q9H0G5	Nuclear speckle splicing regulatory protein 1	558	66390	8.9	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	RNA-binding protein that mediates pre-mRNA alternative splicing regulation.	NA	Belongs to the NSRP1 family.	NA	PE1	17
+NX_Q9H0H0	Integrator complex subunit 2	1204	134323	5.72	1	Cytoplasm;Nucleus membrane;Nucleus	NA	Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).	NA	Belongs to the Integrator subunit 2 family.	RNA polymerase II transcribes snRNA genes	PE1	17
+NX_Q9H0H3	Kelch-like protein 25	589	65923	6.1	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	15
+NX_Q9H0H5	Rac GTPase-activating protein 1	632	71027	9.08	0	Cytoplasm;Cleavage furrow;Cell membrane;Acrosome;Nucleoplasm;Nucleus envelope;Spindle;Nucleus;Midbody ring	NA	Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.	Phosphorylated at multiple sites in the midbody during cytokinesis. Phosphorylation by AURKB on Ser-387 at the midbody is, at least in part, responsible for exerting its latent GAP activity towards RhoA. Phosphorylation on multiple serine residues by PLK1 enhances its association with ECT2 and is critical for cleavage furrow formation.;RACGAP1 is phosphorylated by AURKB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	MHC class II antigen presentation;Rho GTPase cycle;Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	12
+NX_Q9H0H9	Putative cytochrome P450 family member 4F30	118	12413	9.49	0	NA	NA	NA	NA	NA	NA	PE5	2
+NX_Q9H0I2	Enkurin domain-containing protein 1	346	38759	9.84	0	Cytosol;Centrosome;Cell membrane;Cytoskeleton	NA	NA	NA	NA	NA	PE1	16
+NX_Q9H0I3	Coiled-coil domain-containing protein 113	377	44220	8.75	0	Cytoplasm;Centriolar satellite;Nucleus	NA	Component of centriolar satellites contributing to primary cilium formation.	NA	NA	NA	PE1	16
+NX_Q9H0I9	Transketolase-like protein 2	626	67877	5.9	0	Cytoplasm	NA	Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis.	NA	Belongs to the transketolase family.	Pentose phosphate pathway;Metabolic pathways	PE1	4
+NX_Q9H0J4	Glutamine-rich protein 2	1663	180827	6.25	0	Cytoplasm;Nucleus membrane;Nucleoplasm;Flagellum;Cytoplasmic vesicle;Nucleus	Spermatogenic failure 35	Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility.	NA	NA	NA	PE1	17
+NX_Q9H0J9	Protein mono-ADP-ribosyltransferase PARP12	701	79064	8.84	0	Nucleoplasm;Nucleus	NA	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.	Auto-mono-ADP-ribosylated.	NA	NA	PE1	7
+NX_Q9H0K1	Serine/threonine-protein kinase SIK2	926	103915	5.7	0	Golgi apparatus;Cytoplasm	NA	Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.	Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.;Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	NA	PE1	11
+NX_Q9H0K4	Radial spoke head protein 6 homolog A	717	80913	4.36	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the flagellar radial spoke RSP4/6 family.	NA	PE1	19
+NX_Q9H0K6	Pseudouridylate synthase 7 homolog-like protein	701	80700	7.31	0	Nucleus speckle;Nucleus	NA	Pseudouridylate synthase that catalyzes pseudouridylation of RNAs.	NA	Belongs to the pseudouridine synthase TruD family.	NA	PE1	12
+NX_Q9H0L4	Cleavage stimulation factor subunit 2 tau variant	616	64437	6.79	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity).	NA	NA	mRNA surveillance pathway;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	10
+NX_Q9H0M0	NEDD4-like E3 ubiquitin-protein ligase WWP1	922	105202	5.64	0	Golgi apparatus;Cytoplasm;Cell membrane;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.	Auto-ubiquitinated and ubiquitinated by RNF11.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Stimuli-sensing channels;Downregulation of ERBB4 signaling;Regulation of RUNX2 expression and activity	PE1	8
+NX_Q9H0M4	Zinc finger CW-type PWWP domain protein 1	648	72007	7.47	0	Golgi apparatus	NA	NA	NA	NA	NA	PE1	7
+NX_Q9H0M5	Zinc finger protein 700	742	86232	9.15	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9H0N0	Ras-related protein Rab-6C	254	28355	7.58	0	Golgi apparatus;Cytoplasm;Centrosome;Nucleus	NA	May be involved in the regulation of centrosome duplication and cell cycle progression.	NA	Belongs to the small GTPase superfamily. Rab family.	NA	PE1	2
+NX_Q9H0N5	Pterin-4-alpha-carbinolamine dehydratase 2	130	14365	9.17	0	Cytoplasm;Nucleus;Cell membrane	NA	Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.;Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity).	NA	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.	NA	PE1	5
+NX_Q9H0P0	Cytosolic 5'-nucleotidase 3A	336	37948	6.67	0	Endoplasmic reticulum;Cytoplasm;Mitochondrion;Nucleus	P5N deficiency	Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458).	NA	Belongs to the pyrimidine 5'-nucleotidase family.	Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Pyrimidine catabolism	PE1	7
+NX_Q9H0P7	Putative uncharacterized protein encoded by AGPAT4-IT1	198	20949	6.01	0	Cytoplasm	NA	NA	NA	NA	NA	PE5	6
+NX_Q9H0Q0	Protein FAM49A	323	37313	5.71	0	Cytoplasm;Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the FAM49 family.	NA	PE1	2
+NX_Q9H0Q3	FXYD domain-containing ion transport regulator 6	95	10542	5.05	1	Golgi apparatus;Cell membrane;Nucleus membrane;Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the FXYD family.	Ion transport by P-type ATPases;Ion homeostasis	PE1	11
+NX_Q9H0R1	AP-5 complex subunit mu-1	490	54767	6.17	0	Cytosol;Lysosome membrane;Late endosome membrane	NA	As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death.	NA	Belongs to the adaptor complexes medium subunit family.	NA	PE1	14
+NX_Q9H0R3	Transmembrane protein 222	208	23230	6.04	3	Membrane;Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q9H0R4	Haloacid dehalogenase-like hydrolase domain-containing protein 2	259	28536	5.84	0	Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the HAD-like hydrolase superfamily.	NA	PE1	18
+NX_Q9H0R5	Guanylate-binding protein 3	595	68114	6.11	0	Cytoplasm;Perinuclear region;Golgi apparatus membrane	NA	Exhibits antiviral activity against influenza virus.	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	Interferon gamma signaling	PE1	1
+NX_Q9H0R6	Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial	528	57460	5.47	0	Cytoplasmic vesicle;Mitochondrion;Centrosome	NA	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).	NA	Belongs to the amidase family. GatA subfamily.	NA	PE1	6
+NX_Q9H0R8	Gamma-aminobutyric acid receptor-associated protein-like 1	117	14044	8.67	0	Cytoplasm;Golgi apparatus;Cytoplasmic vesicle membrane;Endoplasmic reticulum;Autophagosome;Nucleus;Cytoskeleton	NA	Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:16431922, PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, paticipates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).	The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL1-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL1-II (By similarity). ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (PubMed:20404487).;The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.	Belongs to the ATG8 family.	Regulation of autophagy;GABAergic synapse;Macroautophagy	PE1	12
+NX_Q9H0S4	Probable ATP-dependent RNA helicase DDX47	455	50647	9.18	0	Nucleolus;Nucleus	NA	Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors.	NA	Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	12
+NX_Q9H0T7	Ras-related protein Rab-17	212	23491	7.7	0	Cytoplasm;Melanosome;Recycling endosome membrane;Dendrite;Nucleus	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.	NA	Belongs to the small GTPase superfamily. Rab family.	RAB geranylgeranylation	PE1	2
+NX_Q9H0U3	Magnesium transporter protein 1	335	38037	9.68	4	Endoplasmic reticulum;Endoplasmic reticulum membrane;Cell membrane	Immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia	May be involved in Mg(2+) transport in epithelial cells.;Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.	NA	Belongs to the OST3/OST6 family.	Protein modification; protein glycosylation.;Miscellaneous transport and binding events;Asparagine N-linked glycosylation;Neutrophil degranulation	PE1	X
+NX_Q9H0U4	Ras-related protein Rab-1B	201	22171	5.55	0	Golgi apparatus;Cytoplasm;Preautophagosomal structure membrane;Membrane;Endoplasmic reticulum;Perinuclear region	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity).	Phosphocholinated at Ser-76 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB.;Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).;AMPylation at Tyr-77 by L.pneumophila DrrA occurs in the switch 2 region and leads to moderate inactivation of the GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB1B constitutively active. It is later de-AMPylated by L.pneumophila SidD, releasing RAB1B from bacterial phagosomes.	Belongs to the small GTPase superfamily. Rab family.	Legionellosis;Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	11
+NX_Q9H0U6	39S ribosomal protein L18, mitochondrial	180	20577	9.63	0	Mitochondrion	NA	Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.	NA	Belongs to the universal ribosomal protein uL18 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	6
+NX_Q9H0U9	Testis-specific Y-encoded-like protein 1	437	49192	5.36	0	Nucleoplasm;Nucleolus;Nucleus	Sudden infant death with dysgenesis of the testes syndrome	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	6
+NX_Q9H0V1	Transmembrane protein 168	697	79755	8.34	11	Membrane;Golgi apparatus;Cytosol	NA	NA	NA	Belongs to the TMEM168 family.	NA	PE1	7
+NX_Q9H0V9	VIP36-like protein	348	39711	8.55	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Golgi apparatus membrane	Mental retardation, autosomal recessive 52	May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.	NA	NA	COPII-mediated vesicle transport;Cargo concentration in the ER	PE1	2
+NX_Q9H0W5	Coiled-coil domain-containing protein 8	538	59374	8.72	0	Cytoplasm;Cell membrane;Nucleoplasm;Centrosome;Cytosol	3M syndrome 3	Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695).	NA	NA	Neddylation	PE1	19
+NX_Q9H0W7	THAP domain-containing protein 2	228	26260	10.17	0	Golgi apparatus;Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	12
+NX_Q9H0W8	Protein SMG9	520	57651	6.52	0	Cytoplasm;Cytosol;Mitochondrion;Nucleus	Heart and brain malformation syndrome	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity).	Phosphorylated by SMG1.	Belongs to the SMG9 family.	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PE1	19
+NX_Q9H0W9	Ester hydrolase C11orf54	315	35117	6.23	0	Nucleoplasm;Nucleus	NA	Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.	NA	NA	NA	PE1	11
+NX_Q9H0X4	Protein FAM234A	552	59660	5.84	1	Membrane;Nucleoplasm;Mitochondrion;Cell membrane	NA	NA	NA	Belongs to the FAM234 family.	NA	PE1	16
+NX_Q9H0X6	RING finger protein 208	261	27964	7.45	0	Cytoplasm;Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	9
+NX_Q9H0X9	Oxysterol-binding protein-related protein 5	879	98616	7.29	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Cytoplasmic vesicle	NA	Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).	NA	Belongs to the OSBP family.	Acyl chain remodelling of PS	PE1	11
+NX_Q9H0Y0	Ubiquitin-like-conjugating enzyme ATG10	220	25279	5.35	0	Nucleolus;Cytoplasm;Nucleoplasm;Nucleus	NA	E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.	NA	Belongs to the ATG10 family.	Macroautophagy	PE1	5
+NX_Q9H0Z9	RNA-binding protein 38	239	25498	8.76	0	Nucleoplasm;Cytosol;Nucleus	NA	But not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.;RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest.;(Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication.	NA	Belongs to the RBM38 family.	NA	PE1	20
+NX_Q9H106	Signal-regulatory protein delta	197	21687	9.56	0	Secreted	NA	NA	NA	NA	NA	PE1	20
+NX_Q9H112	Cystatin-11	138	16506	6.51	0	Secreted	NA	Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.	NA	Belongs to the cystatin family.	NA	PE1	20
+NX_Q9H114	Cystatin-like 1	145	16989	9.84	0	Secreted	NA	NA	NA	Belongs to the cystatin family.	NA	PE2	20
+NX_Q9H115	Beta-soluble NSF attachment protein	298	33557	5.32	0	Membrane	NA	Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.	NA	Belongs to the SNAP family.	COPII-mediated vesicle transport;Intra-Golgi traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network	PE1	20
+NX_Q9H116	GDNF-inducible zinc finger protein 1	711	80492	8.11	0	Nucleoplasm;Cytoplasm;Nucleolus	Joint laxity, short stature, and myopia	Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	20
+NX_Q9H147	Deoxynucleotidyltransferase terminal-interacting protein 1	329	37013	9.11	0	Nucleoplasm;Nucleus;Nucleolus	NA	Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.	NA	NA	NA	PE1	20
+NX_Q9H156	SLIT and NTRK-like protein 2	845	95404	7.95	1	Membrane;Cell membrane	NA	It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Suppresses neurite outgrowth (By similarity).	NA	Belongs to the SLITRK family.	Receptor-type tyrosine-protein phosphatases	PE1	X
+NX_Q9H158	Protocadherin alpha-C1	963	103942	5.05	1	Nucleoplasm;Cell membrane;Nucleolus;Cytoplasmic vesicle	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE2	5
+NX_Q9H159	Cadherin-19	772	87002	4.62	1	Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	NA	PE1	18
+NX_Q9H160	Inhibitor of growth protein 2	280	32808	8.17	0	Golgi apparatus;Nucleoplasm;Cytosol;Nucleus	NA	Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).	Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.	Belongs to the ING family.	PI5P Regulates TP53 Acetylation;SUMOylation of transcription cofactors	PE1	4
+NX_Q9H161	Homeobox protein aristaless-like 4	411	44241	8.56	0	Nucleoplasm;Nucleus	Potocki-Shaffer syndrome;Frontonasal dysplasia 2;Parietal foramina 2;Craniosynostosis 5	Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.	NA	Belongs to the paired homeobox family.	NA	PE1	11
+NX_Q9H165	B-cell lymphoma/leukemia 11A	835	91197	6.15	0	Cytoplasm;Nucleoplasm;Nucleus	Intellectual developmental disorder with persistence of fetal hemoglobin	Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity).	Sumoylated with SUMO1.	NA	NA	PE1	2
+NX_Q9H169	Stathmin-4	189	22071	5.76	0	Golgi apparatus;Growth cone;Axon;Cytoplasmic vesicle	NA	Exhibits microtubule-destabilizing activity.	NA	Belongs to the stathmin family.	NA	PE1	8
+NX_Q9H171	Z-DNA-binding protein 1	429	46343	6.29	0	NA	NA	Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).	NA	NA	Cytosolic DNA-sensing pathway;RIP-mediated NFkB activation via ZBP1;Regulation of innate immune responses to cytosolic DNA;IRF3 mediated activation of type 1 IFN;ZBP1(DAI) mediated induction of type I IFNs	PE1	20
+NX_Q9H172	ATP-binding cassette sub-family G member 4	646	71896	8.49	6	Membrane	NA	May be involved in macrophage lipid homeostasis.	NA	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.	ABC transporters;ABC transporters in lipid homeostasis	PE1	11
+NX_Q9H173	Nucleotide exchange factor SIL1	461	52085	5.27	0	Endoplasmic reticulum lumen	Marinesco-Sjoegren syndrome	Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.	N-glycosylated.	Belongs to the SIL1 family.	Protein processing in endoplasmic reticulum	PE1	5
+NX_Q9H175	Cysteine/serine-rich nuclear protein 2	543	59591	4.68	0	Nucleus speckle;Nucleus	NA	Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis.	NA	Belongs to the AXUD1 family.	NA	PE1	12
+NX_Q9H190	Syntenin-2	292	31594	9.15	0	Cytoplasm;Nucleus speckle;Cell membrane;Nucleolus;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).	NA	NA	NA	PE1	20
+NX_Q9H195	Mucin-3B	1237	131402	5.28	1	Membrane	NA	Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity).	Highly O-glycosylated and probably also N-glycosylated.	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE2	7
+NX_Q9H1A3	Methyltransferase-like protein 9	318	36536	6.96	0	Nucleoplasm;Cytosol;Cell junction	NA	NA	NA	Belongs to the DREV family.	NA	PE1	16
+NX_Q9H1A4	Anaphase-promoting complex subunit 1	1944	216500	5.88	0	Cytoplasmic vesicle	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.	Belongs to the APC1 family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	2
+NX_Q9H1A7	DNA-directed RNA polymerase II subunit RPB11-b2	115	13092	5.88	0	Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).	NA	Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.	NA	PE2	7
+NX_Q9H1B4	Nuclear RNA export factor 5	397	45628	9.1	0	Cytoplasm;Nucleus	NA	Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.	NA	Belongs to the NXF family.	Ribosome biogenesis in eukaryotes;RNA transport;mRNA surveillance pathway;Influenza A;Herpes simplex infection	PE2	X
+NX_Q9H1B5	Xylosyltransferase 2	865	96767	8.5	1	Cytosol;Secreted;Nucleus;Golgi apparatus membrane	Spondyloocular syndrome;Pseudoxanthoma elasticum	Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein.	Contains disulfide bonds.	Belongs to the glycosyltransferase 14 family. XylT subfamily.	Glycan metabolism; heparan sulfate biosynthesis.;Glycan metabolism; chondroitin sulfate biosynthesis.;Glycosaminoglycan biosynthesis - chondroitin sulfate;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;A tetrasaccharide linker sequence is required for GAG synthesis	PE1	17
+NX_Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	796	82659	8.56	0	Nucleoplasm;Nucleus	Neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures	Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity).	NA	Belongs to the IRF2BP family.	Protein modification; protein ubiquitination.	PE1	14
+NX_Q9H1C0	Lysophosphatidic acid receptor 5	372	41347	10.22	7	Cell membrane	NA	Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;G alpha (q) signalling events;Lysosphingolipid and LPA receptors	PE1	12
+NX_Q9H1C3	Glycosyltransferase 8 domain-containing protein 2	349	40026	6.57	1	Membrane;Golgi apparatus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the glycosyltransferase 8 family.	NA	PE1	12
+NX_Q9H1C4	Protein unc-93 homolog B1	597	66631	6.48	12	Endoplasmic reticulum membrane;Nucleoplasm;Endosome;Phagosome;Lysosome	Encephalopathy, acute, infection-induced, Herpes-specific, 1	Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.	N-glycosylated.	Belongs to the unc-93 family.	Trafficking and processing of endosomal TLR;UNC93B1 deficiency - HSE	PE1	11
+NX_Q9H1C7	Cysteine-rich and transmembrane domain-containing protein 1	97	10631	4.2	1	Membrane	NA	NA	NA	Belongs to the CYSTM1 family.	Neutrophil degranulation	PE1	5
+NX_Q9H1D0	Transient receptor potential cation channel subfamily V member 6	765	87286	7.86	6	Cell membrane	Hyperparathyroidism, transient neonatal	Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.	Glycosylated.;Phosphorylation at Tyr-201 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at this site by PTPN1 (By similarity). Phosphorylation by PRKCA at the calmodulin binding site delays channel inactivation (PubMed:11248124).	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily.	Salivary secretion;Mineral absorption;TRP channels	PE1	7
+NX_Q9H1D9	DNA-directed RNA polymerase III subunit RPC6	316	35684	5.79	0	Nucleoplasm;Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628).	NA	Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	20
+NX_Q9H1E1	Ribonuclease 7	156	17419	9.76	0	Secreted	NA	Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:17150966). Causes loss of bacterial membrane integrity (PubMed:17150966). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:17150966).	NA	Belongs to the pancreatic ribonuclease family.	Antimicrobial peptides	PE1	14
+NX_Q9H1E3	Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1	243	27296	5	0	Nucleoplasm;Nucleolus;Nucleus	NA	NA	Phosphorylated by CDK1 and casein kinase.	NA	NA	PE1	1
+NX_Q9H1E5	Thioredoxin-related transmembrane protein 4	349	38952	4.31	1	Nucleus inner membrane;Nucleus membrane	NA	NA	NA	NA	NA	PE1	20
+NX_Q9H1F0	WAP four-disulfide core domain protein 10A	79	8943	8.8	0	Secreted	NA	NA	NA	NA	NA	PE2	20
+NX_Q9H1H1	Gametocyte-specific factor 1-like	148	16872	6.3	0	Nucleolus	NA	NA	NA	Belongs to the UPF0224 (FAM112) family.	NA	PE1	20
+NX_Q9H1H9	Kinesin-like protein KIF13A	1805	202308	5.43	0	Endosome membrane;Centrosome;Midbody;Golgi apparatus membrane	NA	Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Association of TriC/CCT with target proteins during biosynthesis	PE1	6
+NX_Q9H1I8	Activating signal cointegrator 1 complex subunit 2	757	86360	5.02	0	Nucleus speckle;Focal adhesion;Nucleoplasm;Cytosol;Nucleus	NA	Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).	NA	Belongs to the ASCC2 family.	ALKBH3 mediated reversal of alkylation damage	PE1	22
+NX_Q9H1J1	Regulator of nonsense transcripts 3A	476	54696	9.12	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.	NA	Belongs to the RENT3 family.	RNA transport;mRNA surveillance pathway;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Regulation of expression of SLITs and ROBOs	PE1	13
+NX_Q9H1J5	Protein Wnt-8a	351	38849	8.1	0	Extracellular matrix;Secreted	NA	Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.	Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).;Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8A.	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors);TCF dependent signaling in response to WNT;Disassembly of the destruction complex and recruitment of AXIN to the membrane	PE1	5
+NX_Q9H1J7	Protein Wnt-5b	359	40323	8.8	0	Cytoplasmic vesicle;Extracellular matrix	NA	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;PCP/CE pathway	PE1	12
+NX_Q9H1K0	Rabenosyn-5	784	88870	5.36	0	Early endosome membrane;Cytoplasmic vesicle;Cell membrane	NA	Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388).	NA	NA	Factors involved in megakaryocyte development and platelet production;Toll Like Receptor 9 (TLR9) Cascade	PE1	3
+NX_Q9H1K1	Iron-sulfur cluster assembly enzyme ISCU, mitochondrial	167	17999	9.54	0	Cytoplasm;Cytosol;Mitochondrion;Nucleus	Myopathy with exercise intolerance Swedish type	Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).;Functions as a cytoplasmic scaffold protein for the de novo synthesis of iron-sulfur clusters in the cytoplasm.	NA	Belongs to the NifU family.	Mitochondrial iron-sulfur cluster biogenesis	PE1	12
+NX_Q9H1K4	Mitochondrial glutamate carrier 2	315	33849	9.39	6	Mitochondrion inner membrane	NA	Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Organic anion transporters	PE1	22
+NX_Q9H1K6	Talin rod domain-containing protein 1	362	37758	8.54	0	Nucleoplasm;Cytosol	NA	Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.	NA	NA	NA	PE1	15
+NX_Q9H1L0	Uncharacterized protein MIR1-1HG	117	12410	6.4	0	NA	NA	NA	NA	NA	NA	PE4	20
+NX_Q9H1M0	Nucleoporin-62 C-terminal-like protein	184	20837	4.41	0	NA	NA	NA	NA	Belongs to the nucleoporin NSP1/NUP62 family.	NA	PE1	X
+NX_Q9H1M3	Beta-defensin 129	183	20299	9.04	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	20
+NX_Q9H1M4	Beta-defensin 127	99	11343	9.05	0	Secreted	NA	Has antibacterial activity.	NA	Belongs to the beta-defensin family.	Beta defensins;Defensins	PE1	20
+NX_Q9H1N7	Adenosine 3'-phospho 5'-phosphosulfate transporter 2	401	44593	9.34	10	Golgi apparatus membrane	NA	Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon.	NA	Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.	Transport and synthesis of PAPS;Transport of nucleotide sugars	PE1	6
+NX_Q9H1P3	Oxysterol-binding protein-related protein 2	480	55201	5.94	0	Cytosol;Lipid droplet;Cell membrane	Deafness, autosomal dominant, 67	Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane (PubMed:30581148). Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate (PubMed:30581148). Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) (PubMed:17428193, PubMed:19224871, PubMed:30581148).	NA	Belongs to the OSBP family.	Synthesis of bile acids and bile salts	PE1	20
+NX_Q9H1P6	Uncharacterized protein C20orf85	137	15719	8.72	0	NA	NA	NA	NA	NA	NA	PE1	20
+NX_Q9H1Q7	PC-esterase domain-containing protein 1A	454	51782	6.41	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the PC-esterase family.	NA	PE1	20
+NX_Q9H1R2	Dual specificity protein phosphatase 15	295	31882	8.77	0	Cytoplasm;Cytosol;Cell membrane	NA	May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).;May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	20
+NX_Q9H1R3	Myosin light chain kinase 2, skeletal/cardiac muscle	596	64685	6.6	0	Endoplasmic reticulum;Cytoplasm	Cardiomyopathy, familial hypertrophic	Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.	NA	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	Calcium signaling pathway;Vascular smooth muscle contraction;Focal adhesion;Regulation of actin cytoskeleton;Gastric acid secretion	PE1	20
+NX_Q9H1U4	Multiple epidermal growth factor-like domains protein 9	602	62984	5.45	1	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	9
+NX_Q9H1U9	Solute carrier family 25 member 51	297	33672	9.51	6	Mitochondrion inner membrane	NA	NA	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	9
+NX_Q9H1V8	Sodium-dependent neutral amino acid transporter SLC6A17	727	81001	5.68	12	Golgi apparatus;Postsynapse;Nucleolus;Nucleoplasm;Presynapse;Synaptic vesicle membrane	Mental retardation, autosomal recessive 48	Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A17 subfamily.	NA	PE1	1
+NX_Q9H1X1	Radial spoke head protein 9 homolog	276	31292	5.28	0	Cilium axoneme	Ciliary dyskinesia, primary, 12	Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules.	NA	Belongs to the flagellar radial spoke RSP9 family.	NA	PE1	6
+NX_Q9H1X3	DnaJ homolog subfamily C member 25	360	42404	9.2	3	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the DNAJC25 family.	NA	PE1	9
+NX_Q9H1Y0	Autophagy protein 5	275	32447	5.48	0	Cytoplasm;Preautophagosomal structure membrane;Centrosome	Spinocerebellar ataxia, autosomal recessive, 25	(Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601).;May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.;Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.	Acetylated by EP300.;Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.	Belongs to the ATG5 family.	Regulation of autophagy;RIG-I-like receptor signaling pathway;Shigellosis;Macroautophagy;Negative regulators of DDX58/IFIH1 signaling;Pink/Parkin Mediated Mitophagy;Receptor Mediated Mitophagy	PE1	6
+NX_Q9H1Y3	Opsin-3	402	44873	9.3	7	Membrane;Nucleoplasm	NA	May play a role in encephalic photoreception.	NA	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	G alpha (i) signalling events;Opsins	PE1	1
+NX_Q9H1Z4	WD repeat-containing protein 13	485	53696	9.33	0	Nucleoplasm;Centriolar satellite;Nucleus;Cell membrane	NA	NA	NA	NA	NA	PE1	X
+NX_Q9H1Z8	Augurin	148	17183	8.57	0	Cytoplasm;Apical cell membrane;Secreted	NA	Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity).	NA	Belongs to the augurin family.	NA	PE1	2
+NX_Q9H1Z9	Tetraspanin-10	355	36498	5.57	3	Membrane	NA	Regulates maturation of the transmembrane metalloprotease ADAM10.	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	17
+NX_Q9H201	Epsin-3	632	68222	5.64	0	Clathrin-coated vesicle;Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Perinuclear region;Nucleus	NA	NA	NA	Belongs to the epsin family.	Endocytosis	PE1	17
+NX_Q9H204	Mediator of RNA polymerase II transcription subunit 28	178	19520	5.39	0	Membrane;Cytoplasm;Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.	MED28 is phosphorylated by FYN (Phosphotyrosine:PTM-0255)	Belongs to the Mediator complex subunit 28 family.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	4
+NX_Q9H205	Olfactory receptor 2AG1	316	35270	8.38	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE1	11
+NX_Q9H207	Olfactory receptor 10A5	317	35519	9.06	7	Cell membrane	NA	Odorant receptor (Potential). May be involved in taste perception.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9H208	Olfactory receptor 10A2	303	33817	9.12	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9H209	Olfactory receptor 10A4	315	35117	7.56	7	Cell membrane	NA	Odorant receptor (Potential). May be involved in taste perception.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9H210	Olfactory receptor 2D2	308	34172	9.31	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9H211	DNA replication factor Cdt1	546	60390	9.82	0	Nucleoplasm;Nucleus;Kinetochore	Meier-Gorlin syndrome 4	Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity).	Two independent E3 ubiquitin ligase complexes, SCF(SKP2) and the DCX(DTL) complex, mediated CDT1 degradation in S phase. Ubiquitinated by the DCX(DTL) complex, in response to DNA damage, leading to its degradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Phosphorylation at Thr-29 by CDK2 targets CDT1 for ubiquitination by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). The interaction with GMNN protects it against ubiquitination. Deubiquitinated by USP37 (PubMed:27296872).;Phosphorylation by cyclin A-dependent kinases at Thr-29 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). Phosphorylated at Thr-29 by MAPK8/JNK1, which blocks replication licensing in response to stress (PubMed:21856198). Binding to GMNN is not affected by phosphorylation.;CDT1 is phosphorylated by CDK4	Belongs to the Cdt1 family.	CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;G1/S-Specific Transcription	PE1	16
+NX_Q9H213	Melanoma-associated antigen H1	219	24441	9.05	0	Nucleolus	NA	NA	NA	NA	NA	PE1	X
+NX_Q9H221	ATP-binding cassette sub-family G member 8	673	75679	8.52	6	Cytoplasmic vesicle;Apical cell membrane;Cell membrane	Gallbladder disease 4;Sitosterolemia	ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356).	N-glycosylated.	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.	ABC transporters;Fat digestion and absorption;Bile secretion;ABC transporters in lipid homeostasis;Defective ABCG8 causes gallbladder disease 4 and sitosterolemia;Defective ABCG5 causes sitosterolemia	PE1	2
+NX_Q9H222	ATP-binding cassette sub-family G member 5	651	72504	9.15	6	Apical cell membrane;Cell membrane	Sitosterolemia	ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11138003, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11138003, PubMed:15054092). The heterodimer with ABCG8 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356).	N-glycosylated.	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.	ABC transporters;Fat digestion and absorption;Bile secretion;ABC transporters in lipid homeostasis;Defective ABCG8 causes gallbladder disease 4 and sitosterolemia;Defective ABCG5 causes sitosterolemia	PE1	2
+NX_Q9H223	EH domain-containing protein 4	541	61175	6.33	0	Early endosome membrane;Recycling endosome membrane;Cell membrane	NA	ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport.	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.	Endocytosis	PE1	15
+NX_Q9H227	Cytosolic beta-glucosidase	469	53696	5.39	0	Cytosol	NA	Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (PubMed:11389701, PubMed:11784319, PubMed:20728381, PubMed:26724485, PubMed:17595169). Has a significant glucosylceramidase activity in vitro (PubMed:26724485, PubMed:17595169). However, that activity is relatively low and its significance in vivo is not clear (PubMed:26724485, PubMed:17595169, PubMed:20728381). Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph (PubMed:17595169). However, the in vivo relevance of these activities is unclear (PubMed:17595169). It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (PubMed:11784319). Could also play a role in the catabolism of cytosolic sialyl free N-glycans (PubMed:26193330).	The N-terminus is blocked.	Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.	Cyanoamino acid metabolism;Starch and sucrose metabolism;Glycosphingolipid metabolism	PE1	4
+NX_Q9H228	Sphingosine 1-phosphate receptor 5	398	41775	9.86	7	Cell membrane	NA	Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Lysosphingolipid and LPA receptors	PE1	19
+NX_Q9H237	Protein-serine O-palmitoleoyltransferase porcupine	461	52318	9.08	8	Cytoplasmic vesicle;Endoplasmic reticulum membrane	Focal dermal hypoplasia	Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors.	NA	Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.	Wnt signaling pathway;WNT ligand biogenesis and trafficking;WNT ligand secretion is abrogated by the PORCN inhibitor LGK974	PE1	X
+NX_Q9H239	Matrix metalloproteinase-28	520	58939	9.7	0	Extracellular matrix;Nucleoplasm;Focal adhesion	NA	Can degrade casein. Could play a role in tissues homeostasis and repair.	The precursor is cleaved by a furin endopeptidase.	Belongs to the peptidase M10A family.	NA	PE1	17
+NX_Q9H244	P2Y purinoceptor 12	342	39439	9.6	7	Cell membrane	Bleeding disorder, platelet-type 8	Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;P2Y receptors;ADP signalling through P2Y purinoceptor 12	PE1	3
+NX_Q9H246	Uncharacterized protein C1orf21	121	13865	5.17	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q9H251	Cadherin-23	3354	369494	4.5	1	Cell membrane	Usher syndrome 1D;Deafness, autosomal recessive, 12;Usher syndrome 1D/F;Pituitary adenoma 5, multiple types	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.	NA	NA	NA	PE1	10
+NX_Q9H252	Potassium voltage-gated channel subfamily H member 6	994	109925	6.55	6	Membrane	NA	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly.	NA	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily.	Voltage gated Potassium channels	PE1	17
+NX_Q9H254	Spectrin beta chain, non-erythrocytic 4	2564	288985	5.72	0	Nucleoplasm;Cell cortex;Nucleolus;Cytoskeleton	Neurodevelopmental disorder with hypotonia, neuropathy, and deafness	NA	NA	Belongs to the spectrin family.	RAF/MAP kinase cascade;Interaction between L1 and Ankyrins;NCAM signaling for neurite out-growth;COPI-mediated anterograde transport	PE1	19
+NX_Q9H255	Olfactory receptor 51E2	320	35493	9.16	7	Early endosome membrane;Cell membrane	NA	Olfactory receptor (PubMed:29249973, PubMed:27226631). Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:29249973, PubMed:27226631, PubMed:19389702). The activity of this receptor is propably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973). Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). Activated by L-lactate in glomus cells (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE1	11
+NX_Q9H257	Caspase recruitment domain-containing protein 9	536	62241	5.79	0	Cytoplasm	Candidiasis, familial, 2	Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.	Phosphorylated at Thr-531 and Thr-533 by CK2 following interaction with VHL, leading to inhibit the ability to activate NF-kappa-B.	NA	NOD-like receptor signaling pathway;Tuberculosis;CLEC7A (Dectin-1) signaling;NOD1/2 Signaling Pathway	PE1	9
+NX_Q9H267	Vacuolar protein sorting-associated protein 33B	617	70585	6.29	0	Clathrin-coated vesicle;Recycling endosome;Early endosome;Lysosome membrane;Late endosome membrane	Arthrogryposis, renal dysfunction and cholestasis syndrome 1	May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity).	Phosphorylated on tyrosine residues. Dephosphorylation by M.tuberculosis PtpA is necessary to induce the reduction of host phagolysosome fusion in M.tuberculosis-infected macrophages.	Belongs to the STXBP/unc-18/SEC1 family.	NA	PE1	15
+NX_Q9H269	Vacuolar protein sorting-associated protein 16 homolog	839	94694	6.32	0	Clathrin-coated vesicle;Early endosome;Lysosome membrane;Autophagosome;Late endosome membrane	NA	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).	NA	Belongs to the VPS16 family.	NA	PE1	20
+NX_Q9H270	Vacuolar protein sorting-associated protein 11 homolog	941	107837	6.6	0	Clathrin-coated vesicle;Early endosome;Lysosome membrane;Endosome;Autophagosome;Cytoplasmic vesicle;Cytosol;Late endosome membrane	Leukodystrophy, hypomyelinating, 12	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).	NA	Belongs to the VPS11 family.	NA	PE1	11
+NX_Q9H293	Interleukin-25	177	20330	8.73	0	Secreted	NA	Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.	NA	Belongs to the IL-17 family.	Cytokine-cytokine receptor interaction;Interleukin-17 signaling	PE1	14
+NX_Q9H295	Dendritic cell-specific transmembrane protein	470	53393	9.41	6	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endosome;Endoplasmic reticulum membrane;Cell membrane	NA	Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.	Glycosylated.	NA	CREB3 factors activate genes	PE1	8
+NX_Q9H299	SH3 domain-binding glutamic acid-rich-like protein 3	93	10438	4.82	0	Cytoplasm;Nucleus	NA	Could act as a modulator of glutaredoxin biological activity.	NA	Belongs to the SH3BGR family.	NA	PE1	1
+NX_Q9H2A2	2-aminomuconic semialdehyde dehydrogenase	487	53401	6.76	0	Cytoplasm;Centrosome	NA	Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.	NA	Belongs to the aldehyde dehydrogenase family.	Amino-acid degradation; L-kynurenine degradation.;RA biosynthesis pathway	PE1	6
+NX_Q9H2A3	Neurogenin-2	272	28621	7.65	0	Nucleus	NA	Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').	NA	NA	NA	PE2	4
+NX_Q9H2A7	C-X-C motif chemokine 16	254	27579	9.06	1	Golgi apparatus;Cytoplasmic vesicle;Secreted;Cell membrane	NA	Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.	Glycosylated.	Belongs to the intercrine alpha (chemokine CxC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	17
+NX_Q9H2A9	Carbohydrate sulfotransferase 8	424	48834	10.18	1	Golgi apparatus membrane	Peeling skin syndrome 3	Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.	NA	Belongs to the sulfotransferase 2 family.	Reactions specific to the complex N-glycan synthesis pathway	PE1	19
+NX_Q9H2B2	Synaptotagmin-4	425	47958	8.72	1	Cytoplasmic vesicle;Synaptic vesicle membrane;Cell membrane	NA	Synaptotagmin family member which does not bind Ca(2+) (PubMed:23999003) (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).	NA	Belongs to the synaptotagmin family.	NA	PE1	18
+NX_Q9H2B4	Sulfate anion transporter 1	701	75016	8.47	9	Basolateral cell membrane;Cytoskeleton;Cell membrane	Nephrolithiasis, calcium oxalate	Mediates sulfate transport with high affinity (PubMed:12713736). Mediates oxalate transport (PubMed:12713736). Mediates bicarbonate transport (By similarity). Does not accept succinate as cosubstrate (By similarity).	NA	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Transport and synthesis of PAPS;Multifunctional anion exchangers	PE1	4
+NX_Q9H2C0	Gigaxonin	597	67638	5.58	0	Cytoplasm;Cytoskeleton	Giant axonal neuropathy 1, autosomal recessive	Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.	Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	16
+NX_Q9H2C1	LIM/homeobox protein Lhx5	402	44406	7.87	0	Nucleus	NA	Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.	NA	NA	NA	PE1	12
+NX_Q9H2C2	Protein ARV1	271	31052	8.59	3	Cytoplasmic vesicle;Endoplasmic reticulum membrane	Epileptic encephalopathy, early infantile, 38	Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:11063737, PubMed:12145310, PubMed:20663892). Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892).	NA	Belongs to the ARV1 family.	Cholesterol biosynthesis	PE1	1
+NX_Q9H2C5	Olfactory receptor 52A5	316	35955	9.02	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9H2C8	Olfactory receptor 51V1	321	36749	8.95	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9H2D1	Mitochondrial folate transporter/carrier	315	35407	9.49	6	Mitochondrion inner membrane;Mitochondrion	Exercise intolerance, riboflavin-responsive	Transports folate across the inner membranes of mitochondria.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Metabolism of folate and pterines	PE1	8
+NX_Q9H2D6	TRIO and F-actin-binding protein	2365	261376	8.86	0	Midbody;Centrosome;Nucleus;Cytoskeleton	Deafness, autosomal recessive, 28	May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.	Ubiquitinated by HECTD3, leading to its degradation by the proteasome.;Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.	NA	NA	PE1	22
+NX_Q9H2E6	Semaphorin-6A	1030	114395	8.68	1	Nucleoplasm;Cell membrane;Nucleus;Cytoskeleton	NA	Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity).	NA	Belongs to the semaphorin family.	Axon guidance;Other semaphorin interactions	PE1	5
+NX_Q9H2F3	3 beta-hydroxysteroid dehydrogenase type 7	369	41016	8.48	2	Endoplasmic reticulum membrane;Lipid droplet	Congenital bile acid synthesis defect 1	The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.	NA	Belongs to the 3-beta-HSD family.	Lipid metabolism; steroid biosynthesis.;Primary bile acid biosynthesis;Metabolic pathways;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol	PE1	16
+NX_Q9H2F5	Enhancer of polycomb homolog 1	836	93463	8.77	0	Nucleoplasm;Nucleus	NA	Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.	NA	Belongs to the enhancer of polycomb family.	HATs acetylate histones;Transcriptional Regulation by E2F6	PE1	10
+NX_Q9H2F9	Coiled-coil domain-containing protein 68	335	38869	8.78	0	Golgi apparatus;Cytosol;Centriole	NA	Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092).	NA	NA	NA	PE1	18
+NX_Q9H2G2	STE20-like serine/threonine-protein kinase	1235	142695	5.08	0	Cytoplasm;Cytosol;Cell membrane	NA	Mediates apoptosis and actin stress fiber dissolution.	Autophosphorylated.;Proteolytically cleaved by caspase-3.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	Oocyte meiosis	PE1	10
+NX_Q9H2G4	Testis-specific Y-encoded-like protein 2	693	79435	4.45	0	Cytoplasm;Nucleus	NA	Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.	Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.	Belongs to the nucleosome assembly protein (NAP) family.	XBP1(S) activates chaperone genes	PE1	X
+NX_Q9H2G9	Golgin-45	400	44910	8.74	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Golgi apparatus membrane;Nucleus	NA	Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface.	ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.;Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation.	NA	Golgi Cisternae Pericentriolar Stack Reorganization	PE1	1
+NX_Q9H2H0	CXXC-type zinc finger protein 4	198	20978	9.39	0	Cytoplasm	NA	Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.	NA	NA	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	PE1	4
+NX_Q9H2H8	Peptidyl-prolyl cis-trans isomerase-like 3	161	18155	6.29	0	Nucleoplasm	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.	NA	Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.	mRNA Splicing - Major Pathway	PE1	2
+NX_Q9H2H9	Sodium-coupled neutral amino acid transporter 1	487	54048	6.6	11	Cell membrane	NA	Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.	NA	Belongs to the amino acid/polyamine transporter 2 family.	Glutamatergic synapse;GABAergic synapse;Amino acid transport across the plasma membrane;Astrocytic Glutamate-Glutamine Uptake And Metabolism	PE1	12
+NX_Q9H2I8	Leucine-rich melanocyte differentiation-associated protein	198	22568	6.23	0	Nucleoplasm;Cytosol	Albinism, oculocutaneous, 7	Required for melanocyte differentiation.	NA	NA	NA	PE1	10
+NX_Q9H2J1	Uncharacterized protein ARRDC1-AS1	176	18048	7.75	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_Q9H2J4	Phosducin-like protein 3	239	27614	4.78	0	Cytoplasm;Endoplasmic reticulum;Nucleoplasm;Cytosol;Perinuclear region	NA	Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430).	N-terminal methionine acetylation destabilizes the protein.	Belongs to the phosducin family.	NA	PE1	2
+NX_Q9H2J7	Sodium-dependent neutral amino acid transporter B(0)AT2	730	81836	5.06	12	Membrane;Cytoplasmic vesicle;Nucleolus	NA	Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.	Amino acid transport across the plasma membrane;Na+/Cl- dependent neurotransmitter transporters	PE1	12
+NX_Q9H2K0	Translation initiation factor IF-3, mitochondrial	278	31725	9.7	0	Nucleoplasm;Mitochondrion	NA	IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.	NA	Belongs to the IF-3 family.	Mitochondrial translation initiation	PE1	13
+NX_Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	1166	126918	6.76	0	Cytoplasm;Telomere;Golgi apparatus membrane;Nucleus;Cytoskeleton	NA	Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245).	Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation.;ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.;The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.	NA	Degradation of AXIN;TCF dependent signaling in response to WNT;XAV939 inhibits tankyrase, stabilizing AXIN;Ub-specific processing proteases;Regulation of PTEN stability and activity	PE1	10
+NX_Q9H2K8	Serine/threonine-protein kinase TAO3	898	105406	6.83	0	Cytoplasm;Mitochondrion;Cell membrane	NA	Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).	Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2.;TAOK3 is phosphorylated by LRRK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	MAPK signaling pathway	PE1	12
+NX_Q9H2L4	Transmembrane protein 60	133	15500	9.62	4	Membrane	NA	NA	NA	NA	NA	PE2	7
+NX_Q9H2L5	Ras association domain-containing protein 4	321	36748	7.66	0	Nucleoplasm;Cell junction;Nucleolus	NA	Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.	NA	NA	NA	PE1	10
+NX_Q9H2M3	S-methylmethionine--homocysteine S-methyltransferase BHMT2	363	40354	5.61	0	NA	NA	Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.	NA	NA	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.;Sulfur amino acid metabolism	PE1	5
+NX_Q9H2M9	Rab3 GTPase-activating protein non-catalytic subunit	1393	155985	5.4	0	Cytoplasm;Cytosol;Cell membrane	Martsolf syndrome;Warburg micro syndrome 2	Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.	NA	Belongs to the Rab3-GAP regulatory subunit family.	COPI-independent Golgi-to-ER retrograde traffic;RAB GEFs exchange GTP for GDP on RABs	PE1	1
+NX_Q9H2P0	Activity-dependent neuroprotector homeobox protein	1102	123563	6.97	0	Nucleoplasm;Nucleus	Helsmoortel-van der Aa syndrome	Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.	NA	NA	NA	PE1	20
+NX_Q9H2P9	Diphthine methyl ester synthase	285	31651	5.19	0	Golgi apparatus	NA	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.	NA	Belongs to the diphthine synthase family.	Protein modification; peptidyl-diphthamide biosynthesis.;Synthesis of diphthamide-EEF2	PE1	1
+NX_Q9H2R5	Kallikrein-15	256	28087	8.27	0	Secreted	NA	Protease whose physiological substrate is not yet known.	NA	Belongs to the peptidase S1 family. Kallikrein subfamily.	NA	PE1	19
+NX_Q9H2S1	Small conductance calcium-activated potassium channel protein 2	579	63760	9.58	6	Membrane;Nucleoplasm;Cytosol	NA	Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.	NA	Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.	Bile secretion;Ca2+ activated K+ channels	PE1	5
+NX_Q9H2S5	RING finger protein 39	420	45525	8.69	0	Cytoplasmic vesicle;Cytoplasm;Centrosome;Cell membrane	NA	May play a role in prolonged long term-potentiation (LTP) maintenance.	NA	NA	NA	PE1	6
+NX_Q9H2S6	Tenomodulin	317	37130	5.12	1	Membrane;Cytoplasm;Nucleus envelope	NA	May be an angiogenesis inhibitor.	NA	Belongs to the chondromodulin-1 family.	NA	PE1	X
+NX_Q9H2S9	Zinc finger protein Eos	585	64106	6.39	0	Nucleoplasm;Nucleus	NA	DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).	NA	Belongs to the Ikaros C2H2-type zinc-finger protein family.	NA	PE1	12
+NX_Q9H2T7	Ran-binding protein 17	1088	124375	6.02	0	Cytoplasm;Nuclear pore complex;Nucleus membrane;Cytosol;Nucleus	NA	May function as a nuclear transport receptor.	NA	Belongs to the exportin family.	NA	PE1	5
+NX_Q9H2U1	ATP-dependent DNA/RNA helicase DHX36	1008	114760	7.58	0	Cytoplasm;Stress granule;Mitochondrion;Nucleus speckle;Perikaryon;Nucleoplasm;Telomere;Cytosol;Axon;Dendrite;Nucleus	NA	Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity).	NA	Belongs to the DEAD box helicase family. DEAH subfamily.	RNA degradation;DEx/H-box helicases activate type I IFN and inflammatory cytokines production	PE1	3
+NX_Q9H2U2	Inorganic pyrophosphatase 2, mitochondrial	334	37920	7.07	0	Nucleoplasm;Mitochondrion	Sudden cardiac failure, alcohol-induced;Sudden cardiac failure, infantile	Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598).	NA	Belongs to the PPase family.	Oxidative phosphorylation;Mitochondrial tRNA aminoacylation;Pyrophosphate hydrolysis	PE1	4
+NX_Q9H2U6	Putative uncharacterized protein encoded by LINC00597	94	11474	7.64	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_Q9H2U9	Disintegrin and metalloproteinase domain-containing protein 7	754	85669	6.08	1	Membrane	NA	May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).	NA	NA	NA	PE1	8
+NX_Q9H2V7	Protein spinster homolog 1	528	56630	6.19	12	Golgi apparatus;Nucleolus;Endoplasmic reticulum;Endosome;Cytoplasmic vesicle;Cytosol;Mitochondrion inner membrane	NA	Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death.	NA	Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.	NA	PE1	16
+NX_Q9H2W1	Membrane-spanning 4-domains subfamily A member 6A	248	26943	6.57	4	Membrane	NA	May be involved in signal transduction as a component of a multimeric receptor complex.	NA	Belongs to the MS4A family.	NA	PE1	11
+NX_Q9H2W2	Homeobox protein MIXL1	232	24659	9.04	0	Nucleoplasm;Nucleus	NA	Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity).	Phosphorylated at multiple sites.	Belongs to the paired homeobox family.	NA	PE1	1
+NX_Q9H2W6	39S ribosomal protein L46, mitochondrial	279	31705	6.55	0	Nucleoplasm;Cell junction;Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL46 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	15
+NX_Q9H2X0	Chordin	955	102032	8.07	0	Secreted	NA	Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).	Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.	Belongs to the chordin family.	TGF-beta signaling pathway	PE1	3
+NX_Q9H2X3	C-type lectin domain family 4 member M	399	45350	5.12	1	Secreted;Cell membrane	NA	Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.;(Microbial infection) Acts as an attachment receptor for Ebolavirus.;(Microbial infection) Acts as an attachment receptor for HIV-1.;(Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.;(Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.;(Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.;(Microbial infection) Acts as an attachment receptor for Influenzavirus.;(Microbial infection) Acts as an attachment receptor for SARS coronavirus.;(Microbial infection) Acts as an attachment receptor for Hepatitis C virus.;(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.;(Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.;(Microbial infection) Acts as an attachment receptor for West-nile virus.	NA	NA	Phagosome;Tuberculosis;Measles	PE1	19
+NX_Q9H2X6	Homeodomain-interacting protein kinase 2	1198	130966	8.69	0	Nucleoplasm;Cytoplasm;PML body	NA	Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.	Autophosphorylation at Tyr-361 in the activation loop activates the kinase and promotes nuclear localization.;Sumoylated. When conjugated it is directed to nuclear speckles. Desumoylated by SENP1 (By similarity). Sumoylation on Lys-32 is promoted by the E3 SUMO-protein ligase CBX4.;Ubiquitinated by FBXO3, WSB1 and SIAH1, leading to rapid proteasome-dependent degradation. The degradation mediated by FBXO3, but not ubiquitination, is prevented in the presence of PML. The degradation mediated by WSB1 and SIAH1 is reversibly reduced upon DNA damage.;Cleaved at Asp-923 and Asp-984 by CASP6 in a p53/TP53-dependent manner. The cleaved form lacks the autoinhibitory C-terminal domain (AID), resulting in a hyperactive kinase, which potentiates p53/TP53 Ser-46 phosphorylation and subsequent activation of the cell death machinery.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);HIPK2 is phosphorylated by MAP3K7 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.	YAP1- and WWTR1 (TAZ)-stimulated gene expression;Physiological factors;Regulation of TP53 Activity through Phosphorylation;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;SUMOylation of transcription cofactors;Regulation of MECP2 expression and activity	PE1	7
+NX_Q9H2X8	Interferon alpha-inducible protein 27-like protein 2	130	12410	5.36	3	Mitochondrion membrane;Cytosol;Nucleolus	NA	Plays a role in the apoptotic process and has a pro-apoptotic activity.	NA	Belongs to the IFI6/IFI27 family.	NA	PE1	14
+NX_Q9H2X9	Solute carrier family 12 member 5	1139	126184	6.29	12	Membrane	Epilepsy, idiopathic generalized 14;Epileptic encephalopathy, early infantile, 34	Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262).	NA	Belongs to the SLC12A transporter family.	GABAergic synapse;Cation-coupled Chloride cotransporters	PE1	20
+NX_Q9H2Y7	Zinc finger protein 106	1883	208883	6.73	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleolus	NA	RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism.	Phosphorylated by FYN in vitro.	NA	NA	PE1	15
+NX_Q9H2Y9	Solute carrier organic anion transporter family member 5A1	848	91864	7.96	12	Cytoplasmic vesicle;Cell membrane	NA	NA	NA	Belongs to the organo anion transporter (TC 2.A.60) family.	NA	PE2	8
+NX_Q9H2Z4	Homeobox protein Nkx-2.4	354	36179	9.6	0	Nucleus	NA	Probable transcription factor.	NA	Belongs to the NK-2 homeobox family.	NA	PE1	20
+NX_Q9H300	Presenilins-associated rhomboid-like protein, mitochondrial	379	42190	9.82	7	Mitochondrion inner membrane;Mitochondrion;Nucleus	NA	Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.	P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated.	Belongs to the peptidase S54 family.	Processing of SMDT1	PE1	3
+NX_Q9H305	Cell death-inducing p53-target protein 1	208	21892	5.55	0	Nucleoplasm;Lysosome membrane;Centrosome;Late endosome membrane	NA	Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.	NA	Belongs to the CDIP1/LITAF family.	NA	PE1	16
+NX_Q9H306	Matrix metalloproteinase-27	513	59026	8.83	0	Endoplasmic reticulum membrane	NA	Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.	N-glycosylated.	Belongs to the peptidase M10A family.	NA	PE1	11
+NX_Q9H307	Pinin	717	81628	6.71	0	Nucleus speckle;Desmosome	NA	Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.	NA	Belongs to the pinin family.	RNA transport;mRNA surveillance pathway	PE1	14
+NX_Q9H310	Ammonium transporter Rh type B	441	47231	8.74	12	Basolateral cell membrane;Nucleoplasm;Cytoplasmic vesicle membrane	NA	Functions as a specific ammonium transporter.	N-glycosylated.	Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.	Rhesus glycoproteins mediate ammonium transport	PE1	1
+NX_Q9H313	Protein tweety homolog 1	450	49051	4.88	5	Cell membrane	NA	May be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in regulation of cell volume.;Probable chloride channel. May be involved in cell adhesion (By similarity).	NA	Belongs to the tweety family.	Stimuli-sensing channels	PE1	19
+NX_Q9H320	Variable charge X-linked protein 1	206	22289	4.37	0	NA	NA	May mediate a process in spermatogenesis or may play a role in sex ratio distortion.	NA	Belongs to the VCX/VCY family.	NA	PE2	X
+NX_Q9H321	Variable charge X-linked protein 3B	246	26878	4.2	0	NA	NA	May mediate a process in spermatogenesis or may play a role in sex ratio distortion.	NA	Belongs to the VCX/VCY family.	NA	PE2	X
+NX_Q9H322	Variable charge X-linked protein 2	139	14661	6.18	0	NA	NA	May mediate a process in spermatogenesis or may play a role in sex ratio distortion.	NA	Belongs to the VCX/VCY family.	NA	PE2	X
+NX_Q9H324	A disintegrin and metalloproteinase with thrombospondin motifs 10	1103	120874	8.34	0	Extracellular matrix	Weill-Marchesani syndrome 1	Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.	Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	19
+NX_Q9H329	Band 4.1-like protein 4B	900	99712	9.17	0	Cytoplasm;Cytosol;Tight junction;Cell membrane	NA	Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927).	May be negatively regulated by phosphorylation.	NA	NA	PE1	9
+NX_Q9H330	Transmembrane protein 245	879	97357	9.04	14	Membrane;Cytosol;Cell membrane	NA	NA	NA	Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.	NA	PE1	9
+NX_Q9H334	Forkhead box protein P1	677	75317	6.2	0	Nucleoplasm;Nucleus	Mental retardation with language impairment and autistic features	Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity).;Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).	NA	NA	Transcriptional regulation of pluripotent stem cells	PE1	3
+NX_Q9H336	Cysteine-rich secretory protein LCCL domain-containing 1	500	56888	8.47	0	Secreted	NA	NA	NA	Belongs to the CRISP family.	NA	PE1	8
+NX_Q9H339	Olfactory receptor 51B5	312	35241	8.59	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9H340	Olfactory receptor 51B6	312	35269	9.26	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	11
+NX_Q9H341	Olfactory receptor 51M1	326	36669	9.1	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_Q9H342	Olfactory receptor 51J1	316	34838	8.5	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory Signaling Pathway	PE3	11
+NX_Q9H343	Olfactory receptor 51I1	314	35484	9.22	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9H344	Olfactory receptor 51I2	312	35002	8.98	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9H346	Olfactory receptor 52D1	318	35122	8.57	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9H347	Ubiquilin-3	655	70841	5.01	0	NA	NA	NA	NA	NA	Protein processing in endoplasmic reticulum	PE1	11
+NX_Q9H354	Putative uncharacterized protein PRO1933	126	14747	10.34	1	Membrane	NA	NA	NA	NA	NA	PE5	10
+NX_Q9H361	Polyadenylate-binding protein 3	631	70031	9.68	0	Cytoplasm	NA	Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.	NA	Belongs to the polyadenylate-binding protein type-1 family.	RNA transport;mRNA surveillance pathway;RNA degradation	PE1	13
+NX_Q9H379	Putative uncharacterized protein PRO3102	93	10324	7.47	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_Q9H3C7	Gametogenetin-binding protein 2	697	79086	5.97	0	Endoplasmic reticulum;Cytoplasmic vesicle	NA	May be involved in spermatogenesis.	NA	NA	NA	PE1	17
+NX_Q9H3D4	Tumor protein 63	680	76785	6.12	0	Nucleoplasm;Nucleus	Ankyloblepharon-ectodermal defects-cleft lip/palate;Acro-dermato-ungual-lacrimal-tooth syndrome;Orofacial cleft 8;Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3;Rapp-Hodgkin syndrome;Limb-mammary syndrome;Split-hand/foot malformation 4	Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity.;Activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.	Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.;May be sumoylated.	Belongs to the p53 family.	TP53 Regulates Metabolic Genes;Activation of PUMA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of Death Receptors and Ligands;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;TP53 Regulates Transcription of Caspase Activators and Caspases;Regulation of TP53 Activity through Association with Co-factors	PE1	3
+NX_Q9H3E2	Sorting nexin-25	840	97945	5.99	0	Cytoplasmic vesicle;Endosome membrane	NA	May be involved in several stages of intracellular trafficking.	NA	Belongs to the sorting nexin family.	NA	PE1	4
+NX_Q9H3F6	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3	313	35432	5.97	0	Nucleoplasm;Cytosol;Nucleus	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).	NA	Belongs to the BACURD family.	Protein modification; protein ubiquitination.	PE1	12
+NX_Q9H3G5	Probable serine carboxypeptidase CPVL	476	54164	5.39	0	Endoplasmic reticulum	NA	May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.	NA	Belongs to the peptidase S10 family.	NA	PE1	7
+NX_Q9H3H1	tRNA dimethylallyltransferase	467	52725	8.35	0	Nucleoplasm;Cytoplasm;Cytosol;Mitochondrion	Combined oxidative phosphorylation deficiency 35	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).	NA	Belongs to the IPP transferase family.	Metabolic pathways;tRNA modification in the nucleus and cytosol;tRNA modification in the mitochondrion	PE1	1
+NX_Q9H3H3	UPF0696 protein C11orf68	292	31430	5.92	0	Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the UPF0696 family.	NA	PE1	11
+NX_Q9H3H5	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	408	46090	8.25	10	Endoplasmic reticulum membrane	Congenital disorder of glycosylation 1J;Myasthenic syndrome, congenital, 13	Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.	NA	Belongs to the glycosyltransferase 4 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2	PE1	11
+NX_Q9H3H9	Transcription elongation factor A protein-like 2	227	25850	5.79	0	Cytosol;Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the TFS-II family. TFA subfamily.	NA	PE1	X
+NX_Q9H3J6	Probable peptide chain release factor C12orf65, mitochondrial	166	18828	9.82	0	Nucleoplasm;Cytosol;Mitochondrion	Spastic paraplegia 55, autosomal recessive;Combined oxidative phosphorylation deficiency 7	May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion. May help rescuing stalled mitoribosomes during translation (By similarity).	NA	Belongs to the prokaryotic/mitochondrial release factor family.	NA	PE1	12
+NX_Q9H3K2	Growth hormone-inducible transmembrane protein	345	37205	9.95	7	Mitochondrion inner membrane;Mitochondrion	NA	Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.	NA	Belongs to the BI1 family.	NA	PE1	10
+NX_Q9H3K6	BolA-like protein 2	86	10117	6.07	0	Cytoplasm;Nucleus	NA	Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415).	NA	Belongs to the BolA/IbaG family.	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	PE1	16
+NX_Q9H3L0	Methylmalonic aciduria and homocystinuria type D protein, mitochondrial	296	32940	5.16	0	Cytoplasm;Mitochondrion	Methylmalonic aciduria and homocystinuria, cblD type	Involved in cobalamin metabolism (PubMed:18385497, PubMed:23415655, PubMed:24722857, PubMed:26364851). Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin (PubMed:18385497, PubMed:24722857). Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin (PubMed:23415655, PubMed:24722857). Promotes oxidation of cob(II)alamin bound to MMACHC (PubMed:26364851).	NA	NA	Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD	PE1	2
+NX_Q9H3M0	Potassium voltage-gated channel subfamily F member 1	494	55584	5.9	6	Membrane;Golgi apparatus	NA	Putative voltage-gated potassium channel.	NA	Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily.	Voltage gated Potassium channels	PE1	2
+NX_Q9H3M7	Thioredoxin-interacting protein	391	43661	7.46	0	Cytoplasm;Cytosol;Cell membrane	NA	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).	Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.	Belongs to the arrestin family.	The NLRP3 inflammasome;Regulation of FOXO transcriptional activity by acetylation	PE1	1
+NX_Q9H3M9	Ataxin-3-like protein	355	40747	4.87	0	Nucleus	NA	Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro).	NA	NA	Protein processing in endoplasmic reticulum;Josephin domain DUBs	PE1	X
+NX_Q9H3N1	Thioredoxin-related transmembrane protein 1	280	31791	4.91	1	Membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane;Nucleolus	NA	May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.	NA	NA	NA	PE1	14
+NX_Q9H3N8	Histamine H4 receptor	390	44496	9.62	7	Cell membrane	NA	The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Histamine receptors	PE1	18
+NX_Q9H3P2	Negative elongation factor A	528	57277	9.1	0	Nucleoplasm;Nucleus	NA	(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.;Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.	NA	Belongs to the NELF-A family.	Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes	PE1	4
+NX_Q9H3P7	Golgi resident protein GCP60	528	60593	5.02	0	Golgi apparatus;Mitochondrion;Golgi apparatus membrane	NA	Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356).;(Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites.	NA	NA	Golgi Associated Vesicle Biogenesis	PE1	1
+NX_Q9H3Q1	Cdc42 effector protein 4	356	37980	5.05	0	Endomembrane system;Cell membrane;Cytoskeleton	NA	Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.	CDC42EP4 is phosphorylated by MAPK3	Belongs to the BORG/CEP family.	NA	PE1	17
+NX_Q9H3Q3	Galactose-3-O-sulfotransferase 2	398	46110	10.03	1	Golgi stack membrane	NA	Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.	NA	Belongs to the galactose-3-O-sulfotransferase family.	Protein modification; carbohydrate sulfation.	PE1	2
+NX_Q9H3R0	Lysine-specific demethylase 4C	1056	119982	6.06	0	Nucleoplasm;Nucleus	NA	Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.	NA	Belongs to the JHDM3 histone demethylase family.	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;HDMs demethylate histones	PE1	9
+NX_Q9H3R1	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4	872	100716	7.19	1	Golgi apparatus membrane	NA	Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).	NA	Belongs to the sulfotransferase 1 family. NDST subfamily.	Glycan metabolism; heparin biosynthesis.;Glycan metabolism; heparan sulfate biosynthesis.;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;HS-GAG biosynthesis	PE1	4
+NX_Q9H3R2	Mucin-13	512	54604	4.91	1	Apical cell membrane;Secreted;Cell membrane	NA	Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.	Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homooligomerization into dimers is dependent on intrachain disulfide bonds.;Highly N-glycosylated.	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	3
+NX_Q9H3R5	Centromere protein H	247	28481	5.23	0	Kinetochore;Nucleoplasm;Nucleolus;Nucleus	NA	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.	NA	Belongs to the CENP-H/MCM16 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	5
+NX_Q9H3S1	Semaphorin-4A	761	83574	6.38	1	Cell membrane	Cone-rod dystrophy 10;Retinitis pigmentosa 35	Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).	NA	Belongs to the semaphorin family.	Axon guidance;Other semaphorin interactions	PE1	1
+NX_Q9H3S3	Transmembrane protease serine 5	457	49560	6.24	1	Nucleoplasm;Cell membrane	NA	May play a role in hearing.	NA	Belongs to the peptidase S1 family.	NA	PE1	11
+NX_Q9H3S4	Thiamin pyrophosphokinase 1	243	27265	5.03	0	Cytoplasmic vesicle	Thiamine metabolism dysfunction syndrome 5, episodic encephalopathy type	Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.	NA	Belongs to the thiamine pyrophosphokinase family.	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.;Thiamine metabolism;Metabolic pathways;Vitamin B1 (thiamin) metabolism	PE1	7
+NX_Q9H3S5	GPI mannosyltransferase 1	423	49460	9.26	10	Endoplasmic reticulum membrane	Glycosylphosphatidylinositol deficiency	Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.	NA	Belongs to the PIGM family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	1
+NX_Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	1636	178974	6.45	0	Cytoplasm;Early endosome;Cilium basal body;Nucleoplasm;Endosome;Cytoplasmic vesicle;Nucleus	NA	Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.	Interleukin-37 signaling	PE1	3
+NX_Q9H3T2	Semaphorin-6C	930	99686	8.36	1	Nucleoplasm;Cytosol;Nucleolus;Cell membrane	NA	Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.	NA	Belongs to the semaphorin family.	Axon guidance	PE1	1
+NX_Q9H3T3	Semaphorin-6B	888	95285	8.83	1	Cell membrane	NA	May play a role in both peripheral and central nervous system development.	NA	Belongs to the semaphorin family.	Axon guidance	PE1	19
+NX_Q9H3U1	Protein unc-45 homolog A	944	103077	5.8	0	Cytoplasm;Nucleus speckle;Cytosol;Perinuclear region;Nucleus	NA	Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).	NA	NA	NA	PE1	15
+NX_Q9H3U5	Major facilitator superfamily domain-containing protein 1	465	51209	6.32	11	Membrane;Endoplasmic reticulum;Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the major facilitator superfamily.	NA	PE1	3
+NX_Q9H3U7	SPARC-related modular calcium-binding protein 2	446	49674	8.8	0	Basement membrane	Dentin dysplasia 1	Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.	NA	NA	NA	PE1	6
+NX_Q9H3V2	Membrane-spanning 4-domains subfamily A member 5	200	22283	6.27	4	Membrane	NA	May be involved in signal transduction as a component of a multimeric receptor complex.	NA	Belongs to the MS4A family.	NA	PE2	11
+NX_Q9H3W5	Leucine-rich repeat neuronal protein 3	708	79424	8.02	1	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	7
+NX_Q9H3Y0	Peptidase inhibitor R3HDML	253	28605	9.25	0	Secreted	NA	Putative serine protease inhibitor.	NA	Belongs to the CRISP family.	NA	PE2	20
+NX_Q9H3Y6	Tyrosine-protein kinase Srms	488	54507	8.51	0	Cytoplasm;Cytosol;Cytoskeleton	NA	Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907).	NA	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.	PTK6 Down-Regulation	PE1	20
+NX_Q9H3Y8	Pancreatic progenitor cell differentiation and proliferation factor	114	11777	6.89	0	Nucleoplasm;Nucleolus;Cytoskeleton	NA	Probable regulator of exocrine pancreas development.	NA	Belongs to the PPDPF family.	NA	PE1	20
+NX_Q9H3Z4	DnaJ homolog subfamily C member 5	198	22149	4.93	0	Membrane;Golgi apparatus;Melanosome;Cell membrane	Ceroid lipofuscinosis, neuronal, 4B	Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).	Ser-10 phosphorylation induces an order-to-disorder transition triggering the interaction with Lys-58 (PubMed:27452402). This conformational switch modulates DNAJC5's cellular functions by reducing binding to syntaxin and synaptogamin without altering HSC70 interactions (PubMed:27452402).;Fatty acylated (By similarity). Heavily palmitoylated in the cysteine string motif (By similarity).;DNAJC5 is phosphorylated by PRKACA	NA	Protein processing in endoplasmic reticulum;GABA synthesis, release, reuptake and degradation;Neutrophil degranulation	PE1	20
+NX_Q9H3Z7	Protein ABHD16B	469	52555	8.9	0	Nucleoplasm	NA	NA	NA	Belongs to the AB hydrolase superfamily. ABHD16 family.	NA	PE1	20
+NX_Q9H400	Lck-interacting transmembrane adapter 1	295	31288	9.7	1	Cell membrane	NA	Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.	Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation; which leads to the recruitment of SH2-containing proteins.;Palmitoylation of Cys-28 and Cys-31 is required for raft targeting.;LIME1 is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	NA	NA	PE1	20
+NX_Q9H410	Kinetochore-associated protein DSN1 homolog	356	40067	6.57	0	Nucleolus;Nucleoplasm;Cytosol;Nucleus;Kinetochore	NA	Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.	NA	NA	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Neutrophil degranulation	PE1	20
+NX_Q9H422	Homeodomain-interacting protein kinase 3	1215	133743	7.16	0	Cytoplasm;Cytosol;Nucleus	NA	Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).	May be sumoylated.;Autophosphorylated, but autophosphorylation is not required for catalytic activity.;Autophosphorylated	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.	NA	PE1	11
+NX_Q9H425	Uncharacterized protein C1orf198	327	36346	5.6	0	Cytoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q9H426	Regulating synaptic membrane exocytosis protein 4	269	29329	5.65	0	Nucleoplasm;Synapse	NA	Regulates synaptic membrane exocytosis.	NA	NA	NA	PE1	20
+NX_Q9H427	Potassium channel subfamily K member 15	330	36130	9.89	4	Membrane	NA	Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.	NA	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Phase 4 - resting membrane potential	PE1	20
+NX_Q9H444	Charged multivesicular body protein 4b	224	24950	4.76	0	Cytosol;Nucleus envelope;Midbody;Late endosome membrane	Cataract 31, multiple types	(Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.;Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).	ISGylated. Isgylation weakens its interaction with VPS4A.	Belongs to the SNF7 family.	Endocytosis;Macroautophagy;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	20
+NX_Q9H446	RWD domain-containing protein 1	243	27940	4.11	0	NA	NA	Protects DRG2 from proteolytic degradation.	NA	Belongs to the RWDD1/GIR2 family.	NA	PE1	6
+NX_Q9H461	Frizzled-8	694	73300	8.58	7	Membrane;Golgi apparatus;Endoplasmic reticulum;Cell membrane	NA	Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.	Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Asymmetric localization of PCP proteins;Class B/2 (Secretin family receptors);Regulation of FZD by ubiquitination;RNF mutants show enhanced WNT signaling and proliferation	PE1	10
+NX_Q9H467	CUE domain-containing protein 2	287	32009	4.74	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.	NA	Belongs to the CUEDC2 family.	NA	PE1	10
+NX_Q9H469	F-box/LRR-repeat protein 15	300	32998	7.13	0	Cytoplasm	NA	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.	NA	Belongs to the FBXL15 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	10
+NX_Q9H477	Ribokinase	322	34143	4.94	0	Cytoplasm;Cytosol;Nucleus	NA	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.	NA	Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.	Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.;Pentose phosphate pathway;Pentose phosphate pathway	PE1	2
+NX_Q9H478	KCNQ1 downstream neighbor protein	68	7384	9.59	0	NA	NA	NA	NA	NA	NA	PE2	11
+NX_Q9H479	Fructosamine-3-kinase	309	35171	7.13	0	Mitochondrion	NA	Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848).	NA	Belongs to the fructosamine kinase family.	Gamma carboxylation, hypusine formation and arylsulfatase activation	PE1	17
+NX_Q9H488	GDP-fucose protein O-fucosyltransferase 1	388	43956	8.77	0	Endoplasmic reticulum;Centrosome	Dowling-Degos disease 2	Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).	N-glycosylated.	Belongs to the glycosyltransferase 65 family.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;Pre-NOTCH Processing in the Endoplasmic Reticulum	PE1	20
+NX_Q9H489	Putative testis-specific Y-encoded-like protein 3	355	39573	8.24	0	NA	NA	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE5	20
+NX_Q9H490	Phosphatidylinositol glycan anchor biosynthesis class U protein	435	50052	7.59	9	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane	NA	Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.	NA	Belongs to the PIGU family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Attachment of GPI anchor to uPAR	PE1	20
+NX_Q9H492	Microtubule-associated proteins 1A/1B light chain 3A	121	14272	8.73	0	Autophagosome membrane;Endomembrane system;Autophagosome;Cytoskeleton	NA	Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). Through its interaction with the reticulophagy receptor TEX264, paticipates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).	Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.;The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).;The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.	Belongs to the ATG8 family.	Macroautophagy;Pink/Parkin Mediated Mitophagy;Receptor Mediated Mitophagy	PE1	20
+NX_Q9H496	Torsin-1A-interacting protein 2, isoform IFRG15	131	15348	6.88	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q9H497	Torsin-3A	397	46199	5.67	0	Cytoplasm;Endoplasmic reticulum lumen	NA	NA	N-glycosylated.	Belongs to the ClpA/ClpB family. Torsin subfamily.	NA	PE1	1
+NX_Q9H4A3	Serine/threonine-protein kinase WNK1	2382	250794	5.94	0	Cytoplasm;Cytosol	Neuropathy, hereditary sensory and autonomic, 2A;Pseudohypoaldosteronism 2C	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).;Dominant-negative regulator of the longer isoform 1. Does not have kinase activity, does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport. Downregulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity. In kidney, may play an important role regulating sodium and potassium balance.	Ubiquitinated in vitro by the BCR(KLHL3) complex and in vivo by a BCR(KLHL2) complex, leading to proteasomal degradation.;May be O-glycosylated.;Autophosphorylation at Ser-382 is inhibited by intracellular calcium.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.	Stimuli-sensing channels	PE1	12
+NX_Q9H4A4	Aminopeptidase B	650	72596	5.51	0	Golgi apparatus;Nucleoplasm;Secreted	NA	Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity).	NA	Belongs to the peptidase M1 family.	NA	PE1	1
+NX_Q9H4A5	Golgi phosphoprotein 3-like	285	32767	5.62	0	Cell membrane;trans-Golgi network membrane;Golgi stack membrane;Nucleoplasm;Cytosol	NA	Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.	NA	Belongs to the GOLPH3/VPS74 family.	NA	PE1	1
+NX_Q9H4A6	Golgi phosphoprotein 3	298	33811	6.05	0	Golgi apparatus;Cell membrane;trans-Golgi network membrane;Mitochondrion intermembrane space;Golgi stack membrane;Endosome;Cytoplasmic vesicle	NA	Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.	Phosphorylated.	Belongs to the GOLPH3/VPS74 family.	NA	PE1	5
+NX_Q9H4A9	Dipeptidase 2	486	53365	6.08	0	Membrane	NA	Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).	NA	Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.	Aflatoxin activation and detoxification;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	16
+NX_Q9H4B0	Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial	414	45123	8.83	0	Mitochondrion	NA	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.	NA	Belongs to the KAE1 / TsaD family.	NA	PE1	2
+NX_Q9H4B4	Serine/threonine-protein kinase PLK3	646	71629	9.28	0	Golgi apparatus;Cytoplasm;Nucleolus;Centrosome;Nucleus	NA	Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.	Phosphorylated in an ATM-dependent manner following DNA damage. Phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.	Tuberculosis;Regulation of TP53 Activity through Phosphorylation;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	1
+NX_Q9H4B6	Protein salvador homolog 1	383	44634	9.12	0	Cytoplasm;Cytosol;Nucleus	NA	Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.	Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule.;SAV1 is phosphorylated by STK3	NA	Signaling by Hippo	PE1	14
+NX_Q9H4B7	Tubulin beta-1 chain	451	50327	5.05	0	Cytoplasm;Cytoskeleton	Macrothrombocytopenia, autosomal dominant, TUBB1-related	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).	Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Hedgehog 'off' state;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	20
+NX_Q9H4B8	Dipeptidase 3	488	53687	8.11	0	Membrane	NA	Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).	NA	Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.	Aflatoxin activation and detoxification;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	16
+NX_Q9H4D0	Calsyntenin-2	955	107006	5.21	1	Endoplasmic reticulum membrane;Cell membrane;Postsynapse;Golgi apparatus membrane;Cytoplasmic vesicle;Dendrite;Cytoskeleton	NA	May modulate calcium-mediated postsynaptic signals.	Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-gamma chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1 (By similarity).	NA	NA	PE1	3
+NX_Q9H4D5	Nuclear RNA export factor 3	531	60102	6.29	0	Cytoplasm;Nucleoplasm;Nucleus	NA	May function as a tissue-specific nuclear mRNA export factor.	NA	Belongs to the NXF family.	Ribosome biogenesis in eukaryotes;RNA transport;mRNA surveillance pathway;Influenza A;Herpes simplex infection	PE1	X
+NX_Q9H4E5	Rho-related GTP-binding protein RhoJ	214	23821	6.37	0	Nucleoplasm;Nucleolus;Cell membrane	NA	Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707).	Palmitoylated; regulates localization to the plasma membrane and may be mediated by GLUL.	Belongs to the small GTPase superfamily. Rho family.	Rho GTPase cycle	PE1	14
+NX_Q9H4E7	Differentially expressed in FDCP 6 homolog	631	73910	5.78	0	Cytoplasm;Cell membrane;Nucleoplasm;Filopodium;Perinuclear region;Nucleus;Cytoskeleton	NA	Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).	Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation.	NA	NA	PE1	6
+NX_Q9H4F1	Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase	302	34201	8.9	1	Golgi apparatus;Nucleoplasm;Golgi apparatus membrane	NA	Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).	NA	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Sialic acid metabolism;Termination of O-glycan biosynthesis	PE1	9
+NX_Q9H4F8	SPARC-related modular calcium-binding protein 1	434	48163	8.59	0	Basement membrane;Cell membrane	Ophthalmoacromelic syndrome	Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.	Glycosylated.	NA	NA	PE1	14
+NX_Q9H4G0	Band 4.1-like protein 1	881	98503	5.43	0	Cytoskeleton;Cell membrane	Mental retardation, autosomal dominant 11	May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.	EPB41L1 is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Tight junction;Trafficking of AMPA receptors;Neurexins and neuroligins	PE1	20
+NX_Q9H4G1	Cystatin-9-like	147	17276	5.93	0	Secreted	NA	NA	NA	Belongs to the cystatin family.	NA	PE1	20
+NX_Q9H4G4	Golgi-associated plant pathogenesis-related protein 1	154	17218	9.44	0	Cytoplasmic vesicle;Cytoskeleton;Golgi apparatus membrane	NA	NA	NA	Belongs to the CRISP family.	NA	PE1	9
+NX_Q9H4G8	Putative DPH3 homolog B	78	8721	3.96	0	NA	NA	NA	NA	Belongs to the DPH3 family.	NA	PE5	20
+NX_Q9H4H8	Protein FAM83D	585	64424	6.1	0	Cytoplasm;Spindle pole;Cytosol;Spindle;Cytoskeleton	NA	Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.	Phosphorylated during mitosis.	Belongs to the FAM83 family.	NA	PE1	20
+NX_Q9H4I0	Double-strand-break repair protein rad21-like protein 1	556	63324	5.07	0	Nucleus;Chromosome	NA	Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).	NA	Belongs to the rad21 family.	NA	PE1	20
+NX_Q9H4I2	Zinc fingers and homeoboxes protein 3	956	104658	5.73	0	Nucleoplasm;Nucleus	NA	Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.	NA	Belongs to the ZHX family.	NA	PE1	20
+NX_Q9H4I3	TraB domain-containing protein	376	42321	8.15	0	Nucleoplasm;Mitochondrion	NA	NA	NA	NA	NA	PE1	22
+NX_Q9H4I8	Serine hydrolase-like protein 2	314	35369	6.3	0	Peroxisome;Perinuclear region	NA	Probable serine hydrolase. May be related to cell muscle hypertrophy.	NA	Belongs to the AB hydrolase superfamily.	NA	PE1	22
+NX_Q9H4I9	Essential MCU regulator, mitochondrial	107	11441	6.56	1	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988). Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU (PubMed:24231807). Plays a central role in regulating the uniplex complex response to intracellular calcium signaling (PubMed:27099988). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988).	Undergoes proteolytic degradation in neurons: degraded by AFG3L2 before SMDT1/EMRE assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048).	Belongs to the SMDT1/EMRE family.	Processing of SMDT1;Mitochondrial calcium ion transport	PE1	22
+NX_Q9H4K1	RIB43A-like with coiled-coils protein 2	309	37060	9.57	0	NA	NA	NA	NA	Belongs to the RIB43A family.	NA	PE1	22
+NX_Q9H4K7	Mitochondrial ribosome-associated GTPase 2	406	43955	9.52	0	Mitochondrion inner membrane;Mitochondrion	NA	Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.	NA	Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.	NA	PE1	20
+NX_Q9H4L4	Sentrin-specific protease 3	574	65010	8.82	0	Nucleoplasm;Cytoplasm;Nucleolus;Nucleus	NA	Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.	NA	Belongs to the peptidase C48 family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	17
+NX_Q9H4L5	Oxysterol-binding protein-related protein 3	887	101224	6.42	0	Filopodium tip;Endoplasmic reticulum membrane;Cell membrane;Nucleus membrane;Nucleolus;Cytosol	NA	Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).	Phosphorylation is enhanced in vitro by phorbol-12-myristate-13-acetate (PMA), forskolin and calcium ionophore A23187 (PubMed:25447204). Phosphorylation seems to be stimulated in conditions of low cell-cell (or cell-matrix) adhesion (PubMed:18270267).	Belongs to the OSBP family.	Synthesis of bile acids and bile salts	PE1	7
+NX_Q9H4L7	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1	1026	117402	5.39	0	Nucleoplasm;Nucleus;Chromosome	Huriez syndrome;Adermatoglyphia;Basan syndrome	DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing.	NA	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	4
+NX_Q9H4M3	F-box only protein 44	255	29747	5.52	0	Nucleoplasm	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	1
+NX_Q9H4M7	Pleckstrin homology domain-containing family A member 4	779	85401	10.57	0	Cytoplasm;Cell membrane;Centriolar satellite;Membrane;Cytosol;Cytoskeleton	NA	Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.	NA	NA	Synthesis of PIPs at the plasma membrane	PE1	19
+NX_Q9H4M9	EH domain-containing protein 1	534	60627	6.35	0	Cilium membrane;Early endosome membrane;Recycling endosome membrane;Cell membrane	NA	ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250).	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.	Endocytosis;Factors involved in megakaryocyte development and platelet production	PE1	11
+NX_Q9H4P4	E3 ubiquitin-protein ligase NRDP1	317	35905	5.75	0	Nucleoplasm;Nucleus;Midbody ring	NA	Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).	Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.	NA	Protein modification; protein ubiquitination.;Endocytosis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downregulation of ERBB2:ERBB3 signaling	PE1	12
+NX_Q9H4Q3	PR domain zinc finger protein 13	707	73981	9	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE2	6
+NX_Q9H4Q4	PR domain zinc finger protein 12	367	40403	8.58	0	Nucleoplasm;Nucleus	Neuropathy, hereditary sensory and autonomic, 8	Involved in the positive regulation of histone H3-K9 dimethylation.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE1	9
+NX_Q9H4R4	Putative nuclear receptor corepressor 1-like protein NCOR1P1	102	11336	6.96	0	NA	NA	NA	NA	Belongs to the N-CoR nuclear receptor corepressors family.	NA	PE5	20
+NX_Q9H4S2	GS homeobox 1	264	27883	9.17	0	Nucleus	NA	Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.	NA	Belongs to the Antp homeobox family.	NA	PE2	13
+NX_Q9H4T2	Zinc finger and SCAN domain-containing protein 16	348	40792	8.36	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_Q9H4W6	Transcription factor COE3	596	64864	8.91	0	Nucleus	Hypotonia, ataxia, and delayed development syndrome	Transcriptional activator (PubMed:28017373, PubMed:28017372, PubMed:28017370). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).	NA	Belongs to the COE family.	NA	PE1	10
+NX_Q9H4X1	Regulator of cell cycle RGCC	137	14559	4.59	0	Cytoplasm;Nucleolus;Nucleoplasm;Centrosome;Nucleus	NA	Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.	NA	NA	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	13
+NX_Q9H4Y5	Glutathione S-transferase omega-2	243	28254	7.51	0	NA	NA	Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).	NA	Belongs to the GST superfamily. Omega family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Glutathione conjugation;Vitamin C (ascorbate) metabolism	PE1	10
+NX_Q9H4Z2	Zinc finger protein 335	1342	144893	5.97	0	Nucleoplasm;Nucleus	Microcephaly 10, primary, autosomal recessive	Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	20
+NX_Q9H4Z3	mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase	704	80670	7.09	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178).	NA	Belongs to the CAPAM family.	NA	PE1	20
+NX_Q9H501	ESF1 homolog	851	98796	5.01	0	Nucleoplasm;Nucleolus	NA	May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity).	NA	Belongs to the ESF1 family.	NA	PE1	20
+NX_Q9H503	Barrier-to-autointegration factor-like protein	90	10309	5.5	0	Cytoplasm;Nucleus	NA	May play a role in BANF1 regulation and influence tissue-specific roles of BANF1.	NA	Belongs to the BAF family.	NA	PE1	20
+NX_Q9H511	Kelch-like protein 31	634	70246	6.3	0	Nucleus	NA	Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).	N-terminus is methylated by METTL11A/NTM1.	NA	NA	PE1	6
+NX_Q9H521	Putative uncharacterized protein LOC645739	79	9322	4.71	0	NA	NA	NA	NA	NA	NA	PE5	13
+NX_Q9H553	Alpha-1,3/1,6-mannosyltransferase ALG2	416	47092	6.61	1	Membrane;Cytosol;Cytoskeleton	Myasthenic syndrome, congenital, 14;Congenital disorder of glycosylation 1I	Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.	NA	Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG2 causes ALG2-CDG (CDG-1i)	PE1	9
+NX_Q9H560	Putative ankyrin repeat domain-containing protein 19	264	30436	9.15	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_Q9H568	Actin-like protein 8	366	41360	5.78	0	Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the actin family.	NA	PE1	1
+NX_Q9H579	Protein MROH8	483	54816	5.96	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	20
+NX_Q9H582	Zinc finger protein 644	1327	149565	8.43	0	Cytoplasmic vesicle;Nucleus	Myopia 21, autosomal dominant	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_Q9H583	HEAT repeat-containing protein 1	2144	242370	6.11	0	Mitochondrion;Nucleolus	NA	Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.	NA	Belongs to the HEATR1/UTP10 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	1
+NX_Q9H596	Dual specificity protein phosphatase 21	190	21529	8.95	0	Cytoplasm;Mitochondrion inner membrane;Nucleus	NA	Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	X
+NX_Q9H598	Vesicular inhibitory amino acid transporter	525	57415	6.19	10	Cytoplasmic vesicle membrane	NA	Involved in the uptake of GABA and glycine into the synaptic vesicles.	NA	Belongs to the amino acid/polyamine transporter 2 family.	Synaptic vesicle cycle;GABAergic synapse;GABA synthesis, release, reuptake and degradation;Transport of inorganic cations/anions and amino acids/oligopeptides	PE1	20
+NX_Q9H5F2	UPF0686 protein C11orf1	150	17785	8.68	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the UPF0686 family.	NA	PE1	11
+NX_Q9H5H4	Zinc finger protein 768	540	60229	8.27	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	16
+NX_Q9H5I1	Histone-lysine N-methyltransferase SUV39H2	410	46682	8.55	0	Centromere;Mitochondrion;Nucleus	NA	Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	Lysine degradation;PKMTs methylate histone lysines	PE1	10
+NX_Q9H5I5	Piezo-type mechanosensitive ion channel component 2	2752	318064	5.82	37	Cell membrane;Membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	Arthrogryposis, distal, with impaired proprioception and touch;Arthrogryposis, distal, 5;Arthrogryposis, distal, 3;Marden-Walker syndrome	Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation.	NA	Belongs to the PIEZO (TC 1.A.75) family.	NA	PE1	18
+NX_Q9H5J0	Zinc finger and BTB domain-containing protein 3	574	61827	5.4	0	Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	11
+NX_Q9H5J4	Elongation of very long chain fatty acids protein 6	265	31376	9.42	7	Endoplasmic reticulum membrane	NA	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.	N-Glycosylated.	Belongs to the ELO family. ELOVL6 subfamily.	Lipid metabolism; fatty acid biosynthesis.;Fatty acid elongation;Biosynthesis of unsaturated fatty acids;Synthesis of very long-chain fatty acyl-CoAs;Activation of gene expression by SREBF (SREBP)	PE1	4
+NX_Q9H5J8	TATA box-binding protein-associated factor RNA polymerase I subunit D	278	32058	8.8	0	Centriolar satellite;Nucleolus;Nucleoplasm;Spindle;Nucleus	NA	Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.	NA	NA	NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;SIRT1 negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression	PE1	11
+NX_Q9H5K3	Protein O-mannose kinase	350	40050	5.68	1	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane	Muscular dystrophy-dystroglycanopathy limb-girdle C12;Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A12	Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.	O-linked glycosylation	PE1	8
+NX_Q9H5L6	DNA transposase THAP9	903	103411	9.26	0	Mitochondrion	NA	Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition.	NA	NA	NA	PE1	4
+NX_Q9H5L9	Putative uncharacterized protein C5orf66	145	15570	8.9	0	NA	NA	NA	NA	NA	NA	PE5	5
+NX_Q9H5N1	Rab GTPase-binding effector protein 2	569	63543	4.76	0	Cytoplasm;Early endosome;Cilium basal body;Centrosome;Cytoplasmic vesicle;Cytosol	NA	Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062).	NA	Belongs to the rabaptin family.	NA	PE1	16
+NX_Q9H5P4	PDZ domain-containing protein 7	1033	111752	9.74	0	Stereocilium;Nucleoplasm;Cilium;Nucleus	Usher syndrome 2C;Deafness, autosomal recessive, 57;Usher syndrome 2A	In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1.	NA	NA	NA	PE1	10
+NX_Q9H5Q4	Dimethyladenosine transferase 2, mitochondrial	396	45349	9.3	0	Mitochondrion	NA	S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.	Transcriptional activation of mitochondrial biogenesis;Mitochondrial transcription initiation	PE1	1
+NX_Q9H5U6	rRNA N6-adenosine-methyltransferase ZCCHC4	513	59010	9.06	0	Golgi apparatus;Cytoplasm;Nucleus speckle;Nucleolus	NA	RRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910).	NA	Belongs to the ZCCHC4 family.	NA	PE1	4
+NX_Q9H5V7	Zinc finger protein Pegasus	419	46510	7.09	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor.	NA	Belongs to the Ikaros C2H2-type zinc-finger protein family.	NA	PE1	10
+NX_Q9H5V8	CUB domain-containing protein 1	836	92932	8.28	1	Secreted;Cell membrane	NA	May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.	N-glycosylated.;A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.;Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.	NA	NA	PE1	3
+NX_Q9H5V9	UPF0428 protein CXorf56	222	25625	8.94	0	Nucleoplasm;Cytoplasm;Centrosome;Nucleus	Mental retardation, X-linked 107	NA	NA	Belongs to the UPF0428 family.	NA	PE1	X
+NX_Q9H5X1	Cytosolic iron-sulfur assembly component 2A	160	18355	4.88	0	Nucleoplasm;Cytoplasm;Cytosol	NA	Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004). As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation (PubMed:23891004). May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 (PubMed:25716227).	NA	Belongs to the MIP18 family.	NA	PE1	15
+NX_Q9H5Y7	SLIT and NTRK-like protein 6	841	95110	6.07	1	Endoplasmic reticulum;Cell membrane	Deafness and myopia	Regulator of neurite outgrowth required for normal hearing and vision.	NA	Belongs to the SLITRK family.	Receptor-type tyrosine-protein phosphatases	PE1	13
+NX_Q9H5Z1	Probable ATP-dependent RNA helicase DHX35	703	78910	8.81	0	Nucleoplasm;Centrosome;Nucleus	NA	May be involved in pre-mRNA splicing.	NA	Belongs to the DEAD box helicase family. DEAH subfamily.	NA	PE1	20
+NX_Q9H5Z6	Protein FAM124B	455	50961	6.86	0	Nucleoplasm;Mitochondrion;Nucleus	NA	NA	NA	Belongs to the FAM124 family.	NA	PE1	2
+NX_Q9H606	Proline-rich protein, Y-linked	182	19976	10.13	0	NA	NA	NA	NA	NA	NA	PE2	Y
+NX_Q9H607	Occludin/ELL domain-containing protein 1	264	29404	10.01	0	Golgi apparatus	NA	NA	NA	Belongs to the ELL/occludin family.	NA	PE2	19
+NX_Q9H609	Zinc finger protein 576	170	18890	8.79	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q9H611	ATP-dependent DNA helicase PIF1	641	69799	9.81	0	Nucleoplasm;Mitochondrion;Nucleus	NA	DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.	NA	Belongs to the helicase family. PIF1 subfamily.	NA	PE1	15
+NX_Q9H628	Ras-related and estrogen-regulated growth inhibitor-like protein	205	23855	9.56	0	Nucleoplasm	NA	Binds GDP/GTP and may possess intrinsic GTPase activity.	NA	Belongs to the small GTPase superfamily. Ras family.	NA	PE2	12
+NX_Q9H633	Ribonuclease P protein subunit p21	154	17570	9.64	0	Nucleolus	NA	Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.	NA	Belongs to the eukaryotic/archaeal RNase P protein component 4 family.	RNA transport;tRNA processing in the nucleus;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	6
+NX_Q9H649	tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial	340	38244	9.09	0	Nucleoplasm;Mitochondrion matrix;Nucleus membrane	NA	Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met) (PubMed:27497299, PubMed:27214402, PubMed:27356879). Mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position (PubMed:27497299, PubMed:27214402, PubMed:27356879). Mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299, PubMed:27356879).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	NA	PE1	3
+NX_Q9H665	IGF-like family receptor 1	355	37895	6.7	1	Focal adhesion;Cell membrane	NA	Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.	NA	NA	NA	PE1	19
+NX_Q9H668	CST complex subunit STN1	368	42119	5.72	0	Nucleoplasm;Telomere;Nucleus	Cerebroretinal microangiopathy with calcifications and cysts 2	Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.;Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22964711, PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres (PubMed:22863775, PubMed:22964711). Promotes general replication start following replication-fork stalling implicating new origin firing (PubMed:22863775). May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (PubMed:23142664).	NA	Belongs to the STN1 family.	NA	PE1	10
+NX_Q9H672	Ankyrin repeat and SOCS box protein 7	318	36011	8.57	0	Golgi apparatus;Cytoplasmic vesicle;Nucleoplasm	NA	Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	15
+NX_Q9H693	Uncharacterized protein C16orf95	158	16793	9.83	0	Endoplasmic reticulum	NA	NA	NA	NA	NA	PE1	16
+NX_Q9H694	Protein bicaudal C homolog 1	974	104844	8.75	0	Cytoplasm;Nucleoplasm	Renal dysplasia, cystic	Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.	NA	Belongs to the BicC family.	NA	PE1	10
+NX_Q9H6A0	DENN domain-containing protein 2D	471	53672	7.55	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	1
+NX_Q9H6A9	Pecanex-like protein 3	2034	222039	6.19	13	Membrane;Cytosol	NA	NA	NA	Belongs to the pecanex family.	NA	PE1	11
+NX_Q9H6B1	Zinc finger protein 385D	395	42296	10.04	0	Nucleus	NA	NA	NA	NA	NA	PE1	3
+NX_Q9H6B4	CXADR-like membrane protein	373	41281	8.11	1	Tight junction;Cell membrane	Congenital short bowel syndrome	May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.	NA	NA	NA	PE1	11
+NX_Q9H6B9	Epoxide hydrolase 3	360	40909	7.67	1	Microsome membrane;Nucleoplasm	NA	Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin.	NA	Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.	NA	PE1	19
+NX_Q9H6D3	XK-related protein 8	395	44655	7.62	8	Golgi apparatus;Endoplasmic reticulum;Cell membrane	NA	Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.	Undergoes proteolytic processing by caspase-3 (CASP3), leading to its activation.	Belongs to the XK family.	NA	PE1	1
+NX_Q9H6D7	HAUS augmin-like complex subunit 4	363	42400	5.52	0	Spindle;Focal adhesion;Centrosome;Cell membrane	NA	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.	NA	Belongs to the HAUS4 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	14
+NX_Q9H6D8	Fibronectin type III domain-containing protein 4	234	25159	8.39	1	Membrane;Nucleoplasm;Cytosol;Secreted	NA	Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.	NA	NA	NA	PE1	2
+NX_Q9H6E4	Coiled-coil domain-containing protein 134	229	26561	8.89	0	Endoplasmic reticulum;Cytoplasm;Secreted;Nucleus	NA	In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.;In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).	O-glycosylated, with additional sialic acid modifications.	Belongs to the CCDC134 family.	NA	PE1	22
+NX_Q9H6E5	Speckle targeted PIP5K1A-regulated poly(A) polymerase	874	93847	5.8	0	Nucleoplasm;Cytosol;Nucleus speckle;Nucleolus	NA	Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.	Phosphorylated by CK1 in the proline-rich (Pro-rich) region.;TUT1 is phosphorylated by CSNK1A1	Belongs to the DNA polymerase type-B-like family.	NA	PE1	11
+NX_Q9H6F2	Trimeric intracellular cation channel type A	299	33260	8.56	7	Nucleoplasm;Nucleus membrane;Sarcoplasmic reticulum membrane	NA	Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.	NA	Belongs to the TMEM38 family.	NA	PE1	19
+NX_Q9H6F5	Coiled-coil domain-containing protein 86	360	40236	10.33	0	Nucleoplasm;Nucleolus;Nucleus	NA	NA	Citrullinated by PADI4.	NA	NA	PE1	11
+NX_Q9H6H4	Receptor expression-enhancing protein 4	257	29395	9.74	2	Cytosol;Endoplasmic reticulum membrane	NA	Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.	NA	Belongs to the DP1 family.	Olfactory Signaling Pathway	PE1	8
+NX_Q9H6I2	Transcription factor SOX-17	414	44117	6	0	Nucleoplasm;Nucleus	Vesicoureteral reflux 3	Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells.	NA	NA	Wnt signaling pathway;Deactivation of the beta-catenin transactivating complex	PE1	8
+NX_Q9H6J7	UPF0705 protein C11orf49	331	37353	5.16	0	Cytoplasm;Nucleus speckle;Nucleus	NA	NA	NA	Belongs to the UPF0705 family.	NA	PE1	11
+NX_Q9H6K1	Protein ILRUN	298	32872	4.43	0	Cytoplasm;Nucleus speckle;Centrosome;Nucleus	NA	Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199).	NA	NA	NA	PE1	6
+NX_Q9H6K4	Optic atrophy 3 protein	179	19996	9.07	0	Nucleoplasm;Cytosol;Mitochondrion	Optic atrophy 3;3-methylglutaconic aciduria 3	May play some role in mitochondrial processes.	NA	Belongs to the OPA3 family.	NA	PE1	19
+NX_Q9H6K5	Proline-rich protein 36	1346	132748	10.48	0	Golgi apparatus;Nucleoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q9H6L2	Transmembrane protein 231	316	36059	7.76	2	Cilium membrane;Cytoplasmic vesicle	Joubert syndrome 20;Meckel syndrome 11	Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).	NA	Belongs to the TMEM231 family.	NA	PE1	16
+NX_Q9H6L4	Armadillo repeat-containing protein 7	198	21924	5.73	0	Cytosol	NA	NA	NA	NA	NA	PE1	17
+NX_Q9H6L5	Reticulophagy regulator 1	497	54681	4.53	4	Endoplasmic reticulum;cis-Golgi network membrane;Endoplasmic reticulum membrane	Neuropathy, hereditary sensory and autonomic, 2B	Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720).	NA	Belongs to the RETREG family.	NA	PE1	5
+NX_Q9H6N6	Putative uncharacterized protein MYH16	1097	128290	5.4	0	NA	NA	Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	7
+NX_Q9H6P5	Threonine aspartase 1	420	44455	7.89	0	Cell membrane	NA	Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster.	NA	Belongs to the Ntn-hydrolase family.	NA	PE1	20
+NX_Q9H6Q3	Src-like-adapter 2	261	28585	5.23	0	Golgi apparatus;Cytoplasm;Cell membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.	Phosphorylated by CSF1R.	NA	NA	PE1	20
+NX_Q9H6Q4	Cytosolic iron-sulfur assembly component 3	476	53020	6.81	0	Cytosol;Cell membrane	NA	Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.	NA	Belongs to the NARF family.	Cytosolic iron-sulfur cluster assembly	PE1	16
+NX_Q9H6R0	ATP-dependent RNA helicase DHX33	707	78874	9.08	0	Cytoplasm;Inflammasome;Nucleolus;Nucleoplasm;Nucleus	NA	Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity).	Ubiquitinated, leading to its degradation by the proteasome. Deubiquitinated by USP36.	Belongs to the DEAD box helicase family. DEAH subfamily.	NA	PE1	17
+NX_Q9H6R3	Acyl-CoA synthetase short-chain family member 3, mitochondrial	686	74778	8.84	0	Mitochondrion matrix;Mitochondrion	NA	Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:28003429). Propionate is the preferred substrate (PubMed:28003429). Can utilize acetate and butyrate with a much lower affinity (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Propanoate metabolism;Metabolic pathways;Synthesis of Ketone Bodies	PE1	12
+NX_Q9H6R4	Nucleolar protein 6	1146	127593	7.42	0	Nucleoplasm;Nucleolus;Chromosome	NA	NA	NA	Belongs to the NRAP family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	9
+NX_Q9H6R6	Palmitoyltransferase ZDHHC6	413	47663	8.81	4	Endoplasmic reticulum membrane	NA	Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151, PubMed:28826475). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (PubMed:22314232). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (PubMed:22728137). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151).	Palmitoylated at 3 different sites by ZDHHC16 (PubMed:28826475). The combination of the different palmitoylation events strongly affects the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). Palmitoylation at Cys-328 accelerates the turnover of ZDHHC6 (PubMed:28826475). Depalmitoylated by LYPLA2 (PubMed:28826475).	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	10
+NX_Q9H6R7	WD repeat and coiled-coil-containing protein	721	79136	6.23	0	Cytosol;Nucleolus	NA	NA	Phosphorylated on Tyr when associated with HCK.	NA	NA	PE1	2
+NX_Q9H6S0	3'-5' RNA helicase YTHDC2	1430	160248	8.68	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity).	NA	Belongs to the DEAD box helicase family. DEAH subfamily.	NA	PE1	5
+NX_Q9H6S1	5-azacytidine-induced protein 2	392	44935	6.15	0	Cytoplasm	NA	Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.	NA	NA	RIG-I-like receptor signaling pathway	PE1	3
+NX_Q9H6S3	Epidermal growth factor receptor kinase substrate 8-like protein 2	715	80621	6.39	0	Stereocilium;Cytoplasm;Cytosol;Cell membrane	Deafness, autosomal recessive, 106	Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).	NA	Belongs to the EPS8 family.	NA	PE1	11
+NX_Q9H6T0	Epithelial splicing regulatory protein 2	727	78401	6.27	0	Nucleoplasm;Nucleus	NA	MRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.	NA	Belongs to the ESRP family.	FGFR2 alternative splicing	PE1	16
+NX_Q9H6T3	RNA polymerase II-associated protein 3	665	75719	6.46	0	Cytosol	NA	Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.	NA	Belongs to the RPAP3 family.	NA	PE1	12
+NX_Q9H6U6	Breast carcinoma-amplified sequence 3	928	101237	6.23	0	Cytoplasm;Nucleolus;Nucleus;Cytoskeleton	NA	Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin.	NA	Belongs to the BCAS3 family.	NA	PE1	17
+NX_Q9H6U8	Alpha-1,2-mannosyltransferase ALG9	611	69863	8.91	8	Endoplasmic reticulum;Endoplasmic reticulum membrane	Gillessen-Kaesbach-Nishimura syndrome;Congenital disorder of glycosylation 1L	Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides.	NA	Belongs to the glycosyltransferase 22 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG9 causes ALG9-CDG (CDG-1l)	PE1	11
+NX_Q9H6V9	Lipid droplet-associated hydrolase	325	37319	6.09	0	Endoplasmic reticulum;Cytosol;Nucleus speckle;Lipid droplet	NA	Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.	NA	Belongs to the AB hydrolase superfamily. LDAH family.	NA	PE1	2
+NX_Q9H6W3	Ribosomal oxygenase 1	641	71086	6.02	0	Nucleoplasm;Nucleolus	NA	Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.	NA	Belongs to the ROX family. NO66 subfamily.	NA	PE1	14
+NX_Q9H6X2	Anthrax toxin receptor 1	564	62789	7.54	1	Cytoplasmic vesicle;Filopodium membrane;Lamellipodium membrane;Cell membrane	GAPO syndrome;Hemangioma, capillary infantile	Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.	NA	Belongs to the ATR family.	Uptake and function of anthrax toxins	PE1	2
+NX_Q9H6X4	Transmembrane protein 134	195	21586	6.08	2	Membrane;Cytosol;Perinuclear region	NA	NA	NA	Belongs to the TMEM134/TMEM230 family.	NA	PE1	11
+NX_Q9H6X5	Uncharacterized protein C19orf44	657	71343	5.52	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	19
+NX_Q9H6Y2	WD repeat-containing protein 55	383	42070	4.78	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).	NA	Belongs to the WD repeat WDR55 family.	NA	PE1	5
+NX_Q9H6Y5	PDZ domain-containing protein MAGIX	334	35273	10.79	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	X
+NX_Q9H6Y7	E3 ubiquitin-protein ligase RNF167	350	38299	5.37	1	Endomembrane system	NA	May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.	Auto-ubiquitinated in vitro in the presence of UBE2D1 and UBE2E1.	NA	Protein modification; protein ubiquitination.	PE1	17
+NX_Q9H6Z4	Ran-binding protein 3	567	60210	4.7	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.	NA	NA	HTLV-I infection	PE1	19
+NX_Q9H6Z9	Egl nine homolog 3	239	27261	7.56	0	Cytoplasm;Cytosol;Nucleus	NA	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation. Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway. Target proteins are preferentially recognized via a LXXLAP motif.	NA	NA	Pathways in cancer;Renal cell carcinoma;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	PE1	14
+NX_Q9H706	GRB2-associated and regulator of MAPK protein 1	876	97186	6.32	0	Nucleoplasm;Cytosol	NA	Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.	On EGF stimulation, phosphorylated on Tyr-105 and Tyr-453.	Belongs to the GAREM family.	NA	PE1	18
+NX_Q9H707	Zinc finger protein 552	407	46198	8.84	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9H714	Protein associated with UVRAG as autophagy enhancer	662	73457	5.69	0	Autophagosome membrane;Cytosol	NA	Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable).	Phosphorylated by MTOR at Ser-157 under nutrient-rich conditions (PubMed:30704899). Phosphorylation prevents acetylation by KAT5/TIP60 and impairs RUBCNL/PACER function and autophagosome maturation (PubMed:30704899). Under autophagy induction, Phosphorylation by MTOR is repressed, enabling acetylation by KAT5/TIP60 (PubMed:30704899).;Acetylated by KAT5/TIP60 under autophagy induction, promoting autophagosome maturation and lipid metabolism (PubMed:30704899). Acetylation is prevented by phosphorylation by MTOR (PubMed:30704899). Lys-483 and Lys-573 constitute the key sites for tuning function in autophagy (PubMed:30704899).	NA	NA	PE1	13
+NX_Q9H720	PGAP2-interacting protein	699	78584	8.75	10	Membrane	NA	Involved in lipid remodeling during GPI-anchor maturation.	NA	Belongs to the PGAP2IP family.	NA	PE1	4
+NX_Q9H741	UPF0454 protein C12orf49	205	23594	8.49	0	Secreted	NA	NA	NA	Belongs to the UPF0454 family.	NA	PE1	12
+NX_Q9H756	Leucine-rich repeat-containing protein 19	370	42334	5.01	1	Membrane	NA	NA	NA	NA	NA	PE1	9
+NX_Q9H765	Ankyrin repeat and SOCS box protein 8	288	31642	5.58	0	Cytoplasm	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	12
+NX_Q9H772	Gremlin-2	168	19320	9.36	0	Secreted	Tooth agenesis, selective, 9	Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.	N-glycosylated.	Belongs to the DAN family.	Signaling by BMP	PE1	1
+NX_Q9H773	dCTP pyrophosphatase 1	170	18681	4.93	0	Nucleoplasm;Cytosol;Mitochondrion;Nucleus	NA	Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	NA	NA	Interconversion of nucleotide di- and triphosphates	PE1	16
+NX_Q9H777	Zinc phosphodiesterase ELAC protein 1	363	40019	6.32	0	Nucleoplasm;Cytosol;Nucleus	NA	Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.	NA	Belongs to the RNase Z family.	RNA transport	PE1	18
+NX_Q9H788	SH2 domain-containing protein 4A	454	52727	8.09	0	Cytoplasm;Cytosol	NA	Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.	NA	NA	NA	PE1	8
+NX_Q9H790	Exonuclease V	373	41816	5.28	0	Nucleoplasm;Cytosol;Nucleus	NA	Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity.	NA	Belongs to the EXO5 family.	NA	PE1	1
+NX_Q9H792	Inactive tyrosine-protein kinase PEAK1	1746	193106	6.46	0	Focal adhesion;Cytoskeleton	NA	Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:23105102, PubMed:20534451). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654).	Phosphorylated on tyrosine in a CSK-dependent manner in response to adhesion to fibronectin and to EGF stimulation (PubMed:20534451). Phosphorylation at Tyr-665 by a Src family kinase controls subcellular localization to focal adhesion and focal adhesion dynamics (PubMed:20534451). Phosphorylation at Tyr-1188 is essential for binding to SHC1 (PubMed:23846654).;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily.	NA	PE1	15
+NX_Q9H799	Ciliogenesis and planar polarity effector 1	3197	361746	6.55	2	Membrane;Cytosol;Cilium	Joubert syndrome 17;Orofaciodigital syndrome 6	Involved in ciliogenesis (PubMed:25877302). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity).	NA	NA	NA	PE1	5
+NX_Q9H7B2	Ribosome production factor 2 homolog	306	35583	10	0	Nucleoplasm;Nucleolus;Nucleus	NA	Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.	NA	Belongs to the RPF2 family.	NA	PE1	6
+NX_Q9H7B4	Histone-lysine N-methyltransferase SMYD3	428	49097	7.05	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family.	PKMTs methylate histone lysines	PE1	1
+NX_Q9H7B7	Uncharacterized protein C7orf69	122	14425	9.47	0	Secreted	NA	NA	NA	NA	NA	PE2	7
+NX_Q9H7C4	Syncoilin	482	55299	4.59	0	Cytoplasmic vesicle;Golgi apparatus;Perinuclear region;Cell membrane	NA	Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins.	NA	Belongs to the intermediate filament family.	NA	PE1	1
+NX_Q9H7C9	Mth938 domain-containing protein	122	13332	8.58	0	Nucleoplasm;Cytoplasm;Cytosol	NA	May play a role in preadipocyte differentiation and adipogenesis.	NA	Belongs to the AAMDC family.	NA	PE1	11
+NX_Q9H7D0	Dedicator of cytokinesis protein 5	1870	215309	8.08	0	Cytoplasm;Cytosol;Cell membrane	NA	Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).	NA	Belongs to the DOCK family.	Factors involved in megakaryocyte development and platelet production	PE1	8
+NX_Q9H7D7	WD repeat-containing protein 26	661	72124	5.74	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	Skraban-Deardorff syndrome	G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).	NA	NA	NA	PE1	1
+NX_Q9H7E2	Tudor domain-containing protein 3	651	73185	9.27	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol;Nucleus	NA	Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.	NA	NA	NA	PE1	13
+NX_Q9H7E9	UPF0488 protein C8orf33	229	24993	9.99	0	Nucleoplasm;Cell membrane	NA	NA	NA	Belongs to the UPF0488 family.	NA	PE1	8
+NX_Q9H7F0	Probable cation-transporting ATPase 13A3	1226	138043	6.21	11	Membrane;Cytosol;Nucleolus;Cell membrane	NA	NA	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.	NA	PE1	3
+NX_Q9H7F4	Transmembrane protein 185B	350	40599	7.66	7	Membrane	NA	NA	NA	Belongs to the TMEM185 family.	NA	PE1	2
+NX_Q9H7H0	Methyltransferase-like protein 17, mitochondrial	456	50734	9.45	0	Nucleoplasm;Mitochondrion	NA	May be a component of the mitochondrial small ribosomal subunit.	NA	Belongs to the methyltransferase superfamily. Rsm22 family.	NA	PE1	14
+NX_Q9H7J1	Protein phosphatase 1 regulatory subunit 3E	279	30644	11.16	0	Spindle;Mitochondrion;Cytoskeleton	NA	Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis.	NA	NA	NA	PE1	14
+NX_Q9H7L2	Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1	352	38777	8.69	0	Secreted	NA	NA	NA	NA	NA	PE5	19
+NX_Q9H7L9	Sin3 histone deacetylase corepressor complex component SDS3	328	38136	5.55	0	Cytosol;Nucleus	NA	Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.	Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.	Belongs to the SDS3 family.	NoRC negatively regulates rRNA expression;HDACs deacetylate histones;Ub-specific processing proteases	PE1	12
+NX_Q9H7M6	Zinc finger SWIM domain-containing protein 4	989	110138	6.63	0	NA	NA	NA	NA	NA	NA	PE1	19
+NX_Q9H7M9	V-type immunoglobulin domain-containing suppressor of T-cell activation	311	33908	6.45	1	Nucleoplasm;Cell membrane	NA	Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).	N-glycosylated.;At the cell surface, may be cleaved by MMP14.	NA	NA	PE1	10
+NX_Q9H7N4	Splicing factor, arginine/serine-rich 19	1312	139270	9.31	0	Nucleoplasm;Cytosol;Nucleus	NA	May function in pre-mRNA splicing.	NA	Belongs to the splicing factor SR family.	NA	PE1	19
+NX_Q9H7P6	Multivesicular body subunit 12B	319	35620	8.42	0	Golgi apparatus;Cytoplasmic vesicle;Endosome;Late endosome membrane	NA	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.	NA	Belongs to the MVB12 family.	Endocytosis;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	9
+NX_Q9H7P9	Pleckstrin homology domain-containing family G member 2	1386	147969	5.57	0	Nucleoplasm;Cytosol	Leukodystrophy and acquired microcephaly with or without dystonia	May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021).	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	19
+NX_Q9H7R0	Zinc finger protein 442	627	72863	9.03	0	Cytoplasmic vesicle;Nucleus;Nucleus membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q9H7R5	Zinc finger protein 665	678	77640	9.3	0	Nucleus;Nucleus membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9H7S9	Zinc finger protein 703	590	58222	8.99	0	Cytoplasm;Nucleus	NA	Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.	NA	Belongs to the Elbow/Noc family.	Generic Transcription Pathway	PE1	8
+NX_Q9H7T0	Cation channel sperm-associated protein subunit beta	1116	126924	6.72	4	Membrane;Cytoplasmic vesicle	NA	Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.	NA	NA	Sperm Motility And Taxes	PE1	14
+NX_Q9H7T3	Uncharacterized protein C10orf95	257	26270	11.69	0	NA	NA	NA	NA	NA	NA	PE1	10
+NX_Q9H7T9	Aurora kinase A and ninein-interacting protein	357	40253	7.19	0	Spindle pole;Centrosome;Nucleus;Chromosome	NA	DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non-homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670).	AUNIP is phosphorylated by AURKA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the AUNIP family.	NA	PE1	1
+NX_Q9H7U1	Serine-rich coiled-coil domain-containing protein 2	834	93548	6.4	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	Microtubule-binding protein which might play a role in microtubule bundling.	NA	Belongs to the CCSER family.	NA	PE1	10
+NX_Q9H7V2	Synapse differentiation-inducing gene protein 1	258	28551	4.74	1	Dendritic spine;Cell membrane;Postsynaptic density;Synapse;Early endosome membrane;Cytoplasmic vesicle;Dendrite	NA	May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation.	NA	Belongs to the CD225/Dispanin family.	NA	PE1	20
+NX_Q9H7X0	N-alpha-acetyltransferase 60	242	27451	7.21	0	Golgi apparatus membrane;Cytosol;Cytoskeleton	NA	N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917).	Acetylated: autoacetylation is required for optimal acetyltransferase activity.	Belongs to the acetyltransferase family. NAA60 subfamily.	NA	PE1	16
+NX_Q9H7X2	Uncharacterized protein C1orf115	142	15517	9.87	1	Membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q9H7X3	Zinc finger protein 696	374	40575	9.26	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	8
+NX_Q9H7X7	Intraflagellar transport protein 22 homolog	185	20835	5.03	0	Cytosol;Cilium;Cytoskeleton	NA	Small GTPase-like component of the intraflagellar transport (IFT) complex B.	NA	Belongs to the small GTPase superfamily. Rab family.	Intraflagellar transport	PE1	7
+NX_Q9H7Y0	Divergent protein kinase domain 2B	433	48555	8.11	0	Secreted	NA	NA	NA	Belongs to the DIPK family.	NA	PE1	X
+NX_Q9H7Z3	Nuclear exosome regulator NRDE2	1164	132673	7.72	0	Nucleus speckle;Mitochondrion;Nucleolus;Nucleoplasm;Nucleus	NA	Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217).	NA	Belongs to the NRDE2 family.	NA	PE1	14
+NX_Q9H7Z6	Histone acetyltransferase KAT8	458	52403	8.48	0	Nucleoplasm;Nucleus;Chromosome	NA	Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126). May influence the function of ATM (PubMed:15923642). As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026). That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026). Can also acetylate TP53/p53 at 'Lys-120'.	Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function.	Belongs to the MYST (SAS/MOZ) family.	HATs acetylate histones	PE1	16
+NX_Q9H7Z7	Prostaglandin E synthase 2	377	41943	9.22	1	Golgi apparatus membrane;Mitochondrion;Perinuclear region	NA	Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).	NA	Belongs to the GST superfamily.	Lipid metabolism; prostaglandin biosynthesis.;Arachidonic acid metabolism;Metabolic pathways;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Neutrophil degranulation	PE1	9
+NX_Q9H808	Transducin-like enhancer protein 6	572	63473	5.78	0	Cytoplasm	Preimplantation embryonic lethality 1	As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.	NA	Belongs to the WD repeat Groucho/TLE family.	NA	PE1	19
+NX_Q9H813	Proton-activated chloride channel	350	40043	9.01	2	Cell membrane	NA	Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH (PubMed:31023925). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925).	NA	Belongs to the proton-activated chloride channel family.	NA	PE1	1
+NX_Q9H814	Phosphorylated adapter RNA export protein	394	44403	5.27	0	Cajal body;Nucleoplasm;Cytoplasm	NA	A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.	Phosphorylated in the nucleus. Dephosphorylated in the cytoplasm (By similarity).	Belongs to the PHAX family.	RNA transport;snRNP Assembly;RNA polymerase II transcribes snRNA genes	PE1	5
+NX_Q9H816	5' exonuclease Apollo	532	60002	8.64	0	Nucleoplasm;Centrosome;Telomere;Nucleus	Hoyeraal-Hreidarsson syndrome	5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.	Ubiquitinated, leading to its degradation. Interaction with TERF2 protects it from ubiquitination.	Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.	Fanconi Anemia Pathway	PE1	1
+NX_Q9H819	DnaJ homolog subfamily C member 18	358	41551	7.04	1	Membrane;Cell junction	NA	NA	NA	NA	NA	PE1	5
+NX_Q9H825	mRNA N(3)-methylcytidine methyltransferase METTL8	291	33387	6.46	0	Cytoplasm;Cytosol;Nucleus	NA	S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs.	NA	Belongs to the methyltransferase superfamily. METL family.	NA	PE1	2
+NX_Q9H832	Ubiquitin-conjugating enzyme E2 Z	354	38210	5.37	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.	NA	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	17
+NX_Q9H840	Gem-associated protein 7	131	14537	6.83	0	Nucleoplasm;Gem;Cytoplasm;Cytosol	NA	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.	NA	Belongs to the gemin-7 family.	RNA transport;snRNP Assembly	PE1	19
+NX_Q9H841	NIPA-like protein 2	368	40785	9.05	9	Membrane	NA	NA	NA	Belongs to the NIPA family.	Miscellaneous transport and binding events	PE1	8
+NX_Q9H845	Complex I assembly factor ACAD9, mitochondrial	621	68760	8.15	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 20	As part of the MCIA complex, primarily participates to the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852). This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852).	NA	Belongs to the acyl-CoA dehydrogenase family.	Complex I biogenesis	PE1	3
+NX_Q9H853	Putative tubulin-like protein alpha-4B	241	27551	7.71	0	Cytoskeleton	NA	NA	Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear.;Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold.	Belongs to the tubulin family.	Separation of Sister Chromatids;MHC class II antigen presentation;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE5	2
+NX_Q9H857	5'-nucleotidase domain-containing protein 2	520	60719	6.3	0	NA	NA	NA	NA	Belongs to the 5'(3')-deoxyribonucleotidase family.	NA	PE1	3
+NX_Q9H867	Protein-lysine methyltransferase METTL21D	229	25807	4.83	0	Cytoplasm;Cytosol	NA	Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.	NA	Belongs to the methyltransferase superfamily. METTL21 family.	Protein methylation	PE1	14
+NX_Q9H869	YY1-associated protein 1	796	87944	8.04	0	Nucleus;Cytoplasm;Nucleoplasm;Nucleolus	Grange syndrome	Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641).	NA	NA	NA	PE1	1
+NX_Q9H871	E3 ubiquitin-protein transferase RMND5A	391	43993	5.71	0	Nucleoplasm;Cytoplasm	NA	Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).	NA	NA	NA	PE1	2
+NX_Q9H875	PRKR-interacting protein 1	184	20997	9.78	0	Cytosol;Nucleus;Nucleolus;Cytoskeleton	NA	Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:30705154). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).	NA	Belongs to the PRKRIP1 family.	NA	PE1	7
+NX_Q9H892	Tetratricopeptide repeat protein 12	705	78756	5.5	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	11
+NX_Q9H898	Zinc finger matrin-type protein 4	229	25833	9.49	0	Nucleoplasm;Nucleus;Nucleolus	NA	NA	NA	NA	NA	PE1	8
+NX_Q9H8E8	Cysteine-rich protein 2-binding protein	782	88844	6.14	0	Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.	NA	NA	HATs acetylate histones	PE1	20
+NX_Q9H8G1	Zinc finger protein 430	570	66319	8.94	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9H8G2	Caspase activity and apoptosis inhibitor 1	361	38368	4.63	0	Cytoplasmic vesicle	NA	Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.	NA	NA	NA	PE1	9
+NX_Q9H8H0	Nucleolar protein 11	719	81124	5.74	0	Nucleolus	NA	Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.	NA	NA	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	17
+NX_Q9H8H2	Probable ATP-dependent RNA helicase DDX31	851	94087	10.01	0	Golgi apparatus;Nucleolus;Cytoplasmic vesicle	NA	Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed:23019224).	NA	Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.	NA	PE1	9
+NX_Q9H8H3	Methyltransferase-like protein 7A	244	28319	8.7	0	Membrane;Endoplasmic reticulum;Lipid droplet	NA	Probable methyltransferase.	NA	Belongs to the methyltransferase superfamily.	Neutrophil degranulation	PE1	12
+NX_Q9H8J5	MANSC domain-containing protein 1	431	46810	6.09	1	Membrane;Cytoplasmic vesicle;Golgi apparatus	NA	NA	NA	NA	NA	PE1	12
+NX_Q9H8K7	Uncharacterized protein C10orf88	445	49249	5.85	0	NA	NA	NA	NA	NA	NA	PE1	10
+NX_Q9H8L6	Multimerin-2	949	104409	5.56	0	Cytoplasmic vesicle;Extracellular matrix	NA	Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.	N- and O-glycosylated.	NA	NA	PE1	10
+NX_Q9H8M1	Coenzyme Q-binding protein COQ10 homolog B, mitochondrial	238	27071	9.67	0	Cytosol;Mitochondrion inner membrane	NA	Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).	NA	Belongs to the COQ10 family.	Respiratory electron transport	PE1	2
+NX_Q9H8M2	Bromodomain-containing protein 9	597	67000	5.81	0	Nucleoplasm	NA	Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).	NA	NA	NA	PE1	5
+NX_Q9H8M5	Metal transporter CNNM2	875	96623	6	3	Cytoplasmic vesicle;Cell membrane	Hypomagnesemia 6;Hypomagnesemia, seizures, and mental retardation 1	Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).	NA	Belongs to the ACDP family.	NA	PE1	10
+NX_Q9H8M7	Ubiquitin carboxyl-terminal hydrolase MINDY-3	445	49725	4.69	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.	NA	Belongs to the MINDY deubiquitinase family. FAM188 subfamily.	NA	PE1	10
+NX_Q9H8M9	Protein eva-1 homolog A	152	17470	6.44	1	Cytoplasmic vesicle;Lysosome membrane;Endoplasmic reticulum membrane;Cell membrane	NA	Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.	NA	Belongs to the EVA1 family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	2
+NX_Q9H8N7	Zinc finger protein 395	513	54939	7.17	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Plays a role in papillomavirus genes transcription.	NA	NA	NA	PE1	8
+NX_Q9H8P0	Polyprenol reductase	318	36521	9.49	6	Cytosol;Endoplasmic reticulum membrane;Cell membrane	Kahrizi syndrome;Congenital disorder of glycosylation 1Q	Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).	NA	Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.	Protein modification; protein glycosylation.;Steroid hormone biosynthesis;Synthesis of Dolichyl-phosphate;Androgen biosynthesis;Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ	PE1	4
+NX_Q9H8Q6	Putative uncharacterized protein encoded by HEXA-AS1	139	16103	9.14	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_Q9H8S5	Cyclin N-terminal domain-containing protein 2	307	33574	8.96	0	NA	NA	NA	NA	NA	NA	PE2	19
+NX_Q9H8S9	MOB kinase activator 1A	216	25080	6.45	0	NA	NA	Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.	Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.;MOB1A is phosphorylated by STK3	Belongs to the MOB1/phocein family.	Signaling by Hippo	PE1	2
+NX_Q9H8T0	AKT-interacting protein	292	33128	9.34	0	Cytoplasm;Cell membrane	NA	Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.	NA	Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.	NA	PE1	16
+NX_Q9H8U3	AN1-type zinc finger protein 3	227	25184	7.43	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	6
+NX_Q9H8V3	Protein ECT2	914	103505	7.77	0	Cytoplasm;Nucleus;Cleavage furrow;Cell junction;Nucleoplasm;Tight junction;Cytosol;Spindle;Midbody	NA	Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.	Phosphorylated by PLK1 in vitro. Hyperphosphorylated during the G2 phase of the cell cycle. Phosphorylation at Thr-373 occurs during the G2/M phase, relieves its auto-inhibition status and stimulates its GEF activity. Phosphorylation at Thr-444 in G2/M phase is required for subsequent binding with PLK1 and Rho exchange activation. Dephosphorylated at the time of cytokinesis. Phosphorylation at Thr-359 is required for its transformation activity in cancer cells.	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	3
+NX_Q9H8V8	Putative uncharacterized protein FLJ13197	135	14815	11.93	0	NA	NA	NA	NA	NA	NA	PE5	4
+NX_Q9H8W2	Putative uncharacterized protein encoded by LINC00472	130	13851	12.08	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_Q9H8W3	Protein FAM204A	233	27021	7.69	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	10
+NX_Q9H8W4	Pleckstrin homology domain-containing family F member 2	249	27798	8.55	0	Early endosome membrane;Endoplasmic reticulum;Endosome	NA	May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467).	NA	NA	NA	PE1	8
+NX_Q9H8W5	Tripartite motif-containing protein 45	580	64359	8.26	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.	NA	Belongs to the TRIM/RBCC family.	Interferon gamma signaling	PE1	1
+NX_Q9H8X2	Inositol-pentakisphosphate 2-kinase	491	56017	8.67	0	Cytoplasm;Cytosol;Nucleus	NA	Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.	NA	Belongs to the IPK1 type 2 family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of IPs in the nucleus;Synthesis of pyrophosphates in the cytosol	PE1	9
+NX_Q9H8X3	Putative uncharacterized protein LINC00574	128	13648	8.17	0	NA	NA	NA	NA	NA	NA	PE5	6
+NX_Q9H8X9	Probable palmitoyltransferase ZDHHC11	412	45975	8.65	4	Membrane	NA	NA	NA	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	5
+NX_Q9H8Y1	Vertnin	702	78260	9.17	0	Nucleoplasm	NA	NA	NA	Belongs to the vertnin family.	NA	PE1	14
+NX_Q9H8Y5	Ankyrin repeat and zinc finger domain-containing protein 1	726	80927	8.69	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity).	NA	Belongs to the ANKZF1/VMS1 family.	NA	PE1	2
+NX_Q9H8Y8	Golgi reassembly-stacking protein 2	452	47145	4.73	0	Golgi apparatus;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262).	Phosphorylated in mitotic cells (PubMed:11408587). ER stress-induced phosphorylation at Ser-441 induces monomerization and subsequent relocalization from Golgi to ER which is essential for mediating unconventional (ER/Golgi-independent) trafficking of CFTR to the cell membrane (PubMed:21884936, PubMed:27062250).;Myristoylated (PubMed:11101516). Myristoylation is essential for the Golgi targeting (By similarity).;Palmitoylated.	Belongs to the GORASP family.	Golgi Cisternae Pericentriolar Stack Reorganization	PE1	2
+NX_Q9H900	Protein zwilch homolog	591	67214	5.85	0	Kinetochore	NA	Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).	NA	Belongs to the ZWILCH family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	15
+NX_Q9H902	Receptor expression-enhancing protein 1	201	22255	9.52	2	Mitochondrion membrane;Endoplasmic reticulum;Membrane	Neuronopathy, distal hereditary motor, 5B;Spastic paraplegia 31, autosomal dominant	Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (PubMed:20200447). May play a role in long-term axonal maintenance (PubMed:24478229).	NA	Belongs to the DP1 family.	Olfactory Signaling Pathway	PE1	2
+NX_Q9H903	Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2	347	37315	9.38	0	Cytoplasm;Mitochondrion inner membrane	NA	NA	NA	Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.	One-carbon metabolism; tetrahydrofolate interconversion.;One carbon pool by folate;Metabolic pathways;Metabolism of folate and pterines	PE1	4
+NX_Q9H910	Jupiter microtubule associated homolog 2	190	20063	9.3	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	NA	NA	Belongs to the JUPITER family.	NA	PE1	16
+NX_Q9H920	RING finger protein 121	327	37882	6.6	6	Membrane;Nucleoplasm;Golgi apparatus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the RNF121 family.	NA	PE1	11
+NX_Q9H930	Nuclear body protein SP140-like protein	580	67005	8.79	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	2
+NX_Q9H936	Mitochondrial glutamate carrier 1	323	34470	9.42	6	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	Epileptic encephalopathy, early infantile, 3	Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Organic anion transporters	PE1	11
+NX_Q9H939	Proline-serine-threonine phosphatase-interacting protein 2	334	38858	8.72	0	Cytoplasm;Mitochondrion;Cell membrane;Membrane;Nucleoplasm	NA	Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).	Phosphorylated on tyrosine.	NA	NA	PE1	18
+NX_Q9H944	Mediator of RNA polymerase II transcription subunit 20	212	23222	6.42	0	Nucleoplasm;Centrosome;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 20 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	6
+NX_Q9H963	Putative zinc finger protein 702	129	15019	9.39	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE5	19
+NX_Q9H967	WD repeat-containing protein 76	626	69769	9.35	0	Nucleus;Nucleolus	NA	Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.	NA	Belongs to the WD repeat DDB2/WDR76 family.	NA	PE1	15
+NX_Q9H972	Uncharacterized protein C14orf93	538	58697	5.71	0	Nucleoplasm;Secreted;Cell membrane	NA	NA	NA	NA	NA	PE1	14
+NX_Q9H974	Queuine tRNA-ribosyltransferase accessory subunit 2	415	46713	6.36	0	Mitochondrion outer membrane;Cytoplasm;Nucleoplasm;Cytoskeleton	NA	Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).	NA	Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.	tRNA modification in the nucleus and cytosol	PE1	3
+NX_Q9H977	WD repeat-containing protein 54	334	35891	5.77	0	Cytoplasmic vesicle;Cytosol;Vesicle	NA	When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation.	Cross-linked to tightly form both dimers and trimers by TGM2. Cross-linking enhances the activation of EGF receptor-mediated signaling pathway (PubMed:30458214). Cross-linking is inhibited by EGF (PubMed:30458214).;Ubiquitinated. EGF increases ubiquitination.	NA	NA	PE1	2
+NX_Q9H981	Actin-related protein 8	624	70484	7.86	0	Nucleoplasm;Centrosome;Nucleus;Chromosome	NA	Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.;Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.	NA	Belongs to the actin family. ARP8 subfamily.	DNA Damage Recognition in GG-NER;UCH proteinases	PE1	3
+NX_Q9H987	Synaptopodin 2-like protein	977	102481	9.77	0	Cytosol;Cell junction;Nucleus speckle;Cytoskeleton	NA	Actin-associated protein that may play a role in modulating actin-based shape.	NA	Belongs to the synaptopodin family.	NA	PE1	10
+NX_Q9H992	E3 ubiquitin-protein ligase MARCH7	704	78051	6.32	0	Cytosol;Cell membrane	NA	E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356).	NA	NA	Protein modification; protein ubiquitination.	PE1	2
+NX_Q9H993	Damage-control phosphatase ARMT1	441	51172	5.48	0	Nucleoplasm;Cytosol;Nucleus	NA	Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (PubMed:25732820). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (PubMed:25732820).	Automethylated.	Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.	NA	PE1	6
+NX_Q9H999	Pantothenate kinase 3	370	41094	6.13	0	Golgi apparatus;Nucleoplasm;Cytoplasm	NA	Plays a role in the physiological regulation of the intracellular CoA concentration.	NA	Belongs to the type II pantothenate kinase family.	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.;Pantothenate and CoA biosynthesis;Metabolic pathways;Coenzyme A biosynthesis	PE1	5
+NX_Q9H9A5	CCR4-NOT transcription complex subunit 10	744	82310	7.95	0	Cytoplasm;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.	NA	Belongs to the CNOT10 family.	RNA degradation;Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	3
+NX_Q9H9A6	Leucine-rich repeat-containing protein 40	602	68250	6.04	0	Nucleolus	NA	NA	NA	NA	NA	PE1	1
+NX_Q9H9A7	RecQ-mediated genome instability protein 1	625	70144	4.86	0	Nucleoplasm;Nucleus	NA	Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.	NA	Belongs to the RMI1 family.	Fanconi anemia pathway;G2/M DNA damage checkpoint;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	9
+NX_Q9H9B1	Histone-lysine N-methyltransferase EHMT1	1298	141466	5.5	0	Nucleoplasm;Nucleus;Chromosome	Kleefstra syndrome 1	Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	Lysine degradation;PKMTs methylate histone lysines;Senescence-Associated Secretory Phenotype (SASP);Regulation of TP53 Activity through Methylation;Transcriptional Regulation by E2F6	PE1	9
+NX_Q9H9B4	Sideroflexin-1	322	35619	9.22	5	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). Transports both D-serine and L-serine (PubMed:30442778). Also able to transport other amino-acids, such as alanine (PubMed:30442778). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity).	NA	Belongs to the sideroflexin family.	NA	PE1	5
+NX_Q9H9C1	Spermatogenesis-defective protein 39 homolog	493	57005	6.94	0	Cytoplasm;Recycling endosome;Early endosome;Late endosome;Cytoplasmic vesicle	Arthrogryposis, renal dysfunction and cholestasis syndrome 2	Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity).	NA	Belongs to the SPE39 family.	NA	PE1	14
+NX_Q9H9D4	Zinc finger protein 408	720	78439	6.88	0	Cytosol;Centriolar satellite;Nucleus	Vitreoretinopathy, exudative 6;Retinitis pigmentosa 72	May be involved in transcriptional regulation.	NA	NA	NA	PE1	11
+NX_Q9H9E1	Ankyrin repeat family A protein 2	313	34272	4.99	0	Cell membrane;Cell junction;Membrane;Nucleoplasm;Cytoskeleton	NA	May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity).	ANKRA2 is phosphorylated by NEK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	NA	PE1	5
+NX_Q9H9E3	Conserved oligomeric Golgi complex subunit 4	785	89083	5.09	0	Golgi apparatus;Cytoplasmic vesicle;Cytosol;Golgi apparatus membrane	Congenital disorder of glycosylation 2J;Saul-Wilson syndrome	Required for normal Golgi function (PubMed:19536132, PubMed:30290151). Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132).	NA	Belongs to the COG4 family.	Intra-Golgi traffic;COPI-mediated anterograde transport;Retrograde transport at the Trans-Golgi-Network	PE1	16
+NX_Q9H9F9	Actin-related protein 5	607	68297	5.17	0	Cytoplasm;Nucleus	NA	Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.	NA	Belongs to the actin family. ARP5 subfamily.	DNA Damage Recognition in GG-NER;UCH proteinases	PE1	20
+NX_Q9H9G7	Protein argonaute-3	860	97360	9.26	0	Nucleoplasm;Cytosol;P-body	NA	Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713).	NA	Belongs to the argonaute family. Ago subfamily.	MAPK6/MAPK4 signaling;Oxidative Stress Induced Senescence;MicroRNA (miRNA) biogenesis;Pre-NOTCH Transcription and Translation;Small interfering RNA (siRNA) biogenesis;TP53 Regulates Metabolic Genes;Ca2+ pathway;Post-transcriptional silencing by small RNAs;Oncogene Induced Senescence;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of RUNX1 Expression and Activity;Regulation of PTEN mRNA translation;Competing endogenous RNAs (ceRNAs) regulate PTEN translation;Estrogen-dependent gene expression;Transcriptional Regulation by MECP2;Regulation of MECP2 expression and activity	PE1	1
+NX_Q9H9H4	Vacuolar protein sorting-associated protein 37B	285	31307	6.78	0	Late endosome membrane	NA	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.	NA	Belongs to the VPS37 family.	Endocytosis;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	12
+NX_Q9H9H5	MAP6 domain-containing protein 1	199	21005	10.08	0	Golgi apparatus;Cytosol;Cytoskeleton	NA	May have microtubule-stabilizing activity.	Palmitoylated. Palmitoylation enhances association with microtubules.	Belongs to the STOP family.	NA	PE1	3
+NX_Q9H9J2	39S ribosomal protein L44, mitochondrial	332	37535	8.65	0	Nucleoplasm;Mitochondrion;Cell membrane	Combined oxidative phosphorylation deficiency 16	Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.	NA	Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	2
+NX_Q9H9J4	Ubiquitin carboxyl-terminal hydrolase 42	1324	145392	8.87	0	Nucleoplasm	NA	Deubiquitinating enzyme which may play an important role during spermatogenesis.	NA	Belongs to the peptidase C19 family.	Ub-specific processing proteases	PE1	7
+NX_Q9H9K5	Endogenous retroviral envelope protein HEMO	563	63547	8.16	1	Nucleoplasm;Cytosol;Secreted;Cell membrane	NA	Endogenous envelope proteins originate from retroviral envelope proteins, which mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.	N-glycosylated.;Endogenous retroviral envelope protein HEMO: Cleaved by some metalloproteinase at 432-Gln-Arg-433 (mainly) or 433-Arg-Gln-434, leading to release the secreted form (Endogenous retroviral envelope protein HEMO, secreted form) in the extracellular medium.	Belongs to the gamma type-C retroviral envelope protein family.	NA	PE1	4
+NX_Q9H9L3	Interferon-stimulated 20 kDa exonuclease-like 2	353	39154	9.94	0	Nucleoplasm;Nucleolus	NA	3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group.	NA	NA	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	1
+NX_Q9H9L4	KAT8 regulatory NSL complex subunit 2	492	55042	6.18	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.	NA	NA	HATs acetylate histones	PE1	12
+NX_Q9H9L7	Akirin-1	192	21867	8.91	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis. May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway.	NA	Belongs to the akirin family.	NA	PE1	1
+NX_Q9H9P2	Chondrolectin	273	30431	6.38	1	Membrane;Cytoplasm;Endoplasmic reticulum membrane;Endoplasmic reticulum	NA	May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance.	N-glycosylated.	NA	NA	PE1	21
+NX_Q9H9P5	Putative E3 ubiquitin-protein ligase UNKL	680	73828	8.42	0	Cytoplasm;Cytosol;Nucleus	NA	May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.	Is ubiquitinated in the C-terminal. Ubiquitination is enhanced by activated RAC1. The presence of the RING finger domain is not essential for ubiquitination to occur.	Belongs to the unkempt family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	16
+NX_Q9H9P8	L-2-hydroxyglutarate dehydrogenase, mitochondrial	463	50316	8.45	0	Mitochondrion	L-2-hydroxyglutaric aciduria	NA	NA	Belongs to the L2HGDH family.	Butanoate metabolism;Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	PE1	14
+NX_Q9H9Q2	COP9 signalosome complex subunit 7b	264	29622	5.83	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.	NA	Belongs to the CSN7/EIF3M family. CSN7 subfamily.	Formation of TC-NER Pre-Incision Complex;DNA Damage Recognition in GG-NER;Cargo recognition for clathrin-mediated endocytosis;Neddylation	PE1	2
+NX_Q9H9Q4	Non-homologous end-joining factor 1	299	33337	5.65	0	Nucleoplasm;Nucleolus;Nucleus	Severe combined immunodeficiency due to NHEJ1 deficiency	DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17470781). Binds DNA in a length-dependent manner (PubMed:17317666).	NA	Belongs to the XLF family.	Nonhomologous End-Joining (NHEJ)	PE1	2
+NX_Q9H9R9	Dysbindin domain-containing protein 1	158	17042	4.26	0	Cytosol;Nucleus speckle	NA	NA	NA	Belongs to the dysbindin family.	NA	PE1	16
+NX_Q9H9S0	Homeobox protein NANOG	305	34620	6.32	0	Nucleus	NA	Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.	NANOG is phosphorylated by PRKCE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the Nanog homeobox family.	Transcriptional regulation of pluripotent stem cells;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation;Interleukin-4 and Interleukin-13 signaling	PE1	12
+NX_Q9H9S3	Protein transport protein Sec61 subunit alpha isoform 2	476	52248	8.31	10	Endoplasmic reticulum membrane	NA	Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).	NA	Belongs to the SecY/SEC61-alpha family.	Protein export;Protein processing in endoplasmic reticulum;Phagosome;Vibrio cholerae infection;ER-Phagosome pathway;SRP-dependent cotranslational protein targeting to membrane	PE1	10
+NX_Q9H9S4	Calcium-binding protein 39-like	337	39088	8.49	0	Cytoplasmic vesicle	NA	Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).	NA	Belongs to the Mo25 family.	mTOR signaling pathway;Energy dependent regulation of mTOR by LKB1-AMPK	PE1	13
+NX_Q9H9S5	Fukutin-related protein	495	54568	7.05	1	Golgi apparatus;Cytoplasm;Secreted;Rough endoplasmic reticulum;Nucleoplasm;Golgi apparatus membrane;Cytosol;Sarcolemma	Muscular dystrophy-dystroglycanopathy limb-girdle C5;Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A5;Muscular dystrophy-dystroglycanopathy congenital with or without mental retardation B5	Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:25279699, PubMed:26923585, PubMed:29477842). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:25279699, PubMed:26923585, PubMed:29477842).	N-glycosylated.	Belongs to the LicD transferase family.	Protein modification; protein glycosylation.	PE1	19
+NX_Q9H9T3	Elongator complex protein 3	547	62259	9.04	0	Cytoplasm;Cytosol;Nucleus	Amyotrophic lateral sclerosis	Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576, PubMed:15902492, PubMed:16713582). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (PubMed:29415125). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity).	NA	Belongs to the ELP3 family.	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.;HATs acetylate histones	PE1	8
+NX_Q9H9V4	RING finger protein 122	155	17475	8.21	1	Endoplasmic reticulum;Golgi apparatus;Membrane	NA	May induce necrosis and apoptosis. May play a role in cell viability.	NA	NA	NA	PE1	8
+NX_Q9H9V9	2-oxoglutarate and iron-dependent oxygenase JMJD4	463	52493	5.79	0	Cytoplasmic vesicle;Cytoplasm;Cell membrane	NA	Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1.	NA	NA	NA	PE1	1
+NX_Q9H9Y2	Ribosome production factor 1	349	40111	10.01	0	Nucleolus	NA	May be required for ribosome biogenesis.	NA	NA	NA	PE1	1
+NX_Q9H9Y4	GPN-loop GTPase 2	310	34561	5.07	0	NA	NA	Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.	NA	Belongs to the GPN-loop GTPase family.	NA	PE1	1
+NX_Q9H9Y6	DNA-directed RNA polymerase I subunit RPA2	1135	128229	8.07	0	Cytosol;Nucleolus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).	NA	Belongs to the RNA polymerase beta chain family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;B-WICH complex positively regulates rRNA expression	PE1	2
+NX_Q9H9Z2	Protein lin-28 homolog A	209	22743	8.35	0	Cytoplasm;Stress granule;Nucleolus;Rough endoplasmic reticulum;P-body;Cytosol	NA	RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 AND tut7 uridylyltransferaseS. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity).	NA	Belongs to the lin-28 family.	Transcriptional regulation of pluripotent stem cells	PE1	1
+NX_Q9HA38	Zinc finger matrin-type protein 3	289	32059	9.12	0	Nucleoplasm;Nucleus;Nucleolus	NA	Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.	NA	NA	NA	PE1	3
+NX_Q9HA47	Uridine-cytidine kinase 1	277	31435	6.8	0	Nucleoplasm	NA	Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.	NA	Belongs to the uridine kinase family.	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.;Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.;Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine salvage	PE1	9
+NX_Q9HA64	Ketosamine-3-kinase	309	34412	6.84	0	Cytoplasm;Nucleoplasm	NA	Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively (PubMed:14633848, PubMed:15137908). Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:14633848, PubMed:15137908). Not able to phosphorylate fructoselysine (PubMed:14633848).	NA	Belongs to the fructosamine kinase family.	Gamma carboxylation, hypusine formation and arylsulfatase activation	PE1	17
+NX_Q9HA65	TBC1 domain family member 17	648	72728	5.05	0	Autophagosome	NA	Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known.	NA	NA	TBC/RABGAPs	PE1	19
+NX_Q9HA72	Calcium homeostasis modulator protein 2	323	36175	7.61	4	Membrane;Nucleoplasm;Cytosol;Mitochondrion	NA	Pore-forming subunit of a voltage-gated ion channel.	NA	Belongs to the CALHM family.	NA	PE1	10
+NX_Q9HA77	Probable cysteine--tRNA ligase, mitochondrial	564	62224	8.58	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion	Combined oxidative phosphorylation deficiency 27	NA	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	13
+NX_Q9HA82	Ceramide synthase 4	394	46399	9.19	6	Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum membrane;Cytoplasmic vesicle	NA	Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor.	Phosphorylated at the C-terminus by CK2.;N-glycosylated.	NA	Lipid metabolism; sphingolipid metabolism.;Sphingolipid de novo biosynthesis	PE1	19
+NX_Q9HA90	EF-hand and coiled-coil domain-containing protein 1	598	65701	5.44	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_Q9HA92	Radical S-adenosyl methionine domain-containing protein 1, mitochondrial	442	48714	7.7	0	Nucleoplasm;Cytosol;Mitochondrion;Cell membrane	NA	May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity (Probable). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).	NA	Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.	NA	PE1	17
+NX_Q9HAA7	Putative uncharacterized protein FLJ11871	133	14475	9.61	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_Q9HAB3	Solute carrier family 52, riboflavin transporter, member 2	445	45777	6.73	11	Cell membrane	Brown-Vialetto-Van Laere syndrome 2	Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:20463145, PubMed:22864630, PubMed:23243084, PubMed:24253200, PubMed:27702554). Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145). May also act as a receptor for 4-hydroxybutyrate (Probable).;(Microbial infection) In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).	NA	Belongs to the riboflavin transporter family.	Vitamin B2 (riboflavin) metabolism	PE1	8
+NX_Q9HAB8	Phosphopantothenate--cysteine ligase	311	34005	6.26	0	Nucleoplasm;Mitochondrion;Nucleolus	Cardiomyopathy, dilated 2C	Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11923312, PubMed:12906824, PubMed:29754768). Has a preference for ATP over CTP as a cosubstrate (PubMed:11923312).	NA	Belongs to the PPC synthetase family.	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.;Pantothenate and CoA biosynthesis;Metabolic pathways;Coenzyme A biosynthesis	PE1	1
+NX_Q9HAC7	Succinate--hydroxymethylglutarate CoA-transferase	445	48462	8.54	0	Mitochondrion	Glutaric aciduria 3	Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.	NA	Belongs to the CoA-transferase III family.	NA	PE1	7
+NX_Q9HAC8	Ubiquitin domain-containing protein 1	227	25938	7.69	0	Cytoplasmic vesicle;Cytosol;Cell membrane	NA	May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.	NA	NA	NA	PE1	10
+NX_Q9HAD4	WD repeat-containing protein 41	459	51728	5.25	0	Golgi apparatus;Nucleoplasm;Cytosol;Cytoplasm	NA	Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).	NA	NA	NA	PE1	5
+NX_Q9HAE3	EF-hand calcium-binding domain-containing protein 1	211	24488	4.91	0	Nucleoplasm;Cell membrane	NA	NA	NA	NA	NA	PE1	8
+NX_Q9HAF1	Chromatin modification-related protein MEAF6	191	21635	9.32	0	Nucleolus;Kinetochore	NA	Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.	NA	Belongs to the EAF6 family.	HATs acetylate histones;Regulation of TP53 Activity through Acetylation	PE1	1
+NX_Q9HAH1	Zinc finger protein 556	456	51581	9.94	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9HAH7	Probable fibrosin-1	460	48388	9.96	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	16
+NX_Q9HAI6	Protein CXorf21	301	33894	4.94	0	Cytoplasmic vesicle;Nucleoplasm;Cytoplasm;Nucleus	NA	Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes. May be involved in endolysosomal-dependent immune responses.	NA	NA	NA	PE1	X
+NX_Q9HAJ7	Histone deacetylase complex subunit SAP30L	183	20877	9.43	0	Nucleolus	NA	Functions as transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3.;Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676).;Functions as transcription repressor; its activity is marginally lower than that of isoform 1.	NA	Belongs to the SAP30 family.	NoRC negatively regulates rRNA expression;HDACs deacetylate histones	PE1	5
+NX_Q9HAK2	Transcription factor COE2	575	62650	9.21	0	Nucleus	NA	Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).	NA	Belongs to the COE family.	NA	PE1	8
+NX_Q9HAN9	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1	279	31932	8.98	0	Nucleoplasm;Nucleus	Leber congenital amaurosis 9	Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. The pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults (By similarity).	NA	Belongs to the eukaryotic NMN adenylyltransferase family.	Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.;Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.;Nicotinate and nicotinamide metabolism;Metabolic pathways;Nicotinate metabolism	PE1	1
+NX_Q9HAP2	MLX-interacting protein	919	101185	8.61	0	Mitochondrion outer membrane;Cytoplasm;Nucleus	NA	Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.	NA	NA	NA	PE1	12
+NX_Q9HAP6	Protein lin-7 homolog B	207	22896	8.71	0	Cell membrane;Basolateral cell membrane;Cell junction;Tight junction;Postsynaptic density membrane	NA	Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).	NA	Belongs to the lin-7 family.	RHO GTPases Activate Rhotekin and Rhophilins;Dopamine Neurotransmitter Release Cycle;Neurexins and neuroligins;Assembly and cell surface presentation of NMDA receptors	PE1	19
+NX_Q9HAQ2	Kinesin-like protein KIF9	790	89986	6.71	0	Cytoskeleton	NA	NA	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	3
+NX_Q9HAR2	Adhesion G protein-coupled receptor L3	1447	161812	5.99	7	Cell junction;Axon;Cell membrane	NA	Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.	O-glycosylated (major) and N-glycosylated.;Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.	NA	PE1	4
+NX_Q9HAS0	Protein Njmu-R1	396	44622	4.98	0	trans-Golgi network;Cytoplasmic vesicle;Cytosol;Golgi apparatus	NA	As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis.	NA	NA	NA	PE1	17
+NX_Q9HAS3	Solute carrier family 28 member 3	691	76930	7.56	13	Endoplasmic reticulum membrane;Cell membrane	NA	Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine.	NA	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	PE1	9
+NX_Q9HAT0	Ropporin-1A	212	23893	5.52	0	Flagellum	NA	Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.	Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.	Belongs to the ropporin family.	RHO GTPases Activate Rhotekin and Rhophilins	PE1	3
+NX_Q9HAT1	Protein ERGIC-53-like	526	57129	7.73	1	Endoplasmic reticulum-Golgi intermediate compartment membrane	NA	NA	NA	NA	Protein processing in endoplasmic reticulum;COPII-mediated vesicle transport;Cargo concentration in the ER	PE2	15
+NX_Q9HAT2	Sialate O-acetylesterase	523	58315	6.93	0	Secreted;Lysosome	Autoimmune disease 6	Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.	NA	NA	NA	PE1	11
+NX_Q9HAT8	E3 ubiquitin-protein ligase pellino homolog 2	420	46435	6.97	0	Nucleoplasm;Nucleolus;Cytoskeleton	NA	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.	Phosphorylated by IRAK1 and IRAK4 enhancing its E3 ligase activity.;PELI2 is phosphorylated by IRAK4 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the pellino family.	Protein modification; protein ubiquitination.;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Interleukin-1 signaling	PE1	14
+NX_Q9HAU0	Pleckstrin homology domain-containing family A member 5	1116	127464	7.2	0	Nucleoplasm;Cytoplasm;Cytosol	NA	NA	NA	NA	Synthesis of PIPs at the plasma membrane	PE1	12
+NX_Q9HAU4	E3 ubiquitin-protein ligase SMURF2	748	86196	8.18	0	Cytoplasm;Nucleus speckle;Cell membrane;Membrane raft;Nucleus	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.	Auto-ubiquitinated and ubiquitinated in the presence of RNF11 and UBE2D1. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome.	NA	Protein modification; protein ubiquitination.;Asymmetric localization of PCP proteins;Degradation of AXIN;Hedgehog 'on' state;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Signaling by BMP;Downregulation of TGF-beta receptor signaling;Ub-specific processing proteases;Regulation of RUNX3 expression and activity	PE1	17
+NX_Q9HAU5	Regulator of nonsense transcripts 2	1272	147810	5.5	0	Cytoplasm;Cytosol;Perinuclear region	NA	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.	NA	NA	RNA transport;mRNA surveillance pathway;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Regulation of expression of SLITs and ROBOs	PE1	10
+NX_Q9HAU6	Putative translationally-controlled tumor protein-like protein TPT1P8	139	15994	5.42	0	NA	NA	NA	NA	Belongs to the TCTP family.	NA	PE5	8
+NX_Q9HAU8	Aminopeptidase RNPEPL1	725	80000	5.06	0	Nucleoplasm;Nucleolus	NA	Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine.	NA	Belongs to the peptidase M1 family.	NA	PE1	2
+NX_Q9HAV0	Guanine nucleotide-binding protein subunit beta-4	340	37567	5.59	0	NA	Charcot-Marie-Tooth disease, dominant, intermediate type, F	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the WD repeat G protein beta family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	3
+NX_Q9HAV4	Exportin-5	1204	136311	5.56	0	Cytoplasm;Nucleoplasm;Nucleus	NA	(Microbial infection) Mediates the nuclear export of adenovirus VA1 dsRNA.;Mediates the nuclear export of micro-RNA precursors, which form short hairpins (PubMed:14681208, PubMed:14631048, PubMed:15613540). Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs (PubMed:19965479). Binding is dependent on Ran-GTP (PubMed:19965479).;Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.	NA	Belongs to the exportin family.	RNA transport;MicroRNA (miRNA) biogenesis	PE1	6
+NX_Q9HAV5	Tumor necrosis factor receptor superfamily member 27	297	32759	4.91	1	Membrane;Cell junction	NA	Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.	NA	NA	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	X
+NX_Q9HAV7	GrpE protein homolog 1, mitochondrial	217	24279	8.24	0	Mitochondrion matrix;Mitochondrion	NA	Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (PubMed:11311562).	NA	Belongs to the GrpE family.	Mitochondrial protein import	PE1	4
+NX_Q9HAW0	Transcription factor IIIB 50 kDa subunit	419	46533	8.29	0	Nucleolus;Nucleus	NA	General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071).	In response to oxidative stress, Cys-361 is reversibly oxidized to cysteine sulfenic acid. Oxidation of Cys-361 impairs formation of a ternary complex with TBP and DNA and down-regulates expression of target genes in response to oxidative stress.	Belongs to the TFIIB family.	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	8
+NX_Q9HAW4	Claspin	1339	151094	4.74	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.	Phosphorylated. Undergoes ATR-dependent phosphorylation by CHEK1 during activation of DNA replication or damage checkpoints. Phosphorylation by CSNK1G1/CK1 promotes CHEK1 binding.;Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) during G1 phase, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Following DNA damage, it is deubiquitinated by USP28 in G2 phase, preventing its degradation.	Belongs to the claspin family.	Activation of ATR in response to replication stress;Apoptotic cleavage of cellular proteins;Processing of DNA double-strand break ends;Ub-specific processing proteases	PE1	1
+NX_Q9HAW7	UDP-glucuronosyltransferase 1-7	530	59819	7.88	1	Endoplasmic reticulum membrane;Microsome	NA	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.;Lacks transferase activity but acts as a negative regulator of isoform 1.	UGT1A7 is phosphorylated by PRKCE (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	2
+NX_Q9HAW8	UDP-glucuronosyltransferase 1-10	530	59810	6.88	1	Endoplasmic reticulum membrane;Microsome	NA	Lacks transferase activity but acts as a negative regulator of isoform 1.;UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	2
+NX_Q9HAW9	UDP-glucuronosyltransferase 1-8	530	59742	7.6	1	Endoplasmic reticulum membrane;Microsome	NA	Lacks transferase activity but acts as a negative regulator of isoform 1.;UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	2
+NX_Q9HAY2	Melanoma-associated antigen F1	307	35222	9.71	0	Cytoskeleton	NA	Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed:29225034).	NA	NA	NA	PE1	3
+NX_Q9HAY6	Beta,beta-carotene 15,15'-dioxygenase	547	62637	6.21	0	Centriolar satellite;Cytoskeleton	Hypercarotenemia and vitamin A deficiency, autosomal dominant	Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.	NA	Belongs to the carotenoid oxygenase family.	Cofactor metabolism; retinol metabolism.;Retinol metabolism;Metabolic pathways;Retinoid metabolism and transport	PE1	16
+NX_Q9HAZ1	Dual specificity protein kinase CLK4	481	57492	8.92	0	Nucleus;Cytoskeleton	NA	Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.	Autophosphorylates on all three types of residues.;Autophosphorylated (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.	NA	PE1	5
+NX_Q9HAZ2	Histone-lysine N-methyltransferase PRDM16	1276	140251	5.81	0	Cytoplasm;Nucleoplasm;Nucleus	Left ventricular non-compaction 8;Cardiomyopathy, dilated 1LL	Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872).;Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980).	NA	Belongs to the PRDM16 family.	PKMTs methylate histone lysines	PE1	1
+NX_Q9HB03	Elongation of very long chain fatty acids protein 3	270	31500	9.55	7	Cytoplasmic vesicle;Cytosol;Endoplasmic reticulum membrane	NA	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.	N-Glycosylated.	Belongs to the ELO family. ELOVL3 subfamily.	Lipid metabolism; polyunsaturated fatty acid biosynthesis.;Fatty acid elongation;Synthesis of very long-chain fatty acyl-CoAs;Linoleic acid (LA) metabolism;alpha-linolenic acid (ALA) metabolism	PE1	10
+NX_Q9HB07	UPF0160 protein MYG1, mitochondrial	376	42449	6.19	0	Nucleoplasm;Mitochondrion;Nucleus	NA	NA	NA	Belongs to the UPF0160 (MYG1) family.	NA	PE1	12
+NX_Q9HB09	Bcl-2-like protein 12	334	36821	9.45	0	Cytoplasmic vesicle;Cell membrane	NA	NA	NA	Belongs to the Bcl-2 family.	NA	PE1	19
+NX_Q9HB14	Potassium channel subfamily K member 13	408	45391	8.73	4	Membrane;Cell junction;Nucleus speckle	NA	Potassium channel displaying weak inward rectification in symmetrical K(+) solution.	NA	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Tandem pore domain halothane-inhibited K+ channel (THIK);Phase 4 - resting membrane potential	PE1	14
+NX_Q9HB15	Potassium channel subfamily K member 12	430	46889	9.89	4	Membrane	NA	Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).	NA	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Phase 4 - resting membrane potential	PE1	2
+NX_Q9HB19	Pleckstrin homology domain-containing family A member 2	425	47255	8.92	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).	NA	NA	Synthesis of PIPs at the plasma membrane	PE1	8
+NX_Q9HB20	Pleckstrin homology domain-containing family A member 3	300	33861	6.19	0	Golgi apparatus;trans-Golgi network membrane	NA	Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).	NA	NA	Synthesis of PIPs at the plasma membrane	PE1	2
+NX_Q9HB21	Pleckstrin homology domain-containing family A member 1	404	45553	8.77	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.	NA	NA	Synthesis of PIPs at the plasma membrane	PE1	10
+NX_Q9HB29	Interleukin-1 receptor-like 2	575	65405	7.24	1	Membrane	NA	Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.	NA	Belongs to the interleukin-1 receptor family.	Interleukin-36 pathway;Interleukin-38 signaling	PE1	2
+NX_Q9HB31	Homeobox protein SEBOX	190	20398	8.91	0	Nucleus	NA	Probable transcription factor involved in the control of specification of mesoderm and endoderm.	NA	Belongs to the paired homeobox family.	NA	PE2	17
+NX_Q9HB40	Retinoid-inducible serine carboxypeptidase	452	50831	5.6	0	Golgi apparatus;Secreted	NA	May be involved in vascular wall and kidney homeostasis.	NA	Belongs to the peptidase S10 family.	NA	PE1	17
+NX_Q9HB55	Cytochrome P450 3A43	503	57670	8.27	0	Microsome membrane;Endoplasmic reticulum membrane	NA	Exhibits low testosterone 6-beta-hydroxylase activity.	NA	Belongs to the cytochrome P450 family.	Steroid hormone biosynthesis;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Miscellaneous substrates;Xenobiotics	PE1	7
+NX_Q9HB58	Sp110 nuclear body protein	689	78396	9.1	0	Nucleoplasm;Nucleus	Hepatic venoocclusive disease with immunodeficiency	Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).	Phosphorylated (isoform 2).	NA	NA	PE1	2
+NX_Q9HB63	Netrin-4	628	70071	8.44	0	Basement membrane	NA	May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.	NA	NA	Axon guidance;Netrin-1 signaling;Non-integrin membrane-ECM interactions	PE1	12
+NX_Q9HB65	RNA polymerase II elongation factor ELL3	397	45361	5.73	0	Nucleoplasm;Nucleolus;Nucleus	NA	Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968).	NA	Belongs to the ELL/occludin family.	RNA polymerase II transcribes snRNA genes	PE1	15
+NX_Q9HB71	Calcyclin-binding protein	228	26210	8.28	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).	Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.	NA	Wnt signaling pathway	PE1	1
+NX_Q9HB75	p53-induced death domain-containing protein 1	910	99712	6.01	0	Golgi apparatus;Cytoplasm;Cytosol;Nucleus	NA	Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:17159900). Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900).	Undergoes autoproteolytic processing whose extent either directs cells towards survival or apoptotic pathways (PubMed:17159900). Autoproteolytically cleaved into two main fragments PIDD-N and PIDD-C (PubMed:17159900). PIDD-C can be further processed into PIDD-CC, a processing which is enhanced by DNA damage (PubMed:17159900). The cleavage producing PIDD-C is required for translocation of PIDD1 to the nucleus upon DNA damage and activation of NF-kappa-B (PubMed:17159900). PIDD-CC mediates the interaction with CRADD and the cleavage producing PIDD-CC is required for the activation of CASP2 (PubMed:17159900). PIDD-N remains associated with PIDD-C and PIDD-CC after cleavage (PubMed:17159900).	NA	p53 signaling pathway;TP53 Regulates Transcription of Caspase Activators and Caspases	PE1	11
+NX_Q9HB89	Neuromedin-U receptor 1	426	47351	9.06	7	Cell membrane	NA	Receptor for the neuromedin-U and neuromedin-S neuropeptides.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Peptide ligand-binding receptors;G alpha (q) signalling events	PE2	2
+NX_Q9HB90	Ras-related GTP-binding protein C	399	44224	4.94	0	Cytoplasm;Nucleoplasm;Lysosome;Cytoplasmic vesicle;Nucleus	NA	Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.	NA	Belongs to the GTR/RAG GTP-binding protein family.	NA	PE1	1
+NX_Q9HB96	Fanconi anemia group E protein	536	58711	5.17	0	Nucleoplasm;Nucleus	Fanconi anemia complementation group E	As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.	Ubiquitinated. Phosphorylation by CHEK1 induces polyubiquitination and degradation.;Phosphorylated. Phosphorylation by CHEK1 at Thr-346 and Ser-374 regulates its function in DNA cross-links repair.	NA	Fanconi anemia pathway;Fanconi Anemia Pathway	PE1	6
+NX_Q9HBA0	Transient receptor potential cation channel subfamily V member 4	871	98281	7.83	6	Cell membrane;Adherens junction;Cilium;Endoplasmic reticulum;Apical cell membrane	Neuronopathy, distal hereditary motor, 8;Brachyolmia 3;Parastremmatic dwarfism;Metatropic dysplasia;Spondyloepiphyseal dysplasia Maroteaux type;Charcot-Marie-Tooth disease 2C;Spondylometaphyseal dysplasia Kozlowski type;Avascular necrosis of the femoral head, primary 2;Digital arthropathy-brachydactyly, familial;Scapuloperoneal spinal muscular atrophy	Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli.;Lacks channel activity, due to impaired oligomerization and intracellular retention.;Lacks channel activity, due to impaired oligomerization and intracellular retention.;Lacks channel activity, due to impaired oligomerization and intracellular retention.;Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260).	N-glycosylated.	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily.	TRP channels	PE1	12
+NX_Q9HBA9	Putative N-acetylated-alpha-linked acidic dipeptidase	442	50045	6.53	0	Cytoplasm	NA	Exhibits a dipeptidyl-peptidase IV type activity.;Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity.	NA	Belongs to the peptidase M28 family. M28B subfamily.	Aspartate and asparagine metabolism	PE2	11
+NX_Q9HBB8	Cadherin-related family member 5	845	88223	4.81	1	Apical cell membrane;Microvillus membrane	NA	Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.	N- and O-glycosylated.	NA	NA	PE1	11
+NX_Q9HBD1	Roquin-2	1191	131669	6.43	0	Cytoplasmic vesicle;P-body	NA	Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). MiRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Show the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670) (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670).	Proteolytically cleaved after Arg-509 and Arg-585 by MALT1 in activated CD4(+) T cells; cleavage at Arg-509 and Arg-585 is critical for promoting RC3H1 degradation in response to T-cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling Th17 cell differentiation.	NA	Protein modification; protein ubiquitination.	PE1	9
+NX_Q9HBE1	POZ-, AT hook-, and zinc finger-containing protein 1	687	74060	8.71	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	22
+NX_Q9HBE4	Interleukin-21	162	18653	9.54	0	Secreted	Immunodeficiency, common variable, 11	Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.	NA	Belongs to the IL-15/IL-21 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-21 signaling	PE1	4
+NX_Q9HBE5	Interleukin-21 receptor	538	59130	4.57	1	Membrane;Cytosol;Cell membrane	Immunodeficiency 56	This is a receptor for interleukin-21.	C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.	Belongs to the type I cytokine receptor family. Type 4 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-21 signaling	PE1	16
+NX_Q9HBF4	Zinc finger FYVE domain-containing protein 1	777	87176	7.29	0	Endoplasmic reticulum;Golgi stack	NA	NA	NA	NA	NA	PE1	14
+NX_Q9HBF5	Suppressor of tumorigenicity 20 protein	79	9024	8.52	0	NA	NA	May act as a tumor suppressor. Promotes apoptosis of cancer cells.	NA	NA	NA	PE2	15
+NX_Q9HBG4	V-type proton ATPase 116 kDa subunit a isoform 4	840	96386	5.75	8	Apical cell membrane;Cytosol	Renal tubular acidosis, distal, autosomal recessive	Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney.	NA	Belongs to the V-ATPase 116 kDa subunit family.	Oxidative phosphorylation;Metabolic pathways;Lysosome;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Tuberculosis;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	7
+NX_Q9HBG6	Intraflagellar transport protein 122 homolog	1241	141825	6.08	0	Nucleoplasm;Cytosol;Cilium;Cilium basal body	Cranioectodermal dysplasia 1	As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (PubMed:27932497, PubMed:29220510). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity).	NA	NA	Intraflagellar transport;Hedgehog 'off' state	PE1	3
+NX_Q9HBG7	T-lymphocyte surface antigen Ly-9	655	72139	5.36	1	Membrane;Cell membrane	NA	Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity).	NA	NA	NA	PE1	1
+NX_Q9HBH0	Rho-related GTP-binding protein RhoF	211	23625	8.9	0	Golgi apparatus;Nucleoplasm;Cytoskeleton;Cell membrane	NA	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.	NA	Belongs to the small GTPase superfamily. Rho family.	Rho GTPase cycle;Neutrophil degranulation	PE1	12
+NX_Q9HBH1	Peptide deformylase, mitochondrial	243	27013	9.48	0	Nucleoplasm;Mitochondrion	NA	Removes the formyl group from the N-terminal Met of newly synthesized proteins.	NA	Belongs to the polypeptide deformylase family.	NA	PE1	16
+NX_Q9HBH5	Retinol dehydrogenase 14	336	36865	9.02	0	Endoplasmic reticulum;Nucleoplasm;Cytosol	NA	Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroid.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Cofactor metabolism; retinol metabolism.;RA biosynthesis pathway	PE1	2
+NX_Q9HBH7	Protein BEX1	125	14860	6.31	0	Cytoplasm;Nucleus	NA	Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).	Ubiquitinated. Degraded by the proteasome (By similarity).;Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity).	Belongs to the BEX family.	NA	PE1	X
+NX_Q9HBH9	MAP kinase-interacting serine/threonine-protein kinase 2	465	51875	5.8	0	Cytoplasm;Nucleus;PML body	NA	Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus.;Displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.	Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14. Dephosphorylated by PP2A.;MKNK2 is phosphorylated by MAPK11 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MKNK2 is phosphorylated by MAPK14 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);MKNK2 is phosphorylated by MAPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	MAPK signaling pathway;Insulin signaling pathway	PE1	19
+NX_Q9HBI0	Gamma-parvin	331	37485	5.32	0	Focal adhesion;Cytoskeleton;Cell membrane	NA	Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.	NA	Belongs to the parvin family.	Focal adhesion	PE1	22
+NX_Q9HBI1	Beta-parvin	364	41714	6.26	0	Cell membrane;Focal adhesion;Sarcomere;Lamellipodium;Cytosol;Z line;Cytoskeleton	NA	Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.	NA	Belongs to the parvin family.	Focal adhesion;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components;Cell-extracellular matrix interactions	PE1	22
+NX_Q9HBI5	Uncharacterized protein C3orf14	128	15007	5.67	0	Cytosol;Cell membrane	NA	NA	NA	NA	NA	PE1	3
+NX_Q9HBI6	Cytochrome P450 4F11	524	60146	6.26	1	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:24138531, PubMed:15364545, PubMed:18065749). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15364545, PubMed:18065749, PubMed:24138531). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids (PubMed:18065749, PubMed:19932081). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:24138531). Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed:15364545).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; arachidonate metabolism.;Lipid metabolism; oxylipin biosynthesis.;Cofactor degradation; phylloquinone degradation.;Xenobiotic degradation.;Arachidonic acid metabolism;Metabolic pathways;Miscellaneous substrates;Fatty acids;Eicosanoids;Synthesis of Leukotrienes (LT) and Eoxins (EX)	PE1	19
+NX_Q9HBJ0	Placenta-specific protein 1	212	23616	6.23	0	Secreted;Nucleus;Cell membrane	NA	May play a role in placental development.	NA	Belongs to the PLAC1 family.	NA	PE1	X
+NX_Q9HBJ7	Ubiquitin carboxyl-terminal hydrolase 29	922	104156	5.62	0	NA	NA	NA	NA	Belongs to the peptidase C19 family.	NA	PE2	19
+NX_Q9HBJ8	Collectrin	222	25235	5.43	1	Endoplasmic reticulum;Cytoplasmic vesicle;Cell membrane	NA	Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (PubMed:16330323).	Glycosylated. Glycosylation is required for plasma membrane localization and for its cleavage by BACE2.;Proteolytically processed in pancreatic beta cells by BACE2 leading to the generation and extracellular release of soluble CLTRN, and a corresponding cell-associated C-terminal fragment which is later cleaved by gamma-secretase. This shedding process inactivates CLTRN (By similarity). Three cleavage sites have been identified for BACE2, two clustered sites after Phe-116 and Leu-118 and a more membrane proximal site at Phe-125; the preferred BACE2 cleavage site seems to be between Phe-125 and Leu-126, Phe-116 and Leu-118 act as alternative sites (PubMed:21907142, PubMed:22628310).	Belongs to the CLTRN family.	Insulin processing	PE1	X
+NX_Q9HBK9	Arsenite methyltransferase	375	41748	5.83	0	Cytosol;Mitochondrion	NA	Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed:16407288, PubMed:25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655).	NA	Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.	Methylation	PE1	10
+NX_Q9HBL0	Tensin-1	1735	185701	7.55	0	Cell surface;Focal adhesion;Cytoskeleton	NA	Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.	Rapidly cleaved by calpain II.	NA	NA	PE1	2
+NX_Q9HBL6	Leucine-rich repeat and transmembrane domain-containing protein 1	345	38171	6.26	1	Membrane	NA	NA	NA	NA	NA	PE2	3
+NX_Q9HBL7	Plasminogen receptor (KT)	147	17201	9.58	2	Mitochondrion;Cell membrane	NA	Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9.	NA	NA	NA	PE1	9
+NX_Q9HBL8	NmrA-like family domain-containing protein 1	299	33344	7.06	0	Nucleoplasm;Cytoplasm;Perinuclear region;Nucleus	NA	Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.	NA	Belongs to the NmrA-type oxidoreductase family.	Urea cycle	PE1	16
+NX_Q9HBM0	Vezatin	779	88665	5.11	2	Cell membrane;Stereocilium membrane;Adherens junction;Nucleoplasm;Cytosol;Nucleus;Acrosome	NA	(Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site.;Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process.	NA	Belongs to the vezatin family.	NA	PE1	12
+NX_Q9HBM1	Kinetochore protein Spc25	224	26153	7.7	0	Kinetochore;Cytosol;Nucleus	NA	Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).	NA	Belongs to the SPC25 family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	2
+NX_Q9HBM6	Transcription initiation factor TFIID subunit 9B	251	27622	9.58	0	Nucleus	NA	Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.	NA	Belongs to the TAF9 family.	Basal transcription factors;Herpes simplex infection;RNA Polymerase II Pre-transcription Events;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Regulation of TP53 Activity through Phosphorylation;Ub-specific processing proteases	PE1	X
+NX_Q9HBQ8	Putative golgin subfamily A member 2B	144	15482	5.27	0	NA	NA	NA	NA	Belongs to the GOLGA2 family.	NA	PE5	12
+NX_Q9HBR0	Putative sodium-coupled neutral amino acid transporter 10	1119	119762	5.51	10	Membrane;Golgi apparatus	NA	Putative sodium-dependent amino acid/proton antiporter.	NA	Belongs to the amino acid/polyamine transporter 2 family.	NA	PE1	17
+NX_Q9HBT6	Cadherin-20	801	88993	4.54	1	Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	NA	PE1	18
+NX_Q9HBT7	Zinc finger protein 287	754	87565	8.8	0	Golgi apparatus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	17
+NX_Q9HBT8	Zinc finger protein 286A	521	60175	8.64	0	Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	17
+NX_Q9HBU1	Homeobox protein BarH-like 1	254	27298	9.72	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter.	NA	Belongs to the BAR homeobox family.	NA	PE1	9
+NX_Q9HBU6	Ethanolamine kinase 1	452	50968	6.09	0	Nucleoplasm;Cytoplasm;Cytosol;Cell membrane	NA	Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.	NA	Belongs to the choline/ethanolamine kinase family.	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PE	PE1	12
+NX_Q9HBU9	Popeye domain-containing protein 2	364	40448	5.23	2	Membrane;Sarcolemma	NA	Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density.	NA	Belongs to the popeye family.	NA	PE1	3
+NX_Q9HBV1	Popeye domain-containing protein 3	291	33870	8.12	3	Membrane;Cytosol;Nucleolus	NA	May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding.	NA	Belongs to the popeye family.	NA	PE2	6
+NX_Q9HBV2	Sperm acrosome membrane-associated protein 1	294	32143	4.57	1	Acrosome inner membrane	NA	Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility (PubMed:11870081).	N-glycosylated.	NA	NA	PE1	6
+NX_Q9HBW0	Lysophosphatidic acid receptor 2	351	39084	9.48	7	Cell surface;Cell membrane	NA	Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;G alpha (q) signalling events;Lysosphingolipid and LPA receptors	PE1	19
+NX_Q9HBW1	Leucine-rich repeat-containing protein 4	653	72717	6.58	1	Membrane;Golgi apparatus;Postsynaptic cell membrane	NA	Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity).	N-glycosylated.	NA	NA	PE1	7
+NX_Q9HBW9	Adhesion G protein-coupled receptor L4	690	77811	7.81	7	Cell membrane	NA	Endothelial orphan receptor that acts as a key regulator of angiogenesis.	Glycosylated.;Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	NA	PE1	1
+NX_Q9HBX3	Uncharacterized protein encoded by SND1-IT1	110	12922	8.84	0	NA	NA	NA	NA	NA	NA	PE4	7
+NX_Q9HBX8	Leucine-rich repeat-containing G-protein coupled receptor 6	967	104298	5.43	7	Nucleoplasm;Cell membrane	NA	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.	NA	Belongs to the G-protein coupled receptor 1 family.	Regulation of FZD by ubiquitination	PE1	1
+NX_Q9HBX9	Relaxin receptor 1	757	86975	8.39	7	Cell membrane	NA	Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Relaxin receptors;G alpha (s) signalling events	PE1	4
+NX_Q9HBY0	NADPH oxidase 3	568	64935	8.28	6	Membrane;Cytoplasmic vesicle	NA	NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.	NA	NA	Phagosome;Osteoclast differentiation;Leukocyte transendothelial migration;RHO GTPases Activate NADPH Oxidases	PE1	6
+NX_Q9HBY8	Serine/threonine-protein kinase Sgk2	427	47604	7.16	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.	Activated by phosphorylation on Ser-416 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-253.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Stimuli-sensing channels	PE1	20
+NX_Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	717	78691	6.25	0	Nucleoplasm;Nucleus	Webb-Dattani syndrome	Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE).	NA	NA	Pathways in cancer;Renal cell carcinoma;Xenobiotics;PPARA activates gene expression;Endogenous sterols;Phase I - Functionalization of compounds;Aryl hydrocarbon receptor signalling	PE1	15
+NX_Q9HC07	Transmembrane protein 165	324	34906	6.53	6	Golgi apparatus;Lysosome membrane;trans-Golgi network membrane;Golgi apparatus membrane;Early endosome membrane;Late endosome membrane	Congenital disorder of glycosylation 2K	May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation.	NA	Belongs to the GDT1 family.	NA	PE1	4
+NX_Q9HC10	Otoferlin	1997	226753	5.49	1	Endoplasmic reticulum membrane;Presynaptic cell membrane;Cell membrane;Basolateral cell membrane;Synaptic vesicle membrane;Golgi apparatus membrane	Deafness, autosomal recessive, 9;Auditory neuropathy, autosomal recessive, 1	Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity).	NA	Belongs to the ferlin family.	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	2
+NX_Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	384	46408	8.28	0	Cytoplasm;P-body;Nucleus	NA	DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.	Ubiquitinated in the presence of HIV-1 VIF. Association with VIF targets the protein for proteolysis by the ubiquitin-dependent proteasome pathway.;Phosphorylation at Thr-32 reduces its binding to HIV-1 VIF and subsequent ubiquitination and degradation thus promoting its antiviral activity.	Belongs to the cytidine and deoxycytidylate deaminase family.	Vif-mediated degradation of APOBEC3G;APOBEC3G mediated resistance to HIV-1 infection	PE1	22
+NX_Q9HC21	Mitochondrial thiamine pyrophosphate carrier	320	35511	9.61	6	Mitochondrion inner membrane	Microcephaly, Amish type;Thiamine metabolism dysfunction syndrome 4, bilateral striatal degeneration and progressive polyneuropathy type	Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Vitamin B1 (thiamin) metabolism	PE1	17
+NX_Q9HC23	Prokineticin-2	129	14314	10.12	0	Secreted	Hypogonadotropic hypogonadism 4 with or without anosmia	May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.	NA	Belongs to the AVIT (prokineticin) family.	Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	3
+NX_Q9HC24	Protein lifeguard 4	238	26971	6.58	6	Golgi apparatus membrane	NA	Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.	NA	Belongs to the BI1 family. LFG subfamily.	NA	PE1	12
+NX_Q9HC29	Nucleotide-binding oligomerization domain-containing protein 2	1040	115283	6.3	0	Cytoplasm;Golgi apparatus;Mitochondrion;Basolateral cell membrane;Membrane;Cytosol	Blau syndrome;Inflammatory bowel disease 1;Yao syndrome	Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189).	Polyubiquitinated following MDP stimulation, leading to proteasome-mediated degradation (PubMed:23019338).	NA	NOD-like receptor signaling pathway;Shigellosis;Tuberculosis;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Ovarian tumor domain proteases;Interleukin-1 signaling	PE1	16
+NX_Q9HC35	Echinoderm microtubule-associated protein-like 4	981	108916	5.96	0	Cytosol;Cytoskeleton	NA	May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.	NA	Belongs to the WD repeat EMAP family.	NA	PE1	2
+NX_Q9HC36	rRNA methyltransferase 3, mitochondrial	420	47020	8.89	0	Mitochondrion	NA	S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.	NA	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.	rRNA modification in the mitochondrion	PE1	17
+NX_Q9HC38	Glyoxalase domain-containing protein 4	313	34793	5.4	0	Nucleoplasm;Cytosol;Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the glyoxalase I family.	NA	PE1	17
+NX_Q9HC44	Vasculin-like protein 1	474	52302	6.36	0	Nucleoplasm;Focal adhesion;Nucleus;Cell membrane	NA	Possible transcription factor.	NA	Belongs to the vasculin family.	NA	PE1	1
+NX_Q9HC47	Cutaneous T-cell lymphoma-associated antigen 1	74	8406	5.3	2	Membrane	NA	NA	NA	NA	NA	PE2	18
+NX_Q9HC52	Chromobox protein homolog 8	389	43396	9.92	0	Nucleoplasm;Nucleus	NA	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.	NA	NA	SUMOylation of DNA damage response and repair proteins;Oxidative Stress Induced Senescence;SUMOylation of RNA binding proteins;SUMOylation of chromatin organization proteins;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;SUMOylation of transcription cofactors;SUMOylation of DNA methylation proteins	PE1	17
+NX_Q9HC56	Protocadherin-9	1237	136064	5.26	1	Nucleoplasm;Centrosome;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein.	NA	NA	NA	PE1	13
+NX_Q9HC57	WAP four-disulfide core domain protein 1	220	23977	8.77	0	Secreted	NA	Has growth inhibitory activity.	NA	NA	NA	PE1	16
+NX_Q9HC58	Sodium/potassium/calcium exchanger 3	644	71992	5.19	10	Membrane;Golgi apparatus	NA	Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).	NA	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.	Sodium/Calcium exchangers	PE1	20
+NX_Q9HC62	Sentrin-specific protease 2	589	67855	9.54	0	Cytoplasm;Cytosol;Nucleus membrane;Nuclear pore complex	NA	Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).	Polyubiquitinated; which leads to proteasomal degradation.	Belongs to the peptidase C48 family.	RNA transport;Wnt signaling pathway;SUMO is proteolytically processed	PE1	3
+NX_Q9HC73	Cytokine receptor-like factor 2	371	42013	5.11	1	Secreted;Cell membrane	NA	Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.	NA	Belongs to the type I cytokine receptor family. Type 5 subfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-7 signaling	PE1	X
+NX_Q9HC77	Centromere protein J	1338	153000	6.23	0	Nucleoplasm;Centrosome;Cell membrane;Centriole	Seckel syndrome 4;Microcephaly 6, primary, autosomal recessive	Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797).	Phosphorylation at Ser-589 and Ser-595 by PLK2 is required for procentriole formation and centriole elongation. Phosphorylation by PLK2 oscillates during the cell cycle: it increases at G1/S transition and decreases during the exit from mitosis. Phosphorylation at Ser-595 is also mediated by PLK4 but is not a critical step in PLK4 function in procentriole assembly.	Belongs to the TCP10 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	13
+NX_Q9HC78	Zinc finger and BTB domain-containing protein 20	741	81083	6.03	0	Nucleoplasm;Nucleus	Primrose syndrome	May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).	Sumoylated with SUMO1.	NA	NA	PE1	3
+NX_Q9HC84	Mucin-5B	5762	596340	6.2	0	Cytoplasmic vesicle;Secreted	Pulmonary fibrosis, idiopathic	Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.	Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc(2)Hex(1)HexNac1-ol.	NA	Salivary secretion;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	11
+NX_Q9HC96	Calpain-10	672	74952	7.97	0	Nucleoplasm;Cytosol	Diabetes mellitus, non-insulin-dependent, 1	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.	NA	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	2
+NX_Q9HC97	G-protein coupled receptor 35	309	34072	9.06	7	Cell membrane	NA	Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Class A/1 (Rhodopsin-like receptors)	PE1	2
+NX_Q9HC98	Serine/threonine-protein kinase Nek6	313	35714	8.26	0	Cytoplasm;Nucleus speckle;Centriolar satellite;Nucleoplasm;Spindle pole;Centrosome;Cytosol;Nucleus	NA	Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361).	Autophosphorylated. Phosphorylation at Ser-206 is required for its activation. Phosphorylated upon IR or UV-induced DNA damage. Phosphorylated by CHEK1 and CHEK2. Interaction with APBB1 down-regulates phosphorylation at Thr-210.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);NEK6 is phosphorylated by CHEK2	Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	Nuclear Pore Complex (NPC) Disassembly;Activation of NIMA Kinases NEK9, NEK6, NEK7	PE1	9
+NX_Q9HCB6	Spondin-1	807	90973	5.85	0	Nucleoplasm;Extracellular matrix;Nucleolus;Cytoskeleton	NA	Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.	NA	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	11
+NX_Q9HCC0	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	563	61333	7.58	0	Mitochondrion matrix;Mitochondrion	3-methylcrotonoyl-CoA carboxylase 2 deficiency	Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.	NA	Belongs to the AccD/PCCB family.	Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.;Valine, leucine and isoleucine degradation;Metabolic pathways;Branched-chain amino acid catabolism;Biotin transport and metabolism;Defective HLCS causes multiple carboxylase deficiency	PE1	5
+NX_Q9HCC6	Transcription factor HES-4	221	23523	11.11	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus;Cytosol	NA	Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity).	NA	NA	NA	PE1	1
+NX_Q9HCC8	Glycerophosphoinositol inositolphosphodiesterase GDPD2	539	61729	8.77	6	Cytoplasm;Cell membrane;Cytoskeleton	NA	Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity).	NA	Belongs to the glycerophosphoryl diester phosphodiesterase family.	NA	PE1	X
+NX_Q9HCC9	Lateral signaling target protein 2 homolog	887	96490	4.99	0	Early endosome membrane;Nucleoplasm;Cytosol;Cell membrane	NA	Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.	Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes.	Belongs to the lst-2 family.	NA	PE1	4
+NX_Q9HCD5	Nuclear receptor coactivator 5	579	65536	9.62	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).	NA	NA	NA	PE1	20
+NX_Q9HCD6	Protein TANC2	1990	219650	8.31	0	Cytosol	NA	NA	NA	Belongs to the TANC family.	NA	PE1	17
+NX_Q9HCE0	Ectopic P granules protein 5 homolog	2579	292481	5.99	0	Lysosome;Nucleus speckle;Perinuclear region	Vici syndrome	Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located (PubMed:29130391).	NA	Belongs to the EPG5 family.	NA	PE1	18
+NX_Q9HCE1	Helicase MOV-10	1003	113671	9	0	Cytoplasm;Stress granule;Cytoplasmic ribonucleoprotein granule;P-body;Cytosol;Nucleus	NA	(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.;5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568).	NA	Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.	MAPK6/MAPK4 signaling;Oxidative Stress Induced Senescence;Pre-NOTCH Transcription and Translation;TP53 Regulates Metabolic Genes;Ca2+ pathway;Oncogene Induced Senescence;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of RUNX1 Expression and Activity;Regulation of PTEN mRNA translation;Competing endogenous RNAs (ceRNAs) regulate PTEN translation;Estrogen-dependent gene expression;Transcriptional Regulation by MECP2;Regulation of MECP2 expression and activity	PE1	1
+NX_Q9HCE3	Zinc finger protein 532	1301	141696	8.92	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	18
+NX_Q9HCE5	N6-adenosine-methyltransferase non-catalytic subunit	456	52150	5.89	0	Nucleoplasm;Nucleus	NA	The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:29348140, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity).	NA	Belongs to the MT-A70-like family.	Processing of Capped Intron-Containing Pre-mRNA	PE1	4
+NX_Q9HCE6	Rho guanine nucleotide exchange factor 10-like protein	1279	140379	5.62	0	Golgi apparatus;Cytosol;Cytoplasm;Cytoplasmic vesicle	NA	Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	1
+NX_Q9HCE7	E3 ubiquitin-protein ligase SMURF1	757	86114	6.56	0	Nucleoplasm;Cytoplasm;Cell membrane;Cytoplasmic vesicle	NA	E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003).	Auto-ubiquitinated in presence of NDFIP1 (PubMed:23087404). Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site.	NA	Protein modification; protein ubiquitination.;Asymmetric localization of PCP proteins;Hedgehog 'on' state;Antigen processing: Ubiquitination &amp; Proteasome degradation;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Signaling by BMP;Downregulation of TGF-beta receptor signaling;Regulation of RUNX3 expression and activity;Regulation of RUNX2 expression and activity	PE1	7
+NX_Q9HCE9	Anoctamin-8	1232	136034	5.62	8	Nucleoplasm;Nucleolus;Cell membrane	NA	Does not exhibit calcium-activated chloride channel (CaCC) activity.	NA	Belongs to the anoctamin family.	Stimuli-sensing channels;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	19
+NX_Q9HCF6	Transient receptor potential cation channel subfamily M member 3	1732	197571	6.74	7	Membrane;Cytoplasmic vesicle	NA	Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.	NA	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM3 sub-subfamily.	TRP channels	PE1	9
+NX_Q9HCG1	Zinc finger protein 160	818	94112	9.44	0	Cytosol;Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9HCG7	Non-lysosomal glucosylceramidase	927	104649	5.61	0	Golgi apparatus;Endoplasmic reticulum membrane;Nucleoplasm;Golgi apparatus membrane;Cytosol	Spastic paraplegia 46, autosomal recessive	Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide (PubMed:17105727, PubMed:30308956). Glucosylceramides are membrane glycosphingolipids that have a wide intracellular distribution (By similarity). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (By similarity). Also involved in the transglucosylation of cholesterol, transferring glucose from glucosylceramides, thereby modifying its water solubility and biological properties (By similarity). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (By similarity). Finally, may also play a role in the metabolism of bile acids (PubMed:11489889, PubMed:9111029, PubMed:17080196). It is able to hydrolyze bile acid 3-O-glucosides but also to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PubMed:11489889, PubMed:9111029, PubMed:17080196). However, the relevance of both activities is unclear in vivo (By similarity).	NA	Belongs to the non-lysosomal glucosylceramidase family.	Lipid metabolism; sphingolipid metabolism.;Steroid metabolism; cholesterol metabolism.;Glycosphingolipid metabolism	PE1	9
+NX_Q9HCG8	Pre-mRNA-splicing factor CWC22 homolog	908	105466	6.6	0	Cytosol;Nucleus speckle;Nucleus	NA	Required for pre-mRNA splicing as component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.	NA	Belongs to the CWC22 family.	mRNA Splicing - Major Pathway	PE1	2
+NX_Q9HCH0	Nck-associated protein 5-like	1330	139013	8.45	0	Golgi apparatus;Centrosome	NA	Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573).	CDK1/Cyclin B-dependent phosphorylation mediates its dissociation from centrosomes during mitosis.	NA	NA	PE1	12
+NX_Q9HCH3	Copine-5	593	65734	5.65	0	Cytosol;Perikaryon;Cell projection	NA	Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).	NA	Belongs to the copine family.	NA	PE1	6
+NX_Q9HCH5	Synaptotagmin-like protein 2	934	104930	7.96	0	Golgi apparatus;Nucleoplasm;Cytoplasm;Cell membrane	NA	Acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse.;Binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.	Is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A.	NA	NA	PE1	11
+NX_Q9HCI5	Melanoma-associated antigen E1	957	103254	5.24	0	Cell membrane;Cytosol;Perinuclear region;Nucleus;Cytoskeleton	NA	May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.	NA	NA	NA	PE1	X
+NX_Q9HCI6	E3 SUMO-protein ligase KIAA1586	787	89673	7.78	0	Nucleoplasm;Nucleus membrane	NA	E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493).	NA	NA	Protein modification; protein sumoylation.	PE1	6
+NX_Q9HCI7	E3 ubiquitin-protein ligase MSL2	577	62541	8.11	0	Nucleoplasm;Midbody	NA	Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.	NA	Belongs to the MSL2 family.	HATs acetylate histones	PE1	3
+NX_Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	1690	175964	6.47	0	Nucleoplasm	NA	Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.	NA	Belongs to the GW182 family.	MAPK6/MAPK4 signaling;Oxidative Stress Induced Senescence;Pre-NOTCH Transcription and Translation;TP53 Regulates Metabolic Genes;Ca2+ pathway;Post-transcriptional silencing by small RNAs;Oncogene Induced Senescence;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of RUNX1 Expression and Activity;Regulation of PTEN mRNA translation;Competing endogenous RNAs (ceRNAs) regulate PTEN translation;Estrogen-dependent gene expression;Transcriptional Regulation by MECP2;Regulation of MECP2 expression and activity	PE1	17
+NX_Q9HCJ1	Progressive ankylosis protein homolog	492	54241	8	8	Membrane;Cytosol	Craniometaphyseal dysplasia, autosomal dominant;Chondrocalcinosis 2	Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.	NA	Belongs to the ANKH family.	Miscellaneous transport and binding events	PE1	5
+NX_Q9HCJ2	Leucine-rich repeat-containing protein 4C	640	71950	6.7	1	Cytosol;Postsynaptic cell membrane	NA	May promote neurite outgrowth of developing thalamic neurons.	NA	NA	Axon guidance	PE1	11
+NX_Q9HCJ3	Ribonucleoprotein PTB-binding 2	691	74339	7.12	0	Nucleoplasm;Cytoplasm;Nucleus	NA	May bind single-stranded nucleic acids.	NA	NA	NA	PE1	1
+NX_Q9HCJ5	Zinc finger SWIM domain-containing protein 6	1215	133470	7.01	0	Cytosol	Neurodevelopmental disorder with movement abnormalities, abnormal gait, and autistic features;Acromelic frontonasal dysostosis	Involved in nervous system development, important for striatal morphology and motor regulation.	NA	NA	NA	PE1	5
+NX_Q9HCJ6	Synaptic vesicle membrane protein VAT-1 homolog-like	419	45899	4.98	0	Cytosol	NA	NA	NA	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.	NA	PE1	16
+NX_Q9HCK0	Zinc finger and BTB domain-containing protein 26	441	49953	6.62	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	9
+NX_Q9HCK1	DBF4-type zinc finger-containing protein 2	2354	265618	5.79	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	2
+NX_Q9HCK4	Roundabout homolog 2	1378	151200	5.95	1	Membrane;Nucleoplasm;Centriolar satellite	Vesicoureteral reflux 2	Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.	NA	Belongs to the immunoglobulin superfamily. ROBO family.	Axon guidance;Signaling by ROBO receptors;Regulation of commissural axon pathfinding by SLIT and ROBO;Regulation of expression of SLITs and ROBOs;ROBO receptors bind AKAP5;Regulation of cortical dendrite branching	PE1	3
+NX_Q9HCK5	Protein argonaute-4	861	97097	9.21	0	P-body	NA	Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).	NA	Belongs to the argonaute family. Ago subfamily.	MAPK6/MAPK4 signaling;Oxidative Stress Induced Senescence;MicroRNA (miRNA) biogenesis;Pre-NOTCH Transcription and Translation;Small interfering RNA (siRNA) biogenesis;TP53 Regulates Metabolic Genes;Ca2+ pathway;Post-transcriptional silencing by small RNAs;Oncogene Induced Senescence;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of RUNX1 Expression and Activity;Regulation of PTEN mRNA translation;Competing endogenous RNAs (ceRNAs) regulate PTEN translation;Estrogen-dependent gene expression;Transcriptional Regulation by MECP2;Regulation of MECP2 expression and activity	PE1	1
+NX_Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	2581	290519	6.04	0	Nucleoplasm;Nucleus;Cell membrane	Autism 18	DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.	Sumoylated.	Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.	Wnt signaling pathway;Deactivation of the beta-catenin transactivating complex	PE1	14
+NX_Q9HCL0	Protocadherin-18	1135	126149	4.99	1	Golgi apparatus;Cytosol;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein.	NA	NA	NA	PE1	4
+NX_Q9HCL2	Glycerol-3-phosphate acyltransferase 1, mitochondrial	828	93795	7.81	2	Mitochondrion outer membrane;Mitochondrion	NA	Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.	NA	Belongs to the GPAT/DAPAT family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.;Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PA;Triglyceride biosynthesis;Activation of gene expression by SREBF (SREBP);RUNX1 regulates estrogen receptor mediated transcription;Estrogen-dependent gene expression	PE1	10
+NX_Q9HCL3	Zinc finger protein 14 homolog	533	63463	8.92	0	Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9HCM1	Retroelement silencing factor 1	1747	194857	8.95	0	Nucleus;Cytosol;Nucleolus;Cytoskeleton	NA	Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells.	NA	NA	NA	PE1	12
+NX_Q9HCM2	Plexin-A4	1894	212455	6.42	1	Cell membrane	NA	Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).	NA	Belongs to the plexin family.	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Sema3A PAK dependent Axon repulsion;CRMPs in Sema3A signaling;Other semaphorin interactions;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	7
+NX_Q9HCM3	UPF0606 protein KIAA1549	1950	210755	5.75	2	Membrane;Nucleus membrane;Cytoskeleton	NA	NA	O-glycosylated. O-mannosylated by POMT1 and POMT2 and elongated by POMGNT1.	Belongs to the UPF0606 family.	Signaling by BRAF and RAF fusions	PE1	7
+NX_Q9HCM4	Band 4.1-like protein 5	733	81856	6.15	0	Cytoplasm;Adherens junction;Cell membrane	NA	May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells.	NA	NA	Neurexins and neuroligins	PE1	2
+NX_Q9HCM7	Fibrosin-1-like protein	1045	110907	9.7	0	Nucleoplasm;Cytosol;Cell membrane	NA	NA	NA	Belongs to the AUTS2 family.	NA	PE1	12
+NX_Q9HCM9	E3 ubiquitin-protein ligase TRIM39	518	59690	7.8	0	Cytosol;Mitochondrion	NA	E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.	Autoubiquitinated.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	6
+NX_Q9HCN2	p53-regulated apoptosis-inducing protein 1	124	12935	10.26	0	Mitochondrion	NA	May play an important role in mediating p53/TP53-dependent apoptosis.	NA	NA	p53 signaling pathway;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	PE2	11
+NX_Q9HCN3	Post-GPI attachment to proteins factor 6	771	84761	7.67	7	Nucleoplasm;Lysosome membrane;Cytoskeleton;Cell membrane	NA	Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401).	Glycosylated.	Belongs to the TMEM8 family.	NA	PE1	16
+NX_Q9HCN4	GPN-loop GTPase 1	374	41740	4.8	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	NA	Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).	NA	Belongs to the GPN-loop GTPase family.	NA	PE1	2
+NX_Q9HCN6	Platelet glycoprotein VI	339	36866	9.35	1	Nucleoplasm;Cell membrane	Bleeding disorder, platelet-type 11	Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.	N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).	NA	ECM-receptor interaction;GPVI-mediated activation cascade;Cell surface interactions at the vascular wall;Platelet Adhesion to exposed collagen	PE1	19
+NX_Q9HCN8	Stromal cell-derived factor 2-like protein 1	221	23598	6.52	0	Endoplasmic reticulum lumen	NA	NA	NA	NA	NA	PE1	22
+NX_Q9HCP0	Casein kinase I isoform gamma-1	422	48511	9.13	0	Cytoplasm;Cytosol	NA	Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.	Autophosphorylated.	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.	Hedgehog signaling pathway	PE1	15
+NX_Q9HCP6	Protein-cysteine N-palmitoyltransferase HHAT-like protein	504	56703	6.67	8	Endoplasmic reticulum membrane	NA	Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN.	NA	Belongs to the membrane-bound acyltransferase family. HHAT subfamily.	NA	PE1	3
+NX_Q9HCQ5	Polypeptide N-acetylgalactosaminyltransferase 9	603	68359	8.73	1	Cytoplasmic vesicle;Golgi apparatus membrane	NA	Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	12
+NX_Q9HCQ7	Pro-FMRFamide-related neuropeptide VF	196	22309	9.26	0	Secreted	NA	Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine-induced analgesia.	NA	Belongs to the FARP (FMRFamide related peptide) family.	NA	PE1	7
+NX_Q9HCR9	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	933	104752	6.15	0	Cytosol	Primary pigmented nodular adrenocortical disease 2	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.	NA	Belongs to the cyclic nucleotide phosphodiesterase family.	Purine metabolism;G alpha (s) signalling events;cGMP effects	PE1	2
+NX_Q9HCS2	Cytochrome P450 4F12	524	60309	7.29	2	Microsome membrane;Endoplasmic reticulum membrane	NA	A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-2 position. Metabolizes (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) toward 18-hydroxy arachidonate (PubMed:11162607). Catalyzes the epoxidation of double bonds of PUFAs such as docosapentaenoic and docosahexaenoic acids (PubMed:16112640). Has low omega-hydroxylase activity toward leukotriene B4 and arachidonate (PubMed:11162645). Involved in the metabolism of xenobiotics. Catalyzes the hydroxylation of the antihistamine drug ebastine (PubMed:11162645).	NA	Belongs to the cytochrome P450 family.	Lipid metabolism; arachidonate metabolism.;Fatty acids;Eicosanoids	PE1	19
+NX_Q9HCS4	Transcription factor 7-like 1	588	62631	9	0	Nucleoplasm;Cytosol;Nucleus	NA	Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.	NA	Belongs to the TCF/LEF family.	Wnt signaling pathway;Adherens junction;Melanogenesis;Pathways in cancer;Colorectal cancer;Endometrial cancer;Prostate cancer;Thyroid cancer;Basal cell carcinoma;Acute myeloid leukemia;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Formation of the beta-catenin:TCF transactivating complex;Ca2+ pathway;Deactivation of the beta-catenin transactivating complex;Binding of TCF/LEF:CTNNB1 to target gene promoters;Repression of WNT target genes;RUNX3 regulates WNT signaling	PE1	2
+NX_Q9HCS5	Band 4.1-like protein 4A	686	79059	9.44	0	Nucleoplasm;Cytoskeleton;Cell membrane	NA	NA	NA	NA	NA	PE1	5
+NX_Q9HCS7	Pre-mRNA-splicing factor SYF1	855	100010	5.87	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804).	NA	Belongs to the crooked-neck family.	Spliceosome;mRNA Splicing - Major Pathway;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER	PE1	19
+NX_Q9HCT0	Fibroblast growth factor 22	170	19663	11.81	0	Secreted	NA	Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;FGFR2b ligand binding and activation;PI3K Cascade;PIP3 activates AKT signaling;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Signaling by FGFR2 in disease;FGFR1b ligand binding and activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;FGFRL1 modulation of FGFR1 signaling	PE1	19
+NX_Q9HCU0	Endosialin	757	80859	5.18	1	Membrane;Nucleoplasm;Cell membrane	NA	May play a role in tumor angiogenesis.	O-glycosylated with sialylated oligosaccharides.;May be N-glycosylated.	NA	NA	PE1	11
+NX_Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	2923	317453	5.14	7	Cytosol;Cell membrane	NA	Receptor that may have an important role in cell/cell signaling during nervous system formation.	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.	NA	PE1	1
+NX_Q9HCU5	Prolactin regulatory element-binding protein	417	45468	8.02	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Nucleus	NA	Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.;Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.	NA	NA	Protein processing in endoplasmic reticulum;XBP1(S) activates chaperone genes;COPII-mediated vesicle transport;Cargo concentration in the ER	PE1	2
+NX_Q9HCU8	DNA polymerase delta subunit 4	107	12433	6.29	0	Centriolar satellite;Nucleus	NA	As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity (PubMed:16510448, PubMed:19074196, PubMed:20334433). Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system (PubMed:24035200). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb (PubMed:24310611). Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196). Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival (PubMed:24022480).	Ubiquitinated; undergoes 'Lys-48'-linked ubiquitination in response to UV irradiation, leading to proteasomal degradation (PubMed:17317665, PubMed:16934752, PubMed:23233665, PubMed:23913683). This modification is partly mediated by RNF8 and by the DCX(DTL) E3 ubiquitin ligase complex (also called CRL4(CDT2)) (PubMed:23233665, PubMed:24022480). Efficient degradation requires the presence of PCNA and is required for the inhibition of fork progression after DNA damage (PubMed:24022480).	Belongs to the DNA polymerase delta subunit 4 family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination;HTLV-I infection;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Termination of translesion DNA synthesis;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Polymerase switching on the C-strand of the telomere;Processive synthesis on the C-strand of the telomere;Telomere C-strand (Lagging Strand) Synthesis;Removal of the Flap Intermediate from the C-strand;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER	PE1	11
+NX_Q9HCU9	Breast cancer metastasis-suppressor 1	246	28461	4.69	0	Endoplasmic reticulum;Cytoplasm;Centrosome;Nucleus	NA	Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.	Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.	Belongs to the BRMS1 family.	HDACs deacetylate histones	PE1	11
+NX_Q9HCX3	Zinc finger protein 304	659	75047	8.73	0	Nucleus speckle;Nucleus	NA	Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979).	Deubiquitinated by USP28; the deubiquitination leads to the stabilization of ZNF304 from proteolytic degradation (PubMed:24623306).	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9HCX4	Short transient receptor potential channel 7	862	99562	8.02	6	Nucleus envelope;Focal adhesion;Cytoskeleton;Cell membrane	NA	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.	Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily.	TRP channels;Effects of PIP2 hydrolysis;Role of second messengers in netrin-1 signaling;Elevation of cytosolic Ca2+ levels	PE1	5
+NX_Q9HCY8	Protein S100-A14	104	11662	5.16	0	Cytoplasm;Cell membrane;Cell junction;Cytosol;Nucleus	NA	Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.	NA	Belongs to the S-100 family.	NA	PE1	1
+NX_Q9HCZ1	Zinc finger protein 334	680	79649	9.33	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	20
+NX_Q9HD15	Steroid receptor RNA activator 1	236	25673	6.54	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.	NA	Belongs to the SRA1 family.	NA	PE1	5
+NX_Q9HD20	Manganese-transporting ATPase 13A1	1204	132955	8.46	10	Cytoplasmic vesicle;Endoplasmic reticulum membrane	NA	Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.	Ion transport by P-type ATPases	PE1	19
+NX_Q9HD23	Magnesium transporter MRS2 homolog, mitochondrial	443	50318	6.44	2	Mitochondrion inner membrane	NA	Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).	NA	Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.	Miscellaneous transport and binding events	PE1	6
+NX_Q9HD26	Golgi-associated PDZ and coiled-coil motif-containing protein	462	50520	5.59	0	Golgi apparatus;Cytoplasm;trans-Golgi network membrane;Postsynaptic density;Synapse;Golgi apparatus membrane;Dendrite	NA	Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.	NA	NA	RHO GTPases regulate CFTR trafficking	PE1	6
+NX_Q9HD33	39S ribosomal protein L47, mitochondrial	250	29450	10.38	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL29 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	3
+NX_Q9HD34	LYR motif-containing protein 4	91	10758	10.73	0	Mitochondrion;Nucleus	Combined oxidative phosphorylation deficiency 19	Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.	NA	Belongs to the complex I LYR family.	Cofactor biosynthesis; iron-sulfur cluster biosynthesis.;Mitochondrial iron-sulfur cluster biogenesis	PE1	6
+NX_Q9HD36	Bcl-2-like protein 10	204	23204	9.63	1	Mitochondrion;Nucleus membrane	NA	Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.	NA	Belongs to the Bcl-2 family.	NA	PE1	15
+NX_Q9HD40	O-phosphoseryl-tRNA(Sec) selenium transferase	501	55726	8.31	0	Cytoplasmic vesicle;Cytoplasm	Pontocerebellar hypoplasia 2D	Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.	NA	Belongs to the SepSecS family.	Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.;Selenocompound metabolism;Aminoacyl-tRNA biosynthesis;Selenocysteine synthesis	PE1	4
+NX_Q9HD42	Charged multivesicular body protein 1a	196	21703	7.77	0	Cytoplasm;Nucleus matrix;Endosome membrane	Pontocerebellar hypoplasia 8	Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.	NA	Belongs to the SNF7 family.	NA	PE1	16
+NX_Q9HD43	Receptor-type tyrosine-protein phosphatase H	1115	122353	5.16	1	Cytoplasm;Apical cell membrane;Mitochondrion;Microvillus membrane	NA	Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity).	NA	Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.	NA	PE1	19
+NX_Q9HD45	Transmembrane 9 superfamily member 3	589	67888	6.83	9	Membrane;Golgi apparatus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	NA	PE1	10
+NX_Q9HD47	Ran guanine nucleotide release factor	186	20448	4.8	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Perinuclear region;Nucleus	NA	May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375).	NA	Belongs to the MOG1 family.	Phase 0 - rapid depolarisation	PE1	17
+NX_Q9HD64	X antigen family member 1	81	9078	9.65	0	Nucleoplasm	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q9HD67	Unconventional myosin-X	2058	237347	5.85	0	Filopodium tip;Cell cortex;Filopodium membrane;Cell membrane;Nucleolus;Lamellipodium;Ruffle;Cytosol;Cytoskeleton	NA	Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity).;Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.	The initiator methionine for isoform Headless is removed.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Fc gamma R-mediated phagocytosis;Regulation of actin dynamics for phagocytic cup formation;Netrin-1 signaling	PE1	5
+NX_Q9HD87	Putative uncharacterized protein C6orf50	102	12368	8.35	1	Membrane	NA	NA	NA	NA	NA	PE5	6
+NX_Q9HD89	Resistin	108	11419	6.52	0	Secreted	NA	Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728).	NA	Belongs to the resistin/FIZZ family.	Neutrophil degranulation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	19
+NX_Q9HD90	Neurogenic differentiation factor 4	331	37041	6.37	0	Nucleus	NA	Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).	Serine or threonine phosphorylation within the basic region may regulate neurogenic activity.	NA	NA	PE1	12
+NX_Q9HDB5	Neurexin-3-beta	637	69305	6.75	1	Membrane	NA	Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity).	Proccessed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides.	Belongs to the neurexin family.	Cell adhesion molecules (CAMs);Neurexins and neuroligins	PE1	14
+NX_Q9HDB8	Endogenous retrovirus group K member 5 Env polyprotein	245	27904	5.6	0	Virion	NA	Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.	NA	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.	NA	PE2	3
+NX_Q9HDB9	Endogenous retrovirus group K member 5 Gag polyprotein	667	73588	9.26	0	Cell membrane	NA	The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.	Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).;Specific enzymatic cleavages may yield mature proteins.	Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.	NA	PE1	3
+NX_Q9HDC5	Junctophilin-1	661	71686	9.37	1	Nucleoplasm;Endoplasmic reticulum membrane;Sarcoplasmic reticulum membrane;Cell membrane	NA	Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.	NA	Belongs to the junctophilin family.	NA	PE1	8
+NX_Q9HDC9	Adipocyte plasma membrane-associated protein	416	46480	5.82	1	Membrane;Cell membrane	NA	Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.	NA	Belongs to the strictosidine synthase family.	NA	PE1	20
+NX_Q9HDD0	Phospholipase A and acyltransferase 1	168	18750	5.37	1	Cytoplasm;Focal adhesion;Membrane;Cytosol;Nucleus	NA	Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:21880860, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:21880860, PubMed:22825852, PubMed:27623847). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:21880860). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (PubMed:21880860, PubMed:22825852, PubMed:27623847).	NA	Belongs to the H-rev107 family.	Acyl chain remodelling of PE	PE1	3
+NX_Q9N2J8	HERV-H_2q24.1 provirus ancestral Env polyprotein	555	60911	8.88	1	Virion;Cell membrane	NA	TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.;SU mediates receptor recognition.	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the gamma type-C retroviral envelope protein family. HERV class-I H env subfamily.	NA	PE2	2
+NX_Q9N2K0	HERV-H_2q24.3 provirus ancestral Env polyprotein	584	64318	8.61	1	Virion;Cell membrane	NA	TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).;SU mediates receptor recognition.;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties but has immunosuppressive properties in vivo.	The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity).;Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the gamma type-C retroviral envelope protein family. HERV class-I H env subfamily.	NA	PE2	2
+NX_Q9NNW5	WD repeat-containing protein 6	1121	121725	6.41	0	Cytoplasm;Cytosol;Cell membrane	NA	Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.	NA	Belongs to the WD repeat WDR6 family.	NA	PE1	3
+NX_Q9NNW7	Thioredoxin reductase 2, mitochondrial	524	56507	7.24	0	Cytoplasm;Cytosol;Mitochondrion;Nucleus	Glucocorticoid deficiency 5	Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.	NA	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Pyrimidine metabolism;Selenocompound metabolism;Detoxification of Reactive Oxygen Species	PE1	22
+NX_Q9NNX1	Tuftelin	390	44264	5.68	0	Cytoplasm;Secreted;Cytoplasmic vesicle	NA	Involved in the mineralization and structural organization of enamel.	NA	Belongs to the tuftelin family.	NA	PE1	1
+NX_Q9NNX6	CD209 antigen	404	45775	5.43	1	Secreted;Cell membrane	NA	(Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2.;(Microbial infection) Acts as an attachment receptor for Influenzavirus A.;On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.;(Microbial infection) Acts as an attachment receptor for Cytomegalovirus.;(Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1.;(Microbial infection) Acts as an attachment receptor for Ebolavirus.;Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.;(Microbial infection) Acts as an attachment receptor for Measles virus.;(Microbial infection) Acts as an attachment receptor for HCV.;(Microbial infection) Acts as an attachment receptor for SARS coronavirus.;(Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus.;(Microbial infection) Acts as an attachment receptor for Lassa virus (PubMed:23966408). Acts as an attachment receptor for Marburg virusn.;(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.;(Microbial infection) Acts as an attachment receptor for West-nile virus.;(Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus.;(Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498). Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928).;(Microbial infection) Acts as an attachment receptor for Dengue virus.	NA	NA	Phagosome;Tuberculosis;Measles;CD209 (DC-SIGN) signaling;Butyrophilin (BTN) family interactions	PE1	19
+NX_Q9NNX9	Variable charge X-linked protein 3	186	20020	4.51	0	NA	NA	May mediate a process in spermatogenesis or may play a role in sex ratio distortion.	NA	Belongs to the VCX/VCY family.	NA	PE2	X
+NX_Q9NNZ3	DnaJ homolog subfamily C member 4	241	27593	10.56	1	Membrane	NA	NA	NA	NA	NA	PE1	11
+NX_Q9NNZ6	Protamine-3	103	11232	4.56	0	Nucleus;Chromosome	NA	Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).	NA	Belongs to the protamine P3 family.	NA	PE1	16
+NX_Q9NP08	Homeobox protein HMX1	348	36155	6.28	0	Nucleus	Oculoauricular syndrome	DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear.	NA	Belongs to the HMX homeobox family.	NA	PE1	4
+NX_Q9NP31	SH2 domain-containing protein 2A	389	42934	6.96	0	Cytoplasm	NA	Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.	Phosphorylated on tyrosine residues.	NA	VEGF signaling pathway;VEGFA-VEGFR2 Pathway	PE1	1
+NX_Q9NP50	SIN3-HDAC complex-associated factor	221	24852	9.51	0	Nucleoplasm;Cytosol;Nucleus	NA	Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity).	NA	Belongs to the SINHCAF family.	NA	PE1	12
+NX_Q9NP55	BPI fold-containing family A member 1	256	26713	5.42	0	Secreted	NA	Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608). Plays a role in the innate immune responses of the upper airways (PubMed:23499554, PubMed:23132494). Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554, PubMed:23132494, PubMed:27145151). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24124190, PubMed:24043776). Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234). May attract macrophages and neutrophils (PubMed:23132494).	May be N-glycosylated.	Belongs to the BPI/LBP/Plunc superfamily. Plunc family.	Antimicrobial peptides	PE1	20
+NX_Q9NP56	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	450	51835	6.54	0	Nucleoplasm	NA	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.	NA	Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.;Purine metabolism;G alpha (s) signalling events	PE1	6
+NX_Q9NP58	ATP-binding cassette sub-family B member 6, mitochondrial	842	93886	8.75	10	Mitochondrion outer membrane;Golgi apparatus;Mitochondrion;Endoplasmic reticulum membrane;Cell membrane;Endosome membrane;Nucleoplasm;Golgi apparatus membrane;Cytosol	Microphthalmia, isolated, with coloboma, 7;Dyschromatosis universalis hereditaria 3;Pseudohyperkalemia, familial, 2, due to red cell leak	Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.	NA	Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.	ABC transporters;Mitochondrial ABC transporters;Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)	PE1	2
+NX_Q9NP59	Solute carrier family 40 member 1	571	62542	6.08	10	Nucleoplasm;Cytosol;Cell membrane	Hemochromatosis 4	May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).	NA	Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	Mineral absorption;Iron uptake and transport;Metal ion SLC transporters;Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages);Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum);Defective CP causes aceruloplasminemia (ACERULOP)	PE1	2
+NX_Q9NP60	X-linked interleukin-1 receptor accessory protein-like 2	686	78670	6.05	1	Membrane	NA	NA	NA	Belongs to the interleukin-1 receptor family.	Receptor-type tyrosine-protein phosphatases	PE2	X
+NX_Q9NP61	ADP-ribosylation factor GTPase-activating protein 3	516	56928	7.04	0	Golgi apparatus;Cytoplasm;Cytosol;Golgi apparatus membrane	NA	GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.	NA	NA	Endocytosis;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	22
+NX_Q9NP62	Chorion-specific transcription factor GCMa	436	49268	6.57	0	Cytoplasmic vesicle;Nucleus	NA	Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068).	Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).	NA	NA	PE1	6
+NX_Q9NP64	Nucleolar protein of 40 kDa	241	27570	9.72	0	Nucleolus	NA	NA	NA	NA	NA	PE1	1
+NX_Q9NP66	High mobility group protein 20A	347	40144	6.08	0	Nucleoplasm;Nucleus	NA	Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).	NA	NA	NA	PE1	15
+NX_Q9NP70	Ameloblastin	447	48283	4.79	0	Cytoplasmic vesicle;Nucleoplasm;Extracellular matrix	Amelogenesis imperfecta 1F	Involved in the mineralization and structural organization of enamel.	NA	Belongs to the ameloblastin family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	4
+NX_Q9NP71	Carbohydrate-responsive element-binding protein	852	93073	8.7	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).	Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding activity.	NA	ChREBP activates metabolic gene expression;AMPK inhibits chREBP transcriptional activation activity;PP2A-mediated dephosphorylation of key metabolic factors;PKA-mediated phosphorylation of key metabolic factors	PE1	7
+NX_Q9NP72	Ras-related protein Rab-18	206	22977	5.11	0	Cytoplasm;Nucleus;Cell membrane	Warburg micro syndrome 3	Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.	NA	Belongs to the small GTPase superfamily. Rab family.	COPI-independent Golgi-to-ER retrograde traffic;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	10
+NX_Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	1137	126056	6.28	0	Endoplasmic reticulum	Epileptic encephalopathy, early infantile, 36	May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway.;Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities.	NA	Belongs to the glycosyltransferase 28 family.	N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)	PE1	X
+NX_Q9NP74	Palmdelphin	551	62758	5.31	0	Cytoplasm;Dendritic spine;Cell membrane;Focal adhesion;Dendrite;Cytoskeleton	NA	NA	Phosphorylated.	Belongs to the paralemmin family.	NA	PE1	1
+NX_Q9NP77	RNA polymerase II subunit A C-terminal domain phosphatase SSU72	194	22574	5.16	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.	NA	Belongs to the SSU72 phosphatase family.	RNA polymerase II transcribes snRNA genes	PE1	1
+NX_Q9NP78	ATP-binding cassette sub-family B member 9	766	84475	8	8	Cytoplasmic vesicle;Lysosome membrane	NA	ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.	NA	Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.	ABC transporters;Lysosome;ABC-family proteins mediated transport	PE1	12
+NX_Q9NP79	Vacuolar protein sorting-associated protein VTA1 homolog	307	33879	5.87	0	Cytoplasm;Endosome membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.	NA	Belongs to the VTA1 family.	Endocytosis;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT)	PE1	6
+NX_Q9NP80	Calcium-independent phospholipase A2-gamma	782	88477	9.31	1	Golgi apparatus;Endoplasmic reticulum membrane;Nucleoplasm;Golgi apparatus membrane;Cytosol;Perinuclear region;Cytoskeleton	Mitochondrial myopathy with lactic acidosis	Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.	NA	NA	Acyl chain remodelling of PC;Acyl chain remodelling of PE	PE1	7
+NX_Q9NP81	Serine--tRNA ligase, mitochondrial	518	58283	8.35	0	Mitochondrion matrix;Cytoplasmic vesicle;Nucleoplasm;Mitochondrion	Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome	Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).	NA	Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.	Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.;Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	19
+NX_Q9NP84	Tumor necrosis factor receptor superfamily member 12A	129	13911	9.37	1	Membrane;Cytosol;Cell membrane	NA	Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.	NA	NA	Cytokine-cytokine receptor interaction;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	PE1	16
+NX_Q9NP85	Podocin	383	42201	8.95	0	Endoplasmic reticulum;Cell membrane	Nephrotic syndrome 2	Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.	Is glycosylated.	Belongs to the band 7/mec-2 family.	Nephrin family interactions	PE1	1
+NX_Q9NP86	Calcium-binding protein 5	173	19826	4.45	0	Cytoplasm	NA	Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (By similarity). Involved in the transmission of light signals (By similarity). May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (By similarity). May play a role in the extension and network organization of neurites (By similarity).	NA	NA	NA	PE1	19
+NX_Q9NP87	DNA-directed DNA/RNA polymerase mu	494	54816	8.74	0	Nucleoplasm;Nucleus	NA	Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.	NA	Belongs to the DNA polymerase type-X family.	Non-homologous end-joining;Nonhomologous End-Joining (NHEJ)	PE1	7
+NX_Q9NP90	Ras-related protein Rab-9B	201	22719	4.74	0	Phagosome membrane;Phagosome;Cell membrane	NA	Involved in the transport of proteins between the endosomes and the trans Golgi network.	NA	Belongs to the small GTPase superfamily. Rab family.	Measles;Retrograde transport at the Trans-Golgi-Network;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	X
+NX_Q9NP91	Sodium- and chloride-dependent transporter XTRP3	592	65914	6.25	12	Apical cell membrane	Iminoglycinuria;Hyperglycinuria	Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Involved in the transport of glycine.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily.	Amino acid transport across the plasma membrane;Na+/Cl- dependent neurotransmitter transporters;Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG);Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	PE1	3
+NX_Q9NP92	39S ribosomal protein S30, mitochondrial	439	50365	8.21	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL65 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	5
+NX_Q9NP94	Zinc transporter ZIP2	309	32742	5.85	8	Cytosol;Cell membrane	NA	Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.	NA	Belongs to the ZIP transporter (TC 2.A.5) family.	Zinc influx into cells by the SLC39 gene family	PE1	14
+NX_Q9NP95	Fibroblast growth factor 20	211	23499	8.89	0	Secreted	Renal hypodysplasia/aplasia 2	Neurotrophic factor that regulates central nervous development and function.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR1;Signaling by activated point mutants of FGFR3;FGFR4 ligand binding and activation;FGFR3c ligand binding and activation;FGFR1c ligand binding and activation;FGFR2c ligand binding and activation;FGFR3 mutant receptor activation;Activated point mutants of FGFR2;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;Phospholipase C-mediated cascade, FGFR2;Phospholipase C-mediated cascade, FGFR3;Phospholipase C-mediated cascade, FGFR4;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR1 in disease;FGFR3b ligand binding and activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1;Signaling by FGFR3 point mutants in cancer	PE1	8
+NX_Q9NP97	Dynein light chain roadblock-type 1	96	10922	6.58	0	Cytoplasm;Cytoskeleton	NA	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.	NA	Belongs to the GAMAD family.	Intraflagellar transport	PE1	20
+NX_Q9NP98	Myozenin-1	299	31745	8.86	0	Pseudopodium;Nucleus	NA	Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.	NA	Belongs to the myozenin family.	NA	PE1	10
+NX_Q9NP99	Triggering receptor expressed on myeloid cells 1	234	26387	9	1	Secreted;Cell membrane	NA	Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.	Glycosylated.	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall;DAP12 interactions	PE1	6
+NX_Q9NPA0	ER membrane protein complex subunit 7	242	26471	9.24	1	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the EMC7 family.	NA	PE1	15
+NX_Q9NPA1	Calcium-activated potassium channel subunit beta-3	279	31604	6.88	2	Membrane;Nucleoplasm;Mitochondrion	NA	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel.;Partially inactivate the current of KCNBMA.;Induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.	N-glycosylated.;The extracellular domain contains disulfide bond essential for the gating mechanism.	Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily.	Vascular smooth muscle contraction;Ca2+ activated K+ channels;cGMP effects	PE1	3
+NX_Q9NPA2	Matrix metalloproteinase-25	562	62554	8.76	0	Extracellular matrix;Cell membrane	NA	May activate progelatinase A.	The precursor is cleaved by a furin endopeptidase.	Belongs to the peptidase M10A family.	Activation of Matrix Metalloproteinases;Neutrophil degranulation	PE1	16
+NX_Q9NPA3	Mid1-interacting protein 1	183	20202	5.25	0	Cytoplasm;Nucleus;Cytoskeleton	NA	Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).	NA	Belongs to the SPOT14 family.	Import of palmitoyl-CoA into the mitochondrial matrix	PE1	X
+NX_Q9NPA8	Transcription and mRNA export factor ENY2	101	11529	9.39	0	Nucleoplasm;Mitochondrion;Nucleus;Nuclear pore complex	NA	Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820).	NA	Belongs to the ENY2 family.	HATs acetylate histones	PE1	8
+NX_Q9NPB0	SAYSvFN domain-containing protein 1	183	20163	8.95	1	Cytoplasmic vesicle membrane;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	6
+NX_Q9NPB1	5'(3')-deoxyribonucleotidase, mitochondrial	228	25862	8.21	0	Mitochondrion	NA	Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.	NA	Belongs to the 5'(3')-deoxyribonucleotidase family.	Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Pyrimidine catabolism	PE1	17
+NX_Q9NPB3	Calcium-binding protein 2	220	24482	4.6	0	Golgi apparatus;Perinuclear region;Cell membrane	Deafness, autosomal recessive, 93	Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs (PubMed:28183797). Required for the normal transfer of light signals through the retina (By similarity).	NA	NA	NA	PE1	11
+NX_Q9NPB6	Partitioning defective 6 homolog alpha	346	37388	9.29	0	Cytoplasm;Cell membrane;Cell junction;Centriolar satellite;Tight junction;Centrosome;Ruffle;Cytosol;Cytoskeleton	NA	Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959).	Phosphorylated by the TGF-beta receptor.	Belongs to the PAR6 family.	Endocytosis;Tight junction;Asymmetric localization of PCP proteins;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Tight junction interactions	PE1	16
+NX_Q9NPB8	Glycerophosphocholine phosphodiesterase GPCPD1	672	76035	5.34	0	Nucleoplasm;Cytosol	NA	May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.	NA	Belongs to the glycerophosphoryl diester phosphodiesterase family.	Hydrolysis of LPC;Hydrolysis of LPE	PE1	20
+NX_Q9NPB9	Atypical chemokine receptor 4	350	39914	8.8	7	Mitochondrion;Cell membrane;Recycling endosome;Early endosome;Cytoplasmic vesicle	NA	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.	The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.	Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.	Chemokine receptors bind chemokines	PE1	3
+NX_Q9NPC1	Leukotriene B4 receptor 2	358	37942	10.68	7	Nucleoplasm;Cell membrane	NA	Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Leukotriene receptors	PE2	14
+NX_Q9NPC2	Potassium channel subfamily K member 9	374	42264	8.85	4	Cell membrane	Birk-Barel mental retardation dysmorphism syndrome	PH-dependent, voltage-insensitive, background potassium channel protein.	NA	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	TWIK-releated acid-sensitive K+ channel (TASK);Phase 4 - resting membrane potential	PE1	8
+NX_Q9NPC3	E3 ubiquitin-protein ligase CCNB1IP1	277	31544	8.59	0	Nucleus;Chromosome	NA	E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.;Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.	Ubiquitinated; autoubiquitinated.;Phosphorylated by CDK1 on serine or threonine residues (in vitro).	NA	Protein modification; protein ubiquitination.	PE1	14
+NX_Q9NPC4	Lactosylceramide 4-alpha-galactosyltransferase	353	40499	9.16	1	Mitochondrion;Golgi apparatus membrane	NA	Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)) (PubMed:10748143). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143). Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P (PubMed:10747952).;(Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins.	NA	Belongs to the glycosyltransferase 32 family.	Glycolipid biosynthesis.;Glycosphingolipid biosynthesis - globo series;Metabolic pathways	PE1	22
+NX_Q9NPC6	Myozenin-2	264	29898	7.86	0	Nucleoplasm;Cytosol;Z line	Cardiomyopathy, familial hypertrophic 16	Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.	NA	Belongs to the myozenin family.	NA	PE1	4
+NX_Q9NPC7	Myoneurin	610	68682	8.56	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q9NPC8	Homeobox protein SIX2	291	32286	9.14	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration.	NA	Belongs to the SIX/Sine oculis homeobox family.	NA	PE1	2
+NX_Q9NPD3	Exosome complex component RRP41	245	26383	6.07	0	Cytoplasm;Nucleolus;Cytosol;Nucleus;Cytoskeleton	NA	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.	NA	Belongs to the RNase PH family.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;mRNA decay by 3' to 5' exoribonuclease;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	8
+NX_Q9NPD5	Solute carrier organic anion transporter family member 1B3	702	77403	9.01	12	Basolateral cell membrane;Cell membrane	Hyperbilirubinemia, Rotor type	Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.	N-glycosylated.	Belongs to the organo anion transporter (TC 2.A.60) family.	Bile secretion;Transport of organic anions;Recycling of bile acids and salts;Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	PE1	12
+NX_Q9NPD7	Neuritin	142	15333	6.54	0	Synapse;Cell membrane	NA	Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.	NA	Belongs to the neuritin family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	6
+NX_Q9NPD8	Ubiquitin-conjugating enzyme E2 T	197	22521	7.78	0	Nucleoplasm;Nucleolus;Nucleus	Fanconi anemia complementation group T	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386).	Auto-ubiquitinated. Effects of auto-monoubiquitination at Lys-91 and Lys-182 are unclear: according to a report, monoubiquitination inactivates E2 enzyme activity (PubMed:16916645). In contrast, according to another report, autoubiquitination does not affect E2 enzyme activity (PubMed:19111657).	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Fanconi anemia pathway;Fanconi Anemia Pathway;Synthesis of active ubiquitin: roles of E1 and E2 enzymes	PE1	1
+NX_Q9NPE2	Neugrin	291	32408	9.16	0	Cytoplasm;Mitochondrion;Secreted;Nucleoplasm;Mitochondrion membrane;Nucleus;Cytoskeleton	NA	Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.	NA	Belongs to the neugrin family.	NA	PE1	15
+NX_Q9NPE3	H/ACA ribonucleoprotein complex subunit 3	64	7706	10.01	0	Cajal body;Nucleus;Nucleolus	Dyskeratosis congenita, autosomal recessive, 1	Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.	NA	Belongs to the NOP10 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol	PE1	15
+NX_Q9NPE6	Sperm-associated antigen 4 protein	437	48165	6.65	2	Flagellum axoneme;Membrane;Nucleus inner membrane;Nucleus envelope;Cytoskeleton	NA	Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail.	NA	NA	NA	PE1	20
+NX_Q9NPF0	CD320 antigen	282	28991	4.61	1	Endoplasmic reticulum;Cytosol;Cell membrane	Methylmalonic aciduria, transient, due to transcobalamin receptor defect	Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631).	NA	NA	Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective CD320 causes methylmalonic aciduria	PE1	19
+NX_Q9NPF2	Carbohydrate sulfotransferase 11	352	41555	9.04	1	Golgi apparatus;Golgi apparatus membrane	Osteochondrodysplasia, brachydactyly, and overlapping malformed digits	Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.	N-glycosylated; required for activity and stability.	Belongs to the sulfotransferase 2 family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Sulfur metabolism;Chondroitin sulfate biosynthesis	PE1	12
+NX_Q9NPF4	Probable tRNA N6-adenosine threonylcarbamoyltransferase	335	36427	5.94	0	Cytoplasm;Nucleoplasm;Nucleus;Cell membrane	Galloway-Mowat syndrome 3	Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	NA	Belongs to the KAE1 / TsaD family.	tRNA modification in the nucleus and cytosol	PE1	14
+NX_Q9NPF5	DNA methyltransferase 1-associated protein 1	467	52993	9.51	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.	NA	NA	HATs acetylate histones	PE1	1
+NX_Q9NPF7	Interleukin-23 subunit alpha	189	20730	6.02	0	Cytosol;Secreted	NA	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.	NA	Belongs to the IL-6 superfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Pertussis;Tuberculosis;Rheumatoid arthritis;Interleukin-4 and Interleukin-13 signaling;Interleukin-23 signaling	PE1	12
+NX_Q9NPF8	Arf-GAP with dual PH domain-containing protein 2	381	44349	9.44	0	Cytoplasm;Cell membrane	NA	GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.	NA	NA	NA	PE1	17
+NX_Q9NPG1	Frizzled-3	666	76263	7.94	7	Cell surface;Apical cell membrane;Membrane;Cell membrane	NA	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.	Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Asymmetric localization of PCP proteins;Class B/2 (Secretin family receptors);PCP/CE pathway;Ca2+ pathway	PE1	8
+NX_Q9NPG2	Neuroglobin	151	16933	5.42	0	Cytoplasm;Perikaryon;Mitochondrion	NA	Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.	A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO.;Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity.	Belongs to the globin family.	Intracellular oxygen transport	PE1	14
+NX_Q9NPG3	Ubinuclein-1	1134	121520	9.37	0	Nucleus;Nucleoplasm;Tight junction;PML body	NA	Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.	NA	Belongs to the ubinuclein family.	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	PE1	16
+NX_Q9NPG4	Protocadherin-12	1184	128995	5.13	1	Cell junction;Secreted;Cell membrane	Microcephaly, seizures, spasticity, and brain calcifications	Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).	Protocadherin-12: Cleaved by ADAM10 close to the transmembrane domain to release the Protocadherin-12, secreted form in the serum. Cleavage results in reduced cellular adhesion in a cell migration assay.	NA	NA	PE1	5
+NX_Q9NPG8	Probable palmitoyltransferase ZDHHC4	344	39787	7.01	5	Endoplasmic reticulum membrane;Nucleus	NA	NA	NA	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	7
+NX_Q9NPH0	Lysophosphatidic acid phosphatase type 6	428	48886	6.04	0	Mitochondrion	NA	Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.	NA	Belongs to the histidine acid phosphatase family.	Riboflavin metabolism;Synthesis of PA	PE1	1
+NX_Q9NPH2	Inositol-3-phosphate synthase 1	558	61068	5.52	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.	NA	Belongs to the myo-inositol 1-phosphate synthase family.	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.;Inositol phosphate metabolism;Metabolic pathways;Synthesis of IP2, IP, and Ins in the cytosol	PE1	19
+NX_Q9NPH3	Interleukin-1 receptor accessory protein	570	65418	8.37	1	Cytoplasmic vesicle;Cytosol;Secreted;Cell membrane	NA	Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).;Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).;Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).	NA	Belongs to the interleukin-1 receptor family.	Cytokine-cytokine receptor interaction;Apoptosis;PIP3 activates AKT signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Receptor-type tyrosine-protein phosphatases;Interleukin-33 signaling;Interleukin-36 pathway;Interleukin-1 signaling	PE1	3
+NX_Q9NPH5	NADPH oxidase 4	578	66932	8.96	6	Endoplasmic reticulum membrane;Cell membrane;Focal adhesion;Nucleolus;Nucleoplasm;Nucleus	NA	Display reduced activity.;Is not functional.;Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation.;Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.	Glycosylation is required for its proper function.;Are N-glycosylated.	NA	Detoxification of Reactive Oxygen Species	PE1	11
+NX_Q9NPH6	Odorant-binding protein 2b	170	19457	8.91	0	Secreted	NA	Probably binds and transports small hydrophobic volatile molecules.	NA	Belongs to the calycin superfamily. Lipocalin family.	NA	PE1	9
+NX_Q9NPH9	Interleukin-26	171	19843	10	0	Secreted	NA	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.	NA	Belongs to the IL-10 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling	PE1	12
+NX_Q9NPI0	Transmembrane protein 138	162	19262	9.67	4	Vacuole membrane;Cilium;Cytoskeleton	Joubert syndrome 16	Required for ciliogenesis.	NA	Belongs to the TMEM138 family.	NA	PE1	11
+NX_Q9NPI1	Bromodomain-containing protein 7	651	74139	6	0	Nucleoplasm;Cytosol;Nucleus	NA	Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.	NA	NA	Regulation of TP53 Activity through Acetylation	PE1	16
+NX_Q9NPI5	Nicotinamide riboside kinase 2	230	26046	5.77	0	Nucleoplasm;Cytoplasmic vesicle	NA	Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.	NA	Belongs to the uridine kinase family. NRK subfamily.	Cofactor biosynthesis; NAD(+) biosynthesis.;Nicotinate and nicotinamide metabolism;Nicotinate metabolism	PE1	19
+NX_Q9NPI6	mRNA-decapping enzyme 1A	582	63278	5.84	0	Cytosol;P-body;Nucleus	NA	Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.	NA	Belongs to the DCP1 family.	RNA degradation;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);mRNA decay by 5' to 3' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	PE1	3
+NX_Q9NPI7	Lysine-rich coiled-coil protein 1	259	30980	9.35	0	Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	2
+NX_Q9NPI8	Fanconi anemia group F protein	374	42254	9.11	0	Nucleoplasm;Nucleus	Fanconi anemia complementation group F	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).	NA	NA	Fanconi anemia pathway;Fanconi Anemia Pathway	PE1	11
+NX_Q9NPI9	Inward rectifier potassium channel 16	418	47949	7.98	2	Membrane;Basolateral cell membrane;Cytoplasmic vesicle	NA	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201).	NA	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily.	Gastric acid secretion;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Potassium transport channels	PE1	17
+NX_Q9NPJ1	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin	570	62342	6.67	0	Cytoplasm;Cytosol;Centrosome;Nucleus	Bardet-Biedl syndrome 6;McKusick-Kaufman syndrome	Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis (PubMed:28753627).	NA	Belongs to the TCP-1 chaperonin family.	BBSome-mediated cargo-targeting to cilium	PE1	20
+NX_Q9NPJ3	Acyl-coenzyme A thioesterase 13	140	14960	9.23	0	Mitochondrion;Cell junction;Cytosol;Spindle;Nucleus	NA	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity).	NA	Belongs to the thioesterase PaaI family.	Mitochondrial Fatty Acid Beta-Oxidation	PE1	6
+NX_Q9NPJ4	Proline-rich nuclear receptor coactivator 2	139	15591	10.4	0	Golgi apparatus;Nucleoplasm;P-body;Nucleus	NA	Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).	NA	Belongs to the PNRC family. PNRC2 subfamily.	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PE1	1
+NX_Q9NPJ6	Mediator of RNA polymerase II transcription subunit 4	270	29745	5.02	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 4 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	13
+NX_Q9NPJ8	NTF2-related export protein 2	142	16228	5.24	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.	NA	NA	Ribosome biogenesis in eukaryotes;RNA transport;mRNA surveillance pathway;Influenza A	PE1	X
+NX_Q9NPL8	Complex I assembly factor TIMMDC1, mitochondrial	285	32178	8.65	4	Mitochondrion membrane;Nucleoplasm;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 31	Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I.	NA	Belongs to the Tim17/Tim22/Tim23 family.	Complex I biogenesis	PE1	3
+NX_Q9NPP4	NLR family CARD domain-containing protein 4	1024	116159	6.32	0	Cytoplasm;Cytosol	Autoinflammation with infantile enterocolitis;Familial cold autoinflammatory syndrome 4	Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).	Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro.	NA	NOD-like receptor signaling pathway;Salmonella infection;Legionellosis;The IPAF inflammasome;TP53 Regulates Transcription of Caspase Activators and Caspases	PE1	2
+NX_Q9NPQ8	Synembryn-A	531	59710	5.2	0	Cytoplasm;Cytosol;Cell membrane	NA	Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.	NA	Belongs to the synembryn family.	NA	PE1	11
+NX_Q9NPR2	Semaphorin-4B	837	92766	6.64	1	Membrane;Nucleoplasm;Cell junction;Cytoplasmic vesicle	NA	Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.	NA	Belongs to the semaphorin family.	NA	PE1	15
+NX_Q9NPR9	Protein GPR108	543	60633	8.88	7	Membrane;Golgi apparatus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the LU7TM family.	NA	PE1	19
+NX_Q9NPU4	Uncharacterized protein C14orf132	83	8830	3.8	1	Membrane	NA	NA	NA	NA	NA	PE2	14
+NX_Q9NPY3	Complement component C1q receptor	652	68560	5.27	1	Membrane;Golgi apparatus;Cytoplasmic vesicle;Cell membrane	NA	Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.	N- and O-glycosylated.	NA	Neutrophil degranulation	PE1	20
+NX_Q9NPZ5	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2	323	36919	10.63	1	Golgi apparatus membrane	NA	Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins.	NA	Belongs to the glycosyltransferase 43 family.	Protein modification; protein glycosylation.;Glycosaminoglycan biosynthesis - chondroitin sulfate;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;A tetrasaccharide linker sequence is required for GAG synthesis	PE1	6
+NX_Q9NQ03	Transcriptional repressor scratch 2	307	32584	9.39	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the snail C2H2-type zinc-finger protein family.	NA	PE2	20
+NX_Q9NQ11	Cation-transporting ATPase 13A2	1180	128794	8.47	12	Membrane;Lysosome membrane;Lysosome	Kufor-Rakeb syndrome;Spastic paraplegia 78, autosomal recessive	ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Required for a proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957). Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels (PubMed:27278822).	Autophosphorylated.	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.	Ion transport by P-type ATPases	PE1	1
+NX_Q9NQ25	SLAM family member 7	335	37421	6.02	1	Membrane;Endoplasmic reticulum;Cytoplasmic vesicle	NA	Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2.;Does not mediate any NK cell activation.;Mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	1
+NX_Q9NQ29	Putative RNA-binding protein Luc7-like 1	371	43728	9.95	0	Nucleoplasm;Mitochondrion	NA	May bind to RNA via its Arg/Ser-rich domain.	NA	Belongs to the Luc7 family.	NA	PE1	16
+NX_Q9NQ30	Endothelial cell-specific molecule 1	184	20095	7.36	0	Secreted	NA	Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.	May contain intrachain disulfide bonds.;O-glycosylated; contains chondroitin sulfate and dermatan sulfate.	NA	NA	PE1	5
+NX_Q9NQ31	A-kinase-interacting protein 1	210	23114	8.31	0	Nucleoplasm;Nucleus	NA	Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.	NA	NA	NA	PE1	11
+NX_Q9NQ32	Uncharacterized protein C11orf16	467	51609	8.45	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_Q9NQ33	Achaete-scute homolog 3	180	20797	8.71	0	Nucleus	NA	Transcriptional repressor. Inhibits myogenesis (By similarity).	NA	NA	NA	PE2	11
+NX_Q9NQ34	Transmembrane protein 9B	198	22531	8.35	1	Early endosome membrane;Lysosome membrane	NA	Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways.	N-glycosylated.	Belongs to the TMEM9 family.	NA	PE1	11
+NX_Q9NQ35	Nuclear receptor-interacting protein 3	241	26975	8.82	0	Cytoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	11
+NX_Q9NQ36	Signal peptide, CUB and EGF-like domain-containing protein 2	999	109957	6.21	0	Cell surface;Secreted	NA	Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).	N-glycosylated.	NA	Release of Hh-Np from the secreting cell	PE1	11
+NX_Q9NQ38	Serine protease inhibitor Kazal-type 5	1064	120714	8.45	0	Cytoplasmic vesicle;Secreted	Netherton syndrome	Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.	Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases.	NA	Formation of the cornified envelope	PE1	5
+NX_Q9NQ39	Putative 40S ribosomal protein S10-like	176	20120	10.13	0	NA	NA	NA	NA	Belongs to the eukaryotic ribosomal protein eS10 family.	NA	PE5	20
+NX_Q9NQ40	Solute carrier family 52, riboflavin transporter, member 3	469	50805	5.46	11	Cytoplasm;Apical cell membrane;Nucleus membrane;Cell membrane	Brown-Vialetto-Van Laere syndrome 1;Fazio-Londe disease	Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:20463145, PubMed:22273710, PubMed:24264046, PubMed:27702554). Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145).	NA	Belongs to the riboflavin transporter family.	Vitamin digestion and absorption;Vitamin B2 (riboflavin) metabolism	PE1	20
+NX_Q9NQ48	Leucine zipper transcription factor-like protein 1	299	34592	5.3	0	Cytoplasm;Cytosol	Bardet-Biedl syndrome 17	Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.	NA	Belongs to the LZTFL1 family.	BBSome-mediated cargo-targeting to cilium	PE1	3
+NX_Q9NQ50	39S ribosomal protein L40, mitochondrial	206	24490	9.62	0	Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL40 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	22
+NX_Q9NQ55	Suppressor of SWI4 1 homolog	473	53194	10.13	0	Nucleolus	NA	May have a role in cell growth.	NA	NA	NA	PE1	19
+NX_Q9NQ60	Equatorin	294	32840	4.89	1	Acrosome membrane;Acrosome inner membrane;Acrosome outer membrane	NA	Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis.	Highly N- and O-glycosylated; contains sialic acid.	NA	NA	PE1	9
+NX_Q9NQ66	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	1216	138567	5.9	0	Cytoplasm;Nucleus membrane;Cell membrane	Epileptic encephalopathy, early infantile, 12	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Chemokine signaling pathway;Phosphatidylinositol signaling system;Vascular smooth muscle contraction;Wnt signaling pathway;Gap junction;Long-term potentiation;Glutamatergic synapse;Cholinergic synapse;Dopaminergic synapse;Long-term depression;GnRH signaling pathway;Melanogenesis;Endocrine and other factor-regulated calcium reabsorption;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Alzheimer's disease;Huntington's disease;Chagas disease (American trypanosomiasis);African trypanosomiasis;Amoebiasis;G alpha (q) signalling events;Ca2+ pathway;G beta:gamma signalling through PLC beta;Presynaptic function of Kainate receptors;Synthesis of IP3 and IP4 in the cytosol;PLC beta mediated events;Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion;Acetylcholine regulates insulin secretion	PE1	20
+NX_Q9NQ69	LIM/homeobox protein Lhx9	397	43976	9	0	Nucleoplasm;Nucleus	NA	Involved in gonadal development.	NA	NA	Regulation of expression of SLITs and ROBOs	PE1	1
+NX_Q9NQ75	Cas scaffolding protein family member 4	786	87144	6.66	0	Focal adhesion;Cytoskeleton	NA	Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading.	Phosphorylated on tyrosines by SRC.	Belongs to the CAS family.	NA	PE1	20
+NX_Q9NQ76	Matrix extracellular phosphoglycoprotein	525	58419	8.62	0	Extracellular matrix	NA	Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (PubMed:14962809, PubMed:19005008). Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:18162525, PubMed:19998030, PubMed:22766095). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation (PubMed:22341070).	Phosphorylated on serine residues in the ASARM motif (in vitro) by FAM20C; the phosphorylation is important for the inhibition of bone mineralization (PubMed:19998030, PubMed:22582013).;Cleaved by CTSB/cathepsin B; the cleavage is blocked by metalloprotease PHEX.	Belongs to the PF07175/osteoregulin family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	4
+NX_Q9NQ79	Cartilage acidic protein 1	661	71421	4.95	0	Extracellular matrix	NA	NA	O-glycosylated.	NA	NA	PE1	10
+NX_Q9NQ84	G-protein coupled receptor family C group 5 member C	441	48193	8.72	7	Cell membrane;Centriolar satellite;Nucleoplasm;Cytoplasmic vesicle membrane;Cytosol	NA	This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.	NA	Belongs to the G-protein coupled receptor 3 family.	NA	PE1	17
+NX_Q9NQ86	E3 ubiquitin-protein ligase TRIM36	728	83013	5.77	0	Cytoplasm;Acrosome;Nucleoplasm;Cytosol;Cytoskeleton	Anencephaly	E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization.	NA	Belongs to the TRIM/RBCC family.	Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	5
+NX_Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	328	35087	10.69	0	Cytosol;Mitochondrion;Nucleus	NA	Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.	NA	Belongs to the HEY family.	NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH3 Intracellular Domain Regulates Transcription	PE1	1
+NX_Q9NQ88	Fructose-2,6-bisphosphatase TIGAR	270	30063	7.6	0	Cytoplasm;Cytosol;Mitochondrion;Nucleus	NA	Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:23726973, PubMed:22887998, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973).	NA	Belongs to the phosphoglycerate mutase family.	Fructose and mannose metabolism;TP53 Regulates Metabolic Genes	PE1	12
+NX_Q9NQ89	Protein C12orf4	552	63801	5.94	0	Cytoplasm;Nucleus	Mental retardation, autosomal recessive 66	Plays a role in mast cell degranulation.	NA	NA	NA	PE1	12
+NX_Q9NQ90	Anoctamin-2	1003	113969	6.12	8	Nucleoplasm;Cell membrane	NA	Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.	NA	Belongs to the anoctamin family.	Stimuli-sensing channels	PE1	12
+NX_Q9NQ92	Coordinator of PRMT5 and differentiation stimulator	184	20066	4.06	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).	NA	NA	RMTs methylate histone arginines	PE1	17
+NX_Q9NQ94	APOBEC1 complementation factor	594	65202	8.6	0	Endoplasmic reticulum;Nucleoplasm;Cytoplasm;Nucleus	NA	Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.	NA	NA	mRNA Editing: C to U Conversion;Formation of the Editosome	PE1	10
+NX_Q9NQA3	WAS protein family homolog 6	447	47990	5.48	0	Early endosome membrane;Recycling endosome membrane	NA	May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.	NA	Belongs to the WASH1 family.	NA	PE1	X
+NX_Q9NQA5	Transient receptor potential cation channel subfamily V member 5	729	82551	6.01	6	Apical cell membrane	NA	Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).	Glycosylated.	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.	Endocrine and other factor-regulated calcium reabsorption;TRP channels	PE1	7
+NX_Q9NQB0	Transcription factor 7-like 2	619	67919	8.73	0	Nucleoplasm;Cytosol;PML body;Nucleus	Diabetes mellitus, non-insulin-dependent	Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.	In vitro, phosphorylated by TNIK.;Phosphorylated at Thr-201 and/or Thr-212 by NLK. Phosphorylation by NLK at these sites inhibits DNA-binding by TCF7L2/TCF4, thereby preventing transcriptional activation of target genes of the canonical Wnt/beta-catenin signaling pathway.;Polysumoylated. Sumoylation is enhanced by PIAS family members and desumoylation is enhanced by SENP2. Sumoylation/desumoylation regulates TCF7L2/TCF4 transcription activity in the Wnt/beta-catenin signaling pathway without altering interaction with CTNNB1 nor binding to DNA.	Belongs to the TCF/LEF family.	Wnt signaling pathway;Adherens junction;Melanogenesis;Pathways in cancer;Colorectal cancer;Endometrial cancer;Prostate cancer;Thyroid cancer;Basal cell carcinoma;Acute myeloid leukemia;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Formation of the beta-catenin:TCF transactivating complex;Ca2+ pathway;Deactivation of the beta-catenin transactivating complex;Binding of TCF/LEF:CTNNB1 to target gene promoters;Repression of WNT target genes;TCF7L2 mutants don't bind CTBP;RUNX3 regulates WNT signaling	PE1	10
+NX_Q9NQC1	E3 ubiquitin-protein ligase Jade-2	790	87466	5.15	0	Nucleoplasm	NA	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo (PubMed:16387653). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity).	NA	Belongs to the JADE family.	Protein modification; protein ubiquitination.;HATs acetylate histones	PE1	5
+NX_Q9NQC3	Reticulon-4	1192	129931	4.43	2	Endoplasmic reticulum membrane;Cell membrane;Cell junction;Nucleus membrane;Endoplasmic reticulum	NA	Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550).;Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:27619977, PubMed:25612671, PubMed:24262037). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977, PubMed:25612671, PubMed:24262037, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable).;Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity).;Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550).	NA	NA	Axonal growth inhibition (RHOA activation)	PE1	2
+NX_Q9NQC7	Ubiquitin carboxyl-terminal hydrolase CYLD	956	107316	5.42	0	Cytoplasm;Cell membrane;Centriolar satellite;Cilium basal body;Nucleoplasm;Centrosome;Spindle;Perinuclear region;Cytoskeleton	Multiple familial trichoepithelioma 1;Cylindromatosis, familial;Brooke-Spiegler syndrome	Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18636086, PubMed:26670046, PubMed:27458237, PubMed:26997266, PubMed:27591049, PubMed:29291351, PubMed:18313383). Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26997266, PubMed:26670046, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351).	Ubiquitinated. Polyubiquitinated in hepatocytes treated with palmitic acid. Ubiquitination is mediated by E3 ligase TRIM47 and leads to proteasomal degradation.;Phosphorylated on several serine residues by IKKA and/or IKKB in response to immune stimuli. Phosphorylation requires IKBKG. Phosphorylation abolishes TRAF2 deubiquitination, interferes with the activation of Jun kinases, and strongly reduces CD40-dependent gene activation by NF-kappa-B.	Belongs to the peptidase C19 family.	Osteoclast differentiation;RIG-I-like receptor signaling pathway;NOD1/2 Signaling Pathway;Negative regulators of DDX58/IFIH1 signaling;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases	PE1	16
+NX_Q9NQC8	Intraflagellar transport protein 46 homolog	304	34286	4.37	0	Cytoplasm;Cilium;Cilium basal body;Cytoskeleton	NA	Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity).	NA	Belongs to the IFT46 family.	Intraflagellar transport	PE1	11
+NX_Q9NQE7	Thymus-specific serine protease	514	55049	8.28	0	Cytoplasmic vesicle	NA	Protease that may play a role in T-cell development.	NA	Belongs to the peptidase S28 family.	NA	PE2	6
+NX_Q9NQE9	Histidine triad nucleotide-binding protein 3	182	20361	6.12	0	Cytoplasm;Mitochondrion;Nucleolus;Cytosol;Nucleus	NA	Hydrolyzes phosphoramidate and acyl-adenylate substrates.	NA	Belongs to the HINT family.	NA	PE1	6
+NX_Q9NQF3	Serine hydrolase-like protein	203	22471	6.64	0	NA	NA	Putative serine hydrolase.	NA	Belongs to the AB hydrolase superfamily.	NA	PE2	22
+NX_Q9NQG1	Protein MANBAL	85	9467	9.21	1	Membrane;Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the UPF0239 family.	NA	PE1	20
+NX_Q9NQG5	Regulation of nuclear pre-mRNA domain-containing protein 1B	326	36900	5.73	0	Nucleoplasm;Nucleus	NA	Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.	NA	Belongs to the UPF0400 (RTT103) family.	RNA polymerase II transcribes snRNA genes	PE1	20
+NX_Q9NQG6	Mitochondrial dynamics protein MID51	463	51293	7.55	1	Mitochondrion outer membrane;Mitochondrion;Cytoskeleton	NA	Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.	NA	Belongs to the SMCR7 family.	NA	PE1	22
+NX_Q9NQG7	Hermansky-Pudlak syndrome 4 protein	708	76919	5.26	0	Centrosome	Hermansky-Pudlak syndrome 4	Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991).	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	22
+NX_Q9NQH7	Xaa-Pro aminopeptidase 3	507	57034	6.37	0	Cytoplasm;Mitochondrion	Nephronophthisis-like nephropathy 1	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889). Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889).;Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.	NA	Belongs to the peptidase M24B family.	NA	PE1	22
+NX_Q9NQI0	Probable ATP-dependent RNA helicase DDX4	724	79308	5.62	0	Cytoplasm;Perinuclear region	NA	ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (By similarity).	NA	Belongs to the DEAD box helicase family. DDX4/VASA subfamily.	PIWI-interacting RNA (piRNA) biogenesis	PE1	5
+NX_Q9NQL2	Ras-related GTP-binding protein D	400	45588	4.76	0	Cytoplasm;Nucleoplasm;Centrosome;Lysosome;Nucleus	NA	Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.	NA	Belongs to the GTR/RAG GTP-binding protein family.	Macroautophagy;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;mTOR signalling;mTORC1-mediated signalling;Regulation of PTEN gene transcription	PE1	6
+NX_Q9NQL9	Doublesex- and mab-3-related transcription factor 3	472	51199	7	0	Nucleus	NA	Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity).	NA	Belongs to the DMRT family.	NA	PE1	9
+NX_Q9NQM4	Protein PIH1D3	214	24069	3.99	0	Cytoplasm	Ciliary dyskinesia, primary, 36, X-linked	Plays a role in cytoplasmic pre-assembly of axonemal dynein.	NA	Belongs to the PIH1 family.	NA	PE1	X
+NX_Q9NQN1	Olfactory receptor 2S2	319	35172	8.37	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	9
+NX_Q9NQP4	Prefoldin subunit 4	134	15314	4.42	0	Cytoplasm;Mitochondrion;Nucleus	NA	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.	NA	Belongs to the prefoldin subunit beta family.	Prefoldin mediated transfer of substrate to CCT/TriC	PE1	20
+NX_Q9NQQ7	Solute carrier family 35 member C2	365	40432	8.31	8	Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment membrane;cis-Golgi network membrane;Membrane;Nucleoplasm	NA	May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.	NA	Belongs to the TPT transporter family. SLC35C subfamily.	NA	PE1	20
+NX_Q9NQR1	N-lysine methyltransferase KMT5A	393	42890	9.69	0	Nucleoplasm;Cytosol;Nucleus;Chromosome	NA	Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.	Ubiquitinated and degraded by the DCX(DTL) complex.;Acetylated at Lys-172; does not change methyltransferase activity. Deacetylated at Lys-172 by SIRT2; does not change methyltransferase activity.	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.	Lysine degradation;PKMTs methylate histone lysines;Condensation of Prophase Chromosomes;Regulation of TP53 Activity through Methylation	PE1	12
+NX_Q9NQR4	Omega-amidase NIT2	276	30608	6.83	0	Cytoplasm;Cytosol;Centrosome	NA	Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle.	NA	Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.	Alanine, aspartate and glutamate metabolism;Neutrophil degranulation	PE1	3
+NX_Q9NQR7	Coiled-coil domain-containing protein 177	707	79739	10.74	0	NA	NA	NA	NA	NA	NA	PE1	14
+NX_Q9NQR9	Glucose-6-phosphatase 2	355	40580	8.64	9	Endoplasmic reticulum membrane	NA	May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).	N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome.	Belongs to the glucose-6-phosphatase family.	Carbohydrate biosynthesis; gluconeogenesis.;Glycolysis / Gluconeogenesis;Galactose metabolism;Starch and sucrose metabolism;Metabolic pathways;Insulin signaling pathway;Adipocytokine signaling pathway;Carbohydrate digestion and absorption;Gluconeogenesis	PE1	2
+NX_Q9NQS1	Cell death regulator Aven	362	38506	4.9	0	Endomembrane system;Centrosome;Cell membrane;Cytoskeleton	NA	Protects against apoptosis mediated by Apaf-1.	NA	NA	Formation of apoptosome;Regulation of the apoptosome activity	PE1	15
+NX_Q9NQS3	Nectin-3	549	61002	5.79	1	Centriolar satellite;Cell membrane;Postsynaptic cell membrane	NA	Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.	NA	Belongs to the nectin family.	Cell adhesion molecules (CAMs);Adherens junction;Adherens junctions interactions;Nectin/Necl trans heterodimerization	PE1	3
+NX_Q9NQS5	G-protein coupled receptor 84	396	43705	9.63	7	Cell membrane	NA	Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (s) signalling events;Neutrophil degranulation	PE1	12
+NX_Q9NQS7	Inner centromere protein	918	105429	9.46	0	Kinetochore;Nucleoplasm;Centromere;Nucleus;Spindle;Midbody	NA	Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428).	Phosphorylation by AURKB or AURKC at its C-terminal part is important for AURKB or AURKC activation by INCENP.;INCENP is phosphorylated by AURKB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the INCENP family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;SUMOylation of DNA replication proteins	PE1	11
+NX_Q9NQT4	Exosome complex component RRP46	235	25249	7.54	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.	NA	Belongs to the RNase PH family.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;mRNA decay by 3' to 5' exoribonuclease;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	19
+NX_Q9NQT5	Exosome complex component RRP40	275	29572	8.39	0	Nucleoplasm;Cytoplasm;Nucleus;Nucleolus	Pontocerebellar hypoplasia 1B	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5.	NA	Belongs to the RRP40 family.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;mRNA decay by 3' to 5' exoribonuclease;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	9
+NX_Q9NQT6	Fascin-3	498	56624	7.83	0	Cytoskeleton	NA	Acts as an actin bundling protein.	NA	Belongs to the fascin family.	NA	PE1	7
+NX_Q9NQT8	Kinesin-like protein KIF13B	1826	202789	5.64	0	Axon;Cytoskeleton	NA	Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.	Phosphorylated at Ser-1381 and Ser-1410 by MARK2, promoting interaction with 14-3-3 and inhibiting microtubule-dependent accumulation and formation of axons.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	8
+NX_Q9NQU5	Serine/threonine-protein kinase PAK 6	681	74869	9.57	0	Cytoplasm;Cell junction;Nucleolus;Nucleoplasm;Nucleus	NA	Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.	Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.;PAK6 is phosphorylated by MAP2K6 (Phosphotyrosine:PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	ErbB signaling pathway;Axon guidance;Focal adhesion;T cell receptor signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;Activation of RAC1	PE1	15
+NX_Q9NQV5	PR domain-containing protein 11	511	57863	5.85	0	Cytoplasm;Nucleus	NA	May be involved in transcription regulation.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE1	11
+NX_Q9NQV6	PR domain zinc finger protein 10	1147	130136	6.27	0	Nucleoplasm;Nucleolus;Nucleus;Cytoplasmic vesicle	NA	May be involved in transcriptional regulation.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE1	11
+NX_Q9NQV7	Histone-lysine N-methyltransferase PRDM9	894	103376	9.36	0	Nucleus;Chromosome	NA	Histone methyltransferase that methylates both dimethylated 'Lys-4' (H3K4me2) and dimethylated 'Lys-36' (H3K36me2) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:24634223, PubMed:24095733, PubMed:26833727). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:26833727). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (By similarity). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (By similarity). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (By similarity). In vitro sequentially mono-, di-, and trimethylates H3K4 and H3K36, but trimethylation of H3K36 is less efficiently than H3K4; also can methylate unmodified 'Lys-4' of histone H3 and all four core histones with H3 being the best substrate and the most highly modified (PubMed:24634223, PubMed:24095733, PubMed:26833727). Also able to trimethylate H3K9 and has highest substrate specificity towards di-methylated H3K9 (By similarity). In addition performs automethylation (By similarity). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (By similarity).	Mono-methylated; automethylated. Tri-methylated; automethylated. Mono-methylation is predominant; automethylation is lower and slower than H3 peptide methylation and is in a highest S-adenosyl-L-methionine concentration-dependent. There are two major sites for automethylation at Lys-368 and Lys-374. Lysines can be simultaneously methylated, such as Lys-368(me3)/Lys-372(me1), Lys-368(me1)/Lys-374(me1) and Lys-368(me1)/Lys-372(me1)/Lys-374(me1). Automethylation is an intramolecular (cis) process.	Belongs to the class V-like SAM-binding methyltransferase superfamily.	PKMTs methylate histone lysines;Meiotic recombination	PE1	5
+NX_Q9NQV8	PR domain zinc finger protein 8	689	71663	8.05	0	Nucleus	Epilepsy, progressive myoclonic 10	Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity).	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE1	4
+NX_Q9NQW1	Protein transport protein Sec31B	1179	128697	8.62	0	Cytoplasm;Endoplasmic reticulum membrane;Nucleoplasm;COPII-coated vesicle membrane;Cytoplasmic vesicle;Cytosol	NA	As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.	Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.	Belongs to the WD repeat SEC31 family.	Protein processing in endoplasmic reticulum	PE1	10
+NX_Q9NQW5	Probable histone-lysine N-methyltransferase PRDM7	492	55777	7.99	0	Nucleus speckle;Nucleus;Chromosome	NA	Probable histone methyltransferase.	NA	NA	Generic Transcription Pathway	PE1	16
+NX_Q9NQW6	Anillin	1124	124199	8.38	0	Cell cortex;Bleb;Nucleoplasm;Nucleus;Midbody;Cytoskeleton	Focal segmental glomerulosclerosis 8	Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636).	Ubiquitinated, and this requires FZR1/CDH1.;Phosphorylated during mitosis.	NA	NA	PE1	7
+NX_Q9NQW7	Xaa-Pro aminopeptidase 1	623	69918	5.42	0	Cytoplasm;Cytosol	NA	Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.	NA	Belongs to the peptidase M24B family.	NA	PE1	10
+NX_Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	809	92167	8.06	6	Membrane	Achromatopsia 3;Stargardt disease 1	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.	NA	Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily.	NA	PE1	8
+NX_Q9NQX0	Putative histone-lysine N-methyltransferase PRDM6	595	64452	7.93	0	Nucleoplasm;Nucleus	Patent ductus arteriosus 3	Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE1	5
+NX_Q9NQX1	PR domain zinc finger protein 5	630	73090	9.08	0	Nucleoplasm;Nucleus;Nucleolus	Brittle cornea syndrome 2	Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	NA	PE1	4
+NX_Q9NQX3	Gephyrin	736	79748	5.25	0	Cell membrane;Postsynaptic cell membrane;Postsynaptic density;Synapse;Cytosol;Dendrite;Cytoskeleton	Molybdenum cofactor deficiency, complementation group C	Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	NA	In the N-terminal section; belongs to the MoaB/Mog family.;In the C-terminal section; belongs to the MoeA family.	Cofactor biosynthesis; molybdopterin biosynthesis.;GABAergic synapse;Molybdenum cofactor biosynthesis	PE1	14
+NX_Q9NQX4	Unconventional myosin-Vc	1742	202810	7.69	0	Nucleoplasm;Cytosol	NA	May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	15
+NX_Q9NQX5	Neural proliferation differentiation and control protein 1	325	34516	6.55	1	Membrane;Nucleoplasm;Cytosol	NA	Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).	NA	Belongs to the NPDC1/cab-1 family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	9
+NX_Q9NQX6	Zinc finger protein 331	463	53739	9.16	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation. May play a role in spermatogenesis.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9NQX7	Integral membrane protein 2C	267	30224	8.16	1	Golgi apparatus;Lysosome membrane;Cell membrane	NA	Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).	Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembanaire cleavage by SPPL2B.	Belongs to the ITM2 family.	NA	PE1	2
+NX_Q9NQY0	Bridging integrator 3	253	29665	6.94	0	Cytoskeleton	NA	Involved in cytokinesis and septation where it has a role in the localization of F-actin.	NA	NA	NA	PE1	8
+NX_Q9NQZ2	Something about silencing protein 10	479	54558	5.5	0	Cytoplasmic vesicle;Nucleolus;Nucleus	NA	Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity).	Citrullinated by PADI4.	Belongs to the SAS10 family.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	4
+NX_Q9NQZ3	Deleted in azoospermia protein 1	744	82764	9.36	0	Cytoplasm;Nucleus	Spermatogenic failure Y-linked 2	RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells.	NA	Belongs to the RRM DAZ family.	NA	PE1	Y
+NX_Q9NQZ5	StAR-related lipid transfer protein 7, mitochondrial	370	43113	9.03	0	Mitochondrion	NA	May play a protective role in mucosal tissues by preventing exaggerated allergic responses.	NA	NA	Synthesis of PC	PE1	2
+NX_Q9NQZ6	Zinc finger C4H2 domain-containing protein	224	26244	6.68	0	Cytoplasm;Postsynaptic cell membrane;Cytoplasmic vesicle;Nucleus;Cytoskeleton	Wieacker-Wolf syndrome	Plays a role in interneurons differentiation (PubMed:26056227). Involved in neuronal development and in neuromuscular junction formation.	NA	NA	NA	PE1	X
+NX_Q9NQZ7	Ectonucleoside triphosphate diphosphohydrolase 7	604	68960	7.29	2	Cytoplasmic vesicle membrane;Nucleoplasm	NA	Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.	NA	Belongs to the GDA1/CD39 NTPase family.	Phosphate bond hydrolysis by NTPDase proteins	PE1	10
+NX_Q9NQZ8	Endothelial zinc finger protein induced by tumor necrosis factor alpha	489	54498	9	0	Nucleoplasm;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9NR00	Transcriptional and immune response regulator	106	12337	10.14	0	Cytoplasm;Nucleus speckle;Cell membrane;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).	NA	NA	NA	PE1	8
+NX_Q9NR09	Baculoviral IAP repeat-containing protein 6	4857	530255	5.67	0	Golgi apparatus;trans-Golgi network membrane;Spindle pole;Endosome;Centrosome;Cytoplasmic vesicle;Spindle;Midbody ring	NA	Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.	Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.	In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin mediated proteolysis	PE1	2
+NX_Q9NR11	Zinc finger protein 302	478	54814	9.13	0	Cytoplasmic vesicle;Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9NR12	PDZ and LIM domain protein 7	457	49845	8.76	0	Cytoplasm;Focal adhesion;Cytoskeleton	NA	May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. Embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. Embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity).	NA	NA	RET signaling	PE1	5
+NX_Q9NR16	Scavenger receptor cysteine-rich type 1 protein M160	1453	159239	5.44	1	Cell membrane;Secreted;Nucleoplasm;Centrosome;Cytosol	NA	NA	NA	NA	NA	PE1	12
+NX_Q9NR19	Acetyl-coenzyme A synthetase, cytoplasmic	701	78580	6.02	0	Nucleoplasm;Cytosol;Cytoplasmic vesicle	NA	Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity).	Reversibly acetylated at Lys-661 (By similarity). The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylases SIRT1 and SIRT3 (By similarity).	Belongs to the ATP-dependent AMP-binding enzyme family.	Glycolysis / Gluconeogenesis;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Transcriptional activation of mitochondrial biogenesis;Ethanol oxidation	PE1	20
+NX_Q9NR20	Dual specificity tyrosine-phosphorylation-regulated kinase 4	520	59608	9.03	0	Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	Possible non-essential role in spermiogenesis.	Autophosphorylation on Tyr-264 in the activation loop is required for kinase activity.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.	NA	PE1	12
+NX_Q9NR21	Protein mono-ADP-ribosyltransferase PARP11	338	39597	6.86	0	Nucleoplasm;Cytosol;Nucleus;Nuclear pore complex	NA	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity).	Auto-mono-ADP-ribosylated.	NA	NA	PE1	12
+NX_Q9NR22	Protein arginine N-methyltransferase 8	394	45291	6.47	0	Cell membrane	NA	S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed:18320585).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT8 subfamily.	NA	PE1	12
+NX_Q9NR23	Growth/differentiation factor 3	364	41387	8.2	0	Cytoplasm;Secreted	Microphthalmia, isolated, with coloboma, 6;Klippel-Feil syndrome 3, autosomal dominant;Microphthalmia, isolated, 7	Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089).	Synthesized as large precursor molecule that undergo proteolytic cleavage, releasing the pro-domain from the active, receptor binding, C-terminal region of the molecule.	Belongs to the TGF-beta family.	NA	PE1	12
+NX_Q9NR28	Diablo homolog, mitochondrial	239	27131	5.68	0	Mitochondrion	Deafness, autosomal dominant, 64	Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases.;Is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.;Also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation.;Attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway.	Ubiquitinated by BIRC7/livin.;DIABLO is phosphorylated by MAPK10 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Release of apoptotic factors from the mitochondria;SMAC (DIABLO) binds to IAPs;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes;Regulation of the apoptosome activity;SMAC, XIAP-regulated apoptotic response	PE1	12
+NX_Q9NR30	Nucleolar RNA helicase 2	783	87344	9.32	0	Mitochondrion;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity).	NA	Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.	Major pathway of rRNA processing in the nucleolus and cytosol;B-WICH complex positively regulates rRNA expression	PE1	10
+NX_Q9NR31	GTP-binding protein SAR1a	198	22367	6.22	0	Golgi apparatus;Endoplasmic reticulum	NA	Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).	NA	Belongs to the small GTPase superfamily. SAR1 family.	Protein processing in endoplasmic reticulum;Legionellosis	PE1	10
+NX_Q9NR33	DNA polymerase epsilon subunit 4	117	12209	4.87	0	Nucleoplasm;Cytosol;Nucleus	NA	Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity).	NA	NA	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;HTLV-I infection;Activation of the pre-replicative complex;Termination of translesion DNA synthesis;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Telomere C-strand synthesis initiation;DNA replication initiation;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER	PE1	2
+NX_Q9NR34	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	630	70911	7.01	1	Cytoplasmic vesicle;Nucleoplasm;Golgi apparatus membrane	NA	Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.	NA	Belongs to the glycosyl hydrolase 47 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2;Intra-Golgi traffic	PE1	1
+NX_Q9NR45	Sialic acid synthase	359	40308	6.29	0	Nucleoplasm	Spondyloepimetaphyseal dysplasia, Genevieve type	Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.	NA	NA	Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Sialic acid metabolism	PE1	9
+NX_Q9NR46	Endophilin-B2	395	43974	5.72	0	Nucleoplasm;Cytoplasm;Cytosol	NA	NA	NA	Belongs to the endophilin family.	Endocytosis	PE1	9
+NX_Q9NR48	Histone-lysine N-methyltransferase ASH1L	2969	332790	9.46	0	Golgi apparatus;Chromosome;Nucleoplasm;Tight junction;Nucleus	Mental retardation, autosomal dominant 52	Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me) (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity).	Methylated at Gln-1220 by N6AMT1.	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	Lysine degradation;Tight junction;PKMTs methylate histone lysines	PE1	1
+NX_Q9NR50	Translation initiation factor eIF-2B subunit gamma	452	50240	6.08	0	Cytoplasm;Cytosol;Cytoplasmic vesicle	Leukodystrophy with vanishing white matter	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.	NA	Belongs to the eIF-2B gamma/epsilon subunits family.	RNA transport;Recycling of eIF2:GDP	PE1	1
+NX_Q9NR55	Basic leucine zipper transcriptional factor ATF-like 3	127	14468	9.12	0	Nucleus	NA	AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.	NA	Belongs to the bZIP family.	NA	PE1	1
+NX_Q9NR56	Muscleblind-like protein 1	388	41817	9.16	0	Cytoplasm;Nucleoplasm;Cytosol;Cytoplasmic granule;Nucleus	Corneal dystrophy, Fuchs endothelial, 3;Dystrophia myotonica 1	Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.	NA	Belongs to the muscleblind family.	NA	PE1	3
+NX_Q9NR61	Delta-like protein 4	685	74605	6.51	1	Cell membrane	Adams-Oliver syndrome 6	Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).	NA	NA	Notch signaling pathway;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus	PE1	15
+NX_Q9NR63	Cytochrome P450 26B1	512	57513	8.68	0	Microsome membrane;Cytosol;Endoplasmic reticulum membrane	Radiohumeral fusions with other skeletal and craniofacial anomalies	Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.;Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.	NA	Belongs to the cytochrome P450 family.	Retinol metabolism;RA biosynthesis pathway;Vitamins;Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)	PE1	2
+NX_Q9NR64	Kelch-like protein 1	748	82680	5.95	0	Cytoskeleton	NA	May play a role in organizing the actin cytoskeleton of the brain cells.	NA	NA	NA	PE1	13
+NX_Q9NR71	Neutral ceramidase	780	85516	6.77	1	Extracellular exosome;Mitochondrion;Cell membrane;Secreted;Caveola;Golgi apparatus membrane;Membrane raft	NA	Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10781606, PubMed:16229686, PubMed:26190575). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:15946935, PubMed:19345744, PubMed:24798654). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:11278489, PubMed:17475390). Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:16061940). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity). This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (By similarity).	Proteolytic cleavage of the N-terminus removes the signal-anchor and produces a soluble form of the protein.;N-glycosylated. Required for enzyme activity.;O-glycosylated. Required to retain it as a type II membrane protein at the cell surface.;Phosphorylated. May prevent ubiquitination and subsequent degradation.;Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by nitric oxide.	Belongs to the neutral ceramidase family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Glycosphingolipid metabolism	PE1	10
+NX_Q9NR77	Peroxisomal membrane protein 2	195	22253	10.58	4	Peroxisome membrane	NA	Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.	NA	Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisome;Glyoxylate metabolism and glycine degradation;Class I peroxisomal membrane protein import	PE1	12
+NX_Q9NR80	Rho guanine nucleotide exchange factor 4	690	79067	6.55	0	Ruffle membrane;Cytoplasm	NA	Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.	NA	NA	Regulation of actin cytoskeleton;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	2
+NX_Q9NR81	Rho guanine nucleotide exchange factor 3	526	59783	6.03	0	Cytoplasm;Cytosol;Nucleus	NA	Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	3
+NX_Q9NR82	Potassium voltage-gated channel subfamily KQT member 5	932	102179	9.55	6	Cytoplasmic vesicle;Cell membrane	Mental retardation, autosomal dominant 46	Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.	NA	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily.	Cholinergic synapse;Voltage gated Potassium channels	PE1	6
+NX_Q9NR83	SLC2A4 regulator	387	41267	8.57	0	Cytoplasm;Nucleus speckle;Nucleus	NA	Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'.	NA	NA	NA	PE1	20
+NX_Q9NR90	Deleted in azoospermia protein 3	486	54989	8.9	0	Cytoplasm;Nucleus	Spermatogenic failure Y-linked 2	RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.	NA	Belongs to the RRM DAZ family.	NA	PE1	Y
+NX_Q9NR96	Toll-like receptor 9	1032	115860	8.55	1	Endosome;Endoplasmic reticulum membrane;Phagosome;Lysosome	NA	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366).	Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.	Belongs to the Toll-like receptor family.	Toll-like receptor signaling pathway;Chagas disease (American trypanosomiasis);African trypanosomiasis;Malaria;Tuberculosis;Measles;Herpes simplex infection;PI3K Cascade;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 dependent cascade initiated on endosome;Toll Like Receptor 9 (TLR9) Cascade;Trafficking and processing of endosomal TLR	PE1	3
+NX_Q9NR97	Toll-like receptor 8	1041	119828	6.2	1	Membrane	NA	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.	NA	Belongs to the Toll-like receptor family.	Toll-like receptor signaling pathway;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 dependent cascade initiated on endosome;Trafficking and processing of endosomal TLR;Toll Like Receptor 7/8 (TLR7/8) Cascade	PE1	X
+NX_Q9NR99	Matrix-remodeling-associated protein 5	2828	312150	8.57	0	Secreted	Lung cancer	In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli.	NA	NA	NA	PE1	X
+NX_Q9NRA0	Sphingosine kinase 2	654	69217	6.47	0	Cytoplasm;Lysosome membrane;Endoplasmic reticulum;Cytoplasmic vesicle;Mitochondrion inner membrane;Nucleus	NA	Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:19168031, PubMed:12954646). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Upregulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity).	Cleaved by CASP1 in apoptotic cells. The truncated form is released from cells.;Phosphorylated by PKD on Ser-419 and Ser-421 upon PMA treatment. Phosphorylation induces export from the nucleus to the cytoplasm (PubMed:17635916). Phosphorylated by MAPK1 and MAPK2 at Ser-387 and Thr-614, phosphorylation is induced by agonists such as EGF and PMA and increases kinase activity (PubMed:17311928).	NA	Sphingolipid metabolism;Metabolic pathways;Calcium signaling pathway;VEGF signaling pathway;Fc gamma R-mediated phagocytosis;Tuberculosis;Sphingolipid de novo biosynthesis	PE1	19
+NX_Q9NRA1	Platelet-derived growth factor C	345	39029	5.77	0	Cell membrane;Secreted;Cytosol;Cytoplasmic granule;Nucleus	NA	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.	N-glycosylated.;Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG.;Sumoylated with SUMO1.	Belongs to the PDGF/VEGF growth factor family.	Cytokine-cytokine receptor interaction;Focal adhesion;Gap junction;Regulation of actin cytoskeleton;Prostate cancer;Melanoma;Signaling by PDGF	PE1	4
+NX_Q9NRA2	Sialin	495	54640	8.51	12	Synaptic vesicle membrane;Cytosol;Lysosome membrane;Cell membrane	Salla disease;Infantile sialic acid storage disorder	Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.	NA	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.	Lysosome;Sialic acid metabolism;Organic anion transporters;Defective SLC17A5 causes Salla disease (SD) and ISSD	PE1	6
+NX_Q9NRA8	Eukaryotic translation initiation factor 4E transporter	985	108201	8.45	0	Cytoplasm;Nucleus speckle;PML body;Cytoplasmic vesicle;Nucleus	NA	Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.	NA	NA	NA	PE1	22
+NX_Q9NRB3	Carbohydrate sulfotransferase 12	414	48414	9.37	1	Golgi apparatus;Golgi apparatus membrane	NA	Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.	NA	Belongs to the sulfotransferase 2 family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Sulfur metabolism;Chondroitin sulfate biosynthesis	PE1	7
+NX_Q9NRC1	Suppressor of tumorigenicity 7 protein	585	67166	6.82	3	Membrane;Nucleoplasm;Cytosol	NA	May act as a tumor suppressor.	NA	Belongs to the ST7 family.	NA	PE1	7
+NX_Q9NRC6	Spectrin beta chain, non-erythrocytic 5	3674	416750	6.21	0	Cytoskeleton	NA	NA	NA	Belongs to the spectrin family.	RAF/MAP kinase cascade;Interaction between L1 and Ankyrins;NCAM signaling for neurite out-growth;COPI-mediated anterograde transport	PE1	15
+NX_Q9NRC8	NAD-dependent protein deacetylase sirtuin-7	400	44898	9.8	0	Cytoplasmic vesicle;Cytoplasm;Nucleolus	NA	NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.	Phosphorylated during mitosis.	Belongs to the sirtuin family. Class IV subfamily.	NA	PE1	17
+NX_Q9NRC9	Otoraplin	128	14332	4.87	0	Secreted	NA	NA	NA	Belongs to the MIA/OTOR family.	NA	PE1	20
+NX_Q9NRD0	F-box only protein 8	319	37068	7.62	0	Nucleoplasm;Cytosol	NA	May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).	NA	NA	NA	PE1	4
+NX_Q9NRD1	F-box only protein 6	293	33933	5.73	0	Cytoplasm	NA	Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.	NA	NA	Protein modification; protein ubiquitination.;Protein processing in endoplasmic reticulum;Antigen processing: Ubiquitination &amp; Proteasome degradation;Association of TriC/CCT with target proteins during biosynthesis;Neddylation	PE1	1
+NX_Q9NRD5	PRKCA-binding protein	415	46600	5.17	0	Mitochondrion;Synaptosome;Membrane;Postsynaptic density;Cytosol;Perinuclear region;Cytoskeleton	NA	Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.	Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.;Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD).	NA	Cell surface interactions at the vascular wall;Trafficking of GluR2-containing AMPA receptors	PE1	22
+NX_Q9NRD8	Dual oxidase 2	1548	175364	8.02	7	Apical cell membrane;Cell junction	Thyroid dyshormonogenesis 6	Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.	N-glycosylated.	In the N-terminal section; belongs to the peroxidase family.	Hormone biosynthesis; thyroid hormone biosynthesis.;Thyroxine biosynthesis	PE1	15
+NX_Q9NRD9	Dual oxidase 1	1551	177235	8.12	7	Apical cell membrane	NA	Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.	N-glycosylated.	In the N-terminal section; belongs to the peroxidase family.	Hormone biosynthesis; thyroid hormone biosynthesis.;Thyroxine biosynthesis	PE1	15
+NX_Q9NRE1	Matrix metalloproteinase-26	261	29708	5.96	0	Extracellular matrix	NA	May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.	NA	Belongs to the peptidase M10A family.	NA	PE1	11
+NX_Q9NRE2	Teashirt homolog 2	1034	115005	8	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).	Sumoylated.	Belongs to the teashirt C2H2-type zinc-finger protein family.	NA	PE1	20
+NX_Q9NRF2	SH2B adapter protein 1	756	79366	5.26	0	Membrane;Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity).	Phosphorylated on tyrosine residues in response to receptor kinase stimulation. Phosphorylated by RET.;SH2B1 is phosphorylated by FGFR3	Belongs to the SH2B adapter family.	Neurotrophin signaling pathway;Factors involved in megakaryocyte development and platelet production;Prolactin receptor signaling;Growth hormone receptor signaling;Signaling by Leptin	PE1	16
+NX_Q9NRF8	CTP synthase 2	586	65678	6.46	0	Nucleoplasm;Cytosol	NA	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.	NA	Belongs to the CTP synthase family.	Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.;Pyrimidine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	X
+NX_Q9NRF9	DNA polymerase epsilon subunit 3	147	16860	4.68	0	Nucleoplasm;Nucleolus;Nucleus	NA	Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (PubMed:10801849).	NA	NA	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;HTLV-I infection;Activation of the pre-replicative complex;Termination of translesion DNA synthesis;PCNA-Dependent Long Patch Base Excision Repair;Recognition of DNA damage by PCNA-containing replication complex;Telomere C-strand synthesis initiation;DNA replication initiation;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER	PE1	9
+NX_Q9NRG0	Chromatin accessibility complex protein 1	131	14711	4.99	0	Nucleoplasm;Nucleus	NA	Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.	NA	NA	NA	PE1	8
+NX_Q9NRG1	Phosphoribosyltransferase domain-containing protein 1	225	25674	5.76	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.	NA	Belongs to the purine/pyrimidine phosphoribosyltransferase family.	NA	PE1	10
+NX_Q9NRG4	N-lysine methyltransferase SMYD2	433	49688	6.27	0	Cytosol;Mitochondrion;Nucleus;Cytoskeleton	NA	Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	PKMTs methylate histone lysines;Regulation of TP53 Activity through Methylation	PE1	1
+NX_Q9NRG7	Epimerase family protein SDR39U1	293	31077	9.09	0	Nucleoplasm;Cytosol	NA	Putative NADP-dependent oxidoreductase.	NA	Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.	NA	PE1	14
+NX_Q9NRG9	Aladin	546	59574	7.26	0	Nuclear pore complex;Nucleus membrane;Spindle pole;Centrosome;Cytosol	Achalasia-addisonianism-alacrima syndrome	Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606).	NA	NA	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	12
+NX_Q9NRH1	Protein YAE1 homolog	226	25299	5.35	0	Cytoplasm;Cytosol;Nucleus	NA	The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:26182403).	NA	NA	NA	PE1	7
+NX_Q9NRH2	SNF-related serine/threonine-protein kinase	765	84276	6.62	0	Cell membrane;Cell junction;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.	Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.	NA	PE1	3
+NX_Q9NRH3	Tubulin gamma-2 chain	451	51092	5.5	0	Centrosome;Centriolar satellite	NA	Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).	Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.	Belongs to the tubulin family.	Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes	PE1	17
+NX_Q9NRI5	Disrupted in schizophrenia 1 protein	854	93611	5.96	0	Cytoplasm;Mitochondrion;Centrosome;Postsynaptic density;Cytoskeleton	Schizophrenia 9	Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.	Ubiquitinated. Ubiquitination with 'Lys-48'-linked polyubiquitin chains leads to its proteasomal degradation.	NA	NA	PE1	1
+NX_Q9NRI6	Putative peptide YY-2	33	3432	3.92	0	Secreted	NA	NA	NA	Belongs to the NPY family.	NA	PE5	17
+NX_Q9NRI7	Putative pancreatic polypeptide 2	21	2179	7.74	0	NA	NA	NA	NA	Belongs to the NPY family.	NA	PE5	17
+NX_Q9NRJ1	Protein MOST-1	99	11219	8.59	0	Microsome membrane;Cytoplasm;Endoplasmic reticulum membrane	NA	May be involved in cell survival, proliferation and progression of cancer cells.	NA	NA	NA	PE1	8
+NX_Q9NRJ2	Putative uncharacterized protein GSN-AS1	163	17657	10.93	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_Q9NRJ3	C-C motif chemokine 28	127	14280	10.23	0	Secreted	NA	Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Intestinal immune network for IgA production;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	5
+NX_Q9NRJ4	Tubby-related protein 4	1543	169000	7.49	0	Cytoplasm	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the TUB family.	Protein modification; protein ubiquitination.;Neddylation	PE1	6
+NX_Q9NRJ5	Poly(A) polymerase beta	636	71681	6.02	0	Nucleus	NA	NA	NA	Belongs to the poly(A) polymerase family.	mRNA surveillance pathway	PE1	7
+NX_Q9NRJ7	Protocadherin beta-16	776	84983	5	1	Membrane;Cytoplasmic vesicle;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9NRK6	ATP-binding cassette sub-family B member 10, mitochondrial	738	79148	9.87	5	Mitochondrion inner membrane	NA	May mediate critical mitochondrial transport functions related to heme biosynthesis.	NA	Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.	ABC transporters;Mitochondrial ABC transporters	PE1	1
+NX_Q9NRL2	Bromodomain adjacent to zinc finger domain protein 1A	1556	178702	6.2	0	Endoplasmic reticulum;Nucleus	NA	Component of the histone-fold protein complex CHRAC complex which facilitates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.;Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.	NA	Belongs to the WAL family.	NA	PE1	14
+NX_Q9NRL3	Striatin-4	753	80596	5.21	0	Membrane;Cytoplasm;Dendritic spine;Cytosol	NA	Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.	NA	Belongs to the WD repeat striatin family.	NA	PE1	19
+NX_Q9NRM0	Solute carrier family 2, facilitated glucose transporter member 9	540	58702	9.09	12	Basolateral cell membrane;Apical cell membrane	Hypouricemia renal 2	Urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:28083649). Does not transport glucose, fructose or galactose (PubMed:28083649).	NA	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Cellular hexose transport;Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)	PE1	4
+NX_Q9NRM1	Enamelin	1142	128785	6.36	0	Extracellular matrix	Amelogenesis imperfecta 1C;Amelogenesis imperfecta 1B	Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.	Phosphorylated by FAM20C in vitro.	NA	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	4
+NX_Q9NRM2	Zinc finger protein 277	450	52788	5.19	0	Nucleoplasm;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the ZNF277 family.	NA	PE1	7
+NX_Q9NRM6	Interleukin-17 receptor B	502	55885	8.44	1	Secreted;Cell membrane	NA	Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.	NA	NA	Cytokine-cytokine receptor interaction;Interleukin-17 signaling	PE1	3
+NX_Q9NRM7	Serine/threonine-protein kinase LATS2	1088	120136	8.44	0	Cytoplasm;Centriolar satellite;Spindle pole;Centrosome;Cytosol;Nucleus	NA	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.	Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and activated by STK3/MST2.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Signaling by Hippo	PE1	13
+NX_Q9NRN5	Olfactomedin-like protein 3	406	46010	6.17	0	Cytoplasmic vesicle;Secreted	NA	Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.	NA	Belongs to the OLFML3 family.	NA	PE1	1
+NX_Q9NRN7	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	309	35776	6.35	0	Cytoplasm	NA	Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.	NA	Belongs to the P-Pant transferase superfamily. AcpS family.	Pantothenate and CoA biosynthesis;Vitamin B5 (pantothenate) metabolism	PE1	11
+NX_Q9NRN9	Methyltransferase-like protein 5	209	23719	6.23	0	Cytosol;Nucleolus	NA	Probable methyltransferase.	NA	Belongs to the methyltransferase superfamily. PrmA family.	NA	PE1	2
+NX_Q9NRP0	Oligosaccharyltransferase complex subunit OSTC	149	16829	9.23	3	Membrane;Endoplasmic reticulum	NA	Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.	NA	Belongs to the OSTC family.	Protein modification; protein glycosylation.	PE1	4
+NX_Q9NRP2	COX assembly mitochondrial protein 2 homolog	79	9460	7.73	0	Mitochondrion	NA	May be involved in cytochrome c oxidase biogenesis.	NA	Belongs to the CMC family.	Mitochondrial protein import	PE1	16
+NX_Q9NRP4	Succinate dehydrogenase assembly factor 3, mitochondrial	125	14652	9.13	0	Mitochondrion matrix;Mitochondrion;Cytoskeleton	NA	Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.	NA	Belongs to the complex I LYR family. SDHAF3 subfamily.	NA	PE1	7
+NX_Q9NRP7	Serine/threonine-protein kinase 36	1315	143995	5.57	0	Cytoplasm;Cytosol;Nucleus	NA	Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	Hedgehog signaling pathway;Pathways in cancer;Basal cell carcinoma	PE1	2
+NX_Q9NRQ2	Phospholipid scramblase 4	329	37005	5.53	1	Membrane;Nucleoplasm;Nucleus	NA	May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.	NA	Belongs to the phospholipid scramblase family.	NA	PE1	3
+NX_Q9NRQ5	Single-pass membrane and coiled-coil domain-containing protein 4	59	6738	10.28	1	Membrane	NA	NA	NA	Belongs to the SMCO4 family.	NA	PE1	11
+NX_Q9NRR1	Cytokine-like protein 1	136	15577	8.81	0	Endoplasmic reticulum;Secreted;Nucleus membrane	NA	NA	NA	NA	NA	PE1	4
+NX_Q9NRR2	Tryptase gamma	321	33815	6.69	1	Membrane	NA	NA	NA	Belongs to the peptidase S1 family. Tryptase subfamily.	NA	PE2	16
+NX_Q9NRR3	CDC42 small effector protein 2	84	9223	8.61	0	Phagocytic cup;Cell membrane;Cytoskeleton	NA	Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.	NA	Belongs to the CDC42SE/SPEC family.	NA	PE1	5
+NX_Q9NRR4	Ribonuclease 3	1374	159316	8	0	Nucleolus;Nucleus	NA	Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.	NA	Belongs to the ribonuclease III family.	Ribosome biogenesis in eukaryotes;MicroRNA (miRNA) biogenesis	PE1	5
+NX_Q9NRR5	Ubiquilin-4	601	63853	5.14	0	Cytoplasm;Chromosome;Endoplasmic reticulum;Nucleoplasm;Autophagosome;Perinuclear region;Nucleus	Amyotrophic lateral sclerosis	Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205).	Phosphorylated by ATM at Ser-318 in response to DNA damage, leading to localization in the nucleus and recruitment to sites of DNA damage.;Ubiquitinated; this does not lead to proteasomal degradation (PubMed:15280365). May undergo both 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:15280365).	NA	Protein processing in endoplasmic reticulum	PE1	1
+NX_Q9NRR6	Phosphatidylinositol polyphosphate 5-phosphatase type IV	644	70205	9.16	0	Cytoplasm;Cell membrane;Golgi stack membrane;Cilium axoneme;Ruffle	Joubert syndrome 1;Mental retardation, truncal obesity, retinal dystrophy, and micropenis	Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10764818) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity).	NA	Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type IV family.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the Golgi membrane;ARL13B-mediated ciliary trafficking of INPP5E	PE1	9
+NX_Q9NRR8	CDC42 small effector protein 1	79	8925	10.03	0	Cell junction;Cell membrane;Cytoskeleton	NA	Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.	NA	Belongs to the CDC42SE/SPEC family.	NA	PE1	1
+NX_Q9NRS4	Transmembrane protease serine 4	437	48246	5.2	1	Membrane;Nucleoplasm;Cytosol	NA	Probable protease. Seems to be capable of activating ENaC (By similarity).	NA	Belongs to the peptidase S1 family.	Influenza A	PE1	11
+NX_Q9NRS6	Sorting nexin-15	342	38291	5.09	0	Cytoplasm;Cell membrane;Nucleolus;Membrane;Cytoplasmic vesicle membrane;Cytoplasmic vesicle;Cytosol	NA	May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.	NA	Belongs to the sorting nexin family.	NA	PE1	11
+NX_Q9NRU3	Metal transporter CNNM1	951	104351	5.91	4	Cytosol;Cell membrane	NA	Probable metal transporter.	NA	Belongs to the ACDP family.	NA	PE1	10
+NX_Q9NRV9	Heme-binding protein 1	189	21097	5.71	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle	NA	May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.	NA	Belongs to the HEBP family.	G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands	PE1	12
+NX_Q9NRW1	Ras-related protein Rab-6B	208	23462	5.41	0	Cytoplasmic vesicle;Endoplasmic reticulum-Golgi intermediate compartment;Golgi apparatus membrane	NA	Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.	NA	Belongs to the small GTPase superfamily. Rab family.	COPI-independent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network;RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs;RAB geranylgeranylation	PE1	3
+NX_Q9NRW3	DNA dC->dU-editing enzyme APOBEC-3C	190	22826	7.52	0	Cytoplasm;Nucleus;Cytoskeleton	NA	DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	mRNA Editing: C to U Conversion;Formation of the Editosome	PE1	22
+NX_Q9NRW4	Dual specificity protein phosphatase 22	184	20910	8.28	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).	Myristoylation regulates subcellular location, and is necessary for activation of JNK.	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway	PE1	6
+NX_Q9NRW7	Vacuolar protein sorting-associated protein 45	570	65077	8.41	0	Endosome membrane;Cytoskeleton;Golgi apparatus membrane	Neutropenia, severe congenital 5, autosomal recessive	May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.	NA	Belongs to the STXBP/unc-18/SEC1 family.	Endocytosis;Factors involved in megakaryocyte development and platelet production;Intra-Golgi traffic	PE1	1
+NX_Q9NRX1	RNA-binding protein PNO1	252	27924	9.75	0	Nucleoplasm;Nucleolus	NA	Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604).	NA	Belongs to the PNO1 family.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	2
+NX_Q9NRX2	39S ribosomal protein L17, mitochondrial	175	20050	10.12	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bL17 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	11
+NX_Q9NRX3	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	87	9966	9.94	0	NA	NA	NA	NA	Belongs to the complex I NDUFA4 subunit family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease	PE1	12
+NX_Q9NRX4	14 kDa phosphohistidine phosphatase	125	13833	5.65	0	Cytoplasm;Cytosol;Nucleus	NA	Exhibits phosphohistidine phosphatase activity.	NA	Belongs to the janus family.	Fructose and mannose metabolism	PE1	9
+NX_Q9NRX5	Serine incorporator 1	453	50495	5.59	10	Cytosol;Endoplasmic reticulum membrane	NA	Enhances the incorporation of serine into phosphatidylserine and sphingolipids.	NA	Belongs to the TDE1 family.	Serine biosynthesis	PE1	6
+NX_Q9NRX6	Protein kish-B	74	8294	9.67	1	Golgi apparatus membrane	NA	Involved in the early part of the secretory pathway.	NA	Belongs to the KISH family.	NA	PE1	1
+NX_Q9NRY2	SOSS complex subunit C	104	11425	9.22	0	Nucleoplasm;Nucleus	NA	Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.	NA	Belongs to the SOSS-C family.	NA	PE1	9
+NX_Q9NRY4	Rho GTPase-activating protein 35	1499	170514	6.2	0	Cytoplasm;Cell membrane;Cilium basal body;Cytosol;Nucleus	NA	Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621).	Phosphorylation of Tyr-1105 by PTK6 promotes the association with RASA1, inactivating RHOA while activating RAS. Phosphorylation at Tyr-308 by PDGFRA inhibits binding to GTF2I (PubMed:18829532, PubMed:19393245). Phosphorylated by PRKCA at Ser-1221 and Thr-1226, induces relocalization from the cytoplasm to regions of plasma membrane ruffling and prevents the binding and substrate specificity regulation by phospholipids (PubMed:19673492). In brain, phosphorylated by FYN and SRC (By similarity). During focal adhesion formation, phosphorylated by MAPK1 and MAPK3 at the C-terminal region, probably at Ser-1451, Ser-1476, Thr-1480 and Ser-1483. Phosphorylation by MAPK1 and MAPK3 inhibits GAP function and localizes ARGHAP35 away from newly forming focal adhesions and stress fibers in cells spreading on fibronectin (By similarity). Phosphorylation at Ser-1476 and Thr-1480 by GSK3B requires priming by MAPK and inhibits RhoGAP activity and modulates polarized cell migration (By similarity).	NA	Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Rho GTPase cycle;Sema4D mediated inhibition of cell attachment and migration;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	PE1	19
+NX_Q9NRY5	Protein FAM114A2	505	55468	4.85	0	Cytoplasmic vesicle	NA	NA	NA	Belongs to the FAM114 family.	Signaling by BRAF and RAF fusions	PE1	5
+NX_Q9NRY6	Phospholipid scramblase 3	295	31648	6.22	1	Mitochondrion membrane;Mitochondrion	NA	May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.	Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances flip-flop activity.;PLSCR3 is phosphorylated by PRKCD (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the phospholipid scramblase family.	NA	PE1	17
+NX_Q9NRY7	Phospholipid scramblase 2	297	33504	6.69	1	Membrane;Nucleus	NA	Has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.;May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.	NA	Belongs to the phospholipid scramblase family.	NA	PE1	3
+NX_Q9NRZ5	1-acyl-sn-glycerol-3-phosphate acyltransferase delta	378	44021	8.95	4	Golgi apparatus;Endoplasmic reticulum membrane;Nucleolus;Cytoplasmic vesicle	NA	Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity).	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.;Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PA	PE1	6
+NX_Q9NRZ7	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma	376	43381	8.96	2	Endoplasmic reticulum membrane;Nucleus envelope	NA	Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.;Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PA;COPI-independent Golgi-to-ER retrograde traffic	PE1	21
+NX_Q9NRZ9	Lymphoid-specific helicase	838	97074	8.07	0	Golgi apparatus;Cytoplasmic vesicle;Nucleoplasm;Nucleus	Immunodeficiency-centromeric instability-facial anomalies syndrome 4	Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).	NA	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	10
+NX_Q9NS00	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	363	42203	6.17	1	Membrane;Cytosol;Nucleus	NA	Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.	NA	Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins;Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	PE1	7
+NX_Q9NS15	Latent-transforming growth factor beta-binding protein 3	1303	139359	5.71	0	Nucleoplasm;Extracellular matrix;Secreted	Dental anomalies and short stature;Geleophysic dysplasia 3	Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.	Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix.;Contains hydroxylated asparagine residues.	Belongs to the LTBP family.	Molecules associated with elastic fibres	PE1	11
+NX_Q9NS18	Glutaredoxin-2, mitochondrial	164	18052	9.25	0	Cytoplasmic vesicle;Nucleoplasm;Mitochondrion;Nucleus	NA	Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.	NA	Belongs to the glutaredoxin family.	NA	PE1	1
+NX_Q9NS23	Ras association domain-containing protein 1	344	39219	9.2	0	Spindle pole;Centrosome;Spindle;Nucleus;Cytoskeleton	NA	Disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.;Interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein.;Has been shown not to perform these roles, no function has been identified for this isoform.;Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.	NA	NA	Pathways in cancer;Bladder cancer;Non-small cell lung cancer	PE1	3
+NX_Q9NS25	Sperm protein associated with the nucleus on the X chromosome B1	103	11840	5.92	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the SPAN-X family.	NA	PE1	X
+NX_Q9NS26	Sperm protein associated with the nucleus on the X chromosome A	97	11038	5.05	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the SPAN-X family.	NA	PE1	X
+NX_Q9NS28	Regulator of G-protein signaling 18	235	27582	7.73	0	Golgi apparatus;Cytoplasm	NA	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.	NA	NA	G alpha (i) signalling events;G alpha (q) signalling events	PE1	1
+NX_Q9NS37	CREB/ATF bZIP transcription factor	354	37134	5.12	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.	NA	Belongs to the bZIP family. ATF subfamily.	NA	PE1	11
+NX_Q9NS39	Double-stranded RNA-specific editase B2	739	80621	10.19	0	Nucleus	NA	Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA.	NA	NA	NA	PE1	10
+NX_Q9NS40	Potassium voltage-gated channel subfamily H member 7	1196	135000	7.57	6	Membrane	NA	Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.	NA	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily.	Voltage gated Potassium channels	PE1	2
+NX_Q9NS56	E3 ubiquitin-protein ligase Topors	1045	119198	9.56	0	Nucleoplasm;PML body;Nucleus	Retinitis pigmentosa 31	Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.	Sumoylated.;Phosphorylation at Ser-98 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the SUMO1-protein ligase activity resulting in increased p53/TP53 ubiquitination and degradation.	NA	SUMOylation of SUMOylation proteins;SUMOylation of transcription cofactors;SUMOylation of immune response proteins	PE1	9
+NX_Q9NS61	Kv channel-interacting protein 2	270	30907	4.97	0	Cytoplasm;Nucleus;Cell membrane	NA	Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).	Palmitoylated. Palmitoylation enhances association with the plasma membrane.	Belongs to the recoverin family.	Phase 1 - inactivation of fast Na+ channels	PE1	10
+NX_Q9NS62	Thrombospondin type-1 domain-containing protein 1	852	94584	8.33	1	Membrane;Cytosol;Secreted	NA	NA	NA	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	13
+NX_Q9NS64	Protein reprimo	109	11774	4.79	1	Membrane;Cytoplasm	NA	May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).	NA	Belongs to the reprimo family.	p53 signaling pathway	PE1	2
+NX_Q9NS66	Probable G-protein coupled receptor 173	373	41481	9.36	7	Cytosol;Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	X
+NX_Q9NS67	Probable G-protein coupled receptor 27	375	39818	9.3	7	Nucleoplasm;Cytosol;Cytoskeleton;Cell membrane	NA	Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (s) signalling events	PE2	3
+NX_Q9NS68	Tumor necrosis factor receptor superfamily member 19	423	46015	5.28	1	Membrane;Nucleoplasm;Mitochondrion	NA	Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.	NA	NA	Cytokine-cytokine receptor interaction	PE1	13
+NX_Q9NS69	Mitochondrial import receptor subunit TOM22 homolog	142	15522	4.27	1	Mitochondrion outer membrane;Mitochondrion	NA	Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (PubMed:10982837). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity).	NA	Belongs to the Tom22 family.	Mitochondrial protein import;Pink/Parkin Mediated Mitophagy	PE1	22
+NX_Q9NS71	Gastrokine-1	199	21999	5.9	0	Secreted	NA	Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.	NA	Belongs to the gastrokine family.	NA	PE1	2
+NX_Q9NS73	MAP3K12-binding inhibitory protein 1	344	39281	6.78	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.	NA	NA	HATs acetylate histones	PE1	14
+NX_Q9NS75	Cysteinyl leukotriene receptor 2	346	39635	9.63	7	Cell membrane	NA	Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Leukotriene receptors	PE1	13
+NX_Q9NS82	Asc-type amino acid transporter 1	523	56798	8.51	9	Membrane;Nucleoplasm;Nucleolus	NA	Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily.	Amino acid transport across the plasma membrane;Basigin interactions	PE1	19
+NX_Q9NS84	Carbohydrate sulfotransferase 7	486	54266	9.72	1	Nucleoplasm;Golgi apparatus membrane;Cytoplasmic vesicle	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.	NA	Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Chondroitin sulfate biosynthesis	PE1	X
+NX_Q9NS85	Carbonic anhydrase-related protein 10	328	37563	8.22	0	Cytoplasmic vesicle	NA	Does not have a catalytic activity.	NA	Belongs to the alpha-carbonic anhydrase family.	NA	PE1	17
+NX_Q9NS86	LanC-like protein 2	450	50854	7.18	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.	Myristoylated. Essential for membrane association.	Belongs to the LanC-like protein family.	NA	PE1	7
+NX_Q9NS87	Kinesin-like protein KIF15	1388	160160	5.75	0	Cytoplasm;Spindle	NA	Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.	MHC class II antigen presentation;Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	3
+NX_Q9NS91	E3 ubiquitin-protein ligase RAD18	495	56223	7.51	0	Nucleoplasm;Centrosome;Nucleus	NA	E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.	NA	Belongs to the RAD18 family.	Protein modification; protein ubiquitination.;Recognition of DNA damage by PCNA-containing replication complex;E3 ubiquitin ligases ubiquitinate target proteins	PE1	3
+NX_Q9NS93	Transmembrane 7 superfamily member 3	570	64166	6.56	7	Nucleoplasm;Cytosol;Cell membrane	NA	Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).	NA	NA	NA	PE1	12
+NX_Q9NS98	Semaphorin-3G	782	86701	7.97	0	Secreted	NA	Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).	NA	Belongs to the semaphorin family.	Axon guidance	PE1	3
+NX_Q9NSA0	Solute carrier family 22 member 11	550	59972	8.96	12	Cell membrane	NA	Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.	N-glycosylated. Contains several complex-type N-glycans.	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Organic anion transport	PE1	11
+NX_Q9NSA1	Fibroblast growth factor 21	209	22300	5.01	0	Secreted	NA	Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.	NA	Belongs to the heparin-binding growth factors family.	MAPK signaling pathway;Regulation of actin cytoskeleton;Pathways in cancer;Melanoma;Cellular hexose transport;Assembly of active LPL and LIPC lipase complexes	PE1	19
+NX_Q9NSA2	Potassium voltage-gated channel subfamily D member 1	647	71330	8.79	6	Membrane;Nucleoplasm;Dendrite	NA	Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.	NA	Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily.	Voltage gated Potassium channels;Phase 1 - inactivation of fast Na+ channels	PE1	X
+NX_Q9NSA3	Beta-catenin-interacting protein 1	81	9170	5.33	0	Cytoplasm;Mitochondrion;Cell membrane;Cell junction;Nucleus	NA	Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.	NA	Belongs to the CTNNBIP1 family.	Wnt signaling pathway;Deactivation of the beta-catenin transactivating complex	PE1	1
+NX_Q9NSB2	Keratin, type II cuticular Hb4	600	64842	7.74	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q9NSB4	Keratin, type II cuticular Hb2	513	56653	6.4	0	NA	NA	NA	NA	Belongs to the intermediate filament family.	Formation of the cornified envelope;Keratinization	PE1	12
+NX_Q9NSB8	Homer protein homolog 2	354	40627	6.03	0	Cytoplasm;Postsynaptic density;Synapse;Stereocilium;Cytosol	Deafness, autosomal dominant, 68	Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).	NA	Belongs to the Homer family.	Glutamatergic synapse;Neurexins and neuroligins	PE1	15
+NX_Q9NSC2	Sal-like protein 1	1324	140405	6.57	0	Nucleus speckle;Nucleolus;Nucleoplasm;Cytosol;Nucleus	Townes-Brocks syndrome 1	Transcriptional repressor involved in organogenesis.	NA	Belongs to the sal C2H2-type zinc-finger protein family.	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	PE1	16
+NX_Q9NSC5	Homer protein homolog 3	361	39836	5.39	0	Cytoplasm;Cell membrane;Postsynaptic density;Synapse;Cytosol	NA	Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).	NA	Belongs to the Homer family.	Glutamatergic synapse;Neurexins and neuroligins	PE1	19
+NX_Q9NSC7	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	600	68564	9.93	1	Golgi apparatus;Nucleoplasm;Golgi apparatus membrane	NA	NA	NA	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;Sialic acid metabolism	PE1	17
+NX_Q9NSD4	Zinc finger protein 275	429	48443	9.33	0	Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	X
+NX_Q9NSD5	Sodium- and chloride-dependent GABA transporter 2	602	68009	7.36	12	Mitochondrion;Cell membrane;Nucleolus;Nucleoplasm;Cytosol	NA	Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.	GABAergic synapse;Na+/Cl- dependent neurotransmitter transporters;Reuptake of GABA	PE1	12
+NX_Q9NSD7	Relaxin-3 receptor 1	469	51124	9.07	7	Cell membrane	NA	Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Relaxin receptors	PE1	5
+NX_Q9NSD9	Phenylalanine--tRNA ligase beta subunit	589	66116	6.39	0	Nucleoplasm;Cytosol;Cytoplasm	Rajab interstitial lung disease with brain calcifications	NA	NA	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation	PE1	2
+NX_Q9NSE2	Cytokine-inducible SH2-containing protein	258	28663	6.52	0	Cytoskeleton	NA	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).	Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa).	NA	Protein modification; protein ubiquitination.;Jak-STAT signaling pathway;Interleukin-7 signaling;Growth hormone receptor signaling;Neddylation	PE1	3
+NX_Q9NSE4	Isoleucine--tRNA ligase, mitochondrial	1012	113792	6.78	0	Mitochondrion matrix;Mitochondrion	Cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia	NA	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	1
+NX_Q9NSG2	Uncharacterized protein C1orf112	853	96554	5.64	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	1
+NX_Q9NSI2	Protein FAM207A	230	25456	11.07	0	Golgi apparatus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the FAM207 family.	NA	PE1	21
+NX_Q9NSI5	Immunoglobulin superfamily member 5	407	44593	8.14	1	Apical cell membrane;Focal adhesion;Tight junction	NA	Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity).	NA	Belongs to the immunoglobulin superfamily.	Tight junction;Epithelial cell signaling in Helicobacter pylori infection	PE2	21
+NX_Q9NSI6	Bromodomain and WD repeat-containing protein 1	2320	262936	8.73	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.	NA	NA	Interleukin-7 signaling;Chromatin modifying enzymes	PE1	21
+NX_Q9NSI8	SAM domain-containing protein SAMSN-1	373	41708	5.28	0	Cytoplasm;Cell membrane;Nucleoplasm;Ruffle;Nucleus	NA	Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).	NA	NA	NA	PE1	21
+NX_Q9NSJ1	Putative zinc finger protein 355P	428	49689	8.9	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE5	21
+NX_Q9NSK0	Kinesin light chain 4	619	68640	5.82	0	Cytosol;Mitochondrion;Cytoskeleton	NA	Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).	NA	Belongs to the kinesin light chain family.	Salmonella infection;MHC class II antigen presentation;Kinesins;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic	PE1	6
+NX_Q9NSK7	Protein C19orf12	152	16286	6.83	1	Mitochondrion membrane;Endoplasmic reticulum;Cytosol;Mitochondrion	Neurodegeneration with brain iron accumulation 4;Spastic paraplegia 43, autosomal recessive	NA	NA	NA	NA	PE1	19
+NX_Q9NSN8	Gamma-1-syntrophin	517	57969	6.24	0	Nucleus;Cytoskeleton	NA	Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.	NA	Belongs to the syntrophin family.	NA	PE1	8
+NX_Q9NSP4	Centromere protein M	180	19737	6.7	0	Nucleus;Cytosol;Cytoplasm;Kinetochore	NA	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.	NA	NA	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Deposition of new CENPA-containing nucleosomes at the centromere;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	22
+NX_Q9NSQ0	Putative ribosomal RNA-processing protein 7 homolog B	103	12575	9.73	0	NA	NA	NA	NA	Belongs to the RRP7 family.	NA	PE5	22
+NX_Q9NST1	1-acylglycerol-3-phosphate O-acyltransferase PNPLA3	481	52865	6.27	1	Mitochondrion;Lipid droplet;Nucleolus;Membrane;Cytosol	Non-alcoholic fatty liver disease 1	Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221).	NA	NA	Phospholipid metabolism.;Glycerolipid metabolism.;Glycerolipid metabolism;Metabolic pathways;Acyl chain remodeling of DAG and TAG	PE1	22
+NX_Q9NSU2	Three-prime repair exonuclease 1	314	33212	8.12	0	Cytosol;Endoplasmic reticulum membrane;Nucleus	Systemic lupus erythematosus;Aicardi-Goutieres syndrome 1;Vasculopathy, retinal, with cerebral leukodystrophy;Chilblain lupus 1	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.	Ubiquitinated, but not targeted to proteasomal degradation. Ubiquitination may be important for interaction with UBQLN1.	Belongs to the exonuclease superfamily. TREX family.	Cytosolic DNA-sensing pathway;IRF3-mediated induction of type I IFN;Regulation by TREX1	PE1	3
+NX_Q9NSV4	Protein diaphanous homolog 3	1193	136926	6.64	0	Cytoplasm;Nucleus;Cytoskeleton;Cell membrane	Auditory neuropathy, autosomal dominant, 1	Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity.	Ubiquitinated.	Belongs to the formin homology family. Diaphanous subfamily.	Regulation of actin cytoskeleton;RHO GTPases Activate Formins	PE1	13
+NX_Q9NSY0	Nuclear receptor-binding protein 2	501	57803	6.05	0	Cytoplasm;Cytosol	NA	May regulate apoptosis of neural progenitor cells during their differentiation.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	8
+NX_Q9NSY1	BMP-2-inducible protein kinase	1161	129172	6.05	0	Nucleus speckle;Nucleus	NA	May be involved in osteoblast differentiation.	Autophosphorylated.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	4
+NX_Q9NSY2	StAR-related lipid transfer protein 5	213	23794	6.22	0	Cytoplasmic vesicle;Cytosol	NA	May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).	NA	NA	Recycling of bile acids and salts	PE1	15
+NX_Q9NT22	EMILIN-3	766	82647	7.84	0	Extracellular matrix	NA	NA	NA	NA	Molecules associated with elastic fibres	PE1	20
+NX_Q9NT62	Ubiquitin-like-conjugating enzyme ATG3	314	35864	4.66	0	Cytoplasm;Cytosol;Cell membrane	NA	E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.	Conjugated to ATG12 at Lys-243. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy.;Cleaved by CASP8 upon death ligand binding such as tumor necrosis factor-alpha. CASP8 cleavage blocks survival-related autophagy and favors apoptosis.	Belongs to the ATG3 family.	Regulation of autophagy;Macroautophagy	PE1	3
+NX_Q9NT68	Teneurin-2	2774	307787	6.23	1	Golgi apparatus;Dendritic spine;Cell membrane;Postsynaptic cell membrane;Synaptosome;Growth cone;Nucleolus;Endoplasmic reticulum;Filopodium;Synapse;PML body	NA	Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion.;Ten-2 intracellular domain: Induces gene transcription inhibition.;Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer.	Ten-2, soluble form: Derives from the membrane form by proteolytic processing.;Ten-2 intracellular domain: Derives from the plasma membrane form by proteolytic cleavage and translocates to the nucleus. Homophilic binding of the C-terminal extracellular domain stimulates its proteolytic cleavage and release in the cytoplasmic. Is subjected to rapid degradation by the proteasome pathway (By similarity).	Belongs to the tenascin family. Teneurin subfamily.	NA	PE1	5
+NX_Q9NT99	Leucine-rich repeat-containing protein 4B	713	76434	6.8	1	Membrane;Presynaptic cell membrane	NA	Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).	N-glycosylated. O-glycosylated; contains sialic acid.	NA	Receptor-type tyrosine-protein phosphatases	PE1	19
+NX_Q9NTG1	Polycystic kidney disease and receptor for egg jelly-related protein	2253	255449	9.26	11	Membrane	NA	May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm.	NA	Belongs to the polycystin family.	NA	PE2	22
+NX_Q9NTG7	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	399	43573	8.98	0	Mitochondrion matrix	NA	NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity).	Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.	Belongs to the sirtuin family. Class I subfamily.	Transcriptional activation of mitochondrial biogenesis;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Regulation of FOXO transcriptional activity by acetylation	PE1	11
+NX_Q9NTI2	Phospholipid-transporting ATPase IB	1188	133599	8.41	10	Golgi apparatus;Cell membrane;Photoreceptor outer segment;Membrane;Nucleoplasm;Endosome	Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 4	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases	PE1	13
+NX_Q9NTI5	Sister chromatid cohesion protein PDS5 homolog B	1447	164667	8.67	0	Nucleoplasm;Nucleus	NA	Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.	NA	Belongs to the PDS5 family.	Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion	PE1	13
+NX_Q9NTI7	PAK4-inhibitor INKA2	297	32759	8.92	0	Nucleoplasm;Nucleus	NA	Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.	NA	Belongs to the INKA family.	NA	PE1	1
+NX_Q9NTJ3	Structural maintenance of chromosomes protein 4	1288	147182	6.37	0	Cytoplasm;Nucleus speckle;Chromosome;Cytosol;Nucleus	NA	Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.	NA	Belongs to the SMC family. SMC4 subfamily.	Condensation of Prophase Chromosomes;Condensation of Prometaphase Chromosomes	PE1	3
+NX_Q9NTJ4	Alpha-mannosidase 2C1	1040	115835	6.1	0	Cytoplasm;Nucleoplasm	NA	Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm.	NA	Belongs to the glycosyl hydrolase 38 family.	Other glycan degradation;Lysosomal oligosaccharide catabolism	PE1	15
+NX_Q9NTJ5	Phosphatidylinositide phosphatase SAC1	587	66967	6.66	3	Golgi apparatus;Nucleoplasm;Endoplasmic reticulum membrane	NA	Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621). Has low activity towards PtdIns(3,5)P2 (By similarity).	NA	NA	Synthesis of PIPs at the ER membrane;Synthesis of PIPs at the Golgi membrane	PE1	3
+NX_Q9NTK1	Protein DEPP1	212	23406	10.68	0	Cytoplasmic vesicle;Cytoplasm;Mitochondrion;Peroxisome	NA	Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.	NA	NA	NA	PE1	10
+NX_Q9NTK5	Obg-like ATPase 1	396	44744	7.64	0	Nucleolus;Cytoplasm;Cytosol;Nucleus	NA	Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.	NA	Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.	Platelet degranulation	PE1	2
+NX_Q9NTM9	Copper homeostasis protein cutC homolog	273	29341	8.47	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.	NA	Belongs to the CutC family.	Ion transport by P-type ATPases	PE1	10
+NX_Q9NTN3	UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter	355	39240	9.06	8	Cytoplasm;Endoplasmic reticulum membrane	Schneckenbecken dysplasia	Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen (PubMed:11322953, PubMed:17952091). Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity).	NA	Belongs to the TPT transporter family. SLC35D subfamily.	Transport of nucleotide sugars;Formation of the active cofactor, UDP-glucuronate;Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)	PE1	1
+NX_Q9NTN9	Semaphorin-4G	838	91497	8.1	1	Cytoplasmic vesicle;Cell membrane;Lipid droplet	NA	Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).	NA	Belongs to the semaphorin family.	Axon guidance	PE1	10
+NX_Q9NTQ9	Gap junction beta-4 protein	266	30419	8.4	4	Cell junction;Gap junction;Cell membrane	Erythrokeratodermia variabilis et progressiva 2	Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity).	NA	Belongs to the connexin family. Beta-type (group I) subfamily.	Gap junction assembly	PE1	1
+NX_Q9NTU4	Cation channel sperm-associated protein subunit zeta	200	22839	5.8	0	Cytoplasm;Nucleoplasm;Flagellum membrane	NA	Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.	NA	NA	NA	PE1	11
+NX_Q9NTU7	Cerebellin-4	201	21808	8.85	0	Secreted;Synapse	NA	May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).	NA	NA	NA	PE1	20
+NX_Q9NTW7	Zinc finger protein 64	645	72217	8.8	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	20
+NX_Q9NTX5	Ethylmalonyl-CoA decarboxylase	307	33698	8.32	0	Cytoplasmic vesicle;Cytosol	NA	Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).	NA	Belongs to the enoyl-CoA hydratase/isomerase family.	NA	PE1	6
+NX_Q9NTX7	E3 ubiquitin-protein ligase RNF146	359	38950	5.17	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.	Ubiquitinated; autoubiquitinated. Polyubiquitinated in the presence of UBE2D1, UBE2D2 and UBE2D3. Multimonoubiquitinated in the presence of UBE2E1. Not ubiquitinated in the presence of UBE2H, CDC34, UBE2L3, UBE2L6, nor UBE2C. In the absence of PAR, autoubiquitination occurs on Lys-85, Lys-95 and Lys-176 via 'Lys-11' and 'Lys-48' ubiquitin linkages. In the presence of PAR, Lys-131 and Lys-176 are ubiquitinated via 'Lys-6', 'Lys-33' and 'Lys-48' ubiquitin linkages. Autoubiquitination is enhanced upon PAR-binding.	NA	Protein modification; protein ubiquitination.;Degradation of AXIN;TCF dependent signaling in response to WNT;Ub-specific processing proteases;Regulation of PTEN stability and activity	PE1	6
+NX_Q9NTX9	Protein FAM217B	383	42052	9.76	0	Nucleoplasm	NA	NA	NA	Belongs to the FAM217 family.	NA	PE1	20
+NX_Q9NTZ6	RNA-binding protein 12	932	97395	8.74	0	Nucleoplasm;Nucleus	Schizophrenia 19	NA	NA	NA	NA	PE1	20
+NX_Q9NU02	Ankyrin repeat and EF-hand domain-containing protein 1	776	86664	8.51	0	Cytosol;Nucleolus;Cell membrane	NA	NA	NA	NA	NA	PE1	20
+NX_Q9NU19	TBC1 domain family member 22B	505	59081	6.94	0	Nucleoplasm;Cytosol	NA	May act as a GTPase-activating protein for Rab family protein(s).	NA	NA	NA	PE1	6
+NX_Q9NU22	Midasin	5596	632820	5.46	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Cytoskeleton	NA	Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity).	NA	Belongs to the midasin family.	NA	PE1	6
+NX_Q9NU23	LYR motif-containing protein 2	88	10449	10.46	0	Cytoplasm;Cytosol	NA	NA	NA	Belongs to the complex I LYR family.	NA	PE1	6
+NX_Q9NU39	Forkhead box protein D4-like 1	408	43610	9.36	0	Nucleus	NA	NA	NA	NA	NA	PE2	2
+NX_Q9NU53	Glycoprotein integral membrane protein 1	330	36840	4.81	1	Membrane;Nucleolus;Cell membrane	NA	NA	NA	NA	NA	PE1	6
+NX_Q9NU63	Zinc finger protein 57 homolog	452	51919	9.34	0	Nucleus	Diabetes mellitus, transient neonatal, 1	Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:18622393, PubMed:30602440). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family. ZFP57 subfamily.	NA	PE1	6
+NX_Q9NUA8	Zinc finger and BTB domain-containing protein 40	1239	138118	6.11	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_Q9NUB1	Acetyl-coenzyme A synthetase 2-like, mitochondrial	689	74857	6.66	0	Mitochondrion matrix	NA	Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity).	Reversibly acetylated on Lys-642 (PubMed:16788062). The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylase SIRT3.	Belongs to the ATP-dependent AMP-binding enzyme family.	Glycolysis / Gluconeogenesis;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Ethanol oxidation	PE1	20
+NX_Q9NUB4	Uncharacterized protein C20orf141	165	17394	7.8	1	Membrane	NA	NA	NA	NA	NA	PE2	20
+NX_Q9NUC0	SERTA domain-containing protein 4	356	39348	6.27	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	1
+NX_Q9NUD5	Zinc finger CCHC domain-containing protein 3	403	43547	8.86	0	Cytoplasm;Cytoplasmic vesicle	NA	Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5 (PubMed:30193849).	NA	NA	NA	PE1	20
+NX_Q9NUD7	Uncharacterized protein C20orf96	363	42859	8.81	0	Centriolar satellite	NA	NA	NA	NA	NA	PE1	20
+NX_Q9NUD9	GPI mannosyltransferase 2	493	55713	8.2	10	Endoplasmic reticulum;Cytosol;Endoplasmic reticulum membrane	Hyperphosphatasia with mental retardation syndrome 1	Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly.	Not N-glycosylated.	Belongs to the PIGV family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	1
+NX_Q9NUE0	Palmitoyltransferase ZDHHC18	388	42031	9.33	4	Membrane;Cytoskeleton	NA	Has palmitoyltransferase activity towards HRAS and LCK.	NA	Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.	NA	PE1	1
+NX_Q9NUG4	Cerebral cavernous malformations 2 protein-like	571	62179	5.62	0	Nucleoplasm	NA	NA	NA	Belongs to the CCM2 family.	NA	PE1	20
+NX_Q9NUG6	p53 and DNA damage-regulated protein 1	133	15511	5.81	0	Cytoplasm;Cytoskeleton	NA	May play a role in chaperone-mediated protein folding.	NA	Belongs to the prefoldin subunit beta family.	NA	PE1	20
+NX_Q9NUH8	Transmembrane protein 14B	114	12078	9.57	4	Membrane	NA	Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.	NA	Belongs to the TMEM14 family.	NA	PE1	6
+NX_Q9NUI1	Peroxisomal 2,4-dienoyl-CoA reductase	292	30778	9.38	0	Peroxisome	NA	Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.	Peroxisome;Beta-oxidation of very long chain fatty acids;Peroxisomal protein import	PE1	16
+NX_Q9NUJ1	Mycophenolic acid acyl-glucuronide esterase, mitochondrial	306	33933	8.81	0	Mitochondrion	NA	Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.	NA	Belongs to the AB hydrolase superfamily.	Glucuronidation	PE1	3
+NX_Q9NUJ3	T-complex protein 11-like protein 1	509	57035	5.41	0	Cytosol	NA	NA	NA	Belongs to the TCP11 family.	NA	PE1	11
+NX_Q9NUJ7	PI-PLC X domain-containing protein 1	323	36668	6.11	0	Cytoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	X
+NX_Q9NUK0	Muscleblind-like protein 3	354	38532	9.13	0	Golgi apparatus;Cytoplasmic vesicle;Cytoplasm;Nucleus	NA	Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.	NA	Belongs to the muscleblind family.	NA	PE1	X
+NX_Q9NUL3	Double-stranded RNA-binding protein Staufen homolog 2	570	62608	9.62	0	Cytoplasm;Nucleolus;Nucleoplasm;Endoplasmic reticulum;Cytosol;Nucleus	NA	RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity).	NA	NA	NA	PE1	8
+NX_Q9NUL5	Shiftless antiviral inhibitor of ribosomal frameshifting protein	291	33110	6.86	0	Cytoplasm;Nucleoplasm;P-body;Cytosol;Nucleus	NA	Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (PubMed:30682371). Regulates HIV1 GAG-POL expression by inhibiting -1PRF (PubMed:30682371). Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137, PubMed:27974568). Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA (PubMed:27974568).;Does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes.	NA	Belongs to the SHFL family.	NA	PE1	19
+NX_Q9NUL7	Probable ATP-dependent RNA helicase DDX28	540	59581	10.43	0	Mitochondrion;Mitochondrion matrix;Nucleolus;Mitochondrion nucleoid;Cytosol;Nucleus	NA	Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955).	NA	Belongs to the DEAD box helicase family.	NA	PE1	16
+NX_Q9NUM3	Zinc transporter ZIP9	307	32251	6.21	8	Membrane;Endoplasmic reticulum	NA	May act as a zinc-influx transporter.	NA	Belongs to the ZIP transporter (TC 2.A.5) family.	NA	PE1	14
+NX_Q9NUM4	Transmembrane protein 106B	274	31127	6.52	1	Lysosome membrane;Membrane;Endosome;Lysosome;Late endosome membrane	Ubiquitin-positive frontotemporal dementia;Leukodystrophy, hypomyelinating, 16;Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.	NA	Belongs to the TMEM106 family.	NA	PE1	7
+NX_Q9NUN5	Probable lysosomal cobalamin transporter	540	61389	7.89	9	Lysosome membrane	Methylmalonic aciduria and homocystinuria, cblF type	(Microbial infection) Isoform 3: May play a role in the assembly of hepatitis delta virus (HDV).;Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.	N-glycosylated.	Belongs to the LIMR family. LMBRD1 subfamily.	Vitamin digestion and absorption;Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF	PE1	6
+NX_Q9NUN7	Alkaline ceramidase 3	267	31552	8.87	7	Endoplasmic reticulum membrane;Golgi apparatus membrane	Leukodystrophy, progressive, early childhood-onset	Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:20068046, PubMed:26792856, PubMed:20207939, PubMed:11356846, PubMed:30575723). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20068046). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (PubMed:20207939). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity).	NA	Belongs to the alkaline ceramidase family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Sphingolipid de novo biosynthesis	PE1	11
+NX_Q9NUP1	Biogenesis of lysosome-related organelles complex 1 subunit 4	217	23351	4.9	0	Cytoplasm;Cytosol;Cytoplasmic vesicle	NA	Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.	NA	Belongs to the BLOC1S4 family.	Golgi Associated Vesicle Biogenesis	PE1	4
+NX_Q9NUP7	tRNA:m(4)X modification enzyme TRM13 homolog	481	54247	8.36	0	Nucleoplasm;Cytosol;Nucleus;Cell membrane	NA	TRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).	NA	Belongs to the methyltransferase TRM13 family.	tRNA modification in the nucleus and cytosol	PE1	1
+NX_Q9NUP9	Protein lin-7 homolog C	197	21834	8.52	0	Cell membrane;Basolateral cell membrane;Cell junction;Tight junction;Postsynaptic density membrane	NA	Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.	NA	Belongs to the lin-7 family.	Dopamine Neurotransmitter Release Cycle;Neurexins and neuroligins;Assembly and cell surface presentation of NMDA receptors	PE1	11
+NX_Q9NUQ2	1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon	364	42072	9.18	3	Endoplasmic reticulum membrane;Mitochondrion;Nucleus envelope	NA	Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed:21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed:21173190).	NA	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.;Synthesis of PA	PE1	8
+NX_Q9NUQ3	Gamma-taxilin	528	60586	7.23	0	Cytosol;Nucleus membrane	NA	May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.	NA	Belongs to the taxilin family.	NA	PE1	X
+NX_Q9NUQ6	SPATS2-like protein	558	61729	9.67	0	Cytoplasm;Nucleolus;Cytosol;Nucleus;Cytoskeleton	NA	NA	NA	Belongs to the SPATS2 family.	NA	PE1	2
+NX_Q9NUQ7	Ufm1-specific protease 2	469	53261	6.52	0	Cytoplasm;Endoplasmic reticulum;Nucleoplasm;Cytosol;Nucleus	Spondyloepimetaphyseal dysplasia, Di Rocco type;Beukes familial hip dysplasia	Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.	NA	Belongs to the peptidase C78 family.	NA	PE1	4
+NX_Q9NUQ8	ATP-binding cassette sub-family F member 3	709	79745	5.95	0	Cytosol;Nucleolus	NA	Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.	NA	Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.	NA	PE1	3
+NX_Q9NUQ9	Protein FAM49B	324	36748	5.76	0	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the FAM49 family.	Platelet degranulation	PE1	8
+NX_Q9NUR3	Transmembrane protein 74B	256	27551	6.97	2	Membrane;Golgi apparatus;Nucleoplasm	NA	NA	NA	Belongs to the TMEM74 family.	NA	PE1	20
+NX_Q9NUS5	AP-5 complex subunit sigma-1	200	22522	6.38	0	Nucleoplasm;Cytosol;Lysosome membrane;Late endosome membrane	NA	As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair.	NA	NA	NA	PE1	20
+NX_Q9NUT2	ATP-binding cassette sub-family B member 8, mitochondrial	735	79989	9.21	5	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	NA	NA	Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.	ABC transporters;Mitochondrial ABC transporters	PE1	7
+NX_Q9NUU6	Inactive ubiquitin thioesterase OTULINL	356	42196	9.36	0	Cytoplasm;Endoplasmic reticulum membrane;Nucleolus;Nucleus envelope;Cytosol	NA	Lacks deubiquitinase activity.	NA	Belongs to the peptidase C65 family. Otulin subfamily.	NA	PE1	5
+NX_Q9NUU7	ATP-dependent RNA helicase DDX19A	478	53975	6.2	0	Cytoplasm;Nucleus membrane;Nuclear pore complex	NA	ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).	NA	Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.	NA	PE1	16
+NX_Q9NUV7	Serine palmitoyltransferase 3	552	62049	8.9	1	Endoplasmic reticulum membrane;Cytoskeleton	NA	Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. SPT complexes containing SPTLC3 generate shorter chain sphingoid bases compared to complexes containing SPTLC2. The SPTLC1-SPTLC3-SPTSSA isozyme uses C12-CoA, C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. On the other hand, the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference.	NA	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Sphingolipid de novo biosynthesis	PE1	20
+NX_Q9NUV9	GTPase IMAP family member 4	329	37534	7.66	0	Cytosol	NA	During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP.	Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation.	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.	NA	PE1	7
+NX_Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	608	68420	7.34	0	Nucleoplasm;Cytoplasm;Nucleus;Cell membrane	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1	DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.	Phosphorylated on serine and/or threonine residues, but not on tyrosine residues.	Belongs to the tyrosyl-DNA phosphodiesterase family.	Nonhomologous End-Joining (NHEJ)	PE1	14
+NX_Q9NUX5	Protection of telomeres protein 1	634	71442	6.26	0	Nucleoplasm;Telomere;Nucleus	Glioma 9;Melanoma, cutaneous malignant 10	Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.	NA	Belongs to the telombin family.	Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine	PE1	7
+NX_Q9NUY8	TBC1 domain family member 23	699	78322	5.23	0	trans-Golgi network;Cytoplasmic vesicle;Golgi apparatus	Pontocerebellar hypoplasia 11	Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity).	NA	NA	NA	PE1	3
+NX_Q9NUZ1	Acyl-coenzyme A oxidase-like protein	547	61795	8.78	0	Cytosol;Nucleolus	NA	NA	NA	Belongs to the acyl-CoA oxidase family.	Beta-oxidation of pristanoyl-CoA	PE2	2
+NX_Q9NV06	DDB1- and CUL4-associated factor 13	445	51402	9.3	0	Cell junction;Nucleolus;Nucleoplasm;Centrosome;Cytosol	NA	Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	NA	Belongs to the WD repeat DCAF13/WDSOF1 family.	Protein modification; protein ubiquitination.;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Neddylation	PE1	8
+NX_Q9NV12	Transmembrane protein 140	185	20419	7.62	4	Membrane	NA	NA	NA	NA	NA	PE1	7
+NX_Q9NV23	S-acyl fatty acid synthase thioesterase, medium chain	265	29931	5.81	0	Cytosol	NA	Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16).	NA	Belongs to the thioesterase family.	Fatty acid biosynthesis;Metabolic pathways;Fatty acyl-CoA biosynthesis	PE1	10
+NX_Q9NV29	Transmembrane protein 100	134	14386	9.55	2	Cell membrane;Perikaryon;Membrane;Nucleoplasm;Endoplasmic reticulum;Perinuclear region	NA	Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.	NA	NA	NA	PE1	17
+NX_Q9NV31	U3 small nucleolar ribonucleoprotein protein IMP3	184	21850	9.54	0	Nucleoplasm;Nucleolus;Nucleus	NA	Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.	NA	Belongs to the universal ribosomal protein uS4 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	15
+NX_Q9NV35	Nucleotide triphosphate diphosphatase NUDT15	164	18609	5.75	0	Nucleoplasm	NA	May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956).	NA	Belongs to the Nudix hydrolase family.	Phosphate bond hydrolysis by NUDT proteins	PE1	13
+NX_Q9NV39	Proline-rich protein 34	138	14718	12.42	0	NA	NA	NA	NA	NA	NA	PE1	22
+NX_Q9NV44	Putative uncharacterized protein encoded by LINC00846	126	13706	7.06	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_Q9NV56	MRG/MORF4L-binding protein	204	22417	5.57	0	Nucleoplasm;Nucleus	NA	Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.	NA	Belongs to the EAF7 family.	HATs acetylate histones	PE1	20
+NX_Q9NV58	E3 ubiquitin-protein ligase RNF19A	838	90696	6.59	2	Membrane;Centrosome	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.	NA	Belongs to the RBR family. RNF19 subfamily.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	8
+NX_Q9NV64	Transmembrane protein 39A	488	55667	9.01	8	Membrane;Cytoplasmic vesicle;Nucleoplasm	NA	NA	NA	Belongs to the TMEM39 family.	NA	PE1	3
+NX_Q9NV66	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1	732	83702	6.42	0	NA	NA	Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).	NA	Belongs to the TYW1 family.	tRNA modification; wybutosine-tRNA(Phe) biosynthesis.;Synthesis of wybutosine at G37 of tRNA(Phe)	PE1	7
+NX_Q9NV70	Exocyst complex component 1	894	101982	6.17	0	Cytoplasm;Cell membrane;Midbody ring;Cytosol;Perinuclear region;Cytoskeleton	NA	(Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation.;Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	NA	Belongs to the SEC3 family.	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium	PE1	4
+NX_Q9NV72	Zinc finger protein 701	531	60903	9.41	0	Nucleoplasm;Centriolar satellite;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9NV79	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2	361	41072	5.8	0	Cytoplasm;Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.	NA	PE1	20
+NX_Q9NV88	Integrator complex subunit 9	658	73814	5.9	0	Nucleoplasm;Nucleus	NA	Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).	NA	Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.	RNA polymerase II transcribes snRNA genes	PE1	8
+NX_Q9NV92	NEDD4 family-interacting protein 2	336	36390	4.99	3	Cytoplasmic vesicle;Endosome membrane;Multivesicular body membrane;Golgi apparatus membrane	NA	Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity).	Ubiquitinated by NEDD4 and ITCH. Also ubiquitinated by NEDD4L. Ubiquitination by NEDD4 or NEDD4L does not affect turnover (By similarity).;Undergoes transient tyrosine-phosphorylation following EGF stimulation, most probably catalyzed by SRC. Phosphorylation on Tyr-151, Tyr-171 and Tyr-177 are dependent on the phosphorylation on Tyr-167. Also phosphorylated by LYN and FYN.;NDFIP2 is phosphorylated by SRC (Phosphotyrosine:PTM-0255);NDFIP2 is phosphorylated by LYN (Phosphotyrosine:PTM-0255)	NA	NA	PE1	13
+NX_Q9NV96	Cell cycle control protein 50A	361	40684	8.81	2	Golgi apparatus;Mitochondrion;Cell membrane;Membrane;Secretory vesicle membrane;Apical cell membrane	NA	Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations.	N-glycosylated. Contains high mannose-type oligosaccharides (By similarity).	Belongs to the CDC50/LEM3 family.	Neutrophil degranulation	PE1	6
+NX_Q9NVA1	Ubiquinol-cytochrome-c reductase complex assembly factor 1	299	34600	9.1	0	Cell membrane;Nucleoplasm;Cytoplasmic vesicle;Mitochondrion inner membrane;Cytoskeleton	NA	Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability.	NA	Belongs to the CBP3 family.	NA	PE1	20
+NX_Q9NVA2	Septin-11	429	49398	6.36	0	Cytoplasm;Dendritic spine;Cell membrane;Synapse;Axon;Cytoskeleton	NA	Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	NA	PE1	4
+NX_Q9NVA4	Transmembrane protein 184C	438	50142	5.85	7	Membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Possible tumor suppressor which may play a role in cell growth.	NA	Belongs to the TMEM184 family.	NA	PE1	4
+NX_Q9NVC3	Putative sodium-coupled neutral amino acid transporter 7	462	49966	4.98	11	Cell membrane;Membrane;Nucleoplasm;Endosome;Cytosol	NA	Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.	NA	Belongs to the amino acid/polyamine transporter 2 family.	NA	PE1	16
+NX_Q9NVC6	Mediator of RNA polymerase II transcription subunit 17	651	72890	7.05	0	Cytosol;Nucleus speckle;Nucleus	Microcephaly, postnatal progressive, with seizures and brain atrophy	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 17 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	11
+NX_Q9NVD3	SET domain-containing protein 4	440	50416	8.53	0	Cytosol;Nucleus speckle;Nucleus	NA	NA	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family.	NA	PE1	21
+NX_Q9NVD7	Alpha-parvin	372	42244	5.69	0	Cell membrane;Focal adhesion;Cytosol;Z line;Cytoskeleton	NA	Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.	NA	Belongs to the parvin family.	Focal adhesion;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;Cell-extracellular matrix interactions	PE1	11
+NX_Q9NVE4	Coiled-coil domain-containing protein 87	849	96402	8.74	0	NA	NA	Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility.	NA	Belongs to the CCDC87 family.	NA	PE1	11
+NX_Q9NVE5	Ubiquitin carboxyl-terminal hydrolase 40	1235	140130	5.46	0	Cytoplasmic vesicle	NA	May be catalytically inactive.	NA	Belongs to the peptidase C19 family.	NA	PE1	2
+NX_Q9NVE7	Pantothenate kinase 4	773	85991	5.88	0	Cytoplasm;Cytosol	NA	Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity). The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'-phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068).	NA	In the N-terminal section; belongs to the type II pantothenate kinase family.;In the C-terminal section; belongs to the damage-control phosphatase family. Phosphopantetheine phosphatase II subfamily.	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.;Pantothenate and CoA biosynthesis;Metabolic pathways;Coenzyme A biosynthesis	PE1	1
+NX_Q9NVF7	F-box only protein 28	368	41149	9.59	0	Nucleoplasm;Focal adhesion;Kinetochore	NA	Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.	NA	NA	NA	PE1	1
+NX_Q9NVF9	Ethanolamine kinase 2	386	44781	6.94	0	NA	NA	Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity).	NA	Belongs to the choline/ethanolamine kinase family.	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PE	PE1	1
+NX_Q9NVG8	TBC1 domain family member 13	400	46554	5.11	0	Membrane;Cytoplasm;Nucleolus	NA	Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.	NA	NA	TBC/RABGAPs	PE1	9
+NX_Q9NVH0	Exonuclease 3'-5' domain-containing protein 2	621	70353	8.63	1	Mitochondrion outer membrane;Mitochondrion;Mitochondrion matrix;Chromosome;Nucleus;Cytoskeleton	NA	Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466).	NA	Belongs to the EXD2 family.	NA	PE1	14
+NX_Q9NVH1	DnaJ homolog subfamily C member 11	559	63278	8.54	0	Mitochondrion outer membrane;Cytosol;Mitochondrion	NA	Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.	NA	Belongs to the DNAJC11 family.	Cristae formation	PE1	1
+NX_Q9NVH2	Integrator complex subunit 7	962	106834	8.3	0	Cytoplasm;Centrosome;Nucleus;Chromosome	NA	Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267).	NA	Belongs to the Integrator subunit 7 family.	RNA polymerase II transcribes snRNA genes	PE1	1
+NX_Q9NVH6	Trimethyllysine dioxygenase, mitochondrial	421	49518	7.64	0	Mitochondrion matrix;Mitochondrion	Autism, X-linked 6	Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (PubMed:11431483, PubMed:23092983).	NA	Belongs to the gamma-BBH/TMLD family.	Amine and polyamine biosynthesis; carnitine biosynthesis.;Lysine degradation;Carnitine synthesis	PE1	X
+NX_Q9NVI1	Fanconi anemia group I protein	1328	149324	6.31	0	Nucleoplasm;Nucleus	Fanconi anemia complementation group I	Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.	Monoubiquitinated by FANCL on Lys-523 during S phase and upon genotoxic stress. Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the FANCA-FANCB-FANCC-FANCE-FANCF-FANCG-FANCM complex. Ubiquitination is required for binding to chromatin, DNA repair, and normal cell cycle progression. Monoubiquitination is stimulated by DNA-binding.;Phosphorylated in response to DNA damage by ATM and/or ATR.	NA	Fanconi anemia pathway;Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes	PE1	15
+NX_Q9NVI7	ATPase family AAA domain-containing protein 3A	634	71369	9.08	1	Mitochondrion inner membrane;Mitochondrion nucleoid	Harel-Yoon syndrome	Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis.	NA	Belongs to the AAA ATPase family.	NA	PE1	1
+NX_Q9NVJ2	ADP-ribosylation factor-like protein 8B	186	21539	8.67	0	Axon;Lysosome membrane;Synapse;Spindle;Late endosome membrane	NA	Plays a role in lysosome motility (PubMed:16537643, PubMed:25898167). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (PubMed:15331635).	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	3
+NX_Q9NVK5	FGFR1 oncogene partner 2	253	29426	5.69	0	Cytoplasm;Mitochondrion	NA	May be involved in wound healing pathway.	NA	Belongs to the SIKE family.	Signaling by FGFR1 in disease;Signaling by cytosolic FGFR1 fusion mutants	PE1	12
+NX_Q9NVL1	Protein FAM86C1	165	18454	8.51	0	NA	NA	NA	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.	NA	PE1	11
+NX_Q9NVL8	Uncharacterized protein CCDC198	296	34690	9.28	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	14
+NX_Q9NVM1	Protein eva-1 homolog B	165	18374	4.62	1	Membrane;Cytosol	NA	NA	NA	Belongs to the EVA1 family.	NA	PE1	1
+NX_Q9NVM4	Protein arginine N-methyltransferase 7	692	78459	5.33	0	Nucleolus;Nucleoplasm;Cytosol;Nucleus	Short stature, brachydactyly, intellectual developmental disability, and seizures	Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.	RMTs methylate histone arginines	PE1	16
+NX_Q9NVM6	DnaJ homolog subfamily C member 17	304	34687	8.61	0	Cytoplasm;Nucleoplasm;Nucleus	NA	May negatively affect PAX8-induced thyroglobulin/TG transcription.	NA	NA	NA	PE1	15
+NX_Q9NVM9	Integrator complex subunit 13	706	80225	6.24	0	Nucleoplasm;Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267).	NA	Belongs to the asunder family.	RNA polymerase II transcribes snRNA genes	PE1	12
+NX_Q9NVN3	Synembryn-B	520	58825	5.52	0	Cell cortex	NA	Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.	NA	Belongs to the synembryn family.	NA	PE1	12
+NX_Q9NVN8	Guanine nucleotide-binding protein-like 3-like protein	582	65573	8.68	0	Nucleoplasm;Cytosol;Nucleolus	NA	Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.	NA	Belongs to the TRAFAC class YlqF/YawG GTPase family.	Ribosome biogenesis in eukaryotes	PE1	X
+NX_Q9NVP1	ATP-dependent RNA helicase DDX18	670	75407	9.52	0	Nucleus;Nucleolus;Chromosome	NA	Probable RNA-dependent helicase.	NA	Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.	NA	PE1	2
+NX_Q9NVP2	Histone chaperone ASF1B	202	22434	4.46	0	Nucleoplasm;Nucleus	NA	Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis.	Phosphorylated by TLK1 and TLK2.	Belongs to the ASF1 family.	NA	PE1	19
+NX_Q9NVP4	Double zinc ribbon and ankyrin repeat-containing protein 1	752	82192	8.44	0	Nucleolus	NA	NA	NA	NA	NA	PE1	20
+NX_Q9NVQ4	Fas apoptotic inhibitory molecule 1	179	20215	5.55	0	Cytoplasm;Cytosol;Cell membrane	NA	Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.	NA	Belongs to the FAIM1 family.	NA	PE1	3
+NX_Q9NVR0	Kelch-like protein 11	708	80148	5.78	0	NA	NA	Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	17
+NX_Q9NVR2	Integrator complex subunit 10	710	82236	7.24	0	Nucleoplasm;Cytosol;Nucleus	NA	Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267).	NA	Belongs to the Integrator subunit 10 family.	RNA polymerase II transcribes snRNA genes	PE1	8
+NX_Q9NVR5	Protein kintoun	837	91114	5.1	0	Cytoplasm;Cytosol	Ciliary dyskinesia, primary, 10	Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.	NA	Belongs to the PIH1 family. Kintoun subfamily.	NA	PE1	14
+NX_Q9NVR7	TBCC domain-containing protein 1	557	63530	8.93	0	Spindle pole;Centrosome	NA	Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.	NA	Belongs to the TBCC family.	NA	PE1	3
+NX_Q9NVS2	39S ribosomal protein S18a, mitochondrial	196	22184	10.35	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	6
+NX_Q9NVS9	Pyridoxine-5'-phosphate oxidase	261	29988	6.61	0	Nucleoplasm;Cytosol	Pyridoxine-5'-phosphate oxidase deficiency	Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).	NA	Belongs to the pyridoxamine 5'-phosphate oxidase family.	Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.;Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.;Vitamin B6 metabolism;Metabolic pathways;Vitamins B6 activation to pyridoxal phosphate	PE1	17
+NX_Q9NVT9	Armadillo repeat-containing protein 1	282	31281	5.54	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	8
+NX_Q9NVU0	DNA-directed RNA polymerase III subunit RPC5	708	79898	6.05	0	Nucleoplasm;Nucleus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).	NA	NA	Purine metabolism;Pyrimidine metabolism;RNA polymerase;Cytosolic DNA-sensing pathway;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	16
+NX_Q9NVU7	Protein SDA1 homolog	687	79871	9.29	0	Nucleoplasm;Nucleolus	NA	Required for 60S pre-ribosomal subunits export to the cytoplasm.	NA	Belongs to the SDA1 family.	NA	PE1	4
+NX_Q9NVV0	Trimeric intracellular cation channel type B	291	32510	9.16	7	Endoplasmic reticulum membrane	Osteogenesis imperfecta 14	Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.	NA	Belongs to the TMEM38 family.	NA	PE1	9
+NX_Q9NVV2	Putative uncharacterized protein C19orf73	129	13750	12	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	19
+NX_Q9NVV4	Poly(A) RNA polymerase, mitochondrial	582	66172	9.24	0	Cytoplasm;Mitochondrion	Spastic ataxia 4, autosomal recessive	Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.	NA	Belongs to the DNA polymerase type-B-like family.	NA	PE1	10
+NX_Q9NVV5	Androgen-induced gene 1 protein	245	28222	8.49	6	Golgi apparatus;Cell membrane	NA	Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888).	NA	Belongs to the AIG1 family.	NA	PE1	6
+NX_Q9NVV9	THAP domain-containing protein 1	213	24944	8.66	0	Nucleoplasm;PML body	Dystonia 6, torsion	DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.	NA	Belongs to the THAP1 family.	NA	PE1	8
+NX_Q9NVW2	E3 ubiquitin-protein ligase RLIM	624	68549	7.2	0	Nucleoplasm;Cytosol;Nucleus	Tonne-Kalscheuer syndrome	E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.	NA	Belongs to the RNF12 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	X
+NX_Q9NVX0	HAUS augmin-like complex subunit 2	235	26933	7.74	0	Nucleoplasm;Cytosol;Spindle;Centrosome	NA	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.	NA	Belongs to the HAUS2 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	15
+NX_Q9NVX2	Notchless protein homolog 1	485	53320	6.92	0	Nucleoplasm;Nucleolus	NA	Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).	NA	Belongs to the NLE1/RSA4 family.	NA	PE1	17
+NX_Q9NVX7	Kelch repeat and BTB domain-containing protein 4	518	58144	5.42	0	Cytoplasmic vesicle;Cytoplasm;Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	11
+NX_Q9NVZ3	Adaptin ear-binding coat-associated protein 2	263	28339	8.49	0	Cytoplasm;Cell membrane;Endoplasmic reticulum;Clathrin-coated vesicle membrane;Nucleus	NA	Involved in endocytosis.	NA	Belongs to the NECAP family.	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	1
+NX_Q9NW07	Zinc finger protein 358	568	59287	6.11	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q9NW08	DNA-directed RNA polymerase III subunit RPC2	1133	127785	8.77	0	Nucleus speckle;Nucleus	Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.	NA	Belongs to the RNA polymerase beta chain family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	12
+NX_Q9NW13	RNA-binding protein 28	759	85738	9.26	0	Nucleolus	Alopecia, neurologic defects, and endocrinopathy syndrome	Nucleolar component of the spliceosomal ribonucleoprotein complexes.	NA	NA	Ribosome biogenesis in eukaryotes;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	7
+NX_Q9NW15	Anoctamin-10	660	76329	7.1	8	Cytoplasmic vesicle;Cell membrane	Spinocerebellar ataxia, autosomal recessive, 10	Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.	NA	Belongs to the anoctamin family.	Stimuli-sensing channels	PE1	3
+NX_Q9NW38	E3 ubiquitin-protein ligase FANCL	375	42905	6.02	0	Cytoplasm;Nucleus;Cytoplasmic vesicle	Fanconi anemia complementation group L	Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.	The RING-type zinc finger domain is monoubiquitinated in the presence of UBE2T and UBE2W.	NA	Protein modification; protein ubiquitination.;Fanconi anemia pathway;Ubiquitin mediated proteolysis;Fanconi Anemia Pathway	PE1	2
+NX_Q9NW61	Pleckstrin homology domain-containing family J member 1	149	17551	7.69	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	19
+NX_Q9NW64	Pre-mRNA-splicing factor RBM22	420	46896	8.83	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.	NA	Belongs to the SLT11 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	5
+NX_Q9NW68	BSD domain-containing protein 1	430	47163	4.43	0	Golgi apparatus;Cell membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q9NW75	G patch domain-containing protein 2	528	58944	9.2	0	Nucleus speckle;Nucleolus	NA	Enhances the ATPase activity of DHX15 in vitro.	NA	NA	NA	PE1	1
+NX_Q9NW81	Distal membrane-arm assembly complex protein 2	257	29267	6	0	Mitochondrion	NA	Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.	NA	Belongs to the ATP synthase subunit s family.	NA	PE1	19
+NX_Q9NW82	WD repeat-containing protein 70	654	73201	5.94	0	Cytosol;Mitochondrion	NA	NA	NA	Belongs to the WD repeat GAD-1 family.	NA	PE1	5
+NX_Q9NW97	Transmembrane protein 51	253	27759	5.4	2	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q9NWA0	Mediator of RNA polymerase II transcription subunit 9	146	16403	6.84	0	Midbody;Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 9 family.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	17
+NX_Q9NWB1	RNA binding protein fox-1 homolog 1	397	42784	6.37	0	Cytoplasm;Nucleus	NA	RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.	NA	NA	MECP2 regulates transcription factors	PE1	16
+NX_Q9NWB6	Arginine and glutamate-rich protein 1	273	33216	10.35	0	Nucleoplasm;Cytosol;Mitochondrion;Nucleus	NA	Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.	NA	Belongs to the UPF0430 family.	NA	PE1	13
+NX_Q9NWB7	Intraflagellar transport protein 57 homolog	429	49108	4.93	0	Cytosol;Nucleus speckle;Cilium basal body;Mitochondrion	Orofaciodigital syndrome 18	Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.	NA	Belongs to the IFT57 family.	Huntington's disease;Intraflagellar transport;Hedgehog 'off' state	PE1	3
+NX_Q9NWC5	Transmembrane protein 45A	275	31680	7.13	5	Endoplasmic reticulum;Cytoplasmic vesicle;Membrane	NA	NA	NA	Belongs to the TMEM45 family.	NA	PE1	3
+NX_Q9NWD8	Transmembrane protein 248	314	35052	5.91	4	Membrane;Cytoplasmic vesicle	NA	NA	NA	Belongs to the TMEM248 family.	NA	PE1	7
+NX_Q9NWD9	Protein BEX4	120	14067	5.97	0	Cytoplasm;Nucleoplasm;Spindle pole;Cytosol;Nucleus	NA	May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate to the control of cell cycle progression and genomic stability.	Ubiquitinated and degraded by the proteasome.	Belongs to the BEX family.	NA	PE1	X
+NX_Q9NWF4	Solute carrier family 52, riboflavin transporter, member 1	448	46317	5.9	11	Cell membrane	Riboflavin deficiency	(Microbial infection) May function as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).;Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:18632736, PubMed:20463145). Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145).	NA	Belongs to the riboflavin transporter family.	Vitamin B2 (riboflavin) metabolism	PE1	17
+NX_Q9NWF9	E3 ubiquitin-protein ligase RNF216	866	99406	4.83	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Gordon Holmes syndrome	Inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.;Acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production.	Auto-ubiquitinated.	NA	Protein modification; protein ubiquitination.;Negative regulators of DDX58/IFIH1 signaling	PE1	7
+NX_Q9NWH2	Transmembrane protein 242	141	14758	9.17	2	Membrane	NA	NA	NA	Belongs to the TMEM242 family.	NA	PE1	6
+NX_Q9NWH7	Spermatogenesis-associated protein 6	488	55989	8.8	0	Golgi apparatus;Secreted;Nucleoplasm;Flagellum;Cytoplasmic vesicle	NA	Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits.	NA	Belongs to the SPATA6 family.	NA	PE1	1
+NX_Q9NWH9	SAFB-like transcription modulator	1034	117148	7.69	0	Nucleoplasm;Nucleus	NA	When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.	NA	NA	NA	PE1	15
+NX_Q9NWK9	Box C/D snoRNA protein 1	470	53918	5.62	0	Cytoplasmic vesicle;Nucleus speckle	NA	Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.	NA	Belongs to the BCD1 family.	NA	PE1	1
+NX_Q9NWL6	Asparagine synthetase domain-containing protein 1	643	72080	6.4	0	Cytosol	NA	NA	NA	NA	NA	PE1	2
+NX_Q9NWM0	Spermine oxidase	555	61819	5.29	0	Cytoplasm;Nucleus membrane;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.	NA	Belongs to the flavin monoamine oxidase family.	Amine and polyamine degradation; spermine degradation.;PAOs oxidise polyamines to amines;Interconversion of polyamines	PE1	20
+NX_Q9NWM3	CUE domain-containing protein 1	386	42258	5.48	0	Cytosol;Centrosome;Cell membrane	NA	NA	NA	NA	NA	PE1	17
+NX_Q9NWM8	Peptidyl-prolyl cis-trans isomerase FKBP14	211	24172	5.7	0	Nucleoplasm;Golgi apparatus;Cytosol;Endoplasmic reticulum lumen	Ehlers-Danlos syndrome, kyphoscoliotic type, 2	PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens.	NA	NA	XBP1(S) activates chaperone genes	PE1	7
+NX_Q9NWN3	F-box only protein 34	711	78711	8.32	0	Nucleus speckle	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	NA	PE1	14
+NX_Q9NWQ4	G patch domain-containing protein 2-like	482	54260	8.77	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	14
+NX_Q9NWQ8	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1	432	46981	4.57	1	Cytoplasmic vesicle;Cell membrane	NA	Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.	Palmitoylated.;Phosphorylated by FYN on Tyr-317 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.	NA	Phosphorylation of CD3 and TCR zeta chains;GAB1 signalosome	PE1	8
+NX_Q9NWQ9	Uncharacterized protein C14orf119	140	16009	4.89	0	Cytosol;Mitochondrion	NA	NA	NA	NA	NA	PE1	14
+NX_Q9NWR8	Calcium uniporter regulatory subunit MCUb, mitochondrial	336	39082	9.23	2	Cytoplasmic vesicle;Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.	NA	Belongs to the MCU (TC 1.A.77) family.	Processing of SMDT1;Mitochondrial calcium ion transport	PE1	4
+NX_Q9NWS0	PIH1 domain-containing protein 1	290	32363	5.05	0	Cytosol;Nucleus	NA	Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451).	NA	Belongs to the PIH1 family.	NA	PE1	19
+NX_Q9NWS1	PCNA-interacting partner	579	65054	8.96	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.	NA	Belongs to the PARI family.	NA	PE1	12
+NX_Q9NWS6	Protein FAM118A	357	40269	5.7	1	Membrane;Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the FAM118 family.	NA	PE1	22
+NX_Q9NWS8	Required for meiotic nuclear division protein 1 homolog	449	51604	8.88	0	Mitochondrion	Combined oxidative phosphorylation deficiency 11	Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome (PubMed:23022098, PubMed:25604853).	NA	Belongs to the RMD1/sif2 family.	NA	PE1	6
+NX_Q9NWS9	Zinc finger protein 446	450	48957	5.72	0	Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9NWT1	p21-activated protein kinase-interacting protein 1	392	43964	9.07	0	Nucleolus	NA	Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868).	NA	NA	NA	PE1	6
+NX_Q9NWT6	Hypoxia-inducible factor 1-alpha inhibitor	349	40285	5.39	0	Cytoplasm;Nucleoplasm;Cytosol;Perinuclear region;Nucleus	NA	Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.	NA	NA	Cellular response to hypoxia	PE1	10
+NX_Q9NWT8	Aurora kinase A-interacting protein	199	22354	10.76	0	Nucleoplasm;Mitochondrion;Nucleus	NA	May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.	NA	Belongs to the mitochondrion-specific ribosomal protein mS38 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	1
+NX_Q9NWU1	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial	459	48843	7.59	0	Cytosol;Mitochondrion	NA	May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.	NA	Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Lipid metabolism; fatty acid biosynthesis.;Fatty acid biosynthesis;Metabolic pathways	PE1	3
+NX_Q9NWU2	Glucose-induced degradation protein 8 homolog	228	26749	4.92	0	Cytoplasm;Nucleoplasm;Cell junction;Nucleus	NA	Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046).	Polyubiquitinated through 'Lys-48'-polyubiquitin chains, leading to proteasomal degradation in the absence of Wnt stimulation.	Belongs to the GID8 family.	NA	PE1	20
+NX_Q9NWU5	39S ribosomal protein L22, mitochondrial	206	23641	9.95	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL22 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	5
+NX_Q9NWV4	CXXC motif containing zinc binding protein	160	18048	4.93	0	Cytoplasmic vesicle;Cytosol;Spindle	NA	NA	NA	Belongs to the UPF0587 family.	NA	PE1	1
+NX_Q9NWV8	BRISC and BRCA1-A complex member 1	329	36560	4.6	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).	NA	Belongs to the BABAM1 family.	G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Metalloprotease DUBs	PE1	19
+NX_Q9NWW0	Host cell factor C1 regulator 1	138	15291	6.83	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.	NA	NA	NA	PE1	16
+NX_Q9NWW5	Ceroid-lipofuscinosis neuronal protein 6	311	35919	8.94	7	Endoplasmic reticulum;Endoplasmic reticulum membrane;Nucleolus;Cytoplasmic vesicle	Ceroid lipofuscinosis, neuronal, 6;Ceroid lipofuscinosis, neuronal, 4A	NA	NA	NA	NA	PE1	15
+NX_Q9NWW6	Nicotinamide riboside kinase 1	199	23193	4.82	0	Nucleoplasm;Cytosol	NA	Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.	NA	Belongs to the uridine kinase family. NRK subfamily.	Cofactor biosynthesis; NAD(+) biosynthesis.;Nicotinate and nicotinamide metabolism;Nicotinate metabolism	PE1	9
+NX_Q9NWW7	Uncharacterized protein C2orf42	574	64077	9.15	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	2
+NX_Q9NWW9	Phospholipase A and acyltransferase 2	162	17394	9.3	1	Membrane;Cytoplasm	NA	Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22825852, PubMed:22605381). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22825852, PubMed:22605381). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor (PubMed:22605381). Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity (PubMed:22825852).	NA	Belongs to the H-rev107 family.	Acyl chain remodelling of PE	PE1	11
+NX_Q9NWX5	Ankyrin repeat and SOCS box protein 6	421	47136	5.62	0	Cytoplasm	NA	Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	9
+NX_Q9NWX6	Probable tRNA(His) guanylyltransferase	298	34831	8.12	0	Cytoplasm;Mitochondrion	NA	Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.	NA	Belongs to the tRNA(His) guanylyltransferase family.	tRNA modification in the nucleus and cytosol	PE1	5
+NX_Q9NWY4	Histone PARylation factor 1	346	39436	6.34	0	Nucleus	NA	Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine (PubMed:28190768, PubMed:29480802). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1 (PubMed:30257210).	NA	Belongs to the HPF1 family.	NA	PE1	4
+NX_Q9NWZ3	Interleukin-1 receptor-associated kinase 4	460	51530	5.24	0	Cytoplasm;Cytosol;Nucleolus;Cytoskeleton	Recurrent isolated invasive pneumococcal disease 1;IRAK4 deficiency	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.	Phosphorylated.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.	Apoptosis;Toll-like receptor signaling pathway;Neurotrophin signaling pathway;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Measles;Influenza A;PIP3 activates AKT signaling;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;IRAK4 deficiency (TLR5);IRAK4 deficiency (TLR2/4);TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 dependent cascade initiated on endosome;MyD88 cascade initiated on plasma membrane;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-1 signaling	PE1	12
+NX_Q9NWZ5	Uridine-cytidine kinase-like 1	548	61141	6.93	0	Endoplasmic reticulum;Cytoplasm;Nucleus	NA	May contribute to UTP accumulation needed for blast transformation and proliferation.	Ubiquitinated by RNF19B; which induces proteasomal degradation.	Belongs to the uridine kinase family.	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.;Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.;Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine salvage	PE1	20
+NX_Q9NWZ8	Gem-associated protein 8	242	28637	6.31	0	Nucleoplasm;Cytoplasm;Gem;Cytosol	NA	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.	NA	NA	RNA transport;snRNP Assembly	PE1	X
+NX_Q9NX00	Transmembrane protein 160	188	19658	7.84	3	Membrane	NA	NA	NA	Belongs to the TMEM160 family.	NA	PE1	19
+NX_Q9NX01	Thioredoxin-like protein 4B	149	17015	5.63	0	Nucleoplasm;Cytosol;Nucleus	NA	Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.	NA	Belongs to the DIM1 family.	NA	PE1	16
+NX_Q9NX02	NACHT, LRR and PYD domains-containing protein 2	1062	120515	5.74	0	Golgi apparatus;Cytoplasm;Cytosol;Cytoplasmic vesicle	NA	Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.	NA	Belongs to the NLRP family.	NA	PE1	19
+NX_Q9NX04	Uncharacterized protein C1orf109	203	23373	5.47	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	May promote cancer cell proliferation by controlling the G1 to S phase transition.	Phosphorylated on serines by CK2 kinase.	NA	NA	PE1	1
+NX_Q9NX05	Constitutive coactivator of PPAR-gamma-like protein 2	1096	120588	9.19	0	Nucleus speckle	NA	NA	NA	Belongs to the constitutive coactivator of PPAR-gamma family.	NA	PE1	X
+NX_Q9NX07	tRNA selenocysteine 1-associated protein 1	287	32499	4.61	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).	NA	Belongs to the RRM TRSPAP family.	NA	PE1	1
+NX_Q9NX08	COMM domain-containing protein 8	183	21090	5.3	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).	NA	NA	Neddylation	PE1	4
+NX_Q9NX09	DNA damage-inducible transcript 4 protein	232	25371	4.87	0	Cytoplasm;Cytosol;Mitochondrion;Nucleus	NA	Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.	Phosphorylated by GSK3B; this promotes proteasomal degradation.;Polyubiquitinated by a DCX (DDB1-CUL4A-RBX1) E3 ubiquitin-protein ligase complex with BTRC as substrate-recognition component, leading to its proteasomal degradation.	Belongs to the DDIT4 family.	mTOR signaling pathway;TP53 Regulates Metabolic Genes	PE1	10
+NX_Q9NX14	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial	153	17317	5.17	1	Mitochondrion inner membrane;Mitochondrion	Linear skin defects with multiple congenital anomalies 3;Mitochondrial complex I deficiency, nuclear type 30	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFB11 subunit family.	Oxidative phosphorylation;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	X
+NX_Q9NX18	Succinate dehydrogenase assembly factor 2, mitochondrial	166	19599	6.33	0	Mitochondrion matrix;Mitochondrion;Nucleolus;Cytosol	Paragangliomas 2	Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.	NA	Belongs to the SDHAF2 family.	NA	PE1	11
+NX_Q9NX20	39S ribosomal protein L16, mitochondrial	251	28449	10.13	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL16 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	11
+NX_Q9NX24	H/ACA ribonucleoprotein complex subunit 2	153	17201	8.48	0	Cajal body;Nucleoplasm;Cytosol;Nucleolus	Dyskeratosis congenita, autosomal recessive, 2	Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.	NA	Belongs to the eukaryotic ribosomal protein eL8 family.	Ribosome biogenesis in eukaryotes;Telomere Extension By Telomerase;rRNA modification in the nucleus and cytosol	PE1	5
+NX_Q9NX31	Oxidative stress-responsive serine-rich protein 1	292	31779	8.74	0	Nucleus speckle;Nucleolus	NA	NA	NA	NA	NA	PE1	20
+NX_Q9NX36	DnaJ homolog subfamily C member 28	388	45806	9.57	0	NA	NA	May have a role in protein folding or as a chaperone.	NA	NA	NA	PE1	21
+NX_Q9NX38	Protein Abitram	181	20378	8.12	0	Nucleus speckle;Growth cone;Nucleoplasm;Lamellipodium;Cytosol;Dendrite;Nucleus;Cytoskeleton	NA	Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons.	NA	Belongs to the ABITRAM family.	NA	PE1	9
+NX_Q9NX40	OCIA domain-containing protein 1	245	27626	7.02	0	Endosome;Mitochondrion	NA	Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946).	NA	Belongs to the OCIAD1 family.	NA	PE1	4
+NX_Q9NX45	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2	425	46941	6.79	0	Cytoplasm;Nucleus;Cytoplasmic vesicle	NA	Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity).	NA	NA	NA	PE1	13
+NX_Q9NX46	ADP-ribose glycohydrolase ARH3	363	38947	4.95	0	Cytoplasm;Mitochondrion matrix;Chromosome;Nucleoplasm;Nucleus	Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures	ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose (PubMed:21498885, PubMed:30045870, PubMed:29907568, PubMed:30401461). Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (PubMed:28650317, PubMed:29234005, PubMed:30045870). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds (PubMed:16278211). Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (PubMed:16278211). Also hydrolyzes free poly(ADP-ribose) in mitochondria (PubMed:22433848). Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins (PubMed:17075046, PubMed:21498885). Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers (PubMed:21498885).	NA	Belongs to the ADP-ribosylglycohydrolase family.	POLB-Dependent Long Patch Base Excision Repair	PE1	1
+NX_Q9NX47	E3 ubiquitin-protein ligase MARCH5	278	31232	9	4	Mitochondrion outer membrane;Endoplasmic reticulum membrane;Mitochondrion	NA	Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.	Autoubiquitinated leading to degradation (short half-life).	NA	Protein modification; protein ubiquitination.	PE1	10
+NX_Q9NX52	Rhomboid-related protein 2	303	34021	6.61	7	Cell membrane	NA	Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.	Proteolytic processing of the proenzyme produces a N-terminal fragment (NTF) and a C-terminal fragment (CTF). The processing is required for activation of the protease.	Belongs to the peptidase S54 family.	NA	PE1	1
+NX_Q9NX55	Huntingtin-interacting protein K	129	14665	4.9	0	Cytoplasm;Nucleoplasm;Nucleus;Cytoskeleton	NA	Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation.	NA	NA	NA	PE1	15
+NX_Q9NX57	Ras-related protein Rab-20	234	26277	6.12	0	Golgi apparatus;Cytoplasmic vesicle;Phagosome membrane;Phagosome	NA	Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.	NA	Belongs to the small GTPase superfamily. Rab family.	RAB geranylgeranylation	PE1	13
+NX_Q9NX58	Cell growth-regulating nucleolar protein	379	43615	9.57	0	Cytoplasm;Photoreceptor outer segment;Nucleolus;Nucleoplasm;Nucleus	NA	Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).	NA	NA	NA	PE1	4
+NX_Q9NX61	Transmembrane protein 161A	479	53602	8.75	8	Membrane;Cytosol	NA	May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.	NA	Belongs to the TMEM161 family.	NA	PE1	19
+NX_Q9NX62	Inositol monophosphatase 3	359	38681	6.38	1	Golgi apparatus;Nucleoplasm;Cytosol;trans-Golgi network membrane	Chondrodysplasia with joint dislocations, GPAPP type	May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation.	Contains N-linked glycan resistant to endoglycosydase H.	Belongs to the inositol monophosphatase superfamily.	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.;Cytosolic sulfonation of small molecules	PE1	8
+NX_Q9NX63	MICOS complex subunit MIC19	227	26152	8.48	0	Cytoplasm;Mitochondrion inner membrane;Mitochondrion;Nucleus	NA	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180).	NA	Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic19 subfamily.	Mitochondrial protein import;Cristae formation	PE1	7
+NX_Q9NX65	Zinc finger and SCAN domain-containing protein 32	697	78728	8.37	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	16
+NX_Q9NX70	Mediator of RNA polymerase II transcription subunit 29	200	21073	5.86	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 29 family.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	19
+NX_Q9NX74	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like	493	55050	6.74	0	Endoplasmic reticulum;Cytosol;Cytoplasm	NA	Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616).	NA	Belongs to the Dus family. Dus2 subfamily.	tRNA modification in the nucleus and cytosol	PE1	16
+NX_Q9NX76	CKLF-like MARVEL transmembrane domain-containing protein 6	183	20419	5.23	4	Early endosome membrane;Cytoplasmic vesicle;Recycling endosome membrane;Cell membrane	NA	Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.	NA	Belongs to the chemokine-like factor family.	Neutrophil degranulation	PE1	3
+NX_Q9NX77	Endogenous retrovirus group K member 13-1 Env polyprotein	482	55045	8.96	1	Virion;Cell membrane	NA	TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).;SU mediates receptor recognition.;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity).	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-4) env subfamily.	NA	PE2	16
+NX_Q9NX78	Transmembrane protein 260	707	79536	8.67	8	Membrane;Nucleoplasm;Cytosol;Focal adhesion	Structural heart defects and renal anomalies syndrome	NA	NA	Belongs to the TMEM260 family.	NA	PE1	14
+NX_Q9NX94	WW domain binding protein 1-like	342	37828	5.02	1	Membrane;Nucleoplasm;Cytoskeleton	NA	NA	NA	NA	NA	PE1	10
+NX_Q9NX95	Syntabulin	663	72388	5.87	1	Cytoplasmic vesicle;Golgi apparatus membrane;Cytoskeleton	NA	Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.	NA	NA	NA	PE1	8
+NX_Q9NXA8	NAD-dependent protein deacylase sirtuin-5, mitochondrial	310	33881	8.82	0	Cytoplasm;Mitochondrion;Mitochondrion matrix;Mitochondrion intermembrane space;Cytosol;Nucleus	NA	NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.	NA	Belongs to the sirtuin family. Class III subfamily.	Transcriptional activation of mitochondrial biogenesis	PE1	6
+NX_Q9NXB0	Meckel syndrome type 1 protein	559	64528	6.04	0	Centrosome;Cilium basal body	Bardet-Biedl syndrome 13;Meckel syndrome 1;Joubert syndrome 28	Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.	NA	NA	Anchoring of the basal body to the plasma membrane;Hedgehog 'off' state	PE1	17
+NX_Q9NXB9	Elongation of very long chain fatty acids protein 2	296	34585	9.32	7	Endoplasmic reticulum membrane	NA	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.	NA	Belongs to the ELO family. ELOVL2 subfamily.	Lipid metabolism; polyunsaturated fatty acid biosynthesis.;Fatty acid elongation;Biosynthesis of unsaturated fatty acids;Synthesis of very long-chain fatty acyl-CoAs;Linoleic acid (LA) metabolism;alpha-linolenic acid (ALA) metabolism	PE1	6
+NX_Q9NXC2	Glucose-fructose oxidoreductase domain-containing protein 1	390	43158	5.63	0	Nucleoplasm;Cytosol;Secreted;Cell membrane	NA	NA	NA	Belongs to the Gfo/Idh/MocA family.	NA	PE1	6
+NX_Q9NXC5	GATOR complex protein MIOS	875	98584	6.29	0	Nucleoplasm;Cytosol;Lysosome membrane	NA	As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).	NA	Belongs to the WD repeat mio family.	NA	PE1	7
+NX_Q9NXD2	Myotubularin-related protein 10	777	88273	8.78	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Synthesis of PIPs at the early endosome membrane	PE1	15
+NX_Q9NXE4	Sphingomyelin phosphodiesterase 4	866	97810	8.5	1	Endoplasmic reticulum membrane;Nucleus membrane;Nucleus envelope;Golgi apparatus membrane;Cytosol	NA	Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924).	NA	NA	Sphingolipid metabolism;Metabolic pathways;Glycosphingolipid metabolism	PE1	2
+NX_Q9NXE8	Pre-mRNA-splicing factor CWC25 homolog	425	49647	10.18	0	Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing as component of the spliceosome.	NA	Belongs to the CWC25 family.	mRNA Splicing - Major Pathway	PE1	17
+NX_Q9NXF1	Testis-expressed protein 10	929	105674	9.43	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).	NA	Belongs to the IPI1/TEX10 family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	9
+NX_Q9NXF7	DDB1- and CUL4-associated factor 16	216	24193	5.71	0	Cytosol;Nucleus;Cell membrane	NA	Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.	NA	NA	Protein modification; protein ubiquitination.;Neddylation	PE1	4
+NX_Q9NXF8	Palmitoyltransferase ZDHHC7	308	35140	8.28	4	Golgi apparatus;Nucleoplasm;Golgi apparatus membrane	NA	Palmitoyltransferase with broad specificity (PubMed:22031296, PubMed:28196865). Palmitoylates JAM3 (PubMed:28196865). Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).	Autopalmitoylated.	Belongs to the DHHC palmitoyltransferase family.	Extra-nuclear estrogen signaling	PE1	16
+NX_Q9NXG0	Centlein	1405	161571	8.28	0	Nucleoplasm;Cytosol;Centrosome;Centriole	NA	Required for centrosome cohesion and recruitment of CEP68 to centrosomes.	Phosphorylated directly or indirectly by NEK2.	NA	NA	PE1	9
+NX_Q9NXG2	THUMP domain-containing protein 1	353	39315	8.01	0	Cytosol	NA	Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation (PubMed:25653167).	NA	Belongs to the THUMPD1 family.	rRNA modification in the nucleus and cytosol	PE1	16
+NX_Q9NXG6	Transmembrane prolyl 4-hydroxylase	502	56661	5.68	1	Cytoplasmic vesicle;Cytosol;Endoplasmic reticulum membrane	NA	Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.	Glycosylated.	NA	NA	PE1	3
+NX_Q9NXH3	Protein phosphatase 1 regulatory subunit 14D	145	16508	7.72	0	Cytoplasm	NA	Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.	Phosphorylated on several residues.	Belongs to the PP1 inhibitor family.	NA	PE1	15
+NX_Q9NXH8	Torsin-4A	423	46914	9.98	1	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the ClpA/ClpB family. Torsin subfamily.	Platelet degranulation	PE1	9
+NX_Q9NXH9	tRNA (guanine(26)-N(2))-dimethyltransferase	659	72234	7.77	0	Nucleoplasm;Cytosol;Cell membrane	Intellectual developmental disorder, autosomal recessive 68	Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.	tRNA modification in the nucleus and cytosol	PE1	19
+NX_Q9NXI6	E3 ubiquitin-protein ligase RNF186	227	24145	7.02	2	Endoplasmic reticulum membrane	NA	E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress (PubMed:23896122). In that process, stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis (PubMed:23896122).	Polyubiquitinated. 'Lys-29'-linked autoubiquitination leads to proteasomal degradation.	NA	Protein modification; protein ubiquitination.	PE1	1
+NX_Q9NXJ0	Membrane-spanning 4-domains subfamily A member 12	267	28069	6.81	4	Golgi apparatus;Cell membrane;Nucleolus;Membrane;Endoplasmic reticulum;Cytosol	NA	May be involved in signal transduction as a component of a multimeric receptor complex.	NA	Belongs to the MS4A family.	NA	PE1	11
+NX_Q9NXJ5	Pyroglutamyl-peptidase 1	209	23138	5.54	0	Golgi apparatus;Cytoplasm	NA	Removes 5-oxoproline from various penultimate amino acid residues except L-proline.	NA	Belongs to the peptidase C15 family.	NA	PE1	19
+NX_Q9NXK6	Membrane progestin receptor gamma	330	38014	8.6	7	Cytoplasmic vesicle;Cell membrane	NA	Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167).	NA	Belongs to the ADIPOR family.	NA	PE1	15
+NX_Q9NXK8	F-box/LRR-repeat protein 12	326	37026	9.11	0	Mitochondrion	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	19
+NX_Q9NXL2	Rho guanine nucleotide exchange factor 38	777	89078	5.87	0	Nucleoplasm;Centrosome	NA	May act as a guanine-nucleotide releasing factor.	NA	NA	Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events	PE1	4
+NX_Q9NXL6	SID1 transmembrane family member 1	827	93839	6.95	11	Membrane	NA	In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.	NA	Belongs to the SID1 family.	NA	PE1	3
+NX_Q9NXL9	DNA helicase MCM9	1143	127313	7.87	0	Nucleoplasm;Nucleus;Chromosome	Ovarian dysgenesis 4	Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity).	NA	Belongs to the MCM family.	NA	PE1	6
+NX_Q9NXN4	Ganglioside-induced differentiation-associated protein 2	497	56225	5.48	0	Endoplasmic reticulum	Spinocerebellar ataxia, autosomal recessive, 27	NA	NA	Belongs to the GDAP2 family.	NA	PE1	1
+NX_Q9NXP7	Gypsy retrotransposon integrase-like protein 1	522	59842	8.01	0	Nucleoplasm;Nucleolus	NA	NA	NA	NA	NA	PE1	5
+NX_Q9NXR1	Nuclear distribution protein nudE homolog 1	335	37721	5.09	0	Cleavage furrow;Centrosome;Spindle;Kinetochore;Cytoskeleton	Microhydranencephaly;Lissencephaly 4	Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.	Phosphorylated in mitosis. Phosphorylated in vitro by CDC2. Phosphorylation at Thr-246 is essential for the G2/M transition (By similarity).	Belongs to the nudE family.	Separation of Sister Chromatids;Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Recruitment of NuMA to mitotic centrosomes;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;AURKA Activation by TPX2	PE1	16
+NX_Q9NXR5	Ankyrin repeat domain-containing protein 10	420	44768	5.58	0	Cytosol;Cytoskeleton	NA	NA	NA	NA	NA	PE1	13
+NX_Q9NXR7	BRISC and BRCA1-A complex member 2	383	43552	5.53	0	Cytoplasm;Cytosol;Nucleus	NA	Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831).	NA	Belongs to the BABAM2 family.	G2/M DNA damage checkpoint;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Nonhomologous End-Joining (NHEJ);Metalloprotease DUBs	PE1	2
+NX_Q9NXR8	Inhibitor of growth protein 3	418	46743	5.88	0	Nucleoplasm;Nucleus	Squamous cell carcinoma of the head and neck	Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.	NA	Belongs to the ING family.	HATs acetylate histones	PE1	7
+NX_Q9NXS2	Glutaminyl-peptide cyclotransferase-like protein	382	42924	9.84	1	Golgi apparatus;Golgi apparatus membrane	NA	Responsible for the biosynthesis of pyroglutamyl peptides.	NA	Belongs to the glutaminyl-peptide cyclotransferase family.	NA	PE1	19
+NX_Q9NXS3	Kelch-like protein 28	571	64192	5.74	0	Cytosol	NA	NA	NA	NA	NA	PE1	14
+NX_Q9NXT0	Zinc finger protein 586	402	46413	9.14	0	Cytoplasmic vesicle;Nucleolus;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9NXU5	ADP-ribosylation factor-like protein 15	204	22876	5.41	0	Golgi apparatus;Cell junction;Cell membrane	NA	NA	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	5
+NX_Q9NXV2	BTB/POZ domain-containing protein KCTD5	234	26093	5.89	0	Cytoplasm;Cytosol;Nucleus	NA	Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (PubMed:18573101). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (PubMed:19361449).	NA	NA	NA	PE1	16
+NX_Q9NXV6	CDKN2A-interacting protein	580	61125	9.13	0	Nucleoplasm	NA	Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.	May be ubiquitinated.	Belongs to the CARF family.	NA	PE1	4
+NX_Q9NXW2	DnaJ homolog subfamily B member 12	375	41860	8.81	1	Endoplasmic reticulum;Endoplasmic reticulum membrane;Nucleus membrane	NA	(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744).;Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21150129, PubMed:21148293). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912).	NA	Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.	Protein processing in endoplasmic reticulum	PE1	10
+NX_Q9NXW9	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4	302	33838	6.27	0	Midbody;Nucleolus;Cytoplasm;Nucleus	NA	Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity).	NA	Belongs to the alkB family.	NA	PE1	7
+NX_Q9NXX6	Non-structural maintenance of chromosomes element 4 homolog A	385	44301	5.25	0	Cytoplasm;Nucleoplasm;Telomere;Nucleus	NA	Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus.	NA	Belongs to the NSE4 family.	SUMOylation of DNA damage response and repair proteins	PE1	10
+NX_Q9NXZ1	Sarcoma antigen 1	904	99225	6.02	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	X
+NX_Q9NXZ2	Probable ATP-dependent RNA helicase DDX43	648	72844	8.91	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the DEAD box helicase family.	NA	PE1	6
+NX_Q9NY12	H/ACA ribonucleoprotein complex subunit 1	217	22348	10.91	0	Cajal body;Nucleoplasm;Nucleolus	NA	Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.	NA	Belongs to the GAR1 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol	PE1	4
+NX_Q9NY15	Stabilin-1	2570	275482	6.05	1	Membrane;Nucleoplasm;Cytosol;Cell membrane	NA	Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.	NA	NA	Scavenging by Class H Receptors	PE1	3
+NX_Q9NY25	C-type lectin domain family 5 member A	188	21521	9.04	1	Cytosol;Cell membrane	NA	Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (By similarity).;(Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (PubMed:18496526, PubMed:21566123). The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP (PubMed:18496526). This interaction does not result in viral entry, but stimulates proinflammatory cytokine release (PubMed:18496526).	N-glycosylated. Contains sialic acid residues.	NA	DAP12 interactions;Neutrophil degranulation	PE1	7
+NX_Q9NY26	Zinc transporter ZIP1	324	34250	5.6	8	Endoplasmic reticulum membrane;Cell membrane	NA	Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.	NA	Belongs to the ZIP transporter (TC 2.A.5) family.	Zinc influx into cells by the SLC39 gene family	PE1	1
+NX_Q9NY27	Serine/threonine-protein phosphatase 4 regulatory subunit 2	417	46898	4.48	0	Nucleoplasm;Centrosome;Nucleus	NA	Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.	NA	Belongs to the PPP4R2 family.	Processing of DNA double-strand break ends	PE1	3
+NX_Q9NY28	Probable polypeptide N-acetylgalactosaminyltransferase 8	637	72851	9.02	1	Golgi apparatus;Cytoplasmic vesicle;Golgi apparatus membrane	NA	Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.	NA	Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	12
+NX_Q9NY30	Protein BTG4	223	25970	8.86	0	Golgi apparatus;Endoplasmic reticulum	NA	Shows marked antiproliferative activity, being able to induce G(1) arrest.	NA	Belongs to the BTG family.	RNA degradation	PE1	11
+NX_Q9NY33	Dipeptidyl peptidase 3	737	82589	5.01	0	Cytosol	NA	Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758).	NA	Belongs to the peptidase M49 family.	NA	PE1	11
+NX_Q9NY35	Claudin domain-containing protein 1	253	28603	5.53	4	Membrane;Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	Belongs to the PMP-22/EMP/MP20 family.	NA	PE1	3
+NX_Q9NY37	Acid-sensing ion channel 5	505	57464	8.51	2	Cell membrane	NA	Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride.	NA	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily.	Stimuli-sensing channels	PE1	4
+NX_Q9NY43	BarH-like 2 homeobox protein	387	41981	8.67	0	Nucleus	NA	Potential regulator of neural basic helix-loop-helix genes.	NA	Belongs to the BAR homeobox family.	NA	PE1	1
+NX_Q9NY46	Sodium channel protein type 3 subunit alpha	2000	226294	5.6	24	Cell membrane	Epilepsy, familial focal, with variable foci 4;Epileptic encephalopathy, early infantile, 62	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:24157691, PubMed:28235671, PubMed:29466837). May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (By similarity). In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (By similarity).	May be ubiquitinated by NEDD4L; which would promote its endocytosis.;Phosphorylation at Ser-1501 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	2
+NX_Q9NY47	Voltage-dependent calcium channel subunit alpha-2/delta-2	1150	129817	5.54	1	Membrane;Cytoplasmic vesicle	NA	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.	May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).	Belongs to the calcium channel subunit alpha-2/delta family.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Adrenaline,noradrenaline inhibits insulin secretion;Presynaptic depolarization and calcium channel opening;Regulation of insulin secretion;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	3
+NX_Q9NY56	Odorant-binding protein 2a	170	19318	8.37	0	Secreted	NA	Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids.	NA	Belongs to the calycin superfamily. Lipocalin family.	NA	PE1	9
+NX_Q9NY57	Serine/threonine-protein kinase 32B	414	47883	7.63	0	Cytoplasmic vesicle;Cytoskeleton	NA	NA	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	4
+NX_Q9NY59	Sphingomyelin phosphodiesterase 3	655	71081	5.52	0	Endoplasmic reticulum;Cell membrane;Golgi apparatus membrane	NA	Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.	Palmitoylated, palmitoylation-deficient proteins are targeted for lysosomal degradation.	Belongs to the neutral sphingomyelinase family.	Lipid metabolism; sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;Glycosphingolipid metabolism;TNFR1-mediated ceramide production	PE1	16
+NX_Q9NY61	Protein AATF	560	63133	4.83	0	Nucleoplasm;Nucleolus	NA	May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.	Hyperphosphorylated during the G1/S phase transition.;AATF is phosphorylated by ATR	Belongs to the AATF family.	NRAGE signals death through JNK	PE1	17
+NX_Q9NY64	Solute carrier family 2, facilitated glucose transporter member 8	477	50819	7.55	12	Cytoplasmic vesicle;Cytoplasmic vesicle membrane;Cell membrane	NA	Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.	NA	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Cellular hexose transport;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	9
+NX_Q9NY65	Tubulin alpha-8 chain	449	50094	4.94	0	Cytoskeleton	Cortical dysplasia, complex, with other brain malformations 8	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).;Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).	Belongs to the tubulin family.	Phagosome;Gap junction;Pathogenic Escherichia coli infection;Separation of Sister Chromatids;MHC class II antigen presentation;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Kinesins;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Cilium Assembly;Recruitment of NuMA to mitotic centrosomes;Gap junction assembly;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;RHO GTPases activate IQGAPs;The role of GTSE1 in G2/M progression after G2 checkpoint;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;HSP90 chaperone cycle for steroid hormone receptors (SHR);Carboxyterminal post-translational modifications of tubulin;Assembly and cell surface presentation of NMDA receptors;Activation of AMPK downstream of NMDARs	PE1	22
+NX_Q9NY72	Sodium channel subunit beta-3	215	24702	4.69	1	Golgi apparatus;Cell membrane;Membrane;Cytosol;Cytoskeleton	Atrial fibrillation, familial, 16;Brugada syndrome 7	Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).	NA	Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	11
+NX_Q9NY74	Ewing's tumor-associated antigen 1	926	103440	7.71	0	Nucleoplasm;Cytosol;Nucleus	NA	Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723720, PubMed:27723717). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723720, PubMed:27723717). Probably only regulates a subset of ATR targets (PubMed:27723720, PubMed:27723717).	Phosphorylated by ATR.	NA	NA	PE1	2
+NX_Q9NY84	Vascular non-inflammatory molecule 3	501	56118	5.66	0	Cell membrane	NA	Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.	NA	Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.	Post-translational modification: synthesis of GPI-anchored proteins	PE2	6
+NX_Q9NY87	Sperm protein associated with the nucleus on the X chromosome C	97	10982	5.22	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the SPAN-X family.	NA	PE1	X
+NX_Q9NY91	Solute carrier family 5 member 4	659	72456	5.8	11	Cell membrane	NA	Has electrogenic activity in response to glucose, and may function as a glucose sensor (PubMed:13130073, PubMed:17110502, PubMed:20421923, PubMed:22766068). Mediates influx of sodium ions into the cell but does not transport sugars (PubMed:13130073, PubMed:22766068). Also potently activated by imino sugars such as deoxynojirimycin (DNJ) (PubMed:17110502, PubMed:20421923, PubMed:22766068).	NA	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Cellular hexose transport	PE1	22
+NX_Q9NY93	Probable ATP-dependent RNA helicase DDX56	547	61590	9.34	0	Nucleolus;Nucleus	NA	May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity.	NA	Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.	NA	PE1	7
+NX_Q9NY97	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2	397	46022	8.75	1	Cytoplasmic vesicle;Golgi apparatus membrane	NA	Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase.	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Glycosaminoglycan biosynthesis - keratan sulfate;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;O-linked glycosylation of mucins;Keratan sulfate biosynthesis	PE1	2
+NX_Q9NY99	Gamma-2-syntrophin	539	60217	7.59	0	Sarcolemma;Cytoskeleton	NA	Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).	NA	Belongs to the syntrophin family.	NA	PE1	2
+NX_Q9NYA1	Sphingosine kinase 1	384	42518	6.64	0	Cytoplasm;Cell membrane;Endosome membrane;Clathrin-coated pit;Synapse;Cytosol;Nucleus	NA	Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.;Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (PubMed:20577214, PubMed:23602659, PubMed:29662056, PubMed:24929359, PubMed:11923095). In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis (PubMed:16118219). Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion (PubMed:20577214). In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway (PubMed:23935096). Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity (PubMed:28049734, PubMed:24929359). In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA (PubMed:25417698).	NA	NA	Sphingolipid metabolism;Metabolic pathways;Calcium signaling pathway;VEGF signaling pathway;Fc gamma R-mediated phagocytosis;Tuberculosis;Sphingolipid de novo biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;VEGFR2 mediated cell proliferation;Extra-nuclear estrogen signaling	PE1	17
+NX_Q9NYA3	Golgin subfamily A member 6A	693	79946	5.34	0	NA	NA	NA	NA	Belongs to the GOLGA6 family.	NA	PE2	15
+NX_Q9NYA4	Myotubularin-related protein 4	1195	133353	5.68	0	Membrane;Cytoplasm	NA	Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Downregulation of TGF-beta receptor signaling	PE1	17
+NX_Q9NYB0	Telomeric repeat-binding factor 2-interacting protein 1	399	44260	4.64	0	Cytoplasm;Chromosome;Nucleoplasm;Telomere;Nucleus	NA	Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.	NA	Belongs to the RAP1 family.	Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine	PE1	16
+NX_Q9NYB5	Solute carrier organic anion transporter family member 1C1	712	78696	8.82	12	Cell membrane	NA	Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain (By similarity).	NA	Belongs to the organo anion transporter (TC 2.A.60) family.	Transport of organic anions	PE2	12
+NX_Q9NYB9	Abl interactor 2	513	55663	5.82	0	Cytoplasm;Adherens junction;Nucleoplasm;Lamellipodium;Filopodium;Cytoplasmic vesicle;Nucleus;Cytoskeleton	NA	Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692).	Phosphorylated by ABL1.	Belongs to the ABI family.	Regulation of actin cytoskeleton;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;VEGFA-VEGFR2 Pathway	PE1	2
+NX_Q9NYC9	Dynein heavy chain 9, axonemal	4486	511877	5.64	0	Cilium axoneme	Ciliary dyskinesia, primary, 40	Force generating protein required for cilia beating in respiratory epithelia (PubMed:30471717, PubMed:30471718). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.	NA	Belongs to the dynein heavy chain family.	NA	PE1	17
+NX_Q9NYD6	Homeobox protein Hox-C10	342	38073	8.45	0	Nucleoplasm;Nucleus	NA	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	NA	Belongs to the Abd-B homeobox family.	NA	PE1	12
+NX_Q9NYF0	Dapper homolog 1	836	90174	8.93	0	Nucleoplasm;Cytoplasm;Nucleus;Synapse	Neural tube defects;Townes-Brocks syndrome 2	Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.	NA	Belongs to the dapper family.	Degradation of DVL	PE1	14
+NX_Q9NYF3	Protein FAM53C	392	43091	9	0	NA	NA	NA	NA	Belongs to the FAM53 family.	NA	PE1	5
+NX_Q9NYF5	Protein FAM13B	915	104543	4.87	0	Nucleoplasm	NA	NA	NA	Belongs to the FAM13 family.	Rho GTPase cycle	PE1	5
+NX_Q9NYF8	Bcl-2-associated transcription factor 1	920	106122	9.99	0	Cytoplasm;Nucleoplasm;Nucleus speckle;Nucleus	NA	Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.	Citrullinated by PADI4.	Belongs to the BCLAF1/THRAP3 family.	NA	PE1	6
+NX_Q9NYG2	Palmitoyltransferase ZDHHC3	299	34170	8.54	4	Golgi apparatus;Golgi apparatus membrane	NA	Palmitoyltransferase with broad specificity (PubMed:21926431, PubMed:23034182). Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability (By similarity). Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25 (By similarity).	Autopalmitoylated.	Belongs to the DHHC palmitoyltransferase family.	NA	PE1	3
+NX_Q9NYG5	Anaphase-promoting complex subunit 11	84	9841	7.99	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.	Auto-ubiquitinated.	Belongs to the RING-box family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	17
+NX_Q9NYG8	Potassium channel subfamily K member 4	393	42704	8.91	4	Cell membrane	Facial dysmorphism, hypertrichosis, epilepsy, intellectual and developmental delay, and gingival overgrowth syndrome	Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157, PubMed:30290154). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).	N-glycosylated.	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	TWIK related potassium channel (TREK);Phase 4 - resting membrane potential	PE1	11
+NX_Q9NYH9	U3 small nucleolar RNA-associated protein 6 homolog	597	70194	6.92	0	Nucleolus	NA	Involved in nucleolar processing of pre-18S ribosomal RNA.	NA	Belongs to the UTP6 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	17
+NX_Q9NYI0	PH and SEC7 domain-containing protein 3	1048	116034	5.68	0	Cell membrane;Nucleoplasm;Postsynaptic density;Ruffle membrane;Cytoplasmic vesicle;Cytosol	NA	Guanine nucleotide exchange factor for ARF6.	NA	NA	Endocytosis	PE1	8
+NX_Q9NYJ1	Cytochrome c oxidase assembly factor 4 homolog, mitochondrial	87	10134	5.65	0	Cytoplasm;Mitochondrion;Nucleolus;Nucleoplasm;Nucleus	NA	Putative COX assembly factor.	NA	Belongs to the COA4 family.	Mitochondrial protein import	PE1	11
+NX_Q9NYJ7	Delta-like protein 3	618	64618	7.86	1	Membrane;Nucleoplasm;Cell membrane	Spondylocostal dysostosis 1, autosomal recessive	Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).	Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.	NA	Notch signaling pathway	PE1	19
+NX_Q9NYJ8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2	693	76494	8.8	0	Membrane;Cytosol	Congenital heart defects, multiple types, 2	Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.	Phosphorylated.;Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation.	NA	MAPK signaling pathway;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;Leishmaniasis;Toxoplasmosis;Measles;Herpes simplex infection;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Downstream TCR signaling;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Nuclear signaling by ERBB4;TRAF6-mediated induction of TAK1 complex within TLR4 complex;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;IRAK2 mediated activation of TAK1 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;TNFR1-induced NFkappaB signaling pathway;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling	PE1	6
+NX_Q9NYK1	Toll-like receptor 7	1049	120922	8.51	1	Endosome;Endoplasmic reticulum membrane;Phagosome;Lysosome	NA	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).	NA	Belongs to the Toll-like receptor family.	Toll-like receptor signaling pathway;Measles;Influenza A;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 dependent cascade initiated on endosome;Trafficking and processing of endosomal TLR;Toll Like Receptor 7/8 (TLR7/8) Cascade	PE1	X
+NX_Q9NYK5	39S ribosomal protein L39, mitochondrial	338	38712	7.56	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL39 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	21
+NX_Q9NYK6	Protein EURL homolog	297	33948	6.1	0	Cytoplasm;Cytoskeleton	NA	Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway.	NA	Belongs to the EURL family.	NA	PE1	21
+NX_Q9NYL2	Mitogen-activated protein kinase kinase kinase 20	800	91155	7.9	0	Cytoplasm;Cytosol;Nucleus	Split-foot malformation with mesoaxial polydactyly;Myopathy, centronuclear, 6, with fiber-type disproportion	Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).;Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway;Tight junction	PE1	2
+NX_Q9NYL4	Peptidyl-prolyl cis-trans isomerase FKBP11	201	22180	9.44	1	Membrane;Centrosome	NA	PPIases accelerate the folding of proteins during protein synthesis.	NA	Belongs to the FKBP-type PPIase family.	NA	PE1	12
+NX_Q9NYL5	24-hydroxycholesterol 7-alpha-hydroxylase	469	54116	8.85	0	Microsome membrane;Endoplasmic reticulum membrane	NA	Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha-hydroxylated product.	NA	Belongs to the cytochrome P450 family.	Primary bile acid biosynthesis;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Endogenous sterols	PE1	6
+NX_Q9NYL9	Tropomodulin-3	352	39595	5.08	0	Cytosol;Cytoskeleton	NA	Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).	NA	Belongs to the tropomodulin family.	Striated Muscle Contraction	PE1	15
+NX_Q9NYM4	Probable G-protein coupled receptor 83	423	48339	9.32	7	Cell membrane	NA	Orphan receptor. Could be a neuropeptide Y receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events	PE2	11
+NX_Q9NYM9	BET1-like protein	111	12388	7.87	1	Golgi apparatus;Nucleoplasm;trans-Golgi network membrane;Golgi apparatus membrane	NA	Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).	NA	NA	SNARE interactions in vesicular transport;Intra-Golgi traffic;COPI-mediated anterograde transport	PE1	11
+NX_Q9NYN1	Ras-like protein family member 12	266	29662	9.16	0	NA	NA	NA	NA	Belongs to the small GTPase superfamily. Ras family.	NA	PE1	15
+NX_Q9NYP3	Protein downstream neighbor of Son	566	62747	8.84	0	Nucleoplasm;Cytosol;Cell junction;Nucleus	Microcephaly, short stature, and limb abnormalities;Microcephaly-micromelia syndrome	Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability.	NA	Belongs to the DONSON family.	NA	PE1	21
+NX_Q9NYP7	Elongation of very long chain fatty acids protein 5	299	35293	9.49	7	Dendrite;Endoplasmic reticulum;Endoplasmic reticulum membrane	Spinocerebellar ataxia 38	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity) (PubMed:10970790, PubMed:20937905). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity).	NA	Belongs to the ELO family. ELOVL5 subfamily.	Lipid metabolism; polyunsaturated fatty acid biosynthesis.;Fatty acid elongation;Biosynthesis of unsaturated fatty acids;Synthesis of very long-chain fatty acyl-CoAs;Linoleic acid (LA) metabolism;alpha-linolenic acid (ALA) metabolism	PE1	6
+NX_Q9NYP8	Uncharacterized protein C21orf62	219	24886	8.31	0	NA	NA	NA	NA	NA	NA	PE2	21
+NX_Q9NYP9	Protein Mis18-alpha	233	25863	5.14	0	Chromosome;Nucleoplasm;Centromere;Cytosol;Nucleus	NA	Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.	NA	Belongs to the mis18 family.	Deposition of new CENPA-containing nucleosomes at the centromere	PE1	21
+NX_Q9NYQ3	Hydroxyacid oxidase 2	351	38839	7.57	0	Peroxisome	NA	Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.	NA	Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.	Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Peroxisome;Peroxisomal lipid metabolism;Peroxisomal protein import	PE1	1
+NX_Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	3014	329486	5.59	7	Cell membrane	Neural tube defects	Receptor that may have an important role in cell/cell signaling during nervous system formation.	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.	NA	PE1	22
+NX_Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	3312	358185	6.23	7	Cell membrane	NA	Receptor that may have an important role in cell/cell signaling during nervous system formation.	NA	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.	NA	PE1	3
+NX_Q9NYQ8	Protocadherin Fat 2	4349	479317	5	1	trans-Golgi network;Cell junction;Cell membrane	Spinocerebellar ataxia 45	Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).	NA	NA	NA	PE1	5
+NX_Q9NYR8	Retinol dehydrogenase 8	311	33755	8.74	3	Membrane	NA	Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Retinol metabolism;Metabolic pathways;The canonical retinoid cycle in rods (twilight vision)	PE1	19
+NX_Q9NYR9	NF-kappa-B inhibitor-interacting Ras-like protein 2	191	21508	8.22	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).	NA	Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.	RIP-mediated NFkB activation via ZBP1;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation	PE1	17
+NX_Q9NYS0	NF-kappa-B inhibitor-interacting Ras-like protein 1	192	21643	5.99	0	Cytoplasm;Cytoskeleton	NA	Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.	NA	Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.	RIP-mediated NFkB activation via ZBP1;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation	PE1	3
+NX_Q9NYS7	WD repeat and SOCS box-containing protein 2	404	45286	8.36	0	NA	NA	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	NA	Protein modification; protein ubiquitination.;Neddylation	PE1	12
+NX_Q9NYT0	Pleckstrin-2	353	39971	9.45	0	Cytoplasmic vesicle;Cytosol;Lamellipodium membrane;Cytoskeleton	NA	May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.	NA	NA	NA	PE1	14
+NX_Q9NYT6	Zinc finger protein 226	803	91921	9.01	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9NYU1	UDP-glucose:glycoprotein glucosyltransferase 2	1516	174735	6.43	0	Endoplasmic reticulum lumen;Endoplasmic reticulum-Golgi intermediate compartment	NA	Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.	NA	Belongs to the glycosyltransferase 8 family.	Protein modification; protein glycosylation.;Protein processing in endoplasmic reticulum;ER Quality Control Compartment (ERQC)	PE1	13
+NX_Q9NYU2	UDP-glucose:glycoprotein glucosyltransferase 1	1555	177190	5.42	0	Cytosol;Endoplasmic reticulum lumen;Endoplasmic reticulum-Golgi intermediate compartment	NA	Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.	NA	Belongs to the glycosyltransferase 8 family.	Protein modification; protein glycosylation.;Protein processing in endoplasmic reticulum;ER Quality Control Compartment (ERQC)	PE1	2
+NX_Q9NYV4	Cyclin-dependent kinase 12	1490	164155	9.46	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.	Phosphorylation at Thr-893 increases kinase activity.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	TP53 Regulates Transcription of DNA Repair Genes	PE1	17
+NX_Q9NYV6	RNA polymerase I-specific transcription initiation factor RRN3	651	74107	5.4	0	Nucleolus	NA	Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).	Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation.	Belongs to the RRN3 family.	RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape	PE1	16
+NX_Q9NYV7	Taste receptor type 2 member 16	291	33986	9.5	7	Cell membrane	NA	Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	7
+NX_Q9NYV8	Taste receptor type 2 member 14	317	36160	10.12	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	12
+NX_Q9NYV9	Taste receptor type 2 member 13	303	35118	9.68	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	12
+NX_Q9NYW0	Taste receptor type 2 member 10	307	35365	9.55	7	Membrane	NA	Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	12
+NX_Q9NYW1	Taste receptor type 2 member 9	312	35611	9.83	7	Membrane	NA	Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	12
+NX_Q9NYW2	Taste receptor type 2 member 8	309	35877	9.66	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	12
+NX_Q9NYW3	Taste receptor type 2 member 7	318	36550	9.69	7	Membrane	NA	Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	12
+NX_Q9NYW4	Taste receptor type 2 member 5	299	34505	9.86	7	Membrane;Nucleoplasm;Cytosol;Nucleolus	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	7
+NX_Q9NYW5	Taste receptor type 2 member 4	299	33841	9.85	7	Cilium membrane;Membrane	NA	Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	7
+NX_Q9NYW6	Taste receptor type 2 member 3	316	35915	9.72	7	Membrane	NA	Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE2	7
+NX_Q9NYW7	Taste receptor type 2 member 1	299	34333	9.87	7	Membrane	NA	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.	NA	Belongs to the G-protein coupled receptor T2R family.	Taste transduction;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)	PE1	5
+NX_Q9NYW8	RB-associated KRAB zinc finger protein	714	82995	7.02	0	Nucleoplasm;Nucleus	NA	May repress E2F-dependent transcription. May promote AR-dependent transcription.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	7
+NX_Q9NYX4	Neuron-specific vesicular protein calcyon	217	23434	6.43	1	Cytoplasmic vesicle membrane;Cell membrane	NA	Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.	Glycosylated.	Belongs to the NSG family.	Dopaminergic synapse	PE1	10
+NX_Q9NYY1	Interleukin-20	176	20072	8.92	0	Secreted	NA	Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.	NA	Belongs to the IL-10 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling	PE1	1
+NX_Q9NYY3	Serine/threonine-protein kinase PLK2	685	78237	8.52	0	Mitochondrion;Centriole;Nucleoplasm;Cytosol;Dendrite	NA	Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.	Catalytic activity is enhanced by phosphorylation of Thr-239.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	5
+NX_Q9NYY8	FAST kinase domain-containing protein 2, mitochondrial	710	81463	8.31	0	Mitochondrion;Mitochondrion nucleoid	NA	Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).	NA	Belongs to the FAST kinase family.	NA	PE1	2
+NX_Q9NYZ1	Golgi apparatus membrane protein TVP23 homolog B	205	23576	8.62	4	Membrane	NA	NA	NA	Belongs to the TVP23 family.	NA	PE1	17
+NX_Q9NYZ2	Mitoferrin-1	338	37323	9.33	6	Cytoplasm;Mitochondrion;Cell membrane;Cytosol;Mitochondrion inner membrane	NA	Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Mitochondrial iron-sulfur cluster biogenesis	PE1	8
+NX_Q9NYZ3	G2 and S phase-expressed protein 1	720	76645	9.45	0	Centrosome;Cytoskeleton;Cell membrane	NA	May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.	Phosphorylated in mitosis.	NA	p53 signaling pathway;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint	PE1	22
+NX_Q9NYZ4	Sialic acid-binding Ig-like lectin 8	499	54042	8.39	1	Membrane;Cytosol	NA	Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658).	NA	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q9NZ01	Very-long-chain enoyl-CoA reductase	308	36034	9.5	3	Endoplasmic reticulum;Endoplasmic reticulum membrane	Mental retardation, autosomal recessive 14	Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (PubMed:25049234). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (PubMed:12482854). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (PubMed:12482854). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (PubMed:12482854). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (PubMed:12482854). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (PubMed:25049234).	Glycosylated.	Belongs to the steroid 5-alpha reductase family.	Lipid metabolism; sphingolipid metabolism.;Lipid metabolism; fatty acid biosynthesis.;Fatty acid elongation;Biosynthesis of unsaturated fatty acids;Synthesis of very long-chain fatty acyl-CoAs	PE1	19
+NX_Q9NZ08	Endoplasmic reticulum aminopeptidase 1	941	107235	6.02	1	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane;Cell membrane	NA	Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.	N-glycosylated.	Belongs to the peptidase M1 family.	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	PE1	5
+NX_Q9NZ09	Ubiquitin-associated protein 1	502	55084	5.02	0	Cytoplasm;Cell membrane;Endosome;Cytoplasmic vesicle;Cytosol	Spastic paraplegia 80, autosomal dominant	Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:24284069, PubMed:22405001, PubMed:31203368).	NA	NA	Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	9
+NX_Q9NZ20	Group 3 secretory phospholipase A2	509	57167	9.35	0	Secreted;Centriole;Cell membrane	NA	PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl-phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1-palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis.	N-glycosylation does not affect the catalytic activity, but is required for proper secretion. A nonglycosylated form was observed in several cell types.;In several cell types, the N- and C-termini are cleaved off.	Belongs to the phospholipase A2 family.	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PE	PE1	22
+NX_Q9NZ32	Actin-related protein 10	417	46307	7.06	0	Nucleolus;Cytoskeleton	NA	NA	NA	Belongs to the actin family.	MHC class II antigen presentation;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;Neutrophil degranulation;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	14
+NX_Q9NZ38	Uncharacterized protein IDI2-AS1	188	21312	10.21	0	NA	NA	NA	NA	NA	NA	PE2	10
+NX_Q9NZ42	Gamma-secretase subunit PEN-2	101	12029	9.25	1	Golgi stack membrane;Membrane;Endoplasmic reticulum membrane;Cell membrane	Acne inversa, familial, 2, with or without Dowling-Degos disease	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).	NA	Belongs to the PEN-2 family.	Notch signaling pathway;Alzheimer's disease;EPH-ephrin mediated repulsion of cells;Amyloid fiber formation;Nuclear signaling by ERBB4;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Regulated proteolysis of p75NTR;NOTCH2 Activation and Transmission of Signal to the Nucleus;NRIF signals cell death from the nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3;NOTCH4 Activation and Transmission of Signal to the Nucleus	PE1	19
+NX_Q9NZ43	Vesicle transport protein USE1	259	29371	9.13	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.	NA	Belongs to the USE1 family.	SNARE interactions in vesicular transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	19
+NX_Q9NZ45	CDGSH iron-sulfur domain-containing protein 1	108	12199	9.2	1	Mitochondrion outer membrane;Cytoplasm;Mitochondrion	NA	Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions.	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	Belongs to the CISD protein family.	NA	PE1	10
+NX_Q9NZ52	ADP-ribosylation factor-binding protein GGA3	723	78315	5.41	0	Golgi apparatus;Endosome membrane;trans-Golgi network membrane;Recycling endosome membrane;Early endosome membrane	NA	Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). Nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:17553422, PubMed:15615712, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels intedepently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity).	Ubiquitinated.;Phosphorylated by CK2 and dephosphorylated by PP2A (By similarity). Phosphorylation of GGA3 allows the internal DXXLL motif to bind the VHS domain and to inhibit the recognition of cargo signals.;Proteolytically cleaved during apoptosis by CASP3.	Belongs to the GGA protein family.	Lysosome;Amyloid fiber formation;MET receptor recycling;TBC/RABGAPs	PE1	17
+NX_Q9NZ53	Podocalyxin-like protein 2	605	65076	4.27	1	Membrane;Cytoplasmic vesicle;Golgi apparatus	NA	Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins.	Glycosylated; contains chondroitin sulfate. Displays sialylated O-linked oligosaccharides.;Sulfation is necessary for interaction with SELL. Sialylated O-linked oligosaccharides are necessary for interaction with SELL, SELE and SELP.	Belongs to the podocalyxin family.	Cytosolic sulfonation of small molecules	PE1	3
+NX_Q9NZ56	Formin-2	1722	180106	5.32	0	Cell cortex;Cell membrane;Nucleolus;Cytoplasmic vesicle membrane;Cytosol;Perinuclear region;Nucleus;Cytoskeleton	Mental retardation, autosomal recessive 47	Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:22330775, PubMed:21730168). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:22330775, PubMed:21730168). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502).	NA	Belongs to the formin homology family. Cappuccino subfamily.	Dorso-ventral axis formation	PE1	1
+NX_Q9NZ63	Telomere length and silencing protein 1 homolog	289	33688	6.33	0	Nucleoplasm	NA	Involved in the regulation of telomeric heterochromatin assembly and control of telomere length.	NA	Belongs to the TLS1 family.	NA	PE1	9
+NX_Q9NZ71	Regulator of telomere elongation helicase 1	1219	133683	8.6	0	Nucleus speckle;Nucleus	Dyskeratosis congenita, autosomal dominant, 4;Dyskeratosis congenita, autosomal recessive, 5;Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 3	ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.	NA	Belongs to the helicase family. RAD3/XPD subfamily.	Cytosolic iron-sulfur cluster assembly;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	PE1	20
+NX_Q9NZ72	Stathmin-3	180	21017	6.99	0	Growth cone;Golgi apparatus;Cytosol;Axon	NA	Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.	N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.	Belongs to the stathmin family.	NA	PE1	20
+NX_Q9NZ81	Proline-rich protein 13	148	15385	9.75	0	Nucleoplasm;Nucleus;Cell membrane	NA	Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.	NA	NA	NA	PE1	12
+NX_Q9NZ94	Neuroligin-3	848	93895	5.94	1	Golgi apparatus;Cell junction;Synapse;Cell membrane	Asperger syndrome, X-linked, 1;Autism, X-linked 1	Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity).	NA	Belongs to the type-B carboxylesterase/lipase family.	Cell adhesion molecules (CAMs);Neurexins and neuroligins	PE1	X
+NX_Q9NZA1	Chloride intracellular channel protein 5	410	46503	4.71	1	Cytoplasm;Golgi apparatus;Cell cortex;Nucleus speckle;Cell membrane;Membrane;Centrosome;Apical cell membrane;Cytoskeleton	Deafness, autosomal recessive, 103	Required for normal hearing (PubMed:24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity).	NA	Belongs to the chloride channel CLIC family.	NA	PE1	6
+NX_Q9NZB2	Constitutive coactivator of PPAR-gamma-like protein 1	1118	121888	9.07	0	Cytoplasm;Cytosol;Cell membrane	NA	May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.	Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure.;Arg-982 is dimethylated, probably to asymmetric dimethylarginine.	Belongs to the constitutive coactivator of PPAR-gamma family.	NA	PE1	9
+NX_Q9NZB8	Molybdenum cofactor biosynthesis protein 1	636	70105	9.4	0	Cytosol;Cell membrane	Molybdenum cofactor deficiency, complementation group A	Probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.	NA	In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.;In the C-terminal section; belongs to the MoaC family.	Cofactor biosynthesis; molybdopterin biosynthesis.;Folate biosynthesis;Metabolic pathways;Sulfur relay system;Molybdenum cofactor biosynthesis	PE1	6
+NX_Q9NZC2	Triggering receptor expressed on myeloid cells 2	230	25447	5.84	1	Secreted;Cell membrane	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2	Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia (PubMed:27477018, PubMed:29518356). Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (By similarity). Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia (PubMed:27477018). Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin (PubMed:29794134). Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (By similarity). Required for microglial phagocytosis of apoptotic neurons (PubMed:24990881). Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (By similarity). Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (By similarity). It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (By similarity). During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (By similarity). Plays a role in microglial MTOR activation and metabolism (By similarity). Regulates age-related changes in microglial numbers (PubMed:29752066). Triggers activation of the immune responses in macrophages and dendritic cells (PubMed:10799849). Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). Involved in the positive regulation of osteoclast differentiation (PubMed:12925681).	Undergoes ectodomain shedding through proteolytic cleavage by ADAM10 and ADAM17 to produce a transmembrane segment, the TREM2 C-terminal fragment (TREM2-CTF), which is subsequently cleaved by gamma-secretase.	NA	Osteoclast differentiation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;DAP12 signaling;Other semaphorin interactions;DAP12 interactions	PE1	6
+NX_Q9NZC3	Glycerophosphodiester phosphodiesterase 1	331	37718	6.22	2	Cell membrane;Nucleolus;Cytoplasmic vesicle membrane;Nucleoplasm;Cytoplasmic vesicle	NA	Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).	N-glycosylated.	Belongs to the glycerophosphoryl diester phosphodiesterase family.	Glycerophospholipid catabolism	PE1	16
+NX_Q9NZC4	ETS homologous factor	300	34892	6.83	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.	NA	Belongs to the ETS family.	NA	PE1	11
+NX_Q9NZC7	WW domain-containing oxidoreductase	414	46677	6.71	0	Golgi apparatus;Cytoplasm;Mitochondrion;Cytosol;Nucleus	Epileptic encephalopathy, early infantile, 28;Esophageal cancer;Spinocerebellar ataxia, autosomal recessive, 12	Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.	Ubiquitinated when phosphorylated by TNK2, leading to its degradation.;Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation.	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Nuclear signaling by ERBB4;Activation of the TFAP2 (AP-2) family of transcription factors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors	PE1	16
+NX_Q9NZC9	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1	954	105938	9.15	0	Nucleus	Schimke immuno-osseous dysplasia	ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.	DNA damage-regulated phosphorylation by kinases that may include ATM, ATR and PRKDC.	Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	NA	PE1	2
+NX_Q9NZD1	G-protein coupled receptor family C group 5 member D	345	38791	4.87	7	Cell membrane	NA	NA	NA	Belongs to the G-protein coupled receptor 3 family.	NA	PE1	12
+NX_Q9NZD2	Glycolipid transfer protein	209	23850	6.91	0	Cytoplasm;Cytosol	NA	Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.	NA	Belongs to the GLTP family.	Glycosphingolipid metabolism	PE1	12
+NX_Q9NZD4	Alpha-hemoglobin-stabilizing protein	102	11840	4.9	0	Cytoplasm	NA	Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.	NA	Belongs to the AHSP family.	NA	PE1	16
+NX_Q9NZD8	Maspardin	308	34960	5.85	0	Endosome membrane;trans-Golgi network membrane;Membrane;Cytoplasmic vesicle;Cytosol	Spastic paraplegia 21, autosomal recessive	May play a role as a negative regulatory factor in CD4-dependent T-cell activation.	NA	Belongs to the AB hydrolase superfamily.	NA	PE1	15
+NX_Q9NZE8	39S ribosomal protein L35, mitochondrial	188	21514	11.29	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bL35 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	2
+NX_Q9NZF1	Placenta-specific gene 8 protein	115	12507	7.87	0	Cytosol	NA	NA	NA	Belongs to the cornifelin family.	Neutrophil degranulation	PE1	4
+NX_Q9NZG7	Ninjurin-2	142	15680	9.52	2	Membrane	NA	Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.	NA	Belongs to the ninjurin family.	NA	PE1	12
+NX_Q9NZH0	G-protein coupled receptor family C group 5 member B	403	44795	8.56	7	Cell membrane;Nucleolus;Nucleoplasm;Cytoplasmic vesicle membrane;Cytoplasmic vesicle	NA	Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.	NA	Belongs to the G-protein coupled receptor 3 family.	NA	PE1	16
+NX_Q9NZH4	Putative pituitary tumor-transforming gene 3 protein	202	22064	5.54	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the securin family.	NA	PE5	8
+NX_Q9NZH5	Securin-2	202	22302	5.98	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the securin family.	Cell cycle;Oocyte meiosis;HTLV-I infection	PE1	4
+NX_Q9NZH6	Interleukin-37	218	24126	6.09	0	Secreted;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.	Proteolytically converted to the mature form by CASP1.	Belongs to the IL-1 family.	Interleukin-18 signaling;Interleukin-37 signaling	PE1	2
+NX_Q9NZH7	Interleukin-36 beta	164	18522	9.6	0	Secreted	NA	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.	N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).	Belongs to the IL-1 family.	Interleukin-36 pathway	PE1	2
+NX_Q9NZH8	Interleukin-36 gamma	169	18721	5.06	0	Secreted	NA	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.	N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).	Belongs to the IL-1 family.	Interleukin-36 pathway	PE1	2
+NX_Q9NZI2	Kv channel-interacting protein 1	227	26817	5.1	0	Cytoplasm;Dendrite;Cell membrane	NA	Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface.	NA	Belongs to the recoverin family.	Phase 1 - inactivation of fast Na+ channels	PE1	5
+NX_Q9NZI5	Grainyhead-like protein 1 homolog	618	70113	6.26	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.;Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity).;Functions as transcription activator.	NA	Belongs to the grh/CP2 family. Grainyhead subfamily.	PPARA activates gene expression	PE1	2
+NX_Q9NZI6	Transcription factor CP2-like protein 1	479	54627	6.53	0	Nucleolus;Mitochondrion;Nucleus	NA	Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752).	NA	Belongs to the grh/CP2 family. CP2 subfamily.	NA	PE1	2
+NX_Q9NZI7	Upstream-binding protein 1	540	60491	5.92	0	Nucleoplasm;Nucleus	NA	Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.	NA	Belongs to the grh/CP2 family. CP2 subfamily.	NA	PE1	3
+NX_Q9NZI8	Insulin-like growth factor 2 mRNA-binding protein 1	577	63481	9.26	0	Cytoplasm;Dendritic spine;Perinuclear region;Growth cone;Lamellipodium;Filopodium;Cytosol;Axon;Dendrite;Nucleus	NA	RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.	Phosphorylated. Phosphorylation may impair association with ACTB mRNA and hence abolishes translational repression (By similarity).	Belongs to the RRM IMP/VICKZ family.	MAPK6/MAPK4 signaling;Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	PE1	17
+NX_Q9NZJ0	Denticleless protein homolog	730	79468	9.11	0	Nucleus membrane;Nucleolus;Chromosome;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207).	Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C). Autoubiquitinated through 'Lys-48'-polyubiquitin chains in a PCNA-independent reaction, allowing proteasomal turnover. Polyubiquitinated by SCF(FBXO11) when not phosphorylated, leading to its degradation. A tight regulation of the polyubiquitination by SCF(FBXO11) is involved in the control of different processes such as TGF-beta signaling, cell cycle progression and exit.;Phosphorylated at Thr-464 by CDK1/Cyclin-B and CDK2/Cyclin-A but not by CDK2/Cyclin-E, MAPK1 or PLK1. Phosphorylation at Thr-464 inhibits the interaction with FBXO11 and decreases upon cell cycle exit induced by TGF-beta or serum starvation.;DTL is phosphorylated by AURKB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);DTL is phosphorylated by ATR	Belongs to the WD repeat cdt2 family.	Protein modification; protein ubiquitination.;Recognition of DNA damage by PCNA-containing replication complex;Neddylation	PE1	1
+NX_Q9NZJ4	Sacsin	4579	521126	6.63	0	Cytoplasm	Spastic ataxia Charlevoix-Saguenay type	Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins.	NA	NA	NA	PE1	13
+NX_Q9NZJ5	Eukaryotic translation initiation factor 2-alpha kinase 3	1116	125216	5.27	1	Endoplasmic reticulum membrane	Wolcott-Rallison syndrome	Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.	N-glycosylated.;ADP-ribosylated by PARP16 upon ER stress, which increases kinase activity.;Oligomerization of the N-terminal ER luminal domain by ER stress promotes PERK trans-autophosphorylation of the C-terminal cytoplasmic kinase domain at multiple residues including Thr-982 on the kinase activation loop (By similarity). Autophosphorylated. Phosphorylated at Tyr-619 following endoplasmic reticulum stress, leading to activate its tyrosine-protein kinase activity. Dephosphorylated by PTPN1/TP1B, leading to inactivate its enzyme activity.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.	Protein processing in endoplasmic reticulum;Alzheimer's disease;Hepatitis C;Measles;Influenza A;Herpes simplex infection;PERK regulates gene expression	PE1	2
+NX_Q9NZJ6	Ubiquinone biosynthesis O-methyltransferase, mitochondrial	369	41054	7.1	0	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Cofactor biosynthesis; ubiquinone biosynthesis.;Ubiquinone and other terpenoid-quinone biosynthesis;Metabolic pathways;Ubiquinol biosynthesis	PE1	6
+NX_Q9NZJ7	Mitochondrial carrier homolog 1	389	41544	9.4	2	Mitochondrion inner membrane	NA	Potential mitochondrial transporter. May play a role in apoptosis.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	6
+NX_Q9NZJ9	Diphosphoinositol polyphosphate phosphohydrolase 2	180	20306	5.99	0	Cytoplasm	NA	Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.	NA	Belongs to the Nudix hydrolase family. DIPP subfamily.	Synthesis of pyrophosphates in the cytosol	PE1	12
+NX_Q9NZK5	Adenosine deaminase 2	511	58934	7.75	0	Secreted	Sneddon syndrome;Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome	Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.	NA	Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.	Surfactant metabolism;Neutrophil degranulation	PE1	22
+NX_Q9NZK7	Group IIE secretory phospholipase A2	142	15989	8.61	0	Secreted	NA	PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.	NA	Belongs to the phospholipase A2 family.	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI	PE1	1
+NX_Q9NZL3	Zinc finger protein 224	707	82280	9.01	0	Nucleoplasm;Nucleus;Nucleus membrane	NA	May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9NZL4	Hsp70-binding protein 1	359	39303	5.13	0	Cytoplasmic vesicle;Cytosol;Centrosome	NA	Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.	NA	NA	Protein processing in endoplasmic reticulum	PE1	19
+NX_Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	768	86701	5.78	0	Golgi apparatus;Nucleoplasm;Cytoplasmic vesicle	NA	Probable guanine nucleotide exchange factor.	NA	NA	PPARA activates gene expression	PE1	1
+NX_Q9NZL9	Methionine adenosyltransferase 2 subunit beta	334	37552	6.9	0	Nucleus;Cell membrane	NA	Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).	NA	Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.	Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.;Cysteine and methionine metabolism;Metabolic pathways;Methylation;Ub-specific processing proteases	PE1	5
+NX_Q9NZM1	Myoferlin	2061	234709	5.84	1	Cytoplasmic vesicle;Cytoplasmic vesicle membrane;Nucleus membrane;Cell membrane	NA	Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).	NA	Belongs to the ferlin family.	NA	PE1	10
+NX_Q9NZM3	Intersectin-2	1697	193461	8.32	0	Cytoplasmic vesicle;Cytoplasm;Cell membrane	NA	Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003).	NA	NA	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	2
+NX_Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	1560	158490	6.17	0	Nucleoplasm	NA	Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454).	NA	NA	NA	PE1	19
+NX_Q9NZM5	Ribosome biogenesis protein NOP53	478	54389	10.32	0	Nucleoplasm;Nucleolus	NA	Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1 (PubMed:27824081).	Phosphorylated upon DNA damage probably by ATM and DNA-PK; may regulate NOP53 degradation.;Ubiquitin-mediated proteasomal degradation is regulated by c-JUN. It is associated with relocalization to the nucleoplasm and decreased homooligomerization.	Belongs to the NOP53 family.	Herpes simplex infection	PE1	19
+NX_Q9NZM6	Polycystic kidney disease 2-like 2 protein	624	73790	9	6	Membrane;Cytosol;Cell membrane	NA	May function as a subunit of a cation channel and play a role in fertilization.	NA	Belongs to the polycystin family.	NA	PE1	5
+NX_Q9NZN1	Interleukin-1 receptor accessory protein-like 1	696	79969	5.87	1	Cytoplasm;Axon;Dendrite;Cell membrane	Mental retardation, X-linked 21	May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:12783849). May activate the MAP kinase JNK (PubMed:15123616). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).	NA	Belongs to the interleukin-1 receptor family.	Receptor-type tyrosine-protein phosphatases;Interleukin-38 signaling	PE1	X
+NX_Q9NZN3	EH domain-containing protein 3	535	60887	6.12	0	Cilium membrane;Recycling endosome membrane;Cell membrane	NA	ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250).	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.	Endocytosis;Factors involved in megakaryocyte development and platelet production	PE1	2
+NX_Q9NZN4	EH domain-containing protein 2	543	61161	6.03	0	Cytosol;Endosome membrane;Caveola;Cell membrane	NA	ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833).	EHD2 is phosphorylated by NEK3	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.	Endocytosis;Factors involved in megakaryocyte development and platelet production	PE1	19
+NX_Q9NZN5	Rho guanine nucleotide exchange factor 12	1544	173232	5.49	0	Cytoplasm;Cell membrane;Membrane;Nucleoplasm;Cytosol	NA	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.	NA	NA	Vascular smooth muscle contraction;Axon guidance;Regulation of actin cytoskeleton;Tuberculosis;Rho GTPase cycle;NRAGE signals death through JNK;G alpha (12/13) signalling events;Sema4D induced cell migration and growth-cone collapse	PE1	11
+NX_Q9NZN8	CCR4-NOT transcription complex subunit 2	540	59738	7.23	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.	NA	Belongs to the CNOT2/3/5 family.	RNA degradation;Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	12
+NX_Q9NZN9	Aryl-hydrocarbon-interacting protein-like 1	384	43903	5.63	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Leber congenital amaurosis 4	May be important in protein trafficking and/or protein folding and stabilization.	NA	NA	NA	PE1	17
+NX_Q9NZP0	Olfactory receptor 6C3	311	35531	8.75	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE3	12
+NX_Q9NZP2	Olfactory receptor 6C2	312	35178	8.96	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	12
+NX_Q9NZP5	Olfactory receptor 5AC2	309	35304	9.13	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	3
+NX_Q9NZP6	Nuclear pore-associated protein 1	1156	120954	8.94	0	Nucleoplasm;Nucleus inner membrane	NA	May be involved in spermatogenesis.	NA	NA	NA	PE1	15
+NX_Q9NZP8	Complement C1r subcomponent-like protein	487	53498	6.75	0	Cytosol;Secreted;Cytoskeleton	NA	Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.	NA	Belongs to the peptidase S1 family.	NA	PE1	12
+NX_Q9NZQ0	DnaJ homolog subfamily C member 27	273	30855	8.71	0	Cytosol;Nucleus	NA	GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.	NA	Belongs to the small GTPase superfamily. Rab family.	NA	PE1	2
+NX_Q9NZQ3	NCK-interacting protein with SH3 domain	722	78960	5.94	0	Nucleus;Cell membrane	NA	Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.	NA	NA	Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs	PE1	3
+NX_Q9NZQ7	Programmed cell death 1 ligand 1	290	33275	6.76	1	Early endosome membrane;Endomembrane system;Recycling endosome membrane;Cell membrane	NA	Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).;The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813417, PubMed:28813410). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity).	Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Cell adhesion molecules (CAMs);PD-1 signaling	PE1	9
+NX_Q9NZQ8	Transient receptor potential cation channel subfamily M member 5	1165	131451	6.32	6	Cell membrane	NA	Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.	NA	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM5 sub-subfamily.	Taste transduction;TRP channels	PE2	11
+NX_Q9NZQ9	Tropomodulin-4	345	39335	4.69	0	Cytoskeleton	NA	Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.	NA	Belongs to the tropomodulin family.	Striated Muscle Contraction	PE1	1
+NX_Q9NZR1	Tropomodulin-2	351	39595	5.21	0	Nucleoplasm;Nucleolus;Cytoskeleton	NA	Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).	NA	Belongs to the tropomodulin family.	Striated Muscle Contraction	PE1	15
+NX_Q9NZR2	Low-density lipoprotein receptor-related protein 1B	4599	515498	5.09	1	Membrane;Cytoplasmic vesicle	NA	Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.	NA	Belongs to the LDLR family.	NA	PE1	2
+NX_Q9NZR4	Visual system homeobox 1	365	38431	8.99	0	Nucleus	Keratoconus 1;Craniofacial anomalies and anterior segment dysgenesis syndrome	Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (PubMed:10903837). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (PubMed:10903837). Dispensable in early retinal development (By similarity).	NA	Belongs to the paired homeobox family.	NA	PE1	20
+NX_Q9NZS2	Killer cell lectin-like receptor subfamily F member 1	231	26563	8.88	1	Membrane	NA	Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	12
+NX_Q9NZS9	Bifunctional apoptosis regulator	450	52738	6.11	4	Endoplasmic reticulum membrane	NA	Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors.	NA	NA	NA	PE1	16
+NX_Q9NZT1	Calmodulin-like protein 5	146	15893	4.34	0	Cytosol;Cell membrane	NA	Binds calcium. May be involved in terminal differentiation of keratinocytes.	NA	NA	Calcium signaling pathway;Phosphatidylinositol signaling system;Oocyte meiosis;Vascular smooth muscle contraction;Long-term potentiation;Neurotrophin signaling pathway;Dopaminergic synapse;Olfactory transduction;Phototransduction;Insulin signaling pathway;GnRH signaling pathway;Melanogenesis;Salivary secretion;Gastric acid secretion;Alzheimer's disease;Pertussis;Tuberculosis;Glioma;Neutrophil degranulation	PE1	10
+NX_Q9NZT2	Opioid growth factor receptor	677	73325	4.77	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.	NA	Belongs to the opioid growth factor receptor family.	NA	PE1	20
+NX_Q9NZU0	Leucine-rich repeat transmembrane protein FLRT3	649	73004	7.55	1	Endoplasmic reticulum membrane;Cell membrane;Growth cone membrane;Cell junction;Focal adhesion;Secreted;Cytosol;Axon	Hypogonadotropic hypogonadism 21 with or without anosmia	Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).	Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.;N-glycosylated.	NA	Signaling by ROBO receptors;Downstream signaling of activated FGFR1	PE1	20
+NX_Q9NZU1	Leucine-rich repeat transmembrane protein FLRT1	646	71358	5.95	1	Endoplasmic reticulum membrane;Cell membrane;Cell junction;Focal adhesion;Secreted;Cytoplasmic vesicle membrane;Neuron projection;Perinuclear region	NA	Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.	Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain.;N-glycosylated.;Phosphorylated in response to FGFR1 signaling, but is not a direct substrate of FGFR1 or SRC. A mutant where the Tyr phosphorylation sites have been replaced by Phe displays constitutive FGFR1-dependent activation of downstream MAP kinases.	NA	Downstream signaling of activated FGFR1	PE1	11
+NX_Q9NZU5	LIM and cysteine-rich domains protein 1	365	40833	8.27	0	Cytoplasm;Cell membrane;Cell junction;Nucleoplasm;Cytosol;Nucleus	NA	Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.	NA	NA	Surfactant metabolism	PE1	3
+NX_Q9NZU7	Calcium-binding protein 1	370	39838	8.65	0	Golgi apparatus;Cell cortex;Cell membrane;Postsynaptic density;Perinuclear region;Cytoskeleton	NA	Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).	Phosphorylated. The phosphorylation regulates the activity.	NA	NA	PE1	12
+NX_Q9NZV1	Cysteine-rich motor neuron 1 protein	1036	113738	5.08	1	Secreted;Cell membrane	NA	May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.	N-glycosylated.	NA	NA	PE1	2
+NX_Q9NZV5	Selenoprotein N	590	65813	5.32	0	Cytosol;Endoplasmic reticulum membrane	Myopathy, congenital, with fiber-type disproportion;Rigid spine muscular dystrophy 1	Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290).;Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863).	N-glycosylated.	NA	NA	PE1	1
+NX_Q9NZV6	Methionine-R-sulfoxide reductase B1	116	12760	8.64	0	Cytoplasm;Nucleus;Cytoskeleton	NA	Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.	NA	Belongs to the MsrB Met sulfoxide reductase family.	Protein repair	PE1	16
+NX_Q9NZV7	Zinc finger imprinted 2	527	61164	6.3	0	Cytosol;Nucleus speckle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9NZV8	Potassium voltage-gated channel subfamily D member 2	630	70537	8.24	6	Dendritic spine;Cell membrane;Postsynaptic cell membrane;Perikaryon;Cell junction;Synapse;Dendrite	NA	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity).	Phosphorylation at Ser-438 in response to MAPK activation is increased in stimulated dendrites. Interaction with KCNIP2 and DPP6 propomtes phosphorylation by PKA at Ser-552. Phosphorylation at Ser-552 has no effect on interaction with KCNIP3, but is required for the regulation of channel activity by KCNIP3. Phosphorylation at Ser-552 leads to KCND2 internalization (By similarity). Phosphorylated by MAPK in response to signaling via the metabotropic glutamate receptor GRM5 (By similarity). Phosphorylation at Ser-616 is required for the down-regulation of neuronal A-type currents in response to signaling via GRM5 (By similarity).	Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.	Voltage gated Potassium channels;Phase 1 - inactivation of fast Na+ channels	PE1	7
+NX_Q9NZW4	Dentin sialophosphoprotein	1301	131151	3.58	0	Extracellular matrix	Dentin dysplasia 2;Deafness, autosomal dominant, 39, with dentinogenesis imperfecta 1;Dentinogenesis imperfecta, Shields type 3;Dentinogenesis imperfecta, Shields type 2	DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.	DSP is glycosylated.	NA	ECM proteoglycans	PE1	4
+NX_Q9NZW5	MAGUK p55 subfamily member 6	540	61117	5.82	0	Membrane	NA	NA	NA	Belongs to the MAGUK family.	NA	PE1	7
+NX_Q9NZY2	Putative uncharacterized protein FAM30A	134	14626	6.88	0	NA	NA	NA	NA	NA	NA	PE5	14
+NX_Q9NZZ3	Charged multivesicular body protein 5	219	24571	4.68	0	Cytosol;Cytoskeleton;Midbody;Endosome membrane	NA	Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.	ISGylated. Isgylation inhibits its interaction with VTA1.	Belongs to the SNF7 family.	Endocytosis;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT)	PE1	9
+NX_Q9P000	COMM domain-containing protein 9	198	21819	5.6	0	Golgi apparatus;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).	NA	NA	Neutrophil degranulation;Neddylation	PE1	11
+NX_Q9P003	Protein cornichon homolog 4	139	16093	6.16	3	Membrane;Endoplasmic reticulum;Endoplasmic reticulum-Golgi intermediate compartment	NA	Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).	NA	Belongs to the cornichon family.	NA	PE1	1
+NX_Q9P013	Spliceosome-associated protein CWC15 homolog	229	26624	5.55	0	Nucleus speckle;Nucleus;Mitochondrion	NA	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.	NA	Belongs to the CWC15 family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	11
+NX_Q9P015	39S ribosomal protein L15, mitochondrial	296	33420	10.02	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL15 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	8
+NX_Q9P016	Thymocyte nuclear protein 1	225	25697	9.3	0	Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.	Phosphorylated.	NA	NA	PE1	11
+NX_Q9P021	Cysteine-rich PDZ-binding protein	101	11216	9.57	0	Cytoplasm;Dendritic spine;Nucleolus;Nucleoplasm;Synapse	Short stature with microcephaly and distinctive facies	Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.	NA	Belongs to the CRIPT family.	NA	PE1	2
+NX_Q9P031	Thyroid transcription factor 1-associated protein 26	241	28670	9.89	0	Nucleoplasm;Nucleolus;Nucleus;Cell membrane	NA	Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.	NA	Belongs to the TAP26 family.	Surfactant metabolism	PE1	12
+NX_Q9P032	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4	175	20266	8.85	0	Membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 15	Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:18179882, PubMed:28853723). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.	Phosphorylated on serine. Prolactin stimulate serine phosphorylation (By similarity).	Belongs to the NDUFAF4 family.	Complex I biogenesis	PE1	6
+NX_Q9P035	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3	362	43160	9.04	6	Endoplasmic reticulum;Cytoplasm;Endoplasmic reticulum membrane;Cell membrane	NA	Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).	NA	Belongs to the very long-chain fatty acids dehydratase HACD family.	Lipid metabolism; fatty acid biosynthesis.;Synthesis of very long-chain fatty acyl-CoAs	PE1	15
+NX_Q9P055	JNK1/MAPK8-associated membrane protein	319	36169	8.18	7	Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum membrane;Cytoplasmic vesicle	NA	May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).	Ubiquitinated by RNF5 via 'Lys-63'-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD (By similarity).	NA	NA	PE1	14
+NX_Q9P086	Mediator of RNA polymerase II transcription subunit 11	117	13129	5.71	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 11 family.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	17
+NX_Q9P0B6	Coiled-coil domain-containing protein 167	97	11459	9.52	1	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	6
+NX_Q9P0G3	Kallikrein-14	267	29122	9.47	0	Extracellular space	NA	Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.	Proteolytic cleavage of the activation peptide produces the active enzyme.	Belongs to the peptidase S1 family. Kallikrein subfamily.	Formation of the cornified envelope	PE1	19
+NX_Q9P0I2	ER membrane protein complex subunit 3	261	29952	6.33	2	Membrane;Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the EMC3 family.	NA	PE1	3
+NX_Q9P0J0	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	144	16698	8.02	1	Mitochondrion inner membrane;Mitochondrion;Nucleus	Mitochondrial complex I deficiency, nuclear type 28;Hurthle cell thyroid carcinoma	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091).	NA	Belongs to the complex I NDUFA13 subunit family.	Oxidative phosphorylation;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	19
+NX_Q9P0J1	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial	537	61054	6.2	0	Nucleoplasm;Mitochondrion matrix;Mitochondrion;Cytosol	Pyruvate dehydrogenase phosphatase deficiency	Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.	NA	Belongs to the PP2C family.	Regulation of pyruvate dehydrogenase (PDH) complex	PE1	8
+NX_Q9P0J6	39S ribosomal protein L36, mitochondrial	103	11784	11.27	0	Mitochondrion;Nucleus	NA	NA	NA	Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	5
+NX_Q9P0J7	E3 ubiquitin-protein ligase KCMF1	381	41945	5.41	0	Nucleoplasm;Cytosol	NA	Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.	NA	Belongs to the KCMF1 family.	Neutrophil degranulation	PE1	2
+NX_Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	906	100433	6.91	1	Cell junction;Axon;Cell membrane	Epileptic encephalopathy, early infantile, 61	Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.	The precursor is cleaved by a furin endopeptidase.	NA	LGI-ADAM interactions	PE1	7
+NX_Q9P0K7	Ankycorbin	980	110041	5.87	0	Cell cortex;Cell junction;Nucleoplasm;Stress fiber;Cytosol;Nucleus;Cytoskeleton	NA	Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.	NA	NA	NA	PE1	5
+NX_Q9P0K8	Forkhead box protein J2	574	62395	6.2	0	Nucleoplasm;Nucleolus;Nucleus	NA	Transcriptional activator. Able to bind to two different type of DNA binding sites.;Behaves as a more potent transactivator than FOXJ2.S.	NA	NA	NA	PE1	12
+NX_Q9P0K9	DOMON domain-containing protein FRRS1L	344	37270	7.55	1	Synapse;Cell membrane	Epileptic encephalopathy, early infantile, 37	Important modulator of glutamate signaling pathway.	NA	NA	NA	PE1	9
+NX_Q9P0L0	Vesicle-associated membrane protein-associated protein A	249	27893	8.8	1	Endoplasmic reticulum membrane;Cell membrane;Nucleus membrane;Endoplasmic reticulum;Tight junction	NA	Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470).	NA	Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.	Tight junction;Sphingolipid de novo biosynthesis;Neutrophil degranulation;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	18
+NX_Q9P0L1	Zinc finger protein with KRAB and SCAN domains 7	754	85033	7.26	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	3
+NX_Q9P0L2	Serine/threonine-protein kinase MARK1	795	89003	9.42	0	Cytoplasm;Dendrite;Cell membrane;Cytoskeleton	NA	Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).	Phosphorylation at Thr-613 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity (By similarity). Phosphorylated at Thr-215 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-215 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-219 by GSK3-beta (GSK3B) inhibits the kinase activity.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	NA	PE1	1
+NX_Q9P0L9	Polycystic kidney disease 2-like 1 protein	805	91982	5.34	6	Cilium membrane;Cytoplasmic vesicle;Cell membrane	NA	Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:23212381, PubMed:30004384). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336289). The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:19812697). The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:23212381). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity).	Palmitoylation is important for expression at the cell membrane and for channel activity.	Belongs to the polycystin family.	NA	PE1	10
+NX_Q9P0M2	A-kinase anchor protein 7 isoform gamma	348	39518	5.85	0	Cytoplasmic vesicle;Cytoplasm;Nucleus	NA	Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.	NA	NA	NA	PE1	6
+NX_Q9P0M4	Interleukin-17C	197	21765	8.44	0	Secreted	NA	Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.	NA	Belongs to the IL-17 family.	Interleukin-17 signaling	PE1	16
+NX_Q9P0M6	Core histone macro-H2A.2	372	40058	9.71	0	Nucleoplasm;Nucleus;Chromosome	NA	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.	NA	NA	Systemic lupus erythematosus	PE1	10
+NX_Q9P0M9	39S ribosomal protein L27, mitochondrial	148	16073	10.42	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bL27 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	17
+NX_Q9P0N5	Transmembrane protein 216	145	16487	9.39	4	Membrane;Cilium basal body	Joubert syndrome 2;Meckel syndrome 2	Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition.	NA	NA	Anchoring of the basal body to the plasma membrane	PE1	11
+NX_Q9P0N8	E3 ubiquitin-protein ligase MARCH2	246	26995	7.46	2	Endoplasmic reticulum membrane;Endosome membrane;Lysosome membrane;Endoplasmic reticulum;Cytosol	NA	E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.	NA	NA	Protein modification; protein ubiquitination.	PE1	19
+NX_Q9P0N9	TBC1 domain family member 7	293	33972	8.08	0	Cytoplasmic vesicle	Macrocephaly/megalencephaly syndrome, autosomal recessive	Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.	NA	NA	TBC/RABGAPs	PE1	6
+NX_Q9P0P0	E3 ubiquitin-protein ligase RNF181	153	17909	4.93	0	Nucleoplasm;Cytosol	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	Auto-ubiquitinated as part of the enzymatic reaction.	Belongs to the RNF181 family.	Protein modification; protein ubiquitination.;E3 ubiquitin ligases ubiquitinate target proteins	PE1	2
+NX_Q9P0P8	Mitochondrial transcription rescue factor 1	240	27941	9.31	0	Mitochondrion matrix	NA	Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability.	NA	NA	NA	PE1	6
+NX_Q9P0R6	GSK3B-interacting protein	139	15648	4.36	0	Golgi apparatus;Cytoplasm;Nucleolus;Cytoplasmic vesicle;Nucleus	NA	A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:27484798, PubMed:25920809, PubMed:16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702).	Phosphorylated by GSK3B.	Belongs to the GSKIP family.	NA	PE1	14
+NX_Q9P0S2	Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial	106	12293	9.49	1	Cytoplasm;Mitochondrion inner membrane;Mitochondrion;Cell membrane	NA	Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:29355485, PubMed:29381136). Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (PubMed:29355485, PubMed:29381136). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6 (PubMed:29381136). Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines (PubMed:29381136).	NA	Belongs to the COX16 family.	Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	14
+NX_Q9P0S3	ORM1-like protein 1	153	17371	9.64	2	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Negative regulator of sphingolipid synthesis.	NA	Belongs to the ORM family.	Sphingolipid de novo biosynthesis	PE1	2
+NX_Q9P0S9	Transmembrane protein 14C	112	11565	9.87	4	Mitochondrion membrane	NA	Required for normal heme biosynthesis.	NA	Belongs to the TMEM14 family.	NA	PE1	6
+NX_Q9P0T4	Zinc finger protein 581	197	22010	9.16	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	19
+NX_Q9P0T7	Transmembrane protein 9	183	20574	6.21	1	Endoplasmic reticulum;Lysosome membrane;Late endosome membrane	NA	May be involved in intracellular transport.	N-glycosylated.	Belongs to the TMEM9 family.	NA	PE1	1
+NX_Q9P0U1	Mitochondrial import receptor subunit TOM7 homolog	55	6248	10.28	1	Mitochondrion outer membrane;Cytoplasm;Mitochondrion	NA	Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.	NA	Belongs to the Tom7 family.	Mitochondrial protein import;Pink/Parkin Mediated Mitophagy	PE1	7
+NX_Q9P0U3	Sentrin-specific protease 1	644	73481	8.69	0	Nucleoplasm;Cytoplasm;Focal adhesion;Nucleus	NA	Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Deconjugates SUMO1 from METTL3 (PubMed:29506078). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844).	NA	Belongs to the peptidase C48 family.	SUMO is proteolytically processed	PE1	12
+NX_Q9P0U4	CXXC-type zinc finger protein 1	656	75712	8.61	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.	May be regulated by proteolysis.	NA	XBP1(S) activates chaperone genes	PE1	18
+NX_Q9P0V3	SH3 domain-binding protein 4	963	107496	7.77	0	Clathrin-coated vesicle;Clathrin-coated pit;Nucleus	NA	May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.	Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.	NA	NA	PE1	2
+NX_Q9P0V8	SLAM family member 8	285	31670	5.8	1	Membrane	NA	May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.	NA	NA	NA	PE1	1
+NX_Q9P0V9	Septin-10	454	52593	6.35	0	Cytoplasm;Cytoskeleton;Cell membrane	NA	Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	NA	PE1	2
+NX_Q9P0W0	Interferon kappa	207	25218	8.66	0	Secreted	NA	May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.	NA	Belongs to the alpha/beta interferon family.	Cytokine-cytokine receptor interaction;RIG-I-like receptor signaling pathway;Jak-STAT signaling pathway	PE1	9
+NX_Q9P0W2	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related	317	35813	9.38	0	Nucleoplasm;Nucleus;Chromosome	NA	Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.	NA	NA	Factors involved in megakaryocyte development and platelet production;HDACs deacetylate histones	PE1	19
+NX_Q9P0W8	Spermatogenesis-associated protein 7	599	67719	5.9	0	Mitochondrion;Photoreceptor outer segment;Cilium basal body;Nucleoplasm;Cilium axoneme;Cytosol;Cytoskeleton	Leber congenital amaurosis 3;Retinitis pigmentosa autosomal recessive	Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity).	NA	NA	NA	PE1	14
+NX_Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	2223	245103	6.09	24	Membrane	NA	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity).	In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily.	MAPK signaling pathway;Calcium signaling pathway;NCAM1 interactions	PE1	22
+NX_Q9P0Z9	Peroxisomal sarcosine oxidase	390	44066	8.67	0	Peroxisome	NA	Metabolizes sarcosine, L-pipecolic acid and L-proline.	NA	Belongs to the MSOX/MTOX family.	Glycine, serine and threonine metabolism;Lysine degradation;Metabolic pathways;Peroxisome;Lysine catabolism;Peroxisomal protein import	PE1	17
+NX_Q9P104	Docking protein 5	306	35464	9.02	0	Focal adhesion	NA	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.	Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.	Belongs to the DOK family. Type B subfamily.	RET signaling	PE1	20
+NX_Q9P107	GEM-interacting protein	970	106683	5.5	0	Nucleoplasm;Cytosol;Cell membrane	NA	Stimulates, in vitro and in vivo, the GTPase activity of RhoA.	NA	NA	Rho GTPase cycle	PE1	19
+NX_Q9P109	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4	453	53052	8.48	1	Golgi apparatus;Nucleoplasm;Golgi apparatus membrane	NA	Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity.	NA	Belongs to the glycosyltransferase 14 family.	Protein modification; protein glycosylation.;Mucin type O-Glycan biosynthesis;Metabolic pathways;O-linked glycosylation of mucins	PE1	5
+NX_Q9P121	Neurotrimin	344	37971	7.98	0	Cell membrane	NA	Neural cell adhesion molecule.	NA	Belongs to the immunoglobulin superfamily. IgLON family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	11
+NX_Q9P126	C-type lectin domain family 1 member B	229	26596	8.79	1	Membrane	NA	(Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485).;(Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).;C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).	Glycosylated.;Phosphorylated on tyrosine residue in response to rhodocytin binding.	NA	GPVI-mediated activation cascade	PE1	12
+NX_Q9P127	Leucine zipper protein 4	313	35937	9.47	0	Cytoplasm;Nucleus	NA	Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA export function in cells compromised by loss of mRNA export adapters (PubMed:25662211).	NA	NA	Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	X
+NX_Q9P1A2	Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like	415	45908	4.62	0	NA	NA	May be a regulatory subunit of serine/threonine-protein phosphatase 4.	NA	NA	NA	PE5	20
+NX_Q9P1A6	Disks large-associated protein 2	1054	117620	6.42	0	Postsynaptic density;Synapse;Cell membrane	NA	May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.	NA	Belongs to the SAPAP family.	Neurexins and neuroligins	PE1	8
+NX_Q9P1C3	Putative uncharacterized protein PRO2829	46	5407	10.93	0	Secreted	NA	NA	NA	NA	NA	PE5	14
+NX_Q9P1D8	Putative uncharacterized protein PRO2289	64	6607	11.3	0	NA	NA	NA	NA	NA	NA	PE5	16
+NX_Q9P1F3	Costars family protein ABRACL	81	9056	5.86	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the costars family.	NA	PE1	6
+NX_Q9P1G2	Putative uncharacterized protein encoded by RBM12B-AS1	102	11378	8.77	0	NA	NA	NA	NA	NA	NA	PE5	8
+NX_Q9P1J3	Putative uncharacterized protein DHRS4-AS1	65	7343	6.54	0	NA	NA	NA	NA	NA	NA	PE5	14
+NX_Q9P1P4	Putative trace amine-associated receptor 3	343	39065	8.7	7	Cell membrane	NA	NA	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (s) signalling events;Amine ligand-binding receptors	PE5	6
+NX_Q9P1P5	Trace amine-associated receptor 2	351	40134	8.91	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (s) signalling events;Amine ligand-binding receptors	PE2	6
+NX_Q9P1Q0	Vacuolar protein sorting-associated protein 54	977	110589	6.1	0	trans-Golgi network;Golgi apparatus;Nucleoplasm	NA	Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061).	NA	Belongs to the VPS54 family.	Retrograde transport at the Trans-Golgi-Network	PE1	2
+NX_Q9P1Q5	Olfactory receptor 1A1	309	34565	8.96	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	17
+NX_Q9P1T7	MyoD family inhibitor domain-containing protein	246	25788	5.09	0	Golgi apparatus;Nucleoplasm;Cytoplasm;Nucleolus	NA	Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.	NA	Belongs to the MDFI family.	NA	PE1	7
+NX_Q9P1U0	DNA-directed RNA polymerase I subunit RPA12	126	13904	4.9	0	Nucleolus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.	NA	Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;NoRC negatively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Transcription Termination;B-WICH complex positively regulates rRNA expression	PE1	6
+NX_Q9P1U1	Actin-related protein 3B	418	47608	5.61	0	Cell projection;Cytoskeleton	NA	Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.	NA	Belongs to the actin family. ARP3 subfamily.	NA	PE1	7
+NX_Q9P1V8	Sterile alpha motif domain-containing protein 15	674	77151	4.43	0	Nucleoplasm;Nucleolus;Nucleus membrane	NA	NA	NA	NA	NA	PE1	14
+NX_Q9P1W3	Calcium permeable stress-gated cation channel 1	806	93317	6.59	10	Membrane;Centrosome	NA	Acts as an osmosensitive calcium-permeable cation channel.	NA	Belongs to the CSC1 (TC 1.A.17) family.	NA	PE1	14
+NX_Q9P1W8	Signal-regulatory protein gamma	387	42498	6.71	1	Membrane	NA	Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.	NA	NA	Osteoclast differentiation;Cell surface interactions at the vascular wall;Signal regulatory protein family interactions	PE1	20
+NX_Q9P1W9	Serine/threonine-protein kinase pim-2	311	34190	5.58	0	Cytosol	NA	Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.	Autophosphorylated.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.	Acute myeloid leukemia	PE1	X
+NX_Q9P1Y5	Calmodulin-regulated spectrin-associated protein 3	1249	134750	8.61	0	Cytoplasm;Adherens junction;Nucleoplasm;Centrosome;Cytoskeleton	NA	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391).	NA	Belongs to the CAMSAP1 family.	NA	PE1	19
+NX_Q9P1Y6	PHD and RING finger domain-containing protein 1	1649	178666	9.15	0	NA	NA	NA	NA	NA	NA	PE1	11
+NX_Q9P1Z0	Zinc finger and BTB domain-containing protein 4	1013	105114	8.65	0	Nucleoplasm;Cytosol;Nucleus;Chromosome	NA	Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).	Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to DNA damage.	NA	NA	PE1	17
+NX_Q9P1Z2	Calcium-binding and coiled-coil domain-containing protein 1	691	77336	4.77	0	Cytoplasm;Cytosol;Nucleus;Cytoplasmic vesicle	NA	Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.;Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).	NA	Belongs to the CALCOCO family.	NA	PE1	12
+NX_Q9P1Z3	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3	774	86032	9.75	6	Cell membrane	NA	Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.	NA	Belongs to the potassium channel HCN family.	HCN channels	PE1	1
+NX_Q9P1Z9	Coiled-coil domain-containing protein 180	1701	197344	5.75	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_Q9P202	Whirlin	907	96558	8.74	0	Cytoplasm;Photoreceptor inner segment;Growth cone;Synapse;Stereocilium	Deafness, autosomal recessive, 31;Usher syndrome 2D	Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.	NA	NA	NA	PE1	9
+NX_Q9P203	BTB/POZ domain-containing protein 7	1132	126368	6.51	0	Focal adhesion;Nucleus	NA	Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).	NA	NA	NA	PE1	14
+NX_Q9P206	Uncharacterized protein KIAA1522	1035	107095	9.75	0	Nucleoplasm;Cell junction;Cell membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q9P209	Centrosomal protein of 72 kDa	647	71718	6.08	0	Centriolar satellite;Centrosome	NA	Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).	NA	Belongs to the CEP72 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	5
+NX_Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	2302	258715	6.07	0	Golgi apparatus membrane;Cytosol;Cell membrane	Nephrotic syndrome 3	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.	NA	NA	Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Phosphatidylinositol signaling system;Synthesis of IP3 and IP4 in the cytosol	PE1	10
+NX_Q9P215	Pogo transposable element with KRAB domain	609	69444	5.06	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	1
+NX_Q9P217	Zinc finger SWIM domain-containing protein 5	1185	130634	6.78	0	Nucleus speckle	NA	NA	NA	NA	NA	PE1	1
+NX_Q9P218	Collagen alpha-1(XX) chain	1284	135830	8.27	0	Extracellular space	NA	Probable collagen protein.	NA	NA	Collagen biosynthesis and modifying enzymes;Collagen chain trimerization	PE1	20
+NX_Q9P219	Protein Daple	2028	228230	5.87	0	Nucleoplasm;Cytoplasm;Nucleolus	Spinocerebellar ataxia 40;Hydrocephalus, congenital, 1	Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway (PubMed:25062847).	NA	Belongs to the CCDC88 family.	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	PE1	14
+NX_Q9P225	Dynein heavy chain 2, axonemal	4427	507698	5.98	0	Cilium axoneme;Cytoskeleton	NA	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).	NA	Belongs to the dynein heavy chain family.	Huntington's disease	PE1	17
+NX_Q9P227	Rho GTPase-activating protein 23	1491	162192	9.31	0	Nucleoplasm;Cytosol;Cell membrane	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	NA	NA	Rho GTPase cycle	PE1	17
+NX_Q9P232	Contactin-3	1028	112883	5.94	0	Cell membrane	NA	Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity).	NA	Belongs to the immunoglobulin superfamily. Contactin family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	3
+NX_Q9P241	Probable phospholipid-transporting ATPase VD	1426	160274	6.78	10	Nucleoplasm;Endoplasmic reticulum membrane;Cell membrane	NA	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases	PE1	4
+NX_Q9P242	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2	653	70548	8.71	0	Nucleoplasm;Cytoskeleton	NA	Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.	Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.	Belongs to the NYAP family.	NA	PE1	2
+NX_Q9P243	Zinc finger protein ZFAT	1243	139034	6.9	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).	NA	NA	NA	PE1	8
+NX_Q9P244	Leucine-rich repeat and fibronectin type III domain-containing protein 1	771	82318	6.62	1	Membrane;Postsynaptic density;Synapse	NA	Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity).	Glycosylated.	Belongs to the LRFN family.	Synaptic adhesion-like molecules	PE1	19
+NX_Q9P246	Stromal interaction molecule 2	746	83971	6.3	1	Endoplasmic reticulum membrane	NA	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.	Glycosylated.;Phosphorylated predominantly on Ser residues.	NA	NA	PE1	4
+NX_Q9P253	Vacuolar protein sorting-associated protein 18 homolog	973	110186	5.72	0	Clathrin-coated vesicle;Early endosome;Lysosome membrane;Autophagosome;Late endosome membrane	NA	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity).	NA	Belongs to the VPS18 family.	NA	PE1	15
+NX_Q9P255	Zinc finger protein 492	531	61158	9.4	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q9P258	Protein RCC2	522	56085	9.02	0	Cell membrane;Nucleolus;Chromosome;Midbody;Centromere;Spindle;Nucleus;Cytoskeleton	NA	Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:23388455, PubMed:12919680, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598).	NA	NA	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	1
+NX_Q9P260	RAB11-binding protein RELCH	1216	134630	5.28	0	trans-Golgi network;Recycling endosome;Centriolar satellite;Nucleoplasm;Cytosol	NA	Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919).	NA	NA	NA	PE1	18
+NX_Q9P265	Disco-interacting protein 2 homolog B	1576	171492	8.43	0	Endoplasmic reticulum	NA	NA	NA	Belongs to the DIP2 family.	NA	PE1	12
+NX_Q9P266	Junctional protein associated with coronary artery disease	1359	148351	6.65	0	Cytoplasmic vesicle;Cell junction;Adherens junction	NA	NA	NA	NA	NA	PE1	10
+NX_Q9P267	Methyl-CpG-binding domain protein 5	1494	159895	9.17	0	Nucleoplasm;Nucleus;Midbody;Chromosome	Mental retardation, autosomal dominant 1	Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).	NA	NA	UCH proteinases	PE1	2
+NX_Q9P270	SLAIN motif-containing protein 2	581	62543	9.48	0	Cytosol;Centrosome;Cytoskeleton	NA	Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.	Is highly phosphorylated during mitosis, but not during interphase. The highly phosphorylated form does not localize at microtubule plus ends and does not interact with MAPRE1 or CKAP5.	Belongs to the SLAIN motif-containing family.	NA	PE1	4
+NX_Q9P272	Probable tRNA methyltransferase 9B	454	51299	6.2	0	Nucleoplasm;Cytosol	NA	May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.	NA	Belongs to the methyltransferase superfamily.	tRNA modification in the nucleus and cytosol	PE1	8
+NX_Q9P273	Teneurin-3	2699	300950	5.99	1	Nucleoplasm;Axon;Cell membrane	Microphthalmia, isolated, with coloboma, 9	Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes.	NA	Belongs to the tenascin family. Teneurin subfamily.	NA	PE1	4
+NX_Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	1123	122908	9.73	0	Cytoplasm;Nucleus speckle;Nucleolus	NA	Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177).	Polyubiquitinated by NEDD4L, no effect on USP36 protein levels. Both proteins interact with and regulate each other's ubiquitination levels.	Belongs to the peptidase C19 family.	NA	PE1	17
+NX_Q9P278	Folliculin-interacting protein 2	1114	122115	6.2	0	Cytoplasm;Cytosol;Centriolar satellite	NA	Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1 (PubMed:27353360). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:18403135). May regulate phosphorylation of RPS6KB1 (PubMed:18663353).	Phosphorylated by AMPK.	Belongs to the FNIP family.	NA	PE1	4
+NX_Q9P281	BAH and coiled-coil domain-containing protein 1	2639	280016	9.01	0	Nucleolus	NA	NA	NA	NA	NA	PE1	17
+NX_Q9P283	Semaphorin-5B	1151	125913	7.99	1	Membrane;Cytosol	NA	May act as positive axonal guidance cues.	NA	Belongs to the semaphorin family.	Axon guidance;O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	3
+NX_Q9P286	Serine/threonine-protein kinase PAK 5	719	80745	8.19	0	Cytoplasm;Nucleoplasm;Mitochondrion;Nucleus	NA	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.	Autophosphorylated when activated by CDC42/p21.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	ErbB signaling pathway;Axon guidance;Focal adhesion;T cell receptor signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;Activation of RAC1	PE1	20
+NX_Q9P287	BRCA2 and CDKN1A-interacting protein	314	35979	4.51	0	Centriole;Nucleoplasm;Spindle pole;Centrosome;Cytosol;Nucleus	NA	During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342).	NA	Belongs to the BCP1 family.	NA	PE1	10
+NX_Q9P289	Serine/threonine-protein kinase 26	416	46529	5.16	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Centrosome;Cytosol	NA	Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006).	STK26 is phosphorylated by TNIK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	Apoptotic cleavage of cellular proteins	PE1	X
+NX_Q9P291	Armadillo repeat-containing X-linked protein 1	453	49180	9.32	1	Mitochondrion outer membrane;Nucleoplasm;Cytosol;Mitochondrion	NA	Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.	NA	Belongs to the eutherian X-chromosome-specific Armcx family.	NA	PE1	X
+NX_Q9P296	C5a anaphylatoxin chemotactic receptor 2	337	36080	8.17	7	Cell membrane	NA	Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.	NA	Belongs to the G-protein coupled receptor 1 family.	Peptide ligand-binding receptors;Regulation of Complement cascade	PE1	19
+NX_Q9P298	HIG1 domain family member 1B	99	11058	9.55	2	Membrane	NA	NA	NA	NA	NA	PE1	17
+NX_Q9P299	Coatomer subunit zeta-2	210	23548	5.08	0	Cytoplasm;COPI-coated vesicle membrane;Endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi apparatus membrane	NA	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).	NA	Belongs to the adaptor complexes small subunit family.	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	17
+NX_Q9P2A4	ABI gene family member 3	366	39035	4.99	0	Cytoplasm	NA	May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.	NA	Belongs to the ABI family.	NA	PE1	17
+NX_Q9P2B2	Prostaglandin F2 receptor negative regulator	879	98556	6.16	1	trans-Golgi network membrane;Endoplasmic reticulum membrane	NA	Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity).	NA	NA	NA	PE1	1
+NX_Q9P2B4	CTTNBP2 N-terminal-like protein	639	70158	8.22	0	Cytosol;Stress fiber;Nucleolus;Cytoskeleton	NA	NA	NA	NA	NA	PE1	1
+NX_Q9P2B7	Cilia- and flagella-associated protein 97	532	59475	9.12	0	Nucleolus	NA	NA	NA	Belongs to the CFAP97 family.	NA	PE1	4
+NX_Q9P2C4	Transmembrane protein 181	612	69325	9.1	9	Membrane;Golgi apparatus;Cytoplasmic vesicle	NA	Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.	NA	NA	NA	PE1	6
+NX_Q9P2D0	Inhibitor of Bruton tyrosine kinase	1353	150528	7.79	0	Membrane;Nucleoplasm;Cytoplasm;Nucleus	NA	Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.	NA	NA	NA	PE1	6
+NX_Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	2997	335927	5.95	0	Nucleoplasm;Nucleus;Nucleolus	CHARGE syndrome;Hypogonadotropic hypogonadism 5 with or without anosmia;Idiopathic scoliosis 3	Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production.	NA	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	8
+NX_Q9P2D3	HEAT repeat-containing protein 5B	2071	224302	6.77	0	Nucleoplasm;Cytosol;Nucleolus	NA	NA	NA	Belongs to the HEATR5 family.	NA	PE1	2
+NX_Q9P2D6	Protein FAM135A	1515	169840	5.22	0	Nucleoplasm;Cytoplasm;Cytosol	NA	NA	NA	Belongs to the FAM135 family.	NA	PE1	6
+NX_Q9P2D7	Dynein heavy chain 1, axonemal	4265	487478	5.59	0	Cilium axoneme;Flagellum	Ciliary dyskinesia, primary, 37;Spermatogenic failure 18	Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805).	NA	Belongs to the dynein heavy chain family.	Huntington's disease	PE1	3
+NX_Q9P2D8	Protein unc-79 homolog	2635	295326	5.9	2	Membrane;Nucleoplasm;Cell membrane	NA	Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.	NA	Belongs to the unc-79 family.	Stimuli-sensing channels	PE1	14
+NX_Q9P2E2	Kinesin-like protein KIF17	1029	115068	5.38	0	Nucleoplasm;Cilium;Cytoskeleton;Cell membrane	NA	Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Intraflagellar transport;Assembly and cell surface presentation of NMDA receptors	PE1	1
+NX_Q9P2E3	NFX1-type zinc finger-containing protein 1	1918	220227	7.06	0	Mitochondrion	NA	NA	NA	NA	NA	PE1	20
+NX_Q9P2E5	Chondroitin sulfate glucuronyltransferase	772	85948	7.94	1	Golgi stack membrane;Nucleoplasm;Cytosol	NA	Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.	NA	Belongs to the chondroitin N-acetylgalactosaminyltransferase family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Metabolic pathways;Chondroitin sulfate biosynthesis	PE1	7
+NX_Q9P2E7	Protocadherin-10	1040	112936	4.74	1	Golgi apparatus;Nucleoplasm;Cytoplasmic vesicle;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein.	NA	NA	NA	PE1	4
+NX_Q9P2E8	E3 ubiquitin-protein ligase MARCH4	410	45528	8.18	2	Golgi apparatus membrane	NA	E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.	NA	NA	Protein modification; protein ubiquitination.	PE2	2
+NX_Q9P2E9	Ribosome-binding protein 1	1410	152456	8.69	1	Endoplasmic reticulum;Endoplasmic reticulum membrane	NA	Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.	NA	NA	Protein processing in endoplasmic reticulum	PE1	20
+NX_Q9P2F5	Storkhead-box protein 2	926	102671	8.67	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	NA	NA	NA	NA	PE1	4
+NX_Q9P2F6	Rho GTPase-activating protein 20	1191	132608	8.26	0	Mitochondrion	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	NA	NA	Rho GTPase cycle	PE1	11
+NX_Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	1722	190438	6.31	0	Golgi apparatus;Nucleus;Nucleus membrane	NA	NA	NA	NA	NA	PE1	1
+NX_Q9P2F9	Zinc finger protein 319	582	65547	8.75	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	16
+NX_Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	1089	122002	4.98	0	Cytosol;Cell membrane	NA	Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.	NA	Belongs to the RBR family.	NA	PE1	7
+NX_Q9P2G3	Kelch-like protein 14	628	70714	6.21	0	Cytosol;Endoplasmic reticulum membrane;Cytoskeleton	NA	NA	NA	NA	NA	PE1	18
+NX_Q9P2G4	Microtubule-associated protein 10	905	100345	6.77	0	Spindle pole;Centrosome;Midbody;Cytoskeleton	NA	Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.	NA	NA	NA	PE1	1
+NX_Q9P2G9	Kelch-like protein 8	620	68802	6.12	0	Nucleoplasm	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.	NA	NA	Protein modification; protein ubiquitination.	PE1	4
+NX_Q9P2H0	Centrosomal protein of 126 kDa	1117	125870	8.95	0	Cilium basal body;Nucleoplasm;Centrosome;Cytosol;Midbody	NA	Participates in cytokinesis (PubMed:19799413). Necessary for microtubules and mitotic spindle organization (PubMed:24867236). Involved in primary cilium formation (PubMed:24867236).	NA	NA	NA	PE1	11
+NX_Q9P2H3	Intraflagellar transport protein 80 homolog	777	88035	7.59	0	Cytoplasm;Cilium axoneme;Cilium basal body	Short-rib thoracic dysplasia 2 with or without polydactyly	Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.	NA	NA	Intraflagellar transport	PE1	3
+NX_Q9P2H5	Ubiquitin carboxyl-terminal hydrolase 35	1018	113405	5.42	0	Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the peptidase C19 family.	NA	PE1	11
+NX_Q9P2I0	Cleavage and polyadenylation specificity factor subunit 2	782	88487	4.98	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing.	NA	Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.	mRNA surveillance pathway;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	14
+NX_Q9P2J2	Protein turtle homolog A	1179	126580	6.74	1	Synapse;Cell membrane	NA	Functions in dendrite outgrowth and synapse maturation.	NA	Belongs to the immunoglobulin superfamily. Turtle family.	NA	PE1	1
+NX_Q9P2J3	Kelch-like protein 9	617	69429	5.92	0	NA	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.	NA	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	9
+NX_Q9P2J5	Leucine--tRNA ligase, cytoplasmic	1176	134466	6.95	0	Cytoplasm;Cytosol;Nucleus	Infantile liver failure syndrome 1	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation;Selenoamino acid metabolism	PE1	5
+NX_Q9P2J8	Zinc finger protein 624	865	99929	9.13	0	Cytoplasmic vesicle;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	17
+NX_Q9P2J9	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial	529	59978	5.69	0	Mitochondrion matrix;Mitochondrion	NA	Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.	NA	Belongs to the PP2C family.	Regulation of pyruvate dehydrogenase (PDH) complex	PE1	16
+NX_Q9P2K1	Coiled-coil and C2 domain-containing protein 2A	1620	186185	6.3	0	Cytoplasm;Cilium basal body	Meckel syndrome 6;Joubert syndrome 9;COACH syndrome	Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).	NA	NA	Anchoring of the basal body to the plasma membrane	PE1	4
+NX_Q9P2K2	Thioredoxin domain-containing protein 16	825	93572	5.1	0	Endoplasmic reticulum lumen;Mitochondrion;Secreted	NA	NA	Glycosylated.	NA	NA	PE1	14
+NX_Q9P2K3	REST corepressor 3	495	55581	8.26	0	Nucleoplasm;Cytosol;Nucleus	NA	May act as a component of a corepressor complex that represses transcription.	NA	Belongs to the CoREST family.	NA	PE1	1
+NX_Q9P2K5	Myelin expression factor 2	600	64122	8.86	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity).	NA	NA	NA	PE1	15
+NX_Q9P2K6	Kelch-like protein 42	505	56868	5.52	0	Cytoplasm;Spindle	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	12
+NX_Q9P2K8	eIF-2-alpha kinase GCN2	1649	186911	5.88	0	Cytoplasm;Cytosol	Pulmonary venoocclusive disease 2, autosomal recessive	(Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610).;Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory. Plays a role in neurite outgrowth inhibition. Plays a proapoptotic role in response to glucose deprivation. Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity).	Autophosphorylated; autophosphorylation on Thr-899 is increased upon amino acid starvation and in UV irradiation cells and inhibited in presence of IMPACT.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.	Protein processing in endoplasmic reticulum;Hepatitis C;Measles;Influenza A;Herpes simplex infection	PE1	15
+NX_Q9P2K9	Protein dispatched homolog 3	1392	153048	7.5	12	Endoplasmic reticulum membrane;Nucleus membrane;Cytoplasmic vesicle membrane;Nucleoplasm;Cytosol	NA	Plays a role in neuronal proliferation and differentiation (PubMed:25281927). Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation (PubMed:25281927). May contribute to cholesterol homeostasis in neuronal cells (By similarity).	NA	Belongs to the patched family.	NA	PE1	1
+NX_Q9P2L0	WD repeat-containing protein 35	1181	133547	5.98	0	Centrosome;Cilium axoneme;Cilium basal body	Short-rib thoracic dysplasia 7 with or without polydactyly;Cranioectodermal dysplasia 2;Short-rib thoracic dysplasia 7/20 with polydactyly, digenic	As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (PubMed:21473986, PubMed:28400947, PubMed:29220510). May promote CASP3 activation and TNF-stimulated apoptosis.	NA	NA	Intraflagellar transport;Hedgehog 'off' state	PE1	2
+NX_Q9P2M1	LRP2-binding protein	347	39780	7.99	0	Cytoplasm	NA	May act as an adapter that regulates LRP2 function.	NA	NA	NA	PE1	4
+NX_Q9P2M4	TBC1 domain family member 14	693	78137	6.57	0	trans-Golgi network;Golgi apparatus;Nucleoplasm;cis-Golgi network;Cytoplasmic vesicle	NA	Plays a role in the regulation of starvation-induced autophagosome formation (PubMed:22613832). Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy.	NA	NA	TBC/RABGAPs	PE1	4
+NX_Q9P2M7	Cingulin	1197	136386	5.46	0	Tight junction;Cell junction;Cell membrane	NA	Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.	NA	Belongs to the cingulin family.	Tight junction;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	PE1	1
+NX_Q9P2N2	Rho GTPase-activating protein 28	729	82060	7.62	0	Cell junction	NA	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.	NA	NA	Rho GTPase cycle	PE1	18
+NX_Q9P2N4	A disintegrin and metalloproteinase with thrombospondin motifs 9	1935	216491	8.13	0	Endoplasmic reticulum;Extracellular matrix;Cytoplasmic vesicle	NA	Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.	The precursor is cleaved by a furin endopeptidase.;N-glycosylated (PubMed:12514189). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	Degradation of the extracellular matrix;O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	3
+NX_Q9P2N5	RNA-binding protein 27	1060	118718	9.24	0	Cytoplasm;Nucleus speckle	NA	NA	NA	NA	NA	PE1	5
+NX_Q9P2N6	KAT8 regulatory NSL complex subunit 3	904	95992	9.46	0	Nucleoplasm;Nucleus	NA	As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.	NA	NA	HATs acetylate histones	PE1	2
+NX_Q9P2N7	Kelch-like protein 13	655	73868	6.17	0	NA	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.	NA	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	X
+NX_Q9P2P1	Protein NYNRIN	1898	208366	8.27	2	Membrane;Cytoplasmic vesicle;Nucleoplasm;Golgi apparatus	NA	NA	NA	NA	NA	PE1	14
+NX_Q9P2P5	E3 ubiquitin-protein ligase HECW2	1572	175769	5.26	0	Cytoplasm;Spindle	Neurodevelopmental disorder with hypotonia, seizures, and absent language	E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370).	Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	2
+NX_Q9P2P6	StAR-related lipid transfer protein 9	4700	516343	5.91	0	Nucleus;Centriole	NA	Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	NA	PE1	15
+NX_Q9P2Q2	FERM domain-containing protein 4A	1039	115458	8.98	0	Golgi apparatus;Adherens junction;Nucleoplasm;Tight junction;Cytoskeleton	Agenesis of the corpus callosum, with facial anomalies and cerebellar ataxia	Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754).	NA	NA	NA	PE1	10
+NX_Q9P2R3	Rabankyrin-5	1169	128399	5.7	0	Cytoplasm;Early endosome;Endosome;Endosome membrane	NA	Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.	NA	NA	NA	PE1	17
+NX_Q9P2R6	Arginine-glutamic acid dipeptide repeats protein	1566	172424	7.44	0	Nucleus	Neurodevelopmental disorder with or without anomalies of the brain, eye, or heart	Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.	NA	NA	NA	PE1	1
+NX_Q9P2R7	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	463	50317	7.05	0	Mitochondrion	Mitochondrial DNA depletion syndrome 5	ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity).	NA	Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.	Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.;Citrate cycle (TCA cycle);Propanoate metabolism;Metabolic pathways;Citric acid cycle (TCA cycle)	PE1	13
+NX_Q9P2S2	Neurexin-2	1712	184982	5.61	1	Membrane	NA	Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.	NA	Belongs to the neurexin family.	Cell adhesion molecules (CAMs);Neurexins and neuroligins	PE1	11
+NX_Q9P2S5	WD repeat-containing protein WRAP73	460	51588	6.37	0	Cytoplasm;Centrosome;Centriolar satellite;Centriole	NA	The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238).	NA	NA	NA	PE1	1
+NX_Q9P2S6	Ankyrin repeat and MYND domain-containing protein 1	941	105516	6.28	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	2
+NX_Q9P2T0	Testicular haploid expressed gene protein	379	43444	9.17	0	Nucleus	NA	May be involved (but not essential) in spermatogenesis.	NA	NA	NA	PE1	19
+NX_Q9P2T1	GMP reductase 2	348	37874	6.8	0	Nucleoplasm;Nucleolus	NA	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).	NA	Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.	Purine metabolism;Purine salvage	PE1	14
+NX_Q9P2U7	Vesicular glutamate transporter 1	560	61613	7.2	12	Membrane;Synaptic vesicle membrane;Synaptosome	NA	Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.	NA	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.	Synaptic vesicle cycle;Glutamatergic synapse;Organic anion transporters;Glutamate Neurotransmitter Release Cycle	PE1	19
+NX_Q9P2U8	Vesicular glutamate transporter 2	582	64392	6.62	12	Membrane;Synaptic vesicle membrane;Synaptosome	NA	Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.	NA	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.	Synaptic vesicle cycle;Glutamatergic synapse;Organic anion transporters	PE1	11
+NX_Q9P2V4	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1	623	68041	8.9	1	Endoplasmic reticulum membrane	NA	Possible role in phototransduction.	NA	NA	NA	PE1	10
+NX_Q9P2W1	Homologous-pairing protein 2 homolog	217	24906	7.62	0	Nucleoplasm;Nucleus	Ovarian dysgenesis 3	Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.	PTM: Phosphorylated by PKA, PKC and MAPK.	Belongs to the HOP2 family.	Meiotic recombination	PE1	17
+NX_Q9P2W3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	67	7949	5.05	0	Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the G protein gamma family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Taste transduction;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	16
+NX_Q9P2W6	Uncharacterized protein C11orf21	132	14447	9.55	0	Nucleoplasm;Cytosol;Cytoplasm	NA	NA	NA	NA	NA	PE2	11
+NX_Q9P2W7	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	334	38256	9.64	1	Cytoplasmic vesicle;Endoplasmic reticulum membrane;Secreted;Golgi apparatus membrane	NA	Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.	The soluble form derives from the membrane form by proteolytic processing.	Belongs to the glycosyltransferase 43 family.	Protein modification; protein glycosylation.;Glycosaminoglycan biosynthesis - chondroitin sulfate;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;A tetrasaccharide linker sequence is required for GAG synthesis	PE1	11
+NX_Q9P2W9	Syntaxin-18	335	38674	5.36	1	Endoplasmic reticulum membrane;Cell membrane;Golgi apparatus membrane	NA	Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.	NA	Belongs to the syntaxin family.	SNARE interactions in vesicular transport;Phagosome;COPI-dependent Golgi-to-ER retrograde traffic	PE1	4
+NX_Q9P2X0	Dolichol-phosphate mannosyltransferase subunit 3	92	10094	5.66	2	Endoplasmic reticulum membrane	Muscular dystrophy-dystroglycanopathy limb-girdle C15	Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER.	NA	Belongs to the DPM3 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Synthesis of dolichyl-phosphate mannose;Defective DPM2 causes DPM2-CDG (CDG-1u);Defective DPM1 causes DPM1-CDG (CDG-1e);Defective DPM3 causes DPM3-CDG (CDG-1o)	PE1	1
+NX_Q9P2X3	Protein IMPACT	320	36476	4.86	0	Cytoplasm;Nucleoplasm	NA	Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.	NA	Belongs to the IMPACT family.	NA	PE1	18
+NX_Q9P2X7	Deleted in esophageal cancer 1	70	7542	7.93	0	NA	NA	Candidate tumor suppressor.	NA	NA	NA	PE2	9
+NX_Q9P2X8	Putative uncharacterized protein encoded by LINC00474	69	7854	7.77	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_Q9P2Y4	Zinc finger protein 219	722	76877	9.56	0	Nucleoplasm;Nucleus	NA	Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	14
+NX_Q9P2Y5	UV radiation resistance-associated gene protein	699	78151	8.56	0	Early endosome;Endoplasmic reticulum;Centromere;Autophagosome;Late endosome;Lysosome;Midbody	NA	Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840).;Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300).	Phosphorylated at Ser-498 by MTOR under basal conditions; increases the interaction with RUBCN implicated in inhibitory effect of RUBCN on PI3KC3 and decreases interaction with RAB7,A and VPS16 and VPS39 (indicative for a class C Vps complex, possibly the HOPS complex) (PubMed:25533187).	NA	Macroautophagy	PE1	11
+NX_Q9P2Z0	THAP domain-containing protein 10	257	28351	8.95	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	15
+NX_Q9QC07	Endogenous retrovirus group K member 18 Pol protein	812	91948	9.21	0	NA	NA	Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	NA	Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.	NA	PE3	1
+NX_Q9TQE0	HLA class II histocompatibility antigen, DRB1-9 beta chain	266	29826	7.67	1	Endoplasmic reticulum membrane;Endosome membrane;Cell membrane;Lysosome membrane;trans-Golgi network membrane;Late endosome membrane	NA	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.	Belongs to the MHC class II family.	MHC class II antigen presentation;Interferon gamma signaling;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PD-1 signaling	PE1	6
+NX_Q9UBB4	Ataxin-10	475	53489	5.12	0	Cytoplasm;Cytosol;Perinuclear region;Cell membrane	Spinocerebellar ataxia 10	Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.	NA	Belongs to the ataxin-10 family.	NA	PE1	22
+NX_Q9UBB5	Methyl-CpG-binding domain protein 2	411	43255	10.06	0	Nucleoplasm;Nucleus	NA	Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.	NA	NA	NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Opening	PE1	18
+NX_Q9UBB6	Neurochondrin	729	78864	5.34	0	Cytosol;Dendrite	NA	Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.	NA	Belongs to the neurochondrin family.	NA	PE1	1
+NX_Q9UBB9	Tuftelin-interacting protein 11	837	96820	5.45	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.	NA	Belongs to the TFP11/STIP family.	mRNA Splicing - Major Pathway	PE1	22
+NX_Q9UBC0	Hepatocyte nuclear factor 6	465	51023	9.71	0	Nucleus	NA	Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.	NA	Belongs to the CUT homeobox family.	Maturity onset diabetes of the young;Regulation of gene expression in early pancreatic precursor cells;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	PE1	15
+NX_Q9UBC1	NF-kappa-B inhibitor-like protein 1	381	43204	6.86	0	Nucleoplasm;Nucleus	Rheumatoid arthritis	Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.	NA	NA	NA	PE1	6
+NX_Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	864	94255	4.93	0	Cytoplasmic vesicle;Coated pit;Nucleus;Cell membrane	NA	Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.	Phosphorylated on tyrosine residues by EGFR.	NA	EGFR downregulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	19
+NX_Q9UBC3	DNA (cytosine-5)-methyltransferase 3B	853	95751	8.74	0	Nucleoplasm;Nucleus	Facioscapulohumeral muscular dystrophy 2;Immunodeficiency-centromeric instability-facial anomalies syndrome 1	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398).	Citrullinated by PADI4.;Sumoylated.	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Cysteine and methionine metabolism;Metabolic pathways;NoRC negatively regulates rRNA expression;PRC2 methylates histones and DNA;DNA methylation;SUMOylation of DNA methylation proteins	PE1	20
+NX_Q9UBC5	Unconventional myosin-Ia	1043	118401	9.37	0	Nucleoplasm	NA	Involved in directing the movement of organelles along actin filaments.	Phosphorylated by ALPK1.	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	12
+NX_Q9UBC7	Galanin-like peptide	116	12545	5.86	0	Secreted	NA	Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.;Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644).	NA	Belongs to the galanin family.	NA	PE2	19
+NX_Q9UBC9	Small proline-rich protein 3	169	18154	8.86	0	Cytoplasm	NA	Cross-linked envelope protein of keratinocytes.	NA	Belongs to the cornifin (SPRR) family.	Formation of the cornified envelope	PE1	1
+NX_Q9UBD0	Heat shock transcription factor, X-linked	423	46742	6.63	0	Cytoplasm;Nucleus	NA	NA	NA	Belongs to the HSF family.	NA	PE1	X
+NX_Q9UBD3	Cytokine SCM-1 beta	114	12567	10.62	0	Secreted	NA	Chemotactic activity for lymphocytes but not for monocytes or neutrophils.	NA	Belongs to the intercrine gamma family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;G alpha (q) signalling events;Chemokine receptors bind chemokines	PE1	1
+NX_Q9UBD5	Origin recognition complex subunit 3	711	82254	7.54	0	Cytoplasm;Nucleoplasm;Nucleus;Chromosome	NA	Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.	Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle.	Belongs to the ORC3 family.	Cell cycle;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;Activation of ATR in response to replication stress;CDC6 association with the ORC:origin complex;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;E2F-enabled inhibition of pre-replication complex formation;Assembly of the ORC complex at the origin of replication	PE1	6
+NX_Q9UBD6	Ammonium transporter Rh type C	479	53179	5.93	12	Apical cell membrane	NA	Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.	N-glycosylated.	Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.	Rhesus glycoproteins mediate ammonium transport	PE1	15
+NX_Q9UBD9	Cardiotrophin-like cytokine factor 1	225	25176	8.68	0	Cytoplasmic vesicle;Secreted;Nucleus	Crisponi/Cold-induced sweating syndrome 2	In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.	NA	Belongs to the IL-6 superfamily.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;IL-6-type cytokine receptor ligand interactions	PE1	11
+NX_Q9UBE0	SUMO-activating enzyme subunit 1	346	38450	5.17	0	Nucleus	NA	The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.	NA	Belongs to the ubiquitin-activating E1 family.	Protein modification; protein sumoylation.;Ubiquitin mediated proteolysis;SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9)	PE1	19
+NX_Q9UBE8	Serine/threonine-protein kinase NLK	527	58283	8.35	0	Cytoplasm;Cell junction;Nucleolus;Nucleoplasm;Nucleus	NA	Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613).	Phosphorylated on Thr-298. Intermolecular autophosphorylation on Thr-298 activates the enzyme.;NLK is phosphorylated by HIPK2	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.	MAPK signaling pathway;Wnt signaling pathway;Adherens junction;Ca2+ pathway	PE1	17
+NX_Q9UBF1	Melanoma-associated antigen C2	373	41163	4.26	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.	NA	NA	NA	PE1	X
+NX_Q9UBF2	Coatomer subunit gamma-2	871	97622	5.56	0	COPI-coated vesicle membrane;Cytosol;Golgi apparatus membrane	NA	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).	NA	Belongs to the COPG family.	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	7
+NX_Q9UBF6	RING-box protein 2	113	12683	5.24	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.	Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.	Belongs to the RING-box family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	3
+NX_Q9UBF8	Phosphatidylinositol 4-kinase beta	816	91379	5.86	0	Mitochondrion outer membrane;Golgi apparatus;Endomembrane system;Rough endoplasmic reticulum membrane;Golgi apparatus membrane;Perinuclear region	NA	Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).;(Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:27989622, PubMed:22258260). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622).	NA	Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.	Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Synthesis of PIPs at the Golgi membrane	PE1	1
+NX_Q9UBF9	Myotilin	498	55395	9.18	0	Z line;Sarcolemma;Cytoskeleton	Myopathy, myofibrillar, 3;Spheroid body myopathy	Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells.	NA	Belongs to the myotilin/palladin family.	NA	PE1	5
+NX_Q9UBG0	C-type mannose receptor 2	1479	166674	5.54	1	Membrane	NA	May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).	N-glycosylated.	NA	Phagosome;Tuberculosis;Cross-presentation of soluble exogenous antigens (endosomes)	PE1	17
+NX_Q9UBG3	Cornulin	495	53533	5.73	0	Cytoplasm	NA	Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.	NA	Belongs to the S100-fused protein family.	NA	PE1	1
+NX_Q9UBG7	Recombining binding protein suppressor of hairless-like protein	517	56751	7.86	0	Nucleus	NA	Putative transcription factor, which cooperates with EBNA2 to activate transcription.	NA	Belongs to the Su(H) family.	Notch signaling pathway	PE2	20
+NX_Q9UBH0	Interleukin-36 receptor antagonist protein	155	16962	5.12	0	Secreted	Psoriasis 14, pustular	Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.	NA	Belongs to the IL-1 family.	Interleukin-36 pathway	PE1	2
+NX_Q9UBH6	Xenotropic and polytropic retrovirus receptor 1	696	81535	8.68	8	Cell membrane	Basal ganglia calcification, idiopathic, 6	Plays a role in phosphate homeostasis. Mediates phosphate export from the cell (PubMed:23791524, PubMed:25938945). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106).	NA	Belongs to the SYG1 (TC 2.A.94) family.	NA	PE1	1
+NX_Q9UBI1	COMM domain-containing protein 3	195	22151	5.62	0	Cytoplasm;Nucleus	NA	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).	NA	NA	Neutrophil degranulation;Neddylation	PE1	10
+NX_Q9UBI4	Stomatin-like protein 1	398	42968	8.18	1	Cell membrane;Membrane;Cytoplasmic vesicle;Cytosol;Membrane raft;Late endosome membrane	NA	May play a role in cholesterol transfer to late endosomes (PubMed:19696025). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation (PubMed:23082202).	NA	Belongs to the band 7/mec-2 family.	NA	PE1	15
+NX_Q9UBI6	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	72	8006	9.14	0	Mitochondrion;Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the G protein gamma family.	MAPK signaling pathway;Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;Regulation of actin cytoskeleton;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	1
+NX_Q9UBI9	Headcase protein homolog	543	58837	8.89	0	NA	NA	May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.	NA	NA	NA	PE1	6
+NX_Q9UBJ2	ATP-binding cassette sub-family D member 2	740	83233	9.04	4	Peroxisome membrane	NA	Probable transporter.	NA	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.	ABC transporters;Peroxisome;ABC transporters in lipid homeostasis;Class I peroxisomal membrane protein import	PE1	12
+NX_Q9UBK2	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	798	91027	5.71	0	Nucleus;Cytoplasm;Nucleoplasm;PML body	NA	Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.	Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.;Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.;Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.;PPARGC1A is phosphorylated by CLK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Insulin signaling pathway;Adipocytokine signaling pathway;Huntington's disease;PPARA activates gene expression;Circadian Clock;Transcriptional activation of mitochondrial biogenesis;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Transcriptional regulation of white adipocyte differentiation;Regulation of RUNX2 expression and activity;SUMOylation of transcription cofactors;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PE1	4
+NX_Q9UBK5	Hematopoietic cell signal transducer	93	9489	8.63	1	Cytoplasm;Cell membrane;Centriolar satellite;Membrane;Cytoplasmic vesicle	NA	Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells.	O-glycosylated.;Phosphorylated; PIK3R1 and GRB2 associate specifically with tyrosine-phosphorylated HCST.	Belongs to the DAP10 family.	Natural killer cell mediated cytotoxicity;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q9UBK7	Rab-like protein 2A	228	26115	4.75	0	NA	NA	Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.	NA	Belongs to the small GTPase superfamily. Rab family.	NA	PE1	2
+NX_Q9UBK8	Methionine synthase reductase	698	77674	6.04	0	Nucleoplasm;Cytoplasm;Cytosol;Cytoskeleton	Homocystinuria-megaloblastic anemia, cblE complementation type;Neural tube defects, folate-sensitive	Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects.	NA	NA	Methylation;Sulfur amino acid metabolism;Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE;Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	PE1	5
+NX_Q9UBK9	Protein UXT	157	18246	7.02	0	Cytoplasm;Centriolar satellite;Nucleoplasm;Spindle pole;Centrosome;Nucleus	NA	Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP.;Involved in gene transcription regulation (PubMed:28106301, PubMed:21730289). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584).	NA	Belongs to the UXT family.	Transcriptional Regulation by E2F6	PE1	X
+NX_Q9UBL0	cAMP-regulated phosphoprotein 21	812	89196	6.51	0	Cytoplasm;Cytosol;Nucleolus	NA	May act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.	Is methylated by CARM1 in immature thymocytes.;Phosphorylation at Ser-56 favors interaction with CALM1.	NA	NA	PE1	3
+NX_Q9UBL3	Set1/Ash2 histone methyltransferase complex subunit ASH2	628	68723	5.45	0	Nucleoplasm;Nucleus;Cell membrane	NA	Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.	Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels.	NA	PKMTs methylate histone lysines;Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	8
+NX_Q9UBL6	Copine-7	633	70294	5.97	0	Cytoplasm;Nucleus;Cell membrane	NA	Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.	NA	Belongs to the copine family.	Glycerophospholipid biosynthesis	PE1	16
+NX_Q9UBL9	P2X purinoceptor 2	471	51754	8.4	2	Cell membrane	Deafness, autosomal dominant, 41	Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.	NA	Belongs to the P2X receptor family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;Elevation of cytosolic Ca2+ levels;Platelet homeostasis	PE1	12
+NX_Q9UBM1	Phosphatidylethanolamine N-methyltransferase	199	22134	8.89	3	Mitochondrion membrane;Cytosol;Endoplasmic reticulum membrane	NA	Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC).	Is N-glycosylated with high-mannose oligosaccharides.	Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.	Phospholipid metabolism; phosphatidylcholine biosynthesis.;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PC	PE1	17
+NX_Q9UBM4	Opticin	332	37261	5.39	0	Extracellular matrix	NA	Binds collagen fibrils.	O-glycosylated.	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.	Degradation of the extracellular matrix	PE1	1
+NX_Q9UBM7	7-dehydrocholesterol reductase	475	54489	8.95	7	Endoplasmic reticulum;Cytosol;Endoplasmic reticulum membrane	Smith-Lemli-Opitz syndrome	Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).	NA	Belongs to the ERG4/ERG24 family.	Steroid biosynthesis; cholesterol biosynthesis.;Steroid biosynthesis;Metabolic pathways;Activation of gene expression by SREBF (SREBP);Cholesterol biosynthesis via desmosterol;Cholesterol biosynthesis via lathosterol	PE1	11
+NX_Q9UBM8	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C	478	56061	8.28	1	Golgi apparatus membrane	NA	Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity).	NA	Belongs to the glycosyltransferase 54 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;N-Glycan antennae elongation	PE2	12
+NX_Q9UBN1	Voltage-dependent calcium channel gamma-4 subunit	327	36579	9.23	4	Cytosol;Cell membrane	NA	Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:21172611).	NA	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Presynaptic depolarization and calcium channel opening;Trafficking of AMPA receptors;LGI-ADAM interactions;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	17
+NX_Q9UBN4	Short transient receptor potential channel 4	977	112101	7.81	6	Membrane;Cell membrane	NA	Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.	Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF.	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.	TRP channels;Role of second messengers in netrin-1 signaling	PE1	13
+NX_Q9UBN6	Tumor necrosis factor receptor superfamily member 10D	386	41823	6.19	1	Membrane;Cytoskeleton;Cell membrane	NA	Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.	NA	NA	Cytokine-cytokine receptor interaction;Apoptosis;Natural killer cell mediated cytotoxicity;Measles;Influenza A;Cell surface interactions at the vascular wall;TRAIL signaling;TP53 Regulates Transcription of Death Receptors and Ligands	PE1	8
+NX_Q9UBN7	Histone deacetylase 6	1215	131419	5.14	0	Cytoplasm;Perikaryon;Nucleoplasm;Axon;Dendrite;Nucleus	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.;Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.	Sumoylated in vitro.;Ubiquitinated. Its polyubiquitination however does not lead to its degradation.;Phosphorylated by AURKA.;HDAC6 is phosphorylated by AURKA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the histone deacetylase family. HD type 2 subfamily.	Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HSF1 activation;Cilium Assembly;Transcriptional regulation by RUNX2;RUNX2 regulates osteoblast differentiation	PE1	X
+NX_Q9UBP0	Spastin	616	67197	9.67	0	Cytoplasm;Endoplasmic reticulum membrane;Lipid droplet;Nucleus membrane;Membrane;Midbody;Endosome;Endoplasmic reticulum;Centrosome;Nucleoplasm;Cytosol;Spindle;Perinuclear region;Nucleus;Cytoskeleton	Spastic paraplegia 4, autosomal dominant	Involved in lipid metabolism by regulating the size and distribution of lipid droplets.;ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377).	NA	Belongs to the AAA ATPase family. Spastin subfamily.	NA	PE1	2
+NX_Q9UBP4	Dickkopf-related protein 3	350	38390	4.59	0	Cytoplasmic vesicle;Cytosol;Secreted;Nucleus	NA	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).	N- and O-glycosylated.	Belongs to the dickkopf family.	NA	PE1	11
+NX_Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	337	35808	8.31	0	Cytosol;Nucleus	NA	Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.	NA	Belongs to the HEY family.	NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;RUNX2 regulates osteoblast differentiation;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE1	6
+NX_Q9UBP6	tRNA (guanine-N(7)-)-methyltransferase	276	31471	7.19	0	Nucleoplasm;Nucleus	NA	Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:31031084). Internal N(7)-methylguanine methylation of mRNAs regulates translation (PubMed:31031084). Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083). Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity).	Phosphorylation at Ser-27 inactivates its catalytic activity but does not affect the interaction with WDR4.	Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	tRNA modification; N(7)-methylguanine-tRNA biosynthesis.;tRNA modification in the nucleus and cytosol	PE1	12
+NX_Q9UBP8	Kidney-associated antigen 1	84	8969	9.51	0	NA	NA	NA	NA	NA	NA	PE2	6
+NX_Q9UBP9	PTB domain-containing engulfment adapter protein 1	304	34490	8.04	0	Cytoplasm;Cytoplasmic vesicle	NA	May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.	NA	Belongs to the ced-6 family.	NA	PE1	2
+NX_Q9UBQ0	Vacuolar protein sorting-associated protein 29	182	20506	6.29	0	Cytoplasm;Endosome membrane;Early endosome;Membrane;Endosome;Late endosome;Lysosome;Cytoplasmic vesicle;Cytosol	NA	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922, PubMed:21725319, PubMed:23563491). Acts also as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (PubMed:24856514).;(Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus.	NA	Belongs to the VPS29 family.	WNT ligand biogenesis and trafficking	PE1	12
+NX_Q9UBQ5	Eukaryotic translation initiation factor 3 subunit K	218	25060	4.81	0	Cytoplasm;Cytosol;Nucleus	NA	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).	NA	Belongs to the eIF-3 subunit K family.	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	19
+NX_Q9UBQ6	Exostosin-like 2	330	37466	9.08	1	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane;Secreted	NA	Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.	The soluble form derives from the membrane form by proteolytic processing.	Belongs to the glycosyltransferase 47 family.	Glycan metabolism; heparan sulfate biosynthesis.;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;XBP1(S) activates chaperone genes	PE1	1
+NX_Q9UBQ7	Glyoxylate reductase/hydroxypyruvate reductase	328	35668	7.01	0	Nucleoplasm;Cytosol	Hyperoxaluria primary 2	Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.	NA	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Pyruvate metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Glyoxylate metabolism and glycine degradation	PE1	9
+NX_Q9UBR1	Beta-ureidopropionase	384	43166	6.09	0	Cytoplasm	Beta-ureidopropionase deficiency	Catalyzes a late step in pyrimidine degradation (PubMed:22525402, PubMed:24526388). Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide (PubMed:10542323, PubMed:11508704, PubMed:10415095, PubMed:29976570, PubMed:22525402, PubMed:24526388). Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable).	NA	Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.	Amino-acid biosynthesis; beta-alanine biosynthesis.;Pyrimidine metabolism;beta-Alanine metabolism;Pantothenate and CoA biosynthesis;Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine catabolism	PE1	22
+NX_Q9UBR2	Cathepsin Z	303	33868	6.7	0	Cytoplasmic vesicle;Endoplasmic reticulum;Lysosome	NA	Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity).	NA	Belongs to the peptidase C1 family.	Lysosome;Lysosome Vesicle Biogenesis;Metabolism of Angiotensinogen to Angiotensins;COPII-mediated vesicle transport;Cargo concentration in the ER;Neutrophil degranulation	PE1	20
+NX_Q9UBR4	LIM/homeobox protein Lhx3	397	43358	8.47	0	Nucleus	Pituitary hormone deficiency, combined, 3	Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.	NA	NA	Regulation of expression of SLITs and ROBOs	PE1	9
+NX_Q9UBR5	Chemokine-like factor	152	17170	9.41	3	Membrane;Cytoplasmic vesicle;Secreted	NA	Has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713).;May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.	NA	Belongs to the chemokine-like factor family.	NA	PE1	16
+NX_Q9UBS0	Ribosomal protein S6 kinase beta-2	482	53455	6.91	0	Cytoplasm;Cytosol;Nucleus	NA	Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).	Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	ErbB signaling pathway;mTOR signaling pathway;TGF-beta signaling pathway;Fc gamma R-mediated phagocytosis;Insulin signaling pathway;Acute myeloid leukemia;AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer	PE1	11
+NX_Q9UBS3	DnaJ homolog subfamily B member 9	223	25518	8.37	0	Endoplasmic reticulum;Cytosol;Endoplasmic reticulum lumen	NA	Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity).	NA	NA	XBP1(S) activates chaperone genes	PE1	7
+NX_Q9UBS4	DnaJ homolog subfamily B member 11	358	40514	5.81	0	Endoplasmic reticulum;Endoplasmic reticulum lumen	Polycystic kidney disease 6 with or without polycystic liver disease	As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351).	Contains high-mannose Endo H-sensitive carbohydrates.;Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys is not known.;Thr-188 was reported to be phosphorylated upon DNA damage by ATM or ATR; however as this position has been shown to be in the ER lumen, the in vivo relevance is not proven.	NA	Protein processing in endoplasmic reticulum;XBP1(S) activates chaperone genes	PE1	3
+NX_Q9UBS5	Gamma-aminobutyric acid type B receptor subunit 1	961	108320	8.49	7	Cell membrane;Postsynaptic cell membrane;Secreted;Centrosome;Dendrite	NA	May regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.;Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9844003, PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:9844003, PubMed:9872316, PubMed:24305054).	NA	Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors);Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;GABA B receptor activation	PE1	6
+NX_Q9UBS8	E3 ubiquitin-protein ligase RNF14	474	53837	4.66	0	Cytoplasm;Cytosol;Nucleus	NA	Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.	RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination.	Belongs to the RBR family. RNF14 subfamily.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	5
+NX_Q9UBS9	SUN domain-containing ossification factor	1254	139430	4.93	1	Cytosol;Rough endoplasmic reticulum membrane;Nucleolus	NA	Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).	N-glycosylated.;O-glycosylated. O-mannosylated by POMT1 and POMT2 and elongated by POMGNT1.	NA	NA	PE1	1
+NX_Q9UBT2	SUMO-activating enzyme subunit 2	640	71224	5.15	0	Cytoplasm;Nucleoplasm;Nucleus	NA	The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.	Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking.	Belongs to the ubiquitin-activating E1 family.	Protein modification; protein sumoylation.;Ubiquitin mediated proteolysis;SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9)	PE1	19
+NX_Q9UBT3	Dickkopf-related protein 4	224	24876	8.81	0	Secreted	NA	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).	Appears to be not glycosylated.;Can be proteolytically processed by a furin-like protease.	Belongs to the dickkopf family.	Wnt signaling pathway;TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	PE1	8
+NX_Q9UBT6	DNA polymerase kappa	870	98809	8.42	0	Nucleoplasm;Nucleus	NA	DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.	NA	Belongs to the DNA polymerase type-Y family.	Fanconi anemia pathway;Termination of translesion DNA synthesis;Translesion synthesis by POLK;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER	PE1	5
+NX_Q9UBT7	Alpha-catulin	734	81896	6.22	0	Cytoskeleton;Cell membrane	NA	May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).	NA	Belongs to the vinculin/alpha-catenin family.	NA	PE1	9
+NX_Q9UBU2	Dickkopf-related protein 2	259	28447	9.34	0	Golgi apparatus;Secreted	NA	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).	May be proteolytically processed by a furin-like protease.	Belongs to the dickkopf family.	Wnt signaling pathway;TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	PE1	4
+NX_Q9UBU3	Appetite-regulating hormone	117	12911	5.35	0	Secreted	NA	Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).;Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.	Amidation of Leu-98 is essential for obestatin activity.;O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid (PubMed:10604470).	Belongs to the motilin family.	Peptide ligand-binding receptors;G alpha (q) signalling events;Synthesis, secretion, and deacylation of Ghrelin	PE1	3
+NX_Q9UBU6	Protein FAM8A1	413	44123	6.76	3	Membrane;Golgi apparatus	NA	NA	NA	NA	NA	PE1	6
+NX_Q9UBU7	Protein DBF4 homolog A	674	76858	8.03	0	Nucleoplasm;Nucleus	NA	Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.	NA	NA	Activation of ATR in response to replication stress;Activation of the pre-replicative complex	PE1	7
+NX_Q9UBU8	Mortality factor 4-like protein 1	362	41474	9.29	0	Nucleus speckle;Nucleus	NA	Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.	NA	NA	HATs acetylate histones	PE1	15
+NX_Q9UBU9	Nuclear RNA export factor 1	619	70182	8.74	0	Cytoplasm;Nucleus speckle;Nuclear pore complex;Nucleoplasm;Nucleus envelope;Nucleus	NA	Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).	NA	Belongs to the NXF family.	Ribosome biogenesis in eukaryotes;RNA transport;mRNA surveillance pathway;Influenza A;Herpes simplex infection;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript	PE1	11
+NX_Q9UBV2	Protein sel-1 homolog 1	794	88755	5.23	1	Endoplasmic reticulum membrane	NA	Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.	N-glycosylated.	Belongs to the sel-1 family.	Protein processing in endoplasmic reticulum;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Pre-NOTCH Processing in Golgi;ER Quality Control Compartment (ERQC);ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis	PE1	14
+NX_Q9UBV4	Protein Wnt-16	365	40690	8.97	0	Extracellular matrix	NA	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors)	PE1	7
+NX_Q9UBV7	Beta-1,4-galactosyltransferase 7	327	37406	9.18	1	Golgi stack membrane	Ehlers-Danlos syndrome, spondylodysplastic type, 1	Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.	NA	Belongs to the glycosyltransferase 7 family.	Protein modification; protein glycosylation.;Glycosaminoglycan biosynthesis - chondroitin sulfate;Glycosaminoglycan biosynthesis - heparan sulfate;Metabolic pathways;A tetrasaccharide linker sequence is required for GAG synthesis;Defective B4GALT7 causes EDS, progeroid type	PE1	5
+NX_Q9UBV8	Peflin	284	30381	6.1	0	Cytoplasm;Membrane;Endoplasmic reticulum;COPII-coated vesicle membrane;Nucleoplasm;Cytoplasmic vesicle;Cytosol	NA	Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium (PubMed:27716508). Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (PubMed:11278427). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity).	Ubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex.	NA	NA	PE1	1
+NX_Q9UBW5	Bridging integrator 2	565	61874	5.11	0	Cytoplasm;Cell cortex;Cell membrane;Podosome membrane;Phagocytic cup	NA	Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.	NA	NA	Neutrophil degranulation	PE1	12
+NX_Q9UBW7	Zinc finger MYM-type protein 2	1377	154911	5.95	0	Endoplasmic reticulum;Nucleoplasm;Nucleus	NA	May function as a transcription factor.	NA	NA	Signaling by FGFR1 in disease;Signaling by cytosolic FGFR1 fusion mutants	PE1	13
+NX_Q9UBW8	COP9 signalosome complex subunit 7a	275	30277	8.33	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.	Phosphorylated by CK2 and PKD kinases.	Belongs to the CSN7/EIF3M family. CSN7 subfamily.	Formation of TC-NER Pre-Incision Complex;DNA Damage Recognition in GG-NER;Cargo recognition for clathrin-mediated endocytosis;Neddylation	PE1	12
+NX_Q9UBX0	Homeobox expressed in ES cells 1	185	21409	9.01	0	Nucleoplasm;Nucleus	Septooptic dysplasia;Pituitary hormone deficiency, combined, 5;Growth hormone deficiency with pituitary anomalies	Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation.	NA	Belongs to the ANF homeobox family.	NA	PE1	3
+NX_Q9UBX1	Cathepsin F	484	53366	8.52	0	Cytoplasmic vesicle;Cytosol;Cell membrane;Lysosome	Ceroid lipofuscinosis, neuronal, 13	Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.	NA	Belongs to the peptidase C1 family.	Lysosome;MHC class II antigen presentation	PE1	11
+NX_Q9UBX2	Double homeobox protein 4	424	44940	8.72	0	Nucleus	Facioscapulohumeral muscular dystrophy 1	Transcription factor that is selectively and transiently expressed in cleavage-stage embryos (PubMed:28459457). Binds to double-stranded DNA elements with the consensus sequence 5'-TAATCTAATCA-3' (PubMed:28459457, PubMed:28459454, PubMed:29572508, PubMed:30540931, PubMed:30315230). Binds to chromatin containing histone H3 acetylated at 'Lys-27' (H3K27ac) and promotes deacetylation of H3K27ac. In parallel, binds to chromatin that lacks histone H3 acetylation at 'Lys-27' (H3K27ac) and recruits EP300 and CREBBP to promote acetylation of histone H3 at 'Lys-27' at new sites (PubMed:26951377). Involved in transcriptional regulation of numerous genes, primarily as transcriptional activator, but mediates also repression of a set of target genes (PubMed:17984056, PubMed:27378237, PubMed:26951377, PubMed:28459457, PubMed:28459454, PubMed:29618456, PubMed:30540931, PubMed:29572508). Promotes expression of ZSCAN4 and KDM4E, two proteins with essential roles during early embryogenesis (PubMed:27378237, PubMed:26951377, PubMed:28459457, PubMed:29618456). Heterologous expression in cultured embryonic stem cells mediates also transcription of HERVL retrotransposons and transcripts derived from ACRO1 and HSATII satellite repeats (PubMed:28459457). May activate expression of PITX1 (PubMed:17984056). May regulate microRNA (miRNA) expression (PubMed:24145033). Inappropriate expression can inhibit myogenesis and promote apoptosis (PubMed:26951377, PubMed:28935672, PubMed:29618456).;Probably inactive as a transcriptional activator, due to the absence of the C-terminal region that is important for transcriptional activation. Can inhibit transcriptional activation mediated by isoform 1. Heterologous expression of isoform 2 has no deleterious effect on cell survival.	NA	Belongs to the paired homeobox family.	NA	PE1	4
+NX_Q9UBX3	Mitochondrial dicarboxylate carrier	287	31282	9.62	6	Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Proximal tubule bicarbonate reclamation;Gluconeogenesis;Sulfide oxidation to sulfate;Organic anion transporters	PE1	17
+NX_Q9UBX5	Fibulin-5	448	50180	4.58	0	Extracellular matrix;Secreted;Cell membrane	Cutis laxa, autosomal recessive, 1A;Neuropathy, hereditary, with or without age-related macular degeneration;Macular degeneration, age-related, 3;Cutis laxa, autosomal dominant, 2	Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).	N-glycosylated.	Belongs to the fibulin family.	Molecules associated with elastic fibres;Elastic fibre formation	PE1	14
+NX_Q9UBX7	Kallikrein-11	282	31059	9.23	0	Golgi apparatus;Secreted	NA	Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.	About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.	Belongs to the peptidase S1 family. Kallikrein subfamily.	NA	PE1	19
+NX_Q9UBX8	Beta-1,4-galactosyltransferase 6	382	44914	8.59	1	Golgi stack membrane	NA	Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:3099851, PubMed:1551920, PubMed:24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity).	NA	Belongs to the glycosyltransferase 7 family.	Protein modification; protein glycosylation.;Sphingolipid metabolism.;Sphingolipid metabolism;Metabolic pathways;O-linked glycosylation of mucins;Keratan sulfate biosynthesis;N-Glycan antennae elongation	PE1	18
+NX_Q9UBY0	Sodium/hydrogen exchanger 2	812	91520	9.2	10	Membrane;Cell junction	NA	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.	Phosphorylated (Possible).	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Sodium/Proton exchangers	PE1	2
+NX_Q9UBY5	Lysophosphatidic acid receptor 3	353	40128	9.53	7	Cell membrane	NA	Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;G alpha (q) signalling events;Lysosphingolipid and LPA receptors	PE1	1
+NX_Q9UBY8	Protein CLN8	286	32787	8.47	5	Endoplasmic reticulum;Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane	Ceroid lipofuscinosis, neuronal, 8;Ceroid lipofuscinosis, neuronal, 8, Northern epilepsy variant	Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.	Does not seem to be N-glycosylated.	NA	NA	PE1	8
+NX_Q9UBY9	Heat shock protein beta-7	170	18611	6.04	0	Cajal body;Nucleoplasm;Cytoplasm;Nucleus	NA	NA	NA	Belongs to the small heat shock protein (HSP20) family.	NA	PE1	1
+NX_Q9UBZ4	DNA-(apurinic or apyrimidinic site) lyase 2	518	57401	8.65	0	Cytoplasm;Mitochondrion;Nucleolus;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.	NA	Belongs to the DNA repair enzymes AP/ExoA family.	Base excision repair	PE1	X
+NX_Q9UBZ9	DNA repair protein REV1	1251	138248	8.76	0	Cytosol;Nucleus	NA	Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.	NA	Belongs to the DNA polymerase type-Y family.	Fanconi anemia pathway;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Translesion synthesis by REV1;Translesion synthesis by POLK	PE1	2
+NX_Q9UC06	Zinc finger protein 70	446	50802	8.68	0	Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	22
+NX_Q9UC07	Zinc finger protein 69	566	65761	9.13	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q9UD57	NK1 transcription factor-related protein 2	310	32381	9.7	0	Nucleus	NA	May function in cell specification, particularly in the CNS.	NA	Belongs to the NK-1 homeobox family.	NA	PE1	10
+NX_Q9UD71	Protein phosphatase 1 regulatory subunit 1B	204	22963	4.48	0	Cytoplasm	NA	Inhibitor of protein-phosphatase 1.	Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.;Phosphorylation of Thr-34 is required for activity.	Belongs to the protein phosphatase inhibitor 1 family.	Dopaminergic synapse;DARPP-32 events	PE1	17
+NX_Q9UDR5	Alpha-aminoadipic semialdehyde synthase, mitochondrial	926	102132	6.18	0	Cytoplasmic vesicle;Mitochondrion	2,4-dienoyl-CoA reductase deficiency;Hyperlysinemia, 1	Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.	NA	In the N-terminal section; belongs to the AlaDH/PNT family.;In the C-terminal section; belongs to the saccharopine dehydrogenase family.	Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.;Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.;Lysine biosynthesis;Lysine degradation;Metabolic pathways;Lysine catabolism	PE1	7
+NX_Q9UDT6	CAP-Gly domain-containing linker protein 2	1046	115837	6.29	0	Cytoplasm;Cytoskeleton	NA	Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).	NA	NA	NA	PE1	7
+NX_Q9UDV6	Zinc finger protein 212	495	55447	6.97	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q9UDV7	Zinc finger protein 282	671	74295	5.62	0	Nucleoplasm;Cytosol;Nucleus	NA	Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q9UDW1	Cytochrome b-c1 complex subunit 9	63	7308	9.45	0	Mitochondrion inner membrane	NA	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity).	NA	Belongs to the UQCR10/QCR9 family.	Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport	PE1	22
+NX_Q9UDW3	Zinc finger matrin-type protein 5	170	19971	8.85	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	mRNA Splicing - Minor Pathway	PE1	22
+NX_Q9UDX3	SEC14-like protein 4	406	46644	6.16	0	Centrosome	NA	Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.	NA	NA	NA	PE1	22
+NX_Q9UDX4	SEC14-like protein 3	400	46048	5.79	0	NA	NA	Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.	NA	NA	NA	PE1	22
+NX_Q9UDX5	Mitochondrial fission process protein 1	166	18010	9.33	3	Mitochondrion inner membrane;Mitochondrion	NA	Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.	NA	Belongs to the MTFP1 family.	NA	PE1	22
+NX_Q9UDY2	Tight junction protein ZO-2	1190	133958	6.96	0	Cell membrane;Cell junction;Adherens junction;Nucleoplasm;Tight junction;Nucleus	Familial hypercholanemia;Cholestasis, progressive familial intrahepatic, 4	Plays a role in tight junctions and adherens junctions.	NA	Belongs to the MAGUK family.	Tight junction;Vibrio cholerae infection;Signaling by Hippo;Apoptotic cleavage of cell adhesion proteins	PE1	9
+NX_Q9UDY4	DnaJ homolog subfamily B member 4	337	37807	8.65	0	Nucleoplasm;Cytoplasm;Cytosol;Cell membrane	NA	Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).	NA	NA	NA	PE1	1
+NX_Q9UDY6	Tripartite motif-containing protein 10	481	55037	5.69	0	Cytoplasm	NA	Seems to play an important role in erythropoiesis.	NA	Belongs to the TRIM/RBCC family.	Interferon gamma signaling	PE1	6
+NX_Q9UDY8	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	824	92272	5.47	0	Nucleus;Perinuclear region;Nucleolus;Cytosol	Immunodeficiency 12	Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity).	NA	Belongs to the peptidase C14B family.	T cell receptor signaling pathway;B cell receptor signaling pathway;Tuberculosis;Activation of NF-kappaB in B cells;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Downstream TCR signaling;CLEC7A/inflammasome pathway	PE1	18
+NX_Q9UEE5	Serine/threonine-protein kinase 17A	414	46558	5.08	0	Nucleus speckle;Nucleus;Cell membrane	NA	Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.	Autophosphorylated.;Autophosphorylated	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.	NA	PE1	7
+NX_Q9UEE9	Craniofacial development protein 1	299	33593	4.77	0	Cytoplasmic vesicle;Nucleoplasm;Kinetochore	NA	May play a role during embryogenesis.	Phosphorylated by CK2 (casein kinase II) in vitro.	NA	NA	PE1	16
+NX_Q9UEF7	Klotho	1012	116181	8.06	1	Apical cell membrane;Secreted;Cell membrane	Tumoral calcinosis, hyperphosphatemic, familial, 3	The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.;May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).	N-glycosylated.	Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.	Pentose and glucuronate interconversions;Starch and sucrose metabolism;Metabolic pathways;Endocrine and other factor-regulated calcium reabsorption;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;FGFR1c and Klotho ligand binding and activation;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade: FGFR1;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;Negative regulation of FGFR1 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Downstream signaling of activated FGFR1	PE1	13
+NX_Q9UEG4	Zinc finger protein 629	869	96620	8.24	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	16
+NX_Q9UER7	Death domain-associated protein 6	740	81373	4.8	0	Cytoplasm;Nucleolus;Nucleoplasm;Centromere;PML body;Nucleus	NA	Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915).	Sumoylated with SUMO1 on multiple lysine residues.;Phosphorylated by HIPK1 upon glucose deprivation.;Polyubiquitinated; which is promoted by CUL3 and SPOP and results in proteasomal degradation. Ubiquitinated by MDM2; inducing its degradation. Deubiquitinated by USP7; leading to stabilize it.;DAXX is phosphorylated by HIPK3	Belongs to the DAXX family.	MAPK signaling pathway;Amyotrophic lateral sclerosis (ALS);Herpes simplex infection;Regulation of TP53 Degradation;SUMOylation of transcription cofactors	PE1	6
+NX_Q9UET6	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase	329	36079	5.42	0	Cytoplasm;Cytosol	Mental retardation, X-linked 44	Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.	tRNA modification in the nucleus and cytosol	PE1	X
+NX_Q9UEU0	Vesicle transport through interaction with t-SNAREs homolog 1B	232	26688	9.02	1	Golgi apparatus;Lysosome membrane;Recycling endosome membrane;Early endosome membrane;Cytoplasmic vesicle;Cytoplasmic granule;Late endosome membrane	NA	V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.	NA	Belongs to the VTI1 family.	SNARE interactions in vesicular transport;Platelet degranulation	PE1	14
+NX_Q9UEU5	G antigen 2D	116	12764	4.23	0	NA	NA	NA	NA	Belongs to the GAGE family.	NA	PE1	X
+NX_Q9UEW3	Macrophage receptor MARCO	520	52658	8.95	1	Golgi apparatus;Cytoplasmic vesicle;Cell membrane	NA	Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263).	N-glycosylated.	NA	Phagosome;Scavenging by Class A Receptors	PE1	2
+NX_Q9UEW8	STE20/SPS1-related proline-alanine-rich protein kinase	545	59474	5.92	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.	Phosphorylated at Ser-309 by PRKCQ (PubMed:14988727). Autophosphorylation at Thr-231 positively regulates its activity (By similarity).	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	NA	PE1	2
+NX_Q9UEY8	Gamma-adducin	706	79155	5.92	0	Cell membrane;Cytoskeleton	Cerebral palsy, spastic quadriplegic 3	Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin.	Sumoylated.	Belongs to the aldolase class II family. Adducin subfamily.	Miscellaneous transport and binding events	PE1	10
+NX_Q9UF02	Voltage-dependent calcium channel gamma-5 subunit	275	30903	6.94	4	Membrane;Postsynaptic density	NA	Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).	NA	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE2	17
+NX_Q9UF11	Pleckstrin homology domain-containing family B member 1	243	27186	7	0	Membrane;Cytoplasm	NA	NA	NA	NA	NA	PE1	11
+NX_Q9UF12	Hydroxyproline dehydrogenase	536	58871	8.94	0	Nucleoplasm;Cytosol	NA	Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.	NA	Belongs to the proline oxidase family.	Arginine and proline metabolism;Metabolic pathways;Glyoxylate metabolism and glycine degradation;Proline catabolism	PE1	19
+NX_Q9UF33	Ephrin type-A receptor 6	1036	116379	6.55	1	Membrane;Nucleoplasm	NA	Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).	NA	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.	Axon guidance;EPH-Ephrin signaling;EPH-ephrin mediated repulsion of cells;EPHA-mediated growth cone collapse	PE1	3
+NX_Q9UF47	DnaJ homolog subfamily C member 5B	199	22496	5.16	0	Membrane	NA	NA	Palmitoylated. Palmitoylation is not required for membrane association.	NA	Protein processing in endoplasmic reticulum	PE1	8
+NX_Q9UF56	F-box/LRR-repeat protein 17	701	75695	8.49	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity).	NA	Belongs to the FBXL17 family.	NA	PE1	5
+NX_Q9UF83	Uncharacterized protein DKFZp434B061	564	59412	13.06	0	NA	NA	NA	NA	NA	NA	PE1	13
+NX_Q9UFB7	Zinc finger and BTB domain-containing protein 47	747	82760	5.52	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q9UFC0	Leucine-rich repeat and WD repeat-containing protein 1	647	70861	6.88	0	Nucleolus;Nucleoplasm;Centromere;Centrosome;Telomere;Cytoplasmic vesicle;Nucleus;Kinetochore	NA	Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.	Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination leading to proteasomal degradation. Ubiquitination occurs within the WD repeats at the end of the G1 phase. Ubiquitination may be catalyzed by the CUL4-DDB1 E3 ubiquitin-protein ligase complex and other E3 ligases.	Belongs to the LRWD1 family.	NA	PE1	7
+NX_Q9UFD9	RIMS-binding protein 3A	1639	180717	6.46	0	Cytoskeleton	NA	Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development.	NA	Belongs to the RIMBP family.	NA	PE1	22
+NX_Q9UFE4	Coiled-coil domain-containing protein 39	941	109901	6.1	0	Mitochondrion;Cilium axoneme	Ciliary dyskinesia, primary, 14	Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131972). Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly (PubMed:21131972).	NA	Belongs to the CCDC39 family.	NA	PE1	3
+NX_Q9UFF9	CCR4-NOT transcription complex subunit 8	292	33540	4.69	0	Cytoplasm;Nucleus	NA	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.	NA	Belongs to the CAF1 family.	RNA degradation;Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	5
+NX_Q9UFG5	UPF0449 protein C19orf25	118	12878	5.03	0	Cytoskeleton	NA	NA	NA	Belongs to the UPF0449 family.	NA	PE1	19
+NX_Q9UFH2	Dynein heavy chain 17, axonemal	4462	509313	5.52	0	Nucleoplasm;Cytosol;Cilium axoneme;Cell membrane	NA	Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).	NA	Belongs to the dynein heavy chain family.	NA	PE1	17
+NX_Q9UFN0	Protein NipSnap homolog 3A	247	28467	9.21	0	Cytosol	NA	NA	NA	Belongs to the NipSnap family.	NA	PE1	9
+NX_Q9UFP1	Golgi-associated kinase 1A	575	63637	7.1	0	Golgi apparatus;Secreted;Endoplasmic reticulum;Caveola;Cytoplasmic vesicle	NA	NA	O-glycosylated with core 1 or possibly core 8 glycans.;Proteolytically cleaved. Cleaved at Arg-120 and Arg-437 leading to a processed mature product of 35 kDa. The cleavage takes place in the Golgi apparatus.	Belongs to the GASK family.	NA	PE1	3
+NX_Q9UFV1	Putative TBC1 domain family member 29	150	16280	9.33	0	NA	NA	NA	NA	NA	NA	PE5	17
+NX_Q9UFV3	Putative uncharacterized protein DKFZp434L187	132	14889	10.08	0	NA	NA	NA	NA	NA	NA	PE5	15
+NX_Q9UFW8	CGG triplet repeat-binding protein 1	167	18820	9.14	0	Nucleoplasm;Nucleus	NA	Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter.	NA	NA	NA	PE1	3
+NX_Q9UG01	Intraflagellar transport protein 172 homolog	1749	197576	5.78	0	Cytoplasmic vesicle;Cilium	Short-rib thoracic dysplasia 10 with or without polydactyly;Retinitis pigmentosa 71	Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity).	NA	Belongs to the IFT172 family.	Intraflagellar transport;Hedgehog 'off' state	PE1	2
+NX_Q9UG22	GTPase IMAP family member 2	337	38017	8.6	0	Lipid droplet	NA	The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself.	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.	NA	PE1	7
+NX_Q9UG56	Phosphatidylserine decarboxylase proenzyme, mitochondrial	409	46672	9.51	1	Golgi apparatus;Cytosol;Mitochondrion inner membrane	NA	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.	Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.	Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.	Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PE	PE1	22
+NX_Q9UG63	ATP-binding cassette sub-family F member 2	623	71290	6.95	0	Cytosol	NA	NA	NA	Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.	NA	PE1	7
+NX_Q9UGB4	Putative uncharacterized protein C20orf187	50	5874	4.33	0	NA	NA	NA	NA	NA	NA	PE4	20
+NX_Q9UGB7	Inositol oxygenase	285	33010	5.5	0	Cytoplasm	NA	NA	NA	Belongs to the myo-inositol oxygenase family.	Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.;Ascorbate and aldarate metabolism;Inositol phosphate metabolism;Synthesis of IP2, IP, and Ins in the cytosol	PE1	22
+NX_Q9UGC6	Regulator of G-protein signaling 17	210	24359	5.56	0	Cytoplasm;Synaptosome;Membrane;Cytoplasmic vesicle;Nucleus	NA	Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).	N- and O-glycosylated in synapsomal membranes.;Serine phosphorylated in synapsomal membranes.;Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.	NA	G alpha (i) signalling events;G alpha (q) signalling events;G alpha (z) signalling events	PE1	6
+NX_Q9UGC7	Peptide chain release factor 1-like, mitochondrial	380	43600	8.36	0	Mitochondrion	NA	Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.	Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.	Belongs to the prokaryotic/mitochondrial release factor family.	Mitochondrial translation termination	PE1	6
+NX_Q9UGF5	Olfactory receptor 14J1	321	35892	8.9	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_Q9UGF6	Olfactory receptor 5V1	321	36057	8.79	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_Q9UGF7	Olfactory receptor 12D3	316	35791	8.86	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_Q9UGH3	Solute carrier family 23 member 2	650	70337	7.83	12	Golgi apparatus;Cytoplasmic vesicle;Cell membrane	NA	Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.	Phosphorylated.	Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.	Vitamin C (ascorbate) metabolism	PE1	20
+NX_Q9UGI0	Ubiquitin thioesterase ZRANB1	708	80967	5.48	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.	NA	Belongs to the peptidase C64 family.	Ovarian tumor domain proteases	PE1	10
+NX_Q9UGI6	Small conductance calcium-activated potassium channel protein 3	731	81385	9.12	6	Membrane;Nucleoplasm	NA	Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.	NA	Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.	Ca2+ activated K+ channels	PE1	1
+NX_Q9UGI8	Testin	421	47996	7.96	0	Cytoplasm;Cell membrane;Cell junction;Focal adhesion;Cytosol	NA	Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.	NA	Belongs to the prickle / espinas / testin family.	NA	PE1	7
+NX_Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	489	54258	5.59	0	NA	NA	AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.	Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.	Belongs to the 5'-AMP-activated protein kinase gamma subunit family.	Insulin signaling pathway;Adipocytokine signaling pathway;Hypertrophic cardiomyopathy (HCM);Macroautophagy;Translocation of SLC2A4 (GLUT4) to the plasma membrane;TP53 Regulates Metabolic Genes;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Energy dependent regulation of mTOR by LKB1-AMPK;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs;Lipophagy	PE1	2
+NX_Q9UGJ0	5'-AMP-activated protein kinase subunit gamma-2	569	63066	9.37	0	Nucleoplasm	Wolff-Parkinson-White syndrome;Glycogen storage disease of heart lethal congenital;Cardiomyopathy, familial hypertrophic 6	AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.	Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.	Belongs to the 5'-AMP-activated protein kinase gamma subunit family.	Insulin signaling pathway;Adipocytokine signaling pathway;Hypertrophic cardiomyopathy (HCM);Macroautophagy;Translocation of SLC2A4 (GLUT4) to the plasma membrane;TP53 Regulates Metabolic Genes;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Energy dependent regulation of mTOR by LKB1-AMPK;AMPK inhibits chREBP transcriptional activation activity;Import of palmitoyl-CoA into the mitochondrial matrix;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs;Lipophagy	PE1	7
+NX_Q9UGJ1	Gamma-tubulin complex component 4	667	76089	6.17	0	Centrosome	Microcephaly and chorioretinopathy, autosomal recessive, 3	Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.	NA	Belongs to the TUBGCP family.	Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes	PE1	15
+NX_Q9UGK3	Signal-transducing adaptor protein 2	403	44894	8.34	0	Cytoplasm	NA	Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.	Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC.	NA	PTK6 Activates STAT3	PE1	19
+NX_Q9UGK8	Secretion-regulating guanine nucleotide exchange factor	458	48981	6.01	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.	NA	NA	NA	PE1	11
+NX_Q9UGL1	Lysine-specific demethylase 5B	1544	175658	6.29	0	Nucleoplasm;Cytosol;Nucleus	Mental retardation, autosomal recessive 65	Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).	NA	Belongs to the JARID1 histone demethylase family.	HDMs demethylate histones;TFAP2 (AP-2) family regulates transcription of cell cycle factors	PE1	1
+NX_Q9UGL9	Cysteine-rich C-terminal protein 1	99	9736	9.13	0	NA	NA	NA	NA	NA	NA	PE1	1
+NX_Q9UGM1	Neuronal acetylcholine receptor subunit alpha-9	479	54807	6.04	4	Cell membrane;Postsynaptic cell membrane	NA	Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).	N-glycosylated.	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-9/CHRNA9 sub-subfamily.	Neuroactive ligand-receptor interaction;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	PE1	4
+NX_Q9UGM3	Deleted in malignant brain tumors 1 protein	2413	260735	5.18	0	Centriolar satellite;Secreted	Glioma	May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.	Highly N- and O-glycosylated. The O-glycans are heavily sulfated (By similarity).	Belongs to the DMBT1 family.	Surfactant metabolism	PE1	10
+NX_Q9UGM5	Fetuin-B	382	42055	6.46	0	Secreted	NA	Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).	NA	Belongs to the fetuin family.	NA	PE1	3
+NX_Q9UGM6	Tryptophan--tRNA ligase, mitochondrial	360	40147	9.31	0	Mitochondrion matrix;Mitochondrion;Cell membrane	Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures	Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	1
+NX_Q9UGN4	CMRF35-like molecule 8	299	33201	5.35	1	Cell membrane	NA	Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923).	N-glycosylated.;Phosphorylated on tyrosine.	Belongs to the CD300 family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Neutrophil degranulation	PE1	17
+NX_Q9UGN5	Poly [ADP-ribose] polymerase 2	583	66206	9.02	0	Nucleoplasm;Nucleus;Nucleolus	NA	Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:28190768, PubMed:25043379). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034).	Acetylation reduces DNA binding and enzymatic activity.;Poly-ADP-ribosylated by PARP1.	NA	Base excision repair;POLB-Dependent Long Patch Base Excision Repair;HDR through MMEJ (alt-NHEJ);DNA Damage Recognition in GG-NER;Dual Incision in GG-NER;Formation of Incision Complex in GG-NER	PE1	14
+NX_Q9UGP4	LIM domain-containing protein 1	676	72190	6.2	0	Cytoplasm;Adherens junction;Focal adhesion;Nucleoplasm;P-body;Nucleus	NA	Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation.	Phosphorylated during mitosis.	Belongs to the zyxin/ajuba family.	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	PE1	3
+NX_Q9UGP5	DNA polymerase lambda	575	63482	7.96	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195).	NA	Belongs to the DNA polymerase type-X family.	Base excision repair;Non-homologous end-joining;Nonhomologous End-Joining (NHEJ)	PE1	10
+NX_Q9UGP8	Translocation protein SEC63 homolog	760	87997	5.21	3	Endoplasmic reticulum;Endoplasmic reticulum membrane	Polycystic liver disease 2 with or without kidney cysts	Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).	NA	NA	Protein export;Protein processing in endoplasmic reticulum	PE1	6
+NX_Q9UGQ2	Calcium channel flower homolog	172	18470	5.37	3	Membrane;Nucleoplasm	NA	NA	NA	Belongs to the calcium channel flower family.	Presynaptic depolarization and calcium channel opening	PE1	9
+NX_Q9UGQ3	Solute carrier family 2, facilitated glucose transporter member 6	507	54539	8.9	12	Lysosome membrane	NA	Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose (PubMed:30431159).	NA	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.	Cellular hexose transport	PE1	9
+NX_Q9UGR2	Zinc finger CCCH domain-containing protein 7B	977	109858	6.94	0	Cytosol;Nucleus	NA	May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop.	NA	NA	NA	PE1	22
+NX_Q9UGT4	Sushi domain-containing protein 2	822	90208	5.84	1	Cell membrane	NA	May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994).	NA	NA	NA	PE1	22
+NX_Q9UGU0	Transcription factor 20	1960	211771	9.16	0	Nucleoplasm;Nucleus	NA	Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.	NA	NA	NA	PE1	22
+NX_Q9UGU5	HMG domain-containing protein 4	601	65712	9.35	0	Nucleus	NA	Negatively regulates Wnt/beta-catenin signaling during development.	NA	NA	NA	PE1	22
+NX_Q9UGV2	Protein NDRG3	375	41409	5.12	0	NA	NA	NA	NA	Belongs to the NDRG family.	NA	PE1	20
+NX_Q9UGY1	Nucleolar protein 12	213	24663	10.22	0	Nucleoplasm;Nucleolus;Cytoplasmic vesicle	NA	May bind to 28S rRNA.	NA	Belongs to the RRP17 family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	22
+NX_Q9UH03	Neuronal-specific septin-3	358	40704	6.74	0	Cytoplasm;Cell membrane;Nucleoplasm;Synapse;Cytoskeleton	NA	Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).	Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity).	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	NA	PE1	22
+NX_Q9UH17	DNA dC->dU-editing enzyme APOBEC-3B	382	45924	5.74	0	Nucleus	NA	DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	mRNA Editing: C to U Conversion;Formation of the Editosome	PE1	22
+NX_Q9UH36	SRR1-like protein	339	38573	5.31	0	Cytoplasm;Cytosol	NA	Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes.	NA	Belongs to the SRR1 family.	NA	PE1	22
+NX_Q9UH62	Armadillo repeat-containing X-linked protein 3	379	42501	8.6	1	Mitochondrion outer membrane;Cytoplasm;Golgi apparatus;Nucleoplasm;Cytosol;Nucleus	NA	Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.	NA	Belongs to the eutherian X-chromosome-specific Armcx family.	NA	PE1	X
+NX_Q9UH64	Putative protein CDKN2A-DT	79	8851	11.58	0	NA	NA	NA	NA	NA	NA	PE5	9
+NX_Q9UH65	Switch-associated protein 70	585	68998	5.66	0	Cytoplasm;Cell membrane;Lamellipodium;Nucleus;Cytoskeleton	NA	Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).	Tyrosine-phosphorylated.	NA	NA	PE1	11
+NX_Q9UH73	Transcription factor COE1	591	64464	9	0	Nucleus	NA	Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.	NA	Belongs to the COE family.	Transcriptional regulation of white adipocyte differentiation	PE1	5
+NX_Q9UH77	Kelch-like protein 3	587	64970	5.29	0	Cytosol;Cytoskeleton	Pseudohypoaldosteronism 2D	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity).	Phosphorylation at Ser-433 by PKA decreases the interaction with WNK4, Leading to inhibit WNK4 degradation by the BCR(KLHL3) complex (PubMed:26435498, PubMed:27727489). Phosphorylation at Ser-433 is increased by insulin (PubMed:26435498).	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	5
+NX_Q9UH90	F-box only protein 40	709	79782	6.69	0	Cytoplasm	NA	Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	3
+NX_Q9UH92	Max-like protein X	298	33300	8.18	0	Cytoplasm;Nucleus membrane;Nucleoplasm;Cytosol;Nucleus	NA	Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.	NA	NA	ChREBP activates metabolic gene expression	PE1	17
+NX_Q9UH99	SUN domain-containing protein 2	717	80311	6.27	1	Nucleus inner membrane;Nucleus envelope;Nucleus membrane;Endosome membrane	NA	As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.	The disulfid bond with SYNE2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction. The disulfid bond is proposed to be conserved in LINC complexes involved in force transmission.	NA	Meiotic synapsis	PE1	22
+NX_Q9UHA2	SS18-like protein 2	77	8835	5.62	0	Nucleoplasm;Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the SS18 family.	NA	PE1	3
+NX_Q9UHA3	Probable ribosome biogenesis protein RLP24	163	19621	9.99	0	Nucleoplasm;Nucleolus	NA	Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).	NA	Belongs to the eukaryotic ribosomal protein eL24 family.	Ribosome	PE1	15
+NX_Q9UHA4	Ragulator complex protein LAMTOR3	124	13623	6.72	0	Late endosome membrane	NA	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.	NA	Belongs to the LAMTOR3 family.	MAPK signaling pathway;Macroautophagy;MAP2K and MAPK activation;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;mTOR signalling;mTORC1-mediated signalling;Neutrophil degranulation;Regulation of PTEN gene transcription	PE1	4
+NX_Q9UHA7	Interleukin-36 alpha	158	17684	5.89	0	Secreted	NA	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.	N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).	Belongs to the IL-1 family.	Interleukin-36 pathway	PE1	2
+NX_Q9UHB4	NADPH-dependent diflavin oxidoreductase 1	597	66763	5.95	0	Nucleoplasm;Cytosol;Perinuclear region;Cytoskeleton	NA	Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1.	NA	In the N-terminal section; belongs to the flavodoxin family.;In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.;Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.	Cytosolic iron-sulfur cluster assembly	PE1	9
+NX_Q9UHB6	LIM domain and actin-binding protein 1	759	85226	6.41	0	Cytoplasm;Cell membrane;Focal adhesion;Stress fiber;Cytosol;Cytoskeleton	NA	Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity).	Phosphorylation of the C-terminal region by MAPK1/MAPK3 reduces its association with F-actin and contributes to actin filament reorganization and enhances cell motility.	NA	NA	PE1	12
+NX_Q9UHB7	AF4/FMR2 family member 4	1163	127459	9.33	0	Nucleoplasm;Nucleolus;Nucleus	CHOPS syndrome	Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.	NA	Belongs to the AF4 family.	Formation of RNA Pol II elongation complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation	PE1	5
+NX_Q9UHB9	Signal recognition particle subunit SRP68	627	70730	8.75	0	Cytoplasm;Cytosol;Nucleolus	NA	Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.	NA	Belongs to the SRP68 family.	Protein export;SRP-dependent cotranslational protein targeting to membrane	PE1	17
+NX_Q9UHC1	DNA mismatch repair protein Mlh3	1453	163711	6.33	0	Nucleoplasm;Nucleus	Hereditary non-polyposis colorectal cancer 7;Colorectal cancer	Probably involved in the repair of mismatches in DNA.	NA	Belongs to the DNA mismatch repair MutL/HexB family.	Mismatch repair;Meiotic recombination	PE1	14
+NX_Q9UHC3	Acid-sensing ion channel 3	531	58905	6.73	2	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	NA	Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.	Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ASIC3/ACCN3-ASIC2/ASIC2b channel, but does not activate a homomeric ASIC3 channel (By similarity).	Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily.	Stimuli-sensing channels	PE1	7
+NX_Q9UHC6	Contactin-associated protein-like 2	1331	148167	6.12	1	Membrane;Axon;Paranodal septate junction	Autism 15;Pitt-Hopkins-like syndrome 1	Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction.	NA	Belongs to the neurexin family.	Cell adhesion molecules (CAMs)	PE1	7
+NX_Q9UHC7	E3 ubiquitin-protein ligase makorin-1	482	53349	5.05	0	NA	NA	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.	Auto-ubiquitinated; which leads to proteasomal degradation.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;AKT phosphorylates targets in the cytosol;Regulation of PTEN stability and activity	PE1	7
+NX_Q9UHC9	NPC1-like intracellular cholesterol transporter 1	1359	148728	5.95	13	Cytoplasmic vesicle membrane;Apical cell membrane;Cell membrane	NA	Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.	Highly glycosylated.	Belongs to the patched family.	Fat digestion and absorption;Intestinal lipid absorption	PE1	7
+NX_Q9UHD0	Interleukin-19	177	20452	7.62	0	Secreted	NA	May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).	NA	Belongs to the IL-10 family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling	PE1	1
+NX_Q9UHD1	Cysteine and histidine-rich domain-containing protein 1	332	37490	8.1	0	Cytoplasm;Cytosol	NA	Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.	NA	NA	NA	PE1	11
+NX_Q9UHD2	Serine/threonine-protein kinase TBK1	729	83642	6.32	0	Cytoplasmic vesicle;Nucleoplasm;Cytoplasm	Glaucoma 1, open angle, P;Encephalopathy, acute, infection-induced, herpes-specific, 8;Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:10581243, PubMed:11839743, PubMed:15485837, PubMed:21138416, PubMed:25636800, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:26611359). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, TMEM173/STING and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595).	'Lys-63'-linked polyubiquitination by MIB1 after RNA virus infection, or by NRDP1 after LPS stimulation at Lys-30 and Lys-401, participates in kinase activation. 'Lys-48'-linked polyubiquitination at Lys-670 by DTX4 leads to proteasomal degradation. 'Lys-48'-linked polyubiquitination by TRAIP also leads to proteasomal degradation. 'Lys-63'-linked polyubiquitination by RNF128 at Lys-30 and Lys-401 leads to the activation of antiviral responses.;Autophosphorylation at Ser-172 activates the kinase, and is an essential step for virus-triggered signaling. Phosphorylated by IKBKB/IKKB at Ser-172. Phosphorylation requires homodimerization and ubiquitination at Lys-30 and Lys-401. Dephosphorylated at Ser-172 by PPM1B and this negatively regulates its role in mediating antiviral response.	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Toll-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Hepatitis C;Measles;Influenza A;Herpes simplex infection;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN;IRF3 mediated activation of type 1 IFN;STAT6-mediated induction of chemokines;TRAF3-dependent IRF activation pathway;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;TICAM1-dependent activation of IRF3/IRF7;Interleukin-37 signaling	PE1	12
+NX_Q9UHD4	Cell death activator CIDE-B	219	24678	9.01	0	NA	NA	Activates apoptosis.	NA	NA	NA	PE1	14
+NX_Q9UHD8	Septin-9	586	65401	9.06	0	Cytoskeleton	Hereditary neuralgic amyotrophy	Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.	NA	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	NA	PE1	17
+NX_Q9UHD9	Ubiquilin-2	624	65696	5.15	0	Cytoplasm;Cell membrane;Membrane;Autophagosome;Cytosol;Nucleus	Amyotrophic lateral sclerosis 15, with or without frontotemporal dementia	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).	Degraded during macroautophagy.	NA	Protein processing in endoplasmic reticulum;Cargo recognition for clathrin-mediated endocytosis	PE1	X
+NX_Q9UHE5	N-acetyltransferase 8	227	25619	9.08	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane	NA	Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).	NA	Belongs to the camello family.	Sulfur metabolism; glutathione metabolism.;Amyloid fiber formation	PE1	2
+NX_Q9UHE8	Metalloreductase STEAP1	339	39851	9.28	6	Endosome membrane	NA	Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.	NA	Belongs to the STEAP family.	Mineral absorption	PE1	7
+NX_Q9UHF0	Tachykinin-3	121	13438	6.74	0	Cytoplasmic vesicle;Secreted	Hypogonadotropic hypogonadism 10 with or without anosmia	Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function.	NA	Belongs to the tachykinin family.	G alpha (q) signalling events;Tachykinin receptors bind tachykinins	PE1	12
+NX_Q9UHF1	Epidermal growth factor-like protein 7	273	29618	8.58	0	Extracellular space	NA	Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.	NA	NA	NA	PE1	9
+NX_Q9UHF3	Putative N-acetyltransferase 8B	227	25366	9.39	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane	NA	May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).	NA	Belongs to the camello family.	Amyloid fiber formation	PE5	2
+NX_Q9UHF4	Interleukin-20 receptor subunit alpha	553	62485	4.78	1	Membrane;Cytosol	NA	The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.	NA	Belongs to the type II cytokine receptor family.	Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Interleukin-20 family signaling	PE1	6
+NX_Q9UHF5	Interleukin-17B	180	20437	9.46	0	Secreted	NA	Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.	NA	Belongs to the IL-17 family.	Cytokine-cytokine receptor interaction	PE1	5
+NX_Q9UHF7	Zinc finger transcription factor Trps1	1281	141521	7.53	0	Nucleoplasm;Nucleus	Tricho-rhino-phalangeal syndrome 3;Tricho-rhino-phalangeal syndrome 1;Tricho-rhino-phalangeal syndrome 2	Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.	Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites.	NA	NA	PE1	8
+NX_Q9UHG0	Doublecortin domain-containing protein 2	476	52834	5.84	0	Centriolar satellite;Cilium;Cilium axoneme;Kinocilium;Cytosol;Spindle;Cytoskeleton	Nephronophthisis 19;Dyslexia 2;Sclerosing cholangitis, neonatal;Deafness, autosomal recessive, 66	Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779).	NA	NA	NA	PE1	6
+NX_Q9UHG2	ProSAAS	260	27372	6.22	0	trans-Golgi network;Cytoplasmic vesicle;Secreted	NA	May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity).	O-glycosylated with a core 1 or possibly core 8 glycan.;Proteolytically cleaved in the Golgi.	NA	NA	PE1	X
+NX_Q9UHG3	Prenylcysteine oxidase 1	505	56640	5.8	0	Lysosome	NA	Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine.	The protein is glycosylated at one or more potential N-glycosylation sites.	Belongs to the prenylcysteine oxidase family.	NA	PE1	2
+NX_Q9UHH9	Inositol hexakisphosphate kinase 2	426	49186	6.37	0	Nucleoplasm;Nucleolus;Cell junction;Nucleus	NA	Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).	NA	Belongs to the inositol phosphokinase (IPK) family.	Phospholipid metabolism; phosphatidylinositol metabolism.;Interferon alpha/beta signaling;Synthesis of IPs in the nucleus	PE1	3
+NX_Q9UHI5	Large neutral amino acids transporter small subunit 2	535	58382	5.69	12	Basolateral cell membrane;Cytoplasm	NA	Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.	Protein digestion and absorption;Amino acid transport across the plasma membrane;Basigin interactions	PE1	14
+NX_Q9UHI6	Probable ATP-dependent RNA helicase DDX20	824	92241	6.49	0	Cytoplasm;Gem;Nucleoplasm;Cytosol;Nucleus	NA	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).	NA	Belongs to the DEAD box helicase family. DDX20 subfamily.	RNA transport;snRNP Assembly	PE1	1
+NX_Q9UHI7	Solute carrier family 23 member 1	598	64831	6.16	12	Cell membrane	NA	Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.	Phosphorylated.	Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.	Vitamin C (ascorbate) metabolism	PE1	5
+NX_Q9UHI8	A disintegrin and metalloproteinase with thrombospondin motifs 1	967	105358	6.4	0	Extracellular matrix;Cell membrane	NA	Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.	The precursor is cleaved by a furin endopeptidase.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	Degradation of the extracellular matrix;O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	21
+NX_Q9UHJ3	Scm-like with four MBT domains protein 1	866	98141	5.86	0	Nucleoplasm;Nucleus	NA	Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.	NA	NA	NA	PE1	3
+NX_Q9UHJ6	Sedoheptulokinase	478	51491	6.35	0	Cytoplasm;Nucleoplasm;Nucleus speckle	Sedoheptulokinase deficiency	Acts as a modulator of macrophage activation through control of glucose metabolism.	NA	Belongs to the FGGY kinase family.	Pentose phosphate pathway	PE1	17
+NX_Q9UHJ9	Post-GPI attachment to proteins factor 2	254	29400	8.47	5	Endoplasmic reticulum membrane;Cytoskeleton;Golgi apparatus membrane	Hyperphosphatasia with mental retardation syndrome 3	Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity).	NA	Belongs to the PGAP2 family.	NA	PE1	11
+NX_Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	495	56300	9.21	0	Nucleoplasm;Nucleus;Nucleolus	NA	Binds RNA.	NA	NA	NA	PE1	13
+NX_Q9UHK6	Alpha-methylacyl-CoA racemase	382	42387	6.07	0	Cytoplasmic vesicle;Peroxisome;Mitochondrion;Cell membrane	Alpha-methylacyl-CoA racemase deficiency;Congenital bile acid synthesis defect 4	Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359).	NA	Belongs to the CoA-transferase III family.	Lipid metabolism; bile acid biosynthesis.;Lipid metabolism; fatty acid metabolism.;Primary bile acid biosynthesis;Metabolic pathways;Peroxisome;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import	PE1	5
+NX_Q9UHL0	ATP-dependent RNA helicase DDX25	483	54692	5.89	0	Cytoplasm;Nucleus	NA	ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity).	Phosphorylated on threonine residues. The phosphorylated form is found in the cytoplasm but not in the nucleus (By similarity).	Belongs to the DEAD box helicase family.	NA	PE1	11
+NX_Q9UHL3	Protein FAM153A	310	34712	4.68	0	NA	NA	NA	NA	Belongs to the FAM153 family.	NA	PE2	5
+NX_Q9UHL4	Dipeptidyl peptidase 2	492	54341	5.91	0	Golgi apparatus;Cytoplasmic vesicle;Secreted;Lysosome	NA	Plays an important role in the degradation of some oligopeptides.	N-glycosylated.	Belongs to the peptidase S28 family.	Neutrophil degranulation	PE1	9
+NX_Q9UHL9	General transcription factor II-I repeat domain-containing protein 1	959	106057	6.45	0	Nucleoplasm;Cytosol;Nucleus	NA	May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity).	NA	Belongs to the TFII-I family.	Basal transcription factors;Herpes simplex infection	PE1	7
+NX_Q9UHM6	Melanopsin	478	52635	9.35	7	Cell membrane	NA	Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).	NA	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	G alpha (q) signalling events;Opsins	PE1	10
+NX_Q9UHN1	DNA polymerase subunit gamma-2, mitochondrial	485	54911	8.64	0	Mitochondrion;Nucleus	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 4	Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.	NA	NA	Metabolic pathways;Transcriptional activation of mitochondrial biogenesis	PE1	17
+NX_Q9UHN6	Cell surface hyaluronidase	1383	154374	8.41	1	Cytoplasmic vesicle;Cell membrane	NA	Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172).	NA	Belongs to the CEMIP family.	NA	PE1	9
+NX_Q9UHP3	Ubiquitin carboxyl-terminal hydrolase 25	1055	122218	5.22	0	Cytoplasm;Cytosol;Nucleus	NA	Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.;The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.	Preferentially monoubiquitinated but can also be polyubiquitinated. Autodeubiquitinated. Ubiquitination activates the enzymatic activity either by preventing sumoylation or by allowing novel interactions.;Phosphorylation in the C-terminal by SYK regulates USP25 cellular levels.;Sumoylation impairs binding to and hydrolysis of ubiquitin chains. Sumoylated preferentially with SUMO2 or SUMO3. Desumoylated by SENP1. Regulated by ubiquitination on the same residue.;Acetylated.	Belongs to the peptidase C19 family.	Ub-specific processing proteases	PE1	21
+NX_Q9UHP6	Radial spoke head 14 homolog	348	38592	6.43	0	Nucleolus	NA	NA	NA	Belongs to the flagellar radial spoke RSP14 family.	NA	PE1	22
+NX_Q9UHP7	C-type lectin domain family 2 member D	191	21849	6.37	1	Golgi apparatus;Endoplasmic reticulum;Nucleoplasm;Cell membrane	NA	Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).	N-glycosylated.	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	12
+NX_Q9UHP9	Small muscular protein	88	9559	9.21	0	Cell membrane	Deafness, X-linked, 4	Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.	NA	Belongs to the SMPX family.	NA	PE1	X
+NX_Q9UHQ1	Nuclear prelamin A recognition factor	456	51156	6.63	0	Nucleoplasm;Nucleolus;Nucleus	NA	NA	NA	Belongs to the NARF family.	NA	PE1	17
+NX_Q9UHQ4	B-cell receptor-associated protein 29	241	28320	9.55	3	Cytosol;Endoplasmic reticulum membrane	NA	May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity).	NA	Belongs to the BCAP29/BCAP31 family.	NA	PE1	7
+NX_Q9UHQ7	Transcription elongation factor A protein-like 9	104	12749	5.35	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the TFS-II family. TFA subfamily.	NA	PE1	X
+NX_Q9UHQ9	NADH-cytochrome b5 reductase 1	305	34095	9.41	1	Membrane;Cytosol;Mitochondrion;Nucleolus	NA	NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	NA	Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Amino sugar and nucleotide sugar metabolism;Platelet degranulation;Erythrocytes take up carbon dioxide and release oxygen	PE1	1
+NX_Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	511	56883	8.82	0	Cytosol;Cytoskeleton;Cell membrane	NA	May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.	Phosphorylated on tyrosine in response to insulin.	NA	NA	PE1	7
+NX_Q9UHR5	SAP30-binding protein	308	33870	4.74	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.	NA	Belongs to the HCNGP family.	NoRC negatively regulates rRNA expression	PE1	17
+NX_Q9UHR6	Zinc finger HIT domain-containing protein 2	403	42884	5.69	0	NA	NA	May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (PubMed:28561026). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (PubMed:28561026). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026).	NA	NA	NA	PE1	11
+NX_Q9UHT4	Putative uncharacterized protein PRO1854	67	8314	10.1	0	NA	NA	NA	NA	NA	NA	PE5	7
+NX_Q9UHU1	Putative uncharacterized protein PRO1716	43	4899	8.16	0	NA	NA	NA	NA	NA	NA	PE5	11
+NX_Q9UHV2	SERTA domain-containing protein 1	236	24704	4.29	0	Golgi apparatus;Nucleoplasm	NA	Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.	Polyubiquitinated, which promotes proteasomal degradation.	NA	NA	PE1	19
+NX_Q9UHV5	Rap guanine nucleotide exchange factor-like 1	662	73265	5.94	0	Nucleoplasm;Cytoskeleton	NA	Probable guanine nucleotide exchange factor (GEF).	NA	NA	NA	PE1	17
+NX_Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	2174	239297	5.4	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	MED13 is phosphorylated by CDK8	Belongs to the Mediator complex subunit 13 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	17
+NX_Q9UHV8	Galactoside-binding soluble lectin 13	139	16119	5.43	0	Cytoplasm;Nucleus matrix	NA	Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis (PubMed:10527825, PubMed:19497882). Has hemagglutinating activity towards chicken erythrocytes (PubMed:29343868).	NA	NA	NA	PE1	19
+NX_Q9UHV9	Prefoldin subunit 2	154	16648	6.2	0	Cytoplasm;Cytosol;Mitochondrion;Nucleus	NA	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.	NA	Belongs to the prefoldin subunit beta family.	Prefoldin mediated transfer of substrate to CCT/TriC	PE1	1
+NX_Q9UHW5	GPN-loop GTPase 3	284	32761	4.38	0	Cytosol;Nucleus speckle	NA	Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.	NA	Belongs to the GPN-loop GTPase family.	NA	PE1	12
+NX_Q9UHW9	Solute carrier family 12 member 6	1150	127617	6.64	12	Basolateral cell membrane;Cytosol;Cytoplasmic vesicle	Agenesis of the corpus callosum, with peripheral neuropathy	Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.	N-glycosylated.	Belongs to the SLC12A transporter family.	Cation-coupled Chloride cotransporters;Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	PE1	15
+NX_Q9UHX1	Poly(U)-binding-splicing factor PUF60	559	59875	5.19	0	Cytoplasm;Nucleoplasm;Nucleus	Verheij syndrome	May contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.;Failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer.;DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells.	NA	Belongs to the RRM half pint family.	Spliceosome;mRNA Splicing - Major Pathway	PE1	8
+NX_Q9UHX3	Adhesion G protein-coupled receptor E2	823	90472	6.47	7	Ruffle membrane;Cytoplasmic vesicle;Cytosol;Cell membrane	Vibratory urticaria	Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242).	Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.	Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.	Class B/2 (Secretin family receptors)	PE1	19
+NX_Q9UHY1	Nuclear receptor-binding protein	535	59845	5.02	0	Lamellipodium;Cell cortex;Endomembrane system;Cytosol	NA	May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	Nuclear Receptor transcription pathway	PE1	2
+NX_Q9UHY7	Enolase-phosphatase E1	261	28933	4.66	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).	NA	Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.	Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.;Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.;Cysteine and methionine metabolism;Methionine salvage pathway	PE1	4
+NX_Q9UHY8	Fasciculation and elongation protein zeta-2	353	39666	4.52	0	Golgi apparatus;Cytosol;Nucleolus	NA	Involved in axonal outgrowth and fasciculation.	NA	Belongs to the zygin family.	NA	PE1	2
+NX_Q9UI08	Ena/VASP-like protein	416	44620	8.91	0	Stress fiber;Lamellipodium;Cytoplasmic vesicle;Cytosol;Cytoskeleton	NA	Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.	Phosphorylated by PKA; phosphorylation abolishes binding to SH3 domains of ABL and SRC.	Belongs to the Ena/VASP family.	Generation of second messenger molecules;RHO GTPases Activate Formins;Signaling by ROBO receptors	PE1	14
+NX_Q9UI09	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	145	17114	9.63	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 23	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I NDUFA12 subunit family.	Oxidative phosphorylation;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	12
+NX_Q9UI10	Translation initiation factor eIF-2B subunit delta	523	57557	9.45	0	Nucleus membrane;Cytoskeleton	Leukodystrophy with vanishing white matter	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.	NA	Belongs to the eIF-2B alpha/beta/delta subunits family.	RNA transport;Recycling of eIF2:GDP	PE1	2
+NX_Q9UI12	V-type proton ATPase subunit H	483	55883	6.07	0	Cytosol;Cytoskeleton	NA	Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.	NA	Belongs to the V-ATPase H subunit family.	Oxidative phosphorylation;Metabolic pathways;Lysosome;Phagosome;Synaptic vesicle cycle;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Tuberculosis;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport;Nef Mediated CD8 Down-regulation;Nef Mediated CD4 Down-regulation	PE1	8
+NX_Q9UI14	Prenylated Rab acceptor protein 1	185	20648	6.83	4	Golgi apparatus;Cytoplasm;Cell membrane;Nucleus membrane;Nucleolus;Synaptic vesicle	NA	General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.	NA	Belongs to the PRA1 family.	NA	PE1	19
+NX_Q9UI15	Transgelin-3	199	22473	6.84	0	NA	NA	NA	NA	Belongs to the calponin family.	NA	PE1	3
+NX_Q9UI17	Dimethylglycine dehydrogenase, mitochondrial	866	96811	7.31	0	Mitochondrion	DMGDH deficiency	Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro.	NA	Belongs to the GcvT family.	Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 2/2.;Glycine, serine and threonine metabolism;Metabolic pathways;Choline catabolism	PE1	5
+NX_Q9UI25	Putative uncharacterized protein PRO0461	63	6971	6.23	0	NA	NA	NA	NA	NA	NA	PE5	16
+NX_Q9UI26	Importin-11	975	112535	5.14	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).	NA	Belongs to the importin beta family.	NA	PE1	5
+NX_Q9UI30	Multifunctional methyltransferase subunit TRM112-like protein	125	14199	5.21	0	Nucleoplasm;Perinuclear region;Cytoskeleton	NA	Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604).	NA	Belongs to the TRM112 family.	Methylation;Eukaryotic Translation Termination;tRNA modification in the nucleus and cytosol;rRNA modification in the nucleus and cytosol	PE1	11
+NX_Q9UI32	Glutaminase liver isoform, mitochondrial	602	66323	6.9	0	Mitochondrion	NA	Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.	NA	Belongs to the glutaminase family.	Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;D-Glutamine and D-glutamate metabolism;Nitrogen metabolism;Metabolic pathways;Glutamatergic synapse;GABAergic synapse;Proximal tubule bicarbonate reclamation;TP53 Regulates Metabolic Genes;Glutamate Neurotransmitter Release Cycle;Glutamate and glutamine metabolism	PE1	12
+NX_Q9UI33	Sodium channel protein type 11 subunit alpha	1791	204922	8.32	24	Cell membrane	Episodic pain syndrome, familial, 3;Neuropathy, hereditary sensory and autonomic, 7	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.	Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	3
+NX_Q9UI36	Dachshund homolog 1	758	78562	8.75	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).	NA	Belongs to the DACH/dachshund family.	NA	PE1	13
+NX_Q9UI38	Probable threonine protease PRSS50	385	43088	8.58	0	Endoplasmic reticulum	NA	May be involved in proteolysis through its threonine endopeptidase activity.	NA	Belongs to the peptidase S1 family.	NA	PE1	3
+NX_Q9UI40	Sodium/potassium/calcium exchanger 2	661	73664	5.71	11	Membrane	NA	Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).	NA	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.	Sodium/Calcium exchangers	PE1	9
+NX_Q9UI42	Carboxypeptidase A4	421	47351	6.23	0	Nucleoplasm;Cytosol;Centrosome;Secreted	NA	Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563).	NA	Belongs to the peptidase M14 family.	NA	PE1	7
+NX_Q9UI43	rRNA methyltransferase 2, mitochondrial	246	27424	9.6	0	Mitochondrion	NA	S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.	rRNA modification in the mitochondrion	PE1	7
+NX_Q9UI46	Dynein intermediate chain 1, axonemal	699	79283	6.4	0	Cilium;Cilium axoneme	Kartagener syndrome;Ciliary dyskinesia, primary, 1	Part of the dynein complex of respiratory cilia.	NA	Belongs to the dynein intermediate chain family.	Huntington's disease	PE1	9
+NX_Q9UI47	Catenin alpha-3	895	99809	5.83	0	Cytoskeleton	Arrhythmogenic right ventricular dysplasia, familial, 13	May be involved in formation of stretch-resistant cell-cell adhesion complexes.	NA	Belongs to the vinculin/alpha-catenin family.	Adherens junction;Tight junction;Leukocyte transendothelial migration;Bacterial invasion of epithelial cells;Pathways in cancer;Endometrial cancer;Arrhythmogenic right ventricular cardiomyopathy (ARVC)	PE1	10
+NX_Q9UI54	Putative uncharacterized protein PRO0628	55	6387	10.3	0	NA	NA	NA	NA	NA	NA	PE5	20
+NX_Q9UI72	Putative uncharacterized protein PRO0255	69	8249	9.35	0	NA	NA	NA	NA	NA	NA	PE5	5
+NX_Q9UI95	Mitotic spindle assembly checkpoint protein MAD2B	211	24334	6.05	0	Cytoplasm;Nucleolus;Chromosome;Cytosol;Spindle;Nucleus	Fanconi anemia, complementation group V	Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:17719540, PubMed:17296730, PubMed:19443654, PubMed:29656893). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:20164194). Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194). Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 (PubMed:17296730). Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle (PubMed:11459825, PubMed:17719540). Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (PubMed:19443654).	NA	NA	Cell cycle;Oocyte meiosis;Progesterone-mediated oocyte maturation;Bacterial invasion of epithelial cells;Shigellosis;Translesion synthesis by POLI;Translesion synthesis by REV1;Translesion synthesis by POLK	PE1	1
+NX_Q9UIA0	Cytohesin-4	394	45672	6.08	0	Cell membrane	NA	Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.	NA	NA	Intra-Golgi traffic	PE1	22
+NX_Q9UIA9	Exportin-7	1087	123907	5.91	0	Cytoplasm;Nucleus;Nuclear pore complex	NA	Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.	NA	Belongs to the exportin family.	NA	PE1	8
+NX_Q9UIB8	SLAM family member 5	345	38782	6.61	1	Cytoplasmic vesicle;Cell membrane	NA	Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592).	N-glycosylated.;Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A is dependent of tyrosine phosphorylation of its cytoplasmic domain. Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation. Phosphorylated on tyrosine residues upon high affinity immunoglobulin epsilon receptor aggregation in mast cells.	NA	Cell surface interactions at the vascular wall	PE1	1
+NX_Q9UIC8	Leucine carboxyl methyltransferase 1	334	38379	5.73	0	Nucleoplasm;Cytosol	NA	Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.	NA	Belongs to the methyltransferase superfamily. LCMT family.	Histidine metabolism;Tyrosine metabolism;Cyclin A/B1/B2 associated events during G2/M transition	PE1	16
+NX_Q9UID3	Vacuolar protein sorting-associated protein 51 homolog	782	86042	6.06	0	trans-Golgi network;Golgi apparatus;Recycling endosome;Nucleolus;Cytoplasmic vesicle	NA	Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).	NA	Belongs to the VPS51 family.	Retrograde transport at the Trans-Golgi-Network	PE1	11
+NX_Q9UID6	Zinc finger protein 639	485	56054	5.3	0	Nucleoplasm;Nucleus	NA	Binds DNA and may function as a transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q9UIE0	Zinc finger protein 230	474	54542	8.75	0	Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9UIF3	Tektin-2	430	49672	5.39	0	Flagellum axoneme;Microtubule organizing center;Cilium axoneme;Cytoskeleton	NA	Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.	Tyrosine phosphorylated.	Belongs to the tektin family.	NA	PE1	1
+NX_Q9UIF7	Adenine DNA glycosylase	546	60069	8.99	0	Nucleoplasm;Mitochondrion;Nucleus	Familial adenomatous polyposis 2;Gastric cancer	Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.	NA	Belongs to the Nth/MutY family.	Base excision repair;Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Displacement of DNA glycosylase by APEX1;Defective MUTYH substrate binding;Defective MUTYH substrate processing	PE1	1
+NX_Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	2168	240459	6.13	0	Nucleoplasm;Cytosol;Nucleus	NA	May play a role in transcriptional regulation interacting with ISWI.	NA	Belongs to the WAL family.	NA	PE1	2
+NX_Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	1905	211198	6.22	0	Nucleus speckle;Nucleolus	NA	Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).	Acetylation at Lys-680 by KAT8/MOF promotes its dissociation from pRNA, affecting heterochromatin formation, nucleosome positioning and rDNA silencing. Deacetylation by SIRT1 in late S phase enhances pRNA-binding, allowing de novo DNA methylation and heterochromatin formation. Acetylation is high during S phase and declines to background levels in late S phase when the silent copies of rRNA genes are replicated (By similarity).;Ubiquitinated. Deubiquitinated by USP21 leading to its stabilization.	Belongs to the WAL family.	NoRC negatively regulates rRNA expression	PE1	12
+NX_Q9UIG0	Tyrosine-protein kinase BAZ1B	1483	170903	8.7	0	Nucleus	NA	Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.	NA	Belongs to the WAL family. BAZ1B subfamily.	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;B-WICH complex positively regulates rRNA expression	PE1	7
+NX_Q9UIG4	Psoriasis susceptibility 1 candidate gene 2 protein	136	15101	4.48	0	Secreted	NA	NA	NA	NA	NA	PE1	6
+NX_Q9UIG5	Psoriasis susceptibility 1 candidate gene 1 protein	152	16580	5.93	0	Nucleoplasm	NA	NA	NA	NA	NA	PE2	6
+NX_Q9UIG8	Solute carrier organic anion transporter family member 3A1	710	76553	6.34	12	Cell membrane	NA	Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).	NA	Belongs to the organo anion transporter (TC 2.A.60) family.	Transport of organic anions	PE1	15
+NX_Q9UIH9	Krueppel-like factor 15	416	43992	8.48	0	Nucleus	NA	Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	BMAL1:CLOCK,NPAS2 activates circadian gene expression	PE1	3
+NX_Q9UII2	ATPase inhibitor, mitochondrial	106	12249	9.34	0	Mitochondrion	NA	Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.	Exhibits variability in chain length, mitochondria have distinct pools of protein cleaved after the 24th, 25th, and 26th amino acid.	Belongs to the ATPase inhibitor family.	NA	PE1	1
+NX_Q9UII4	E3 ISG15--protein ligase HERC5	1024	116852	7.71	0	Perinuclear region	NA	Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.	ISGylated.	NA	Focal adhesion;Neurotrophin signaling pathway;Insulin signaling pathway;Renal cell carcinoma;Antigen processing: Ubiquitination &amp; Proteasome degradation;ISG15 antiviral mechanism;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Negative regulators of DDX58/IFIH1 signaling	PE1	4
+NX_Q9UII5	Zinc finger protein 107	783	90673	9.43	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	7
+NX_Q9UII6	Dual specificity protein phosphatase 13 isoform B	198	22149	9.27	0	NA	NA	Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	10
+NX_Q9UIJ5	Palmitoyltransferase ZDHHC2	367	42022	8.7	4	Membrane	NA	Palmitoyltransferase specific for GAP43 and DLG4/PSD95.	NA	Belongs to the DHHC palmitoyltransferase family.	Surfactant metabolism	PE1	8
+NX_Q9UIJ7	GTP:AMP phosphotransferase AK3, mitochondrial	227	25565	9.15	0	Mitochondrion matrix;Mitochondrion	NA	Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	NA	Belongs to the adenylate kinase family. AK3 subfamily.	Pyrimidine metabolism;Factors involved in megakaryocyte development and platelet production	PE1	9
+NX_Q9UIK4	Death-associated protein kinase 2	370	42898	6.45	0	Golgi apparatus;Cytoplasm;Autophagosome lumen;Cytoplasmic vesicle	NA	Is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.;Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).	Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.	Pathways in cancer;Bladder cancer;Caspase activation via Dependence Receptors in the absence of ligand	PE1	15
+NX_Q9UIK5	Tomoregulin-2	374	41428	5.01	1	Membrane;Secreted	NA	May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.	A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.;N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.	Belongs to the tomoregulin family.	NA	PE1	2
+NX_Q9UIL1	Short coiled-coil protein	159	18045	9	0	trans-Golgi network;Golgi apparatus;Nucleoplasm;Golgi apparatus membrane;Cytosol	NA	Positive regulator of amino acid starvation-induced autophagy.	NA	Belongs to the SCOC family.	Retrograde transport at the Trans-Golgi-Network	PE1	4
+NX_Q9UIL4	Kinesin-like protein KIF25	384	40686	8.61	0	Centrosome	NA	Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE2	6
+NX_Q9UIL8	PHD finger protein 11	331	37582	7.87	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Positive regulator of Th1-type cytokine gene expression.	NA	NA	NA	PE1	13
+NX_Q9UIM3	FK506-binding protein-like	349	38176	5.38	0	Nucleoplasm;Spindle	NA	May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.	NA	NA	The role of GTSE1 in G2/M progression after G2 checkpoint	PE1	6
+NX_Q9UIQ6	Leucyl-cystinyl aminopeptidase	1025	117349	5.5	1	Secreted;Cell membrane	NA	Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.	N-glycosylated.;The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.	Belongs to the peptidase M1 family.	Renin-angiotensin system;Antigen processing: Ubiquitination &amp; Proteasome degradation;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Endosomal/Vacuolar pathway	PE1	5
+NX_Q9UIR0	Butyrophilin-like protein 2	455	50436	4.96	1	Membrane	Sarcoidosis 2	Negative regulator of T-cell proliferation.	NA	Belongs to the immunoglobulin superfamily. BTN/MOG family.	Butyrophilin (BTN) family interactions	PE2	6
+NX_Q9UIS9	Methyl-CpG-binding domain protein 1	605	66607	9.32	0	Nucleus speckle;Nucleus matrix;Chromosome;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	Can also repress transcription from unmethylated promoters.;Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation.	Sumoylated with SUMO1 by PIAS1 and PIAS3. Sumoylation affects transcriptional silencing by preventing the interaction with SETDB1. In contrast, sumoylation may increase interaction with AFT7IP.	NA	SUMOylation of transcription cofactors	PE1	18
+NX_Q9UIU6	Homeobox protein SIX4	781	82933	5.45	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis.	NA	Belongs to the SIX/Sine oculis homeobox family.	NA	PE1	14
+NX_Q9UIV1	CCR4-NOT transcription complex subunit 7	285	32745	4.77	0	P-body;Nucleus	NA	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.	NA	Belongs to the CAF1 family.	RNA degradation;Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	8
+NX_Q9UIV8	Serpin B13	391	44276	5.48	0	Cytoplasm;Cytosol;Nucleus speckle	NA	May play a role in the proliferation or differentiation of keratinocytes.	NA	Belongs to the serpin family. Ov-serpin subfamily.	Amoebiasis;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	PE1	18
+NX_Q9UIW0	Ventral anterior homeobox 2	290	30874	9.56	0	Nucleus speckle;Nucleus	NA	Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina.	NA	Belongs to the EMX homeobox family.	NA	PE1	2
+NX_Q9UIW2	Plexin-A1	1896	211067	6.49	1	Nucleoplasm;Cytosol;Cell membrane	NA	Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).	NA	Belongs to the plexin family.	Axon guidance;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Sema3A PAK dependent Axon repulsion;CRMPs in Sema3A signaling;Other semaphorin interactions	PE1	3
+NX_Q9UIX4	Potassium voltage-gated channel subfamily G member 1	513	57913	5.94	6	Cytoplasmic vesicle;Cell membrane	NA	Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).	NA	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily.	Voltage gated Potassium channels	PE1	20
+NX_Q9UIY3	RWD domain-containing protein 2A	292	33893	6.01	0	Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	6
+NX_Q9UJ04	Testis-specific Y-encoded-like protein 4	414	45126	8.8	0	NA	NA	NA	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	6
+NX_Q9UJ14	Glutathione hydrolase 7	662	70467	4.96	1	Membrane;Cytoplasmic vesicle;Nucleoplasm	NA	Cleaves glutathione conjugates.	NA	Belongs to the gamma-glutamyltransferase family.	Sulfur metabolism; glutathione metabolism.;Taurine and hypotaurine metabolism;Cyanoamino acid metabolism;Glutathione metabolism;Arachidonic acid metabolism;Metabolic pathways;Aflatoxin activation and detoxification;Glutathione synthesis and recycling	PE1	20
+NX_Q9UJ37	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	374	41939	9.38	1	Golgi apparatus membrane	NA	Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.	NA	Belongs to the glycosyltransferase 29 family.	Protein modification; protein glycosylation.;Sialic acid metabolism;Termination of O-glycan biosynthesis	PE1	17
+NX_Q9UJ41	Rab5 GDP/GTP exchange factor	491	56891	6.66	0	Cytoplasm;Recycling endosome;Early endosome;Nucleolus;Cytosol	NA	Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).	Monoubiquitinated.	NA	RAB GEFs exchange GTP for GDP on RABs;TBC/RABGAPs	PE1	7
+NX_Q9UJ42	Probable G-protein coupled receptor 160	338	39787	8.84	7	Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE2	3
+NX_Q9UJ55	MAGE-like protein 2	1249	132822	9.55	0	Cytoplasm;Early endosome;Nucleus	Schaaf-Yang syndrome	Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (PubMed:23452853). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (By similarity).	NA	NA	NA	PE1	15
+NX_Q9UJ68	Mitochondrial peptide methionine sulfoxide reductase	235	26132	8.22	0	Cytoplasm;Mitochondrion;Cell membrane;Membrane;Nucleoplasm;Cytosol;Nucleus	NA	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.	NA	Belongs to the MsrA Met sulfoxide reductase family.	Protein repair	PE1	8
+NX_Q9UJ70	N-acetyl-D-glucosamine kinase	344	37376	5.82	0	Nucleoplasm;Cytosol	NA	Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.	NA	Belongs to the eukaryotic-type N-acetylglucosamine kinase family.	Amino-sugar metabolism; N-acetylneuraminate degradation.;Amino sugar and nucleotide sugar metabolism;Synthesis of UDP-N-acetyl-glucosamine	PE1	2
+NX_Q9UJ71	C-type lectin domain family 4 member K	328	36725	8.45	1	Membrane;Cytosol	Birbeck granule deficiency	Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.	NA	NA	Cross-presentation of soluble exogenous antigens (endosomes)	PE1	2
+NX_Q9UJ72	Annexin A10	324	37278	5.13	0	Nucleoplasm;Nucleolus;Cytoplasmic vesicle	NA	NA	NA	Belongs to the annexin family.	NA	PE1	4
+NX_Q9UJ78	Zinc finger MYM-type protein 5	669	74817	8.5	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Functions as a transcriptional regulator.	NA	NA	NA	PE1	13
+NX_Q9UJ83	2-hydroxyacyl-CoA lyase 1	578	63729	7.08	0	Nucleoplasm;Peroxisome;Cytoplasmic vesicle	NA	Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.	NA	Belongs to the TPP enzyme family.	Lipid metabolism; fatty acid metabolism.;Peroxisome;Alpha-oxidation of phytanate;Peroxisomal protein import	PE1	3
+NX_Q9UJ90	Potassium voltage-gated channel subfamily E regulatory beta subunit 5	142	14993	5.9	1	Membrane;Cytosol	Alport syndrome with mental retardation, midface hypoplasia and elliptocytosis	Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1.	NA	Belongs to the potassium channel KCNE family.	Phase 3 - rapid repolarisation;Phase 2 - plateau phase	PE1	X
+NX_Q9UJ94	Putative uncharacterized protein encoded by LINC00527	153	16537	6.04	0	NA	NA	NA	NA	NA	NA	PE5	21
+NX_Q9UJ96	Potassium voltage-gated channel subfamily G member 2	466	51240	9.33	6	Membrane	NA	Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.	NA	Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.	Voltage gated Potassium channels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	PE1	18
+NX_Q9UJ98	Cohesin subunit SA-3	1225	139034	5.23	0	Centromere;Nucleus;Chromosome	Premature ovarian failure 8	Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.	Phosphorylated.	Belongs to the SCC3 family.	Oocyte meiosis;Meiotic synapsis	PE1	7
+NX_Q9UJ99	Cadherin-22	828	89091	4.62	1	Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).	NA	NA	NA	PE1	20
+NX_Q9UJA2	Cardiolipin synthase (CMP-forming)	301	32593	9.73	5	Mitochondrion inner membrane	NA	Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.	NA	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Glycerophospholipid metabolism;Metabolic pathways;Acyl chain remodelling of PG;Synthesis of CL	PE1	20
+NX_Q9UJA3	DNA helicase MCM8	840	93697	7.82	0	Nucleoplasm;Nucleus;Chromosome	Premature ovarian failure 10	Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093).	NA	Belongs to the MCM family.	CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;Activation of ATR in response to replication stress;CDC6 association with the ORC:origin complex;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;E2F-enabled inhibition of pre-replication complex formation;Unwinding of DNA	PE1	20
+NX_Q9UJA5	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6	497	55799	7.18	0	Nucleoplasm;Cell junction;Nucleus	NA	Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297).	NA	Belongs to the TRM6/GCD10 family.	tRNA modification in the nucleus and cytosol	PE1	20
+NX_Q9UJA9	Ectonucleotide pyrophosphatase/phosphodiesterase family member 5	477	54666	5.94	1	Membrane;Nucleoplasm;Cytosol;Secreted	NA	Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication.	N-glycosylated.	Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.	NA	PE1	6
+NX_Q9UJC3	Protein Hook homolog 1	728	84648	5.09	0	Cytoplasm;Cytoskeleton	NA	Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622).	NA	Belongs to the hook family.	NA	PE1	1
+NX_Q9UJC5	SH3 domain-binding glutamic acid-rich-like protein 2	107	12326	6.3	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the SH3BGR family.	NA	PE1	6
+NX_Q9UJD0	Regulating synaptic membrane exocytosis protein 3	308	32796	9.38	0	Nucleolus;Mitochondrion;Synapse	NA	Regulates synaptic membrane exocytosis.	NA	NA	NA	PE1	1
+NX_Q9UJF2	Ras GTPase-activating protein nGAP	1139	128558	8.52	0	Focal adhesion;Cell membrane	NA	Inhibitory regulator of the Ras-cyclic AMP pathway.	NA	NA	Regulation of RAS by GAPs;Signaling by RAS mutants	PE1	1
+NX_Q9UJG1	Motile sperm domain-containing protein 1	213	24086	7.66	2	Cytoplasmic vesicle;Nucleoplasm;Endoplasmic reticulum membrane;Golgi apparatus membrane	NA	Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.	NA	NA	NA	PE1	X
+NX_Q9UJH8	Meteorin	293	31207	8.47	0	Nucleoplasm;Cytosol;Secreted;Nucleus membrane	NA	Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).	NA	Belongs to the meteorin family.	NA	PE1	16
+NX_Q9UJJ7	RNA pseudouridylate synthase domain-containing protein 1	312	34756	6.6	0	Golgi apparatus;Nucleoplasm;Cytosol;Cell junction	NA	NA	NA	Belongs to the pseudouridine synthase RluA family.	NA	PE1	16
+NX_Q9UJJ9	N-acetylglucosamine-1-phosphotransferase subunit gamma	305	33974	6.47	0	Golgi apparatus;Endoplasmic reticulum;Cytosol;Secreted	Mucolipidosis type III complementation group C	Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors.	Cys-245 mediates the formation of the interchain disulfide bond for formation of the homodimer. Cys-142, Cys-157 and Cys-169 are involved in intramolecular disulfide bonds formation (By similarity).	NA	Lysosome	PE1	16
+NX_Q9UJK0	Ribosome biogenesis protein TSR3 homolog	312	33596	6.48	0	Golgi apparatus;Cytosol	NA	Probable pre-rRNA processing protein involved in ribosome biogenesis.	NA	Belongs to the TSR3 family.	rRNA modification in the nucleus and cytosol	PE1	16
+NX_Q9UJL9	Zinc finger protein 69 homolog B	534	61481	9.23	0	Nucleoplasm;Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	1
+NX_Q9UJM3	ERBB receptor feedback inhibitor 1	462	50560	8.38	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).	NA	Belongs to the MIG6 family.	NA	PE1	1
+NX_Q9UJM8	Hydroxyacid oxidase 1	370	40924	8.2	0	Peroxisome	NA	Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.	NA	Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.	Organic acid metabolism; glycolate degradation; 3-phospho-D-glycerate from glycolate: step 1/4.;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Peroxisome;Glyoxylate metabolism and glycine degradation;Peroxisomal protein import	PE1	20
+NX_Q9UJN7	Zinc finger protein 391	358	40659	8.94	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	6
+NX_Q9UJP4	Kelch-like protein 21	597	66617	5.17	0	Spindle;Centrosome	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	1
+NX_Q9UJQ1	Lysosome-associated membrane glycoprotein 5	280	31472	5.99	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;Cell membrane;Endosome membrane;Recycling endosome;Growth cone membrane;Centriolar satellite;Cytoplasmic vesicle membrane;Synaptic vesicle membrane;Early endosome membrane;Cytosol;Spindle;Dendrite	NA	Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.	Glycosylated.	Belongs to the LAMP family.	NA	PE1	20
+NX_Q9UJQ4	Sal-like protein 4	1053	112231	7.2	0	Nucleoplasm;Cytoplasm;Nucleus	Oculootoradial syndrome;Duane-radial ray syndrome	Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.	Sumoylation with both SUMO1 and SUMO2 regulates the stability, subcellular localization, transcriptional activity, and may reduce interaction with POU5F1/OCT4.;Exists primarily as a ubiquitinated form.	Belongs to the sal C2H2-type zinc-finger protein family.	Transcriptional regulation of pluripotent stem cells;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;Regulation of PTEN gene transcription	PE1	20
+NX_Q9UJQ7	SCP2 sterol-binding domain-containing protein 1	156	17663	9.33	0	NA	NA	NA	NA	NA	NA	PE2	20
+NX_Q9UJS0	Calcium-binding mitochondrial carrier protein Aralar2	675	74176	8.79	6	Mitochondrion inner membrane;Mitochondrion	Citrullinemia 2;Cholestasis, neonatal intrahepatic, caused by citrin deficiency	Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane (PubMed:11566871, PubMed:25410934). May have a function in the urea cycle (PubMed:11566871).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Mitochondrial protein import;Gluconeogenesis;Aspartate and asparagine metabolism	PE1	7
+NX_Q9UJT0	Tubulin epsilon chain	475	52932	6.17	0	Centrosome	NA	NA	NA	Belongs to the tubulin family.	NA	PE1	6
+NX_Q9UJT1	Tubulin delta chain	453	51034	6.35	0	Cytoplasm;Centriole;Cilium;Nucleoplasm;Cytosol;Nucleus	NA	Acts as a positive regulator of hedgehog signaling and regulates ciliary function.	NA	Belongs to the tubulin family.	NA	PE1	17
+NX_Q9UJT2	Testis-specific serine kinase substrate	592	65050	5.7	0	Centriole	NA	May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.	Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK2.;TSKS is phosphorylated by TSSK2	NA	NA	PE1	19
+NX_Q9UJT9	F-box/LRR-repeat protein 7	491	54575	8.67	0	Centrosome	NA	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.	NA	Belongs to the FBXL7 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation	PE1	5
+NX_Q9UJU2	Lymphoid enhancer-binding factor 1	399	44201	6.9	0	Nucleoplasm;Nucleus	NA	Lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling.;Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells.;Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity).;Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.	Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway.	Belongs to the TCF/LEF family.	Wnt signaling pathway;Adherens junction;Melanogenesis;Pathways in cancer;Colorectal cancer;Endometrial cancer;Prostate cancer;Thyroid cancer;Basal cell carcinoma;Acute myeloid leukemia;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Formation of the beta-catenin:TCF transactivating complex;Ca2+ pathway;Deactivation of the beta-catenin transactivating complex;Binding of TCF/LEF:CTNNB1 to target gene promoters;Repression of WNT target genes;RUNX3 regulates WNT signaling;Transcriptional regulation of granulopoiesis	PE1	4
+NX_Q9UJU3	Zinc finger protein 112	913	105842	8.6	0	Centrosome;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9UJU5	Forkhead box protein D3	478	47630	6.01	0	Nucleus	Autoimmune disease 1	Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.	NA	NA	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	PE1	1
+NX_Q9UJU6	Drebrin-like protein	430	48207	5.02	0	Cell cortex;Cell membrane;Neuron projection;Early endosome;Perikaryon;Podosome;Golgi apparatus membrane;Lamellipodium;Nucleoplasm;Postsynaptic density;Synapse;Clathrin-coated vesicle membrane;Ruffle;Cytosol;Dendrite;Cytoskeleton	NA	Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.	Degraded by caspases during apoptosis.;DBNL is phosphorylated by BLK (Phosphotyrosine:PTM-0255)	Belongs to the ABP1 family.	Caspase-mediated cleavage of cytoskeletal proteins;Neurexins and neuroligins;Neutrophil degranulation	PE1	7
+NX_Q9UJV3	Probable E3 ubiquitin-protein ligase MID2	735	83210	7.24	0	Cytoplasm;Cytoskeleton	Mental retardation, X-linked 101	May play a role in microtubule stabilization.	Phosphorylated on serine and threonine residues.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.	PE1	X
+NX_Q9UJV8	Purine-rich element-binding protein gamma	347	39556	9.57	0	Nucleoplasm;Nucleus;Nucleolus;Cell membrane	NA	NA	NA	Belongs to the PUR DNA-binding protein family.	NA	PE1	8
+NX_Q9UJV9	Probable ATP-dependent RNA helicase DDX41	622	69838	6.4	0	Nucleoplasm;Nucleus;Nucleolus	Myeloproliferative/lymphoproliferative neoplasms, familial	Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.	NA	Belongs to the DEAD box helicase family. DDX41 subfamily.	STING mediated induction of host immune responses;Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN	PE1	5
+NX_Q9UJW0	Dynactin subunit 4	460	52337	7.1	0	Cell cortex;Sarcomere;Nucleoplasm;Stress fiber;Centrosome;Cytoskeleton	NA	Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.	NA	Belongs to the dynactin subunit 4 family.	Vasopressin-regulated water reabsorption;Huntington's disease;MHC class II antigen presentation;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	5
+NX_Q9UJW2	Tubulointerstitial nephritis antigen	476	54605	8.31	0	Basement membrane	NA	Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.	It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.	Belongs to the peptidase C1 family.	NA	PE1	6
+NX_Q9UJW3	DNA (cytosine-5)-methyltransferase 3-like	386	43583	5.59	0	Nucleus speckle;Nucleus	NA	Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327). Plays a key role in embryonic stem cells and germ cells (By similarity). In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity). Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (By similarity). While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity).	NA	NA	Cysteine and methionine metabolism;Metabolic pathways;DNA methylation	PE1	21
+NX_Q9UJW7	Zinc finger protein 229	825	93707	8.88	0	Cytoplasmic vesicle;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q9UJW8	Zinc finger protein 180	692	79111	8.04	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9UJW9	SERTA domain-containing protein 3	196	21769	4.56	0	Nucleus;Nucleolus	NA	Strong transcriptional coactivator.	NA	NA	NA	PE1	19
+NX_Q9UJX0	Oxidative stress-induced growth inhibitor 1	477	51992	6.63	0	Nucleoplasm;Cytosol	NA	Regulates the differentiation and proliferation through the regulation of cell death.	NA	Belongs to the OKL38 family.	NA	PE1	16
+NX_Q9UJX2	Cell division cycle protein 23 homolog	597	68834	6.59	0	Cytoplasm;Nucleus	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.	Belongs to the APC8/CDC23 family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	5
+NX_Q9UJX3	Anaphase-promoting complex subunit 7	599	66855	5.45	0	Nucleoplasm;Cytosol	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	NA	Belongs to the APC7 family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	12
+NX_Q9UJX4	Anaphase-promoting complex subunit 5	755	85077	6.4	0	Nucleoplasm	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	NA	Belongs to the APC5 family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	12
+NX_Q9UJX5	Anaphase-promoting complex subunit 4	808	92116	5.36	0	Cytoskeleton	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	NA	Belongs to the APC4 family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	4
+NX_Q9UJX6	Anaphase-promoting complex subunit 2	822	93828	5.12	0	Nucleoplasm	NA	Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.	NA	Belongs to the cullin family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	9
+NX_Q9UJY1	Heat shock protein beta-8	196	21604	5	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	Neuronopathy, distal hereditary motor, 2A;Charcot-Marie-Tooth disease 2L	Displays temperature-dependent chaperone activity.	NA	Belongs to the small heat shock protein (HSP20) family.	HSF1-dependent transactivation	PE1	12
+NX_Q9UJY4	ADP-ribosylation factor-binding protein GGA2	613	67150	6.13	0	Early endosome membrane;Golgi apparatus;trans-Golgi network membrane;Endosome membrane	NA	Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712).	Ubiquitinated.	Belongs to the GGA protein family.	Lysosome;Amyloid fiber formation;TBC/RABGAPs	PE1	16
+NX_Q9UJY5	ADP-ribosylation factor-binding protein GGA1	639	70384	5.18	0	Golgi apparatus;Endosome membrane;trans-Golgi network membrane;Nucleoplasm;Early endosome membrane;Cytoplasmic vesicle	NA	Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15886016, PubMed:15615712).	Ubiquitinated.;Phosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal DXXLL motif to bind the VHS domain and to inhibit the recognition of cargo signals.	Belongs to the GGA protein family.	Lysosome;Amyloid fiber formation;TBC/RABGAPs	PE1	22
+NX_Q9UJZ1	Stomatin-like protein 2, mitochondrial	356	38534	6.87	0	Mitochondrion;Cell membrane;Mitochondrion intermembrane space;Cytosol;Mitochondrion inner membrane;Membrane raft;Cytoskeleton	NA	Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.	Hyperphosphorylated at Ser-17 in some patients with monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia due to impaired dephosphorylation by PP2A.	Belongs to the band 7/mec-2 family.	Processing of SMDT1	PE1	9
+NX_Q9UK00	Uncharacterized protein C3orf18	162	17468	5.36	1	Membrane;Cytosol	NA	NA	NA	NA	NA	PE1	3
+NX_Q9UK05	Growth/differentiation factor 2	429	47320	6.03	0	Secreted	Telangiectasia, hereditary hemorrhagic, 5	Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.	A reversible disulfide bond can be formed between the two subunits in the homodimer; this has no effect on GDF2 activity.	Belongs to the TGF-beta family.	Signaling by BMP	PE1	10
+NX_Q9UK08	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	70	7841	6.55	0	Cell membrane	NA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NA	Belongs to the G protein gamma family.	Chemokine signaling pathway;Glutamatergic synapse;Cholinergic synapse;GABAergic synapse;Dopaminergic synapse;G alpha (i) signalling events;G alpha (q) signalling events;G alpha (s) signalling events;G beta:gamma signalling through PI3Kgamma;G alpha (12/13) signalling events;Activation of G protein gated Potassium channels;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;Glucagon signaling in metabolic regulation;G-protein activation;ADP signalling through P2Y purinoceptor 12;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;G beta:gamma signalling through PLC beta;ADP signalling through P2Y purinoceptor 1;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Extra-nuclear estrogen signaling;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42	PE1	19
+NX_Q9UK10	Zinc finger protein 225	706	82471	9.18	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9UK11	Zinc finger protein 223	482	55763	9.04	0	Nucleoplasm;Mitochondrion;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9UK12	Zinc finger protein 222	451	52484	8.96	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9UK13	Zinc finger protein 221	617	71197	8.8	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9UK17	Potassium voltage-gated channel subfamily D member 3	655	73451	8.56	6	Dendrite;Sarcolemma;Cell membrane	Brugada syndrome 9;Spinocerebellar ataxia 19	Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.	Regulated through phosphorylation at Ser-569 by CaMK2D.	Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily.	Voltage gated Potassium channels;Phase 1 - inactivation of fast Na+ channels	PE1	1
+NX_Q9UK22	F-box only protein 2	296	33328	4.29	0	Microsome membrane;Cytoplasm;Cytosol;Nucleoplasm	NA	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).	NA	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	1
+NX_Q9UK23	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	515	56073	6.15	1	Golgi stack membrane;trans-Golgi network	NA	Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases.	The precursor is cleaved and activated in the trans-Golgi network by a furin endopeptidase.	NA	Protein modification; protein glycosylation.;Lysosome	PE1	16
+NX_Q9UK28	Transmembrane protein 59-like	342	37619	6.11	1	Nucleoplasm;Cytoskeleton;Golgi apparatus membrane	NA	Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.	NA	Belongs to the TMEM59 family.	NA	PE1	19
+NX_Q9UK32	Ribosomal protein S6 kinase alpha-6	745	83872	5.92	0	Mitochondrion;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.	Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	MAPK signaling pathway;Oocyte meiosis;mTOR signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Progesterone-mediated oocyte maturation;Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation	PE1	X
+NX_Q9UK33	Zinc finger protein 580	172	18756	10.13	0	Nucleoplasm;Nucleus	NA	Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.	NA	NA	NA	PE1	19
+NX_Q9UK39	Nocturnin	431	48196	6.85	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Perinuclear region;Nucleus	NA	Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity).	NA	Belongs to the CCR4/nocturin family.	BMAL1:CLOCK,NPAS2 activates circadian gene expression	PE1	4
+NX_Q9UK41	Vacuolar protein sorting-associated protein 28 homolog	221	25425	5.37	0	Late endosome membrane;Cell membrane	NA	Component of the ESCRT-I complex, a regulator of vesicular trafficking process.	NA	Belongs to the VPS28 family.	Endocytosis;Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	8
+NX_Q9UK45	U6 snRNA-associated Sm-like protein LSm7	103	11602	5.1	0	Nucleus;Nucleolus	NA	Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).	NA	Belongs to the snRNP Sm proteins family.	RNA degradation;Spliceosome;mRNA Splicing - Major Pathway;mRNA decay by 5' to 3' exoribonuclease	PE1	19
+NX_Q9UK53	Inhibitor of growth protein 1	422	46738	9.28	0	Nucleoplasm;Cytosol;Nucleus	Squamous cell carcinoma of the head and neck	Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.	NA	Belongs to the ING family.	NA	PE1	13
+NX_Q9UK55	Protein Z-dependent protease inhibitor	444	50707	8.28	0	Nucleoplasm;Cytosol;Secreted	NA	Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.	Phosphorylated by FAM20C in the extracellular medium.	Belongs to the serpin family.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	14
+NX_Q9UK58	Cyclin-L1	526	59634	10.71	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).	NA	Belongs to the cyclin family. Cyclin L subfamily.	NA	PE1	3
+NX_Q9UK59	Lariat debranching enzyme	544	61555	5.25	0	Nucleoplasm;Nucleus	NA	Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis.	NA	Belongs to the lariat debranching enzyme family.	NA	PE1	3
+NX_Q9UK61	Protein TASOR	1670	189032	5.55	0	Nucleoplasm;Nucleus;Chromosome	NA	Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602).	NA	Belongs to the TASOR family.	NA	PE1	3
+NX_Q9UK73	Protein fem-1 homolog B	627	70264	6.14	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.	NA	Belongs to the fem-1 family.	Protein modification; protein ubiquitination.;Neddylation	PE1	15
+NX_Q9UK76	Jupiter microtubule associated homolog 1	154	16015	5.47	0	Cytoplasm;Nucleolus;Nucleus membrane;Nucleoplasm;Nucleus	NA	Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).	NA	Belongs to the JUPITER family.	NA	PE1	17
+NX_Q9UK80	Ubiquitin carboxyl-terminal hydrolase 21	565	62656	9.91	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).	NA	Belongs to the peptidase C19 family. USP21 subfamily.	TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases	PE1	1
+NX_Q9UK85	Dickkopf-like protein 1	242	27007	8.1	0	Secreted;Nucleus membrane;Endoplasmic reticulum;Cytoplasmic vesicle;Acrosome	NA	Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility.	N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm.	NA	NA	PE1	19
+NX_Q9UK96	F-box only protein 10	956	105195	8.47	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	9
+NX_Q9UK97	F-box only protein 9	447	52329	5.8	0	Cytoplasm;Centrosome;Cell membrane	NA	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	6
+NX_Q9UK99	F-box only protein 3	471	54561	4.88	0	Nucleoplasm;Cytosol;Nucleus	NA	Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.	NA	NA	NA	PE1	11
+NX_Q9UKA1	F-box/LRR-repeat protein 5	691	78555	5.32	0	Perinuclear region	NA	Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.	Polybiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Association of TriC/CCT with target proteins during biosynthesis;Iron uptake and transport;Neddylation	PE1	4
+NX_Q9UKA2	F-box/LRR-repeat protein 4	621	70097	6.1	0	Cytoplasm;Nucleus speckle;Nucleus;Mitochondrion	Mitochondrial DNA depletion syndrome 13	NA	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	6
+NX_Q9UKA4	A-kinase anchor protein 11	1901	210512	5.23	0	Cytoplasm;Cell membrane;Nucleolus;Centrosome;Cytosol	NA	Binds to type II regulatory subunits of protein kinase A and anchors/targets them.	NA	Belongs to the AKAP110 family.	NA	PE1	13
+NX_Q9UKA8	Calcipressin-3	241	27492	4.54	0	Nucleus speckle;Nucleolus	NA	Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).	NA	Belongs to the RCAN family.	NA	PE1	1
+NX_Q9UKA9	Polypyrimidine tract-binding protein 2	531	57491	8.72	0	Nucleoplasm;Nucleus	NA	Has a reduced affinity for RNA.;RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.	NA	NA	NA	PE1	1
+NX_Q9UKB1	F-box/WD repeat-containing protein 11	542	62091	6.73	0	Cytoplasmic vesicle;Nucleolus;Cytoplasm;Nucleus	NA	(Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.;Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262).	NA	NA	Oocyte meiosis;Ubiquitin mediated proteolysis;Wnt signaling pathway;Hedgehog signaling pathway;Circadian rhythm - mammal;Shigellosis;Activation of NF-kappaB in B cells;FCERI mediated NF-kB activation;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;NIK-->noncanonical NF-kB signaling;Antigen processing: Ubiquitination &amp; Proteasome degradation;Regulation of PLK1 Activity at G2/M Transition;Downstream TCR signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neddylation	PE1	5
+NX_Q9UKB3	DnaJ homolog subfamily C member 12	198	23415	5.51	0	Cytoplasm	Hyperphenylalaninemia, mild, non-BH4-deficient	NA	NA	NA	NA	PE1	10
+NX_Q9UKB5	Adherens junction-associated protein 1	411	44536	9.63	1	Basolateral cell membrane;Apical cell membrane;Adherens junction	NA	Plays a role in cell adhesion and cell migration.	Thr-237 and Ser-239 may be phosphorylated; however as this position is probably extracellular, the in vivo relevance is not proven.	NA	NA	PE1	1
+NX_Q9UKC9	F-box/LRR-repeat protein 2	423	47062	7.4	0	Membrane;Nucleoplasm;Nucleolus;Cell membrane	NA	Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).	NA	NA	NA	PE1	3
+NX_Q9UKD1	Glucocorticoid modulatory element-binding protein 2	530	56421	5.38	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.	NA	NA	NA	PE1	20
+NX_Q9UKD2	mRNA turnover protein 4 homolog	239	27560	8.34	0	Cytoplasm;Nucleus membrane;Nucleolus;Nucleoplasm;Nucleus	NA	Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	NA	Belongs to the universal ribosomal protein uL10 family.	NA	PE1	1
+NX_Q9UKE5	TRAF2 and NCK-interacting protein kinase	1360	154943	6.7	0	Cytoplasm;Recycling endosome;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Mental retardation, autosomal recessive 54	Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.	Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	Oxidative Stress Induced Senescence	PE1	3
+NX_Q9UKF2	Disintegrin and metalloproteinase domain-containing protein 30	790	88940	7.84	1	Late endosome membrane	NA	Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034).	NA	NA	Interaction With Cumulus Cells And The Zona Pellucida	PE1	1
+NX_Q9UKF5	Disintegrin and metalloproteinase domain-containing protein 29	820	92759	7.29	1	Membrane	NA	May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.	NA	NA	NA	PE1	4
+NX_Q9UKF6	Cleavage and polyadenylation specificity factor subunit 3	684	77486	5.37	0	Nucleus	NA	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity).	Sumoylated on Lys-462, Lys-465 and Lys-545, preferentially by SUMO3.	Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily.	mRNA surveillance pathway;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs;RNA Polymerase II Transcription Termination	PE1	2
+NX_Q9UKF7	Cytoplasmic phosphatidylinositol transfer protein 1	332	38388	5.99	0	Cytoplasm;Nucleoplasm;Cytosol	NA	Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro.	NA	Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily.	NA	PE1	17
+NX_Q9UKG1	DCC-interacting protein 13-alpha	709	79663	5.28	0	Cytoplasm;Endosome;Centrosome;Phagosome;Ruffle;Early endosome membrane;Spindle;Nucleus	Maturity-onset diabetes of the young 14	Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:26073777, PubMed:19661063, PubMed:10490823). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:26073777, PubMed:19661063, PubMed:24879834). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865).	Phosphorylation at Ser-410 by PKA severely impairs binding to OCRL.	NA	Pathways in cancer;Colorectal cancer;Caspase activation via Dependence Receptors in the absence of ligand	PE1	3
+NX_Q9UKG4	Solute carrier family 13 member 4	626	69358	7.16	12	Membrane	NA	Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).	NA	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.	Sodium-coupled sulphate, di- and tri-carboxylate transporters	PE1	7
+NX_Q9UKG9	Peroxisomal carnitine O-octanoyltransferase	612	70178	6.63	0	Peroxisome;Cytoplasmic vesicle	NA	Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.	NA	Belongs to the carnitine/choline acetyltransferase family.	Lipid metabolism; fatty acid beta-oxidation.;Peroxisome;Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import	PE1	7
+NX_Q9UKH3	Endogenous retrovirus group K member 9 Env polyprotein	698	79016	9.15	1	Virion;Cell membrane	NA	TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).;Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.;SU mediates receptor recognition.	Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.	Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.	NA	PE1	6
+NX_Q9UKI2	Cdc42 effector protein 3	254	27678	5.49	0	Endomembrane system;Cell membrane;Cytoskeleton	NA	Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.	CDC42EP3 is phosphorylated by MAPKAPK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the BORG/CEP family.	MAPK6/MAPK4 signaling	PE1	2
+NX_Q9UKI3	Pre-B lymphocyte protein 3	123	13710	5.1	0	NA	NA	Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.	NA	Belongs to the immunoglobulin superfamily.	Cell surface interactions at the vascular wall	PE1	22
+NX_Q9UKI8	Serine/threonine-protein kinase tousled-like 1	766	86700	8.88	0	Nucleoplasm;Nucleus	NA	Phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin.;Protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.;Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.	NA	PE1	2
+NX_Q9UKI9	POU domain, class 2, transcription factor 3	436	47432	8.66	0	Cell membrane;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.	NA	Belongs to the POU transcription factor family. Class-2 subfamily.	Herpes simplex infection	PE1	11
+NX_Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	227	25542	10.39	1	Membrane;Mitochondrion	NA	Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.	NA	NA	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	7
+NX_Q9UKJ1	Paired immunoglobulin-like type 2 receptor alpha	303	34005	10.22	1	Secreted;Cell membrane	NA	Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.;(Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.	Phosphorylated on tyrosine residues.;According to PubMed:10660620, N- and O-glycosylated. According to PubMed:10903717, only N-glycosylated.	NA	Herpes simplex infection;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	7
+NX_Q9UKJ3	G patch domain-containing protein 8	1502	164197	8.81	0	Nucleus speckle;Mitochondrion	NA	NA	NA	NA	NA	PE1	17
+NX_Q9UKJ5	Cysteine-rich hydrophobic domain-containing protein 2	165	19254	6.34	0	Cytoplasmic vesicle;Cell membrane	NA	NA	Palmitoylation in the CHIC motif is required for membrane association.	Belongs to the CHIC family.	NA	PE1	4
+NX_Q9UKJ8	Disintegrin and metalloproteinase domain-containing protein 21	722	80834	6.22	1	Membrane	NA	May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients.	Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated.	NA	Interaction With Cumulus Cells And The Zona Pellucida	PE1	14
+NX_Q9UKK3	Protein mono-ADP-ribosyltransferase PARP4	1724	192595	5.43	0	Cytoplasm;Cytosol;Spindle;Nucleus	NA	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.	NA	NA	Base excision repair;Nicotinamide salvaging	PE1	13
+NX_Q9UKK6	NTF2-related export protein 1	140	15847	4.91	0	Cytoplasm;Nucleus speckle;Nucleoplasm;Cytosol;Nucleus	NA	Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).	NA	NA	Ribosome biogenesis in eukaryotes;RNA transport;mRNA surveillance pathway;Influenza A;Transport of Mature mRNA derived from an Intron-Containing Transcript	PE1	20
+NX_Q9UKK9	ADP-sugar pyrophosphatase	219	24328	4.87	0	Nucleoplasm;Centrosome;Nucleus;Cytoplasmic vesicle	NA	Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity).	Phosphorylation at Thr-45 is required for homodimer stability; dephosphorylation results in destabilization of the homodimer. Dephosphorylation at Thr-45 promotes the ATP-synthesis activity.	Belongs to the Nudix hydrolase family.	Purine metabolism;Phosphate bond hydrolysis by NUDT proteins	PE1	10
+NX_Q9UKL0	REST corepressor 1	485	53327	6.56	0	Nucleoplasm;Nucleus	NA	Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.	Phosphorylated by HSV-1 protein kinases in case of infection.	Belongs to the CoREST family.	Huntington's disease;Factors involved in megakaryocyte development and platelet production;HDACs deacetylate histones;Regulation of PTEN gene transcription	PE1	14
+NX_Q9UKL2	Olfactory receptor 52A1	312	35322	8.89	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9UKL3	CASP8-associated protein 2	1982	222658	6.14	0	Cytoplasm;Mitochondrion;Nucleolus;PML body;Nucleus	NA	Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.	NA	NA	SUMOylation of transcription cofactors	PE1	6
+NX_Q9UKL4	Gap junction delta-2 protein	321	36093	8.95	4	Gap junction;Cell membrane	NA	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NA	Belongs to the connexin family. Delta-type subfamily.	Gap junction;Electric Transmission Across Gap Junctions;Gap junction assembly	PE1	15
+NX_Q9UKL6	Phosphatidylcholine transfer protein	214	24843	5.62	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.	NA	NA	Synthesis of PC;Mitochondrial Fatty Acid Beta-Oxidation	PE1	17
+NX_Q9UKM7	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	699	79580	7.38	1	Cytoplasmic vesicle;Endoplasmic reticulum membrane	Mental retardation, autosomal recessive 15	Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).	NA	Belongs to the glycosyl hydrolase 47 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum;Defective MAN1B1 causes MRT15;ER Quality Control Compartment (ERQC)	PE1	9
+NX_Q9UKM9	RNA-binding protein Raly	306	32463	9.2	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072).	NA	Belongs to the RRM HNRPC family. RALY subfamily.	NA	PE1	20
+NX_Q9UKN1	Mucin-12	5478	558164	5.31	1	Membrane	NA	Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium.	NA	NA	O-linked glycosylation of mucins;Termination of O-glycan biosynthesis;Dectin-2 family;Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1)	PE1	7
+NX_Q9UKN5	PR domain zinc finger protein 4	801	87920	5.93	0	Nucleoplasm;Nucleus	NA	May function as a transcription factor involved in cell differentiation.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	p75NTR negatively regulates cell cycle via SC1	PE1	12
+NX_Q9UKN7	Unconventional myosin-XV	3530	395293	9.26	0	Stereocilium;Cytoskeleton	Deafness, autosomal recessive, 3	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	NA	PE1	17
+NX_Q9UKN8	General transcription factor 3C polypeptide 4	822	91982	6.21	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.	NA	Belongs to the TFIIIC subunit 4 family.	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter	PE1	9
+NX_Q9UKP3	Integrin beta-1-binding protein 2	347	38382	5.04	0	Cytosol	NA	May play a role during maturation and/or organization of muscles cells.	NA	NA	NA	PE1	X
+NX_Q9UKP4	A disintegrin and metalloproteinase with thrombospondin motifs 7	1686	184095	5.81	0	Cytoplasmic vesicle;Extracellular matrix	NA	Metalloprotease that may play a role in the degradation of COMP.	May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed.;N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan. Contains chondroitin sulfate.	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	15
+NX_Q9UKP5	A disintegrin and metalloproteinase with thrombospondin motifs 6	1117	125273	6.24	0	Extracellular matrix	NA	NA	The precursor is cleaved by a furin endopeptidase.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	5
+NX_Q9UKP6	Urotensin-2 receptor	389	42130	10.68	7	Cell membrane	NA	High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;Peptide ligand-binding receptors;G alpha (q) signalling events	PE1	17
+NX_Q9UKQ2	Disintegrin and metalloproteinase domain-containing protein 28	775	87148	6.55	1	Mitochondrion;Secreted;Cell membrane	NA	May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.	Pro-domain removal and maturation may be, at least in part, autocatalytic.	NA	NA	PE1	8
+NX_Q9UKQ9	Kallikrein-9	250	27513	7.1	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family. Kallikrein subfamily.	NA	PE1	19
+NX_Q9UKR0	Kallikrein-12	248	26734	7.57	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family. Kallikrein subfamily.	Formation of the cornified envelope	PE1	19
+NX_Q9UKR3	Kallikrein-13	277	30570	8.78	0	Secreted	NA	NA	NA	Belongs to the peptidase S1 family. Kallikrein subfamily.	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Formation of the cornified envelope	PE1	19
+NX_Q9UKR5	Probable ergosterol biosynthetic protein 28	140	15864	9.86	4	Nucleoplasm;Endoplasmic reticulum;Cytosol;Endoplasmic reticulum membrane	NA	NA	NA	Belongs to the ERG28 family.	NA	PE1	14
+NX_Q9UKR8	Tetraspanin-16	245	26266	8.61	4	Membrane	NA	NA	NA	Belongs to the tetraspanin (TM4SF) family.	NA	PE1	19
+NX_Q9UKS6	Protein kinase C and casein kinase substrate in neurons protein 3	424	48487	5.83	0	Cytoplasm;Cytosol;Cell membrane	NA	Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).	Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).	Belongs to the PACSIN family.	Clathrin-mediated endocytosis	PE1	11
+NX_Q9UKS7	Zinc finger protein Helios	526	59574	6.3	0	Nucleoplasm;Cytosol;Nucleus	NA	Associates with Ikaros at centromeric heterochromatin.	NA	Belongs to the Ikaros C2H2-type zinc-finger protein family.	NA	PE1	2
+NX_Q9UKT4	F-box only protein 5	447	50146	9.17	0	Spindle;Nucleoplasm;Cytoplasm;Nucleus	NA	Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:29875408, PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment (PubMed:29875408). As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities (PubMed:23708605, PubMed:23708001, PubMed:16921029). Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence (PubMed:17234884, PubMed:17485488, PubMed:17875940). During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity). Promotes migration and osteogenic differentiation of mesenchymal stem cells (PubMed:29850565).	Phosphorylation by CDK2 and subsequently by PLK1 triggers degradation during early mitosis through ubiquitin-mediated proteolysis by the SCF ubiquitin ligase complex containing the F-box protein BTRC. This degradation is necessary for the activation of APC in late mitosis and subsequent mitotic progression (PubMed:12791267, PubMed:15469984). Phosphorylated by RPS6KA2; increases and stabilizes interaction with CDC20 (By similarity).;Ubiquitinated by the SCF(BTRC) complex following phosphorylation by PLK1 (PubMed:15469984). Undergoes both 'Lys-11' and 'Lys-48'-linked polyubiquitination by APC-FZR1 complex leading to degradation by proteasome during G1 phase (PubMed:29875408). Degraded through the SCF(BTRC) complex; degradation occurs during oocyte maturation, between germinal vesicle breakdown (GVBD) and meiosis I, and is required for the meiosis I-meiosis II transition (By similarity).	NA	Protein modification; protein ubiquitination.;Oocyte meiosis;SCF-beta-TrCP mediated degradation of Emi1;G1/S-Specific Transcription;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of Emi1;Mitotic Metaphase/Anaphase Transition	PE1	6
+NX_Q9UKT5	F-box only protein 4	387	44136	5.77	0	Nucleoplasm;Cytoplasm	NA	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.	Phosphorylation at Ser-12 varies during the cell cycle. It is low in resting cells and high in the S phase and the G2/M phase of the cell cycle. Phosphorylation is decreased during late G1 phase (By similarity). Phosphorylation at Ser-12 promotes homodimerization and is necessary for optimal ubiquitin ligase activity towards CCND1.	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Antigen processing: Ubiquitination &amp; Proteasome degradation;Association of TriC/CCT with target proteins during biosynthesis;Neddylation	PE1	5
+NX_Q9UKT6	Putative F-box/LRR-repeat protein 21	434	49152	6.02	0	Cytosol;Nucleus	NA	Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE5	5
+NX_Q9UKT7	F-box/LRR-repeat protein 3	428	48707	6.41	0	Cytoplasm;Nucleus	Intellectual developmental disorder with short stature, facial anomalies, and speech defects	Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).	Undergoes autophagy-mediated degradation in the liver in a time-dependent manner.	NA	Protein modification; protein ubiquitination.;Circadian rhythm - mammal;Antigen processing: Ubiquitination &amp; Proteasome degradation;Association of TriC/CCT with target proteins during biosynthesis;Circadian Clock;Neddylation	PE1	13
+NX_Q9UKT8	F-box/WD repeat-containing protein 2	454	51512	6.11	0	Nucleoplasm	NA	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.	NA	NA	Antigen processing: Ubiquitination &amp; Proteasome degradation;Association of TriC/CCT with target proteins during biosynthesis;Neddylation	PE1	9
+NX_Q9UKT9	Zinc finger protein Aiolos	509	58023	6.11	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.	Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.	Belongs to the Ikaros C2H2-type zinc-finger protein family.	NA	PE1	17
+NX_Q9UKU0	Long-chain-fatty-acid--CoA ligase 6	697	77752	7.2	1	Mitochondrion outer membrane;Peroxisome membrane;Microsome membrane;Endoplasmic reticulum membrane	NA	Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Fatty acid metabolism;Metabolic pathways;PPAR signaling pathway;Peroxisome;Adipocytokine signaling pathway;Synthesis of very long-chain fatty acyl-CoAs	PE1	5
+NX_Q9UKU6	Thyrotropin-releasing hormone-degrading ectoenzyme	1024	117000	6.51	1	Membrane	NA	Specific inactivation of TRH after its release.	NA	Belongs to the peptidase M1 family.	NA	PE1	12
+NX_Q9UKU7	Isobutyryl-CoA dehydrogenase, mitochondrial	415	45070	8.12	0	Mitochondrion	Isobutyryl-CoA dehydrogenase deficiency	Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway (PubMed:11013134, PubMed:12359132, PubMed:16857760). To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA (PubMed:11013134, PubMed:12359132).	NA	Belongs to the acyl-CoA dehydrogenase family.	Amino-acid degradation; L-valine degradation.;Valine, leucine and isoleucine degradation;Metabolic pathways;Branched-chain amino acid catabolism	PE1	11
+NX_Q9UKU9	Angiopoietin-related protein 2	493	57104	7.23	0	Golgi apparatus;Secreted	NA	Induces sprouting in endothelial cells through an autocrine and paracrine action.	N-glycosylated.	NA	NA	PE1	9
+NX_Q9UKV0	Histone deacetylase 9	1011	111297	6.4	0	Nucleoplasm;Nucleus	NA	Lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.;Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.	Is phosphorylated on Tyr-1010. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import.;Sumoylated.;Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240; which impairs nuclear accumulation (By similarity).	Belongs to the histone deacetylase family. HD type 2 subfamily.	Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	PE1	7
+NX_Q9UKV3	Apoptotic chromatin condensation inducer in the nucleus	1341	151862	6.08	0	Nucleus speckle;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.	Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.;Phosphorylation on Ser-1180 by SRPK2 up-regulates its stimulatory effect on cyclin A1.;ACIN1 is phosphorylated by SRPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	RNA transport;mRNA surveillance pathway;Spliceosome;Apoptotic cleavage of cellular proteins	PE1	14
+NX_Q9UKV5	E3 ubiquitin-protein ligase AMFR	643	72996	5.95	7	Endoplasmic reticulum;Golgi apparatus;Endoplasmic reticulum membrane	NA	E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040).	Palmitoylation of the RING-type zing finger by ZDHHC6 promotes localization to the peripheral endoplasmic reticulum.	NA	Protein modification; protein ubiquitination.;Protein processing in endoplasmic reticulum;ER Quality Control Compartment (ERQC);N-glycan trimming in the ER and Calnexin/Calreticulin cycle	PE1	16
+NX_Q9UKV8	Protein argonaute-2	859	97208	9.32	0	Nucleoplasm;P-body;Cell junction;Nucleus	NA	Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.	Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity.	Belongs to the argonaute family. Ago subfamily.	MAPK6/MAPK4 signaling;Transcriptional regulation by small RNAs;MicroRNA (miRNA) biogenesis;Pre-NOTCH Transcription and Translation;Small interfering RNA (siRNA) biogenesis;TP53 Regulates Metabolic Genes;Ca2+ pathway;Post-transcriptional silencing by small RNAs;Regulation of RUNX1 Expression and Activity;Regulation of PTEN mRNA translation;Competing endogenous RNAs (ceRNAs) regulate PTEN translation;Estrogen-dependent gene expression;Transcriptional Regulation by MECP2;Regulation of MECP2 expression and activity	PE1	8
+NX_Q9UKW4	Guanine nucleotide exchange factor VAV3	847	97776	6.65	0	NA	NA	Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).	Phosphorylated. Phosphorylation can be mediated by ROS1. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1 (By similarity).;VAV3 is phosphorylated by ROS1 (Phosphotyrosine:PTM-0255)	NA	Chemokine signaling pathway;Focal adhesion;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Regulation of actin dynamics for phagocytic cup formation;GPVI-mediated activation cascade;EPH-ephrin mediated repulsion of cells;Rho GTPase cycle;NRAGE signals death through JNK;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;G alpha (12/13) signalling events;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability	PE1	1
+NX_Q9UKW6	ETS-related transcription factor Elf-5	265	31263	5.81	0	Nucleoplasm;Nucleus	NA	Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.;Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.	NA	Belongs to the ETS family.	NA	PE1	11
+NX_Q9UKX2	Myosin-2	1941	223044	5.64	0	Cytoplasm;Myofibril	Myopathy, proximal, and ophthalmoplegia	Muscle contraction. Required for cytoskeleton organization (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tight junction;Viral myocarditis;Regulation of actin dynamics for phagocytic cup formation	PE1	17
+NX_Q9UKX3	Myosin-13	1938	223605	5.54	0	Myofibril	NA	Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tight junction;Viral myocarditis	PE1	17
+NX_Q9UKX5	Integrin alpha-11	1188	133470	6.24	1	Membrane	NA	Integrin alpha-11/beta-1 is a receptor for collagen.	NA	Belongs to the integrin alpha chain family.	Focal adhesion;ECM-receptor interaction;Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Integrin cell surface interactions	PE1	15
+NX_Q9UKX7	Nuclear pore complex protein Nup50	468	50144	6.64	0	Nucleoplasm;Nucleus membrane;Nuclear pore complex	NA	Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity).	NA	NA	RNA transport;ISG15 antiviral mechanism;Rev-mediated nuclear export of HIV RNA;Viral Messenger RNA Synthesis;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;SUMOylation of DNA damage response and repair proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;Transcriptional regulation by small RNAs;snRNP Assembly;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Transport of Ribonucleoproteins into the Host Nucleus;NEP/NS2 Interacts with the Cellular Export Machinery;NS1 Mediated Effects on Host Pathways;tRNA processing in the nucleus;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of chromatin organization proteins;SUMOylation of ubiquitinylation proteins;SUMOylation of SUMOylation proteins	PE1	22
+NX_Q9UKY0	Prion-like protein doppel	176	20293	9.24	0	Cell membrane	NA	Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (PubMed:15218028, PubMed:20411530).	O-glycosylated.;N-glycosylated. N-glycosylated at two distinct sites.	Belongs to the prion family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	20
+NX_Q9UKY1	Zinc fingers and homeoboxes protein 1	873	98098	5.76	0	Nucleoplasm;Nucleus	NA	Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.	NA	Belongs to the ZHX family.	NA	PE1	8
+NX_Q9UKY3	Putative inactive carboxylesterase 4	287	30679	7.83	0	Secreted	NA	Has no esterase activity.	NA	Belongs to the type-B carboxylesterase/lipase family.	NA	PE5	16
+NX_Q9UKY4	Protein O-mannosyl-transferase 2	750	84214	9.25	10	Endoplasmic reticulum membrane	Muscular dystrophy-dystroglycanopathy congenital with mental retardation B2;Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A2;Muscular dystrophy-dystroglycanopathy limb-girdle C2	Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:14699049, PubMed:28512129). Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129).	N-glycosylated.	Belongs to the glycosyltransferase 39 family.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2;O-linked glycosylation;Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	PE1	14
+NX_Q9UKY7	Protein CDV3 homolog	258	27335	6.06	0	Cytoplasm;Cytosol;Nucleolus;Cell membrane	NA	NA	NA	Belongs to the CDV3 family.	NA	PE1	3
+NX_Q9UKZ1	CCR4-NOT transcription complex subunit 11	510	55215	5.99	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.	NA	Belongs to the CNOT11 family.	Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	2
+NX_Q9UKZ4	Teneurin-1	2725	305011	5.98	1	Cytoplasm;Nucleus speckle;Cell membrane;Nucleus matrix;Nucleus;Cytoskeleton	NA	Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).;Ten-1 intracellular domain: Induces gene transcription activation.;Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity).	Teneurin C-terminal-associated peptide: Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may be generated (By similarity).	Belongs to the tenascin family. Teneurin subfamily.	NA	PE1	X
+NX_Q9UKZ9	Procollagen C-endopeptidase enhancer 2	415	45717	8.81	0	Nucleoplasm;Cytosol;Secreted	NA	Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.	O-glycosylated; contains sialic acid.	NA	Collagen biosynthesis and modifying enzymes	PE1	3
+NX_Q9UL01	Dermatan-sulfate epimerase	958	109773	8.23	2	Membrane;Nucleoplasm;Cytosol	Ehlers-Danlos syndrome, musculocontractural type 2	Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues.	NA	Belongs to the dermatan-sulfate isomerase family.	Glycan metabolism; chondroitin sulfate biosynthesis.;Glycan metabolism; heparan sulfate biosynthesis.;Glycosaminoglycan biosynthesis - chondroitin sulfate;Dermatan sulfate biosynthesis	PE1	6
+NX_Q9UL03	Integrator complex subunit 6	887	100390	8.79	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144).	NA	Belongs to the Integrator subunit 6 family.	RNA polymerase II transcribes snRNA genes	PE1	13
+NX_Q9UL12	Sarcosine dehydrogenase, mitochondrial	918	101037	6.8	0	Mitochondrion matrix;Mitochondrion	Sarcosinemia	NA	NA	Belongs to the GcvT family.	Amine and polyamine degradation; sarcosine degradation; formaldehyde and glycine from sarcosine: step 1/1.;Glycine, serine and threonine metabolism;Metabolic pathways;Choline catabolism	PE1	9
+NX_Q9UL15	BAG family molecular chaperone regulator 5	447	51200	5.76	0	Cytoplasmic vesicle	NA	Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.	NA	NA	Regulation of HSF1-mediated heat shock response	PE1	14
+NX_Q9UL16	Cilia- and flagella-associated protein 45	551	65730	8.94	0	Nucleoplasm;Cilium	NA	NA	NA	Belongs to the CFAP45 family.	NA	PE1	1
+NX_Q9UL17	T-box transcription factor TBX21	535	58328	5.67	0	Nucleus	Asthma, with nasal polyps and aspirin intolerance	Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity).	Ubiquitinated at Lys-314, leading to its degradation by the proteasome. Ubiquitination is essential for controlling protein stability, binding to the T-box-binding element of the IFN-gamma promoter, and for interaction with NFATC2 through induction of phosphorylation at Thr-303 (By similarity). Deubiquitinated by USP10 leading to its stabilization (PubMed:24845384).;Phosphorylations at Ser-53, Tyr-77, Ser-225 and Ser-513 are regulated by mTORC1. Phosphorylation at Tyr-530 is essential for its interaction GATA3. Phosphorylation at Tyr-220, Tyr-266 and Tyr-305 enhances its transcriptional activator activity. Phosphorylation at Thr-303 is required for its interaction with NFATC2.	NA	NA	PE1	17
+NX_Q9UL18	Protein argonaute-1	857	97214	9.27	0	P-body	NA	Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).	NA	Belongs to the argonaute family. Ago subfamily.	MAPK6/MAPK4 signaling;Transcriptional regulation by small RNAs;Oxidative Stress Induced Senescence;MicroRNA (miRNA) biogenesis;Pre-NOTCH Transcription and Translation;Small interfering RNA (siRNA) biogenesis;TP53 Regulates Metabolic Genes;Ca2+ pathway;Post-transcriptional silencing by small RNAs;Oncogene Induced Senescence;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of RUNX1 Expression and Activity;Regulation of PTEN mRNA translation;Competing endogenous RNAs (ceRNAs) regulate PTEN translation;Estrogen-dependent gene expression;Transcriptional Regulation by MECP2;Regulation of MECP2 expression and activity	PE1	1
+NX_Q9UL19	Phospholipase A and acyltransferase 4	164	18179	8.78	1	Membrane	NA	Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). Promotes keratinocyte differentiation via activation of TGM1 (PubMed:17762858).	NA	Belongs to the H-rev107 family.	Acyl chain remodelling of PE	PE1	11
+NX_Q9UL25	Ras-related protein Rab-21	225	24348	8.11	0	trans-Golgi network;Endoplasmic reticulum membrane;Cleavage furrow;Cytoplasmic vesicle membrane;Endosome;Golgi apparatus membrane;Early endosome membrane;Neuron projection	NA	Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148).	NA	Belongs to the small GTPase superfamily. Rab family.	RAB GEFs exchange GTP for GDP on RABs;RAB geranylgeranylation	PE1	12
+NX_Q9UL26	Ras-related protein Rab-22A	194	21855	8.32	0	Endosome membrane;Cell membrane;Phagosome membrane;Early endosome;Centrosome;Phagosome;Late endosome;Ruffle;Cytoplasmic vesicle	NA	Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905).	NA	Belongs to the small GTPase superfamily. Rab family.	Endocytosis;RAB geranylgeranylation	PE1	20
+NX_Q9UL33	Trafficking protein particle complex subunit 2-like protein	140	16146	6.28	0	Golgi apparatus;Endoplasmic reticulum;Cytoplasmic vesicle;Cytosol;Perinuclear region	Encephalopathy, progressive, early-onset, with episodic rhabdomyolysis	Plays a role in vesicular transport from endoplasmic reticulum to Golgi.	NA	Belongs to the TRAPP small subunits family. Sedlin subfamily.	COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs	PE1	16
+NX_Q9UL36	Zinc finger protein 236	1845	203704	8.46	0	Nucleoplasm;Cytosol;Cell junction;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	18
+NX_Q9UL40	Zinc finger protein 346	294	32933	9.24	0	Cytoplasm;Nucleolus	NA	Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053). May bind to specific miRNA hairpins (PubMed:28431233).	NA	NA	NA	PE1	5
+NX_Q9UL41	Paraneoplastic antigen Ma3	463	52376	9.59	0	Nucleolus;Nucleus	NA	NA	NA	Belongs to the PNMA family.	NA	PE1	X
+NX_Q9UL42	Paraneoplastic antigen Ma2	364	41509	4.84	0	Nucleolus	NA	NA	NA	Belongs to the PNMA family.	NA	PE1	8
+NX_Q9UL45	Biogenesis of lysosome-related organelles complex 1 subunit 6	172	19744	6.01	0	Membrane;Cytoplasm	Hermansky-Pudlak syndrome 9	Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.	Phosphorylated.	Belongs to the BLOC1S6 family.	Golgi Associated Vesicle Biogenesis	PE1	15
+NX_Q9UL46	Proteasome activator complex subunit 2	239	27402	5.54	0	Nucleoplasm	NA	Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.	NA	Belongs to the PA28 family.	Proteasome;Antigen processing and presentation;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	14
+NX_Q9UL49	Transcription factor-like 5 protein	500	52697	6.44	0	Nucleoplasm;Nucleus	NA	Putative transcription factor.;May play a role in early spermatogenesis.	NA	NA	NA	PE1	20
+NX_Q9UL51	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	889	96950	9.15	6	Cell membrane	NA	Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).	Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating.	Belongs to the potassium channel HCN family.	HCN channels	PE1	19
+NX_Q9UL52	Transmembrane protease serine 11E	423	47696	8.85	1	Secreted;Cell membrane	NA	Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.	N-glycosylated.	Belongs to the peptidase S1 family.	NA	PE1	4
+NX_Q9UL54	Serine/threonine-protein kinase TAO2	1235	138251	6.84	5	Nucleolus;Nucleoplasm;Cytoplasmic vesicle membrane;Cytosol;Dendrite;Nucleus;Cytoskeleton	NA	Binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway.;But not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway.;But not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.;Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases.	Autophosphorylated. Phosphorylated by ATM.;C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity.;Isoforms 1 and 2 are autophosphorylated.;Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By similarity).	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	MAPK signaling pathway	PE1	16
+NX_Q9UL58	Zinc finger protein 215	517	60034	8.96	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	11
+NX_Q9UL59	Zinc finger protein 214	606	70992	8.84	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	11
+NX_Q9UL62	Short transient receptor potential channel 5	973	111412	6.94	6	Cell membrane	NA	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.	NA	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.	TRP channels;Role of second messengers in netrin-1 signaling	PE1	X
+NX_Q9UL63	Muskelin	735	84768	5.91	0	Cytoplasm;Cell cortex;Cell membrane;Nucleoplasm;Synapse;Ruffle;Cytoplasmic vesicle;Cytosol	NA	Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (PubMed:18710924).	NA	NA	NA	PE1	7
+NX_Q9UL68	Myelin transcription factor 1-like protein	1186	133043	4.86	0	Cytoplasmic vesicle;Nucleus;Chromosome	Mental retardation, autosomal dominant 39	Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.	NA	Belongs to the MYT1 family.	NA	PE1	2
+NX_Q9ULA0	Aspartyl aminopeptidase	475	52428	7.03	0	Cytoplasm;Cytosol	NA	Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.	NA	Belongs to the peptidase M18 family.	NA	PE1	2
+NX_Q9ULB1	Neurexin-1	1477	161883	5.61	1	Presynaptic cell membrane;Cell membrane	Schizophrenia 17;Pitt-Hopkins-like syndrome 2	Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).	N-glycosylated.;O-glycosylated.;NRXN1 is phosphorylated by CASK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the neurexin family.	Cell adhesion molecules (CAMs);Non-integrin membrane-ECM interactions;Neurexins and neuroligins	PE1	2
+NX_Q9ULB4	Cadherin-9	789	88689	4.73	1	Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	Adherens junctions interactions	PE1	5
+NX_Q9ULB5	Cadherin-7	785	87086	4.64	1	Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	Adherens junctions interactions	PE1	18
+NX_Q9ULC0	Endomucin	261	27452	7.72	1	Membrane;Secreted;Cell membrane	NA	Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.	Highly O-glycosylated. Sialic acid-rich glycoprotein.	NA	NA	PE1	4
+NX_Q9ULC3	Ras-related protein Rab-23	237	26659	6.22	0	Cytoplasm;Cell membrane;Endosome membrane;Phagosome membrane;Autophagosome;Phagosome;Cytosol	Carpenter syndrome 1	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.	NA	Belongs to the small GTPase superfamily. Rab family.	Hedgehog signaling pathway;RAB geranylgeranylation	PE1	6
+NX_Q9ULC4	Malignant T-cell-amplified sequence 1	181	20555	8.98	0	Cytoplasm;Cytosol;Cell membrane	NA	Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.	Phosphorylation is critical for stabilization and promotion of cell proliferation.	Belongs to the MCTS1 family.	NA	PE1	X
+NX_Q9ULC5	Long-chain-fatty-acid--CoA ligase 5	683	75991	6.49	1	Mitochondrion outer membrane;Mitochondrion;Endoplasmic reticulum membrane;Cell membrane;Nucleoplasm;Endoplasmic reticulum	NA	Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Fatty acid metabolism;Metabolic pathways;PPAR signaling pathway;Peroxisome;Adipocytokine signaling pathway;Synthesis of very long-chain fatty acyl-CoAs	PE1	10
+NX_Q9ULC6	Protein-arginine deiminase type-1	663	74666	6.07	0	Nucleoplasm;Cytosol;Cytoplasm	NA	Catalyzes the deimination of arginine residues of proteins.	NA	Belongs to the protein arginine deiminase family.	Chromatin modifying enzymes	PE1	1
+NX_Q9ULC8	Probable palmitoyltransferase ZDHHC8	765	81443	9.33	4	Nucleoplasm;Cytosol;Cytoplasmic vesicle membrane	NA	Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.	NA	Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.	HDL assembly	PE1	22
+NX_Q9ULD0	2-oxoglutarate dehydrogenase-like, mitochondrial	1010	114481	6.18	0	Mitochondrion matrix;Nucleolus	NA	NA	NA	Belongs to the alpha-ketoglutarate dehydrogenase family.	Citrate cycle (TCA cycle);Lysine degradation;Tryptophan metabolism;Metabolic pathways	PE1	10
+NX_Q9ULD2	Microtubule-associated tumor suppressor 1	1270	141397	7.33	0	Golgi apparatus;Mitochondrion;Cell membrane;Nucleolus;Centrosome;Spindle;Nucleus;Cytoskeleton	Hepatocellular carcinoma	Inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.;Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation.	NA	Belongs to the MTUS1 family.	NA	PE1	8
+NX_Q9ULD4	Bromodomain and PHD finger-containing protein 3	1205	135745	6.17	0	Nucleoplasm;Mitochondrion	NA	Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.	NA	NA	HATs acetylate histones;Platelet degranulation;Regulation of TP53 Activity through Acetylation	PE1	6
+NX_Q9ULD5	Zinc finger protein 777	831	93762	6.16	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q9ULD6	Protein inturned	942	105648	5.59	0	Cell surface;Cytoplasm;Cilium basal body;Cytoplasmic vesicle	Short-rib thoracic dysplasia 20 with polydactyly;Orofaciodigital syndrome 17;Short-rib thoracic dysplasia 7/20 with polydactyly, digenic	Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779).	NA	Belongs to the inturned family.	Hedgehog 'off' state	PE1	4
+NX_Q9ULD8	Potassium voltage-gated channel subfamily H member 3	1083	117129	8.25	6	Membrane;Nucleoplasm;Mitochondrion	NA	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.	NA	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily.	Voltage gated Potassium channels	PE1	12
+NX_Q9ULD9	Zinc finger protein 608	1512	162208	8.92	0	Nucleoplasm;Mitochondrion	NA	Transcription factor, which represses ZNF609 transcription.	NA	NA	NA	PE1	5
+NX_Q9ULE0	Protein WWC3	1092	122676	6	0	Cytosol;Cytoskeleton	NA	NA	NA	Belongs to the WWC family.	NA	PE1	X
+NX_Q9ULE3	DENN domain-containing protein 2A	1009	113853	9.11	0	Cytoskeleton	NA	Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport.	NA	NA	RAB GEFs exchange GTP for GDP on RABs	PE1	7
+NX_Q9ULE4	Protein FAM184B	1060	121044	5.87	0	NA	NA	NA	NA	Belongs to the FAM184 family.	NA	PE1	4
+NX_Q9ULE6	Paladin	856	96754	6.08	0	Cytosol	NA	NA	NA	Belongs to the paladin family.	NA	PE1	10
+NX_Q9ULF5	Zinc transporter ZIP10	831	94132	6.25	7	Membrane;Nucleoplasm;Cytosol;Cell membrane	NA	May act as a zinc-influx transporter.	NA	Belongs to the ZIP transporter (TC 2.A.5) family.	Zinc influx into cells by the SLC39 gene family	PE1	2
+NX_Q9ULG1	Chromatin-remodeling ATPase INO80	1556	176753	9.53	0	Cytoplasm;Chromosome;Nucleoplasm;Spindle;Nucleus	NA	ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820).	NA	Belongs to the SNF2/RAD54 helicase family.	DNA Damage Recognition in GG-NER;UCH proteinases	PE1	15
+NX_Q9ULG3	Uncharacterized protein KIAA1257	409	46740	8.11	0	NA	NA	NA	NA	NA	NA	PE1	3
+NX_Q9ULG6	Cell cycle progression protein 1	757	87340	5.67	1	Golgi apparatus;Endoplasmic reticulum;Cytoplasmic granule membrane	NA	Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.	NA	Belongs to the CCPG1 family.	NA	PE1	15
+NX_Q9ULH0	Kinase D-interacting substrate of 220 kDa	1771	196542	6.19	4	Membrane;Nucleoplasm;Late endosome	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.	Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF) (By similarity).;KIDINS220 is phosphorylated by NTRK1	NA	Neurotrophin signaling pathway;ARMS-mediated activation	PE1	2
+NX_Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	1129	125498	6.95	0	Cytoplasm;Cell membrane;Membrane;Centrosome;Cytosol	NA	Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.	Phosphorylated on tyrosine residues by SRC.	NA	Endocytosis;Fc gamma R-mediated phagocytosis;VxPx cargo-targeting to cilium	PE1	8
+NX_Q9ULH4	Leucine-rich repeat and fibronectin type-III domain-containing protein 2	789	84731	6.27	1	Membrane;Cytoplasmic vesicle;Synapse;Postsynaptic cell membrane	NA	Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity).	Glycosylated.	Belongs to the LRFN family.	Synaptic adhesion-like molecules	PE1	6
+NX_Q9ULH7	Myocardin-related transcription factor B	1088	118127	5.89	0	Nucleus speckle;Nucleus	NA	Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.	O-glycosylated.	NA	NA	PE1	16
+NX_Q9ULI0	ATPase family AAA domain-containing protein 2B	1458	164914	6.36	0	Nucleoplasm;Nucleus	NA	NA	NA	Belongs to the AAA ATPase family.	NA	PE1	2
+NX_Q9ULI1	NACHT and WD repeat domain-containing protein 2	1742	197466	5.85	0	NA	NA	NA	NA	NA	NA	PE1	4
+NX_Q9ULI2	Beta-citrylglutamate synthase B	386	42464	5.67	0	Nucleoplasm;Cytoplasm;Centriolar satellite	NA	Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate.	NA	Belongs to the RimK family.	Glutamate and glutamine metabolism	PE1	12
+NX_Q9ULI3	Protein HEG homolog 1	1381	147461	5.8	1	Cytoplasmic vesicle;Cell junction;Secreted;Cell membrane	NA	Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions.	NA	NA	NA	PE1	3
+NX_Q9ULI4	Kinesin-like protein KIF26A	1882	194590	9.12	0	Nucleoplasm;Cytosol;Cell membrane;Cytoskeleton	NA	Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity).	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.	MHC class II antigen presentation;Kinesins;COPI-dependent Golgi-to-ER retrograde traffic	PE1	14
+NX_Q9ULJ1	Protein BCAP	636	73728	6.09	0	Centrosome;Centriolar satellite;Cilium basal body;Centriole	NA	Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis.	NA	Belongs to the ODF2 family.	NA	PE1	1
+NX_Q9ULJ3	Zinc finger and BTB domain-containing protein 21	1066	118870	8.61	0	Nucleoplasm;Nucleus	NA	Acts as a transcription repressor.	NA	NA	NA	PE1	21
+NX_Q9ULJ6	Zinc finger MIZ domain-containing protein 1	1067	115483	7.09	0	Cytoplasm;Nucleoplasm;Nucleus speckle;Cytoplasmic vesicle	NA	Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity).	NA	NA	NA	PE1	10
+NX_Q9ULJ7	Ankyrin repeat domain-containing protein 50	1429	155859	6.13	0	Nucleoplasm;Endosome;Cytosol	NA	Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).	NA	NA	NA	PE1	4
+NX_Q9ULJ8	Neurabin-1	1098	123342	5.01	0	Synaptosome;Cytoskeleton;Cell membrane	NA	Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity).	NA	NA	NA	PE1	7
+NX_Q9ULK0	Glutamate receptor ionotropic, delta-1	1009	112131	6.23	3	Cell membrane;Postsynaptic cell membrane	NA	Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.	NA	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.	Neuroactive ligand-receptor interaction	PE1	10
+NX_Q9ULK2	Ataxin-7-like protein 1	861	91514	9.82	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	NA	NA	NA	NA	PE1	7
+NX_Q9ULK4	Mediator of RNA polymerase II transcription subunit 23	1368	156474	7.09	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	Mental retardation, autosomal recessive 18	Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.	NA	Belongs to the Mediator complex subunit 23 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	6
+NX_Q9ULK5	Vang-like protein 2	521	59714	9.27	4	Cell membrane	Neural tube defects	Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).	NA	Belongs to the Vang family.	Wnt signaling pathway;Asymmetric localization of PCP proteins;PCP/CE pathway	PE1	1
+NX_Q9ULK6	RING finger protein 150	438	48072	5.11	1	Membrane	NA	NA	NA	NA	NA	PE1	4
+NX_Q9ULL0	Acrosomal protein KIAA1210	1709	187021	8.72	0	Acrosome	NA	NA	NA	NA	NA	PE1	X
+NX_Q9ULL1	Pleckstrin homology domain-containing family G member 1	1385	155439	5.84	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	6
+NX_Q9ULL4	Plexin-B3	1909	206847	5.96	1	Cell membrane	NA	Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.	NA	Belongs to the plexin family.	Axon guidance;Other semaphorin interactions	PE1	X
+NX_Q9ULL5	Proline-rich protein 12	2036	211044	7.94	0	Cytosol;Postsynaptic density;Nucleus;Synaptosome	NA	NA	NA	NA	NA	PE1	19
+NX_Q9ULL8	Protein Shroom4	1493	164857	6.2	0	Cytoplasmic vesicle;Focal adhesion;Cytoskeleton	Mental retardation, X-linked, syndromic, Stocco dos Santos type	Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity).	NA	Belongs to the shroom family.	NA	PE1	X
+NX_Q9ULM0	Pleckstrin homology domain-containing family H member 1	1364	151232	8.17	0	Centrosome	NA	NA	NA	NA	NA	PE1	14
+NX_Q9ULM2	Zinc finger protein 490	529	61340	9.02	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9ULM3	YEATS domain-containing protein 2	1422	150782	9.1	0	Nucleoplasm;Nucleus	NA	Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431).	NA	NA	HATs acetylate histones	PE1	3
+NX_Q9ULM6	CCR4-NOT transcription complex subunit 6	557	63307	6.82	0	Cytoplasm;Cytosol;Nucleus	NA	Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.	NA	Belongs to the CCR4/nocturin family.	RNA degradation;Deadenylation of mRNA;Activation of anterior HOX genes in hindbrain development during early embryogenesis;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	5
+NX_Q9ULN7	Paraneoplastic antigen-like protein 8B	635	68615	5.35	0	NA	NA	NA	NA	Belongs to the PNMA family.	NA	PE1	19
+NX_Q9ULP0	Protein NDRG4	352	38459	5.79	0	Golgi apparatus;Nucleoplasm;Cytosol	NA	Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.	Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment.	Belongs to the NDRG family.	NA	PE1	16
+NX_Q9ULP9	TBC1 domain family member 24	559	62919	7.14	0	Cytoplasmic vesicle membrane;Cytoplasm;Cell junction;Cell membrane	Deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures syndrome;Deafness, autosomal dominant, 65;Familial infantile myoclonic epilepsy;Deafness, autosomal recessive, 86;Epileptic encephalopathy, early infantile, 16	May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515).	NA	NA	TBC/RABGAPs	PE1	16
+NX_Q9ULQ0	Striatin-interacting protein 2	834	95360	5.65	0	Cytoplasm;Cytosol	NA	Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.	NA	Belongs to the STRIP family.	NA	PE1	7
+NX_Q9ULQ1	Two pore calcium channel protein 1	816	94147	8.47	12	Lysosome membrane;Endosome membrane	NA	Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.	NA	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.	Stimuli-sensing channels	PE1	12
+NX_Q9ULR0	Pre-mRNA-splicing factor ISY1 homolog	285	32992	5.15	0	Nucleus speckle;Nucleus	NA	Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome.	NA	Belongs to the ISY1 family.	Spliceosome;mRNA Splicing - Major Pathway;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER	PE1	3
+NX_Q9ULR3	Protein phosphatase 1H	514	56448	6.14	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.	NA	Belongs to the PP2C family.	NA	PE1	12
+NX_Q9ULR5	Polyadenylate-binding protein-interacting protein 2B	123	14237	4.06	0	Cytosol	NA	Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.	Ubiquitinated in vitro.	Belongs to the PAIP2 family.	NA	PE1	2
+NX_Q9ULS5	Transmembrane and coiled-coil domain protein 3	477	53785	8.77	2	Endoplasmic reticulum;Cytoplasmic vesicle;Endoplasmic reticulum membrane	NA	NA	NA	Belongs to the TEX28 family.	NA	PE1	12
+NX_Q9ULS6	Potassium voltage-gated channel subfamily S member 2	477	54237	5.58	6	Cell membrane	NA	Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.	NA	Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily.	Voltage gated Potassium channels	PE1	8
+NX_Q9ULT0	Tetratricopeptide repeat protein 7A	858	96185	6.03	0	Cytoplasm;Cell membrane	Gastrointestinal defects and immunodeficiency syndrome	Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity).	NA	NA	NA	PE1	2
+NX_Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	936	100574	8.14	1	Golgi apparatus;Cell membrane	NA	E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).	NA	Belongs to the ZNRF3 family.	Protein modification; protein ubiquitination.;Regulation of FZD by ubiquitination	PE1	22
+NX_Q9ULT8	E3 ubiquitin-protein ligase HECTD1	2610	289384	5.21	0	Nucleoplasm;Nucleolus	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure.	NA	Belongs to the UPL family. K-HECT subfamily.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	14
+NX_Q9ULU4	Protein kinase C-binding protein 1	1186	131692	6.83	0	Golgi apparatus;Nucleoplasm;Cytoplasm;Nucleus	NA	May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.	NA	NA	NA	PE1	20
+NX_Q9ULU8	Calcium-dependent secretion activator 1	1353	152786	5.5	0	Cytoplasmic vesicle membrane;Cytoplasmic vesicle;Synapse	NA	Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).	NA	NA	NA	PE1	3
+NX_Q9ULV0	Unconventional myosin-Vb	1848	213672	6.77	0	Cytoplasm;Cell membrane	Diarrhea 2, with microvillus atrophy	May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Vasopressin regulates renal water homeostasis via Aquaporins	PE1	18
+NX_Q9ULV1	Frizzled-4	537	59881	7.05	7	Membrane;Nucleoplasm;Cell membrane	Vitreoretinopathy, exudative 1	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.	Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Asymmetric localization of PCP proteins;Class B/2 (Secretin family receptors);Ca2+ pathway;Regulation of FZD by ubiquitination;WNT5A-dependent internalization of FZD4;RNF mutants show enhanced WNT signaling and proliferation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	11
+NX_Q9ULV3	Cip1-interacting zinc finger protein	898	100045	5.77	0	Nucleoplasm;Nucleus	NA	May regulate the subcellular localization of CIP/WAF1.	NA	NA	NA	PE1	9
+NX_Q9ULV4	Coronin-1C	474	53249	6.65	0	Cytoplasm;Cell cortex;Cell membrane;Endosome membrane;Sarcomere;Lamellipodium;Synapse;Ruffle membrane;Sarcolemma;Cytoskeleton	NA	Involved in myogenic differentiation.;Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity).	NA	Belongs to the WD repeat coronin family.	NA	PE1	12
+NX_Q9ULV5	Heat shock factor protein 4	492	53011	5.29	0	Nucleus speckle;Nucleus	Cataract 5, multiple types	DNA-binding protein that specifically binds heat shock promoter elements (HSE).;Represses transcription while the isoform HSF4B activates transcription.	Is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by phosphorylation on Ser-298. HSFA is not sumoylated.;Phosphorylated mainly on serine residues. Phosphorylation on Ser-298 promotes sumoylation on Lys-293.;HSF4 is phosphorylated by MAPK3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the HSF family.	NA	PE1	16
+NX_Q9ULV8	E3 ubiquitin-protein ligase CBL-C	474	52456	7.83	0	Nucleoplasm	NA	Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR.;But not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.	But not isoform 2, is phosphorylated on tyrosines by EGFR.;Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC; suggesting proteasomal degradation.;Phosphorylated on multiple tyrosine residues by SRC.	NA	ErbB signaling pathway;Ubiquitin mediated proteolysis;Endocytosis;Jak-STAT signaling pathway;T cell receptor signaling pathway;Insulin signaling pathway;Bacterial invasion of epithelial cells;Pathways in cancer;Chronic myeloid leukemia	PE1	19
+NX_Q9ULW0	Targeting protein for Xklp2	747	85653	9.29	0	Nucleoplasm;Spindle pole;Spindle;Nucleus;Cytoskeleton	NA	Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).	TPX2 is phosphorylated by MAPK1;TPX2 is phosphorylated by AURKA (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the TPX2 family.	AURKA Activation by TPX2;Regulation of TP53 Activity through Phosphorylation	PE1	20
+NX_Q9ULW2	Frizzled-10	581	65336	8.83	7	Nucleoplasm;Cell membrane	NA	Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.	Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Class B/2 (Secretin family receptors)	PE1	12
+NX_Q9ULW3	Activator of basal transcription 1	272	31079	9.87	0	Cytoplasmic vesicle;Nucleus;Nucleolus	NA	Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).	NA	Belongs to the ESF2/ABP1 family.	NA	PE1	6
+NX_Q9ULW5	Ras-related protein Rab-26	256	27900	9.43	0	Cell membrane;Secretory vesicle membrane;Centrosome;Golgi apparatus membrane;Cytoplasmic vesicle	NA	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.	NA	Belongs to the small GTPase superfamily. Rab family.	RAB geranylgeranylation	PE1	16
+NX_Q9ULW6	Nucleosome assembly protein 1-like 2	460	52542	4.39	0	Cytosol;Nucleus;Cell membrane	NA	Acidic protein which may be involved in interactions with other proteins or DNA.	NA	Belongs to the nucleosome assembly protein (NAP) family.	NA	PE1	X
+NX_Q9ULW8	Protein-arginine deiminase type-3	664	74743	5.3	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle	Uncombable hair syndrome 1	Catalyzes the deimination of arginine residues of proteins.	NA	Belongs to the protein arginine deiminase family.	Chromatin modifying enzymes	PE1	1
+NX_Q9ULX3	RNA-binding protein NOB1	412	46675	6.72	0	Cytosol;Focal adhesion;Nucleus	NA	May play a role in mRNA degradation.	NA	Belongs to the NOB1 family.	Ribosome biogenesis in eukaryotes;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	16
+NX_Q9ULX5	RING finger protein 112	631	68298	8.88	2	Cytoplasm;Nucleus speckle;Perikaryon;Nuclear body;Membrane;Nucleoplasm;Endosome;Postsynaptic density;Neuron projection;Synaptic vesicle;Nucleus	NA	E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed:28684796). Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (By similarity).	Auto-ubiquitinated.	Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	Protein modification; protein ubiquitination.	PE1	17
+NX_Q9ULX6	A-kinase anchor protein 8-like	646	71640	4.94	0	Cytoplasm;Nucleus speckle;Nucleus matrix;PML body;Nucleus	NA	(Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.;(Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses.;(Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters.;Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903).	Phosphorylated on serine or threonine residues possibly by PKA; probably modulating the interaction with TMPO isoform Beta.	Belongs to the AKAP95 family.	NA	PE1	19
+NX_Q9ULX7	Carbonic anhydrase 14	337	37668	5.9	1	Membrane;Cell membrane	NA	Reversible hydration of carbon dioxide.	NA	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Reversible hydration of carbon dioxide	PE1	1
+NX_Q9ULX9	Transcription factor MafF	164	17760	9.85	0	Nucleoplasm;Mitochondrion;Nucleus	NA	Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:8932385, PubMed:16549056). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846).	NA	Belongs to the bZIP family. Maf subfamily.	Factors involved in megakaryocyte development and platelet production	PE1	22
+NX_Q9ULY5	C-type lectin domain family 4 member E	219	25073	5.12	1	Membrane;Cytosol	NA	A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109, PubMed:23602766). The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766, PubMed:24101491). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation. Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (By similarity).	NA	NA	Tuberculosis;Dectin-2 family	PE1	12
+NX_Q9ULZ0	TP53-target gene 3 protein	124	12828	8.18	0	Cytoplasm;Nucleus	NA	May play a significant role in p53/TP53-mediating signaling pathway.	NA	NA	NA	PE2	16
+NX_Q9ULZ1	Apelin	77	8569	11.83	0	Secreted;Extracellular space	NA	Endogenous ligand for the apelin receptor (APLNR) (PubMed:10525157). Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity).;(Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection (PubMed:11090199). Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR (PubMed:11090199). Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives (PubMed:11090199).	Several active peptides may be produced by proteolytic processing of the peptide precursor.	Belongs to the apelin family.	G alpha (i) signalling events;Peptide ligand-binding receptors	PE1	X
+NX_Q9ULZ2	Signal-transducing adaptor protein 1	295	34291	7.61	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.	Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT (By similarity).;STAP1 is phosphorylated by TEC (Phosphotyrosine:PTM-0255)	NA	NA	PE1	4
+NX_Q9ULZ3	Apoptosis-associated speck-like protein containing a CARD	195	21627	5.95	0	Cytoplasm;Mitochondrion;Nucleolus;Endoplasmic reticulum;Nucleoplasm;Golgi apparatus membrane;Cytosol;Nucleus	NA	May have a regulating effect on the function as inflammasome adapter.;Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation.;Seems to inhibit inflammasome-mediated maturation of interleukin-1 beta. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing. Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA (PubMed:28314590).	Phosphorylated.	NA	NOD-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Salmonella infection;Pertussis;Legionellosis;Influenza A;The NLRP3 inflammasome;CLEC7A/inflammasome pathway;The AIM2 inflammasome;Neutrophil degranulation	PE1	16
+NX_Q9ULZ9	Matrix metalloproteinase-17	603	66653	6.08	0	Extracellular matrix;Cell membrane	NA	Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.	The precursor is cleaved by a furin endopeptidase.	Belongs to the peptidase M10A family.	Activation of Matrix Metalloproteinases	PE1	12
+NX_Q9UM00	Calcium load-activated calcium channel	239	27079	10.27	2	Endoplasmic reticulum;Endoplasmic reticulum membrane;Golgi apparatus membrane	Glaucoma, primary open angle;Craniofacial dysmorphism, skeletal anomalies and mental retardation syndrome	Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239).	NA	Belongs to the TMCO1 family.	NA	PE1	1
+NX_Q9UM01	Y+L amino acid transporter 1	511	55991	5.29	12	Basolateral cell membrane	Lysinuric protein intolerance	Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.	Protein digestion and absorption;Amino acid transport across the plasma membrane;Basigin interactions;Defective SLC7A7 causes lysinuric protein intolerance (LPI)	PE1	14
+NX_Q9UM07	Protein-arginine deiminase type-4	663	74079	6.15	0	Cytoplasm;Cytoplasmic granule;Nucleus	Rheumatoid arthritis	Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.	Autocitrullination at Arg-372 and Arg-374 inactivates the enzyme.	Belongs to the protein arginine deiminase family.	Chromatin modifying enzymes	PE1	1
+NX_Q9UM11	Fizzy-related protein homolog	496	55179	9.41	0	Cytoplasm;Nucleoplasm;Nucleus membrane;Nucleus	NA	Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192).	Acetylated. Deacetylated by SIRT2 at Lys-69 and Lys-159; deacetylation enhances the interaction of FZR1 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).;Phosphorylated during mitosis, probably by maturation promoting factor (MPF), leading to its dissociation of the APC/C. Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK.;FZR1 is phosphorylated by PIM1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the WD repeat CDC20/Fizzy family.	Protein modification; protein ubiquitination.;Cell cycle;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of Emi1;Cyclin A:Cdk2-associated events at S phase entry	PE1	19
+NX_Q9UM13	Anaphase-promoting complex subunit 10	185	21252	9.17	0	Golgi apparatus;Nucleoplasm	NA	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	NA	Belongs to the APC10 family.	Protein modification; protein ubiquitination.;Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Separation of Sister Chromatids;CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination &amp; Proteasome degradation;Senescence-Associated Secretory Phenotype (SASP);Autodegradation of Cdh1 by Cdh1:APC/C;Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A	PE1	4
+NX_Q9UM19	Hippocalcin-like protein 4	191	22202	4.76	0	Cytoplasm;Nucleus	NA	May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.	NA	Belongs to the recoverin family.	NA	PE1	1
+NX_Q9UM21	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A	535	61544	6.94	1	Golgi apparatus;Secreted;Golgi apparatus membrane	NA	Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.	NA	Belongs to the glycosyltransferase 54 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;N-Glycan antennae elongation;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation	PE1	2
+NX_Q9UM22	Mammalian ependymin-related protein 1	224	25437	6.33	0	Secreted;Lysosome lumen	NA	Binds anionic lipids and gangliosides at acidic pH.	N-glycosylated; the glycan contains mannose-6-phosphate moieties.	Belongs to the ependymin family.	NA	PE1	7
+NX_Q9UM44	HERV-H LTR-associating protein 2	414	46850	5.77	1	Membrane	NA	Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.	NA	NA	NA	PE1	3
+NX_Q9UM47	Neurogenic locus notch homolog protein 3	2321	243631	5.18	1	Cell membrane;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Myofibromatosis, infantile 2;Lateral meningocele syndrome;Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, 1	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).	Hydroxylated by HIF1AN.;Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.;Phosphorylated.	Belongs to the NOTCH family.	Dorso-ventral axis formation;Notch signaling pathway;Pre-NOTCH Processing in the Endoplasmic Reticulum;Pre-NOTCH Transcription and Translation;Pre-NOTCH Processing in Golgi;Notch-HLH transcription pathway;Defective LFNG causes SCDO3;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH3 Intracellular Domain Regulates Transcription;Noncanonical activation of NOTCH3	PE1	19
+NX_Q9UM54	Unconventional myosin-VI	1294	149691	8.74	0	Clathrin-coated vesicle;Golgi apparatus;trans-Golgi network membrane;Clathrin-coated pit;Nucleoplasm;Filopodium;Clathrin-coated vesicle membrane;Ruffle membrane;Cytosol;Microvillus;Perinuclear region;Nucleus	Deafness, autosomal dominant, 22;Deafness, autosomal recessive, 37;Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy	Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370).	Phosphorylation in the motor domain, induced by EGF, results in translocation of MYO6 from the cell surface to membrane ruffles and affects F-actin dynamics. Phosphorylated in vitro by p21-activated kinase (PAK).	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Trafficking of AMPA receptors;Gap junction degradation	PE1	6
+NX_Q9UM63	Zinc finger protein PLAGL1	463	50819	8.85	0	Golgi apparatus;Nucleus;Cytoplasmic vesicle	Diabetes mellitus, transient neonatal, 1	Acts as a transcriptional activator (PubMed:9722527). Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	PE1	6
+NX_Q9UM73	ALK tyrosine kinase receptor	1620	176442	6.67	1	Cell membrane	Neuroblastoma 3	Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.	N-glycosylated.;Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation. Phosphorylation at Tyr-1507 is critical for SHC1 association.	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.	NA	PE1	2
+NX_Q9UM82	Spermatogenesis-associated protein 2	520	58427	9	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	NA	Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).	NA	Belongs to the SPATA2 family.	NA	PE1	20
+NX_Q9UMD9	Collagen alpha-1(XVII) chain	1497	150419	8.89	1	Golgi apparatus;Cell membrane;Hemidesmosome;Membrane;Basement membrane	Epithelial recurrent erosion dystrophy;Generalized atrophic benign epidermolysis bullosa	May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.;The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.	The intracellular/endo domain is disulfide-linked.;The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen. The shedding is mediated by membrane-bound metalloproteases. This cleavage is inhibited by phosphorylation at Ser-544.;Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.	NA	Protein digestion and absorption;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Collagen degradation;Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly;Collagen chain trimerization	PE1	10
+NX_Q9UMF0	Intercellular adhesion molecule 5	924	97116	5.71	1	Membrane	NA	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).	Glycosylation at Asn-54 is critical for functional folding.	Belongs to the immunoglobulin superfamily. ICAM family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions	PE1	19
+NX_Q9UMN6	Histone-lysine N-methyltransferase 2B	2715	293515	8.59	0	Nucleoplasm;Cytosol;Nucleus	Dystonia 28, childhood-onset	Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	Lysine degradation;PKMTs methylate histone lysines;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	19
+NX_Q9UMQ3	Homeobox protein BarH-like 2	279	31188	8.65	0	Nucleoplasm;Cytosol;Nucleus	NA	Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).	NA	Belongs to the BAR homeobox family.	NA	PE1	11
+NX_Q9UMQ6	Calpain-11	739	84423	5.39	0	Acrosome	NA	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.	NA	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	6
+NX_Q9UMR2	ATP-dependent RNA helicase DDX19B	479	53927	5.96	0	Cytoplasm;Nucleus envelope;Nucleus membrane;Nuclear pore complex	NA	ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.	NA	Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.	NA	PE1	16
+NX_Q9UMR3	T-box transcription factor TBX20	447	49232	7.29	0	Nucleus	Atrial septal defect 4	Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart.	NA	NA	NA	PE1	7
+NX_Q9UMR5	Lysosomal thioesterase PPT2	302	34225	5.87	0	Endoplasmic reticulum;Lysosome	NA	Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.	NA	Belongs to the palmitoyl-protein thioesterase family.	Fatty acid elongation;Metabolic pathways;Lysosome;Fatty acyl-CoA biosynthesis	PE1	6
+NX_Q9UMR7	C-type lectin domain family 4 member A	237	27512	6.32	1	Cell membrane	NA	C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner (PubMed:27015765). Involved in regulating immune reactivity (PubMed:18258799, PubMed:10438934). Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 (PubMed:18258799, PubMed:20530286). In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (PubMed:18258799). May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:10438934).;(Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases.	NA	NA	Dectin-2 family	PE1	12
+NX_Q9UMS0	NFU1 iron-sulfur cluster scaffold homolog, mitochondrial	254	28463	4.97	0	Nucleoplasm;Cytosol;Mitochondrion	Multiple mitochondrial dysfunctions syndrome 1	Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins.	NA	Belongs to the NifU family.	NA	PE1	2
+NX_Q9UMS4	Pre-mRNA-processing factor 19	504	55181	6.14	0	Cytoplasm;Nucleus speckle;Lipid droplet;Nucleoplasm;Spindle;Nucleus	NA	Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961, PubMed:30705154). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity).	NA	Belongs to the WD repeat PRP19 family.	Protein modification; protein ubiquitination.;Spliceosome;Ubiquitin mediated proteolysis;mRNA Splicing - Major Pathway;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER	PE1	11
+NX_Q9UMS5	Putative homeodomain transcription factor 1	762	87252	9.64	0	Nucleolus;Nucleus	NA	May play a role in transcription regulation.	NA	NA	NA	PE1	1
+NX_Q9UMS6	Synaptopodin-2	1093	117514	8.75	0	Cytoplasm;Focal adhesion;Cytoplasmic vesicle;Z line;Nucleus;Cytoskeleton	NA	Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers.;Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body.;Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles.;Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers.;Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro.;Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).	Phosphorylated by PKA, and by CaMK2 at multiple sites. Dephosphorylated by calcineurin; abrogating interaction with YWHAB and impairing nuclear import (By similarity). Phosphorylated by ILK.	Belongs to the synaptopodin family.	NA	PE1	4
+NX_Q9UMW8	Ubl carboxyl-terminal hydrolase 18	372	43011	8.05	0	Cytoplasm;Cytosol;Nucleus	Pseudo-TORCH syndrome 2	Involved in the regulation of inflammatory response to interferon type 1 (PubMed:27325888). Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.;Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins (PubMed:22170061).	NA	Belongs to the peptidase C19 family.	ISG15 antiviral mechanism;Regulation of IFNA signaling;Ub-specific processing proteases	PE1	22
+NX_Q9UMX0	Ubiquilin-1	589	62519	5.02	0	Cytoplasm;Cell membrane;Nucleoplasm;Endoplasmic reticulum;Autophagosome;Cytosol;Nucleus	NA	Play a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity).;Play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056).;Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982).	Degraded during both macroautophagy and during chaperone-mediated autophagy (CMA).;Ubiquitinated.;Phosphorylated.	NA	Protein processing in endoplasmic reticulum;Cargo recognition for clathrin-mediated endocytosis	PE1	9
+NX_Q9UMX1	Suppressor of fused homolog	484	53947	5.16	0	Nucleoplasm;Cytoplasm;Nucleus	Medulloblastoma;Basal cell nevus syndrome;Joubert syndrome 32	Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:27234298, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:28965847). Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24217340, PubMed:24311597). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24311597, PubMed:24217340). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) (PubMed:24311597, PubMed:28965847). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state (PubMed:24311597, PubMed:28965847). Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R (PubMed:24311597, PubMed:28965847). When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) (PubMed:24311597, PubMed:28965847). Required for normal embryonic development (By similarity). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).	Phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 prevents ubiquitination by the SCF(FBXL17) complex.;Polyubiquitinated at Lys-257 by the SCF(FBXL17) complex, leading to its subsequent degradation and allowing the release of GLI1 for proper hedgehog/smoothened signal transduction (PubMed:27234298). Ubiquitination is impaired by phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 (PubMed:27234298).	Belongs to the SUFU family.	Hedgehog signaling pathway;Pathways in cancer;Basal cell carcinoma;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'off' state	PE1	10
+NX_Q9UMX2	Ornithine decarboxylase antizyme 3	235	27413	6.38	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity).	NA	Belongs to the ODC antizyme family.	Regulation of ornithine decarboxylase (ODC)	PE1	1
+NX_Q9UMX3	Bcl-2-related ovarian killer protein	212	23280	9.33	1	Mitochondrion outer membrane;Cytoplasm;Nucleus outer membrane;Endoplasmic reticulum membrane;Mitochondrion;cis-Golgi network membrane;trans-Golgi network membrane;Membrane;Endoplasmic reticulum;Recycling endosome membrane;Early endosome membrane;Nucleus;Mitochondrion inner membrane;Mitochondrion membrane	NA	Pro-apoptotic molecule exerting its function through the mitochondrial pathway.;Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155).	Ubiquitinated by AMFR/gp78 E3 ubiquitin ligase complex; mediates degradation by ubiquitin-proteasome pathway in a VCP/p97-dependent manner; prevents from pro-apoptotic activity; promotes degradation of newly synthesized proteins that are not ITPR1 associated.	Belongs to the Bcl-2 family.	NA	PE1	2
+NX_Q9UMX5	Neudesin	172	18856	5.51	0	Nucleoplasm;Extracellular space	NA	Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190).	NA	Belongs to the cytochrome b5 family. MAPR subfamily.	NA	PE1	1
+NX_Q9UMX6	Guanylyl cyclase-activating protein 2	200	23420	4.75	0	Photoreceptor outer segment;Cell membrane	Retinitis pigmentosa 48	Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity).	The N-terminus is blocked.	NA	Olfactory transduction;Phototransduction;Inactivation, recovery and regulation of the phototransduction cascade	PE1	6
+NX_Q9UMX9	Membrane-associated transporter protein	530	58268	7.17	12	Melanosome membrane	Albinism, oculocutaneous, 4	Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity).	NA	Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.	Melanin biosynthesis	PE1	5
+NX_Q9UMY1	Nucleolar protein 7	257	29426	9.68	0	Nucleus;Nucleolus	NA	NA	NA	NA	NA	PE1	6
+NX_Q9UMY4	Sorting nexin-12	162	18885	8.58	0	Membrane	NA	May be involved in several stages of intracellular trafficking.	NA	Belongs to the sorting nexin family.	NA	PE1	X
+NX_Q9UMZ2	Synergin gamma	1314	140654	4.9	0	Cytoplasm;Cytosol;trans-Golgi network membrane	NA	May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins.	NA	NA	NA	PE1	17
+NX_Q9UMZ3	Phosphatidylinositol phosphatase PTPRQ	2332	260924	5.57	1	Membrane;Cytosol	Deafness, autosomal recessive, 84A;Deafness, autosomal dominant, 73	Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells.	NA	Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.	NA	PE1	12
+NX_Q9UN19	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide	280	32194	7.66	0	Membrane;Cytoplasm	NA	May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.	Phosphorylated on tyrosine residues.;DAPP1 is phosphorylated by BTK (Phosphotyrosine:PTM-0255)	NA	B cell receptor signaling pathway;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	PE1	4
+NX_Q9UN30	Sex comb on midleg-like protein 1	329	37447	6.42	0	Nucleoplasm;Nucleus	NA	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity).	NA	Belongs to the SCM family.	NA	PE1	X
+NX_Q9UN36	Protein NDRG2	371	40798	5.08	0	Golgi apparatus;Cytoplasm;Growth cone;Centriolar satellite;Nucleoplasm;Cytosol;Perinuclear region	NA	Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.	NA	Belongs to the NDRG family.	NA	PE1	14
+NX_Q9UN37	Vacuolar protein sorting-associated protein 4A	437	48898	7.64	0	Midbody;Late endosome membrane;Prevacuolar compartment membrane	NA	Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).	NA	Belongs to the AAA ATPase family.	Endocytosis;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT)	PE1	16
+NX_Q9UN42	Protein ATP1B4	357	41598	4.69	1	Nucleus inner membrane	NA	May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit.	NA	Belongs to the X(+)/potassium ATPases subunit beta family.	Cardiac muscle contraction;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Protein digestion and absorption;Bile secretion;Mineral absorption;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	PE1	X
+NX_Q9UN66	Protocadherin beta-8	801	87639	4.77	1	Cell membrane	NA	Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9UN67	Protocadherin beta-10	800	87621	4.75	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9UN70	Protocadherin gamma-C3	934	101077	5.07	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9UN71	Protocadherin gamma-B4	923	99927	4.8	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9UN72	Protocadherin alpha-7	937	100865	5.08	1	Cell membrane	NA	Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE2	5
+NX_Q9UN73	Protocadherin alpha-6	950	102716	4.93	1	Cytoplasmic vesicle;Secreted;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9UN74	Protocadherin alpha-4	947	102293	4.96	1	Nucleoplasm;Cytosol;Cell membrane	NA	Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9UN75	Protocadherin alpha-12	941	101652	5.13	1	Cytosol;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9UN76	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	642	72153	8.53	12	Membrane;Cytoplasmic vesicle	NA	Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily.	Amino acid transport across the plasma membrane;Na+/Cl- dependent neurotransmitter transporters;Variant SLC6A14 may confer susceptibility towards obesity	PE1	X
+NX_Q9UN79	Transcription factor SOX-13	622	69228	6.26	0	Nucleoplasm;Nucleus	NA	Binds to the sequence 5'-AACAAT-3'.	NA	NA	Deactivation of the beta-catenin transactivating complex	PE1	1
+NX_Q9UN81	LINE-1 retrotransposable element ORF1 protein	338	40056	9.54	0	Cytoplasmic ribonucleoprotein granule;Stress granule;Nucleolus	NA	Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.	Polyubiquitinated, probably by UBR2, which induces its degradation.	Belongs to the transposase 22 family.	NA	PE1	unknown
+NX_Q9UN86	Ras GTPase-activating protein-binding protein 2	482	54121	5.41	0	Cytoplasm;Cytosol;Stress granule	NA	Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling.	(Microbial infection) Cleaved by foot-and-mouth disease virus leader protease; this cleavage suppresses the formation of cytoplasmic stress granules.;Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.	NA	NA	PE1	4
+NX_Q9UN88	Gamma-aminobutyric acid receptor subunit theta	632	72022	5.55	3	Cell membrane;Postsynaptic cell membrane	NA	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.	NA	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily.	Neuroactive ligand-receptor interaction;GABAergic synapse;Signaling by ERBB4;GABA receptor activation	PE1	X
+NX_Q9UNA0	A disintegrin and metalloproteinase with thrombospondin motifs 5	930	101718	9.13	0	Nucleoplasm;Extracellular matrix	NA	Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.	C- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation can mediate the efficient secretion of ADAMTS family members. Can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).;The precursor is cleaved by furin and PCSK7 outside of the cell.;Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).	NA	Degradation of the extracellular matrix;O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	21
+NX_Q9UNA1	Rho GTPase-activating protein 26	814	92235	6.2	0	Cytosol;Focal adhesion;Cytoskeleton	Leukemia, juvenile myelomonocytic	GTPase-activating protein for RHOA and CDC42.	ARHGAP26 is phosphorylated by PKN3 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Rho GTPase cycle	PE1	5
+NX_Q9UNA3	Alpha-1,4-N-acetylglucosaminyltransferase	340	39497	6.42	1	Golgi apparatus membrane	NA	Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity).	NA	Belongs to the glycosyltransferase 32 family.	Protein modification; protein glycosylation.;O-linked glycosylation of mucins	PE1	3
+NX_Q9UNA4	DNA polymerase iota	740	83006	5.73	0	Cytoplasm;Cytosol;Nucleus speckle;Nucleus	NA	Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.	NA	Belongs to the DNA polymerase type-Y family.	Fanconi anemia pathway;Translesion synthesis by POLI;Termination of translesion DNA synthesis	PE1	18
+NX_Q9UND3	Nuclear pore complex-interacting protein family member A1	350	40133	9.48	0	Nucleus membrane;Nuclear pore complex	NA	NA	NA	Belongs to the NPIP family.	NA	PE2	16
+NX_Q9UNE0	Tumor necrosis factor receptor superfamily member EDAR	448	48582	5.08	1	Membrane	Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive;Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant	Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.	NA	NA	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	2
+NX_Q9UNE2	Rab effector Noc2	315	34464	9.23	0	Cytoplasm;Secretory vesicle membrane	NA	Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells.	NA	NA	NA	PE1	17
+NX_Q9UNE7	E3 ubiquitin-protein ligase CHIP	303	34856	5.61	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	Spinocerebellar ataxia, autosomal recessive, 16;Spinocerebellar ataxia 48	E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Likely mediates polyubiquitination and downregulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609).	Monoubiquitinated at Lys-2 following cell stress by UBE2W, promoting the interaction with ATXN3 (By similarity). Auto-ubiquitinated; mediated by UBE2D1 and UBE2D2.	NA	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downregulation of TGF-beta receptor signaling;Downregulation of ERBB2 signaling;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity	PE1	16
+NX_Q9UNF0	Protein kinase C and casein kinase substrate in neurons protein 2	486	55739	5.08	0	Cytoplasm;Nucleus speckle;Cell membrane;Early endosome;Cell projection;Cytoplasmic vesicle membrane;Caveola;Recycling endosome membrane;Ruffle membrane;Cytoplasmic vesicle;Cytosol;Cytoskeleton	NA	Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.	Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).	Belongs to the PACSIN family.	Clathrin-mediated endocytosis	PE1	22
+NX_Q9UNF1	Melanoma-associated antigen D2	606	64954	9.35	0	Nucleoplasm;Cytosol;Nucleolus	Bartter syndrome 5, antenatal, transient	Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule.	NA	NA	Platelet degranulation	PE1	X
+NX_Q9UNG2	Tumor necrosis factor ligand superfamily member 18	199	22724	7.62	1	Cell membrane	NA	Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).	NA	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors	PE1	1
+NX_Q9UNH5	Dual specificity protein phosphatase CDC14A	594	66574	9.21	0	Nucleoplasm;Spindle pole;Centrosome;Kinocilium;Stereocilium;Cytosol;Spindle;Nucleus	Deafness, autosomal recessive, 32, with or without immotile sperm	Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.	Cell cycle;MAPK6/MAPK4 signaling;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	PE1	1
+NX_Q9UNH6	Sorting nexin-7	387	45303	5.02	0	Cytoplasmic vesicle membrane;Cytosol;Nucleolus	NA	May be involved in several stages of intracellular trafficking.	NA	Belongs to the sorting nexin family.	NA	PE1	1
+NX_Q9UNH7	Sorting nexin-6	406	46649	5.81	0	Golgi apparatus;Cytoplasm;Early endosome;Endosome;Lysosome;Early endosome membrane;Cytoplasmic vesicle;Nucleus	NA	Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).	In vitro phosphorylated by PIM1; not affecting PIM1-dependent nuclear translocation (PubMed:11591366).	Belongs to the sorting nexin family.	NA	PE1	14
+NX_Q9UNI1	Chymotrypsin-like elastase family member 1	258	27798	8.59	0	Secreted	NA	Acts upon elastin.	NA	Belongs to the peptidase S1 family. Elastase subfamily.	NA	PE1	12
+NX_Q9UNI6	Dual specificity protein phosphatase 12	340	37687	6.41	0	Nucleoplasm;Cytosol;Nucleus	NA	Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	NA	PE1	1
+NX_Q9UNK0	Syntaxin-8	236	26907	4.91	1	Membrane;Golgi apparatus;Cytosol;Nucleus	NA	Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.	Ubiquitinated by HECTD3.	Belongs to the syntaxin family.	SNARE interactions in vesicular transport	PE1	17
+NX_Q9UNK4	Group IID secretory phospholipase A2	145	16546	8.6	0	Secreted	NA	PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.	NA	Belongs to the phospholipase A2 family.	Glycerophospholipid metabolism;Ether lipid metabolism;Arachidonic acid metabolism;Linoleic acid metabolism;alpha-Linolenic acid metabolism;Metabolic pathways;MAPK signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Fc epsilon RI signaling pathway;Glutamatergic synapse;Long-term depression;GnRH signaling pathway;Pancreatic secretion;Fat digestion and absorption;Toxoplasmosis;Synthesis of PA;Acyl chain remodelling of PG;Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI	PE1	1
+NX_Q9UNK9	Protein angel homolog 1	670	75276	4.72	0	Nucleoplasm	NA	NA	NA	Belongs to the CCR4/nocturin family.	NA	PE1	14
+NX_Q9UNL2	Translocon-associated protein subunit gamma	185	21080	9.61	4	Endoplasmic reticulum membrane	NA	TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.	NA	Belongs to the TRAP-gamma family.	Protein processing in endoplasmic reticulum;SRP-dependent cotranslational protein targeting to membrane	PE1	3
+NX_Q9UNL4	Inhibitor of growth protein 4	249	28530	7.53	0	Nucleoplasm;Nucleus	NA	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).	Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases susceptibility to degradation.	Belongs to the ING family.	HATs acetylate histones	PE1	12
+NX_Q9UNM6	26S proteasome non-ATPase regulatory subunit 13	376	42945	5.53	0	Cytosol;Nucleus speckle	NA	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.	NA	Belongs to the proteasome subunit S11 family.	Proteasome;Activation of NF-kappaB in B cells;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;MAPK6/MAPK4 signaling;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Antigen processing: Ubiquitination &amp; Proteasome degradation;Downstream TCR signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Autodegradation of Cdh1 by Cdh1:APC/C;SCF(Skp2)-mediated degradation of p27/p21;ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis;G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint;UCH proteinases;Ub-specific processing proteases;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Neutrophil degranulation;Neddylation;Regulation of RUNX3 expression and activity;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Ubiquitin-dependent degradation of Cyclin D	PE1	11
+NX_Q9UNN4	TFIIA-alpha and beta-like factor	478	52444	4.58	0	Nucleus	NA	May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.	NA	Belongs to the TFIIA subunit 1 family.	Basal transcription factors	PE1	2
+NX_Q9UNN5	FAS-associated factor 1	650	73954	4.81	0	Nucleoplasm;Nucleus	NA	Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity).	NA	NA	NA	PE1	1
+NX_Q9UNN8	Endothelial protein C receptor	238	26671	6.7	1	Membrane;Cytoplasm;Cell membrane	NA	Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.	N-glycosylated.;A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.	NA	Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall	PE1	20
+NX_Q9UNP4	Lactosylceramide alpha-2,3-sialyltransferase	418	47990	9.13	1	Cytoplasmic vesicle;Golgi apparatus membrane	Salt and pepper developmental regression syndrome	Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).	N-glycosylated.	Belongs to the glycosyltransferase 29 family.	Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways;Sialic acid metabolism	PE1	2
+NX_Q9UNP9	Peptidyl-prolyl cis-trans isomerase E	301	33431	5.41	0	Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20460131). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:8977107, PubMed:18258190, PubMed:20460131). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20541251). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20677832, PubMed:20541251, PubMed:20460131).	NA	Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.	Spliceosome;mRNA Splicing - Major Pathway;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Neutrophil degranulation	PE1	1
+NX_Q9UNQ0	Broad substrate specificity ATP-binding cassette transporter ABCG2	655	72314	8.91	6	Mitochondrion membrane;Nucleoplasm;Apical cell membrane;Cell membrane	NA	Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity).	N-glycosylated (PubMed:15807535, PubMed:23189181). Glycosylation-deficient ABCG2 is normally expressed and functional.;Phosphorylated. Phosphorylation at Thr-362 by PIM1 is induced by drugs like mitoxantrone and is associated with cells increased drug resistance. It regulates the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.	ABC transporters;Bile secretion;Abacavir transmembrane transport;Iron uptake and transport	PE1	4
+NX_Q9UNQ2	Probable dimethyladenosine transferase	313	35236	10.01	0	Nucleoplasm;Cytosol;Nucleolus	NA	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604).	NA	Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	rRNA modification in the nucleus and cytosol	PE1	5
+NX_Q9UNS1	Protein timeless homolog	1208	138658	5.28	0	Nucleoplasm;Nucleus;Chromosome	NA	Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:9856465, PubMed:17141802, PubMed:17296725, PubMed:23418588, PubMed:26344098). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity).	TIMELESS is phosphorylated by YES1	Belongs to the timeless family.	Processing of DNA double-strand break ends	PE1	12
+NX_Q9UNS2	COP9 signalosome complex subunit 3	423	47873	6.19	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.	NA	Belongs to the CSN3 family.	Formation of TC-NER Pre-Incision Complex;DNA Damage Recognition in GG-NER;Cargo recognition for clathrin-mediated endocytosis;Neddylation	PE1	17
+NX_Q9UNT1	Rab-like protein 2B	228	26101	4.75	0	Cytoplasm;Cilium basal body;Centriole	NA	Small GTPase required for ciliation. Activated in a guanine nucleotide exchange factor (GEF)-independent manner via its intrinsic GDP for GTP nucleotide exchange ability (PubMed:28625565). Involved in ciliary assembly by binding the intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28625565, PubMed:28428259).	NA	Belongs to the small GTPase superfamily. Rab family.	NA	PE1	22
+NX_Q9UNU6	7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	501	58068	8.78	1	Microsome membrane;Endoplasmic reticulum membrane	NA	Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.	NA	Belongs to the cytochrome P450 family.	Primary bile acid biosynthesis;Metabolic pathways;PPAR signaling pathway;Synthesis of Prostaglandins (PG) and Thromboxanes (TX);Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol;Nicotinamide salvaging;Eicosanoids;Sterols are 12-hydroxylated by CYP8B1	PE1	3
+NX_Q9UNW1	Multiple inositol polyphosphate phosphatase 1	487	55051	7.93	0	Endoplasmic reticulum lumen	Thyroid cancer, non-medullary, 2	Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity).	NA	Belongs to the histidine acid phosphatase family. MINPP1 subfamily.	Inositol phosphate metabolism;Synthesis of IPs in the ER lumen	PE1	10
+NX_Q9UNW8	Probable G-protein coupled receptor 132	380	42499	8.95	7	Cell membrane	NA	May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (q) signalling events;Class A/1 (Rhodopsin-like receptors)	PE1	14
+NX_Q9UNW9	RNA-binding protein Nova-2	492	49009	8.24	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.	NA	NA	NA	PE1	19
+NX_Q9UNX3	60S ribosomal protein L26-like 1	145	17256	10.55	0	NA	NA	NA	NA	Belongs to the universal ribosomal protein uL24 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	5
+NX_Q9UNX4	WD repeat-containing protein 3	943	106099	6.2	0	Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the WD repeat WDR3/UTP12 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	1
+NX_Q9UNX9	ATP-sensitive inward rectifier potassium channel 14	436	47846	5.25	2	Membrane;Nucleolus	NA	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).	NA	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily.	Cholinergic synapse;Classical Kir channels;Phase 4 - resting membrane potential	PE1	19
+NX_Q9UNY4	Transcription termination factor 2	1162	129588	8.63	0	Cytoplasm;Cytosol;Nucleus	NA	DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.	NA	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	1
+NX_Q9UNY5	Zinc finger protein 232	417	47688	6.28	0	Nucleoplasm;Cytosol;Nucleus;Cytoplasmic vesicle	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	17
+NX_Q9UNZ2	NSFL1 cofactor p47	370	40573	4.99	0	Cell membrane;Chromosome;Nucleoplasm;Centrosome;Cytosol;Golgi stack;Nucleus	NA	Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807).	Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis (By similarity).	Belongs to the NSFL1C family.	Protein processing in endoplasmic reticulum	PE1	20
+NX_Q9UNZ5	Leydig cell tumor 10 kDa protein homolog	99	10577	11.55	0	Nucleoplasm;Nucleus;Nucleolus	NA	May have a potential role in hypercalcemia of malignancy.	NA	Belongs to the UPF0390 family.	NA	PE1	19
+NX_Q9UP38	Frizzled-1	647	71158	8.33	7	Cell membrane	NA	Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.	Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;Asymmetric localization of PCP proteins;Class B/2 (Secretin family receptors);TCF dependent signaling in response to WNT;PCP/CE pathway;Disassembly of the destruction complex and recruitment of AXIN to the membrane	PE1	7
+NX_Q9UP52	Transferrin receptor protein 2	801	88755	5.72	1	Cytoplasm;Cell membrane	Hemochromatosis 3	Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.	NA	Belongs to the peptidase M28 family. M28B subfamily.	Transferrin endocytosis and recycling	PE1	7
+NX_Q9UP65	Cytosolic phospholipase A2 gamma	541	60939	6.46	0	Membrane;Cytosol	NA	Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.	NA	NA	Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC;Hydrolysis of LPE	PE1	19
+NX_Q9UP79	A disintegrin and metalloproteinase with thrombospondin motifs 8	889	96460	5.78	0	Extracellular matrix	NA	Has anti-angiogenic properties.	Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).;The precursor is cleaved by a furin endopeptidase.	NA	Degradation of the extracellular matrix;O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	11
+NX_Q9UP83	Conserved oligomeric Golgi complex subunit 5	839	92743	6.15	0	Nucleoplasm;Golgi apparatus;Cytosol;Golgi apparatus membrane	Congenital disorder of glycosylation 2I	Required for normal Golgi function.	NA	Belongs to the COG5 family.	Intra-Golgi traffic;COPI-mediated anterograde transport;Retrograde transport at the Trans-Golgi-Network	PE1	7
+NX_Q9UP95	Solute carrier family 12 member 4	1085	120650	6.02	12	Membrane;Endosome	NA	Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity).;Has no transport activity.	N-glycosylated.	Belongs to the SLC12A transporter family.	Cation-coupled Chloride cotransporters	PE1	16
+NX_Q9UPA5	Protein bassoon	3926	416469	7.28	0	Cytoplasm;Presynaptic active zone;Synaptic vesicle membrane;Cytoskeleton	NA	Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity).	Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization (By similarity).	NA	NA	PE1	3
+NX_Q9UPC5	Probable G-protein coupled receptor 34	381	43860	9.89	7	Nucleoplasm;Cytosol;Cell membrane	NA	Orphan receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	X
+NX_Q9UPE1	SRSF protein kinase 3	567	62014	6.83	0	NA	NA	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).	NA	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.	NA	PE1	X
+NX_Q9UPG8	Zinc finger protein PLAGL2	496	54584	8.95	0	Nucleoplasm;Cytosol;Nucleus	NA	Shows weak transcriptional activatory activity.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	20
+NX_Q9UPI3	Feline leukemia virus subgroup C receptor-related protein 2	526	57241	5.78	12	Cell membrane	Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome	Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.	NA	Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.	NA	PE1	14
+NX_Q9UPM6	LIM/homeobox protein Lhx6	363	40045	8.77	0	Nucleolus;Nucleus;Cell membrane	NA	Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity).	NA	NA	NA	PE1	9
+NX_Q9UPM8	AP-4 complex subunit epsilon-1	1137	127287	5.66	0	trans-Golgi network membrane	Stuttering, familial persistent 1;Spastic paraplegia 51, autosomal recessive	Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).	NA	Belongs to the adaptor complexes large subunit family.	Lysosome;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis	PE1	15
+NX_Q9UPM9	B9 domain-containing protein 1	204	22775	6.73	0	Cilium axoneme;Cilium basal body	Meckel syndrome 9;Joubert syndrome 27	Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).	NA	Belongs to the B9D family.	Anchoring of the basal body to the plasma membrane	PE1	17
+NX_Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5	7388	838308	5.28	0	Cytoplasm;Golgi apparatus;Cell membrane;Ruffle membrane;Cytoskeleton	Lissencephaly 9 with complex brainstem malformation	F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity).	Phosphorylated on serine residues in the C-terminal tail by GSK3B. Phosphorylation inhibits microtubule-binding and this plays a critical role in bulge stem cell migration and skin wound repair. Wnt-signaling can repress phosphorylation (By similarity).;MACF1 is phosphorylated by GSK3B (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the plakin or cytolinker family.	NA	PE1	1
+NX_Q9UPN4	Centrosomal protein of 131 kDa	1083	122149	8.84	0	Acrosome;Centriolar satellite;Cilium basal body;Centrosome;Cytoskeleton	NA	Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).	MAPKAPK2-dependent phosphorylation at Ser-47 and Ser-78 occurs in response to cellular stress such as exposure to ultraviolet irradiation and promotes binding to 14-3-3 proteins which leads to cytoplasmic sequestration of CEP131 and blocks formation of new centriolar satellites.;Ubiquitinated. Undergoes monoubiquitination catalyzed by the E3 ubiquitin-protein ligase MIB1 in proliferating cells, preventing cilia formation. Monoubiquitination by MIB1 is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, resulting in cilia formation initiation.	Belongs to the CEP131 family.	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	17
+NX_Q9UPN6	SR-related and CTD-associated factor 8	1271	140519	8.41	0	Nucleoplasm;Nucleus matrix;Nucleus	NA	Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839).	NA	NA	NA	PE1	6
+NX_Q9UPN7	Serine/threonine-protein phosphatase 6 regulatory subunit 1	881	96724	4.45	0	Cytoplasm;Cytosol	NA	Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.	NA	Belongs to the SAPS family.	COPII-mediated vesicle transport	PE1	19
+NX_Q9UPN9	E3 ubiquitin-protein ligase TRIM33	1127	122533	6.23	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).	Sumoylated with SUMO1.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Downregulation of SMAD2/3:SMAD4 transcriptional activity	PE1	1
+NX_Q9UPP1	Histone lysine demethylase PHF8	1060	117864	8.92	0	Nucleoplasm;Nucleolus;Nucleus	Mental retardation, X-linked, syndromic, Siderius type	Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3.	Phosphorylation at Ser-69 and Ser-120 are required for dissociation from chromatin and accumulation of H4K20Me1 levels during prophase.	Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.	Condensation of Prophase Chromosomes;HDMs demethylate histones	PE1	X
+NX_Q9UPP2	IQ motif and SEC7 domain-containing protein 3	1182	127621	6.08	0	Nucleoplasm;Cytosol;Cytoplasm;Postsynaptic density	NA	Acts as a guanine nucleotide exchange factor (GEF) for ARF1.	NA	Belongs to the BRAG family.	Endocytosis	PE1	12
+NX_Q9UPP5	AP2-interacting clathrin-endocytosis protein	1279	140918	5.93	0	Clathrin-coated vesicle;Presynapse;Axon	NA	Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.	NA	NA	NA	PE1	1
+NX_Q9UPQ0	LIM and calponin homology domains-containing protein 1	1083	121867	6.1	0	Stress fiber;Cytoskeleton;Cell membrane	NA	Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.	NA	Belongs to the LIMCH1 family.	NA	PE1	4
+NX_Q9UPQ3	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1	857	94470	8.18	0	Cytoplasm	NA	GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.	Phosphorylated on tyrosines.	Belongs to the centaurin gamma-like family.	Endocytosis	PE1	2
+NX_Q9UPQ4	Tripartite motif-containing protein 35	493	56540	6.71	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Involved in the cell death mechanism (By similarity).	NA	Belongs to the TRIM/RBCC family.	Interferon gamma signaling	PE1	8
+NX_Q9UPQ7	E3 ubiquitin-protein ligase PDZRN3	1066	119596	5.68	0	Cytoplasm;Synapse	NA	E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.	Auto-ubiquitinated.	NA	Protein modification; protein ubiquitination.	PE1	3
+NX_Q9UPQ8	Dolichol kinase	538	59268	8.87	15	Golgi apparatus;Endoplasmic reticulum membrane;Nucleolus;Nucleoplasm;Cytosol	Congenital disorder of glycosylation 1M	Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.	NA	Belongs to the polyprenol kinase family.	N-Glycan biosynthesis;Metabolic pathways;Synthesis of Dolichyl-phosphate;Defective DOLK causes DOLK-CDG (CDG-1m)	PE1	9
+NX_Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	1833	194002	6.31	0	P-body	NA	Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.	NA	Belongs to the GW182 family.	MAPK6/MAPK4 signaling;Oxidative Stress Induced Senescence;Pre-NOTCH Transcription and Translation;TP53 Regulates Metabolic Genes;Ca2+ pathway;Post-transcriptional silencing by small RNAs;Oncogene Induced Senescence;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of RUNX1 Expression and Activity;Regulation of PTEN mRNA translation;Competing endogenous RNAs (ceRNAs) regulate PTEN translation;Estrogen-dependent gene expression;Transcriptional Regulation by MECP2;Regulation of MECP2 expression and activity	PE1	22
+NX_Q9UPR0	Inactive phospholipase C-like protein 2	1127	125866	6.47	0	Cytoplasm	NA	May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.	NA	NA	NA	PE1	3
+NX_Q9UPR3	Protein SMG5	1016	113928	5.63	0	Cytoplasm;Cytosol;Nucleus	NA	Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.	NA	NA	mRNA surveillance pathway;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PE1	1
+NX_Q9UPR5	Sodium/calcium exchanger 2	921	100368	5.02	11	Dendritic spine;Cell membrane;Basolateral cell membrane;Perikaryon;Dendrite	NA	Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.	NA	Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.	Calcium signaling pathway;Protein digestion and absorption;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis	PE1	19
+NX_Q9UPR6	Zinc finger RNA-binding protein 2	939	101330	8.76	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q9UPS6	Histone-lysine N-methyltransferase SETD1B	1966	212803	4.86	0	Nucleoplasm;Nucleus speckle;Chromosome	NA	Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.	NA	Belongs to the class V-like SAM-binding methyltransferase superfamily.	Lysine degradation;PKMTs methylate histone lysines;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	PE1	12
+NX_Q9UPS8	Ankyrin repeat domain-containing protein 26	1710	196411	5.54	0	Golgi apparatus;Cytoplasmic vesicle	Thrombocytopenia 2	Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior.	NA	NA	NA	PE1	10
+NX_Q9UPT5	Exocyst complex component 7	735	83382	6.33	0	Cytoplasmic vesicle;Cytosol;Cell membrane;Midbody ring	NA	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).	NA	Belongs to the EXO70 family.	Insulin signaling pathway;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium	PE1	17
+NX_Q9UPT6	C-Jun-amino-terminal kinase-interacting protein 3	1336	147457	5.26	0	Golgi apparatus;Cytoplasm;Growth cone;Dendrite;Cytoplasmic vesicle;Axon;Perinuclear region	NA	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604).	Phosphorylation by ROCK1 is crucial for the recruitment of JNK.	Belongs to the JIP scaffold family.	MAPK signaling pathway	PE1	16
+NX_Q9UPT8	Zinc finger CCCH domain-containing protein 4	1303	140257	5.87	0	Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	NA	PE1	19
+NX_Q9UPT9	Ubiquitin carboxyl-terminal hydrolase 22	525	59961	8.37	0	Nucleus speckle;Nucleus	NA	Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.	NA	Belongs to the peptidase C19 family. UBP8 subfamily.	HATs acetylate histones;Ub-specific processing proteases	PE1	17
+NX_Q9UPU3	VPS10 domain-containing receptor SorCS3	1222	135755	6.14	1	Membrane	NA	NA	NA	Belongs to the VPS10-related sortilin family. SORCS subfamily.	NA	PE1	10
+NX_Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	2620	294365	5.79	0	Nucleoplasm;Cytosol	NA	Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron.	NA	Belongs to the peptidase C19 family.	Ub-specific processing proteases	PE1	1
+NX_Q9UPU7	TBC1 domain family member 2B	963	109880	5.85	0	Cytosol	NA	May act as a GTPase-activating protein.	NA	NA	NA	PE1	15
+NX_Q9UPU9	Protein Smaug homolog 1	718	79415	8.61	0	Cytoplasm;Synaptosome;Cell junction;Cytosol;Dendrite	NA	Acts as a translational repressor of SRE-containing messengers.	NA	Belongs to the SMAUG family.	NA	PE1	14
+NX_Q9UPV0	Centrosomal protein of 164 kDa	1460	164314	5.27	0	Nucleoplasm;Centrosome;Nucleus;Centriole	Nephronophthisis 15	Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.	Phosphorylation at Ser-186 is induced upon DNA-damage caused by treatment with IR irradiation, UV irradiation, hydroxyurea or amphidicolin. Also MDC1-mediated chromatin remodeling is critical for DNA damage-induced phosphorylation.	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	11
+NX_Q9UPV7	PHD finger protein 24	400	45192	5.48	0	NA	NA	NA	NA	NA	NA	PE1	9
+NX_Q9UPV9	Trafficking kinesin-binding protein 1	953	106040	5.59	0	Cytoplasm;Cell cortex;Mitochondrion;Early endosome;Endoplasmic reticulum;Endosome;Nucleoplasm;Mitochondrion membrane;Nucleus	Epileptic encephalopathy, early infantile, 68	Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity).	O-glycosylated (PubMed:24995978, PubMed:12435728). Glycosylated by OGT; glycosylation in response to increased extracellular glucose levels is required for and leads to regulation of mitochondrial motility by OGT (PubMed:24995978).	Belongs to the milton family.	Signaling by BRAF and RAF fusions	PE1	3
+NX_Q9UPW0	Forkhead box protein J3	622	68960	6.59	0	Nucleoplasm;Nucleus speckle;Nucleus;Cytoplasmic vesicle	NA	Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.	NA	NA	NA	PE1	1
+NX_Q9UPW5	Cytosolic carboxypeptidase 1	1226	138448	5.78	0	Cytoplasm;Mitochondrion;Nucleolus;Cytoplasmic vesicle;Cytosol;Nucleus	Neurodegeneration, childhood-onset, with cerebellar atrophy	Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins (PubMed:30420557). Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.	NA	Belongs to the peptidase M14 family.	Carboxyterminal post-translational modifications of tubulin	PE1	9
+NX_Q9UPW6	DNA-binding protein SATB2	733	82555	6.44	0	Nucleoplasm;Nucleus matrix	Cleft palate isolated	Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.	Sumoylated by PIAS1. Sumoylation promotes nuclear localization, but represses transcription factor activity.	Belongs to the CUT homeobox family.	SUMOylation of chromatin organization proteins;RUNX2 regulates osteoblast differentiation	PE1	2
+NX_Q9UPW8	Protein unc-13 homolog A	1703	193014	5.21	0	Cytoplasm;Presynaptic active zone;Presynaptic cell membrane;Cell membrane	NA	Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).	NA	Belongs to the unc-13 family.	Synaptic vesicle cycle	PE1	19
+NX_Q9UPX0	Protein turtle homolog B	1349	147089	6.22	1	Cytosol;Postsynaptic density;Postsynaptic cell membrane	NA	Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion.	N-glycosylated and sialylated. Not significantly O-glycosylated.	Belongs to the immunoglobulin superfamily. Turtle family.	NA	PE1	11
+NX_Q9UPX6	Major intrinsically disordered Notch2-binding receptor 1	916	102993	7.04	1	Golgi apparatus;Cell membrane	NA	Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR (PubMed:30080879). Negatively regulates angiogenesis (PubMed:29329397). Negatively regulates cell growth (PubMed:29329397, PubMed:30080879). Negatively regulates neurite outgrowth in hippocampal neurons (By similarity).	NA	Belongs to the MINAR family.	NA	PE1	15
+NX_Q9UPX8	SH3 and multiple ankyrin repeat domains protein 2	1470	158822	6.48	0	Cytoplasm;Dendritic spine;Nucleus speckle;Growth cone;Nucleoplasm;Postsynaptic density;Synapse;Cytoplasmic vesicle;Apical cell membrane	Autism 17	Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.	NA	Belongs to the SHANK family.	Glutamatergic synapse;Neurexins and neuroligins	PE1	11
+NX_Q9UPY3	Endoribonuclease Dicer	1922	218682	5.47	0	Cytoplasm;Cytosol	Global developmental delay, lung cysts, overgrowth, and Wilms tumor;Pleuropulmonary blastoma;Rhabdomyosarcoma, embryonal, 2;Goiter multinodular 1, with or without Sertoli-Leydig cell tumors	Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.	NA	Belongs to the helicase family. Dicer subfamily.	MicroRNA (miRNA) biogenesis;Small interfering RNA (siRNA) biogenesis	PE1	14
+NX_Q9UPY5	Cystine/glutamate transporter	501	55423	9.29	12	Membrane;Cytoplasmic vesicle	NA	Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.	NA	Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.	Amino acid transport across the plasma membrane;Basigin interactions	PE1	4
+NX_Q9UPY6	Wiskott-Aldrich syndrome protein family member 3	502	55293	6	0	Cytoskeleton	NA	Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.	Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.	Belongs to the SCAR/WAVE family.	Adherens junction;Fc gamma R-mediated phagocytosis;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;VEGFA-VEGFR2 Pathway	PE1	13
+NX_Q9UPY8	Microtubule-associated protein RP/EB family member 3	281	31982	5.33	0	Cytosol;Cytoskeleton	NA	Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity).	NA	Belongs to the MAPRE family.	NA	PE1	2
+NX_Q9UPZ3	Hermansky-Pudlak syndrome 5 protein	1129	127449	5.35	0	Cytosol	Hermansky-Pudlak syndrome 5	May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins.	NA	Belongs to the HPS5 family.	NA	PE1	11
+NX_Q9UPZ6	Thrombospondin type-1 domain-containing protein 7A	1657	185363	7.74	1	Secreted;Cell projection;Cell membrane	NA	Thrombospondin type-1 domain-containing protein 7A, soluble form: The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.;Thrombospondin type-1 domain-containing protein 7A: Plays a role in actin cytoskeleton rearrangement.	Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form.;Extensively N-glycosylated.	NA	O-glycosylation of TSR domain-containing proteins;Defective B3GALTL causes Peters-plus syndrome (PpS)	PE1	7
+NX_Q9UPZ9	Serine/threonine-protein kinase ICK	632	71427	9.79	0	Cytoplasm;Cilium;Nucleolus;Cilium basal body;Cytosol;Nucleus	Endocrine-cerebroosteodysplasia;Juvenile myoclonic epilepsy 10	Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity).	Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-157 increases kinase activity.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	6
+NX_Q9UQ03	Coronin-2B	480	54953	8.53	0	Focal adhesion;Cell membrane;Cytoskeleton	NA	May play a role in the reorganization of neuronal actin structure.	NA	Belongs to the WD repeat coronin family.	NA	PE1	15
+NX_Q9UQ05	Potassium voltage-gated channel subfamily H member 4	1017	111693	8.87	6	Membrane	NA	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.	NA	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.3/KCNH4 sub-subfamily.	Voltage gated Potassium channels	PE2	17
+NX_Q9UQ07	MAPK/MAK/MRK overlapping kinase	419	48014	9.64	0	Endoplasmic reticulum;Cytoplasm;Cilium;Nucleus	NA	Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.	Autophosphorylated.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	NA	PE1	14
+NX_Q9UQ10	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	334	36382	6.76	0	Nucleoplasm;Cytoskeleton	NA	NA	NA	Belongs to the Gfo/Idh/MocA family.	Pentose and glucuronate interconversions;Metabolism of xenobiotics by cytochrome P450	PE1	19
+NX_Q9UQ13	Leucine-rich repeat protein SHOC-2	582	64888	8.65	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	Noonan syndrome-like disorder with loose anagen hair 1	Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.	NA	Belongs to the SHOC2 family.	NA	PE1	10
+NX_Q9UQ16	Dynamin-3	869	97746	8.51	0	Golgi apparatus;Cytoplasm;Cytoskeleton	NA	Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).	NA	Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Endocytosis;Fc gamma R-mediated phagocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Bacterial invasion of epithelial cells;MHC class II antigen presentation;Toll Like Receptor 4 (TLR4) Cascade;Retrograde neurotrophin signalling;Recycling pathway of L1;Clathrin-mediated endocytosis	PE1	1
+NX_Q9UQ26	Regulating synaptic membrane exocytosis protein 2	1411	160403	9.17	0	Cytosol;Synapse;Presynaptic cell membrane;Cell membrane	NA	Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003).	NA	NA	NA	PE1	8
+NX_Q9UQ35	Serine/arginine repetitive matrix protein 2	2752	299615	12.05	0	Cytoplasm;Nucleus speckle;Nucleus	NA	Required for pre-mRNA splicing as component of the spliceosome.	NA	Belongs to the CWC21 family.	mRNA Splicing - Major Pathway	PE1	16
+NX_Q9UQ49	Sialidase-3	428	48252	6.78	0	Cytoplasmic vesicle;Nucleoplasm;Cell membrane	NA	Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.	NA	Belongs to the glycosyl hydrolase 33 family.	Sialic acid metabolism;Glycosphingolipid metabolism	PE1	11
+NX_Q9UQ52	Contactin-6	1028	113956	5.73	0	Cell membrane	NA	Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity).	NA	Belongs to the immunoglobulin superfamily. Contactin family.	CHL1 interactions	PE1	3
+NX_Q9UQ53	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B	548	63198	7.72	1	Golgi apparatus membrane	NA	Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis.	NA	Belongs to the glycosyltransferase 54 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;N-Glycan antennae elongation	PE1	5
+NX_Q9UQ72	Pregnancy-specific beta-1-glycoprotein 11	335	37146	6.65	0	Secreted	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall	PE1	19
+NX_Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	426	47772	8.94	0	Secreted	NA	NA	NA	Belongs to the immunoglobulin superfamily. CEA family.	Cell surface interactions at the vascular wall	PE1	19
+NX_Q9UQ80	Proliferation-associated protein 2G4	394	43787	6.13	0	Cytoplasm;Cytosol;Nucleolus	NA	Suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).;May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival.	Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization.;In cancer cells, isoform 2 is polyubiquitinated leading to its proteasomal degradation and phosphorylation by PKC/PRKCD enhances polyubiquitination.	Belongs to the peptidase M24 family.	Neutrophil degranulation	PE1	12
+NX_Q9UQ84	Exonuclease 1	846	94103	8.59	0	Nucleoplasm;Nucleus	NA	5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.	Phosphorylated upon DNA damage and in response to agents stalling DNA replication, probably by ATM or ATR. Phosphorylation at Ser-454, Thr-621 and Ser-714 is induced upon DNA-damage caused by treatment with hydroxyurea (HU) but not upon IR treatment. The HU-induced EXO1 triple phosphorylation facilitates destabilisation/degradation of the protein.	Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);G2/M DNA damage checkpoint;Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation	PE1	1
+NX_Q9UQ88	Cyclin-dependent kinase 11A	783	91362	5.28	0	Cytoplasm;Nucleus	NA	Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.	During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins.	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	Recruitment of mitotic centrosome proteins and complexes	PE1	1
+NX_Q9UQ90	Paraplegin	795	88235	8.79	2	Mitochondrion inner membrane	Spastic paraplegia 7, autosomal recessive	ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (PubMed:26387735).	Upon import into the mitochondrion, the N-terminal transit peptide is cleaved by the mitochondrial-processing peptidase (MPP) to generate an intermediate form which undergoes a second proteolytic cleavage mediated by proteases AFG3L1 and/or AFG3L2 removing an additional N-terminal fragment to generate the proteolytically active mature form.	In the N-terminal section; belongs to the AAA ATPase family.;In the C-terminal section; belongs to the peptidase M41 family.	Processing of SMDT1	PE1	16
+NX_Q9UQB3	Catenin delta-2	1225	132656	7.78	0	Golgi apparatus;Perikaryon;Cell junction;Adherens junction;Nucleoplasm;Dendrite;Nucleus	NA	Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.	Phosphorylated by CDK5 (By similarity). Phosphorylated by GSK3B (PubMed:19706605).;O-glycosylated.;CTNND2 is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the beta-catenin family.	NA	PE1	5
+NX_Q9UQB8	Brain-specific angiogenesis inhibitor 1-associated protein 2	552	60868	8.99	0	Cytoplasm;Cell membrane;Membrane;Filopodium;Ruffle;Cytosol;Cytoskeleton	NA	Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.	Phosphorylated on tyrosine residues by INSR in response to insulin treatment.	NA	Adherens junction;Regulation of actin cytoskeleton;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;VEGFA-VEGFR2 Pathway	PE1	17
+NX_Q9UQB9	Aurora kinase C	309	35591	8.96	0	Centromere;Spindle;Nucleus;Chromosome	Spermatogenic failure 5	Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.	NA	PE1	19
+NX_Q9UQC2	GRB2-associated-binding protein 2	676	74458	8.54	0	Cytoplasm;Cell membrane	NA	Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.	Dephosphorylated by PTPN11.;Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.;GAB2 is phosphorylated by HCK;GAB2 is phosphorylated by SYK	Belongs to the GAB family.	Osteoclast differentiation;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Chronic myeloid leukemia;PI3K Cascade;Role of LAT2/NTAL/LAB on calcium mobilization;Interleukin receptor SHC signaling;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;RET signaling;Interleukin-15 signaling;FLT3 Signaling;STAT5 Activation	PE1	11
+NX_Q9UQC9	Calcium-activated chloride channel regulator 2	943	103941	6.56	1	Basal cell membrane;Cell membrane;Cell junction;Secreted;Nucleoplasm	NA	Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.	N-glycosylated.;The 141 kDa mature form is autoproteolytically cleaved by the metalloprotease domain, producing a 109 kDa form and a 35 kDa form. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.	Belongs to the CLCR family.	Olfactory transduction;Pancreatic secretion;Stimuli-sensing channels	PE1	1
+NX_Q9UQD0	Sodium channel protein type 8 subunit alpha	1980	225280	5.95	24	Cytoplasmic vesicle;Cell junction;Axon;Cell membrane	Cognitive impairment with or without cerebellar ataxia;Epileptic encephalopathy, early infantile, 13;Seizures, benign familial infantile, 5;Myoclonus, familial, 2	In macrophages and melanoma cells, may participate in the control of podosome and invadopodia formation.;Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	May be ubiquitinated by NEDD4L; which would promote its endocytosis.;Phosphorylation at Ser-1497 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	12
+NX_Q9UQE7	Structural maintenance of chromosomes protein 3	1217	141542	6.77	0	Nucleoplasm;Centromere;Nucleus;Chromosome	Cornelia de Lange syndrome 3	Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.	Phosphorylated at Ser-1083 in a SPO11-dependent manner.;Acetylation at Lys-105 and Lys-106 by ESCO1 is important for genome stability and S phase sister chromatid cohesion. Regulated by DSCC1, it is required for processive DNA synthesis, coupling sister chromatid cohesion establishment during S phase to DNA replication. Deacetylation by HDAC8, regulates release of the cohesin complex from chromatin.	Belongs to the SMC family. SMC3 subfamily.	Cell cycle;Oocyte meiosis;Separation of Sister Chromatids;SUMOylation of DNA damage response and repair proteins;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion;Meiotic synapsis;Estrogen-dependent gene expression	PE1	10
+NX_Q9UQF0	Syncytin-1	538	59866	8.8	1	Virion;Cell membrane	NA	Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.;This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).	Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as an inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The intracytoplasmic tail cleavage by the viral protease that is required for the fusiogenic activity of some retroviruses envelope proteins seems to have been lost during evolution.;The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.	Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.	NA	PE1	7
+NX_Q9UQF2	C-Jun-amino-terminal kinase-interacting protein 1	711	77524	4.87	0	Cytoplasm;Endoplasmic reticulum membrane;Cell membrane;Mitochondrion membrane;Perinuclear region;Nucleus	Diabetes mellitus, non-insulin-dependent	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells.	Phosphorylated by MAPK8, MAPK9 and MAPK10. Phosphorylation on Thr-103 is also necessary for the dissociation and activation of MAP3K12. Phosphorylated by isoform 1 and isoform 2 of VRK2. Hyperphosphorylated during mitosis following activation of stress-activated and MAP kinases.;Ubiquitinated. Two preliminary events are required to prime for ubiquitination; phosphorylation and an increased in intracellular calcium concentration. Then, the calcium influx initiates ubiquitination and degradation by the ubiquitin-proteasome pathway.;MAPK8IP1 is phosphorylated by MAPK9 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the JIP scaffold family.	MAPK signaling pathway	PE1	11
+NX_Q9UQG0	Endogenous retrovirus group K member 11 Pol protein	969	109665	9.15	0	NA	NA	Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity).	NA	Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.	NA	PE2	3
+NX_Q9UQK1	Protein phosphatase 1 regulatory subunit 3C	317	36445	7.15	0	NA	NA	Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.	Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner.	NA	Insulin signaling pathway;Glycogen synthesis;Myoclonic epilepsy of Lafora	PE1	10
+NX_Q9UQL6	Histone deacetylase 5	1122	121978	5.83	0	Golgi apparatus;Cytoplasm;Nucleus speckle;Cytosol;Nucleus	NA	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758).	Ubiquitinated. Polyubiquitination however does not lead to its degradation.;Phosphorylated by AMPK, CaMK1, SIK1 and PRKD1 at Ser-259 and Ser-498. The phosphorylation is required for the export to the cytoplasm and inhibition. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylated by GRK5, leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription (By similarity).;HDAC5 is phosphorylated by GRK5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the histone deacetylase family. HD type 2 subfamily.	Notch-HLH transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Regulation of PTEN gene transcription	PE1	17
+NX_Q9UQM7	Calcium/calmodulin-dependent protein kinase type II subunit alpha	478	54088	6.61	0	Dendritic spine;Dendrite;Postsynaptic density;Synapse	Mental retardation, autosomal recessive 63;Mental retardation, autosomal dominant 53	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378).	Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state.	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.	ErbB signaling pathway;Calcium signaling pathway;Oocyte meiosis;Wnt signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Olfactory transduction;GnRH signaling pathway;Melanogenesis;Gastric acid secretion;Tuberculosis;Glioma;RAF/MAP kinase cascade;Ion transport by P-type ATPases;Interferon gamma signaling;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;HSF1-dependent transactivation;RAF activation;Ca2+ pathway;Trafficking of AMPA receptors;CaMK IV-mediated phosphorylation of CREB;Phase 0 - rapid depolarisation;Ion homeostasis;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Regulation of MECP2 expression and activity;Assembly and cell surface presentation of NMDA receptors;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation	PE1	5
+NX_Q9UQN3	Charged multivesicular body protein 2b	213	23907	8.81	0	Cytoplasm;Cytosol;Nucleus;Late endosome membrane	Amyotrophic lateral sclerosis 17;Frontotemporal dementia, chromosome 3-linked	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.	NA	Belongs to the SNF7 family.	Endocytosis;Macroautophagy;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	3
+NX_Q9UQP3	Tenascin-N	1299	144034	5.41	0	Extracellular matrix	NA	Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).	NA	Belongs to the tenascin family.	Focal adhesion;ECM-receptor interaction;ECM proteoglycans	PE1	1
+NX_Q9UQQ1	Aminopeptidase NAALADL1	740	80558	5.2	1	Apical cell membrane;Cytosol	NA	Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position (PubMed:25752612). Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity (PubMed:25752612).	N-glycosylated.	Belongs to the peptidase M28 family. M28B subfamily.	NA	PE1	11
+NX_Q9UQQ2	SH2B adapter protein 3	575	63225	6.75	0	Nucleoplasm	Diabetes mellitus, insulin-dependent;Celiac disease 13	Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.	Tyrosine phosphorylated by LCK.	Belongs to the SH2B adapter family.	Neurotrophin signaling pathway;Factors involved in megakaryocyte development and platelet production;Regulation of KIT signaling	PE1	12
+NX_Q9UQR0	Sex comb on midleg-like protein 2	700	77257	8.79	0	Nucleus;Cytosol;Nucleolus	NA	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).	NA	Belongs to the SCM family.	NA	PE1	X
+NX_Q9UQR1	Zinc finger protein 148	794	88976	6.03	0	Golgi apparatus;Nucleoplasm;Nucleus	Global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies	Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.	Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes (By similarity).	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	3
+NX_Q9UQV4	Lysosome-associated membrane glycoprotein 3	416	44346	8.64	1	Cytoplasmic vesicle membrane;Lysosome membrane;Cytoplasmic vesicle	NA	May play a role in dendritic cell function and in adaptive immunity.	NA	Belongs to the LAMP family.	Lysosome	PE1	3
+NX_Q9WJR5	Endogenous retrovirus group K member 19 Pol protein	959	108106	8.99	0	NA	NA	Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.	NA	Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.	NA	PE2	19
+NX_Q9XRX5	HERV-H LTR-associating protein 3	114	12913	9.14	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	1
+NX_Q9Y210	Short transient receptor potential channel 6	931	106326	6.24	6	Cell membrane	Focal segmental glomerulosclerosis 2	Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.	Phosphorylated by FYN, leading to an increase of TRPC6 channel activity.;TRPC6 is phosphorylated by FYN (Phosphotyrosine:PTM-0255)	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.	TRP channels;Effects of PIP2 hydrolysis;Role of second messengers in netrin-1 signaling;Elevation of cytosolic Ca2+ levels	PE1	11
+NX_Q9Y215	Acetylcholinesterase collagenic tail peptide	455	47766	8.42	0	Cell junction;Synapse;Cell membrane	Myasthenic syndrome, congenital, 5	Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.	The triple-helical tail is stabilized by disulfide bonds at each end.	Belongs to the COLQ family.	NA	PE1	3
+NX_Q9Y216	Myotubularin-related protein 7	660	75833	5.94	0	Nucleoplasm;Cytosol;Cytoplasm;Endomembrane system	NA	Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Fructose and mannose metabolism;Synthesis of PIPs at the late endosome membrane;Synthesis of IP2, IP, and Ins in the cytosol	PE1	8
+NX_Q9Y217	Myotubularin-related protein 6	621	71968	7.59	0	Cytoplasm;Endoplasmic reticulum-Golgi intermediate compartment;Endoplasmic reticulum;Ruffle membrane;Perinuclear region	NA	Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598). Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.	Fructose and mannose metabolism;Synthesis of PIPs at the plasma membrane	PE1	13
+NX_Q9Y219	Protein jagged-2	1238	133367	5.53	1	Membrane;Cytoplasmic vesicle;Cytosol	NA	Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).	NA	NA	Notch signaling pathway;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant;Constitutive Signaling by NOTCH1 HD Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus	PE1	14
+NX_Q9Y221	60S ribosome subunit biogenesis protein NIP7 homolog	180	20463	8.66	0	Nucleoplasm;Nucleolus	NA	Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.	NA	Belongs to the NIP7 family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	16
+NX_Q9Y222	Cyclin-D-binding Myb-like transcription factor 1	760	84471	4.5	0	Nucleoplasm;Nucleus	NA	Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity).;May antagonize transcriptional activation by isoform 1.;May cooperate with MYB to activate transcription of the ANPEP gene.	Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex.	Belongs to the DMTF1 family.	NA	PE1	7
+NX_Q9Y223	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	722	79275	6.32	0	Cytoplasm;Cytosol	Sialuria;Nonaka myopathy	Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.	Phosphorylated by PKC.	In the N-terminal section; belongs to the UDP-N-acetylglucosamine 2-epimerase family.;In the C-terminal section; belongs to the ROK (NagC/XylR) family.	Amino-sugar metabolism; N-acetylneuraminate biosynthesis.;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Sialic acid metabolism;Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2	PE1	9
+NX_Q9Y224	RNA transcription, translation and transport factor protein	244	28068	6.19	0	Cytoplasm;Nucleoplasm;Centrosome;Cytosol;Perinuclear region;Nucleus	NA	RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264).;(Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157).	NA	Belongs to the RTRAF family.	tRNA processing in the nucleus	PE1	14
+NX_Q9Y225	RING finger protein 24	148	17210	8.88	1	Golgi apparatus;Golgi apparatus membrane	NA	May play a role in TRPCs intracellular trafficking.	NA	NA	NA	PE1	20
+NX_Q9Y226	Solute carrier family 22 member 13	551	60862	7.98	12	Membrane	NA	NA	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Nicotinamide salvaging	PE1	3
+NX_Q9Y227	Ectonucleoside triphosphate diphosphohydrolase 4	616	70255	8.55	2	Autophagosome membrane;Cytoplasmic vesicle;Golgi apparatus membrane	NA	Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.	NA	Belongs to the GDA1/CD39 NTPase family.	Purine metabolism;Pyrimidine metabolism;Lysosome;Phosphate bond hydrolysis by NTPDase proteins	PE1	8
+NX_Q9Y228	TRAF3-interacting JNK-activating modulator	551	63626	8.79	1	Membrane;Cytoplasmic vesicle	NA	May function as an adapter molecule that regulates TRAF3-mediated JNK activation.	NA	NA	NA	PE1	1
+NX_Q9Y230	RuvB-like 2	463	51157	5.49	0	Cytoplasm;Nucleus matrix;Membrane;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026).	NA	Belongs to the RuvB family.	HATs acetylate histones;Telomere Extension By Telomerase	PE1	19
+NX_Q9Y231	Alpha-(1,3)-fucosyltransferase 9	359	42071	7.6	1	Golgi stack membrane;Nucleoplasm;Cytosol;Cytoskeleton	NA	Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.	NA	Belongs to the glycosyltransferase 10 family.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;Glycosphingolipid biosynthesis - lacto and neolacto series;Glycosphingolipid biosynthesis - globo series;Metabolic pathways;Lewis blood group biosynthesis	PE1	6
+NX_Q9Y232	Chromodomain Y-like protein	598	66482	9.5	0	Nucleus speckle;Nucleus;Chromosome	NA	Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain (PubMed:19808672).;Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity).;Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin.	NA	NA	NA	PE1	6
+NX_Q9Y233	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	779	88412	6.15	0	Cytoplasm	Dyskinesia, limb and orofacial, infantile-onset;Striatal degeneration, autosomal dominant 2	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.	Phosphorylated on Thr-16.	Belongs to the cyclic nucleotide phosphodiesterase family.	Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.;Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.;Purine metabolism;G alpha (s) signalling events;cGMP effects	PE1	6
+NX_Q9Y234	Lipoyltransferase 1, mitochondrial	373	42479	8.66	0	Mitochondrion	Lipoyltransferase 1 deficiency	Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes.	NA	Belongs to the LplA family.	Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.;Lipoic acid metabolism;Metabolic pathways;Glyoxylate metabolism and glycine degradation	PE1	2
+NX_Q9Y235	C->U-editing enzyme APOBEC-2	224	25703	4.81	0	NA	NA	Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.	NA	Belongs to the cytidine and deoxycytidylate deaminase family.	mRNA Editing: C to U Conversion;Formation of the Editosome	PE1	6
+NX_Q9Y236	Oxidative stress-induced growth inhibitor 2	505	56672	7.05	0	Nucleolus	NA	May be involved in meiosis or the maturation of germ cells.	NA	Belongs to the OKL38 family.	NA	PE1	8
+NX_Q9Y237	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	131	13810	9.78	0	Cytoplasm;Mitochondrion;Mitochondrion matrix;Nucleolus;Nucleoplasm;Spindle	NA	Binds to double-stranded DNA.;Is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.	Phosphorylated.;Phosphorylation occurs both in the nucleus and the cytoplasm.;Phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus.;Is sumoylated with SUMO2 and SUMO3.	Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.	NA	PE1	X
+NX_Q9Y238	Deleted in lung and esophageal cancer protein 1	1755	195684	5.92	0	Cytoplasm;Cytosol	Esophageal cancer;Lung cancer	May act as a tumor suppressor by inhibiting cell proliferation.	NA	NA	NA	PE1	3
+NX_Q9Y239	Nucleotide-binding oligomerization domain-containing protein 1	953	107691	6.71	0	Cytoplasm;Mitochondrion;Cell membrane;Basolateral cell membrane;Apical cell membrane	NA	Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.	Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF34 promotes proteasomal degradation and thereby negatively regulates NOD1 for instance in NF-kappa-B activition.	NA	NOD-like receptor signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Pertussis;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Ovarian tumor domain proteases;Interleukin-1 signaling	PE1	7
+NX_Q9Y240	C-type lectin domain family 11 member A	323	35695	5.06	0	Cytoplasm;Centrosome;Secreted	NA	Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed:27976999). Important for repair and maintenance of adult bone (By similarity).	O-glycosylated. Probably sulfated on the O-glycans.	NA	NA	PE1	19
+NX_Q9Y241	HIG1 domain family member 1A, mitochondrial	93	10143	9.79	2	Mitochondrion membrane;Nucleoplasm;Mitochondrion inner membrane;Mitochondrion	NA	Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes.	NA	NA	Regulation of gene expression by Hypoxia-inducible Factor	PE1	3
+NX_Q9Y242	Transcription factor 19	345	37184	8.71	0	Nucleus	NA	Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.	NA	NA	NA	PE1	6
+NX_Q9Y243	RAC-gamma serine/threonine-protein kinase	479	55775	5.72	0	Membrane;Cytoplasm;Cytosol;Nucleus	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.	Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.;Phosphorylation on Thr-305 and Ser-472 is required for full activity.;O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction between AKT and PDK1.	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.	MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;mTOR signaling pathway;Apoptosis;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Tight junction;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Adipocytokine signaling pathway;Carbohydrate digestion and absorption;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Hepatitis C;Measles;Influenza A;HTLV-I infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;PIP3 activates AKT signaling;G beta:gamma signalling through PI3Kgamma;VEGFR2 mediated vascular permeability;CD28 dependent PI3K/Akt signaling;Cyclin E associated events during G1/S transition;TP53 Regulates Metabolic Genes;Activation of BAD and translocation to mitochondria;Cyclin A:Cdk2-associated events at S phase entry;AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;CTLA4 inhibitory signaling;AKT phosphorylates targets in the cytosol;Downregulation of ERBB2:ERBB3 signaling;Negative regulation of the PI3K/AKT network;AKT-mediated inactivation of FOXO1A;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Association with Co-factors;RAB GEFs exchange GTP for GDP on RABs;Regulation of PTEN stability and activity;RUNX2 regulates genes involved in cell migration;Estrogen-dependent nuclear events downstream of ESR-membrane signaling;Regulation of localization of FOXO transcription factors	PE1	1
+NX_Q9Y244	Proteasome maturation protein	141	15789	5.01	0	Microsome membrane;Cytoplasm;Nucleus speckle;Cytosol;Nucleus	Proteasome-associated autoinflammatory syndrome 2;Keratosis linearis with ichthyosis congenita and sclerosing keratoderma	Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.	NA	Belongs to the POMP/UMP1 family.	Proteasome	PE1	13
+NX_Q9Y247	Protein FAM50B	325	38709	8.9	0	Nucleoplasm;Cytoskeleton	NA	NA	NA	Belongs to the FAM50 family.	NA	PE1	6
+NX_Q9Y248	DNA replication complex GINS protein PSF2	185	21428	5.29	0	Nucleoplasm;Nucleus	NA	The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.	NA	Belongs to the GINS2/PSF2 family.	Unwinding of DNA	PE1	16
+NX_Q9Y250	Leucine zipper putative tumor suppressor 1	596	66613	6.64	0	Cytoplasm;Dendritic spine;Cell membrane;Nucleolus;Postsynaptic density;Synapse	Esophageal cancer	Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.	Phosphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression.	Belongs to the LZTS family.	NA	PE1	8
+NX_Q9Y251	Heparanase	543	61149	9.32	0	Lysosome membrane;Secreted;Nucleoplasm;Cytoplasmic vesicle;Nucleus	NA	Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.	Proteolytically processed. The cleavage of the 65 kDa form leads to the generation of a linker peptide, and 8 kDa and 50 kDa products. The active form, the 8/50 kDa heterodimer, is resistant to degradation. Complete removal of the linker peptide appears to be a prerequisite to the complete activation of the enzyme.;N-glycosylated. Glycosylation of the 50 kDa subunit appears to be essential for its solubility.	Belongs to the glycosyl hydrolase 79 family.	Glycosaminoglycan degradation;Metabolic pathways;HS-GAG degradation;Neutrophil degranulation	PE1	4
+NX_Q9Y252	E3 ubiquitin-protein ligase RNF6	685	78091	9.16	0	Cytoplasm;Nucleus membrane;PML body;Axon;Nucleus	Esophageal cancer	E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.	NA	Belongs to the RNF12 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	13
+NX_Q9Y253	DNA polymerase eta	713	78413	8.74	0	Nucleoplasm;Cytosol;Nucleus	Xeroderma pigmentosum variant type	DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586).	Monoubiquitinated by RCHY1/PIRH2; ubiquitination inhibits the ability of PolH to interact with PCNA and to bypass UV-induced lesions.	Belongs to the DNA polymerase type-Y family.	Fanconi anemia pathway;Translesion Synthesis by POLH;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR)	PE1	6
+NX_Q9Y255	PRELI domain-containing protein 1, mitochondrial	219	25181	9.56	0	Nucleoplasm;Mitochondrion intermembrane space;Mitochondrion	NA	Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.	NA	NA	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	PE1	5
+NX_Q9Y256	CAAX prenyl protease 2	329	35833	8.33	7	Endoplasmic reticulum membrane	NA	Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068).	Ubiquitinated. Undergoes 'Lys-48'-and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.	Belongs to the peptidase U48 family.	Ub-specific processing proteases	PE1	11
+NX_Q9Y257	Potassium channel subfamily K member 6	313	33747	6.05	4	Membrane;Cytosol;Cytoskeleton;Cell membrane	NA	Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.	NA	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK);Phase 4 - resting membrane potential	PE1	19
+NX_Q9Y258	C-C motif chemokine 26	94	10648	10.22	0	Secreted	NA	Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309).	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway	PE1	7
+NX_Q9Y259	Choline/ethanolamine kinase	395	45271	5.35	0	Cytosol	Muscular dystrophy, congenital, megaconial type	Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis.	NA	Belongs to the choline/ethanolamine kinase family.	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PC;Synthesis of PE	PE1	22
+NX_Q9Y261	Hepatocyte nuclear factor 3-beta	457	48306	8.82	0	Cytoplasm;Nucleoplasm;Cell junction;Nucleus	NA	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.	Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.	NA	Maturity onset diabetes of the young;Regulation of gene expression in beta cells	PE1	20
+NX_Q9Y262	Eukaryotic translation initiation factor 3 subunit L	564	66727	5.93	0	Nucleoplasm;Cytoplasm;Nucleolus	NA	(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).;Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).	NA	Belongs to the eIF-3 subunit L family.	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit	PE1	22
+NX_Q9Y263	Phospholipase A-2-activating protein	795	87157	5.96	0	Cytoplasm;Cell membrane;Nucleoplasm;Synapse;Cytosol;Nucleus	Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies	Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).	NA	Belongs to the WD repeat PLAP family.	Protein processing in endoplasmic reticulum	PE1	9
+NX_Q9Y264	Angiopoietin-4	503	56849	9.1	0	Secreted	NA	Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.	NA	NA	Tie2 Signaling	PE1	20
+NX_Q9Y265	RuvB-like 1	456	50228	6.02	0	Cytoplasm;Nucleus matrix;Membrane;Nucleoplasm;Centrosome;Cytosol	NA	Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:17157868). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). Essential for cell proliferation (PubMed:14506706). May be able to bind plasminogen at cell surface and enhance plasminogen activation (PubMed:11027681).	NA	Belongs to the RuvB family.	Wnt signaling pathway;HATs acetylate histones;Formation of the beta-catenin:TCF transactivating complex;Deposition of new CENPA-containing nucleosomes at the centromere;Telomere Extension By Telomerase;DNA Damage Recognition in GG-NER;UCH proteinases;Ub-specific processing proteases	PE1	3
+NX_Q9Y266	Nuclear migration protein nudC	331	38243	5.27	0	Cytoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.	Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.	Belongs to the nudC family.	Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Mitotic Telophase/Cytokinesis	PE1	1
+NX_Q9Y267	Solute carrier family 22 member 14	594	66684	8.71	12	Membrane	NA	NA	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	NA	PE2	3
+NX_Q9Y271	Cysteinyl leukotriene receptor 1	337	38541	9.43	7	Cell membrane	NA	Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.	NA	Belongs to the G-protein coupled receptor 1 family.	Calcium signaling pathway;Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Leukotriene receptors	PE1	X
+NX_Q9Y272	Dexamethasone-induced Ras-related protein 1	281	31642	9.15	0	Nucleoplasm;Perinuclear region;Nucleus;Cell membrane	NA	Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).	S-nitrosylation stimulates guanine-nucleotide exchange activity.	Belongs to the small GTPase superfamily. RasD family.	NA	PE1	17
+NX_Q9Y274	Type 2 lactosamine alpha-2,3-sialyltransferase	331	38214	9.13	1	Golgi apparatus membrane	NA	Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.	NA	Belongs to the glycosyltransferase 29 family.	Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Sialic acid metabolism;Keratan sulfate biosynthesis;Pre-NOTCH Processing in Golgi;Lewis blood group biosynthesis	PE1	3
+NX_Q9Y275	Tumor necrosis factor ligand superfamily member 13B	285	31223	5.92	1	Secreted;Cell membrane	NA	Seems to inhibit isoform 1 secretion and bioactivity.;Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.;Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.	Is not efficiently shed from the membrane unlike isoform 1.;N-glycosylated.;The soluble form derives from the membrane form by proteolytic processing.	Belongs to the tumor necrosis factor family.	Cytokine-cytokine receptor interaction;Intestinal immune network for IgA production;Rheumatoid arthritis;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;TNFs bind their physiological receptors	PE1	13
+NX_Q9Y276	Mitochondrial chaperone BCS1	419	47534	8.63	1	Mitochondrion inner membrane	Bjoernstad syndrome;Mitochondrial complex III deficiency, nuclear 1;GRACILE syndrome	Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex.	NA	Belongs to the AAA ATPase family. BCS1 subfamily.	Mitochondrial protein import	PE1	2
+NX_Q9Y277	Voltage-dependent anion-selective channel protein 3	283	30659	8.84	19	Mitochondrion outer membrane;Mitochondrion	NA	Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	Belongs to the eukaryotic mitochondrial porin family.	Calcium signaling pathway;Parkinson's disease;Huntington's disease;HTLV-I infection;Ub-specific processing proteases;Mitochondrial calcium ion transport	PE1	8
+NX_Q9Y278	Heparan sulfate glucosamine 3-O-sulfotransferase 2	367	41501	9.93	1	Golgi apparatus membrane	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.	NA	Belongs to the sulfotransferase 1 family.	Glycosaminoglycan biosynthesis - heparan sulfate;HS-GAG biosynthesis	PE1	16
+NX_Q9Y279	V-set and immunoglobulin domain-containing protein 4	399	43987	5.93	1	Membrane;Cytosol;Nucleolus;Cell membrane	NA	Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.	NA	NA	NA	PE1	X
+NX_Q9Y281	Cofilin-2	166	18737	7.66	0	Cell membrane;Nucleus matrix;Nucleoplasm;Cytosol;Cytoskeleton	Nemaline myopathy 7	Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).	The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.	Belongs to the actin-binding proteins ADF family.	Axon guidance;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Pertussis	PE1	14
+NX_Q9Y282	Endoplasmic reticulum-Golgi intermediate compartment protein 3	383	43222	5.68	2	Endoplasmic reticulum-Golgi intermediate compartment membrane;Nucleoplasm;cis-Golgi network membrane;Endoplasmic reticulum membrane	NA	Possible role in transport between endoplasmic reticulum and Golgi.	NA	Belongs to the ERGIC family.	NA	PE1	20
+NX_Q9Y283	Inversin	1065	117826	9.43	0	Cytoplasm;Cilium;Membrane;Cytosol;Spindle;Nucleus;Cytoskeleton	Nephronophthisis 2	Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).	May be ubiquitinated via its interaction with APC2.;Hydroxylated at Asn-75, most probably by HIF1AN.	NA	NA	PE1	9
+NX_Q9Y284	Protein Asterix	106	12068	8.41	2	Membrane;Endoplasmic reticulum	NA	NA	NA	Belongs to the Asterix family.	NA	PE1	19
+NX_Q9Y285	Phenylalanine--tRNA ligase alpha subunit	508	57564	7.31	0	Cytoplasm;Cytosol	NA	NA	NA	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.	Aminoacyl-tRNA biosynthesis;Cytosolic tRNA aminoacylation	PE1	19
+NX_Q9Y286	Sialic acid-binding Ig-like lectin 7	467	51143	6.89	1	Membrane	NA	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).	Tyrosine phosphorylated.	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PE1	19
+NX_Q9Y287	Integral membrane protein 2B	266	30338	5	1	Golgi apparatus;Cell membrane;Endosome membrane;Secreted;Golgi apparatus membrane;Cytoplasmic vesicle	Cerebral amyloid angiopathy, ITM2B-related 1;Retinal dystrophy with inner retinal dysfunction and ganglion cell abnormalities;Cerebral amyloid angiopathy, ITM2B-related 2	Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.;Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.;Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.	Glycosylation at Asn-170 is important for cell surface localization, but doesn't affect furin- and ADAM10-induced proteolytic processing.;The ectodomain C-terminal part of the imBRI2 is processed by furin producing a secreted Bri23 peptide and a mature BRI2, membrane form (mBRI2). The remaining part of the ectodomain of mBRI2 containing the BRICHOS domain is cleaved by ADAM10 and is secreted (BRI2C, soluble form). The membrane-bound N-terminal fragment (BRI2C, membrane form) is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted C-peptide and a BRI2 intracellular domain (BRI2 ICD) released in the cytosol. Shedding by ADAM10 facilitates intramembrane cleavage but is not absolutely required for BRI2 ICD generation.	Belongs to the ITM2 family.	Amyloid fiber formation	PE1	13
+NX_Q9Y289	Sodium-dependent multivitamin transporter	635	68642	8.61	13	Membrane;Cell junction	NA	Transports pantothenate, biotin and lipoate in the presence of sodium.	NA	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Vitamin digestion and absorption;Biotin transport and metabolism;Vitamin B5 (pantothenate) metabolism;Transport of vitamins, nucleosides, and related molecules	PE1	2
+NX_Q9Y291	28S ribosomal protein S33, mitochondrial	106	12629	10.11	0	Mitochondrion	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mS33 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	7
+NX_Q9Y294	Histone chaperone ASF1A	204	22969	4.29	0	Nucleoplasm;Nucleus	NA	Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.	Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation.	Belongs to the ASF1 family.	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	PE1	6
+NX_Q9Y295	Developmentally-regulated GTP-binding protein 1	367	40542	9	0	Cytoplasm;Cytosol;Nucleus	NA	Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639).	Sumoylated by UBE2I in response to MEKK1-mediated stimuli.;Phosphorylated at Thr-100 by STK16.;Hydroxylated (with S stereochemistry) at C-3 of Lys-22 by JMJD7; this modification hinders trypsin-catalyzed proteolysis in vitro.;Polyubiquitinated; this modification induces proteolytic degradation and is impaired by interaction with ZC3H15.	Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.	NA	PE1	22
+NX_Q9Y296	Trafficking protein particle complex subunit 4	219	24340	5.84	0	cis-Golgi network;Endoplasmic reticulum;Cytosol	NA	May play a role in vesicular transport from endoplasmic reticulum to Golgi.	NA	Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.	Syndecan interactions;COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs	PE1	11
+NX_Q9Y297	F-box/WD repeat-containing protein 1A	605	68867	8.3	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:25503564, PubMed:25704143, PubMed:9859996, PubMed:22087322). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14681206, PubMed:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:21258371, PubMed:18354482).	NA	NA	Protein modification; protein ubiquitination.;Oocyte meiosis;Ubiquitin mediated proteolysis;Wnt signaling pathway;Hedgehog signaling pathway;Circadian rhythm - mammal;Shigellosis;Activation of NF-kappaB in B cells;SCF-beta-TrCP mediated degradation of Emi1;Vpu mediated degradation of CD4;Degradation of beta-catenin by the destruction complex;FCERI mediated NF-kB activation;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;Antigen processing: Ubiquitination &amp; Proteasome degradation;Regulation of PLK1 Activity at G2/M Transition;Downstream TCR signaling;Circadian Clock;Prolactin receptor signaling;Deactivation of the beta-catenin transactivating complex;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neddylation;Interleukin-1 signaling	PE1	10
+NX_Q9Y2A4	Zinc finger protein 443	671	77516	9.3	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9Y2A7	Nck-associated protein 1	1128	128790	6.18	1	Cytosol;Lamellipodium membrane;Cell membrane	NA	Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.	NA	Belongs to the HEM-1/HEM-2 family.	Regulation of actin cytoskeleton;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;VEGFA-VEGFR2 Pathway	PE1	2
+NX_Q9Y2A9	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3	372	42534	8.96	1	Golgi apparatus membrane	NA	Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191).	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;O-linked glycosylation of mucins;Keratan sulfate biosynthesis	PE1	19
+NX_Q9Y2B0	Protein canopy homolog 2	182	20652	4.81	0	Endoplasmic reticulum;Cytosol	NA	Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.	NA	Belongs to the canopy family.	NA	PE1	12
+NX_Q9Y2B1	Ribitol-5-phosphate xylosyltransferase 1	443	51146	8.57	1	Golgi apparatus;Nucleoplasm;Golgi apparatus membrane	Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A10	UDP-xylosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:27601598, PubMed:27733679) (Probable). Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan (PubMed:27733679, PubMed:29477842) (Probable).	NA	Belongs to the RXYLT1 family.	Protein modification; protein glycosylation.	PE1	12
+NX_Q9Y2B2	N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase	252	28531	8.28	1	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane	Coloboma, congenital heart disease, ichthyosiform dermatosis, mental retardation and ear anomalies syndrome	Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.	NA	Belongs to the PIGL family.	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.;Glycosylphosphatidylinositol(GPI)-anchor biosynthesis;Metabolic pathways;Synthesis of glycosylphosphatidylinositol (GPI)	PE1	17
+NX_Q9Y2B4	TP53-target gene 5 protein	290	34019	10.56	0	Cytoplasm;Nucleus	NA	May play a significant role in p53/TP53-mediating signaling pathway.	NA	NA	NA	PE1	20
+NX_Q9Y2B5	VPS9 domain-containing protein 1	631	68956	7.1	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	16
+NX_Q9Y2B9	cAMP-dependent protein kinase inhibitor gamma	76	7910	4.11	0	Nucleoplasm;Cytosol	NA	Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.	NA	Belongs to the PKI family.	NA	PE1	20
+NX_Q9Y2C2	Uronyl 2-sulfotransferase	406	47673	8.88	1	Golgi apparatus membrane	NA	Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.	NA	Belongs to the sulfotransferase 3 family.	Glycosaminoglycan biosynthesis - chondroitin sulfate;Dermatan sulfate biosynthesis	PE1	6
+NX_Q9Y2C3	Beta-1,3-galactosyltransferase 5	310	36189	9.03	1	Golgi apparatus membrane	NA	Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Glycosphingolipid biosynthesis - globo series;Metabolic pathways;Lewis blood group biosynthesis	PE1	21
+NX_Q9Y2C4	Nuclease EXOG, mitochondrial	368	41085	8.45	0	Mitochondrion inner membrane;Mitochondrion	NA	Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.	NA	Belongs to the DNA/RNA non-specific endonuclease family.	NA	PE1	3
+NX_Q9Y2C5	Probable small intestine urate exporter	497	54055	7.45	10	Apical cell membrane;Cell membrane	NA	Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).	NA	Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.	NA	PE2	6
+NX_Q9Y2C9	Toll-like receptor 6	796	91880	6.83	1	Golgi apparatus;Cell membrane;Phagosome membrane;Endoplasmic reticulum;Membrane raft	NA	Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584).	NA	Belongs to the Toll-like receptor family.	Phagosome;Toll-like receptor signaling pathway;Chagas disease (American trypanosomiasis);Tuberculosis;ER-Phagosome pathway;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);Toll Like Receptor TLR6:TLR2 Cascade;Regulation of TLR by endogenous ligand	PE1	4
+NX_Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	317	36434	7.7	0	Mitochondrion	NA	Reversible hydration of carbon dioxide.	NA	Belongs to the alpha-carbonic anhydrase family.	Nitrogen metabolism;Reversible hydration of carbon dioxide	PE1	X
+NX_Q9Y2D1	Cyclic AMP-dependent transcription factor ATF-5	282	30674	4.9	0	Cytoplasm;Nucleoplasm;Centrosome;Cytosol;Nucleus	NA	Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).	Acetylated at Lys-29 by EP300, the acetylation enhances the interaction with CEBPB, DNA-binding and transactivation activity.;Phosphorylated by NLK, probably at Ser-92, Thr-94, Ser-126 and Ser-190.;Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. Cisplatin inhibits ubiquitination and proteasome-mediated degradation by inhibiting the interaction with CDC34 (PubMed:18458088). Ubiquitination and degradation by the proteasome are inhibited by NLK in a kinase-independent manner (PubMed:25512613).	Belongs to the bZIP family.	NA	PE1	19
+NX_Q9Y2D2	UDP-N-acetylglucosamine transporter	325	35985	9.22	8	Golgi apparatus membrane	Arthrogryposis, mental retardation, and seizures	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides.	NA	Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.	Transport of nucleotide sugars;Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS)	PE1	1
+NX_Q9Y2D4	Exocyst complex component 6B	811	94201	6.03	0	Nucleoplasm;Cytosol;Nucleus	Spondyloepimetaphyseal dysplasia with joint laxity, 3	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	NA	Belongs to the SEC15 family.	NA	PE1	2
+NX_Q9Y2D5	A-kinase anchor protein 2	859	94661	5.04	0	NA	NA	Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).	NA	NA	NA	PE1	9
+NX_Q9Y2D8	Afadin- and alpha-actinin-binding protein	614	71236	6.03	0	Cytoplasm;Adherens junction;Centriolar satellite;Cell junction;Cilium basal body;Nucleus	NA	Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449).	NA	Belongs to the ADIP family.	Adherens junction	PE1	1
+NX_Q9Y2D9	Zinc finger protein 652	606	69744	8.92	0	Nucleoplasm;Nucleus	NA	Functions as a transcriptional repressor.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	17
+NX_Q9Y2E4	Disco-interacting protein 2 homolog C	1556	170767	7.12	0	Nucleoplasm;Cytosol;Cytoplasmic vesicle	NA	NA	NA	Belongs to the DIP2 family.	NA	PE1	10
+NX_Q9Y2E5	Epididymis-specific alpha-mannosidase	1009	113979	6.74	0	Secreted	NA	NA	NA	Belongs to the glycosyl hydrolase 38 family.	Other glycan degradation;Lysosomal oligosaccharide catabolism	PE1	4
+NX_Q9Y2E6	E3 ubiquitin-protein ligase DTX4	619	67258	9.65	0	Cytoplasm;Cytoplasmic vesicle	NA	Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.	NA	Belongs to the Deltex family.	Protein modification; protein ubiquitination.;Notch signaling pathway;Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN;IRF3 mediated activation of type 1 IFN;Activated NOTCH1 Transmits Signal to the Nucleus	PE1	11
+NX_Q9Y2E8	Sodium/hydrogen exchanger 8	581	65422	6.07	11	Golgi apparatus membrane	NA	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.	NA	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Sodium/Proton exchangers	PE1	20
+NX_Q9Y2F5	Little elongation complex subunit 1	2266	247891	5.32	0	Cajal body;Nucleoplasm;Nucleus	NA	Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780).	NA	Belongs to the ICE1 family.	RNA polymerase II transcribes snRNA genes	PE1	5
+NX_Q9Y2F9	BTB/POZ domain-containing protein 3	522	58420	7.42	0	Cytoplasmic vesicle;Cytosol;Nucleus	NA	Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity).	NA	NA	NA	PE1	20
+NX_Q9Y2G0	Protein EFR3 homolog B	817	92487	6.26	0	Cytosol;Cell membrane;Cytoskeleton	NA	Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825).	Palmitoylated at its N-terminus, anchoring the protein to the plasma membrane.	Belongs to the EFR3 family.	NA	PE1	2
+NX_Q9Y2G1	Myelin regulatory factor	1151	124397	7.06	1	Cytoplasm;Endoplasmic reticulum membrane;Nucleoplasm;Cytosol;Nucleus	Encephalitis/encephalopathy, mild, with reversible myelin vacuolization;Cardiac-urogenital syndrome	Myelin regulatory factor: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832).;Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.;Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).	Myelin regulatory factor, C-terminal: Glycosylated.;Myelin regulatory factor: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity (PubMed:23966832). Autocatalytic cleavage is inhibited by interaction with TMEM98 (By similarity).	Belongs to the MRF family.	NA	PE1	11
+NX_Q9Y2G2	Caspase recruitment domain-containing protein 8	431	48933	5.1	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.	NA	NA	NOD-like receptor signaling pathway;Formation of apoptosome;Regulation of the apoptosome activity	PE1	19
+NX_Q9Y2G3	Probable phospholipid-transporting ATPase IF	1177	134190	6.52	10	trans-Golgi network;Early endosome;Centriolar satellite;Endoplasmic reticulum;Recycling endosome membrane;Cytosol	NA	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases;Neutrophil degranulation	PE1	3
+NX_Q9Y2G4	Ankyrin repeat domain-containing protein 6	727	79971	9.42	0	Cytoplasmic vesicle	NA	Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.	NA	NA	NA	PE1	6
+NX_Q9Y2G5	GDP-fucose protein O-fucosyltransferase 2	429	49976	6.15	0	Golgi apparatus;Endoplasmic reticulum	NA	Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13.	NA	Belongs to the glycosyltransferase 68 family.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;O-glycosylation of TSR domain-containing proteins	PE1	21
+NX_Q9Y2G7	Zinc finger protein 30 homolog	519	61558	9.16	0	Cytosol;Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9Y2G8	DnaJ homolog subfamily C member 16	782	90591	6.67	1	Membrane;Cytoplasmic vesicle	NA	NA	NA	NA	NA	PE1	1
+NX_Q9Y2G9	Protein strawberry notch homolog 2	1366	150275	6.09	0	NA	NA	Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the proinflammatory cascade (PubMed:18025162).	NA	Belongs to the SBNO family.	NA	PE1	19
+NX_Q9Y2H0	Disks large-associated protein 4	992	108012	6.65	0	Cytoplasm;Cell membrane;Focal adhesion;Membrane;Nucleoplasm;Cytosol	NA	May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.	DLGAP4 is phosphorylated by MAPK8 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the SAPAP family.	Neurexins and neuroligins	PE1	20
+NX_Q9Y2H1	Serine/threonine-protein kinase 38-like	464	54003	6.36	0	Membrane;Cytoplasm;Cytoskeleton	NA	Involved in the regulation of structural processes in differentiating and mature neuronal cells.	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	NA	PE1	12
+NX_Q9Y2H2	Phosphatidylinositide phosphatase SAC2	1132	128407	6.57	0	Cytoplasmic vesicle;Early endosome;Clathrin-coated pit;Recycling endosome	NA	Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).	NA	NA	Synthesis of PIPs at the early endosome membrane	PE1	10
+NX_Q9Y2H5	Pleckstrin homology domain-containing family A member 6	1048	117128	9.15	0	Cytoplasmic vesicle;Cell junction	NA	NA	NA	NA	Synthesis of PIPs at the plasma membrane	PE1	1
+NX_Q9Y2H6	Fibronectin type-III domain-containing protein 3A	1198	131852	6.29	1	Endoplasmic reticulum;Golgi apparatus membrane	NA	Mediates spermatid-Sertoli adhesion during spermatogenesis.	NA	Belongs to the FNDC3 family.	NA	PE1	13
+NX_Q9Y2H8	Zinc finger protein 510	683	79142	9.18	0	Nucleoplasm;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	9
+NX_Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	1570	170677	8.67	0	Cell membrane;Cytoplasmic vesicle;Axon;Dendrite;Cytoskeleton	Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations	Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	NA	PE1	19
+NX_Q9Y2I1	Nischarin	1504	166629	5.04	0	Recycling endosome;Early endosome;Cytoplasm;Cell membrane	NA	Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.	NA	NA	NA	PE1	3
+NX_Q9Y2I2	Netrin-G1	539	60541	5.84	0	Cell membrane	NA	Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.	N-glycosylated.;NTNG1 is phosphorylated by CDKL5 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Axon guidance;Post-translational modification: synthesis of GPI-anchored proteins	PE1	1
+NX_Q9Y2I6	Ninein-like protein	1382	156344	5.01	0	Cytoplasm;Cytosol;Centrosome;Cytoskeleton	NA	Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.	Ubiquitinated by the APC/C complex leading to its degradation.;Phosphorylated by PLK1 which disrupts its centrosome association and interaction with gamma-tubulin.;NINL is phosphorylated by PLK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	NA	Anchoring of the basal body to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;AURKA Activation by TPX2	PE1	20
+NX_Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	2098	237136	6.24	0	Cytoplasmic vesicle;Endosome membrane	Corneal dystrophy, fleck	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.	Phosphorylated in response to insulin at Ser-318 in a protein kinase B (PKB)-dependent manner.	NA	Inositol phosphate metabolism;Phosphatidylinositol signaling system;Phagosome;Regulation of actin cytoskeleton;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane	PE1	2
+NX_Q9Y2I8	WD repeat-containing protein 37	494	54665	6.79	0	Cytoplasm;Cytoskeleton	NA	NA	NA	NA	NA	PE1	10
+NX_Q9Y2I9	TBC1 domain family member 30	924	102743	8.57	0	Cytosol;Cell membrane	NA	GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro.	NA	NA	NA	PE1	12
+NX_Q9Y2J0	Rabphilin-3A	694	76872	8.62	0	Membrane;Dendritic spine;Synaptic vesicle membrane;Postsynaptic cell membrane	NA	Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone (By similarity).	Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation.	NA	NA	PE1	12
+NX_Q9Y2J2	Band 4.1-like protein 3	1087	120678	5.09	0	Cytoplasm;Cell junction;Cytoskeleton;Cell membrane	NA	Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.	NA	NA	Tight junction;Neurexins and neuroligins	PE1	18
+NX_Q9Y2J4	Angiomotin-like protein 2	779	85764	6.81	0	Recycling endosome;Cell junction	NA	Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.	Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway.	Belongs to the angiomotin family.	Signaling by Hippo	PE1	3
+NX_Q9Y2J8	Protein-arginine deiminase type-2	665	75564	5.4	0	Cytoplasm	NA	Catalyzes the deimination of arginine residues of proteins.	NA	Belongs to the protein arginine deiminase family.	Chromatin modifying enzymes;Neutrophil degranulation	PE1	1
+NX_Q9Y2K1	Zinc finger and BTB domain-containing protein 1	713	82016	5.97	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).	Sumoylated with SUMO2 at Lys-328 and to a lesser extent at Lys-265. Sumoylation inhibits its transcriptional repression activity and regulates its subcellular localization.	NA	NA	PE1	14
+NX_Q9Y2K2	Serine/threonine-protein kinase SIK3	1321	144851	6.3	0	Nucleoplasm;Cytoplasm	Spondyloepimetaphyseal dysplasia, Krakow type	Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).	Phosphorylated at Thr-221 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552). Phosphorylation at Thr-221 is inhibited in response to PTHLH/PTHrP (PubMed:30232230). Phosphorylated at Thr-469 and Ser-551 in response to cAMP signaling (Probable).	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.	NA	PE1	11
+NX_Q9Y2K3	Myosin-15	1946	224619	5.67	0	Myofibril	NA	Muscle contraction.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tight junction;Viral myocarditis	PE1	3
+NX_Q9Y2K5	R3H domain-containing protein 2	976	106999	8.99	0	Nucleoplasm;Nucleus	NA	NA	NA	NA	NA	PE1	12
+NX_Q9Y2K6	Ubiquitin carboxyl-terminal hydrolase 20	914	102003	5.75	0	Cell membrane;Nucleoplasm;Centrosome;Cytosol;Perinuclear region	NA	Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.	Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.	Belongs to the peptidase C19 family. USP20/USP33 subfamily.	Ub-specific processing proteases	PE1	9
+NX_Q9Y2K7	Lysine-specific demethylase 2A	1162	132793	7.73	0	Nucleoplasm	NA	Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310).	NA	Belongs to the JHDM1 histone demethylase family.	HDMs demethylate histones	PE1	11
+NX_Q9Y2K9	Syntaxin-binding protein 5-like	1186	131887	6.51	0	Membrane;Cytoplasm;Cell membrane	NA	Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045).	Phosphorylated, leading to STXBP5L increased turnover and subsequent de-repression of insulin secretion (By similarity). Phosphorylated on serine residues in response to glucose or phorbol esters (By similarity).;Ubiquitinated by the E3 ligase SYVN1, leading to STXBP5L proteasomal degradation.	Belongs to the WD repeat L(2)GL family.	NA	PE1	3
+NX_Q9Y2L1	Exosome complex exonuclease RRP44	958	109003	6.69	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Nucleus	NA	Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.	NA	Belongs to the RNR ribonuclease family.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;mRNA decay by 3' to 5' exoribonuclease;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	13
+NX_Q9Y2L5	Trafficking protein particle complex subunit 8	1435	160997	6.41	0	Cytoplasm;cis-Golgi network;Cytosol;Nucleus;Cytoskeleton	NA	Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178).	NA	Belongs to the TRS85 family.	RAB GEFs exchange GTP for GDP on RABs	PE1	18
+NX_Q9Y2L6	FERM domain-containing protein 4B	1034	118047	8.79	0	Tight junction;Adherens junction;Cytoskeleton	NA	Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization.	NA	NA	NA	PE1	3
+NX_Q9Y2L8	Zinc finger protein with KRAB and SCAN domains 5	839	96903	7.43	0	Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	7
+NX_Q9Y2L9	Leucine-rich repeat and calponin homology domain-containing protein 1	728	80875	5.59	0	Cytoplasm;Cytosol;Nucleolus;Cytoskeleton	NA	Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration.	NA	NA	NA	PE1	13
+NX_Q9Y2M0	Fanconi-associated nuclease 1	1017	114225	7.1	0	Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	Interstitial nephritis, karyomegalic	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).	Ubiquitinated and degraded during mitotic exit by the APC/C-Cdh1 complex.	Belongs to the FAN1 family.	Fanconi anemia pathway;Fanconi Anemia Pathway	PE1	15
+NX_Q9Y2M2	Protein SSUH2 homolog	353	39845	9.26	0	Cytoplasm;Nucleus	NA	Plays a role in odontogenesis.	NA	NA	NA	PE1	3
+NX_Q9Y2M5	Kelch-like protein 20	609	67955	6.45	0	trans-Golgi network;Golgi apparatus;Perinuclear region;Cytosol;Axon;Dendrite;Nucleus	NA	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	1
+NX_Q9Y2N7	Hypoxia-inducible factor 3-alpha	669	72433	5.67	0	Cytoplasm;Nucleus speckle;Mitochondrion;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression.;Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.;Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.;Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed:17998805).;Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity).	Ubiquitinated; ubiquitination occurs in a VHL- and oxygen-dependent pathway and subsequently targeted for proteasomal degradation.;In normoxia, hydroxylated on Pro-492 in the oxygen-dependent degradation domain (ODD) by prolyl hydroxylase(s) (PHD). The hydroxylated proline promotes interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation.	NA	Transcriptional regulation of pluripotent stem cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Regulation of gene expression by Hypoxia-inducible Factor;Neddylation	PE1	19
+NX_Q9Y2P0	Zinc finger protein 835	537	59631	8.88	0	Nucleus;Cytoskeleton	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q9Y2P4	Long-chain fatty acid transport protein 6	619	70112	8.75	2	Membrane;Sarcolemma;Nucleus	NA	Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	PPAR signaling pathway;Transport of fatty acids	PE1	5
+NX_Q9Y2P5	Bile acyl-CoA synthetase	690	75385	7.8	2	Endoplasmic reticulum membrane;Microsome;Cell membrane	NA	Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:10749848, PubMed:11980911). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed:10749848, PubMed:11980911). Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed:10479480). In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Exhibits long-chain fatty acids (LCFA) transport activity (PubMed:20530735). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity).	NA	Belongs to the ATP-dependent AMP-binding enzyme family.	Primary bile acid biosynthesis;Metabolic pathways;PPAR signaling pathway;Bile secretion;Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Recycling of bile acids and salts	PE1	19
+NX_Q9Y2P7	Zinc finger protein 256	627	71871	9.12	0	Nucleoplasm;Nucleus	NA	Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9Y2P8	RNA 3'-terminal phosphate cyclase-like protein	373	40843	9.36	0	Nucleoplasm;Nucleolus	NA	Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity).	NA	Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	9
+NX_Q9Y2Q0	Phospholipid-transporting ATPase IA	1164	131369	6.41	10	Golgi apparatus;Chromaffin granule membrane;Cell membrane;Endoplasmic reticulum;Cytoplasmic vesicle;Cytoplasmic granule	NA	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.	NA	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ion transport by P-type ATPases;Neutrophil degranulation	PE1	4
+NX_Q9Y2Q1	Zinc finger protein 257	563	65779	9.23	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE2	19
+NX_Q9Y2Q3	Glutathione S-transferase kappa 1	226	25497	8.51	0	Cytoplasm;Peroxisome;Nucleus	NA	Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).	NA	Belongs to the GST superfamily. Kappa family.	Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Peroxisome;Glutathione conjugation;Peroxisomal protein import	PE1	7
+NX_Q9Y2Q5	Ragulator complex protein LAMTOR2	125	13508	5.3	0	Cytoplasm;Lysosome membrane;Nucleoplasm;Cytoplasmic vesicle;Late endosome membrane	Immunodeficiency due to defect in MAPBP-interacting protein	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.	NA	Belongs to the GAMAD family.	Macroautophagy;MAP2K and MAPK activation;TP53 Regulates Metabolic Genes;Energy dependent regulation of mTOR by LKB1-AMPK;mTOR signalling;mTORC1-mediated signalling;Neutrophil degranulation;Regulation of PTEN gene transcription	PE1	1
+NX_Q9Y2Q9	28S ribosomal protein S28, mitochondrial	187	20843	9.22	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bS1 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	8
+NX_Q9Y2R0	Cytochrome c oxidase assembly factor 3 homolog, mitochondrial	106	11731	9.59	1	Mitochondrion inner membrane;Mitochondrion	NA	Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.	NA	Belongs to the COA3 family.	NA	PE1	17
+NX_Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	807	91705	7.5	0	Cytoplasmic vesicle;Cytoplasm;Nucleoplasm;Cell membrane	Diabetes mellitus, insulin-dependent;Vitiligo;Rheumatoid arthritis;Systemic lupus erythematosus	Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).	Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases.	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.	Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse	PE1	1
+NX_Q9Y2R4	Probable ATP-dependent RNA helicase DDX52	599	67498	9.69	0	Nucleoplasm;Nucleolus	NA	NA	NA	Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	17
+NX_Q9Y2R5	28S ribosomal protein S17, mitochondrial	130	14502	9.87	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uS17 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	7
+NX_Q9Y2R9	28S ribosomal protein S7, mitochondrial	242	28134	10	0	Mitochondrion	Combined oxidative phosphorylation deficiency 34	NA	NA	Belongs to the universal ribosomal protein uS7 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	17
+NX_Q9Y2S2	Lambda-crystallin homolog	319	35419	5.81	0	Golgi apparatus;Cytoplasm;Cell membrane;Nucleolus;Nucleoplasm	NA	NA	NA	Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.	Pentose and glucuronate interconversions;Metabolic pathways;Formation of xylulose-5-phosphate	PE1	13
+NX_Q9Y2S6	Translation machinery-associated protein 7	64	7066	10	0	Nucleoplasm;Nucleolus;Nucleus	NA	NA	NA	Belongs to the TMA7 family.	NA	PE1	3
+NX_Q9Y2S7	Polymerase delta-interacting protein 2	368	42033	8.8	0	Mitochondrion;Nucleus	NA	NA	NA	NA	NA	PE1	17
+NX_Q9Y2T1	Axin-2	843	93558	7.82	0	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	Oligodontia-colorectal cancer syndrome;Colorectal cancer	Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.	ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.;Probably phosphorylated by GSK3B and dephosphorylated by PP2A.;Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.	NA	Wnt signaling pathway;Pathways in cancer;Colorectal cancer;Endometrial cancer;Basal cell carcinoma;Degradation of AXIN;TCF dependent signaling in response to WNT;Binding of TCF/LEF:CTNNB1 to target gene promoters;Ub-specific processing proteases	PE1	17
+NX_Q9Y2T2	AP-3 complex subunit mu-1	418	46939	6.47	0	Golgi apparatus;Cytoplasmic vesicle membrane	NA	Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.	NA	Belongs to the adaptor complexes medium subunit family.	Lysosome;Association of TriC/CCT with target proteins during biosynthesis	PE1	10
+NX_Q9Y2T3	Guanine deaminase	454	51003	5.44	0	Nucleoplasm	NA	Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.	NA	Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.;Purine metabolism;Metabolic pathways;Purine catabolism	PE1	9
+NX_Q9Y2T4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform	447	51515	5.92	0	NA	NA	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	NA	Belongs to the phosphatase 2A regulatory subunit B family.	mRNA surveillance pathway;Tight junction;Dopaminergic synapse;Chagas disease (American trypanosomiasis);Hepatitis C	PE1	4
+NX_Q9Y2T5	G-protein coupled receptor 52	361	41354	8.45	7	Cell membrane	NA	Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).	NA	Belongs to the G-protein coupled receptor 1 family.	NA	PE1	1
+NX_Q9Y2T6	G-protein coupled receptor 55	319	36637	8.8	7	Cell membrane	NA	May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Class A/1 (Rhodopsin-like receptors)	PE1	2
+NX_Q9Y2T7	Y-box-binding protein 2	364	38518	10.8	0	Cytoplasm;Nucleus	NA	Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).	Phosphorylated during oocyte maturation and dephosphorylated following egg activation. Phosphorylated in vitro by a kinase activity associated with testicular mRNPs. Dephosphorylation leads to a decrease in its affinity to bind RNA in vitro (By similarity).	NA	NA	PE1	17
+NX_Q9Y2U2	Potassium channel subfamily K member 7	307	31947	6.7	4	Membrane;Cell membrane	NA	Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.	NA	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK);Phase 4 - resting membrane potential	PE2	11
+NX_Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	619	69741	8.04	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.	Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation.;Autophosphorylated.;MAP3K2 is phosphorylated by WNK1	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway;Gap junction;GnRH signaling pathway	PE1	2
+NX_Q9Y2U8	Inner nuclear membrane protein Man1	911	99997	7.32	2	Nucleus inner membrane;Nucleus membrane	Buschke-Ollendorff syndrome	Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.	NA	NA	Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina;Nuclear Envelope Breakdown	PE1	12
+NX_Q9Y2U9	Kelch domain-containing protein 2	406	46099	6.13	0	Nucleoplasm;Nucleus membrane;Nucleus	NA	Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.	NA	NA	NA	PE1	14
+NX_Q9Y2V0	Protein C15orf41	281	32264	6.15	0	Nucleoplasm;Cytoplasm;Nucleus	Anemia, congenital dyserythropoietic, 1B	Plays a role in erythroid cell differentiation.	NA	NA	NA	PE1	15
+NX_Q9Y2V2	Calcium-regulated heat-stable protein 1	147	15892	8.41	0	Cytoplasm;P-body;Cytoplasmic granule	NA	Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).	Dephosphorylated by calcineurin in a Ca(2+) dependent manner (By similarity). Can be phosphorylated by DYRK2 (in vitro).	NA	NA	PE1	16
+NX_Q9Y2V3	Retinal homeobox protein Rx	346	36676	9.11	0	Nucleus	Microphthalmia, isolated, 3	Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter.	NA	Belongs to the paired homeobox family. Bicoid subfamily.	NA	PE1	18
+NX_Q9Y2V7	Conserved oligomeric Golgi complex subunit 6	657	73279	5.51	0	Golgi apparatus;Nucleus speckle;Golgi apparatus membrane	Shaheen syndrome;Congenital disorder of glycosylation 2L	Required for normal Golgi function.	NA	Belongs to the COG6 family.	Intra-Golgi traffic;COPI-mediated anterograde transport;Retrograde transport at the Trans-Golgi-Network	PE1	13
+NX_Q9Y2W1	Thyroid hormone receptor-associated protein 3	955	108666	10.16	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).	ADP-ribosylation during genotoxic stress promotes accumulation in nuclear speckles.;THRAP3 is phosphorylated by MAPK3	Belongs to the BCLAF1/THRAP3 family.	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	1
+NX_Q9Y2W2	WW domain-binding protein 11	641	69998	8.28	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.	NA	NA	Spliceosome;mRNA Splicing - Major Pathway	PE1	12
+NX_Q9Y2W3	Proton-associated sugar transporter A	782	84541	8.01	12	Membrane	Intellectual developmental disorder with neuropsychiatric features	Proton-associated glucose transporter in the brain.	NA	Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.	NA	PE1	1
+NX_Q9Y2W6	Tudor and KH domain-containing protein	561	62046	4.91	0	Cytoplasm;Cytosol;Centrosome;Mitochondrion	NA	Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	Belongs to the Tdrkh family.	PIWI-interacting RNA (piRNA) biogenesis	PE1	1
+NX_Q9Y2W7	Calsenilin	256	29231	5.23	0	Golgi apparatus;Cytoplasm;Cell membrane;Endoplasmic reticulum;Nucleus	NA	May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation.;Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).;Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.	Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity).;Proteolytically cleaved by caspase-3.;Phosphorylation at Ser-63 inhibits cleavage by CASP3.;KCNIP3 is phosphorylated by GRK6 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the recoverin family.	Phase 1 - inactivation of fast Na+ channels	PE1	2
+NX_Q9Y2X0	Mediator of RNA polymerase II transcription subunit 16	877	96793	7.12	0	Nucleus;Nucleolus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 16 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	19
+NX_Q9Y2X3	Nucleolar protein 58	529	59578	9.03	0	Nucleoplasm;Nucleolus	NA	Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs.	Sumoylation is essential for high-affinity binding to snoRNAs.	Belongs to the NOP5/NOP56 family.	Ribosome biogenesis in eukaryotes;SUMOylation of RNA binding proteins;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	2
+NX_Q9Y2X7	ARF GTPase-activating protein GIT1	761	84341	6.33	0	Cytoplasm;Cytosol;Mitochondrion;Focal adhesion	NA	GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13 (By similarity).	Phosphorylated on tyrosine residues by PTK2/FAK1 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase (By similarity).	NA	Endocytosis;Regulation of actin cytoskeleton;Epithelial cell signaling in Helicobacter pylori infection;Ephrin signaling;Activation of RAC1 downstream of NMDARs	PE1	17
+NX_Q9Y2X8	Ubiquitin-conjugating enzyme E2 D4	147	16649	6.88	0	NA	NA	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.	NA	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	7
+NX_Q9Y2X9	Zinc finger protein 281	895	96915	8.71	0	Nucleoplasm;Nucleus	NA	Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	1
+NX_Q9Y2Y0	ADP-ribosylation factor-like protein 2-binding protein	163	18822	4.23	0	Cytoplasm;Mitochondrion intermembrane space;Cilium basal body;Centrosome;Spindle;Nucleus	Retinitis pigmentosa 82 with or without situs inversus	Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.	NA	Belongs to the ARL2BP family.	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	PE1	16
+NX_Q9Y2Y1	DNA-directed RNA polymerase III subunit RPC10	108	12336	8.05	0	Nucleoplasm;Cytosol;Nucleolus	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).	NA	Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	16
+NX_Q9Y2Y4	Zinc finger and BTB domain-containing protein 32	487	52963	9.36	0	Nucleus	NA	DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q9Y2Y6	Transmembrane protein 98	226	24611	4.81	1	Extracellular exosome;Endoplasmic reticulum membrane;Cell membrane;Secreted;Nucleoplasm;Endosome	Nanophthalmos 4	Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).	NA	Belongs to the TMEM98 family.	NA	PE1	17
+NX_Q9Y2Y8	Proteoglycan 3	225	25406	4.69	0	Cytoplasmic granule	NA	Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils.	NA	NA	Neutrophil degranulation	PE1	11
+NX_Q9Y2Y9	Krueppel-like factor 13	288	31180	9.63	0	Nucleus	NA	Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.	Phosphorylated.	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	15
+NX_Q9Y2Z0	Protein SGT1 homolog	365	41024	5.07	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.	Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.	Belongs to the SGT1 family.	NOD-like receptor signaling pathway;The NLRP3 inflammasome	PE1	13
+NX_Q9Y2Z2	Protein MTO1 homolog, mitochondrial	717	79964	8.59	0	Nucleoplasm;Cytosol;Mitochondrion	Combined oxidative phosphorylation deficiency 10	Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.	NA	Belongs to the MnmG family.	tRNA modification in the mitochondrion	PE1	6
+NX_Q9Y2Z4	Tyrosine--tRNA ligase, mitochondrial	477	53199	9.07	0	Mitochondrion matrix;Mitochondrion;Nucleus	Myopathy with lactic acidosis and sideroblastic anemia 2	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).	NA	Belongs to the class-I aminoacyl-tRNA synthetase family.	Aminoacyl-tRNA biosynthesis;Mitochondrial tRNA aminoacylation	PE1	12
+NX_Q9Y2Z9	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial	468	50870	6.81	0	Golgi apparatus;Mitochondrion inner membrane;Cell projection	Coenzyme Q10 deficiency, primary, 6	FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6 (By similarity). Is able to perform the deamination reaction at C4 of 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) to produce DHHB when expressed in yeast cells lacking COQ9, even if utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals, where only C5 hydroxylation of HHB has been shown (PubMed:26260787).	NA	Belongs to the UbiH/COQ6 family.	Cofactor biosynthesis; ubiquinone biosynthesis.;Ubiquinone and other terpenoid-quinone biosynthesis;Metabolic pathways;Ubiquinol biosynthesis	PE1	14
+NX_Q9Y303	N-acetylglucosamine-6-phosphate deacetylase	409	43748	6.21	0	Cytosol;Nucleolus	NA	Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.	NA	Belongs to the metallo-dependent hydrolases superfamily. NagA family.	Amino-sugar metabolism; N-acetylneuraminate degradation.;Amino sugar and nucleotide sugar metabolism;Synthesis of UDP-N-acetyl-glucosamine	PE1	16
+NX_Q9Y305	Acyl-coenzyme A thioesterase 9, mitochondrial	439	49902	8.81	0	Nucleoplasm;Cytosol;Mitochondrion;Cell membrane	NA	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.	NA	Belongs to the acyl coenzyme A hydrolase family.	Mitochondrial Fatty Acid Beta-Oxidation	PE1	X
+NX_Q9Y312	Protein AAR2 homolog	384	43472	5.66	0	Cytosol	NA	Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.	NA	Belongs to the AAR2 family.	NA	PE1	20
+NX_Q9Y314	Nitric oxide synthase-interacting protein	301	33172	9.05	0	Nucleoplasm;Cytoplasm;Nucleus	NA	E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).	NA	Belongs to the NOSIP family.	NOSIP mediated eNOS trafficking	PE1	19
+NX_Q9Y315	Deoxyribose-phosphate aldolase	318	35231	9.08	0	Nucleoplasm;Cytoplasm;Cytoplasmic granule;Nucleus	NA	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.	NA	Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.;Pentose phosphate pathway;Pentose phosphate pathway;Neutrophil degranulation	PE1	12
+NX_Q9Y316	Protein MEMO1	297	33733	6.66	0	Cytoplasmic vesicle	NA	May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.	NA	Belongs to the MEMO1 family.	ERBB2 Regulates Cell Motility	PE1	2
+NX_Q9Y320	Thioredoxin-related transmembrane protein 2	296	34038	8.9	1	Membrane;Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	11
+NX_Q9Y324	rRNA-processing protein FCF1 homolog	198	23370	9.74	0	Nucleoplasm;Nucleolus	NA	Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.	NA	Belongs to the UTP23/FCF1 family. FCF1 subfamily.	Ribosome biogenesis in eukaryotes;Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	14
+NX_Q9Y328	Neuronal vesicle trafficking-associated protein 2	171	19085	9.42	1	Golgi apparatus;Endosome membrane;trans-Golgi network membrane;Golgi stack membrane;Cytoplasmic vesicle membrane;Membrane;Lysosome lumen;Early endosome membrane;Dendrite;Multivesicular body membrane;Late endosome membrane	NA	NA	NA	Belongs to the NSG family.	NA	PE1	5
+NX_Q9Y330	Zinc finger and BTB domain-containing protein 12	459	49148	7.26	0	Nucleoplasm;Nucleus	NA	May be involved in transcriptional regulation.	NA	NA	NA	PE1	6
+NX_Q9Y333	U6 snRNA-associated Sm-like protein LSm2	95	10835	6.05	0	Nucleoplasm;Nucleus	NA	Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).	NA	Belongs to the snRNP Sm proteins family.	RNA degradation;Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA decay by 5' to 3' exoribonuclease	PE1	6
+NX_Q9Y334	von Willebrand factor A domain-containing protein 7	891	96060	5.74	0	Cytosol;Secreted;Cell membrane	NA	NA	NA	NA	NA	PE1	6
+NX_Q9Y336	Sialic acid-binding Ig-like lectin 9	463	50082	6.86	1	Membrane	NA	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.	NA	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Neutrophil degranulation	PE1	19
+NX_Q9Y337	Kallikrein-5	293	32020	8.64	0	Secreted	NA	May be involved in desquamation.	NA	Belongs to the peptidase S1 family. Kallikrein subfamily.	Formation of the cornified envelope	PE1	19
+NX_Q9Y342	Plasmolipin	182	19987	9.43	4	Membrane	NA	Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity).	NA	Belongs to the MAL family.	NA	PE1	16
+NX_Q9Y343	Sorting nexin-24	169	19818	6.71	0	Cytoplasmic vesicle membrane;Cytoplasmic vesicle	NA	May be involved in several stages of intracellular trafficking.	NA	Belongs to the sorting nexin family.	NA	PE1	5
+NX_Q9Y345	Sodium- and chloride-dependent glycine transporter 2	797	87434	7.68	12	Cell membrane	Hyperekplexia 3	Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses.	NA	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A5 subfamily.	Na+/Cl- dependent neurotransmitter transporters;Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	PE1	11
+NX_Q9Y365	START domain-containing protein 10	291	33049	6.67	0	Membrane;Cytoplasm;Cytosol;Flagellum	NA	May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.	Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association.	NA	Synthesis of PC	PE1	11
+NX_Q9Y366	Intraflagellar transport protein 52 homolog	437	49706	5.14	0	Cytosol;Cilium	Short-rib thoracic dysplasia 16 with or without polydactyly	Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia (PubMed:27466190). Required for the anterograde transport of IFT88 (PubMed:27466190).	NA	NA	Intraflagellar transport;Hedgehog 'off' state	PE1	20
+NX_Q9Y371	Endophilin-B1	365	40796	5.78	0	Mitochondrion outer membrane;Cytoplasm;Autophagosome membrane;Golgi apparatus membrane;Cytosol;Midbody	NA	Acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity).;May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588).;Acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).	Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization.	Belongs to the endophilin family.	Endocytosis	PE1	1
+NX_Q9Y375	Complex I intermediate-associated protein 30, mitochondrial	327	37764	7.11	0	Mitochondrion matrix;Mitochondrion;Cytosol	Mitochondrial complex I deficiency, nuclear type 11	Chaperone protein involved in early stages of the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).	NA	Belongs to the CIA30 family.	Complex I biogenesis	PE1	15
+NX_Q9Y376	Calcium-binding protein 39	341	39869	6.43	0	Cytoplasm;Cytosol;Nucleolus	NA	Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.	NA	Belongs to the Mo25 family.	mTOR signaling pathway;Energy dependent regulation of mTOR by LKB1-AMPK;Neutrophil degranulation	PE1	2
+NX_Q9Y383	Putative RNA-binding protein Luc7-like 2	392	46514	10.02	0	Nucleoplasm;Nucleus speckle;Nucleus	NA	May bind to RNA via its Arg/Ser-rich domain.	NA	Belongs to the Luc7 family.	NA	PE1	7
+NX_Q9Y385	Ubiquitin-conjugating enzyme E2 J1	318	35199	6.26	1	Endoplasmic reticulum membrane	NA	Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).	NA	Belongs to the ubiquitin-conjugating enzyme family.	Protein modification; protein ubiquitination.;Ubiquitin mediated proteolysis;Protein processing in endoplasmic reticulum;Parkinson's disease;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	6
+NX_Q9Y388	RNA-binding motif protein, X-linked 2	322	37336	9.84	0	Nucleolus;Nucleus membrane;Nucleus	NA	Involved in pre-mRNA splicing as component of the activated spliceosome.	NA	Belongs to the IST3 family.	NA	PE1	X
+NX_Q9Y394	Dehydrogenase/reductase SDR family member 7	339	38299	8.59	0	Nucleoplasm;Mitochondrion	NA	NA	NA	Belongs to the short-chain dehydrogenases/reductases (SDR) family.	NA	PE1	14
+NX_Q9Y397	Palmitoyltransferase ZDHHC9	364	40916	8.12	4	Golgi apparatus;Endoplasmic reticulum membrane;Endoplasmic reticulum;Golgi apparatus membrane;Cytosol	Mental retardation, X-linked, syndromic, ZDHHC9-related	The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.	NA	Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.	NA	PE1	X
+NX_Q9Y399	28S ribosomal protein S2, mitochondrial	296	33249	9.37	0	Mitochondrion	Combined oxidative phosphorylation deficiency 36	Required for mitoribosome formation and stability, and mitochondrial translation.	NA	Belongs to the universal ribosomal protein uS2 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	9
+NX_Q9Y3A0	Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial	265	29657	9.29	0	Mitochondrion inner membrane;Mitochondrion	Coenzyme Q10 deficiency, primary, 7	Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.	NA	Belongs to the COQ4 family.	Cofactor biosynthesis; ubiquinone biosynthesis.	PE1	9
+NX_Q9Y3A2	Probable U3 small nucleolar RNA-associated protein 11	253	30447	10.16	0	Nucleoplasm;Nucleolus	NA	Involved in nucleolar processing of pre-18S ribosomal RNA.	NA	Belongs to the UTP11 family.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	1
+NX_Q9Y3A3	MOB-like protein phocein	225	26032	5.5	0	Golgi stack membrane;Golgi apparatus;Membrane;Perinuclear region	NA	May play a role in membrane trafficking, specifically in membrane budding reactions.	Phosphorylated on serine residues.	Belongs to the MOB1/phocein family.	NA	PE1	2
+NX_Q9Y3A4	Ribosomal RNA-processing protein 7 homolog A	280	32334	9.61	0	NA	NA	NA	NA	Belongs to the RRP7 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	22
+NX_Q9Y3A5	Ribosome maturation protein SBDS	250	28764	8.91	0	Cytoplasm;Nucleolus;Nucleoplasm;Cytosol;Spindle	Shwachman-Diamond syndrome 1	Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.	NA	Belongs to the SDO1/SBDS family.	Ribosome biogenesis in eukaryotes	PE1	7
+NX_Q9Y3A6	Transmembrane emp24 domain-containing protein 5	229	26005	4.71	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;cis-Golgi network membrane;Endoplasmic reticulum membrane	NA	Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.	NA	Belongs to the EMP24/GP25L family.	WNT ligand biogenesis and trafficking	PE1	1
+NX_Q9Y3B1	PRELI domain containing protein 3B	194	21495	6.24	0	Nucleoplasm	NA	NA	NA	Belongs to the slowmo family.	NA	PE1	20
+NX_Q9Y3B2	Exosome complex component CSL4	195	21452	8.51	0	Nucleoplasm;Cytoplasm;Nucleolus;Nucleus	NA	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.	NA	Belongs to the CSL4 family.	RNA degradation;ATF4 activates genes in response to endoplasmic reticulum stress;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;mRNA decay by 3' to 5' exoribonuclease;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	10
+NX_Q9Y3B3	Transmembrane emp24 domain-containing protein 7	224	25172	6.43	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane;cis-Golgi network membrane;COPI-coated vesicle membrane;COPII-coated vesicle membrane	NA	Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.	N-linked glycosylated in complex form containing terminal sialic acid.	Belongs to the EMP24/GP25L family.	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	5
+NX_Q9Y3B4	Splicing factor 3B subunit 6	125	14585	9.41	0	Nucleoplasm;Nucleus	NA	Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PubMed:12234937). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (PubMed:16432215). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (PubMed:16432215).	NA	Belongs to the SF3B6 family.	Spliceosome;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway	PE1	2
+NX_Q9Y3B6	ER membrane protein complex subunit 9	208	23061	5.53	0	Golgi apparatus;Cytoplasm	NA	NA	NA	Belongs to the EMC8/EMC9 family.	NA	PE1	14
+NX_Q9Y3B7	39S ribosomal protein L11, mitochondrial	192	20683	9.91	0	Mitochondrion	NA	NA	NA	Belongs to the universal ribosomal protein uL11 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	11
+NX_Q9Y3B8	Oligoribonuclease, mitochondrial	237	26833	6.4	0	Cytoplasm;Mitochondrion;Mitochondrion matrix;Mitochondrion intermembrane space;Focal adhesion;Nucleolus;Nucleus	NA	3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.	NA	Belongs to the oligoribonuclease family.	Ribosome biogenesis in eukaryotes	PE1	11
+NX_Q9Y3B9	RRP15-like protein	282	31484	5.39	0	Cytoplasm;Nucleoplasm;Mitochondrion;Nucleolus	NA	NA	Citrullinated by PADI4.	Belongs to the RRP15 family.	NA	PE1	1
+NX_Q9Y3C0	WASH complex subunit 3	194	21173	4.35	0	Cytoplasmic vesicle;Early endosome	NA	Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093).	NA	Belongs to the CCDC53 family.	NA	PE1	12
+NX_Q9Y3C1	Nucleolar protein 16	178	21188	9.94	0	Nucleolus	NA	NA	NA	Belongs to the NOP16 family.	NA	PE1	5
+NX_Q9Y3C4	EKC/KEOPS complex subunit TPRKB	175	19661	6.31	0	Cytosol;Nucleus	Galloway-Mowat syndrome 5	Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828). TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828).	NA	Belongs to the CGI121/TPRKB family.	tRNA modification in the nucleus and cytosol	PE1	2
+NX_Q9Y3C5	RING finger protein 11	154	17444	4.64	0	Recycling endosome;Cytoplasm;Early endosome;Nucleus	NA	Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.	Ubiquitinated in the presence of ITCH, or SMURF2, and UBE2D1, as well as WWP1.;Acylation at both Gly-2 and Cys-4 is required for proper localization to the endosomes.;Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome.	NA	NA	PE1	1
+NX_Q9Y3C6	Peptidyl-prolyl cis-trans isomerase-like 1	166	18237	7.78	0	Nucleolus;Nucleus	NA	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688).	NA	Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.	Spliceosome;mRNA Splicing - Major Pathway	PE1	6
+NX_Q9Y3C7	Mediator of RNA polymerase II transcription subunit 31	131	15805	8.72	0	Nucleoplasm;Nucleus	NA	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	NA	Belongs to the Mediator complex subunit 31 family.	Generic Transcription Pathway;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation	PE1	17
+NX_Q9Y3C8	Ubiquitin-fold modifier-conjugating enzyme 1	167	19458	6.91	0	Cytosol;Nucleus speckle	Neurodevelopmental disorder with spasticity and poor growth	E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.	NA	Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.	NA	PE1	1
+NX_Q9Y3D0	Cytosolic iron-sulfur assembly component 2B	163	17663	5.07	0	Nucleoplasm;Cytosol;Spindle;Nucleus	NA	Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004, PubMed:22678362, PubMed:22678361). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633).	NA	Belongs to the MIP18 family.	Cytosolic iron-sulfur cluster assembly	PE1	16
+NX_Q9Y3D2	Methionine-R-sulfoxide reductase B2, mitochondrial	182	19536	8.95	0	Mitochondrion	NA	Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.	NA	Belongs to the MsrB Met sulfoxide reductase family.	Protein repair	PE1	10
+NX_Q9Y3D3	28S ribosomal protein S16, mitochondrial	137	15345	9.59	0	Cytosol;Mitochondrion	Combined oxidative phosphorylation deficiency 2	NA	NA	Belongs to the bacterial ribosomal protein bS16 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	10
+NX_Q9Y3D5	28S ribosomal protein S18c, mitochondrial	142	15850	9.63	0	Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bS18 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	4
+NX_Q9Y3D6	Mitochondrial fission 1 protein	152	16938	8.84	1	Mitochondrion outer membrane;Peroxisome membrane;Mitochondrion	NA	Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.	Ubiquitinated by MARCH5.	Belongs to the FIS1 family.	Class I peroxisomal membrane protein import	PE1	7
+NX_Q9Y3D7	Mitochondrial import inner membrane translocase subunit TIM16	125	13825	9.69	0	Mitochondrion inner membrane	Spondylometaphyseal dysplasia, Megarbane-Dagher-Melike type	Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.	NA	Belongs to the TIM16/PAM16 family.	Mitochondrial protein import	PE1	16
+NX_Q9Y3D8	Adenylate kinase isoenzyme 6	172	20061	4.48	0	Cajal body;Nucleus speckle;Nucleoplasm;Centrosome;Cytosol	NA	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.	NA	Belongs to the adenylate kinase family. AK6 subfamily.	Ribosome biogenesis in eukaryotes;Basal transcription factors;Interconversion of nucleotide di- and triphosphates	PE1	5
+NX_Q9Y3D9	28S ribosomal protein S23, mitochondrial	190	21771	8.94	0	Mitochondrion;Nucleus membrane	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mS23 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	17
+NX_Q9Y3E0	Vesicle transport protein GOT1B	138	15426	10.36	4	Cytoplasmic vesicle;Nucleoplasm;Endoplasmic reticulum;Golgi apparatus membrane	NA	May be involved in fusion of ER-derived transport vesicles with the Golgi complex.	NA	Belongs to the GOT1 family.	NA	PE1	12
+NX_Q9Y3E1	Hepatoma-derived growth factor-related protein 3	203	22620	7.7	0	Nucleoplasm;Nucleus	NA	Enhances DNA synthesis and may play a role in cell proliferation.	NA	Belongs to the HDGF family.	NA	PE1	15
+NX_Q9Y3E2	BolA-like protein 1	137	14289	7.82	0	Mitochondrion	NA	Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225).	NA	Belongs to the BolA/IbaG family.	NA	PE1	1
+NX_Q9Y3E5	Peptidyl-tRNA hydrolase 2, mitochondrial	179	19194	8.95	0	Mitochondrion	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.;Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.	Belongs to the PTH2 family.	Ub-specific processing proteases	PE1	17
+NX_Q9Y3E7	Charged multivesicular body protein 3	222	25073	5.1	0	Membrane;Endosome;Late endosome membrane;Cytosol	NA	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor.;Prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.	NA	Belongs to the SNF7 family.	Endocytosis;Macroautophagy;Budding and maturation of HIV virion;Endosomal Sorting Complex Required For Transport (ESCRT);Microautophagy	PE1	2
+NX_Q9Y3F1	Putative TAP2-associated 6.5 kDa polypeptide	56	6535	4.49	0	NA	NA	May be associated with TAP2 isoform activity.	NA	NA	NA	PE5	6
+NX_Q9Y3F4	Serine-threonine kinase receptor-associated protein	350	38438	4.98	0	Cytoplasm;Cytosol;Nucleus	NA	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.	NA	Belongs to the WD repeat STRAP family.	RNA transport;Downregulation of TGF-beta receptor signaling	PE1	12
+NX_Q9Y3I0	tRNA-splicing ligase RtcB homolog	505	55210	6.77	0	Cytoplasm;Nucleoplasm;Cytoplasmic vesicle;Cytosol;Nucleus	NA	Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.	NA	Belongs to the RtcB family.	tRNA processing in the nucleus	PE1	22
+NX_Q9Y3I1	F-box only protein 7	522	58503	6.11	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	Parkinson disease 15	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	22
+NX_Q9Y3L3	SH3 domain-binding protein 1	701	75713	6.33	0	Adherens junction;Cell projection;Tight junction;Phagocytic cup;Cytosol;Nucleus	NA	GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563).	NA	NA	NA	PE1	22
+NX_Q9Y3L5	Ras-related protein Rap-2c	183	20745	4.87	0	Cytoplasm;Recycling endosome membrane	NA	Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.	Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.	Belongs to the small GTPase superfamily. Ras family.	Neutrophil degranulation	PE1	X
+NX_Q9Y3M2	Protein chibby homolog 1	126	14470	9.09	0	trans-Golgi network;Golgi apparatus;Nucleus speckle;Centriole;Cilium basal body	NA	Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.	NA	Belongs to the chibby family.	Deactivation of the beta-catenin transactivating complex	PE1	22
+NX_Q9Y3M8	StAR-related lipid transfer protein 13	1113	124967	6.57	0	Mitochondrion membrane;Cytoplasm;Membrane;Lipid droplet	NA	GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.	NA	NA	Rho GTPase cycle	PE1	13
+NX_Q9Y3M9	Zinc finger protein 337	751	86875	9.74	0	Nucleus speckle;Nucleus;Cell membrane	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	20
+NX_Q9Y3N9	Olfactory receptor 2W1	320	36101	9.24	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	6
+NX_Q9Y3P4	Rhomboid domain-containing protein 3	386	40484	6.1	5	Membrane;Cytoskeleton	NA	NA	NA	NA	NA	PE1	22
+NX_Q9Y3P8	Signaling threshold-regulating transmembrane adapter 1	196	21126	5.91	1	Cell membrane	NA	Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.	Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK.	NA	NA	PE1	9
+NX_Q9Y3P9	Rab GTPase-activating protein 1	1069	121737	5.15	0	Cytosol;Centrosome	NA	May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.	NA	NA	TBC/RABGAPs	PE1	9
+NX_Q9Y3Q0	N-acetylated-alpha-linked acidic dipeptidase 2	740	83592	8.56	1	Nucleoplasm;Cell membrane	NA	Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate.	NA	Belongs to the peptidase M28 family. M28B subfamily.	Aspartate and asparagine metabolism	PE1	11
+NX_Q9Y3Q3	Transmembrane emp24 domain-containing protein 3	217	24777	5.4	1	Golgi apparatus;Endoplasmic reticulum-Golgi intermediate compartment membrane;Endoplasmic reticulum membrane;cis-Golgi network membrane;Golgi stack membrane;COPI-coated vesicle membrane	NA	Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network.	NA	Belongs to the EMP24/GP25L family.	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	15
+NX_Q9Y3Q4	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	1203	129042	9.07	6	Cell membrane	Brugada syndrome 8;Sick sinus syndrome 2	Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.	NA	Belongs to the potassium channel HCN family.	HCN channels	PE1	15
+NX_Q9Y3Q7	Disintegrin and metalloproteinase domain-containing protein 18	739	82856	7.16	1	Membrane	NA	Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity).	The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa.	NA	NA	PE1	8
+NX_Q9Y3Q8	TSC22 domain family protein 4	395	41026	6.69	0	Cytosol;Nucleus	NA	Transcriptional repressor.	NA	Belongs to the TSC-22/Dip/Bun family.	NA	PE1	7
+NX_Q9Y3R0	Glutamate receptor-interacting protein 1	1128	122422	6.03	0	Cytoplasm;Endoplasmic reticulum membrane;Postsynaptic cell membrane;Endomembrane system;Perikaryon;Postsynaptic density;Cytoplasmic vesicle;Dendrite	Fraser syndrome 3	May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	NA	NA	Trafficking of GluR2-containing AMPA receptors	PE1	12
+NX_Q9Y3R4	Sialidase-2	380	42254	6.39	0	Cytoplasm	NA	Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.	NA	Belongs to the glycosyl hydrolase 33 family.	Other glycan degradation;Sphingolipid metabolism;Sialic acid metabolism;Glycosphingolipid metabolism	PE1	2
+NX_Q9Y3R5	Protein dopey-2	2298	258230	5.9	0	Nucleoplasm;Mitochondrion;Golgi apparatus membrane	NA	May be involved in protein traffic between late Golgi and early endosomes.	NA	Belongs to the dopey family.	NA	PE1	21
+NX_Q9Y3S1	Serine/threonine-protein kinase WNK2	2297	242676	5.79	0	Cytoplasm;Cytosol;Cell membrane	NA	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.	Autophosphorylated.;Autophosphorylated (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);WNK2 is phosphorylated by WNK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.	Stimuli-sensing channels	PE1	9
+NX_Q9Y3S2	Zinc finger protein 330	320	36201	5.79	0	Nucleolus;Centromere;Nucleus	NA	NA	NA	Belongs to the NOA36 family.	NA	PE1	4
+NX_Q9Y3T6	R3H and coiled-coil domain-containing protein 1	440	49092	5.47	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	8
+NX_Q9Y3T9	Nucleolar complex protein 2 homolog	749	84919	5.46	0	Nucleoplasm;Nucleolus;Nucleus	NA	Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.	NA	Belongs to the NOC2 family.	Regulation of TP53 Activity through Phosphorylation	PE1	1
+NX_Q9Y3U8	60S ribosomal protein L36	105	12254	11.59	0	Cytoplasm;Nucleolus;Endoplasmic reticulum;Cytosol;Nucleus	NA	Component of the large ribosomal subunit.	NA	Belongs to the eukaryotic ribosomal protein eL36 family.	Ribosome;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);L13a-mediated translational silencing of Ceruloplasmin expression;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Eukaryotic Translation Termination;Major pathway of rRNA processing in the nucleolus and cytosol;Selenocysteine synthesis;Regulation of expression of SLITs and ROBOs	PE1	19
+NX_Q9Y3V2	RWD domain-containing protein 3	267	30543	5.81	0	Cytoplasm;Nucleus	NA	Promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.;Positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity.;Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1.;Negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia.	NA	NA	SUMO is transferred from E1 to E2 (UBE2I, UBC9)	PE1	1
+NX_Q9Y3X0	Coiled-coil domain-containing protein 9	531	59703	5.32	0	Cytoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	19
+NX_Q9Y3Y2	Chromatin target of PRMT1 protein	248	26397	12.24	0	Nucleoplasm;Nucleolus;Nucleus speckle;Nucleus	NA	Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).;Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939).	Asymmetrically methylated by PRMT1 (PubMed:25284789). Symmetrically methylated by PRMT5 (By similarity).	NA	Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing;RNA Polymerase II Transcription Termination	PE1	1
+NX_Q9Y3Y4	Pygopus homolog 1	419	45116	6.38	0	Nucleoplasm;Cytosol;Nucleus	NA	Involved in signal transduction through the Wnt pathway.	NA	NA	Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex	PE1	15
+NX_Q9Y3Z3	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	626	72201	6.69	0	Nucleoplasm;Cell membrane;Nucleus;Chromosome	Aicardi-Goutieres syndrome 5;Chilblain lupus 2	Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:23602554, PubMed:23601106, PubMed:22056990, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:23602554, PubMed:23601106, PubMed:23364794, PubMed:25038827, PubMed:26101257, PubMed:22056990, PubMed:24336198, PubMed:28229507, PubMed:26294762, PubMed:26431200). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:29610582, PubMed:24217394). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23602554, PubMed:23601106, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity).	Phosphorylation at Thr-592 by CDK1 acts as a switch to control deoxynucleoside triphosphate (dNTPase)-dependent and -independent functions (PubMed:29670289). Phosphorylation at Thr-592 takes place in cycling cells: it reduces the stability of the homotetramer, impairing the dNTPase activity and subsequent ability to restrict infection by viruses (PubMed:23602554, PubMed:23601106, PubMed:26294762, PubMed:26431200). It also inhibits ability to suppress LINE-1 retrotransposon activity (PubMed:29610582). In contrast, phosphorylation at Thr-592 promotes DNA end resection at stalled replication forks in response to DNA damage (PubMed:29670289).;(Microbial infection) Ubiquitinated following interaction with HIV-2 viral protein Vpx; Vpx promotes interaction and with a DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase, leading to proteasomal degradation.	Belongs to the SAMHD1 family.	Interferon alpha/beta signaling;Nucleobase catabolism	PE1	20
+NX_Q9Y421	Protein FAM32A	112	13178	9.99	0	Nucleoplasm;Nucleolus;Nucleus	NA	But not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.	NA	Belongs to the FAM32 family.	NA	PE1	19
+NX_Q9Y426	C2 domain-containing protein 2	696	75533	6.47	1	Membrane;Nucleoplasm	NA	NA	NA	NA	NA	PE1	21
+NX_Q9Y442	Uncharacterized protein C22orf24	160	17735	8.46	1	Membrane	NA	NA	NA	NA	NA	PE2	22
+NX_Q9Y446	Plakophilin-3	797	87082	9.39	0	Nucleoplasm;Cell junction;Desmosome;Nucleus	NA	May play a role in junctional plaques.	NA	Belongs to the beta-catenin family.	Formation of the cornified envelope;Keratinization	PE1	11
+NX_Q9Y448	Small kinetochore-associated protein	316	35438	5.98	0	Cell membrane;Centriolar satellite;Spindle pole;Nucleus;Spindle;Kinetochore	NA	Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).	NA	NA	NA	PE1	15
+NX_Q9Y450	HBS1-like protein	684	75473	6.17	0	Cytosol;Nucleus	NA	NA	NA	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.	mRNA surveillance pathway;Legionellosis;mRNA decay by 3' to 5' exoribonuclease	PE1	6
+NX_Q9Y458	T-box transcription factor TBX22	520	57910	6.92	0	Nucleus	Abruzzo-Erickson syndrome;Cleft palate with or without ankyloglossia, X-linked	Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.	NA	NA	NA	PE1	X
+NX_Q9Y462	Zinc finger protein 711	761	86245	6.4	0	Nucleoplasm;Nucleus	Mental retardation, X-linked 97	Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	X
+NX_Q9Y463	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	629	69198	9.25	0	Nucleoplasm;Nucleus	Abdominal obesity-metabolic syndrome 3	Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).	Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.;DYRK1B is phosphorylated by MAPK14 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);DYRK1B is phosphorylated by MAPK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.	NA	PE1	19
+NX_Q9Y466	Nuclear receptor subfamily 2 group E member 1	385	42589	9.18	0	Nucleus	NA	Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells.	NA	Belongs to the nuclear hormone receptor family. NR2 subfamily.	Nuclear Receptor transcription pathway;Regulation of PTEN gene transcription	PE1	6
+NX_Q9Y467	Sal-like protein 2	1007	105309	5.89	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	Coloboma, ocular, autosomal recessive	Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure.	NA	Belongs to the sal C2H2-type zinc-finger protein family.	NA	PE1	14
+NX_Q9Y468	Lethal(3)malignant brain tumor-like protein 1	840	92297	5.65	0	Nucleoplasm;Nucleus	NA	Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.	Ubiquitinated in a VCP/p97-dependent way following DNA damage, leading to its removal from DNA damage sites, promoting accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited to DNA damage sites.	NA	Regulation of TP53 Activity through Methylation	PE1	20
+NX_Q9Y471	Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase	501	58380	5.96	0	Cytoplasm	NA	Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells in vertebrates (PubMed:9624188). However, it may play a role in Wnt signaling (PubMed:19890979).	NA	Belongs to the CMP-Neu5Ac hydroxylase family.	NA	PE1	6
+NX_Q9Y473	Zinc finger protein 175	711	81609	8.98	0	Cytoplasm;Nucleoplasm;Cytosol;Nucleus;Cytoskeleton	NA	Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	19
+NX_Q9Y478	5'-AMP-activated protein kinase subunit beta-1	270	30382	5.94	0	Nucleoplasm;Cytosol	NA	Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).	Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.	Belongs to the 5'-AMP-activated protein kinase beta subunit family.	Insulin signaling pathway;Adipocytokine signaling pathway;Hypertrophic cardiomyopathy (HCM);Macroautophagy;Translocation of SLC2A4 (GLUT4) to the plasma membrane;TP53 Regulates Metabolic Genes;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Energy dependent regulation of mTOR by LKB1-AMPK;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs;Lipophagy	PE1	12
+NX_Q9Y483	Metal-response element-binding transcription factor 2	593	67090	9	0	Nucleoplasm;Nucleus	NA	Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).	NA	Belongs to the Polycomblike family.	PRC2 methylates histones and DNA	PE1	1
+NX_Q9Y484	WD repeat domain phosphoinositide-interacting protein 4	360	39868	6.74	0	Cytoplasm;Preautophagosomal structure;Nucleolus	Neurodegeneration with brain iron accumulation 5	Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066).	NA	Belongs to the WD repeat SVP1 family.	Macroautophagy	PE1	X
+NX_Q9Y485	DmX-like protein 1	3027	337839	5.91	0	Cytosol;Nucleolus	NA	NA	NA	NA	NA	PE1	5
+NX_Q9Y487	V-type proton ATPase 116 kDa subunit a isoform 2	856	98082	6.18	8	Cytosol;Endosome membrane;Cell membrane	Wrinkly skin syndrome;Cutis laxa, autosomal recessive, 2A	Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).	NA	Belongs to the V-ATPase 116 kDa subunit family.	Oxidative phosphorylation;Metabolic pathways;Lysosome;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Tuberculosis;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport	PE1	12
+NX_Q9Y490	Talin-1	2541	269767	5.77	0	Cell membrane;Centriolar satellite;Focal adhesion;Cell surface;Ruffle membrane;Cytosol;Cytoskeleton	NA	Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).	NA	NA	Focal adhesion;HTLV-I infection;XBP1(S) activates chaperone genes;MAP2K and MAPK activation;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Platelet degranulation;Smooth Muscle Contraction;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins;p130Cas linkage to MAPK signaling for integrins;Signaling by BRAF and RAF fusions;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF	PE1	9
+NX_Q9Y493	Zonadhesin	2812	305630	5.76	1	Cell membrane	NA	Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.	NA	NA	NA	PE1	7
+NX_Q9Y496	Kinesin-like protein KIF3A	699	80041	6.16	0	Centriole;Cilium;Nucleoplasm;Cytosol;Cytoskeleton	NA	Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.	MHC class II antigen presentation;Intraflagellar transport;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Kinesins;Hedgehog 'off' state;Activation of SMO;COPI-dependent Golgi-to-ER retrograde traffic	PE1	5
+NX_Q9Y4A0	Jerky protein homolog-like	524	59912	8.26	0	Nucleoplasm;Nucleus;Cytoskeleton	NA	NA	NA	Belongs to the tigger transposable element derived protein family.	NA	PE1	11
+NX_Q9Y4A5	Transformation/transcription domain-associated protein	3859	437600	8.49	0	Golgi apparatus;Nucleoplasm;Nucleus	NA	Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.	NA	Belongs to the PI3/PI4-kinase family. TRA1 subfamily.	HTLV-I infection;HATs acetylate histones;Formation of the beta-catenin:TCF transactivating complex;Ub-specific processing proteases	PE1	7
+NX_Q9Y4A8	Nuclear factor erythroid 2-related factor 3	694	76154	5.21	0	Cytoplasmic vesicle;Nucleoplasm;Nucleus	NA	Activates erythroid-specific, globin gene expression.	NA	Belongs to the bZIP family. CNC subfamily.	NA	PE1	7
+NX_Q9Y4A9	Olfactory receptor 10H1	318	35254	9.07	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	19
+NX_Q9Y4B4	Helicase ARIP4	1467	162769	5.75	0	Nucleoplasm;Cytosol;Nucleus	NA	DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity).	Sumoylated.	Belongs to the SNF2/RAD54 helicase family.	NA	PE1	3
+NX_Q9Y4B5	Microtubule cross-linking factor 1	1905	209526	6.03	0	Lateral cell membrane;Spindle pole;Apical cell membrane;Midbody;Cytoskeleton	NA	Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells.	NA	Belongs to the SOGA family.	NA	PE1	18
+NX_Q9Y4B6	DDB1- and CUL4-associated factor 1	1507	169007	4.92	0	Nucleoplasm;Nucleus;Cytoplasm;Nucleolus	NA	(Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT.;(Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.;Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714).	DCAF1 is phosphorylated by ATM;DCAF1 is phosphorylated by ATR	Belongs to the VPRBP/DCAF1 family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	3
+NX_Q9Y4C0	Neurexin-3	1643	180599	5.33	1	Membrane	NA	Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.	NA	Belongs to the neurexin family.	Cell adhesion molecules (CAMs);Neurexins and neuroligins	PE1	14
+NX_Q9Y4C1	Lysine-specific demethylase 3A	1321	147341	8.4	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.	NA	Belongs to the JHDM2 histone demethylase family.	HDMs demethylate histones	PE1	2
+NX_Q9Y4C2	TRPM8 channel-associated factor 1	921	102126	6.12	0	Cell membrane	NA	Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.	NA	Belongs to the TCAF family.	NA	PE1	7
+NX_Q9Y4C4	Malignant fibrous histiocytoma-amplified sequence 1	1052	116950	8.02	0	Nucleoplasm;Cytoplasm;Cytosol	NA	Probable GTP-binding protein (PubMed:24286120). Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways (PubMed:26599367, PubMed:28471450, PubMed:28609714). Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (PubMed:28609714). Both inhibits and activates the TLR2-dependent signaling pathway (PubMed:26599367). Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway (PubMed:29168081). Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway (PubMed:23327923).	Ubiquitinated. Ubiquitination by PJA2 does not lead MFHAS1 to proteasomal degradation but positively regulates its function in polarization of macrophages.	NA	NA	PE1	8
+NX_Q9Y4C5	Carbohydrate sulfotransferase 2	530	57857	10	1	Golgi apparatus;Nucleoplasm;Cytosol;trans-Golgi network membrane	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.	Glycosylation at Asn-475 is required for catalytic activity.	Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.	Glycosaminoglycan biosynthesis - keratan sulfate;Keratan sulfate biosynthesis	PE1	3
+NX_Q9Y4C8	Probable RNA-binding protein 19	960	107332	6.13	0	Cytoplasm;Nucleoplasm;Nucleolus;Chromosome	NA	Plays a role in embryo pre-implantation development.	NA	Belongs to the RRM MRD1 family.	NA	PE1	12
+NX_Q9Y4D1	Disheveled-associated activator of morphogenesis 1	1078	123473	6.81	0	Cytoplasm;Cytosol;Cilium basal body;Cell membrane	NA	Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity).	NA	Belongs to the formin homology family.	Wnt signaling pathway;RHO GTPases Activate Formins;PCP/CE pathway	PE1	14
+NX_Q9Y4D2	Sn1-specific diacylglycerol lipase alpha	1042	114952	5.95	4	Cell membrane	Spinocerebellar ataxia 20	Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Arachidonate production from DAG	PE1	11
+NX_Q9Y4D7	Plexin-D1	1925	212007	6.8	1	Lamellipodium membrane;Cell membrane	NA	Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.	NA	Belongs to the plexin family.	Other semaphorin interactions;NOTCH3 Intracellular Domain Regulates Transcription	PE1	3
+NX_Q9Y4D8	Probable E3 ubiquitin-protein ligase HECTD4	3996	439344	5.82	1	Membrane;Cytoplasmic vesicle;Nucleoplasm	NA	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	NA	NA	Protein modification; protein ubiquitination.	PE1	12
+NX_Q9Y4E1	WASH complex subunit 2C	1320	144911	4.66	0	Early endosome membrane;Cell membrane	NA	(Microbial infection) Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells.;Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission (PubMed:19922874, PubMed:20498093, PubMed:22513087, PubMed:23331060). Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35 (PubMed:24980502). Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L (PubMed:25355947, PubMed:28892079).	NA	Belongs to the FAM21 family.	NA	PE1	10
+NX_Q9Y4E5	E3 SUMO-protein ligase ZNF451	1061	121484	6.3	0	Nucleoplasm;Nucleus;PML body	NA	E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).	Sumoylated. Predominantly sumoylated on the N-terminal region that is important for interaction with SUMO1 and SUMO2 (PubMed:18656483, PubMed:26524493, PubMed:26524494). Sumoylation is important for localization in nuclear granules; desumoylation leads to diffuse nucleoplasmic location (PubMed:18656483). Autosumoylated (in vitro) (PubMed:26524493, PubMed:26524494). Sumoylation enhances E3 SUMO-protein ligase activity (PubMed:26524494).	Belongs to the krueppel C2H2-type zinc-finger protein family.	Protein modification; protein sumoylation.	PE1	6
+NX_Q9Y4E6	WD repeat-containing protein 7	1490	163810	6.47	0	Nucleoplasm;Cytosol	NA	NA	NA	NA	NA	PE1	18
+NX_Q9Y4E8	Ubiquitin carboxyl-terminal hydrolase 15	981	112419	5.06	0	Cytoplasm;Cytosol;Mitochondrion;Nucleus	NA	(Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.;Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:21947082, PubMed:22344298, PubMed:24852371, PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102).	Ubiquitinated, leading to degradation by the proteasome.;Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome.	Belongs to the peptidase C19 family.	Downregulation of TGF-beta receptor signaling;UCH proteinases;Ub-specific processing proteases	PE1	12
+NX_Q9Y4F1	FERM, ARHGEF and pleckstrin domain-containing protein 1	1045	118633	8.33	0	Dendritic spine;Synaptosome;Cell membrane;Filopodium;Synapse;Cytosol;Dendrite	NA	Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).	NA	NA	NA	PE1	13
+NX_Q9Y4F3	Meiosis regulator and mRNA stability factor 1	1742	192859	8.14	0	Golgi apparatus;Peroxisome;Cytoplasmic vesicle	NA	Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity).	NA	NA	NA	PE1	16
+NX_Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	1720	189360	8.73	0	Nucleoplasm;Cilium;Cytoskeleton	NA	Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity).	NA	Belongs to the Crescerin family.	NA	PE1	14
+NX_Q9Y4F5	Centrosomal protein of 170 kDa protein B	1589	171688	6.39	0	Cytosol;Centrosome;Cytoskeleton	NA	Plays a role in microtubule organization.	NA	Belongs to the CEP170 family.	NA	PE1	14
+NX_Q9Y4F9	Rho family-interacting cell polarization regulator 2	1068	118519	5.29	0	Cytoplasm;Stereocilium membrane;Filopodium;Stereocilium;Apical cell membrane;Cytoskeleton	Deafness, autosomal recessive, 104	Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:24687993, PubMed:23241886, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875).;Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504).	Is phosphorylated in T cells (PubMed:27556504). Chemokine-induced phosphorylation of isoform 2 in neutrophils occurs in a PKC- and AKT-dependent manner, resulting in RIPOR2 interaction with YWHAB and stabilization (PubMed:25588844).;Phosphorylated.;Is phosphorylated by PKCA, AKT1 and MAPKAPK1A; in vitro (PubMed:25588844).;Acetylated during myogenic differentiation.	Belongs to the RIPOR family.	NA	PE1	6
+NX_Q9Y4G2	Pleckstrin homology domain-containing family M member 1	1056	117443	6.08	0	Cytoplasm;Endosome membrane;Lysosome membrane;Nucleolus;Lysosome;Cytoplasmic vesicle	Osteopetrosis, autosomal recessive 6;Osteopetrosis, autosomal dominant 3	Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7 (PubMed:25500191).	NA	NA	NA	PE1	17
+NX_Q9Y4G6	Talin-2	2542	271613	5.4	0	Cytoplasm;Cell membrane;Focal adhesion;Synapse;Cytosol;Cytoskeleton	NA	As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).	NA	NA	Focal adhesion;HTLV-I infection	PE1	15
+NX_Q9Y4G8	Rap guanine nucleotide exchange factor 2	1499	167417	6.21	0	Cytoplasm;Cell membrane;Cell junction;Nucleoplasm;Centrosome;Late endosome;Cytoplasmic vesicle;Perinuclear region	Epilepsy, familial adult myoclonic, 7	Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.	Ubiquitinated by NEDD4, leading to proteasomal degradation.;Phosphorylation by PLK2 promotes its activity.;RAPGEF2 is phosphorylated by PLK2 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the RAPGEF2 family.	MAPK signaling pathway;RAF/MAP kinase cascade	PE1	4
+NX_Q9Y4H2	Insulin receptor substrate 2	1338	137334	8.9	0	Cytosol	NA	May mediate the control of various cellular processes by insulin.	IRS2 is phosphorylated by INSRR (Phosphotyrosine:PTM-0255);IRS2 is phosphorylated by JAK2 (Phosphotyrosine:PTM-0255)	NA	Neurotrophin signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;RAF/MAP kinase cascade;PI3K Cascade;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Interleukin-7 signaling;Growth hormone receptor signaling;IRS activation;Signal attenuation;IRS-related events triggered by IGF1R;Signaling by Leptin;SOS-mediated signalling;PI3K/AKT activation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;IRS-mediated signalling;Erythropoietin activates RAS;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Signaling by Erythropoietin;Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5	PE1	13
+NX_Q9Y4H4	G-protein-signaling modulator 3	160	17866	4.95	0	Cytoplasm	NA	Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.	NA	NA	G alpha (i) signalling events	PE1	6
+NX_Q9Y4I1	Unconventional myosin-Va	1855	215405	8.7	0	Centriolar satellite;Focal adhesion	Griscelli syndrome 3;Griscelli syndrome 1;Elejalde syndrome	Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Regulation of actin dynamics for phagocytic cup formation;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing	PE1	15
+NX_Q9Y4I5	Tesmin	508	55025	5.5	0	Cytoplasm;Nucleoplasm;Nucleus	NA	May have a role in spermatogenesis.	NA	Belongs to the lin-54 family.	NA	PE1	11
+NX_Q9Y4J8	Dystrobrevin alpha	743	83901	6.43	0	Cytoplasm;Cell membrane;Cell junction;Nucleoplasm;Synapse;Cytoskeleton	Left ventricular non-compaction 1	May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.	Phosphorylation of DTN-1 on tyrosine kinase substrate domain present in the C-terminus.	Belongs to the dystrophin family. Dystrobrevin subfamily.	NA	PE1	18
+NX_Q9Y4K0	Lysyl oxidase homolog 2	774	86725	5.95	0	Cytoplasm;Chromosome;Endoplasmic reticulum;Nucleoplasm;Basement membrane;Nucleus	NA	Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:27735137). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity). Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3 (PubMed:16096638, PubMed:27735137, PubMed:24414204). During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction (PubMed:28332555). Involved in E-cadherin repression following hypoxia, a hallmark of EMT believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression (PubMed:20026874). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:20306300). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (PubMed:21835952). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity).	N-glycosylated. N-glycosylation on Asn-455 and Asn-644 may be essential for proper folding and secretion; may be composed of a fucosylated carbohydrates attached to a trimannose N-linked glycan core.;The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.	Belongs to the lysyl oxidase family.	Elastic fibre formation;Crosslinking of collagen fibrils	PE1	8
+NX_Q9Y4K1	Beta/gamma crystallin domain-containing protein 1	1723	188676	5.61	0	Nucleoplasm;Cytosol;Cytoskeleton	NA	May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.	NA	Belongs to the beta/gamma-crystallin family.	NA	PE1	6
+NX_Q9Y4K3	TNF receptor-associated factor 6	522	59573	6	0	Cytoplasm;Cell cortex;Mitochondrion;Lipid droplet;Nucleolus;Nucleus	NA	E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.	Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1.;Polyubiquitinated on Lys-124; after cell stimulation with IL-1-beta or TGF-beta. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappaB signaling upon DNA damage (PubMed:25861989).	Belongs to the TNF receptor-associated factor family. A subfamily.	Protein modification; protein ubiquitination.;MAPK signaling pathway;Ubiquitin mediated proteolysis;Endocytosis;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Neurotrophin signaling pathway;Pertussis;Leishmaniasis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Tuberculosis;Hepatitis C;Measles;Herpes simplex infection;Pathways in cancer;Small cell lung cancer;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Downstream TCR signaling;PIP3 activates AKT signaling;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;p75NTR recruits signalling complexes;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 dependent cascade initiated on endosome;MyD88 cascade initiated on plasma membrane;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Regulated proteolysis of p75NTR;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;IRAK2 mediated activation of TAK1 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;NF-kB is activated and signals survival;NRIF signals cell death from the nucleus;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Ub-specific processing proteases;Ovarian tumor domain proteases;TICAM1, RIP1-mediated IKK complex recruitment;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling	PE1	11
+NX_Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	846	95024	7.97	0	Cytoplasm;Cytosol;Cell membrane	NA	May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	NA	PE1	14
+NX_Q9Y4L1	Hypoxia up-regulated protein 1	999	111335	5.16	0	Endoplasmic reticulum lumen	Immunodeficiency 59 and hypoglycemia	Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.	NA	Belongs to the heat shock protein 70 family.	Protein processing in endoplasmic reticulum;XBP1(S) activates chaperone genes;Scavenging by Class F Receptors	PE1	11
+NX_Q9Y4L5	E3 ubiquitin-protein ligase RNF115	304	33703	5.39	0	Cytosol;Mitochondrion;Nucleolus	NA	E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.	RING-type zinc finger-dependent and E2-dependent autoubiquitination.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	1
+NX_Q9Y4M8	Putative uncharacterized protein encoded by LINC00588	146	16018	11.24	0	NA	NA	NA	NA	NA	NA	PE5	8
+NX_Q9Y4P1	Cysteine protease ATG4B	393	44294	4.91	0	Nucleoplasm;Cytoplasm;Cytosol;Nucleus	NA	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.	NA	Belongs to the peptidase C54 family.	Regulation of autophagy;Macroautophagy	PE1	2
+NX_Q9Y4P3	Transducin beta-like protein 2	447	49798	9.52	0	Cytosol	NA	NA	NA	NA	NA	PE1	7
+NX_Q9Y4P8	WD repeat domain phosphoinositide-interacting protein 2	454	49408	6.04	0	Nucleoplasm;Cytoplasm;Cytosol;Preautophagosomal structure membrane	NA	Is also required for autophagic clearance of pathogenic bacteria.;Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy.;Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066).;Binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.	NA	Belongs to the WD repeat SVP1 family.	Macroautophagy	PE1	7
+NX_Q9Y4P9	Sperm flagellar protein 1	236	26987	9.7	0	Flagellum;Cytoplasm;Cilium axoneme;Cytoskeleton	NA	Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity).	NA	NA	NA	PE1	20
+NX_Q9Y4R7	Tubulin monoglycylase TTLL3	772	87414	8.73	0	Cilium axoneme;Cilium;Cytoskeleton	NA	Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.	NA	NA	Carboxyterminal post-translational modifications of tubulin	PE1	3
+NX_Q9Y4R8	Telomere length regulation protein TEL2 homolog	837	91747	5.54	0	Cytoplasm;Membrane;Telomere;Cytosol;Nucleus	You-Hoover-Fong syndrome	Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.	Hydroxylation by PHD3 is required for a proper interaction with ATR, and activation of the ATR/CHK1/p53 pathway following DNA damage.;Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.;Phosphorylated at Ser-485 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2; leading to selective ubiquitination of mTORC1-associated protein.	Belongs to the TEL2 family.	Fanconi anemia pathway	PE1	16
+NX_Q9Y4U1	Methylmalonic aciduria and homocystinuria type C protein	282	31728	7.69	0	Nucleoplasm;Cytosol;Cytoplasm;Cell membrane	Methylmalonic aciduria and homocystinuria, cblC type	Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate (PubMed:19700356, PubMed:21697092, PubMed:22642810). Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin (PubMed:19801555, PubMed:22642810, PubMed:25809485). Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen (PubMed:19801555). Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249).	NA	Belongs to the MMACHC family.	Cofactor biosynthesis; adenosylcobalamin biosynthesis.;Vitamin digestion and absorption;Cobalamin (Cbl, vitamin B12) transport and metabolism;Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD;Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC	PE1	1
+NX_Q9Y4W2	Ribosomal biogenesis protein LAS1L	734	83065	4.64	0	Cytoplasm;Centriolar satellite;Nucleolus;Nucleoplasm;Cytosol	Wilson-Turner X-linked mental retardation syndrome	Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.	NA	Belongs to the LAS1 family.	Major pathway of rRNA processing in the nucleolus and cytosol	PE1	X
+NX_Q9Y4W6	AFG3-like protein 2	797	88584	8.81	2	Mitochondrion inner membrane;Mitochondrion	Spastic ataxia 5, autosomal recessive;Spinocerebellar ataxia 28	ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048). Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form (By similarity).	Upon import into the mitochondrion, the N-terminal transit peptide is cleaved to generate an intermediate form which undergoes autocatalytic proteolytic processing to generate the proteolytically active mature form.	In the N-terminal section; belongs to the AAA ATPase family.;In the C-terminal section; belongs to the peptidase M41 family.	Processing of SMDT1	PE1	18
+NX_Q9Y4X0	AMME syndrome candidate gene 1 protein	333	35463	8.96	0	Nucleoplasm;Mitochondrion;Nucleus	Midface hypoplasia, hearing impairment, elliptocytosis, and nephrocalcinosis;Alport syndrome with mental retardation, midface hypoplasia and elliptocytosis	NA	NA	NA	NA	PE1	X
+NX_Q9Y4X1	UDP-glucuronosyltransferase 2A1	527	59926	9.07	1	Membrane	NA	UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.	NA	Belongs to the UDP-glycosyltransferase family.	Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Other types of O-glycan biosynthesis;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Glucuronidation	PE1	4
+NX_Q9Y4X3	C-C motif chemokine 27	112	12618	8.95	0	Secreted	NA	Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.	NA	Belongs to the intercrine beta (chemokine CC) family.	Cytokine-cytokine receptor interaction;Chemokine signaling pathway;Intestinal immune network for IgA production;G alpha (i) signalling events;Chemokine receptors bind chemokines	PE1	9
+NX_Q9Y4X4	Krueppel-like factor 12	402	44240	9.74	0	Nucleoplasm;Cytosol;Nucleus	NA	Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.	NA	Belongs to the Sp1 C2H2-type zinc-finger protein family.	NA	PE1	13
+NX_Q9Y4X5	E3 ubiquitin-protein ligase ARIH1	557	64118	4.97	0	Cajal body;Golgi apparatus;Cytoplasm;Nucleoplasm;Nucleus	NA	E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916).	NA	Belongs to the RBR family. Ariadne subfamily.	Protein modification; protein ubiquitination.;ISG15 antiviral mechanism	PE1	15
+NX_Q9Y4Y9	U6 snRNA-associated Sm-like protein LSm5	91	9937	4.42	0	Nucleus	NA	Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).	NA	Belongs to the snRNP Sm proteins family.	RNA degradation;Spliceosome;mRNA Splicing - Major Pathway;mRNA decay by 5' to 3' exoribonuclease	PE1	7
+NX_Q9Y4Z0	U6 snRNA-associated Sm-like protein LSm4	139	15350	10.02	0	Cytoplasmic vesicle;Nucleus	NA	Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).	NA	Belongs to the snRNP Sm proteins family.	RNA degradation;Spliceosome;mRNA Splicing - Major Pathway;mRNA decay by 5' to 3' exoribonuclease	PE1	19
+NX_Q9Y4Z2	Neurogenin-3	214	23077	9.61	0	Nucleoplasm;Nucleus speckle;Nucleus	Diarrhea 4, malabsorptive, congenital	Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).	NA	NA	Maturity onset diabetes of the young;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	PE1	10
+NX_Q9Y508	E3 ubiquitin-protein ligase RNF114	228	25694	6.99	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Acts also as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis.	Autoubiquitinated. Polyubiquitinated in the presence of E2 enzymes UBE2D1, UBE2D2 and UBE2D3, but only monoubiquitinated in the presence of UBE2E1.	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation	PE1	20
+NX_Q9Y512	Sorting and assembly machinery component 50 homolog	469	51976	6.44	0	Mitochondrion outer membrane;Cytoplasm;Mitochondrion	NA	Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes (PubMed:22252321, PubMed:25781180). Required for the assembly of TOMM40 into the TOM complex (PubMed:15644312).	NA	Belongs to the SAM50/omp85 family.	Mitochondrial protein import;Cristae formation	PE1	22
+NX_Q9Y519	Transmembrane protein 184B	407	45562	6.45	7	Membrane;Nucleoplasm;Cytosol;Golgi apparatus	NA	May activate the MAP kinase signaling pathway.	NA	Belongs to the TMEM184 family.	NA	PE1	22
+NX_Q9Y520	Protein PRRC2C	2896	316911	9.17	0	Cytosol	NA	NA	NA	NA	NA	PE1	1
+NX_Q9Y530	ADP-ribose glycohydrolase OARD1	152	17025	8.55	0	Nucleoplasm;Nucleolus;Chromosome	NA	ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose (PubMed:23481255, PubMed:23474714, PubMed:21849506). Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins (PubMed:23481255, PubMed:23474714). Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1 (PubMed:23481255). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21849506). Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively (PubMed:21849506).	NA	NA	NA	PE1	6
+NX_Q9Y534	Cold shock domain-containing protein C2	153	16786	7.02	0	Cytoplasm;Nucleoplasm;Nucleus;Cytosol	NA	RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity).	NA	NA	NA	PE1	22
+NX_Q9Y535	DNA-directed RNA polymerase III subunit RPC8	204	22918	4.47	0	Nucleoplasm;Centrosome;Nucleus;Cytoplasmic vesicle	NA	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).	NA	Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Cytosolic sensors of pathogen-associated DNA;RNA Polymerase III Chain Elongation;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter	PE1	22
+NX_Q9Y536	Peptidyl-prolyl cis-trans isomerase A-like 4A	164	18182	9.32	0	Cytoplasm	NA	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).	NA	Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.	NA	PE1	1
+NX_Q9Y543	Transcription factor HES-2	173	18470	9.88	0	Nucleus	NA	Transcriptional repressor of genes that require a bHLH protein for their transcription.	NA	NA	NA	PE2	1
+NX_Q9Y546	Leucine-rich repeat-containing protein 42	428	48571	7.2	0	Nucleoplasm	NA	NA	NA	Belongs to the LRRC42 family.	NA	PE1	1
+NX_Q9Y547	Intraflagellar transport protein 25 homolog	144	16297	4.93	0	Nucleoplasm;Cytosol;Cilium	NA	Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).	NA	Belongs to the IFT25 family.	Intraflagellar transport	PE1	1
+NX_Q9Y548	Protein YIPF1	306	34277	5.13	5	cis-Golgi network membrane;trans-Golgi network membrane;Endoplasmic reticulum;Nucleoplasm;Late endosome membrane	NA	NA	NA	Belongs to the YIP1 family.	NA	PE1	1
+NX_Q9Y561	Low-density lipoprotein receptor-related protein 12	859	94984	5.07	1	Mitochondrion;Cell membrane;Coated pit;Nucleolus;Membrane	NA	Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.	NA	Belongs to the LDLR family.	Retinoid metabolism and transport	PE1	8
+NX_Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	2161	224959	8.29	0	Cytoplasm;Postsynaptic density;Synapse;Cell membrane	NA	Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.	NA	Belongs to the SHANK family.	Glutamatergic synapse;Neurexins and neuroligins	PE1	19
+NX_Q9Y570	Protein phosphatase methylesterase 1	386	42315	5.67	0	Nucleoplasm;Nucleus	NA	Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.	Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.;PPME1 is phosphorylated by SIK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the AB hydrolase superfamily.	Cyclin A/B1/B2 associated events during G2/M transition	PE1	11
+NX_Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	518	56887	6.08	0	Cytosol;Mitochondrion;Cell membrane	NA	Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.	RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the necroptotic function of RIPK3. Phosphorylation at Ser-227 is required for binding MLKL (PubMed:11734559, PubMed:19524512, PubMed:22265413). Phosphorylation at Thr-182 is important for its kinase activity, interaction with PELI1 and PELI1-mediated 'Lys-48'-linked polyubiquitination and for its ability to mediate TNF-induced necroptosis (PubMed:29883609).;Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B (PubMed:21931591). Polyubiquitinated with 'Lys-48'-linked chains by PELI1 leading to its subsequent proteasome-dependent degradation. Ubiquitinated by STUB1 leading to its subsequent proteasome-dependent degradation (PubMed:29883609).	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.	Cytosolic DNA-sensing pathway;TRP channels;RIP-mediated NFkB activation via ZBP1;TRIF-mediated programmed cell death;IKK complex recruitment mediated by RIP1;RIPK1-mediated regulated necrosis;TICAM1, RIP1-mediated IKK complex recruitment;TLR3-mediated TICAM1-dependent programmed cell death	PE1	14
+NX_Q9Y573	Actin-binding protein IPP	584	65261	5.49	0	Cytoskeleton	NA	May play a role in organizing the actin cytoskeleton.	NA	NA	NA	PE1	1
+NX_Q9Y574	Ankyrin repeat and SOCS box protein 4	426	48195	7.57	0	NA	NA	Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).	Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation.	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	7
+NX_Q9Y575	Ankyrin repeat and SOCS box protein 3	518	57745	5.84	0	NA	NA	Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	2
+NX_Q9Y576	Ankyrin repeat and SOCS box protein 1	335	37014	8.55	0	Nucleoplasm	NA	May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	NA	Belongs to the ankyrin SOCS box (ASB) family.	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	2
+NX_Q9Y577	E3 ubiquitin-protein ligase TRIM17	477	54418	6.62	0	Cytoplasmic vesicle	NA	May function as a ubiquitin E3 ligase.	Auto-ubiquitinated.	Belongs to the TRIM/RBCC family.	Protein modification; protein ubiquitination.;Interferon gamma signaling	PE1	1
+NX_Q9Y580	RNA-binding protein 7	266	30504	9.56	0	Nucleoplasm;Nucleus	NA	Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Possible involved in germ cell RNA processing and meiosis (Probable).	NA	NA	NA	PE1	11
+NX_Q9Y581	Insulin-like peptide INSL6	213	24860	9.71	0	Secreted	NA	May have a role in sperm development and fertilization.	NA	Belongs to the insulin family.	NA	PE1	9
+NX_Q9Y584	Mitochondrial import inner membrane translocase subunit Tim22	194	20031	7.51	3	Mitochondrion inner membrane	NA	Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).	Disulfide bonds promote efficient assembly of the TIM22 complex.	Belongs to the Tim17/Tim22/Tim23 family.	Mitochondrial protein import	PE1	17
+NX_Q9Y585	Olfactory receptor 1A2	309	34396	8.81	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	17
+NX_Q9Y586	Protein mab-21-like 2	359	40923	8.87	0	Cytoplasm;Nucleus	Microphthalmia/coloboma and skeletal dysplasia syndrome	Required for several aspects of embryonic development including normal development of the eye.	NA	Belongs to the mab-21 family.	NA	PE1	4
+NX_Q9Y587	AP-4 complex subunit sigma-1	144	17005	5.08	0	Cytoplasmic vesicle;trans-Golgi network membrane	Spastic paraplegia 52, autosomal recessive	Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).	NA	Belongs to the adaptor complexes small subunit family.	Lysosome;Lysosome Vesicle Biogenesis	PE1	14
+NX_Q9Y592	Centrosomal protein of 83 kDa	701	82940	5.9	0	Golgi apparatus;Nucleoplasm;Centriole	Nephronophthisis 18	Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly.	NA	Belongs to the CEP83 family.	Anchoring of the basal body to the plasma membrane	PE1	12
+NX_Q9Y597	BTB/POZ domain-containing protein KCTD3	815	88984	6.58	0	Cytosol;Cell membrane	NA	Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics.	NA	Belongs to the KCTD3 family.	NA	PE1	1
+NX_Q9Y5A6	Zinc finger and SCAN domain-containing protein 21	473	53658	7.81	0	Endoplasmic reticulum;Nucleus	NA	Strong transcriptional activator.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	7
+NX_Q9Y5A7	NEDD8 ultimate buster 1	615	70538	5.71	0	Nucleoplasm;Nucleolus;Nucleus	NA	Promotes the degradation of NEDD8 more efficiently than isoform 2.;Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation.	NA	NA	Neddylation	PE1	7
+NX_Q9Y5A9	YTH domain-containing family protein 2	579	62334	8.87	0	Cytoplasm;Cytosol;P-body;Nucleus	NA	(Microbial infection) Promotes viral gene expression and replication of polyomavirus SV40: acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29447282).;Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:22575960, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context (PubMed:24284625, PubMed:26046440, PubMed:27558897, PubMed:30930054). M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex (PubMed:30930054). Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (PubMed:27558897). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (PubMed:30065315). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (By similarity). Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts (PubMed:30428350). Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation (PubMed:30559377). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103).;(Microbial infection) Promotes viral gene expression and virion production of kaposis sarcoma-associated herpesvirus (KSHV) at some stage of the KSHV life cycle (in iSLK.219 and iSLK.BAC16 cells) (PubMed:29659627). Acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29659627).	NA	Belongs to the YTHDF2 family.	NA	PE1	1
+NX_Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	961	104399	5.17	0	Nucleoplasm;Spindle pole;Centrosome;Cytoplasmic vesicle;Nucleus;Midbody	Congenital cataracts, facial dysmorphism, and neuropathy	Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.	Phosphorylated. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The phosphorylation is required for the physical interaction with GTF2F1.	NA	Formation of RNA Pol II elongation complex;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes	PE1	18
+NX_Q9Y5B6	PAX3- and PAX7-binding protein 1	917	104804	5.52	0	Nucleoplasm;Cytosol;Nucleus	NA	Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity).	NA	Belongs to the GCF family.	NA	PE1	21
+NX_Q9Y5B8	Nucleoside diphosphate kinase 7	376	42492	6.03	0	Mitochondrion	NA	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	NA	Belongs to the NDK family.	Purine metabolism;Pyrimidine metabolism;Metabolic pathways;Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes	PE1	1
+NX_Q9Y5B9	FACT complex subunit SPT16	1047	119914	5.5	0	Nucleoplasm;Nucleolus;Nucleus;Chromosome	NA	Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).	ADP-ribosylated. ADP-ribosylation by PARP1 is induced by genotoxic stress and correlates with dissociation of FACT from chromatin.	Belongs to the peptidase M24 family. SPT16 subfamily.	Formation of RNA Pol II elongation complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;RNA Polymerase II Pre-transcription Events;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Transcription Elongation;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation	PE1	14
+NX_Q9Y5C1	Angiopoietin-related protein 3	460	53637	6.24	0	Lamellipodium;Secreted	Hypobetalipoproteinemia, familial, 2	ANGPTL3(17-221): In vitro inhibits LPL activity; not effective on GPIHBP1-stabilized LPL.;Involved in angiogenesis. Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration (PubMed:11877390). Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling (PubMed:18535744). May increase the motility of podocytes. May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation. Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS (By similarity).;Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12909640, PubMed:23661675, PubMed:25495645). Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1 (PubMed:12097324, PubMed:19318355, PubMed:20581395). Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids (PubMed:17110602, PubMed:19028676). Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906). Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food; the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT (By similarity). Contributes to lower plasma levels of low density lipoprotein (LDL)-cholesterol by a mechanism that is independent of the canonical pathway implicating APOE and LDLR. May stimulate hypothalamic LPL activity (By similarity).	In part proteolytically cleaved by proprotein convertases; proposed to be involved in activation.;O-glycosylated at Thr-226 by GALNT2; blocks processing and activation by proprotein convertases.	NA	Assembly of active LPL and LIPC lipase complexes	PE1	1
+NX_Q9Y5E1	Protocadherin beta-9	797	87099	4.88	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5E2	Protocadherin beta-7	793	86707	4.9	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5E3	Protocadherin beta-6	794	87350	4.89	1	Nucleoplasm;Cytosol;Cell membrane	NA	Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5E4	Protocadherin beta-5	795	86423	4.87	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5E5	Protocadherin beta-4	795	87270	5.05	1	Cytosol;Cell membrane;Cytoskeleton	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5E6	Protocadherin beta-3	796	86714	4.86	1	Cytoplasmic vesicle;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5E7	Protocadherin beta-2	798	87254	4.76	1	Nucleoplasm;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5E8	Protocadherin beta-15	787	86329	4.74	1	Mitochondrion;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5E9	Protocadherin beta-14	798	87548	4.81	1	Cytoplasmic vesicle;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5F0	Protocadherin beta-13	798	87552	4.81	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5F1	Protocadherin beta-12	795	86770	4.72	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5F2	Protocadherin beta-11	797	87088	4.74	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5F3	Protocadherin beta-1	818	90491	5.2	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5F6	Protocadherin gamma-C5	944	101921	4.85	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5F7	Protocadherin gamma-C4	938	101214	5.16	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5F8	Protocadherin gamma-B7	929	100974	4.94	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5F9	Protocadherin gamma-B6	930	101043	5.09	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5G0	Protocadherin gamma-B5	923	99875	4.92	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5G1	Protocadherin gamma-B3	929	101204	4.87	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5G2	Protocadherin gamma-B2	931	100875	4.89	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5G3	Protocadherin gamma-B1	927	100360	4.92	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5G4	Protocadherin gamma-A9	932	101687	4.91	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5G5	Protocadherin gamma-A8	932	101480	5.1	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE2	5
+NX_Q9Y5G6	Protocadherin gamma-A7	932	101722	4.73	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5G7	Protocadherin gamma-A6	932	100871	4.75	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5G8	Protocadherin gamma-A5	931	100935	4.71	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE2	5
+NX_Q9Y5G9	Protocadherin gamma-A4	962	103968	4.79	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5H0	Protocadherin gamma-A3	932	100971	4.86	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5H1	Protocadherin gamma-A2	932	101484	4.85	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5H2	Protocadherin gamma-A11	935	101543	4.81	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5H3	Protocadherin gamma-A10	936	101447	4.78	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5H4	Protocadherin gamma-A1	931	101226	4.87	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE2	5
+NX_Q9Y5H5	Protocadherin alpha-9	950	102402	4.94	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE2	5
+NX_Q9Y5H6	Protocadherin alpha-8	950	103051	5.13	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5H7	Protocadherin alpha-5	936	102048	5.28	1	Nucleus speckle;Mitochondrion;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5H8	Protocadherin alpha-3	950	102428	4.95	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5H9	Protocadherin alpha-2	948	102063	5.08	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5I0	Protocadherin alpha-13	950	102483	5.08	1	Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5I1	Protocadherin alpha-11	949	103298	5.22	1	Cytoplasmic vesicle;Cytosol;Cell junction;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5I2	Protocadherin alpha-10	948	102875	5.04	1	Secreted;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5I3	Protocadherin alpha-1	950	102952	5.03	1	Secreted;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5I4	Protocadherin alpha-C2	1007	109450	5.26	1	Nucleoplasm;Mitochondrion;Cell membrane	NA	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	NA	NA	NA	PE1	5
+NX_Q9Y5I7	Claudin-16	305	33836	8.26	4	Tight junction;Cell membrane	Hypomagnesemia 3	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.	NA	Belongs to the claudin family.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C;Tight junction interactions	PE1	3
+NX_Q9Y5J1	U3 small nucleolar RNA-associated protein 18 homolog	556	62004	8.93	0	Nucleoplasm;Nucleus membrane;Nucleolus	NA	Involved in nucleolar processing of pre-18S ribosomal RNA.	NA	Belongs to the WD repeat UTP18 family.	Ribosome biogenesis in eukaryotes;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	17
+NX_Q9Y5J3	Hairy/enhancer-of-split related with YRPW motif protein 1	304	32613	8.99	0	Nucleus;Nucleoplasm;Cytosol;Nucleus membrane	NA	Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).	NA	Belongs to the HEY family.	NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;RUNX2 regulates osteoblast differentiation;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription	PE1	8
+NX_Q9Y5J5	Pleckstrin homology-like domain family A member 3	127	13891	9.72	0	Membrane;Cytoplasm	NA	P53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.	NA	Belongs to the PHLDA3 family.	NA	PE1	1
+NX_Q9Y5J6	Mitochondrial import inner membrane translocase subunit Tim10 B	103	11586	6.95	0	Mitochondrion inner membrane	NA	Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.	NA	Belongs to the small Tim family.	Mitochondrial protein import	PE1	11
+NX_Q9Y5J7	Mitochondrial import inner membrane translocase subunit Tim9	89	10378	6.71	0	Mitochondrion inner membrane;Mitochondrion	NA	Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.	NA	Belongs to the small Tim family.	Mitochondrial protein import	PE1	14
+NX_Q9Y5J9	Mitochondrial import inner membrane translocase subunit Tim8 B	83	9344	5.02	0	Mitochondrion inner membrane	NA	Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).	NA	Belongs to the small Tim family.	Mitochondrial protein import	PE1	11
+NX_Q9Y5K1	Meiotic recombination protein SPO11	396	44537	9.05	0	Nucleus	NA	Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.	NA	Belongs to the TOP6A family.	Meiotic recombination	PE2	20
+NX_Q9Y5K2	Kallikrein-4	254	27032	4.8	0	Secreted	Amelogenesis imperfecta, hypomaturation type, 2A1	Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).	N-glycosylated. The N-glycan structures are of complex diantennary or triantennary type, which may be further modified with up to 2 sialic acid residues.	Belongs to the peptidase S1 family. Kallikrein subfamily.	NA	PE1	19
+NX_Q9Y5K3	Choline-phosphate cytidylyltransferase B	369	41940	5.99	0	Endoplasmic reticulum	NA	Controls phosphatidylcholine synthesis.	Extensively phosphorylated. The beta-1 isoform seems to be much less phosphorylated.	Belongs to the cytidylyltransferase family.	Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.;Glycerophospholipid metabolism;Metabolic pathways;Synthesis of PC	PE1	X
+NX_Q9Y5K5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	329	37607	5.23	0	Cytoplasm;Nucleoplasm;Mitochondrion;Nucleus	NA	Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.	NA	Belongs to the peptidase C12 family.	Downregulation of TGF-beta receptor signaling;UCH proteinases	PE1	1
+NX_Q9Y5K6	CD2-associated protein	639	71451	6.07	0	Cytoplasm;Cell membrane;Cell junction;Nucleolus;Ruffle;Cytosol;Cytoskeleton	Focal segmental glomerulosclerosis 3	Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260).	Phosphorylated on tyrosine residues; probably by c-Abl, Fyn and c-Src.	NA	Bacterial invasion of epithelial cells;Nephrin family interactions	PE1	6
+NX_Q9Y5K8	V-type proton ATPase subunit D	247	28263	9.36	0	Membrane;Nucleoplasm	NA	Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.	NA	Belongs to the V-ATPase D subunit family.	Oxidative phosphorylation;Metabolic pathways;Phagosome;Synaptic vesicle cycle;Collecting duct acid secretion;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;Rheumatoid arthritis;Transferrin endocytosis and recycling;ROS and RNS production in phagocytes;Insulin receptor recycling;Ion channel transport;Neutrophil degranulation	PE1	14
+NX_Q9Y5L0	Transportin-3	923	104203	5.35	0	Cytoplasmic vesicle;Cytoplasm;Nucleus	Muscular dystrophy, limb-girdle, autosomal dominant 2	Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains.	NA	NA	NA	PE1	7
+NX_Q9Y5L2	Hypoxia-inducible lipid droplet-associated protein	63	6950	6.71	1	Membrane;Nucleoplasm;Secreted;Lipid droplet	NA	Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.	NA	NA	Lipid particle organization	PE1	7
+NX_Q9Y5L3	Ectonucleoside triphosphate diphosphohydrolase 2	495	53665	8.58	2	Endoplasmic reticulum membrane;Cell membrane	NA	In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.	NA	Belongs to the GDA1/CD39 NTPase family.	Purine metabolism;Phosphate bond hydrolysis by NTPDase proteins	PE1	9
+NX_Q9Y5L4	Mitochondrial import inner membrane translocase subunit Tim13	95	10500	8.42	0	Mitochondrion inner membrane;Mitochondrion;Nucleolus	NA	Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins.	NA	Belongs to the small Tim family.	Mitochondrial protein import	PE1	19
+NX_Q9Y5L5	Lens epithelial cell protein LEP503	61	6908	8.61	0	NA	NA	May play a role in lens epithelial cell differentiation.	NA	NA	NA	PE2	1
+NX_Q9Y5M1	Uncharacterized protein FAM215A	114	11973	7.75	0	NA	NA	NA	NA	NA	NA	PE5	17
+NX_Q9Y5M6	Oculomedin	44	5321	9.78	0	NA	NA	NA	NA	NA	NA	PE2	1
+NX_Q9Y5M8	Signal recognition particle receptor subunit beta	271	29702	9.17	1	Endoplasmic reticulum membrane;Cell membrane	NA	Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).	NA	Belongs to the SRP receptor beta subunit family.	Protein export;XBP1(S) activates chaperone genes;SRP-dependent cotranslational protein targeting to membrane	PE1	3
+NX_Q9Y5N1	Histamine H3 receptor	445	48671	9.43	7	Cell membrane	NA	The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (i) signalling events;Histamine receptors	PE1	20
+NX_Q9Y5N5	Methyltransferase N6AMT1	214	22957	5.02	0	Nucleoplasm;Centrosome;Nucleus	NA	Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146) (By similarity). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008). Also acts as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:30017583). N(6)-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation (PubMed:30017583). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655).	NA	Belongs to the eukaryotic/archaeal PrmC-related family.	Methylation;Eukaryotic Translation Termination	PE1	21
+NX_Q9Y5N6	Origin recognition complex subunit 6	252	28107	8.91	0	Nucleoplasm;Nucleolus;Nucleus	Meier-Gorlin syndrome 3	Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.	NA	Belongs to the ORC6 family.	Cell cycle;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;Activation of ATR in response to replication stress;CDC6 association with the ORC:origin complex;Assembly of the pre-replicative complex;Activation of the pre-replicative complex;E2F-enabled inhibition of pre-replication complex formation;Assembly of the ORC complex at the origin of replication	PE1	16
+NX_Q9Y5P0	Olfactory receptor 51B4	310	34912	8.35	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9Y5P1	Olfactory receptor 51B2	312	35373	8.94	7	Cell membrane	NA	Odorant receptor.	NA	Belongs to the G-protein coupled receptor 1 family.	Olfactory transduction;Olfactory Signaling Pathway	PE2	11
+NX_Q9Y5P2	Chondrosarcoma-associated gene 2/3 protein	127	14430	10.33	0	NA	NA	Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype.	NA	NA	NA	PE2	X
+NX_Q9Y5P3	Retinoic acid-induced protein 2	530	57180	5.14	0	Cell membrane	NA	NA	NA	NA	NA	PE1	X
+NX_Q9Y5P4	Ceramide transfer protein	624	70835	5.29	0	Endoplasmic reticulum;Golgi apparatus;Nucleoplasm;Cytoplasm	Mental retardation, autosomal dominant 34	Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.	Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.;COL4A3BP is phosphorylated by CSNK1G2	NA	Sphingolipid de novo biosynthesis	PE1	5
+NX_Q9Y5P6	Mannose-1-phosphate guanyltransferase beta	360	39834	6.16	0	Nucleoplasm;Cytoplasm	Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A14;Muscular dystrophy-dystroglycanopathy congenital with mental retardation B14;Muscular dystrophy-dystroglycanopathy limb-girdle C14	Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids.	NA	Belongs to the transferase hexapeptide repeat family.	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.;Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Synthesis of GDP-mannose	PE1	3
+NX_Q9Y5P8	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta	575	65061	5.01	0	Nucleoplasm;Nucleus	NA	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	NA	NA	mRNA surveillance pathway;Dopaminergic synapse;Cyclin A/B1/B2 associated events during G2/M transition;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Cyclin D associated events in G1	PE1	X
+NX_Q9Y5Q0	Fatty acid desaturase 3	445	51145	7.42	4	Endoplasmic reticulum membrane;Nucleolus	NA	Acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate) at carbon 13 to generate (11E,13Z)-octadecadienoate, likely participating in the biohydrogenation pathway of linoleic acid (LA) (18:2n-6).	NA	Belongs to the fatty acid desaturase type 1 family.	Lipid metabolism; polyunsaturated fatty acid biosynthesis.	PE1	11
+NX_Q9Y5Q3	Transcription factor MafB	323	35792	7.17	0	Golgi apparatus;Nucleolus;Nucleoplasm;Cytosol;Nucleus	Multicentric carpotarsal osteolysis syndrome;Duane retraction syndrome 3 with or without deafness	Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.	Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors (By similarity).;Phosphorylated by GSK3 and MAPK13 on serine and threonine residues.	Belongs to the bZIP family. Maf subfamily.	Activation of anterior HOX genes in hindbrain development during early embryogenesis	PE1	20
+NX_Q9Y5Q5	Atrial natriuretic peptide-converting enzyme	1042	116486	4.87	1	Nucleus;Secreted;Cytoskeleton;Cell membrane	Pre-eclampsia/eclampsia 5	Has weaker endopeptidase activity compared to isoform 1.;Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.	Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Different soluble forms are produced by cleavage and autocatalytic cleavage: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10, while 160 kDa and 100 kDa soluble fragments are produced by autocatalytic cleavage. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1.;A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with soluble fragments (100 kDa, 160 kDa and 180 kDa fragments).;N-glycosylated; required for processing and activation.	Belongs to the peptidase S1 family.	Physiological factors	PE1	4
+NX_Q9Y5Q6	Insulin-like peptide INSL5	135	15333	6.81	0	Secreted	NA	May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.	NA	Belongs to the insulin family.	G alpha (i) signalling events;Relaxin receptors	PE1	1
+NX_Q9Y5Q8	General transcription factor 3C polypeptide 5	519	59571	6.47	0	Nucleoplasm;Nucleus	NA	Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.	NA	Belongs to the TFIIIC subunit 5 family.	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter	PE1	9
+NX_Q9Y5Q9	General transcription factor 3C polypeptide 3	886	101272	4.98	0	Nucleoplasm;Nucleus;Nucleus membrane	NA	Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.	NA	NA	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter	PE1	2
+NX_Q9Y5R2	Matrix metalloproteinase-24	645	73231	9.3	1	trans-Golgi network membrane;Extracellular matrix;Nucleolus;Cell membrane	NA	Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).	Cleaved by a furin endopeptidase in the trans-Golgi network.	Belongs to the peptidase M10A family.	Activation of Matrix Metalloproteinases	PE1	20
+NX_Q9Y5R4	MTRF1L release factor glutamine methyltransferase	338	38231	6.22	0	Mitochondrion	NA	N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L.	NA	Belongs to the protein N5-glutamine methyltransferase family.	Histidine metabolism;Tyrosine metabolism	PE1	3
+NX_Q9Y5R5	Doublesex- and mab-3-related transcription factor 2	561	61814	6.37	0	Nucleus	NA	Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity).	NA	Belongs to the DMRT family.	NA	PE1	9
+NX_Q9Y5R6	Doublesex- and mab-3-related transcription factor 1	373	39473	7.54	0	Nucleus	Testicular germ cell tumor;46,XY sex reversal 4	Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).	NA	Belongs to the DMRT family.	NA	PE1	9
+NX_Q9Y5R8	Trafficking protein particle complex subunit 1	145	16832	9.23	0	cis-Golgi network;Endoplasmic reticulum	NA	May play a role in vesicular transport from endoplasmic reticulum to Golgi.	NA	Belongs to the TRAPP small subunits family. BET5 subfamily.	COPII-mediated vesicle transport;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs	PE1	17
+NX_Q9Y5S1	Transient receptor potential cation channel subfamily V member 2	764	85981	5.56	6	Cytoplasm;Melanosome;Cell membrane	NA	Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.	N-glycosylated.;Phosphorylated by PKA.	Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.	TRP channels	PE1	17
+NX_Q9Y5S2	Serine/threonine-protein kinase MRCK beta	1711	194315	5.97	0	Cytoplasm;Lamellipodium;Cell junction;Cell membrane	NA	Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).	NA	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.	NA	PE1	14
+NX_Q9Y5S8	NADPH oxidase 1	564	64871	8.79	6	Invadopodium membrane;Cell membrane	NA	NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.	NA	NA	Phagosome;Osteoclast differentiation;Leukocyte transendothelial migration;RHO GTPases Activate NADPH Oxidases	PE1	X
+NX_Q9Y5S9	RNA-binding protein 8A	174	19889	5.5	0	Cytoplasm;Nucleus speckle;Nucleus	Thrombocytopenia-absent radius syndrome	Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.	NA	Belongs to the RBM8A family.	RNA transport;mRNA surveillance pathway;Spliceosome;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Regulation of expression of SLITs and ROBOs;RNA Polymerase II Transcription Termination	PE1	1
+NX_Q9Y5T4	DnaJ homolog subfamily C member 15	150	16383	10.08	1	Mitochondrion inner membrane	NA	Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.	NA	NA	NA	PE1	13
+NX_Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	823	93570	6.5	0	Nucleoplasm;Cytosol;Nucleus	NA	Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.	Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.	Belongs to the peptidase C19 family. USP16 subfamily.	Ub-specific processing proteases	PE1	21
+NX_Q9Y5U2	Protein TSSC4	329	34326	5.07	0	Nucleoplasm;Cytosol	NA	NA	NA	Belongs to the TSSC4 family.	NA	PE1	11
+NX_Q9Y5U4	Insulin-induced gene 2 protein	225	24778	8.16	5	Endoplasmic reticulum membrane	NA	Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.	NA	Belongs to the INSIG family.	Regulation of cholesterol biosynthesis by SREBP (SREBF)	PE1	2
+NX_Q9Y5U5	Tumor necrosis factor receptor superfamily member 18	241	26000	5.97	1	Secreted;Cell membrane	NA	Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.	NA	NA	Cytokine-cytokine receptor interaction;TNFs bind their physiological receptors;RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	PE1	1
+NX_Q9Y5U8	Mitochondrial pyruvate carrier 1	109	12347	9.67	2	Mitochondrion inner membrane;Mitochondrion	Mitochondrial pyruvate carrier deficiency	Mediates the uptake of pyruvate into mitochondria.	NA	Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.	Pyruvate metabolism	PE1	6
+NX_Q9Y5U9	Immediate early response 3-interacting protein 1	82	8969	7.96	2	Endoplasmic reticulum;Endoplasmic reticulum membrane	Microcephaly, epilepsy, and diabetes syndrome	May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity).	NA	Belongs to the YOS1 family.	NA	PE1	18
+NX_Q9Y5V0	Zinc finger protein 706	76	8498	10.02	0	Cytoplasm;Nucleus;Cell membrane	NA	Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.	NA	NA	Generic Transcription Pathway	PE1	8
+NX_Q9Y5V3	Melanoma-associated antigen D1	778	86161	5.64	0	Cytoplasm;Cytosol;Nucleus;Cell membrane	NA	Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.	NA	NA	Neurotrophin signaling pathway;NRAGE signals death through JNK;Caspase activation via Dependence Receptors in the absence of ligand	PE1	X
+NX_Q9Y5W3	Krueppel-like factor 2	355	37420	9.06	0	Nucleoplasm;Nucleus	NA	Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758).	Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity).	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q9Y5W5	Wnt inhibitory factor 1	379	41528	7.84	0	Secreted	NA	Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.	NA	NA	Wnt signaling pathway;TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists	PE1	12
+NX_Q9Y5W7	Sorting nexin-14	946	110182	6.28	2	Cytosol;Lysosome membrane;Dendrite;Late endosome membrane	Spinocerebellar ataxia, autosomal recessive, 20	Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25848753, PubMed:25148684).	NA	Belongs to the sorting nexin family.	NA	PE1	6
+NX_Q9Y5W8	Sorting nexin-13	968	112189	6.15	0	Early endosome membrane	NA	May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas.	NA	Belongs to the sorting nexin family.	NA	PE1	7
+NX_Q9Y5W9	Sorting nexin-11	270	30433	6.61	0	Membrane;Endosome;Cytosol	NA	Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.	NA	Belongs to the sorting nexin family.	NA	PE1	17
+NX_Q9Y5X0	Sorting nexin-10	201	23598	5.5	0	Cytoplasm;Endosome membrane;Nucleolus;Nucleoplasm;Centrosome;Cytoskeleton	Osteopetrosis, autosomal recessive 8	Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.	NA	Belongs to the sorting nexin family.	NA	PE1	7
+NX_Q9Y5X1	Sorting nexin-9	595	66592	5.4	0	trans-Golgi network;Cytoplasm;Clathrin-coated vesicle;Cell membrane;Cytoplasmic vesicle membrane;Ruffle;Cytosol	NA	Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.	Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR.;Ubiquitinated by ITCH.	Belongs to the sorting nexin family.	Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis	PE1	6
+NX_Q9Y5X2	Sorting nexin-8	465	52569	6.96	0	Early endosome membrane;Cytoplasmic vesicle	NA	May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.	NA	Belongs to the sorting nexin family.	NA	PE1	7
+NX_Q9Y5X3	Sorting nexin-5	404	46816	6.31	0	Cytoplasm;Cell membrane;Early endosome;Cytoplasmic vesicle membrane;Endosome;Phagocytic cup;Ruffle;Early endosome membrane;Cytoplasmic vesicle;Cytosol	NA	Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941).	NA	Belongs to the sorting nexin family.	Golgi Associated Vesicle Biogenesis	PE1	20
+NX_Q9Y5X4	Photoreceptor-specific nuclear receptor	410	44692	8.17	0	Nucleus	Enhanced S cone syndrome;Retinitis pigmentosa 37	Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.	Di- and tri-sumoylated in developing retina. PIAS3-mediated sumoylation promotes repression of cone-specific gene expression and activation of rod-specific genes. Sumoylation on Lys-185 appears to be the main site (By similarity).	Belongs to the nuclear hormone receptor family. NR2 subfamily.	Nuclear Receptor transcription pathway	PE1	15
+NX_Q9Y5X5	Neuropeptide FF receptor 2	522	60270	9.43	7	Cytoskeleton;Cell membrane	NA	Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.	NA	Belongs to the G-protein coupled receptor 1 family.	Neuroactive ligand-receptor interaction;G alpha (q) signalling events;Orexin and neuropeptides FF and QRFP bind to their respective receptors	PE1	4
+NX_Q9Y5X9	Endothelial lipase	500	56795	8.13	0	Secreted	NA	Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.	NA	Belongs to the AB hydrolase superfamily. Lipase family.	Glycerolipid metabolism;Metabolic pathways;HDL remodeling	PE1	18
+NX_Q9Y5Y0	Feline leukemia virus subgroup C receptor-related protein 1	555	59863	5.72	12	Mitochondrion membrane;Cell junction;Cell membrane	Posterior column ataxia with retinitis pigmentosa	Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.;Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro.	N-Glycosylated.	Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.	Iron uptake and transport	PE1	1
+NX_Q9Y5Y2	Cytosolic Fe-S cluster assembly factor NUBP2	271	28825	5.55	0	Cytoplasm;Microtubule organizing center;Centriole;Nucleoplasm;Centrosome;Cilium axoneme;Cytosol;Nucleus	NA	Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.	NA	Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.	Cytosolic iron-sulfur cluster assembly	PE1	16
+NX_Q9Y5Y3	Probable G-protein coupled receptor 45	372	41967	9.45	7	Cell membrane	NA	Orphan receptor. May play a role in brain function.	NA	Belongs to the G-protein coupled receptor 1 family.	G alpha (s) signalling events	PE2	2
+NX_Q9Y5Y4	Prostaglandin D2 receptor 2	395	43268	10.52	7	Cell membrane	NA	Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.	Phosphorylated.	Belongs to the G-protein coupled receptor 1 family.	G alpha (i) signalling events;Prostanoid ligand receptors	PE1	11
+NX_Q9Y5Y5	Peroxisomal membrane protein PEX16	336	38629	9.85	2	Peroxisome membrane	Peroxisome biogenesis disorder complementation group 9;Peroxisome biogenesis disorder 8B;Peroxisome biogenesis disorder 8A	Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3.	NA	Belongs to the peroxin-16 family.	Peroxisome;Class I peroxisomal membrane protein import	PE1	11
+NX_Q9Y5Y6	Suppressor of tumorigenicity 14 protein	855	94770	6.11	1	Membrane;Cytoplasmic vesicle;Nucleoplasm	Ichthyosis, congenital, autosomal recessive 11	Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.	NA	Belongs to the peptidase S1 family.	Formation of the cornified envelope	PE1	11
+NX_Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	322	35213	8.59	1	Membrane	NA	Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.	O-glycosylated.	NA	Hyaluronan uptake and degradation	PE1	11
+NX_Q9Y5Y9	Sodium channel protein type 10 subunit alpha	1956	220626	5.67	24	Cell membrane	Episodic pain syndrome, familial, 2	Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.	Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.;Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 816) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.;Ubiquitinated by NEDD4L; which promotes its endocytosis.	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation	PE1	3
+NX_Q9Y5Z0	Beta-secretase 2	518	56180	5.05	1	Endoplasmic reticulum;Golgi apparatus;Endosome;Cell membrane	NA	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142).	Undergoes autoproteolytic cleavage.;Glycosylated.	Belongs to the peptidase A1 family.	Alzheimer's disease	PE1	21
+NX_Q9Y5Z4	Heme-binding protein 2	205	22875	4.58	0	Cytoplasm;Mitochondrion	NA	Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.	NA	Belongs to the HEBP family.	Neutrophil degranulation	PE1	6
+NX_Q9Y5Z6	Beta-1,3-galactosyltransferase 1	326	37993	9.38	1	Golgi apparatus membrane	NA	Beta-1,3-galactosyltransferase that transfers galactose from UDP-alpha-D-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.	NA	Belongs to the glycosyltransferase 31 family.	Protein modification; protein glycosylation.;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways;Lewis blood group biosynthesis	PE1	2
+NX_Q9Y5Z7	Host cell factor 2	792	86779	8.75	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	NA	NA	NA	Herpes simplex infection	PE1	12
+NX_Q9Y5Z9	UbiA prenyltransferase domain-containing protein 1	338	36831	8.4	8	Cytoplasm;Endoplasmic reticulum membrane;Golgi apparatus membrane;Mitochondrion membrane;Cytoplasmic vesicle;Nucleus	Corneal dystrophy, Schnyder type	Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.	NA	Belongs to the UbiA prenyltransferase family.	Cofactor biosynthesis; ubiquinone biosynthesis.;Quinol/quinone metabolism; menaquinone biosynthesis.;Metabolism of vitamin K	PE1	1
+NX_Q9Y600	Cysteine sulfinic acid decarboxylase	493	55023	6.06	0	NA	NA	Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate.	NA	Belongs to the group II decarboxylase family.	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2.;Taurine and hypotaurine metabolism;Metabolic pathways;Degradation of cysteine and homocysteine	PE1	12
+NX_Q9Y603	Transcription factor ETV7	341	38998	8.27	0	Nucleoplasm;Nucleus	NA	Does not seem to have a repressor activity.;Does not seem to have a repressor activity.;Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.	NA	Belongs to the ETS family.	Dorso-ventral axis formation	PE1	6
+NX_Q9Y605	MORF4 family-associated protein 1	127	14650	4.69	0	Nucleoplasm;Perinuclear region;Nucleus	NA	NA	NA	Belongs to the MORF4 family-associated protein family.	NA	PE1	4
+NX_Q9Y606	tRNA pseudouridine synthase A	427	47470	8.69	0	Nucleoplasm;Mitochondrion;Nucleus	Myopathy with lactic acidosis and sideroblastic anemia 1	Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 RNA.	NA	Belongs to the tRNA pseudouridine synthase TruA family.	tRNA modification in the nucleus and cytosol;tRNA modification in the mitochondrion	PE1	12
+NX_Q9Y608	Leucine-rich repeat flightless-interacting protein 2	721	82171	6.5	0	Cell membrane;Cytoskeleton	NA	May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.	Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88.	Belongs to the LRRFIP family.	NA	PE1	3
+NX_Q9Y613	FH1/FH2 domain-containing protein 1	1164	126551	6.01	0	Bleb;Cytoplasm;Cytosol;Cytoskeleton	NA	Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.	Phosphorylated by ROCK1.	Belongs to the formin homology family.	NA	PE1	16
+NX_Q9Y614	Actin-like protein 7B	415	45234	5.32	0	Cytoskeleton	NA	NA	NA	Belongs to the actin family.	NA	PE1	9
+NX_Q9Y615	Actin-like protein 7A	435	48644	6.64	0	Golgi apparatus;Cytoplasm;Nucleus;Cytoskeleton	NA	NA	NA	Belongs to the actin family.	NA	PE1	9
+NX_Q9Y616	Interleukin-1 receptor-associated kinase 3	596	67767	6.25	0	Cytoplasmic vesicle	Asthma-related traits 5	Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.	IRAK3 is phosphorylated by IRAK1 (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.	Apoptosis;Neurotrophin signaling pathway;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Interleukin-1 signaling	PE1	12
+NX_Q9Y617	Phosphoserine aminotransferase	370	40423	7.56	0	Cytosol	Neu-Laxova syndrome 2;Phosphoserine aminotransferase deficiency	Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.	NA	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.	Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.;Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.;Glycine, serine and threonine metabolism;Vitamin B6 metabolism;Metabolic pathways;Serine biosynthesis	PE1	9
+NX_Q9Y618	Nuclear receptor corepressor 2	2514	273657	7.21	0	Nucleoplasm;Nucleus	NA	Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.;Have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).	NA	Belongs to the N-CoR nuclear receptor corepressors family.	Notch signaling pathway;PPARA activates gene expression;Downregulation of SMAD2/3:SMAD4 transcriptional activity;HDACs deacetylate histones;Notch-HLH transcription pathway;Nuclear Receptor transcription pathway;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);SUMOylation of transcription cofactors;Regulation of MECP2 expression and activity;Loss of MECP2 binding ability to the NCoR/SMRT complex	PE1	12
+NX_Q9Y619	Mitochondrial ornithine transporter 1	301	32736	9.28	6	Mitochondrion inner membrane	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	Ornithine-citrulline antiporter. Connects the cytosolic and the intramitochondrial reactions of the urea cycle by exchanging cytosolic ornithine with matrix citrulline (PubMed:12807890). The stoichiometry is close to 1:1 (By similarity).	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	Urea cycle	PE1	13
+NX_Q9Y620	DNA repair and recombination protein RAD54B	910	102967	8.44	0	Nucleus	NA	Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group.	NA	Belongs to the SNF2/RAD54 helicase family.	Homologous recombination	PE1	8
+NX_Q9Y623	Myosin-4	1939	223071	5.65	0	Myofibril	NA	Muscle contraction.	NA	Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Tight junction;Viral myocarditis	PE1	17
+NX_Q9Y624	Junctional adhesion molecule A	299	32583	8.09	1	Tight junction;Cell junction;Cytoskeleton;Cell membrane	NA	(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.;(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.;Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).	N-glycosylated.	Belongs to the immunoglobulin superfamily.	Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Epithelial cell signaling in Helicobacter pylori infection;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Tight junction interactions;Integrin cell surface interactions;Cell surface interactions at the vascular wall	PE1	1
+NX_Q9Y625	Glypican-6	555	62736	5.29	0	Cytoplasmic vesicle;Golgi apparatus;Cell membrane;Extracellular space	Omodysplasia 1	Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling.	NA	Belongs to the glypican family.	Retinoid metabolism and transport;HS-GAG biosynthesis;A tetrasaccharide linker sequence is required for GAG synthesis;HS-GAG degradation;Defective B4GALT7 causes EDS, progeroid type;Defective B3GAT3 causes JDSSDHD;Defective EXT2 causes exostoses 2;Defective EXT1 causes exostoses 1, TRPS2 and CHDS;Defective B3GALT6 causes EDSP2 and SEMDJL1	PE1	13
+NX_Q9Y639	Neuroplastin	398	44387	8.11	1	Mitochondrion;Postsynaptic density;Cytoskeleton;Cell membrane	NA	Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity).	NA	NA	GABA receptor activation	PE1	15
+NX_Q9Y644	Beta-1,3-N-acetylglucosaminyltransferase radical fringe	331	36424	9.3	1	Nucleoplasm;Golgi apparatus membrane	NA	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis.	NA	Belongs to the glycosyltransferase 31 family.	Other types of O-glycan biosynthesis;Notch signaling pathway;Pre-NOTCH Processing in Golgi	PE1	17
+NX_Q9Y646	Carboxypeptidase Q	472	51888	5.79	0	Golgi apparatus;Secreted;Endoplasmic reticulum;Lysosome;Cytoplasmic vesicle	NA	Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.	N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains (By similarity).	Belongs to the peptidase M28 family.	NA	PE1	8
+NX_Q9Y651	Transcription factor SOX-21	276	28580	9.74	0	Nucleoplasm;Nucleus	NA	May play a role as an activator of transcription of OPRM1.	NA	NA	NA	PE1	13
+NX_Q9Y653	Adhesion G-protein coupled receptor G1	693	77738	8.79	7	Membrane raft;Secreted;Cell membrane	Polymicrogyria, bilateral frontoparietal;Polymicrogyria, bilateral perisylvian, autosomal recessive	ADGRG1 N-terminal fragment: Plays a critical role in cancer progression by activating VEGFA production and angiogenesis through a signaling pathway mediated by PRKCA (PubMed:21724588).;Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity).	Ubiquitinated. Undergoes polyubiquitination upon activation.;Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment (ADGRG1 NT) and the membrane-bound C-terminal fragment (ADGRG1 CT) predominantly remain associated and non-covalently linked. Shedding to yield the secreted ADGRG1 N-terminal fragment seems to involve metalloprotease(s) (PubMed:22333914).;N-glycosylated. Contains sialic acid residues.	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.	NA	PE1	16
+NX_Q9Y657	Spindlin-1	262	29601	6.46	0	Nucleoplasm;Nucleus;Nucleolus	NA	Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.	Phosphorylated during oocyte meiotic maturation.	Belongs to the SPIN/STSY family.	NA	PE1	9
+NX_Q9Y661	Heparan sulfate glucosamine 3-O-sulfotransferase 4	456	49799	8.82	1	Golgi apparatus membrane	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).	NA	Belongs to the sulfotransferase 1 family.	HS-GAG biosynthesis	PE1	16
+NX_Q9Y662	Heparan sulfate glucosamine 3-O-sulfotransferase 3B1	390	43324	9.67	1	Cytoplasmic vesicle;Golgi apparatus membrane	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.	NA	Belongs to the sulfotransferase 1 family.	Glycosaminoglycan biosynthesis - heparan sulfate;HS-GAG biosynthesis	PE1	17
+NX_Q9Y663	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	406	44900	9.54	1	Cytoskeleton;Golgi apparatus membrane	NA	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.	NA	Belongs to the sulfotransferase 1 family.	Glycosaminoglycan biosynthesis - heparan sulfate;HS-GAG biosynthesis	PE1	17
+NX_Q9Y664	KICSTOR complex protein kaptin	436	48080	5.12	0	Cell membrane;Lysosome membrane;Nucleoplasm;Lamellipodium;Stereocilium;Cytosol	Mental retardation, autosomal recessive 41	As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	NA	NA	NA	PE1	19
+NX_Q9Y666	Solute carrier family 12 member 7	1083	119106	6.28	12	Cytosol;Cell membrane	NA	Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).	NA	Belongs to the SLC12A transporter family.	Collecting duct acid secretion;Cation-coupled Chloride cotransporters	PE1	5
+NX_Q9Y672	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase	507	58121	8.8	11	Endoplasmic reticulum;Endoplasmic reticulum membrane	Congenital disorder of glycosylation 1C	Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.	NA	Belongs to the ALG6/ALG8 glucosyltransferase family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG6 causes ALG6-CDG (CDG-1c)	PE1	1
+NX_Q9Y673	Dolichyl-phosphate beta-glucosyltransferase	324	36946	9.34	1	Cytosol;Endoplasmic reticulum membrane	NA	NA	NA	Belongs to the glycosyltransferase 2 family.	Protein modification; protein glycosylation.;N-Glycan biosynthesis;Metabolic pathways;Synthesis of dolichyl-phosphate-glucose	PE1	13
+NX_Q9Y675	SNRPN upstream reading frame protein	71	8412	10.58	0	Nucleus	NA	NA	NA	Belongs to the SNURF family.	NA	PE1	15
+NX_Q9Y676	28S ribosomal protein S18b, mitochondrial	258	29396	9.47	0	Cytoplasm;Cell junction;Mitochondrion	NA	NA	NA	Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	6
+NX_Q9Y678	Coatomer subunit gamma-1	874	97718	5.32	0	Golgi apparatus;Cytoplasm;COPI-coated vesicle membrane;Nucleoplasm;Golgi apparatus membrane;Cytosol	NA	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity).	NA	Belongs to the COPG family.	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic	PE1	3
+NX_Q9Y679	Ancient ubiquitous protein 1	410	45787	8.96	1	Nucleoplasm;Endoplasmic reticulum membrane;Cytoplasmic vesicle	NA	May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.	NA	Belongs to the AUP1 family.	NA	PE1	2
+NX_Q9Y680	Peptidyl-prolyl cis-trans isomerase FKBP7	222	25794	5.92	0	Endoplasmic reticulum;Endoplasmic reticulum lumen	NA	PPIases accelerate the folding of proteins during protein synthesis.	Glycosylated.	NA	NA	PE1	2
+NX_Q9Y689	ADP-ribosylation factor-like protein 5A	179	20728	6.3	0	NA	NA	Lacks ADP-ribosylation enhancing activity.	NA	Belongs to the small GTPase superfamily. Arf family.	NA	PE1	2
+NX_Q9Y691	Calcium-activated potassium channel subunit beta-2	235	27130	8.71	2	Membrane	NA	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.	N-glycosylated.	Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.	Vascular smooth muscle contraction;Ca2+ activated K+ channels;cGMP effects	PE1	3
+NX_Q9Y692	Glucocorticoid modulatory element-binding protein 1	573	62591	4.76	0	Cytoplasm;Nucleoplasm;Nucleus	NA	Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.	NA	NA	NA	PE1	1
+NX_Q9Y693	LHFPL tetraspan subfamily member 6 protein	200	21598	7.87	3	Membrane;Nucleolus	NA	NA	NA	Belongs to the LHFP family.	NA	PE1	13
+NX_Q9Y694	Solute carrier family 22 member 7	548	60026	6.57	12	Basolateral cell membrane	NA	Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.	NA	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.	Bile secretion;Organic anion transport	PE1	6
+NX_Q9Y696	Chloride intracellular channel protein 4	253	28772	5.45	1	Cytoplasm;Mitochondrion;Cell membrane;Nucleus matrix;Cell junction;Cytoplasmic vesicle membrane;Centrosome;Cytosol;Nucleus	NA	Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).	NA	Belongs to the chloride channel CLIC family.	NA	PE1	1
+NX_Q9Y697	Cysteine desulfurase, mitochondrial	457	50196	8.54	0	Cytoplasm;Mitochondrion;Nucleoplasm;Cytosol;Nucleus	NA	Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor.	NA	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.	Thiamine metabolism;Sulfur relay system;Mitochondrial iron-sulfur cluster biogenesis;Molybdenum cofactor biosynthesis	PE1	20
+NX_Q9Y698	Voltage-dependent calcium channel gamma-2 subunit	323	35966	9.13	4	Membrane;Synaptosome	Mental retardation, autosomal dominant 10	Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.	Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4.	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	MAPK signaling pathway;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Presynaptic depolarization and calcium channel opening;Trafficking of AMPA receptors;LGI-ADAM interactions;Phase 2 - plateau phase;Phase 0 - rapid depolarisation	PE1	22
+NX_Q9Y6A1	Protein O-mannosyl-transferase 1	747	84881	8.69	12	Golgi apparatus;Endoplasmic reticulum membrane	Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A1;Muscular dystrophy-dystroglycanopathy congenital with mental retardation B1;Muscular dystrophy-dystroglycanopathy limb-girdle C1	Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:12369018, PubMed:14699049, PubMed:28512129). Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129).	NA	Belongs to the glycosyltransferase 39 family.	Protein modification; protein glycosylation.;Other types of O-glycan biosynthesis;Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2;O-linked glycosylation;Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	PE1	9
+NX_Q9Y6A2	Cholesterol 24-hydroxylase	500	56821	9.15	1	Microsome membrane;Endoplasmic reticulum membrane;Postsynapse;Presynapse;Dendrite	NA	P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697, PubMed:25017465, PubMed:18621681). By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning (By similarity). Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis (PubMed:12077124, PubMed:14640697, PubMed:28190002). Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain (PubMed:25017465). May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole (PubMed:20667828).	NA	Belongs to the cytochrome P450 family.	Steroid metabolism; cholesterol degradation.;Lipid metabolism; C21-steroid hormone metabolism.;Primary bile acid biosynthesis;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Endogenous sterols	PE1	14
+NX_Q9Y6A4	Cilia- and flagella-associated protein 20	193	22774	9.78	0	Centriole;Cilium;Cilium basal body;Nucleoplasm;Nucleus	NA	Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia (PubMed:24414207). Required for axonemal microtubules polyglutamylation (PubMed:24414207).	NA	Belongs to the CFAP20 family.	NA	PE1	16
+NX_Q9Y6A5	Transforming acidic coiled-coil-containing protein 3	838	90360	4.97	0	Cytoplasm;Centriolar satellite;Spindle pole;Centrosome;Cytoplasmic vesicle;Cytosol;Spindle	NA	Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).	NA	Belongs to the TACC family.	RNA transport;NOTCH3 Activation and Transmission of Signal to the Nucleus;Negative regulation of NOTCH4 signaling	PE1	4
+NX_Q9Y6A9	Signal peptidase complex subunit 1	169	18298	8.95	2	Microsome membrane;Golgi apparatus;Endoplasmic reticulum membrane;Cell membrane;Endoplasmic reticulum;Cytoplasmic vesicle	NA	Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.;(Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV) (PubMed:24009510, PubMed:27383988, PubMed:29593046). Plays a key role in the post-translational processing of flaviviral structural proteins prM, E, and NS1 (PubMed:27383988, PubMed:29593046). In HCV, it is involved in virion assembly where it promotes the interaction between HCV virus proteins NS2 and E2 (PubMed:24009510).	NA	Belongs to the SPCS1 family.	Protein export;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);SRP-dependent cotranslational protein targeting to membrane;Synthesis, secretion, and deacylation of Ghrelin	PE1	3
+NX_Q9Y6B2	EP300-interacting inhibitor of differentiation 1	187	20876	3.89	0	Nucleoplasm;Cytoplasm;Nucleus	NA	Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.	Ubiquitinated in U2OS osteosarcoma cells and is rapidly degraded by proteasome as cells exit the cell cycle exit.	NA	NA	PE1	15
+NX_Q9Y6B6	GTP-binding protein SAR1b	198	22410	5.76	0	Golgi stack membrane;Endoplasmic reticulum membrane	Chylomicron retention disease	Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.	NA	Belongs to the small GTPase superfamily. SAR1 family.	Protein processing in endoplasmic reticulum;Legionellosis;MHC class II antigen presentation;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;Cargo concentration in the ER;Chylomicron assembly	PE1	5
+NX_Q9Y6B7	AP-4 complex subunit beta-1	739	83260	5.59	0	Cytoplasmic vesicle;trans-Golgi network membrane	Spastic paraplegia 47, autosomal recessive	Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).	NA	Belongs to the adaptor complexes large subunit family.	Lysosome;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis	PE1	1
+NX_Q9Y6C2	EMILIN-1	1016	106695	5.1	0	Extracellular matrix	NA	May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.	NA	NA	Molecules associated with elastic fibres	PE1	2
+NX_Q9Y6C5	Protein patched homolog 2	1203	130544	6	12	Membrane	Medulloblastoma;Basal cell carcinoma;Basal cell nevus syndrome	Plays a role in the control of cellular growth (PubMed:18285427). May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).	NA	Belongs to the patched family.	Hedgehog signaling pathway;Pathways in cancer;Basal cell carcinoma;Class B/2 (Secretin family receptors)	PE1	1
+NX_Q9Y6C7	Putative uncharacterized protein encoded by LINC00312	94	11024	10.19	0	NA	NA	NA	NA	NA	NA	PE5	3
+NX_Q9Y6C9	Mitochondrial carrier homolog 2	303	33331	8.25	3	Mitochondrion inner membrane;Mitochondrion	NA	The substrate transported is not yet known. Induces mitochondrial depolarization.	NA	Belongs to the mitochondrial carrier (TC 2.A.29) family.	NA	PE1	11
+NX_Q9Y6D0	Selenoprotein K	94	10645	10.86	1	Nucleoplasm;Cytosol;Endoplasmic reticulum membrane;Cell membrane	NA	Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (PubMed:20692228). Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588).	Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity (By similarity).	Belongs to the selenoprotein K family.	NA	PE1	3
+NX_Q9Y6D5	Brefeldin A-inhibited guanine nucleotide-exchange protein 2	1785	202038	5.93	0	trans-Golgi network;Cytoplasm;Golgi apparatus;Membrane;Dendrite;Endosome;Centrosome;Synapse;Cytoplasmic vesicle;Perinuclear region;Cytoskeleton	Periventricular nodular heterotopia 2	Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.	In vitro phosphorylated by PKA reducing its GEF activity and dephosphorylated by phosphatase PP1.	NA	Association of TriC/CCT with target proteins during biosynthesis	PE1	20
+NX_Q9Y6D6	Brefeldin A-inhibited guanine nucleotide-exchange protein 1	1849	208767	5.58	0	Golgi apparatus;Cytoplasm;Nucleus matrix;trans-Golgi network membrane;Nucleolus;Nucleoplasm;Cytosol;Perinuclear region;Nucleus	NA	Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined.	Phosphorylated. In vitro phosphorylated by PKA reducing its GEF activity and dephosphorylated by phosphatase PP1.	NA	NA	PE1	8
+NX_Q9Y6D9	Mitotic spindle assembly checkpoint protein MAD1	718	83067	5.72	0	Nucleus membrane;Nucleoplasm;Spindle pole;Nucleus envelope;Centrosome;Nucleus;Spindle;Kinetochore	NA	Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.	Phosphorylated; by BUB1. Become hyperphosphorylated in late S through M phases or after mitotic spindle damage.	Belongs to the MAD1 family.	Cell cycle;Progesterone-mediated oocyte maturation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	PE1	7
+NX_Q9Y6E0	Serine/threonine-protein kinase 24	443	49308	5.49	0	Cytoplasm;Nucleolus;Membrane;Cytosol;Nucleus	NA	Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.	Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear translocation of the truncated form (MST3/N) and the induction of apoptosis.;Is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese, magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc-dependent autophosphorylation is on both serine and threonine residues.	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	Apoptotic cleavage of cellular proteins;Apoptotic execution phase	PE1	13
+NX_Q9Y6E2	Basic leucine zipper and W2 domain-containing protein 2	419	48162	6.26	0	Cytosol;Cell membrane;Cytoskeleton	NA	May be involved in neuronal differentiation.	NA	Belongs to the BZW family.	NA	PE1	7
+NX_Q9Y6E7	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial	314	35188	9.04	0	Mitochondrion matrix	NA	Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Does not seem to deacetylate PC (PubMed:23438705). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310). Down-regulates insulin secretion.	NA	Belongs to the sirtuin family. Class II subfamily.	Transcriptional activation of mitochondrial biogenesis	PE1	12
+NX_Q9Y6F1	Protein mono-ADP-ribosyltransferase PARP3	533	60089	6.34	0	Centriole;Chromosome;Nucleoplasm;Centrosome;Nucleus	NA	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:16924674, PubMed:20064938, PubMed:21211721, PubMed:21270334, PubMed:25043379, PubMed:24598253). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (PubMed:20064938, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ (PubMed:24598253). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6 (PubMed:16924674, PubMed:24598253). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (PubMed:16924674). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (PubMed:29361132, PubMed:29520010). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity).	Auto-mono-ADP-ribosylated.	NA	Base excision repair	PE1	3
+NX_Q9Y6F6	Protein MRVI1	904	97957	5.48	1	Sarcoplasmic reticulum;Membrane;Cytosol;Perinuclear region;Nucleus	NA	Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.	Phosphorylated by PRKG1/cGKI-beta; Ser-386 showed constitutive phosphorylation in platelets whereas Ser-676 is only phosphorylated in presence of cGMP and nitric oxide (NO); Ser-689 is phosphorylated in resting platelets but increases in presence of cGMP and NO. PRKG1 inhibitor prevents phosphorylation of Ser-676 and Ser-689 in response to NO and cGMP.	NA	Vascular smooth muscle contraction;cGMP effects	PE1	11
+NX_Q9Y6F7	Testis-specific chromodomain protein Y 2	541	60524	9.14	0	Nucleus	NA	May have histone acetyltransferase activity.	NA	NA	NA	PE1	Y
+NX_Q9Y6F8	Testis-specific chromodomain protein Y 1	540	60473	9.21	0	Nucleus	NA	Has histone acetyltransferase activity, with a preference for histone H4.	NA	NA	NA	PE1	Y
+NX_Q9Y6F9	Protein Wnt-6	365	39721	9.22	0	Extracellular matrix	NA	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.	Belongs to the Wnt family.	Wnt signaling pathway;Hedgehog signaling pathway;Melanogenesis;HTLV-I infection;Pathways in cancer;Basal cell carcinoma;WNT ligand biogenesis and trafficking;Class B/2 (Secretin family receptors)	PE1	2
+NX_Q9Y6G1	Transmembrane protein 14A	99	10712	10.55	3	Mitochondrion membrane;Endoplasmic reticulum;Nucleoplasm;Endoplasmic reticulum membrane	NA	Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.	NA	Belongs to the TMEM14 family.	NA	PE1	6
+NX_Q9Y6G3	39S ribosomal protein L42, mitochondrial	142	16661	8.58	0	Mitochondrion;Cell membrane	NA	NA	NA	Belongs to the mitochondrion-specific ribosomal protein mL42 family.	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation termination	PE1	12
+NX_Q9Y6G5	COMM domain-containing protein 10	202	22966	6.09	0	Nucleoplasm;Cytoplasm;Nucleus	NA	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).	NA	NA	Neddylation	PE1	5
+NX_Q9Y6G9	Cytoplasmic dynein 1 light intermediate chain 1	523	56579	6.01	0	Cytoplasm;Spindle pole;Centrosome;Cytosol;Kinetochore	NA	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.	Phosphorylated during mitosis but not in interphase.	Belongs to the dynein light intermediate chain family.	Phagosome;Vasopressin-regulated water reabsorption;Salmonella infection;Separation of Sister Chromatids;MHC class II antigen presentation;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;COPI-independent Golgi-to-ER retrograde traffic;COPI-mediated anterograde transport;Neutrophil degranulation;HSP90 chaperone cycle for steroid hormone receptors (SHR)	PE1	3
+NX_Q9Y6H1	Coiled-coil-helix-coiled-coil-helix domain-containing protein 2	151	15513	9.43	0	Mitochondrion intermembrane space;Mitochondrion;Nucleus	Parkinson disease 22	Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788).	NA	NA	Mitochondrial protein import	PE1	7
+NX_Q9Y6H3	Mitochondrial inner membrane protease ATP23 homolog	246	28081	8.3	0	Cytoplasmic vesicle;Cytosol;Cell junction;Cell membrane	NA	NA	NA	Belongs to the peptidase M76 family.	NA	PE1	12
+NX_Q9Y6H5	Synphilin-1	919	100409	5.96	0	Nucleoplasm;Cytosol;Cytoplasm	Parkinson disease	Modulates SNCA monoubiquitination by SIAH1.;Inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH.;Inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins.	Is subject to limited ubiquitination that does not lead to proteasomal degradation.;Ubiquitinated; mediated by SIAH1, SIAH2 or RNF19A and leading to its subsequent proteasomal degradation. In the absence of proteasomal degradation, ubiquitinated SNCAIP accumulates in cytoplasmic inclusion bodies.	NA	Parkinson's disease;Amyloid fiber formation	PE1	5
+NX_Q9Y6H6	Potassium voltage-gated channel subfamily E member 3	103	11710	8.82	1	Cytoplasm;Cell membrane;Perikaryon;Membrane raft;Dendrite	NA	Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.	NA	Belongs to the potassium channel KCNE family.	Protein digestion and absorption;Phase 3 - rapid repolarisation;Phase 2 - plateau phase	PE1	11
+NX_Q9Y6H8	Gap junction alpha-3 protein	435	47410	6.15	4	Gap junction;Cell membrane	Cataract 14, multiple types	Structural component of lens fiber gap junctions (PubMed:30044662). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells (By similarity). They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:30044662).	NA	Belongs to the connexin family. Alpha-type (group II) subfamily.	Gap junction assembly	PE1	13
+NX_Q9Y6I0	Endogenous retrovirus group K member 6 Pro protein	156	16972	5.86	0	NA	NA	Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.	NA	PE3	7
+NX_Q9Y6I3	Epsin-1	576	60293	4.72	0	Cytoplasm;Cell membrane;Clathrin-coated pit;Cytosol;Nucleus	NA	Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.	Ubiquitinated.;Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.;EPN1 is phosphorylated by MAPK3	Belongs to the epsin family.	Endocytosis;EGFR downregulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	19
+NX_Q9Y6I4	Ubiquitin carboxyl-terminal hydrolase 3	520	58897	8.54	0	Nucleoplasm;Nucleus	NA	Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.	NA	Belongs to the peptidase C19 family. USP3 subfamily.	Ub-specific processing proteases	PE1	15
+NX_Q9Y6I7	WD repeat and SOCS box-containing protein 1	421	47432	7.63	0	Cytoplasm;Mitochondrion;Nucleus	NA	Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.	NA	NA	Protein modification; protein ubiquitination.;Antigen processing: Ubiquitination &amp; Proteasome degradation;Neddylation	PE1	17
+NX_Q9Y6I8	Peroxisomal membrane protein 4	212	24264	10.07	2	Peroxisome;Peroxisome membrane;Nucleolus	NA	NA	NA	Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisome;Class I peroxisomal membrane protein import	PE1	20
+NX_Q9Y6I9	Testis-expressed protein 264	313	34189	4.79	1	Cytosol;Autophagosome;Endoplasmic reticulum membrane;Nucleolus	NA	Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537).	NA	NA	Platelet degranulation	PE1	3
+NX_Q9Y6J0	Calcineurin-binding protein cabin-1	2220	246352	5.7	0	Nucleoplasm;Cytosol;Nucleus	NA	May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.	Upon genotoxic stress, ubiquitination by the DCX(DDB2) E3 ubiquitin-protein ligase complex targets CABIN1 for proteasomal degradation, leading to the release of p53/TP53.;Activated through PKC-mediated hyperphosphorylation. Phosphorylation by the DNA damage kinases ATM and CHK2 enhances ubiquitination.	NA	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	PE1	22
+NX_Q9Y6J3	SMAD5 antisense gene protein 1	95	10312	9.43	0	NA	NA	NA	NA	NA	NA	PE2	5
+NX_Q9Y6J6	Potassium voltage-gated channel subfamily E member 2	123	14472	5.57	1	Cell membrane	Atrial fibrillation, familial, 4;Long QT syndrome 6	Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505).	NA	Belongs to the potassium channel KCNE family.	Gastric acid secretion;Phase 3 - rapid repolarisation;Phase 2 - plateau phase	PE1	21
+NX_Q9Y6J8	Serine/threonine/tyrosine-interacting-like protein 1	313	35818	5.73	0	Mitochondrion matrix;Nucleus speckle	NA	Catalytically inactive phosphatase (PubMed:20180778, PubMed:23163895). By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules (PubMed:20180778, PubMed:23163895). Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity (PubMed:24709986). By inhibiting PTPMT1, positively regulates intrinsic apoptosis (PubMed:21262771). May play a role in the formation of neurites during neuronal development (PubMed:29250526).	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.	NA	PE1	7
+NX_Q9Y6J9	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	622	67814	9.14	0	Nucleoplasm;Nucleus	NA	Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity).	NA	Belongs to the TAF6 family.	Basal transcription factors;Herpes simplex infection;HATs acetylate histones	PE1	11
+NX_Q9Y6K0	Choline/ethanolaminephosphotransferase 1	416	46554	8.55	8	Endoplasmic reticulum membrane;Nucleus membrane	NA	Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.	NA	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.;Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.;Glycerophospholipid metabolism;Ether lipid metabolism;Metabolic pathways;Synthesis of PC;Synthesis of PE	PE1	1
+NX_Q9Y6K1	DNA (cytosine-5)-methyltransferase 3A	912	101858	6.19	0	Cytoplasm;Nucleoplasm;Nucleus	Tatton-Brown-Rahman syndrome	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.	Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription.	Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Cysteine and methionine metabolism;Metabolic pathways;RMTs methylate histone arginines;PRC2 methylates histones and DNA;DNA methylation;SUMOylation of DNA methylation proteins	PE1	2
+NX_Q9Y6K5	2'-5'-oligoadenylate synthase 3	1087	121170	8.73	0	Cytoplasm;Cell membrane;Nucleoplasm;Cytosol;Nucleus	NA	Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).	NA	Belongs to the 2-5A synthase family.	Hepatitis C;Measles;Influenza A;Herpes simplex infection;Interferon gamma signaling;Interferon alpha/beta signaling;OAS antiviral response	PE1	12
+NX_Q9Y6K8	Adenylate kinase isoenzyme 5	562	63333	4.96	0	Cytoplasm;Cytosol;Centriolar satellite	NA	Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.	NA	Belongs to the adenylate kinase family.	Purine metabolism;Metabolic pathways;Interconversion of nucleotide di- and triphosphates	PE1	1
+NX_Q9Y6K9	NF-kappa-B essential modulator	419	48198	5.56	0	Cytoplasm;Cytosol;Nucleus	Recurrent isolated invasive pneumococcal disease 2;Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis and lymphedema;Immunodeficiency, NEMO-related, without anhidrotic ectodermal dysplasia;Incontinentia pigmenti;Ectodermal dysplasia and immunodeficiency 1;Immunodeficiency 33	Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.	(Microbial infection) Polyubiquitinated on Lys-309 and Lys-321 via 'Lys-27'-linked ubiquitin by Shigella flexneri E3 ubiquitin-protein ligase ipah9.8, leading to its degradation by the proteasome.;Neddylated by TRIM40, resulting in stabilization of NFKBIA and down-regulation of NF-kappa-B activity.;Sumoylated on Lys-277 and Lys-309 with SUMO1; the modification results in phosphorylation of Ser-85 by ATM leading to a replacement of the sumoylation by mono-ubiquitination on these residues.;Phosphorylation at Ser-68 attenuates aminoterminal homodimerization.;(Microbial infection) Cleaved by hepatitis A virus (HAV) protease 3C allowing the virus to disrupt the host innate immune signaling.;Polyubiquitinated on Lys-285 through 'Lys-63'; the ubiquitination is mediated by NOD2 and RIPK2 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Polyubiquitinated on Lys-399 through 'Lys-63'; the ubiquitination is mediated by BCL10, MALT1 and TRAF6 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Monoubiquitinated on Lys-277 and Lys-309; promotes nuclear export. Polyubiquitinated through 'Lys-27' by TRIM23; involved in antiviral innate and inflammatory responses. Linear polyubiquitinated on Lys-111, Lys-143, Lys-226, Lys-246, Lys-264, Lys-277, Lys-285, Lys-292, Lys-302, Lys-309 and Lys-326; the head-to-tail polyubiquitination is mediated by the LUBAC complex and plays a key role in NF-kappa-B activation. Deubiquitinated by USP10 in a TANK-dependent and -independent manner, leading to the negative regulation of NF-kappa-B signaling upon DNA damage (PubMed:25861989).;IKBKG is phosphorylated by MAPK3	NA	MAPK signaling pathway;Chemokine signaling pathway;Apoptosis;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;T cell receptor signaling pathway;B cell receptor signaling pathway;Adipocytokine signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Chagas disease (American trypanosomiasis);Toxoplasmosis;Hepatitis C;HTLV-I infection;Herpes simplex infection;Pathways in cancer;Pancreatic cancer;Prostate cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Primary immunodeficiency;Activation of NF-kappaB in B cells;ER-Phagosome pathway;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Downstream TCR signaling;NOD1/2 Signaling Pathway;activated TAK1 mediates p38 MAPK activation;RIP-mediated NFkB activation via ZBP1;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;TRAF6 mediated NF-kB activation;IKK complex recruitment mediated by RIP1;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;IRAK1 recruits IKK complex;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Ub-specific processing proteases;Ovarian tumor domain proteases;TICAM1, RIP1-mediated IKK complex recruitment;Interleukin-1 signaling;SUMOylation of immune response proteins	PE1	X
+NX_Q9Y6L6	Solute carrier organic anion transporter family member 1B1	691	76449	8.85	12	Basolateral cell membrane	Hyperbilirubinemia, Rotor type	Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.	NA	Belongs to the organo anion transporter (TC 2.A.60) family.	Bile secretion;Transport of organic anions;Recycling of bile acids and salts;Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR);Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	PE1	12
+NX_Q9Y6L7	Tolloid-like protein 2	1015	113557	5.6	0	Secreted	NA	Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.	NA	NA	Degradation of the extracellular matrix;Collagen biosynthesis and modifying enzymes;Crosslinking of collagen fibrils;Anchoring fibril formation	PE1	10
+NX_Q9Y6M0	Testisin	314	34884	7.56	0	Cytosol;Cell membrane	NA	Could regulate proteolytic events associated with testicular germ cell maturation.	NA	Belongs to the peptidase S1 family.	Post-translational modification: synthesis of GPI-anchored proteins	PE1	16
+NX_Q9Y6M1	Insulin-like growth factor 2 mRNA-binding protein 2	599	66121	8.48	0	Cytoplasm;Cytosol;Nucleus	NA	RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.	NA	Belongs to the RRM IMP/VICKZ family.	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	PE1	3
+NX_Q9Y6M4	Casein kinase I isoform gamma-3	447	51389	9.29	0	Cytoplasm	NA	Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).	Autophosphorylated.	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.	Hedgehog signaling pathway	PE1	5
+NX_Q9Y6M5	Zinc transporter 1	507	55300	6.02	6	Cytoplasmic vesicle;Cell membrane	NA	May be involved in zinc transport out of the cell.	NA	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.	Mineral absorption;Zinc efflux and compartmentalization by the SLC30 family	PE1	1
+NX_Q9Y6M7	Sodium bicarbonate cotransporter 3	1214	136044	6.26	11	Cell membrane;Basolateral cell membrane;Focal adhesion;Cytosol;Stereocilium;Apical cell membrane	NA	Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.	NA	Belongs to the anion exchanger (TC 2.A.31) family.	Bicarbonate transporters	PE1	3
+NX_Q9Y6M9	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	179	21831	8.57	0	Mitochondrion inner membrane;Mitochondrion	Mitochondrial complex I deficiency, nuclear type 24	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	NA	Belongs to the complex I LYR family.	Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease;Respiratory electron transport;Complex I biogenesis	PE1	8
+NX_Q9Y6N1	Cytochrome c oxidase assembly protein COX11, mitochondrial	276	31430	9.22	1	Mitochondrion inner membrane	NA	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.	NA	Belongs to the COX11/CtaG family.	Oxidative phosphorylation;Metabolic pathways;Respiratory electron transport;TP53 Regulates Metabolic Genes	PE1	17
+NX_Q9Y6N3	Calcium-activated chloride channel regulator family member 3	262	29971	8.42	0	Secreted	NA	NA	N-glycosylated.	Belongs to the CLCR family.	Stimuli-sensing channels	PE1	1
+NX_Q9Y6N5	Sulfide:quinone oxidoreductase, mitochondrial	450	49961	9.18	0	Mitochondrion	NA	Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).	NA	Belongs to the SQRD family.	Sulfide oxidation to sulfate	PE1	15
+NX_Q9Y6N6	Laminin subunit gamma-3	1575	171227	6.14	0	Basement membrane	Cortical malformations occipital	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	NA	NA	Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer;Non-integrin membrane-ECM interactions;Laminin interactions;MET activates PTK2 signaling	PE1	9
+NX_Q9Y6N7	Roundabout homolog 1	1651	180930	5.7	1	Endoplasmic reticulum-Golgi intermediate compartment membrane;Axon;Cell membrane	NA	Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity).	Ubiquitinated. May be deubiquitinated by USP33.	Belongs to the immunoglobulin superfamily. ROBO family.	Axon guidance;Netrin-1 signaling;Signaling by ROBO receptors;Activation of RAC1;Inactivation of CDC42 and RAC1;Role of ABL in ROBO-SLIT signaling;Regulation of commissural axon pathfinding by SLIT and ROBO;Regulation of expression of SLITs and ROBOs;SLIT2:ROBO1 increases RHOA activity;Regulation of cortical dendrite branching	PE1	3
+NX_Q9Y6N8	Cadherin-10	788	88451	4.83	1	Cell membrane	NA	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	NA	NA	Adherens junctions interactions	PE1	5
+NX_Q9Y6N9	Harmonin	552	62211	5.36	0	Cytosol;Microvillus;Cytoskeleton	Deafness, autosomal recessive, 18A;Usher syndrome 1C	Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (PubMed:24725409, PubMed:26812018).	NA	NA	NA	PE1	11
+NX_Q9Y6P5	Sestrin-1	492	56557	5.68	0	Nucleoplasm;Nucleolus;Cytoplasm;Nucleus	NA	Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity).	NA	Belongs to the sestrin family.	p53 signaling pathway;TP53 Regulates Metabolic Genes	PE1	6
+NX_Q9Y6Q1	Calpain-6	641	74576	6.62	0	Cytoplasmic vesicle;Spindle;Perinuclear region	NA	Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).	NA	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	X
+NX_Q9Y6Q2	Stonin-1	735	83141	5.82	0	Membrane;Cytoplasm	NA	May be involved in the endocytic machinery.	NA	Belongs to the Stoned B family.	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis	PE1	2
+NX_Q9Y6Q3	Zinc finger protein 37 homolog	630	71209	9.26	0	Nucleoplasm;Nucleus;Cytoplasmic vesicle	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	Generic Transcription Pathway	PE1	9
+NX_Q9Y6Q5	AP-1 complex subunit mu-2	423	48108	8.23	0	Golgi apparatus;Cytoplasmic vesicle;Clathrin-coated vesicle membrane	NA	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.	Belongs to the adaptor complexes medium subunit family.	Lysosome;MHC class II antigen presentation;Golgi Associated Vesicle Biogenesis;Lysosome Vesicle Biogenesis;Nef mediated downregulation of MHC class I complex cell surface expression	PE1	19
+NX_Q9Y6Q6	Tumor necrosis factor receptor superfamily member 11A	616	66034	5.21	1	Cytosol;Cell membrane	Familial expansile osteolysis;Osteopetrosis, autosomal recessive 7;Paget disease of bone 2, early-onset	Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.	NA	NA	Cytokine-cytokine receptor interaction;Osteoclast differentiation;Rheumatoid arthritis;TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	PE1	18
+NX_Q9Y6Q9	Nuclear receptor coactivator 3	1424	155293	7.16	0	Nucleoplasm;Cytosol;Cytoplasm;Nucleus	NA	Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.	Methylated by CARM1.;Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.;Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.;NCOA3 is phosphorylated by IKBKB (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);NCOA3 is phosphorylated by PRKCZ (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255);NCOA3 is phosphorylated by CHUK (Phosphoserine,Phosphothreonine,Phosphotyrosine:PTM-0253,PTM-0254,PTM-0255)	Belongs to the SRC/p160 nuclear receptor coactivator family.	MAPK6/MAPK4 signaling;PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Estrogen-dependent gene expression	PE1	20
+NX_Q9Y6R0	Numb-like protein	609	64891	9.1	0	Cytoplasm	NA	Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.	NA	NA	Notch signaling pathway	PE1	19
+NX_Q9Y6R1	Electrogenic sodium bicarbonate cotransporter 1	1079	121461	6.35	12	Basolateral cell membrane	Renal tubular acidosis, proximal, with ocular abnormalities and mental retardation	May have a higher activity than isoform 1.;Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.	N-glycosylation is not necessary for the transporter basic functions.;Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase; phosphorylation seems to inhibit SLC4A4 activity.	Belongs to the anion exchanger (TC 2.A.31) family.	Proximal tubule bicarbonate reclamation;Pancreatic secretion;Bile secretion;Bicarbonate transporters;Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	PE1	4
+NX_Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	1608	181685	5.94	0	Cytosol;Perinuclear region	NA	Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.	NA	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MAPK signaling pathway;GnRH signaling pathway	PE1	6
+NX_Q9Y6R6	Zinc finger protein 780B	833	96807	9.17	0	Nucleus	NA	May be involved in transcriptional regulation.	NA	Belongs to the krueppel C2H2-type zinc-finger protein family.	NA	PE1	19
+NX_Q9Y6R7	IgGFc-binding protein	5405	572017	5.14	0	Golgi apparatus;Secreted;Cytoskeleton;Cell membrane	NA	May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.	NA	NA	NA	PE1	19
+NX_Q9Y6R9	Coiled-coil domain-containing protein 61	512	57368	10.27	0	Nucleoplasm	NA	NA	NA	NA	NA	PE1	19
+NX_Q9Y6S9	Ribosomal protein S6 kinase-like 1	549	60036	7.06	0	Nucleoplasm	NA	NA	NA	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.	NA	PE1	14
+NX_Q9Y6T7	Diacylglycerol kinase beta	804	90595	8.11	0	Cytoplasm	NA	Exhibits high phosphorylation activity for long-chain diacylglycerols.	NA	Belongs to the eukaryotic diacylglycerol kinase family.	Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Effects of PIP2 hydrolysis	PE1	7
+NX_Q9Y6U3	Adseverin	715	80489	5.5	0	Podosome;Cell membrane;Cytoskeleton	NA	Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).	NA	Belongs to the villin/gelsolin family.	Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton	PE1	7
+NX_Q9Y6U7	RING finger protein 215	377	41101	8.98	2	Membrane;Nucleolus;Cytoskeleton	NA	NA	NA	NA	NA	PE2	22
+NX_Q9Y6V0	Protein piccolo	5142	560699	6.07	0	Presynaptic active zone;Nucleus speckle;Cell membrane	Pontocerebellar hypoplasia 3	Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity).	NA	NA	NA	PE1	7
+NX_Q9Y6V7	Probable ATP-dependent RNA helicase DDX49	483	54226	9.21	0	Mitochondrion;Nucleolus	NA	NA	NA	Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol	PE1	19
+NX_Q9Y6W3	Calpain-7	813	92652	7.55	0	Nucleus	NA	Calcium-regulated non-lysosomal thiol-protease.	NA	Belongs to the peptidase C2 family.	Degradation of the extracellular matrix	PE1	3
+NX_Q9Y6W5	Wiskott-Aldrich syndrome protein family member 2	498	54284	5.38	0	Cytoplasm;Cell membrane;Lamellipodium;Cytosol;Cytoskeleton	NA	Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.	NA	Belongs to the SCAR/WAVE family.	Adherens junction;Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Shigellosis;Salmonella infection;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;VEGFA-VEGFR2 Pathway	PE1	1
+NX_Q9Y6W6	Dual specificity protein phosphatase 10	482	52642	7.87	0	Golgi apparatus;Cytoplasm;Nucleoplasm;Cytosol;Nucleus	NA	Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.	NA	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.	MAPK signaling pathway;RAF-independent MAPK1/3 activation;Negative regulation of MAPK pathway	PE1	1
+NX_Q9Y6W8	Inducible T-cell costimulator	199	22625	9.01	1	Secreted;Cell membrane;Cytoskeleton	Immunodeficiency, common variable, 1	Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).	N-glycosylated.	NA	Cell adhesion molecules (CAMs);T cell receptor signaling pathway;Intestinal immune network for IgA production;Primary immunodeficiency;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Costimulation by the CD28 family;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PE1	2
+NX_Q9Y6X0	SET-binding protein	1596	175008	9.76	0	Nucleoplasm;Cytosol;Nucleus	Leukemia, juvenile myelomonocytic;Myelodysplastic syndrome;Leukemia, chronic myeloid, atypical;Schinzel-Giedion midface retraction syndrome;Leukemia, acute myelogenous;Mental retardation, autosomal dominant 29	NA	NA	NA	NA	PE1	18
+NX_Q9Y6X1	Stress-associated endoplasmic reticulum protein 1	66	7374	11.01	1	Membrane;Endoplasmic reticulum;Endoplasmic reticulum membrane;Cell membrane	NA	Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).	NA	Belongs to the RAMP4 family.	XBP1(S) activates chaperone genes;Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PE1	3
+NX_Q9Y6X2	E3 SUMO-protein ligase PIAS3	628	68017	7.81	0	Nucleoplasm;Cytoplasm;Nucleus speckle;Nucleus	NA	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).	Sumoylated.	Belongs to the PIAS family.	Protein modification; protein sumoylation.;Ubiquitin mediated proteolysis;Jak-STAT signaling pathway;Hepatitis C;Pathways in cancer;Small cell lung cancer;Formation of Incision Complex in GG-NER;SUMOylation of DNA replication proteins;SUMOylation of transcription factors;SUMOylation of intracellular receptors;SUMOylation of transcription cofactors;SUMOylation of immune response proteins	PE1	1
+NX_Q9Y6X3	MAU2 chromatid cohesion factor homolog	613	69082	6.84	0	Nucleoplasm;Nucleus;Chromosome	NA	Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:28167679, PubMed:22628566). Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16802858, PubMed:16682347).	NA	Belongs to the SCC4/mau-2 family.	Cohesin Loading onto Chromatin	PE1	19
+NX_Q9Y6X4	Soluble lamin-associated protein of 75 kDa	670	74955	4.52	0	Nucleus inner membrane;Cytosol;Nucleus envelope;Nucleus membrane	NA	NA	NA	Belongs to the FAM169 family.	NA	PE1	5
+NX_Q9Y6X5	Bis(5'-adenosyl)-triphosphatase ENPP4	453	51641	5.71	1	Cell membrane	NA	Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.	NA	Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.	Neutrophil degranulation	PE1	6
+NX_Q9Y6X6	Unconventional myosin-XVI	1858	206129	6.37	0	Cytoplasm;Cytoplasmic vesicle	NA	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).	Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.	In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.;In the C-terminal section; belongs to the NYAP family.	NA	PE1	13
+NX_Q9Y6X8	Zinc fingers and homeoboxes protein 2	837	92307	6.42	0	Nucleoplasm;Nucleus	NA	Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).	NA	Belongs to the ZHX family.	NA	PE1	8
+NX_Q9Y6X9	ATPase MORC2	1032	117823	8.6	0	Nucleus matrix;Chromosome;Nucleoplasm;Cytosol;Nucleus	Charcot-Marie-Tooth disease 2Z	Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AFX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20225202, PubMed:20110259). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864).	Phosphorylated by PAK1 at Ser-739 upon DNA damage. Phosphorylation is required for ATPase activity and recruitment to damaged chromatin.	NA	Fatty acyl-CoA biosynthesis	PE1	22
+NX_Q9Y6Y0	Influenza virus NS1A-binding protein	642	71729	5.33	0	Nucleoplasm;Cytosol;Cytoplasm;Cytoskeleton	NA	Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811).;(Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.	NA	NA	Influenza A	PE1	1